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Sample records for function assessment compared

  1. Complementary approaches to the assessment of personality disorder. The Personality Assessment Schedule and Adult Personality Functioning Assessment compared.

    Science.gov (United States)

    Hill, J; Fudge, H; Harrington, R; Pickles, A; Rutter, M

    2000-05-01

    Current concepts and measures of personality disorder are in many respects unsatisfactory. To establish agreement between two contrasting measures of personality disorder, and to compare subject-informant agreement on each. To examine the extent to which trait abnormality can be separated from interpersonal and social role dysfunction. Fifty-six subjects and their closest informants were interviewed and rated independently. Personality functioning was assessed using a modified Personality Assessment Schedule (M-PAS), and the Adult Personality Functioning Assessment (APFA). Subject-informant agreement on the M-PAS was moderately good, and agreement between the M-PAS and the APFA, across and within subjects and informants, was comparable to that for the M-PAS. This was equally the case when M-PAS trait plus impairment scores and trait abnormality scores were used. The M-PAS and the APFA are probably assessing similar constructs. Trait abnormalities occur predominantly in an interpersonal context and could be assessed within that context.

  2. Total hip arthroplasty outcomes assessment using functional and radiographic scores to compare canine systems.

    Science.gov (United States)

    Iwata, D; Broun, H C; Black, A P; Preston, C A; Anderson, G I

    2008-01-01

    A retrospective multi-centre study was carried out in order to compare outcomes between cemented and uncemented total hip arthoplasties (THA). A quantitative orthopaedic outcome assessment scoring system was devised in order to relate functional outcome to a numerical score, to allow comparison between treatments and amongst centres. The system combined a radiographic score and a clinical score. Lower scores reflect better outcomes than higher scores. Consecutive cases of THA were included from two specialist practices between July 2002 and December 2005. The study included 46 THA patients (22 uncemented THA followed for 8.3 +/- 4.7M and 24 cemented THA for 26.0 +/- 15.7M) with a mean age of 4.4 +/- 3.3 years at surgery. Multi-variable linear and logistical regression analyses were performed with adjustments for age at surgery, surgeon, follow-up time, uni- versus bilateral disease, gender and body weight. The differences between treatment groups in terms of functional scores or total scores were not significant (p > 0.05). Radiographic scores were different between treatment groups. However, these scores were usually assessed within two months of surgery and proved unreliable predictors of functional outcome (p > 0.05). The findings reflect relatively short-term follow-up, especially for the uncemented group, and do not include clinician-derived measures, such as goniometry and thigh circumference. Longer-term follow-up for the radiographic assessments is essential. A prospective study including the clinician-derived outcomes needs to be performed in order to validate the outcome instrument in its modified form.

  3. Comparing impedance cardiography and echocardiography in the assessment of reduced left ventricular systolic function

    DEFF Research Database (Denmark)

    Kaszuba, Elzbieta; Scheel, Sergej; Odeberg, Håkan

    2013-01-01

    An early and accurate diagnosis of chronic heart failure is a big challenge for a general practitioner. Assessment of left ventricular function is essential for the diagnosis of heart failure and the prognosis. A gold standard for identifying left ventricular function is echocardiography...

  4. 99mTc-DMSA assessment of unilateral renal function: comparative study of two methods

    International Nuclear Information System (INIS)

    Llamas, J.M.; Torres, M.; Mallol, J.; Latre, J.M.; Martinez Paredes, M.; Carreras, J.L.

    1987-01-01

    Results obtained with two different methods of assessing unilateral renal function by measuring the percentage of relative uptake following the administration of a tracing dose of Tc 99m -DMSA are compared in a sample of 40 patients with various conditions. As a reference test, I 131 -hippurate 1'-2' relative uptake, corrected by normalized background and attenuation, was employed. Tc 99m -DMSA relative uptake was determined at 24 hours using the following methods: 1) Percentage of accumulated counts over each renal area in relation to the total, for two minutes, corrected by normalized background and attenuation. 2) Percentage of accumulated counts over each renal area in relation to the total, obtained from the geometrical mean value of accumulated counts in AP and PA projections. A correlation analysis between the two methods, and between these and the reference test, were performed. Good correlations among them (r=0,98 between double-image DMS and Hippurate; p<0,001 in all cases) were found. (author)

  5. Functioning assessment vs. conventional medical assessment: a comparative study on health professionals’ clinical decision-making and the fit with patient’s own perspective of health

    NARCIS (Netherlands)

    Stallinga, Gonda; Roodbol, Petrie; Annema, Coby; Jansen, Gerard; Wynia, Klaske

    2013-01-01

    Aims and objectives. To compare a functioning assessment based on the International Classification of Functioning, Disability and Health (ICF) with a conventional medical assessment, in terms of their respective consequences for health professionals’ clinical decision-making and the fit with

  6. Functioning assessment vs. conventional medical assessment : a comparative study on health professionals' clinical decision-making and the fit with patient's own perspective of health

    NARCIS (Netherlands)

    Stallinga, Hillegonda A.; Roodbol, Petrie F.; Annema, Coby; Jansen, Gerard J.; Wynia, Klaske

    Aims and objectives. To compare a functioning assessment based on the International Classification of Functioning, Disability and Health (ICF) with a conventional medical assessment, in terms of their respective consequences for health professionals' clinical decision-making and the fit with

  7. Comparing the responsiveness of functional outcome assessment measures for trauma registries.

    Science.gov (United States)

    Williamson, Owen D; Gabbe, Belinda J; Sutherland, Ann M; Wolfe, Rory; Forbes, Andrew B; Cameron, Peter A

    2011-07-01

    Measuring long-term disability and functional outcomes after major trauma is not standardized across trauma registries. An ideal measure would be responsive to change but not have significant ceiling effects. The aim of this study was to compare the responsiveness of the Glasgow Outcome Scale (GOS), GOS-Extended (GOSE), Functional Independence Measure (FIM), and modified FIM in major trauma patients, with and without significant head injuries. Patients admitted to two adult Level I trauma centers in Victoria, Australia, who survived to discharge from hospital, were aged 15 years to 80 years with a blunt mechanism of injury, and had an estimated Injury Severity Score >15 on admission, were recruited for this prospective study. The instruments were administered at baseline (hospital discharge) and by telephone interview 6 months after injury. Measures of responsiveness, including effect sizes, were calculated. Bootstrapping techniques, and floor and ceiling effects, were used to compare the measures. Two hundred forty-three patients participated, of which 234 patients (96%) completed the study. The GOSE and GOS were the most responsive instruments in this major trauma population with effect sizes of 5.3 and 4.4, respectively. The GOSE had the lowest ceiling effect (17%). The GOSE was the instrument with greatest responsiveness and the lowest ceiling effect in a major trauma population with and without significant head injuries and is recommended for use by trauma registries for monitoring functional outcomes and benchmarking care. The results of this study do not support the use of the modified FIM for this purpose.

  8. Density Functional Theory versus the Hartree-Fock Method: Comparative Assessment

    International Nuclear Information System (INIS)

    Amusia, M.Ya.; Shaginyan, V.R.; Msezane, A.Z.

    2003-01-01

    We compare two different approaches to investigations of many-electron systems. The first is the Hartree-Fock (HF) method and the second is the Density Functional Theory (DFT). Overview of the main features and peculiar properties of the HF method are presented. A way to realize the HF method within the Kohn-Sham (KS) approach of the DFT is discussed. We show that this is impossible without including a specific correlation energy, which is defined by the difference between the sum of the kinetic and exchange energies of a system considered within KS and HF, respectively. It is the nonlocal exchange potential entering the HF equations that generates this correlation energy. We show that the total correlation energy of a finite electron system, which has to include this correlation energy, cannot be obtained from considerations of uniform electron systems. The single-particle excitation spectrum of many-electron systems is related to the eigenvalues of the corresponding KS equations. We demonstrate that this spectrum does not coincide in general with the eigenvalues of KS or HF equations

  9. Density Functional Theory versus the Hartree-Fock Method: Comparative Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Amusia, M.Ya.; Shaginyan, V.R. [The Hebrew University, Jerusalem (Israel); Msezane, A.Z. [Clark Atlanta Univ., Atlanta, GA (United States). Center for Theoretical Studies of Physical Systems

    2003-12-01

    We compare two different approaches to investigations of many-electron systems. The first is the Hartree-Fock (HF) method and the second is the Density Functional Theory (DFT). Overview of the main features and peculiar properties of the HF method are presented. A way to realize the HF method within the Kohn-Sham (KS) approach of the DFT is discussed. We show that this is impossible without including a specific correlation energy, which is defined by the difference between the sum of the kinetic and exchange energies of a system considered within KS and HF, respectively. It is the nonlocal exchange potential entering the HF equations that generates this correlation energy. We show that the total correlation energy of a finite electron system, which has to include this correlation energy, cannot be obtained from considerations of uniform electron systems. The single-particle excitation spectrum of many-electron systems is related to the eigenvalues of the corresponding KS equations. We demonstrate that this spectrum does not coincide in general with the eigenvalues of KS or HF equations.

  10. Intra-operative Assessment of the Spinal Cord Function: Awakening Compared to Ankle Clonus Test

    International Nuclear Information System (INIS)

    Amin, Wafik A.; Tealab, Ayman I.; Ei-Gendy, Eslah H.; Esmat, Hesham A.

    2006-01-01

    The spinal cord is at high risk of injury during special procedures such as correction of scoliosis. Recovery from impairement is directly proportional to the time of removal of the instrumentations. For this, methods used to detect the neurologic injury should be continuous, fast, sensitive and specific. The present study was performed to evaluate the ankle clonus as a test for the integrity of the spinal cord function intraoperatively. Twenty eight scoliotic patients were included in the study. The ankle clonus was tested before, during and after the correction and fixation followed by the wake-up test to correlate the results of both rests. The haemodynamics changes at the time of the two tests were compared. It was found out that, the ankle clonus test correlated well with the wake-up test, with only two false positive results. No false negative results were recorded which was an important finding. The haemodynamic changes were better during the ankle clonus test than during the wake-up test. It was concluded that the ankle clonus test is reliable, safe, and faster than the wake-up test. It is recommended to use the test to evaluate the integrity of the spinal cord during the operations with potential risk to the cord. In case the result of the ankle clonus is positive, the wake-up test should be done before an attempt to release or remove the instrumentations. (author)

  11. Assessing Intellectual Functioning in Young Adolescents: How Do the WISC-IV and SB5 Compare?

    Science.gov (United States)

    Wilson, Kimberley; Gilmore, Linda

    2012-01-01

    The Wechsler Intelligence Scale for Children--Fourth Edition (WISC-IV) and the Stanford-Binet--Fifth Edition (SB5) are two of the most commonly used intelligence tests for children and adolescents. No comparative studies of the WISC-IV and SB5 have yet been published. In the current study the WISC-IV and SB5 were administered in counterbalanced…

  12. Assessment of left atrial volume and function: a comparative study between echocardiography, magnetic resonance imaging and multi slice computed tomography.

    Science.gov (United States)

    Kühl, J Tobias; Lønborg, Jacob; Fuchs, Andreas; Andersen, Mads J; Vejlstrup, Niels; Kelbæk, Henning; Engstrøm, Thomas; Møller, Jacob E; Kofoed, Klaus F

    2012-06-01

    Measurement of left atrial (LA) maximal volume (LA(max)) using two-dimensional transthoracic echocardiography (TTE) provides prognostic information in several cardiac diseases. However, the relationship between LA(max) and LA function is poorly understood and TTE is less well suited for measuring dynamic LA volume changes. Conversely, cardiac magnetic resonance imaging (CMR) and multi-slice computed tomography (MSCT) appears more appropriate for such measures. We sought to determine the relationship between LA size assessed with TTE and LA size and function assessed with CMR and MSCT. Fifty-four patients were examined 3 months post myocardial infarction with echocardiography, CMR and MSCT. Left atrial volumes and LA reservoir function were assessed by TTE. LA time-volume curves were determined and LA reservoir function (cyclic change and fractional change), passive emptying function (reservoir volume) and pump function (left atrial ejection fraction-LAEF) were derived using CMR and MSCT. Left atrial fractional change and left atrial ejection fraction (LAEF) determined with CMR and MSCT were unrelated to LA(max) enlargement by echocardiography (P = NS). There was an overall good agreement between CMR and MSCT, with a small to moderate bias in LA(max) (4.9 ± 10.4 ml), CC (3.1 ± 9.1 ml) and reservoir volume (3.4 ± 9.1 ml). TTE underestimates LA(max) with up to 32% compared with CMR and MSCT (P fractional change and LAEF is not significantly related to LA(max) measured by TTE. TTE systematically underestimated LA volumes, whereas there are good agreements between MSCT and CMR for volumetric and functional properties.

  13. Comparative Judgement for Assessment

    Science.gov (United States)

    Pollitt, Alastair

    2012-01-01

    Historically speaking, students were judged long before they were marked. The tradition of marking, or scoring, pieces of work students offer for assessment is little more than two centuries old, and was introduced mainly to cope with specific problems arising from the growth in the numbers graduating from universities as the industrial revolution…

  14. Radiology compared with xenon—133 scanning and bronchoscopic lobar sampling as methods for assessing regional lung function in patients with emphysema

    Science.gov (United States)

    Barter, C. E.; Hugh-Jones, P.; Laws, J. W.; Crosbie, W. A.

    1973-01-01

    Regional lung function was assessed by radiographic methods, by regional function studies using xenon-133 scans, and by lobar sampling with a mass spectrometer flow-meter at bronchoscopy in 12 patients who subsequently had bullae resected at operation. The information given by these three methods of regional assessment was subsequently compared with the findings at operation. When only one lobe was abnormal on the radiographs, these alone were adequate to locate the major site of the emphysema and the regional tests gave relatively little extra information. The xenon scan was sometimes helpful in assessing the state of the remaining lung, but this information could be deduced from the radiographs and overall lung function tests, especially the carbon monoxide transfer and mechanical measurements. Bronchoscopic sampling was helpful in determining whether the affected lobe was acting as a ventilated dead-space. When more than one lobe was affected the regional function tests supplemented the radiographs in defining the site of bullous change as well as locating dead space. Xenon scans, although widely employed for such preoperative assessments, added little to the topographical information obtained by careful radiology. The combination of radiology, lobar sampling, and overall function tests is recommended for assessing which emphysematous patients are likely to benefit from surgery. Images PMID:4685209

  15. Comparative Assessment of the Heart's Functioning by Using the Akabane Test and Classical Methods of Instrumental Examination

    Directory of Open Access Journals (Sweden)

    Valery Muzhikov

    2017-06-01

    Full Text Available Acupuncture physicians have studied the application of reflexotherapy to cardiology. However, no one has investigated the connection of ancient Chinese diagnostic methods with modern tools. A total of 102 patients (54 men and 48 women with heart pathology, namely, sick-sinus syndrome, Wolff–Parkinson–White syndrome, and atrioventricular blockade, were studied using the usual instrumental methods (transesophageal electrophysiological study of the heart, echocardiography, after which they underwent Akabane thermopuncture testing as in traditional Chinese medicine. The results of cardio examination from one side of the Akabane test with that from the other side were compared by means of a multiple stepwise regression analysis. We revealed the effects on the characteristic pattern of acupuncture channel lesions inherent in a definite heart pathology, i.e., the most vulnerable acupuncture channel (AC, of such factors as disturbances of the contractile, conductive, or automatic heart functions, and changes in the chambers' size or circulation volume. Сhanges in the indices of the left and the right branches of these channels usually reflect the opposing natures of the changes in these indicators, which should be considered in reflexotherapy. The main value of the Akabane test along with the use of mathematical analysis lies in early, quick, and inexpensive detection of the above-mentioned heart disturbances.

  16. Functional Assessment Inventory Manual.

    Science.gov (United States)

    Crewe, Nancy M.; Athelstan, Gary T.

    This manual, which provides extensive new instructions for administering the Functional Assessment Inventory (FAI), is intended to enable counselors to begin using the inventory without undergoing any special training. The first two sections deal with the need for functional assessment and issues in the development and use of the inventory. The…

  17. The comparability of English, French and Dutch scores on the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F: an assessment of differential item functioning in patients with systemic sclerosis.

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    Linda Kwakkenbos

    Full Text Available The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F is commonly used to assess fatigue in rheumatic diseases, and has shown to discriminate better across levels of the fatigue spectrum than other commonly used measures. The aim of this study was to assess the cross-language measurement equivalence of the English, French, and Dutch versions of the FACIT-F in systemic sclerosis (SSc patients.The FACIT-F was completed by 871 English-speaking Canadian, 238 French-speaking Canadian and 230 Dutch SSc patients. Confirmatory factor analysis was used to assess the factor structure in the three samples. The Multiple-Indicator Multiple-Cause (MIMIC model was utilized to assess differential item functioning (DIF, comparing English versus French and versus Dutch patient responses separately.A unidimensional factor model showed good fit in all samples. Comparing French versus English patients, statistically significant, but small-magnitude DIF was found for 3 of 13 items. French patients had 0.04 of a standard deviation (SD lower latent fatigue scores than English patients and there was an increase of only 0.03 SD after accounting for DIF. For the Dutch versus English comparison, 4 items showed small, but statistically significant, DIF. Dutch patients had 0.20 SD lower latent fatigue scores than English patients. After correcting for DIF, there was a reduction of 0.16 SD in this difference.There was statistically significant DIF in several items, but the overall effect on fatigue scores was minimal. English, French and Dutch versions of the FACIT-F can be reasonably treated as having equivalent scoring metrics.

  18. The Comparability of English, French and Dutch Scores on the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F): An Assessment of Differential Item Functioning in Patients with Systemic Sclerosis

    Science.gov (United States)

    Kwakkenbos, Linda; Willems, Linda M.; Baron, Murray; Hudson, Marie; Cella, David; van den Ende, Cornelia H. M.; Thombs, Brett D.

    2014-01-01

    Objective The Functional Assessment of Chronic Illness Therapy- Fatigue (FACIT-F) is commonly used to assess fatigue in rheumatic diseases, and has shown to discriminate better across levels of the fatigue spectrum than other commonly used measures. The aim of this study was to assess the cross-language measurement equivalence of the English, French, and Dutch versions of the FACIT-F in systemic sclerosis (SSc) patients. Methods The FACIT-F was completed by 871 English-speaking Canadian, 238 French-speaking Canadian and 230 Dutch SSc patients. Confirmatory factor analysis was used to assess the factor structure in the three samples. The Multiple-Indicator Multiple-Cause (MIMIC) model was utilized to assess differential item functioning (DIF), comparing English versus French and versus Dutch patient responses separately. Results A unidimensional factor model showed good fit in all samples. Comparing French versus English patients, statistically significant, but small-magnitude DIF was found for 3 of 13 items. French patients had 0.04 of a standard deviation (SD) lower latent fatigue scores than English patients and there was an increase of only 0.03 SD after accounting for DIF. For the Dutch versus English comparison, 4 items showed small, but statistically significant, DIF. Dutch patients had 0.20 SD lower latent fatigue scores than English patients. After correcting for DIF, there was a reduction of 0.16 SD in this difference. Conclusions There was statistically significant DIF in several items, but the overall effect on fatigue scores was minimal. English, French and Dutch versions of the FACIT-F can be reasonably treated as having equivalent scoring metrics. PMID:24638101

  19. Global seismic attenuation imaging using full-waveform inversion: a comparative assessment of different choices of misfit functionals

    Science.gov (United States)

    Karaoǧlu, Haydar; Romanowicz, Barbara

    2018-02-01

    We present the results of synthetic tests that aim at evaluating the relative performance of three different definitions of misfit functionals in the context of 3-D imaging of shear wave attenuation in the earth's upper mantle at the global scale, using long-period full-waveform data. The synthetic tests are conducted with simple hypothetical upper-mantle models that contain Qμ anomalies centred at different depths and locations, with or without additional seismic velocity anomalies. To build synthetic waveform data sets, we performed simulations of 50 events in the hypothetical (target) models, using the spectral element method, filtered in the period range 60-400 s. The selected events are chosen among 273 events used in the development of radially anisotropic model SEMUCB-WM1 and recorded at 495 stations worldwide. The synthetic Z-component waveforms correspond to paths and time intervals (fundamental mode and overtone Rayleigh waves) that exist in the real waveform data set. The inversions for shear attenuation structure are carried out using a Gauss-Newton optimization scheme in which the gradient and Hessian are computed using normal mode perturbation theory. The three different misfit functionals considered are based on time domain waveform (WF) and waveform envelope (E-WF) differences, as well as spectral amplitude ratios (SA), between observed and predicted waveforms. We evaluate the performance of the three misfit functional definitions in the presence of seismic noise and unresolved S-wave velocity heterogeneity and discuss the relative importance of physical dispersion effects due to 3-D Qμ structure. We observed that the performance of WF is poorer than the other two misfit functionals in recovering attenuation structure, unless anelastic dispersion effects are taken into account in the calculation of partial derivatives. WF also turns out to be more sensitive to seismic noise than E-WF and SA. Overall, SA performs best for attenuation imaging. Our

  20. Functional assessment of chronic illness therapy—the fatigue scale exhibits stronger associations with clinical parameters in chronic dialysis patients compared to other fatigue-assessing instruments

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    Chia-Ter Chao

    2016-03-01

    Full Text Available Background. Patients with end-stage renal disease (ESRD have a high symptom burden, among which fatigue is highly prevalent. Many fatigue-assessing instruments exist, but comparisons among instruments in this patient population have yet to be investigated. Methods. ESRD patients under chronic hemodialysis were prospectively enrolled and seven types of fatigue instruments were administered: Brief Fatigue Inventory (BFI, Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-F, Fatigue Severity Scale (FSS, Lee Fatigue Scale (LFS, Fatigue Questionnaire (FQ, Fatigue Symptom Inventory (FSI, and Short-Form 36-Vitality (SF36-V. Using these instruments, we investigated the correlation between fatigue severity and clinical/biochemical parameters, including demographic/comorbidity profile, dialysis-related complications, and frailty severity. We used regression analysis with serum albumin and frailty severity as the dependent variables to investigate the independent correlations. Results. A total of 46 ESRD patients were enrolled (average age of 67 ± 11.6 years, and 50% of them had type 2 diabetes mellitus. Results from the seven tested instruments showed high correlation with each other. We found that the fatigue severity by FACIT-F was significantly associated with age (p = 0.03, serum albumin (p = 0.003 and creatinine (p = 0.02 levels, while SF36-V scores were also significantly associated with age (p = 0.02 and serum creatinine levels (p = 0.04. However, the fatigue severity measured by the FSS, FSI, FQ, BFI, and LFS did not exhibit these associations. Moreover, regression analysis showed that only FACIT-F scores were independently associated with serum albumin levels and frailty severity in ESRD patients. Conclusion. Among the seven fatigue-assessing instruments, only the FACIT-F yielded results that demonstrated significant and independent associations with important outcome-related features in ESRD patients.

  1. Comparative assessment of 18F-fluorodeoxyglucose PET and 99mTc-tetrofosmin SPECT for the prediction of functional recovery in patients with reperfused acute myocardial infarction

    International Nuclear Information System (INIS)

    Shirasaki, Haruhisa; Nakano, Akira; Uzui, Hiroyasu; Ueda, Takanori; Lee, Jong-Dae; Yonekura, Yoshiharu; Okazawa, Hidehiko

    2006-01-01

    Purpose: Although preserved glucose metabolism is considered to be a marker of myocardial viability in the chronic stage, it has not been fully elucidated whether this is also true with regard to reperfused acute myocardial infarction (AMI). The aim of this study was to compare the diagnostic performance of 99m Tc-tetrofosmin SPECT and 18 F-fluorodeoxyglucose (FDG) PET for the prediction of functional recovery in reperfused AMI.Methods: The study population comprised 28 patients. Both tetrofosmin SPECT and FDG PET were performed in all 28 patients at ca. 2 weeks and in 23 at 6 months. The tetrofosmin and FDG findings in infarct-related segments were compared with the regional wall motion score assessed by left ventriculography over 6 months to determine the predictive value for functional recovery. Of 120 infarct-related segments, 83 had preserved flow (tetrofosmin uptake ≥50%) and 81 had preserved glucose metabolism (FDG uptake ≥40%). The sensitivity and specificity of tetrofosmin SPECT for the prediction of functional recovery tended to be superior to those of FDG PET (90.0% and 72.5% vs 85.0% and 67.5%, respectively). Thirteen segments with preserved flow and decreased glucose metabolism demonstrated marked recovery of contractile function from 2.5±1.0 to 1.4±1.4 (p<0.01), with restoration of glucose metabolism at 6 months. In contrast, 11 segments with decreased flow and preserved glucose metabolism demonstrated incomplete functional improvement from 3.0±0.8 to 2.2±1.2. In the subacute phase, preserved myocardial blood flow is more reliable than glucose metabolism in predicting functional recovery in reperfused myocardium. (orig.)

  2. Functional categories in comparative linguistics

    DEFF Research Database (Denmark)

    Rijkhoff, Jan

    , Roger M. 1979. Linguistic knowledge and cultural knowledge: some doubts and speculation. American Anthropologist 81-1, 14-36. Levinson, Stephen C. 1997. From outer to inner space: linguistic categories and non-linguistic thinking. In J. Nuyts and E. Pederson (eds.), Language and Conceptualization, 13......). Furthermore certain ‘ontological categories’ are language-specific (Malt 1995). For example, speakers of Kalam (New Guinea) do not classify the cassowary as a bird, because they believe it has a mythical kinship relation with humans (Bulmer 1967).       In this talk I will discuss the role of functional...

  3. Assessment of left atrial appendage function by transthoracic pulsed Doppler echocardiography: Comparing against transesophageal interrogation and predicting echocardiographic risk factors for stroke.

    Science.gov (United States)

    Wai, Shin Hnin; Kyu, Kyu; Galupo, Mary Joyce; Songco, Geronica G; Kong, William K F; Lee, Chi Hang; Yeo, Tiong Cheng; Poh, Kian Keong

    2017-10-01

    Transesophageal echocardiographic (TEE) findings of left atrial appendage (LAA) thrombus, spontaneous echo contrast (SEC), and LAA dysfunction are established risk factors of cardioembolic stroke. The semi-invasive nature of TEE limits its utility as a routine risk stratification tool. We aim to correlate TEE and transthoracic echocardiography (TTE) pulsed Doppler measurements of LAA flow velocities and use TTE measurements to predict TEE findings. We prospectively measured pulsed Doppler LAA flow velocities in 103 consecutive patients on TEE and TTE. There was a strong correlation between TEE and TTE LAA emptying velocity (LAA E) (r = .88, P < .001) and a moderate correlation between LAA filling velocities (r = .50, P < .001). TTE LAA E predicted the presence of thrombus or SEC independent of atrial fibrillation (AF). To predict the presence of thrombus or SEC, the optimal TTE LAA E cutoff was ≤30 cm/s in all patients (75% sensitive, 90% specific) and ≤31 cm/s in AF patients (80% sensitive, 79% specific). To predict LAA dysfunction (TEE E ≤ 20 cm/s), the optimal TTE LAA E cutoff was ≤27 cm/s (100% sensitive, 89% specific in all patients and 100% sensitive, 74% specific in AF patients). TTE assessment of LAA function is feasible and correlates well with the more invasive TEE method. It predicts the presence of thrombus, SEC, and LAA dysfunction on TEE. TTE LAA assessment has incremental value in thromboembolic risk stratification and should be utilized more frequently. © 2017, Wiley Periodicals, Inc.

  4. Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function

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    Sudha S. Shankar

    2018-06-01

    Full Text Available Standard practice to minimize variability in beta cell function (BCF measurement is to test in inpatient (IP settings. IP testing strains trial subjects, investigators, and budgets. Outpatient (OP testing may be a solution although there are few reports on OP BCF testing variability. We compared variability metrics between OP and IP from a standardized mixed meal tolerance test (MMTT and arginine stimulation test (AST in two separate type 2 diabetes (T2DM cohorts (OP, n = 20; IP n = 22 in test-retest design. MMTT variables included: insulin sensitivity (Si; beta cell responsivity (Φtot; and disposition index (DItot = Si* Φtot following 470 kCal meal. AST variables included: acute insulin response to arginine (AIRarg and during hyperglycemia (AIRargMAX. Results: Baseline characteristics were well-matched. Between and within subject variance for each parameter across cohorts, and intraclass correlation coefficients (ICC-a measure of reproducibility across parameters were generally comparable for OP to IP. Table summarizes the ICC results for each key parameter and cohort.Test/ParameterOutpatient (95% CIInpatient (95% CIMMTT: Si0.49(0,0.690.28(0,0.60MMTT: Φtot0.65(0.16,0.890.81(0.44,0.93MMTT: DI0.67(0,0.830.36(0,0.69AST: AIR Arg0.96(0.88,0.980.84(0.59,0.94AST: AIR Arg Max0.97(0.90,0.990.95(0.86,0.97AST: ISR0.93(0.77,0.970.93(0.82,0.96In conclusion, the variability (reproducibility of BCF measures from standardized MMTT and AST is comparable between OP and IP settings. These observations have significant implications for complexity and cost of metabolic studies.

  5. Structure/Function Analysis of Cotton-Based Peptide-Cellulose Conjugates: Spatiotemporal/Kinetic Assessment of Protease Aerogels Compared to Nanocrystalline and Paper Cellulose

    Directory of Open Access Journals (Sweden)

    J. Vincent Edwards

    2018-03-01

    Full Text Available Nanocellulose has high specific surface area, hydration properties, and ease of derivatization to prepare protease sensors. A Human Neutrophil Elastase sensor designed with a nanocellulose aerogel transducer surface derived from cotton is compared with cotton filter paper, and nanocrystalline cellulose versions of the sensor. X-ray crystallography was employed along with Michaelis–Menten enzyme kinetics, and circular dichroism to contrast the structure/function relations of the peptide-cellulose conjugate conformation to enzyme/substrate binding and turnover rates. The nanocellulosic aerogel was found to have a cellulose II structure. The spatiotemporal relation of crystallite surface to peptide-cellulose conformation is discussed in light of observed enzyme kinetics. A higher substrate binding affinity (Km of elastase was observed with the nanocellulose aerogel and nanocrystalline peptide-cellulose conjugates than with the solution-based elastase substrate. An increased Km observed for the nanocellulosic aerogel sensor yields a higher enzyme efficiency (kcat/Km, attributable to binding of the serine protease to the negatively charged cellulose surface. The effect of crystallite size and β-turn peptide conformation are related to the peptide-cellulose kinetics. Models demonstrating the orientation of cellulose to peptide O6-hydroxymethyl rotamers of the conjugates at the surface of the cellulose crystal suggest the relative accessibility of the peptide-cellulose conjugates for enzyme active site binding.

  6. Structure/Function Analysis of Cotton-Based Peptide-Cellulose Conjugates: Spatiotemporal/Kinetic Assessment of Protease Aerogels Compared to Nanocrystalline and Paper Cellulose

    Science.gov (United States)

    Edwards, J. Vincent; Fontenot, Krystal; Liebner, Falk; Pircher, Nicole Doyle nee; French, Alfred D.; Condon, Brian D.

    2018-01-01

    Nanocellulose has high specific surface area, hydration properties, and ease of derivatization to prepare protease sensors. A Human Neutrophil Elastase sensor designed with a nanocellulose aerogel transducer surface derived from cotton is compared with cotton filter paper, and nanocrystalline cellulose versions of the sensor. X-ray crystallography was employed along with Michaelis–Menten enzyme kinetics, and circular dichroism to contrast the structure/function relations of the peptide-cellulose conjugate conformation to enzyme/substrate binding and turnover rates. The nanocellulosic aerogel was found to have a cellulose II structure. The spatiotemporal relation of crystallite surface to peptide-cellulose conformation is discussed in light of observed enzyme kinetics. A higher substrate binding affinity (Km) of elastase was observed with the nanocellulose aerogel and nanocrystalline peptide-cellulose conjugates than with the solution-based elastase substrate. An increased Km observed for the nanocellulosic aerogel sensor yields a higher enzyme efficiency (kcat/Km), attributable to binding of the serine protease to the negatively charged cellulose surface. The effect of crystallite size and β-turn peptide conformation are related to the peptide-cellulose kinetics. Models demonstrating the orientation of cellulose to peptide O6-hydroxymethyl rotamers of the conjugates at the surface of the cellulose crystal suggest the relative accessibility of the peptide-cellulose conjugates for enzyme active site binding. PMID:29534033

  7. Assessment of right atrial function analysis

    International Nuclear Information System (INIS)

    Shohgase, Takashi; Miyamoto, Atsushi; Kanamori, Katsushi; Kobayashi, Takeshi; Yasuda, Hisakazu

    1988-01-01

    To assess the potential utility of right atrial function analysis in cardiac disease, reservoir function, pump function, and right atrial peak emptying rate (RAPER) were compared in 10 normal subjects, 32 patients with coronary artery disease, and 4 patients with primary pulmonary hypertension. Right atrial volume curves were obtained using cardiac radionuclide method with Kr-81m. In normal subjects, reservoir function index was 0.41+-0.05; pump function index was 0.25+-0.05. Both types of patients has decreased reservoir funcion and increased pump function. Pump function tended to decrease with an increase of right ventricular end-diastolic pressure. RAPER correlated well with right ventricular peak filling rate, probably reflecting right ventricular diastolic function. Analysis of right atrial function seemed to be of value in evaluating factors regulating right ventricular contraction and diastolic function, and cardiac output. (Namekawa, K)

  8. Environmental Comparative Risk Assessment: A Case Study

    International Nuclear Information System (INIS)

    Ali, M.M.

    2007-01-01

    Health and environmental impacts associated with energy production and industrial activities as well as food production and agricultural activities have had great concern in the last decades. Early activities emerged in late 80s of the last century through an Inter- Agency project (lAEA, UNDY, WHO, ... ) on the comparative risk assessment from energy systems and industrial complexes. A work-shop on Risk Assessment and Management in large industrial areas was held in Alexandria Egypt on 20-33 Det 1993, sponsored by IAEA. Several conferences, experts work groups and workshops were held there of Recent trends in determining risks are: 1. Use of probabilistic risk assessment approach to identify hazardous activities and accident scenario. 2. development of data base on failure probabilities and appropriate physical models. 3. Development of related directives and regulations and criteria Comparative risk assessment case study as a tool for comparing risk is emphasized Criteria of exposure to human and ecological risks are addressed

  9. Assessment of right ventricular longitudinal strain by 2D speckle tracking imaging compared with RV function and hemodynamics in pulmonary hypertension.

    Science.gov (United States)

    Li, Yidan; Wang, Yidan; Meng, Xiangli; Zhu, Weiwei; Lu, Xiuzhang

    2017-11-01

    The right ventricular longitudinal strain (RVLS) of pulmonary hypertension (PH) patients and its relationship with RV function parameters measured by echocardiography and hemodynamic parameters measured by right heart catheterization was investigated. According to the WHO functional class (FC), 66 PH patients were divided into FC I/II (group 1) and III/IV (group 2). RV function parameters were measured by echocardiographic examinations. Hemodynamic parameters were obtained by right heart catheterization. Patients in group 2 had higher systolic pulmonary artery pressure (sPAP; P good sensitivity and specificity. Evidence has shown that RVLS measurement can provide the much-needed and reliable information on RV function and hemodynamics. Therefore, this qualifies as a patient-friendly approach for the clinical management of PH patients.

  10. Assessing Functional Vision Using Microcomputers.

    Science.gov (United States)

    Spencer, Simon; Ross, Malcolm

    1989-01-01

    The paper describes a software system which uses microcomputers to aid in the assessment of functional vision in visually impaired students. The software also aims to be visually stimulating and to develop hand-eye coordination, visual memory, and cognitive abilities. (DB)

  11. Quick Assessment of Family Functioning.

    Science.gov (United States)

    Golden, Larry B.

    1988-01-01

    Describes five criteria (parental resources, chronicity communication between family members, parental authority, and rapport with professional helpers) of family functioning of an assessment model which can be used to determine which families could benefit from brief interventions by a school counselor. Provides results of 20 case studies with…

  12. China and India, 2025: A Comparative Assessment

    Science.gov (United States)

    2011-01-01

    in China, see Banister, Bloom, and Rosenberg (2010). 13 For a discussion of inequality in India, see Bardhan (2003). population trends in China and...WorkingPapers/2010/PGDA_WP_53.pdf 132 China and India, 2025: A Comparative Assessment Bardhan , Pranab, “Crouching Tiger, Lumbering Elephant: A China-India

  13. A comparative assessment of commonly employed staining ...

    African Journals Online (AJOL)

    Following an increase in the number of reports of Cryptosporidium infections and the problems encountered in detecting these organisms in faecal smears, a comparative assessment of a modification of the Sheather's flotation technique and other commonly employed staining procedures proved the modified Sheather's ...

  14. Comparative analysis of proliferation resistance assessment methodologies

    International Nuclear Information System (INIS)

    Takaki, Naoyuki; Kikuchi, Masahiro; Inoue, Naoko; Osabe, Takeshi

    2005-01-01

    Comparative analysis of the methodologies was performed based on the discussions in the international workshop on 'Assessment Methodology of Proliferation Resistance for Future Nuclear Energy Systems' held in Tokyo, on March 2005. Through the workshop and succeeding considerations, it is clarified that the proliferation resistance assessment methodologies are affected by the broader nuclear options being pursued and also by the political situations of the state. Even the definition of proliferation resistance, despite the commonality of fundamental issues, derives from perceived threat and implementation circumstances inherent to the larger programs. Deep recognitions of the 'difference' among communities would help us to make further essential and progressed discussion with harmonization. (author)

  15. Assessment of visual function based on IOL-Master comparing with traditional ultrasonic biometry for intraocular lens calculation in high myopia patients

    Directory of Open Access Journals (Sweden)

    Lu Zhang

    2013-10-01

    Full Text Available AIM: To evaluate the clinical feasibility of using a new optical coherence interferometry(IOL-Master, comparing with traditional ultrasonic biometry and manual keratometry in the accuracy and characteristics for intraocular lens calculation of high myopia.METHODS: The measurement of axial length was performed in 60 eyes(30 eyes for each groupwith senile cataract of high myopia(≥-6.00Dusing IOL-Master and ultrasonic biometry. The measurement of corneal power(Kwas also performed in the patient using IOL-Master and manual keratometry preoperatively. Phacoemulsification and foldable lens implantation were done on the patients. IOL power calculation was carried out according to the SRK/T formula on the basis of the group-related data. Best corrected visual acuity, refraction, contrast sensitivity and wave front aberration root mean square(RMSwere re-tested after 3 months postoperatively.RESULTS: Significant difference between the two methods in axial length measurement which was 29.81±1.53mm by ultrasound and 29.63±1.81mm by IOL-Master(P=0.001. And in corneal power measurement which was 43.22±1.67K by manual keratometry and 44.27±1.39K by IOL-Master(P=0.006. There was a significant difference between the two groups(P=0.001. 63.0% vs 31.2% had a mean absolute refractive error(MAREwithin ±0.50 diopter for the IOL-Master and A-scan groups, respectively(χ2=3.1, Pth order aberration, 4th order spherical aberration and total high order aberration in the IOL-Master group were lower than those in the A-scan group at 6mm pupil diameter 3 months later. CONCLUSION: IOL-Master is a non-contact, accurate, safe and reliable tool for calculating IOL power and it is more accurate on the design of the IOL in the cataract surgery on the high myopia patients.

  16. Comparative risk assessment of total energy systems

    International Nuclear Information System (INIS)

    Soerensen, B.

    1982-01-01

    The paper discusses a methodology for total impact assessment of energy systems, ideally evaluating all the impacts that a given energy system has on the society in which it is imbedded or into which its introduction is being considered. Impacts from the entire energy conversion chain ('fuel cycle' if the system is fuel-based), including energy storage, transport and transmission, as well as the institutions formed in order to manage the system, should be compared on the basis of the energy service provided. A number of impacts are considered, broadly classified as impacts on satisfaction of biological needs, on health, on environment, on social relations and on the structure of society. Further considerations include impacts related to cost and resilience, and, last but not least, impacts on global relations. The paper discusses a number of published energy studies in the light of the comparative impact assessment methodology outlined above. (author)

  17. Comparative Assessment Of Natural Gas Accident Risks

    International Nuclear Information System (INIS)

    Burgherr, P.; Hirschberg, S.

    2005-01-01

    The study utilizes a hierarchical approach including (1) comparative analyses of different energy chains, (2) specific evaluations for the natural gas chain, and (3) a detailed overview of the German situation, based on an extensive data set provided by Deutsche Vereinigung des Gas- und Wasserfaches (DVGW). According to SVGW-expertise DVGW-data can be regarded as fully representative for Swiss conditions due to very similar technologies, management, regulations and safety culture, but has a substantially stronger statistical basis because the German gas grid is about 30 times larger compared to Switzerland. Specifically, the following tasks were carried out by PSI to accomplish the objectives of this project: (1) Consolidation of existing ENSAD data, (2) identification and evaluation of additional sources, (3) comparative assessment of accident risks, and (4) detailed evaluations of specific issues and technical aspects for severe and smaller accidents in the natural gas chain that are relevant under Swiss conditions. (author)

  18. Comparative Assessment of Energy Supply Options

    International Nuclear Information System (INIS)

    Rogner, H.-H.; Vladu, I. F.

    2000-01-01

    The complexity facing today's energy planners and decision-makers, particularly in electricity sector, has increased. They must take into account many elements in selecting technologies and strategies that will impact near term energy development and applications in their countries. While costs remain a key factor, tradeoffs between the demands of environmental protection and economic development will have to be made. This fact, together with the needs of many countries to define their energy and electricity programmes in a sustainable manner, has resulted in a growing interest in the application of improved data, tools and techniques for comparative assessment of different electricity generation options, particularly from an environmental and human health viewpoint. Although global emissions of greenhouse gases and other pollutants, e.g. SO 2 , NO x and particulate, must be reduced, the reality today is that these emissions are increasing and are expected to continue increasing. In examining the air pollutants, as well as water effluents and solid waste generated by electricity production, it is necessary to assess the full energy chain from fuel extraction to waste disposal, including the production of construction and auxiliary materials. The paper describes this concept and illustrates its implementation for assessing and comparing electricity generation costs, emissions, wastes and other environmental burdens from different energy sources. (author)

  19. Risk indices in comparative risk assessment studies

    International Nuclear Information System (INIS)

    Hubert, P.

    1984-01-01

    More than a decade ago the development of comparative risk assessment studies aroused overwhelming interest. There was no doubt that data on the health and safety aspects of energy systems would greatly benefit, or even end, the debate on nuclear energy. Although such attempts are still strongly supported, the rose-coloured expectations of the early days have faded. The high uncertainties, and the contradictory aspect, of the first results might explain this evolution. The loose connection between the range of computed risk indices and the questions on which the debate was focused is another reason for this decline in interest. Important research work is being carried out aiming at reducing the different kinds of uncertainties. Rather than the uncertainties, the paper considers the meaning of available risk indices and proposes more significant indices with respect to the goals of risk assessment. First, the indices which are of frequent use in comparative studies are listed. The stress is put on a French comparative study from which most examples are drawn. Secondly, the increase in magnitude of the indices and the decrease in the attributability of the risk to a given system is shown to be a consequence of the trend towards more comprehensive analyses. Thirdly, the ambiguity of such indices as the collective occupational risk is underlined, and a possible solution is suggested. Whenever risk assessments are related to pragmatic decision making problems it is possible to find satisfactory risk indices. The development of cost-effectiveness analyses and the proposals for quantitative safety goals clearly demonstrate this point. In the field of comparison of social impacts some proposals are made, but there remain some gaps still to be filled. (author)

  20. Comparative studies of groundwater vulnerability assessment

    Science.gov (United States)

    Maria, Rizka

    2018-02-01

    Pollution of groundwater is a primary issue because aquifers are susceptible to contamination from land use and anthropogenic impacts. Groundwater susceptibility is intrinsic and specific. Intrinsic vulnerability refers to an aquifer that is susceptible to pollution and to the geological and hydrogeological features. Vulnerability assessment is an essential step in assessing groundwater contamination. This approach provides a visual analysis for helping planners and decision makers to achieve the sustainable management of water resources. Comparative studies are applying different methodologies to result in the basic evaluation of the groundwater vulnerability. Based on the comparison of methods, there are several advantages and disadvantages. SI can be overlaid on DRASTIC and Pesticide DRASTIC to extract the divergence in sensitivity. DRASTIC identifies low susceptibility and underestimates the pollution risk while Pesticide DRASTIC and SI represents better risk and is recommended for the future. SINTACS method generates very high vulnerability zones with surface waters and aquifer interactions. GOD method could be adequate for vulnerability mapping in karstified carbonate aquifers at small-moderate scales, and EPIK method can be used for large scale. GOD method is suitable for designing large area such as land management while DRASTIC has good accuracy and more real use in geoenvironmental detailed studies.

  1. Assessment of left atrial volume and function

    DEFF Research Database (Denmark)

    Kühl, J Tobias; Lønborg, Jacob; Fuchs, Andreas

    2012-01-01

    dynamic LA volume changes. Conversely, cardiac magnetic resonance imaging (CMR) and multi-slice computed tomography (MSCT) appears more appropriate for such measures. We sought to determine the relationship between LA size assessed with TTE and LA size and function assessed with CMR and MSCT. Fifty......-four patients were examined 3 months post myocardial infarction with echocardiography, CMR and MSCT. Left atrial volumes and LA reservoir function were assessed by TTE. LA time-volume curves were determined and LA reservoir function (cyclic change and fractional change), passive emptying function (reservoir...... between CMR and MSCT, with a small to moderate bias in LA(max) (4.9 ± 10.4 ml), CC (3.1 ± 9.1 ml) and reservoir volume (3.4 ± 9.1 ml). TTE underestimates LA(max) with up to 32% compared with CMR and MSCT (P ...

  2. Assessment of the right ventricular function in patients with chronic obstructive pulmonary disease and cor pulmonale using cardiac 64-slice spiral CT comparing with 1.7 T MRI

    International Nuclear Information System (INIS)

    Gao Yan; Li Kuncheng; Du Xiangying; Liang Lei; Cao Lizhen; Li Yan; Zhao Shen; Guo Ying

    2009-01-01

    Objective: To assess the right ventricular function in patients with moderate to severe chronic obstructive pulmonary disease (COPD) and eor pulmonale using cardiac 64 MSCT comparing with MRI. Methods: Forty-six patients with COPD determined by pulmonary function test (PFT) were prospectively studied. According to the Global Initiative for COPD classification, the COPD patients were divided into three groups depending on the severity of the disease: mild COPD (16 cases), moderate COPD (16 cases) and severe COPD (14 cases). Twenty age-matched subjects were included as the controls. The RV function was assessed by 64-MSCT and 1.5 T cardiac MRI in all four groups. Pearson correlation analysis was used to evaluate the relationship between the right ventricular ejection fraction (RVEF), myocardial mass (MM) and the PFT results in COPD patients. AP value of less than 0.05 was considered statistically significant. End-diastolic volume (EDV), end-systolic volume (ESV), RVEF and MM on MSCT were compared with that on MRI using Pearson correlation analysis. Bland-Airman plot was used to evaluate the correlation between MSCT and MRI. Results: The RVEF was (51.6 ± 5.6)% in mild COPD, (49.8 ± 6.0)% in moderate COPD, (39.4 ± 7.2)% in severe COPD, and (53 ± 5.9)% in controls, respectively. The MM was (44.5 ± 5.4) g in mild COPD, (49.6 ± 5.0) g in moderate COPD, (57.1 ± 3.4) g in severe COPD, and (40.8 ± 3.9) g in controls, respectively. The EDV was (139.9 ± 25.0), (130.2 ± 21.2), (107.6 ± 18.4) and (149.2 ± 27.9) ml, the SV was (72.1 ± 16.1), (64.3 ± 11.0), (42.5 ± 16.5) and (77.0 ± 11.7) ml in four groups, respectively. The values of RVEF and RVEDV were significantly lower in severe COPD than that in mild COPD, moderate COPD and controls (F RVEF =143, F RVEDV =38.07, P RVEF = 1.03, F EDV =3.22, F EFV =0.44, F SV =2.77, P>0.05). The MM of the RV was significantly different between controls and the other three groups (F=66.34, P<0.01). All parameters of the RV

  3. Comparative proteomic assessment of matrisome enrichment methodologies

    Science.gov (United States)

    Krasny, Lukas; Paul, Angela; Wai, Patty; Howard, Beatrice A.; Natrajan, Rachael C.; Huang, Paul H.

    2016-01-01

    The matrisome is a complex and heterogeneous collection of extracellular matrix (ECM) and ECM-associated proteins that play important roles in tissue development and homeostasis. While several strategies for matrisome enrichment have been developed, it is currently unknown how the performance of these different methodologies compares in the proteomic identification of matrisome components across multiple tissue types. In the present study, we perform a comparative proteomic assessment of two widely used decellularisation protocols and two extraction methods to characterise the matrisome in four murine organs (heart, mammary gland, lung and liver). We undertook a systematic evaluation of the performance of the individual methods on protein yield, matrisome enrichment capability and the ability to isolate core matrisome and matrisome-associated components. Our data find that sodium dodecyl sulphate (SDS) decellularisation leads to the highest matrisome enrichment efficiency, while the extraction protocol that comprises chemical and trypsin digestion of the ECM fraction consistently identifies the highest number of matrisomal proteins across all types of tissue examined. Matrisome enrichment had a clear benefit over non-enriched tissue for the comprehensive identification of matrisomal components in murine liver and heart. Strikingly, we find that all four matrisome enrichment methods led to significant losses in the soluble matrisome-associated proteins across all organs. Our findings highlight the multiple factors (including tissue type, matrisome class of interest and desired enrichment purity) that influence the choice of enrichment methodology, and we anticipate that these data will serve as a useful guide for the design of future proteomic studies of the matrisome. PMID:27589945

  4. Comparative assessment of amphibious hearing in pinnipeds.

    Science.gov (United States)

    Reichmuth, Colleen; Holt, Marla M; Mulsow, Jason; Sills, Jillian M; Southall, Brandon L

    2013-06-01

    Auditory sensitivity in pinnipeds is influenced by the need to balance efficient sound detection in two vastly different physical environments. Previous comparisons between aerial and underwater hearing capabilities have considered media-dependent differences relative to auditory anatomy, acoustic communication, ecology, and amphibious life history. New data for several species, including recently published audiograms and previously unreported measurements obtained in quiet conditions, necessitate a re-evaluation of amphibious hearing in pinnipeds. Several findings related to underwater hearing are consistent with earlier assessments, including an expanded frequency range of best hearing in true seals that spans at least six octaves. The most notable new results indicate markedly better aerial sensitivity in two seals (Phoca vitulina and Mirounga angustirostris) and one sea lion (Zalophus californianus), likely attributable to improved ambient noise control in test enclosures. An updated comparative analysis alters conventional views and demonstrates that these amphibious pinnipeds have not necessarily sacrificed aerial hearing capabilities in favor of enhanced underwater sound reception. Despite possessing underwater hearing that is nearly as sensitive as fully aquatic cetaceans and sirenians, many seals and sea lions have retained acute aerial hearing capabilities rivaling those of terrestrial carnivores.

  5. UPPER LIMB FUNCTIONAL ASSESSMENT USING HAPTIC INTERFACE

    Directory of Open Access Journals (Sweden)

    Aleš Bardorfer

    2004-12-01

    Full Text Available A new method for the assessment of the upper limb (UL functional state, using a haptic interface is presented. A haptic interface is used as a measuring device, capable of providing objective, repeatable and quantitative data of the UL motion. A patient is presented with a virtual environment, both graphically via a computer screen and haptically via the Phantom Premium 1.5 haptic interface. The setup allows the patient to explore and feel the virtual environment with three of his/her senses; sight, hearing, and most important, touch. Specially designed virtual environments are used to assess the patient’s UL movement capabilities. The tests range from tracking tasks – to assess the accuracy of movement – tracking tasks with added disturbances in a form of random forces – to assess the patient’s control abilities, a labyrinth test – to assess both speed and accuracy, to the last test for measuring the maximal force capacity of the UL.A new method for the assessment of the upper limb (UL functional state, using a haptic interface is presented. A haptic interface is used as a measuring device, capable of providing objective, repeatable and quantitative data of the UL motion. A patient is presented with a virtual environment, both graphically via a computer screen and haptically via the Phantom Premium 1.5 haptic interface. The setup allows the patient to explore and feel the virtual environment with three of his/her senses; sight, hearing, and most important, touch. Specially designed virtual environments are used to assess the patient’s UL movement capabilities. The tests range from tracking tasks–to assess the accuracy of movement-tracking tasks with added disturbances in a form of random forces-to assess the patient’s control abilities, a labyrinth test-to assess both speed and accuracy, to the last test for measuring the maximal force capacity of the UL.A comprehensive study, using the developed measurement setup within the

  6. Energy modeling and comparative assessment beyond the market

    International Nuclear Information System (INIS)

    Rogner, H.-H.; Langlois, L.; McDonald, A.; Jalal, I.

    2004-01-01

    Market participants engage in constant comparative assessment of prices, available supplies, consumer options. Such implicit comparative assessment is a sine qua non for decision making in, and the smooth function of, competitive markets, but it is not always sufficient for policy makers who make decisions based on priorities other than or in addition to market prices. Supplementary mechanisms are needed to make explicit, to expose for consideration and to incorporate into their decision making processes, broader factors that are not necessarily reflected directly in the market price of a good or service. These would include, for example, employment, environment, national security or trade considerations. They would include long-term considerations, e.g., global warming or greatly diminished future supplies of oil and gas. This paper explores different applications of comparative assessment beyond the market, reviews different approaches for accomplishing such evaluations, and presents some tools available for conducting various types of extra-market comparative assessment, including those currently in use by Member States of the IAEA.(author)

  7. Assessing elders using the functional health pattern assessment model.

    Science.gov (United States)

    Beyea, S; Matzo, M

    1989-01-01

    The impact of older Americans on the health care system requires we increase our students' awareness of their unique needs. The authors discuss strategies to develop skills using Gordon's Functional Health Patterns Assessment for assessing older clients.

  8. Assessment of adrenal function in liver diseases

    Directory of Open Access Journals (Sweden)

    Sandeep Kharb

    2013-01-01

    Full Text Available Background: In recent times, there are reports of adrenal dysfunction in whole spectrum of liver disease. Adrenal insufficiency (AI has been shown to correlate with progression of liver disease. Hence this study was conducted to assess adrenal function in subjects with acute liver disease (ALD, chronic liver disease (CLD and post liver transplantation (LT. Material and Methods: This study included 25 healthy controls, 25 patients of ALD, 20 subjects of CLD with Child-Pugh stage A (CLD-1 and 30 with Child-Pugh stage B or C (CLD-2, and 10 subjects with LT. All subjects were assessed clinically, biochemically and for adrenal functions. Results: AI was present in 9 (34.6% patients with ALD, 20 (40% patients with CLD and 4 (40% in subjects with LT. AI was more common in CLD-2 (18 patients - 60% than CLD-1 (2 patients - 10%. All patients with chronic liver disease had significantly lower basal cortisol (8.8±4.8, P=0.01, stimulated cortisol (18.2±6.3, P <0.00001 and incremental cortisol (9.4±4.6, P <0.00001 as compared to controls. There was increase in percentage of subjects with adrenal dysfunction with progression of liver disease as assessed by Child-Pugh staging. AI was predicted by lower levels of serum protein, serum albumin, total cholesterol and HDL cholesterol and higher levels of serum bilirubin and INR. Adrenal functions showed recovery following liver transplantation. Conclusions: AI forms important part of spectrum of acute and chronic liver disease. Deterioration of synthetic functions of liver disease predicts presence of AI, and these patients should be evaluated for adrenal dysfunction periodically.

  9. Cardiorespiratory functional assessment after pediatric heart transplantation.

    Science.gov (United States)

    Pastore, E; Turchetta, A; Attias, L; Calzolari, A; Giordano, U; Squitieri, C; Parisi, F

    2001-12-01

    Limited data are available on the exercise capacity of young heart transplant recipients. The aim of this study was therefore to assess cardiorespiratory responses to exercise in this group of patients. Fourteen consecutive heart transplant recipients (six girls and eight boys, age-range 5-15 yr) and 14 healthy matched controls underwent a Bruce treadmill test to determine: duration of test; resting and maximum heart rates; maximum systolic blood pressure; peak oxygen consumption (VO2 peak); and cardiac output. Duration of test and heart rate increase were then compared with: time since transplantation, rejections per year, and immunosuppressive drugs received. The recipients also underwent the following lung function tests: forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). When compared with healthy controls, transplant recipients had tachycardia at rest (126 +/- 3.7 beats/min; p physical activity, possibly owing to over-protective parents and teachers and to a lack of suitable supervised facilities. The authors stress the importance of a cardiorespiratory functional evaluation for assessment of health status and to encourage recipients, if possible, to undertake regular physical activity.

  10. A Framework for Comparative Assessments of Energy Efficiency Policy Measures

    Energy Technology Data Exchange (ETDEWEB)

    Blum, Helcio; Atkinson, Barbara; Lekov, Alex

    2011-05-24

    When policy makers propose new policies, there is a need to assess the costs and benefits of the proposed policy measures, to compare them to existing and alternative policies, and to rank them according to their effectiveness. In the case of equipment energy efficiency regulations, comparing the effects of a range of alternative policy measures requires evaluating their effects on consumers’ budgets, on national energy consumption and economics, and on the environment. Such an approach should be able to represent in a single framework the particularities of each policy measure and provide comparable results. This report presents an integrated methodological framework to assess prospectively the energy, economic, and environmental impacts of energy efficiency policy measures. The framework builds on the premise that the comparative assessment of energy efficiency policy measures should (a) rely on a common set of primary data and parameters, (b) follow a single functional approach to estimate the energy, economic, and emissions savings resulting from each assessed measure, and (c) present results through a set of comparable indicators. This framework elaborates on models that the U.S. Department of Energy (DOE) has used in support of its rulemakings on mandatory energy efficiency standards. In addition to a rigorous analysis of the impacts of mandatory standards, DOE compares the projected results of alternative policy measures to those projected to be achieved by the standards. The framework extends such an approach to provide a broad, generic methodology, with no geographic or sectoral limitations, that is useful for evaluating any type of equipment energy efficiency market intervention. The report concludes with a demonstration of how to use the framework to compare the impacts estimated for twelve policy measures focusing on increasing the energy efficiency of gas furnaces in the United States.

  11. Comparative analysis of selected hydromorphological assessment methods

    Czech Academy of Sciences Publication Activity Database

    Šípek, Václav; Matoušková, M.; Dvořák, M.

    2010-01-01

    Roč. 169, 1-4 (2010), s. 309-319 ISSN 0167-6369 Institutional support: RVO:67985874 Keywords : Hydromorphology * Ecohydromorphological river habitat assessment: EcoRivHab * Rapid Bioassessment Protocol * LAWA Field and Overview Survey * Libechovka River * Bilina River * Czech Republic Subject RIV: DA - Hydrology ; Limnology Impact factor: 1.436, year: 2010

  12. Comparative assessment of university chemistry undergraduate ...

    African Journals Online (AJOL)

    A comparative analysis of the structure of undergraduate chemistry curricula of universities in the southwest of Nigeria with a view to establishing the relative proportion of the different areas of chemistry each curriculum accommodates. It is a qualitative research, involving content analysis with a partial quantitative analysis ...

  13. Framework for Multi-Pathway Cumulative Exposure for Comparative Assessments

    DEFF Research Database (Denmark)

    McKone, Tom; Fantke, Peter

    2016-01-01

    in comparative risk assessment, life-cycle assessment (LCA), and chemical alternatives assessment (CAA), multimedia fate and exposure models synthesize information about partitioning, reaction, and intermedia-transport properties of chemicals in a representative (local to regional) or generic (continental...

  14. Comparative Testing for Corporate Impact Assessment Tools

    DEFF Research Database (Denmark)

    Farsang, Andrea; Reisch, Lucia A.

    of our study are: poverty, water and sanitation, education, food and agriculture, climate change, and human rights in three industries, namely: footwear, coffee, and paper and pulp. The paper develops a protocol for the selection and quantification of indicators that can be used in selecting...... the appropriate tools for measuring impacts in the selected sectors on SDGs. Background: In the Global Value Project, a long list of indicators was compiled covering the main thematic areas and challenges of sustainability. In a second step, this long list was reduced using predefined criteria as well as other...... criteria, such as the feasibility and scalability of different tools. As a result, a protocol was developed to help compare the different tools that measure corporate impact and to interpret the results in relation to the SDGs. The protocol was pre-tested with a limited number of tools in two case studies...

  15. Comparative risk assessment in the energy industry

    International Nuclear Information System (INIS)

    Hamilton, L.D.

    1981-01-01

    This paper covers four approaches to risk assessment in the energy industry. The first is a comparison of the primary fuel cycles - coal and nuclear - standardized to 1 GW(e) power-plant year; this gives the societal risk of the production of a standardized amount of electricity. An example from underground coal mining is given to show how these estimates for the fuel cycles were made. The second approach is a comparison of the societal and individual occupational risks for different energy cycles per GWy(e). The third approach is a comparison of the societal and individual occupational risks of four different types of photovoltaic cell manufacture; this is an example of an intratechnology comparison. The fourth approach is a risk accounting method of analysis which estimates occupational health impacts for fabrication, construction, operation, and maintenance of energy technologies, and which, through an input-output model of the national economy, includes system-wide impacts as well as direct impacts of building and operating energy facilities

  16. The assessment of executive functioning in children

    OpenAIRE

    Henry, L.; Bettenay, C.

    2010-01-01

    Background: Executive functioning is increasingly seen as incorporating several component sub-skills and clinical assessments should reflect this complexity. \\ud \\ud Method: Tools for assessing executive functioning in children are reviewed within five key areas, across verbal and visuospatial abilities, with emphasis on batteries of tests. \\ud \\ud Results: There are many appropriate tests for children, although the choice is more limited for those under the age of 8 years. \\ud \\ud Conclusion...

  17. Comparative assessment of gingival thickness in pigmented and nonpigmented gingiva

    Directory of Open Access Journals (Sweden)

    Radhika Bharamappa

    2013-01-01

    Full Text Available Background: It is a known fact that clinical appearance of gingiva directly correlates with the inflammatory status of the periodontium. It has been observed that the gingival thickness (GT appears to differ in pigmented and nonpigmented gingiva. Thickness of gingiva seems to be of significance and an issue of concern in aesthetic and functional outcome of the periodontal, restorative and orthodontic therapy. So far in the periodontal literature, the gingival width has been discussed to a great extent. GT also plays an equally important role, but it has been given limited importance when compared to gingival width. Purpose of the Study: The purpose of this study was to comparatively assess the GT in pigmented and nonpigmented gingiva by transgingival probing. Materials and Methods: The study included 240 sites in 10 patients each of pigmented and nonpigmented gingiva. The GT was assessed mid-buccally in the attached gingiva, half way between mucogingival junction and free gingival groove and at the base of the interdental papilla. The gingival bleeding index and plaque index were also recorded. The data were statistically analysed using paired t-test and Z-test. Results and Conclusion: Gingival bleeding index and plaque index were similar between both the groups. Both midbuccal and interdental areas were thicker in pigmented gingiva when compared to nonpigmented gingiva.

  18. Assessing the Utility of a Demand Assessment for Functional Analysis

    Science.gov (United States)

    Roscoe, Eileen M.; Rooker, Griffin W.; Pence, Sacha T.; Longworth, Lynlea J.

    2009-01-01

    We evaluated the utility of an assessment for identifying tasks for the functional analysis demand condition with 4 individuals who had been diagnosed with autism. During the demand assessment, a therapist presented a variety of tasks, and observers measured problem behavior and compliance to identify demands associated with low levels of…

  19. Executive function in fibromyalgia: Comparing subjective and objective measures.

    Science.gov (United States)

    Gelonch, Olga; Garolera, Maite; Valls, Joan; Rosselló, Lluís; Pifarré, Josep

    2016-04-01

    There is evidence to suggest the existence of an executive dysfunction in people diagnosed with fibromyalgia, although there are certain inconsistencies between studies. Here, we aim to compare executive performance between patients with fibromyalgia and a control group by using subjective and objective cognitive tests, analyzing the influence of patient mood on the results obtained, and studying associations between the two measures. 82 patients diagnosed with fibromyalgia and 42 healthy controls, matched by age and years of education, were assessed using the Behavioral Rating Inventory of Executive Function - Adult Version (BRIEF-A) as a subjective measure of executive functioning. A selection of objective cognitive tests were also used to measure a series of executive functions and to identify symptoms of depression and anxiety. Patients with fibromyalgia perceived greater difficulties than the control group on all of the BRIEF-A scales. However, after adjustments were made for depression and anxiety the only differences that remained were those associated with the working memory scale and the Metacognition and Global Executive Composite index. In the case of the objective cognitive tests, a significantly worse overall performance was evidenced for the fibromyalgia patients. However, this also disappeared when adjustments were made for depression and anxiety. After this adjustment, fibromyalgia patients only performed significantly worse for the interference effect in the Stroop Test. Although there were no significant associations between most of the objective cognitive tests and the BRIEF-A scales, depression and anxiety exhibited strong associations with almost all of the BRIEF-A scales and with several of the objective cognitive tests. Patients with fibromyalgia showed executive dysfunction in subjective and objective measures, although most of this impairment was associated with mood disturbances. Exceptions to this general rule were observed in the

  20. Imaging and assessment of placental function.

    LENUS (Irish Health Repository)

    Moran, Mary

    2011-09-01

    The placenta is the vital support organ for the developing fetus. This article reviews current ultrasound (US) methods of assessing placental function. The ability of ultrasound to detect placental pathology is discussed. Doppler technology to investigate the fetal, placental, and maternal circulations in both high-risk and uncomplicated pregnancies is discussed and the current literature on the value of three-dimensional power Doppler studies to assess placental volume and vascularization is also evaluated. The article highlights the need for further research into three-dimensional ultrasound and alternative methods of placental evaluation if progress is to be made in optimizing placental function assessment.

  1. A novel approach to the assessment of vascular endothelial function

    International Nuclear Information System (INIS)

    Sathasivam, S; Siddiqui, Z; Greenwald, S; Phababpha, S; Sengmeuan, P; Detchaporn, P; Kukongviriyapan, U

    2011-01-01

    Impaired endothelial function (EF) is associated with atherogenesis, and its quantitative assessment has prognostic value. Currently, methods based on assessing flow-mediated dilation (FMD) are technically difficult and expensive. We tested a novel way of assessing EF by measuring the time difference between pulses arriving at the middle fingers of each hand (f-fΔT), whilst FMD is induced in one arm. We compared f-fΔT with standard methods in healthy and diseased subjects. Our findings suggest that the proposed simple and inexpensive technique gives comparable results and has the potential to qualitatively assess EF in the clinical setting, although further work is required.

  2. Assessing gene function in the ruminant placenta.

    Science.gov (United States)

    Anthony, R V; Cantlon, J D; Gates, K C; Purcell, S H; Clay, C M

    2010-01-01

    The placenta provides the means for nutrient transfer from the mother to the fetus, waste transfer from the fetus to the mother, protection of the fetus from the maternal immune system, and is an active endocrine organ. While many placental functions have been defined and investigated, assessing the function of specific genes expressed by the placenta has been problematic, since classical ablation-replacement methods are not feasible with the placenta. The pregnant sheep has been a long-standing animal model for assessing in vivo physiology during pregnancy, since surgical placement of indwelling catheters into both maternal and fetal vasculature has allowed the assessment of placental nutrient transfer and utilization, as well as placental hormone secretion, under unanesthetized-unstressed steady state sampling conditions. However, in ruminants the lack of well-characterized trophoblast cell lines and the inefficiency of creating transgenic pregnancies in ruminants have inhibited our ability to assess specific gene function. Recently, sheep and cattle primary trophoblast cell lines have been reported, and may further our ability to investigate trophoblast function and transcriptional regulation of genes expressed by the placenta. Furthermore, viral infection of the trophoectoderm layer of hatched blastocysts, as a means for placenta-specific transgenesis, holds considerable potential to assess gene function in the ruminant placenta. This approach has been used successfully to "knockdown" gene expression in the developing sheep conceptus, and has the potential for gain-of-function experiments as well. While this technology is still being developed, it may provide an efficient approach to assess specific gene function in the ruminant placenta.

  3. Determining and comparing protein function in Bacterial genome sequences

    DEFF Research Database (Denmark)

    Vesth, Tammi Camilla

    of this class have very little homology to other known genomes making functional annotation based on sequence similarity very difficult. Inspired in part by this analysis, an approach for comparative functional annotation was created based public sequenced genomes, CMGfunc. Functionally related groups......In November 2013, there was around 21.000 different prokaryotic genomes sequenced and publicly available, and the number is growing daily with another 20.000 or more genomes expected to be sequenced and deposited by the end of 2014. An important part of the analysis of this data is the functional...... annotation of genes – the descriptions assigned to genes that describe the likely function of the encoded proteins. This process is limited by several factors, including the definition of a function which can be more or less specific as well as how many genes can actually be assigned a function based...

  4. HDL functionality in South Asians as compared to white Caucasians

    NARCIS (Netherlands)

    Bakker, L. E. H.; Boon, M. R.; Annema, W.; Dikkers, A.; van Eyk, H. J.; Verhoeven, A.; Mayboroda, O. A.; Jukema, J. W.; Havekes, L. M.; Meinders, A. E.; van Dijk, K. Willems; Jazet, I. M.; Tietge, U. J. F.; Rensen, P. C. N.

    Background and Aims: South Asians have an exceptionally high risk of developing cardiovascular disease compared to white Caucasians. A contributing factor might be dysfunction of high density lipoprotein (HDL). We aimed to compare HDL function in different age groups of both ethnicities. Methods and

  5. Routine functional assessment for hip fracture patients

    DEFF Research Database (Denmark)

    Pedersen, Tonny J; Lauritsen, Jens M

    2016-01-01

    Background and purpose - Pre-fracture functional level has been shown to be a consistent predictor of rehabilitation outcomes in older hip fracture patients. We validated 4 overall pre-fracture functional level assessment instruments in patients aged 65 or more, used the prediction of outcome at 4...... months post-fracture, and assessed cutoff values for decision making in treatment and rehabilitation. Patients and methods - 165 consecutive patients with acute primary hip fracture were prospectively included in the study. Pre-fracture Barthel-20, Barthel-100, cumulated ambulation score, and new...... investigation of usage for guidance of clinical and rehabilitation decisions concerning hip fracture patients is warranted....

  6. Comparing international and South African work-based assessment ...

    African Journals Online (AJOL)

    Comparing international and South African work-based assessment of medical interns' practice. ... in the finding that most studies in SA have dealt with the assessment of core procedural skills related to acute clinical care, while the assessment of non-clinical competencies and non-procedural skills was poorly addressed.

  7. Renal function assessment in heart failure.

    Science.gov (United States)

    Pérez Calvo, J I; Josa Laorden, C; Giménez López, I

    Renal function is one of the most consistent prognostic determinants in heart failure. The prognostic information it provides is independent of the ejection fraction and functional status. This article reviews the various renal function assessment measures, with special emphasis on the fact that the patient's clinical situation and response to the heart failure treatment should be considered for the correct interpretation of the results. Finally, we review the literature on the performance of tubular damage biomarkers. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

  8. Depression in Schizophrenia: Associations With Cognition, Functional Capacity, Everyday Functioning, and Self-Assessment.

    Science.gov (United States)

    Harvey, Philip D; Twamley, Elizabeth W; Pinkham, Amy E; Depp, Colin A; Patterson, Thomas L

    2017-05-01

    Depressed mood has a complex relationship with self-evaluation of personal competence in multiple populations. The absence of depression may be associated with overestimation of abilities, while mild depression seems to lead to accurate self-assessment. Significant depression may lead to underestimation of functioning. In this study, we expand on our previous work by directly comparing the association between different levels of depression, everyday functioning, cognitive and functional capacity performance, and self-assessment of everyday functioning in a large (n = 406) sample of outpatients with schizophrenia. Participants with very low self-reported depression overestimated their everyday functioning compared with informant reports. Higher levels of depression were associated with more accurate self-assessment, but no subgroup of patients underestimated their functioning. Depressive symptom severity was associated with poorer informant-rated social functioning, but there were no differences in vocational functioning, everyday activities, cognitive performance, and functional capacity associated with the severity of self-reported depression. There was minimal evidence of impact of depression on most aspects of everyday functioning and objective test performance and a substantial relationship between depression and accuracy of self-assessment. © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  9. Functional Behavioral Assessment in Early Education Settings

    Science.gov (United States)

    Neilsen, Shelley; McEvoy, Mary

    2004-01-01

    Functional behavioral assessment (FBA) is the process of identifying the events in the environment that consistently precede and follow challenging behavior. The use of FBA has increased significantly following the reauthorization of the Individuals with Disabilities Education Act in 1997, which mandated FBAs be conducted when children with…

  10. Effects of Training in Functional Behavior Assessment

    Science.gov (United States)

    Dukes, Charles; Rosenberg, Howard; Brady, Michael

    2008-01-01

    The purpose of this study was to investigate the effectiveness of training special education teachers in the process of functional behavioral assessment (FBA) and subsequent development of recommendations to promote behavior change. An original evaluation instrument was developed that included measures of special education teachers' knowledge of…

  11. Comparative ergonomic assessment of manual wheelchairs by paraplegic users.

    Science.gov (United States)

    Gil-Agudo, Angel; Solís-Mozos, Marta; del-Ama, Antonio J; Crespo-Ruiz, Beatriz; de la Peña-González, Ana Isabel; Pérez-Nombela, Soraya

    2013-07-01

    The aim of the present study was to describe and test the reliability of a comprehensive product-centered approach to assessing functional performance and wheelchair user perceptions on device ergonomics and satisfaction of performance. A pilot study was implemented using this approach to evaluate differences among four manual wheelchairs. Six wheelchair users with complete spinal cord injury (SCI) at the thoracic level and with no previous upper limbs impairment were recruited for this study. After finishing circuit tasks, subjects were asked to complete a questionnaire about ergonomic wheelchair characteristics (manoeuvrability, stability, comfort and ease of propulsion) and satisfaction about task performance. On the other hand, objective data were recorded during user performance as the time required to complete each test, kinetic wheelchair propulsion data obtained with two SMARTWheels® and physiological parameters (heart rate and physiological index). Kuschall Champion® and Otto Bock Voyage® wheelchairs were ranked best for most ergonomic aspects specially in manoeuvrability (p importance of looking both kinds of information, user perception and user functional performance when evaluating a wheelchair or comparing across devices.

  12. Assessment of functional vision and its rehabilitation.

    Science.gov (United States)

    Colenbrander, August

    2010-03-01

    This article, based on a report prepared for the International Council of Ophthalmology (ICO) and the International Society for Low Vision Research and Rehabilitation (ISLRR), explores the assessment of various aspects of visual functioning as needed to document the outcomes of vision rehabilitation. Documenting patient abilities and functional vision (how the person functions) is distinct from the measurement of visual functions (how the eye functions) and also from the assessment of quality of life. All three areas are important, but their assessment should not be mixed. Observation of task performance offers the most objective measure of functional vision, but it is time-consuming and not feasible for many tasks. Where possible, timing and error rates provide an easy score. Patient response questionnaires provide an alternative. They may save time and can cover a wider area, but the responses are subjective and proper scoring presents problems. Simple Likert scoring still predominates but Rasch analysis, needed to provide better result scales, is gaining ground. Selection of questions is another problem. If the range of difficulties does not match the range of patient abilities, and if the difficulties are not distributed evenly, the results are not optimal. This may be an argument to use different outcome questions for different conditions. Generic questionnaires are appropriate for the assessment of generic quality of life, but not for specific rehabilitation outcomes. Different questionnaires are also needed for screening, intake and outcomes. Intake questions must be relevant to actual needs to allow prioritization of rehabilitation goals; the activity inventory presents a prototype. Outcome questions should be targeted at predefined rehabilitation goals. The Appendix cites some promising examples. The Low Vision Intervention Trial (LOVIT) is an example of a properly designed randomized control study, and has demonstrated the remarkable effectiveness of

  13. Compare of Executive Function in Bipolar I Disorder and Schizophrenia

    Directory of Open Access Journals (Sweden)

    Mohammad Reza khodaei-Ardakani

    2013-10-01

    Full Text Available Objective: There is evidence for differential executive function in Bipolar I Disorder (BID and schizophrenia that may tend different cognitive deficits and abnormalities. The objective of this sudsy was to compare the executive function of BID and schizophrenic patients. Materials & Methods: We studied 50 patients with BID, and 50 with schizophrenia participants in outpatients' clinic of Rouzbeh hospital. All participants completed the Wisconsin Card Sorting Test (WCST the Persian version. The participants were mach in three basic variables which had most contributions in cognitive conditions in patients. They were Age, educational status and period of illness. Results: The two patient groups had compared performance on the WCST in compared with general population (P<0/05. In the WCST, schizophrenic patients showed impairment executive function than BID patients (P<0/05. Conclusion: findings indicated that schizophrenic patients had more dysfunctions executive function than the Bipolar disorder I patients. Although, both disorders may show impairment in executive function, but the dysfunction in schizophrenia greater than Bipolar I Disorder patients.

  14. Assessing functional diversity by program slicing

    International Nuclear Information System (INIS)

    Wallace, D.R.; Lyle, J.R.; Gallagher, K.B.; Ippolito, L.M.

    1994-01-01

    A responsibility of the Nuclear Regulatory Commission auditors is to provide assessments of the quality of the safety systems. For software, the audit process as currently implemented is a slow, tedious, manual process prone to human errors. While auditors cannot possibly examine all components of the system in complete detail, they do check for implementation of specific principles like functional diversity. This paper describes an experimental prototype Computer Aided Software Engineering (CASE) tool, UNRAVEL, designed to enable auditors to check for functional diversity and aid an auditor in examining software by extracting all code relevant to a computation identified for detailed inspection

  15. Comparative Assessment of Knowledge, Attitude and Practice of ...

    African Journals Online (AJOL)

    TNHJOURNALPH

    screening among female clinical nursing students in Southern Nigeria. ... female clinical nursing students in Delta. State University ... and drastic intervention strategies to save our women from unnecessary death. KEYWORDS. Comparative Assessment; Cervical cancer; Southern Nigeria. Correspondence: Dr. R. U. lbekwe.

  16. Comparative Assessment of Health Workers Performance and The ...

    African Journals Online (AJOL)

    Comparative Assessment of Health Workers Performance and The Performance ... had very high significant effect on performance of health workers which was independent of ... Keywords: Health Worker Performance Factors Hospitals Nigeria ...

  17. Platelet function in brown bear (Ursus arctos compared to man

    Directory of Open Access Journals (Sweden)

    Särndahl Eva

    2010-06-01

    Full Text Available Abstract Background Information on hemostasis and platelet function in brown bear (Ursus arctos is of importance for understanding the physiological, protective changes during hibernation. Objective The study objective was to document platelet activity values in brown bears shortly after leaving the den and compare them to platelet function in healthy humans. Methods Blood was drawn from immobilized wild brown bears 7-10 days after leaving the den in mid April. Blood samples from healthy human adults before and after clopidogrel and acetylsalicylic acid administration served as control. We analyzed blood samples by standard blood testing and platelet aggregation was quantified after stimulation with various agonists using multiple electrode aggregometry within 3 hours of sampling. Results Blood samples were collected from 6 bears (3 females between 1 and 16 years old and from 10 healthy humans. Results of adenosine diphosphate, aspirin, and thrombin receptor activating peptide tests in bears were all half or less of those in humans. Platelet and white blood cell counts did not differ between species but brown bears had more and smaller red blood cells compared with humans. Conclusion Using three different tests, we conclude that platelet function is lower in brown bears compared to humans. Our findings represent the first descriptive study on platelet function in brown bears and may contribute to explain how bears can endure denning without obvious thrombus building. However, the possibility that our findings reflect test-dependent and not true biological variations in platelet reactivity needs further studies.

  18. Comparative risk assessments for Guadeloupe: earthquakes and storm surge

    OpenAIRE

    Réveillère , Arnaud; Monfort , Daniel; Lecacheux , Sophie; Grisanti , Ludovic; Muller , Héloise; Bertil , Didier; Rohmer , Jérémy; Sedan , Olivier; Douglas , John; Baills , Audrey; Modaressi , Hormoz

    2012-01-01

    In France, risk assessments for natural hazards are usually carried out separately and decision makers lack comprehensive information. Moreover, since the cause of the hazard (e.g. meteorological, geological) and the physical phenomenon that causes damage (e.g. inundation, ground shaking) may be fundamentally different, the quantitative comparison of single risk assessments that were not conducted in a compatible framework is not straightforward. Comprehensive comparative risk assessments exi...

  19. The comparative risk assessment framework and tools (CRAFT)

    Science.gov (United States)

    Southern Research Station. USDA Forest Service

    2010-01-01

    To help address these challenges, the USDA Forest Service’s Eastern Forest Environmental Threat Assessment Center (EFETAC) and the University of North Carolina Asheville’s National Environmental Modeling and Analysis Center (NEMAC) designed a planning framework, called the Comparative Risk Assessment Framework and Tools (CRAFT). CRAFT is...

  20. The use of comparative risk assessment in decision making

    International Nuclear Information System (INIS)

    Chicken, J.C.; Hayns, M.R.; Tolley, B.

    1989-01-01

    This paper justifies: 1) Comparative risk assessment provides a way of establishing whether or not the risks associated with a novel proposal are likely to satisfy current norms. 2) Comparative risk assessment is an aid to decision making when for some reason there is inadequate quantitative data about the risks associated with a project. 3) One problem is that there is no single universally acceptable norm. Norms vary both with time and from activity to activity. The spread of acceptable norms spans at least two orders of magnitude. 4) For any comparative risk assessment to be considered more than a suggestion on how acceptable a risk is, the risks that are compared must be similar and located in similar cultural and geographical environments. 5) Ulitmately justification of the acceptability of a project must be based on data generated directly by the project itself and any opinion based on comparative evidence must be iteratively revised as direct hard evidence becomes available. 6) Comparative risk assessment has a useful role in presentations to the lay public about the acceptability of a particular risk. 7) There may be more problems in making a comparative assessment of risk acceptability in socio-political terms than in technical or economic terms. The central requirement that the comparison must be based on data from similar cultural backgrounds is often hard to satisfy in relation to socio-political considerations

  1. [Assessment of cognitive functions in internal medicine].

    Science.gov (United States)

    Capron, J

    2015-12-01

    The evaluation of cognitive functions can be performed using two approaches: a quantitative one, based on screening tools; a qualitative one, based on the examination of specific cognitive functions. The quantitative approach offers a pragmatic process: to screen rapidly for a cognitive dysfunction that may require assistance or treatments. We will present three screening tools and their diagnostic value: the clock test, the Mini Mental State Examination and the Montreal Cognitive Assessment. They help select patients who require a more detailed examination to precisely diagnose their cognitive dysfunction. We propose a way to perform a detailed cognitive examination at the bedside, including the examination of alertness, attention, memory, language, frontal functions, praxis and hemi-neglect. This simple examination indicates the location of the cerebral lesion and sometimes suggests the underlying disease. Copyright © 2015. Published by Elsevier SAS.

  2. COMPLEX FUNCTIONAL ASSESSMENT OF THE HIP JOINT.

    Directory of Open Access Journals (Sweden)

    Maya S. Krastanova

    2015-09-01

    Full Text Available Introduction: In relation to the study reporting the effects of applying phased complex rehabilitation in patients with total hip arthroplasty, it has been concluded that the everyday clinical practice in Bulgaria does not apply complex examination, giving an objective picture about the extent of functional status of patients with trauma and diseases of the hip. Aim: The main goal of this report is to present a test which incorporates all known and routine research and in which the total number of points determines the functional status of patients with trauma and diseases of the hip. Material and Methods: Based on the Hip dysfunction and Osteoarthritis Outcome Score, the Harris Hip Score modified test, scale D’Aubigne and Postel and Iowa’s test for complex functional evaluation of the hip joint, we have developed a test including information about the degree of pain; goniometry and manual muscle testing of the hip; locomotor test – type of gait and adjuvants; test for Daily Activities of Life. The test has been developed on the basis of expert assessment by doctors and physiotherapists of the proposed indicators for evaluation and determination of the weighting factors’ contribution to the general condition of the patient. Conclusion: The developed and tested method of complex functional assessment of the hip joint enables our colleagues, dealing with trauma and diseases of the hip, to use it in various research and scientific projects, as well as in general medical practice.

  3. A global assessment of Holistic Planned Grazing™ compared with ...

    African Journals Online (AJOL)

    Previous reviews have found similar or greater plant and animal production in continuous (season-long) compared with rotational grazing. Here season-long continuous grazing is compared with HPG alone to explore the evidence for animal impact. Three quantitative meta-analysis models were used to assess data sets ...

  4. Comparative life cycle assessment of industrial multi-product processes

    OpenAIRE

    Jung, Johannes

    2014-01-01

    The demand for environmentally safe industrial processes is increasing. Therefore, environmental impacts of new processes have to be examined at an early stage. A method for analyzing environmental impacts is life cycle assessment (LCA). A major trouble of LCA are multi-functionality problems. Multi-functionality problems can be fixed using alternative methods such as system expansion, avoided burden and allocation. Each of the three methods requires choices by the LCA-practitioner. The choic...

  5. Comparative thermal buckling analysis of functionally graded plate

    Directory of Open Access Journals (Sweden)

    Čukanović Dragan V.

    2017-01-01

    Full Text Available A thermal buckling analysis of functionally graded thick rectangular plates accord¬ing to von Karman non-linear theory is presented. The material properties of the functionally graded plate, except for the Poisson’s ratio, were assumed to be graded in the thickness direction, according to a power-law distribution, in terms of the volume fractions of the metal and ceramic constituents. Formulations of equilibrium and stability equations are derived using the high order shear deformation theory based on different types of shape functions. Analytical method for determination of the critical buckling temperature for uniform increase of temperature, linear and non-linear change of temperature across thickness of a plate is developed. Numeri¬cal results were obtained in МATLAB software using combinations of symbolic and numeric values. The paper presents comparative results of critical buckling tempera¬ture for different types of shape functions. The accuracy of the formulation presented is verified by comparing to results available from the literature.

  6. Experimental Investigations to Enhance the Tribological Performance of Engine Oil by Using Nano-Boric Acid and Functionalized Multiwalled Carbon Nanotubes: A Comparative Study to Assess Wear in Bronze Alloy

    Science.gov (United States)

    Ajay Vardhaman, B. S.; Amarnath, M.; Ramkumar, J.; Rai, Prabhat K.

    2018-04-01

    In various mechanical systems, lubricants are generally used to reduce friction and wear; thus, the total energy loss in the mechanical systems can be minimized by the proper enhancement of lubrication properties. In general, friction modifiers and antiwear additives are used to improve the tribological properties of the lubricant. However, the use of these additives has to be phased out due to their fast chemical degradation in their applications and other environmental issues. In recent years, the use of nanoparticles as a potential lubricant additive has received considerable attention because of its excellent mechanical and tribological characteristics. The present work describes the tribological behavior of nano-boric acid, multiwalled carbon nanotubes (MWCNTs), and functionalized multiwalled carbon nanotubes (FMWCNTs) modified with carboxylic acid. These nanoparticles were used to enhance the tribological properties of engine oil (SAE20W40) used to lubricate bronze alloy samples. The performance of these nano-coolants was assessed on a linear reciprocating ball-on-flat tribometer. Results highlight the friction and wear behavior of the nano-boric acid, MWCNTs, and FMWCNTs under three varying parameters such as the effect of nanoparticles concentration, load-carrying capacity, and sliding speed. The addition of nano-boric acid, MWCNTs, and FMWCNTs has significantly improved the tribological properties of the base lubricant. The addition of 0.5 wt.% of nano-boric acid, MWCNTs, and FMWCNTs to the base lubricant has decreased the coefficient of friction by 19.76, 30.55, and 35.65%, respectively, and a significant reduction in wear volume by 55.17, 71.42, and 88.97% was obtained in comparison with base lubricant.

  7. Validating the JobFit system functional assessment method

    Energy Technology Data Exchange (ETDEWEB)

    Jenny Legge; Robin Burgess-Limerick

    2007-05-15

    Workplace injuries are costing the Australian coal mining industry and its communities $410 Million a year. This ACARP study aims to meet those demands by developing a safe, reliable and valid pre-employment functional assessment tool. All JobFit System Pre-Employment Functional Assessments (PEFAs) consist of a musculoskeletal screen, balance test, aerobic fitness test and job-specific postural tolerances and material handling tasks. The results of each component are compared to the applicant's job demands and an overall PEFA score between 1 and 4 is given with 1 being the better score. The reliability study and validity study were conducted concurrently. The reliability study examined test-retest, intra-tester and inter-tester reliability of the JobFit System Functional Assessment Method. Overall, good to excellent reliability was found, which was sufficient to be used for comparison with injury data for determining the validity of the assessment. The overall assessment score and material handling tasks had the greatest reliability. The validity study compared the assessment results of 336 records from a Queensland underground and open cut coal mine with their injury records. A predictive relationship was found between PEFA score and the risk of a back/trunk/shoulder injury from manual handling. An association was also found between PEFA score of 1 and increased length of employment. Lower aerobic fitness test results had an inverse relationship with injury rates. The study found that underground workers, regardless of PEFA score, were more likely to have an injury when compared to other departments. No relationship was found between age and risk of injury. These results confirm the validity of the JobFit System Functional Assessment method.

  8. Comparative environmental life cycle assessment of composite materials

    International Nuclear Information System (INIS)

    De Vegt, O.M.; Haije, W.G.

    1997-12-01

    The aim of the present study is to compare and quantify the environmental impact of three rotorblades made of different materials and to establish which stage in the life cycle contributes most. The life cycle of a product can be represented by the production phase, including depletion of raw materials (mining) and production (machining) of products, the utilisation phase, including use of energy, maintenance and cleaning, and the disposal phase, including landfill, incineration, recycling, etc. The environmental impact of a product is not only determined by the materials selected but also by the function of the product itself. E.g. when natural fibres are applied in vehicles as a substitution for metals the environmental impact in the use phase will be reduced due to a lower energy consumption caused by a lower car weight. The influence on the environmental impact of the production phase must also be taken into account. The material relation between the production phase and the use phase and the disposal phase is complicated. In general the lifetime of a product use phase can be extended (positive aspect), e.g. by application of a coating onto the surface. Due to the coating the product can not easily be recycled, which is a negative aspect. The three types of composites used in the rotorblade of the wind energy converter considered in this study are: flaxfibre reinforced epoxy, carbon fibre reinforced epoxy and glassfibre reinforced polyester. The assessment is performed using the computer program Simapro 3, which is based on the Dutch CML method for the environmental life-cycle assessment of products using the Eco-Indicator 95 evaluation method. The CML method defines five phases for an LCA: goal definition and scoping; inventory; classification; impact assessment; and improvement analysis. The improvement analysis is not part of this work. Performing an LCA is a time-consuming process due to the detailed information that is required. In chapter five some

  9. Functional Treatment Comparing with Immobilization after Acute Ankle Sprain

    Directory of Open Access Journals (Sweden)

    Hamidreza Mohammadi

    2013-02-01

    Full Text Available Background: Ankle injuries are among the most prevalent injuries with which a physician may encounter. In this study, the efficiency of the functional treatment was compared with the immobilization treatment in healing the acute ankle sprain. Materials and Methods: This clinical trial study was carried out on 100 male patients whose ankle sprain had been diagnosed by Yasuj Shahid Beheshti Hospital. Using block allocation randomization method and regardless of damage degree, patients were divided into two groups, functional method (1st group or immobilization with plaster (2nd group, for treatment. Several variables such as range of motion, pain intensity, inflammation, joint tenderness and returning to work after 2, 6 and 12 weeks were examined. Results: After two weeks, the average pain intensity in the first group (33.2±3.2 has been decreased compared to the second group (55±1.2, which showed a significant difference between the two groups (p<0.05. The average ankle range of motion in the first and second groups was 29.08±1.2 degrees and 20.4±2.2 degrees, respectively which had been increased significantly in the first group compared to the second group (p<0.03. Similarly, a considerable difference was observed in decreased inflammation and tenderness in the first group compared to the second one. Conclusion: In acute ankle sprains, the functional treatment is better than the immobilization treatment in alleviating pain, inflammation and improving the range of joint motion.

  10. A comparative view of the new journal: Assessment.

    Science.gov (United States)

    Blashfield, R K; Archer, G

    2001-09-01

    The reference sections from all articles in the 1997 volumes of Assessment, Journal of Personality Assessment, and Psychological Assessment were entered into a database and analyzed. An article published in Assessment averaged almost 31 references. An article published in Journal of Personality Assessment contained an average of 33 references. Psychological Assessment averaged 38 references per article. The median age of the references in the three journals was 8 years with an interquartile range of 4 to 14 years. The Journal of Personality Assessment had the largest number of citations in this database of 5,316 references. Each of these received a relatively large number of their citations from articles published in the same journal (self-citations). Randomly selected articles from the 1997 volume of Assessment received fewer citations in the Social Science Citation Index than a similar set of articles from the other two journals. However, the data on Assessment, when compared with data available on other new scientific publications, suggests that Assessment is doing as well as other fledgling journals.

  11. Imbalanced Learning for Functional State Assessment

    Science.gov (United States)

    Li, Feng; McKenzie, Frederick; Li, Jiang; Zhang, Guangfan; Xu, Roger; Richey, Carl; Schnell, Tom

    2011-01-01

    This paper presents results of several imbalanced learning techniques applied to operator functional state assessment where the data is highly imbalanced, i.e., some function states (majority classes) have much more training samples than other states (minority classes). Conventional machine learning techniques usually tend to classify all data samples into majority classes and perform poorly for minority classes. In this study, we implemented five imbalanced learning techniques, including random undersampling, random over-sampling, synthetic minority over-sampling technique (SMOTE), borderline-SMOTE and adaptive synthetic sampling (ADASYN) to solve this problem. Experimental results on a benchmark driving lest dataset show thai accuracies for minority classes could be improved dramatically with a cost of slight performance degradations for majority classes,

  12. A Comparative Study on Optimal Structural Dynamics Using Wavelet Functions

    Directory of Open Access Journals (Sweden)

    Seyed Hossein Mahdavi

    2015-01-01

    Full Text Available Wavelet solution techniques have become the focus of interest among researchers in different disciplines of science and technology. In this paper, implementation of two different wavelet basis functions has been comparatively considered for dynamic analysis of structures. For this aim, computational technique is developed by using free scale of simple Haar wavelet, initially. Later, complex and continuous Chebyshev wavelet basis functions are presented to improve the time history analysis of structures. Free-scaled Chebyshev coefficient matrix and operation of integration are derived to directly approximate displacements of the corresponding system. In addition, stability of responses has been investigated for the proposed algorithm of discrete Haar wavelet compared against continuous Chebyshev wavelet. To demonstrate the validity of the wavelet-based algorithms, aforesaid schemes have been extended to the linear and nonlinear structural dynamics. The effectiveness of free-scaled Chebyshev wavelet has been compared with simple Haar wavelet and two common integration methods. It is deduced that either indirect method proposed for discrete Haar wavelet or direct approach for continuous Chebyshev wavelet is unconditionally stable. Finally, it is concluded that numerical solution is highly benefited by the least computation time involved and high accuracy of response, particularly using low scale of complex Chebyshev wavelet.

  13. Comparative studies of brain activation with MEG and functional MRI

    International Nuclear Information System (INIS)

    George, J.S.; Aine, C.J.; Sanders, J.A.; Lewine, J.D.; Caprihan, A.

    1993-01-01

    The past two years have witnessed the emergence of MRI as a functional imaging methodology. Initial demonstrations involved the injection of a paramagnetic contrast agent and required ultrafast echo planar imaging capability to adequately resolve the passage of the injected bolus. By measuring the local reduction in image intensity due to magnetic susceptibility, it was possible to calculate blood volume, which changes as a function of neural activation. Later developments have exploited endogenous contrast mechanisms to monitor changes in blood volume or in venous blood oxygen content. Recently, we and others have demonstrated that it is possible to make such measurements in a clinical imager, suggesting that the large installed base of such machines might be utilized for functional imaging. Although it is likely that functional MRI (fMRI) will subsume some of the clinical and basic neuroscience applications now touted for MEG, it is also clear that these techniques offer different largely complementary, capabilities. At the very least, it is useful to compare and cross-validate the activation maps produced by these techniques. Such studies will be valuable as a check on results of neuromagnetic distributed current reconstructions and will allow better characterization of the relationship between neurophysiological activation and associated hemodynamic changes. A more exciting prospect is the development of analyses that combine information from the two modalities to produce a better description of underlying neural activity than is possible with either technique in isolation. In this paper we describe some results from initial comparative studies and outline several techniques that can be used to treat MEG and fMRI data within a unified computational framework

  14. International conference on comparative assessments of solar power technologies

    International Nuclear Information System (INIS)

    Roy, A.

    1994-02-01

    Many regions in the world which lack fossil fuel resources but possess ample sunshine seek to identify near-term solar technologies capable of gradually replacing their fuel imports in cost-effective fashion. The conference addresses the following topics: technical and economical studies specifying their underlying basic assumption, methods and rules for evaluation in order to enable meaningful comparison between different technologies and systems. Detailed delineation of numerical and graphical representations, critical analysis and comparison between simulations, and test validity. Generalized performance indicators for systems and subsystems, problems of measuring and evaluating physical parameters, of terminology and conceptual tools for comparative evaluations. Advances in research development, engineering and field performance, including implications pertaining to comparative assessments and definitions of criteria and standards helpful to comparative evaluation. Assessments of the full (and hidden) cost of fossil energies as compared to solar, including environmental costs. Cost/benefit studies for remote versus centralized systems. (ed.)

  15. Life event stress in duodenal ulcer compared with functional dyspepsia: A case-control study

    OpenAIRE

    Abdel Hafeiz Hassan; Al Quorain Abdulaziz; Karim Ahmed; Al-Mangoor Shuaa

    1997-01-01

    This is a prospective study of life event stress in 80 duodenal ulcer patients compared with 80 patients with functional dyspepsia and 80 healthy controls; matched for age, sex and marital status. A semi structured psychiatric interview was used in the psychiatric assessment of the dyspeptic patients and controls. A modified version of Life Events Scale by Tennant and Andrews was used in the assessment of life event stress. More dyspeptic patients reported life events than the controls, but, ...

  16. Comparative responsiveness of measures of pain and function after total hip replacement

    DEFF Research Database (Denmark)

    Nilsdotter, A K; Roos, Ewa M.; Westerlund, J P

    2001-01-01

    To compare the responsiveness of the Functional Assessment System (FAS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Medical Outcomes Study 36-item Short Form (SF-36) in patients with osteoarthritis (OA) scheduled for total hip replacement....

  17. Effect of orthostasis on endothelial function: a gender comparative study.

    Directory of Open Access Journals (Sweden)

    Nandu Goswami

    Full Text Available As the vascular endothelium has multiple functions, including regulation of vascular tone, it may play a role in the pathophysiology of orthostatic intolerance. We investigated the effect of orthostasis on endothelial function using EndoPAT®, a non-invasive and user-independent method, and across gender. As sex steroid hormones are known to affect endothelial function, this study examined the potential effect of these hormones on the endothelial response to orthostasis by including females at different phases of the menstrual cycle (follicular and luteal-where the hormone balance differs, and females taking an oral contraceptive. A total of 31 subjects took part in this study (11 males, 11 females having normal menstrual cycles and 9 females taking oral contraceptive. Each subject made two visits for testing; in the case of females having normal menstrual cycles the first session was conducted either 1-7 (follicular or 14-21 days (luteal after the start of menstruation, and the second session two weeks later, i.e., during the other phase, respectively. Endothelial function was assessed at baseline and following a 20-min orthostatic challenge (active standing. The EndoPAT® index increased from 1.71 ± 0.09 (mean ± SEM at baseline to 2.07 ± 0.09 following orthostasis in females (p<0.001. In males, the index increased from 1.60 ± 0.08 to 1.94 ± 0.13 following orthostasis (p<0.001. There were no significant differences, however, in the endothelial response to orthostasis between females and males, menstrual cycle phases and the usage of oral contraceptive. Our results suggest an increased vasodilatatory endothelial response following orthostasis in both females and males. The effect of gender and sex hormones on the endothelial response to orthostasis appears limited. Further studies are needed to determine the potential role of this post orthostasis endothelial response in the pathophysiology of orthostatic intolerance.

  18. Functional assessment of cutaneous microvasculature after radiation

    International Nuclear Information System (INIS)

    Doll, C.; Durand, R.; Grulkey, W.; Sayer, S.; Olivotto, I.

    1999-01-01

    Background and purpose: To determine if laser Doppler flowmetry could be used to non-invasively evaluate microvasculature function after radiation therapy (RT), we assessed blood flow response to heating in women following RT after breast conservation.Materials and methods: Forty women with unilateral stage I/II breast cancer treated with conservative surgery and RT were evaluated at varying intervals post RT. Ten patients were retested after an interval of 55 to 57 months to assess reproducibility of the control data. A laser Doppler probe fitted into a heat source was used to non-invasively measure blood flow in a small area of skin on the treated breast and a matched area on the untreated side. The heating element increased skin surface temperature to 40C, permitting assessment of heat stress induced changes in blood flow.Results36 months post RT, there was no significant difference seen in relative blood flow between the irradiated and non-irradiated sides. Cutaneous blood flow response to the heat stress was very reproducible when women were reassessed 55 to 57 months after initial testing.Conclusions 36 months post RT. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  19. Cognitive, functional and behavioral assessment: Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Márcia L.F. Chaves

    Full Text Available Abstract A review of the evidence on cognitive, functional and behavioral assessment for the diagnosis of dementia due to Alzheimer's disease (AD is presented with revision and broadening of the recommendations on the use of tests and batteries in Brazil for the diagnosis of dementia due to AD. A systematic review of the literature (MEDLINE, LILACS and SCIELO database was carried out by a panel of experts. Studies on the validation and/or adaptation of tests, scales and batteries for the Brazilian population were analyzed and classified according to level of evidence. There were sufficient data to recommend the IQCODE, DAFS-R, DAD, ADL-Q and Bayer scale for the evaluation of instrumental activities of daily living, and the Katz scale for the assessment of basic activities of daily living. For the evaluation of neuropsychiatric symptoms, the Neuropsychiatric Inventory (NPI and the CAMDEX were found to be useful, as was the Cornell scale for depression in dementia. The Mini-Mental State Examination has clinical utility as a screening test, as do the multifunctional batteries (CAMCOG-R, ADAS-COG, CERAD and MDRS for brief evaluations of several cognitive domains. There was sufficient evidence to recommend the CDR scale for clinical and severity assessment of dementia. Tests for Brazilian Portuguese are recommended by cognitive domain based on available data.

  20. Comparative cytotoxicity assessments of some manufactured and anthropogenic nanoparticulate materials

    Science.gov (United States)

    Soto, Karla Fabiola

    toxicity evaluation, cytokine production, mitochondrial function (MTT assay), reactive oxygen species generation (ROS), were assessed after 48 and 336 hours under control and exposed conditions. A simple, direct-contact assay was developed to evaluate the toxicity of anthropogenic particulate matter (PM), without removing it from high volume filter collections and exposing collected PM by direct contact with the human epithelial (A549) cells in culture. The cell viability data revealed that the manufactured nanomaterials exhibit cytotoxic response for the murine alveolar and human macrophage cell line, but in particular to the human epithelial cell line. Assay results for the direct-contact of filter-collected carbonaceous nanoparticulate, showed toxicity for all PM, but with various natural gas combustion PM being the most toxic. Light optical microscopy examination of affected human epithelial cells confirmed quantitative results. These nanoparticulate soots also produced the most reactive oxygen species (ROS) on the A549 cell culture as well as along with the Fe2O3, MWCNT-N, and black carbon (BC). Comparison of polycyclic aromatic hydrocarbon (PAH) content and concentration for the carbonaceous PM showed no PAH correlation with relative cell viability after 48 h. In addition, there was no correlation of cytotoxic response with specific surface area in the manufactured nanoparticulate materials. In conclusion, the manufactured as well as the anthropogenic nanomaterials were observed to generate large amounts of ROS and cytokines. This study suggests that the mechanism of toxicity is likely due to the generation of reactive oxygen species (ROS). Also, the comparative assessments presented, should be viewed as a precaution when considering the inhalation of the corresponding nanoparticulate materials in concentrations approaching those identified to be dangerous for recognized pathogens such as silica, black carbon, and asbestos. Humans should avoid breathing these

  1. A comparative study assessing a new tool for occluding ...

    African Journals Online (AJOL)

    0.630, p=0.068 and p=0.047, respectively) (Table 2). A comparative study assessing a new tool for occluding parenchymal blood flow during liver resection for hepatocellular carcinoma. S Zhou, X-J Xue, R-R Li, D-F Chen, W-Y Chen, G-X Liu, ...

  2. Comparative assessment of the nutritional contents and sensory ...

    African Journals Online (AJOL)

    The objectives of this study was to comparatively assess the dry matter, nutritive value and sensory properties of cheese produced from cow and sheep milk using three different local coagulants of plant origin: Calotropis procera leaf extract, Carica papaya leaf extract and lemon fruit juice. The following proximate and ...

  3. Comparative and Predictive Multimedia Assessments Using Monte Carlo Uncertainty Analyses

    Science.gov (United States)

    Whelan, G.

    2002-05-01

    Multiple-pathway frameworks (sometimes referred to as multimedia models) provide a platform for combining medium-specific environmental models and databases, such that they can be utilized in a more holistic assessment of contaminant fate and transport in the environment. These frameworks provide a relatively seamless transfer of information from one model to the next and from databases to models. Within these frameworks, multiple models are linked, resulting in models that consume information from upstream models and produce information to be consumed by downstream models. The Framework for Risk Analysis in Multimedia Environmental Systems (FRAMES) is an example, which allows users to link their models to other models and databases. FRAMES is an icon-driven, site-layout platform that is an open-architecture, object-oriented system that interacts with environmental databases; helps the user construct a Conceptual Site Model that is real-world based; allows the user to choose the most appropriate models to solve simulation requirements; solves the standard risk paradigm of release transport and fate; and exposure/risk assessments to people and ecology; and presents graphical packages for analyzing results. FRAMES is specifically designed allow users to link their own models into a system, which contains models developed by others. This paper will present the use of FRAMES to evaluate potential human health exposures using real site data and realistic assumptions from sources, through the vadose and saturated zones, to exposure and risk assessment at three real-world sites, using the Multimedia Environmental Pollutant Assessment System (MEPAS), which is a multimedia model contained within FRAMES. These real-world examples use predictive and comparative approaches coupled with a Monte Carlo analysis. A predictive analysis is where models are calibrated to monitored site data, prior to the assessment, and a comparative analysis is where models are not calibrated but

  4. Route assessment using comparative risk factors integrated through a GIS

    International Nuclear Information System (INIS)

    Toth, D.M.; O'Connell, W.J.

    1996-01-01

    The assessment of potential alternative routes for the shipment of spent nuclear fuel was simplified through the use of comparative risk factors evaluated using detailed route and environmental attributes. The route characteristics, integrated into risk measures, vary strongly with location and were developed from national, state, and local sources. The route data and evaluation were managed using a geographic information system (GIS). An assessment of four real North Florida routes was performed and an interstate highway route exhibited the lowest risk based on the application of the risk factors

  5. A Powerful Test for Comparing Multiple Regression Functions.

    Science.gov (United States)

    Maity, Arnab

    2012-09-01

    In this article, we address the important problem of comparison of two or more population regression functions. Recently, Pardo-Fernández, Van Keilegom and González-Manteiga (2007) developed test statistics for simple nonparametric regression models: Y(ij) = θ(j)(Z(ij)) + σ(j)(Z(ij))∊(ij), based on empirical distributions of the errors in each population j = 1, … , J. In this paper, we propose a test for equality of the θ(j)(·) based on the concept of generalized likelihood ratio type statistics. We also generalize our test for other nonparametric regression setups, e.g, nonparametric logistic regression, where the loglikelihood for population j is any general smooth function [Formula: see text]. We describe a resampling procedure to obtain the critical values of the test. In addition, we present a simulation study to evaluate the performance of the proposed test and compare our results to those in Pardo-Fernández et al. (2007).

  6. Comparing Physics Textbooks in Terms of Assessment and Evaluation Tools

    Directory of Open Access Journals (Sweden)

    Zeynep Başkan Takaoğlu

    2017-10-01

    Full Text Available Assessment and evaluation instruments provide teachers the opportunity of shaping education in the beginning, contributing to education during the process and evaluating education at the end of the process. Textbooks, on the other hand, are resources that present the aforementioned contributions to teachers at first hand. Thus, the study aims to compare the distribution of assessment and evaluation instruments in the physics textbooks being used in the academic year of 2011- 2012 and 2016-2017 according to units, settlement within units and types of assessment instruments that are used. For that purpose, 9, 10, 11 and 12th grade textbooks being used in physics lessons in the academic year of 2011-2012 and 2016-2017 were examined via document analysis method. As a result of the study, it was determined that the highest number of assessment instruments in physics textbooks from two different years was encountered in the unit of force and motion. The reason for this unit having higher number of questions could be associated with higher number of mathematical operations in the unit intended for allowing students to overcome their mathematical deficiencies by practicing such questions. It was observed that the number of questions was increased especially in the books being used in the academic year of 2016-2017 and alternative assessment instruments were fewer than traditional assessment instruments. Traditional assessment instruments are still used very frequently in the textbooks, which proves the effect of traditional approaches in assessment and evaluation. Another reason for this condition is that a result-oriented evaluation is used in the university entrance exam. In the light of these results, it is suggested to make the university exam student-centered rather than making an arrangement in textbooks.

  7. A comparative evaluation of five human reliability assessment techniques

    International Nuclear Information System (INIS)

    Kirwan, B.

    1988-01-01

    A field experiment was undertaken to evaluate the accuracy, usefulness, and resources requirements of five human reliability quantification techniques (Techniques for Human Error Rate Prediction (THERP); Paired Comparisons, Human Error Assessment and Reduction Technique (HEART), Success Liklihood Index Method (SLIM)-Multi Attribute Utility Decomposition (MAUD), and Absolute Probability Judgement). This was achieved by assessing technique predictions against a set of known human error probabilities, and by comparing their predictions on a set of five realistic Probabilisitc Risk Assessment (PRA) human error. On a combined measure of accuracy THERP and Absolute Probability Judgement performed best, whilst HEART showed indications of accuracy and was lower in resources usage than other techniques. HEART and THERP both appear to benefit from using trained assessors in order to obtain the best results. SLIM and Paired Comparisons require further research on achieving a robust calibration relationship between their scale values and absolute probabilities. (author)

  8. Uncertainty propagation in probabilistic risk assessment: A comparative study

    International Nuclear Information System (INIS)

    Ahmed, S.; Metcalf, D.R.; Pegram, J.W.

    1982-01-01

    Three uncertainty propagation techniques, namely method of moments, discrete probability distribution (DPD), and Monte Carlo simulation, generally used in probabilistic risk assessment, are compared and conclusions drawn in terms of the accuracy of the results. For small uncertainty in the basic event unavailabilities, the three methods give similar results. For large uncertainty, the method of moments is in error, and the appropriate method is to propagate uncertainty in the discrete form either by DPD method without sampling or by Monte Carlo. (orig.)

  9. FEATURES OF COMPARATIVE APPROACH TO ASSESSMENT OF THE ACQUIRED COMPANY

    Directory of Open Access Journals (Sweden)

    Olga A. Romanenko

    2013-01-01

    Full Text Available The technique of an assessment of business within the comparative approach based on four consecutive stages is considered in the article. As a result of research the contents and an analysis algorithm of each stage are in detail stated for objectivity of receiving the effective final result. The practical importance of research is that the received conclusions will allow financial managers and investors to raise validity of managing decisions concerning transactions in the market of corporate control.

  10. Independence and the Irish Environmental Protection Agency: A Comparative Assessment

    OpenAIRE

    Shipan, Charles

    2006-01-01

    The Environmental Protection Agency is one of the most prominent regulatory agencies in Ireland. Created in 1992, one of the hallmarks of this agency is its independence from other parts of government. Yet little is known about the actual extent of its independence. Independence and the Irish Environmental Protection Agency: A Comparative Assessment addresses several key questions about the agency's independence. Why was independence such a primary justification for the creation of this a...

  11. Comparative genomics of Geobacter chemotaxis genes reveals diverse signaling function

    Directory of Open Access Journals (Sweden)

    Antommattei Frances M

    2008-10-01

    Full Text Available Abstract Background Geobacter species are δ-Proteobacteria and are often the predominant species in a variety of sedimentary environments where Fe(III reduction is important. Their ability to remediate contaminated environments and produce electricity makes them attractive for further study. Cell motility, biofilm formation, and type IV pili all appear important for the growth of Geobacter in changing environments and for electricity production. Recent studies in other bacteria have demonstrated that signaling pathways homologous to the paradigm established for Escherichia coli chemotaxis can regulate type IV pili-dependent motility, the synthesis of flagella and type IV pili, the production of extracellular matrix material, and biofilm formation. The classification of these pathways by comparative genomics improves the ability to understand how Geobacter thrives in natural environments and better their use in microbial fuel cells. Results The genomes of G. sulfurreducens, G. metallireducens, and G. uraniireducens contain multiple (~70 homologs of chemotaxis genes arranged in several major clusters (six, seven, and seven, respectively. Unlike the single gene cluster of E. coli, the Geobacter clusters are not all located near the flagellar genes. The probable functions of some Geobacter clusters are assignable by homology to known pathways; others appear to be unique to the Geobacter sp. and contain genes of unknown function. We identified large numbers of methyl-accepting chemotaxis protein (MCP homologs that have diverse sensing domain architectures and generate a potential for sensing a great variety of environmental signals. We discuss mechanisms for class-specific segregation of the MCPs in the cell membrane, which serve to maintain pathway specificity and diminish crosstalk. Finally, the regulation of gene expression in Geobacter differs from E. coli. The sequences of predicted promoter elements suggest that the alternative sigma factors

  12. Information Uncertainty to Compare Qualitative Reasoning Security Risk Assessment Results

    Energy Technology Data Exchange (ETDEWEB)

    Chavez, Gregory M [Los Alamos National Laboratory; Key, Brian P [Los Alamos National Laboratory; Zerkle, David K [Los Alamos National Laboratory; Shevitz, Daniel W [Los Alamos National Laboratory

    2009-01-01

    The security risk associated with malevolent acts such as those of terrorism are often void of the historical data required for a traditional PRA. Most information available to conduct security risk assessments for these malevolent acts is obtained from subject matter experts as subjective judgements. Qualitative reasoning approaches such as approximate reasoning and evidential reasoning are useful for modeling the predicted risk from information provided by subject matter experts. Absent from these approaches is a consistent means to compare the security risk assessment results. Associated with each predicted risk reasoning result is a quantifiable amount of information uncertainty which can be measured and used to compare the results. This paper explores using entropy measures to quantify the information uncertainty associated with conflict and non-specificity in the predicted reasoning results. The measured quantities of conflict and non-specificity can ultimately be used to compare qualitative reasoning results which are important in triage studies and ultimately resource allocation. Straight forward extensions of previous entropy measures are presented here to quantify the non-specificity and conflict associated with security risk assessment results obtained from qualitative reasoning models.

  13. Comparative assessment of world research efforts on magnetic confinement fusion

    International Nuclear Information System (INIS)

    McKenney, B.L.; McGrain, M.; Rutherford, P.H.

    1990-02-01

    This report presents a comparative assessment of the world's four major research efforts on magnetic confinement fusion, including a comparison of the capabilities in the Soviet Union, the European Community (Western Europe), Japan, and the United States. A comparative evaluation is provided in six areas: tokamak confinement; alternate confinement approaches; plasma technology and engineering; and fusion computations. The panel members are involved actively in fusion-related research, and have extensive experience in previous assessments and reviews of the world's four major fusion programs. Although the world's four major fusion efforts are roughly comparable in overall capabilities, two conclusions of this report are inescapable. First, the Soviet fusion effort is presently the weakest of the four programs in most areas of the assessment. Second, if present trends continue, the United States, once unambiguously the world leader in fusion research, will soon lose its position of leadership to the West European and Japanese fusion programs. Indeed, before the middle 1990s, the upgraded large-tokamak facilities, JT-60U (Japan) and JET (Western Europe), are likely to explore plasma conditions and operating regimes well beyond the capabilities of the TFTR tokamak (United States). In addition, if present trends continue in the areas of fusion nuclear technology and materials, and plasma technology and materials, and plasma technology development, the capabilities of Japan and Western Europe in these areas (both with regard to test facilities and fusion-specific industrial capabilities) will surpass those of the United States by a substantial margin before the middle 1990s

  14. Functional Behavior Assessment in Schools: Current Status and Future Directions

    Science.gov (United States)

    Anderson, Cynthia M.; Rodriguez, Billie Jo; Campbell, Amy

    2015-01-01

    Functional behavior assessment is becoming a commonly used practice in school settings. Accompanying this growth has been an increase in research on functional behavior assessment. We reviewed the extant literature on documenting indirect and direct methods of functional behavior assessment in school settings. To discern best practice guidelines…

  15. Dual-source computed tomography. Effect on regional and global left ventricular function assessment compared to magnetic resonance imaging; Untersuchung der regionalen und globalen linksventrikulaeren Funktion mit der Dual-Source-Computertomografie im Vergleich zur Magnetresonanztomografie

    Energy Technology Data Exchange (ETDEWEB)

    Lueders, F.; Seifarth, H.; Wessling, J.; Heindel, W.; Juergens, Kai Uwe [Inst. fuer Klinische Radiologie, Universitaetsklinikum Muenster (Germany); Fischbach, R. [Klinik fuer Radiologie, Nuklearmedizin und Neuroradiologie, Asklepios Klinik Altona (Germany)

    2009-10-15

    Purpose: to determine regional and global left ventricular (LV) functional parameters and to perform segmental wall thickness (SWT) and motion (WM) analysis of dual source CT (DSCT) with optimized temporal resolution versus MRI. Materials and Methods: 30 patients with known or suspected CAD, non-obstructive HCM, DCM, ARVCM, Fallot Tetralogy, cardiac sarcoidosis and cardiac metastasis underwent DSCT and MRI. The DSCT and MR images were evaluated: end-systolic (ESV), end-diastolic LV (EDV) volumes, stroke volume (SV), ejection fraction (EF), and myocardial mass (MM) as well as LV wall thickening and segmental WM applying the AHA model were obtained and statistically analyzed. Results: The mean LV-EDV (r = 0.96) and ESV (r = 0.98) as well as LV-EF (r = 0.97), SV (r = 0.83), and MM (r = 0.95) correlated well. Bland Altman analysis revealed little systematic underestimation of LV-EF (-1.1 {+-} 7.8%), EDV (-0.3 {+-} 18.2 ml), SV (-1.3 {+-} 16.7 ml) and little overestimation of ESV (1.1 {+-} 7.8 ml) and MM (12.8 {+-} 14.4 g) determined by DSCT. Systolic reconstruction time points correlated well (DSCT 32.2 {+-} 6.7 vs. MRI 35.6 {+-} 4.4% RR-interval). The LV wall thickness obtained by DSCT and MRI showed close correlation in all segments (diameter diff 0.42 {+-} 1 mm). In 413 segments (89%) WM abnormalities were equally rated, whereas DSCT tended to underestimate the degree of wall motion impairment. Conclusion: DSCT with optimized temporal resolution enables regional and global LV function analysis as well as segmental WM analysis in good correlation with MRI. However, the degree of WM impairment is slightly underestimated by DSCT. (orig.)

  16. Mechanomyogram for muscle function assessment: a review.

    Directory of Open Access Journals (Sweden)

    Md Anamul Islam

    Full Text Available Mechanomyography (MMG has been extensively applied in clinical and experimental practice to examine muscle characteristics including muscle function (MF, prosthesis and/or switch control, signal processing, physiological exercise, and medical rehabilitation. Despite several existing MMG studies of MF, there has not yet been a review of these. This study aimed to determine the current status on the use of MMG in measuring the conditions of MFs.Five electronic databases were extensively searched for potentially eligible studies published between 2003 and 2012. Two authors independently assessed selected articles using an MS-Word based form created for this review. Several domains (name of muscle, study type, sensor type, subject's types, muscle contraction, measured parameters, frequency range, hardware and software, signal processing and statistical analysis, results, applications, authors' conclusions and recommendations for future work were extracted for further analysis. From a total of 2184 citations 119 were selected for full-text evaluation and 36 studies of MFs were identified. The systematic results find sufficient evidence that MMG may be used for assessing muscle fatigue, strength, and balance. This review also provides reason to believe that MMG may be used to examine muscle actions during movements and for monitoring muscle activities under various types of exercise paradigms.Overall judging from the increasing number of articles in recent years, this review reports sufficient evidence that MMG is increasingly being used in different aspects of MF. Thus, MMG may be applied as a useful tool to examine diverse conditions of muscle activity. However, the existing studies which examined MMG for MFs were confined to a small sample size of healthy population. Therefore, future work is needed to investigate MMG, in examining MFs between a sufficient number of healthy subjects and neuromuscular patients.

  17. Comparative assessment of nanomaterial definitions and safety evaluation considerations.

    Science.gov (United States)

    Boverhof, Darrell R; Bramante, Christina M; Butala, John H; Clancy, Shaun F; Lafranconi, Mark; West, Jay; Gordon, Steve C

    2015-10-01

    Nanomaterials continue to bring promising advances to science and technology. In concert have come calls for increased regulatory oversight to ensure their appropriate identification and evaluation, which has led to extensive discussions about nanomaterial definitions. Numerous nanomaterial definitions have been proposed by government, industry, and standards organizations. We conducted a comprehensive comparative assessment of existing nanomaterial definitions put forward by governments to highlight their similarities and differences. We found that the size limits used in different definitions were inconsistent, as were considerations of other elements, including agglomerates and aggregates, distributional thresholds, novel properties, and solubility. Other important differences included consideration of number size distributions versus weight distributions and natural versus intentionally-manufactured materials. Overall, the definitions we compared were not in alignment, which may lead to inconsistent identification and evaluation of nanomaterials and could have adverse impacts on commerce and public perceptions of nanotechnology. We recommend a set of considerations that future discussions of nanomaterial definitions should consider for describing materials and assessing their potential for health and environmental impacts using risk-based approaches within existing assessment frameworks. Our intent is to initiate a dialogue aimed at achieving greater clarity in identifying those nanomaterials that may require additional evaluation, not to propose a formal definition. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  18. Comparative mapping reveals similar linkage of functional genes to ...

    Indian Academy of Sciences (India)

    genes between O. sativa and B. napus may have consistent function and control similar traits, which may be ..... acea chromosomes reveals islands of conserved organization. ... 1998 Conserved structure and function of the Arabidopsis flow-.

  19. Comparative assessment of electricity generation options using DECADES

    International Nuclear Information System (INIS)

    Perez Martin, D.; Lopez Lopez, I.; Turtos Carbonell, L.

    1999-01-01

    Cuba is poor in primary energy resources. In 1998, 99.4% of electricity generated by the National Electric System came from fossil fuel with the environment implications that this Situation causes. Cuba joint DECADES project (Databases and methodologies for Comparative Assessment of Different Energy Sources) to support planning and decision making process with Appropriated tools. The paper presents the main work carried out with DECADES. An important Effort was devoted to implement the Country Specific Database, to assess power plants and Chains, to select and evaluate different expansion scenarios taking into consideration its Environment implications. At the same time an effort was dedicated to correct, test and Implement DECADES capabilities. The potential role of nuclear power in the expansion policy of Cuban electric system, the Influence of an Oil Steam Boiler project and control technology installation, were performed. Conclusions of the main task done with DECADES are presented

  20. Framework for a comparative environmental assessment of drilling fluids

    Energy Technology Data Exchange (ETDEWEB)

    Meinhold, A.F.

    1998-11-01

    During the drilling of an oil or gas well, drilling fluid (or mud) is used to maintain well control and to remove drill cuttings from the hole. In response to effluent limitation guidelines promulgated by the US Environmental Protection Agency (EPA) for discharge of drilling wastes offshore, alternatives to water and oil-based muds have been developed. These synthetic-based muds (SBMs) are more efficient than water-based muds (WBMs) for drilling difficult and complex formation intervals and have lower toxicity and smaller environmental impacts than diesel or conventional mineral oil-based muds (OBMs). A third category of drilling fluids, derived from petroleum and called enhanced mineral oils (EMOs), also have these advantages over the traditionally used OBMs and WBMs. EPA recognizes that SBMs and EMOs are new classes of drilling fluids, but their regulatory status is unclear. To address this uncertainty, EPA is following an innovative presumptive rulemaking process that will develop final regulations for SBM discharges offshore in less than three years. This report develops a framework for a comparative risk assessment for the discharge of SBMs and EMOs, to help support a risk-based, integrated approach to regulatory decision making. The framework will help identify potential impacts and benefits associated with the use of SBMs, EMOs, WBMs, and OBMs; identify areas where additional data are needed; and support early decision-making in the absence of complete data. As additional data becomes available, the framework can support a full quantitative comparative assessment. Detailed data are provided to support a comparative assessment in the areas of occupational and public health impacts.

  1. Individual differences and subjective workload assessment - Comparing pilots to nonpilots

    Science.gov (United States)

    Vidulich, Michael A.; Pandit, Parimal

    1987-01-01

    Results by two groups of subjects, pilots and nonpilots, for two subjective workload assessment techniques (the SWAT and NASA-TLX tests) intended to evaluate individual differences in the perception and reporting of subjective workload are compared with results obtained for several traditional personality tests. The personality tests were found to discriminate between the groups while the workload tests did not. It is concluded that although the workload tests may provide useful information with respect to the interaction between tasks and personality, they are not effective as pure tests of individual differences.

  2. Comparative Assessment of Severe Accidents in the Chinese Energy Sector

    Energy Technology Data Exchange (ETDEWEB)

    Hirschberg, S; Burgherr, P; Spiekerman, G; Cazzoli, E; Vitazek, J; Cheng, L

    2003-03-01

    This report deals with the comparative assessment of accidents risks characteristic for the various electricity supply options. A reasonably complete picture of the wide spectrum of health, environmental and economic effects associated with various energy systems can only be obtained by considering damages due to normal operation as well as due to accidents. The focus of the present work is on severe accidents, as these are considered controversial. By severe accidents we understand potential or actual accidents that represent a significant risk to people, property and the environment and may lead to large consequences. (author)

  3. Methods for comparative risk assessment of different energy sources

    International Nuclear Information System (INIS)

    1992-10-01

    The environmental and health aspects of different energy systems, particularly those associated with the generation of electricity, are emerging as significant issues for policy formulation and implementation. This, together with the growing need of many countries to define their energy programmes for the next century, has provided the basis for a renewed interest in the comparative risk assessment of different energy sources (fossil, nuclear, renewables). This document is the outcome of a Specialists Meeting on the procedural and methodological issues associated with comparative health and environmental risks of different energy sources. After an introductory chapter outlining the issues under consideration the papers presented at the Meeting, which have been indexed separately, are given. Refs, figs and tabs

  4. Comparative analysis of deterministic and probabilistic fracture mechanical assessment tools

    Energy Technology Data Exchange (ETDEWEB)

    Heckmann, Klaus [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) gGmbH, Koeln (Germany); Saifi, Qais [VTT Technical Research Centre of Finland, Espoo (Finland)

    2016-11-15

    Uncertainties in material properties, manufacturing processes, loading conditions and damage mechanisms complicate the quantification of structural reliability. Probabilistic structure mechanical computing codes serve as tools for assessing leak- and break probabilities of nuclear piping components. Probabilistic fracture mechanical tools were compared in different benchmark activities, usually revealing minor, but systematic discrepancies between results of different codes. In this joint paper, probabilistic fracture mechanical codes are compared. Crack initiation, crack growth and the influence of in-service inspections are analyzed. Example cases for stress corrosion cracking and fatigue in LWR conditions are analyzed. The evolution of annual failure probabilities during simulated operation time is investigated, in order to identify the reasons for differences in the results of different codes. The comparison of the tools is used for further improvements of the codes applied by the partners.

  5. Assessing Executive Functioning: A Pragmatic Review

    Science.gov (United States)

    Hass, Michael R.; Patterson, Ashlea; Sukraw, Jocelyn; Sullivan, Brianna M.

    2014-01-01

    Despite the common usage of the term "executive functioning" in neuropsychology, several aspects of this concept remain unsettled. In this paper, we will address some of the issues surrounding the notion of executive functioning and how an understanding of executive functioning and its components might assist school-based practitioners…

  6. Functional outcome of microsurgical clipping compared to endovascular coiling.

    Science.gov (United States)

    Premananda, R M; Ramesh, N; Hillol, K P

    2012-12-01

    Endovascular coiling has been used increasingly as an alternative to neurosurgical clipping for treating subarachnoid hemorrhage secondary to aneurysm rupture. In a retrospective cohort review on the treatment methods of aneurysm rupture in Hospital Kuala Lumpur over the period of five years (2005-2009) a total of 268 patients were treated. These patients were broadly categorized into two groups based on their treatment mode for ruptured aneurysms. Statistical analysis was determined using Chi- Square tests to study these associations. In our study, 67.5% of patients presented with Good World Federation of Neurosurgical Societies (WFNS) grade (WFNS1-2) while 32.5% patients presented with Poor WFNS prior to intervention. In our outcome, it was noted that 60.4% had good functional outcome (mRS grade 0-2) as compared to 39.6% patients who had poor mRS(modified rankin scale) outcome (mRS 3-6). In the good WFNS group, 76% of patients in clipping group had a good mRS outcome while, 86.5% patients in coiling group had good mRS outcome (p=0.114). In poor WFNS presentation, it was noted that in 77.3% patients in clipping group, had poor mRS outcome. Similarly with poor WFNS presentation, 83.3% of patient in coiling group had poor outcome. (p=1.00). Hence when we control the WFNS group, there was no significant association between treatment group (clipping and coiling) and mRS outcome at 6 months. The outcome of patient is determined by initial clinical presentation (WFNS grade) and influenced by requirement of Extraventricular drain (EVD) in presence of hydrocephalus, CSF infection and pneumonia. Therefore the decision regarding treatment option needs to be individualized based on the presentation of the patient.

  7. Comparative assessment of severe accident risks in the energy sector

    International Nuclear Information System (INIS)

    Hirschberg, S.; Spiekerman, G.; Dones, R.

    1997-01-01

    This paper addresses one of the major limitations of the current comparative studies of environmental and health impacts of energy systems, i.e. the treatment of severe accidents. The work covers technical aspects of severe accidents and thus primarily reflects an engineering perspective on the energy-related risk issues. The assessments concern full energy chains associated with fossil sources (coal, oil and gas), nuclear power and hydro power. A comprehensive severe accidents database has been established. Thanks to the variety of information sources used, it exhibits in comparison with other corresponding databases a far more extensive coverage of the energy-related accidents. For hypothetical nuclear accidents the probabilistic approach has been employed and extended to cover the economic consequences of power reactor accidents. Results of comparisons between the various energy chains are shown and discussed along with a number of current issues in comparative assessment of severe accidents. As opposed to the previous studies, the aim of the present work has been, to cover whenever possible, a relatively broad spectrum of damage categories of interest. (author) 5 figs., 1 tab., 18 refs

  8. Comparative study on spreading function for directional wave spectra

    Digital Repository Service at National Institute of Oceanography (India)

    Bhat, S.S.; Anand, N.M.; Nayak, B.U.

    -dimensional wave energy S(f) and the directional spreading function D(f, theta). This paper reviews various spreading functions proposed in the past for estimating the directional wave energy and presents their application to the Indian wave condition. It is found...

  9. Physical Activity Level and Physical Functionality in Nonagenarians Compared to Individuals Aged 60–74 Years

    Science.gov (United States)

    Frisard, Madlyn I.; Fabre, Jennifer M.; Russell, Ryan D.; King, Christina M.; DeLany, James P.; Wood, Robert H.; Ravussin, Eric

    2009-01-01

    Background Functional dependence and the risks of disability increase with age. The loss of independence is thought to be partially due to a decrease in physical activity. However, in populations, accurate measurement of physical activity is challenging and may not provide information on functional impairment. Methods This study therefore assessed physical functionality and physical activity level in a group of nonagenarians (11 men/11 women; 93 ± 1 years, 66.6 ± 2.4 kg, body mass index [BMI] = 24 ± 1 kg/m2) and a group of participants aged 60–74 years (17 men/15 women; 70 ± 1 years, 83.3 ± 3.0 kg, BMI = 29 ± 1 kg/m2) from the Louisiana Healthy Aging Study. Physical activity level was calculated from total energy expenditure (TEE) and resting metabolic rate (RMR). Physical functionality was assessed using the Reduced Continuous Scale Physical Functional Performance Test (CS-PFP10). Results Nonagenarians had lower absolute ( p < .001) and adjusted ( p < .007) TEE compared to participants aged 60–74 years which was attributed to a reduction in both RMR and physical activity level. Nonagenarians also had reduced functional performance ( p < .001) which was correlated with activity level (r = 0.68, p < .001). Conclusions When compared to individuals aged 60–74 years, 73% of the reduction in TEE in nonagenarians can be attributed to a reduction in physical activity level, the remaining being accounted for by a reduction in RMR. The reduced physical activity in nonagenarians is associated with less physical functionality. This study provides the first objective comparison of physical functionality and actual levels of physical activity in older individuals. PMID:17634327

  10. A Comparison of Experimental Functional Analysis and the Questions about Behavioral Function (QABF) in the Assessment of Challenging Behavior of Individuals with Autism

    Science.gov (United States)

    Healy, Olive; Brett, Denise; Leader, Geraldine

    2013-01-01

    We compared two functional behavioral assessment methods: the Questions About Behavioral Function (QABF; a standardized test) and experimental functional analysis (EFA) to identify behavioral functions of aggressive/destructive behavior, self-injurious behavior and stereotypy in 32 people diagnosed with autism. Both assessments found that self…

  11. Comparative study of probabilistic methodologies for small signal stability assessment

    Energy Technology Data Exchange (ETDEWEB)

    Rueda, J.L.; Colome, D.G. [Universidad Nacional de San Juan (IEE-UNSJ), San Juan (Argentina). Inst. de Energia Electrica], Emails: joseluisrt@iee.unsj.edu.ar, colome@iee.unsj.edu.ar

    2009-07-01

    Traditional deterministic approaches for small signal stability assessment (SSSA) are unable to properly reflect the existing uncertainties in real power systems. Hence, the probabilistic analysis of small signal stability (SSS) is attracting more attention by power system engineers. This paper discusses and compares two probabilistic methodologies for SSSA, which are based on the two point estimation method and the so-called Monte Carlo method, respectively. The comparisons are based on the results obtained for several power systems of different sizes and with different SSS performance. It is demonstrated that although with an analytical approach the amount of computation of probabilistic SSSA can be reduced, the different degrees of approximations that are adopted, lead to deceptive results. Conversely, Monte Carlo based probabilistic SSSA can be carried out with reasonable computational effort while holding satisfactory estimation precision. (author)

  12. Expanding the power base. Building capacities for comparative energy assessment

    International Nuclear Information System (INIS)

    Hamilton, B.; Bui, D.T.; Conzelmann, G.

    2000-01-01

    Analysis of national energy systems is reaching unprecedented degrees of complexity. In addition to uncertainty of future energy demand, technology performance and costs, planners and decision makers are confronted with issues such as environment protection, sustainable development, deregulation and market liberalization. At the same time, public sector funds for energy investment projects are being progressively reduced. The IAEA offers its Member States a comprehensive programme of technical assistance and cooperation which covers many diverse areas related to peaceful uses of nuclear energy. In the area of comparative energy assessment, the objective of assistance is to strengthen national capabilities for elaborating sustainable patterns of energy supply and use. Assistance is provided in three ways, namely by: distributing state-of-the-art methodologies and decision-making tools tailored to the special needs of developing countries; providing training in model application, interpretation of results and translation into decision or policy making; and carrying out national studies in co-operation with requesting Member States

  13. Collaborative framework for PIV uncertainty quantification: comparative assessment of methods

    International Nuclear Information System (INIS)

    Sciacchitano, Andrea; Scarano, Fulvio; Neal, Douglas R; Smith, Barton L; Warner, Scott O; Vlachos, Pavlos P; Wieneke, Bernhard

    2015-01-01

    A posteriori uncertainty quantification of particle image velocimetry (PIV) data is essential to obtain accurate estimates of the uncertainty associated with a given experiment. This is particularly relevant when measurements are used to validate computational models or in design and decision processes. In spite of the importance of the subject, the first PIV uncertainty quantification (PIV-UQ) methods have been developed only in the last three years. The present work is a comparative assessment of four approaches recently proposed in the literature: the uncertainty surface method (Timmins et al 2012), the particle disparity approach (Sciacchitano et al 2013), the peak ratio criterion (Charonko and Vlachos 2013) and the correlation statistics method (Wieneke 2015). The analysis is based upon experiments conducted for this specific purpose, where several measurement techniques are employed simultaneously. The performances of the above approaches are surveyed across different measurement conditions and flow regimes. (paper)

  14. A Study To Evaluate the Effectiveness of the Montana Functional Vision Assessment for Multihandicapped Persons.

    Science.gov (United States)

    Marks, Ron

    The study evaluated the validity, reliability, and effectiveness in providing needed information of the Montana Functional Vision Assessment (MFVA) Instrument by comparing it with the Texas Education Agency Functional Vision Assessment and field testing the instrument in evaluations of nine multihandicapped students (ages 3-11). Evaluation led to…

  15. Comparative Assessment of Stabilised Polybutadiene Binder under Accelerated Ageing

    Directory of Open Access Journals (Sweden)

    Luiz Felipe Cannaval Sbegue

    2016-04-01

    Full Text Available Polybutadiene elastomers are versatile materials, being employed at several applications from rocket propellant binder to adhesives and sealants. The elastomers derived from hydroxyl-terminated polybutadiene are usually stabilised with antioxidants to prevent degradation. In this study, a comparative assessment among 2,2’-methylene-bis (4-methyl-6-tert-butylphenol (AO2246, 2,6-di-tert-butyl-4-methylphenol (BHT, p-phenylenediamine (pPDA, and triphenylphosphine (TPP regarding stabilisation of hydroxyl-terminated polybutadiene binder under accelerated ageing (six months at 65 °C was carried out. Evaluation of antioxidants effectiveness was examined through Oxidation Induction time, sol/gel extraction, swelling and mechanical testing, dynamic mechanical analysis, and mass variation measurement. AO2246 yielded the best performance, meanwhile BHT was poorly protective. TPP acted as prooxidant, causing a severe degradation of the binder, and pPDA was not manageable to be assessed due to the lower curing degree of the resulted polyurethane.

  16. A comparative assessment of the economics of plutonium disposition

    International Nuclear Information System (INIS)

    Williams, K.A.; Miller, J.W.; Reid, R.L.

    1997-01-01

    The US Department of Energy office of Fissile Materials Disposition (DOE/MD) has been evaluating three technologies for the disposition of approximately 50 metric tons of surplus plutonium from defense-related programs: reactors, immobilization, and deep boreholes. As part of the process supporting an early CY 1997 Record of Decision (ROD), a comprehensive assessment of technical viability, cost, and schedule has been conducted by DOE/MD and its national laboratory contractors. Oak Ridge National Laboratory has managed and coordinated the life-cycle cost (LCC) assessment effort for this program. This paper discusses the economic analysis methodology and the results prior to ROD. A secondary intent of the paper is to discuss major technical and economic issues that impact cost and schedule. To evaluate the economics of these technologies on an equitable basis, a set of cost-estimating guidelines and a common cost-estimating format were utilized by all three technology teams. This paper also includes the major economic analysis assumptions and the comparative constant-dollar and discounted-dollar LCCs

  17. Assessing functional impairment in siblings living with children with disability.

    Science.gov (United States)

    Goudie, Anthony; Havercamp, Susan; Jamieson, Barry; Sahr, Timothy

    2013-08-01

    The purpose of this study was to empirically test if siblings of children with disability had higher levels of parent-reported behavioral and emotional functional impairment compared with a peer group of siblings residing with only typically developing children. This was a retrospective secondary analysis of data from the Medical Expenditure Panel Survey. We included only households with at least 2 children to ensure sibling relationships. Two groups of siblings were formed: 245 siblings resided in households with a child with disability and 6564 siblings resided in households with typically developing children. Parents responded to questions from the Columbia Impairment Scale to identify functional impairment in their children. On the basis of parent reports and after adjusting for sibling demographic characteristics and household background, siblings of children with disability were more likely than siblings residing with typically developing children to have problems with interpersonal relationships, psychopathological functioning, functioning at school, and use of leisure time (P siblings of children with disability classified with significant functional impairment was 16.0% at the first measurement period and 24.2% at the second (P siblings of typically developing children there was a smaller percentage increase from 9.5% to 10.3% (P mental health services and, as such, early assessment and interventions to limit increasing severity and short- to long-term consequences need to be addressed. Health care professionals need to consider a family-based health care approach for families raising children with disability.

  18. Social Dynamics Management and Functional Behavioral Assessment

    Science.gov (United States)

    Lee, David L.

    2018-01-01

    Managing social dynamics is a critical aspect of creating a positive learning environment in classrooms. In this paper three key interrelated ideas, reinforcement, function, and motivating operations, are discussed with relation to managing social behavior.

  19. Functional-Based Assessment of Social Behavior: Introduction and Overview.

    Science.gov (United States)

    Lewis, Timothy J.; Sugai, George

    1994-01-01

    This introduction to and overview of a special issue on social behavior assessment within schools discusses the impact of function-based methodologies on assessment and intervention practices in identification and remediation of challenging social behaviors. (JDD)

  20. Comparative assessment of condensation models for horizontal tubes

    International Nuclear Information System (INIS)

    Schaffrath, A.; Kruessenberg, A.K.; Lischke, W.; Gocht, U.; Fjodorow, A.

    1999-01-01

    The condensation in horizontal tubes plays an important role e.g. for the determination of the operation mode of horizontal steam generators of VVER reactors or passive safety systems for the next generation of nuclear power plants. Two different approaches (HOTKON and KONWAR) for modeling this process have been undertaken by Forschungszentrum Juelich (FZJ) and University for Applied Sciences Zittau/Goerlitz (HTWS) and implemented into the 1D-thermohydraulic code ATHLET, which is developed by the Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH for the analysis of anticipated and abnormal transients in light water reactors. Although the improvements of the condensation models are developed for different applications (VVER steam generators - emergency condenser of the SWR1000) with strongly different operation conditions (e.g. the temperature difference over the tube wall in HORUS is up to 30 K and in NOKO up to 250 K, the heat flux density in HORUS is up to 40 kW/m 2 and in NOKO up to 1 GW/m 2 ) both models are now compared and assessed by Forschungszentrum Rossendorf FZR e.V. Therefore, post test calculations of selected HORUS experiments were performed with ATHLET/KONWAR and compared to existing ATHLET and ATHLET/HOTKON calculations of HTWS. It can be seen that the calculations with the extension KONWAR as well as HOTKON improve significantly the agreement between computational and experimental data. (orig.) [de

  1. Comparative life cycle assessment of pistachio, almond and apple production

    Directory of Open Access Journals (Sweden)

    G. Bartzas

    2017-09-01

    Full Text Available A comparative life cycle assessment (LCA, with the use of GaBi 6 software and specific related databases, of three water intensive tree cultivation systems was conducted in order to evaluate environmental impacts and energy consumption. The tree crops are traditionally cultivated in two representative areas in Greece, namely Aegina island, Attica region, for pistachios and Agia, East Thessaly region, central Greece, for apples and almonds. The impact categories considered include global warming potential (GWP, eutrophication potential (EP, acidification potential (AP and cumulative energy demand (CED. Based upon the results obtained, it is deduced that pistachios and almonds show minor differences for all impact categories considered, while apples exhibit the best environmental profile. The phases of fertilizers production, irrigation system and field management were identified as the main “hot-spots” for all crops, exhibiting the highest environmental impacts and energy consumption. A sensitivity analysis was performed to explore actions that can be considered at farm scale, such as water desalination for irrigation purposes, transition to organic production and use of renewable energy, in order to reduce water requirements and promote energy conservation, especially in semi-arid and arid Mediterranean regions which suffer from water shortage and are prone to salinization. Finally, the results of this study were compared with the results derived from other relevant LCA studies.

  2. Comparative Assessment of Nonlocal Continuum Solvent Models Exhibiting Overscreening

    Directory of Open Access Journals (Sweden)

    Ren Baihua

    2017-01-01

    Full Text Available Nonlocal continua have been proposed to offer a more realistic model for the electrostatic response of solutions such as the electrolyte solvents prominent in biology and electrochemistry. In this work, we review three nonlocal models based on the Landau-Ginzburg framework which have been proposed but not directly compared previously, due to different expressions of the nonlocal constitutive relationship. To understand the relationships between these models and the underlying physical insights from which they are derive, we situate these models into a single, unified Landau-Ginzburg framework. One of the models offers the capacity to interpret how temperature changes affect dielectric response, and we note that the variations with temperature are qualitatively reasonable even though predictions at ambient temperatures are not quantitatively in agreement with experiment. Two of these models correctly reproduce overscreening (oscillations between positive and negative polarization charge densities, and we observe small differences between them when we simulate the potential between parallel plates held at constant potential. These computations require reformulating the two models as coupled systems of local partial differential equations (PDEs, and we use spectral methods to discretize both problems. We propose further assessments to discriminate between the models, particularly in regards to establishing boundary conditions and comparing to explicit-solvent molecular dynamics simulations.

  3. Comparative life cycle assessment of biodiesel and fossil diesel fuel

    International Nuclear Information System (INIS)

    Ceuterick, D.; Nocker, L. De; Spirinckx, C.

    1999-01-01

    Biofuels offer clear advantages in terms of greenhouse gas emissions, but do they perform better when we look at all the environmental impacts from a life cycle perspective. In the context of a demonstration project at the Flemish Institute for Technology Research (VITO) on the use of rapeseed methyl ester (RME) or biodiesel as automotive fuel, a life cycle assessment (LCA) of biodiesel and diesel was made. The primary concern was the question as to whether or not the biodiesel chain was comparable to the conventional diesel chain, from an environmental point of view, taking into account all stages of the life cycle of the two products. Additionally, environmental damage costs were calculated, using an impact pathway analysis. This paper presents the results of the two methods for evaluation of environmental impacts of RME and conventional diesel. Both methods are complementary and share the conclusion that although biodiesel has much lower greenhouse gas emissions, it still has significant impacts on other impact categories. The external costs of biodiesel are a bit lower compared to fossil diesel. For both fuels, external costs are significantly higher than the private production cost. (Author)

  4. A comparative life cycle assessment of marine power systems

    International Nuclear Information System (INIS)

    Ling-Chin, Janie; Roskilly, Anthony P.

    2016-01-01

    Highlights: • Correlation among resources, emissions, key components and processes was attained. • Environmental benefits of innovative power systems were verified. • New-build system showed a great advantage over retrofit and conventional systems. • Relative contribution of significant components remained or became more profound. • Influence of fuel consumption quantity over the estimates varied with impact types. - Abstract: Despite growing interest in advanced marine power systems, knowledge gaps existed as it was uncertain which configuration would be more environmentally friendly. Using a conventional system as a reference, the comparative life cycle assessment (LCA) study aimed to compare and verify the environmental benefits of advanced marine power systems i.e. retrofit and new-build systems which incorporated emerging technologies. To estimate the environmental impact attributable to each system, a bottom-up integrated system approach was applied, i.e. LCA models were developed for individual components using GaBi, optimised operational profiles and input data standardised from various sources. The LCA models were assessed using CML2001, ILCD and Eco-Indicator99 methodologies. The estimates for the advanced systems were compared to those of the reference system. The inventory analysis results showed that both retrofit and new-build systems consumed less fuels (8.28% and 29.7% respectively) and released less emissions (5.2–16.6% and 29.7–55.5% respectively) during operation whilst more resources were consumed during manufacture, dismantling and the end of life. For 14 impact categories relevant to global warming, acidification, eutrophication, photochemical ozone creation and PM/respiratory inorganic health issues, reduction in LCIA results was achieved by retrofit (2.7–6.6%) and new-build systems (35.7–50.7%). The LCIA results of the retrofit system increased in ecotoxicity (1–8%), resource depletion (1–2%) and fossil fuel depletion

  5. Making environmental assessments of biomass production systems comparable worldwide

    International Nuclear Information System (INIS)

    Meyer, Markus A; Seppelt, Ralf; Priess, Joerg A; Witing, Felix

    2016-01-01

    Global demand for agricultural and forestry products fundamentally affects regional land-use change associated with environmental impacts (EIs) such as erosion. In contrast to aggregated global metrics such as greenhouse gas (GHG) balances, local/regional EIs of different agricultural and forestry production regions need methods which enable worldwide EI comparisons. The key aspect is to control environmental heterogeneity to reveal man-made differences of EIs between production regions. Environmental heterogeneity is the variation in biotic and abiotic environmental conditions. In the present study, we used three approaches to control environmental heterogeneity: (i) environmental stratification, (ii) potential natural vegetation (PNV), and (iii) regional environmental thresholds to compare EIs of solid biomass production. We compared production regions of managed forests and plantation forests in subtropical (Satilla watershed, Southeastern US), tropical (Rufiji basin, Tanzania), and temperate (Mulde watershed, Central Germany) climates. All approaches supported the comparison of the EIs of different land-use classes between and within production regions. They also standardized the different EIs for a comparison between the EI categories. The EIs for different land-use classes within a production region decreased with increasing degree of naturalness (forest, plantation forestry, and cropland). PNV was the most reliable approach, but lacked feasibility and relevance. The PNV approach explicitly included most of the factors that drive environmental heterogeneity in contrast to the stratification and threshold approaches. The stratification approach allows consistent global application due to available data. Regional environmental thresholds only included arbitrarily selected aspects of environmental heterogeneity; they are only available for few EIs. Especially, the PNV and stratification approaches are options to compare regional EIs of biomass or crop production

  6. Clinical assessment tools identify functional deficits in fragility fracture patients

    Directory of Open Access Journals (Sweden)

    Ames TD

    2016-05-01

    Full Text Available Tyler D Ames,1 Corinne E Wee,1 Khoi M Le,1 Tiffany L Wang,1 Julie Y Bishop,2 Laura S Phieffer,2 Carmen E Quatman2 1The Ohio State University College of Medicine, 2Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA Purpose: To identify inexpensive, noninvasive, portable, clinical assessment tools that can be used to assess functional performance measures that may put older patients at risk for falls such as balance, handgrip strength, and lumbopelvic control.Patients and methods: Twenty fragility fracture patients and 21 healthy control subjects were evaluated using clinical assessment tools (Nintendo Wii Balance Board [WBB], a handheld dynamometer, and an application for the Apple iPod Touch, the Level Belt that measure functional performance during activity of daily living tasks. The main outcome measurements were balance (WBB, handgrip strength (handheld dynamometer, and lumbopelvic control (iPod Touch Level Belt, which were compared between fragility fracture patients and healthy controls.Results: Fragility fracture patients had lower scores on the vertical component of the WBB Torso Twist task (P=0.042 and greater medial–lateral lumbopelvic sway during a 40 m walk (P=0.026 when compared to healthy controls. Unexpectedly, the fracture patients had significantly higher scores on the left leg (P=0.020 and total components (P=0.010 of the WBB Single Leg Stand task as well as less faults during the left Single Leg Stand task (P=0.003.Conclusion: The clinical assessment tools utilized in this study are relatively inexpensive and portable tools of performance measures capable of detecting differences in postural sway between fragility fracture patients and controls. Keywords: fall risk, geriatric fracture, Nintendo Wii Balance Board, Level Belt, fragility fracture

  7. Comparative evaluation of maintenance performance using subsurvival functions

    DEFF Research Database (Denmark)

    Paulsen, J.L.; Cooke, R.; Nyman, R.

    1997-01-01

    Subsurvival functions are applied to operational data for the control rod drive systems of Nordic nuclear reactors to evaluate maintenance performance. Competing failure modes are preventive and corrective maintenance. Maintenance indicators are defined and evaluated for 8 plants. (C) 1997 Elsevier...

  8. MRI to assess renal structure and function.

    Science.gov (United States)

    Artunc, Ferruh; Rossi, Cristina; Boss, Andreas

    2011-11-01

    In addition to excellent anatomical depiction, MRI techniques have expanded to study functional aspects of renal physiology, such as renal perfusion, glomerular filtration rate (GFR) or tissue oxygenation. This review will focus on current developments with an emphasis on clinical applicability. The method of GFR determination is largely heterogeneous and still has weaknesses. However, the technique of employing liver disappearance curves has been shown to be accurate in healthy persons and patients with chronic kidney disease. In potential kidney donors, complete evaluation of kidney anatomy and function can be accomplished in a single-stop investigation. Techniques without contrast media can be utilized to measure renal tissue oxygenation (blood oxygen level-dependent MRI) or perfusion (arterial spin labeling) and could aid in the diagnosis and treatment of ischemic renal diseases, such as renal artery stenosis. Diffusion imaging techniques may provide information on spatially restricted water diffusion and tumor cellularity. Functional MRI opens new horizons in studying renal physiology and pathophysiology in vivo. Although extensively utilized in research, labor-intensive postprocessing and lack of standardization currently limit the clinical applicability of functional MRI. Further studies are necessary to evaluate the clinical value of functional magnetic resonance techniques for early discovery and characterization of kidney disease.

  9. Psychiatric Comorbidity and Functioning in a Clinically Referred Population of Adults with Autism Spectrum Disorders: A Comparative Study

    Science.gov (United States)

    Joshi, Gagan; Wozniak, Janet; Petty, Carter; Martelon, Mary Kate; Fried, Ronna; Bolfek, Anela; Kotte, Amelia; Stevens, Jonathan; Furtak, Stephannie L.; Bourgeois, Michelle; Caruso, Janet; Caron, Ashley; Biederman, Joseph

    2013-01-01

    To systematically examine the patterns of psychiatric comorbidity and functioning in clinically referred adults with autism spectrum disorders (ASD). Psychiatrically referred adults with and without ASD were compared on measures assessing for psychiatric comorbidity and psychosocial functioning. Sixty-three adults with ASD participated in the…

  10. A field study comparing two methods of transportation risk assessment

    International Nuclear Information System (INIS)

    Harmon, M.F.; Brey, R.R.; Gesell, T.F.; Oberg, S.G.

    1996-01-01

    RADTRAN 4 is a computer code used for; assessing risks associated with the transportation of nuclear materials. The code employs the common modeling practice of using default values for input variables to simplify the modeling of complex scenarios, thus producing conservative final risk determinations. To better address local public concerns it is of interest to quantify the introduced conservatism by taking a site-specific approach to radiation risk assessment. With RISKIND, incident-free and accident condition doses were calculated for two suburban population groups using both default input parameters; and site-specific values to describe population demographics of regions in Pocatello, Idaho, along the I-15 corridor. The use of site-specific parameters resulted in incident-free doses ranging from the same order of magnitude to one order of magnitude less than the doses calculated with default input parameters. Correcting accident condition doses for the age distribution of the populations and employing site-specific weather data resulted in doses 1.1 times lower than estimated using default input parameters. Dose-risks calculated with RISKIND for the two population groups using site-specific data were of the same order of magnitude as the risk calculated using RADTRAN 4 for the suburban population described in DOE/EIS-0203-D. This study revealed in one specific application that use of default and site-specific parameters resulted in comparable dose estimates. If this tendency were to hold generally true over other environments and model variables, then risk assessors might prefer to select codes on the basis of criteria such as (1) the number of variables to select from; (2) ability to calculate consequences directly, and (3) outputs geared to addressing public concerns

  11. Policy priority objectives: comparative assessment in four European cities

    Energy Technology Data Exchange (ETDEWEB)

    Alonso Ramos, A.

    2016-07-01

    Sustainability must be an urban issue. Cities should be managed so as to minimize their impacts on environment, but providing an appropriate framework for economic and social development. However, European cities are facing some trends that threaten sustainable development. The aim of the EC research project INSIGHT-7FP (2013/16) is to develop appropriate management tools that can help to achieve sustainability in the context of European cities. In the project, a set of policy objectives have been designed for the management of urban areas, in order to face the main threats existing over cities. The paper presents a methodology based on indicators for analysing the progress towards these ten policy objectives in the four EU cities participating in the project: London (12.3 mill. inhab.), Madrid (6.4 mill. inhab.), Barcelona (5.4 mill. inhab.) and Rotterdam (1.4 mill. inhab.). All the indicators used in the analysis have been validated by ten policy makers of European cities. These policy makers participated on the stakeholders consultation carried out in the project, where the importance of the policy objectives proposed was also assessed. The paper concludes determining the policy priority objectives in each city, in order to contain the main threats existing over them: London should especially address the threats of social exclusion and transport inefficiency; Madrid the threats of economic decline and urban sprawl; Barcelona the economic decline and Rotterdam the contribution to climate change and the urban sprawl. Finally, the role played by the land use and transport system in these policy objectives is analysed. To this end, the assessment allows for the comparability of the results in a horizontal manner, in the basis of common indicators. Nearly half of these indicators are related to the land use and transport system of the cities. (Author)

  12. Comparative environmental assessment of natural and recycled aggregate concrete.

    Science.gov (United States)

    Marinković, S; Radonjanin, V; Malešev, M; Ignjatović, I

    2010-11-01

    Constant and rapid increase in construction and demolition (C&D) waste generation and consumption of natural aggregate for concrete production became one of the biggest environmental problems in the construction industry. Recycling of C&D waste represents one way to convert a waste product into a resource but the environment benefits through energy consumption, emissions and fallouts reductions are not certain. The main purpose of this study is to determine the potentials of recycled aggregate concrete (concrete made with recycled concrete aggregate) for structural applications and to compare the environmental impact of the production of two types of ready-mixed concrete: natural aggregate concrete (NAC) made entirely with river aggregate and recycled aggregate concrete (RAC) made with natural fine and recycled coarse aggregate. Based on the analysis of up-to-date experimental evidence, including own tests results, it is concluded that utilization of RAC for low-to-middle strength structural concrete and non-aggressive exposure conditions is technically feasible. The Life Cycle Assessment (LCA) is performed for raw material extraction and material production part of the concrete life cycle including transport. Assessment is based on local LCI data and on typical conditions in Serbia. Results of this specific case study show that impacts of aggregate and cement production phases are slightly larger for RAC than for NAC but the total environmental impacts depend on the natural and recycled aggregates transport distances and on transport types. Limit natural aggregate transport distances above which the environmental impacts of RAC can be equal or even lower than the impacts of NAC are calculated for the specific case study. Copyright © 2010 Elsevier Ltd. All rights reserved.

  13. COMPARATIVE ASSESSMENT OF VERY HIGH RESOLUTION SATELLITE AND AERIAL ORTHOIMAGERY

    Directory of Open Access Journals (Sweden)

    P. Agrafiotis

    2015-03-01

    Full Text Available This paper aims to assess the accuracy and radiometric quality of orthorectified high resolution satellite imagery from Pleiades-1B satellites through a comparative evaluation of their quantitative and qualitative properties. A Pleiades-B1 stereopair of high resolution images taken in 2013, two adjacent GeoEye-1 stereopairs from 2011 and aerial orthomosaic (LSO provided by NCMA S.A (Hellenic Cadastre from 2007 have been used for the comparison tests. As control dataset orthomosaic from aerial imagery provided also by NCMA S.A (0.25m GSD from 2012 was selected. The process for DSM and orthoimage production was performed using commercial digital photogrammetric workstations. The two resulting orthoimages and the aerial orthomosaic (LSO were relatively and absolutely evaluated for their quantitative and qualitative properties. Test measurements were performed using the same check points in order to establish their accuracy both as far as the single point coordinates as well as their distances are concerned. Check points were distributed according to JRC Guidelines for Best Practice and Quality Checking of Ortho Imagery and NSSDA standards while areas with different terrain relief and land cover were also included. The tests performed were based also on JRC and NSSDA accuracy standards. Finally, tests were carried out in order to assess the radiometric quality of the orthoimagery. The results are presented with a statistical analysis and they are evaluated in order to present the merits and demerits of the imaging sensors involved for orthoimage production. The results also serve for a critical approach for the usability and cost efficiency of satellite imagery for the production of Large Scale Orthophotos.

  14. Phylogenetic comparative methods complement discriminant function analysis in ecomorphology.

    Science.gov (United States)

    Barr, W Andrew; Scott, Robert S

    2014-04-01

    In ecomorphology, Discriminant Function Analysis (DFA) has been used as evidence for the presence of functional links between morphometric variables and ecological categories. Here we conduct simulations of characters containing phylogenetic signal to explore the performance of DFA under a variety of conditions. Characters were simulated using a phylogeny of extant antelope species from known habitats. Characters were modeled with no biomechanical relationship to the habitat category; the only sources of variation were body mass, phylogenetic signal, or random "noise." DFA on the discriminability of habitat categories was performed using subsets of the simulated characters, and Phylogenetic Generalized Least Squares (PGLS) was performed for each character. Analyses were repeated with randomized habitat assignments. When simulated characters lacked phylogenetic signal and/or habitat assignments were random, ecomorphology. Copyright © 2013 Wiley Periodicals, Inc.

  15. Comparative risk assessment of severe accidents in the energy sector

    International Nuclear Information System (INIS)

    Burgherr, Peter; Hirschberg, Stefan

    2014-01-01

    Comparative assessment of accident risks in the energy sector is a key aspect in a comprehensive evaluation of sustainability and energy security concerns. Safety performance of energy systems can have important implications on the environmental, economic and social dimensions of sustainability as well as availability, acceptability and accessibility aspects of energy security. Therefore, this study provides a broad comparison of energy technologies based on the objective expression of accident risks for complete energy chains. For fossil chains and hydropower the extensive historical experience available in PSI's Energy-related Severe Accident Database (ENSAD) is used, whereas for nuclear a simplified probabilistic safety assessment (PSA) is applied, and evaluations of new renewables are based on a combination of available data, modeling, and expert judgment. Generally, OECD and EU 27 countries perform better than non-OECD. Fatality rates are lowest for Western hydropower and nuclear as well as for new renewables. In contrast, maximum consequences can be by far highest for nuclear and hydro, intermediate for fossil, and very small for new renewables, which are less prone to severe accidents. Centralized, low-carbon technology options could generally contribute to achieve large reductions in CO 2 -emissions; however, the principal challenge for both fossil with Carbon Capture and Storage and nuclear is public acceptance. Although, external costs of severe accidents are significantly smaller than those caused by air pollution, accidents can have disastrous and long-term impacts. Overall, no technology performs best or worst in all respects, thus tradeoffs and priorities are needed to balance the conflicting objectives such as energy security, sustainability and risk aversion to support rationale decision making. - Highlights: • Accident risks are compared across a broad range of energy technologies. • Analysis of historical experience was based on the

  16. Assessing functional ability in older patients

    DEFF Research Database (Denmark)

    Nielsen, Louise Møldrup; Maribo, Thomas; Nielsen, Hanne Grethe

    2014-01-01

    from the hospital expressed a need for a fast and simple screening tool to identify those in need of further rehabilitation and care after discharge. Participants from the municipality expressed a need for a more detailed assessment tool to capture information about patients’ ability to perform daily...

  17. Relationship between functional connectivity and motor function assessment in stroke patients with hemiplegia: a resting-state functional MRI study

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Ye; Wang, Li; Zhang, Jingna; Sang, Linqiong; Li, Pengyue; Qiu, Mingguo [Third Military Medical University, Department of Medical Imaging, College of Biomedical Engineering, Chongqing (China); Liu, Hongliang; Yan, Rubing [Third Military Medical University, Department of Rehabilitation, Southwest Hospital, Chongqing (China); Yang, Jun; Wang, Jian [Third Military Medical University, Department of Radiology, Southwest Hospital, Chongqing (China)

    2016-05-15

    Resting-state functional magnetic resonance imaging (fMRI) has been used to examine the brain mechanisms of stroke patients with hemiplegia, but the relationship between functional connectivity (FC) and treatment-induced motor function recovery has not yet been fully investigated. This study aimed to identify the brain FC changes in stroke patients and study the relationship between FC and motor function assessment using the resting-state fMRI. Seventeen stroke patients with hemiplegia and fifteen healthy control subjects (HCSs) were recruited in this study. We compared the FC between the ipsilesional primary motor cortex (M1) and the whole brain of the patients with the FC of the HCSs and studied the FC changes in the patients before and after conventional rehabilitation and motor imagery therapy. Additionally, correlations between the FC change and motor function of the patients were studied. Compared to the HCSs, the FC in the patient group was significantly increased between the ipsilesional M1 and the ipsilesional inferior parietal cortex, frontal gyrus, supplementary motor area (SMA), and contralesional angular and decreased between the ipsilesional M1 and bilateral M1. After the treatment, the FC between the ipsilesional M1 and contralesional M1 increased while the FC between the ipsilesional M1 and ipsilesional SMA and paracentral lobule decreased. A statistically significant correlation was found between the FC change in the bilateral M1 and the Fugl-Meyer assessment (FMA) score change. Our results revealed an abnormal motor network after stroke and suggested that the FC could serve as a biomarker of motor function recovery in stroke patients with hemiplegia. (orig.)

  18. Relationship between functional connectivity and motor function assessment in stroke patients with hemiplegia: a resting-state functional MRI study

    International Nuclear Information System (INIS)

    Zhang, Ye; Wang, Li; Zhang, Jingna; Sang, Linqiong; Li, Pengyue; Qiu, Mingguo; Liu, Hongliang; Yan, Rubing; Yang, Jun; Wang, Jian

    2016-01-01

    Resting-state functional magnetic resonance imaging (fMRI) has been used to examine the brain mechanisms of stroke patients with hemiplegia, but the relationship between functional connectivity (FC) and treatment-induced motor function recovery has not yet been fully investigated. This study aimed to identify the brain FC changes in stroke patients and study the relationship between FC and motor function assessment using the resting-state fMRI. Seventeen stroke patients with hemiplegia and fifteen healthy control subjects (HCSs) were recruited in this study. We compared the FC between the ipsilesional primary motor cortex (M1) and the whole brain of the patients with the FC of the HCSs and studied the FC changes in the patients before and after conventional rehabilitation and motor imagery therapy. Additionally, correlations between the FC change and motor function of the patients were studied. Compared to the HCSs, the FC in the patient group was significantly increased between the ipsilesional M1 and the ipsilesional inferior parietal cortex, frontal gyrus, supplementary motor area (SMA), and contralesional angular and decreased between the ipsilesional M1 and bilateral M1. After the treatment, the FC between the ipsilesional M1 and contralesional M1 increased while the FC between the ipsilesional M1 and ipsilesional SMA and paracentral lobule decreased. A statistically significant correlation was found between the FC change in the bilateral M1 and the Fugl-Meyer assessment (FMA) score change. Our results revealed an abnormal motor network after stroke and suggested that the FC could serve as a biomarker of motor function recovery in stroke patients with hemiplegia. (orig.)

  19. Audit of carbapenem prescriptions comparing 2 assessment periods.

    Science.gov (United States)

    Lefébure, A; Papy, E; Rioux, C; Diamantis, S; Armand-Lefèvre, L; Longuet, P; Lescure, F X; Wolff, M; Arnaud, P; Lucet, J C

    2015-07-01

    The emergence of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae has resulted in the increase of carbapenem prescriptions. The objective of our study was to determine the appropriateness of carbapenem prescriptions from initiation to reassessment of treatment, between 2009 and 2011. A questionnaire drafted by infectious diseases specialists (IDS) and microbiologists was used to collect clinical and microbiological data concerning carbapenem prescriptions in 2009 and 2011. An IDS then compared the results to assess carbapenem prescription compliance with our hospital's local recommendations. Seventy-one prescriptions were included in 2009 and 32 in 2011. The carbapenem treatment had been most frequently probabilistic to treat nosocomial infections. The microbiological data revealed that the number of multidrug-resistant (MDR) infections had increased between 2009 and 2011, especially infections involving ESBL-producing Enterobacteriaceae. At treatment reassessment, in 2009 and 2011, 15 (21%) and 12 (38%) carbapenem prescriptions were appropriate and continued. Overall, when comparing the 2 periods, prescriptions complied with local guidelines from initiation to reassessment of treatment without any statistically significant difference (68% in 2009 and 75% in 2011). Our study results showed that MDR infections had increased and especially infections due to ESBL-producing Enterobacteriaceae; this was consistent with epidemiological data. We also proved that most carbapenem prescriptions were compliant with recommendations. The increased mobile IDS interventions in medical and surgical departments helped reach this rate of compliance. Carbapenem stewardship may be promoted even in a difficult epidemiological context, especially with IDS interventions for the duration of treatment or at treatment reassessment. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. Comparing the self-assessed and examiner-assessed driving skills of Japanese driving school students

    Directory of Open Access Journals (Sweden)

    Hiroshi Nakai

    2012-03-01

    A sample of Japanese driving test candidates (n=2021 completed a self-assessment using a 5-point scale applied to 19 items. The candidates completed the assessment shortly after passing their practical driving test conducted at a driving school. Their performance was also assessed by an examiner who used the same scale. The comparison between self-assessment and examiner-assessment revealed that around 40% of Japanese driving school students made a realistic assessment of their skills. With regard to the gender differences, although males displayed higher levels of overconfidence than females did, the differences were not as large as earlier studies with questionnaires had suggested. Furthermore, the effect of age on the accuracy of novice drivers' skill assessment was found to be relatively small. Our findings, which are based on a comparison of subjective assessments of driving skills between examiners and novices, instead of a questionable method which relies on a comparison with a hypothetical average driver, suggest that the majority of candidates in fact do not overrate their own skills. These results were discussed from the viewpoint of the driver education system and compared to other European research using the same framework.

  1. Comparative study of the uncertainties in parton distribution functions

    International Nuclear Information System (INIS)

    Alekhin, S.I.

    2003-01-01

    Comparison of the methods used to extract the uncertainties in parton distributions is given, including their statistical properties and practical issues of implementation. Advantages and disadvantages of different methods are illustrated using the examples based on the analysis of real data. Available PDFs sets with associated uncertainties are reviewed and critically compared

  2. Smile line assessment comparing quantitative measurement and visual estimation.

    Science.gov (United States)

    Van der Geld, Pieter; Oosterveld, Paul; Schols, Jan; Kuijpers-Jagtman, Anne Marie

    2011-02-01

    Esthetic analysis of dynamic functions such as spontaneous smiling is feasible by using digital videography and computer measurement for lip line height and tooth display. Because quantitative measurements are time-consuming, digital videography and semiquantitative (visual) estimation according to a standard categorization are more practical for regular diagnostics. Our objective in this study was to compare 2 semiquantitative methods with quantitative measurements for reliability and agreement. The faces of 122 male participants were individually registered by using digital videography. Spontaneous and posed smiles were captured. On the records, maxillary lip line heights and tooth display were digitally measured on each tooth and also visually estimated according to 3-grade and 4-grade scales. Two raters were involved. An error analysis was performed. Reliability was established with kappa statistics. Interexaminer and intraexaminer reliability values were high, with median kappa values from 0.79 to 0.88. Agreement of the 3-grade scale estimation with quantitative measurement showed higher median kappa values (0.76) than the 4-grade scale estimation (0.66). Differentiating high and gummy smile lines (4-grade scale) resulted in greater inaccuracies. The estimation of a high, average, or low smile line for each tooth showed high reliability close to quantitative measurements. Smile line analysis can be performed reliably with a 3-grade scale (visual) semiquantitative estimation. For a more comprehensive diagnosis, additional measuring is proposed, especially in patients with disproportional gingival display. Copyright © 2011 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

  3. Comparative assessment of electricity generation options in the Philippines

    International Nuclear Information System (INIS)

    Leonin, T.V.; Mundo, M.Q.; Venida, L.L.; Arriola, H.; Madrio, E.

    2001-01-01

    The development of a country specific data base on energy sources, facilities and technologies is presented in this paper. It also identified feasible national electricity generating options and electric power system expansion alternatives for the period 2000-2020, and conducted comparative assessments of these options based on economic and environmental considerations. The possible role of nuclear power in the country's future electric energy was also studied. The comparison of three electricity generating options were considered: coal-fired thermal power plant without flue gas desulfurization (FGD), coal-fired thermal power plant with FGD and combined cycle power plant with 300 MW generating capacity each. Based on the analysis of three alternatives, the use of coal-fired power plants equipped with flue gas desulfurization (FGD) should be seriously considered. The government is expected to pursue the full development of local energy sources such as hydropower, geothermal, coal, natural gas and other new and renewable energy sources. However, there will still be a major need for imported oil and coal fuel which will likely supply unidentified energy sources beyond 2010. In the case of nuclear power, the government has not firmed up definite plans for any construction of nuclear power plants after 2010. However, the long term energy development plan still includes the operation of at least two nuclear power plants by the 2020 and this long term range program has not been revised in the recent published updates. (Author)

  4. Cars and fuels for tomorrow: A comparative assessment

    International Nuclear Information System (INIS)

    Aahman, Max; Nilsson, Lars J.; Johansson, Bengt

    2001-01-01

    Light duty vehicles, i.e. passenger cars and light trucks, account for approximately half of global transportation energy demand and, thus, a major share of carbon dioxide and other emissions from the transport sector. Energy consumption in the transport sector is expected to grow in the future, especially in developing countries. Cars with alternative powertrains to internal combustion engines (notably battery, hybrid and fuel-cell powertrains), in combination with potentially low carbon electricity or alternative fuels (notably hydrogen and methanol), can reduce energy demand by at least 50%, and carbon dioxide and regulated emissions much further. This article presents a comparative technical and economic assessment of promising future fuel/vehicle combinations. There are several promising technologies but no obvious winners. However, the electric drivetrain is a common denominator in the alternative powertrains and continued cost reductions are important for widespread deployment in future vehicles. Development paths from current fossil fuel based systems to future carbon-neutral supply systems appear to be flexible and a gradual phasing-in of new powertrains and carbon-neutral fluid fuels or electricity is technically possible. Technology development drivers and vehicle manufacturers are found mainly in industrialised countries, but developing countries represent a growing market and may have an increasingly important role in shaping the future. (author)

  5. Assessment of left ventricular global function

    International Nuclear Information System (INIS)

    Breuel, H.-P.; Baehre, M.

    1985-01-01

    Radionuclide ventriculography (RNV), i.e. noninvasive evaluation of left venticular performance following the application of radionuclides has had a major impact on many aspects of cardiology and has proven its clinical value and reliability in the last few years. This article deals mainly with the changes in global left ventricular function. The clinical applications of RNV for coronary artery diseases and valvular heart diseases are described. (Auth.)

  6. International assessment of functional computer abilities

    OpenAIRE

    Anderson, Ronald E.; Collis, Betty

    1993-01-01

    After delineating the major rationale for computer education, data are presented from Stage 1 of the IEA Computers in Education Study showing international comparisons that may reflect differential priorities. Rapid technological change and the lack of consensus on goals of computer education impedes the establishment of stable curricula for ¿general computer education¿ or computer literacy. In this context the construction of instruments for student assessment remains a challenge. Seeking to...

  7. Structural and functional assessment of macula to diagnose glaucoma.

    Science.gov (United States)

    Rao, H L; Hussain, R S M; Januwada, M; Pillutla, L N; Begum, V U; Chaitanya, A; Senthil, S; Garudadri, C S

    2017-04-01

    PurposeTo compare the diagnostic abilities of structural (ganglion cell-inner plexiform layer (GCIPL) thickness measured using spectral domain optical coherence tomography (SDOCT)) and functional (visual sensitivities measured using standard automated perimetry (SAP) and microperimetry (MP)) assessments of macula in glaucoma.MethodsIn a prospective study, 46 control eyes (28 subjects) and 61 glaucoma eyes (46 patients) underwent visual sensitivity estimation at macula (central 10°) by SAP and MP, and GCIPL thickness measurement at macula by SDOCT. Glaucoma was diagnosed by experts based on the optic disc and retinal nerve fiber layer changes. Area under the receiver-operating characteristic (AUC) curves and sensitivities at 95% specificity were used to assess the diagnostic ability of visual sensitivity and GCIPL measurements at various macular sectors.ResultsAUCs of GCIPL parameters ranged between 0.58 and 0.79. AUCs of SAP and MP sensitivities ranged between 0.59 and 0.71, and 0.59 and 0.72, respectively. There were no statistically significant differences between the AUCs of corresponding sector measurements (P>0.10 for all comparisons). Sensitivities at 95% specificities ranged from 31-59% for GCIPL parameters, 16-34% for SAP, and 8-38% for MP parameters. Sensitivities were significantly better with GCIPL compared with SAP and MP parameters in diagnosing glaucoma. Inferotemporal, inferior, and superotemporal sector measurements of GCIPL and visual sensitivity showed the best abilities to diagnose glaucoma.ConclusionsComparing the diagnostic abilities of structural and functional tests at macula in glaucoma, GCIPL thickness measurements with SDOCT performed better than the visual sensitivity measurements by SAP and MP.

  8. Comparative evaluation of Plateletworks, Multiplate analyzer and Platelet function analyzer-200 in cardiology patients.

    Science.gov (United States)

    Kim, Jeeyong; Cho, Chi Hyun; Jung, Bo Kyeung; Nam, Jeonghun; Seo, Hong Seog; Shin, Sehyun; Lim, Chae Seung

    2018-04-14

    The objective of this study was to comparatively evaluate three commercial whole-blood platelet function analyzer systems: Platelet Function Analyzer-200 (PFA; Siemens Canada, Mississauga, Ontario, Canada), Multiplate analyzer (MP; Roche Diagnostics International Ltd., Rotkreuz, Switzerland), and Plateletworks Combo-25 kit (PLW; Helena Laboratories, Beaumont, TX, USA). Venipuncture was performed on 160 patients who visited a department of cardiology. Pairwise agreement among the three platelet function assays was assessed using Cohen's kappa coefficient and percent agreement within the reference limit. Kappa values with the same agonists were poor between PFA-collagen (COL; agonist)/adenosine diphosphate (ADP) and MP-ADP (-0.147), PFA-COL/ADP and PLW-ADP (0.089), MP-ADP and PLW-ADP (0.039), PFA-COL/ADP and MP-COL (-0.039), and between PFA-COL/ADP and PLW-COL (-0.067). Nonetheless, kappa values for the same assay principle with a different agonist were slightly higher between PFA-COL/ADP and PFA-COL/EPI (0.352), MP-ADP and MP-COL (0.235), and between PLW-ADP and PLW-COL (0.247). The range of percent agreement values was 38.7% to 73.8%. Therefore, various measurements of platelet function by more than one method were needed to obtain a reliable interpretation of platelet function considering low kappa coefficient and modest percent agreement rates among 3 different platelet function tests.

  9. A comparative study of density functional and density functional tight binding calculations of defects in graphene

    Energy Technology Data Exchange (ETDEWEB)

    Zobelli, Alberto [Laboratoire de Physique des Solides, Univ. Paris Sud, CNRS UMR, Orsay (France); Ivanovskaya, Viktoria; Wagner, Philipp; Yaya, Abu; Ewels, Chris P. [Institut des Materiaux Jean Rouxel (IMN), CNRS UMR, University of Nantes (France); Suarez-Martinez, Irene [Nanochemistry Research Institute, Curtin University of Technology, Perth, Western Australia (Australia)

    2012-02-15

    The density functional tight binding approach (DFTB) is well adapted for the study of point and line defects in graphene based systems. After briefly reviewing the use of DFTB in this area, we present a comparative study of defect structures, energies, and dynamics between DFTB results obtained using the dftb+ code, and density functional results using the localized Gaussian orbital code, AIMPRO. DFTB accurately reproduces structures and energies for a range of point defect structures such as vacancies and Stone-Wales defects in graphene, as well as various unfunctionalized and hydroxylated graphene sheet edges. Migration barriers for the vacancy and Stone-Wales defect formation barriers are accurately reproduced using a nudged elastic band approach. Finally we explore the potential for dynamic defect simulations using DFTB, taking as an example electron irradiation damage in graphene. DFTB-MD derived sputtering energy threshold map for a carbon atom in a graphene plane. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  10. A tool for assessing the feasibility of comparative effectiveness research

    Directory of Open Access Journals (Sweden)

    Walker AM

    2013-01-01

    Full Text Available Alexander M Walker,1 Amanda R Patrick,2 Michael S Lauer,3 Mark C Hornbrook,4 Matthew G Marin,5 Richard Platt,6 Véronique L Roger,7 Paul Stang,8 Sebastian Schneeweiss21World Health Information Science Consultants, Newton, MA; 2Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA; 3National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; 4The Center for Health Research, Kaiser Permanente Northwest, Portland, OR; 5Department of Medicine, New Jersey Medical School, Newark, NJ; 6Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA; 7Department of Health Sciences Research, Mayo Clinic, Rochester, MN; 8Johnson and Johnson Pharmaceutical Research and Development, Titusville, NJ, USABackground: Comparative effectiveness research (CER provides actionable information for health care decision-making. Randomized clinical trials cannot provide the patients, time horizons, or practice settings needed for all required CER. The need for comparative assessments and the infeasibility of conducting randomized clinical trials in all relevant areas is leading researchers and policy makers to non-randomized, retrospective CER. Such studies are possible when rich data exist on large populations receiving alternative therapies that are used as-if interchangeably in clinical practice. This setting we call “empirical equipoise.”Objectives: This study sought to provide a method for the systematic identification of settings it in which it is empirical equipoise that offers promised non-randomized CER.Methods: We used a standardizing transformation of the propensity score called “preference” to assess pairs of common treatments for uncomplicated community-acquired pneumonia and new-onset heart failure in a population of low-income elderly people in Pennsylvania, for whom we had access to de-identified insurance records. Treatment

  11. A comparative assessment of endogenous water institutional change

    Science.gov (United States)

    Pande, Saket; Ersten, Maurits

    2013-04-01

    This paper builds the theory of endogenous institutional change, first proposed by Greif and Laitin (2004), for water scarce regions in context of water institutions. The current emphasis on environmental change, including hydrological change, largely ignores the adaptation of human societies to change. Humans have mostly been considered as boundary conditions or parameters of the dynamics of hydrological change and are not considered as conduits of feedbacks. Nonetheless, the dynamical representation of hydrological change with feedbacks between various components of a system is assuring since it is reminiscent of processual ecological anthropology(Orlove, 1980), except that individual decision making is absent. This paper proposes to consider selected dryland basins of the world, to conceptualize proxies of water relevant socio-economic organisation, such as spatial scales of upstream-downstream cooperation in water use, synthesized over time and then proposes a comparative assessment to test regularities predicted by an extension of river game theory (Ambec and Ehlers, 2008; van der Brink et al, 2012) to endogenous institutional change. References: Orlove, B. S. (1980). Ecological Anthropology. Annual Review of Anthropology, Vol. 9 (1980), pp. 235-273. Greif. A. and D. D. Laitin (2004). A Theory of Endogenous Institutional Change. American Political Science Review, Vol. 98, No. 4 November 2004. Ambec, S. and L. Ehlers (2008). Sharing a river amongst satiable agents. Games and Economic Behavior, 64, 35-50. Van der Brink, G. van der Laan and N. Moes (2012). Fair agreements for sharing international rivers with multiple springs and externalities. Journal of Environmental Economics and Management, 63, 388-403.

  12. Road Maintenance and Rehabilitation Program Using Functional and Structural Assessment

    Science.gov (United States)

    Setianingsih, A. I.; Sangaji, S.; Setyawan, A.

    2017-02-01

    Road sector development policy in Bangka Belitung emphasis on equitable development, which is opening up new areas for industrial development zones of potential marine and coastal tourism, so that having an impact on the budget priority to build a new road. This led to a minimal budget provided for the maintenance of the existing road. This study aimed to evaluate the condition of the pavement both functionally and structurally, the growth of traffic density and the availability of existing road maintenance costs. Then, to analyze the influence of existing road conditions, traffic density and road maintenance costs to the type of road maintenance management. The results are compared with the results of the existing maintenance conducted by the Public Works Department of Bangka Belitung province. Evaluation of pavement conditions consists of visual assessment of pavement condition using IRI, pavement condition assessment functionally with deflection method using test data tool Benkelman Beam (BB) and the actual traffic load. IRI value, deflections and traffic growth gained from years 2011-2015 subsequently created regression models to obtain the relationship and the correlation coefficient. The analysis showed that using the same relative magnitude of the budget from 2011 to 2015, giving priority to the maintenance of the road with good conditions capable of providing the road with a steady state of 100%. Recommendations can be given that maintain the road with good conditions reflecting that preservation provide maximum results with the more efficient maintenance cost.

  13. Assessment of smoothed spectra using autocorrelation function

    International Nuclear Information System (INIS)

    Urbanski, P.; Kowalska, E.

    2006-01-01

    Recently, data and signal smoothing became almost standard procedures in the spectrometric and chromatographic methods. In radiometry, the main purpose to apply smoothing is minimisation of the statistical fluctuation and avoid distortion. The aim of the work was to find a qualitative parameter, which could be used, as a figure of merit for detecting distortion of the smoothed spectra, based on the linear model. It is assumed that as long as the part of the raw spectrum removed by the smoothing procedure (v s ) will be of random nature, the smoothed spectrum can be considered as undistorted. Thanks to this feature of the autocorrelation function, drifts of the mean value in the removed noise vs as well as its periodicity can be more easily detected from the autocorrelogram than from the original data

  14. Comparative and developmental patterns of amphibious auditory function in salamanders.

    Science.gov (United States)

    Zeyl, Jeffrey N; Johnston, Carol E

    2016-12-01

    Early amphibious tetrapods may have detected aquatic sound pressure using sound-induced lung vibrations, but their lack of tympanic middle ears would have restricted aerial sensitivity. Sharing these characteristics, salamanders could be models for the carryover of auditory function across an aquatic-terrestrial boundary without tympanic middle ears. We measured amphibious auditory evoked potential audiograms in five phylogenetically and ecologically distinct salamanders (Amphiuma means, Notophthalmus viridescens, Ambystoma talpoideum, Eurycea spp., and Plethodon glutinosus) and tested whether metamorphosis and terrestrial niche were linked to aerial sensitivity. Threshold differences between media varied between species. A. means' relative aerial sensitivity was greatest at 100 Hz and decreased with increasing frequency. In contrast, all other salamanders retained greater sensitivity up to 500 Hz, and in A. talpoideum and Eurycea, relative sensitivity at 500 Hz was higher than at 100 Hz. Aerial thresholds of terrestrial P. glutinosus above 200 Hz were similar to A. talpoideum and Eurycea, but lower than N. viridescens and A. means. Metamorphosis did not affect aerial sensitivity in N. viridescens or A. talpoideum. These results fail to support a hypothesis of terrestrial hearing specialization across ontogeny or phylogeny. We discuss methodological limitations to our amphibious comparisons and factors affecting variation in amphibious performance.

  15. Comparative functional scintigraphic and angiographic examination in pancreas diseases

    International Nuclear Information System (INIS)

    Mendizov, A.; Brilski, V.; Bozhiyanov, A.; Romanova, A.; Mardzhanov, I.; Glavincheva, I.; Meditsinska Akademiya, Sofia

    1979-01-01

    Pancreas scintigraphy with 75 seleno-methionine, pancreocimine-secretine test and selective abdominal angiography was carried out in patients with chronic pancreatitis, pancreas carcinoma and subjects without any pancreas diseases. Scintigraphic changes in pancreas was found in 95,6 per cent of the patients with chronic pancreatitis (136 patients), in 92 per cent of them with pancreas carcinoma (25 patients) and in 53,4 per cent from the subjects without pancreas diseases (30 examined). Pathological changes in pancreatic secretion was found in 93,4 per cent of the patients with chronic pancreatitis (105 patients), in 93,8 per cent of the subjects with pancreas carcinoma (32 patients) and only in 3,9 per cent from the examined without pancreatic diseases. The angiographic examination is informative mainly in case of tumours and cysts of the pancreas. The diagnostic potentialities of the separate methods for pancreas examination were critically assessed. The basic diagnostic problems in pancreas diseases are solved to a great extent with the combined examination with scintigraphy pancreocimine test and angiography (76 patients). (author)

  16. Comparative study for environmental assessment by program characters

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Suk Chul; Lee, Young Soo; Park, Young Min; Park, Suk Soon; Chung, Kyung Tae; Cho, Hong Yun; Chae, Jang Won; Lee, Sang Don; Lee, Chan Ho; Choi, Joon Kyu; Kim, Kang Joo; Chung, Won Moo; Jin, Jae Yool [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    The level of environmental assessment in Korea was diagnosed by examining the situation of its model for the entire environmental assessment implemented. Also, it proposed an improvement scheme for its problems to be able to advance. It is expected to be utilized as developing optimum model for Korea and establishing a systematic and concrete guideline for environmental assessment modeling. 244 refs., 65 figs., 28 tabs.

  17. Self Assessment in Schizophrenia: Accuracy of Evaluation of Cognition and Everyday Functioning

    Science.gov (United States)

    Gould, Felicia; McGuire, Laura Stone; Durand, Dante; Sabbag, Samir; Larrauri, Carlos; Patterson, Thomas L.; Twamley, Elizabeth W.; Harvey, Philip D.

    2015-01-01

    Objective Self-assessment deficits, often referred to as impaired insight or unawareness of illness, are well established in people with schizophrenia. There are multiple levels of awareness, including awareness of symptoms, functional deficits, cognitive impairments, and the ability to monitor cognitive and functional performance in an ongoing manner. The present study aimed to evaluate the comparative predictive value of each aspect of awareness on the levels of everyday functioning in people with schizophrenia. Method We examined multiple aspects of self-assessment of functioning in 214 people with schizophrenia. We also collected information on everyday functioning rated by high contact clinicians and examined the importance of self-assessment for the prediction of real world functional outcomes. The relative impact of performance based measures of cognition, functional capacity, and metacognitive performance on everyday functioning was also examined. Results Misestimation of ability emerged as the strongest predictor of real world functioning and exceeded the influences of cognitive performance, functional capacity performance, and performance-based assessment of metacognitive monitoring. The relative contribution of the factors other than self-assessment varied according to which domain of everyday functioning was being examined, but in all cases, accounted for less predictive variance. Conclusions These results underscore the functional impact of misestimating one’s current functioning and relative level of ability. These findings are consistent with the use of insight-focused treatments and compensatory strategies designed to increase self-awareness in multiple functional domains. PMID:25643212

  18. Self-assessment in schizophrenia: Accuracy of evaluation of cognition and everyday functioning.

    Science.gov (United States)

    Gould, Felicia; McGuire, Laura Stone; Durand, Dante; Sabbag, Samir; Larrauri, Carlos; Patterson, Thomas L; Twamley, Elizabeth W; Harvey, Philip D

    2015-09-01

    Self-assessment deficits, often referred to as impaired insight or unawareness of illness, are well established in people with schizophrenia. There are multiple levels of awareness, including awareness of symptoms, functional deficits, cognitive impairments, and the ability to monitor cognitive and functional performance in an ongoing manner. The present study aimed to evaluate the comparative predictive value of each aspect of awareness on the levels of everyday functioning in people with schizophrenia. We examined multiple aspects of self-assessment of functioning in 214 people with schizophrenia. We also collected information on everyday functioning rated by high contact clinicians and examined the importance of self-assessment for the prediction of real-world functional outcomes. The relative impact of performance-based measures of cognition, functional capacity, and metacognitive performance on everyday functioning was also examined. Misestimation of ability emerged as the strongest predictor of real-world functioning and exceeded the influences of cognitive performance, functional capacity performance, and performance-based assessment of metacognitive monitoring. The relative contribution of the factors other than self-assessment varied according to which domain of everyday functioning was being examined, but, in all cases, accounted for less predictive variance. These results underscore the functional impact of misestimating one's current functioning and relative level of ability. These findings are consistent with the use of insight-focused treatments and compensatory strategies designed to increase self-awareness in multiple functional domains. (c) 2015 APA, all rights reserved).

  19. Protein Comparability Assessments and Potential Applicability of High Throughput Biophysical Methods and Data Visualization Tools to Compare Physical Stability Profiles

    Directory of Open Access Journals (Sweden)

    Mohammad A. Alsenaidy

    2014-03-01

    Full Text Available In this review, some of the challenges and opportunities encountered during protein comparability assessments are summarized with an emphasis on developing new analytical approaches to better monitor higher-order protein structures. Several case studies are presented using high throughput biophysical methods to collect protein physical stability data as function of temperature, agitation, ionic strength and/or solution pH. These large data sets were then used to construct empirical phase diagrams (EPDs, radar charts, and comparative signature diagrams (CSDs for data visualization and structural comparisons between the different proteins. Protein samples with different sizes, post-translational modifications, and inherent stability are presented: acidic fibroblast growth factor (FGF-1 mutants, different glycoforms of an IgG1 mAb prepared by deglycosylation, as well as comparisons of different formulations of an IgG1 mAb and granulocyte colony stimulating factor (GCSF. Using this approach, differences in structural integrity and conformational stability profiles were detected under stress conditions that could not be resolved by using the same techniques under ambient conditions (i.e., no stress. Thus, an evaluation of conformational stability differences may serve as an effective surrogate to monitor differences in higher-order structure between protein samples. These case studies are discussed in the context of potential utility in protein comparability studies.

  20. Protein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profiles.

    Science.gov (United States)

    Alsenaidy, Mohammad A; Jain, Nishant K; Kim, Jae H; Middaugh, C Russell; Volkin, David B

    2014-01-01

    In this review, some of the challenges and opportunities encountered during protein comparability assessments are summarized with an emphasis on developing new analytical approaches to better monitor higher-order protein structures. Several case studies are presented using high throughput biophysical methods to collect protein physical stability data as function of temperature, agitation, ionic strength and/or solution pH. These large data sets were then used to construct empirical phase diagrams (EPDs), radar charts, and comparative signature diagrams (CSDs) for data visualization and structural comparisons between the different proteins. Protein samples with different sizes, post-translational modifications, and inherent stability are presented: acidic fibroblast growth factor (FGF-1) mutants, different glycoforms of an IgG1 mAb prepared by deglycosylation, as well as comparisons of different formulations of an IgG1 mAb and granulocyte colony stimulating factor (GCSF). Using this approach, differences in structural integrity and conformational stability profiles were detected under stress conditions that could not be resolved by using the same techniques under ambient conditions (i.e., no stress). Thus, an evaluation of conformational stability differences may serve as an effective surrogate to monitor differences in higher-order structure between protein samples. These case studies are discussed in the context of potential utility in protein comparability studies.

  1. Comparative Evolution of Morphological Regulatory Functions in Candida Species

    Science.gov (United States)

    Lackey, Erika; Vipulanandan, Geethanjali; Childers, Delma S.

    2013-01-01

    Morphological transitions play an important role in virulence and virulence-related processes in a wide variety of pathogenic fungi, including the most commonly isolated human fungal pathogen Candida albicans. While environmental signals, transcriptional regulators, and target genes associated with C. albicans morphogenesis are well-characterized, considerably little is known about morphological regulatory mechanisms and the extent to which they are evolutionarily conserved in less pathogenic and less filamentous non-albicans Candida species (NACS). We have identified specific optimal filament-inducing conditions for three NACS (C. tropicalis, C. parapsilosis, and C. guilliermondii), which are very limited, suggesting that these species may be adapted for niche-specific filamentation in the host. Only a subset of evolutionarily conserved C. albicans filament-specific target genes were induced upon filamentation in C. tropicalis, C. parapsilosis, and C. guilliermondii. One of the genes showing conserved expression was UME6, a key filament-specific regulator of C. albicans hyphal development. Constitutive high-level expression of UME6 was sufficient to drive increased filamentation as well as biofilm formation and partly restore conserved filament-specific gene expression in both C. tropicalis and C. parapsilosis, suggesting that evolutionary differences in filamentation ability among pathogenic Candida species may be partially attributed to alterations in the expression level of a conserved filamentous growth machinery. In contrast to UME6, NRG1, an important repressor of C. albicans filamentation, showed only a partly conserved role in controlling NACS filamentation. Overall, our results suggest that C. albicans morphological regulatory functions are partially conserved in NACS and have evolved to respond to more specific sets of host environmental cues. PMID:23913541

  2. A comparative study of single and multiple hand tasks using functional MRI

    International Nuclear Information System (INIS)

    Shin, Byung Suck; Lee, Ho Kyu; Park, Sung Tae; Kim, Dong Eun; Lee, Myung Jun; Choi, Choong Gon; Kim, Jae Kyun; Suh, Dae Chul; Lim, Tae Hwan

    1998-01-01

    The purpose of this study is to assess, using functional MRI and by comparing activated motor sensory areas, the independence of brain activation during single and alternative multiple hand tasks. The subjects were six healthy volunteers. Using at 1.5T Siemens system and single shot FID-EPI sequencing (T2 weighted image; TR/TE 0.96 msec/ 61msec, flip angle 90 deg, matrix size 96 x 128, slice thickness/gap 5 mm/0.8 mm, FOV 200 mm) and T1-weighted anatomic images, functional MRI was performed. The paradigm of motor tasks consisted of appositional finger movements; the first involved the separate use of the right, left, and both hands in sequence. Using cross-correlation method (threshold : 0.6) and fMRI analysis software (stimulate 5.0), functional images were obtained. The activated area of brain cortex, the number of pixel, the average percentage change in signal intensity, and correlation of the time-signal intensity curve in the activated motor area were analysed and compared between the two task groups. Statistical analysis involved the use of Wilcoxon signed-rank test. Brain activation did not differ according to whether the motor task was single or alternative. We therefore suggest that during multiple stimuli, the relevant functional area and neuronal column are activated independently. (author). 19 refs., 2 tabs., 3 figs

  3. [Role of aerodynamic parameters in voice function assessment].

    Science.gov (United States)

    Guo, Yong-qing; Lin, Sheng-zhi; Xu, Xin-lin; Zhou, Li; Zhuang, Pei-yun; Jiang, Jack J

    2012-10-01

    To investigate the application and significance of aerodynamic parameters in voice function assessment. The phonatory aerodynamic system (PAS) was used to collect aerodynamic parameters from subjects with normal voice, vocal fold polyp, vocal fold cyst, and vocal fold immobility. Multivariate statistical analysis was used to compare measurements across groups. Phonation threshold flow (PTF), mean flow rate (MFR), maximum phonation time (MPT), and glottal resistance (GR) in one hundred normal subjects were significantly affected by sex (P efficiency (VE) were not (P > 0.05). PTP, PTF, MFR, SGP, and MPT were significantly different between normal voice and voice disorders (P 0.05). Receiver operating characteristic (ROC) analysis found that PTP, PTF, SGP, MFR, MPT, and VE in one hundred thirteen voice dis orders had similar diagnostic utility (P aerodynamic parameters of the three degrees of voice dysfunction due to vocal cord polyps were compared and found to have no significant differences (P > 0.05). PTP, PTF, MFR, SGP and MPT in forty one patients with vocal polyps were significantly different after surgical resection of vocal cord polyps (P aerodynamic parameters can objectively and effectively evaluate the variations of vocal function, and have good auxiliary diagnostic value.

  4. Exorcising spent fuel transportation using comparative hazard assessment methods

    International Nuclear Information System (INIS)

    Pennington, Charles W.

    2003-01-01

    Spent fuel transportation has achieved an exemplary safety record over more than three decades within both the United States (U.S.) and the global community at large. Today, many groups are attempting to precipitate fear of spent fuel transportation within the general public by 'demonizing' this proven technology and by creating a highly charged environment of radiation phobia. The actions of these groups within the U.S. result from the confluence of the terrorist acts of September 11, 2001, and the acceptance by the President and Congress of the U.S. Department of Energy's (DOE) recommendation of Yucca Mountain as the repository site for the disposal of the nation's spent fuel. This paper offers a comparative hazard assessment demonstrating the relative safety of spent fuel transportation in the context of currently accepted practices within society to show that there are no 'demons' associated with spent fuel transportation. The paper provides an assessment of potential population exposures based on more than 25 years of transport cask analysis and testing under beyond-design-basis (BDB) event conditions, including missile attacks, with those from current accepted activities within society that produce high dose exposures to the general public. Over the last quarter of a century, several spent fuel cask test programs have produced data that allow calculation of potential releases and population doses resulting from a terrorist attack. The DOE has used this information to develop projected worst-case population exposures as part of the Final Environmental Impact Statement (FEIS) for the Yucca Mountain repository. The paper discusses these potential releases and population exposures. Additionally, the paper identifies current unregulated activities and practices within societies yielding population exposures that exceed significantly those that would result from such highly hypothetical and improbable events as a terrorist missile attack on a spent fuel

  5. Exorcising spent fuel transportation using comparative hazard assessment methods

    Energy Technology Data Exchange (ETDEWEB)

    Pennington, Charles W. [NAC international, Norcross (United States)

    2003-07-01

    Spent fuel transportation has achieved an exemplary safety record over more than three decades within both the United States (U.S.) and the global community at large. Today, many groups are attempting to precipitate fear of spent fuel transportation within the general public by 'demonizing' this proven technology and by creating a highly charged environment of radiation phobia. The actions of these groups within the U.S. result from the confluence of the terrorist acts of September 11, 2001, and the acceptance by the President and Congress of the U.S. Department of Energy's (DOE) recommendation of Yucca Mountain as the repository site for the disposal of the nation's spent fuel. This paper offers a comparative hazard assessment demonstrating the relative safety of spent fuel transportation in the context of currently accepted practices within society to show that there are no 'demons' associated with spent fuel transportation. The paper provides an assessment of potential population exposures based on more than 25 years of transport cask analysis and testing under beyond-design-basis (BDB) event conditions, including missile attacks, with those from current accepted activities within society that produce high dose exposures to the general public. Over the last quarter of a century, several spent fuel cask test programs have produced data that allow calculation of potential releases and population doses resulting from a terrorist attack. The DOE has used this information to develop projected worst-case population exposures as part of the Final Environmental Impact Statement (FEIS) for the Yucca Mountain repository. The paper discusses these potential releases and population exposures. Additionally, the paper identifies current unregulated activities and practices within societies yielding population exposures that exceed significantly those that would result from such highly hypothetical and improbable events as a terrorist missile

  6. Comparing the innovation effects of support schemes for renewable electricity technologies: A function of innovation approach

    International Nuclear Information System (INIS)

    Río, Pablo del; Bleda, Mercedes

    2012-01-01

    The aim of this paper is to provide a comparative assessment of the innovation effects of instruments which support the diffusion of renewable electricity technologies with a functions-oriented technological innovation system perspective. The paper provides a link between two major streams of the literature: the functions of innovation systems and the literature on renewable electricity support schemes. We show that, when a functional perspective is adopted, feed-in tariffs are likely to be superior to other policy instruments (quotas with tradable green certificates and tendering), although they still need to be complemented with other instruments, most importantly, direct R and D support. Furthermore, those innovation effects are affected by the specific design elements of the instruments chosen. - Highlights: ► A comparison of the innovation effects of instruments for the diffusion of renewable technologies. ► A functions-oriented technological innovation system perspective. ► A link between the functions of innovation systems and the literature on renewable electricity support schemes. ► Feed-in tariffs are likely to be superior to other instruments. ► Innovation effects are affected by the specific design elements of instruments.

  7. A virtual shopping test for realistic assessment of cognitive function.

    Science.gov (United States)

    Okahashi, Sayaka; Seki, Keiko; Nagano, Akinori; Luo, Zhiwei; Kojima, Maki; Futaki, Toshiko

    2013-06-18

    Cognitive dysfunction caused by brain injury often prevents a patient from achieving a healthy and high quality of life. By now, each cognitive function is assessed precisely by neuropsychological tests. However, it is also important to provide an overall assessment of the patients' ability in their everyday life. We have developed a Virtual Shopping Test (VST) using virtual reality technology. The objective of this study was to clarify 1) the significance of VST by comparing VST with other conventional tests, 2) the applicability of VST to brain-damaged patients, and 3) the performance of VST in relation to age differences. The participants included 10 patients with brain damage, 10 age-matched healthy subjects for controls, 10 old healthy subjects, and 10 young healthy subjects. VST and neuropsychological tests/questionnaires about attention, memory and executive function were conducted on the patients, while VST and the Mini-Mental State Examination (MMSE) were conducted on the controls and healthy subjects. Within the VST, the participants were asked to buy four items in the virtual shopping mall quickly in a rational way. The score for evaluation included the number of items bought correctly, the number of times to refer to hints, the number of movements between shops, and the total time spent to complete the shopping. Some variables on VST correlated with the scores of conventional assessment about attention and everyday memory. The mean number of times referring to hints and the mean number of movements were significantly larger for the patients with brain damage, and the mean total time was significantly longer for the patients than for the controls. In addition, the mean total time was significantly longer for the old than for the young. The results suggest that VST is able to evaluate the ability of attention and everyday memory in patients with brain damage. The time of VST is increased by age.

  8. Smile line assessment comparing quantitative measurement and visual estimation

    NARCIS (Netherlands)

    Geld, P. Van der; Oosterveld, P.; Schols, J.; Kuijpers-Jagtman, A.M.

    2011-01-01

    INTRODUCTION: Esthetic analysis of dynamic functions such as spontaneous smiling is feasible by using digital videography and computer measurement for lip line height and tooth display. Because quantitative measurements are time-consuming, digital videography and semiquantitative (visual) estimation

  9. A Comparative Assessment of Herbal and Orthodox Medicines in ...

    African Journals Online (AJOL)

    PROMOTING ACCESS TO AFRICAN RESEARCH ... This paper assessed the attributes of herbal and orthodox medicines such as affordability, packaging, ... Results showed that the respondents rated herbal medicines higher than orthodox ...

  10. Comparative life cycle assessment of wastewater treatment in Denmark including sensitivity and uncertainty analysis

    DEFF Research Database (Denmark)

    Niero, Monia; Pizzol, Massimo; Gundorph Bruun, Henrik

    2014-01-01

    Wastewater treatment has nowadays multiple functions and produces both clean effluents and sludge, which is increasingly seen as a resource rather than a waste product. Technological as well as management choices influence the performance of wastewater treatment plants (WWTPs) on the multiple...... functions. In this context, Life Cycle Assessment (LCA) can determine what choices provide the best environmental performance. However, the assessment is not straightforward due to the intrinsic space and time-related variability of the wastewater treatment process. These challenges were addressed...... in a comparative LCA of four types of WWTPs, representative of mainstream treatment options in Denmark. The four plant types differ regarding size and treatment technology: aerobic versus anaerobic, chemical vs. combined chemical and biological. Trade-offs in their environmental performance were identified...

  11. Are All Assessments Equal? The Comparability of Demands of College-Based Assessments in a Vocationally Related Qualification

    Science.gov (United States)

    Crisp, Victoria; Novakovic, Nadezda

    2009-01-01

    The consistency of assessment demands is important to validity. This research investigated the comparability of the demands of college-assessed units within a vocationally related qualification, drawing on methodological approaches that have previously been used to compare assessments. Assessment materials from five colleges were obtained. After…

  12. A Function-Based Framework for Stream Assessment & Restoration Projects

    Science.gov (United States)

    This report lays out a framework for approaching stream assessment and restoration projects that focuses on understanding the suite of stream functions at a site in the context of what is happening in the watershed.

  13. Accountability for Early Childhood Education (Assessing Global Functioning).

    Science.gov (United States)

    Cassel, Russell N.

    1995-01-01

    Discusses the pacing of learning activity, knowledge of progress in student learning, teacher role, accountability in learning, feedback on knowledge of success, the global functioning assessment concept, and the mother surrogate. (RS)

  14. Comparative availability and reliability assessment of design options for the secondary sodium loops of the EFR

    International Nuclear Information System (INIS)

    Pamme, H.

    1989-01-01

    The EFR (European Fast Reactor) project has entered a conceptual study period where different design alternatives are compared concerning feasibility, safety and economic aspects. This paper describes a comparative probabilistic availability and reliability assessment of alternative design options for the secondary sodium loops. These loops will provide heat transfer from the reactor pool to the water-steam (power generating) side. So a high operational availability of the secondary loops during plant lifetime is essential for economic power generation. Additionally a high reliability is required to fulfill the operational decay heat removal function in case of a reactor trip. Availabilities and reliabilities of the different options were assessed using failure mode and effect analysis and the fault tree method. (orig.)

  15. Comparative study of biodegradability prediction of chemicals using decision trees, functional trees, and logistic regression.

    Science.gov (United States)

    Chen, Guangchao; Li, Xuehua; Chen, Jingwen; Zhang, Ya-Nan; Peijnenburg, Willie J G M

    2014-12-01

    Biodegradation is the principal environmental dissipation process of chemicals. As such, it is a dominant factor determining the persistence and fate of organic chemicals in the environment, and is therefore of critical importance to chemical management and regulation. In the present study, the authors developed in silico methods assessing biodegradability based on a large heterogeneous set of 825 organic compounds, using the techniques of the C4.5 decision tree, the functional inner regression tree, and logistic regression. External validation was subsequently carried out by 2 independent test sets of 777 and 27 chemicals. As a result, the functional inner regression tree exhibited the best predictability with predictive accuracies of 81.5% and 81.0%, respectively, on the training set (825 chemicals) and test set I (777 chemicals). Performance of the developed models on the 2 test sets was subsequently compared with that of the Estimation Program Interface (EPI) Suite Biowin 5 and Biowin 6 models, which also showed a better predictability of the functional inner regression tree model. The model built in the present study exhibits a reasonable predictability compared with existing models while possessing a transparent algorithm. Interpretation of the mechanisms of biodegradation was also carried out based on the models developed. © 2014 SETAC.

  16. Speed and capacity of working memory and executive function in schizophrenia compared to unipolar depression

    Directory of Open Access Journals (Sweden)

    Wolfgang Trapp

    2017-12-01

    Full Text Available Schizophrenia is associated with deficits in working memory (WM and executive functioning (EF that are present from prodrome to chronic stages of the disease and are related to social and occupational functioning. Recent empirical findings suggest that schizophrenia patients might suffer from a specific speed deficit regarding WM operations that also affects EF. To test this hypothesis, executive functioning (EF and working memory (WM performance of 20 schizophrenia (SC patients, 20 patients suffering from Major Depressive Disorder (MDD and 40 healthy control (HC subjects were compared. While schizophrenia patients performed worse in the measure of EF, no difference between the SC and the MDD patients was found regarding WM capacity. However, the SC group was shown to have an impaired speed in encoding, retrieval and manipulation of WM contents compared to the HC group whereas the MDD group showed no such deficit. Furthermore, while in the MDD group only WM capacity was linked to EF performance, in the SC group EF was determined by both WM capacity and WM speed. Hence, increasing the speed of WM operations might be a fruitful target for future therapeutic interventions, and assessing not only the capacity but also the speed of WM might be helpful in identifying candidates for endophenotypic cognitive markers of SC.

  17. Comparing the Structure-Function Relationship at the Macula With Standard Automated Perimetry and Microperimetry.

    Science.gov (United States)

    Rao, Harsha L; Januwada, Manideepak; Hussain, Raza S M; Pillutla, Lalitha N; Begum, Viquar U; Chaitanya, Aditya; Senthil, Sirisha; Garudadri, Chandra S

    2015-12-01

    To compare the structure-function relationship between ganglion cell-inner plexiform layer (GCIPL) thickness measurements using spectral-domain optical coherence tomography (SDOCT) and visual sensitivities measured using standard automated perimetry (SAP) and microperimetry (MP) at the macula in glaucoma. In a prospective study, 45 control eyes (29 subjects) and 60 glaucoma eyes (45 patients) underwent visual sensitivity estimation at the macula (central 10°) by SAP and MP, and GCIPL thickness measurement at the macula by SDOCT. Structure-function relationships between GCILP thickness and visual sensitivity loss with SAP and MP at various macular sectors were assessed using the Hood and Kardon model. To compare structure-function relationship with SAP and MP, we calculated the number of data points falling outside the 5th and the 95th percentile values of the Hood and Kardon model with each of the perimeters. The number of points falling outside the 5th and 95th percentile values of the Hood and Kardon model ranged from 28 (superior sector) to 48 (inferonasal sector) with SAP and 33 (superior sector) to 49 (inferonasal sector) with MP. The difference in the number of points falling outside the 5th and 95th percentile values with SAP and MP was statistically insignificant (P > 0.05, χ(2) test) for all the sectors. Visual sensitivity measurements of both SAP and MP demonstrated a similar relationship with the GCIPL measurements of SDOCT at the macula in glaucoma.

  18. Comparative Probabilistic Assessment of Occupational Pesticide Exposures Based on Regulatory Assessments

    Science.gov (United States)

    Pouzou, Jane G.; Cullen, Alison C.; Yost, Michael G.; Kissel, John C.; Fenske, Richard A.

    2018-01-01

    Implementation of probabilistic analyses in exposure assessment can provide valuable insight into the risks of those at the extremes of population distributions, including more vulnerable or sensitive subgroups. Incorporation of these analyses into current regulatory methods for occupational pesticide exposure is enabled by the exposure data sets and associated data currently used in the risk assessment approach of the Environmental Protection Agency (EPA). Monte Carlo simulations were performed on exposure measurements from the Agricultural Handler Exposure Database and the Pesticide Handler Exposure Database along with data from the Exposure Factors Handbook and other sources to calculate exposure rates for three different neurotoxic compounds (azinphos methyl, acetamiprid, emamectin benzoate) across four pesticide-handling scenarios. Probabilistic estimates of doses were compared with the no observable effect levels used in the EPA occupational risk assessments. Some percentage of workers were predicted to exceed the level of concern for all three compounds: 54% for azinphos methyl, 5% for acetamiprid, and 20% for emamectin benzoate. This finding has implications for pesticide risk assessment and offers an alternative procedure that may be more protective of those at the extremes of exposure than the current approach. PMID:29105804

  19. Comparative Probabilistic Assessment of Occupational Pesticide Exposures Based on Regulatory Assessments.

    Science.gov (United States)

    Pouzou, Jane G; Cullen, Alison C; Yost, Michael G; Kissel, John C; Fenske, Richard A

    2017-11-06

    Implementation of probabilistic analyses in exposure assessment can provide valuable insight into the risks of those at the extremes of population distributions, including more vulnerable or sensitive subgroups. Incorporation of these analyses into current regulatory methods for occupational pesticide exposure is enabled by the exposure data sets and associated data currently used in the risk assessment approach of the Environmental Protection Agency (EPA). Monte Carlo simulations were performed on exposure measurements from the Agricultural Handler Exposure Database and the Pesticide Handler Exposure Database along with data from the Exposure Factors Handbook and other sources to calculate exposure rates for three different neurotoxic compounds (azinphos methyl, acetamiprid, emamectin benzoate) across four pesticide-handling scenarios. Probabilistic estimates of doses were compared with the no observable effect levels used in the EPA occupational risk assessments. Some percentage of workers were predicted to exceed the level of concern for all three compounds: 54% for azinphos methyl, 5% for acetamiprid, and 20% for emamectin benzoate. This finding has implications for pesticide risk assessment and offers an alternative procedure that may be more protective of those at the extremes of exposure than the current approach. © 2017 Society for Risk Analysis.

  20. Comparative assessment of plasmid DNA delivery by encapsulation ...

    African Journals Online (AJOL)

    Tropical Journal of Pharmaceutical Research January 2018; 17 (1): 1-10 ... Purpose: To compare the gene delivery effectiveness of plasmid DNA (pDNA) ..... Intramuscular delivery of DNA ... copolymeric system for gene delivery in complete.

  1. Comparative assessment of two agriculturally-influenced estuaries

    CSIR Research Space (South Africa)

    Lemley, DA

    2017-04-01

    Full Text Available This study compared the spatio-temporal dynamics in two agriculturally-influenced South African estuaries - Gamtoos and Sundays - to investigate how contrasting hydrological alterations influence physical, chemical and biological responses...

  2. Peer Review of Assessment Network: Supporting Comparability of Standards

    Science.gov (United States)

    Booth, Sara; Beckett, Jeff; Saunders, Cassandra

    2016-01-01

    Purpose: This paper aims to test the need in the Australian higher education (HE) sector for a national network for the peer review of assessment in response to the proposed HE standards framework and propose a sector-wide framework for calibrating and assuring achievement standards, both within and across disciplines, through the establishment of…

  3. Comparative assessment of knowledge, attitude and practice of ...

    African Journals Online (AJOL)

    This study was carried out to assess the level of knowledge, attitude and practice regarding cervical cancer and its screening among female clinical nursing students in Southern Nigeria. Methodology: ... There is need to adopt urgent and drastic intervention strategies to save our women from unnecessary death. Keywords: ...

  4. Comparative assessment of seller's staining test (SST) and direct ...

    African Journals Online (AJOL)

    the only standard method. Objective: This study was designed to assess the sensitivity and specificity of the SST in relation to the 'gold standard' dFAT in diagnosis of rabies in Nigeria. Methods: A total of 88 animal specimens submitted to the Rabies National Reference Laboratory, Nigeria were routinely tested for rabies by ...

  5. Comparative safety assessment of plant-derived foods

    NARCIS (Netherlands)

    Kok, E.J.; Keijer, J.; Kleter, G.A.; Kuiper, H.A.

    2008-01-01

    The second generation of genetically modified (GM) plants that are moving towards the market are characterized by modifications that may be more complex and traits that more often are to the benefit of the consumer. These developments will have implications for the safety assessment of the resulting

  6. Comparative analysis of different modalities of assessment of lower ...

    African Journals Online (AJOL)

    LEAD was assessed in all the patients using: 1. History of intermittent claudication using the Edinburgh Claudication Questionnaire. 2. Palpation of pedal pulses for diminished or absent dorsalis pedis and/or posterior tibial artery pulsations. 3. Ankle Brachial Index <0.9 in either leg, using hand-held Doppler ultrasonography

  7. Exploring functional contexts of symbiotic sustain within lichen-associated bacteria by comparative omics

    Science.gov (United States)

    Grube, Martin; Cernava, Tomislav; Soh, Jung; Fuchs, Stephan; Aschenbrenner, Ines; Lassek, Christian; Wegner, Uwe; Becher, Dörte; Riedel, Katharina; Sensen, Christoph W; Berg, Gabriele

    2015-01-01

    Symbioses represent a frequent and successful lifestyle on earth and lichens are one of their classic examples. Recently, bacterial communities were identified as stable, specific and structurally integrated partners of the lichen symbiosis, but their role has remained largely elusive in comparison to the well-known functions of the fungal and algal partners. We have explored the metabolic potentials of the microbiome using the lung lichen Lobaria pulmonaria as the model. Metagenomic and proteomic data were comparatively assessed and visualized by Voronoi treemaps. The study was complemented with molecular, microscopic and physiological assays. We have found that more than 800 bacterial species have the ability to contribute multiple aspects to the symbiotic system, including essential functions such as (i) nutrient supply, especially nitrogen, phosphorous and sulfur, (ii) resistance against biotic stress factors (that is, pathogen defense), (iii) resistance against abiotic factors, (iv) support of photosynthesis by provision of vitamin B12, (v) fungal and algal growth support by provision of hormones, (vi) detoxification of metabolites, and (vii) degradation of older parts of the lichen thallus. Our findings showed the potential of lichen-associated bacteria to interact with the fungal as well as algal partner to support health, growth and fitness of their hosts. We developed a model of the symbiosis depicting the functional multi-player network of the participants, and argue that the strategy of functional diversification in lichens supports the longevity and persistence of lichens under extreme and changing ecological conditions. PMID:25072413

  8. Scintigraphic assessment of liver function in patients requiring liver surgery

    NARCIS (Netherlands)

    Cieślak, K.P.

    2018-01-01

    This thesis addresses various aspects of assessment of liver function using a quantitative liver function test, 99mTc-mebrofenin hepatobiliary scintigraphy (HBS). HBS enables direct measurement of at least one of the liver’s true processes with minimal external interference and offers the

  9. Skype: a tool for functional assessment in orthopaedic research.

    LENUS (Irish Health Repository)

    Good, Daniel W

    2012-03-01

    Skype is a free program which enables PC users to make video calls to other users with Internet access. We carried out a prospective review of all acromioclavicular joint hook plates for lateral-third clavicle fractures over a five-year period. Functional assessment with Oxford and Constant shoulder scores were carried out using Skype and compared to outpatient review using the Bland-Altman method. Of 36 patients (mean age 36 years), 33 had a computer with a video camera, all 33 had Internet access and 22 were already users of Skype. In total 29 patients were happy to take part in Skype assessment (83%). In comparison with outpatient review, there was a mean difference in the Oxford score of -0.48 (95% confidence interval -0.84, -0.12); the mean difference for the Constant score was -0.68 (95% confidence interval -1.08, -0.29). These differences were not clinically significant, confirming that Skype can be used as an alternative to goniometry in this clinical setting. A survey showed that 93% of 29 patients surveyed preferred the use of Skype for follow-up, mainly due to the convenience and cost-saving involved. The study demonstrates the potential for this new technique in providing patients with more options for follow-up.

  10. A Comparison of Functional Behavioral Assessment and Functional Analysis Methodology among Students with Mild Disabilities

    Science.gov (United States)

    Lewis, Timothy J.; Mitchell, Barbara S.; Harvey, Kristin; Green, Ambra; McKenzie, Jennifer

    2015-01-01

    Functional behavioral assessment (FBA) and functional analyses (FA) are grounded in the applied behavior analysis principle that posits problem behavior is functionally related to the environment in which it occurs and is maintained by either providing access to reinforcing outcomes or allowing the individual to avoid or escape that which they…

  11. Parents Function and Behavioral Disorders in Children with and without Diurnal Voiding Dysfunction: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Parsa Yousefi

    2014-09-01

    Full Text Available Background: Diurnal voiding dysfunction is one of the most common causes of pediatric urology clinic admissions. It can cause behavioral problems for children and their parents. We lunch this study to compare the parents’ function and children’s behavior problem in pediatric patients suffering from diurnal voiding dysfunction referring Arak Amir Kabir hospital. Materials and Methods: To perform this case-control study, we recruit 116 children with diurnal voiding dysfunction and compared them with other 116 children non-affected children aged between 5 to 16 years old. The child behavior checklist (CBCL4/18 for children behavior assessment and Global Assessment of Functioning (GAF for the evaluation of their parent’s behavior was completed by the parents. Data was analyzed using ANOVA, qualitative variables and χ2 formula. Results: Among 116 patient with voiding dysfunction, 10 case (8.6% showed behavioral problem while this figure was 3 case (2.6% in the control group, denoting a significant difference (p=0.04. Moreover 20 children (17.2% in the case group and 9 children (7.8% in the control group had internalizing problem (p=0.02. Twenty two children (19% with voiding dysfunction and 8 children (6.9% in the healthy group had externalizing problem which was also a significant difference (p=0.01. As a significant difference (0.01, the parent’s average stress and behavior scores in case and control group were 3.65 and 3.76, respectively. Conclusion: The higher prevalence of behavioral problem in the children suffering from diurnal voiding dysfunction and their parent’s functional impairment highlights the importance of early parent’s intervention for early treatment and subsequently prevention of future behavioral problem in their sibling.

  12. A comparative assessment of chemical contaminant removal by ...

    African Journals Online (AJOL)

    This study was aimed at modifying the design of, constructing, evaluating and comparing chemical contaminant removal efficiency by, 3 household water treatment filters. The filters were: 1) biosand filter (BSF); 2) the ceramic candle filter (CCF); 3) bucket filter (BF). The filters were evaluated for their efficiency in removal of ...

  13. Assessment of protection and comparative advantage in rice ...

    African Journals Online (AJOL)

    The main analytical framework used was the Policy Analysis Matrix (PAM). The policy distortions were measured through Nominal Protection Coefficient (NPC) and Effective Protection Coefficient (EPC). Private Profitability Coefficient (PPC) was used to measure the comparative advantage a processor has in producing ...

  14. Comparative Assessment of Women Farmers' Status in Japan and ...

    African Journals Online (AJOL)

    The research compared the status of Japanese and Nigerian women farmers. The study was conducted in Sera Chuo, Hiroshima and Ohnan Chuo, Shimane prefecture, Chugoku region of Japan and Southwestern part of Nigeria covering three locations (Omi-Adio, Ijaye and Kila) within the suburban area of Ibadan ...

  15. How Many Cases? Assessing the Comparability of EU Judicial Datasets

    NARCIS (Netherlands)

    E.A. Ontanu (Elena); M Velicogna (Marco); F. Contini (Francesco)

    2017-01-01

    markdownabstractEfficiency is often considered a key component of any effective justice system, and a crucial drive for economic growth. A growing body of comparative studies explores how judicial reforms leading to a greater efficiency or effectiveness are positively correlated with economic growth

  16. Comparative assessment of plasmid DNA delivery by encapsulation ...

    African Journals Online (AJOL)

    Purpose: To compare the gene delivery effectiveness of plasmid DNA (pDNA) encapsulated within poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles with that adsorbed on PLGA nanoparticles. Methods: PLGA nanoparticles were prepared using solvent-evaporation method. To encapsulate pDNA within the particles, ...

  17. Cognitive functioning and behaviour of epileptic children in parents' assessment.

    Science.gov (United States)

    Talarska, Dorota; Steinborn, Barbara; Michalak, Michał

    2011-01-01

    Cognitive functioning and behaviour of chronically ill children are affected by many factors, including anxiety due to hospitalization, persistent symptoms of sickness and adverse side effects of medications. The aim of this work was to seek out parents' opinion concerning cognitive functioning and behaviour of children with epilepsy. The study comprised 156 children with epilepsy aged 7-18 and treated in the Department of Developmental Neurology at Karol Marcinkowski Poznan University of Medical Sciences and in an outpatient clinic. The research tool used was the questionnaire Quality of Life in Childhood Epilepsy (QOLCE) completed by parents. Assessment of cognitive functioning and behaviour was based on the analysis of the areas V (cognitive processes) and VII (behaviour). Parents assessed children's functioning in the areas of cognitive processes and behaviour at a similar level - 55 points. In the area of cognitive processes, concentration while performing some tasks and reading was assessed as the worst. A significant difference in caregivers' assessment was found according to age, frequency of seizures and duration of disease. In the area analysing the child's behaviour, parents indicated getting angry easily and not being upset by other people's opinions. The display of aggression towards others got the lowest number of comments. The children's functioning was assessed by parents as rather poor in both analysed areas. Parents of children treated with polytherapy noticed more difficulties in cognitive functioning and behaviour than parents of children treated with one medication.

  18. Reliability of the Hazelbaker Assessment Tool for Lingual Frenulum Function

    Directory of Open Access Journals (Sweden)

    James Jennifer P

    2006-03-01

    Full Text Available Abstract Background About 3% of infants are born with a tongue-tie which may lead to breastfeeding problems such as ineffective latch, painful attachment or poor weight gain. The Hazelbaker Assessment Tool for Lingual Frenulum Function (HATLFF has been developed to give a quantitative assessment of the tongue-tie and recommendation about frenotomy (release of the frenulum. The aim of this study was to assess the inter-rater reliability of the HATLFF. Methods Fifty-eight infants referred to the Breastfeeding Education and Support Services (BESS at The Royal Women's Hospital for assessment of tongue-tie and 25 control infants were assessed by two clinicians independently. Results The Appearance items received kappas between about 0.4 to 0.6, which represents "moderate" reliability. The first three Function items (lateralization, lift and extension of tongue had kappa values over 0.65 which indicates "substantial" agreement. The four Function items relating to infant sucking (spread, cupping, peristalsis and snapback received low kappa values with insignificant p values. There was 96% agreement between the two assessors on the recommendation for frenotomy (kappa 0.92, excellent agreement. The study found that the Function Score can be more simply assessed using only the first three function items (ie not scoring the sucking items, with a cut-off of ≤4 for recommendation of frenotomy. Conclusion We found that the HATLFF has a high reliability in a study of infants with tongue-tie and control infants

  19. Assessment of recovery in older patients hospitalized with different diagnoses and functional levels, evaluated with and without geriatric assessment.

    Science.gov (United States)

    Abrahamsen, Jenny Foss; Haugland, Cathrine; Ranhoff, Anette Hylen

    2016-01-01

    The objective of the present study was to investigate 1) the role of different admission diagnoses and 2) the degree of functional loss, on the rate of recovery of older patients after acute hospitalization. Furthermore, to compare the predictive value of simple assessments that can be carried out in a hospital lacking geriatric service, with assessments including geriatric screening tests. Prospective, observational cohort study, including 961community dwelling patients aged ≥ 70 years, transferred from medical, cardiac, pulmonary and orthopedic acute hospital departments to intermediate care in nursing home. Functional assessment with Barthel index (BI) was performed at admission to the nursing home and further geriatric assessment tests was performed during the first week. Logistic regression models with and without geriatric assessment were compared concerning the patients having 1) slow recovery (nursing home stay up to 2 months before return home) or, 2) poor recovery (dead or still in nursing home at 2 months). Slow recovery was independently associated with a diagnosis of non-vertebral fracture, BI subgroups 50-79 and model including geriatric assessment, also with cognitive impairment. Poor recovery was more complex, and independently associated both with BI model, cognitive impairment. Geriatric assessment is optimal for determining the recovery potential of older patients after acute hospitalization. As some hospitals lack geriatric services and ability to perform geriatric screening tests, a simpler assessment based on admission diagnoses and ADL function (BI), gives good information regarding the possible rehabilitation time and possibility to return home.

  20. Measurement Properties of Indirect Assessment Methods for Functional Behavioral Assessment: A Review of Research

    Science.gov (United States)

    Floyd, Randy G.; Phaneuf, Robin L.; Wilczynski, Susan M.

    2005-01-01

    Indirect assessment instruments used during functional behavioral assessment, such as rating scales, interviews, and self-report instruments, represent the least intrusive techniques for acquiring information about the function of problem behavior. This article provides criteria for examining the measurement properties of these instruments…

  1. A bi-level environmental impact assessment framework for comparing construction and demolition waste management strategies.

    Science.gov (United States)

    Yazdanbakhsh, Ardavan

    2018-04-27

    Several pioneering life cycle assessment (LCA) studies have been conducted in the past to assess the environmental impact of specific methods for managing mineral construction and demolition waste (MCDW), such as recycling the waste for use in concrete. Those studies focus on comparing the use of recycled MCDW and that of virgin components to produce materials or systems that serve specified functions. Often, the approaches adopted by the studies do not account for the potential environmental consequence of avoiding the existing or alternative waste management practices. The present work focuses on how product systems need to be defined in recycling LCA studies and what processes need to be within the system boundaries. A bi-level LCA framework is presented for modelling alternative waste management approaches in which the impacts are measured and compared at two scales of strategy and decision-making. Different functional units are defined for each level, all of which correspond to the same flow of MCDW in a cascade of product systems. For the sole purpose of demonstrating how the framework is implemented an illustrative example is presented, based on real data and a number of simplifying assumptions, which compares the impacts of a number of potential MCDW management strategies in New York City. Copyright © 2018 Elsevier Ltd. All rights reserved.

  2. Comparative study on the welded structure fatigue strength assessment method

    Science.gov (United States)

    Hu, Tao

    2018-04-01

    Due to the welding structure is widely applied in various industries, especially the pressure container, motorcycle, automobile, aviation, ship industry, such as large crane steel structure, so for welded structure fatigue strength evaluation is particularly important. For welded structure fatigue strength evaluation method mainly has four kinds of, the more from the use of two kinds of welded structure fatigue strength evaluation method, namely the nominal stress method and the hot spot stress evaluation method, comparing from its principle, calculation method for the process analysis and research, compare the similarities and the advantages and disadvantages, the analysis of practical engineering problems to provide the reference for every profession and trade, as well as the future welded structure fatigue strength and life evaluation method put forward outlook.

  3. Comparative assessment of PV plant performance models considering climate effects

    DEFF Research Database (Denmark)

    Tina, Giuseppe; Ventura, Cristina; Sera, Dezso

    2017-01-01

    . The methodological approach is based on comparative tests of the analyzed models applied to two PV plants installed respectively in north of Denmark (Aalborg) and in the south of Italy (Agrigento). The different ambient, operating and installation conditions allow to understand how these factors impact the precision...... the performance of the studied PV plants with others, the efficiency of the systems has been estimated by both conventional Performance Ratio and Corrected Performance Ratio...

  4. Assessing physical function and physical activity in patients with CKD.

    Science.gov (United States)

    Painter, Patricia; Marcus, Robin L

    2013-05-01

    Patients with CKD are characterized by low levels of physical functioning, which, along with low physical activity, predict poor outcomes in those treated with dialysis. The hallmark of clinical care in geriatric practice and geriatric research is the orientation to and assessment of physical function and functional limitations. Although there is increasing interest in physical function and physical activity in patients with CKD, the nephrology field has not focused on this aspect of care. This paper provides an in-depth review of the measurement of physical function and physical activity. It focuses on physiologic impairments and physical performance limitations (impaired mobility and functional limitations). The review is based on established frameworks of physical impairment and functional limitations that have guided research in physical function in the aging population. Definitions and measures for physiologic impairments, physical performance limitations, self-reported function, and physical activity are presented. On the basis of the information presented, recommendations for incorporating routine assessment of physical function and encouragement for physical activity in clinical care are provided.

  5. Comparative assessment of ceramic media for drinking water biofiltration.

    Science.gov (United States)

    Sharma, Dikshant; Taylor-Edmonds, Liz; Andrews, Robert C

    2018-01-01

    Media type is a critical design consideration when implementing biofiltration for drinking water treatment. Granular activated carbon (GAC) has been shown to provide superior performance when compared to a wide range of media types, largely due to its higher surface area. Engineered ceramic media is an attractive alternative to GAC as it has a similar surface area but at a lower cost. This pilot-scale biofiltration study compared the performance of GAC, anthracite and two different effective sizes of ceramic (CER) media (1.0 mm and 1.2 mm), in terms of dissolved organic carbon (DOC), head loss, turbidity, and disinfection by-product formation potential (DBPFP). Biological acclimation was monitored using adenosine tri-phosphate (ATP) measurements; biomass was further examined using laccase and esterase enzyme activity assays. When compared to other media types examined, biological GAC had higher (p > 0.05) removals of DOC (9.8 ± 3.8%), trihalomethane formation potential (THMFP, 26.3 ± 10.2%), and haloacetic acid formation potential (HAAFP, 27.2 ± 14.0%). CER media required 6-7 months to biologically acclimate, while filters containing GAC and anthracite were biologically active (>100 ng of ATP/g media) following 30-45 days of operation. Once acclimated, ATP values of 243 and 208 ng/g attained for CER 1.0 and 1.2, respectively, were statistically comparable to GAC (244 ng/g) and higher than anthracite (110 ng/g), however this did not translate into greater organics removal. Esterase and laccase enzyme kinetics were highest for GAC, while CER was shown to have greater biodegradation potential than anthracite. The four media types attained similar turbidity reduction (p > 0.05), however ceramic media filters were observed to have run times which were 1.5-2.3 times longer when compared to anthracite, which could represent potential cost savings in terms of energy for pumping and backwash requirements. Overall, ceramic media was shown to be a potential

  6. Questionnaire-based assessment of executive functioning: Case studies.

    Science.gov (United States)

    Kronenberger, William G; Castellanos, Irina; Pisoni, David B

    2018-01-01

    Delays in the development of executive functioning skills are frequently observed in pediatric neuropsychology populations and can have a broad and significant impact on quality of life. As a result, assessment of executive functioning is often relevant for the development of formulations and recommendations in pediatric neuropsychology clinical work. Questionnaire-based measures of executive functioning behaviors in everyday life have unique advantages and complement traditional neuropsychological measures of executive functioning. Two case studies of children with spina bifida are presented to illustrate the clinical use of a new questionnaire measure of executive and learning-related functioning, the Learning, Executive, and Attention Functioning Scale (LEAF). The LEAF emphasizes clinical utility in assessment by incorporating four characteristics: brevity in administration, breadth of additional relevant content, efficiency of scoring and interpretation, and ease of availability for use. LEAF results were consistent with another executive functioning checklist in documenting everyday behavior problems related to working memory, planning, and organization while offering additional breadth of assessment of domains such as attention, processing speed, and novel problem-solving. These case study results demonstrate the clinical utility of questionnaire-based measurement of executive functioning in pediatric neuropsychology and provide a new measure for accomplishing this goal.

  7. Comparative assessment of circular economy development in China's four megacities

    DEFF Research Database (Denmark)

    Guo, Bin; Geng, Yong; Ren, Jingzheng

    2017-01-01

    Resources scarcity and environmental pollution in China negatively influence the country's sustainable development. Circular Economy (CE), which established on the basis of “3R principals”, was adopted by the Chinese authorities as a national development strategy to reduce resource consumption...... and mitigate environmental pollution. After more than ten years’ implementation of CE strategy, it is of vital importance to investigate the progresses and current status of CE development in China, especially in those China's megacities from both spatial and temporal perspectives, so as to identify...... the barriers of local CE development in megacities. To achieve such an objective, this study assesses the CE development in China's four megacities during the last ten years by using one unified indicator system. Results indicate that significant disparities exist among China's four megacities regarding both...

  8. Comparative recreational assessment of Karaganda city public green spaces

    Science.gov (United States)

    Akylbekova, I. S.; Zengina, T. Yu

    2018-01-01

    This article represents evaluation of recreation environment on the territory of the large industrial city of Karaganda, located in the dry steppe zone of Central Kazakhstan. A comparison of quantitative and qualitative indicators, level of recreational attractiveness and providing the citizens with public green spaces, allowed to make a more complete characterization the urban recreation places and to identify the city districts, which require prioritized fundraising for development of existing parks and public gardens, and for creation of new territories of recreational purpose. Based on the results of conducted expert assessment and sociological survey of visitors, the main problems of urban green areas were identified and also the most high-demand trends and practical recommendations for their improvement and further use were proposed.

  9. Comparative Assessment of Advanced Gay Hydrate Production Methods

    Energy Technology Data Exchange (ETDEWEB)

    M. D. White; B. P. McGrail; S. K. Wurstner

    2009-06-30

    Displacing natural gas and petroleum with carbon dioxide is a proven technology for producing conventional geologic hydrocarbon reservoirs, and producing additional yields from abandoned or partially produced petroleum reservoirs. Extending this concept to natural gas hydrate production offers the potential to enhance gas hydrate recovery with concomitant permanent geologic sequestration. Numerical simulation was used to assess a suite of carbon dioxide injection techniques for producing gas hydrates from a variety of geologic deposit types. Secondary hydrate formation was found to inhibit contact of the injected CO{sub 2} regardless of injectate phase state, thus diminishing the exchange rate due to pore clogging and hydrate zone bypass of the injected fluids. Additional work is needed to develop methods of artificially introducing high-permeability pathways in gas hydrate zones if injection of CO{sub 2} in either gas, liquid, or micro-emulsion form is to be more effective in enhancing gas hydrate production rates.

  10. A Comparative Study on Emerging Electric Vehicle Technology Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Ford, Jonathan [Sentech, Inc.; Khowailed, Gannate [Sentech, Inc.; Blackburn, Julia [Sentech, Inc.; Sikes, Karen [Sentech, Inc.

    2011-03-01

    Numerous organizations have published reports in recent years that investigate the ever changing world of electric vehicle (EV) technologies and their potential effects on society. Specifically, projections have been made on greenhouse gas (GHG) emissions associated with these vehicles and how they compare to conventional vehicles or hybrid electric vehicles (HEVs). Similar projections have been made on the volumes of oil that these vehicles can displace by consuming large amounts of grid electricity instead of petroleum-based fuels. Finally, the projected rate that these new vehicle fleets will enter the market varies significantly among organizations. New ideas, technologies, and possibilities are introduced often, and projected values are likely to be refined as industry announcements continue to be made. As a result, over time, a multitude of projections for GHG emissions, oil displacement, and market penetration associated with various EV technologies has resulted in a wide range of possible future outcomes. This leaves the reader with two key questions: (1) Why does such a collective range in projected values exist in these reports? (2) What assumptions have the greatest impact on the outcomes presented in these reports? Since it is impractical for an average reader to review and interpret all the various vehicle technology reports published to date, Sentech Inc. and the Oak Ridge National Laboratory have conducted a comparative study to make these interpretations. The primary objective of this comparative study is to present a snapshot of all major projections made on GHG emissions, oil displacement, or market penetration rates of EV technologies. From the extensive data found in relevant publications, the key assumptions that drive each report's analysis are identified and 'apples-to-apples' comparisons between all major report conclusions are attempted. The general approach that was taken in this comparative study is comprised of six primary

  11. Comparative safety assessment of surface versus submarine plutonium shipments

    International Nuclear Information System (INIS)

    Knepper, D.S.; Feltus, M.A.

    1993-01-01

    The recent shipment of plutonium from France to Japan aboard the freighter Akatsuki Maru touched off protests from environmental and antinuclear organizations. These protests arose from the fear of an accidental sinking of the vessel that would release its cargo to the sea, as well as the threat of a terrorist nation highjacking the ship for its cargo to produce atomic weapons. The sinking of a merchant ship is not uncommon, as illustrated by the famous losses of the tankers Amoco Cadiz and Exxon Valdez. The highjacking of a lightly armed freighter such as the Akatsuki Maru is possible and would not be unduly difficult for a well-equipped terrorist nation. The combined threats of weapons proliferation and environmental damage arising from the diversion or destruction of a sea vessel carrying plutonium will continue to abound as the reprocessing of spent nuclear fuel increases. An alternate method for the transportation with reduced risks of both diversion and destruction needs to be developed. The shipment aboard the Akatsuki Maru was originally proposed to be flown from France to Japan over the continental United States. This proposal was rejected by the Reagan administration in 1988. A third alternative to the current ideas of air transport and surface transport is subsurface transport. This research project investigates the transportation of plutonium by submarine and compares it to the current method of transportation by freighter. This analysis involves a study of the military threat to a submarine by a terrorist nation and comparable threat to a surface vessel. To study the nonmilitary aspects of plutonium shipping, a fault-tree evaluation is performed for transportation by submarine and compared with the current risk analysis performed for surface vessels

  12. A comparative assessment of waste incinerators in the UK

    Energy Technology Data Exchange (ETDEWEB)

    Nixon, J.D., E-mail: j.nixon@kingston.ac.uk [Sustainable Environment Research Group, School of Engineering and Applied Science, Aston University, Aston Triangle, Birmingham B4 7ET (United Kingdom); Wright, D.G.; Dey, P.K. [Aston Business School, Aston University, Aston Triangle, Birmingham B4 7ET (United Kingdom); Ghosh, S.K. [Mechanical Engineering Department, Centre for Quality Management System, Jadavpur University, Kolkata 700 032 (India); Davies, P.A. [Sustainable Environment Research Group, School of Engineering and Applied Science, Aston University, Aston Triangle, Birmingham B4 7ET (United Kingdom)

    2013-11-15

    Highlights: • We evaluate operational municipal solid waste incinerators in the UK. • The supply chain of four case study plants are examined and compared in detail. • Technical, financial and operational data has been gathered for the four plants. • We suggest the best business practices for waste incinerators. • Appropriate strategy choices are the major difficulties for waste to energy plants. - Abstract: The uptake in Europe of Energy from Waste (EfW) incinerator plants has increased rapidly in recent years. In the UK, 25 municipal waste incinerators with energy recovery are now in operation; however, their waste supply chains and business practices vary significantly. With over a hundred more plant developments being considered it is important to establish best business practices for ensuring efficient environmental and operational performance. By reviewing the 25 plants we identify four suitable case study plants to compare technologies (moving grate, fluidised bed and rotary kiln), plant economics and operations. Using data collected from annual reports and through interviews and site visits we provide recommendations for improving the supply chain for waste incinerators and highlight the current issues and challenges faced by the industry. We find that plants using moving grate have a high availability of 87–92%. However, compared to the fluidised bed and rotary kiln, quantities of bottom ash and emissions of hydrogen chloride and carbon monoxide are high. The uptake of integrated recycling practices, combined heat and power, and post incineration non-ferrous metal collections needs to be increased among EfW incinerators in the UK. We conclude that one of the major difficulties encountered by waste facilities is the appropriate selection of technology, capacity, site, waste suppliers and heat consumers. This study will be of particular value to EfW plant developers, government authorities and researchers working within the sector of waste

  13. A comparative assessment of waste incinerators in the UK

    International Nuclear Information System (INIS)

    Nixon, J.D.; Wright, D.G.; Dey, P.K.; Ghosh, S.K.; Davies, P.A.

    2013-01-01

    Highlights: • We evaluate operational municipal solid waste incinerators in the UK. • The supply chain of four case study plants are examined and compared in detail. • Technical, financial and operational data has been gathered for the four plants. • We suggest the best business practices for waste incinerators. • Appropriate strategy choices are the major difficulties for waste to energy plants. - Abstract: The uptake in Europe of Energy from Waste (EfW) incinerator plants has increased rapidly in recent years. In the UK, 25 municipal waste incinerators with energy recovery are now in operation; however, their waste supply chains and business practices vary significantly. With over a hundred more plant developments being considered it is important to establish best business practices for ensuring efficient environmental and operational performance. By reviewing the 25 plants we identify four suitable case study plants to compare technologies (moving grate, fluidised bed and rotary kiln), plant economics and operations. Using data collected from annual reports and through interviews and site visits we provide recommendations for improving the supply chain for waste incinerators and highlight the current issues and challenges faced by the industry. We find that plants using moving grate have a high availability of 87–92%. However, compared to the fluidised bed and rotary kiln, quantities of bottom ash and emissions of hydrogen chloride and carbon monoxide are high. The uptake of integrated recycling practices, combined heat and power, and post incineration non-ferrous metal collections needs to be increased among EfW incinerators in the UK. We conclude that one of the major difficulties encountered by waste facilities is the appropriate selection of technology, capacity, site, waste suppliers and heat consumers. This study will be of particular value to EfW plant developers, government authorities and researchers working within the sector of waste

  14. A comparative assessment of efficacy of three anticoagulant rodenticides.

    Science.gov (United States)

    Renapurkar, D M

    1982-01-01

    Results are presented of feeding tests carried out with three common anticoagulant rodenticides viz., coumatetralyl, fumarin and warfarin on three common species of commensal rodents i.e., Rattus rattus, Rattus norvegicus and Bandicota bengalensis. All three species of rodents were susceptible to anticoagulant rodenticides. However, the action of these compounds in B. bengalensis was comparatively slow. Coumatetralyl was found to be the most effective rodenticide followed by fumarin and warfarin. Liquid baits of these compounds are more effective in comparison to food baits.

  15. Development of bilingual tools to assess functional health patterns.

    Science.gov (United States)

    Krozy, R E; McCarthy, N C

    1999-01-01

    The theory and process of developing bilingual assessment tools based on Gordon's 11 functional health patterns. To facilitate assessing the individual, family, and community in a student clinical practicum in a Spanish-speaking country. Multiple family and community health promotion theories; translation theories, Gordon's Manual of Nursing Diagnosis (1982); translation/back-translation involving Ecuadorian faculty and students; student community assessments; faculty and staff workshops in Ecuador. Bilingual, culturally sensitive health assessment tools facilitate history taking, establish nursing diagnoses and interventions, and promote mutual learning. These outcomes demonstrate potential application to other systems in the international nursing community.

  16. Objective Integrated Assessment of Functional Outcomes in Reduction Mammaplasty

    Science.gov (United States)

    Passaro, Ilaria; Malovini, Alberto; Faga, Angela; Toffola, Elena Dalla

    2013-01-01

    Background: The aim of our study was an objective integrated assessment of the functional outcomes of reduction mammaplasty. Methods: The study involved 17 women undergoing reduction mammaplasty from March 2009 to June 2011. Each patient was assessed before surgery and 2 months postoperatively with the original association of 4 subjective and objective assessment methods: a physiatric clinical examination, the Roland Morris Disability Questionnaire, the Berg Balance Scale, and a static force platform analysis. Results: All of the tests proved multiple statistically significant associated outcomes demonstrating a significant improvement in the functional status following reduction mammaplasty. Surgical correction of breast hypertrophy could achieve both spinal pain relief and recovery of performance status in everyday life tasks, owing to a muscular postural functional rearrangement with a consistent antigravity muscle activity sparing. Pain reduction in turn could reduce the antalgic stiffness and improved the spinal range of motion. In our sample, the improvement of the spinal range of motion in flexion matched a similar improvement in extension. Recovery of a more favorable postural pattern with reduction of the anterior imbalance was demonstrated by the static force stabilometry. Therefore, postoperatively, all of our patients narrowed the gap between the actual body barycenter and the ideal one. The static force platform assessment also consistently confirmed the effectiveness of an accurate clinical examination of functional impairment from breast hypertrophy. Conclusions: The static force platform assessment might help the clinician to support the diagnosis of functional impairment from a breast hypertrophy with objectively based data. PMID:25289256

  17. A comparative assessment of waste incinerators in the UK.

    Science.gov (United States)

    Nixon, J D; Wright, D G; Dey, P K; Ghosh, S K; Davies, P A

    2013-11-01

    The uptake in Europe of Energy from Waste (EfW) incinerator plants has increased rapidly in recent years. In the UK, 25 municipal waste incinerators with energy recovery are now in operation; however, their waste supply chains and business practices vary significantly. With over a hundred more plant developments being considered it is important to establish best business practices for ensuring efficient environmental and operational performance. By reviewing the 25 plants we identify four suitable case study plants to compare technologies (moving grate, fluidised bed and rotary kiln), plant economics and operations. Using data collected from annual reports and through interviews and site visits we provide recommendations for improving the supply chain for waste incinerators and highlight the current issues and challenges faced by the industry. We find that plants using moving grate have a high availability of 87-92%. However, compared to the fluidised bed and rotary kiln, quantities of bottom ash and emissions of hydrogen chloride and carbon monoxide are high. The uptake of integrated recycling practices, combined heat and power, and post incineration non-ferrous metal collections needs to be increased among EfW incinerators in the UK. We conclude that one of the major difficulties encountered by waste facilities is the appropriate selection of technology, capacity, site, waste suppliers and heat consumers. This study will be of particular value to EfW plant developers, government authorities and researchers working within the sector of waste management. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Activities in dementia care: A comparative assessment of activity types.

    Science.gov (United States)

    Lokon, Elizabeth; Sauer, Philip E; Li, Yue

    2016-12-05

    This exploratory study compares the impact of five activity types on the well-being of institutionalized people with dementia: the intergenerational art program Opening Minds through Art, art and music therapies, creative activities, non-creative activities, and no activities at all. We validated the Scripps Modified Greater Cincinnati Chapter Well-Being Observational Tool, and used that instrument to systematically observe N = 67 people with dementia as they participated in different activity types. People with dementia showed the highest well-being scores during Opening Minds through Art compared to all other activities. No significant well-being differences were found between creative activities led by licensed art/music therapist versus regular activity staff. Furthermore, no significant well-being differences were found between creative and non-creative activities that were both led by regular activity staff. Overall, people with dementia benefit from participating in activities, regardless of the type (creative or non-creative), or who conducts them (licensed therapists or activity staff). However, in order for people with dementia to reach significantly high levels of overall well-being, we recommend that activities are specifically designed for people with dementia and incorporate a 1:1 ratio between people with dementia and well-trained volunteers/staff members. © The Author(s) 2016.

  19. Twelve metropolitan carbon footprints. A preliminary comparative global assessment

    International Nuclear Information System (INIS)

    Sovacool, Benjamin K.; Brown, Marilyn A.

    2010-01-01

    A dearth of available data on carbon emissions and comparative analysis between metropolitan areas make it difficult to confirm or refute best practices and policies. To help provide benchmarks and expand our understanding of urban centers and climate change, this article offers a preliminary comparison of the carbon footprints of 12 metropolitan areas. It does this by examining emissions related to vehicles, energy used in buildings, industry, agriculture, and waste. The carbon emissions from these sources - discussed here as the metro area's partial carbon footprint - provide a foundation for identifying the pricing, land use, help metropolitan areas throughout the world respond to climate change. The article begins by exploring a sample of the existing literature on urban morphology and climate change and explaining the methodology used to calculate each area's carbon footprint. The article then depicts the specific carbon footprints for Beijing, Jakarta, London, Los Angeles, Manila, Mexico City, New Delhi, New York, Sao Paulo, Seoul, Singapore, and Tokyo and compares these to respective national averages. It concludes by offering suggestions for how city planners and policymakers can reduce the carbon footprint of these and possibly other large urban areas. (author)

  20. Intraoperative Neural Response Telemetry and Neural Recovery Function: a Comparative Study between Adults and Children

    Directory of Open Access Journals (Sweden)

    Carvalho, Bettina

    2014-04-01

    Full Text Available Introduction Neural response telemetry (NRT is a method of capturing the action potential of the distal portion of the auditory nerve in cochlear implant (CI users, using the CI itself to elicit and record the answers. In addition, it can also measure the recovery function of the auditory nerve (REC, that is, the refractory properties of the nerve. It is not clear in the literature whether the responses from adults are the same as those from children. Objective To compare the results of NRT and REC between adults and children undergoing CI surgery. Methods Cross-sectional, descriptive, and retrospective study of the results of NRT and REC for patients undergoing IC at our service. The NRT is assessed by the level of amplitude (microvolts and REC as a function of three parameters: A (saturation level, in microvolts, t0 (absolute refractory period, in seconds, and tau (curve of the model function, measured in three electrodes (apical, medial, and basal. Results Fifty-two patients were evaluated with intraoperative NRT (26 adults and 26 children, and 24 with REC (12 adults and 12 children. No statistically significant difference was found between intraoperative responses of adults and children for NRT or for REC's three parameters, except for parameter A of the basal electrode. Conclusion The results of intraoperative NRT and REC were not different between adults and children, except for parameter A of the basal electrode.

  1. Assessing and comparing information security in swiss hospitals.

    Science.gov (United States)

    Landolt, Sarah; Hirschel, Jürg; Schlienger, Thomas; Businger, Walter; Zbinden, Alex M

    2012-11-07

    Availability of information in hospitals is an important prerequisite for good service. Significant resources have been invested to improve the availability of information, but it is also vital that the security of this information can be guaranteed. The goal of this study was to assess information security in hospitals through a questionnaire based on the International Organization for Standardization (ISO) and the International Electrotechnical Commission (IEC) standard ISO/IEC 27002, evaluating Information technology - Security techniques - Code of practice for information-security management, with a special focus on the effect of the hospitals' size and type. The survey, set up as a cross-sectional study, was conducted in January 2011. The chief information officers (CIOs) of 112 hospitals in German-speaking Switzerland were invited to participate. The online questionnaire was designed to be fast and easy to complete to maximize participation. To group the analyzed controls of the ISO/IEC standard 27002 in a meaningful way, a factor analysis was performed. A linear score from 0 (not implemented) to 3 (fully implemented) was introduced. The scores of the hospitals were then analyzed for significant differences in any of the factors with respect to size and type of hospital. The participating hospitals were offered a benchmark report about their status. The 51 participating hospitals had an average score of 51.1% (range 30.6% - 81.9%) out of a possible 100% where all items in the questionnaire were fully implemented. Room for improvement could be identified, especially for the factors covering "process and quality management" (average score 1.3 ± 0.8 out of a maximum of 3) and "organization and risk management" (average score 1.3 ± 0.7 out of a maximum of 3). Private hospitals scored significantly higher than university hospitals in the implementation of "security zones" and "backup" (P = .008). Half (50.00%, 8588/17,177) of all assessed hospital beds

  2. Stress views in the comparative assessment of spondylolytic spondylolithesis

    International Nuclear Information System (INIS)

    Kaelebo, P.; Goeteborg Univ.; Kadziolka, R.; Swaerd, L.; Zachrisson, B.E.

    1989-01-01

    Patients with spondylolytic spondylolisthesis were examined in six different positions to detect segmental instability. The amount of displacement was determined on lateral spot radiographs, taken in recumbent, standing, flexion, extension, axial compression, and traction positions in each patient. An error analysis was also performed. Examination in axial compression - traction was found to be a significantly better method for detection of segmental instability compared with standing - recumbent, or flexion - extension radiographs. In addition, the compression - traction method exhibited a higher sensitivity for identification of instability (73 %) than standing - recumbent (33 %) or flexion - extension (20 %) views. The total error in the determination was small, ± 2.5 % (95 % CL), providing a careful and controlled technique was used. (orig.)

  3. Stakeholder assessment of comparative effectiveness research needs for Medicaid populations

    Science.gov (United States)

    Fischer, Michael A; Allen-Coleman, Cora; Farrell, Stephen F; Schneeweiss, Sebastian

    2015-01-01

    Patients, providers and policy-makers rely heavily on comparative effectiveness research (CER) when making complex, real-world medical decisions. In particular, Medicaid providers and policy-makers face unique challenges in decision-making because their program cares for traditionally underserved populations, especially children, pregnant women and people with mental illness. Because these patient populations have generally been underrepresented in research discussions, CER questions for these groups may be understudied. To address this problem, the Agency for Healthcare Research and Quality commissioned our team to work with Medicaid Medical Directors and other stakeholders to identify relevant CER questions. Through an iterative process of topic identification and refinement, we developed relevant, feasible and actionable questions based on issues affecting Medicaid programs nationwide. We describe challenges and limitations and provide recommendations for future stakeholder engagement. PMID:26388438

  4. Comparative life cycle assessment of standard and green roofs.

    Science.gov (United States)

    Saiz, Susana; Kennedy, Christopher; Bass, Brad; Pressnail, Kim

    2006-07-01

    Life cycle assessment (LCA) is used to evaluate the benefits, primarily from reduced energy consumption, resulting from the addition of a green roof to an eight story residential building in Madrid. Building energy use is simulated and a bottom-up LCA is conducted assuming a 50 year building life. The key property of a green roof is its low solar absorptance, which causes lower surface temperature, thereby reducing the heat flux through the roof. Savings in annual energy use are just over 1%, but summer cooling load is reduced by over 6% and reductions in peak hour cooling load in the upper floors reach 25%. By replacing the common flat roof with a green roof, environmental impacts are reduced by between 1.0 and 5.3%. Similar reductions might be achieved by using a white roof with additional insulation for winter, but more substantial reductions are achieved if common use of green roofs leads to reductions in the urban heat island.

  5. Assessing Moroccan University Students’ English Learning Motivation: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Otmane Omari

    2018-02-01

    Full Text Available This study seeks to survey whether students are motivated to learn English or not and to evaluate the differences within and between three most known universities in Morocco, involving a private one, in terms of students’ English learning motivation. Moreover, factors that make a student more motivated to learn English were investigated. This study examines motivation of university students according to their institution, gender, and other variables. Assessment of university students’ motivation was by scores on items from the Academic Motivation Scale. The sample consisted of 329 undergraduate students from three different Moroccan universities. The most important finding was that participants in general are quite motivated to learn English with a score of (M = 3.80 with regard to the overall score using a 5-point Likert scale, and a higher level of introjected extrinsic motivation (M = 4.11, which means that they do such tasks because they are supposed or asked to do them. Moreover, factors such as how students consider university, their location during the academic year, and their decision behind choosing to go to university were found to affect students’ motivation.

  6. Comparative assessment of licensing processes of uranium mines in Brazil

    International Nuclear Information System (INIS)

    Silva, K.M.; Menezes, R.M.; Mezrahi, A.

    2002-01-01

    Commercial operation of uranium mining and milling started in Brazil, at the Pocos de Caldas Unit, State of Minas Gerais, in 1982. The Pocos de Caldas Unit was licensed by the Brazilian Regulatory Body (CNEN) and its is now in the decommissioning process. In 2000, a new mining and milling installation, the Caetite Unit, located in State of Bahia, started operation. This paper will discuss how Brazilian Nuclear Energy Commission is licensing the Caetite Unit based on the lessons learned from the Pocos de Caldas Unit. The objective is to draw attention to the importance of the safety assessment for a new unit, specially considering that some wrong decisions were taken for the Pocos de Caldas unit. These decisions lead to less effective long term solutions to protect the environment. Notwithstanding the differences between the two units, it is of great value to use the acquired experience to avoid or minimize the short, medium and long term impacts to the environment and population in the new operation. (author)

  7. Functional Resilience against Climate-Driven Extinctions - Comparing the Functional Diversity of European and North American Tree Floras.

    Directory of Open Access Journals (Sweden)

    Mario Liebergesell

    Full Text Available Future global change scenarios predict a dramatic loss of biodiversity for many regions in the world, potentially reducing the resistance and resilience of ecosystem functions. Once before, during Plio-Pleistocene glaciations, harsher climatic conditions in Europe as compared to North America led to a more depauperate tree flora. Here we hypothesize that this climate driven species loss has also reduced functional diversity in Europe as compared to North America. We used variation in 26 traits for 154 North American and 66 European tree species and grid-based co-occurrences derived from distribution maps to compare functional diversity patterns of the two continents. First, we identified similar regions with respect to contemporary climate in the temperate zone of North America and Europe. Second, we compared the functional diversity of both continents and for the climatically similar sub-regions using the functional dispersion-index (FDis and the functional richness index (FRic. Third, we accounted in these comparisons for grid-scale differences in species richness, and, fourth, investigated the associated trait spaces using dimensionality reduction. For gymnosperms we find similar functional diversity on both continents, whereas for angiosperms functional diversity is significantly greater in Europe than in North America. These results are consistent across different scales, for climatically similar regions and considering species richness patterns. We decomposed these differences in trait space occupation into differences in functional diversity vs. differences in functional identity. We show that climate-driven species loss on a continental scale might be decoupled from or at least not linearly related to changes in functional diversity. This might be important when analyzing the effects of climate-driven biodiversity change on ecosystem functioning.

  8. Comparing the loss of functional independence of older adults in the U.S. and China.

    Science.gov (United States)

    Fong, Joelle H; Feng, Jun

    2018-01-01

    Functional loss among older adults is known to follow a hierarchical sequence, but little is known about whether such sequences differ across socio-cultural contexts. The aim of this study is to construct activities of daily livings (ADL) scales for oldest-old adults in the United States and China so as to compare their functional loss sequences. We use data from the Asset and Health Dynamics of the Oldest Old (n=1607) and Chinese Longitudinal Healthy Longevity Survey (n=5570) for years 1998-2008. ADL items are calibrated within a scale using the Rasch measurement model. Rasch scores are averaged across survey waves to identify the ADL loss sequence for each study population. We also assess scale stability over measurement periods. Factor analyses confirm that the ADL items in each study population can be combined meaningfully to form a hierarchical sequence. Internal consistency assessed by Cronbach's alpha is high (0.81 to 0.95). We find that bathing is the first activity that both older Americans and Chinese have difficulty with, while eating is the last activity. There are, however, differences in the rank order for toileting (ranked more challenging in the Chinese sample) and dressing (ranked more challenging in the U.S. sample). Item orderings are stable over time. The results highlight the relative importance of bathing in the functional loss sequence for older adults, regardless of socio-cultural context. Health interventions are needed to address deficits in the bathroom environment, especially in developing countries like China. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Comparative assessment of antioxidant activity of chicory products

    Directory of Open Access Journals (Sweden)

    Z. A. Badretdinova

    2016-01-01

    Full Text Available There are various methods for determining the antioxidant activity. They are differing by the source of oxidation, oxidized compounds and methods for the measurement of oxidized compounds. Methods for determination of antioxidant activity provide a wide range of results, so the evaluation of the antioxidant activity should be carried out in several ways, and the results should be interpreted with caution. In assessing antioxidant capacity is necessary to consider not only the nature and content of the reducing agent in the test facility, but also the possibility of their mutual influence. The objects of research in this research work were Instant chicory (Leroux, Fried chicory (Leroux, Instant chicory (LLC Favorit, Instant chicory (LLC SlavKofe, Instant chicory with hawthorn (Iceberg Ltd and K, Instant chicory (LLC Flagistom, Instant chicory (Ltd. Around the World, Instant chicory (LLC Beta +, Chicory flour (Leroux, Chicory flour. Antioxidant activity of the products of chicory determined by spectrophotometric (using adrenaline and 2,2 – diphenyl- 1-picrylhydrazyl, and amperometric methods. These results indicate that chicory products possess antioxidant activity but not give fully correlated with each other results. The highest antioxidant activity have fried products from chicory – Instant chicory (LLC SlavKofe and Instant chicory with hawthorn (Iceberg Ltd and K. No fried products from chicory (Chicory flour (Leroux have lower antioxidant activity then fried products from chicory. Because during frying new compounds are formed – chikoreol, which comprises acetic and valeric acid, acrolein and furfural, furfuryl alcohol, diacetyl. Best convergence results provide spectrophotometric methods using epinephrine and 2,2 – diphenyl-1-picrylhydrazyl.

  10. Assessment of the Tourism Function in Region Development

    Directory of Open Access Journals (Sweden)

    Nataliia Zigern-Korn

    2014-07-01

    Full Text Available This article represents methodical approaches to estimation of tourism value and function in Russian regions development and contains some results of the carried-out assessment. The reasons about tourism mission for different types of territory exploitation and level of social and economic development, the idea of methods of tourist development of regions space are the core lines of the assessment framework. Selection of model regions due to their development types formed information basis for assessment. We determined specific Indicators and algorithm of an assessment to each model region. Results of the carried-out assessment allow rethinking the category of tourist and recreational potential of the territory from the standpoint of prospects and principles of a sustainable development. The technique of such impact assessment of tourism on regional development opens opportunity for public authorities to adopt correct strategic decisions according to the principles of Smart Development.

  11. Irradiation of sewage sludge using cesium-137: a comparative assessment

    International Nuclear Information System (INIS)

    1980-06-01

    Irradiation using 137 CS is a recently developed process for disinfecting sewage sludge before applying it to the land. Irradiation, composting, and heat drying are Processes to Further Reduce Pathogens (PFRP) when operated to meet the guidelines set forth under Title 40, Code of the Federal Register, Part 257 (40 CFR 257). This report identifies and develops technical, operational, and environmental considerations for sludge handling systems incorporating these PFRP to determine the economic advantages of each process. The results indicate that sludge irradiation systems are cost-competitive with composting and heat drying systems for wastewater treatment plants with or without existing anaerobic digesters. Irradiation can thus be considered for new as well as upgrading existing facilities for sludge disinfection. An attractive aspect of the irradiation process is that significantly less conventional energy is used for operation when compared to composting and heat drying. In the final analysis, however, the applicability and desirability of any process is best determined by more evaluations specific to a given community

  12. Climate change mitigation: comparative assessment of Malaysian and ASEAN scenarios.

    Science.gov (United States)

    Rasiah, Rajah; Ahmed, Adeel; Al-Amin, Abul Quasem; Chenayah, Santha

    2017-01-01

    This paper analyses empirically the optimal climate change mitigation policy of Malaysia with the business as usual scenario of ASEAN to compare their environmental and economic consequences over the period 2010-2110. A downscaling empirical dynamic model is constructed using a dual multidisciplinary framework combining economic, earth science, and ecological variables to analyse the long-run consequences. The model takes account of climatic variables, including carbon cycle, carbon emission, climatic damage, carbon control, carbon concentration, and temperature. The results indicate that without optimal climate policy and action, the cumulative cost of climate damage for Malaysia and ASEAN as a whole over the period 2010-2110 would be MYR40.1 trillion and MYR151.0 trillion, respectively. Under the optimal policy, the cumulative cost of climatic damage for Malaysia would fall to MYR5.3 trillion over the 100 years. Also, the additional economic output of Malaysia will rise from MYR2.1 billion in 2010 to MYR3.6 billion in 2050 and MYR5.5 billion in 2110 under the optimal climate change mitigation scenario. The additional economic output for ASEAN would fall from MYR8.1 billion in 2010 to MYR3.2 billion in 2050 before rising again slightly to MYR4.7 billion in 2110 in the business as usual ASEAN scenario.

  13. COMPARATIVE STUDY ON MAIN SOLVENCY ASSESSMENT MODELS FOR INSURANCE FIELD

    Directory of Open Access Journals (Sweden)

    Daniela Nicoleta SAHLIAN

    2015-07-01

    Full Text Available During the recent financial crisis of insurance domain, there were imposed new aspects that have to be taken into account concerning the risks management and surveillance activity. The insurance societies could develop internal models in order to determine the minimum capital requirement imposed by the new regulations that are to be adopted on 1 January 2016. In this respect, the purpose of this research paper is to offer a real presentation and comparing with the main solvency regulation systems used worldwide, the accent being on their common characteristics and current tendencies. Thereby, we would like to offer a better understanding of the similarities and differences between the existent solvency regimes in order to develop the best regime of solvency for Romania within the Solvency II project. The study will show that there are clear differences between the existent Solvency I regime and the new approaches based on risk and will also point out the fact that even the key principles supporting the new solvency regimes are convergent, there are a lot of approaches for the application of these principles. In this context, the question we would try to find the answer is "how could the global solvency models be useful for the financial surveillance authority of Romania for the implementation of general model and for the development of internal solvency models according to the requirements of Solvency II" and "which would be the requirements for the implementation of this type of approach?". This thing makes the analysis of solvency models an interesting exercise.

  14. A comparative toxicity assessment of materials used in aquatic construction.

    Science.gov (United States)

    Lalonde, Benoit A; Ernst, William; Julien, Gary; Jackman, Paula; Doe, Ken; Schaefer, Rebecca

    2011-10-01

    Comparative toxicity testing was performed on selected materials that may be used in aquatic construction projects. The tests were conducted on the following materials: (1) untreated wood species (hemlock [Tsuga ssp], Western red cedar (Thuja plicata), red oak [Quercus rubra], Douglas fir [Pseudotsuga menziesii], red pine [Pinus resinosa], and tamarack [Larix ssp]); (2) plastic wood; (3) Ecothermo wood hemlock stakes treated with preservatives (e.g., chromated copper arsenate [CCA], creosote, alkaline copper quaternary [ACQ], zinc naphthenate, copper naphthenate, and Lifetime Wood Treatment); (4) epoxy-coated steel; (5) hot-rolled steel; (6) zinc-coated steel; and (7) concrete. Those materials were used in acute lethality tests with rainbow trout, Daphnia magna, Vibrio fischeri and threespine stickleback. The results indicated the following general ranking of the materials (from the lowest to highest LC(50) values); ACQ > creosote > zinc naphthenate > copper naphthenate > CCA (treated at 22.4 kg/m(3)) > concrete > red pine > western red cedar > red oak > zinc-coated steel > epoxy-coated steel > CCA (6.4 kg/m(3)). Furthermore, the toxicity results indicated that plastic wood, certain untreated wood species (hemlock, tamarack, Douglas fir, and red oak), hot-rolled steel, Ecothermo wood, and wood treated with Lifetime Wood Treatment were generally nontoxic to the test species. © Springer Science+Business Media, LLC 2011

  15. A brief assessment of physical functioning for prostate cancer patients

    Directory of Open Access Journals (Sweden)

    Jin-Shei Lai

    2010-06-01

    Full Text Available Jin-Shei Lai1, Rita Bode2, Hwee-Lin Wee3, David Eton4, David Cella11Department of Medical Social Sciences, 2Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, IL USA; 3Department of Pharmacy, National University of Singapore, Singapore; 4Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USAAbstract: We aimed to validate a more rapid, yet reliable means of assessing physical function (PF for patients with prostate cancer. The sample included 128 prostate cancer patients recruited from urology and general oncology clinics at two Chicago-area hospitals. The main outcome measures were: A 36-item PF item bank that included a 5-item short form (BriefPF and the 10-item PF subscale (PF-10 from the Medical Outcomes Study SF-36. Validity, information function, and relative precision (calculated using Rasch analysis and raw scores of the BriefPF were compared to the PF-10 and the full PF item bank. We found that the BriefPF and PF-10 were strongly correlated (r = 0.85 with the PF bank, and all three scales differentiated patients according to performance status (FPF bank(2,124 = 32.51 P < 0.001, FPF-10(2,121 = 27.35 P < 0.001, FBriefPF (2,123 = 38.40 P < 0.001. BriefPF has excellent precision relative to the PF-10 in measuring patients with different performance status levels. The Rasch-based information function indicated that the BriefPF was more informative than PF-10 in measuring moderate to higher functioning patients. Hence, the BriefPF offers a parsimonious and precise measure of PF for use among men with prostate cancer, and may aid in the timely inclusion of patient-reported outcomes in treatment decision-making.Keywords: quality-of-life, item bank, short-form, Medical Outcomes Study

  16. Análise comparativa da função respiratória de indivíduos hígidos em solo e na água Comparative assessment of healthy subjects' lung function on the ground and in water

    Directory of Open Access Journals (Sweden)

    Natalia Cristina de Sá

    2010-12-01

    Full Text Available A mensuração da função respiratória oferece informações essenciais para caracterizar anormalidades pulmonares. A pressão hidrostática da água atua no tórax submerso de diversas formas, causando alterações no sistema respiratório. O objetivo deste estudo foi analisar comparativamente variáveis que avaliam a função respiratória - volume minuto (Vmin, volume corrente (Vc, capacidade vital (Cvital e frequência respiratória (FR - de voluntárias no solo e com o tórax submerso em piscina terapêutica aquecida. A função respiratória de 30 voluntárias saudáveis (20,9±2,1 anos; 1,64±0,07 m; 58,8±9,2 kg; índice de massa corporal 21,78±2,63 kg/m² foi avaliada por meio de ventilômetro em solo e aos 1 e 20 minutos de imersão, com água ao nível dos ombros, em posição sentada. Após 20 minutos de imersão, foi registrado aumento estatisticamente significativo no Vmin (p=0,015 e Vc (p=0,027; e uma redução estatisticamente significativa (p=0,016 na Cvital 1 minuto após imersão, em relação aos valores obtidos em solo. O maior tempo de imersão alterou assim os valores obtidos em solo, com exceção da Cvital, que sofreu alteração significativa desde o primeiro minuto de imersão. Não foram encontradas diferenças significativas entre os valores obtidos após 1 e 20 minutos na água. O estudo permite concluir que a imersão do tórax em piscina aquecida provocou aumento no Vmin e Vc e diminuição na Cvital de voluntárias saudáveis.Measuring respiratory function provides essential information to assess pulmonary changes. Effects of water hydrostatic pressure on the submerged chest cause changes in the respiratory system. The purpose here was to compare respiratory function variables - minute volume (MV, tidal volume (TV, vital capacity (Vitalc, and respiratory rate (RR - on the ground and with chest submerged in water. Respiratory function of 30 healthy female volunteers (mean age 20.93 ± 2.11; weight 58.8±9.2 kg

  17. Assessing the Ability of Disability Organizations: An interprovincial comparative perspective

    Directory of Open Access Journals (Sweden)

    Mario Levesque

    2012-12-01

    Full Text Available Despite much effort put toward Canadian social policy renewal in the past decade, innovations in programming have been stifled due in large part to a lack of funding and accountability issues. This is clearly evident in the disability policy field related to labour market programming for persons with disabilities where the packaging of programs has continually changed; however, the actual contents have largely remained the same. The focus on federal-provincial dimensions has come to marginalize the role of disability organizations in the process, yet it is these organizations that governments may enter into partnership with in new governance arrangements to foster new programming. This article reviews data from charitable tax returns for the time period 2005–2010 to assess the human, financial, and technological capacity of Canadian disability organizations in five Canadian provinces, in order to implement innovative programming.RÉSUMÉMalgré beaucoup d'efforts au renouvellement de la politique sociale canadienne dans la dernière décennie, les innovations dans la programmation ont été étouffées en grande partie à l'absence de questions de financement et de responsabilité. Cela est très évidente dans le domaine de la politique handicap lié à la programmation du marché du travail pour les personnes handicapées où l'emballage des programmes a constamment changé mais le contenu réel est restés largement pareilles. L'accent sur les dimensions provinciales fédérales est venu à marginaliser le rôle des organisations de personnes handicapées dans le processus, mais ce sont ces organismes que les gouvernements peuvent entrer en partenariat avec de nouveaux modes de gouvernance pour favoriser la nouvelle programmation. Cet article examine les données de bienfaisance des déclarations de revenus pour la période 2005–2010 pour évaluer les capacités humaines, financières et technologiques des organisations de personnes

  18. Functional, Structural, and Neurotoxicity Biomarkers in Integrative Assessment of Concussions

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    Svetlana A Dambinova

    2016-10-01

    Full Text Available Concussion is a complex, heterogenous process affecting the brain. Accurate assessment and diagnosis and appropriate management of concussion are essential to ensure athletes do not prematurely return to play or others to work or active military duty, risking re-injury. To date, clinical diagnosis relies primarily on evaluating subjects for functional impairment using instruments that include neurocognitive testing, subjective symptom report, and neurobehavioral assessments, such as balance and vestibular-ocular reflex testing. Structural biomarkers, defined as advanced neuroimaging techniques and biomarkers assessing neurotoxicity and immunoexcitotoxicity may complement the use of functional biomarkers. We hypothesize that neurotoxicity AMPA, NMDA, and kainite receptor biomarkers might be utilized as a part of comprehensive approach to concussion evaluations, with the goal of increasing diagnostic accuracy and facilitating treatment planning and prognostic assessment.

  19. Comparative assessment of electricity generation options for Mexico

    International Nuclear Information System (INIS)

    Cecilia, Martin Del Campo; Francois, Juan Luis

    2009-01-01

    This paper presents an approach to the evaluation of sustainability of energy options for the electricity generation in Mexico. The study evaluated technologies that could be planned in the short term because their high maturity. The purpose was to rank the energy options based on the evaluation of a set of criteria grouped in impact areas for each dimension of the sustainability: economic, environmental and social. Obviously, no single technology exhibited superior performance on the basis of all the criteria and it was necessary to apply a mult criteria decision analysis (MCDA). In total this study all the decision elements were combined and integrated in an inference fuzzy logic system that takes into account the weights of different indicators. The methodology was applied to compare five technologies based on wind, nuclear, natural gas, coal, hydro and oil resources under the current Mexican conditions. In view of the features of the energy options, oil and gas are subject to limited energy resources. Coal and oil show relatively unfavorable ecological and accident risk characteristics. Gas is by far the option with the best performance among the fossil fuel options. In the case of nuclear energy, the economic, environmental and health indicators are highly favorable, however, social indicators for nuclear energy are unfavorable but they are also very controversial and additional studies must be carried out. The global sustainability of hydro, nuclear, wind and natural gas resulted very close; so these energy options must be considered in the generation expansion planning studies to search the expansion plans with the better combination of generation, energetic diversification and emissions, between other criteria

  20. Ultrasonographic Assessment of Diaphragm Function in Critically Ill Subjects.

    Science.gov (United States)

    Umbrello, Michele; Formenti, Paolo

    2016-04-01

    The majority of patients admitted to the ICU require mechanical ventilation as a part of their process of care. However, mechanical ventilation itself or the underlying disease can lead to dysfunction of the diaphragm, a condition that may contribute to the failure of weaning from mechanical ventilation. However, extended time on the ventilator increases health-care costs and greatly increases patient morbidity and mortality. Nevertheless, symptoms and signs of muscle disease in a bedridden (or bed rest-only) ICU patient are often difficult to assess because of concomitant confounding factors. Conventional assessment of diaphragm function lacks specific, noninvasive, time-saving, and easily performed bedside tools or requires patient cooperation. Recently, the use of ultrasound has raised great interest as a simple, noninvasive method of quantification of diaphragm contractile activity. In this review, we discuss the physiology and the relevant pathophysiology of diaphragm function, and we summarize the recent findings concerning the evaluation of its (dys)function in critically ill patients, with a special focus on the role of ultrasounds. We describe how to assess diaphragm excursion and diaphragm thickening during breathing and the meaning of these measurements under spontaneous or mechanical ventilation as well as the reference values in health and disease. The spread of ultrasonographic assessment of diaphragm function may possibly result in timely identification of patients with diaphragm dysfunction and to a potential improvement in the assessment of recovery from diaphragm weakness. Copyright © 2016 by Daedalus Enterprises.

  1. Video Quality Assessment Using Spatio-Velocity Contrast Sensitivity Function

    Science.gov (United States)

    Hirai, Keita; Tumurtogoo, Jambal; Kikuchi, Ayano; Tsumura, Norimichi; Nakaguchi, Toshiya; Miyake, Yoichi

    Due to the development and popularization of high-definition televisions, digital video cameras, Blu-ray discs, digital broadcasting, IP television and so on, it plays an important role to identify and quantify video quality degradations. In this paper, we propose SV-CIELAB which is an objective video quality assessment (VQA) method using a spatio-velocity contrast sensitivity function (SV-CSF). In SV-CIELAB, motion information in videos is effectively utilized for filtering unnecessary information in the spatial frequency domain. As the filter to apply videos, we used the SV-CSF. It is a modulation transfer function of the human visual system, and consists of the relationship among contrast sensitivities, spatial frequencies and velocities of perceived stimuli. In the filtering process, the SV-CSF cannot be directly applied in the spatial frequency domain because spatial coordinate information is required when using velocity information. For filtering by the SV-CSF, we obtain video frames separated in spatial frequency domain. By using velocity information, the separated frames with limited spatial frequencies are weighted by contrast sensitivities in the SV-CSF model. In SV-CIELAB, the criteria are obtained by calculating image differences between filtered original and distorted videos. For the validation of SV-CIELAB, subjective evaluation experiments were conducted. The subjective experimental results were compared with SV-CIELAB and the conventional VQA methods such as CIELAB color difference, Spatial-CIELAB, signal to noise ratio and so on. From the experimental results, it was shown that SV-CIELAB is a more efficient VQA method than the conventional methods.

  2. Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis

    Directory of Open Access Journals (Sweden)

    van Eijk RPA

    2018-03-01

    Full Text Available Ruben PA van Eijk,1 Marinus JC Eijkemans,2 Dimitris Rizopoulos,3 Leonard H van den Berg,4,* Stavros Nikolakopoulos5,* 1Department of Neurology, University Medical Center Utrecht, Utrecht, the Netherlands; 2Department of Biostatistics, University Medical Center Utrecht, Utrecht, the Netherlands; 3Department of Biostatistics, Erasmus University Medical Center, Rotterdam, the Netherlands; 4Department of Neurology, University Medical Center Utrecht, Utrecht, the Netherlands; 5Department of Biostatistics, University Medical Center Utrecht, Utrecht, the Netherlands *These authors contributed equally to this work Objective: Amyotrophic lateral sclerosis (ALS clinical trials based on single end points only partially capture the full treatment effect when both function and mortality are affected, and may falsely dismiss efficacious drugs as futile. We aimed to investigate the statistical properties of several strategies for the simultaneous analysis of function and mortality in ALS clinical trials. Methods: Based on the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT database, we simulated longitudinal patterns of functional decline, defined by the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R and conditional survival time. Different treatment scenarios with varying effect sizes were simulated with follow-up ranging from 12 to 18 months. We considered the following analytical strategies: 1 Cox model; 2 linear mixed effects (LME model; 3 omnibus test based on Cox and LME models; 4 composite time-to-6-point decrease or death; 5 combined assessment of function and survival (CAFS; and 6 test based on joint modeling framework. For each analytical strategy, we calculated the empirical power and sample size. Results: Both Cox and LME models have increased false-negative rates when treatment exclusively affects either function or survival. The joint model has superior power compared to other strategies. The composite end point

  3. Assessment of comparative and non-comparative factors in alternate energy system

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, W D; Oterson, P

    1983-01-01

    The American University Institute for Risk Analysis (AURA) has undertaken a study for the European Economic Community to critically evaluate the methodologies for comparative risk analyses and costs and benefits of alternative energy systems used to generate electricity, principally nuclear, coal, and oil. Other energy systems and related industries with major hazards are also addressed where pertinent. This is particularly true for cases where electrical energy may be an inefficient form for end use as for transportation and space heating. Here, comparison on an end use basis by the most efficient method, electrical or otherwise, is required. The starting point and basis for this evaluation has been the array of existing studies of alternative energy systems already published. These studies, including those already undertaken by the Community, are over 50 in number. The purpose of this study is not to make a comparison of alternative energy systems, but to evaluate what is and what is not useful in existing studies, as well as to provide insight on how meaningful studies can be conducted. There has been considerable criticism and discussion about the conduct and validity of several studies, particularly the Inhaber study and the critiques of Holdren et al. While much of the critiques deal with methods and approaches, substantial criticism and discussion has focused on the motivations of the investigators and how the studies were applied. This latter set of issues is hardly a technological or methodological argument.

  4. How Effective Are Self- and Peer Assessment of Oral Presentation Skills Compared with Teachers' Assessments?

    Science.gov (United States)

    De Grez, Luc; Valcke, Martin; Roozen, Irene

    2012-01-01

    Assessment of oral presentation skills is an underexplored area. The study described here focuses on the agreement between professional assessment and self- and peer assessment of oral presentation skills and explores student perceptions about peer assessment. The study has the merit of paying attention to the inter-rater reliability of the…

  5. Methods for assessing the effects of dehydration on cognitive function.

    Science.gov (United States)

    Lieberman, Harris R

    2012-11-01

    Studying the effects of dehydration on cognitive function presents a variety of unique and difficult challenges to investigators. These challenges, which are addressed in this article, can be divided into three general categories: 1) choosing an appropriate method of generating a consistent level of dehydration; 2) determining and effectively employing appropriate and sensitive measures of cognitive state; and 3) adequately controlling the many confounding factors that interfere with assessment of cognitive function. The design and conduct of studies on the effects of dehydration on cognitive function should carefully consider various methodological issues, and investigators should carefully weigh the benefits and disadvantages of particular methods and procedures. © 2012 International Life Sciences Institute.

  6. Assessing executive functions in preschoolers using Shape School Task

    Directory of Open Access Journals (Sweden)

    Marta Nieto

    2016-09-01

    Full Text Available Over the last two decades, there has been a growing interest in the study of the development of executive functions in preschool children due to their relationship with different cognitive, psychological, social and academic domains. Early detection of individual differences in executive functioning can have major implications for basic and applied research. Consequently, there is a key need for assessment tools adapted to preschool skills: Shape School has been shown to be a suitable task for this purpose. Our study uses Shape School as the main task to analyze development of inhibition, task-switching and working memory in a sample of 304 preschoolers (age range 3.25-6.50 years. Additionally, we include cognitive tasks for the evaluation of verbal variables (vocabulary, word reasoning and short-term memory and performance variables (picture completion and symbol search, so as to analyze their relationship with executive functions. Our results show age-associated improvements in executive functions and the cognitive variables assessed. Furthermore, correlation analyses reveal positive relationships between executive functions and the other cognitive variables. More specifically, using structural equation modeling and including age direct and indirect effects, our results suggest that executive functions explain to a greater extent performance on verbal and performance tasks. These findings provide further information to support research that considers preschool age to be a crucial period for the development of executive functions and their relationship with other cognitive processes

  7. Questionnaire-based assessment of executive functioning: Psychometrics.

    Science.gov (United States)

    Castellanos, Irina; Kronenberger, William G; Pisoni, David B

    2018-01-01

    The psychometric properties of the Learning, Executive, and Attention Functioning (LEAF) scale were investigated in an outpatient clinical pediatric sample. As a part of clinical testing, the LEAF scale, which broadly measures neuropsychological abilities related to executive functioning and learning, was administered to parents of 118 children and adolescents referred for psychological testing at a pediatric psychology clinic; 85 teachers also completed LEAF scales to assess reliability across different raters and settings. Scores on neuropsychological tests of executive functioning and academic achievement were abstracted from charts. Psychometric analyses of the LEAF scale demonstrated satisfactory internal consistency, parent-teacher inter-rater reliability in the small to large effect size range, and test-retest reliability in the large effect size range, similar to values for other executive functioning checklists. Correlations between corresponding subscales on the LEAF and other behavior checklists were large, while most correlations with neuropsychological tests of executive functioning and achievement were significant but in the small to medium range. Results support the utility of the LEAF as a reliable and valid questionnaire-based assessment of delays and disturbances in executive functioning and learning. Applications and advantages of the LEAF and other questionnaire measures of executive functioning in clinical neuropsychology settings are discussed.

  8. Spatial Assessment of Forest Ecosystem Functions and Services using Human Relating Factors for SDG

    Science.gov (United States)

    Song, C.; Lee, W. K.; Jeon, S. W.; Kim, T.; Lim, C. H.

    2015-12-01

    Application of ecosystem service concept in environmental related decision making could be numerical and objective standard for policy maker between preserving and developing perspective of environment. However, pursuing maximum benefit from natural capital through ecosystem services caused failure by losing ecosystem functions through its trade-offs. Therefore, difference between ecosystem functions and services were demonstrated and would apply human relating perspectives. Assessment results of ecosystem functions and services can be divided 3 parts. Tree growth per year set as the ecosystem function factor and indicated through so called pure function map. After that, relating functions can be driven such as water conservation, air pollutant purification, climate change regulation, and timber production. Overall process and amount are numerically quantified. These functional results can be transferred to ecosystem services by multiplying economic unit value, so function reflecting service maps can be generated. On the other hand, above services, to implement more reliable human demand, human reflecting service maps are also be developed. As the validation, quantified ecosystem functions are compared with former results through pixel based analysis. Three maps are compared, and through comparing difference between ecosystem function and services and inversed trends in function based and human based service are analysed. In this study, we could find differences in PF, FRS, and HRS in relation to based ecosystem conditions. This study suggests that the differences in PF, FRS, and HRS should be understood in the decision making process for sustainable management of ecosystem services. Although the analysis is based on in sort existing process separation, it is important to consider the possibility of different usage of ecosystem function assessment results and ecosystem service assessment results in SDG policy making. Furthermore, process based functional approach

  9. Life cycle assessments of urban water systems: a comparative analysis of selected peer-reviewed literature.

    Science.gov (United States)

    Loubet, Philippe; Roux, Philippe; Loiseau, Eleonore; Bellon-Maurel, Veronique

    2014-12-15

    Water is a growing concern in cities, and its sustainable management is very complex. Life cycle assessment (LCA) has been increasingly used to assess the environmental impacts of water technologies during the last 20 years. This review aims at compiling all LCA papers related to water technologies, out of which 18 LCA studies deals with whole urban water systems (UWS). A focus is carried out on these 18 case studies which are analyzed according to criteria derived from the four phases of LCA international standards. The results show that whereas the case studies share a common goal, i.e., providing quantitative information to policy makers on the environmental impacts of urban water systems and their forecasting scenarios, they are based on different scopes, resulting in the selection of different functional units and system boundaries. A quantitative comparison of life cycle inventory and life cycle impact assessment data is provided, and the results are discussed. It shows the superiority of information offered by multi-criteria approaches for decision making compared to that derived from mono-criterion. From this review, recommendations on the way to conduct the environmental assessment of urban water systems are given, e.g., the need to provide consistent mass balances in terms of emissions and water flows. Remaining challenges for urban water system LCAs are identified, such as a better consideration of water users and resources and the inclusion of recent LCA developments (territorial approaches and water-related impacts). Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Efficacy of language assessment in Alzheimer's disease: comparing in-person examination and telemedicine.

    Science.gov (United States)

    Vestal, Lindsey; Smith-Olinde, Laura; Hicks, Gretchen; Hutton, Terri; Hart, John

    2006-01-01

    With the large number of aging individuals requiring screening of cognitive functions for dementing illnesses, there is a necessity for innovative evaluation approaches. One domain that should allow for online, at a distance, examination is speech and language dysfunction, if the auditory and visual transmission is of sufficient quality to allow adequate patient participation and reliable, valid interpretation of signs and symptoms (Duffy et al 1997). Examine the effectiveness of language assessment in mild Alzheimer's patients using telemedicine (TM) compared with traditional in-person (IP) assessment. Ten patients with mild Alzheimer's disease, enrolled at a Geriatric Memory Clinic received a battery of standard language tests under two conditions: face-to-face and via satellite TM. Comparison of TM and IP testing conditions were assessed within each for scores on each test in the two conditions. On each of the five language tasks, the Wilcoxon signed ranks test indicated no significant difference on performance between the TM and IP conditions for each participant. Overall acceptance of the TM evaluation in an elderly population was rated at a high level except for one individual. Telemedicine can improve access to speech and language evaluation services which is relevant to both dementia and other neurological diseases of the elderly. In particular, this specific assessment tool can be used to provide evaluations in under-served rural areas.

  11. Functional Assessment-Based Intervention for Selective Mutism

    Science.gov (United States)

    Kern, Lee; Starosta, Kristin M.; Bambara, Linda M.; Cook, Clayton R.; Gresham, Frank R.

    2007-01-01

    The process of functional assessment has emerged as an essential component for intervention development. Applications across divergent types of problem behavior, however, remain limited. This study evaluated the applicability of this promising approach to students with selective mutism. Two middle school students served as participants. The…

  12. Fun cube based brain gym cognitive function assessment system.

    Science.gov (United States)

    Zhang, Tao; Lin, Chung-Chih; Yu, Tsang-Chu; Sun, Jing; Hsu, Wen-Chuin; Wong, Alice May-Kuen

    2017-05-01

    The aim of this study is to design and develop a fun cube (FC) based brain gym (BG) cognitive function assessment system using the wireless sensor network and multimedia technologies. The system comprised (1) interaction devices, FCs and a workstation used as interactive tools for collecting and transferring data to the server, (2) a BG information management system responsible for managing the cognitive games and storing test results, and (3) a feedback system used for conducting the analysis of cognitive functions to assist caregivers in screening high risk groups with mild cognitive impairment. Three kinds of experiments were performed to evaluate the developed FC-based BG cognitive function assessment system. The experimental results showed that the Pearson correlation coefficient between the system's evaluation outcomes and the traditional Montreal Cognitive Assessment scores was 0.83. The average Technology Acceptance Model 2 score was close to six for 31 elderly subjects. Most subjects considered that the brain games are interesting and the FC human-machine interface is easy to learn and operate. The control group and the cognitive impairment group had statistically significant difference with respect to the accuracy of and the time taken for the brain cognitive function assessment games, including Animal Naming, Color Search, Trail Making Test, Change Blindness, and Forward / Backward Digit Span. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Functional assessment of patients after total knee replacement

    Directory of Open Access Journals (Sweden)

    Matla Joanna

    2017-06-01

    Full Text Available Introduction: In the society of the 21st century, osteoarthritis is considered one of the primary causes of the occurrence of pain and disability. Arthroplasty is the treatment of choice for advanced degenerative changes. The aim of the study was to carry out a functional assessment of patients at early stages of rehabilitation after total knee replacement.

  14. MIMIC Methods for Assessing Differential Item Functioning in Polytomous Items

    Science.gov (United States)

    Wang, Wen-Chung; Shih, Ching-Lin

    2010-01-01

    Three multiple indicators-multiple causes (MIMIC) methods, namely, the standard MIMIC method (M-ST), the MIMIC method with scale purification (M-SP), and the MIMIC method with a pure anchor (M-PA), were developed to assess differential item functioning (DIF) in polytomous items. In a series of simulations, it appeared that all three methods…

  15. Assessment of lung function in a large cohort of patients with acromegaly.

    Science.gov (United States)

    Störmann, Sylvère; Gutt, Bodo; Roemmler-Zehrer, Josefine; Bidlingmaier, Martin; Huber, Rudolf M; Schopohl, Jochen; Angstwurm, Matthias W

    2017-07-01

    Acromegaly is associated with increased mortality due to respiratory disease. To date, lung function in patients with acromegaly has only been assessed in small studies, with contradicting results. We assessed lung function parameters in a large cohort of patients with acromegaly. Lung function of acromegaly patients was prospectively assessed using spirometry, blood gas analysis and body plethysmography. Biochemical indicators of acromegaly were assessed through measurement of growth hormone and IGF-I levels. This study was performed at the endocrinology outpatient clinic of a tertiary referral center in Germany. We prospectively tested lung function of 109 acromegaly patients (53 male, 56 female; aged 24-82 years; 80 with active acromegaly) without severe acute or chronic pulmonary disease. We compared lung volume, air flow, airway resistance and blood gases to normative data. Acromegaly patients had greater lung volumes (maximal vital capacity, intra-thoracic gas volume and residual volume: P  acromegaly. Female patients had significantly altered lung function in terms of subclinical airway obstruction. In our cross-sectional analysis of lung function in 109 patients with acromegaly, lung volumes were increased compared to healthy controls. Additionally, female patients showed signs of subclinical airway obstruction. There was no difference between patients with active acromegaly compared with patients biochemically in remission. © 2017 European Society of Endocrinology.

  16. Incubation period and immune function: A comparative field study among coexisting birds

    Science.gov (United States)

    Palacios, M.G.; Martin, T.E.

    2006-01-01

    Developmental periods are integral components of life history strategies that can have important fitness consequences and vary enormously among organisms. However, the selection pressures and mechanisms causing variation in length of developmental periods are poorly understood. Particularly puzzling are prolonged developmental periods, because their selective advantage is unclear. Here we tested the hypotheses that immune function is stronger in species that are attacked at a higher rate by parasites and that prolonged embryonic development allows the development of this stronger immune system. Through a comparative field study among 12 coexisting passerine bird species, we show that species with higher blood parasite prevalence mounted stronger cellular immune responses than species with lower prevalence. These results provide support for the hypothesis that species facing greater selection pressure from parasites invest more in immune function. However, species with longer incubation periods mounted weaker cellular immune responses than species with shorter periods. Therefore, cellular immune responses do not support the hypothesis that longer development time enhances immunocompentence. Future studies should assess other components of the immune system and test alternative causes of variation in incubation periods among bird species. ?? Springer-Verlag 2005.

  17. Beyond the global assessment of functioning: learning from Virginia Apgar.

    Science.gov (United States)

    Dimsdale, Joel E; Jeste, Dilip V; Patterson, Thomas L

    2010-01-01

    The Global Assessment of Functioning (GAF) scale is widely used in psychiatry, yet it has certain drawbacks. The authors seek to generate further discussion and research around developing an improved successor to the GAF. The authors used the Apgar scale as a template for constructing a possible successor to the GAF. Consulting with 16 colleagues, they selected 5 domains that were felt to be central to functioning in psychiatric patients. Psychiatrists in diverse clinical settings then completed both a GAF and a Psychiatric Apgar scale on 40 patients. The two scales were found to agree significantly. Use of the Psychiatric Apgar, however, provides clearer guidance about assessing functioning. The GAF was a brilliant addition to psychiatric practice. As we develop the next Diagnostic and Statistical Manual, it is pertinent to ask whether the GAF approach could be optimized even further by applying the lessons of Virginia Apgar.

  18. Decreased functional diversity and biological pest control in conventional compared to organic crop fields.

    Directory of Open Access Journals (Sweden)

    Jochen Krauss

    Full Text Available Organic farming is one of the most successful agri-environmental schemes, as humans benefit from high quality food, farmers from higher prices for their products and it often successfully protects biodiversity. However there is little knowledge if organic farming also increases ecosystem services like pest control. We assessed 30 triticale fields (15 organic vs. 15 conventional and recorded vascular plants, pollinators, aphids and their predators. Further, five conventional fields which were treated with insecticides were compared with 10 non-treated conventional fields. Organic fields had five times higher plant species richness and about twenty times higher pollinator species richness compared to conventional fields. Abundance of pollinators was even more than one-hundred times higher on organic fields. In contrast, the abundance of cereal aphids was five times lower in organic fields, while predator abundances were three times higher and predator-prey ratios twenty times higher in organic fields, indicating a significantly higher potential for biological pest control in organic fields. Insecticide treatment in conventional fields had only a short-term effect on aphid densities while later in the season aphid abundances were even higher and predator abundances lower in treated compared to untreated conventional fields. Our data indicate that insecticide treatment kept aphid predators at low abundances throughout the season, thereby significantly reducing top-down control of aphid populations. Plant and pollinator species richness as well as predator abundances and predator-prey ratios were higher at field edges compared to field centres, highlighting the importance of field edges for ecosystem services. In conclusion organic farming increases biodiversity, including important functional groups like plants, pollinators and predators which enhance natural pest control. Preventative insecticide application in conventional fields has only short

  19. Decreased functional diversity and biological pest control in conventional compared to organic crop fields.

    Science.gov (United States)

    Krauss, Jochen; Gallenberger, Iris; Steffan-Dewenter, Ingolf

    2011-01-01

    Organic farming is one of the most successful agri-environmental schemes, as humans benefit from high quality food, farmers from higher prices for their products and it often successfully protects biodiversity. However there is little knowledge if organic farming also increases ecosystem services like pest control. We assessed 30 triticale fields (15 organic vs. 15 conventional) and recorded vascular plants, pollinators, aphids and their predators. Further, five conventional fields which were treated with insecticides were compared with 10 non-treated conventional fields. Organic fields had five times higher plant species richness and about twenty times higher pollinator species richness compared to conventional fields. Abundance of pollinators was even more than one-hundred times higher on organic fields. In contrast, the abundance of cereal aphids was five times lower in organic fields, while predator abundances were three times higher and predator-prey ratios twenty times higher in organic fields, indicating a significantly higher potential for biological pest control in organic fields. Insecticide treatment in conventional fields had only a short-term effect on aphid densities while later in the season aphid abundances were even higher and predator abundances lower in treated compared to untreated conventional fields. Our data indicate that insecticide treatment kept aphid predators at low abundances throughout the season, thereby significantly reducing top-down control of aphid populations. Plant and pollinator species richness as well as predator abundances and predator-prey ratios were higher at field edges compared to field centres, highlighting the importance of field edges for ecosystem services. In conclusion organic farming increases biodiversity, including important functional groups like plants, pollinators and predators which enhance natural pest control. Preventative insecticide application in conventional fields has only short-term effects on aphid

  20. A comparative assessment of the health status of feral populations of ...

    African Journals Online (AJOL)

    A comparative assessment of the health status of feral populations of Clarias gariepinus from three dams in the Limpopo and Olifants river systems, Limpopo province, South Africa, using the fish health assessment index protocol.

  1. Cardiopulmonary determinants of functional capacity in patients with chronic heart failure compared with normals.

    Science.gov (United States)

    Meyer, K; Westbrook, S; Schwaibold, M; Hajric, R; Lehmann, M; Roskamm, H

    1996-12-01

    Patients with chronic heart failure (CHF) are characterized by abnormal gas exchange and ventilatory responses to exercise. This study compares variables obtained from cardiopulmonary exercise testing in 35 patients with CHF with 35 age- and weight-matched healthy subjects. A second goal was to obtain cardiopulmonary variables measured at ventilatory threshold to distinguish patient changes from those of healthy subjects. Exercise testing was carried out using bicycle ergometry with ramplike protocol (work rate increments 12.5 W/min). Gas exchange and ventilation were measured breath by breath. Compared with healthy subjects, the VO2 in patients was lower at identical work rates (p rate, the variables for VO2, VCO2, ventilation, O2 pulse, ventilatory equivalents for O2 and CO2, and VD/VT (physiologic deadspace to tidal volume ratio), as well as lactate differed significantly at identical work rates. With the exception of VD/VT, all cardiopulmonary variables showed significant differences in their slopes during exercise. By means of a discriminant analysis, VCO2 and ventilation proved to be the most distinguishing variables at ventilatory threshold between patients with CHF and healthy subjects. These results indicate the clinical usefulness of cardiopulmonary exercise testing when assessing functional impairment due to CHF. For treatment evaluation, not only VO2 but also VCO2 and ventilation responses to exercise should be considered.

  2. ASSESSMENT CRITERIA OF FUNCTIONALITY GEOTEXTILES USED IN ROAD CONSTRUCTION

    Directory of Open Access Journals (Sweden)

    LUCA Cristinel

    2016-05-01

    Full Text Available This work was performed in order to assess the functionality of geotextiles used in road construction. To increase the quality of road works requires the use of geotextiles in their structure. Depending on the role and the benefits they offer, geotextiles have a number of physical properties, hydraulic, endurance and optimal characteristics regarding their degradation. Geotextile properties were identified and divided according to their characteristics area. Thus, there were obtained textile properties oriented towards geotextiles and properties geared to the application field respectively reinforcement, drainage, and filtration. Value engineering works at the level of constructive product conception and production. The instrumentation is done by functional analysis, value functions and design or redesign of geotextile based on the necessary functions. Systematic research method allowed geotextiles dimensioning functions in order to obtain products in terms of quality, reliability and maximum operational performance. Functions obtained from the analysis are appropriate for a single property. After obtaining the set of decisions was possible functions geotextiles hierarchy after the significance of their use. Establishing the importance of the coefficients or characteristics hierarchy after their weight requires the comparison of the features between them and grading them in proportion to their degree of importance. The ranking of these functions is beneficial when designing or redesigning geotextiles.

  3. FUNCTIONAL OUTCOME OF INTERTROCHANTERIC FRACTURES AFTER FIXATION WITH PFN OR DHS IN ELDERLY- A COMPARATIVE STUDY

    Directory of Open Access Journals (Sweden)

    Sreekumar K

    2017-05-01

    Full Text Available BACKGROUND Ninety percent of the hip fractures in the elderly result from a simple fall. More than fifty percent of the hip fractures in the elderly are intertrochanteric fractures. The goal of treatment of any intertrochanteric fracture in elderly is to restore mobility at the earliest and minimise the complications of prolonged bed rest. The Dynamic Hip Screw (DHS has been shown to produce good results, but complications are frequent, particularly in unstable intertrochanteric fractures. Intramedullary fixation is considered to provide a more biomechanically stable construct by reducing the distance between the hip joint and implant. MATERIALS AND METHODS The goal of this study is to compare the functional outcome of intertrochanteric fractures in elderly patients treated with Proximal Femoral Nail (PFN and Dynamic Hip Screw (DHS by analysing the clinical and radiological results to evaluate the advantages and disadvantages and possible complications associated with fixation of intertrochanteric fractures with PFN and DHS. 1 In our study, we included 106 intertrochanteric fractures, out of which 46 were treated with PFN and 60 with DHS. Ordinary fracture table was used in all cases and were followed up at regular intervals of 4, 8 and 12 weeks, 6 months and one year. RESULTS Functional results were assessed with modified Harris hip score. We observed significantly higher excellent results and less poor results in PFN compared to DHS. CONCLUSION Unstable intertrochanteric fractures treated with PFN have significantly better outcome than DHS. In unstable fractures, reduction loss, union in varus and limb shortening are significantly higher in DHS. Hence, the advantages of PFN are less surgical trauma, less blood loss and the possibility of early weightbearing even after very complex fractures.

  4. Magnetic resonance in the assessment of renal function

    Energy Technology Data Exchange (ETDEWEB)

    Knesplova, L.; Krestin, G.P. [Department of Radiology, University Hospital Zurich (Switzerland)

    1998-03-01

    The kidneys are the most important organs to maintain homeostasis. In the assessment of renal functional disorders laboratory tests offer only indirect hints on location of the disease; radionuclide nephrography is hampered by low spatial resolution and radiologic methods provide only limited quantitative information. The MRI technique with fast pulse sequences and renally eliminated contrast agent has the capability of combining both anatomic and functional information. This article gives an overview on functional MRI of the kidneys with its possibilities and limitations. The clinical application of functional MRI allows a better understanding of some pathologic conditions such as urinary tract obstruction, renal insufficiency, effects of extracorporeal shock wave lithotripsy, different states of hydration, effects of drugs, vascular disorders, and effects of transplantation. (orig.) With 9 figs., 62 refs.

  5. Magnetic resonance in the assessment of renal function

    International Nuclear Information System (INIS)

    Knesplova, L.; Krestin, G.P.

    1998-01-01

    The kidneys are the most important organs to maintain homeostasis. In the assessment of renal functional disorders laboratory tests offer only indirect hints on location of the disease; radionuclide nephrography is hampered by low spatial resolution and radiologic methods provide only limited quantitative information. The MRI technique with fast pulse sequences and renally eliminated contrast agent has the capability of combining both anatomic and functional information. This article gives an overview on functional MRI of the kidneys with its possibilities and limitations. The clinical application of functional MRI allows a better understanding of some pathologic conditions such as urinary tract obstruction, renal insufficiency, effects of extracorporeal shock wave lithotripsy, different states of hydration, effects of drugs, vascular disorders, and effects of transplantation. (orig.)

  6. Use of the catena principle in geomorphological impact assessment: a functional approach

    NARCIS (Netherlands)

    Wolfert, H.P.

    1995-01-01

    An integral method for assessing geomorphological landscape qualities is presented, to be used in environmental impact assessments. Five groups of landform functions are distinguished in the Netherlands, an area of low relief: orientation functions, information functions, ordering functions,

  7. Assessment of symbolic function in Mexican preschool children

    Directory of Open Access Journals (Sweden)

    N. R. Jiménez Barreto

    2013-04-01

    Full Text Available Development of symbolic function is an important psychological formation of pre-school age and reflects the possibility of the child to use signs and symbols in a conscious way. Assessment of symbolic function can be used as one of preparation for school indicators. The objective of the present study is to characterize the level of symbolic function development in Mexican pre-school children. 59 children were included in the study. The ages of the children were between 5 and 6 years and all of them belonged to sub-urban pre-school institution. All 59 children participated in this study for the first time. Our assessment consisted of specific tasks with symbolic means on materialized, perceptive and verbal levels. Each child was tested individually. Results showed an insufficient development of the symbolic function in all evaluated children. More than 78% of the children showed difficulties during performance in the tasks of assessment; their drawings were undifferentiated and had few essential characteristics. The obtained results show the necessity to implement developmental strategies in order to guarantee the formation of the ability of constant conscious sage of symbolic means at the end of pre-school age.

  8. An automated system for assessing cognitive function in any environment

    Science.gov (United States)

    Wesnes, Keith A.

    2005-05-01

    The Cognitive Drug Research (CDR) computerized assessment system has been in use in worldwide clinical trials for over 20 years. It is a computer based system which assesses core aspects of human cognitive function including attention, information, working memory and long-term memory. It has been extensively validated and can be performed by a wide range of clinical populations including patients with various types of dementia. It is currently in worldwide use in clinical trials to evaluate new medicines, as well as a variety of programs involving the effects of age, stressors illnesses and trauma upon human cognitive function. Besides being highly sensitive to drugs which will impair or improve function, its utility has been maintained over the last two decades by constantly increasing the number of platforms upon which it can operate. Besides notebook versions, the system can be used on a wrist worn device, PDA, via tht telephone and over the internet. It is the most widely used automated cognitive function assessment system in worldwide clinical research. It has dozens of parallel forms and requires little training to use or administer. The basic development of the system wil be identified, and the huge databases (normative, patient population, drug effects) which have been built up from hundreds of clinical trials will be described. The system is available for use in virtually any environment or type of trial.

  9. Development of an assessment of functioning scale for prison environments.

    Science.gov (United States)

    Shelton, Deborah; Wakai, Sara

    2015-01-01

    This paper reports the development of a global assessment of functioning (GAF), modified from the DSM Axis V GAF for the prison environment. Focus groups, which were conducted with 36 correctional officers and clinicians in two prisons, provided descriptions of behavior in prison settings to re-align the GAF scale. Face validity was established. It was found that Habitation/Behavior, Social, and Symptoms emerged as important domains of functioning in prison. Gender differences were noted with regard to cleanliness, relationships and coping strategies. The cut-off score was identified at a score where offenders were unable to participate in a disciplinary process due to their mental illness. The structure of prison alters human functioning, requiring different assessment language and ratings to measure perceived behavioral norms and/or expectations. Front-line staff need the ability to observe and communicate behavioral changes quickly and accurately in a prison environment without undue burden upon their workload. This assessment was modified by front-line staff specifically for the prison environment to document quick and frequent assessments of observed changes over time in the offender population.

  10. Comparing the Selected Transfer Functions and Local Optimization Methods for Neural Network Flood Runoff Forecast

    Directory of Open Access Journals (Sweden)

    Petr Maca

    2014-01-01

    Full Text Available The presented paper aims to analyze the influence of the selection of transfer function and training algorithms on neural network flood runoff forecast. Nine of the most significant flood events, caused by the extreme rainfall, were selected from 10 years of measurement on small headwater catchment in the Czech Republic, and flood runoff forecast was investigated using the extensive set of multilayer perceptrons with one hidden layer of neurons. The analyzed artificial neural network models with 11 different activation functions in hidden layer were trained using 7 local optimization algorithms. The results show that the Levenberg-Marquardt algorithm was superior compared to the remaining tested local optimization methods. When comparing the 11 nonlinear transfer functions, used in hidden layer neurons, the RootSig function was superior compared to the rest of analyzed activation functions.

  11. The impact of slow graft function on graft outcome is comparable to delayed graft function in deceased donor kidney transplantation.

    Science.gov (United States)

    Shin, Jung-Ho; Koo, Eun Hee; Ha, Sung Hae; Park, Ji Hyeon; Jang, Hye Ryoun; Lee, Jung Eun; Park, Jae-Berm; Kim, Sung Joo; Jung, Sin-Ho; Kim, Yoon-Goo; Kim, Dae Joong; Oh, Ha Young; Huh, Wooseong

    2016-03-01

    Slow graft function (SGF) can influence overall prognosis in patients receiving deceased donor kidney transplantation (DKT). However, the impact of SGF on renal function remains uncertain. We investigated retrospectively renal function in cases with SGF compared with early graft function (EGF) and delayed graft function (DGF). Renal function after transplantation was analyzed in 199 patients who underwent DKT. Patients were classified into 130 (65.3 %) cases with EGF, 27 (13.6 %) cases with SGF, 6 (3.0 %) cases with DGF and one dialysis (DGF1), and 36 (18.1 %) cases with DGF and two or more dialyses (DGF2). The 1-year estimated glomerular filtration rate (eGFR) in the SGF group was lower than that in the EGF group (P = 0.027), but the rate of eGFR decline did not differ between the groups. The risk factors for renal function were evaluated using the area under the eGFR curve over 3 years (AUCeGFR). Donor age was negatively, and recipient age and the number of HLA matches were positively correlated with the AUCeGFR (all P DKT. Moreover, it was comparable to DGF. Efforts should be dedicated to minimizing the development of SGF and DGF.

  12. A randomised trial comparing the effect of exercise training and weight loss on microvascular function in coronary artery disease

    DEFF Research Database (Denmark)

    Olsen, Rasmus Huan; Pedersen, Lene Rørholm; Jürs, Anders

    2015-01-01

    BACKGROUND: Coronary microvascular function is associated with outcome and is reduced in coronary artery disease (CAD) and obesity. We compared the effect of aerobic interval training (AIT) and weight loss on coronary flow reserve (CFR) and peripheral vascular function in revascularised obese CAD...... patients. METHODS AND RESULTS: Seventy non-diabetic patients (BMI 28-40 kg × m(-2), age 45-75 years) were randomised to 12 weeks' AIT (three weekly sessions lasting 38 min with ≈ 16 min at 85-90% of VO2peak) or low energy diet (LED, 800-1000 kcal/day). Per protocol adherence was defined by training......-attendance ≥ 60% and weight loss ≥ 5%, respectively. CFR was assessed by Doppler echocardiography of the LAD. Peripheral vascular function was assessed by arterial tonometry as reactive hyperaemia index (RHI) and augmentation index. Most participants had impaired CFR with a mean CFR of 2.38 (SD 0.59). Twenty...

  13. Assessment of soil contamination--a functional perspective.

    Science.gov (United States)

    van Straalen, Nico M

    2002-01-01

    In many industrialized countries the use of land is impeded by soil pollution from a variety of sources. Decisions on clean-up, management or set-aside of contaminated land are based on various considerations, including human health risks, but ecological arguments do not have a strong position in such assessments. This paper analyses why this should be so, and what ecotoxicology and theoretical ecology can improve on the situation. It seems that soil assessment suffers from a fundamental weakness, which relates to the absence of a commonly accepted framework that may act as a reference. Soil contamination can be assessed both from a functional perspective and a structural perspective. The relationship between structure and function in ecosystems is a fundamental question of ecology which receives a lot of attention in recent literature, however, a general concept that may guide ecotoxicological assessments has not yet arisen. On the experimental side, a good deal of progress has been made in the development and standardized use of terrestrial model ecosystems (TME). In such systems, usually consisting of intact soil columns incubated in the laboratory under conditions allowing plant growth and drainage of water, a compromise is sought between field relevance and experimental manageability. A great variety of measurements can be made on such systems, including microbiological processes and activities, but also activities of the decomposer soil fauna. I propose that these TMEs can be useful instruments in ecological soil quality assessments. In addition a "bioinformatics approach" to the analysis of data obtained in TME experiments is proposed. Soil function should be considered as a multidimensional concept and the various measurements can be considered as indicators, whose combined values define the "normal operating range" of the system. Deviations from the normal operating range indicate that the system is in a condition of stress. It is hoped that more work

  14. Functional Behavior Assessments and Behavior Intervention Plans: Legal Requirements and Professional Recommendations

    Science.gov (United States)

    Collins, Lauren W.; Zirkel, Perry A.

    2017-01-01

    Functional behavior assessments (FBAs) and behavior intervention plans (BIPs) are critical components in the education of students with, or at risk for, emotional disturbance (ED). The purpose of this article is to compare the legal requirements with the professional requirements for FBAs and BIPs. The comparison is first according to the…

  15. Researching Civil Remedies for International Corruption: The Choice of the Functional Comparative Method

    NARCIS (Netherlands)

    A.O. Makinwa (Abiola)

    2009-01-01

    textabstractThis paper motivates the choice of the functional comparative method to research the issue of civil remedies for international corruption. It shows how the social, economic and political factors that have shaped the normative context of the research question point to the functional

  16. Assessment of the function of the nervus intermedius by means of functional salivary gland-scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, J.P.; Bertram, G.; Moedder, G.

    1982-01-01

    Using functional scintigraphy of the salivary glands, the function of the nervus intermedius can be assessed by estimating excretory quotients for both submandibular glands. This method is preferred to the standard salivation test method of Magielski and Blatt, despite a minimal exposure of the patient to radiation from the injected Natriumpertechnetat. The technical course of this investigation, along with the indications for its use, will be presented.

  17. A Comparative Study of Retinal Function in Rabbits after Panretinal Selective Retina Therapy versus Conventional Panretinal Photocoagulation

    Directory of Open Access Journals (Sweden)

    Young Gun Park

    2015-01-01

    Full Text Available Purpose. This study evaluates functional changes in electroretinographic findings after selective retina therapy (SRT compared to panretinal photocoagulation (PRP in rabbits. Methods. The right eyes of 12 Chinchilla rabbits received 200 laser treatment spots. The right eyes of six rabbits received SRT (SRT group, whereas the other six animals were treated using PRP on the right eye (PRP group. The eyes were investigated using full-field ERG 1 hour and 3 weeks after treatment. Histologic exam to assess the tissue response of lasers was performed on 3 weeks. Results. No significant changes in the mean ROD or CR b-wave amplitudes of the SRT lesions were evident, compared to baseline, 1 h after laser treatment (p=0.372 and 0.278, resp.. In addition, the OPs and 30 Hz flickers of the SRT lesions were not significantly altered (p=0.17 and 0.243, resp.. At 3 weeks, similar results were found. Comparing the two groups, the ROD b-wave amplitude was reduced in the PRP and SRT groups to 60.04±4.2% and 92.32±6.43% of baseline (p<0.001. Histologically, there was no visible photoreceptor alterations on week 3. Conclusions. SRT in rabbit eyes induced less functional loss than PRP in both rod-mediated retinal function and cone-mediated retinal function. In addition, SRT irradiated eyes had no functional loss compared to its control.

  18. Assessing Cognitive Function in Older Adults Using a Videoconference Approach

    OpenAIRE

    Teresa Costa Castanho; Liliana Amorim; Pedro Silva Moreira; José Mariz; Joana Almeida Palha; Nuno Sousa; Nadine Correia Santos

    2016-01-01

    Background: The use of communication technologies is an emerging trend in healthcare and research. Despite efficient, reliable and accurate neuropsychological batteries to evaluate cognitive performance in-person, more diverse and less expensive and time consuming solutions are needed. Here we conducted a pilot study to determine the applicability of a videoconference (VC, Skype (R)) approach to assess cognitive function in older adults, using The Telephone Interview for Cognitive Status-Modi...

  19. Predictive assessment of models for dynamic functional connectivity

    DEFF Research Database (Denmark)

    Nielsen, Søren Føns Vind; Schmidt, Mikkel Nørgaard; Madsen, Kristoffer Hougaard

    2018-01-01

    represent functional brain networks as a meta-stable process with a discrete number of states; however, there is a lack of consensus on how to perform model selection and learn the number of states, as well as a lack of understanding of how different modeling assumptions influence the estimated state......In neuroimaging, it has become evident that models of dynamic functional connectivity (dFC), which characterize how intrinsic brain organization changes over time, can provide a more detailed representation of brain function than traditional static analyses. Many dFC models in the literature...... dynamics. To address these issues, we consider a predictive likelihood approach to model assessment, where models are evaluated based on their predictive performance on held-out test data. Examining several prominent models of dFC (in their probabilistic formulations) we demonstrate our framework...

  20. Nitroglycerine, esmolol and dexmedetomidine for induced hypotension during functional endoscopic sinus surgery: A comparative evaluation

    Directory of Open Access Journals (Sweden)

    Sukhminder Jit Singh Bajwa

    2016-01-01

    Full Text Available Background and Aim: Induced hypotension limits intra-operative blood loss to provide better visibility of the surgical field and diminishes the incidence of major complications during functional endoscopic sinus surgery (FESS. We aimed at comparing nitroglycerine, esmolol and dexmedetomidine for inducing controlled hypotension in patients undergoing FESS. Material and Methods: One hundred and fifty American Society of Anesthesiologists physical status I or II adult patients undergoing FESS under general anesthesia were randomly allocated to three groups of 50 patients each. Group E received esmolol in a loading and maintenance dose of 1 mg/kg over 1 min and 0.5-1.0 mg/kg/h, respectively. Group D received a loading dose of dexmedetomidine 1 μg/kg over 10 min followed by an infusion 0.5-1.0 μg/kg/h, and group N received nitroglycerine infusion at a dose of 0.5-2 μg/kg/min so as to maintain mean arterial pressure (MAP between 60 and 70 mmHg in all the groups. The visibility of the surgical field was assessed by surgeon using Fromme and Boezaart scoring system. Hemodynamic variables, total intra-operative fentanyl consumption, emergence time and time to first analgesic request were recorded. Any side-effects were noted. The postoperative sedation was assessed using Ramsay Sedation Score. Result: The desired MAP (60-70 mmHg could be achieved in all the three study groups albeit with titration of study drugs during intra-operative period. No significant intergroup difference was observed in Fromme′s score during the intra-operative period. The mean total dose of fentanyl (μg/kg used was found to be significantly lower in group D compared to groups E and N (1.2 ± 0.75 vs. 3.6 ± 1.3 and 2.9 ± 1.1 respectively. The mean heart rate was significantly lower in group D compared to groups E and N at all times of measurement (P < 0.05. The MAP was found to be significantly lower in group D compared to groups E and N after infusion of study drugs

  1. Comparison of left ventricular function assessment between echocardiography and MRI in Duchenne muscular dystrophy

    Energy Technology Data Exchange (ETDEWEB)

    Buddhe, Sujatha; Lewin, Mark; Olson, Aaron; Soriano, Brian D. [University of Washington School of Medicine and Seattle Children' s Hospital, Division of Cardiology, Department of Pediatrics, Seattle, WA (United States); Ferguson, Mark [University of Washington School of Medicine and Seattle Children' s Hospital, Department of Radiology, Seattle, WA (United States)

    2016-09-15

    Cardiomyopathy in Duchenne muscular dystrophy (DMD) is associated with death in approximately 40% of patients. Echocardiography is routinely used to assess left ventricular (LV) function; however, it has limitations in these patients. We compared echocardiographic measures of cardiac function assessment to cardiac MRI. We included children and young adults with DMD who had MRI performed between January 2010 and July 2015. We measured echocardiographic and MRI parameters of function assessment, including strain. Presence of late gadolinium enhancement (LGE) was assessed by MRI. Subjects were divided into two groups based on MRI left ventricular ejection fraction (LVEF): group I, LVEF ≥55% and group II, LVEF <55%. We included 41 studies in 33 subjects, with 25 in group I and 16 in group II. Mean age of subjects was 13.6 ± 2.8 years and mean duration between echocardiogram and MRI was 7.6 ± 4.1 months. Only 8 of 16 (50%) patients in group II had diminished function on echocardiogram. Echocardiographic images were suboptimal in 16 subjects (39%). Overall, echocardiographic parameters had weak correlation with MRI-derived ejection fraction percentage. MRI-derived myocardial strain assessment has better correlation with MRI ejection fraction as compared to echocardiography-derived strain parameters. Echocardiography-based ventricular functional assessment has weak correlation with MRI parameters in children and young adults with Duchenne muscular dystrophy. While this correlation improves in the subset of subjects with adequate echocardiographic image quality, it remains modest and potentially suboptimal for clinical management. Accordingly, we conclude that MRI should be performed routinely and early in children with DMD, not only for LGE imaging but also for functional assessment. (orig.)

  2. Comparison of left ventricular function assessment between echocardiography and MRI in Duchenne muscular dystrophy

    International Nuclear Information System (INIS)

    Buddhe, Sujatha; Lewin, Mark; Olson, Aaron; Soriano, Brian D.; Ferguson, Mark

    2016-01-01

    Cardiomyopathy in Duchenne muscular dystrophy (DMD) is associated with death in approximately 40% of patients. Echocardiography is routinely used to assess left ventricular (LV) function; however, it has limitations in these patients. We compared echocardiographic measures of cardiac function assessment to cardiac MRI. We included children and young adults with DMD who had MRI performed between January 2010 and July 2015. We measured echocardiographic and MRI parameters of function assessment, including strain. Presence of late gadolinium enhancement (LGE) was assessed by MRI. Subjects were divided into two groups based on MRI left ventricular ejection fraction (LVEF): group I, LVEF ≥55% and group II, LVEF <55%. We included 41 studies in 33 subjects, with 25 in group I and 16 in group II. Mean age of subjects was 13.6 ± 2.8 years and mean duration between echocardiogram and MRI was 7.6 ± 4.1 months. Only 8 of 16 (50%) patients in group II had diminished function on echocardiogram. Echocardiographic images were suboptimal in 16 subjects (39%). Overall, echocardiographic parameters had weak correlation with MRI-derived ejection fraction percentage. MRI-derived myocardial strain assessment has better correlation with MRI ejection fraction as compared to echocardiography-derived strain parameters. Echocardiography-based ventricular functional assessment has weak correlation with MRI parameters in children and young adults with Duchenne muscular dystrophy. While this correlation improves in the subset of subjects with adequate echocardiographic image quality, it remains modest and potentially suboptimal for clinical management. Accordingly, we conclude that MRI should be performed routinely and early in children with DMD, not only for LGE imaging but also for functional assessment. (orig.)

  3. A Comparison of Functional Behavior Assessment Methodologies with Young Children: Descriptive Methods and Functional Analysis

    Science.gov (United States)

    Alter, Peter J.; Conroy, Maureen A.; Mancil, G. Rich; Haydon, Todd

    2008-01-01

    The use of functional behavior assessment (FBA) to guide the development of behavior intervention plans continues to increase since they were first mandated in IDEA (Individuals with Disabilities Education Act Amendments of 1997, 20 U.S.C. Section 1400 et seq, 1997). A variety of indirect and direct instruments have been developed to facilitate…

  4. Towards a systemic functional model for comparing forms of discourse in academic writing Towards a systemic functional model for comparing forms of discourse in academic writing

    Directory of Open Access Journals (Sweden)

    Meriel Bloor

    2008-04-01

    Full Text Available This article reports on research into the variation of texts across disciplines and considers the implications of this work for the teaching of writing. The research was motivated by the need to improve students’ academic writing skills in English and the limitations of some current pedagogic advice. The analysis compares Methods sections of research articles across four disciplines, including applied and hard sciences, on a cline, or gradient, termed slow to fast. The analysis considers the characteristics the texts share, but more importantly identifies the variation between sets of linguistic features. Working within a systemic functional framework, the texts are analysed for length, sentence length, lexical density, readability, grammatical metaphor, Thematic choice, as well as various rhetorical functions. Contextually relevant reasons for the differences are considered and the implications of the findings are related to models of text and discourse. Recommendations are made for developing domain models that relate clusters of features to positions on a cline. This article reports on research into the variation of texts across disciplines and considers the implications of this work for the teaching of writing. The research was motivated by the need to improve students’ academic writing skills in English and the limitations of some current pedagogic advice. The analysis compares Methods sections of research articles across four disciplines, including applied and hard sciences, on a cline, or gradient, termed slow to fast. The analysis considers the characteristics the texts share, but more importantly identifies the variation between sets of linguistic features. Working within a systemic functional framework, the texts are analysed for length, sentence length, lexical density, readability, grammatical metaphor, Thematic choice, as well as various rhetorical functions. Contextually relevant reasons for the differences are considered

  5. Association between central obesity and executive function as assessed by stroop task performance: A functional near-infrared spectroscopy study

    Directory of Open Access Journals (Sweden)

    Zhangyan Deng

    2018-01-01

    Full Text Available Recent studies have suggested a link between executive function (EF and obesity. Studies often adopt body mass index (BMI, which reflects the distribution of subcutaneous fat, as the sole marker of obesity; however, BMI is inappropriate to distinguish central obesity, which indicates the centralized distribution of visceral fat. Visceral fat compared with subcutaneous fat represents greater relative lipid turnover and may increase the risk of cognitive decline in older adults. However, the relationship between EF and central obesity is largely unknown, particularly in young adults. Therefore, we used waist circumference (WC as a marker of central obesity and investigated different sensitivities between BMI and WC in the brain function. A total of 26 healthy young adults (aged 18–25 years; 42% female underwent functional near-infrared spectroscopy assessments. EF was assessed using the Stroop task, which is a classical measurement of EF. A significant Stroop effect was observed in the behavioral and hemodynamic data. In addition, we observed that behavioral interference on the Stroop task varied much more in subjects with higher BMI and WC than those subjects with lower. Elevated BMI and WC were associated with a decreased hemodynamic response during the Stroop task specifically in the prefrontal cortex (PFC. Compared to BMI, WC was more closely connected with inhibitory control and revealed right lateralized PFC activation. Our findings suggest that WC is a reliable indicator of brain function in young adults and propose a relationship between EF and central obesity.

  6. Functional Assessment and Injury Risk in a Professional Soccer Team

    Directory of Open Access Journals (Sweden)

    Pedro Gómez-Piqueras

    2017-01-01

    Full Text Available At the last World Conference on Sport and Physical Therapy celebrated in Bern (Switzerland, 2015, it was confirmed that the functional skills of an athlete are a very important variable to be considered in the recovery of an injury. On the other hand, its use as a predictive risk tool still lacks solid evidence. The purpose of this study was to determine whether a battery of functional tests (FPT could be used as a preliminary measure for the season in order to identify the injury risk in a professional soccer team in the Spanish Second Division B League. Fifty-two soccer players (ages of 25.3 ± 4.6 years, 10.33% ± 0.9% fat were functionally assessed during two seasons (2012–2013 and 2013–2014 and analyzed from an injury perspective. A total of 125 injuries were recorded. The sample was grouped based on the number of injuries and the required absence days. Except for the bipodal vertical jump (CMJ, none of the functional tests revealed differences among the groups. The correlation study between the functional condition and the suffered injuries did not show any significant results.

  7. Improving Assessment of Work Related Mental Health Function Using the Work Disability Functional Assessment Battery (WD-FAB).

    Science.gov (United States)

    Marfeo, Elizabeth E; Ni, Pengsheng; McDonough, Christine; Peterik, Kara; Marino, Molly; Meterko, Mark; Rasch, Elizabeth K; Chan, Leighton; Brandt, Diane; Jette, Alan M

    2018-03-01

    Purpose To improve the mental health component of the Work Disability Functional Assessment Battery (WD-FAB), developed for the US Social Security Administration's (SSA) disability determination process. Specifically our goal was to expand the WD-FAB scales of mood & emotions, resilience, social interactions, and behavioral control to improve the depth and breadth of the current scales and expand the content coverage to include aspects of cognition & communication function. Methods Data were collected from a random, stratified sample of 1695 claimants applying for the SSA work disability benefits, and a general population sample of 2025 working age adults. 169 new items were developed to replenish the WD-FAB scales and analyzed using factor analysis and item response theory (IRT) analysis to construct unidimensional scales. We conducted computer adaptive test (CAT) simulations to examine the psychometric properties of the WD-FAB. Results Analyses supported the inclusion of four mental health subdomains: Cognition & Communication (68 items), Self-Regulation (34 items), Resilience & Sociability (29 items) and Mood & Emotions (34 items). All scales yielded acceptable psychometric properties. Conclusions IRT methods were effective in expanding the WD-FAB to assess mental health function. The WD-FAB has the potential to enhance work disability assessment both within the context of the SSA disability programs as well as other clinical and vocational rehabilitation settings.

  8. Induced hypotension for functional endoscopic sinus surgery: A comparative study of dexmedetomidine versus esmolol

    Directory of Open Access Journals (Sweden)

    Tarek Shams

    2013-01-01

    Full Text Available Objective: A comparative study to evaluate the efficacy of dexmedetomidine as a hypotensive agent in comparison to esmolol in Functional Endoscopic Sinus Surgery (FESS. Methods: Forty patients ASA I or II scheduled for FESS were equally randomly assigned to receive either dexmedetomidine 1 μg/Kg over 10 min before induction of anesthesia followed by 0.4-0.8 μg/Kg/h infusion during maintenance (DEX group, or esmolol, loading dose 1mg/kg was infused over one min followed by 0.4-0.8 mg/kg/h infusion during maintenance (E group to maintain mean arterial blood pressure (MAP between (55-65 mmHg. General anesthesia was maintained with sevoflurane 2%-4%. The surgical field was assessed using Average Category Scale and average blood loss was calculated. Hemodynamic variables (MAP and HR; arterial blood gas analysis; plasma cortisol level; intraoperative fentanyl consumption; Emergence time and total recovery from anesthesia (Aldrete score ≥9 were recorded. Sedation score was determined at 15, 30, 60 min after tracheal extubation and time to first analgesic request was recorded. Result: Both DEX group and E group reached the desired MAP (55-65 mmHg with no intergroup differences in MAP or HR. The for the quality of the surgical filed in the range of MAP (55-65 mmHg were <=2 with no significant differences between group scores during hypotensive period. Mean intraoperative fentanyl consumption was significantly lower in DEX group than E group. Cortisol level showed no significant changes between or within groups. No significant changes were observed in arterial blood gases. Emergence time and time to achieve Aldrete score ≥9 were significantly lower in E group compared with DEX group. The sedation score were significantly lower in E group compared with DEX group at 15 and 30 minutes postoperatively. Time to first analgesic request was significantly longer in DEX group. Conclusion: Both dexmedetomidine or esmolol with sevoflurane are safe agents for

  9. Assessment of ventricular function by radionuclide ventriculography in hyperthyroidism

    International Nuclear Information System (INIS)

    Dong Weiyu; He Pinyu; Zhuang Weite

    1996-01-01

    Left ventricular(LV) and right ventricular(RV) function were determined using radionuclide ventriculography in 50 patients with hyperthyroidism. LVEF, LVPFR, SV of the hyperthyroidism group were decreased in comparison with the normal group (P<0.01), whereas CO of the hyperthyroidism patients were higher than that of normal (P<0.01). Except LVPER, the LVEF, SV had significant difference between two groups. Compared to normal group, RVEF, RVPER, RVPFR were also decreased (P<0.01). Besides 30 cases of the hyperthyroidism were examined by impedance cardiogram (ICG) and impedance pulmonary rheogram (IPR), all showed closely correlation with the parameters determined by ventriculography. There was the involvement of right ventricular function insufficiency, especially in ejection phase. When compared with pre-therapy, pos-therapy cases showed significant improvement in EF, PER, PFR of left and right ventricular

  10. Objective function for the environmental assessment of waste

    International Nuclear Information System (INIS)

    Toy, A.J.; Boegel, J.; Cohen, J.J.

    1976-01-01

    Various waste management systems were examined in order to determine what the environmental impacts might be and to rank the relative importance of those impacts. This examination determined that radiation dose to man was the most significant, and probably overriding, impact. This report describes methods of providing an objective function for dose to man. The search for an objective function began with a reading of Federal Regulations and the output of various standard setting councils and committees. Ample guidance was found on maximum allowable doses to individuals but no guidance on dose to large populations or criteria by which systems could be compared or optimized. Several other ways were postulated by which waste management systems could be evaluated besides maximum allowable dose to individuals. 0.1 man-rem per MW(e)-year was selected as the measure of system performance. This unit compares a rational estimate of population dose commitment with the concurrent benefit

  11. Subjective daytime functioning assessment in people with insomnia.

    Science.gov (United States)

    Grabowski, Karol; Nowicka-Sauer, Katarzyna; Zdrojewski, Tomasz; Rutkowski, Marcin; Bandosz, Piotr; Nowicki, Zbigniew

    2017-10-29

    The aim of this study was to assess the prevalence and severity of subjective daytime functioning impairment among people with insomnia complaints. Another goal was to establish its relationships with age, gender, type and duration of subjective insomnia. Study group consisted of NATPOL study participants - 2,413 people (1,245 women and 1,168 men) aged 18-79. We extracted group with declared insomnia complaints, consisting of 1,221 people (736 women and 485 men) aged 18-79. Data on insomnia symptoms characteristics, their duration and subjective functioning impairment were further analyzed. Functioning impairment was declared by 825 people (67.7% of those who declared subjective insomnia) and it was more common in women. It was most common among people with insomnia complaints lasting over two weeks - 72.4%. In people with symptoms lasting less than two weeks or for a few days it was 70.7% and 64.9% respectively. People with insomnia symptoms lasting over two weeks accounted for 20% of group with severe functioning impairment. For shorter duration of symptoms it was 8.6% and 6.9% respectively. Among people with mild functioning impairment, persons with symptoms lasting for a few days and less than two weeks were predominant - 32.5% and 35.3% respectively. In people aged 18-24 years mild functioning impairment was predominant (66.66%). Subjective daytime functioning impairment is common in people declaring insomnia symptoms. It is more common in women and its prevalence and intensity are greater in people with longer duration of sleep problems. Its prevalence is not correlated with age and it is the mildest in people aged 18-24.

  12. Comparative Human Health Impact Assessment of Engineered Nanomaterials in the Framework of Life Cycle Assessment.

    Science.gov (United States)

    Fransman, Wouter; Buist, Harrie; Kuijpers, Eelco; Walser, Tobias; Meyer, David; Zondervan-van den Beuken, Esther; Westerhout, Joost; Klein Entink, Rinke H; Brouwer, Derk H

    2017-07-01

    For safe innovation, knowledge on potential human health impacts is essential. Ideally, these impacts are considered within a larger life-cycle-based context to support sustainable development of new applications and products. A methodological framework that accounts for human health impacts caused by inhalation of engineered nanomaterials (ENMs) in an indoor air environment has been previously developed. The objectives of this study are as follows: (i) evaluate the feasibility of applying the CF framework for NP exposure in the workplace based on currently available data; and (ii) supplement any resulting knowledge gaps with methods and data from the life cycle approach and human risk assessment (LICARA) project to develop a modified case-specific version of the framework that will enable near-term inclusion of NP human health impacts in life cycle assessment (LCA) using a case study involving nanoscale titanium dioxide (nanoTiO 2 ). The intent is to enhance typical LCA with elements of regulatory risk assessment, including its more detailed measure of uncertainty. The proof-of-principle demonstration of the framework highlighted the lack of available data for both the workplace emissions and human health effects of ENMs that is needed to calculate generalizable characterization factors using common human health impact assessment practices in LCA. The alternative approach of using intake fractions derived from workplace air concentration measurements and effect factors based on best-available toxicity data supported the current case-by-case approach for assessing the human health life cycle impacts of ENMs. Ultimately, the proposed framework and calculations demonstrate the potential utility of integrating elements of risk assessment with LCA for ENMs once the data are available. © 2016 Society for Risk Analysis.

  13. The comparative and functional analysis of myth and ritual as constituent parts of a mythoritual religious

    Directory of Open Access Journals (Sweden)

    Ivan Davydov

    2013-02-01

    Full Text Available The author treats the problem of ritual studies as relevant to the study of religion. Mytho-ritual is a relatively new concept, unfamiliar to many specialists. The author tries to define this concept, trace its origin and essential characteristics, and finally, on the basis of all this, posit a link uniting myth and ritual. Importance is given to the functional analysis of ritual, highlighting the essential role of ritual and rite. The theories of the Bielefeld and Moscow schools, the theory of V. N. Toporov regarding religious ritual, and those regarding ritual and rite proposed by A. K. Baiburin and K. S. Saringulyan are examined. The author then proceeds to an analysis of the functions of myth and examines the theories of M. Eliade and the Cambridge School. Finally the author compares the various functions of myth and ritual and fi nds that the number of actual functions of myth proposed by Russian and foreign experts, sociologists, ethnologists and folklorists, is rather small and closer in number to that of the functions of religion rather than of ritual. The author enumerates 36 functions of ritual as compared to only 12 functions of myth and 24 functions of religion

  14. Electricity, health and the environment: Comparative assessment in support of decision making. Proceedings of a symposium

    International Nuclear Information System (INIS)

    1996-01-01

    The main objective of the Symposium was to enhance and strengthen information sharing and co-operation between interested and affected parties in the field of electricity demand analysis and supply planning, aiming at implementing sustainable policies in the power sector, taking into account economic, social, health and environmental aspects. To meet this objective, the Symposium sessions addressed the following topics: key issues in the decision making process; assessment of health and environmental impacts; integrated framework for comparative assessment; implementation of comparative assessment; country case studies; and comparative assessment in decision making. A closing round table focused on challenges for international co-operation aiming at implementation of sustainable electricity policies. In addition to the main sessions, poster presentations illustrated results from comparative assessment studies carried out in different countries, and software demonstration provided opportunities for participants to gain information about state of the art computer tools, databases and analytical models that are available for use in decision support studies. Refs, figs, tabs

  15. Comparative Approaches to Understanding the Relation Between Aging and Physical Function.

    Science.gov (United States)

    Justice, Jamie N; Cesari, Matteo; Seals, Douglas R; Shively, Carol A; Carter, Christy S

    2016-10-01

    Despite dedicated efforts to identify interventions to delay aging, most promising interventions yielding dramatic life-span extension in animal models of aging are often ineffective when translated to clinical trials. This may be due to differences in primary outcomes between species and difficulties in determining the optimal clinical trial paradigms for translation. Measures of physical function, including brief standardized testing batteries, are currently being proposed as biomarkers of aging in humans, are predictive of adverse health events, disability, and mortality, and are commonly used as functional outcomes for clinical trials. Motor outcomes are now being incorporated into preclinical testing, a positive step toward enhancing our ability to translate aging interventions to clinical trials. To further these efforts, we begin a discussion of physical function and disability assessment across species, with special emphasis on mice, rats, monkeys, and man. By understanding how physical function is assessed in humans, we can tailor measurements in animals to better model those outcomes to establish effective, standardized translational functional assessments with aging. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  16. Episodic memory and executive functioning in currently depressed patients compared to healthy controls.

    Science.gov (United States)

    Pauls, Franz; Petermann, Franz; Lepach, Anja Christina

    2015-01-01

    At present, little is still known about the link between depression, memory and executive functioning. This study examined whether there are memory-related impairments in depressed patients and whether the size of such deficits depends on the age group and on specific types of cognitive measures. Memory performances of 215 clinically depressed patients were compared to the data of a matched control sample. Regression analyses were performed to determine the extent to which executive dysfunctions contributed to episodic memory impairments. When compared with healthy controls, significantly lower episodic memory and executive functioning performances were found for depressed patients of all age groups. Effect sizes appeared to vary across different memory and executive functioning measures. The extent to which executive dysfunctions could explain episodic memory impairments varied depending on the type of measure examined. These findings emphasise the need to consider memory-related functioning of depressed patients in the context of therapeutic treatments.

  17. Neuropsychological assessment of language functions during functional magnetic resonance imaging: development of new tasks. Preliminary report.

    Science.gov (United States)

    Fersten, Ewa; Jakuciński, Maciej; Kuliński, Radosław; Koziara, Henryk; Mroziak, Barbara; Nauman, Paweł

    2011-01-01

    Due to the complex and extended cerebral organization of language functions, the brain regions crucial for speech and language, i.e. eloquent areas, have to be affected by neurooncological surgery. One of the techniques that may be helpful in pre-operative planning of the extent of tumour removal and estimating possible complications seems to be functional magnetic resonance imaging (fMRI). The aim of the study was to develop valid procedures for neuropsychological assessment of various language functions visualisable by fMRI in healthy individuals. In this fMRI study, 10 healthy (with no CNS pathology), right-handed volunteers aged 25-35 were examined using four tasks designed to measure different language functions, and one for short-term memory assessment. A 1.5-T MRI scanner performing ultrafast functional (EPI) sequences with 4-mm slice thickness and 1-mm interslice gap was used to detect the BOLD response to stimuli present-ed in a block design (30-second alternating blocks of activity and rest). The analyses used the SPM software running in a MATLAB environment, and the obtained data were interpreted by means of colour-coded maps superimposed on structural brain scans. For each of the tasks developed for particular language functions, a different area of increased neuronal activity was found. The differential localization of function-related neuronal activity seems interesting and the research worth continuing, since verbal communication failure may result from impairment of any of various language functions, and studies reported in the literature seem to focus on verbal expression only.

  18. Analytical Tools for Functional Assessment of Architectural Layouts

    Science.gov (United States)

    Bąkowski, Jarosław

    2017-10-01

    Functional layout of the building, understood as a layout or set of the facility rooms (or groups of rooms) with a system of internal communication, creates an environment and a place of mutual relations between the occupants of the object. Achieving optimal (from the occupants’ point of view) spatial arrangement is possible through activities that often go beyond the stage of architectural design. Adopted in the architectural design, most often during trial and error process or on the basis of previous experience (evidence-based design), functional layout is subject to continuous evaluation and dynamic changing since the beginning of its use. Such verification of the occupancy phase allows to plan future, possible transformations, as well as to develop model solutions for use in other settings. In broader terms, the research hypothesis is to examine whether and how the collected datasets concerning the facility and its utilization can be used to develop methods for assessing functional layout of buildings. In other words, if it is possible to develop an objective method of assessing functional layouts basing on a set of buildings’ parameters: technical, technological and functional ones and whether the method allows developing a set of tools enhancing the design methodology of complex functional objects. By linking the design with the construction phase it is possible to build parametric models of functional layouts, especially in the context of sustainable design or lean design in every aspect: ecological (by reducing the property’s impact on environment), economic (by optimizing its cost) and social (through the implementation of high-performance work environment). Parameterization of size and functional connections of the facility become part of the analyses, as well as the element of model solutions. The “lean” approach means the process of analysis of the existing scheme and consequently - finding weak points as well as means for eliminating these

  19. Assessment of derelict soil quality: Abiotic, biotic and functional approaches.

    Science.gov (United States)

    Vincent, Quentin; Auclerc, Apolline; Beguiristain, Thierry; Leyval, Corinne

    2018-02-01

    The intensification and subsequent closing down of industrial activities during the last century has left behind large surfaces of derelict lands. Derelict soils have low fertility, can be contaminated, and many of them remain unused. However, with the increasing demand of soil surfaces, they might be considered as a resource, for example for non-food biomass production. The study of their physico-chemical properties and of their biodiversity and biological activity may provide indications for their potential re-use. The objective of our study was to investigate the quality of six derelict soils, considering abiotic, biotic, and functional parameters. We studied (i) the soil bacteria, fungi, meso- and macro-fauna and plant communities of six different derelict soils (two from coking plants, one from a settling pond, two constructed ones made from different substrates and remediated soil, and an inert waste storage one), and (ii) their decomposition function based on the decomposer trophic network, enzyme activities, mineralization activity, and organic pollutant degradation. Biodiversity levels in these soils were high, but all biotic parameters, except the mycorrhizal colonization level, discriminated them. Multivariate analysis showed that biotic parameters co-varied more with fertility proxies than with soil contamination parameters. Similarly, functional parameters significantly co-varied with abiotic parameters. Among functional parameters, macro-decomposer proportion, enzyme activity, average mineralization capacity, and microbial polycyclic aromatic hydrocarbon degraders were useful to discriminate the soils. We assessed their quality by combining abiotic, biotic, and functional parameters: the compost-amended constructed soil displayed the highest quality, while the settling pond soil and the contaminated constructed soil displayed the lowest. Although differences among the soils were highlighted, this study shows that derelict soils may provide a

  20. Brief debrisoquin administration to assess central dopaminergic function in children.

    Science.gov (United States)

    Riddle, M A; Shaywitz, B A; Leckman, J F; Anderson, G M; Shaywitz, S E; Hardin, M T; Ort, S I; Cohen, D J

    1986-03-17

    Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration resulted in marked reductions in pHVA in each of six patients studied. In five of the six patients, post-debrisoquin pHVA levels remained relatively stable over the six-hour period of observation. No significant cardiovascular or behavioral side effects of debrisoquin were observed. The brief debrisoquin administration method appears to be a safe, simple, and potentially valid peripheral technique for evaluating aspects of central dopaminergic function in children with neuropsychiatric disorders. Additional work is needed to further establish this method's validity and reliability.

  1. Cine-oesophago-gastroscintigraphy: assessment of digestive function in paediatrics

    Energy Technology Data Exchange (ETDEWEB)

    Guillet, J. (Hopital Pellegrin, 33 - Bordeaux (France))

    1984-05-15

    Cine-oesophago-gastroscintigraphy (COGS) can assess structure and function of the oesophagogastrointestinal tract. With this non-invasive method, the dosimetry is very low and quantification is easy. Milk or water labelled by sup(99m)Tc sulfocolloids are drunk by the patient. The transit is continuously monitored by a gamma camera and a computer. The esophageal transit time is useful in studying impairment of peristaltic motion. Fistula, diverticula and stenosis are easily detected. The sensitivity of this technique for the search of gastroesophageal reflux is as great as pH-metry. The quantification is of great interest to assess the severity of the reflux and to measure treatment efficacity. Slow rates of gastric emptying are associated with some of the reflux, and pyloric stenosis. Pulmonary contamination can be discovered in patients with gastro oesophageal reflux.

  2. Use of comparative assessment framework for comparison of geological nuclear waste and CO2 disposal technologies

    Energy Technology Data Exchange (ETDEWEB)

    Streimikiene, Dalia

    2010-09-15

    Comparative assessment of few future energy and climate change mitigation options for Lithuania in 2020 performed indicated that nuclear and combined cycle gas turbine technologies are very similar energy options in terms of costs taking into account GHG emission reduction costs. Comparative assessment of these energy options requires evaluation of the potentials and costs for geological CO2 and nuclear waste storage as the main uncertainties in comparative assessment of electricity generation technologies are related with these back-end technologies. The paper analyses the main characteristics of possible geological storage of CO2 and NW options in Lithuania.

  3. Apparatus and Method for Assessing Vestibulo-Ocular Function

    Science.gov (United States)

    Shelhamer, Mark J. (Inventor)

    2015-01-01

    A system for assessing vestibulo-ocular function includes a motion sensor system adapted to be coupled to a user's head; a data processing system configured to communicate with the motion sensor system to receive the head-motion signals; a visual display system configured to communicate with the data processing system to receive image signals from the data processing system; and a gain control device arranged to be operated by the user and to communicate gain adjustment signals to the data processing system.

  4. Functional neuroimaging in the assessment of cerebral ischaemia

    International Nuclear Information System (INIS)

    Sartor, K.; Heiland, S.

    1997-01-01

    Cerebral infarct causes over 170, 000 deaths per year in the United States. Recent developments in neuroimaging are providing an insight into focal cerebral ischaemia, including its pathophysiology and the area of brain at risk. Perfusion-weighted magnetic resonance (MR) allows evaluation of the blood supply to the ischaemic area, and diffusion-weighted MR permits assessment of tissue damage. Although both functional imaging techniques require some refinement, it is likely that they will soon become part of the normal clinical routine and allow accurate characterisation of pathology. It is expected that this may eventually lead to the development of new treatments. (orig.)

  5. Physiologically assessed hot flashes and endothelial function among midlife women.

    Science.gov (United States)

    Thurston, Rebecca C; Chang, Yuefang; Barinas-Mitchell, Emma; Jennings, J Richard; von Känel, Roland; Landsittel, Doug P; Matthews, Karen A

    2017-08-01

    Hot flashes are experienced by most midlife women. Emerging data indicate that they may be associated with endothelial dysfunction. No studies have tested whether hot flashes are associated with endothelial function using physiologic measures of hot flashes. We tested whether physiologically assessed hot flashes were associated with poorer endothelial function. We also considered whether age modified associations. Two hundred seventy-two nonsmoking women reporting either daily hot flashes or no hot flashes, aged 40 to 60 years, and free of clinical cardiovascular disease, underwent ambulatory physiologic hot flash and diary hot flash monitoring; a blood draw; and ultrasound measurement of brachial artery flow-mediated dilation to assess endothelial function. Associations between hot flashes and flow-mediated dilation were tested in linear regression models controlling for lumen diameter, demographics, cardiovascular disease risk factors, and estradiol. In multivariable models incorporating cardiovascular disease risk factors, significant interactions by age (P hot flashes (beta [standard error] = -2.07 [0.79], P = 0.01), and more frequent physiologic hot flashes (for each hot flash: beta [standard error] = -0.10 [0.05], P = 0.03, multivariable) were associated with lower flow-mediated dilation. Associations were not accounted for by estradiol. Associations were not observed among the older women (age 54-60 years) or for self-reported hot flash frequency, severity, or bother. Among the younger women, hot flashes explained more variance in flow-mediated dilation than standard cardiovascular disease risk factors or estradiol. Among younger midlife women, frequent hot flashes were associated with poorer endothelial function and may provide information about women's vascular status beyond cardiovascular disease risk factors and estradiol.

  6. FUNCTIONAL ASSESSMENT OF OLDER OBESE PATIENTS CANDIDATES FOR BARIATRIC SURGERY

    Directory of Open Access Journals (Sweden)

    Denis PAJECKI

    2014-03-01

    Full Text Available Context Obesity in the elderly is associated with exacerbation of functional decline (dependency, that occurs with aging, because of decreased muscle mass and strength, and increased joint dysfunction. Consequently, there is progressive loss of independence, autonomy, chronic pain and impaired quality of life. The weight loss can bring benefits in all these aspects, especially when accompanied by exercises. Elderly patients with morbid obesity may be submitted to surgical treatment, taking into account that the massive weight loss, eventually caused by bariatric surgery, may exacerbate the loss of muscle mass and nutritional complications that may bring harm to the overall health and quality of life of these patients. The functional assessment of elderly patients, candidates for bariatric surgery and the extent to which surgery can bring benefits to the patients, in the field of functionality, has still to be determined. Objective To describe profile functionality in obese elderly referred to a bariatric surgery program. Methods Patients with age ≥60 and BMI ≥35 underwent comprehensive geriatric assessment that evaluates co morbidities, medication use, ability to perform basic activities of daily living and instrumental activities of daily living, and the “Timedupandgo” test to evaluate mobility, whose cut-off point was ≤10 seconds. Statistical analysis was performed in order to see if there is a positive correlation of dependency with BMI and age (over or under 65 years. Results Forty subjects have completed evaluation. The mean age was 64.1 years (60-72 and 75% were women. They had an average weight of 121.1 kg (72.7-204 and a mean BMI of 47.2 kg/m2 (35.8-68.9. 16 patients (40% have shown dependency for activities of daily living, 19 (47,5% for instrumental activities of daily living and 20 patients (50% had a “Timedupandgo” test over 10 seconds. Statistical analysis (t-Student, Mann-Whitney, Binary Logistic Regression has shown

  7. Comparative Study of Entanglement and Wigner Function for Multi-Qubit GHZ-Squeezed State

    Science.gov (United States)

    Siyouri, Fatima-Zahra

    2017-12-01

    In this paper we address the possibility of using the Wigner function to capture the quantum entanglement present in a multi-qubit system. For that purpose, we calculate both the degree of entanglement and the Wigner function for mixed tripartite squeezed states of Greenberger-Horne-Zeilinger (GHZ) type then we compare their behaviors. We show that the role of Wigner function in detecting and quantifying bipartite quantum correlation [Int. J. Mod. Phys. B 30 (2016) 1650187] may be generalized to the multipartite case.

  8. Comparative Evaluation of Functional Properties of Some Commonly Used Cereal and Legume Flours and Their Blends

    Directory of Open Access Journals (Sweden)

    Haq Nawaz

    2015-12-01

    Full Text Available Functional properties such as protein solubility, swelling capacity, water holding capacity, gelling ability, bulk density and foaming capacity of flours of some commonly used cereals and legume (wheat, refined wheat, maize and chickpea and their blends were studied. Blends of flours were prepared by mixing equal proportions of selected floors. Statistically significant difference  in studied functional properties except bulk density was observed among cereal flours and their blends. Chickpea flour was found to possess comparatively high water holding capacity, protein solubility index and swelling capacity. The functional properties of maize and wheat flours were found to be improved when blended with chickpea. Chickpea flour and its blends with cereal flours were found to possess good functional score and suggested as favorable candidates for use in the preparation of viscous foods and bakery products. The data provide guidelines regarding the improvement in functional properties of economically favorable cereal flours.

  9. COMPAR

    International Nuclear Information System (INIS)

    Kuefner, K.

    1976-01-01

    COMPAR works on FORTRAN arrays with four indices: A = A(i,j,k,l) where, for each fixed k 0 ,l 0 , only the 'plane' [A(i,j,k 0 ,l 0 ), i = 1, isub(max), j = 1, jsub(max)] is held in fast memory. Given two arrays A, B of this type COMPAR has the capability to 1) re-norm A and B ind different ways; 2) calculate the deviations epsilon defined as epsilon(i,j,k,l): =[A(i,j,k,l) - B(i,j,k,l)] / GEW(i,j,k,l) where GEW (i,j,k,l) may be chosen in three different ways; 3) calculate mean, standard deviation and maximum in the array epsilon (by several intermediate stages); 4) determine traverses in the array epsilon; 5) plot these traverses by a printer; 6) simplify plots of these traverses by the PLOTEASY-system by creating input data blocks for this system. The main application of COMPAR is given (so far) by the comparison of two- and three-dimensional multigroup neutron flux-fields. (orig.) [de

  10. Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study

    Directory of Open Access Journals (Sweden)

    Raunsø Jakob

    2010-05-01

    Full Text Available Abstract Aim Studies of beta blockade in patients with type 2 diabetes have shown inferiority of metoprolol treatment compared to carvedilol on indices of insulin resistance. The aim of this study was to examine the effect of metoprolol versus carvedilol on endothelial function and insulin-stimulated endothelial function in patients with type 2 diabetes. Method 24 patients with type 2 diabetes were randomized to receive either 200 mg metoprolol succinate or 50 mg carvedilol daily. Endothelium-dependent vasodilation was assessed by using venous occlusion plethysmography with increasing doses of intra-arterial infusions of the agonist serotonin. Insulin-stimulated endothelial function was assessed after co-infusion of insulin for sixty minutes. Vaso-reactivity studies were done before and after the two-month treatment period. Results Insulin-stimulated endothelial function was deteriorated after treatment with metoprolol, the percentage change in forearm blood-flow was 60.19% ± 17.89 (at the highest serotonin dosages before treatment and -33.80% ± 23.38 after treatment (p = 0.007. Treatment with carvedilol did not change insulin-stimulated endothelial function. Endothelium-dependent vasodilation without insulin was not changed in either of the two treatment groups. Conclusion This study shows that vascular insulin sensitivity was preserved during treatment with carvedilol while blunted during treatment with metoprolol in patients with type 2 diabetes. Trial registration Current Controlled Trials NCT00497003

  11. Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study

    DEFF Research Database (Denmark)

    Kveiborg, Britt; Hermann, Thomas S; Major-Pedersen, Atheline

    2010-01-01

    -stimulated endothelial function in patients with type 2 diabetes. METHOD: 24 patients with type 2 diabetes were randomized to receive either 200 mg metoprolol succinate or 50 mg carvedilol daily. Endothelium-dependent vasodilation was assessed by using venous occlusion plethysmography with increasing doses of intra......AIM: Studies of beta blockade in patients with type 2 diabetes have shown inferiority of metoprolol treatment compared to carvedilol on indices of insulin resistance. The aim of this study was to examine the effect of metoprolol versus carvedilol on endothelial function and insulin...... with metoprolol, the percentage change in forearm blood-flow was 60.19% +/- 17.89 (at the highest serotonin dosages) before treatment and -33.80% +/- 23.38 after treatment (p = 0.007). Treatment with carvedilol did not change insulin-stimulated endothelial function. Endothelium-dependent vasodilation without...

  12. The meaning of results. Understanding comparative risk assessments of energy options

    International Nuclear Information System (INIS)

    Wilson, R.; Holland, M.; Rabl, A.; Dreicer, M.

    1999-01-01

    Results of comparative risk assessments can be used for a range of potential applications: choice and balance of technologies for strategic energy planning; choice of a new power plant; optimal dispatching of existing plants; optimization of regulations (emission limits, environmental quality objectives such as air quality limits, tradable permits, pollution taxes); accounting for climate change. When reporting the results of comparative risk assessment, a number of factors should be clear: precise nature of the energy system being assessed; what has been excluded from the analysis; sources of data used in assessment; assumptions that have been made; and what the analysts and other experts have regarded as the key sensitivities in the analysis. If all factors are addressed, the results of comparative risk assessment will prove to be an essential resource for making the best decisions about energy options and policies

  13. Functional valve assessment: the emerging role of cardiovascular magnetic resonance.

    Science.gov (United States)

    Shah, Dipan J

    2010-01-01

    The prevalence of valvular heart disease is increasing along with the life span of the population. In assessing individuals with valve disease, echocardiography is the primary imaging modality used by clinicians both for initial assessment and for longitudinal evaluation. Information regarding valve morphology and function, cardiac chamber size, wall thickness, ventricular function, and estimates of pulmonary artery pressures can be readily obtained and integrated to formulate an assessment of valve disease severity. In some instances, body habitus or the presence of coexisting lung disease may result in suboptimal acoustic windows on echocardiography, which may lead to technically difficult studies. Additionally, in some patients, information from clinical history and physical examination or other diagnostic tests may be discordant with echocardiographic findings. In these instances, there is a significant clinical role for cardiovascular magnetic resonance (CMR). The diagnostic capabilities of CMR have increased substantially over the past 20 years due to hardware and software advances. Today, CMR has a number of unique advantages over other imaging modalities - primarily, it provides a view of the entire heart without limitations from inadequate imaging windows or body habitus. Furthermore, CMR can obtain imaging data in any imaging plane prescribed by the scan operator, which makes it ideal for accurate investigation of all cardiac valves - aortic, mitral, pulmonic, and tricuspid. In addition, CMR for valve assessment is noninvasive, free of ionizing radiation, and in most instances does not require contrast administration. Since a comprehensive review of the role of CMR in all valve lesions is beyond the scope of this article, we will focus on the most common valvular indication for performance of clinical CMR techniques and an overview of selected validation and reproducibility studies. The objectives of a comprehensive CMR study for evaluating mitral

  14. Radionuclide assessment of renal function in patients with oncogynecological diseases

    International Nuclear Information System (INIS)

    Vlakhov, N.; Penkova, D.; Kovachev, A.

    1989-01-01

    Results of 131 I-hippuran (0.74 MBq) nephrography and 99m Tc DMCA (55.6 MBq) scintigraphy of the kidneys in 204 women from 21 to 75 years of age are analyzed. All patients were examined before and after treatment (surgical, radiation, hormonal). It was found that combined radiotherapy of patients with cervix uteri cancer and surgical treatment of patients with corpus uteri cancer resulted in aggravation of the secretory and excretory renal disorders, as compared to the pre-treatment state. It was not until after the second year of treatment that normal renal function was reestablished. Radionuclide methods furnish the opportunity both for early detection of renal function disorders and for their dynamic control and treatment. 1 tab., 4 refs

  15. COMPARATIVE ASSESSMENT OF NUCLEAR MAGNETIC RELAXATION CHARACTERISTICS OF SUNFLOWER AND RAPESEED LECITHIN

    OpenAIRE

    Lisovaya E. V.; Victorova E. P.; Agafonov O. S.; Kornen N. N.; Shahray T. A.

    2015-01-01

    The article presents a comparative assessment and peculiarities of nuclear magnetic relaxation characteristics of rapeseed and sunflower lecithin. It was established, that lecithin’s nuclear magnetic relaxation characteristics, namely, protons’ spin-spin relaxation time and amplitudes of nuclear magnetic relaxation signals of lecithin components, depend on content of oil’s fat acids and phospholipids, contained in the lecithin. Comparative assessment of protons’ spin-spin relaxation time of r...

  16. Functionalized mesoporous materials for adsorption and release of different drug molecules: A comparative study

    International Nuclear Information System (INIS)

    Wang Gang; Otuonye, Amy N.; Blair, Elizabeth A.; Denton, Kelley; Tao Zhimin; Asefa, Tewodros

    2009-01-01

    The adsorption capacity and release properties of mesoporous materials for drug molecules can be improved by functionalizing their surfaces with judiciously chosen organic groups. Functionalized ordered mesoporous materials containing various types of organic groups via a co-condensation synthetic method from 15% organosilane and by post-grafting organosilanes onto a pre-made mesoporous silica were synthesized. Comparative studies of their adsorption and release properties for various model drug molecules were then conducted. Functional groups including 3-aminopropyl, 3-mercaptopropyl, vinyl, and secondary amine groups were used to functionalize the mesoporous materials while rhodamine 6G and ibuprofen were utilized to investigate the materials' relative adsorption and release properties. The self-assembly of the mesoporous materials was carried out in the presence of cetyltrimethylammonium bromide (CTAB) surfactant, which produced MCM-41 type materials with pore diameters of ∼2.7-3.3 nm and moderate to high surface areas up to ∼1000 m 2 /g. The different functional groups introduced into the materials dictated their adsorption capacity and release properties. While mercaptopropyl and vinyl functionalized samples showed high adsorption capacity for rhodamine 6G, amine functionalized samples exhibited higher adsorption capacity for ibuprofen. While the diffusional release of ibuprofen was fitted on the Fickian diffusion model, the release of rhodamine 6G followed Super Case-II transport model. - Graphical abstract: The adsorption capacity and release properties of mesoporous materials for various drug molecules are tuned by functionalizing the surfaces of the materials with judiciously chosen organic groups. This work reports comparative studies of the adsorption and release properties of functionalized ordered mesoporous materials containing different hydrophobic and hydrophilic groups that are synthesized via a co-condensation and post-grafting methods for

  17. Peer Assessment in the Digital Age: A Meta-Analysis Comparing Peer and Teacher Ratings

    Science.gov (United States)

    Li, Hongli; Xiong, Yao; Zang, Xiaojiao; Kornhaber, Mindy L.; Lyu, Youngsun; Chung, Kyung Sun; Suen, Hoi K.

    2016-01-01

    Given the wide use of peer assessment, especially in higher education, the relative accuracy of peer ratings compared to teacher ratings is a major concern for both educators and researchers. This concern has grown with the increase of peer assessment in digital platforms. In this meta-analysis, using a variance-known hierarchical linear modelling…

  18. Life cycle assessment of a commercial rainwater harvesting system compared with a municipal water supply system

    Science.gov (United States)

    Building upon previously published life cycle assessment (LCA) methodologies, we conducted an LCA of a commercial rainwater harvesting (RWH) system and compared it to a municipal water supply (MWS) system adapted to Washington, D.C. Eleven life cycle impact assessment (LCIA) indi...

  19. Comparative study of popular objective functions for damping power system oscillations in multimachine system.

    Science.gov (United States)

    Islam, Naz Niamul; Hannan, M A; Shareef, Hussain; Mohamed, Azah; Salam, M A

    2014-01-01

    Power oscillation damping controller is designed in linearized model with heuristic optimization techniques. Selection of the objective function is very crucial for damping controller design by optimization algorithms. In this research, comparative analysis has been carried out to evaluate the effectiveness of popular objective functions used in power system oscillation damping. Two-stage lead-lag damping controller by means of power system stabilizers is optimized using differential search algorithm for different objective functions. Linearized model simulations are performed to compare the dominant mode's performance and then the nonlinear model is continued to evaluate the damping performance over power system oscillations. All the simulations are conducted in two-area four-machine power system to bring a detailed analysis. Investigated results proved that multiobjective D-shaped function is an effective objective function in terms of moving unstable and lightly damped electromechanical modes into stable region. Thus, D-shape function ultimately improves overall system damping and concurrently enhances power system reliability.

  20. Comparative Toxicity of Different Crude Oils on the Cardiac Function of Marine Medaka (Oryzias melastigma Embryo

    Directory of Open Access Journals (Sweden)

    Zhendong Zhang

    2014-12-01

    Full Text Available The acute toxic effect of different crude oils (heavy crude oil and bonny light crude oil on embryos of marine medaka Oryzias melastigma was measured and evaluated by exposure to the water-accommodated fraction (WAF in the present study. The cardiac function of medaka embryos was used as target organ of ecotoxicological effect induced by oil exposure. Results showed that the developing marine medaka heart was a sensitive target organ to crude oil exposure the heavy crude oil WAF was more toxic to cardiac function of medaka embryos than bonny light cured oil one. Cardiac function of medaka embryos was clearly affected by exposure to heavy crude oil WAF after 24 hours exposure and showed a dose-dependent slowing of heart rate. Furthermore, swelled and enlarged heart morphology, lowered blood circulation and accumulation of blood cells around the heart area were found. However, the toxic effect of bonny light crude oil on cardiac function of medaka embryos was comparatively low. Statistical results showed that the cardiac function was only affected by highest bonny light crude oil WAF (9.8 mg/L exposure treatment. These findings indicated that cardiac function of marine medaka embryo was a good toxicity model for oil pollution and could be used to compare and evaluate the toxicity of different crude oils. The heart rate was an appropriate endpoint in the acute toxicity test.

  1. Novel disposable transnasal endoscopy for assessment of esophageal motor function.

    Science.gov (United States)

    Lim, Chul-Hyun; Choi, Myung-Gyu; Baeg, Myong-Ki; Moon, Sung Jin; Kim, Jin Su; Cho, Yu Kyung; Park, Jae Myung; Lee, In Seok; Kim, Sang Woo; Choi, Kyu Yong

    2014-01-01

    A novel disposable transnasal endoscopy (DTE) with a portable system has been developed to provide unsedated esophagoscopy by modifying capsule endoscopy. The aim of this study was to assess the feasibility of DTE to evaluate esophageal motor function. Patients with or suspected esophageal motility disorders and healthy volunteers were enrolled. Participants underwent esophageal high-resolution manometry and DTE in random order on different days. Motility was observed with DTE at 1, 8, and 16 cm above the gastroesophageal junction. Twenty healthy volunteers and 20 symptomatic subjects participated (8 achalasia, 5 scleroderma, 3 diffuse esophageal spasm, 1 hypertensive peristalsis, 1 peristaltic dysfunction, and 22 normal esophageal function). The normal findings on DTE were as follows. As the subject swallowed water, swallow-induced relaxation with elevation of the lower esophageal sphincter caused the endoscope to cross the Z-line into the gastric lumen. After the passage of water and air, complete closure of the lower esophageal sphincter occurred, with the return of the endoscope to its previous position. During the resting stage of the esophageal body, an air bubble could be seen in the center of the radially wrinkled and occluded lumen. The endoscopic diagnosis was in agreement with the clinical diagnosis in all but 2. Most of the participants reported acceptable discomfort during DTE and 62.5% of the subjects preferred DTE to manometry. DTE can accurately characterize normal esophageal motor function, allowing the diagnosis of esophageal motility disorders. DTE has potential widespread applications, especially in outpatient clinics.

  2. Endothelial function and dysfunction: clinical significance and assessment

    Directory of Open Access Journals (Sweden)

    Shaghayegh Haghjooyejavanmard

    2008-08-01

    Full Text Available

    • Over the past two decades, investigators have increasingly recognized the importance of the endothelium as a centralregulator of vascular and body homeostasis. The endothelial lining represents an organ of 1.5 kg in an adult, which is distributed throughout the body. The endothelium is versatile and multifunctional. In addition to its role as a selective permeability barrier, it has many synthetic and metabolic properties, including modulation of vascular tone and blood flow, regulation of immune and inflammatory responses, and regulation of coagulation, fibrinolysis and thrombosis. Endothelial dysfunction (ED is a frequently used term, which can be referred to abnormalities in various physiological functions of the endothelium, and it is known as a key variable in the pathogenesis of several diseases and their complications. Finding suitable markers for endothelial damage or ED is certainly of interest. Established and emerging techniques to detect ED are divided into three large families of functional, cellular, and biochemical markers. Instead of performing single assessments, it may be much more valuable to determine various biological aspects of endothelium. It seems that there is likely a spectrum between normality, endothelial activation (by inflammatory cytokines, endothelial dysfunction (e.g., impairment of nitric oxide, resulting in loss of regulation of vascular tone and endothelial damage (e.g., atherosclerosis. In this review we review the importance of endothelium and its activation, biomarkers and dysfunction.
    •  KEYWORDS: Endothelial function, endothelium, Disease.

  3. Assessment of sexual function in patients undergoing vasectomy using the international index of erectile function

    Directory of Open Access Journals (Sweden)

    Eduardo Bertero

    2005-10-01

    Full Text Available INTRODUCTION: The present study aims to prospectively compare the sexual function in males before and after vasectomy surgery using the international index of erectile function (IIEF. MATERIALS AND METHODS: From October to December 2002, sixty-four patients who were candidates for male sterilization in the vasectomy program of the Urology Section at the General Hospital of the University of São Paulo were included. The same investigator applied the IIEF before and 90 days after the surgery. The mean scores obtained on pre and postoperative visits for all domains of sexual function were analyzed and compared with the Wilcoxon test. RESULTS: The mean patient age was 35 years (range from 25 to 48 years and the mean number of children per man was 3. The total mean score of the IIEF was 64.06 before surgery and 65.64 after the procedure, with this difference considered statistically significant (p < 0.001. Sixty-seven per cent of the patients improved their scores, versus 17% and 16% who showed worsening or no change at all in IIEF scores following surgery, respectively. Of the 5 sexual function domains, desire and sexual satisfaction presented statistically significant improvement. CONCLUSION: This study showed that vasectomy caused a positive impact on sexual function, especially on desire and sexual satisfaction, in the majority of men undergoing surgery. There was no case of surgery-related erectile dysfunction.

  4. The family receiving home care: functional health pattern assessment.

    Science.gov (United States)

    Hooper, J I

    1996-01-01

    The winds of change in health care make assessment of the family more important than ever as a tool for health care providers seeking to assist the family move themselves toward high-level wellness. Limited medical care and imposed self-responsibility for health promotion and illness prevention, which are natural consequences of these changes, move the locus of control for health management back to the family. The family's teachings, modeling, and interactions are greater influences than ever on the health of the patient. Gordon's functional health patterns provide a holistic model for assessment of the family because assessment data are classified under 11 headings: health perception and health management, nutritional-metabolic, elimination, activity and exercise, sleep and rest, cognition and perception, self-perception and self-concept, roles and relationships, sexuality and reproduction, coping and stress tolerance, and values and beliefs. Questions posed under each of the health patterns can be varied to reflect the uniqueness of the individual family as well as to inquire about family strengths and weaknesses in all patterns. Data using this model provide a comprehensive base for including the family in designing a plan of care.

  5. A new scintigraphic technique for assessment of right atrial function

    International Nuclear Information System (INIS)

    Marmor, A.; Biello, D.R.; Sampathkumaran, K.S.; Geltman, E.M.; Siegel, B.A.; Roberts, R.

    1981-01-01

    Gated radionuclide imaging with 99 mTc-labeled red blood cells was employed to assess changes in right atrial (RA) volume in 17 subjects. Studies were repeated within two hours in five of 12 normal subjects and at two and ten days after infarction in five patients. Time-activity curves were generated for the RA and right ventricle (RV) from variable regions of interest defined by automatic edge detection. The RA time-activity curve exhibited four phases: filling, early emptying, equilibration, and late emptying. Repeated measurements of RA early emptying rates correlated closely in normals (r . 0.93). Early RA emptying and RV filling rates corresponded closely (r . 0.89). In four patients with infarction, the RA emptying rate was slowed on the first study but had normalized by 10 days. In a patient with inferior infarction and suspected RV infarction, the RA emptying rate was depressed and remained so for 10 days. Thus, relative changes in right atrial volume can be assessed reproducibly by a radionuclide technique, which is relatively independent of geometric assumptions. This technique offers great promise as a method to assess atrial function in health and disease

  6. Using the Reliability Theory for Assessing the Decision Confidence Probability for Comparative Life Cycle Assessments.

    Science.gov (United States)

    Wei, Wei; Larrey-Lassalle, Pyrène; Faure, Thierry; Dumoulin, Nicolas; Roux, Philippe; Mathias, Jean-Denis

    2016-03-01

    Comparative decision making process is widely used to identify which option (system, product, service, etc.) has smaller environmental footprints and for providing recommendations that help stakeholders take future decisions. However, the uncertainty problem complicates the comparison and the decision making. Probability-based decision support in LCA is a way to help stakeholders in their decision-making process. It calculates the decision confidence probability which expresses the probability of a option to have a smaller environmental impact than the one of another option. Here we apply the reliability theory to approximate the decision confidence probability. We compare the traditional Monte Carlo method with a reliability method called FORM method. The Monte Carlo method needs high computational time to calculate the decision confidence probability. The FORM method enables us to approximate the decision confidence probability with fewer simulations than the Monte Carlo method by approximating the response surface. Moreover, the FORM method calculates the associated importance factors that correspond to a sensitivity analysis in relation to the probability. The importance factors allow stakeholders to determine which factors influence their decision. Our results clearly show that the reliability method provides additional useful information to stakeholders as well as it reduces the computational time.

  7. Assessing the genetic overlap between BMI and cognitive function

    Science.gov (United States)

    Marioni, R E; Yang, J; Dykiert, D; Mõttus, R; Campbell, A; Ibrahim-Verbaas, Carla A; Bressler, Jan; Debette, Stephanie; Schuur, Maaike; Smith, Albert V; Davies, Gail; Bennett, David A; Deary, Ian J; Ikram, M Arfan; Launer, Lenore J; Fitzpatrick, Annette L; Seshadri, Sudha; van Duijn, Cornelia M; Mosely Jr, Thomas H; Davies, G; Hayward, C; Porteous, D J; Visscher, P M; Deary, I J

    2016-01-01

    Obesity and low cognitive function are associated with multiple adverse health outcomes across the life course. They have a small phenotypic correlation (r=−0.11; high body mass index (BMI)−low cognitive function), but whether they have a shared genetic aetiology is unknown. We investigated the phenotypic and genetic correlations between the traits using data from 6815 unrelated, genotyped members of Generation Scotland, an ethnically homogeneous cohort from five sites across Scotland. Genetic correlations were estimated using the following: same-sample bivariate genome-wide complex trait analysis (GCTA)–GREML; independent samples bivariate GCTA–GREML using Generation Scotland for cognitive data and four other samples (n=20 806) for BMI; and bivariate LDSC analysis using the largest genome-wide association study (GWAS) summary data on cognitive function (n=48 462) and BMI (n=339 224) to date. The GWAS summary data were also used to create polygenic scores for the two traits, with within- and cross-trait prediction taking place in the independent Generation Scotland cohort. A large genetic correlation of −0.51 (s.e. 0.15) was observed using the same-sample GCTA–GREML approach compared with −0.10 (s.e. 0.08) from the independent-samples GCTA–GREML approach and −0.22 (s.e. 0.03) from the bivariate LDSC analysis. A genetic profile score using cognition-specific genetic variants accounts for 0.08% (P=0.020) of the variance in BMI and a genetic profile score using BMI-specific variants accounts for 0.42% (P=1.9 × 10−7) of the variance in cognitive function. Seven common genetic variants are significantly associated with both traits at Pcognitive function. PMID:26857597

  8. Visual grading of 2D and 3D functional MRI compared with image-based descriptive measures

    Energy Technology Data Exchange (ETDEWEB)

    Ragnehed, Mattias [Linkoeping University, Division of Radiological Sciences, Radiology, IMH, Linkoeping (Sweden); Linkoeping University, Center for Medical Image Science and Visualization, CMIV, Linkoeping (Sweden); Linkoeping University, Department of Medical and Health Sciences, Division of Radiological Sciences/Radiology, Faculty of Health Sciences, Linkoeping (Sweden); Leinhard, Olof Dahlqvist; Pihlsgaard, Johan; Lundberg, Peter [Linkoeping University, Center for Medical Image Science and Visualization, CMIV, Linkoeping (Sweden); Linkoeping University, Division of Radiological Sciences, Radiation Physics, IMH, Linkoeping (Sweden); Wirell, Staffan [Linkoeping University, Division of Radiological Sciences, Radiology, IMH, Linkoeping (Sweden); Linkoeping University Hospital, Department of Radiology, Linkoeping (Sweden); Soekjer, Hannibal; Faegerstam, Patrik [Linkoeping University Hospital, Department of Radiology, Linkoeping (Sweden); Jiang, Bo [Linkoeping University, Center for Medical Image Science and Visualization, CMIV, Linkoeping (Sweden); Smedby, Oerjan; Engstroem, Maria [Linkoeping University, Division of Radiological Sciences, Radiology, IMH, Linkoeping (Sweden); Linkoeping University, Center for Medical Image Science and Visualization, CMIV, Linkoeping (Sweden)

    2010-03-15

    A prerequisite for successful clinical use of functional magnetic resonance imaging (fMRI) is the selection of an appropriate imaging sequence. The aim of this study was to compare 2D and 3D fMRI sequences using different image quality assessment methods. Descriptive image measures, such as activation volume and temporal signal-to-noise ratio (TSNR), were compared with results from visual grading characteristics (VGC) analysis of the fMRI results. Significant differences in activation volume and TSNR were not directly reflected by differences in VGC scores. The results suggest that better performance on descriptive image measures is not always an indicator of improved diagnostic quality of the fMRI results. In addition to descriptive image measures, it is important to include measures of diagnostic quality when comparing different fMRI data acquisition methods. (orig.)

  9. Quantified Uncertainties in Comparative Life Cycle Assessment : What Can Be Concluded?

    NARCIS (Netherlands)

    Mendoza Beltran, Angelica; Prado, Valentina; Font Vivanco, David; Henriksson, Patrik J.G.; Guinée, Jeroen B.; Heijungs, Reinout

    2018-01-01

    Interpretation of comparative Life Cycle Assessment (LCA) results can be challenging in the presence of uncertainty. To aid in interpreting such results under the goal of any comparative LCA, we aim to provide guidance to practitioners by gaining insights into uncertainty-statistics methods (USMs).

  10. A comparative study among the three wheeler automobile drivers on pulmonary function tests in adult males of Gulbarga city

    Directory of Open Access Journals (Sweden)

    Afshan Afroz, Salgar Veeresh B, Sugoor Manjushree, Swati I Amrutha

    2013-01-01

    Full Text Available Development of our country has led to rapid urbanization and there is increasing use of automobiles that is aggravating environmental pollution. Occupational exposure to automobile exhaustand industrial smokes has been shown to affect functioning of different systems of the body. The present study was taken up to assess the Pulmonary Function Tests (PFT in auto rickshaw drivers of Gulbargacity. Methods: Fifty non –smoker male auto drivers in the age group of 20–50 years for more than 5 years of auto driving experience formed the study group. Age and sex matched individuals not exposed to auto rickshaw driving [administrative staff] formed the control group. Pulmonary function parametersFVC, FEV1, FEV1%, PEFR, PIFR, FEF25-75, FEF50 and MVV were assessed using a computerized Spiro meter during their working hours and were statistically analyzed. Results: There was a highly significant decrease in FVC and FEV1 in the study group compared to control group. The decrease in FEV1%, PIFR, FEF25-75 and FEF50 were statistically significant but the decrease in PEFR and MVV were statistically nonsignificant. Conclusion: Our findings point towards the adverse effects of vehicle exhaust on lung functions, mainly on lower airways with restrictive pattern of disease.

  11. Functional approach to the assessment of ocular hazards of low-power lasers

    Energy Technology Data Exchange (ETDEWEB)

    Raybourn, M.S.; Kong, R.L.

    1984-01-01

    An electrophysiological bioassay system has been developed to provide safety-related information about the functional consequences of non-thermal laser irradiation of the vertebrate retina. This in vitro preparation allows precise dosimetry at the retinal surface, provides for an intra-retinal control, comparing lased vs non-lased tissue, and permits quantitative assessment of the biophysical mechanisms of laser-induced retinal dysfunction.

  12. Assessment of Executive Function in Patients With Substance Use Disorder: A Comparison of Inventory- and Performance-Based Assessment.

    Science.gov (United States)

    Hagen, Egon; Erga, Aleksander H; Hagen, Katrin P; Nesvåg, Sverre M; McKay, James R; Lundervold, Astri J; Walderhaug, Espen

    2016-07-01

    Chronic polysubstance abuse (SUD) is associated with neurophysiological and neuroanatomical changes. Neurocognitive impairment tends to affect quality of life, occupational functioning, and the ability to benefit from therapy. Neurocognitive assessment is thus of importance, but costly and not widely available. Therefore, in a busy clinical setting, procedures that include readily available measures targeting core cognitive deficits would be beneficial. This paper investigates the utility of psychometric tests and a questionnaire-based inventory to assess "hot" and "cold" neurocognitive measures of executive functions (EF) in adults with a substance use disorder. Hot decision-making processes are associated with emotional, affective, and visceral responses, while cold executive functions are associated with rational decision-making. Subjects with polysubstance abuse (n=126) and healthy controls (n=32) were compared on hot (Iowa Gambling Task) and cold (Stroop and the Trail Making Test) measures of EF, in addition to a questionnaire assessing everyday EF related problems (BRIEF-A; Behavior Rating Inventory of Executive Function - Adult, self-report version). Information about the substance abuse and social adjustment were assessed by self-report. Logistic regression analyses were applied to assess independent correlates of SUD status and social adjustment. A multiple linear regression was performed to predict the number of previous treatment attempts. The psychometric test of hot EF (the Iowa Gambling Task) did not differentiate the patients with polysubstance abuse from controls, and was not associated with social adjustment. The psychometric tests of cold EF distinguished somewhat between the groups and were associated with one indicator of social adjustment. The BRIEF-A differentiated between groups on all the clinical scales and was associated with three out of five social adjustment indicators ("criminal lifestyle," "conflict with caregiver," and "stable

  13. Pain and functional outcome after vertebroplasty and kyphoplasty. A comparative study

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Santiago, Fernando, E-mail: ferusan@ono.co [Department of Radiology, Hospital of Traumatology (Ciudad Sanitaria Virgen de las Nieves), Carretera de Jaen SN, 18014 Granada (Spain); Perez Abela, Antonio [Department of Traumatology, Hospital of Traumatology (Ciudad Sanitaria Virgen de las Nieves), Carretera de Jaen SN, 18014 Granada (Spain); Guzman Alvarez, Luis [Department of Radiology, Hospital of Traumatology (Ciudad Sanitaria Virgen de las Nieves), Carretera de Jaen SN, 18014 Granada Spain (Spain); Alvarez Osuna, Rosa Maria [Department of Traumatology, Hospital of Traumatology (Ciudad Sanitaria Virgen de las Nieves), Carretera de Jaen SN, 18014 Granada (Spain); Mar Castellano Garcia, Maria del [Department of Radiology, Hospital of Traumatology (Ciudad Sanitaria Virgen de las Nieves), Carretera de Jaen SN, 18014 Granada (Spain)

    2010-08-15

    Purpose: The aim of this study was to compare the effectiveness of percutaneous vertebroplasty and kyphoplasty to treat pain from non-neoplastic vertebral fractures and improve functional outcomes. Materials and methods: We compared 30 patients treated by vertebroplasty for non-neoplastic vertebral fractures with 30 patients treated by kyphoplasty for the same condition. Pain was measured with a visual analogue scale (VAS) and functional outcome with the Oswestry disability index (ODI). Baseline data were compared with measurements on the day after the procedure (for pain alone) and at 1 month, 6 months, and 1 year. Results: The VAS pain score was reduced by 4-5 points on the day after either type of treatment, a statistically significant improvement. The global ODI was significantly improved (by 13-18 points) at 1 month after either procedure. These improvements persisted at 6 months and 1 year. No significant differences in functional outcome were observed between the techniques. Conclusion: Vertebroplasty and kyphoplasty obtain similar improvements in pain and functional outcomes in these patients. The choice of technique must therefore depend on other factors. An initial improvement with either technique is a good predictor of long-term improvement.

  14. Pain and functional outcome after vertebroplasty and kyphoplasty. A comparative study

    International Nuclear Information System (INIS)

    Ruiz Santiago, Fernando; Perez Abela, Antonio; Guzman Alvarez, Luis; Alvarez Osuna, Rosa Maria; Mar Castellano Garcia, Maria del

    2010-01-01

    Purpose: The aim of this study was to compare the effectiveness of percutaneous vertebroplasty and kyphoplasty to treat pain from non-neoplastic vertebral fractures and improve functional outcomes. Materials and methods: We compared 30 patients treated by vertebroplasty for non-neoplastic vertebral fractures with 30 patients treated by kyphoplasty for the same condition. Pain was measured with a visual analogue scale (VAS) and functional outcome with the Oswestry disability index (ODI). Baseline data were compared with measurements on the day after the procedure (for pain alone) and at 1 month, 6 months, and 1 year. Results: The VAS pain score was reduced by 4-5 points on the day after either type of treatment, a statistically significant improvement. The global ODI was significantly improved (by 13-18 points) at 1 month after either procedure. These improvements persisted at 6 months and 1 year. No significant differences in functional outcome were observed between the techniques. Conclusion: Vertebroplasty and kyphoplasty obtain similar improvements in pain and functional outcomes in these patients. The choice of technique must therefore depend on other factors. An initial improvement with either technique is a good predictor of long-term improvement.

  15. Comparing the Costs and Acceptability of Three Fidelity Assessment Methods for Assertive Community Treatment.

    Science.gov (United States)

    Rollins, Angela L; Kukla, Marina; Salyers, Michelle P; McGrew, John H; Flanagan, Mindy E; Leslie, Doug L; Hunt, Marcia G; McGuire, Alan B

    2017-09-01

    Successful implementation of evidence-based practices requires valid, yet practical fidelity monitoring. This study compared the costs and acceptability of three fidelity assessment methods: on-site, phone, and expert-scored self-report. Thirty-two randomly selected VA mental health intensive case management teams completed all fidelity assessments using a standardized scale and provided feedback on each. Personnel and travel costs across the three methods were compared for statistical differences. Both phone and expert-scored self-report methods demonstrated significantly lower costs than on-site assessments, even when excluding travel costs. However, participants preferred on-site assessments. Remote fidelity assessments hold promise in monitoring large scale program fidelity with limited resources.

  16. Safeguard assessment for life extension in nuclear power plants (NPPs) using a production function

    International Nuclear Information System (INIS)

    Woo, Tae-Ho; Lee, Un-Chul

    2011-01-01

    Research highlights: → The numerical value is constructed for the secure operation. → As the power increases, the NSEF increases. → Specific month could be indicated by the relative value of NSEF. → It is suggested for the better power in NPPs. → There is another possibility for the secure operation factors. - Abstract: Life extension is investigated as a safeguard assessment for the stability on the operation of the nuclear power plants (NPPs). The Cobb-Douglas function, one of the production functions, is modified for the nuclear safeguard in NPPs, which was developed for the life quality of the social and natural objects. Nuclear Safeguard Estimator Function (NSEF) is developed for the application in NPPs. The cases of NPPs are compared with each other in the aspect of the secure performance. The results are obtained by the standard productivity comparisons with the designed power operations. The range of secure life extension is between 1.008 and 5.353 in 2000 MW e and the range is between 0.302 and 0.994 in 600 MW e . So, the successfulness of the power operation increases about 5 times higher than that of the interested power in this study, which means that the safeguard assessment has been performed in the life extension of the NPPs. The technology assessment (TA) is suggested for the safe operation which is an advanced method comparing conventional probabilistic safety assessment (PSA).

  17. Measuring everyday functional competence using the Rasch assessment of everyday activity limitations (REAL) item bank.

    Science.gov (United States)

    Oude Voshaar, Martijn A H; Ten Klooster, Peter M; Vonkeman, Harald E; van de Laar, Mart A F J

    2017-11-01

    Traditional patient-reported physical function instruments often poorly differentiate patients with mild-to-moderate disability. We describe the development and psychometric evaluation of a generic item bank for measuring everyday activity limitations in outpatient populations. Seventy-two items generated from patient interviews and mapped to the International Classification of Functioning, Disability and Health (ICF) domestic life chapter were administered to 1128 adults representative of the Dutch population. The partial credit model was fitted to the item responses and evaluated with respect to its assumptions, model fit, and differential item functioning (DIF). Measurement performance of a computerized adaptive testing (CAT) algorithm was compared with the SF-36 physical functioning scale (PF-10). A final bank of 41 items was developed. All items demonstrated acceptable fit to the partial credit model and measurement invariance across age, sex, and educational level. Five- and ten-item CAT simulations were shown to have high measurement precision, which exceeded that of SF-36 physical functioning scale across the physical function continuum. Floor effects were absent for a 10-item empirical CAT simulation, and ceiling effects were low (13.5%) compared with SF-36 physical functioning (38.1%). CAT also discriminated better than SF-36 physical functioning between age groups, number of chronic conditions, and respondents with or without rheumatic conditions. The Rasch assessment of everyday activity limitations (REAL) item bank will hopefully prove a useful instrument for assessing everyday activity limitations. T-scores obtained using derived measures can be used to benchmark physical function outcomes against the general Dutch adult population.

  18. Functional assessment of the hepatic arterial blood flow by pharmacoradiography

    Energy Technology Data Exchange (ETDEWEB)

    Stellamor, K; Hruby, W; Peschl, L

    1981-12-01

    By means of celiacography it was possible to demonstrate that parenteral medication with parathormone creates a selective dilatation of the liver vessels in man, provided that they are dilatable. This hemodynamic hormone effect could not be traced in the other mesenteric vessels. The increase of portal hypertension resulting from cirrhosis leads to a loss of the dilating ability of liver vessels. This regressive reaction is well demonstrated on the parathormone-celiacogram. Thus a functional assessment of the hepatic blood flow is possible. The extent of the dilatability of the liver artery seems to be of great importance for the prognosis and indication of the porto-systemic shunt-operation. Moreover we could show that an increase in the liver perfusion demonstrates pathologic liver processes in a better way.

  19. Nanotechnology in food science: Functionality, applicability, and safety assessment

    Directory of Open Access Journals (Sweden)

    Xiaojia He

    2016-10-01

    Full Text Available Rapid development of nanotechnology is expected to transform many areas of food science and food industry with increasing investment and market share. In this article, current applications of nanotechnology in food systems are briefly reviewed. Functionality and applicability of food-related nanotechnology are highlighted in order to provide a comprehensive view on the development and safety assessment of nanotechnology in the food industry. While food nanotechnology offers great potential benefits, there are emerging concerns arising from its novel physicochemical properties. Therefore, the safety concerns and regulatory policies on its manufacturing, processing, packaging, and consumption are briefly addressed. At the end of this article, the perspectives of nanotechnology in active and intelligent packaging applications are highlighted.

  20. Function assessment of coastal ecosystem based on phytoplankton community structure

    DEFF Research Database (Denmark)

    Haraguchi, Lumi

    2018-01-01

    on phytoplankton community structure; and 3) investigating the role of planktonic communities on the cycling of dissolved organic matter. Those objectives were addressed focusing the temperate mesohaline estuary of Roskilde Fjord (Denmark). Paper I, explores the use of Pulse-shape recording flow cytometry (PFCM...... as an energy reservoir, buffering changes in the nutrient supply. Finally, the results embedded in this thesis demonstrate the importance of integrating different time scales to understand functioning of phytoplankton communities. Phytoplankton dynamics should not be regarded just in light of inorganic......This Ph.D. project aimed to improve the knowledge on phytoplankton community structure and its influence in the carbon transfer and nutrient cycling in coastal waters, by: 1) assessing the importance of phytoplankton

  1. Assessing Differential Item Functioning on the Test of Relational Reasoning

    Directory of Open Access Journals (Sweden)

    Denis Dumas

    2018-03-01

    Full Text Available The test of relational reasoning (TORR is designed to assess the ability to identify complex patterns within visuospatial stimuli. The TORR is designed for use in school and university settings, and therefore, its measurement invariance across diverse groups is critical. In this investigation, a large sample, representative of a major university on key demographic variables, was collected, and the resulting data were analyzed using a multi-group, multidimensional item-response theory model-comparison procedure. No significant differential item functioning was found on any of the TORR items across any of the demographic groups of interest. This finding is interpreted as evidence of the cultural fairness of the TORR, and potential test-development choices that may have contributed to that cultural fairness are discussed.

  2. Foot length is a functional parameter for assessment of height.

    Science.gov (United States)

    Krishan, Kewal; Kanchan, Tanuj

    2013-03-01

    Stature estimation is considered as an important parameter in the examination of unknown human remains and during the analysis of evidence in crime scene investigations. During mass disasters isolated foot can be found enclosed in the shoes while footprints may be recovered at the crime scenes. Foot length and footprint length can provide valuable estimates of stature. The present communication makes a few pertinent observations on a recently published article in 'The Foot' entitled 'Foot length-a functional parameter for assessment of height, The Foot 2012, 22(1):31-34' and presents an insight into the literature available on the subject which is likely to be of value to future researchers in the field of Forensic Podiatry. The foot length and the footprint length of individuals differ from each other and hence, the research observations made in a study on foot prints cannot be applied to foot dimensions. Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. Nanotechnology in food science: Functionality, applicability, and safety assessment.

    Science.gov (United States)

    He, Xiaojia; Hwang, Huey-Min

    2016-10-01

    Rapid development of nanotechnology is expected to transform many areas of food science and food industry with increasing investment and market share. In this article, current applications of nanotechnology in food systems are briefly reviewed. Functionality and applicability of food-related nanotechnology are highlighted in order to provide a comprehensive view on the development and safety assessment of nanotechnology in the food industry. While food nanotechnology offers great potential benefits, there are emerging concerns arising from its novel physicochemical properties. Therefore, the safety concerns and regulatory policies on its manufacturing, processing, packaging, and consumption are briefly addressed. At the end of this article, the perspectives of nanotechnology in active and intelligent packaging applications are highlighted. Copyright © 2016. Published by Elsevier B.V.

  4. Remote online ergonomic assessment in the office environment as compared to face-to-face ergonomic assessment.

    Science.gov (United States)

    Eyal, Levy; Ribak, Joseph; Badihi, Yehuda

    2012-01-01

    remote online ergonomic assessment in the office environment as compared to face-to-face ergonomic assessment and examination of the applicability of remote online ergonomic assessment to office workers. 40 employees from a large Israeli hi-tech company were ergonomically assessed per the University of California computer usage checklist, according to the two assessment types (face-to-face and remote). An additional Ergonomist "assessor 2" examined the credibility of the process. Research hypothesis 1 was verified: 21 out of 22 questions (95.45%) from the checklist indicated compatibility between "assessor 1" to the "Gold Standard" at an 80% level. Research hypothesis 2: examining the credibility between the assessors with regard to remote assessment. This hypothesis was partially verified, the correlation between the assessors was measured at 0.54. Research hypothesis 3: examining the extent of deviation of natural posture between distal body parts assessment (distant from the center of the body) and proximal body parts (close to the center of the body). This hypothesis was clearly verified. It has been proven that there is statistical significance between the results. The current research has proved that there is an additional method to assess musculoskeletal disorders risk factors remotely online at office environment.

  5. The effect of language on functional capacity assessment in middle-aged and older US Latinos with schizophrenia.

    Science.gov (United States)

    Bengoetxea, Eneritz; Burton, Cynthia Z; Mausbach, Brent T; Patterson, Thomas L; Twamley, Elizabeth W

    2014-08-15

    The U.S. Latino population is steadily increasing, prompting a need for cross-cultural outcome measures in schizophrenia research. This study examined the contribution of language to functional assessment in middle-aged Latino patients with schizophrenia by comparing 29 monolingual Spanish-speakers, 29 Latino English-speakers, and 29 non-Latino English-speakers who were matched on relevant demographic variables and who completed cognitive and functional assessments in their native language. There were no statistically significant differences between groups on the four everyday functioning variables (UCSD Performance-Based Skills Assessment [UPSA], Social Skills Performance Assessment [SSPA], Medication Management Ability Assessment [MMAA], and the Global Assessment of Functioning [GAF]). The results support the cross-linguistic and cross-cultural acceptability of these functional assessment instruments. It appears that demographic variables other than language (e.g., age, education) better explain differences in functional assessment among ethnically diverse subpopulations. Considering the influence of these other factors in addition to language on functional assessments will help ensure that measures can be appropriately interpreted among the diverse residents of the United States. Published by Elsevier Ireland Ltd.

  6. The effect of language on functional capacity assessment in middle-aged and older US Latinos with schizophrenia

    Science.gov (United States)

    Bengoetxea, Eneritz; Burton, Cynthia Z.; Mausbach, Brent T.; Patterson, Thomas L.; Twamley, Elizabeth W.

    2014-01-01

    The U.S. Latino population is steadily increasing, prompting a need for cross-cultural outcome measures in schizophrenia research. This study examined the contribution of language to functional assessment in middle-aged Latino patients with schizophrenia by comparing 29 monolingual Spanish-speakers, 29 Latino English-speakers, and 29 non-Latino English-speakers who were matched on relevant demographic variables and who completed cognitive and functional assessments in their native language. There were no statistically significant differences between groups on the four everyday functioning variables (UCSD Performance-Based Skills Assessment [UPSA], Social Skills Performance Assessment [SSPA], Medication Management Ability Assessment [MMAA], and the Global Assessment of Functioning [GAF]). The results support the cross-linguistic and cross-cultural acceptability of these functional assessment instruments. It appears that demographic variables other than language (e.g., age, education) better explain differences in functional assessment among ethnically diverse subpopulations. Considering the influence of these other factors in addition to language on functional assessments will help ensure that measures can be appropriately interpreted among the diverse residents of the United States. PMID:24751379

  7. Comparative analyses identified species-specific functional roles in oral microbial genomes

    Science.gov (United States)

    Chen, Tsute; Gajare, Prasad; Olsen, Ingar; Dewhirst, Floyd E.

    2017-01-01

    ABSTRACT The advent of next generation sequencing is producing more genomic sequences for various strains of many human oral microbial species and allows for insightful functional comparisons at both intra- and inter-species levels. This study performed in-silico functional comparisons for currently available genomic sequences of major species associated with periodontitis including Aggregatibacter actinomycetemcomitans (AA), Porphyromonas gingivalis (PG), Treponema denticola (TD), and Tannerella forsythia (TF), as well as several cariogenic and commensal streptococcal species. Complete or draft sequences were annotated with the RAST to infer structured functional subsystems for each genome. The subsystems profiles were clustered to groups of functions with similar patterns. Functional enrichment and depletion were evaluated based on hypergeometric distribution to identify subsystems that are unique or missing between two groups of genomes. Unique or missing metabolic pathways and biological functions were identified in different species. For example, components involved in flagellar motility were found only in the motile species TD, as expected, with few exceptions scattered in several streptococcal species, likely associated with chemotaxis. Transposable elements were only found in the two Bacteroidales species PG and TF, and half of the AA genomes. Genes involved in CRISPR were prevalent in most oral species. Furthermore, prophage related subsystems were also commonly found in most species except for PG and Streptococcus mutans, in which very few genomes contain prophage components. Comparisons between pathogenic (P) and nonpathogenic (NP) genomes also identified genes potentially important for virulence. Two such comparisons were performed between AA (P) and several A. aphrophilus (NP) strains, and between S. mutans + S. sobrinus (P) and other oral streptococcal species (NP). This comparative genomics approach can be readily used to identify functions unique to

  8. Comparing Transformation Possibilities of Topological Functioning Model and BPMN in the Context of Model Driven Architecture

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    Solomencevs Artūrs

    2016-05-01

    Full Text Available The approach called “Topological Functioning Model for Software Engineering” (TFM4SE applies the Topological Functioning Model (TFM for modelling the business system in the context of Model Driven Architecture. TFM is a mathematically formal computation independent model (CIM. TFM4SE is compared to an approach that uses BPMN as a CIM. The comparison focuses on CIM modelling and on transformation to UML Sequence diagram on the platform independent (PIM level. The results show the advantages and drawbacks the formalism of TFM brings into the development.

  9. Functional assessment of feet of patients with type II diabetes

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    Vinicius Saura Cardoso

    2014-09-01

    Full Text Available Objective: To evaluate the incidence of functional changes and risk of developing ulcers in type II diabetic patients seen in Primary Healthcare Units (Unidades Básicas de Saúde- UBS. Methods: A cross-sectional, quantitative and descriptive study comprising 80patients with type II diabetes mellitus (DM aged between 41 to 85 years and attended inthe UBS in the city of Parnaíba-PI. Volunteers responded to the identification form and theMichigan Neuropathy Screening Instrument (MNSI, followed by an evaluation of the lowerlimbs, as follows: achilles and patellar reflex, palpation of arterial pulses (dorsalis pedis and posterior tibial, tactile sensitivity (Monofilament 10g and vibration sensitivity (128Hz tuning fork; identification of the presence of changes such as ingrown toenails, calluses,claw toes and hair loss. Finally, using the information acquired from the assessment, subjects were classified according to the risk of developing wounds. Results: The sample consisted of 76 diabetic patients, with average age of 63.8 ± 10.4 years, 63 (82.8% were female, mean diagnostic time 8.8 ± 7.2 years, average body mass index (BMI 28.2 ± 5.4 kg/m2, with 15.7% of the sample being smokers. The myotatic reflexes and arterial pulses were reduced. Tactile sensitivity was identified in 81.5% and 13.1% did not feel the vibration of the tuning fork. The most dominant changes identified were calluses, 76.3% (n = 58. Risk level 2 of developing ulcers stood out, 52.6% (n = 40. Conclusion: Functional changes were detected in the sample and a classification of risk 2 for developing wounds was found in more than 50% of the assessed patients. doi:http://dx.doi.org/10.5020/18061230.2013.p563

  10. Alternative parameters for echocardiographic assessment of fetal diastolic function

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    Zielinsky P.

    2004-01-01

    Full Text Available Alternative methods to assess ventricular diastolic function in the fetus are proposed. Fetal myocardial hypertrophy in maternal diabetes was used as a model of decreased left ventricular compliance (LVC, and fetal respiratory movements as a model of increased LVC. Comparison of three groups of fetuses showed that, in 10 fetuses of diabetic mothers (FDM with septal hypertrophy (SH, the mean excursion index of the septum primum (EISP (ratio between the linear excursion of the flap valve and the left atrial diameter was 0.36 ± 0.09, in 8 FDM without SH it was 0.51 ± 0.09 (P = 0.001, and in the 8 normal control fetuses (NCF it was 0.49 ± 0.12 (P = 0.003. In another study, 28 fetuses in apnea had a mean EISP of 0.39 ± 0.05 which increased to 0.57 ± 0.07 during respiration (P < 0.001. These two studies showed that the mobility of the septum primum was reduced when LVC was decreased and was increased when LVC was enhanced. Mean pulmonary vein pulsatility was higher in 14 FDM (1.83 ± 1.21 than in 26 NCF (1.02 ± 0.31; P = 0.02. In the same fetuses, mean left atrial shortening was decreased (0.40 ± 0.11 in relation to NCF (0.51 ± 0.09; P = 0.011. These results suggest that FDM may have a higher preload than normal controls, probably as a result of increased myocardial mass and LV hypertrophy. Prenatal assessment of LV diastolic function by fetal echocardiography should include analysis of septum primum mobility, pulmonary vein pulsatility, and left atrial shortening.

  11. Construction and pilot assessment of the Lower Limb Function Assessment Scale.

    Science.gov (United States)

    Allart, Etienne; Paquereau, Julie; Rogeau, Caroline; Daveluy, Walter; Kozlowski, Odile; Rousseaux, Marc

    2014-01-01

    Stroke often leads to upright standing and walking impairments. Clinical assessments do not sufficiently address ecological aspects and the patient's subjective evaluation of function. To perform a pilot assessment of the psychometric properties of the Lower Limb-Function Assessment Scale (LL-FAS). The LL-FAS includes 30 items assessing the patient's perception (in a questionnaire) and the examiner's perception (in a practical test) of upright standing and walking impairments and their impact on activities of daily living. We analyzed the LL-FAS's reliability, construct validity, internal consistency, predictive validity and feasibility. Thirty-five stroke patients were included. The scale's mean ± SD completion time was 25 ± 6 min. Intra-observer reliability was good to excellent (intraclass correlation coefficients (ICC >0.82). Interobserver reliability was moderate (0.67 0.9) and predictive validity were excellent. The LL-FAS showed fair psychometric properties in this pilot study and may be of value for evaluating post-stroke lower limb impairment.

  12. Vocal Function Exercises for Muscle Tension Dysphonia: Auditory-Perceptual Evaluation and Self-Assessment Rating.

    Science.gov (United States)

    Jafari, Narges; Salehi, Abolfazl; Izadi, Farzad; Talebian Moghadam, Saeed; Ebadi, Abbas; Dabirmoghadam, Payman; Faham, Maryam; Shahbazi, Mehdi

    2017-07-01

    Muscle tension dysphonia (MTD) is a functional dysphonia, which appears with an excessive tension in the intrinsic and extrinsic laryngeal musculatures. MTD can affect voice quality and quality of life. The purpose of the present study was to assess the effectiveness of vocal function exercises (VFEs) on perceptual and self-assessment ratings in a group of 15 subjects with MTD. The study comprised 15 subjects with MTD (8 men and 7 women, mean age 39.8 years, standard deviation 10.6, age range 24-62 years). All participants were native Persian speakers who underwent a 6-week course of VFEs. The Voice Handicap Index (VHI) (the self-assessment scale) and Grade, Roughness, Breathiness, Asthenia, Strain (GRBAS) scale (perceptual rating of voice quality) were used to compare pre- and post-VFEs. GRBAS data of patients before and after VFEs were compared using Wilcoxon signed-rank test, and VHI data of patients pre- and post-VFEs were compared using Student paired t test. These perceptual parameters showed a statistically significant improvement in subjects with MTD after voice therapy (significant at P self-assessment ratings measurements (with the VHI). As a result, the data provide evidence regarding the efficacy of VFEs in the treatment of patients with MTD. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  13. Critical Zone Experimental Design to Assess Soil Processes and Function

    Science.gov (United States)

    Banwart, Steve

    2010-05-01

    Through unsustainable land use practices, mining, deforestation, urbanisation and degradation by industrial pollution, soil losses are now hypothesized to be much faster (100 times or more) than soil formation - with the consequence that soil has become a finite resource. The crucial challenge for the international research community is to understand the rates of processes that dictate soil mass stocks and their function within Earth's Critical Zone (CZ). The CZ is the environment where soils are formed, degrade and provide their essential ecosystem services. Key among these ecosystem services are food and fibre production, filtering, buffering and transformation of water, nutrients and contaminants, storage of carbon and maintaining biological habitat and genetic diversity. We have initiated a new research project to address the priority research areas identified in the European Union Soil Thematic Strategy and to contribute to the development of a global network of Critical Zone Observatories (CZO) committed to soil research. Our hypothesis is that the combined physical-chemical-biological structure of soil can be assessed from first-principles and the resulting soil functions can be quantified in process models that couple the formation and loss of soil stocks with descriptions of biodiversity and nutrient dynamics. The objectives of this research are to 1. Describe from 1st principles how soil structure influences processes and functions of soils, 2. Establish 4 European Critical Zone Observatories to link with established CZOs, 3. Develop a CZ Integrated Model of soil processes and function, 4. Create a GIS-based modelling framework to assess soil threats and mitigation at EU scale, 5. Quantify impacts of changing land use, climate and biodiversity on soil function and its value and 6. Form with international partners a global network of CZOs for soil research and deliver a programme of public outreach and research transfer on soil sustainability. The

  14. Assessing Executive Function components in 9 years old children

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    Sandra Reyes

    2014-05-01

    Full Text Available Executive Function (EF is a multidimensional construct. It includes a set of abilities that allows to execute actions with a purpose, aimed to a goal, in an efficient way. The objective of this work is to explore some of the cognitive abilities that constitute a common factor for EF in 9 years-old children. The chosen instruments: Batería de Evaluación Neuropsicológica de la Función Ejecutiva en niños (ENFEN (Battery of Neuropsychological Assessment for Executive Function in Children, along with the Backward Digits Subtestfrom the WISC-III, were administered to 101 children from private schools of Buenos Aires State, Argentina. The ENFEN consists on EF tasks, including Phonological and Semantic Fluency, Trail Making Test versions for children (gray and colored sets, Interference Task, and Planning disc movements according to a model. An initial confirmatory factor analysis didn’t show significant fit indexes, being the Inhibitory control the variable with the lower and non significant factorial weight. A second model excluding the Inhibitory control measure was conducted, and it showed excellent fit indexes. Therefore, it can be concluded that at this age, some of the cognitive abilities included on the EF are: Phonological and Semantic Fluency, Sustained and Selective attention, Planning and Working memory; which is not the case for Inhibitory Control (measured by the Interference Task in the ENFEN.

  15. Automated respiratory sinus arrhythmia measurement: Demonstration using executive function assessment.

    Science.gov (United States)

    Hegarty-Craver, Meghan; Gilchrist, Kristin H; Propper, Cathi B; Lewis, Gregory F; DeFilipp, Samuel J; Coffman, Jennifer L; Willoughby, Michael T

    2017-08-08

    Respiratory sinus arrhythmia (RSA) is a quantitative metric that reflects autonomic nervous system regulation and provides a physiological marker of attentional engagement that supports cognitive and affective regulatory processes. RSA can be added to executive function (EF) assessments with minimal participant burden because of the commercial availability of lightweight, wearable electrocardiogram (ECG) sensors. However, the inclusion of RSA data in large data collection efforts has been hindered by the time-intensive processing of RSA. In this study we evaluated the performance of an automated RSA-scoring method in the context of an EF study in preschool-aged children. The absolute differences in RSA across both scoring methods were small (mean RSA differences = -0.02-0.10), with little to no evidence of bias for the automated relative to the hand-scoring approach. Moreover, the relative rank-ordering of RSA across both scoring methods was strong (rs = .96-.99). Reliable changes in RSA from baseline to the EF task were highly similar across both scoring methods (96%-100% absolute agreement; Kappa = .83-1.0). On the basis of these findings, the automated RSA algorithm appears to be a suitable substitute for hand-scoring in the context of EF assessment.

  16. Comparing the Functioning of Youth and Adult Partnerships for Health Promotion.

    Science.gov (United States)

    Brown, Louis D; Redelfs, Alisha H; Taylor, Thomas J; Messer, Reanna L

    2015-09-01

    Youth partnerships are a promising but understudied strategy for prevention and health promotion. Specifically, little is known about how the functioning of youth partnerships differs from that of adult partnerships. Accordingly, this study compared the functioning of youth partnerships with that of adult partnerships. Several aspects of partnership functioning, including leadership, task focus, cohesion, participation costs and benefits, and community support, were examined. Standardized partnership functioning surveys were administered to participants in three smoke-free youth coalitions (n = 44; 45 % female; 43 % non-Hispanic white; mean age = 13) and in 53 Communities That Care adult coalitions (n = 673; 69 % female; 88 % non-Hispanic white; mean age = 49). Multilevel regression analyses showed that most aspects of partnership functioning did not differ significantly between youth and adult partnerships. These findings are encouraging given the success of the adult partnerships in reducing community-level rates of substance use and delinquency. Although youth partnership functioning appears to be strong enough to support effective prevention strategies, youth partnerships faced substantially more participation difficulties than adult partnerships. Strategies that youth partnerships can use to manage these challenges, such as creative scheduling and increasing opportunities for youth to help others directly, are discussed.

  17. Seven-Year Follow-Up Assessment of Cardiac Function in NSABP B-31, a Randomized Trial Comparing Doxorubicin and Cyclophosphamide Followed by Paclitaxel (ACP) With ACP Plus Trastuzumab As Adjuvant Therapy for Patients With Node-Positive, Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

    Science.gov (United States)

    Romond, Edward H.; Jeong, Jong-Hyeon; Rastogi, Priya; Swain, Sandra M.; Geyer, Charles E.; Ewer, Michael S.; Rathi, Vikas; Fehrenbacher, Louis; Brufsky, Adam; Azar, Catherine A.; Flynn, Patrick J.; Zapas, John L.; Polikoff, Jonathan; Gross, Howard M.; Biggs, David D.; Atkins, James N.; Tan-Chiu, Elizabeth; Zheng, Ping; Yothers, Greg; Mamounas, Eleftherios P.; Wolmark, Norman

    2012-01-01

    Purpose Cardiac dysfunction (CD) is a recognized risk associated with the addition of trastuzumab to adjuvant chemotherapy for human epidermal growth factor receptor 2–positive breast cancer, especially when the treatment regimen includes anthracyclines. Given the demonstrated efficacy of trastuzumab, ongoing assessment of cardiac safety and identification of risk factors for CD are important for optimal patient care. Patients and Methods In National Surgical Adjuvant Breast and Bowel Project B-31, a phase III adjuvant trial, 1,830 patients who met eligibility criteria for initiation of trastuzumab were evaluated for CD. Recovery from CD was also assessed. A statistical model was developed to estimate the risk of severe congestive heart failure (CHF). Baseline patient characteristics associated with anthracycline-related decline in cardiac function were also identified. Results At 7-year follow-up, 37 (4.0%) of 944 patients who received trastuzumab experienced a cardiac event (CE) versus 10 (1.3%) of 743 patients in the control arm. One cardiac-related death has occurred in each arm of the protocol. A Cardiac Risk Score, calculated using patient age and baseline left ventricular ejection fraction (LVEF) by multiple-gated acquisition scan, statistically correlates with the risk of a CE. After stopping trastuzumab, the majority of patients who experienced CD recovered LVEF in the normal range, although some decline from baseline often persists. Only two CEs occurred more than 2 years after initiation of trastuzumab. Conclusion The late development of CHF after the addition of trastuzumab to paclitaxel after doxorubicin/ cyclophosphamide chemotherapy is uncommon. The risk versus benefit of trastuzumab as given in this regimen remains strongly in favor of trastuzumab. PMID:22987084

  18. Comparing individual differences in inconsistency and plasticity as predictors of cognitive function in older adults.

    Science.gov (United States)

    Grand, Jacob H G; Stawski, Robert S; MacDonald, Stuart W S

    2016-01-01

    Recent theorizing differentiates key constraints on cognition, including one's current range of processing efficiency (i.e., flexibility or inconsistency) as well as the capacity to expand flexibility over time (i.e., plasticity). The present study uses intensive assessment of response time data to examine the interplay between markers of intraindividual variability (inconsistency) and gains across biweekly retest sessions (plasticity) in relation to age-related cognitive function. Participants included 304 adults (aged 64 to 92 years: M = 74.02, SD = 5.95) from Project MIND, a longitudinal burst design study assessing performance across micro and macro intervals (response latency trials, weekly bursts, annual retests). For two reaction time (RT) measures (choice RT and one-back choice RT), baseline measures of RT inconsistency (intraindividual standard deviation, ISD, across trials at the first testing session) and plasticity (within-person performance gains in average RT across the 5 biweekly burst sessions) were computed and were then employed in linear mixed models as predictors of individual differences in cognitive function and longitudinal (6-year) rates of cognitive change. Independent of chronological age and years of education, higher RT inconsistency was associated uniformly with poorer cognitive function at baseline and with increased cognitive decline for measures of episodic memory and crystallized verbal ability. In contrast, predictive associations for plasticity were more modest for baseline cognitive function and were absent for 6-year cognitive change. These findings underscore the potential utility of response times for articulating inconsistency and plasticity as dynamic predictors of cognitive function in older adults.

  19. Comparative genome analysis of PHB gene family reveals deep evolutionary origins and diverse gene function.

    Science.gov (United States)

    Di, Chao; Xu, Wenying; Su, Zhen; Yuan, Joshua S

    2010-10-07

    PHB (Prohibitin) gene family is involved in a variety of functions important for different biological processes. PHB genes are ubiquitously present in divergent species from prokaryotes to eukaryotes. Human PHB genes have been found to be associated with various diseases. Recent studies by our group and others have shown diverse function of PHB genes in plants for development, senescence, defence, and others. Despite the importance of the PHB gene family, no comprehensive gene family analysis has been carried to evaluate the relatedness of PHB genes across different species. In order to better guide the gene function analysis and understand the evolution of the PHB gene family, we therefore carried out the comparative genome analysis of the PHB genes across different kingdoms. The relatedness, motif distribution, and intron/exon distribution all indicated that PHB genes is a relatively conserved gene family. The PHB genes can be classified into 5 classes and each class have a very deep evolutionary origin. The PHB genes within the class maintained the same motif patterns during the evolution. With Arabidopsis as the model species, we found that PHB gene intron/exon structure and domains are also conserved during the evolution. Despite being a conserved gene family, various gene duplication events led to the expansion of the PHB genes. Both segmental and tandem gene duplication were involved in Arabidopsis PHB gene family expansion. However, segmental duplication is predominant in Arabidopsis. Moreover, most of the duplicated genes experienced neofunctionalization. The results highlighted that PHB genes might be involved in important functions so that the duplicated genes are under the evolutionary pressure to derive new function. PHB gene family is a conserved gene family and accounts for diverse but important biological functions based on the similar molecular mechanisms. The highly diverse biological function indicated that more research needs to be carried out

  20. Comparative Genomics Unravels the Functional Roles of Co-occurring Acidophilic Bacteria in Bioleaching Heaps

    Science.gov (United States)

    Zhang, Xian; Liu, Xueduan; Liang, Yili; Xiao, Yunhua; Ma, Liyuan; Guo, Xue; Miao, Bo; Liu, Hongwei; Peng, Deliang; Huang, Wenkun; Yin, Huaqun

    2017-01-01

    The spatial-temporal distribution of populations in various econiches is thought to be potentially related to individual differences in the utilization of nutrients or other resources, but their functional roles in the microbial communities remain elusive. We compared differentiation in gene repertoire and metabolic profiles, with a focus on the potential functional traits of three commonly recognized members (Acidithiobacillus caldus, Leptospirillum ferriphilum, and Sulfobacillus thermosulfidooxidans) in bioleaching heaps. Comparative genomics revealed that intra-species divergence might be driven by horizontal gene transfer. These co-occurring bacteria shared a few homologous genes, which significantly suggested the genomic differences between these organisms. Notably, relatively more genes assigned to the Clusters of Orthologous Groups category [G] (carbohydrate transport and metabolism) were identified in Sulfobacillus thermosulfidooxidans compared to the two other species, which probably indicated their mixotrophic capabilities that assimilate both organic and inorganic forms of carbon. Further inspection revealed distinctive metabolic capabilities involving carbon assimilation, nitrogen uptake, and iron-sulfur cycling, providing robust evidence for functional differences with respect to nutrient utilization. Therefore, we proposed that the mutual compensation of functionalities among these co-occurring organisms might provide a selective advantage for efficiently utilizing the limited resources in their habitats. Furthermore, it might be favorable to chemoautotrophs' lifestyles to form mutualistic interactions with these heterotrophic and/or mixotrophic acidophiles, whereby the latter could degrade organic compounds to effectively detoxify the environments. Collectively, the findings shed light on the genetic traits and potential metabolic activities of these organisms, and enable us to make some inferences about genomic and functional differences that might

  1. Comparative Genomics Unravels the Functional Roles of Co-occurring Acidophilic Bacteria in Bioleaching Heaps

    Directory of Open Access Journals (Sweden)

    Xian Zhang

    2017-05-01

    Full Text Available The spatial-temporal distribution of populations in various econiches is thought to be potentially related to individual differences in the utilization of nutrients or other resources, but their functional roles in the microbial communities remain elusive. We compared differentiation in gene repertoire and metabolic profiles, with a focus on the potential functional traits of three commonly recognized members (Acidithiobacillus caldus, Leptospirillum ferriphilum, and Sulfobacillus thermosulfidooxidans in bioleaching heaps. Comparative genomics revealed that intra-species divergence might be driven by horizontal gene transfer. These co-occurring bacteria shared a few homologous genes, which significantly suggested the genomic differences between these organisms. Notably, relatively more genes assigned to the Clusters of Orthologous Groups category [G] (carbohydrate transport and metabolism were identified in Sulfobacillus thermosulfidooxidans compared to the two other species, which probably indicated their mixotrophic capabilities that assimilate both organic and inorganic forms of carbon. Further inspection revealed distinctive metabolic capabilities involving carbon assimilation, nitrogen uptake, and iron-sulfur cycling, providing robust evidence for functional differences with respect to nutrient utilization. Therefore, we proposed that the mutual compensation of functionalities among these co-occurring organisms might provide a selective advantage for efficiently utilizing the limited resources in their habitats. Furthermore, it might be favorable to chemoautotrophs' lifestyles to form mutualistic interactions with these heterotrophic and/or mixotrophic acidophiles, whereby the latter could degrade organic compounds to effectively detoxify the environments. Collectively, the findings shed light on the genetic traits and potential metabolic activities of these organisms, and enable us to make some inferences about genomic and functional

  2. Comparative impact of AAV and enzyme replacement therapy on respiratory and cardiac function in adult Pompe mice

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    Darin J Falk

    Full Text Available Pompe disease is an autosomal recessive genetic disorder characterized by a deficiency of the enzyme responsible for degradation of lysosomal glycogen (acid α-glucosidase (GAA. Cardiac dysfunction and respiratory muscle weakness are primary features of this disorder. To attenuate the progressive and rapid accumulation of glycogen resulting in cardiorespiratory dysfunction, adult Gaa−/− mice were administered a single systemic injection of rAAV2/9-DES-hGAA (AAV9-DES or bimonthly injections of recombinant human GAA (enzyme replacement therapy (ERT. Assessment of cardiac function and morphology was measured 1 and 3 months after initiation of treatment while whole-body plethysmography and diaphragmatic contractile function was evaluated at 3 months post-treatment in all groups. Gaa−/− animals receiving either AAV9-DES or ERT demonstrated a significant improvement in cardiac function and diaphragmatic contractile function as compared to control animals. AAV9-DES treatment resulted in a significant reduction in cardiac dimension (end diastolic left ventricular mass/gram wet weight; EDMc at 3 months postinjection. Neither AAV nor ERT therapy altered minute ventilation during quiet breathing (eupnea. However, breathing frequency and expiratory time were significantly improved in AAV9-DES animals. These results indicate systemic delivery of either strategy improves cardiac function but AAV9-DES alone improves respiratory parameters at 3 months post-treatment in a murine model of Pompe disease.

  3. Effectiveness of Pelvic Physiotherapy in Children With Functional Constipation Compared With Standard Medical Care.

    Science.gov (United States)

    van Engelenburg-van Lonkhuyzen, Marieke L; Bols, Esther M J; Benninga, Marc A; Verwijs, Wim A; de Bie, Rob A

    2017-01-01

    Functional constipation (FC) is a common childhood problem often related to pelvic floor muscle dysfunction. We compared the effectiveness of pelvic physiotherapy (PPT) vs standard medical care (SMC) in children with FC. We performed a multicenter randomized controlled trial of 53 children (age, 5-16 y) with FC according to the Rome III criteria, at hospitals in The Netherlands from December 2009 to May 2014. Group allocation was concealed using a central computer system. SMC consisted of education, toilet training, and laxatives (n = 26), whereas PPT included SMC plus specific physiotherapeutic interventions (n = 27). Results were obtained from written reports from the subjects' pediatricians and parents. The primary outcome was absence of FC, according to Rome III criteria, after a 6-month follow-up period. Secondary outcomes were global perceived effect (range, 1-9; success was defined as a score ≥ 8), numeric rating scales assessing quality of life (parent and child; scale, 1-10), and the strengths and difficulties questionnaire (SDQ). Treatment was effective for 92.3% of the children receiving PPT and for 63.0% of the children receiving SMC (adjusted odds ratio for success of PPT, 11.7; 95% confidence interval, 1.8-78.3) (P = .011). Significantly more children undergoing PPT stopped using laxatives (adjusted odds ratio, 6.5; 95% confidence interval, 1.6-26.4) (P = .009). Treatment success (based on global perceived effect) was achieved for 88.5% of subjects receiving PPT vs 33.3% of subjects receiving SMC) (P children (P = .028). Results from the SDQ did not differ significantly between groups (P = .78). In a randomized controlled trial of children with FC, PPT was more effective than SMC on all outcomes measured, with the exception of findings from the SDQ. PPT should be considered as a treatment option for FC in children 5-16 years old. Dutch Clinical Trial Registration no: NL30551.068.09. Copyright © 2017 AGA Institute. Published by Elsevier Inc

  4. An attempt to understand kidney's protein handling function by comparing plasma and urine proteomes.

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    Lulu Jia

    Full Text Available BACKGROUND: With the help of proteomics technology, the human plasma and urine proteomes, which closely represent the protein compositions of the input and output of the kidney, respectively, have been profiled in much greater detail by different research teams. Many datasets have been accumulated to form "reference profiles" of the plasma and urine proteomes. Comparing these two proteomes may help us understand the protein handling aspect of kidney function in a way, however, which has been unavailable until the recent advances in proteomics technology. METHODOLOGY/PRINCIPAL FINDINGS: After removing secreted proteins downstream of the kidney, 2611 proteins in plasma and 1522 in urine were identified with high confidence and compared based on available proteomic data to generate three subproteomes, the plasma-only subproteome, the plasma-and-urine subproteome, and the urine-only subproteome, and they correspond to three groups of proteins that are handled in three different ways by the kidney. The available experimental molecular weights of the proteins in the three subproteomes were collected and analyzed. Since the functions of the overrepresented proteins in the plasma-and-urine subproteome are probably the major functions that can be routinely regulated by excretion from the kidney in physiological conditions, Gene Ontology term enrichment in the plasma-and-urine subproteome versus the whole plasma proteome was analyzed. Protease activity, calcium and growth factor binding proteins, and coagulation and immune response-related proteins were found to be enriched. CONCLUSION/SIGNIFICANCE: The comparison method described in this paper provides an illustration of a new approach for studying organ functions with a proteomics methodology. Because of its distinctive input (plasma and output (urine, it is reasonable to predict that the kidney will be the first organ whose functions are further elucidated by proteomic methods in the near future. It

  5. Neuropsychology of domestic violence: a comparative preliminary study of executive functioning.

    Science.gov (United States)

    Becerra-García, Juan Antonio

    2015-01-01

    In neuropsychological studies of executive functioning in domestic violence offenders, the different investigations conducted have only studied differences within this group or in relation to control groups of non-offenders. To minimize the limitations in relation to comparison groups, the purpose of this study was to compare executive functioning in domestic violence offenders in relation to different groups of offenders (i.e. sexual, violent and non-violent) and a control group of non-offenders, with all groups matched on socio-demographic and clinical characteristics. Executive functioning was tested of all participants with the Trail Making Test (direct and derived scores). Compared with the control group, the domestic violence offenders and sex offenders exhibited the poorest performance on the Trail Making Test part B (time) and on the B-A derived index; whereas, the violent offenders group (i.e. convicted of assault, wounding, homicide etc.) showed a high number of errors in part B. These findings suggest that domestic violence offenders exhibit similar performance on the TMT as sex offenders, where both have poorer cognitive flexibility and executive control. Other violent offenders exhibited different patterns of difficulty on this test (e.g. more impulsivity responses). Executive functioning may be a central psychological process that could help explain the interrelations between domestic and sexual aggression, and could be a relevant construct for common treatment of domestic batterers and sex offenders. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  6. Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomics

    Directory of Open Access Journals (Sweden)

    Anthony John Walker

    2014-07-01

    Full Text Available Eukaryotic protein kinases are well conserved through evolution. The genome of Schistosoma mansoni, which causes intestinal schistosomiasis, encodes over 250 putative protein kinases with all of the main eukaryotic groups represented. However, unraveling functional roles for these kinases is a considerable endeavour, particularly as protein kinases regulate multiple and sometimes overlapping cell and tissue functions in organisms. In this article, elucidating protein kinase signal transduction and function in schistosomes is considered from the perspective of the state-of-the-art methodologies used and comparative organismal biology, with a focus on current advances and future directions. Using the free-living nematode Caenorhabditis elegans as a comparator we predict roles for various schistosome protein kinases in processes vital for host invasion and successful parasitism such as sensory behaviour, growth and development. It is anticipated that the characterization of schistosome protein kinases in the context of parasite function will catalyze cutting edge research into host-parasite interactions and will reveal new targets for developing drug interventions against human schistosomiasis.

  7. Comparing Executive Function and Behavioral Inhibition in Schizophrenia, Bipolar Mood Disorder Type I and Normal Groups

    Directory of Open Access Journals (Sweden)

    Marziye Khodaee

    2015-11-01

    Full Text Available Introduction: Cognitive performance in patients with schizophrenia and Bipolar I disorder seems to be different from the normal individuals, that these defects affect their treatment results. Therefore, this study aimed to compare executive function and behavioral inhibition within patients suffering from schizophrenia, bipolar type I as well as a normal group. Methods: In this descriptive-comparative study, out of all patients hospitalized in daily psychiatric clinic in Najafabad in 2014 due to these disorders, 20 schizophrenia and 20 bipolar type I as well as 20 normal individuals were selected via the convinience sampling. All the study participants completed the computerizing tests including Tower of London and Go-No Go. The study data were analyzed utilizing SPSS software (ver 22 via MANOVA. Results: The study findings revealed a significant difference between the two patient groups and the normal group in regard with executive function and behavioral inhibition (p<0.05, whereas no differences were detected between schizophrenics and bipolar patient groups. Furthermore, patients suffering from schizophrenia and bipolar I mood disorder demonstrated significantly poor performance in cognitive function and behavioral inhibition compared to the normal group. Conclusion: The present study results can be significantly applied in pathology and therapy of these disorders, so as recognizing the inability of such patients can be effective in developing cognitive rehabilitation programs in these patients.

  8. Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls.

    Science.gov (United States)

    Varni, James W; Shulman, Robert J; Self, Mariella M; Nurko, Samuel; Saps, Miguel; Saeed, Shehzad A; Bendo, Cristiane B; Patel, Ashish S; Dark, Chelsea Vaughan; Zacur, George M; Pohl, John F

    2015-09-01

    Patient-reported outcome (PRO) measures of gastrointestinal symptoms are recommended to determine treatment effects for irritable bowel syndrome (IBS) and functional abdominal pain (FAP). Study objectives were to compare the symptom profiles of pediatric patients with IBS or FAP with healthy controls and with each other using the PedsQL Gastrointestinal Symptoms and Gastrointestinal Worry Scales, and to establish clinical interpretability of PRO scale scores through identification of minimal important difference (MID) scores. Gastrointestinal Symptoms and Worry Scales were completed in a 9-site study by 154 pediatric patients and 161 parents (162 families; IBS n = 46, FAP n = 119). Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were administered along with Gastrointestinal Worry Scales. A matched sample of 447 families with healthy children completed the scales. Gastrointestinal Symptoms and Worry Scales distinguished between patients with IBS or FAP compared with healthy controls (P 1.50) for symptoms indicative of IBS or FAP, demonstrating a broad multidimensional gastrointestinal symptom profile and clinical interpretability with MID scores for individual PRO scales. Patients with IBS manifested more symptoms of constipation, gas and bloating, and diarrhea than patients with FAP. Patients with IBS or FAP manifested a broad gastrointestinal symptom profile compared with healthy controls with large differences, indicating the critical need for more effective interventions to bring patient functioning within the range of healthy functioning.

  9. A comparative study of sexual function, behavior, and cognitions of women with lifelong vaginismus.

    Science.gov (United States)

    Cherner, Rebecca A; Reissing, Elke D

    2013-11-01

    Vaginismus is classified as a sexual dysfunction, yet limited research is available on the sexual function and behavior of women with this condition. Comparing women with lifelong vaginismus to women with lifelong dyspareunia and women with no pain during intercourse, this study explored sexual function, anxiety, and behavior along with cognitions related to vaginal penetration. A total of 152 women completed an online survey that included a series of validated questionnaires. Main findings indicated that, relative to both comparison groups, women in the vaginismus group reported a more limited range of sexual behavior across the lifespan and more maladaptive cognitions related to fear of losing control of one's body and the situation during penetration. Compared to the no-pain group, both symptomatic groups reported more difficulties across several indicators of sexual function, more limited sexual behavior in the past year and past month, and more maladaptive cognitions related to vaginal penetration. However, women with vaginismus reported more sexual desire and less difficulty with lubrication compared to women with dyspareunia. Numerous sexual problems extending beyond vaginal penetration difficulties were confirmed, suggesting a need for broader treatment approaches not limited to the experience of vaginal penetration. Results were discussed as they relate to the fear-avoidance model of vaginismus.

  10. Molecular profiling--a tool for addressing emerging gaps in the comparative risk assessment of GMOs.

    Science.gov (United States)

    Heinemann, Jack A; Kurenbach, Brigitta; Quist, David

    2011-10-01

    Assessing the risks of genetically modified organisms (GMOs) is required by both international agreement and domestic legislation. Many view the use of the "omics" tools for profiling classes of molecules as useful in risk assessment, but no consensus has formed on the need or value of these techniques for assessing the risks of all GMOs. In this and many other cases, experts support case-by-case use of molecular profiling techniques for risk assessment. We review the latest research on the applicability and usefulness of molecular profiling techniques for GMO risk assessment. As more and more kinds of GMOs and traits are developed, broader use of molecular profiling in a risk assessment may be required to supplement the comparative approach to risk assessment. The literature-based discussions on the use of profiling appear to have settled on two findings: 1. profiling techniques are reliable and relevant, at least no less so than other techniques used in risk assessment; and 2. although not required routinely, regulators should be aware of when they are needed. The dismissal of routine molecular profiling may be confusing to regulators who then lack guidance on when molecular profiling might be worthwhile. Molecular profiling is an important way to increase confidence in risk assessments if the profiles are properly designed to address relevant risks and are applied at the correct stage of the assessment. Copyright © 2011 Elsevier Ltd. All rights reserved.

  11. Effects of acute organophosphate ingestion on cognitive function, assessed with the mini mental state examination

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    S S Jayasinghe

    2012-01-01

    Full Text Available Background : Chronic damage to the central nervous system resulting in cognitive impairment has been shown with repeated, low doses of organophosphorus (OP exposure over month or years. Aim: The study aimed to find out whether there is any cognitive impairment following acute OP exposure that could be detected by a simple screening instrument, the Mini Mental State Examination (MMSE, in clinical settings. Settings and Design: A cohort study. Materials and Methods: The study was conducted with matched controls. Consecutive patients admitted to the hospital with acute ingestion of OP were recruited. Cognitive function was assessed with the MMSE, digit span test, test of long-term memory function and concentration. Patients were assessed twice: at 1 and 6 weeks of exposure. Statistical Analysis: Continuous variables were analyzed with the paired and unpaired T-tests. Non-normally distributed data were analyzed with the Mann-Whitney U test and Wilcoxon Signed Rank test. Discrete variables were analyzed with the Chi-square test. Results: There were 60 patients and 61 controls. The mean age (SD of the patients and controls was 31.5 (11.6 and 31.3 (11.8 years, respectively. Forty-two patients turned up for the second assessment. Significant impairment of cognitive function was seen in the total score of MMSE (95% CI -2.5 to -0.3, orientation (95% CI -1 to -0.2 and language (95% CI -0.9 to -0.1 domains of MMSE, digit span test (95% CI 0.1-1.7 and test of long-term memory function (95% CI 0.3-2.3 in the first assessment compared with the controls. When the results of the second assessment were compared with the controls, no significant differences were seen. Conclusion: Although there was a slight transient cognitive impairment detected with the screening tests following acute OP ingestion, no long-term cognitive defects was detected.

  12. Comparative Risk Assessment to Inform Adaptation Priorities for the Natural Environment: Observations from the First UK Climate Change Risk Assessment

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    Iain Brown

    2015-11-01

    Full Text Available Risk assessment can potentially provide an objective framework to synthesise and prioritise climate change risks to inform adaptation policy. However, there are significant challenges in the application of comparative risk assessment procedures to climate change, particularly for the natural environment. These challenges are evaluated with particular reference to the first statutory Climate Change Risk Assessment (CCRA and evidence review procedures used to guide policy for the UK government. More progress was achieved on risk identification, screening and prioritisation compared to risk quantification. This was due to the inherent complexity and interdependence of ecological risks and their interaction with socio-economic drivers as well as a climate change. Robust strategies to manage risk were identified as those that coordinate organisational resources to enhance ecosystem resilience, and to accommodate inevitable change, rather than to meet specific species or habitats targets. The assessment also highlighted subjective and contextual components of risk appraisal including ethical issues regarding the level of human intervention in the natural environment and the proposed outcomes of any intervention. This suggests that goals for risk assessment need to be more clearly explicated and assumptions on tolerable risk declared as a primer for further dialogue on expectations for managed outcomes. Ecosystem-based adaptation may mean that traditional habitats and species conservation goals and existing regulatory frameworks no longer provide the best guide for long-term risk management thereby challenging the viability of some existing practices.

  13. Protective effect of anti-oxidants on endothelial function in young Korean-Asians compared to Caucasians

    Science.gov (United States)

    Yim, Jongeun; Petrofsky, Jerrold; Berk, Lee; Daher, Noha; Lohman, Everett; Moss, Abigail; Cavalcanti, Paula

    2012-01-01

    Summary Background Previous studies show that Asians have an impaired blood flow response (BFR) to occlusion after a single high fat (HF) meal. The mechanism is believed to be the presence and susceptibility to high free radicals in their blood. The free radical concentration after a HF meal has not been examined in Asians. Further the BFR to heat after a single HF meal in Koreans has not been measured. Material/Methods This study evaluated postprandial endothelial function by measuring the BFR to vascular occlusion and local heat before and after a HF meal and the interventional effects of anti-oxidant vitamins on improving endothelial function in young Korean-Asians (K) compared to Caucasians (C) with these assessments. Ten C and ten K participated in the study (mean age 25.3±3.6 years old). BFR to vascular occlusion and local heat and oxidative stress were assessed after a single low fat (LF) and HF meal at 2 hours compared to baseline. After administration of vitamins (1000 mg of vitamin C, 800 IU of vitamin E, and 300 mg of Coenzyme Q-10) for 14 days, the same measurements were made. Results This study showed that the skin BFR to vascular occlusion and local heat following a HF meal significantly decreased and free radicals significantly increased at 2 hours compared to baseline in K (pvitamins were given, the BFR to vascular occlusion and local heat before and after HF meal were not significantly different in K and C. Conclusions These findings suggest that even a single HF meal can reduce endothelial response to stress through an oxidative stress mechanism but can be blocked by antioxidants, probably through scavenging free radicals in K. Since endothelial function improved even before a HF meal in K, endothelial damage from an Americanized diet may be reduced in K by antioxidants. PMID:22847195

  14. COMPARATIVE ANALYSIS OF BEHAVIOURS RELATED TO FUNCTIONAL FOODS AMONG SELECTED YOUNG CONSUMERS IN POLAND AND GERMANY

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    Magdalena Zegan

    2016-12-01

    Full Text Available Nutrition is one of the key factors infl uencing human health. Consuming foods that either naturally contain or have been enriched with bioactive substances may aid the organism’s proper development and functioning and, most importantly, be a vital element in the prophylaxis of many non-communicable diseases as well as improve general sense of well-being. The aim of the study was to compare behaviours related to functional foods among a selected group of young people. The survey was conducted among 153 purposively selected young consumers from Poland and Germany in March/April 2015. An original survey questionnaire was employed. IBM SPSS Statistics ver. 23 software was used for statistical analysis (chi-squared test p < 0.05. The term “functional foods” was largely unknown among the respondents. A defi nite majority of the survey participants reported having bought and consumed products that, in fact, belong to this group of foods. The main source of information on the topic of functional foods was the Internet. While buying these products, respondents from both countries chiefl y took into account the price, the quality and the list of ingredients. The results point to the need to popularize information about functional foods using trustworthy sources, in order to foster nutritional awareness. Consumer knowledge is the basis for the positive perception and acceptance of health-promoting foods and for making rational dietary choices. 

  15. The Internet and Generalized Functions of the Public Sphere: Transformative Potentials From a Comparative Perspective

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    Adrian Rauchfleisch

    2016-04-01

    Full Text Available Almost since the advent of the Internet, there has been great interest in analyzing and understanding online communication from the perspective of public sphere theory. The question of whether the properties of the Internet and, specifically, social media actually contribute to the public sphere is the matter of ongoing and somewhat heated scientific debate. The aim of the article is twofold. First, we propose a hierarchical model of generalized functions of public sphere. On a theoretical level, we interweave different strands of thought on the public sphere, and the resulting model is more inclusive and less rigid than each of those strands on their own. We identify four generalized functions: identity building, agenda-setting, control and criticism, and deliberation. The Internet does not contribute equally to these functions and we evaluate the impact of the Internet on each of these functions as a diminishing marginal utility. Second, we empirically explore the plausibility of our model in a global comparative analysis with focus on the Internet. With the help of macro-level variables which indicate the structural preconditions for a public sphere, we identify the highest possible function of the public sphere for each country to which the Internet can potentially contribute. Based on this approach, future research can be contextualized: case-study-based research can plausibly articulate expectations regarding the impact of the Internet on the public sphere.

  16. MicrobesOnline: an integrated portal for comparative and functional genomics

    Energy Technology Data Exchange (ETDEWEB)

    Dehal, Paramvir; Joachimiak, Marcin; Price, Morgan; Bates, John; Baumohl, Jason; Chivian, Dylan; Friedland, Greg; Huang, Kathleen; Keller, Keith; Novichkov, Pavel; Dubchak, Inna; Alm, Eric; Arkin, Adam

    2011-07-14

    Since 2003, MicrobesOnline (http://www.microbesonline.org) has been providing a community resource for comparative and functional genome analysis. The portal includes over 1000 complete genomes of bacteria, archaea and fungi and thousands of expression microarrays from diverse organisms ranging from model organisms such as Escherichia coli and Saccharomyces cerevisiae to environmental microbes such as Desulfovibrio vulgaris and Shewanella oneidensis. To assist in annotating genes and in reconstructing their evolutionary history, MicrobesOnline includes a comparative genome browser based on phylogenetic trees for every gene family as well as a species tree. To identify co-regulated genes, MicrobesOnline can search for genes based on their expression profile, and provides tools for identifying regulatory motifs and seeing if they are conserved. MicrobesOnline also includes fast phylogenetic profile searches, comparative views of metabolic pathways, operon predictions, a workbench for sequence analysis and integration with RegTransBase and other microbial genome resources. The next update of MicrobesOnline will contain significant new functionality, including comparative analysis of metagenomic sequence data. Programmatic access to the database, along with source code and documentation, is available at http://microbesonline.org/programmers.html.

  17. MicrobesOnline: an integrated portal for comparative and functional genomics

    Energy Technology Data Exchange (ETDEWEB)

    Dehal, Paramvir S.; Joachimiak, Marcin P.; Price, Morgan N.; Bates, John T.; Baumohl, Jason K.; Chivian, Dylan; Friedland, Greg D.; Huang, Katherine H.; Keller, Keith; Novichkov, Pavel S.; Dubchak, Inna L.; Alm, Eric J.; Arkin, Adam P.

    2009-09-17

    Since 2003, MicrobesOnline (http://www.microbesonline.org) has been providing a community resource for comparative and functional genome analysis. The portal includes over 1000 complete genomes of bacteria, archaea and fungi and thousands of expression microarrays from diverse organisms ranging from model organisms such as Escherichia coli and Saccharomyces cerevisiae to environmental microbes such as Desulfovibrio vulgaris and Shewanella oneidensis. To assist in annotating genes and in reconstructing their evolutionary history, MicrobesOnline includes a comparative genome browser based on phylogenetic trees for every gene family as well as a species tree. To identify co-regulated genes, MicrobesOnline can search for genes based on their expression profile, and provides tools for identifying regulatory motifs and seeing if they are conserved. MicrobesOnline also includes fast phylogenetic profile searches, comparative views of metabolic pathways, operon predictions, a workbench for sequence analysis and integration with RegTransBase and other microbial genome resources. The next update of MicrobesOnline will contain significant new functionality, including comparative analysis of metagenomic sequence data. Programmatic access to the database, along with source code and documentation, is available at http://microbesonline.org/programmers.html.

  18. Methodology for comparative assessment of various electricity generation systems using health and environmental impacts as the indicators

    International Nuclear Information System (INIS)

    Takahara, Shogo; Homma, Toshimitsu; Matsuki, Yoshio; Muramatsu, Ken

    2010-12-01

    This report describes the procedure of the comparative risk assessment, which is the standard approach to compare health and environmental impacts of different electricity generation systems, together with the results of the assessments and the international consensus. While there are several approaches to compare the impacts, the Impact Pathway (Damage Function) Approach is known as a popular method. This approach is characterized as the methodology that considers the emissions from power plants and the other sources, the dispersions of those pollutants, and then the impacts to the recipients of the pollutants; while, the scope of the assessments, such as types of the fuel chains as well as the time and the space of the impacts, needs to be defined upon the purpose, and the data and the model need to be justified through the process of the assessment. This approach was examined at the Coordinated Research Programme (hereinafter, 'CRP), which the International Atomic Energy Agency (hereinafter, 'IAEA) implemented with the research institutes of 12 countries on the comparative risk assessment. Upon the results of the assessments made by the CRP of the IAEA and the ExternE of the European Commission (hereinafter 'EC'), it is concluded that the impacts of the fossil fuel (coal, oil and natural gas) chains are relatively larger than of the other fuel chains, especially when the secondary chemical transformation of the pollutants and the effects of global warming are considered. On the contrary, the impacts of nuclear fuel cycle are smaller than of the fossil fuel chains'; although, there are still needs for further consensus building on the risks of the severe accidents and on the impacts of long-lived radio-nuclides spreading on the global level. (author)

  19. Comparative assessment of the environmental impact of wastes from electricity generation systems

    International Nuclear Information System (INIS)

    Torres, C.; Smith, G.M.; Linsley, G.; Hossain, S.

    1994-01-01

    The paper describes an outline methodology for assessing and comparing the environmental impact arising from management of the wastes from nuclear and other electricity generation systems. The assessment framework is applicable to wastes from all generation systems, including nuclear, fossil and renewable fuel systems, and can also be applied to the management of mixed hazardous waste. The major energy technologies in terms of waste production can be classified according to three major categories of fuels: fossil, nuclear and renewable. The emphasis in this description is on nuclear utility low-level and mixed wastes and waste streams. The methodology may be used to support the project on Data Bases and Methodologies for Comparative Assessment of Different Energy Sources for Electricity Generation (DECADES project, (2)) which is being developed by the International Atomic Energy Agency in collaboration with other international agencies. The DECADES project has the overall objective to improve the abilities for comparative assessment of energy chains for electricity generation. The objective of a methodology such as that described here is to ensure that waste management aspects are included effectively in comparative assessments of energy systems. This paper discusses the waste strams arising from nuclear power plants

  20. Pulmonary function in women: comparative analysis of conventional versus single-port laparoscopic cholecystectomy

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    MARISA DE CARVALHO BORGES

    2018-05-01

    Full Text Available ABSTRACT Objective: to evaluate the pulmonary function of women submitted to conventional and single-port laparoscopic cholecystectomy. Methods: forty women with symptomatic cholelithiasis, aged 18 to 70 years, participated in the study. We divided the patients into two groups: 21 patients underwent conventional laparoscopic cholecystectomy, and 19, single-port laparoscopic cholecystectomy. We assessed pulmonary function through forced vital capacity (FVC, forced expiratory volume in the first second (FEV1, and the FEV1/FVC ratio, measured before and 24 hours after the procedure. Results: in both groups, FVC and FEV1 were lower in the postoperative period than those obtained in the preoperative period, with a greater reduction in the group undergoing conventional laparoscopic cholecystectomy. Regarding the FEV1/FVC (% values, there was no statistically significant difference in any of the groups or times analyzed. Conclusion: there was a greater decline in FVC and FEV1 in the postoperative group of patients submitted to conventional laparoscopic cholecystectomy.

  1. Cognitive functions in methamphetamine induced psychosis compared to schizophrenia and normal subjects.

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    Zahra Ezzatpanah

    2014-09-01

    Full Text Available The purpose of this research was to study the cognitive functions in patients with methamphetamine-induced psychosis (MIP in comparison with schizophrenia patients and normal subjects.This was a cross-sectional study, 30 patients with MIP, 30 patients with schizophrenia and 30 normal individuals were selected via convenient sampling and were matched on age, sex and education. Wisconsin Cards Sorting, Stroop, Visual Search and Attention and Wechsler Memory Tests were used to assess the subjects.The study showed that patients with MIP and schizophrenia have more deficits in executive functions, selective attention, sustained attention and memory than normal subjects. There were no significant differences in cognitive functions between patients with MIP and schizophrenia except for visual search and attention that showed more impairment in patients with schizophrenia.Although, cognitive dysfunctions of patients with MIP are mostly similar to patients with schizophrenia, some differences seem to exist, especially in those functions that are not primarily dependent on frontal lobe.

  2. Modern needs in health technology assessment: a study of comparative effectiveness

    Directory of Open Access Journals (Sweden)

    A. V. Pavlysh

    2013-01-01

    Full Text Available Health technology assessment is a key component of healthcare decision making in most of the developed countries. Comparative effectiveness research as one of the elements of such assessment is becoming increasingly important in recent years. It is based on the effectiveness analysis of health technologies in real clinical practice setting. The authors have analyzed publications dedicated to these issues and showed the main methods of such study, its peculiarities, advantages and disadvantages. It has been revealed that the most frequently used designs of expert analysis are observational and pragmatic randomized studies. The main recommendations on analyzing comparative effectiveness are given in view of the literary data.

  3. Acceptability of Functional Behavioral Assessment Procedures to Special Educators and School Psychologists

    Science.gov (United States)

    O'Neill, Robert E.; Bundock, Kaitlin; Kladis, Kristin; Hawken, Leanne S.

    2015-01-01

    This survey study assessed the acceptability of a variety of functional behavioral assessment (FBA) procedures (i.e., functional assessment interviews, rating scales/questionnaires, systematic direct observations, functional analysis manipulations) to a national sample of 123 special educators and a state sample of 140 school psychologists.…

  4. LEFT ATRIAL FUNCTION: MODERN ASSESSMENT METHODS AND CLINICAL SIGNIFICANCE

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    E. N. Pavlyukova

    2017-01-01

    Full Text Available Assessment of the left atrial (LA function is important aspect of comprehensive cardiovascular system estimation. Many cardiac diseases make an impact to LA work either by direct affect on myocardium or hemodynamic condition changing. It is considered, LA and left ventricle diastolic pressure is interrelated, thus without mitral valve disease LA expanding is a sign of LV filling pressure augmentation. Examination of LA size and function by analysis of atrial reservoir, conduit, and booster pump can predict cardiovascular outcomes in patients with cardiomyopathy, ischemic heart disease and valvular heart disease. The last two decades gave new technologies to accurate and comprehensive LA mechanics estimation, in the first place related to tissue Doppler imaging. Atrial strain and strain rate obtained using two-dimensional speckle-tracking echocardiography have proved to be feasible and reproducible techniques to evaluate LA mechanics.In physiological settings, LA is a highly expandable chamber with relatively low pressures. However in the presence of acute and chronic injury, LA wall stretches. LA stretching is a hallmark of structure changing with myocardial fibrosis and has influence on LA strain and strain rate. LA strain estimation could be useful in the prediction of sinus rhythm restoration and maintenance after cardioversion and catheter ablation. Low values of global longitudinal LA strain indicate irreversible LA remodeling and are related to the atrial fibrillation progression from paroxysmal to permanent forms. The most interesting in these circumstances is the potential contribution of echocardiography to thromboembolic risk stratification in atrial fibrillation and invasive procedures such as atrial ablation. Therefore, at present, the main task is to understand the ways of clinical application of data  obtained during the LA study.

  5. Assessment of Family Functionality Among the Elderly With Chronic Illness

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    Claudia Balula Chaves

    2013-12-01

    Full Text Available The family APGAR scale was developed by Smilkstein, Ashworth, and Montano (1982. The satisfaction assessment of the elderly with chronic illness regarding family is essential. This study aims to describe the socio-demographic and clinical profile of elderly people with chronic illness and correlate with perceived family support. This is a cross-sectional, analytical study of 294 elderly people (51.4% female, patients at the Health Centre in the district of Viseu - Portugal, diagnosed with chronic illness (77.9% cardiovascular; Mean age was 72.22 ± 6.13, 70.7% were married and 52% had 4 years of schooling; Data was gathered using a questionnaire and the Family APGAR (Adaptation, Partnership, Growth, Affection and Resolve. In relation to family functionality, 18.7% perceive families as highly functional, 26.9% mildly dysfunctional and 54.4% severely dysfunction. There is a statistically significant relationship between the family APGAR and the presence of chronic illness (p < 0.001. We found no statistical significance between the family APGAR and gender (p = 0.26, age (p = 0.26, marital status (p = 0.32 and educational level (p = 0.28. Economic, political and social changes in our society has an impact on the family and the support they provide which is manifested among vulnerable groups, as is the case of an elderly person with chronic illness. Thus, we propose specialised psychological support for this age group which is more vulnerable and without the needed support from within the family.

  6. Guidelines for rating Global Assessment of Functioning (GAF

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    Aas IH Monrad

    2011-01-01

    Full Text Available Abstract Background Global Assessment of Functioning (GAF is a scoring system for the severity of illness in psychiatry. It is used clinically in many countries, as well as in research, but studies have shown several problems with GAF, for example concerning its validity and reliability. Guidelines for rating are important. The present study aimed to identify the current status of guidelines for rating GAF, and relevant factors and gaps in knowledge for the development of improved guidelines. Methods A thorough literature search was conducted. Results Few studies of existing guidelines have been conducted; existing guidelines are short; and rating has a subjective element. Seven main categories were identified as being important in relation to further development of guidelines: (1 general points about guidelines for rating GAF; (2 introduction to guidelines, with ground rules; (3 starting scoring at the top, middle or bottom level of the scale; (4 scoring for different time periods and of different values (highest, lowest or average; (5 the finer grading of the scale; (6 different guidelines for different conditions; and (7 different languages and cultures. Little information is available about how rules for rating are understood by different raters: the final score may be affected by whether the rater starts at the top, middle or bottom of the scale; there is little data on which value/combination of GAF values to record; guidelines for scoring within 10-point intervals are limited; there is little empirical information concerning the suitability of existing guidelines for different conditions and patient characteristics; and little is known about the effects of translation into different languages or of different cultural understanding. Conclusions Few studies have dealt specifically with guidelines for rating GAF. Current guidelines for rating GAF are not comprehensive, and relevant points for new guidelines are presented. Theoretical and

  7. Balance Functional Assessment in People with Visual Impairment

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    Rutkowska Izabela

    2015-12-01

    Full Text Available The aims of this study were twofold: to assess the level of balance of people with visual impairment against the BOT-2 standard scores for the able-bodied, and to identify in which trials subjects had the greatest difficulties in maintaining balance with respect to the degree of vision loss and age categories. One hundred twenty-seven subjects with visual impairment aged 6-16 years, participated in the study (68 girls and 59 boys. The division for partially sighted people (61 and the blind (66 was made according to the WHO classification. Functional balance assessment was made using a balance subtest from the Bruininks-Oseretsky test. Significant relationships were noticed between age and the level of balance (χ2 = 8.35 p <0,05, as well as between the degree of vision loss and the level of balance (χ2 = 24.53 p <0,001. The level of balance of almost all blind subjects was below (20% or well-below (60% the average for the able-bodied. The subjects’ ability to maintain balance was not dependent on gender and was associated primarily with the degree of visual impairment and age. Partially sighted people had better balance than the blind and the decrease in visual acuity resulted in reduction of balance skills. The lowest level of balance was observed in blind students aged 7-11 years. Elaborating physical fitness improvement programs for children and adolescents with visual impairment, diversity of age, the degree of vision loss and limitations of ablility to maintain balance should be taken into account.

  8. Assessment of executive function in adolescence: a comparison of traditional and virtual reality tools.

    Science.gov (United States)

    Lalonde, Gabrielle; Henry, Mylène; Drouin-Germain, Anne; Nolin, Pierre; Beauchamp, Miriam H

    2013-09-30

    Paper-pencil type tests are traditionally used in the assessment of executive functions (EF); however, concerns have been raised as to whether these represent actual functioning in everyday life. Virtual reality (VR) environments offer a novel alternative for the assessment of cognitive function and therefore have the potential to enhance the evaluation of EF by presenting individuals with stimuli that come closer to reproducing everyday situations. The aims of this study were to (1) establish which traditional paper-pencil EF tests from the Delis-Kaplan Executive Function System (D-KEFS) are associated with performance on a VR-Stroop task and (2) compare D-KEFS tests and the VR-Stroop task in their ability to predict everyday EF and behavior, as measured by the Behavioral Rating Inventory of Executive Function (BRIEF) and the Child Behavior Checklist (CBCL). Thirty-eight typically developing adolescents aged between 13 and 17 years completed the ClinicaVR: Classroom-Stroop, and five D-KEFS subtests (Trail Making, Tower, Twenty Questions, Verbal Fluency and Color-Word Interference). Their parents completed the BRIEF and CBCL questionnaires. The results indicate that performance on the VR-Stroop task correlates with both traditional forms of EF assessment (D-KEFS, BRIEF). In particular, performance on the VR-Stroop task was closely associated with performance on a paper-pencil inhibition task. Furthermore, VR-Stroop performance more accurately reflected everyday behavioral EF than paper-pencil tasks. VR appears to offer an ecological perspective on everyday functioning and could be seen as complementary to traditional tests in the assessment of complex cognitive abilities. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. THE COMPARATIVE ANALYSIS OF RENAL FUNCTION IN LIVER DISEASES USING COCKCROFT-GAULT FORMULAE AND CREATININE CLEARANCE

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    Karem Ravi Teja

    2018-01-01

    Full Text Available BACKGROUND Kidney dysfunction in liver disease can be due to different aetiologies and can have diverse manifestations. Most of the abnormalities of kidney function in cirrhosis are of functional origin namely, sodium retention, impaired free water excretion and renal vasoconstriction with decrease in renal perfusion and glomerular filtration rate. Renal dysfunction in chronic liver disease usually follows a progressive course- the final phase being Hepatorenal Syndrome (HRS. MATERIALS AND METHODS This study included patients with chronic liver disease being treated as inpatients in the Department of General Medicine, Konaseema Institute of Medical Sciences, Amalapuram. Evidence for chronic liver disease being defined by a compatible clinical profile (signs of liver cell failure or reduced liver span along with biochemical (altered liver function tests, reversal of albuminglobulin ratio or sonographic evidence (altered echotexture of liver or tissue diagnosis (positive liver biopsy for cirrhosis. RESULTS Eighteen percent, i.e. 5 out of the 28 patients with creatinine clearance more than 60 mL/minute by Cockcroft-Gault formula were found to have creatinine clearance values less than 40 mL/minute when done by timed urine collection P value calculated was found to be less than 0.0001, which is statistically significant. CONCLUSION In chronic liver disease, serum creatinine alone is not a reliable marker to assess renal dysfunction. Calculating creatinine clearance by using Cockcroft-Gault formula overestimates renal function in cirrhotics. Creatinine clearance measured by timed urine collections should be done routinely to assess renal reserve in advanced liver disease. Alcoholism appears to have adverse effect on renal function when compared with other aetiologies of cirrhosis.

  10. Comparative functional expression of nAChR subtypes in rodent DRG neurons.

    Science.gov (United States)

    Smith, Nathan J; Hone, Arik J; Memon, Tosifa; Bossi, Simon; Smith, Thomas E; McIntosh, J Michael; Olivera, Baldomero M; Teichert, Russell W

    2013-01-01

    We investigated the functional expression of nicotinic acetylcholine receptors (nAChRs) in heterogeneous populations of dissociated rat and mouse lumbar dorsal root ganglion (DRG) neurons by calcium imaging. By this experimental approach, it is possible to investigate the functional expression of multiple receptor and ion-channel subtypes across more than 100 neuronal and glial cells simultaneously. Based on nAChR expression, DRG neurons could be divided into four subclasses: (1) neurons that express predominantly α3β4 and α6β4 nAChRs; (2) neurons that express predominantly α7 nAChRs; (3) neurons that express a combination of α3β4/α6β4 and α7 nAChRs; and (4) neurons that do not express nAChRs. In this comparative study, the same four neuronal subclasses were observed in mouse and rat DRG. However, the expression frequency differed between species: substantially more rat DRG neurons were in the first three subclasses than mouse DRG neurons, at all developmental time points tested in our study. Approximately 70-80% of rat DRG neurons expressed functional nAChRs, in contrast to only ~15-30% of mouse DRG neurons. Our study also demonstrated functional coupling between nAChRs, voltage-gated calcium channels, and mitochondrial Ca(2) (+) transport in discrete subsets of DRG neurons. In contrast to the expression of nAChRs in DRG neurons, we demonstrated that a subset of non-neuronal DRG cells expressed muscarinic acetylcholine receptors and not nAChRs. The general approach to comparative cellular neurobiology outlined in this paper has the potential to better integrate molecular and systems neuroscience by uncovering the spectrum of neuronal subclasses present in a given cell population and the functionally integrated signaling components expressed in each subclass.

  11. Assessment of higher order structure comparability in therapeutic proteins using nuclear magnetic resonance spectroscopy.

    Science.gov (United States)

    Amezcua, Carlos A; Szabo, Christina M

    2013-06-01

    In this work, we applied nuclear magnetic resonance (NMR) spectroscopy to rapidly assess higher order structure (HOS) comparability in protein samples. Using a variation of the NMR fingerprinting approach described by Panjwani et al. [2010. J Pharm Sci 99(8):3334-3342], three nonglycosylated proteins spanning a molecular weight range of 6.5-67 kDa were analyzed. A simple statistical method termed easy comparability of HOS by NMR (ECHOS-NMR) was developed. In this method, HOS similarity between two samples is measured via the correlation coefficient derived from linear regression analysis of binned NMR spectra. Applications of this method include HOS comparability assessment during new product development, manufacturing process changes, supplier changes, next-generation products, and the development of biosimilars to name just a few. We foresee ECHOS-NMR becoming a routine technique applied to comparability exercises used to complement data from other analytical techniques. Copyright © 2013 Wiley Periodicals, Inc.

  12. SNUGB: a versatile genome browser supporting comparative and functional fungal genomics

    Directory of Open Access Journals (Sweden)

    Kim Seungill

    2008-12-01

    Full Text Available Abstract Background Since the full genome sequences of Saccharomyces cerevisiae were released in 1996, genome sequences of over 90 fungal species have become publicly available. The heterogeneous formats of genome sequences archived in different sequencing centers hampered the integration of the data for efficient and comprehensive comparative analyses. The Comparative Fungal Genomics Platform (CFGP was developed to archive these data via a single standardized format that can support multifaceted and integrated analyses of the data. To facilitate efficient data visualization and utilization within and across species based on the architecture of CFGP and associated databases, a new genome browser was needed. Results The Seoul National University Genome Browser (SNUGB integrates various types of genomic information derived from 98 fungal/oomycete (137 datasets and 34 plant and animal (38 datasets species, graphically presents germane features and properties of each genome, and supports comparison between genomes. The SNUGB provides three different forms of the data presentation interface, including diagram, table, and text, and six different display options to support visualization and utilization of the stored information. Information for individual species can be quickly accessed via a new tool named the taxonomy browser. In addition, SNUGB offers four useful data annotation/analysis functions, including 'BLAST annotation.' The modular design of SNUGB makes its adoption to support other comparative genomic platforms easy and facilitates continuous expansion. Conclusion The SNUGB serves as a powerful platform supporting comparative and functional genomics within the fungal kingdom and also across other kingdoms. All data and functions are available at the web site http://genomebrowser.snu.ac.kr/.

  13. Leveraging Comparative Genomics to Identify and Functionally Characterize Genes Associated with Sperm Phenotypes in Python bivittatus (Burmese Python

    Directory of Open Access Journals (Sweden)

    Kristopher J. L. Irizarry

    2016-01-01

    Full Text Available Comparative genomics approaches provide a means of leveraging functional genomics information from a highly annotated model organism’s genome (such as the mouse genome in order to make physiological inferences about the role of genes and proteins in a less characterized organism’s genome (such as the Burmese python. We employed a comparative genomics approach to produce the functional annotation of Python bivittatus genes encoding proteins associated with sperm phenotypes. We identify 129 gene-phenotype relationships in the python which are implicated in 10 specific sperm phenotypes. Results obtained through our systematic analysis identified subsets of python genes exhibiting associations with gene ontology annotation terms. Functional annotation data was represented in a semantic scatter plot. Together, these newly annotated Python bivittatus genome resources provide a high resolution framework from which the biology relating to reptile spermatogenesis, fertility, and reproduction can be further investigated. Applications of our research include (1 production of genetic diagnostics for assessing fertility in domestic and wild reptiles; (2 enhanced assisted reproduction technology for endangered and captive reptiles; and (3 novel molecular targets for biotechnology-based approaches aimed at reducing fertility and reproduction of invasive reptiles. Additional enhancements to reptile genomic resources will further enhance their value.

  14. Comparative assessment of the impact of national culture dimensions on traits of organization culture

    OpenAIRE

    Štreimikienė, Dalia; Mikalauskienė, Asta

    2012-01-01

    The paper deals with national culture and organizational culture assessment methods and applies the Denison Organization Culture Survey to measure organizational culture in Lithuanian SME in Kaunas region. The paper aims to define the impact of national culture dimensions on organizational culture dimensions by applying comparative analysis for Taiwan, Mexico and Lithuania. The comparative analysis revealed that power distance is positively related to involvement, but negatively related to th...

  15. Comparative assessment of the impact of national culture dimensions on traits of organization culture

    OpenAIRE

    Štreimikienė, Dalia; Mikalauskienė, Asta

    2013-01-01

    The paper deals with national culture and organizational culture assessment methods and applies the Denison Organization Culture Survey to measure organizational culture in Lithuanian SME in Kaunas region. The paper aims to define the impact of national culture dimensions on organizational culture dimensions by applying comparative analysis for Taiwan, Mexico and Lithuania. The comparative analysis revealed that power distance is positively related to involvement, but negatively related to th...

  16. Comparative Assessment to Danger of Rock Bursts Origin in Different Conditions of Mining in OKR

    OpenAIRE

    Bukovanský Stanislav

    1998-01-01

    For this comparative assessment to factual possibilities of balance failure it is necessary to investigate a character and possible changes in individual elements of the system "rock - time", as well as their mutual interaction with rock burst origin and their course. Research observations after burst show that the influence of strong energy after rock burst, into the overlying impact click is present in a coal seam due to its higher pressure to a face (when compared with a relevant pressure...

  17. Assessment of cardiac neuronal function with iodine-123 MIBG scintigraphy in children with idiopathic dilated cardiomyopathy

    International Nuclear Information System (INIS)

    Maunoury, Ch.; Sebahoun, St.; Hallaj, I.; Barritault, L.; Acar, Ph.; Sidi, D.; Kachaner, J.; Agostini, D.; Bouvard, G.

    2000-01-01

    The I-123 MIBG cardiac scintigraphy can assess norepinephrine uptake. It has been showed that cardiac adrenergic neuronal function was impaired in adults with dilated cardiomyopathy. The aim of this prospective study was to assess cardiac neuronal function in children with idiopathic dilated cardiomyopathy (DCM) and to compare cardiac uptake of I-123 MIBG with left ventricular ejection fraction (LVEF). We studied 26 consecutive patients with idiopathic DCM, aged 44 ± 50 months, and 12 controls, aged 49 ±65 months. A planar scintigraphy was performed in all children 4 hours after intravenous injection of 20 to 75 MBq of I-123 MIBG. A static anterior view was acquired for 10 minutes. Cardiac uptake of I-123 MIBG was expressed as the heart to mediastinum count ratio (HMR). Equilibrium radionuclide angiography was performed following a standard protocol. Cardiac uptake of I-123 MIBG was significantly decreased in patients with idiopathic DCM when compared with cardiac uptake in controls (172±34% vs 277±14%, P<0.0001. There was a good correlation between RCM and LVEF in patients with idiopathic DCM (y = 2.5 x +113.3, r = 0.80, P < 0.0001). In conclusion, cardiac neuronal function was impaired in children with idiopathic DCM and related to impairment of left ventricular function. (author)

  18. Comparative metagenomic analysis of plasmid encoded functions in the human gut microbiome

    Directory of Open Access Journals (Sweden)

    Marchesi Julian R

    2010-01-01

    Full Text Available Abstract Background Little is known regarding the pool of mobile genetic elements associated with the human gut microbiome. In this study we employed the culture independent TRACA system to isolate novel plasmids from the human gut microbiota, and a comparative metagenomic analysis to investigate the distribution and relative abundance of functions encoded by these plasmids in the human gut microbiome. Results Novel plasmids were acquired from the human gut microbiome, and homologous nucleotide sequences with high identity (>90% to two plasmids (pTRACA10 and pTRACA22 were identified in the multiple human gut microbiomes analysed here. However, no homologous nucleotide sequences to these plasmids were identified in the murine gut or environmental metagenomes. Functions encoded by the plasmids pTRACA10 and pTRACA22 were found to be more prevalent in the human gut microbiome when compared to microbial communities from other environments. Among the most prevalent functions identified was a putative RelBE toxin-antitoxin (TA addiction module, and subsequent analysis revealed that this was most closely related to putative TA modules from gut associated bacteria belonging to the Firmicutes. A broad phylogenetic distribution of RelE toxin genes was observed in gut associated bacterial species (Firmicutes, Bacteroidetes, Actinobacteria and Proteobacteria, but no RelE homologues were identified in gut associated archaeal species. We also provide indirect evidence for the horizontal transfer of these genes between bacterial species belonging to disparate phylogenetic divisions, namely Gram negative Proteobacteria and Gram positive species from the Firmicutes division. Conclusions The application of a culture independent system to capture novel plasmids from the human gut mobile metagenome, coupled with subsequent comparative metagenomic analysis, highlighted the unexpected prevalence of plasmid encoded functions in the gut microbial ecosystem. In

  19. Comparing health locus of control in patients with Spasmodic Dysphonia, Functional Dysphonia and Nonlaryngeal Dystonia.

    Science.gov (United States)

    Haselden, Karen; Powell, Theresa; Drinnan, Mike; Carding, Paul

    2009-11-01

    Locus of Control (LoC) refers to an individuals' perception of whether they are in control of life events. Health Locus of Control refers to whether someone feels they have influence over their health. Health Locus of Control has not been studied in any depth in voice-disordered patients. The objective of this study was to examine Health Locus of Control in three patient groups: (1) Spasmodic Dysphonia, (2) Functional Dysphonia and (3) a nondysphonic group with Nonlaryngeal Dystonia. LoC was measured and compared in a total of 57 patients using the Multidimensional Health Locus of Control Scales (diagnostic specific) Form C. Internal, Chance, and Powerful others LoC were measured and comparisons were made using one-way analysis of variance. Contrary to expectations Internal LoC was found to be significantly higher in the Functional Dysphonia group when compared to the other two groups. There was no significant difference between the groups in Chance or Powerful others LoC. The two organic groups, Spasmodic Dysphonia and Nonlaryngeal Dystonia, were more alike in Internal Health Locus of Control than the Functional Dysphonia group. The diagnostic nature of the groups was reflected in their LoC scores rather than their voice loss. These results contribute to the debate about the etiology of Spasmodic Dysphonia and will be of interest to those involved in the psychology of voice and those managing voice-disordered patients.

  20. Varicocele is associated with hypogonadism and impaired erectile function: a prospective comparative study.

    Science.gov (United States)

    Ji, B; Jin, X-B

    2017-08-01

    We conducted this prospective comparative study to examine the hypothesis that varicocele was associated with hypogonadism and impaired erectile function as reflected in International Index of Erectile Function-5 (IIEF-5) scores as well as nocturnal penile tumescence and rigidity (NPTR) parameters. From December 2014 to December 2015, a total of 130 males with varicocele complaining of infertility or scrotal discomfort and 130 age-matched healthy males chosen from volunteer healthy hospital staff as controls were recruited in this study. Serum testosterone (TT) levels and IIEF-5 scores as well as NPTR parameters were evaluated and compared between varicocele and control subjects. All participants were further grouped into hypogonadism based on the cut-off value 300 ng/dL. A total of 45 of 130 patients were identified as hypogonadism, while it was not found in control subjects. A multivariate logistic regression with likelihood ratio test revealed that TT levels as well as grade III and II varicocele posed significant indicators for hypogonadism occurrence (chi-square of likelihood ratio = 12.40, df = 3, p hypogonadism was confirmed in this study and an impaired erectile function correlated with TT levels and infertility duration was also observed. © 2016 Blackwell Verlag GmbH.

  1. 99mTc-GSA dynamic SPECT for regional hepatic functional reserve estimation. Assessment of quantification

    International Nuclear Information System (INIS)

    Hwang, Eui-Hyo

    1999-01-01

    The aim of this study is the assessment of the physiological implication of estimated parameters and the clinical value of this analyzing method for hepatic functional reserve estimation. After venous injection of 185 MBq of GSA, fifteen sequential sets of SPECT data were acquired for 15 minutes. First 5 sets SPECT images were analyzed by Patlak plot and hepatic GSA clearance was obtained in each matrix. The sum of hepatic GSA clearance in each matrix (total hepatic GSA clearance) was calculated as an index of whole liver functional reserve. Total hepatic GSA clearance was compared with receptor index or effective blood flow (EHBF) of whole liver which were analyzed by Direct Integral Linear Least Square Regression (DILS) method for the assessment of the physiological implications of hepatic GSA clearance. The clinical value of total hepatic GSA clearance was assessed in comparisons with the conventional hepatic function test. A very good correlations were observed between total hepatic GSA clearance and receptor index, whereas the correlations between total hepatic GSA clearance and EHBF were not significant. Significant correlations were also observed between total hepatic GSA clearance and the conventional hepatic function tests, such as choline esterase, albumin, hepaplastin test, ICG R15. (K.H.)

  2. Refining Inquiry with Multi-Form Assessment: Formative and summative assessment functions for flexible inquiry

    Science.gov (United States)

    Zuiker, Steven; Reid Whitaker, J.

    2014-04-01

    This paper describes the 5E+I/A inquiry model and reports a case study of one curricular enactment by a US fifth-grade classroom. A literature review establishes the model's conceptual adequacy with respect to longstanding research related to both the 5E inquiry model and multiple, incremental innovations of it. As a collective line of research, the review highlights a common emphasis on formative assessment, at times coupled either with differentiated instruction strategies or with activities that target the generalization of learning. The 5E+I/A model contributes a multi-level assessment strategy that balances formative and summative functions of multiple forms of assessment in order to support classroom participation while still attending to individual achievement. The case report documents the enactment of a weeklong 5E+I/A curricular design as a preliminary account of the model's empirical adequacy. A descriptive and analytical narrative illustrates variable ways that multi-level assessment makes student thinking visible and pedagogical decision-making more powerful. In light of both, it also documents productive adaptations to a flexible curricular design and considers future research to advance this collective line of inquiry.

  3. Functional and Psychosocial Outcomes of Hand Transplantation Compared with Prosthetic Fitting in Below-Elbow Amputees: A Multicenter Cohort Study.

    Directory of Open Access Journals (Sweden)

    Stefan Salminger

    Full Text Available Hand-transplantation and improvements in the field of prostheses opened new frontiers in restoring hand function in below-elbow amputees. Both concepts aim at restoring reliable hand function, however, the indications, advantages and limitations for each treatment must be carefully considered depending on level and extent of amputation. Here we report our findings of a multi-center cohort study comparing hand function and quality-of-life of people with transplanted versus prosthetic hands.Hand function in amputees with either transplant or prostheses was tested with Action Research Arm Test (ARAT, Southampton Hand Assessment Procedure (SHAP and the Disabilities of the Arm, Shoulder and Hand measure (DASH. Quality-of-life was compared with the Short-Form 36 (SF-36.Transplanted patients (n = 5 achieved a mean ARAT score of 40.86 ± 8.07 and an average SHAP score of 75.00 ± 11.06. Prosthetic patients (n = 7 achieved a mean ARAT score of 39.00 ± 3.61 and an average SHAP score of 75.43 ± 10.81. There was no significant difference between transplanted and prosthetic hands in ARAT, SHAP or DASH. While quality-of-life metrics were equivocal for four scales of the SF-36, transplanted patients reported significantly higher scores in "role-physical" (p = 0.006, "vitality" (p = 0.008, "role-emotional" (p = 0.035 and "mental-health" (p = 0.003.The indications for hand transplantation or prosthetic fitting in below-elbow amputees require careful consideration. As functional outcomes were not significantly different between groups, patient's best interests and the route of least harm should guide treatment. Due to the immunosuppressive side-effects, the indication for allotransplantation must still be restrictive, the best being bilateral amputees.

  4. Assessment of Dengue Fever Severity Through Liver Function Tests

    International Nuclear Information System (INIS)

    Ahmed, A.; Alvi, A. H.; Nawaz, A. A.; Butt, A.; Hanif, A.

    2014-01-01

    Objective: To assess the utility of liver function tests (LFTs) for early recognition and prediction of severity of Dengue fever in hospitalized patients. Study Design: An analytical study. Place and Duration of Study: Services Institute of Medical Science and Fatima Memorial Hospital, Lahore, from September - December 2010. Methodology: Admitted cases of Dengue fever were divided into 3 groups; mild, moderate and severe increases in aminotransferases. Elevation in LFTs was co-related with good or bad outcome i.e. (survival or complication free stay) or (death or complications). Results were analyzed in SPSS version 18. Results: Out of the 353 patients with mean age of 37.12 +- 15.45 years, 245 (69.4%) were males and 108 (30.6%) were females. Seventy five patients (21.2%) had mild elevation of aminotransferases (2 fold increases), 265 patients (75.1%) had moderate increases (3 to 4 fold) and 13 (3.7%) had severe (> 4 fold increase). ALT was statistically higher in patients with septicemia, hepatic and renal failure (p-value 0.05). AST was higher in almost all complications. Prolonged hospital stay was associated with raised LFTs and greater complications and mortality. AST was found to be twice as much raised as ALT. Conclusion: AST and ALT were statistically higher in patients with worse outcome thus can lead to early recognition of high risk cases. (author)

  5. Functional brain response to food images in successful adolescent weight losers compared with normal-weight and overweight controls.

    Science.gov (United States)

    Jensen, Chad D; Kirwan, C Brock

    2015-03-01

    Research conducted with adults suggests that successful weight losers demonstrate greater activation in brain regions associated with executive control in response to viewing high-energy foods. No previous studies have examined these associations in adolescents. Functional neuroimaging was used to assess brain response to food images among groups of overweight (OW), normal-weight (NW), and successful weight-losing (SWL) adolescents. Eleven SWL, 12 NW, and 11 OW participants underwent functional magnetic resonance imaging while viewing images of high- and low-energy foods. When viewing high-energy food images, SWLs demonstrated greater activation in the dorsolateral prefrontal cortex (DLPFC) compared with OW and NW controls. Compared with NW and SWL groups, OW individuals demonstrated greater activation in the ventral striatum and anterior cingulate in response to food images. Adolescent SWLs demonstrated greater neural activation in the DLPFC compared with OW/NW controls when viewing high-energy food stimuli, which may indicate enhanced executive control. OW individuals' brain responses to food stimuli may indicate greater reward incentive processes than either SWL or NW groups. © 2015 The Obesity Society.

  6. Pragmatic and executive functions in traumatic brain injury and right brain damage: An exploratory comparative study

    Directory of Open Access Journals (Sweden)

    Nicolle Zimmermann

    Full Text Available Abstract Objective: To describe the frequency of pragmatic and executive deficits in right brain damaged (RBD and in traumatic brain injury (TBI patients, and to verify possible dissociations between pragmatic and executive functions in these two groups. Methods: The sample comprised 7 cases of TBI and 7 cases of RBD. All participants were assessed by means of tasks from the Montreal Communication Evaluation Battery and executive functions tests including the Trail Making Test, Hayling Test, Wisconsin Card Sorting Test, semantic and phonemic verbal fluency tasks, and working memory tasks from the Brazilian Brief Neuropsychological Assessment Battery NEUPSILIN. Z-score was calculated and a descriptive analysis of frequency of deficits (Z< -1.5 was carried out. Results: RBD patients presented with deficits predominantly on conversational and narrative discursive tasks, while TBI patients showed a wider spread pattern of pragmatic deficits. Regarding EF, RBD deficits included predominantly working memory and verbal initiation impairment. On the other hand, TBI individuals again exhibited a general profile of executive dysfunction, affecting mainly working memory, initiation, inhibition, planning and switching. Pragmatic and executive deficits were generally associated upon comparisons of RBD patients and TBI cases, except for two simple dissociations: two post-TBI cases showed executive deficits in the absence of pragmatic deficits. Discussion: Pragmatic and executive deficits can be very frequent following TBI or vascular RBD. There seems to be an association between these abilities, indicating that although they can co-occur, a cause-consequence relationship cannot be the only hypothesis.

  7. Evaluation of modulation transfer function of optical lens system by support vector regression methodologies - A comparative study

    Science.gov (United States)

    Petković, Dalibor; Shamshirband, Shahaboddin; Saboohi, Hadi; Ang, Tan Fong; Anuar, Nor Badrul; Rahman, Zulkanain Abdul; Pavlović, Nenad T.

    2014-07-01

    The quantitative assessment of image quality is an important consideration in any type of imaging system. The modulation transfer function (MTF) is a graphical description of the sharpness and contrast of an imaging system or of its individual components. The MTF is also known and spatial frequency response. The MTF curve has different meanings according to the corresponding frequency. The MTF of an optical system specifies the contrast transmitted by the system as a function of image size, and is determined by the inherent optical properties of the system. In this study, the polynomial and radial basis function (RBF) are applied as the kernel function of Support Vector Regression (SVR) to estimate and predict estimate MTF value of the actual optical system according to experimental tests. Instead of minimizing the observed training error, SVR_poly and SVR_rbf attempt to minimize the generalization error bound so as to achieve generalized performance. The experimental results show that an improvement in predictive accuracy and capability of generalization can be achieved by the SVR_rbf approach in compare to SVR_poly soft computing methodology.

  8. Efficacy of electroacupuncture compared with transcutaneous electric nerve stimulation for functional constipation: Study protocol for a randomized, controlled trial.

    Science.gov (United States)

    Zeng, Yuxiao; Zhang, Xuecheng; Zhou, Jing; Wang, Xinwei; Jiao, Ruimin; Liu, Zhishun

    2018-05-01

    To treat functional constipation, both electroacupuncture (EA) therapy and transcutaneous electric nerve stimulation (TENS) are safe and effective. However, no head-to-head comparison trial has been conducted. This trial compares the efficacy of electroacupuncture relative to transcutaneous electric nerve stimulation for functional constipation. Individuals with functional constipation will be randomly allocated to receive either EA or TENS (n = 51, each), 3 times per week for 8 weeks. The primary outcome is the percentage of participants with an average increase from baseline of 1 or more complete spontaneous bowel movements at week 8. The secondary outcome measures are the following: at the time of visits, changes in the number of complete spontaneous bowel movements, number of spontaneous bowel movements, stool character, difficulty in defecation, patients' assessment of quality of life regarding constipation (self-report questionnaire), and use of auxiliary defecation methods. The results of this trial should verify whether EA is more efficacious than TENS for relieving symptoms of functional constipation. The major limitation of the study is the lack of blinding of the participants and acupuncturist.

  9. Comparative functional characterization of the CSR-1 22G-RNA pathway in Caenorhabditis nematodes.

    Science.gov (United States)

    Tu, Shikui; Wu, Monica Z; Wang, Jie; Cutter, Asher D; Weng, Zhiping; Claycomb, Julie M

    2015-01-01

    As a champion of small RNA research for two decades, Caenorhabditis elegans has revealed the essential Argonaute CSR-1 to play key nuclear roles in modulating chromatin, chromosome segregation and germline gene expression via 22G-small RNAs. Despite CSR-1 being preserved among diverse nematodes, the conservation and divergence in function of the targets of small RNA pathways remains poorly resolved. Here we apply comparative functional genomic analysis between C. elegans and Caenorhabditis briggsae to characterize the CSR-1 pathway, its targets and their evolution. C. briggsae CSR-1-associated small RNAs that we identified by immunoprecipitation-small RNA sequencing overlap with 22G-RNAs depleted in cbr-csr-1 RNAi-treated worms. By comparing 22G-RNAs and target genes between species, we defined a set of CSR-1 target genes with conserved germline expression, enrichment in operons and more slowly evolving coding sequences than other genes, along with a small group of evolutionarily labile targets. We demonstrate that the association of CSR-1 with chromatin is preserved, and show that depletion of cbr-csr-1 leads to chromosome segregation defects and embryonic lethality. This first comparative characterization of a small RNA pathway in Caenorhabditis establishes a conserved nuclear role for CSR-1 and highlights its key role in germline gene regulation across multiple animal species. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  10. A comparative density functional study on electrical properties of layered penta-graphene

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Zhi Gen, E-mail: yuzg@ihpc.a-star.edu.sg; Zhang, Yong-Wei, E-mail: zhangyw@ihpc.a-star.edu.sg [Institute of High Performance Computing, Singapore 138632 (Singapore)

    2015-10-28

    We present a comparative study of the influence of the number of layers, the biaxial strain in the range of −3% to 3%, and the stacking misalignments on the electronic properties of a new 2D carbon allotrope, penta-graphene (PG), based on hybrid-functional method within the density functional theory (DFT). In comparison with local exchange-correlation approximation in the DFT, the hybrid-functional provides an accurate description on the degree of p{sub z} orbitals localization and bandgap. Importantly, the predicted bandgap of few-layer PG has a weak layer dependence. The bandgap of monolayer PG is 3.27 eV, approximately equal to those of GaN and ZnO; and the bandgap of few-layer PG decreases slowly with the number of layers (N) and converge to 2.57 eV when N ≥ 4. Our calculations using HSE06 functional on few-layer PG reveal that bandgap engineering by stacking misalignment can further tune the bandgap down to 1.37 eV. Importantly, there is no direct-to-indirect bandgap transition in PG by varying strain, layer number, and stacking misalignment. Owing to its tunable, robustly direct, and wide bandgap characteristics, few-layer PG is promising for optoelectronic and photovoltaic applications.

  11. Assessment of the Effects of Perineoplasty on Female Sexual Function

    Directory of Open Access Journals (Sweden)

    Cihan İnan

    2015-09-01

    Full Text Available ackground: The scar tissue formed by episiotomy during vaginal delivery, and the related pain, is very frequent. The change in the normal anatomy can cause cosmetic and physiologic problems. It can affect and cause deterioration in sexual functions. Therefore, making the right diagnosis and applying the right surgical procedures are very important. Aims: Our aim was to examine the effect of the perineoplasty operation on the sexual dysfunctions that present due to vaginal delivery. Study Design: Self-controlled study. Methods: Forty patients, who attended our clinic between April 2012 and May 2013, and who were between the ages of 20 and 50 years, were included in the study. The patients had complaints of scar tissue in the perineum and various sexual dysfunctions after vaginal delivery, and they were suitable for perineoplasty. The Female Sexual Function Index (FSFI questionnaire was applied to the patients before and 6 months after the operation, and the results were compared. Results: After the perineoplasty operation, there was a statistically significant improvement in the patients in the domains of sexual desire, arousal, lubrication, orgasm, and sexual satisfaction (p<0.005. However, there was no significant improvement in the feeling of pain during sexual intercourse (p=0.184. The mean±SD total FSFI score increased significantly after the operation (p<0.005. Conclusion: The sexual dysfunctions that develop due to perineal damage during vaginal delivery can benefit significantly from the perineoplasty operation if the indications are correct. However, vaginal perineoplasty did not provide an improvement in dyspareunia.

  12. Assessment of cognitive function in patients with myasthenia gravis

    Directory of Open Access Journals (Sweden)

    Sherifa A Hamed

    2014-12-01

    Full Text Available Aim: During the past decade, there has been an increasing interest in the evaluation of cognitive function in myasthenia gravis (MG, neuromuscular transmission disorder caused by acetylcholine receptor auto-antibodies. However, the results of previous studies on cognition and MG are inconsistent and controversial. This study aimed to evaluate cognition in patients with mild/moderate grades of MG. Methods: This study included 20 patients with MG with a mean age of 28.45 ± 8.89 years and duration of illness of 3.52 ± 1.15 years. Cognition was tested using a sensitive battery of psychometric testing (Mini-mental State Examination [MMSE], Stanford-Binet Intelligence Scale 4 th edition [SBIS] and Wechsler Memory Scale-Revised [WMS-R] and by recording P300 component of event-related potentials (ERPs, a neurophysiological analog for cognitive function. Results: Compared with healthy subjects (n = 20, patients had lower total scores of cognitive testing (MMSE, SBIS and WMS-R (P = 0.001, higher Beck Depression Inventory 2 nd edition scores (P = 0.0001 and prolonged latencies (P = 0.01 and reduced amplitudes (P = 0.001 of P300 component of ERPs. Correlations were identified between total scores of cognitive testing and age (r = -0.470, P = 0.010, duration of illness (r = -0.788, P = 0.001 and depression scores (r = -0.323, P = 0.045. Using linear regression analysis and after controlling for age and depression scores, a significant correlation was identified between total scores of cognitive testing and duration of illness (β = -0.305, P = 0.045. Conclusion: Patients with mild/moderate MG may have cognitive dysfunction. This is important to determine prognosis and managing patients.

  13. Comparing LCC with LCA to assess PSS sustainability: the case of the eco-box

    DEFF Research Database (Denmark)

    Chong, K.N.; Dreijer, L.S.; Howard, Thomas J.

    2014-01-01

    Product/Service-Systems strategies are increasingly proving to be a source of competitive advantage and environmental improvement for engineering companies, the main hypothesis being that PSS should allow to decouple functionality, user satisfaction and financial income on the one hand, from the ...... the total environmental impact of the function-delivering technology on the other. This paper describes an integration of Life Cycle Assessment (LCA) and Life Cycle Costing (LCC), in an attempt to see if the two life cycle elements are related....

  14. Multi-scale evaluation of soil functional indicators for the assessment of water and soil retention in Mediterranean semiarid landscapes

    NARCIS (Netherlands)

    Mayor, A.G.; Bautista, S.

    2012-01-01

    Ecosystem monitoring and assessment are often based on functional indicators, which provide integrated and yet simple and affordable measures of key ecosystem functions. The landscape function analysis (LFA) assesses ecosystem functioning through three indices that represent basic soil functions:

  15. Comparative life cycle assessments: The case of paper and digital media

    Energy Technology Data Exchange (ETDEWEB)

    Bull, Justin G., E-mail: jgbull@gmail.com; Kozak, Robert A., E-mail: rob.kozak@ubc.ca

    2014-02-15

    The consumption of the written word is changing, as media transitions from paper products to digital alternatives. We reviewed the life cycle assessment (LCA) research literature that compared the environmental footprint of digital and paper media. To validate the role of context in influencing LCA results, we assessed LCAs that did not compare paper and print, but focused on a product or component that is part of the Information and Communication Technology (ICT) sector. Using a framework that identifies problems in LCA conduct, we assessed whether the comparative LCAs were accurate expressions of the environmental footprints of paper and print. We hypothesized that the differences between the product systems that produce paper and digital media weaken LCA's ability to compare environmental footprints. We also hypothesized that the characteristics of ICT as an industrial sector weaken LCA as an environmental assessment methodology. We found that existing comparative LCAs offered problematic comparisons of paper and digital media for two reasons — the stark material differences between ICT products and paper products, and the unique characteristics of the ICT sector. We suggested that the context of the ICT sector, best captured by the concept of “Moore's Law”, will continuously impede the ability of the LCA methodology to measure ICT products. -- Highlights: • We review the LCA research that compares paper and digital media. • We contrast the comparative LCAs with LCAs that examine only digital products. • Stark differences between paper and digital media weakens LCA findings. • Digital products in general challenge the LCA method's reliability. • Continuous innovation and global nature of digital products impedes LCA methodology.

  16. Comparative life cycle assessments: The case of paper and digital media

    International Nuclear Information System (INIS)

    Bull, Justin G.; Kozak, Robert A.

    2014-01-01

    The consumption of the written word is changing, as media transitions from paper products to digital alternatives. We reviewed the life cycle assessment (LCA) research literature that compared the environmental footprint of digital and paper media. To validate the role of context in influencing LCA results, we assessed LCAs that did not compare paper and print, but focused on a product or component that is part of the Information and Communication Technology (ICT) sector. Using a framework that identifies problems in LCA conduct, we assessed whether the comparative LCAs were accurate expressions of the environmental footprints of paper and print. We hypothesized that the differences between the product systems that produce paper and digital media weaken LCA's ability to compare environmental footprints. We also hypothesized that the characteristics of ICT as an industrial sector weaken LCA as an environmental assessment methodology. We found that existing comparative LCAs offered problematic comparisons of paper and digital media for two reasons — the stark material differences between ICT products and paper products, and the unique characteristics of the ICT sector. We suggested that the context of the ICT sector, best captured by the concept of “Moore's Law”, will continuously impede the ability of the LCA methodology to measure ICT products. -- Highlights: • We review the LCA research that compares paper and digital media. • We contrast the comparative LCAs with LCAs that examine only digital products. • Stark differences between paper and digital media weakens LCA findings. • Digital products in general challenge the LCA method's reliability. • Continuous innovation and global nature of digital products impedes LCA methodology

  17. Longitudinal study comparing sonographic and MRI assessments of acute and healing hamstring injuries

    NARCIS (Netherlands)

    Connell, David A.; Schneider-Kolsky, Michal E.; Hoving, Jan Lucas; Malara, Frank; Buchbinder, Rachelle; Koulouris, George; Burke, Frank; Bass, Cheryl

    2004-01-01

    OBJECTIVE: We compared sonography and MRI for assessing hamstring injuries in professional football players (Australian football) 3 days, 2 weeks, and 6 weeks after an injury and identified imaging characteristics at baseline that may be useful in predicting the time needed for return to

  18. The Use of Illustrations in Large-Scale Science Assessment: A Comparative Study

    Science.gov (United States)

    Wang, Chao

    2012-01-01

    This dissertation addresses the complexity of test illustrations design across cultures. More specifically, it examines how the characteristics of illustrations used in science test items vary across content areas, assessment programs, and cultural origins. It compares a total of 416 Grade 8 illustrated items from the areas of earth science, life…

  19. Improving the Comparability and Local Usefulness of International Assessments: A Look Back and a Way Forward

    Science.gov (United States)

    Rutkowski, Leslie; Rutkowski, David

    2018-01-01

    Over time international large-scale assessments have grown in terms of number of studies, cycles, and participating countries, many of which are a heterogeneous mix of economies, languages, cultures, and geography. This heterogeneity has meaningful consequences for comparably measuring both achievement and non-achievement constructs, such as…

  20. Comparing the creativity of children's design solutions based on expert assessment

    NARCIS (Netherlands)

    Thang, B.; Sluis - Thiescheffer, R.J.W.; Bekker, M.M.; Eggen, J.H.; Vermeeren, A.P.O.S.; Ridder, de H.

    2008-01-01

    LOBBI Netherlands Consortium Subscribe (Full Service) Register (Limited Service, Free) Login Search: The ACM Digital Library The Guide Feedback Comparing the creativity of children's design solutions based on expert assessment Full text Pdf (3.04 MB) Source Interaction Design and Children archive

  1. A Comparative Assessment of Knowledge Management Leadership Approaches within the Department of Defense

    Science.gov (United States)

    2007-03-01

    A COMPARATIVE ASSESSMENT OF KNOWLEDGE MANAGEMENT LEADERSHIP APPROACHES WITHIN THE DEPARTMENT OF DEFENSE... MANAGEMENT LEADERSHIP APPROACHES WITHIN THE DEPARTMENT OF DEFENSE THESIS Presented to the Faculty Department of Systems and Engineering...KNOWLEDGE MANAGEMENT LEADERSHIP APPROACHES WITHIN THE DEPARTMENT OF DEFENSE Tommy V. S. Marshall II, BS Captain, USAF Approved

  2. Overview, comparative assessment and recommendations of forecasting models for short-term water demand prediction

    CSIR Research Space (South Africa)

    Anele, AO

    2017-11-01

    Full Text Available -term water demand (STWD) forecasts. In view of this, an overview of forecasting methods for STWD prediction is presented. Based on that, a comparative assessment of the performance of alternative forecasting models from the different methods is studied. Times...

  3. A Qualitative Assessment of the Learning Outcomes of Teaching Introductory American Politics in Comparative Perspective

    Science.gov (United States)

    Gelbman, Shamira M.

    2011-01-01

    This article discusses the findings of an ethnographic content analysis of students' written reflections as a means for assessing the learning outcomes of teaching introductory American politics in comparative perspective. It focuses especially on determining whether and how this approach enhanced students' understanding and retention of knowledge…

  4. Small Business Contracting in the United States and Europe: A Comparative Assessment

    Science.gov (United States)

    2010-03-01

    unlimited. Prepared for: Naval Postgraduate School, Monterey, California 93943 SMALL BUSINESS CONTRACTING IN THE UNITED STATES AND EUROPE: A...COMPARATIVE ASSESSMENT by Max Kidalov, Assistant Professor Procurement Law & Policy March 2010 Graduate School of Business & Public Policy...Daniel T. Oliver Leonard A. Ferrari President Executive Vice President and Provost The report entitled “Small Business Contracting in

  5. Comparing the organisational structure of the preoperative assessment clinic at eight university hospitals

    NARCIS (Netherlands)

    Edward, G. M.; Biervliet, J. D.; Hollmann, M. W.; Schlack, W. S.; Preckel, B.

    2008-01-01

    The preoperative assessment clinic (PAC) has been implemented in most major hospitals. However, there is no uniformity in the way PACs are organised. We compared the organisational structure of the PACs from all eight university hospitals in The Netherlands, looking at the following variables:

  6. Comparative data from young men and women on masseter muscle fibres, function and facial morphology

    DEFF Research Database (Denmark)

    Tuxen, A.; Bakke, M.; Pinholt, E. M.

    1999-01-01

    The primary aim was to relate information about masseter muscle fibres and function to aspects of facial morphology in a group of healthy young men. The secondary aim was to investigate possible sex differences using data previously obtained from a comparable group of age-matched, healthy women......, and the tissue examined for myosin ATPase activity. Further, the cross-sectional areas of the different fibre types were measured. In spite of using age-matched healthy men and women with a full complement of teeth, statistically significant sex differences were found among measures related to muscle function...... and some measures of facial morphology. Thus data from men and women should not be pooled uncritically. The greater bite force in men than women corresponded with the greater diameter and cross-sectional area of type II fibres. Further, the males had more anteriorly inclined mandibles and shorter anterior...

  7. Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo.

    Science.gov (United States)

    Belch, Jill J F; Akbar, Naveed; Alapati, Venkateswara; Petrie, John; Arthur, Simon; Khan, Faisel

    2013-01-01

    Endothelial dysfunction is associated with early development of cardiovascular disease, making longitudinal measurements desirable. We devised a protocol using laser Doppler imaging (LDI) and iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) to assess the skin microcirculation longitudinally in mice every 4 weeks for 24 weeks in two groups of C57BL/6 mice, chow versus high-cholesterol diet(known to induce endothelial dysfunction). LDI measurements were compared with vascular function (isometric tension) measured using wire myography in the tail artery in response to ACh and SNP. Microvascular responses to ACh were significantly reduced in cholesterol-fed versus chow-fed mice from week 4 onwards (Phydrochloride (L-NAME) showed a significant reduction in ACh response compared with vehicle-treated animals (P<0.05) at baseline and at 12 weeks. In cholesterol-fed mice, ACh responses were 226 ± 21 and 180 ± 21 AU (P=0.03) before and after L-NAME, respectively. A reduction in ex-vivo ACh response was detected in the tail artery in cholesterol-fed mice, and a significant correlation found between peak microvascular ACh response and maximum ACh response in the tail artery (r=0.699, P=0.017). No changes were found in SNP responses in the microvasculature or tail artery. Using this protocol, we have shown longitudinal decreases in microvascular endothelial function to cholesterol feeding. L-NAME studies confirm that the reduced vasodilatation to ACh in cholesterol-fed mice was mediated partly through reduced NO bioavailability. Wire myography of tail arteries confirmed that in-vivo measurements of microvascular function reflect ex-vivo vascular function in other beds. Longitudinal assessments of skin microvascular function in mice could provide a useful translatable model for assessing early endothelial dysfunction. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. A Study of the Social Effects in a Comparative Assessment among the Electricity Generating Systems

    International Nuclear Information System (INIS)

    Kim, Kil Yoo; Kim, Tae Woon

    2007-01-01

    A comparative assessment among 7 electricity generating systems by considering their environmental impacts, risks, health effects, and social effects was studied last year. The compared electricity generating systems are nuclear, coal, LNG, hydro, oil, wind, photovoltaic (=solar) ones. In last year's work, the social effects were handled by a public acceptance based on an aversion. However, in this paper, the social effects were also studied by a preference in view of the 'willingness to pay' (WTP). With the new social effects study, a comparative analysis of the 7 electricity generation systems was performed in this paper

  9. Comparative assessment of nuclear power and other energy sources: the DECADES project

    International Nuclear Information System (INIS)

    Bennett, L.L.

    1996-01-01

    The environmental and health related impacts of different energy systems are emerging as significant issues. To promote international cooperation in this field, the inter-agency project on databases and methodologies for comparative assessment of different energy sources for electricity generation, called DECADES, was established at the end of 1992. In October 1995 was held the International Symposium on ''Electricity, Health and the Environment - Comparative Assessment in Support of Decision Making''. Through its programs and activities, the IAEA plays a leading role, in cooperation with other organizations, in the DECADES project, to examine areas in which international expertise and support can best be applied to assist national policy and decision makers in objectively and comprehensively assessing their energy systems and strategies

  10. Sustainable energy provision: a comparative assessment of the various electricity supply options

    International Nuclear Information System (INIS)

    Voss, A.

    2000-01-01

    The provision of electricity is of central importance for economic growth and societal development. While numerous societal and economic benefits arise from the use of electricity, the production of electricity can also have negative impacts on the environment and the climate system. The commitment to sustainable development calls for the evaluation of the extent to which the different electricity supply options fulfill the sustainability criteria. The conceptual framework of Life Cycle Assessment (LCA) can provide a solid basis for a comparative assessment of different electricity supply options with regard to their environmental impacts, raw material requirements as well as their resulting external costs. Results of a comprehensive comparative assessment of nuclear energy and other electricity options are presented. (author)

  11. Assessment of tropospheric delay mapping function models in Egypt: Using PTD database model

    Science.gov (United States)

    Abdelfatah, M. A.; Mousa, Ashraf E.; El-Fiky, Gamal S.

    2018-06-01

    For space geodetic measurements, estimates of tropospheric delays are highly correlated with site coordinates and receiver clock biases. Thus, it is important to use the most accurate models for the tropospheric delay to reduce errors in the estimates of the other parameters. Both the zenith delay value and mapping function should be assigned correctly to reduce such errors. Several mapping function models can treat the troposphere slant delay. The recent models were not evaluated for the Egyptian local climate conditions. An assessment of these models is needed to choose the most suitable one. The goal of this paper is to test the quality of global mapping function which provides high consistency with precise troposphere delay (PTD) mapping functions. The PTD model is derived from radiosonde data using ray tracing, which consider in this paper as true value. The PTD mapping functions were compared, with three recent total mapping functions model and another three separate dry and wet mapping function model. The results of the research indicate that models are very close up to zenith angle 80°. Saastamoinen and 1/cos z model are behind accuracy. Niell model is better than VMF model. The model of Black and Eisner is a good model. The results also indicate that the geometric range error has insignificant effect on slant delay and the fluctuation of azimuth anti-symmetric is about 1%.

  12. Age-related normal structural and functional ventricular values in cardiac function assessed by magnetic resonance

    International Nuclear Information System (INIS)

    Fiechter, Michael; Gaemperli, Oliver; Kaufmann, Philipp A; Fuchs, Tobias A; Gebhard, Catherine; Stehli, Julia; Klaeser, Bernd; Stähli, Barbara E; Manka, Robert; Manes, Costantina; Tanner, Felix C

    2013-01-01

    The heart is subject to structural and functional changes with advancing age. However, the magnitude of cardiac age-dependent transformation has not been conclusively elucidated. This retrospective cardiac magnetic resonance (CMR) study included 183 subjects with normal structural and functional ventricular values. End systolic volume (ESV), end diastolic volume (EDV), and ejection fraction (EF) were obtained from the left and the right ventricle in breath-hold cine CMR. Patients were classified into four age groups (20–29, 30–49, 50–69, and ≥70 years) and cardiac measurements were compared using Pearson’s rank correlation over the four different groups. With advanced age a slight but significant decrease in ESV (r=−0.41 for both ventricles, P<0.001) and EDV (r=−0.39 for left ventricle, r=−0.35 for right ventricle, P<0.001) were observed associated with a significant increase in left (r=0.28, P<0.001) and right (r=0.27, P<0.01) ventricular EF reaching a maximal increase in EF of +8.4% (P<0.001) for the left and +6.1% (P<0.01) for the right ventricle in the oldest compared to the youngest patient group. Left ventricular myocardial mass significantly decreased over the four different age groups (P<0.05). The aging process is associated with significant changes in left and right ventricular EF, ESV and EDV in subjects with no cardiac functional and structural abnormalities. These findings underline the importance of using age adapted values as standard of reference when evaluating CMR studies

  13. Comparative assessment of nuclear power and other options: the DECADES project

    International Nuclear Information System (INIS)

    Vladu, I. F.

    1996-01-01

    This paper presents the results obtained in constructing and implementing a general framework for performing comprehensive assessment within the inter-agency joint project on Databases and Methodologies for Comparative Assessment of Different Energy Sources for electricity generation. The project was established in 1992 by nine international organizations. A short description of the DECADES project objectives, structure and main components is given. The technology inventory databases, which are a major part of the project, address all the levels of different energy chains, from fuel extraction through electricity generation to waste disposal. These databases support comparative assessment in the power sector, by providing generic information as well as country or region specific information on existing technologies and on those expected to enter the market in the next two to three decades. The paper further touches on the types of assessment that can be carried out using the methodology and databases developed. It point out in this regard the possibilities and limitations of comparative assessments performed at the level of power plant, full electricity supply chain and country or region electricity generation system. Illustrative results are presented for comparisons performed at all these levels. Case studies and workshops and seminars are one of the main activities carried out until now for validation and dissemination of the DECADES Computer Tools. In those studies where it was considered, nuclear power appeared to be cost effective for reducing emissions of CO 2 , SO 2 , NO x and other greenhouse gases. Finally, the paper briefly introduce the activities envisaged for the phase II of the DECADES project which will focus on disseminating the current computer tools, providing training in the use of the tools, and supporting country studies, and on development of new analytical capabilities. The paper concludes with some findings and remarks pointing out the

  14. The outcome of conservative treatment of adult distal radius fractures compared with the other wrist: radiological and functional evaluation

    Directory of Open Access Journals (Sweden)

    Mustafa Uslu

    2014-09-01

    Full Text Available Objective: This study was designed to evaluate anatomical and functional results of closed reduction-long arm cast treatment for distal radius fractures and compared other healthy wrist in the adults. Methods: 77 patients with distal radius fracture were treated conservatively between January 2010 and December 2010. The fractures were classified according to AO and Frykman classification system and investigated prospectively. The radiological and anatomical results were assessed by the Stewart score criteria. The functional results were assessed by Quick-Disability of Arm, Shoulder and Hand questionnaire (Q-DASH and the Stewart II score criteria. The mean follow-up of patients was 12 months. Results: The forty patients had right wrist fractured, 37 patients had left wrist fractured. According to Frykman classification 46 patients were type I-II fractured, according to AO classification 59 patients were type 23,A2,1 and 23,A2,2 fractured. According to Stewart the radiological and anatomical, the result were excellent in 57, good in 17, fair in 3. According to Stewart II functional criteria, the results were assessed excellent in 57, good in 8, fair in 12 The mean Q-DASH score was 6,37. The overall complication rate was 12.98%. Mild Carpal tunnel syndrome was observed in the two patients, ulna styloid nonunion in the four patients, pain of distal radioulnar joint in the one patient, mild carpal tunnel syndrome and tenderness of distal radioulnar joint in the three patients. Conclusion: Closed reduction and cast immobilization is still an effective and inexpensive treatment method in distal radial fractures. J Clin Exp Invest 2014; 5 (3: 403-409

  15. Outcome assessment of lingual and labial appliances compared with cephalometric analysis, peer assessment rating, and objective grading system in Angle Class II extraction cases.

    Science.gov (United States)

    Deguchi, Toru; Terao, Fumie; Aonuma, Tomo; Kataoka, Tomoki; Sugawara, Yasuyo; Yamashiro, Takashi; Takano-Yamamoto, Teruko

    2015-05-01

    To validate our hypothesis that there would be significant differences in treatment outcomes, including cephalometric values, degree of root resorption, occlusal indices, and functional aspect, between cases treated with labial and lingual appliances. Twenty-four consecutively treated Class II cases with extractions and lingual appliance were compared with 25 matched cases treated with extraction and labial appliance. Orthodontic treatment outcomes were evaluated by cephalometric analysis, peer assessment rating, and an objective grading system (OGS). Additionally, functional analysis was also performed in both groups after orthodontic treatment. Statistical comparison was performed using the Wilcoxon signed rank test within the groups, and the Mann-Whitney U-test was used to compare between the labial and lingual groups. The only significant difference between the groups was that the interincisal angle was larger in the lingual group than in the labial group. OGS evaluation showed that control over root angulation was significantly worse in the lingual group than in the labial group. There was no significant difference between groups in the amount of root resorption or in functional evaluation. Generally, lingual appliances offer comparable treatment results to those obtained with labial appliances. However, care should be taken with lingual appliances because they are more prone to produce uprighted incisors and root angulation.

  16. Assessment of Global Functioning in Adolescents with Autism Spectrum Disorders: Utility of the Developmental Disability-Child Global Assessment Scale

    Science.gov (United States)

    White, Susan W.; Smith, Laura A.; Schry, Amie R.

    2014-01-01

    Assessment of global functioning is an important consideration in treatment outcome research; yet, there is little guidance on its evidence-based assessment for children with autism spectrum disorders. This study investigated the utility and validity of clinician-rated global functioning using the Developmental Disability-Child Global Assessment…

  17. Contemporary Assessment of Left Ventricular Diastolic Function in Older Adults

    DEFF Research Database (Denmark)

    Shah, Amil M.; Claggett, Brian; Kitzman, Dalane

    2017-01-01

    Background: Although age-Associated changes in left ventricular diastolic function are well recognized, limited data exist characterizing measures of diastolic function in older adults, including both reference ranges reflecting the older adult population and prognostically relevant values...

  18. Lawrence Livermore National Security CFO Processes Functional Management Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Sparks, A; Sampson, D; Thomas, B; Mendez, M

    2008-06-12

    The scope of the Functional Management Assessment of the CFO included a review of the CFO Organizational Structure, including deployed financial services and the division of responsibilities and internal controls between CFO and other organizations that perform financial functions across the Laboratory. In addition, the assessment team solicited input from end users and reviewers. Three issues discussed are: ISSUE 1: Financial activities and cash transactions are occurring outside the CFO organization. Approximately $200M of non-purchase order spending occurs in seven areas outside CFO control (travel, relocation, special disbursements, IPO, legal, risk management, and freight). NIF financial services have not been integrated into the CFO organization and operate outside CFO control. Business risks--There is no single point of financial accountably; Currently within the CFO and Business and Operations organizations there is a lack of clarity of roles and responsibilities for financial activities; Financial talent within the laboratory is fragmented; and Inefficiencies exist based on the current structure; An example of the above business risks associated with organizational structure can be observed in the process for reimbursement of relocation costs to employees. Currently, Human Resources and Travel both administer portions of an employee's relocation. Costs are reviewed for compliance with FAR travel guidelines and for compliance with the offer letter but there is no financial review for allowability of costs nor is there a single point where the total relocation costs are reviewed. Through the e-pay system the check is processed by the CFO organization but there is no review by that organization. ISSUE 2: Impact of involuntary separation on current and future activities. 3 risks are: (1) Loss of internal controls--with the upcoming involuntary reductions there will be a loss of personnel with institutional knowledge which will increase the risk of losing

  19. Better assessment of physical function: item improvement is neglected but essential.

    Science.gov (United States)

    Bruce, Bonnie; Fries, James F; Ambrosini, Debbie; Lingala, Bharathi; Gandek, Barbara; Rose, Matthias; Ware, John E

    2009-01-01

    Physical function is a key component of patient-reported outcome (PRO) assessment in rheumatology. Modern psychometric methods, such as Item Response Theory (IRT) and Computerized Adaptive Testing, can materially improve measurement precision at the item level. We present the qualitative and quantitative item-evaluation process for developing the Patient Reported Outcomes Measurement Information System (PROMIS) Physical Function item bank. The process was stepwise: we searched extensively to identify extant Physical Function items and then classified and selectively reduced the item pool. We evaluated retained items for content, clarity, relevance and comprehension, reading level, and translation ease by experts and patient surveys, focus groups, and cognitive interviews. We then assessed items by using classic test theory and IRT, used confirmatory factor analyses to estimate item parameters, and graded response modeling for parameter estimation. We retained the 20 Legacy (original) Health Assessment Questionnaire Disability Index (HAQ-DI) and the 10 SF-36's PF-10 items for comparison. Subjects were from rheumatoid arthritis, osteoarthritis, and healthy aging cohorts (n = 1,100) and a national Internet sample of 21,133 subjects. We identified 1,860 items. After qualitative and quantitative evaluation, 124 newly developed PROMIS items composed the PROMIS item bank, which included revised Legacy items with good fit that met IRT model assumptions. Results showed that the clearest and best-understood items were simple, in the present tense, and straightforward. Basic tasks (like dressing) were more relevant and important versus complex ones (like dancing). Revised HAQ-DI and PF-10 items with five response options had higher item-information content than did comparable original Legacy items with fewer response options. IRT analyses showed that the Physical Function domain satisfied general criteria for unidimensionality with one-, two-, three-, and four-factor models

  20. Assessment of platelet function in healthy sedated cats using three whole blood platelet function tests.

    Science.gov (United States)

    Ho, Kimberly K; Abrams-Ogg, Anthony C G; Wood, R Darren; O'Sullivan, M Lynne; Kirby, Gordon M; Blois, Shauna L

    2015-05-01

    The objectives of this study were to establish feline references intervals for 3 commercial whole blood platelet function test analyzer systems: Multiplate analyzer (MP; Roche Diagnostics International Ltd., Rotkreuz, Switzerland), Platelet Function Analyzer-100 (PF: Siemens Canada, Mississauga, Ontario, Canada), and Plateletworks Combo-25 kit (PW; Helena Laboratories, Beaumont, TX). Venipuncture was performed on 55 healthy sedated cats, and platelet aggregation in response to adenosine diphosphate (ADP), collagen (COL), and arachidonic acid (AA; MP only) was assessed using citrated blood. For the MP analyzer, median (95% confidence intervals [CIs]) area under curve (Units) for ADP, COL, and AA agonists were 87 (11-176), 81 (32-129), and 91 (59-129), respectively. For the PF analyzer, median (95% CIs) closure time, using COL-ADP cartridges, was 69 (46-89) sec. For the PW assay, median (95% CIs) percent aggregations for ADP and COL agonists were 71 (18-92) and 49 (9-96), respectively, using impedance hematology analyzer platelet counts, and 94 (25-98) and 68 (14-119), respectively, using flow cytometry hematology analyzer platelet counts. There were low correlations between the PF analyzer (COL-ADP cartridge) and MP analyzer (COL agonist; ρ = 0.11), and between the PF analyzer (COL-ADP cartridge) and PW assay (COL agonist using impedance platelet counts; ρ = 0.14). The PW assay percent aggregations using impedance and flow cytometric platelet counts were correlated for both ADP (ρ = 0.64) and COL (ρ = 0.64) agonists. Platelet function testing using these tests are feasible in cats, but 95% CIs are wide, so single results may be difficult to interpret. Platelet counting by impedance or flow cytometry may be used for the PW assay but are not interchangeable. © 2015 The Author(s).

  1. Assessing functional mobility in survivors of lower-extremity sarcoma: reliability and validity of a new assessment tool.

    Science.gov (United States)

    Marchese, Victoria G; Rai, Shesh N; Carlson, Claire A; Hinds, Pamela S; Spearing, Elena M; Zhang, Lijun; Callaway, Lulie; Neel, Michael D; Rao, Bhaskar N; Ginsberg, Jill P

    2007-08-01

    Reliability and validity of a new tool, Functional Mobility Assessment (FMA), were examined in patients with lower-extremity sarcoma. FMA requires the patients to physically perform the functional mobility measures, unlike patient self-report or clinician administered measures. A sample of 114 subjects participated, 20 healthy volunteers and 94 patients with lower-extremity sarcoma after amputation, limb-sparing, or rotationplasty surgery. Reliability of the FMA was examined by three raters testing 20 healthy volunteers and 23 subjects with lower-extremity sarcoma. Concurrent validity was examined using data from 94 subjects with lower-extremity sarcoma who completed the FMA, Musculoskeletal Tumor Society (MSTS), Short-Form 36 (SF-36v2), and Toronto Extremity Salvage Scale (TESS) scores. Construct validity was measured by the ability of the FMA to discriminate between subjects with and without functional mobility deficits. FMA demonstrated excellent reliability (ICC [2,1] >or=0.97). Moderate correlations were found between FMA and SF-36v2 (r = 0.60, P < 0.01), FMA and MSTS (r = 0.68, P < 0.01), and FMA and TESS (r = 0.62, P < 0.01). The patients with lower-extremity sarcoma scored lower on the FMA as compared to healthy controls (P < 0.01). The FMA is a reliable and valid functional outcome measure for patients with lower-extremity sarcoma. This study supports the ability of the FMA to discriminate between patients with varying functional abilities and supports the need to include measures of objective functional mobility in examination of patients with lower-extremity sarcoma.

  2. Estimation Methods of the Point Spread Function Axial Position: A Comparative Computational Study

    Directory of Open Access Journals (Sweden)

    Javier Eduardo Diaz Zamboni

    2017-01-01

    Full Text Available The precise knowledge of the point spread function is central for any imaging system characterization. In fluorescence microscopy, point spread function (PSF determination has become a common and obligatory task for each new experimental device, mainly due to its strong dependence on acquisition conditions. During the last decade, algorithms have been developed for the precise calculation of the PSF, which fit model parameters that describe image formation on the microscope to experimental data. In order to contribute to this subject, a comparative study of three parameter estimation methods is reported, namely: I-divergence minimization (MIDIV, maximum likelihood (ML and non-linear least square (LSQR. They were applied to the estimation of the point source position on the optical axis, using a physical model. Methods’ performance was evaluated under different conditions and noise levels using synthetic images and considering success percentage, iteration number, computation time, accuracy and precision. The main results showed that the axial position estimation requires a high SNR to achieve an acceptable success level and higher still to be close to the estimation error lower bound. ML achieved a higher success percentage at lower SNR compared to MIDIV and LSQR with an intrinsic noise source. Only the ML and MIDIV methods achieved the error lower bound, but only with data belonging to the optical axis and high SNR. Extrinsic noise sources worsened the success percentage, but no difference was found between noise sources for the same method for all methods studied.

  3. Comparing Sexual Function and Quality of Life in Polycystic Ovary Syndrome and Healthy Women

    Directory of Open Access Journals (Sweden)

    Vida Shafti

    2016-08-01

    Full Text Available Objective: Polycystic ovary syndrome (PCOS is one of the most common endocrine disorders that is associated with different metabolic, reproductive and psychological consequences. The main aim of this study was to compare the sexual function and quality of life in women with polycystic ovary syndrome and healthy women.Materials and methods: This is a causal-comparative study in which 129 women with polycystic ovary syndrome were qualified as the research group. The control group consisted of 125 healthy women. The sampling method was convenient and was done using Rotterdam criteria. Women of both research and control groups responded to the FSFI and WHOQOL-BREF questionnaires. Data were analyzed with SPSS software using MANOVA.Results: According to findings, all of quality of life subscales except environment domain were significantly lower in research group than healthy group (p < 0.01, but none of sexual function subscales were significantly different between two groups (p > 0.05.Conclusion: Women with PCOS in term of some quality of life parameters have lower performance than healthy women. Therefore, it seems to be essential to increase awareness about symptoms and psychological consequences and referring process in order to take advantage of the advisory services. 

  4. Comparative expression profiling reveals gene functions in female meiosis and gametophyte development in Arabidopsis.

    Science.gov (United States)

    Zhao, Lihua; He, Jiangman; Cai, Hanyang; Lin, Haiyan; Li, Yanqiang; Liu, Renyi; Yang, Zhenbiao; Qin, Yuan

    2014-11-01

    Megasporogenesis is essential for female fertility, and requires the accomplishment of meiosis and the formation of functional megaspores. The inaccessibility and low abundance of female meiocytes make it particularly difficult to elucidate the molecular basis underlying megasporogenesis. We used high-throughput tag-sequencing analysis to identify genes expressed in female meiocytes (FMs) by comparing gene expression profiles from wild-type ovules undergoing megasporogenesis with those from the spl mutant ovules, which lack megasporogenesis. A total of 862 genes were identified as FMs, with levels that are consistently reduced in spl ovules in two biological replicates. Fluorescence-assisted cell sorting followed by RNA-seq analysis of DMC1:GFP-labeled female meiocytes confirmed that 90% of the FMs are indeed detected in the female meiocyte protoplast profiling. We performed reverse genetic analysis of 120 candidate genes and identified four FM genes with a function in female meiosis progression in Arabidopsis. We further revealed that KLU, a putative cytochrome P450 monooxygenase, is involved in chromosome pairing during female meiosis, most likely by affecting the normal expression pattern of DMC1 in ovules during female meiosis. Our studies provide valuable information for functional genomic analyses of plant germline development as well as insights into meiosis. © 2014 The Authors The Plant Journal © 2014 John Wiley & Sons Ltd.

  5. On the specificity of face cognition compared with general cognitive functioning across adult age.

    Science.gov (United States)

    Hildebrandt, Andrea; Wilhelm, Oliver; Schmiedek, Florian; Herzmann, Grit; Sommer, Werner

    2011-09-01

    Face cognition is considered a specific human ability, clearly differentiable from general cognitive functioning. Its specificity is primarily supported by cognitive-experimental and neuroimaging research, but recently also from an individual differences perspective. However, no comprehensive behavioral data are available, which would allow estimating lifespan changes of the covariance structure of face-cognition abilities and general cognitive functioning as well as age-differences in face cognition after accounting for interindividual variability in general cognition. The present study aimed to fill this gap. In an age-heterogeneous (18-82 years) sample of 448 adults, we found no factorial dedifferentiation between face cognition and general cognition. Age-related differences in face memory were still salient after taking into account changes in general cognitive functioning. Face cognition thus remains a specific human ability compared with general cognition, even until old age. We discuss implications for models of cognitive aging and suggest that it is necessary to include more explicitly special social abilities in those models.

  6. Comparative assessment of spent nuclear fuel transportation routes using risk factors and a geographic information system

    International Nuclear Information System (INIS)

    Toth, D.M.

    1996-01-01

    The assessment of potential alternative routes was simplified through the use of six comparative risk factors evaluated using detailed, route-specific data. The route and environmental attributes varied strongly with location and were developed from national, state, and local sources. The six comparative factors were risk measures of incident-free transportation radiation exposure, radiological accident population exposure, nonradiological accidents, contamination of environmental sensitive areas, environmental justice for minority populations, and environmental justice for low-income populations. An assessment of four real North-Central Florida routes provided a sample implementation of the analysis tools and risk factors. The assessment routes, consisting of common beginning and end locations, included an interstate highway, a rural highway, a mostly urban highway, and a combination interstate highway with rural bypass. This route comparative assessment study predicted that the interstate highway, despite a higher population density, greater traffic volume, and greater number of vehicular fatality accidents, would present the lowest cumulative risk. On the contrary, the rural highway route, characterized as having the lowest population density, minimal vehicle traffic volume, and the lowest percentages of minority and low-income populations, displayed the highest cumulative risk measure. Factors contributing to the high risk for the rural highway route included greater route length, higher vehicular fatality accident rates per vehicle mile traveled, and the close proximity to environmentally sensitive areas. This route comparative assessment study predicted that the interstate highway, despite a higher population density, greater traffic volume, and greater number of vehicular fatality accidents, would present the lowest cumulative risk. On the contrary, the rural highway route, characterized as having the lowest population density, minimal vehicle traffic volume

  7. In multiple situational light settings, visual observation for skin colour assessment is comparable with colorimeter measurement.

    Science.gov (United States)

    Wright, C Y; Wilkes, M; du Plessis, J L; Reeder, A I; Albers, P N

    2016-08-01

    Finding inexpensive and reliable techniques for assessing skin colour is important, given that it is related to several adverse human health outcomes. Visual observation is considered a subjective approach assessment and, even when made by trained assessor, concern has been raised about the need for controlled lighting in the study venue. The aim of this study is to determine whether visual skin colour assessments correlate with objective skin colour measurements in study venues with different lighting types and configurations. Two trained investigators, with confirmed visual acuity, visually classified the inner, upper arm skin colour of 556 adults using Munsell(®) colour classifications converted to Individual Typology Angle (°ITA) values based on published data. Skin colour at the same anatomic site was also measured using a colorimeter. Each participant was assessed in one of 10 different buildings, each with a different study day. Munsell(®) -derived °ITA values were compared to colorimeter °ITA values for the full sample and by building/day. We found a strong positive, monotonic correlation between Munsell(®) derived °ITA values and colorimeter °ITA values for all participants (Spearman ρ = 0.8585, P colorimeter °ITA values were compared for participants assessed in the same building for all 10 buildings (Spearman ρ values ranged from 0.797 to 0.934, all correlations were statistically significant at P < 0.001). It is possible to visually assess individual skin colour in multiple situational lighting settings and retrieve results that are comparable with objective measurements of skin colour. This was true for individuals of varying population groups and skin pigmentation. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. Prospective study comparing laparoscopic and open adenomectomy: Surgical and functional results.

    Science.gov (United States)

    Garcia-Segui, A; Angulo, J C

    Open adenomectomy (OA) is the surgery of choice for large volume benign prostatic hyperplasia, and laparoscopic adenomectomy (LA) represents a minimally invasive alternative. We present a long-term, prospective study comparing both techniques. The study consecutively included 199 patients with benign prostatic hyperplasia and prostate volumes>80g who were followed for more than 12 months. The patients underwent OA (n=97) or LA (n=102). We recorded and compared demographic and perioperative data, functional results and complications using a descriptive statistical analysis. The mean age was 69.2±7.7 years (range 42-87), and the mean prostate volume (measured by TRUS) was 112.1±32.7mL (range 78-260). There were no baseline differences among the groups in terms of age, ASA scale, prostate volume, PSA levels, Qmax, IPSS, QoL or treatments prior to the surgery. The surgical time (P<.0001) and catheter time (P<.0002) were longer in the LA group. Operative bleeding (P<.0001), transfusion rate (P=.0015) and mean stay (P<.0001) were significantly lower in the LA group. The LA group had a lower rate of complications (P=.04), but there were no significant differences between the groups in terms of major complications (Clavien score≥3) (P=.13) or in the rate of late complications (at one year) (P=.66). There were also no differences between the groups in the functional postoperative results: IPSS (P=.17), QoL (P=.3) and Qmax (P=.17). LA is a reasonable, safe and effective alternative that results in less bleeding, fewer transfusions, shorter hospital stays and lower morbidity than OA. LA has similar functional results to OA, at the expense of longer surgical times and longer catheter times. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  9. A comparative risk assessment for Listeria monocytogenes in prepackaged versus retail-sliced deli meat.

    Science.gov (United States)

    Endrikat, Sarah; Gallagher, Daniel; Pouillot, Régis; Hicks Quesenberry, Heather; Labarre, David; Schroeder, Carl M; Kause, Janell

    2010-04-01

    Deli meat was ranked as the highest-risk ready-to-eat food vehicle of Listeria monocytogenes within the 2003 U.S. Food and Drug Administration and U.S. Department of Agriculture, Food Safety and Inspection Service risk assessment. The comparative risk of L. monocytogenes in retail-sliced versus prepackaged deli meats was evaluated with a modified version of this model. Other research has found that retail-sliced deli meats have both higher prevalence and levels of L. monocytogenes than have product sliced and packaged at the manufacturer level. The updated risk assessment model considered slicing location as well as the use of growth inhibitors. The per annum comparative risk ratio for the number of deaths from retail-sliced versus prepackaged deli meats was found to be 4.89, and the per-serving comparative risk ratio was 4.27. There was a significant interaction between the use of growth inhibitors and slicing location. Almost 70% of the estimated deaths occurred from retail-sliced product that did not possess a growth inhibitor. A sensitivity analysis, assessing the effect of the model's consumer storage time and shelf life assumptions, found that even if retail-sliced deli meats were stored for a quarter of the time prepackaged deli meats were stored, retail-sliced product is 1.7 times more likely to result in death from listeriosis. Sensitivity analysis also showed that the shelf life assumption had little effect on the comparative risk ratio.

  10. Comparative life cycle assessment (LCA) of biodiesel and fossil diesel fuel

    International Nuclear Information System (INIS)

    Spirinckx, C.; Xeuterick, D.

    1997-01-01

    Complementary to VlTO's demonstration project on the use of biodiesel as engine fuel (including on the road emission measurements) in Flanders, Belgium, a comparative life cycle assessment (LCA) has been carried out for rapeseed methyl ester (RME) and fossil diesel fuel. The primary concern of this study is the question as to whether or not the production of biodiesel is comparable to the production of fossil diesel fuel from an environmental point of view, taking into account all stages of the life cycle of these two products. The study covers: (1) a description of the LCA methodology used; (2) a definition of the goal and scope of the study: (3) an inventory of the consumption of energy and materials and the discharges to the environment, from the cradle to the grave, for both alternative fuels: (4) a comparative impact assessment; and (5) the interpretation of the results. The results of this comparative LCA can be used in the final decision making process next to the results of a social and economical assessment. 6 refs

  11. Comparative Analysis of Fuzzy Set Defuzzification Methods in the Context of Ecological Risk Assessment

    Directory of Open Access Journals (Sweden)

    Užga-Rebrovs Oļegs

    2017-12-01

    Full Text Available Fuzzy inference systems are widely used in various areas of human activity. Their most widespread use lies in the field of fuzzy control of technical devices of different kind. Another direction of using fuzzy inference systems is modelling and assessment of different kind of risks under insufficient or missing objective initial data. Fuzzy inference is concluded by the procedure of defuzzification of the resulting fuzzy sets. A large number of techniques for implementing the defuzzification procedure are available nowadays. The paper presents a comparative analysis of some widespread methods of fuzzy set defuzzification, and proposes the most appropriate methods in the context of ecological risk assessment.

  12. Comparative assessment of EIA systems in MENA countries: challenges and prospects

    International Nuclear Information System (INIS)

    El-Fadl, Karma; El-Fadel, Mutasem

    2004-01-01

    Environmental impact assessment (EIA) was devised as a decision tool in response to the grand swell of ecocentric concerns to mediate between the technocentric view of continued development and the ability to create economic growth while overcoming environmental problems. The assimilation of the philosophy and practice of EIA into a broad range of cultures and political systems reflects the desire and need to integrate environmental considerations into the decision-making process. This paper unveils the status of EIA systems in countries of the Middle East and North Africa region through a comparative assessment of existing and planned legislation and procedures

  13. Testing the basic assumption of the hydrogeomorphic approach to assessing wetland functions.

    Science.gov (United States)

    Hruby, T

    2001-05-01

    The hydrogeomorphic (HGM) approach for developing "rapid" wetland function assessment methods stipulates that the variables used are to be scaled based on data collected at sites judged to be the best at performing the wetland functions (reference standard sites). A critical step in the process is to choose the least altered wetlands in a hydrogeomorphic subclass to use as a reference standard against which other wetlands are compared. The basic assumption made in this approach is that wetlands judged to have had the least human impact have the highest level of sustainable performance for all functions. The levels at which functions are performed in these least altered wetlands are assumed to be "characteristic" for the subclass and "sustainable." Results from data collected in wetlands in the lowlands of western Washington suggest that the assumption may not be appropriate for this region. Teams developing methods for assessing wetland functions did not find that the least altered wetlands in a subclass had a range of performance levels that could be identified as "characteristic" or "sustainable." Forty-four wetlands in four hydrogeomorphic subclasses (two depressional subclasses and two riverine subclasses) were rated by teams of experts on the severity of their human alterations and on the level of performance of 15 wetland functions. An ordinal scale of 1-5 was used to quantify alterations in water regime, soils, vegetation, buffers, and contributing basin. Performance of functions was judged on an ordinal scale of 1-7. Relatively unaltered wetlands were judged to perform individual functions at levels that spanned all of the seven possible ratings in all four subclasses. The basic assumption of the HGM approach, that the least altered wetlands represent "characteristic" and "sustainable" levels of functioning that are different from those found in altered wetlands, was not confirmed. Although the intent of the HGM approach is to use level of functioning as a

  14. The OTOLITH Experiment - Assessment of Otolith Function During Postflight Re-adaption

    Science.gov (United States)

    Clarke, A. H.; Wood, S. J.; Schoenfeld, U.

    2010-01-01

    The ongoing "Otolith" experiment is designed to comprehensively assess the otolith function during the re-adaptation phase after spaceflight. The novel protocol includes unilateral testing of each of the two otolith organs the utricle and the saccule. To assess utricle function, the otolith-ocular response (OOR) and the subjective visual vertical (SVV) are measured during unilateral centrifugation, which permits independent stimulation of the right and left ear. Measurement of the unilateral otolith-ocular response (uOOR) yields information on the response behaviour of the right and left peripheral utricles, whereas the SVV reflects the behaviour of the entire pathway from the peripheral otolith receptors to the vestibular cortex. Thus, by comparative evaluation of the results from the two tests, the degree of peripheral versus central adaptation during the post-flight period can be determined. To assess unilateral saccule function, vestibular evoked myogenic potentials (VEMP) are recorded. Since the saccules are predominantly aligned to gravity, and interplay with the antigravity muscles, it is hypothesised that these potentials shall be altered after spaceflight. To date the study has been conducted with 5 of a planned 8 short-flight Shuttle astronauts. Preliminary results will be discussed together with those from clinical studies of dizziness patients, where the same test protocol is employed. ACKNOWLEDGEMENT This work is supported by the German Aerospace Center (Grant DLR W130729) and is conducted under the auspices of ESA, in cooperation with NASA.

  15. Blood oxygen-level dependent functional assessment of cerebrovascular reactivity: Feasibility for intraoperative 3 Tesla MRI.

    Science.gov (United States)

    Fierstra, Jorn; Burkhardt, Jan-Karl; van Niftrik, Christiaan Hendrik Bas; Piccirelli, Marco; Pangalu, Athina; Kocian, Roman; Neidert, Marian Christoph; Valavanis, Antonios; Regli, Luca; Bozinov, Oliver

    2017-02-01

    To assess the feasibility of functional blood oxygen-level dependent (BOLD) MRI to evaluate intraoperative cerebrovascular reactivity (CVR) at 3 Tesla field strength. Ten consecutive neurosurgical subjects scheduled for a clinical intraoperative MRI examination were enrolled in this study. In addition to the clinical protocol a BOLD sequence was implemented with three cycles of 44 s apnea to calculate CVR values on a voxel-by-voxel basis throughout the brain. The CVR range was then color-coded and superimposed on an anatomical volume to create high spatial resolution CVR maps. Ten subjects (mean age 34.8 ± 13.4; 2 females) uneventfully underwent the intraoperative BOLD protocol, with no complications occurring. Whole-brain CVR for all subjects was (mean ± SD) 0.69 ± 0.42, whereas CVR was markedly higher for tumor subjects as compared to vascular subjects, 0.81 ± 0.44 versus 0.33 ± 0.10, respectively. Furthermore, color-coded functional maps could be robustly interpreted for a whole-brain assessment of CVR. We demonstrate that intraoperative BOLD MRI is feasible in creating functional maps to assess cerebrovascular reactivity throughout the brain in subjects undergoing a neurosurgical procedure. Magn Reson Med 77:806-813, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  16. Feasibility study for remote assessment of cognitive function in multiple sclerosis.

    Science.gov (United States)

    George, Michaela F; Holingue, Calliope B; Briggs, Farren B S; Shao, Xiaorong; Bellesis, Kalliope H; Whitmer, Rachel A; Schaefer, Catherine; Benedict, Ralph Hb; Barcellos, Lisa F

    2016-01-01

    Cognitive impairment is common in multiple sclerosis (MS), and affects employment and quality of life. Large studies are needed to identify risk factors for cognitive decline. Currently, a MS-validated remote assessment for cognitive function does not exist. Studies to determine feasibility of large remote cognitive function investigations in MS have not been published. To determine whether MS patients would participate in remote cognitive studies. We utilized the Modified Telephone Interview for Cognitive Status (TICS-M), a previously validated phone assessment for cognitive function in healthy elderly populations to detect mild cognitive impairment. We identified factors that influenced participation rates. We investigated the relationship between MS risk factors and TICS-M score in cases, and score differences between cases and control individuals. The TICS-M was administered to MS cases and controls. Linear and logistic regression models were utilized. 11.5% of eligible study participants did not participate in cognitive testing. MS cases, females and individuals with lower educational status were more likely to refuse (pTICS-M score among cases (pTICS-M score was significantly lower in cases compared to controls (p=0.007). Our results demonstrate convincingly that a remotely administered cognitive assessment is quite feasible for conducting large epidemiologic studies in MS, and lay the much needed foundation for future work that will utilize MS-validated cognitive measures.

  17. Quantitative gated SPECT- a comparative study of two algorithms for parameters of perfusion and LV function

    International Nuclear Information System (INIS)

    Ali, A.Z.

    2007-01-01

    Full text: Aim: To compare the perfusion and LV function parameters as quantified by 4D-MSPECT and ECT in the same patient group and a qualitative comparison of the reconstructed slices by two different experts. Materials and methods: Thirty-one consecutive patients underwent gated myocardial perfusion SPECT using a two-day protocol. The gated and ungated data were reconstructed by back projection method. Quantitative analysis was performed on the same set of reconstructed slices by 4D-MSPECT and Emory Cardiac Tool Box. The reconstructed slices were read qualitatively by two different experts on their respective systems. Polar map and functional analysis was performed in both softwares and the results were compared. Results: The concordance between the two experts qualitatively was seen in 78/93(84%) coronary territories. The polar map defects were comparable in LAD (r-value of 0.87) and LCX (r-value of 0.76) territories whereas RCA defects (r-value of 0.04) were not at all correlating. The defect severity showed concordance in 68/93 (73%) coronary territories. There was concordance between 4DMSPECT and the qualitative interpretation in 84/93 (90%) coronary territories whereas ECT showed concordance in only 70/93(75%) coronary territories. The overall sensitivity is marginally higher for ECT (100% vs. 96%) but the overall specificity is much higher with 4 DMSPECT (88% vs. 65%). ESV showed good correlation(r=0.94) of the two softwares with no significant difference in means. EDV and LVEF although had good correlation(r = 0.96 and 0.89) showed high difference in means (p<0.01). Conclusion: Between 4D-MSPECT and ECT, 4D-MSPECT is marginally superior to ECT with reference to qualitative interpretation in view of better specificity. The LVEF values between the two softwares should also not be used interchangeably. (author)

  18. Utility of TICS-M for the assessment of cognitive function in older adults.

    Science.gov (United States)

    de Jager, Celeste A; Budge, Marc M; Clarke, Robert

    2003-04-01

    Routine screening of high-risk elderly people for early cognitive impairment is constrained by the limitations of currently available cognitive function tests. The Telephone Interview of Cognitive Status is a novel instrument for assessment of cognitive function that can be administered in person or by telephone. To evaluate the determinants and utility of TICS-M (13-item modified version) for assessment of cognitive function in healthy elderly people. The utility of TICS-M was compared with more widely used MMSE and CAMCOG in a cross-sectional survey of 120 older (62 to 89 years) UK adults. The TICS-M cognitive test scores (27.97, SD 4.15) were normally distributed in contrast with those for MMSE and CAMCOG that had a negatively skewed distribution. TICS-M scores were inversely correlated with age (r = -0.21) and with the NART fullscale IQ (r = -0.35), but were independent of years of education in this cohort. TICS-M was highly correlated with MMSE (r = 0.57) and with CAMCOG (r = 0.62) scores. The time required to complete the test is comparable to MMSE and substantially less than CAMCOG. The normal distribution of TICS-M test scores suggest that this test is less constrained by the ceiling effect which limits the utility of MMSE and CAMCOG test scores in detecting early cognitive impairment. TICS-M is an appropriate instrument to assess cognitive function in both research and in clinical practice. Copyright 2003 John Wiley & Sons, Ltd.

  19. Dynamic {sup 18}F-fluoride small animal PET to noninvasively assess renal function in rats

    Energy Technology Data Exchange (ETDEWEB)

    Schnoeckel, Uta; Stegger, Lars; Schaefers, Klaus P.; Hermann, Sven; Schober, Otmar; Schaefers, Michael [Klinik und Poliklinik fuer Nuklearmedizin, Muenster (Germany); Reuter, Stefan; Schlatter, Eberhard; Gabriels, Gert [Universitaetsklinikum Muenster, Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Muenster (Germany)

    2008-12-15

    Renal function can be quantified by both laboratory and scintigraphic methods. In the case of small animal diagnostics, scintigraphic image-based methods are ideal since they can assess split renal function, work noninvasively, and can be repeated. The aim of this study is to validate a {sup 18}F-PET-based method to quantify renal function in rats. Fluoride clearance was calculated from a dynamic whole body listmode acquisition of 60 min length in a small animal PET scanner following an i.v. injection of 15 MBq {sup 18}F-fluoride. Volumes of interest (VOIs) were placed in the left ventricle and the bladder as well as traced around the kidney contours. The respective time-activity curves (TAC) were calculated. The renal {sup 18}F-clearance was calculated by the ratio of the total renal excreted activity (bladder VOI) and the integral of the blood TAC. PET-derived renal function was validated by intraindividual measurements of creatinine clearance (n=23), urea clearance (n=23), and tubular excretion rate (TER-MAG3). The split renal function was derived from the injection of the clinically available radionuclide {sup 99m}Tc-mercaptotriglycine by blood sampling and planar renography (n=8). In all animals studied, PET revealed high-quality TACs. PET-derived renal fluoride clearance was linearly correlated with intraindividual laboratory measures (PET vs. creatinine: r=0.78; PET vs. urea: r=0.73; PET vs. TER-MAG3: r=0.73). Split function was comparable ({sup 18}F-PET vs. MAG3-renography: r=0.98). PET-derived measures were highly reproducible. {sup 18}F-PET is able to noninvasively assess renal function in rats and provides a significant potential for serial studies in different experimental scenarios. (orig.)

  20. Dynamic 18F-fluoride small animal PET to noninvasively assess renal function in rats

    International Nuclear Information System (INIS)

    Schnoeckel, Uta; Stegger, Lars; Schaefers, Klaus P.; Hermann, Sven; Schober, Otmar; Schaefers, Michael; Reuter, Stefan; Schlatter, Eberhard; Gabriels, Gert

    2008-01-01

    Renal function can be quantified by both laboratory and scintigraphic methods. In the case of small animal diagnostics, scintigraphic image-based methods are ideal since they can assess split renal function, work noninvasively, and can be repeated. The aim of this study is to validate a 18 F-PET-based method to quantify renal function in rats. Fluoride clearance was calculated from a dynamic whole body listmode acquisition of 60 min length in a small animal PET scanner following an i.v. injection of 15 MBq 18 F-fluoride. Volumes of interest (VOIs) were placed in the left ventricle and the bladder as well as traced around the kidney contours. The respective time-activity curves (TAC) were calculated. The renal 18 F-clearance was calculated by the ratio of the total renal excreted activity (bladder VOI) and the integral of the blood TAC. PET-derived renal function was validated by intraindividual measurements of creatinine clearance (n=23), urea clearance (n=23), and tubular excretion rate (TER-MAG3). The split renal function was derived from the injection of the clinically available radionuclide 99m Tc-mercaptotriglycine by blood sampling and planar renography (n=8). In all animals studied, PET revealed high-quality TACs. PET-derived renal fluoride clearance was linearly correlated with intraindividual laboratory measures (PET vs. creatinine: r=0.78; PET vs. urea: r=0.73; PET vs. TER-MAG3: r=0.73). Split function was comparable ( 18 F-PET vs. MAG3-renography: r=0.98). PET-derived measures were highly reproducible. 18 F-PET is able to noninvasively assess renal function in rats and provides a significant potential for serial studies in different experimental scenarios. (orig.)

  1. Evaluation of the EndoPAT as a Tool to Assess Endothelial Function

    Directory of Open Access Journals (Sweden)

    M. Moerland

    2012-01-01

    Endothelial function was stable over a longer period of time in renally impaired patients (coefficient of variation 13%. Endothelial function in renally impaired and type 2 diabetic patients was not decreased compared to healthy volunteers (2.9±1.4 and 1.8±0.3, resp., versus 1.8±0.5, P>0.05. The EndoPAT did not detect an effect of robust interventions on endothelial function in healthy volunteers (glucose load: change from baseline 0.08±0.50, 95% confidence interval −0.44 to 0.60; smoking: change from baseline 0.49±0.92, 95% confidence interval −0.47 to 1.46. This suggests that at present the EndoPAT might not be suitable to assess (changes in endothelial function in early-phase clinical pharmacology studies. Endothelial function as measured by the EndoPAT could be physiologically different from endothelial function as measured by conventional techniques. This should be investigated carefully before the EndoPAT can be considered a useful tool in drug development or clinical practice.

  2. Medicine in words and numbers: a cross-sectional survey comparing probability assessment scales

    Directory of Open Access Journals (Sweden)

    Koele Pieter

    2007-06-01

    Full Text Available Abstract Background In the complex domain of medical decision making, reasoning under uncertainty can benefit from supporting tools. Automated decision support tools often build upon mathematical models, such as Bayesian networks. These networks require probabilities which often have to be assessed by experts in the domain of application. Probability response scales can be used to support the assessment process. We compare assessments obtained with different types of response scale. Methods General practitioners (GPs gave assessments on and preferences for three different probability response scales: a numerical scale, a scale with only verbal labels, and a combined verbal-numerical scale we had designed ourselves. Standard analyses of variance were performed. Results No differences in assessments over the three response scales were found. Preferences for type of scale differed: the less experienced GPs preferred the verbal scale, the most experienced preferred the numerical scale, with the groups in between having a preference for the combined verbal-numerical scale. Conclusion We conclude that all three response scales are equally suitable for supporting probability assessment. The combined verbal-numerical scale is a good choice for aiding the process, since it offers numerical labels to those who prefer numbers and verbal labels to those who prefer words, and accommodates both more and less experienced professionals.

  3. Functional characterization of sugarcane mustang domesticated transposases and comparative diversity in sugarcane, rice, maize and sorghum

    Directory of Open Access Journals (Sweden)

    Daniela Kajihara

    2012-01-01

    Full Text Available Transposable elements (TEs account for a large portion of plant genomes, particularly in grasses, in which they correspond to 50%-80% of the genomic content. TEs have recently been shown to be a source of new genes and new regulatory networks. The most striking contribution of TEs is referred as “molecular domestication”, by which the element coding sequence loses its movement capacity and acquires cellular function. Recently, domesticated transposases known as mustang and derived from the Mutator element have been described in sugarcane. In order to improve our understanding of the function of these proteins, we identified mustang genes from Sorghum bicolor and Zea mays and performed a phenetic analysis to assess the diversity and evolutionary history of this gene family. This analysis identified orthologous groups and showed that mustang genes are highly conserved in grass genomes. We also explored the transcriptional activity of sugarcane mustang genes in heterologous and homologous systems. These genes were found to be ubiquitously transcribed, with shoot apical meristem having the highest expression levels, and were downregulated by phytohormones. Together, these findings suggest the possible involvement of mustang proteins in the maintenance of hormonal homeostasis.

  4. A comparative review of Toll-like receptor 4 expression and functionality in different animal species

    Directory of Open Access Journals (Sweden)

    Céline eVAURE

    2014-07-01

    Full Text Available Toll-like receptors (TLRs belong to the pattern recognition receptor (PRR family, a key component of the innate immune system. TLRs detect invading pathogens and initiate an immediate immune response to them, followed by a long-lasting adaptive immune response. Activation of TLRs leads to the synthesis of pro-inflammatory cytokines and chemokines and the expression of co-stimulatory molecules. TLR4 specifically recognizes bacterial lipopolysaccharide (LPS, along with several other components of pathogens and endogenous molecules produced during abnormal situations, such as tissue damage. Evolution across species can lead to substantial diversity in the TLR4’s affinity and specificity to its ligands, the TLR4 gene and cellular expression patterns and tissue distribution. Consequently, TLR4 functions vary across different species. In recent years, the use of synthetic TLR agonists as adjuvants has emerged as a realistic therapeutic goal, notably for the development of vaccines against poorly immunogenic targets. Given that an adjuvanted vaccine must be assessed in pre-clinical animal models before being tested in humans, the extent to which an animal model represents and predicts the human condition is of particular importance. This review focuses on the current knowledge on the critical points of divergence between human and the mammalian species commonly used in vaccine research and development (non-human primate, mouse, rat, rabbit, swine and dog, in terms of molecular, cellular and functional properties of TLR4.

  5. Inverted Lobes Have Satisfactory Functions Compared With Noninverted Lobes in Lung Transplantation.

    Science.gov (United States)

    Kayawake, Hidenao; Chen-Yoshikawa, Toyofumi F; Motoyama, Hideki; Hamaji, Masatsugu; Hijiya, Kyoko; Aoyama, Akihiro; Goda, Yasufumi; Oda, Hiromi; Ueda, Satoshi; Date, Hiroshi

    2018-04-01

    To overcome the problem of small-for-size grafts in standard living-donor lobar lung transplantation (LDLLT), we developed inverted LDLLT, in which a right lower lobe from 1 donor is implanted as a right graft and another right lower lobe from another donor is implanted as a left graft. We retrospectively analyzed the functions of inverted grafts vs noninverted grafts. Between 2008 and 2015, 64 LDLLTs were performed. Included were 35 LDLLTs whose recipients were adults and monitored for more than 6 months without developing chronic lung allograft dysfunction. Among them, 65 implanted lobes were eligible for this analysis. There were 31 right lower lobes implanted as right grafts (right-to-right group), 7 right lower lobes as inverted left grafts (right-to-left group), and 27 left lower lobes as left grafts (left-to-left group). We evaluated the graft forced vital capacity (G-FVC) and graft volume of the 65 lobes before and 6 months after LDLLT and compared them among the three groups. Preoperatively, G-FVC in the right-to-left group (1,050 mL) was comparable to that in the right-to-right group (1,177 mL) and better than that in the left-to-left group (791 mL, p satisfactory compared with those of noninverted grafts. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  6. Development of a qPCR method to rapidly assess the function of NKT cells.

    Science.gov (United States)

    Sohn, Silke; Tiper, Irina; Japp, Emily; Sun, Wenji; Tkaczuk, Katherine; Webb, Tonya J

    2014-05-01

    NKT cells comprise a rare, but important subset of T cells which account for ~0.2% of the total circulating