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Sample records for funcionais da hdl

  1. PROPRIEDADES FUNCIONAIS DA CEVADA EM PRODUTO CÁRNEO

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    Aline Sobreira BEZERRA

    2013-04-01

    Full Text Available Objetivou-se avaliar a atividade funcional da cevada (Hordeum vulgare L. em formulações de linguiça suína com adição de diferentes percentuais de cevada adicionadas e isentas de gordura. Foram utilizadas no experimento as cultivares BRS Lagoa e MN 743, sendo esta última pré-selecionada para a elaboração da linguiça pelo seu alto teor de fibra solúvel e de compostos antioxidantes, tendo em vista suas propriedades funcionais no produto. Foram realizadas análises de fibra alimentar total e frações e de compostos antioxidantes por HPLC e Folin-Ciocalteau. As amostras de linguiça elaboradas foram conservadas a 5°C durante 23 dias e no 24° dia, submetidas a uma temperatura de 15°C por 24 horas visando acelerar o processo oxidativo. A determinação da oxidação foi realizada pelo teste do ácido 2-tiobarbitúrico (TBARS em mg de malonaldeído (MA por kg de amostra no 4°, 8°, 12°, 16° e 24° dia. Os resultados mostraram que nas preparações isentas de cevada, o índice de TBARS foi constante até o 12° dia, aumentando a partir do 16° dia de experimento. Com a adição de 10% de cevada, observou-se um aumento no 12° dia, mantendo valores baixos no 24° dia. Já na adição de 20% de cevada, os índices de TBARS não diferiram significativamente, permanecendo baixos ao longo do experimento. Logo, adições de cevada em percentuais de 10 e 20% exibiram efeito antioxidante na linguiça adicionada de gordura, agregando também uma quantidade significativa de fibra ao produto final.

  2. Alimentos funcionais no manejo da diabetes mellitus = Functional foods in the management of diabetes mellitus

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    Zaparolli, Marília Rizzon

    2013-01-01

    Full Text Available Objetivo: Analisar o conhecimento e o consumo de alimentos funcionais que auxiliam no controle da Diabetes mellitus em pacientes de um hospital público de Curitiba - PR. Materiais e Métodos: Trata-se de um estudo transversal e quantitativo, realizado com pacientes diabéticos hospitalizados (Hospital de Clínicas/UFPR, no período de dezembro de 2011 a março de 2012. Para a coleta de dados foi utilizado um questionário, através do qual se obteve informações sobre o conhecimento de alimentos funcionais e consumo de cinco alimentos funcionais importantes no controle da diabetes: alho, batata yacon, cebola, farinha de casca de maracujá e linhaça. Os dados coletados foram tabulados no programa Libre Office 3. 5® e após isso se realizou análise estatística descritiva. Resultados: Observou-se que somente 12 pacientes (35,29% da amostra haviam recebido informações anteriormente sobre alimentos funcionais e apenas 11 (32,35% responderam saber da importância desses alimentos no controle da diabetes. Dos cinco alimentos funcionais estudados, o alho e a batata yacon foram os que apresentaram maior consumo entre os diabéticos. Conclusão: O conhecimento de alimentos funcionais bem como seu consumo é pequeno por parte de pacientes diabéticos. Há a necessidade de uma maior intervenção por parte dos profissionais da Nutrição na orientação do consumo desses alimentos na dieta habitual dos diabéticos, visando promover um melhor controle da diabetes mellitus

  3. Alimentos funcionais : o impacto da rotulagem no comportamento do consumidor

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    Silva, Maria João Marques da

    2017-01-01

    O aumento da esperança de vida conduz um aumento da incidência de doenças crónicas tais como a diabetes, cancro e doenças cardiovasculares (associadas a problemas com colesterol). De uma forma geral, os consumidores estão cada vez mais preocupados em evitar o consumo de alimentos que podem ser prejudiciais ao organismo e ao mesmo tempo, aumentar o consumo de alimentos que podem contribuir para uma melhoria da qualidade de vida. Com o objetivo de minimizarem os custos asso...

  4. Propriedades funcionais de proteínas da clara do ovo de codorna

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    Santos, Daniela Oliveira dos

    2008-01-01

    Neste trabalho, estudaram-se as características funcionais de solubilidade, capacidade de formação de espuma e gelificação das proteínas da clara de ovo de codorna. Dados de solubilidade foram avaliados em função do tempo de agitação da solução protéica, do valor de pH e da concentração de sal (NaCl), à temperatura de 25 ºC. As propriedades espumantes e gelificantes foram avaliadas em função da concentração de proteína, do valor de pH e da concentração do sal. O conteúdo protéico do sobrenada...

  5. Alimentos funcionais no manejo da diabetes mellitus = Functional foods in the management of diabetes mellitus

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    Zaparolli, Marília Rizzon; Nascimento, Nayana Cavassim do; Baptista, Deise Regina; Vayego, Stela Adami

    2013-01-01

    Objetivo: Analisar o conhecimento e o consumo de alimentos funcionais que auxiliam no controle da Diabetes mellitus em pacientes de um hospital público de Curitiba - PR. Materiais e Métodos: Trata-se de um estudo transversal e quantitativo, realizado com pacientes diabéticos hospitalizados (Hospital de Clínicas/UFPR), no período de dezembro de 2011 a março de 2012. Para a coleta de dados foi utilizado um questionário, através do qual se obteve informações sobre o conhecimento de alimentos fun...

  6. PROPRIEDADES FUNCIONAIS DAS PROTEÍNAS DE AMÊNDOAS DA MUNGUBA (Pachira aquatica Aubl.

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    BERNADETE DE LOURDES DE ARAÚJO SILVA

    2015-03-01

    Full Text Available RESUMO A semente da munguba (Pachira aquatica Aubl. contém amêndoas que exibem um conteúdo excelente de óleo e um percentualsignificativo em proteínas. Propositou-se determinar algumas propriedades funcionais das proteínas de amêndoas damunguba com o objetivo de instituir sua utilização na indústria de alimentos. O teor lipídico foi de 46,62%, o proteico de 13,75% e na forma de torta apresentou um índice de 28,27% de proteínas. Obtiveram-se doisisolados proteicos, o IP 2,0 e o IP 10,0, decorrentes de duas condições de pH (2,0 e 10,0. Na obtenção dos isolados proteicos, os índices em proteínas extraídas foram de 38,52% para o IP 2,0 e 82,06% para o IP 10,0. Os índices de proteínas recuperadas através da precipitação isoelétrica foram de 23,35% para o IP 2,0 e de 70,94%para o IP 10,0, em pH 5,0. As propriedades funcionais exibiram solubilidade mínima em pH 5,0, no pontoisoelétrico (pI, sendo mais elevada em pH ácido e alcalino do pI. As melhores capacidades de absorçãode água e de óleo exibidas foram para o IP 10,0. As propriedades emulsificantes foram dependentes do pH para os dois isolados, e o IP 10,0 indicou melhores resultados. As propriedades funcionais estudadas permitem o emprego dos isolados proteicos em produtos alimentícios que requerem alta solubilidade, tais como os produtos de panificação, massas em geral, sopas desidratadas e molhos, produtos que exigem desempenho na absorção do óleo, como as carnes simuladas, e em produtos que requerem poderes emulsificantes.

  7. Propriedades funcionais da semente do sorgo (Sorghum bicolor (L. Moench in natura e germinado

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    D. D. F. Leite

    2016-01-01

    Full Text Available A utilização de sementes germinadas na elaboração de produtos alimentícios com boa qualidade nutricional é uma possibilidade e o sorgo pode se apresentar como alternativa ao consumo dos cereais convencionais. O objetivo deste estudo foi de observar as alterações nos parâmetros físico-químicos da semente de sorgo antes e após o processo de germinação, assim como avaliar as propriedades funcionais indicando suas possíveis utilizações como ingrediente alimentar. As sementes germinadas apresentaram um aumento no teor proteico, passando de 4,32 para 7,20%, além da diminuição no teor de amido e consequente aumento no teor de açúcares redutores. A partir das propriedades funcionais avaliadas, a semente de sorgo germinada apresentou uma boa capacidade de absorção de óleo, podendo ser utilizado como ingrediente para auxiliar na textura e suculência de produtos. A germinação garantiu boa capacidade de formação de espuma e sua estabilidade, podendo ser utilizado como ingrediente em produtos alimentícios de fermentação, como bolos e biscoitos, além de bom agente de formação de gel podendo ser útil em sistemas alimentícios como pudim e lanches, que requerem espessamento e gelificação.Properties of sorghum seed Functional (Sorghum bicolor (L. Moench in natura and germinatedAbstract: The use of germinated seeds in the preparation of food products with good nutritional quality is a possibility and sorghum can be presented as an alternative to the consumption of conventional cereals. The objective of this study was to observe the changes in physical and chemical parameters of sorghum seed before and after the germination process, and assess the functional properties indicating their possible use as a food ingredient. Germinated seeds showed an increase in protein content, from 4.32 to 7.20% in addition to the decrease in the starch content and the consequent increase in reducing sugars. From the functional properties

  8. ASPECTOS FUNCIONAIS DA ORDEM DE CONSTITUINTES Functional Aspects of Order of Constituents

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    Erotilde Goreti Pezatti

    1997-08-01

    Full Text Available O objetivo deste trabalho é fornecer uma interpretação funcional para a ordem de constituintes da sentença do português falado no Brasil (PB. Segundo a metodologia aqui adotada, as generalizações de natureza sintática decorrem necessariamente de generalizações de natureza semântica e pragmática. Os dados constituem uma amostragem representativa de sentenças do português falado, extraída de inquéritos do Projeto NURC. Como enfoque funcional prevê a coexistência de diferentes padrões de ordenação de constituintes, usados em diferentes condições e para diferentes propósitos, postula-se que o PB dispõe de dois padrões igualmente relevantes: a ordem SVO e a ordem VSO, ambos pragmaticamente motivados. Argumenta-se ainda que tais motivações pragmáticas relaciona, diacronicamente, os padrões funcionais em uso a uma mudança em curso na classificação tipológica do PB de um tipo primitivo VSO para o tipo SVO atualmente predominante.The aim of this paper is to provide a functional interpretation for sentence word order of spoken Brazilian Portuguese (BP. According to the methodology adopted, generalisations of syntactic nature result necessarily from generalisations of semantic and pragmatic nature. The data constitute a representative sentence sampling of spoken Portuguese, drawn from interviews recorded by NURC Project. Since the functional approach considers the co-existence of different word order patterns, used in different conditions and for different purposes, this paper postulates that BP is endowed with two patterns, both equally relevant and pragmatically motivated: SVO and VSO order. It is also argued that such pragmatic motivations relate both patterns diachronically to a possible change in progress in BP typological classification that follows from a primitive VSO type to the actually prevailing SVO type.

  9. MONITORAMENTO DA PROPAGANDA DE LEITES FERMENTADOS COM ALEGAÇÕES DE PROPRIEDADES FUNCIONAIS E A PROTEÇÃO DA SAÚDE

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    Larissa P. Brumano

    2011-06-01

    Full Text Available No Brasil, a categoria de alimentos com alegações de propriedades funcionais tem obrigatoriedade de registro na Agência Nacional de Vigilância Sanitária (ANVISA. No caso dos leites fermentados com alegações de propriedades funcionais, o registro do produto ocorre no Ministério da Agricultura Pecuária e Abastecimento após a aprovação das alegações pela ANVISA. A fiscalização das propagandas destes alimentos é competência da ANVISA. Não são permitidas alegações que façam referência à cura ou à prevenção de doenças. Probióticos são microrganismos vivos, administrados em quantidades adequadas, que conferem benefícios à saúde do hospedeiro. A alegação padronizada para probióticos é: "O (indicar a espécie do microrganismo (probiótico contribui para o equilíbrio da flora intestinal. Seu consumo deve estar associado a uma dieta equilibrada e hábitos de vida saudáveis". Irregularidades na propaganda de alimentos com alegações de propriedades funcionais podem causar danos à saúde do consumidor, o que caracteriza risco sanitário. O objetivo deste trabalho foi contribuir para a proteção da saúde pública por meio da análise da conformidade das propagandas de leites fermentados com alegações de propriedades funcionais em relação à legislação. Observou-se a predominância de anúncios de produtos que continham o microrganismo Lactobacillus casei Shirota (61,1%, seguido por anúncios de produtos com Bifidobacterium animalis (33,3% e com Lactobacillus casei defensis (5,5%. Concluiu-se que a totalidade das amostras esteve em desacordo com a legislação em pelo menos um requisito. Ressalta-se a necessidade de maior esforço por parte dos órgãos de registro de alimentos e de fiscalização da propaganda para adequá-las à legislação.

  10. COMPOSIÇÃO CENTESIMAL E PROPRIEDADES FUNCIONAIS TECNOLÓGICAS DA FARINHA DA CASCA DO MARACUJÁ

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    M. W. S. SOUZA

    2008-12-01

    Full Text Available

    A maior incidência de doenças crônicodegenerativas deve-se, em grande parte, à redução do consumo das fi bras na dieta. Estes nutrientes apresentam efeitos fi siológicos importantes e uma alternativa para aumentar o seu consumo pela população é a utilização de resíduos industriais, como cascas e talos de frutas e vegetais. Este trabalho teve como objetivo analisar a composição centesimal da farinha da casca do maracujá, assim como seu teor de fi bras totais e suas propriedades funcionais tecnológicas, e a partir destes dados avaliar a possibilidade de sua utilização como fonte de fibras no enriquecimento nutricional de produtos. A análise da farinha da casca do maracujá indicou um alto teor de fi bra alimentar (66,37 ± 0,71g/100g e as análises das propriedades funcionais tecnológicas apontaram uma alta capacidade de retenção, absorção e adsorção de água. Assim, conclui-se que a farinha da casca do maracujá tem potencial para ser incluída na dieta como uma fonte de fi bras, podendo ser utilizada no enriquecimento de produtos como pães, biscoitos e barras de cereais, melhorando suas qualidades nutricionais e tecnológicas, além de ser uma alternativa para reduzir o desperdício de subprodutos da indústria alimentícia.

  11. Sistema da cadeia agro-alimentar : critério : saúde/bem-estar : alimentos funcionais

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    Moura, Ana Pinto de

    2011-01-01

    Neste documento (slides) considera-se a problemática do critério: Saúde nas escolhas alimentares do consumidor, particularizando a análise para o caso dos Alimentos Funcionais. Este documento deve ser lido em sintonia com o texto de apoio sobe o mesmo tema.

  12. Análise da organização competitiva de crianças e jovens: adaptações estruturais e funcionais

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    Michel Milistetd

    2014-09-01

    Full Text Available O objetivo da presente pesquisa foi analisar a organização de competições em federações esportivas de diferentes modalidades. A partir da análise de documentos oficiais, foram avaliadas 14 federações esportivas e suas respectivas idades de início da participação competitiva, a divisão de categorias, alterações estruturais e alterações funcionais. Os resultados encontrados apontam que o início das competições oficiais em todas as modalidades esportivas, com exceção do atletismo e da natação, ocorre antes dos 10 anos de idade. Com relação às modificações estruturais, a federação de futebol é a que menos propõe mudanças, alterando apenas o seu tempo de jogo. As federações de basquetebol, handebol e ginástica estabelecem o maior número de mudanças estruturais, respeitando as particularidades do público infantojuvenil. Quanto às modificações funcionais, a federação de voleibol apresenta o maior número de alterações, que se referem à execução de fundamentos (saque, bloqueio, ações de jogo (levantamento, número de atacantes e limitações táticas nas primeiras categorias. As alterações apresentadas pelas federações paranaenses revelam clara preocupação com adaptações para o melhor aproveitamento da prática esportiva pelos jogadores, respeitando pressupostos pedagógicos da formação esportiva a longo prazo. No entanto, o início do envolvimento competitivo parece ocorrer antes das idades recomendadas pela literatura especializada, favorecendo o surgimento de um quadro de especialização esportiva precoce destes jovens atletas.

  13. Os alimentos funcionais: a nova fronteira da indústria alimentar análise das estratégias da Danone e da Nestlé no mercado brasileiro de iogurtes

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    Cécile Raud

    2008-11-01

    Full Text Available Os alimentos funcionais, que prometem ajudar na cura ou na prevenção de doenças, são a nova tendência do poderoso mercado alimentício neste início do século XXI. Iogurtes, margarinas, leites fermentados, cereais, águas minerais etc. prometem ajudar na cura ou na prevenção de doenças como as cardiovasculares, certos tipos de câncer, alergias, problemas intestinais etc. Entre os fatores-chave que explicam o êxito dos alimentos funcionais, há a preocupação crescente pela saúde e pelo bem-estar, mudanças na regulamentação dos alimentos e a crescente comprovação científica das relações existentes entre dieta e saúde. Escolhemos analisar e comparar as estratégias de duas multinacionais (Danone e Nestlé que se enfrentam nas gôndolas dos supermercados brasileiros para dominar o mercado dos iogurtes funcionais. O Activia, da Danone, foi lançado com êxito em diversos países europeus, em meados da década de 1990, e no mercado brasileiro, em 2004, levando a uma considerável revitalização do mercado dos produtos lácteos. Em reação, a Nestlé lançou o Nesvita, em junho de 2006. Com base na Nova Sociologia Econômica, verificamos a existência de lutas no mercado, em que a inovação e o lançamento de novos produtos são necessidades para as empresas que pretendem manter ou estabelecer sua liderança. Nesse campo de lutas, o Estado desempenha um papel fundamental, ao definir as regras do jogo entre os parceiros da troca e entre os concorrentes.

  14. ACURÁCIA DE TESTES FUNCIONAIS NA IDENTIFICAÇÃO DA PRÉ-ATIVAÇÃO DE MÚSCULOS LOMBOPÉLVICOS

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    Fabrício José Jassi

    Full Text Available RESUMO Introdução: Ajustes antecipatórios (pré-ativação dos músculos profundos do tronco aumentam a estabilidade lombopélvica. Estudos prévios demonstram que indivíduos assintomáticos podem apresentar atrasos no início de ativação muscular e alterações físico-funcionais. No entanto, não foram encontrados estudos que tenham verificado se testes físico-funcionais (TFF são capazes de identificar alteração no início de ativação dos músculos estabilizadores lombopélvicos. Objetivo : Verificar os níveis de sensibilidade, especificidade e acurácia de um conjunto de testes de avaliação da capacidade física funcional para detectar alterações na pré-ativação dos músculos transverso do abdome/oblíquo interno (TrA/OI e multífido lombar (ML durante o teste de movimento rápido de flexão do ombro (TMRFO. Método : Participaram do estudo 27 voluntários assintomáticos para dor lombar, com média de idade de 23,8 anos (desvio padrão: 2,2, e que foram submetidos aos TFF e TMRFO para determinação do início da ativação dos músculos profundos do tronco por meio da eletromiografia de superfície. Foi verificada sensibilidade e especificidade e análise da acurácia através da curva ROC (Receiver Operating Characteristic e teste de qui-quadrado para comparações entre porcentagens (p < 0,05 . Resultados : A "pré-ativação" foi a condição que ocorreu com maior frequência no grupo como um todo, bem como em ambos os gêneros, com exceção do TrA/OI no gênero feminino (χ2 = 0,28/P = 0,58. Entre todos os TFF aplicados, o de enrolamento repetitivo do tronco apresentou maior valor de sensibilidade, especificidade e área sob a curva ROC (0,75; 0,73; 0,74, respectivamente . Conclusão : Entre os TFF avaliados, o de enrolamento repetitivo do tronco mostrou níveis aceitáveis de acurácia para identificar alterações na ativação da musculatura estabilizadora lombopélvica em voluntários assintomáticos para dor

  15. Resultados funcionais da aplicação da toxina botulínica tipo A em pacientes com acidente vascular cerebral

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    Vanessa Ribas Massia

    2009-01-01

    O Acidente Vascular Cerebral (AVC), junto com as demais doenças cerebrovasculares, é a terceira causa de óbito em países desenvolvidos e a principal causa de incapacidade em adultos. A espasticidade é a seqüela motora mais incapacitante, limitando as atividades funcionais. A toxina Botulínica (TB) tem se mostrado uma opção terapêutica benéfica, eficaz e segura. Pacientes submetidos à aplicação de TB devem iniciar um tratamento fisioterapeutico a fim de estabelecer a função perdida, tornando-o...

  16. Necessidades próprias da (cidade: espaços acessíveis e funcionais para idosos*

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    Nayara Mendes Silva

    2015-12-01

    Full Text Available A transição demográfica consiste uma realidade brasileira. Condições de acessibilidade e funcionalidade possibilitam compreender sobre aspectos que possam contribuir com a inclusão sócioespacial da população. O objetivo deste trabalho é verificar aspectos relativos à acessibilidade em um núcleo habitacional para idosos de baixa renda de um município do interior paulista, considerando: moradias, espaços intramuros e entorno. Visa explorar formas de aplicar recursos públicos em prol de melhorias à população, com diferentes atores sociais. O estudo é exploratório, descritivo e observacional participante. Análise de conteúdo a partir do tema em estudo. Ausência de critérios técnicos e de equipamentos que suportem um ambiente acessível, tanto de edificações quanto urbano foi identificada, produzindo dificuldades ao acesso a outros espaços, à mobilidade, tanto no ambiente do núcleo quanto nas imediações. Minimizar problemas sobre condições de mobilidade e acessibilidade no condomínio e no entorno colabora para preservar a independência e segurança do morador, reforça a função social das cidades uma vez que possibilita o exercício do direito de ir e vir, consagrado à moradia digna. Captar recursos, por meio, do uso do Termo de Ajustamento de Conduta-TAC, junto ao Ministério Público, pode ser uma estratégia para (reutilizar recursos públicos em prol de si mesmo.

  17. Estudo da reação de quebra de polímeros com H5IO6 para obtenção de polímeros com terminações funcionais

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    Mauler, Raquel Santos; Galland, Griselda Ligia Barrera; Samios, Dimitrios; Guaragna Martins, Fernando; Gobbi, Delton L.

    1992-01-01

    A obtenção de polímeros com terminações funcionais foi possível pela quebra oxidativa de duplas ligações carbono-carbono em polímeros insaturados pela utilização do ácido periódico (H5IO6). Neste trabalho foram utilizadas a borracha natural "Hevea Brasiliensis", SBR e NBR onde foi obtida a funcionalidade terminal carbonílica. O decréscimo do peso molecular, decorrente da quebra da cadeia, é uma função do tempo de reaçào e da temperatura. Aparentemente é influenciado, também, pelo solvente e a...

  18. Acurácia da ultrassonografia e da avaliação comportamental na determinação das características funcionais de estruturas ovarianas císticas

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    Miller Pereira Palhão

    2014-10-01

    Full Text Available O objetivo deste trabalho foi avaliar a acurácia da ultrassonografia e da sintomatologia em determinar características funcionais de estruturas ovarianas císticas. Em 51 vacas Girolando sem corpo lúteo, foram avaliados: presença ou ausência de tecido luteal na parede do folículo; concentrações séricas de progesterona (P4; e sinais comportamentais dos animais (anestro ou ninfomania. As concentrações plasmáticas de P4 foram consideradas como padrão ouro. A avaliação ultrassonográfica foi um método preciso (82,4% para diagnosticar o tipo de cisto folicular. O anestro está relacionado à presença de cisto luteinizado e à elevada P4. Os cistos não luteinizados são frequentemente encontrados em animais com baixa P4, que apresentam comportamento de anestro ou ninfomania.

  19. Os efeitos dos aparelhos funcionais sobre a dimensão transversal da maxila e mandíbula The effects of functional appliances in the maxilla and mandibular transverse dimension

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    Adriano Marotta Araújo

    2005-04-01

    Full Text Available Enquanto os efeitos dos aparelhos ortopédicos funcionais sobre as dimensões ântero-posterior e vertical vêm sendo amplamente estudados, o efeito sobre a dimensão transversal é um campo limitado e pouco explorado. A presença de escudos vestibulares, a pressão muscular, tração periostal e o reposicionamento lingual são alguns dos tópicos que podem influenciar o crescimento transversal da maxila e mandíbula. Vários estudos mostram uma alteração transversal dos arcos dentários, como resposta da terapia com o aparelho funcional. Baseado em uma revisão sistemática da literatura esse trabalho teve como objetivo: 1 avaliar os mecanismo de ação dos aparelhos e a influência sobre a dimensão transversal e 2 resumir os efeitos clínicos de diferentes aparelhos funcionais sobre a dimensão transversal.While the effects of functional appliances on the antero-posterior and vertical dimensions have been well studied, the literature pertaining to their transverse effects is limited and has not previously been synthesized. Buccal muscular pressure, periostal traction, and tongue repositioning are some of the proposed mechanisms by which transverse jaw dimensions could change during treatment. Various studies have reported transverse dental arch changes, but the effects appear to be dependent on the functional appliance used. Based on a systematic review of the literature, the purpouse of this paper are: 1 evaluated the proposed mechanisms that influence the transverse dimensions during treatment and 2 summarizes the clinical effects of various functional appliances on transverse jaw dimensions.

  20. Efeito da acidificação nas propriedades físico-químicas e funcionais do amido de sementes de manga (Mangifera indica L., variedade Tommy Atkins

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    Marianne Louise Marinho Mendes

    2015-06-01

    Full Text Available No processamento industrial da manga, os subprodutos, caroço e casca são, normalmente, descartados sem o devido aproveitamento. O objetivo deste trabalho foi investigar as características físico-químicas e funcionais dos amidos nativo e acidificado do caroço (amêndoa de manga, da variedade Tommy Atkins, pesquisando uma nova fonte de amido e formas de melhorá-la e contribuir para a utilização de resíduos da indústria alimentícia. As amêndoas foram retiradas manualmente dos caroços de manga e procedeu-se a extração do amido. O amido nativo foi acidificado, sendo o agente promotor da modificação o ácido clorídrico. Verificou-se a composição química do amido nativo. Determinaram-se também as propriedades funcionais e de pasta do amido nativo e do acidificado. Para a composição centesimal, o amido nativo apresentou 71,56% de amido, 7,30% de lipídeos e 5,6% de proteínas. Os amidos nativo e acidificado demonstraram baixa resistência à elevação da temperatura, com intumescimento máximo a 75 oC, sendo seus valores 9,395 e 6,861 g/g, respectivamente. A solubilidade mostrou-se crescente, à medida que houve elevação da temperatura, sendo seu valor máximo 48,03% para o amido acidificado. O amido nativo expôs maior capacidade de absorção de água, óleo e claridade da pasta. O referido amido ainda apresentou maior pico de viscosidade, viscosidade mínima, quebra de viscosidade, viscosidade final, retrogradação e temperatura de pasta do que os do amido acidificado. O amido nativo pode ser indicado para compor sopas desidratadas e produtos cárneos, enquanto o acidificado pode ser usado em alimentos congelados e refrigerados e na indústria de balas.

  1. Importância da HDL-c para a ocorrência de doença cardiovascular no idoso La importancia del HDL-c para la ocurrencia de la enfermedad cardiovascular en el adulto mayor Importance of HDL-c for the occurrence of cardiovascular disease in the elderly

    Directory of Open Access Journals (Sweden)

    Elizabete Viana de Freitas

    2009-09-01

    Full Text Available FUNDAMENTO: Estudos sobre o impacto da HDL-c e ocorrência de doença cardiovascular (CV em idosos são escassos. OBJETIVO: Avaliar as variáveis clínicas e laboratoriais e a ocorrência de eventos CV em idosos estratificados de acordo com o comportamento da HDL-c em seguimento de oito anos. MÉTODOS: Foram avaliados, em dois momentos (A1 e A2, com espaço mínimo de cinco anos, 81 idosos, com idade média de 68,51 ± 6,32 (38,2% do sexo masculino. Os indivíduos foram divididos em 3 grupos de acordo com o nível da HDL-c: HDL-c normal nas duas avaliações (GN (n=31; HDL-c baixa nas duas avaliações (GB (n=21; e HDL-c variável de A1 para A2 (GV (n=29. Foram registrados os eventos CV maiores: doença coronariana (angina, infarto miocárdio, revascularização miocárdica percutânea/cirúrgica, acidente vascular encefálico, acidente isquêmico transitório, doença carotídea, demência e insuficiência cardíaca. RESULTADOS: Os grupos não diferiram quanto à idade e sexo em A1 e A2. As médias dos triglicérides foram menores no GN em A1 (p=0,027 e A2 (p=0,016 que no GB. Já a distribuição de eventos CV foi de 13 eventos no GN (41,9%, 16 (76,2% no GB e de 12 (41,4% no GV (χ2=7,149, p=0,024. Em análise de regressão logística observou-se que quanto maior a idade (OR=1,187, p=0,0230 e quanto menor a HDL-c (OR=0,9372, p=0,0102, maior a ocorrência de eventos CV. CONCLUSÃO: O HDL-c permanentemente baixo ao longo de oito anos de acompanhamento foi fator de risco para desenvolvimento de eventos CV em idosos.FUNDAMENTO: Estudios sobre el impacto del HDL-c y ocurrencia de enfermedad cardiovascular (CV en adultos mayores son raros. OBJETIVO: Evaluar las variables clínicas y laboratoriales y la ocurrencia de eventos CV en adultos mayores estratificados según el comportamiento del HDL-c en seguimiento de ocho años. MÉTODOS: Se evaluaron, en dos momentos (A1 y A2, con espacio mínimo de cinco años, a 81 adultos mayores, con edad promedio de

  2. Metadados digitais: revisão bibliográfica da evolução e tendências por meio de categorias funcionais 10.5007/1518-2924.2007v12n23p16

    Directory of Open Access Journals (Sweden)

    Luiz Fernando de Barros Campos

    2007-11-01

    Full Text Available Revisão bibliográfica sobre metadados digitais no campo da ciência da informação, objetivando precisar as várias funcionalidades dos metadados. Empregando-se uma técnica de análise de conteúdo temática, constatou-se a recorrência de tecnologias como XML, RDFS, ontologias, data warehouses, Web Semântica, serviços Web, entre outras, e de dez categorias relativas às funções dos metadados que fundamentavam os textos examinados. Com suporte na análise temática, adotando-se uma perspectiva técnica e histórica, relacionaram-se as categorias funcionais às tecnologias e mostrou-se como as categorias são tratadas em dezenove dos artigos revisados, destacando-se as ênfases empregadas e a convergência dos temas. Notou-se que trabalhos e tecnologias que versam sobre padrões e modelos para preservação digital adotam perspectivas mais abrangentes e integradas, incorporando todas ou quase todas as categorias. Com base nos resultados, foram comentadas tendências e questões latentes percebidas na revisão bibliográfica, e sugeridas abordagens e metodologias para a análise de metadados e das tecnologias relacionadas.

  3. Suplementação nutricional com antioxidantes naturais: efeito da rutina na concentração de colesterol-HDL

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    Rodrigues Hosana Gomes

    2003-01-01

    Full Text Available O estresse oxidativo está freqüentemente associado com alterações nas concentrações séricas de glicose e lipídios. O objetivo deste trabalho foi verificar se as alterações bioquímicas séricas, induzidas pela suplementação nutricional com o flavonóide rutina, estão associadas a propriedades antioxidantes. A administração de rutina (120mg/kg/semana, durante 15 dias, não induziu variação na glicemia de jejum e no teste de tolerância à glicose. Embora não tenham sido observadas mudanças significativas nas concentrações séricas de lipoperóxidos, triacilglicerois, colesterol-LDL e proteínas totais, a suplementação nutricional com rutina demonstrou importante papel na prevenção da aterosclerose, pois induziu elevação significativa da lipoproteína de alta densidade (colesterol-HDL de 35,82 ± 2,31mg/dL para 44,40 ± 3,11mg/dL. Como não foram observadas alterações na glutationa peroxidase, enquanto as atividades da superóxido dismutase foram elevadas pela ingestão de rutina. Pode-se concluir que os efeitos antioxidantes deste flavonoide, aumentando a concentração de colesterol-HDL, estão relacionados à elevação nas atividades da superóxido dismutase. A ação antioxidante da rutina pode estar relacionada à destruição do radical superóxido (O2-.

  4. Síndrome da fragilidade e sua relação com aspectos emocionais, cognitivos, físicos e funcionais em idosos institucionalizados

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    Pâmella Martim Fernandes

    2015-05-01

    Full Text Available O objetivo do estudo foi avaliar a fragilidade de idosos residentes em uma Instituição de Longa Permanência da cidade de Santos (SP e correlacionar aspectos da síndrome manifesta com sintomas depressivos, desempenho cognitivo, físico e funcional nessa população. Foram avaliados 20 idosos institucionalizados, sendo estes na sua maioria (n=18; 90%, classificados como frágeis, e correlacionando-se com deficit cognitivo (r=-0,470; p=0,04, baixo desempenho físico (r=-0,437; p=0,05, e funcional (r=-0,529; p=0,02 na população estudada.  

  5. Influência da espessura de biofilmes feitos à base de proteínas miofibrilares sobre suas propriedades funcionais Thickness effects of myofibrillar protein based edible films on their functional properties

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    PAULO JOSÉ DO AMARAL SOBRAL

    2000-06-01

    Full Text Available O emprego potencial de filmes comestíveis e biodegradáveis em embalagens é condicionado pelas suas propriedades funcionais, que são influenciadas por muitos fatores, inclusive pela espessura. O objetivo deste trabalho foi estudar a influência da espessura dos biofilmes feitos à base de proteínas miofibrilares (de carne bovina e de tilápia-do-nilo sobre suas propriedades funcionais. Os biofilmes foram preparados a partir de uma solução filmogênica com 1 g de proteínas/100 g de solução. A concentração de plastificante foi de 45 g de glicerina/100 g de proteínas, e o pH foi mantido em 2,7. Após secagem, os filmes foram acondicionados em dessecadores a 58% de umidade relativa e 22°C, por quatro dias. As propriedades mecânicas foram determinadas por teste de perfuração; a permeabilidade ao vapor de água, por um método gravimétrico, e a cor e a opacidade, com colorímetro HunterLab, a 22°C. A força na perfuração, a permeabilidade ao vapor de água, a diferença de cor e a opacidade dos dois biofilmes aumentaram linearmente com a espessura dos corpos-de-prova. A deformação na perfuração foi pouco dependente da espessura e apresentou grande dispersão, em ambos os filmes. A taxa de permeabilidade ao vapor de água diminuiu linearmente com a espessura.Research on edible and biodegradable films had been promoted recently because of environmental concerns. The use of these materials for packaging applications is conditioned by their functional properties, which are influenced by many factors, including thickness. The objective of this work was to study the influence of thickness of myofibrillar protein-based biofilms on some of their functional properties. Biofilms were prepared from film forming solutions (FFS containing 1 g of protein/100 g of FFS. The plasticizer concentration was 45 g glycerin/100 g of protein and the pH was kept at 2.7. After drying, biofilms were conditioned in desiccators at 58% relative humidity and

  6. Associação entre déficit visual e aspectos clínico-funcionais em idosos da comunidade Association between visual deficit and clinical-functional characteristics among community-dwelling older adults

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    Lívia C. Luiz

    2009-10-01

    Full Text Available OBJETIVO: Identificar os fatores funcionais associados com o déficit visual em idosos da comunidade. MÉTODOS: Foram avaliados 96 idosos quanto à acuidade visual por meio da tabela direcional de Snellen e categorizados em relação à baixa visão (acuidade visual 0,3. Os fatores funcionais analisados foram: número de quedas, presença de doenças visuais, saúde mental, pela Geriatric Depression Scale (GDS, funcionalidade nas atividades diárias pelo Brazilian OARS Multidimensional Functional Assessment Questionnaire (BOMFAQ e a mobilidade funcional pelo Timed Up & Go Test (TUG. A análise inferencial foi realizada por meio dos testes Qui-Quadrado, Mann-Whitney e Coeficiente de Correlação de Spearman, considerando α=0,05. RESULTADOS: Apresentaram baixa visão 17,7% (n=17 dos idosos. Em relação aos idosos com visão normal, os idosos com baixa visão apresentaram idade mais avançada (pOBJECTIVE: To identify functional factors associated with visual deficits among community-dwelling older adults. METHODS: Ninety-six older adults were assessed for visual acuity by means of the Snellen Eye Chart and categorized as low vision (visual acuity 0.3. The functional factors analyzed were the number of falls, presence of eye diseases, mental health according to the Geriatric Depression Scale (GDS, functional status in daily activities according to the Brazilian OARS Multidimensional Functional Assessment Questionnaire (BOMFAQ and functional mobility according to the Timed Up & Go Test (TUG. Inferential analysis was performed using the chi-square test, Mann-Whitney test and Spearman correlation coefficient, taking α=0.05. RESULTS: Low vision was found in 17.7% (n=17 of the older adults. Compared to the older adults with normal vision, those with low vision had more advanced age (p<0.001 and more eye and adnexa diseases (p=0.023, higher scores for depressed mood (p=0.002, worse balance in the TUG (p=0.003 and higher numbers of impaired instrumental

  7. Implante coclear em crianças pós-linguais: resultados funcionais após 10 anos da cirurgia Cochlear implant in postlingual children: functional results 10 years after the surgery

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    Liege Franzini Tanamati

    2012-04-01

    Full Text Available Os benefícios do implante coclear (IC às habilidades comunicativas são obtidos ao longo de anos de uso. Há poucos estudos sobre os resultados a longo prazo em crianças pós-linguais que cresceram usando o dispositivo. OBJETIVO: Reportar os resultados funcionais em crianças pós-linguais, após 10 anos de uso do dispositivo. MATERIAL E MÉTODO: Dez crianças pós-linguais, implantadas antes dos 18 anos, participaram deste estudo. Foram avaliadas: a percepção da fala para sentenças e a inteligibilidade de fala. Informações sobre o uso/funcionamento do dispositivo e nível acadêmico/ocupacional foram documentadas. Desenho científico: Estudo de série. RESULTADOS: O reconhecimento para sentenças no silêncio foi igual a 73% e, no ruído, 40%. Para o método de transcrição, a média de acertos foi igual a 92% e, na escala de inteligibilidade, 4.15. Não houve falhas no dispositivo interno. Três participantes haviam concluído o ensino superior e, outros cinco, o ensino médio. Oito participantes estavam empregados. CONCLUSÃO: Este estudo mostrou que o IC é um procedimento seguro e confiável. As crianças pós-linguais após 10 anos de uso do IC alcançaram resultados funcionais em relação à percepção e a inteligibilidade da fala, concluíram ao menos o ensino superior e estavam inseridas no mercado de trabalho.The benefits of cochlear implants (CI for communication skills are obtained over the years. There are but a few studies regarding the long-term outcomes in postlingual deaf children who grew up using the electronic device. AIM: To assess the functional results in a group of postlingual children, 10 years after using a CI. METHODS: Ten postlingual deaf children, implanted before 18 years of age, participated in this study. We assessed: sentence recognition and speech intelligibility. We documented: device use and function and the patient's academic/occupational status. Study design: series. RESULTS: The mean scores were

  8. HDL and the menopause.

    Science.gov (United States)

    El Khoudary, Samar R

    2017-08-01

    To summarize recent provocative findings on conventional and novel metrics of HDL including HDL-C, HDL subclasses and HDL cholesterol efflux capacity as related to menopause. Pattern of menopause-related changes in HDL-C are not consistent, suggesting a complex relationship between HDL and menopause. Growing body of literature indicates that higher levels of HDL-C may not be consistently cardio-protective in midlife women, suggesting a potential change in other metrics of HDL that could not be captured by the static metric HDL-C. It is also possible that higher HDL-C at certain conditions could be a marker of HDL metabolism dysfunctionality. Significant alterations in other metrics of HDL have been reported after menopause and found to be related to estradiol. The impact of changes in novel metrics of HDL over the menopausal transition on cardiovascular disease (CVD) risk later in life is not clear in women. Much of our understanding of how the menopausal transition may impact HDL metrics comes from cross-sectional studies. Future longitudinal studies are needed to evaluate other metrics of HDL shown to better reflect the cardio-protective capacities of HDL, so that the complex association of menopause, HDL and CVD risk could be characterized.

  9. Efeito da pressão de homogeneização nas propriedades funcionais do leite de soja em pó The effect of homogenization pressure on functional properties of powdered soybean milk

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    Lair C. CABRAL

    1997-12-01

    Full Text Available O leite de soja foi submetido a diferentes pressões (3.000; 4.000; 5.000 e 6.000 psi de homogeneização e em seguida, foi seco por atomização. As propriedades funcionais destes leites de soja em pó foram estudadas. Observou-se que houve melhoria na absorção de gordura, índice de dispersibilidade de proteína, índice de solubilidade de nitrogênio e nas propriedades emulsificantes com o aumento da pressão de homogeneização até 5.000 psi. Os valores numéricos para as propriedades espumantes não foram relevantes, embora as mesmas tenham sido também afetadas pelas diferentes pressões de homogeneização. Recomenda-se, portanto, o leite de soja em pó submetido previamente a homogeneização de 5.000 psi, para o uso em produtos de carne, bebidas, sopas, molhos, produtos de confeitaria e de chocolataria.The functional properties of powdered soybean milks submitted previously a homogenization pressures of 3,000; 4,000; 5,000 and 6,000 psi were studied. It was observed an improvement of fat absorption, protein dispersibility index, nitrogen solubility index and emulsification properties with the increase of homogenization pressure up to 5,000 psi. The value of foaming properties were not relevant, although they were affected by different homogenization pressures. The powdered soybean milk previously subjected to homogenization at 5,000 psi, can be therefore recommended for using in meat, chocolate and confectionary products, beverages, soups and sauces.

  10. Metadados digitais: revisão bibliográfica da evolução e tendências por meio de categorias funcionaisDigital metadata: bibliographical review on evolution and trends using functional categories

    Directory of Open Access Journals (Sweden)

    Luiz Fernando de Barros Campos

    2007-01-01

    Full Text Available Revisão bibliográfica sobre metadados digitais no campo da ciência da informação, objetivando precisar as várias funcionalidades dos metadados. Empregando-se uma técnica de análise de conteúdo temática, constatou-se a recorrência de tecnologias como XML, RDFS, ontologias, data warehouses, Web Semântica, serviços Web, entre outras, e de dez categorias relativas às funções dos metadados que fundamentavam os textos examinados. Com suporte na análise temática, adotando-se uma perspectiva técnica e histórica, relacionaram-se as categorias funcionais às tecnologias e mostrou-se como as categorias são tratadas em dezenove dos artigos revisados, destacando-se as ênfases empregadas e a convergência dos temas. Notou-se que trabalhos e tecnologias que versam sobre padrões e modelos para preservação digital adotam perspectivas mais abrangentes e integradas, incorporando todas ou quase todas as categorias. Com base nos resultados, foram comentadas tendências e questões latentes percebidas na revisão bibliográfica, e sugeridas abordagens e metodologias para a análise de metadados e das tecnologias relacionadas.By means of a bibliographical review on digital metadata in the information science field, aiming to distinguish the various functionalities of metadata and employing thematic content analysis, it was noticed the recurrence of technologies like XML, RDFS, ontology, data warehouses, semantic Web, Web services, among others, and of certain categories connected to metadata functions that grounded the examined works. Based on these findings, adopting a technical and historical approach, the functional categories were related to the technologies and it was showed how the categories wereexpounded in 19 texts selected from the review. It was observed that studies and technologies that deal with models and standards for digital preservation adopt more comprehensive and integrated perspectives, encompassing all or nearly all

  11. Tecnologia de bioprocesso para produção de alimentos funcionais.

    OpenAIRE

    Sousa, Rita de Cássia Pompeu de; Rede de Biodiversidade e Biotecnologia da Amazônia Legal ( BIONORTE), Boa Vista, Roraima, Brasil.; Santos, Daniela Cavalcante dos; Rede de Biodiversidade e Biotecnologia da Amazônia Legal ( BIONORTE), Boa Vista, Roraima.; Neves, Leandro Timoni Buchdid Camargo; Universidade Federal de Roraima/Rede de Biodiversidade e Biotecnologia da Amazônia Legal (BIONORTE).; Chagas, Edvan Alves; Embrapa/Rede de Biodiversidade e Biotecnologia da Amazônia Legal (BIONORTE).

    2013-01-01

    A busca por tecnologias para produção de alimentos com alto valor agregado tem sido alvo de pesquisas nos últimos anos. A tecnologia de bioprocesso para produção de alimentos funcionais é um exemplo. Os alimentos funcionais têm sido definidos como alimentos que, em virtude da presença de componentes fisiologicamente ativos, fornecem benefícios à saúde, além da nutrição básica. Entretanto, devido as diferentes etapas que a compõem, a tecnologia de bioprocessos para produção desses alimentos...

  12. Análise comparativa de nutrientes funcionais em morangos de diferentes cultivares da região de Lavras-MG Comparative analysis of functional nutrients in strawberries of different cultivars in the region of Lavras-MG

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    Denise Alvarenga Rocha

    2008-12-01

    Full Text Available O morango é um pseudofruto muito apreciado pela população brasileira, e seu cultivo vem sendo implantado na região de Lavras. É um alimento funcional, pois, além das suas propriedades nutricionais, também possui substâncias ativas, que mantêm ou melhoram a saúde do organismo humano. O objetivo deste trabalho foi avaliar alguns compostos do morango que tenham efeitos benéficos para a saúde humana, em diferentes cultivares da região de Lavras-MG. O delineamento utilizado foi o inteiramente casualizado, com três tratamentos e 7 repetições de 5 frutos cada. Foram colhidos 150 frutos de três cultivares: 'Aroma', 'Oso grande' e 'Toyorrinho', os quais foram selecionados de acordo com o estádio de maturação e ausência de injúrias. Os compostos avaliados foram vitamina C, compostos fenólicos e minerais, dentre os quais o potássio, cálcio, magnésio, ferro, cobre, manganês e zinco. Entre as três cultivares, a 'Aroma' foi a que mais se destacou em relação à vitamina C e potássio; a cultivar 'Oso grande' obteve os maiores teores de cálcio, ferro, manganês, zinco e cobre, e a 'Toyorrinho' apresentou os menores teores dos compostos funcionais estudados.The strawberry is a pseudo-fruit highly appreciated by the Brazilian population, and its growing has been being established in the region of Lavras. It is a functional food, because in addition to its nutritional properties, it also has active substances, which maintain or improve the health of the human organism. The aim of this work was to evaluate a few compounds of the strawberry, which have beneficial effects to human health in different cultivars of the region of Lavras-MG. It was used the completely randomized design with three treatments and seven replicates of five fruits each. A hundred and fifty fruits from three cultivars, 'Aroma', 'Oso Grande' and 'Toyorrinho' were harvested; those were selected according to the maturation stage and absence of injuries. The

  13. HDL: The "Good" Cholesterol

    Science.gov (United States)

    ... There are two main types of cholesterol: HDL (good) cholesterol and LDL (bad) cholesterol: HDL stands for high-density lipoproteins. It is called the "good" cholesterol because it carries cholesterol from other parts ...

  14. Anatomia da madeira de Sebastiania commersoniana (Baillon Smith & Downs (Euphorbiaceae: aspectos funcionais e ecológicos Wood anatomy of Sebastiania commersoniana (Baillon Smith & Downs (Euphorbiaceae: functional and ecological aspects

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    Nelson Luiz Cosmo

    2010-09-01

    Full Text Available Sebastiania commersoniana é uma espécie arbórea bastante comum em ambientes aluviais, em diversas condições pedológicas, graças a sua plasticidade e capacidade de tolerar períodos de inundação. Foram amostrados 21 indivíduos adultos dessa espécie, na planície do rio Iguaçu, visando à caracterização anatômica da madeira e sua interpretação em termos funcionais. S. commersoniana possui porosidade difusa, vasos solitários e múltiplos de dois a seis, com arranjo radial e placas de perfuração simples. Os vasos são pouco freqüentes (12-16-20/mm², com diâmetro de 54-88-117 µm e elementos de vaso com comprimento 164-602-1025 µm. As fibras libriformes têm 656-1222-2050 µm de comprimento, 10-26-42 µm de largura, e paredes delgadas a espessas (1,0-2,8-5,1 µm. Fibras gelatinosas são freqüentes. Ocorre parênquima apotraqueal difuso em agregados, e paratraqueal escasso. Os raios, unisseriados, têm 164-805-2787 µm de altura e 12-22-35 µm de largura. Células perfuradas de raio são freqüentes, bem como máculas contendo grãos de amido. Estes também ocorrem no parênquima radial e no axial. A espécie desenvolve lenho de tensão em árvores inclinadas. A maioria dos caracteres observados coincide com descrições disponíveis para o gênero e a família a que a espécie pertence. Algumas características qualitativas são discutidas quanto às suas possíveis funções e implicações para a auto-ecologia da espécie.Sebastiania commersoniana is a very common tree species in alluvial environments with diverse soil conditions due to its plasticity and ability to tolerate periods of flooding. In this study we sampled 21 adult individuals of this species on the Iguaçu River plain, for wood anatomy characterization and interpretation using a functional approach. S. commersoniana has diffuse porous, solitary vessels and multiples of two to six, radially arranged with simple perforation plates; low vessel frequency (12

  15. Revisão: Composição química, propriedades funcionais e aplicações tecnológicas da semente de chia (Salvia hispanica L) em alimentos

    OpenAIRE

    Coelho, Michele Silveira; Salas-Mellado, Myriam de Las Mercedes

    2014-01-01

    A chia (Salvia hispanica L.) é uma semente antiga utilizada pelos maias e astecas como alimento para aumentar a resistência física. Essa semente é fonte natural de ácidos graxos ômega-3, fibras e proteínas, além de outros componentes nutricionais importantes, como os antioxidantes. Além disso, oferece um potencial na indústria de alimentos devido aos seus componentes funcionais, com aplicações no enriquecimento de pães, bolos e barras de cereais, produção de hidrolisados proteicos para aplica...

  16. Proteína oligomérica da matriz cartilaginosa/trombospondina 5(COMP/TSP-5) como biomarcador em diferentes estágios funcionais da artrite reumatóide

    OpenAIRE

    Andrade, Fernanda Duarte de

    2008-01-01

    Introdução: A artrite reumatóide (AR) é o exemplo clássico de artropatia crônica erosiva. É uma doença potencialmente severa e incapacitante. Seu curso e sua progressão são bastante variáveis. A proteína oligomérica da matriz cartilaginosa/trombospondina-5 (COMP/TSP-5) é considerada um potencial biomarcador de prognóstico na AR. Não há, entretanto, estudos detalhados acerca da associação entre grau funcional da AR e níveis séricos de COMP/TSP-5. Objetivo: Avaliar os níveis séricos de COMP/TSP...

  17. Conhecimento da comunidade universitária em relação aos alimentos funcionais - doi: 10.4025/actascihealthsci.v35i1.10134 Knowledge of the academic community in relation to the functional foods - doi: 10.4025/actascihealthsci.v35i1.10134

    Directory of Open Access Journals (Sweden)

    Márcia Portilho

    2013-03-01

    Full Text Available Alimentos funcionais apresentam componentes fisiologicamente ativos, capazes de promover a saúde, além dos benefícios nutricionais. A uva e seus derivados, por apresentar compostos com alto potencial bioativo, especialmente o resveratrol, foram escolhidos como objeto de pesquisa na avaliação do conhecimento do consumidor em relação aos alimentos funcionais. A população de estudo escolhida foi a comunidade de três instituições universitárias da cidade de Maringá, Estado do Paraná. Foi elaborado um questionário e aplicado a um total de 485 indivíduos. O alimento mais aceito e mais consumido foi o suco de uva (51% de aceitação, seguido do vinho tinto (49% de aceitação. A bebida de soja sabor uva, alimento que apresentou menor popularidade, nunca foi experimentada por 13% da população entrevistada e 40% nunca consomem este alimento. Dos entrevistados, 48% pareceram desconhecer ou não estar certos das alegações de saúde propostas no questionário. Tal desconhecimento refere-se à relação do vinho e compostos fenólicos com efeitos sobre a pressão arterial, osteoporose, diurese e antidepressão. Apesar do interesse e curiosidade quanto aos alimentos funcionais, os jovens entrevistados ainda não têm conhecimento suficiente sobre os benefícios dos alimentos funcionais à saúde humana.  Functional foods have physiologically active components capable of promoting health, and nutritional benefits. The grape and its derivatives, due to the compounds with high bioactive potential, especially resveratrol, were chosen as a research subject in the assessment of consumer knowledge regarding functional foods. The study population was the community of three universities in the city of Maringá, Paraná State. A questionnaire was developed and applied to a total of 485 individuals. The food most accepted and consumed was grape juice (51% acceptance, followed by red wine (49% acceptance. The soy drink grape-flavored, food with the

  18. Efeito da hidrólise enzimática sobre propriedades funcionais de caseína bovina coagulada pela ação da quimosina Effect of enzimatic hydrolysis on functional properties of bovine casein coagulated by the action of chymosin

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    Janesca Alban Roman

    2005-09-01

    Full Text Available Este trabalho teve como objetivo verificar a influência do grau de hidrólise sobre as propriedades funcionais hidrofílicas (capacidade de absorção espontânea de água-CAA, capacidade de retenção de água-CRA e solubilidade da proteína-SP e de superfície (capacidade de formação e estabilização de espumas e de emulsões da caseína bovina obtida por coagulação enzimática. Os graus de hidrólise (GH estudados foram: 5,7; 12,8; 20,1 e 35,8%. Observou-se que quanto maior o GH maior a SP e menor a CRA dos hidrolisados. A hidrólise enzimática melhorou a capacidade de formação de espuma, pois o coágulo de caseína (COC não formou espuma nas condições estudadas. A melhor capacidade de formação de espuma foi conseguida com o GH 12,8% e a maior estabilidade com GH 5,7%. Os hidrolisados, com GH 12,8; 20,1 e 35,8% não formaram emulsão. Não houve diferenças significativas entre o GH 5,7% e o COC quanto à formação de emulsão, mas a estabilidade da emulsão do hidrolisado de menor grau de hidrólise foi significativamente superior ao coágulo de caseína.The objective of the present work was to study the influence of degree of hydrolysis (DH on the hydrophilic and surface functional properties of a bovine casein obtained by enzymatic coagulation (COC. The degrees of hydrolysis produced were 5.7, 12.8, 20.1 and 35.8%. It was observed that the higher the DH, the higher the protein solubility and the lower the water retention capacity (WRC of the hydrolysates. The best foaming capacity was obtained with 12.8% DH and best foam stability with 5.7% DH. The hydrolysate with 5.7% DH showed the same emulsifying capacity as the coagulated casein, however emulsion stability was superior for the 5.7% hydrolysate than for COC. The hydrolysates with higher DH (12.8, 20.1 and 35.8% did not form emulsion.

  19. Componentes funcionais da teoria de Peplau e sua confluência com o referencial de grupo Componentes funcionales de la teoría de Peplau y su confluencia con el referencial de grupo Analysis of the Functional components of the Peplau's theory and its confluence with the group reference

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    Leila Memória Paiva Moraes

    2006-06-01

    Full Text Available As teorias de enfermagem precisam ser analisadas para que possamos acessar o real significado das idéias explicitadas pelas teóricas e, com isso, possibilitar que os enfermeiros as considerem e as incorporem na prática profissional. Este estudo objetivou analisar os componentes funcionais da teoria de Hildegard Elizabeth Peplau, com base no modelo proposto por Meleis e sua confluência com o referencial de grupo utilizado no trabalho com dependentes químicos. A construção deste estudo proporcionou, não apenas conhecer os componentes funcionais desta teoria, onde os mesmos foram identificados, mas, principalmente, sua adequação e utilização a grupos no âmbito da cotidianidade da prática de cuidar do dependente químico.Las teorías de enfermería necesitan ser analizadas para que podamos acceder al real significado de las ideas explicitadas por las teóricas y, con eso, posibilitar que los enfermeros las consideren e incorporen en su práctica profesional. Este estudio tuvo como objetivo analizar los componentes funcionales de la teoría de Hildegard Elizabeth Peplau, con base en el modelo propuesto por Meleis y su confluencia con el referencial de grupo utilizado en el trabajo con dependientes químicos. La construcción de este estudio permitió, no sólo conocer los componentes funcionales de esta teoría, donde los mismos fueron identificados, sino, principalmente, su adecuación y utilización a grupos en el ámbito cotidiano de la práctica de cuidar del dependiente químico.To facilitate nurses' application of nursing theories, theories must be analyzed and disseminated. This study aimed to analyze the functional components of Paplau's Theory of Nursing among chemical dependent participants. The analysis of the theory was based on Meleis's model. The results of this analysis provided more than an understanding of the functional components of this theory; the results included the appropriateness and utilization of Paplau

  20. Revisão: Composição química, propriedades funcionais e aplicações tecnológicas da semente de chia (Salvia hispanica L em alimentos

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    Michele Silveira Coelho

    2014-12-01

    Full Text Available A chia (Salvia hispanica L. é uma semente antiga utilizada pelos maias e astecas como alimento para aumentar a resistência física. Essa semente é fonte natural de ácidos graxos ômega-3, fibras e proteínas, além de outros componentes nutricionais importantes, como os antioxidantes. Além disso, oferece um potencial na indústria de alimentos devido aos seus componentes funcionais, com aplicações no enriquecimento de pães, bolos e barras de cereais, produção de hidrolisados proteicos para aplicação em produtos de panificação, produção de maionese com adição de mucilagem de chia, entre outros produtos. Esta revisão tem como objetivo apresentar as possíveis aplicações em alimentos, demonstrando o quanto a chia ainda pode ser explorada nessa área.

  1. Propriedades funcionais (tecnológicas da parede celular de leveduras da fermentação alcoólica e das frações glicana, manana e glicoproteína Functional (technological properties of yeast cellular wall of alcoholic fermentation and its glycan, mannan, and glycoprotein fractions

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    Saula Goulart Chaud

    2006-06-01

    Full Text Available Foram objetivos do presente trabalho o fracionamento, a caracterização química e o estudo das propriedades funcionais (tecnológicas da fração parede celular (PC de leveduras da fermentação alcóolica e das subfrações glicana, manana e glicoproteína. O fracionamento foi realizado por processos físico-químicos de extração, centrifugação e secagem em spray dryer, a caracterização química pela determinação da composição centesimal e as propriedades funcionais pelo uso de técnicas apropriadas. Os componentes predominantes da parede celular (PC foram proteína (19% e fibra solúvel (74%, da fração glicoproteina, foram as proteínas (35,5% e fibra solúvel (56%, nas frações manana (M e glicana solúvel (GS predominaram as fibras solúveis (~70% e na fração glicana insolúvel (GI, as fibras insolúveis (70,7%. A solubilidade das várias frações em meio aquoso não mostrou dependência do pH e variou entre 40% e 100%. A fração que apresentou maior capacidade de retenção de água (CRA foi a glicana solúvel (14,4 g H2O/g de amostra e os maiores índices de solubilidade em água (ISA foram os das frações glicoproteina (83,8% e manana (60%. As frações glicana (GS e GI apresentaram boas propriedades de geleificação nas concentrações de 12 e 14% de sólidos solúveis. As frações glicoproteína, manana e glicana solúvel apresentaram excelente capacidade de emulsificação (1.500 a 2.000 mL óleo/g amostra e as emulsões de glicoproteína e glicana solúvel foram as mais estáveis. Adição de igual concentração (0,2% de ovalbumina aumentou significativamente o poder de emulsificação das frações PC e GS e contribuiu para a estabilidade das emulsões da manana e da glicoproteína (M e GP.The objectives of the present work were the fractionation, the chemical characterization and the study of functional (technological properties of the cell wall (CW of yeast from alcohol fermentation and the subfractions

  2. Influência da extensão da artrodese lombossacra nos resultados clínicos e funcionais Influencia de la extensión de la artrodesis lumbosacra en los resultados clínicos y funcionales Influence of the extent of lumbosacral arthrodesis in clinical and functional outcomes

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    Alberto Ofenhejm Gotfryd

    2012-01-01

    Full Text Available OBJETIVO: Verificar a influência da extensão da fusão póstero-lateral lombossacra e seu impacto nos resultados clínicos e funcionais. MÉTODOS: Foram avaliados 22 pacientes portadores de estenose central, foraminal ou hérnia de disco lombar, associadas a instabilidade segmentar, submetidos ao tratamento cirúrgico para a descompressão neural e artrodese póstero-lateral. Os pacientes foram divididos em dois grupos, de acordo com quantidade de níveis artrodesados: Grupo 1: fusão em um nível e Grupo 2: fusão em dois ou mais níveis. Os pacientes preencheram questionários referentes ao acompanhamento pós-operatório (uso de medicamentos analgésicos e satisfação com o tratamento e escala analógica visual de dor lombar e ciática. Além disto, foram aplicados os questionários Oswestry e SF-36 para avaliação da qualidade de vida. RESULTADOS: Os resultados do SF-36 mostraram bons níveis de qualidade de vida em ambos os grupos, com exceção do domínio "Aspectos Físicos". Não houve correlação significativa entre a extensão da artrodese e os desfechos clínicos. CONCLUSÕES: Os pacientes submetidos à artrodese póstero-lateral apresentaram qualidade de vida satisfatória, exceto pela diminuição da aptidão física. Entretanto, o maior número de níveis artrodesados não teve impacto negativo sobre os aspectos clínicos e funcionais.OBJETIVO: Investigar la influencia del grado de la fusión posterolateral lumbosacral y su impacto en los resultados clínicos y funcionales. MÉTODOS: Se evaluaron 22 pacientes con estenosis central, foraminal o hernia de disco lumbar, asociadas a inestabilidad segmentaria; se sometieron a cirugía para la descompresión neural y la artrodesis posterolateral. Los pacientes fueron divididos en dos grupos según el número de niveles fusionados: Grupo 1: la fusión en un nivel, y Grupo 2: la fusión en dos o más niveles. Los pacientes completaron cuestionarios sobre seguimiento posoperatorio (uso

  3. Genetic determinants of HDL metabolism.

    Science.gov (United States)

    Ossoli, A; Gomaraschi, M; Franceschini, G; Calabresi, L

    2014-01-01

    Plasma high density lipoproteins (HDL) comprise a highly heterogeneous family of lipoprotein particles, with subclasses that can be separated and identified according to density, size, surface charge as well as shape and protein composition. There is evidence that these subclasses may differ in their functional properties. The individual plasma HDL cholesterol (HDL-C) level is generally taken as a snapshot of the steady-state concentration of all circulating HDL subclasses together, but this is insufficient to capture the structural and functional variation in HDL particles. HDL are continuously remodeled and metabolized in plasma and interstitial fluids, through the interaction with a large number of factors, including structural proteins, membrane transporters, enzymes, transfer proteins and receptors. Genetic variation in these factors can lead to essential changes in plasma HDL levels, and to remarkable changes in HDL particle density, size, surface charge, shape, and composition in lipids and apolipoproteins. This review discusses the impact of rare mutations and common variants in genes encoding factors involved in HDL remodeling and metabolism on plasma HDL-C levels and particle distribution. The study of the effects of human genetic variation in major players in HDL metabolism provides important clues on how individual factors modulate the formation, maturation, remodeling and catabolism of HDL.

  4. Videolaparoscopic cholecystectomy. Analysis of the clinical and functional aspects of mechanical lifting of the abdominal wall Colecistectomia videolaparoscópica. Análise de aspectos clínicos e funcionais da suspensão mecânica da parede abdominal

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    Marco Aurelio SANTO

    2001-01-01

    . Depending on the position of the epigastric trocar, the lifting equipment can interfere with the surgical instruments mobility. It may be necessary to reposition the support to perform the intra-operative cholangiography. The tensional force applied to the peritoneal surface by the lifting rods is small, and no additional post-operative pain was observed using this procedure. Conclusion - These results show that using the equipment described in this study, mechanical lifting of the abdominal wall is a feasible alternative for undertaking videolaparoscopic cholecystectomy.Racional - A suspensão mecânica da parede abdominal, método baseado no mecanismo de tração e conseqüente elevação da parede abdominal, é procedimento alternativo para a criação de adequado espaço intra-abdominal necessário à cirurgia videolaparoscópica, prescindindo-se da insuflação gasosa intra-peritonial. Objetivo - Avaliar a viabilidade técnica desse procedimento para realização da colecistectomia videolaparoscópica, com a análise de aspectos clínicos e funcionais da suspensão mecânica da parede abdominal. Pacientes e Métodos - Na Disciplina de Cirurgia do Aparelho Digestivo da Faculdade de Medicina da Universidade de São Paulo foi criado equipamento para realização de cirurgia videolaparoscópica por esse método, constituído de duas partes: a externa consiste em um pórtico acoplado à mesa operatória, no interior do qual desliza um cabo de aço que é tracionado por um sistema de catraca presente na extremidade inferior de uma das hastes do pórtico; a interna, o dispositivo suspensor, tem o formato em "L", cujo ramo horizontal é constituído de três hastes giratórias, o qual é conectado ao cabo de aço após introdução na cavidade abdominal. Com esse equipamento 10 pacientes foram submetidos a colecistectomia videolaparoscópica; em um deles foi associada hiatoplastia e fundoplicatura. Foram avaliados o tempo de instalação do equipamento, as características do

  5. Formação de classes funcionais de estímulos musicais

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    Alex Roberto Machado

    2009-04-01

    Full Text Available O objetivo deste experimento foi verificar o efeito do treino discriminativo sobre a formação de classes funcionais de melodias em andamentos e modos diferentes. Nove estudantes universitários do 2° período da graduação em Psicologia foram divididos em três grupos: Modo, Andamento ou Misto. O software SomPsi, produzido especialmente para este estudo, treinou os participantes e gerou relatórios com informações sobre os desempenhos, nas quatro fases do procedimento. O treino proposto mostrou-se eficiente para a formação das classes funcionais de estímulos sonoros musicais. Observou-se que agrupamentos de estímulos pela propriedade andamento foram mais facilmente discriminados que os agrupados pela melodia. A manipulação combinada das duas propriedades, em condição convergente, permitiu desempenho superior dos participantes. A rápida formação de classes funcionais e equivalentes de estímulos musicais, a partir de procedimentos de ensino automatizado de relações condicionais entre estímulos musicais, indica a possibilidade de uso desse procedimento na iniciação à música.

  6. Categorias funcionais e conhecimento enciclopédico ou sintaxe e significado no domínio verbal: noções aspectuais e expressão da causatividade em Ticuna

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    Marília Facó Soares

    2012-11-01

    Full Text Available Focalizando detidamente o domínio verbal e as categorias funcionaisaí postuladas, este artigo possui os seguintes objetivos: aprofundar oexame de aspectos da morfologia verbal do Ticuna – língua tonal,geneticamente isolada e falada na Amazônia; comprovar o quanto certosaspectos do significado são aí determinados pela sintaxe; e verificarquais propostas, entre aquelas formuladas para categorias funcionaisno domínio verbal, se encontram apoiadas pelos fatos da língua estudada.O exame efetuado se dá em relação a determinados sufixos aspectuaisabrigados no verbo Ticuna e em relação à expressão da causatividadenessa língua. Para alcançar seus objetivos, o artigo retraçatematicamente o percurso teórico da categoria funcional pequeno verboou v-zinho, considerando desdobramentos e consequências comrelação aos pontos que se tornaram parte de sua caracterização. Asconclusões alcançadas reafirmam que os aspectos do significadodeterminados pela sintaxe excluem o agente externo e indicam que,no que diz respeito ao causativo, o tipo de complemento selecionadopor esse é fundamental para a constituição de uma expressão idiomática.A análise realizada apoia o caráter verbalizador de v-zinho, a dissociaçãoentre as propriedades da transitividade e as propriedades semânticasdessa categoria (ARAD, 1999 – essencial para o tratamento desufixos aspectuais na língua estudada. No âmbito da causatividade,a fragmentação de v-zinho em diferentes tipos, necessita, porém, levarem consideração a possibilidade da separação formal entre Voz e Causa(PYLKKÄNEN, 2002.

  7. The effect of functional limitations and fatigue on the quality of life in people with multiple sclerosis O efeito das limitações funcionais e da fadiga na qualidade de vida de indivíduos com esclerose múltipla

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    Leandro Alberto Calazans Nogueira

    2009-09-01

    Full Text Available The purpose of this study was to determine the effect of functional limitations and fatigue on the quality of life (QoL in people with multiple sclerosis (MS. A descriptive case series study at Lagoa Hospital - Rio de Janeiro, Brazil was carried. The main outcome measurements were demographic variables, QoL (SF-36 v.1, disability (EDSS, motor function of the upper limb (Box & Blocks test, Tone (Modified Ashworth Scale, gait (Hauser ambulatory index and fatigue (Fatigue Severity Scale. Sixty one patients fulfilled the study criteria. The mean age of patients was 39 years and 74% of patients were female. The most of cases presented mild disability (EDSSO objetivo do estudo foi determinar o efeito das limitações funcionais e da fadiga na qualidade de vida (qv de indivíduos com esclerose múltipla (em. foi conduzido um estudo descritivo de série de casos no Hospital da Lagoa - Rio de Janeiro, Brasil. As principais medidas utilizadas foram as variáveis demográficas, QV (SF-36 v.1, incapacidade (EDSS, função motora da extremidade superior (Teste da Caixa e Blocos, Tônus (Escala Modificada de Ashworth, marcha (Índice Ambulatorial de Hauser e fadiga (Escala de Severidade de Fadiga. Sessenta e um pacientes preencheram os critérios do estudo. A média de idade foi de 39 anos e 74% dos pacientes eram do gênero feminino. A maioria dos casos apresentou incapacidade leve (EDSS<3,5. Foi encontrada uma diminuição em todas dimensões da QV. Foi observada uma associação entre a função física e as variáveis EDSS, fadiga, tônus dos membros inferiores e marcha. Marcha, incapacidade, hipertonia dos membros inferiores e fadiga afetam negativamente a QV de indivíduos com EM.

  8. to HDL-cholesterol functionality

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    Malara Marzena

    2016-05-01

    Full Text Available The purpose of this study was to analyse the scientific evidence concerning the effects of two enzymes – paraoxonase 1 and myeloperoxidase – on the functions of HDL-cholesterol. It is well documented that disturbed circulating lipoproteins (a high total and high LDL-cholesterol, and low HDL-cholesterol bring about atherosclerosis and an increased risk of cardiovascular disease (CVD which is recognised as the main cause of death all around the world. In consequence, numerous studies have focused on procedures which will improve the plasma lipoproteins profile by decreasing the total cholesterol and the LDL-cholesterol (LDL-C and increasing the HDL-cholesterol (HDL-C. However, the anti-atherogenic role of HDL-C has been challenged in studies showing that genetically elevated HDL-cholesterol does not offer protection against CVD. Moreover, it has been found that raising the circulating HDL-cholesterol fails to reduce atherosclerosis. The doubts concerning the protective role of HDL-C have been supported by in vitro studies which indicate that the HDL-C from patients with atherosclerosis does not have a protective action, but does stimulate inflammation and free radical synthesis. The above data suggests that HDL-C, commonly recognised as protective against atherosclerosis, in some circumstances becomes pro-atherogenic, and is thus dysfunctional. Our review focuses on two enzymes – paraoxonase 1 (PON1 and myeloperoxidase (MPO – which markedly affect the properties of HDL-C and contribute to its anti – or pro-atherogenic activity. Moreover, the effects of the diet and physical activity on PON1 and MPO are summarised with respect to the HDL-C functionality.

  9. Estudo comparativo das variáveis funcionais em jovens praticantes e não praticantes, em função da idade relativa e do ano de nascimento

    OpenAIRE

    Machado, Rui Miguel Fernandes Teixeira

    2016-01-01

    Dissertação de Mestrado em Ensino de Educação Física, no Ensinos Básico e Secundário Esta tese de mestrado está inserida no âmbito do 2º Ciclo de estudos da Universidade de Trás-os-Montes e Alto Douro, nomeadamente no Mestrado em Ensino da Educação Física nos Ensinos Básico e Secundário. Ao longo desta tese falo de todos os processos que estiveram inerentes ao meu estágio realizado no Agrupamento de Escolas de Ribeira de Pena durante o ano letivo 2014/2015. Tem como foco principal todos...

  10. Raising HDL cholesterol in women

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    Danny J Eapen

    2009-11-01

    Full Text Available Danny J Eapen1, Girish L Kalra1, Luay Rifai1, Christina A Eapen2, Nadya Merchant1, Bobby V Khan11Emory University School of Medicine, Atlanta, GA, USA; 2University of South Florida School of Medicine, Tampa, FL, USAAbstract: High-density lipoprotein cholesterol (HDL-C concentration is essential in the determination of coronary heart disease (CHD risk in women. This is especially true in the postmenopausal state, where lipid profiles and CHD risk mimic that of age-matched men. Thus, interventions designed to reduce CHD risk by raising HDL-C levels may have particular significance during the transition to menopause. This review discusses HDL-C-raising therapies and the role of HDL in the primary prevention of CHD in women. Lifestyle-based interventions such as dietary change, aerobic exercise regimens, and smoking cessation are initial steps that are effective in raising HDL-C, and available data suggest women respond similarly to men with these interventions. When combined with pharmacotherapy, the effects of these lifestyle alterations are further amplified. Though studies demonstrating gender-specific differences in therapy are limited, niacin continues to be the most effective agent in raising HDL-C levels, especially when used in combination with fibrate or statin therapy. Emerging treatments such as HDL mimetic therapy show much promise in further raising HDL-C levels and improving cardiovascular outcomes.Keywords: high-density lipoprotein, HDL, women, cholesterol, heart disease

  11. Influência do pré-tratamento com ultra-som e da secagem nas propriedades químicas, físicas e funcionais do amido de banana verde

    OpenAIRE

    Izidoro, Dayane Rosalyn

    2011-01-01

    Resumo: A produção brasileira de banana, confere ao país o lugar de quarto maior produtor mundial, sendo que elevadas perdas desde a colheita até a comercialização salientam a necessidade de se desenvolver tecnologias para melhor aplicação da fruta. A banana verde, possui elevado teor de amido com propriedades peculiares que podem ser de grande interesse industrial. Alterações na estrutura do amido visando estender a aplicabilidade, contribuíram para crescimento das técnicas de modificação. O...

  12. Resultados clínicos e funcionais da cirurgia de reconstrução do LCA contralateral em médio prazo - doi: 10.5102/ucs.v11i1.1962

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    Gabriela Ataides

    2013-07-01

    Full Text Available Lesões na articulação do joelho têm grande impacto na vida das pessoas devido à sua alta prevalência e sua repercussão clínica. Estudos comprovam a eficácia da cirurgia e do tratamento em curto prazo utilizando o tendão contralateral como enxerto. O presente estudo é do tipo transversal e tem como objetivo analisar a condição de pacientes que foram submetidos à cirurgia com enxerto contralateral e reabilitação do Ligamento Cruzado Anterior (LCA após um período de 3 a 10 anos. Foram avaliados vinte e dois (n=22 pacientes, selecionados aleatoriamente por meio de um banco de dados. Nos resultados encontrados, observou-se alteração apenas no Single Leg Hop Test (p-valor= 0,003 e Pico de Torque (PT de extensão a 60°/s e 180°/s (0,00 e 0,04. Nos parâmetros de estado clínico, os resultados obtidos foram benéficos. Portanto, o tratamento com o enxerto do tendão patelar contralateral apresentou bons resultados, visto que houve melhora da condição clínica esperada ao longo desses anos.

  13. Aspectos funcionais, microbiológicos e morfológicos intestinais em crianças infectadas pelo vírus da imunodeficiência humana Functional, microbiological and morphological intestinal findings among human immunodeficiency virus infected children

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    Christiane Araujo Chaves Leite

    2006-12-01

    Full Text Available RACIONAL: O trato gastrointestinal é freqüentemente acometido nas crianças infectadas pelo vírus da imunodeficiência humana, com importantes repercussões no seu estado nutricional e sobrevida. A maioria dos estudos relacionados a esse tema foi desenvolvida com adultos, sendo menos investigado o problema nas crianças OBJETIVOS: Estudar aspectos digestivo-absortivos, microbiológicos e morfológicos intestinais em crianças infectadas pelo vírus da imunodeficiência humana MATERIAL E MÉTODOS: Onze crianças infectadas pelo vírus da imunodeficiência humana, menores de 13 anos, pertencentes às categorias clínicas A, B ou C, divididas em dois grupos: cinco pacientes com relato atual ou recente de diarréia e seis pacientes sem diarréia nos 30 dias que antecederam à inclusão no estudo. Investigação proposta: biopsia de intestino delgado e reto para análise morfológica e microbiológica, coprocultura, protoparasitológico de fezes, pesquisa de rotavírus, micobactérias e Cryptosporidium; teste da D-xilose RESULTADOS: Todos os pacientes testados (9/11 apresentavam má absorção da D-xilose (8,4-24,4 mg/dL. Os achados histopatológicos de intestino delgado foram inespecíficos, representados em sua maioria, por enteropatia grau I a II (6/10. Em todos os casos foi constatado aumento do infiltrado celular do córion. As alterações histopatológicas do reto também foram inespecíficas, com presença de aumento do infiltrado celular do córion. A pesquisa de microorganismos enteropatogênicos só foi positiva em dois casos, sendo identificado Mycobacterium avium intracellulare e Cryptosporidium nas fezes CONCLUSÕES: Demonstrou-se alta prevalência (100% de má absorção intestinal em crianças infectadas pelo vírus da imunodeficiência humana, com ou sem diarréia. Não foi possível estabelecer correlações quanto à presença de agentes enteropatogênicos, má absorção intestinal, alterações morfológicas intestinais e

  14. Influência do tratamento térmico e da acidez no comportamento reológico de amidos nativos funcionais de milho cerosos orgânicos comerciais Heat treatment and acidity influence on the rheological behavior of commercial organic waxy corn starch

    Directory of Open Access Journals (Sweden)

    Lizielle Maria Ricardo Guerreiro

    2009-06-01

    Full Text Available Os amidos são amplamente utilizados em alimentos como molhos para salada, molhos e pratos prontos. Entretanto, as propriedades funcionais de amidos nativos não resistem aos processos estressantes tais como tratamento térmico, acidez e alto cisalhamento. Os amidos podem ser modificados quimicamente neste sentido, mas não atribuem ao alimento o rótulo de "natural". Uma outra opção é obter amidos naturais resistentes às condições de estresse. O objetivo do presente trabalho foi a avaliação de dois amidos que se comercializam rotulados como nativos e orgânicos frente ao tratamento térmico e à acidez. Suspensões dos amidos nativos funcionais orgânicos (9460 e 9560, National Starch and Chemical Industrial preparadas numa concentração de 5% (peso/volume, foram acidificadas com ácido cítrico 1M ou autoclavadas a 121 °C por 30 minutos. O resultado dos tratamentos foi avaliado por microscopia óptica, pelas curvas de escoamento e pelos espectros mecânicos, obtidos por reologia estacionária e dinâmica. A acidez e o tratamento térmico aumentaram a estruturação dos géis dos amidos, que resistiram aos processos estressantes. Os géis apresentaram comportamento não newtoniano, (pseudoplástico e tixotrópico. O comportamento pode ser modelado pela equação Lei da Potência ou Herschel-Bukley. Todos os géis apresentaram comportamento viscoelástico de gel fraco que foi preservado nos diversos tratamentos.Starches are widely utilized in foodstuffs as salad dressing, sauce, and processed foods. However, the functional properties of native starches are affected by processes such as heat treatment, acidity, and high shear stress. Starches can be modified chemically in order to have characteristics required by industries, but not to attribute the food a "natural and safe" label. Another option is to obtain native starches resistant to food processing stress conditions. The objective of this paper is the evaluation of commercial

  15. Determination of the chemical composition and functional properties of shrimp waste protein concentrate and lyophilized flour Determinação da composição química e das propriedades funcionais de concentrado protéico e de farinha liofilizada de resíduos de camarão

    Directory of Open Access Journals (Sweden)

    Olivaldo Lacerda Brasileiro

    2012-04-01

    Full Text Available Wastes from the seafood industry can be easily processed into products with new forms of use. The present study was aimed at determining the chemical composition and functional properties of shrimp waste protein concentrate and lyophilized flour. The raw material used in this study consisted of waste (head of Litopenaeus vannamei. The protein concentrate was obtained by ethanolic extraction, being subsequently submitted to drying in oven at 70° C, while the flour was obtained by lyophilization of shrimp wastes. Moisture, ash, protein and calcium contents showed significant difference between fresh shrimp head waste samples (IN and protein concentrate and lyophilized flour samples. The protein content for protein concentrate (PC and lyophilized flour (LF showed significant increase in relation to protein content in the waste (IN, thus showing that the process for obtaining the protein concentrate was efficient.Resíduos provenientes da indústria do pescado podem ser facilmente transformados em produtos com novas formas de aproveitamento. No presente estudo, objetivou-se determinar a composição química e as propriedades funcionais de farinha liofilizada e concentrado proteico provenientes de resíduos de camarão. A matéria-prima empregada neste estudo foi constituída de resíduos (cabeça de camarão Litopenaeus vannamei. O concentrado proteico foi obtido por extração etanólica e, posteriormente, submetido à secagem em estufa a 70° C, enquanto a farinha foi obtida pelo processo de liofilização do resíduo. Os teores de umidade, cinzas, proteínas e cálcio apresentaram diferença significativa entre as amostras de resíduo de cabeça de camarão in natura (IN e as amostras de concentrado proteico e farinha liofilizada. O teor de proteínas para concentrado protéico (CP e para a farinha liofilizada (FL apresentou aumento significativo em relação ao teor proteico do resíduo (IN, mostrando, assim, que o processo de elaboração do

  16. Atributos de credibilidade e de confiança valorizados pelos consumidores de produtos lácteos funcionais do estado do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Rodrigo de Carvalho Leite

    2013-06-01

    Full Text Available Nesta pesquisa procurou-se identificar as principais fontes de informação e os atributos de credibilidade e de confiança mais valorizados pelos consumidores de produtos lácteos funcionais do Rio Grande do Sul. Uma survey via internet foi realizada no estado com 423 consumidores. A amostra representa, predominantemente, consumidores do sexo feminino (57,9%, com idade entre 25-44 anos (68,6%, com renda familiar entre 3-10 salários mínimos (48%, com ensino superior (29,8% ou com pós-graduação (70,2%. Os dados obtidos indicam que os familiares e os médicos e nutricionistas representam os principais grupos de referência para que o consumidor atribua credibilidade e desenvolva confiança sobre os produtos lácteos funcionais. Além disso, tanto a tradição da empresa (e das suas marcas, a "qualidade da embalagem", como a certificação de órgão oficial representam fatores pertinentes na formação da confiança/credibilidade dos benefícios acessados pelo consumo de lácteos funcionais. Finalmente, os resultados indicam que os consumidores utilizam, preponderantemente, os rótulos dos produtos para se manterem informado sobre as características e benefícios dos alimentos funcionais.

  17. Composição nutricional e propriedades funcionais do murici (Byrsomina crassifolia) e moringa (Moringa Oleifera)

    OpenAIRE

    Érica Sayuri Siguemoto

    2013-01-01

    Introdução - Algumas espécies vegetais comestíveis, mas ausentes na dieta do brasileiro, podem ser boas fontes de nutrientes e de compostos bioativos, e a falta ou a perda de conhecimento sobre elas desfavorece sua inclusão na dieta. Objetivo - Avaliar a composição nutricional e propriedades funcionais da farinha de folha de moringa (Moringa oleifera) e da polpa de murici (Byrsonima crassifolia). Metodologia Os frutos de murici foram coletados em três cidades diferentes do Pará. A fari...

  18. Atividade eletromiográfica do vasto medial oblíquo e vasto lateral durante atividades funcionais em sujeitos com síndrome da dor patelofemural Electromyographic activity of vastus medialis obliquus and vastus lateralis muscles during functional activities in subjects with patellofemoral pain syndrome

    Directory of Open Access Journals (Sweden)

    EP Santos

    2008-08-01

    Full Text Available OBJETIVO: O propósito deste estudo foi avaliar a amplitude e o tempo de ativação elétrica do vasto medial oblíquo (VMO, vasto lateral longo (VLL e vasto lateral oblíquo (VLO durante atividades funcionais em portadoras da síndrome da dor patelofemural (SDPF. MÉTODOS: Participaram do estudo 20 mulheres, sendo dez do grupo controle e dez do grupo com SDPF. O sinal eletromiográfico do quadríceps foi detectado por eletrodos ativos diferenciais simples de superfície e um eletromiógrafo de quatro canais, durante atividades em cadeia cinética aberta (em um dinamômetro isocinético e fechada (através de um step e durante o agachamento. Na análise estatística foram utilizados o teste t de student e uma análise de variância (ANOVA, com método pos-hoc de Tukey, com nível de significância de pOBJECTIVE: The purpose of this study was to evaluate the amplitude and onset of electrical activation of the vastus medialis obliquus (VMO, vastus lateralis longus (VLL and vastus lateralis obliquus (VLO during functional activities in individuals with patellofemoral pain syndrome (PFPS. METHODS: Twenty women participated in the study: ten in a control group and ten in the group with PFPS. The electromyographic signal of the quadriceps muscle was detected using simple active differential surface electrodes and a four-channel electromyography system, during open kinetic chain activities (using an isokinetic dynamometer and closed kinetic chain activities (step and squat maneuvers. For the statistical analysis, Student's t test and ANOVA with Tukey's post-hoc method were used, with a significance level of p<0.05. RESULTS: The results suggested that the electrical activation of the VMO was less intense than in the VLO (p=0.04 and that there was greater delay in VMO onset (p=0.0023 in the group with PFPS, with regard to all of the functional activities evaluated. There was a significant difference between the VMO and VLO in relation to the activities

  19. “Avaliação da qualidade de vida e peak flow nasal em pós-operatório de cirurgias funcionais (turbinectomia e/ou septoplastia em pacientes com obstrução nasal crônica"

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    Filipe Braz

    2015-10-01

    Full Text Available A prevalência da obstrução nasal vem crescendo nos últimos anos. A obstrução nasal tem como causa etiológica uma série de patologias as mais comuns são: polipose nasal, rinossinusites, doenças metabólicas, defeito septal, corpos estranhos, tumores.   Pacientes que sofrem de obstrução nasal além de possuírem os sintomas clássicos de coriza, distúrbios do olfato, apresentam também uma perda significativa na qualidade de vida, uma vez que a acarreta alterações nas atividades cotidianas como: insônia e ronco noturno e apneia, dificuldade na prática de exercício físico.     O trabalho visa mensurar o quanto as cirurgias funcionais nasais melhoram a qualidade de vida e a permeabilidade das vias aéreas superiores de pacientes com obstrução nasal, e se a melhora é apenas no pós operatório imediato ou se essa é a longo prazo.   Para tal objetivo, o estudo utilizará de duas ferramentas sendo uma delas uma escala objetiva e a outra subjetiva. A escala objetiva de uso será o peak flow nasal inspiratório, aparelho capaz de avaliar a permeabilidade das vias aéreas proximais, sendo assim capaz de mensurar o grau da obstrução nasal. Já a escala subjetiva de escolha é Nasal Obstruction Syndrome Evaluation (NOSEscale, sendo hoje uma referência para estudos que visam avaliar a obstrução nasal sobre a qualidade de vida e comparar o pré e pós de tratamentos clínicos e cirúrgicos.   Realizada a analise dos 30 pacientes, a cirurgia funcional nasal se mostrou muito benéfica revelando uma melhora na escala NOSE de 76% e no Peak Flow de 65%. O estudo tem como objetivo secundário comparar a evolução dos pacientes no primeiro e no sexto mês de pós operatório. Os pacientes apresentaram uma melhora de 18% no NOSE e de 8% no Peak Flow, revelando uma melhora no pós-operatório mais tardio. Em relação à melhora dos pacientes após o ato cirúrgico, notamos que nenhum dos pacientes passa a apresentar um peak flow

  20. Prevalência de Síndromes Funcionais em Estudantes e Residentes de Medicina

    Directory of Open Access Journals (Sweden)

    Gisele Araújo Pereira

    Full Text Available RESUMO O curso universitário é gerador de estresse, e, de acordo com a literatura, há elevada prevalência de sintomas depressivos e transtornos emocionais em até metade dos universitários. Cerca de um terço das pessoas com síndromes funcionais ou síndromes somáticas funcionais (SSF sofre de ansiedade ou depressão. Percebe-se, assim, a associação das SSF com fatores psicossociais e estresse. Objetivo Verificar a prevalência de síndrome funcional em estudantes e residentes de Medicina. Métodos Foram entrevistados 200 estudantes da Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG que cursavam o quinto, sexto, nono e décimo períodos, sendo 25 homens e 25 mulheres de cada período, bem como 27 residentes de várias especialidades do Hospital das Clínicas da UFMG (11 homens e 16 mulheres. Os voluntários responderam aos questionários Beck Depression Inventory (BDI e Stait-Trait Anxiety Inventory (Stai, ambos validados no Brasil para avaliação da depressão e ansiedade, e a questionário para verificar a presença de síndromes funcionais. Resultados Oitenta e sete indivíduos (38,3% tiveram o diagnóstico de síndrome somática e funcional (SSF, sendo prevalente nos residentes (48,1% e nos alunos do quinto ano (43% e menor nos alunos do terceiro ano (30%. Mulheres e seguidores da religião espírita foram os que apresentaram maior associação com SSF (p < 0,05, assim como os que possuíam maiores pontuações no questionário de avaliação de depressão e aqueles em período de formação mais avançado no curso médico. A SSF foi mais encontrada em estudantes com idade menor que 24 anos (39,4%, com renda inferior a dez salários mínimos (53,2%, casados (46,7%, com filhos (80%, entre os que possuíam parentesco médico (40,8, em tabagistas e alcoolistas (58,5% e em estudantes com traços de ansiedade alta (45,6%. Conclusão As síndromes funcionais são frequentes entre os estudantes e residentes de Medicina

  1. HDL cholesterol: atherosclerosis and beyond

    NARCIS (Netherlands)

    Bochem, A.E.

    2013-01-01

    Cardiovascular disease (CVD) is the leading cause of death in the Western world. Myocardial infarction and stroke are the result of a compromised blood flow which may result from cholesterol accumulation in the vessel wall due to high plasma levels of LDL cholesterol. High plasma levels of HDL

  2. Repetições CAG: candidatos na gênese das psicoses funcionais

    Directory of Open Access Journals (Sweden)

    Lima Ivanor Velloso Meira

    1999-01-01

    Full Text Available O autor discorre sobre a instabilidade do DNA em regiões de repetições CAG e sua associação com doenças que afetam o SNC e apresentam o fenômeno da antecipação genética. Revisa também os achados de antecipação em famílias com transtorno bipolar e esquizofrenia, assim como as investigações com o método RED (Repeat Expansion Detection e com o anticorpo 1C2, que apontam para uma participação desse mecanismo mutacional na determinação genética das psicoses funcionais.

  3. Instrumentos de avaliação para limitações funcionais associadas à instabilidade crônica de tornozelo: uma revisão sistemática da literatura Assessment instruments for chronic ankle instability: a systematic review of literature

    Directory of Open Access Journals (Sweden)

    Eneida Yuri Suda

    2012-03-01

    Full Text Available A instabilidade de tornozelo é definida como a sua tendência para sofrer falseios e entorses de repetição após a ocorrência de entorse lateral. Como a presença de instabilidade é definida por meio das queixas relatadas pelo indivíduo, apresenta caráter subjetivo, sendo importante identificar o melhor instrumento de avaliação para a determinação de sua presença e/ou gravidade. O objetivo deste estudo foi revisar, de forma sistemática, instrumentos de avaliação concebidos para pacientes com instabilidade crônica de tornozelo. Foram realizadas pesquisas bibliográficas nas bases de dados PubMed, Embase, BVS, LILACS e SciELO para identificar os instrumentos elegíveis. No total, seis estudos foram incluídos e apresentaram cinco instrumentos diferentes - Foot and Ankle Disability Index (FADI, Ankle Joint Functional Assessment Tool (AJFAT, Foot and Ankle Ability Measure (FAAM, Ankle Joint Functional Assessment Tool (AII e Cumberland Ankle Instability Tool (CAIT. Foram encontrados instrumentos com qualidade que detectam limitações funcionais em indivíduos com instabilidade crônica de tornozelo, não sendo instrumentos válidos para diagnóstico de instabilidade. O CAIT mostrou-se a ferramenta mais completa, mas não foi validada em uma população específica de indivíduos com condição de instabilidade do tornozelo. Observa-se a necessidade de mais estudos clinimétricamente válidos a fim de atestar a sua validade para se obter uma ferramenta eficaz e completa da instabilidade funcional do tornozelo.Ankle instability is defined as the tendency of the ankle to "give way" and suffer recurrent sprains after a lateral ankle sprain. Since the presence of instability is defined by means of subjects' complaints, it has a subjective characteristic it is important to identify the best assessment tool to determine its presence and/or severity. The purpose of this study was to systematically review assessment instruments designed for

  4. AndroMDT : um método de testes funcionais dirigido por modelos para sistemas de software.

    OpenAIRE

    Henrique Fernandes de Campos

    2010-01-01

    Esta pesquisa aborda o desenvolvimento do AndroMDT, um Método de Testes Funcionais Dirigido por Modelos para Sistemas de Software. Este método se apoia nas características do Desenvolvimento Dirigido por Testes (Test Driven Development - TDD) e da Arquitetura Dirigida por Modelos (Model Driven Architecture - MDA). Nele, descreve-se a aplicação do método AndroMDT em um componente de software, envolvendo um estudo de caso de um projeto real. Esta pesquisa propiciou a especificação, execução, do...

  5. Anatomical and functional characteristics of the pelvic floor in nulliparous women submitted to three-dimensional endovaginal ultrasonography: case control study and evaluation of interobserver agreement Características anatômicas e funcionais do assoalho pélvico em nulíparas avaliadas por ultrassonografia tridimensional endovaginal: estudo caso-controle e avaliação da confiabilidade interobservador

    Directory of Open Access Journals (Sweden)

    Sthela Maria Murad-Regadas

    2013-03-01

    with the 3-D endovaginal ultrasonography. The method was found to be reliable to measure pelvic floor structures at rest and during Valsalva, and might therefore be suitable for identifying dysfunctions in symptomatic patients.OBJETIVO: Avaliar as medidas anatômicas e funcionais do assoalho pélvico utilizando a ultrassonografia tridimensional transvaginal em nulíparas assintomáticas sem disfunções do compartimento posterior evidenciado pela ecodefecografia. Demonstrar o grau de concordância entre observadores do método utilizado para medir as estruturas anatômicas. MÉTODOS: Voluntárias nulíparas assintomáticas foram submetidas à ecodefecografia para identificar alterações dinâmicas no compartimento posterior, incluindo aquelas anatômicas (retocele, intussuscepção, entero/sigmoidocele e descenso perineal e funcionais (ausência de relaxamento ou contração paradoxal do puborretal e avaliadas com ultrassonografia tridimensional transvaginal para determinar índices biométricos do hiato dos elevadores do ânus, espessura do músculo pubovisceral, comprimento da uretra, ângulo anorretal, posição da junção anorretal e posição do colo vesical. Todas as medidas foram comparadas em repouso e durante Valsalva; e determinado descenso perineal e do colo da bexiga. A variabilidade interobservador foi avaliada utilizando o coeficiente de correlação intraclasse. RESULTADOS: Foram avaliadas 34 voluntárias com a ecodefecografia e a ultrassonografia tridimensional transvaginal. Dessas, 20 foram incluídas no estudo. As 14 excluídas apresentavam alterações dinâmicas no compartimento posterior. Durante a manobra de Valsalva, a área hiatal foi significativamente maior. A uretra foi significantemente mais curta e o ângulo anorretal foi maior. Medidas em repouso e durante a Valsalva diferiram significativamente em relação à posição da junção anorretal e do colo vesical. A média de valor do descenso perineal e do descenso da bexiga foram de 0

  6. HDL Particle Measurement: Comparison of 5 Methods.

    Science.gov (United States)

    Matera, Robert; Horvath, Katalin V; Nair, Hari; Schaefer, Ernst J; Asztalos, Bela F

    2018-03-01

    HDL cell cholesterol efflux capacity has been documented as superior to HDL cholesterol (HDL-C) in predicting cardiovascular disease risk. HDL functions relate to its composition. Compositional assays are easier to perform and standardize than functional tests and are more practical for routine testing. Our goal was to compare measurements of HDL particles by 5 different separation methods. HDL subfractions were measured in 98 samples using vertical auto profiling (VAP), ion mobility (IM), nuclear magnetic resonance (NMR), native 2-dimensional gel electrophoresis (2D-PAGE), and pre-β1-ELISA. VAP measured cholesterol in large HDL 2 and small HDL 3 ; IM measured particle number directly in large, intermediate, and small HDL particles; NMR measured lipid signals in large, medium, and small HDL; 2D-PAGE measured apolipoprotein (apo) A-I in large (α1), medium (α2), small (α3-4), and pre-β1 HDL particles; and ELISA measured apoA-I in pre-β1-HDL. The data were normalized and compared using Passing-Bablok, Lin concordance, and Bland-Altman plot analyses. With decreasing HDL-C concentration, NMR measured a gradually lower percentage of large HDL, compared with IM, VAP, and 2D-PAGE. In the lowest HDL-C tertile, NMR measured 8% of large HDL, compared with IM, 22%; VAP, 20%; and 2D-PAGE, 18%. There was strong discordance between 2D-PAGE and NMR in measuring medium HDL ( R 2 = 0.356; r c = 0.042) and small HDL ( R 2 = 0.376; r c = 0.040). The 2D-PAGE assay measured a significantly higher apoA-I concentration in pre-β1-HDL than the pre-β1-ELISA (9.8 vs 1.6 mg/dL; R 2 = 0.246; r c = 0.130). NMR agreed poorly with the other methods in measuring large HDL, particularly in low HDL-C individuals. Similarly, there was strong discordance in pre-β1-HDL measurements between the ELISA and 2D-PAGE assays. © 2017 American Association for Clinical Chemistry.

  7. Alterações tomográficas e funcionais pulmonares em pacientes com hipogamaglobulinemia primária em reposição de imunoglobulina humana

    OpenAIRE

    Mayra de Barros Dorna

    2012-01-01

    Introdução: A Agamaglobulinemia, a Imunodeficiência Comum Variável (IDCV) e a Síndrome Hiper IgM (SHIGM) são imunodeficiência primárias predominantemente humorais que se beneficiam da reposição de imunoglobulina humana, com redução da morbimortalidade. No entanto, apesar da reposição adequada de imunoglobulina, complicações pulmonares podem ocorrer, influenciando o prognóstico destes pacientes. Objetivo: O objetivo do estudo foi descrever as alterações morfológicas e funcionais pulmonares em ...

  8. ASPECTOS COMPOSICIONAIS, PROPRIEDADES FUNCIONAIS, NUTRICIONAIS E SENSORIAIS DO LEITE DE CABRA: UMA REVISÃO

    Directory of Open Access Journals (Sweden)

    Danielle Barros Cenachi

    2011-10-01

    Full Text Available O objetivo deste trabalho foi realizar uma revisão de literatura sobre aspectos composicionais e propriedades funcionais, nutricionais e sensoriais do leite de cabra aplicados à sua tecnologia de processamento. A escassez de publicações contendo informações específicas sobre o leite de cabra motivou a realização deste artigo. Para a realização da revisão bibliográfica foi feita uma busca de artigos científicos nas bases de dados da SpringLink, Nature, Scientific Electronic Library Online, principalmente, acessados através do portal de periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior por intermédio do Sistema Integrado de Gestão Acadêmica da UFJF. As principais palavras-chave utilizadas como descritor do assunto foram "leite de cabra" em português, em inglês "goat milk" e em espanhol "leche de cabra". O leite de cabra tem um importante papel como fonte de cálcio, de gordura de elevada digestibilidade, de proteína de alto valor biológico e hipoalergenicidade. Comparando o leite caprino com o leite bovino em relação aos aspectos composicionais, observou-se que os leites das duas espécies são distintos. Informações específicas sobre o leite de cabra facilitam o seu processamento e desenvolvimento de novos produtos a partir deste. As propriedades nutricionais e funcionais do leite de cabra justificam sua singularidade e demonstram que o leite caprino e seus produtos representam um nicho promissor para diversificar e inovar a indústria láctea. As propriedades sensoriais relativas ao sabor e odor do leite de cabra representam dificuldades para a sua aceitação, sendo necessárias pesquisas para melhorar estas características.

  9. A Closer Look at Cardioprotective Function of HDL: Revise the HDL – Cholesterol Hypothesis?

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    Anna Meiliana

    2014-04-01

    Full Text Available BACKGROUND: The strong inverse association of plasma levels of high-density lipoprotein (HDL cholesterol with coronary heart disease (CHD found in human epidemiological studies led to the development of the ‘HDL cholesterol hypothesis’, which posits that intervention to raise HDL cholesterol will result in reduced risk of CHD. A number of recent developments have brought the potential protective role of HDL into question. Several clinical trials of agents that substantially raise HDL-C have been demonstrated to not reduce CHD event rates. CONTENT: For decades, HDL and HDL-cholesterol (HDL-C levels were viewed as synonymous, and modulation of HDL-C levels by drug therapy held great promise for the prevention and treatment of cardiovascular disease. Nevertheless, recent failures of drugs that raise HDL-C to reduce cardiovascular risk and the now greater understanding of the complexity of HDL composition and biology have prompted researchers in the field to redefine HDL. As such, the focus of HDL has now started to shift away from a cholesterol-centric view toward HDL particle number, subclasses, and other alternative metrics of HDL. Many of the recently discovered functions of HDL are, in fact, not strictly conferred by its ability to promote cholesterol flux but by the other molecules it transports, including a diverse set of proteins, small RNAs, hormones, carotenoids, vitamins, and bioactive lipids. Based on HDL’s ability to interact with almost all cells and deliver fat-soluble cargo, HDL has the remarkable capacity to affect a wide variety of endocrine-like systems. SUMMARY: There is a significant need to redefine HDL and its benefit. HDL transports a diverse set of functional proteins, including many binding proteins. HDL transports and deliver vitamins, carotenoids, and other small molecules. Moreover, HDL transports hormones, steroids and bile acids, and can modulate multiple endocrine pathways. HDLs also transport and deliver micro

  10. Relação entre testes funcionais e plataforma de força nas medidas de equilíbrio em atletas

    Directory of Open Access Journals (Sweden)

    Lucas Maciel Rabello

    2014-06-01

    Full Text Available INTRODUÇÃO: Poucos estudos correlacionaram as medidas de equilíbrio entre os principais testes funcionais e a plataforma de força em atletas. OBJETIVO: Determinar a relação entre três testes funcionais de equilíbrio com as principais medidas da plataforma de força em atletas. MÉTODO: Quinze atletas do sexo feminino praticantes de futebol de salão (futsal e handebol, com idades entre 13 a 17 anos participaram do estudo. As atletas realizaram três testes funcionais: 1 Star excursion balance test, 2 Salto lateral e 3 Figura em oito; além de um teste em apoio unipodal sobre uma plataforma de força com os olhos abertos durante 30 segundos. Os parâmetros do centro de pressão dos pés (COP foram calculados por análise estabilográfica. Para todos os testes (funcionais e plataforma, três tentativas foram realizadas e a média foi retida para as análises. RESULTADOS: As correlações entre os testes funcionais e a plataforma de força foram de r = 0,01 a -0,69 (fraca a moderada, dependendo da variável do COP. As melhores correlações (r = -0,69 foram encontradas entre o Star Excursion Balance Test de alcance e a área do COP, indicando que quanto maior a distância alcançada, melhor o equilíbrio. Segundo, uma correlação de fraca a moderada foi encontrada entre o teste da figura em oito e a área do COP (p. ex: r = 0.43. O teste de salto lateral não apresentou boa correlação com os obtidos na plataforma de força. CONCLUSÃO: Este estudo demonstrou que para a avaliação do equilíbrio em atletas de futsal e handebol feminino o teste Star Excursion Balance Test pode ser usados na ausência da plataforma de força para identificação de possíveis déficits de equilíbrio.

  11. Qualidade de leites fermentados funcionais elaborados a partir de bactérias ácido-lácticas isoladas de queijo de coalho

    OpenAIRE

    Viegas,R.P.; Souza,M.R.; Figueiredo,T.C.; Resende,M.F.S.; Penna,C.F.A.M.; Cerqueira,M.M.O.P.

    2010-01-01

    Leites fermentados foram elaborados a partir de bactérias ácido-lácticas com propriedades funcionais, isoladas de queijo de coalho com e sem a adição de concentrado proteico de soro (CPS). Características físico-químicas, microbiológicas e sensoriais dos produtos elaborados foram analisadas durante 40 dias de estocagem sob refrigeração a 8-10ºC. Todos os leites fermentados elaborados, independentemente da adição de CPS e da cultura utilizada, apresentaram contagens adequadas de bactérias (>10...

  12. Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL Function.

    Science.gov (United States)

    Millar, Courtney L; Duclos, Quinn; Blesso, Christopher N

    2017-03-01

    Strong experimental evidence confirms that HDL directly alleviates atherosclerosis. HDL particles display diverse atheroprotective functions in reverse cholesterol transport (RCT), antioxidant, anti-inflammatory, and antiapoptotic processes. In certain inflammatory disease states, however, HDL particles may become dysfunctional and proatherogenic. Flavonoids show the potential to improve HDL function through their well-documented effects on cellular antioxidant status and inflammation. The aim of this review is to summarize the basic science and clinical research examining the effects of dietary flavonoids on RCT and HDL function. Based on preclinical studies that used cell culture and rodent models, it appears that many flavonoids (e.g., anthocyanidins, flavonols, and flavone subclasses) influence RCT and HDL function beyond simple HDL cholesterol concentration by regulating cellular cholesterol efflux from macrophages and hepatic paraoxonase 1 expression and activity. In clinical studies, dietary anthocyanin intake is associated with beneficial changes in serum biomarkers related to HDL function in a variety of human populations (e.g., in those who are hyperlipidemic, hypertensive, or diabetic), including increased HDL cholesterol concentration, as well as HDL antioxidant and cholesterol efflux capacities. However, clinical research on HDL functionality is lacking for some flavonoid subclasses (e.g., flavanols, flavones, flavanones, and isoflavones). Although there has been a tremendous effort to develop HDL-targeted drug therapies, more research is warranted on how the intake of foods or specific nutrients affects HDL function. © 2017 American Society for Nutrition.

  13. Redes sociais em alimentos funcionais no paraná: relato pesquisa 10.5007/1518-2924.2007v12n24p111

    Directory of Open Access Journals (Sweden)

    Maria Inês Tomaél

    2007-12-01

    Full Text Available Redes sociais são constituídas por indivíduos que mobilizam esforços em seu entorno, são configuradas pelas interações entre atores que têm interesses comuns. As interações subjacentes à estrutura social promovem o compartilhamento da informação e do conhecimento em territórios específicos. Essa pesquisa teve como objetivo estudar o compartilhamento da informação na Rede de Cooperação e Inovação em Alimentos Funcionais no Estado do Paraná (RECINAF, com base no seu mapeamento. Para sua consecução foi empregada a metodologia Análise de Redes Sociais (ARS, que visa à identificação da estrutura de comunicação de um sistema, analisando-a mediante suas relações. Os resultados indicam que o compartilhamento da informação na rede ocorre intra-institucionalmente, as ligações entre as instituições científicas no Paraná é frágil e não há articulação para o adensamento da especialidade de Alimentos Funcionais. É necessário que essa articulação seja incentivada, o que pode ser desenvolvido pela coordenação da rede.

  14. HDL function is impaired in acute myocardial infarction independent of plasma HDL cholesterol levels

    NARCIS (Netherlands)

    Annema, Wijtske; Willemsen, Hendrik M.; de Boer, Jan Freark; Dikkers, Arne; van der Giet, Markus; Nieuwland, Wybe; Muller Kobold, Anna; van Pelt, L. Joost; Slart, Riemer H. J. A.; van der Horst, Iwan C. C.; Dullaart, Robin P. F.; Tio, Rene A.; Tietge, Uwe J. F.

    2016-01-01

    BACKGROUND: High-density lipoproteins (HDLs) protect against the development of atherosclerotic cardiovascular disease. HDL function represents an emerging concept in cardiovascular research. OBJECTIVE: This study investigated the association between HDL functionality and acute myocardial infarction

  15. Alimentos funcionais-um mercado em expansão?

    OpenAIRE

    Bento, Ofélia P

    2009-01-01

    Podem ser considerados como alimentos funcionais todos os alimentos que, além das suas propriedades nutritivas, providenciem efeitos benéficos para a saúde de quem os consome. O interesse por este tipo de alimentos começou a emergir no Japão por volta dos anos 80, constituindo-se actualmente como um mercado em grande expansão. Embora seja um conceito bastante antigo nos países asiáticos, onde muitos alimentos foram associados a benefícios terapêuticos, só no início do século vinte é que se co...

  16. Niacin to Boost Your HDL "Good" Cholesterol

    Science.gov (United States)

    Niacin can boost 'good' cholesterol Niacin is a B vitamin that may raise your HDL ("good") cholesterol. But side effects might outweigh benefits for most ... been used to increase high-density lipoprotein (HDL) cholesterol — the "good" cholesterol that helps remove low-density ...

  17. Hepatic Proprotein Convertases Modulate HDL Metabolism

    Science.gov (United States)

    Jin, Weijun; Wang, Xun; Millar, John S.; Quertermous, Thomas; Rothblat, George H.; Glick, Jane M.; Rader, Daniel J.

    2007-01-01

    SUMMARY The risk of atherosclerosis is inversely associated with plasma levels of high-density lipoprotein cholesterol (HDL-C). However, HDL metabolism is incompletely understood, and there are few effective approaches to modulate HDL-C levels. Here we show that inhibition in the liver of the classical proprotein convertases (PCs), but not the atypical PCs S1P and PCSK9, decreases plasma HDL-C levels. This metabolic effect of hepatic PCs is critically dependent on expression of endothelial lipase (EL), an enzyme that directly hydrolyzes HDL phospholipids and promotes its catabolism. Hepatic PCs reduce EL function through direct inactivating cleavage of EL as well as through activating cleavage of angiopoietin-like protein 3 (ANGPTL3), an endogenous inhibitor of EL. Thus, inhibition of hepatic PCs results in increased EL activity, leading to reduced HDL-C as well as impaired reverse cholesterol transport. The hepatic PC-ANGPTL3-EL-HDL pathway is therefore a novel mechanism controlling HDL metabolism and cholesterol homeostasis. PMID:17681148

  18. High density lipoprotein (HDL) metabolism in noninsulin-dependent diabetes mellitus: measurement of HDL turnover using tritiated HDL

    Energy Technology Data Exchange (ETDEWEB)

    Golay, A.; Zech, L.; Shi, M.Z.; Chiou, Y.A.; Reaven, G.M.; Chen, Y.D.

    1987-09-01

    High density lipoprotein (HDL) kinetics were studied by injecting (/sup 3/H)apoprotein A-I (apoA-I)/HDL into 12 subjects with normal glucose tolerance and 12 patients with noninsulin-dependent diabetes mellitus (NIDDM). The results indicate that the mean fractional catabolic rate (FCR) of apoA-I/HDL was significantly faster (0.63 +/- 0.07 (+/- SEM) vs. 0.39 +/- 0.02 1/day; P less than 0.001) and the apoA-I/HDL synthetic rate greater (29.4 +/- 2.9 vs. 22.9 +/- 1.3 mg/kg X day; P less than 0.02) in patients with NIDDM than in normal subjects. Furthermore, there were statistically significant inverse relationships between apoA-I/HDL FCR and plasma levels of both HDL cholesterol (r = -0.71; P less than 0.001) and apoA-I (r = -0.63; P less than 0.001). In addition, the increase in apoA-I/HDL FCR was directly related to fasting plasma glucose (r = 0.78; P less than 0.001) and insulin (r = 0.76; P less than 0.001) concentrations. These data support the view that the decrease in plasma HDL cholesterol and apoA-I levels commonly found in patients with noninsulin-dependent diabetes is due to an increase in the catabolic rate of apoA-I/HDL secondary to the defects in carbohydrate metabolism present in these patients.

  19. High density lipoprotein (HDL) metabolism in noninsulin-dependent diabetes mellitus: measurement of HDL turnover using tritiated HDL

    International Nuclear Information System (INIS)

    Golay, A.; Zech, L.; Shi, M.Z.; Chiou, Y.A.; Reaven, G.M.; Chen, Y.D.

    1987-01-01

    High density lipoprotein (HDL) kinetics were studied by injecting [ 3 H]apoprotein A-I (apoA-I)/HDL into 12 subjects with normal glucose tolerance and 12 patients with noninsulin-dependent diabetes mellitus (NIDDM). The results indicate that the mean fractional catabolic rate (FCR) of apoA-I/HDL was significantly faster [0.63 +/- 0.07 (+/- SEM) vs. 0.39 +/- 0.02 1/day; P less than 0.001] and the apoA-I/HDL synthetic rate greater (29.4 +/- 2.9 vs. 22.9 +/- 1.3 mg/kg X day; P less than 0.02) in patients with NIDDM than in normal subjects. Furthermore, there were statistically significant inverse relationships between apoA-I/HDL FCR and plasma levels of both HDL cholesterol (r = -0.71; P less than 0.001) and apoA-I (r = -0.63; P less than 0.001). In addition, the increase in apoA-I/HDL FCR was directly related to fasting plasma glucose (r = 0.78; P less than 0.001) and insulin (r = 0.76; P less than 0.001) concentrations. These data support the view that the decrease in plasma HDL cholesterol and apoA-I levels commonly found in patients with noninsulin-dependent diabetes is due to an increase in the catabolic rate of apoA-I/HDL secondary to the defects in carbohydrate metabolism present in these patients

  20. QUITOSANA: UM AMINO POLISSACARÍDIO COM CARACTERÍSTICAS FUNCIONAIS

    Directory of Open Access Journals (Sweden)

    C. DAMIAN

    2009-01-01

    Full Text Available

    A obesidade pode ser vista como um excesso de adiposidade que leva riscos à saúde. Este risco, incorrido pela pessoa obesa, é provavelmente contínuo com o aumento da adiposidade. A saúde começa a ser afetada com um excesso de 20 % do peso. De acordo com a Organização Mundial da Saúde, a obesidade está aumentando para proporções epidêmicas em paises ocidentais e subdesenvolvidos ao redor do mundo. O crescimento epidêmico é predominantemente maior nas classes menos favorecidas. A obesidade leve (sobrepeso entre 10 e 25 % acarreta aumentos no risco para a morte prematura, diabetes, hipertensão, arteriosclerose e certos tipos de cânceres, estando associadas 44 diferentes doenças. Em função das conseqüências à saúde, a prevenção e o tratamento do sobrepeso e obesidade, seriam de grande interesse da população. Na maioria das sociedades industrializadas, recomenda-se que os consumidores reduzam sua ingestão de energia e gordura a 30 % ou menos do total de calorias. A produção de alimento com baixo valor calórico inclui produtos cárneos com reduzido teor de gordura. O teor de gordura dos produtos cárneos como salsichas e mortadelas, apresentam propriedades funcionais específicas, capaz de interferir nas características sensoriais relacionadas com o sabor e a textura.

  1. Aspectos estruturais e funcionais do apoio social de idosos do Município de São Paulo, Brasil

    OpenAIRE

    Rosa,Tereza Etsuko da Costa; Benício,Maria Helena D'Aquino; Alves,Maria Cecília Goi Porto; Lebrão,Maria Lúcia

    2007-01-01

    Este trabalho teve como objetivo descrever a distribuição das redes sociais e de apoio em idosos no Município de São Paulo, Brasil, por características sócio-econômicas e demográficas. Estudou-se amostra probabilística de 1.568 idosos (60 ou mais anos) da cidade de São Paulo (inquérito sobre Saúde, Bem-estar e Envelhecimento - SABE), focalizando-se as dimensões estruturais e funcionais das redes sociais. Para a análise dos dados utilizou-se a regressão logística simples e múltipla. As melhore...

  2. Anion exchange HPLC isolation of high-density lipoprotein (HDL and on-line estimation of proinflammatory HDL.

    Directory of Open Access Journals (Sweden)

    Xiang Ji

    Full Text Available Proinflammatory high-density lipoprotein (p-HDL is a biomarker of cardiovascular disease. Sickle cell disease (SCD is characterized by chronic states of oxidative stress that many consider to play a role in forming p-HDL. To measure p-HDL, apolipoprotein (apo B containing lipoproteins are precipitated. Supernatant HDL is incubated with an oxidant/LDL or an oxidant alone and rates of HDL oxidation monitored with dichlorofluorescein (DCFH. Although apoB precipitation is convenient for isolating HDL, the resulting supernatant matrix likely influences HDL oxidation. To determine effects of supernatants on p-HDL measurements we purified HDL from plasma from SCD subjects by anion exchange (AE chromatography, determined its rate of oxidation relative to supernatant HDL. SCD decreased total cholesterol but not triglycerides or HDL and increased cell-free (cf hemoglobin (Hb and xanthine oxidase (XO. HDL isolated by AE-HPLC had lower p-HDL levels than HDL in supernatants after apoB precipitation. XO+xanthine (X and cf Hb accelerated purified HDL oxidation. Although the plate and AE-HPLC assays both showed p-HDL directly correlated with cf-Hb in SCD plasma, the plate assay yielded p-HDL data that was influenced more by cf-Hb than AE-HPLC generated p-HDL data. The AE-HPLC p-HDL assay reduces the influence of the supernatants and shows that SCD increases p-HDL.

  3. Transferências lipídicas para HDL em diabéticos tipo 2: associações com microalbuminúria, estatina e insulina Transferencias lipídicas hacia HDL en diabéticos tipo 2: asociaciones con microalbuminuria, estatina y insulina Lipid transfer to HDL in type-2 diabetic patients: associations with microalbuminuria, statin, and insulin

    Directory of Open Access Journals (Sweden)

    Gilson Soares Feitosa-Filho

    2009-02-01

    Full Text Available FUNDAMENTO: O diabete melito tipo 2 (DM2 é um fator de risco isolado para coronariopatia, principalmente quando associado à microalbuminúria (MA. Alterações estruturais e funcionais das lipoproteínas não são totalmente esclarecidas nesse contexto. OBJETIVO: Avaliar a transferência de lípides para HDL (T em pacientes DM2 e a associação com a presença da MA e com o tratamento com estatina ou insulina. MÉTODOS: Estudamos 33 pacientes com DM2 e 34 controles pareados para idade. Uma nanoemulsão lipídica artificial radiomarcada com ³H-Triglicéride (TG e 14C-colesterol livre (CL ou ³H-colesterol éster (CE e 14C-fosfolípide (FL foi incubada com plasma. A nanoemulsão e as lipoproteínas foram precipitadas, exceto a HDL, que teve sua radioatividade contada. RESULTADOS: A TFL (% foi maior no grupo com DM2 que no grupo-controle (25,2±3,2 e 19,7±3,2 respectivamente; p FUNDAMENTO: La diabetes mellitus tipo 2 (DM2 es un factor de riesgo aislado para coronariopatía, principalmente cuando asociado a la microalbuminuria (MA. Alteraciones estructurales y funcionales de las lipoproteínas no están totalmente aclaradas en ese contexto. OBJETIVO: Evaluar no sólo la transferencia de lípidos hacia HDL (T en pacientes DM2, sino también la asociación tanto con la presencia de la MA como con el tratamiento con estatina o insulina. MÉTODOS: Estudiamos a 33 pacientes con DM2 y 34 controles pareados para edad. Se incubó con plasma una nanoemulsión lipídica artificial radiomarcada con ³H-Triglicérido (TG y 14C-colesterol libre (CL o ³H-colesterol esterificado (CE y 14C-fosfolípido (FL. Se procedió a la precipitación de la nanoemulsión y de las lipoproteínas, con excepción de la HDL, que tuvo su radioactividad contada. RESULTADOS: El valor de TFL (% resultó mayor en el grupo con DM2 en confrontación con el grupo-control (25,2±3,2 y 19,7±3,2 respectivamente; p BACKGROUND: Type-2 diabetes mellitus (T2DM is an isolated risk factor

  4. HDL (Good), LDL (Bad) Cholesterol and Triglycerides

    Science.gov (United States)

    ... be measured by a blood test. LDL (Bad) Cholesterol LDL cholesterol is called “bad” cholesterol. Think of it ... A high triglyceride level combined with low HDL cholesterol or high LDL cholesterol is linked with fatty buildups in artery ...

  5. Chá verde (Camellia sinensis e suas propriedades funcionais nas doenças crônicas não transmissíveis = Green tea (Camellia sinensis and its functionals properties on transmissible chronic diseases

    Directory of Open Access Journals (Sweden)

    Senger, Ana Elisa Vieira

    2010-01-01

    Conclusões: apesar de todas as evidências promissoras sobre as propriedades funcionais do chá verde nas doenças crônicas não transmissíveis, investigações adicionais são necessárias para a compreensão da sua real contribuição para a saúde humana

  6. Computer arithmetic and verilog HDL fundamentals

    CERN Document Server

    Cavanagh, Joseph

    2009-01-01

    Verilog Hardware Description Language (HDL) is the state-of-the-art method for designing digital and computer systems. Ideally suited to describe both combinational and clocked sequential arithmetic circuits, Verilog facilitates a clear relationship between the language syntax and the physical hardware. It provides a very easy-to-learn and practical means to model a digital system at many levels of abstraction. Computer Arithmetic and Verilog HDL Fundamentals details the steps needed to master computer arithmetic for fixed-point, decimal, and floating-point number representations for all prima

  7. The effect of acid hydrolysis on the technological functional properties of pinhão (Araucaria brasiliensis starch Efeito da hidrólise ácida nas propriedades funcionais tecnológicas do amido de pinhão (Araucaria brasiliensis

    Directory of Open Access Journals (Sweden)

    Roberta Cruz Silveira Thys

    2013-02-01

    Full Text Available Technological functional properties of native and acid-thinned pinhão (seeds of Araucária angustifolia, Brazilian pine starches were evaluated and compared to those of native and acid-thinned corn starches. The starches were hydrolyzed (3.2 mol.L-1 HCl, 44 ºC, 6 hours and evaluated before and after the hydrolysis reaction in terms of formation, melting point and thermo-reversibility of gel starches, retrogradation (in a 30-day period and measurements every three days, paste freezing and thawing stability (after six freezing and thawing cycles, swelling power, and solubility. The results of light transmittance (% of pastes of native and acid-thinned pinhão starches was higher (lower tendency to retrogradation than that obtained for corn starches after similar storage period. Native pinhão starch (NPS presented lower syneresis than native corn starch (NCS when submitted to freeze-thaw cycles. The acid hydrolysis increased the syneresis of the two native varieties under storage at 5 ºC and after freezing and thawing cycles. The solubility of NPS was lower than that of native corn starch at 25, 50, and 70 ºC. However, for the acid-thinned pinhão starch (APS, this property was significantly higher (p As propriedades funcionais tecnológicas do amido nativo e modificado (hidrólise ácida de pinhão (Araucaria angustifólia foram comparadas às propriedades do amido nativo e ácido hidrolisado de milho. As espécies de amido foram hidrolisadas (3.2 mol.L-1 HCl, 44 ºC, 6 horas e avaliadas, antes e após a reação de hidrólise, de acordo com as análises de formação, fusão e termorreversão do gel, retrogradação (em um período de 30 dias, com medidas a cada 3 dias, estabilidade ao congelamento e descongelamento (após 6 ciclos de congelamento e descongelamento, poder de inchamento e índice de solubilidade. Os resultados obtidos demonstraram que o amido de pinhão apresenta menor tendência à retrogradação quando comparado ao amido

  8. Análise de parâmetros funcionais relacionados aos fatores de risco ocupacionais da atividade de enfermeiros de UTI Análisis de parámetros funcionales relacionados a los factores de riesgos laborales de la actividad de enfermeros de UTI Analysis of functional parameters related to occupational risk factors of ICU nursing activity

    Directory of Open Access Journals (Sweden)

    Denise Nery

    2013-03-01

    Full Text Available A avaliação de fatores como fadiga e aspectos funcionais pode identificar sobrecargas durante a atividade de enfermeiros. O objetivo foi avaliar a necessidade de descanso, prevalência de desconfortos musculoesqueléticos, capacidade de trabalho e esforço físico de enfermeiros de Unidade de Terapia Intensiva (UTI. Participaram 24 enfermeiros (idade 40±8 anos; 14 homens e 10 mulheres. Foram aplicados: questionário nórdico de sintomas, índice de capacidade para trabalho (ICT, escala de necessidade de descanso (ENEDE e escala de esforço percebido (Borg. Diferenças entre sexos foram verificadas pelo teste t de Student e na prevalência pelo teste exato de Fisher. Verificou-se prevalência de 75% nos últimos 12 meses, sendo 100% das mulheres e 42% dos homens (diferença significante; p=0,024. As mulheres classificaram o trabalho como mais intenso em comparação aos homens (pLa evaluación de factores como fatiga y aspectos funcionales pueden identificar sobrecargas durante la actividad de los enfermeros. El objetivo fue evaluar la necesidad de descanso, prevalencia de molestias musculoesqueléticas, capacidad de trabajo y esfuerzo físico de enfermeros de UTI. Participaron 24 enfermeros (edad 40±8 años; 14 hombres/10 mujeres. Fueron aplicados: cuestionario nórdico de síntomas, índice de capacidad para el trabajo (ICT, escala de necesidad de descanso (ENEDE y escala de esfuerzo percibido (Borg. Diferencias entre sexos fueron verificadas por el test t de Student y la prevalencia por el test exacto de Fisher. Se verificó la prevalencia del 75% en los últimos 12 meses, siendo el 100% de las mujeres y 42% de los hombres (diferencia significativa; p=0,024. Las mujeres clasificaron el trabajo como más intenso en comparación a los hombres (pEvaluating factors such as fatigue and functional aspects can identify overloads during nursing activities. The aim was to evaluate need for recovery, prevalence of musculoskeletal discomfort, working

  9. Functional Foods: a new frontier for developing whey based protein beveragesAlimentos funcionais: uma nova fronteira para o desenvolvimento de bebidas protéicas a base de soro de leite

    Directory of Open Access Journals (Sweden)

    Ana Lúcia Barretto Penna

    2011-10-01

    Full Text Available Functional foods are defined as those that provide additional benefits to consumers. The market for foods with functional properties is expanding, supported by scientific evidences, which leads the developing of different special foods. This market segment is related to the innovations, as well as the traditional functional dairy and non dairy products, gain traction in the marketplace for innovative products like based whey sports beverage. Besides the functionality of muscle protein synthesis, these beverages are entering into areas such as clinical nutrition and satiety. Thus, it can be supposed that the composition and technological versatility of the whey support the use as innovative ingredient for foods and beverages. This review aim to supply an overview about functional foods, mainly the segment of whey based beverages. The success of this new nutritional approach is close related to the requirement to identify, to characterize and to develop methodologies to measure and to validate more precisely the relevant functional markers, making them open for a public domain.Alimentos funcionais são definidos como aqueles que fornecem benefícios adicionais aos da alimentação. O mercado de alimentos com propriedades funcionais está em crescente expansão, apoiado por evidências científicas, que creditam o desenvolvimento de alimentos diferenciados. Esse segmento está relacionado às inovações, pois além dos tradicionais produtos funcionais lácteos e não lácteos, ganham espaço no mercado produtos inovadores como bebidas especiais para esportistas a base de soro de leite. Além da funcionalidade sobre a síntese protéica muscular, estas bebidas protéicas estão se inserindo em áreas como a da saciedade e da nutrição clínica. Assim, é possível afirmar que o soro de leite se diferencia como ingrediente de inovação em alimentos e bebidas, porque demonstra uma grande versatilidade tecnológica. Esta revisão objetiva fornecer

  10. Integração de linguagens funcionais à plataforma .NET utilizando o framework Phoenix

    OpenAIRE

    AVELINO, Guilherme Amaral

    2008-01-01

    Linguagens funcionais se destacam pelo seu alto poder de expressão e abstração, promovido por construções de alto nível como polimorfismo paramétrico, funções de alto nível e aplicações parciais. Embora estes recursos sejam bastante úteis, tradicionalmente, linguagens funcionais têm sido pouco empregadas fora do ambiente acadêmico. Esta situação é em parte explicada pela ausência de uma infra-estrutura de desenvolvimento que forneça ferramentas e APIs capazes de aumentar a p...

  11. Quais os parâmetros funcionais que permitem diferenciar asma grave de DPOC?

    Directory of Open Access Journals (Sweden)

    Ricardo Marques Dias

    2010-03-01

    Full Text Available Resumo: Com o objectivo de identificar parâmetros funcionais respiratórios que contribuam para o diagnóstico diferencial entre asma e DPOC, estudámos 20 asmáticos e 30 bronquíticos, com ou sem enfisema, com os exames usuais de função pulmonar: espirografia, pletismografia e DLCO, pré e pós-broncodilatação para os dois primeiros exames. Os grupos apresentam diferenças significativas na sua constituição. Os asmáticos são mais jovens, média de 48 anos, contra 59 anos no grupo com DPOC, e o grupo é constituído predominantemente por mulheres, 65% contra 40%, respectivamente. Os exames funcionais pulmonares, realizados conforme as directrizes internacionais, mostram, pela espirografia, que os asmáticos têm obstrução mais intensa, VEF1/CVF de 59 versus 66 e maior resposta broncodilatadora pelo VEF1, quer em valor absoluto, quer por variação percentual, do basal (% ou do valor previsto (%P. A DLCO mostra-se, em média, normal entre os asmáticos, 103%P, e diminuída no grupo com DPOC, 69%P. Na pletismografia constatámos que os asmáticos têm maior volume residual (%P e resistência de vias aéreas. Concluímos que vários parâmetros funcionais diferenciam a asma da DPOC, como um grupo; na análise individual, a DLCO é o parâmetro que melhor discrimina as duas doenças, possuindo maior especificidade para o diagnóstico de DPOC, seguida pelas variações de VEF1 na broncodilatação, com maior sensibilidade para o diagnóstico de asma. Desta forma, estes dois exames são destaque no diagnóstico diferencial das doenças obstrutivas.Rev Port Pneumol 2010; XVI (2: 253-272 Abstract: The aim of this study was to identify the respiratory function parameters that help in the accurate diagnosis of asthma and COPD. We studied 20 asthma and 30 COPD patients who underwent lung function tests including spirometry and plethysmography

  12. PROSPECÇÃO TECNOLÓGICA E CIENTÍFICA DE ALIMENTOS PROBIÓTICOS FUNCIONAIS NA FORMA DE BARRA DE CEREAIS

    Directory of Open Access Journals (Sweden)

    Bárbara Verônica Sousa Cardoso

    2015-09-01

    Full Text Available Nos países desenvolvidos é crescente a popularidade dos alimentos funcionais contendo probióticos e isto se deve aos avanços nas pesquisas em desenvolvimento de novos produtos, que resultaram na incorporação de probióticos não só em produtos lácteos, mas também em bebidas, e até mesmo em cereais e chocolates. O objetivo desse trabalho foi realizar uma prospecção tecnológica e científica de alimentos probióticos funcionais na forma de barra de cereais. Foram pesquisados depósitos de patentes nas bases EPO, WIPO, USPTO e INPI e artigos publicados no banco de dados da Web of Science, Scielo, Science Direct, Portal Periódicos Capes e Medline. Com a combinação dos termos cereal bars e probiotics, a busca resultou em 9 e 3 patentes,nas bases USPTO e WIPO, respectivamente. Após a análise, constatou-se que os Estados Unidos e a Alemanha foram os maiores depositantes nas bases internacionais. Entretanto, no INPI não foi encontrado nenhum depósito. Quanto aos artigos, obteve-se, apenas 14, na base de dados Scielo, com os termos food bar e lactobacillus. De acordo com os resultados desta prospecção, pesquisas sobre alimentos probióticos funcionais são necessárias, no Brasil, devido ao pequeno número de depósitos de patentes nas diferentes bases pesquisadas e artigos publicados.

  13. HDL in sepsis - risk factor and therapeutic approach

    Directory of Open Access Journals (Sweden)

    Emily E Morin

    2015-10-01

    Full Text Available High-density lipoprotein (HDL is a key component of circulating blood and plays essential roles in regulation of vascular endothelial function and immunity. Clinical data demonstrate that HDL levels drop by 40-70% in septic patients, which is associated with a poor prognosis. Experimental studies using Apolipoprotein A-I (ApoAI null mice as an HDL deficient model showed that mice lacking HDL are susceptible to septic death, and overexpressing ApoAI in mice to increase HDL levels protects against septic death. These clinical and animal studies support our hypothesis that a decrease in HDL level is a risk factor for sepsis, and raising circulating HDL levels may provide an efficient therapy for sepsis. In this review, we discuss the roles of HDL in sepsis and summarize the efforts of using synthetic HDL as a potential therapy for sepsis.

  14. Alterações funcionais da junção neuromuscular provocadas em ratos pela administração diária e prolongada de um agente curarizante Functional changes of the neuromuscular junction induced in rats by a daily and prolonged ministration of a curare agent

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Zanini

    1967-06-01

    Full Text Available A ratos adultos, machos, foi administrado durante 8 semanas, uma vez ao dia, o iodeto do dimetiléter da d-tubocurarina (DMT, pela via intraperitoneal. Os animais foram distribuídos em 3 lotes: os do 1.°, receberam 5,5 gama de DMT/kg/dia; os do 2.°, 16,6 gama/kg/dia; os do 3.° (controle, 1 ml da solução isotônica de cloreto de sódio. A força muscular dos animais foi avaliada uma vez por semana, de acordo com o método descrito no texto, antes e após a injeção intraperitoneal da referida substância. Com o decorrer da experimentação, observou-se que: a houve diminuição significativa da força muscular dos animais, avaliada após esvaecimento da atividade curarizante do DMT; b a determinação da força muscular, feita logo após a injeção, mostrou que a dose de 5,5 gama/kg/dia provoca um aumento da suscetibilidade dos animais à ação curarizante do DMT; c o efeito inibidor provocado pela dose de 16,6 gama/kg/dia de DMT aumentou no início mas diminuiu significantemente após a 5ª semana, muito embora houvesse uma progressiva diminuição da força muscular, sugerindo independência entre os dois efeitos. Com base nesses resultados, são discutidos alguns fenômenos que podem ocorrer na instalação e tratamento da miastenia grave.Dimethylether of d-tubocurarine iodide (DMT was administered daily, by intraperitoneal route, to adult male rats during 8 weeks. The animals were divided in three groups: the animals of the first group were given 5.5 gama/kg/day of DMT; those of the second group were given 16.6 gama/ kg/day; the rats of the 3rd (the control group, received 1 cm³ of isotonic saline solution. The animals muscular force was evaluated once a week right before and after intraperitoneal injection of the drug. During the course of the trial, it was noted: aa significant reduction of the animals muscular force, evaluated after disappearance of the DMT curarizing effect; bmeasurements of muscular force, performed straight

  15. Large-Scale Candidate Gene Analysis of HDL Particle Features

    Science.gov (United States)

    Kaess, Bernhard M.; Tomaszewski, Maciej; Braund, Peter S.; Stark, Klaus; Rafelt, Suzanne; Fischer, Marcus; Hardwick, Robert; Nelson, Christopher P.; Debiec, Radoslaw; Huber, Fritz; Kremer, Werner; Kalbitzer, Hans Robert; Rose, Lynda M.; Chasman, Daniel I.; Hopewell, Jemma; Clarke, Robert; Burton, Paul R.; Tobin, Martin D.

    2011-01-01

    Background HDL cholesterol (HDL-C) is an established marker of cardiovascular risk with significant genetic determination. However, HDL particles are not homogenous, and refined HDL phenotyping may improve insight into regulation of HDL metabolism. We therefore assessed HDL particles by NMR spectroscopy and conducted a large-scale candidate gene association analysis. Methodology/Principal Findings We measured plasma HDL-C and determined mean HDL particle size and particle number by NMR spectroscopy in 2024 individuals from 512 British Caucasian families. Genotypes were 49,094 SNPs in >2,100 cardiometabolic candidate genes/loci as represented on the HumanCVD BeadChip version 2. False discovery rates (FDR) were calculated to account for multiple testing. Analyses on classical HDL-C revealed significant associations (FDRparticle size yielded additional associations in LIPC (hepatic lipase; rs261332: p = 6.1*10−9), PLTP (phospholipid transfer protein, rs4810479: p = 1.7*10−8) and FBLN5 (fibulin-5; rs2246416: p = 6.2*10−6). The associations of SGCD and Fibulin-5 with HDL particle size could not be replicated in PROCARDIS (n = 3,078) and/or the Women's Genome Health Study (n = 23,170). Conclusions We show that refined HDL phenotyping by NMR spectroscopy can detect known genes of HDL metabolism better than analyses on HDL-C. PMID:21283740

  16. Verilog HDL digital design and modeling

    CERN Document Server

    Cavanagh, Joseph

    2007-01-01

    PREFACE INTRODUCTION History of HDL Verilog HDL IEEE Standard Features Assertion Levels OVERVIEW Design Methodologies Modulo-16 Synchronous Counter Four-Bit Ripple Adder Modules and Ports Designing a Test Bench for Simulation Construct Definitions Introduction to Dataflow Modeling Two-Input Exclusive-OR Gate Four 2-Input AND Gates With Delay Introduction to Behavioral Modeling Three-Input OR Gate Four-Bit Adder Modulo-16 Synchronous Counter Introduction to Structural Modeling Sum-of-Products Implementation Full Adder Four-Bit Ripple Adder Introduction to Mixed-Design Modeling Full Adder Problems LANGUAGE ELEMENTS Comments Identifiers Keywords Bidirectional Gates Charge Storage Strengths CMOS Gates Combinational Logic Gates Continuous Assignment Data Types Module Declaration MOS Switches Multiple-Way Branching Named Ev...

  17. Biomarcadores do metabolismo da cartilagem e sua relação com as alterações morfológicas, inflamatórias e funcionais: um estudo sobre a lesão condral secundária em joelhos humanos

    OpenAIRE

    Renata Nogueron Franco

    2011-01-01

    A osteoartrite (OA), doença articular degenerativa, é uma das causas mais freqüentes de dor do sistema músculo-esquelético e de incapacidade para o trabalho no Brasil e no mundo. É uma doença crônica, multifatorial, que leva a uma incapacidade funcional progressiva. Pode surgir em decorrência de lesões em estruturas como ligamento cruzado anterior e/ou meniscos (OA pós-traumática), e neste caso, pode afetar indivíduos em qualquer faixa etária. O desenvolvimento da osteoartrite inclui múltipla...

  18. [Therapeutic targets in the treatment of dyslipidemia: HDL and non-HDL cholesterol].

    Science.gov (United States)

    Brea Hernando, Ángel Julián

    2014-07-01

    Atherogenic dyslipidemia (AD) consists of the combination of an increase in very low density lipoproteins (VLDL), which results in increased plasma triglyceride (TG) levels, with a reduction of levels of high-density lipoprotein bound cholesterol (HDL-C), also accompanied by a high proportion of small and dense LDL particles. AD is considered the main cause of the residual risk of experiencing cardiovascular disease (CVD), which is still presented by any patient on treatment with statins despite maintaining low-density lipoprotein bound cholesterol (LDL-C) levels below the values considered to be the objective. Non-HDL cholesterol (non-HDL-c) reflects the number of atherogenic particles present in the plasma. This includes VLDL, intermediate density lipoproteins (IDL) and LDL. Non-HDL-c provides a better estimate of cardiovascular risk than LDL-c, especially in the presence of hypertriglyceridemia or AD. The European guidelines for managing dyslipidemia recommend that non-HDL-c values be less than 100 and 130 mg/dL for individuals with very high and high cardiovascular risk, respectively. However, these guidelines state that there is insufficient evidence to suggest that raising HDL-c levels incontrovertibly results in a reduction in CVD. Therefore, the guidelines do not set recommended HDL-c levels as a therapeutic objective. The guidelines, however, state that individuals with AD on treatment with statins could benefit from an additional reduction in their risk by using fibrates. Copyright © 2014 Sociedad Española de Arteriosclerosis y Elsevier España, S.L. All rights reserved.

  19. High pre-beta1 HDL concentrations and low lecithin: cholesterol acyltransferase activities are strong positive risk markers for ischemic heart disease and independent of HDL-cholesterol

    DEFF Research Database (Denmark)

    Sethi, Amar A; Sampson, Maureen; Warnick, Russell

    2010-01-01

    We hypothesized that patients with high HDL-cholesterol (HDL-C) and ischemic heart disease (IHD) may have dysfunctional HDL or unrecognized nonconventional risk factors.......We hypothesized that patients with high HDL-cholesterol (HDL-C) and ischemic heart disease (IHD) may have dysfunctional HDL or unrecognized nonconventional risk factors....

  20. Functional extruded snacks with lycopene and soy protein Snacks extrusados funcionais com licopeno e proteína de soja

    Directory of Open Access Journals (Sweden)

    Paula Fernanda Pinto da Costa

    2010-03-01

    Full Text Available In this work, the effects of thermoplastic extrusion process parameters (raw material moisture content and temperature and the addition of functional ingredients (lycopene and soy protein on quality characteristics of a base-formulation for extruded corn snacks were studied, with the objective of developing an easy-to-eat functional product. A single-screw Labor PQ 30 model Inbramaq extruder was used for extrusion and a central composite rotational design (CCRD was followed. The independent variables were: i percentage of soy protein isolate (0-30%; ii percentage of lycopene preparation (0-0.1%; iii raw material moisture content (20-30%; and iv 5th zone temperature (100-150 °C. The expansion index reached maximum values with the lowest raw material moisture content (20% and intermediate temperatures (approximately 125 °C. Instrumental hardness was higher with high moisture and low temperature; however, increasing the percentage of soy protein was beneficial for the texture of the product, reducing hardness. The red color intensity increased with the increase in lycopene content and moisture, and with the reduction of temperature. Sensory acceptance tests were carried out for two products, with maximum percentages of the functional ingredients, 20% moisture and temperatures of 125 and 137 °C, with greater acceptance for the product extruded at 125 °C.Neste trabalho, estudou-se a influência de parâmetros do processo de extrusão termoplástica (umidade da matéria-prima e temperatura e da adição de ingredientes funcionais (licopeno e proteína de soja sobre características de qualidade de uma formulação-base para snacks extrusados de milho, com o objetivo de desenvolver um alimento funcional de fácil consumo. Utilizou-se um extrusor monorrosca Inbramaq, modelo Labor PQ 30, e seguiu-se um planejamento experimental com as seguintes variáveis independentes: i teor de isolado proteico de soja (0 a 30%; ii teor de preparado de licopeno (0

  1. Aspectos funcionais das catequinas do chá verde no metabolismo celular e sua relação com a redução da gordura corporal Functional aspects of green tea catechins in the cellular metabolism and their relationship with body fat reduction

    Directory of Open Access Journals (Sweden)

    Renata da Costa Lamarão

    2009-04-01

    Full Text Available O chá é uma bebida amplamente utilizada, perdendo apenas para a água como a bebida mais consumida no mundo. O chá verde é rico em polifenóis, principalmente catequinas. Entre uma variedade de efeitos benéficos à saúde atribuídos ao consumo do chá verde, grande atenção tem sido focalizada no seu efeito na redução da gordura corporal. Este estudo tem como objetivo apresentar uma descrição dos estudos com o chá verde e/ou seus compostos bioativos relacionados à biologia celular, estudos experimentais e epidemiológicos associados ao metabolismo lipídico e à redução da gordura corporal. Galato de epigalocatequina é o principal composto bioativo presente no chá verde e seus efeitos anti-obesidade estão sendo investigados. Tais efeitos estão associados a diversos mecanismos bioquímicos e fisiológicos, dentre eles podem-se destacar a estimulação do metabolismo lipídico pela combinação da ingestão de catequinas e a prática de exercícios físicos regulares. Apesar do efeito promissor do chá verde e seus compostos bioativos no tratamento da obesidade, estudos clínicos controlados devem ser conduzidos. Finalmente, um plano alimentar adequado associado à prática regular de atividade física constitui a principal ferramenta para a prevenção da obesidade e de suas comorbidades.The use of tea is widespread, second only to water in worldwide consumption. Green tea is rich in polyphenols, mainly catechins. Among a variety of beneficial health effects attributed to the consumption of the green tea, much attention has been given to its ability to reduce body fat. This study has the objective of presenting a description of the studies of green tea and/or its bioactive compounds related to cell biology and of experimental and epidemiological studies associated with lipid metabolism and the reduction of body fat. Epigallocatechin gallate is the main bioactive compound present in green tea and its anti-obesity effects are

  2. Genetics of HDL-C: a causal link to atherosclerosis?

    NARCIS (Netherlands)

    van Capelleveen, Julian C.; Bochem, Andrea E.; Motazacker, M. Mahdi; Hovingh, G. Kees; Kastelein, John J. P.

    2013-01-01

    Prospective epidemiological studies have consistently reported an inverse association between HDL cholesterol (HDL-C) levels and the risk of cardiovascular disease (CVD). However, large intervention trials on HDL-C-increasing drugs and recent Mendelian randomization studies have questioned a causal

  3. A construção discursiva de Dilma Rousseff: análise da primeira página de três jornais mineiros à luz dos estudos sistêmico-funcionais The discursive construction of Dilma Rousseff: a systemic functional analysis of three newspapers?

    Directory of Open Access Journals (Sweden)

    Maria Carmen Aires Gomes

    2012-01-01

    Full Text Available Esta pesquisa analisou a representação da presidente Dilma Rousseff, após o resultado das eleições de 2010 na capa de três jornais mineiros - Estado de Minas, Hoje em dia e Super Notícia -, de acordo com a abordagem Linguística Sistêmico-Funcional apresentada em Halliday (1994 e Halliday e Matthiessen (2004. Objetivo deste artigo é analisar a representação da presidente Dilma Rousseff após o resultado das eleições de 2010, na primeira página de três jornais mineiros, Estado de Minas, Hoje em Dia e Super Notícia, objetivando compreender quais as operações de seleções e escolhas lexicogramaticais foram suscitadas pelas mídias. Cada jornal se revelou ideológico pois deixou transparecer sua linha editorial por meio das escolhas.This research analyzes the representation of Dilma Rousseff, in the front page of three Minas Newspapers, after the results of the 2010 elections - Estado de Minas, Hoje em Dia and Super Notícia -, based on Systemic-Functional Linguistics (Halliday (1994 and Halliday e Matthiessen (2004. Our objective is to understand the ideology underlying the picture construed of the social actor candidate for the presidency. The picture of Dilma Rousseff painted revealed the ideology of the owner - editor - of each newspaper revealed representing the social actor Dilma Rousseff president on your way.

  4. Hortaliças como alimentos funcionais Vegetable crops as functional food

    Directory of Open Access Journals (Sweden)

    Patrícia G B de Carvalho

    2006-12-01

    Full Text Available Embora remonte às origens da civilização, a relação entre alimentação e saúde nunca foi tão estreita quanto nos dias de hoje. Dietas ricas em gordura, sal e açúcar e pobres em carboidratos complexos, vitaminas e minerais, aliadas a um estilo de vida mais sedentário, são responsáveis pelo aumento de doenças ligadas à dieta, tais como obesidade, diabetes, problemas cardiovasculares, hipertensão, osteoporose e câncer. Há muito tempo acredita-se que o consumo de frutas e hortaliças auxilia na prevenção destas doenças. As hortaliças são um importante componente da dieta, sendo tradicionalmente servidas junto com um alimento protéico e um carboidrato. Elas fornecem não apenas variedade de cor e textura às refeições, mas também nutrientes importantes. As hortaliças têm pouca gordura e calorias, relativamente pouca proteína, mas são ricas em carboidratos e fibras e fornecem níveis significativos de micronutrientes à dieta. Além disso, elas possuem compostos funcionais, que beneficiam uma ou mais funções orgânicas, além da nutrição básica, contribuindo para melhorar o estado de saúde e bem-estar e/ou reduzir o risco de doenças. O desenvolvimento de cultivares mais ricas nestes compostos tem se consolidado como um dos principais focos dos modernos programas de melhoramento genético de hortaliças. Vários destes programas, trabalhando com diferentes hortaliças, estão em andamento no Brasil e no mundo visando aumentar os teores e diversificar os tipos de carotenóides presentes na dieta. Neste trabalho são discutidos os principais aspectos relacionados às hortaliças como alimentos funcionais, bem como são detalhados os principais avanços obtidos nesta área no melhoramento de cenoura e tomate no Brasil.Although a very old concept, the relationship between food and health has never been as close as it is today. Diets rich in fat, salt, and sugar and poor in complex carbohydrates, vitamins, and minerals

  5. Intervenções em linguagem escrita: uma revisão da literatura com vistas à redução dos transtornos funcionais de aprendizagem Intervention in written language: a review of the literature focusing on reducing functional learning disorders

    Directory of Open Access Journals (Sweden)

    Jáima Pinheiro de Oliveira

    2011-12-01

    Full Text Available a importância de saber ler e escrever e utilizar essas habilidades nas mais diversas situações do dia a dia é uma realidade inquestionável. E, numa sociedade na qual a leitura e a escrita são largamente utilizadas, para os mais variados fins, o Brasil ainda enfrenta grandes problemas com a alfabetização, denunciados pelos altos índices de analfabetismo e pela grande demanda de escolares com dificuldades de aprendizagem. Considerando isso, nosso texto pretende apresentar um panorama de pesquisas com foco para os programas de intervenção, voltados para essa população, com especial atenção para aqueles que utilizam o gênero narrativo ou de histórias. A busca foi feita com base em critérios específicos, sendo o principal deles o período das publicações (2000 a 2010. Os resultados da análise de 15 textos indicaram que as principais lacunas na literatura nacional estão voltadas, exatamente, para a área de intervenção. Por outro lado, na literatura internacional há uma preocupação em relação a um rigor ou controle maior de variáveis, em relação aos programas desenvolvidos, assim como, da necessidade de medidas de generalização para uso efetivo desses programas, dentro das comunidades verbais, com destaque para as escolas. Além disso, há preocupações direcionadas para os componentes de instrução mais eficazes, o uso de diferentes gêneros textuais e estudos com grupos de escolares. Nossa revisão permitiu concluir que embora haja uma vasta produção na área de linguagem escrita, no que tange os programas de intervenção, a literatura internacional é mais expressiva. Além disso, tanto na literatura nacional, quanto na internacional, a produção acerca da compreensão do processo de aquisição e desenvolvimento dessa habilidade ainda é predominante.The importance reading and writing and being able to use these skills in a variety of situations is an absolute reality. In our society in which reading and

  6. Water of coconut: Nutritional and functional properties and processing/ Água-de-coco: Propriedades nutricionais, funcionais e processamento

    Directory of Open Access Journals (Sweden)

    Geraldo Arraes Maia Junior

    2006-06-01

    Full Text Available This review presents the important aspects of the coconut water, such as its chemical composition, nutritional value and functional properties, which allied to its sweetened taste, turned it into a much appreciated beverage, favoring the increase of its consumption. It also reports the types of commercialization of the coconut water and the related aspects of the industrialization of the coconut water, balancing the offer of green coconut along the year. The important factors during the industrialization of the coconut water were emphasized and the researches that have been accomplished for the extension of its shelf life, obtaining products that maintain as much as possible its original sensorial characteristics.Esta revisão apresenta os aspectos relevantes da àgua-de-coco, como os relacionados com sua composição química, valor nutritivo e propriedades funcionais, que aliadas a seu sabor adocicado, tornaram-na uma bebida muito apreciada, favorecendo o aumento do seu consumo. Também aborda as formas de comercialização da água-de-coco destacando-se os aspectos relacionados à industrialização que equilibram a oferta do produto ao longo do ano. Os fatores importantes durante o processamento da água-de-coco foram enfatizados e as pesquisas que vêm sendo realizadas para extensão de sua vida de prateleira e obtenção de produtos que mantenham o máximo possível suas características sensoriais originais.

  7. Digital design and verilog HDL fundamentals

    CERN Document Server

    Cavanagh, Joseph

    2011-01-01

    Comprehensive and self contained, this tutorial covers the design of a plethora of combinational and sequential logic circuits using conventional logic design and Verilog HDL. Number systems and number representations are presented along with various binary codes. Several advanced topics are covered, including functional decomposition and iterative networks. A variety of examples are provided for combinational and sequential logic, computer arithmetic, and advanced topics such as Hamming code error correction. Constructs supported by Verilog are described in detail. All designs are continued to completion. Each chapter includes numerous design issues of varying complexity to be resolved by the reader.

  8. Therapeutic applications of reconstituted HDL: When structure meets function.

    Science.gov (United States)

    Darabi, Maryam; Guillas-Baudouin, Isabelle; Le Goff, Wilfried; Chapman, M John; Kontush, Anatol

    2016-01-01

    Reconstituted forms of HDL (rHDL) are under development for infusion as a therapeutic approach to attenuate atherosclerotic vascular disease and to reduce cardiovascular risk following acute coronary syndrome and ischemic stroke. Currently available rHDL formulations developed for clinical use contain apolipoprotein A-I (apoA-I) and one of the major lipid components of HDL, either phosphatidylcholine or sphingomyelin. Recent data have established that quantitatively minor molecular constituents of HDL particles can strongly influence their anti-atherogenic functionality. Novel rHDL formulations displaying enhanced biological activities, including cellular cholesterol efflux, may therefore offer promising prospects for the development of HDL-based, anti-atherosclerotic therapies. Indeed, recent structural and functional data identify phosphatidylserine as a bioactive component of HDL; the content of phosphatidylserine in HDL particles displays positive correlations with all metrics of their functionality. This review summarizes current knowledge of structure-function relationships in rHDL formulations, with a focus on phosphatidylserine and other negatively-charged phospholipids. Mechanisms potentially underlying the atheroprotective role of these lipids are discussed and their potential for the development of HDL-based therapies highlighted. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. HDL Cholesterol and Risk of Type 2 Diabetes

    DEFF Research Database (Denmark)

    Haase, Christiane L; Tybjærg-Hansen, Anne; Nordestgaard, Børge G

    2015-01-01

    Observationally, low levels of HDL cholesterol are consistently associated with increased risk of type 2 diabetes. Therefore, plasma HDL cholesterol increasing has been suggested as a novel therapeutic option to reduce the risk of type 2 diabetes. Whether levels of HDL cholesterol are causally...... associated with type 2 diabetes is unknown. In a prospective study of the general population (n = 47,627), we tested whether HDL cholesterol-related genetic variants were associated with low HDL cholesterol levels and, in turn, with an increased risk of type 2 diabetes. HDL cholesterol-decreasing gene scores...... and allele numbers associated with up to -13 and -20% reductions in HDL cholesterol levels. The corresponding theoretically predicted hazard ratios for type 2 diabetes were 1.44 (95% CI 1.38-1.52) and 1.77 (1.61-1.95), whereas the genetic estimates were nonsignificant. Genetic risk ratios for type 2 diabetes...

  10. Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and coronary artery disease

    Directory of Open Access Journals (Sweden)

    Uint Luciana

    2003-01-01

    Full Text Available OBJECTIVE: The aim of this study was to verify whether HDL particles isolated from patients with coronary artery disease (CAD and low HDL-C had diminished ability to promote cholesterol efflux from cultured cells compared with HDL isolated from subjects without CAD and with normal HDL-C. METHODS: Smooth muscle cells isolated from human aortas cultured and radiolabeled with ³H-cholesterol were loaded with cholesterol and incubated with increasing concentrations of HDL isolated from 13 CAD patients with low HDL-C (CAD group or from 5 controls without CAD (C group. Efflux of cellular cholesterol was measured by cellular depletion of radiolabeled cholesterol and by the appearance of ³H-cholesterol into experimental medium expressed as a percentage of total labeled cholesterol. RESULTS: Cholesterol efflux increased with the amount of HDL present in the medium, and no difference was found between groups at various HDL protein concentrations: efflux was 28 ± 6.3% (C and 25.5 ± 8.9% (CAD with 25 mg/mL; 34 ± 4.3% (C and 31.9 ± 6.6% (CD with 50 mg/mL and 39.5 ± 3.5% (C and 37.1 ± 4.4% (CAD with 100 mg/mL, HDL. CONCLUSION: Because the HDL fraction of CAD patients with low HDL-C have normal ability to extract cholesterol from cells of the vessel wall, it is suggested that low HDL-C atherogenicity should be ascribed to diminished concentrations of HDL particles rather than to the qualitative properties of the HDL fraction.

  11. Aspectos tecnológicos de alimentos funcionais contendo probióticos Technological aspects of functional foods containing probiotics

    Directory of Open Access Journals (Sweden)

    Maricê Nogueira de Oliveira

    2002-03-01

    Full Text Available Os alimentos funcionais constituem hoje prioridade de pesquisa em todo mundo com a finalidade de elucidar as propriedades e os efeitos que estes produtos podem apresentar na promoção da saúde. As bactérias probióticas são microrganismos vivos que, quando consumidos, exercem efeitos benéficos sobre o hospedeiro conferindo propriedades à microbiota endógena. Algumas propriedades benéficas atribuídas às culturas probióticas necessitam de estudos mais controlados para serem definitivamente esclarecidas. Neste artigo são enfocados os aspectos tecnológicos dos probióticos, os efeitos associados ao consumo de produtos contendo probióticos e as principais cepas empregadas. São apresentados resultados experimentais originais para ilustrar os aspectos tecnológicos da fabricação de alimentos contendo probióticos buscando descrever suas limitações e alternativas.Functional food science is being considered priority of research nowadays and studies are directed towards attempts to elucidate their proprieties and effects in promoting health. Probiotics are viable microbial dietary supplements that have beneficial effects over the health of the host by means of modulation of the intestinal microflora. Some beneficial properties attributed to probiotic microorganisms still need more controlled studies to be definitely established. This article deals with technology aspects related to probiotics, the effects associated with the consumption of food products containing these microorganisms and the main strains employed for that purpose. Experimental data are also presented in order to illustrate technological aspects of the manufacture of food products containing probiotics, intending to describe their limitations and alternatives.

  12. Astaxanthin: structural and functional aspects Astaxantina: aspectos estruturais e funcionais

    Directory of Open Access Journals (Sweden)

    Larissa Mont'Alverne Jucá Seabra

    2010-12-01

    Full Text Available Astaxanthin, a carotenoid belonging to the xanthophyll class, has stirred great interest due to its antioxidant capacity and its possible role in reducing the risk of some diseases. Astaxanthin occurs naturally in microalgae, such as Haematococcus pluvialis and the yeast Phaffia rhodozyma, and has also been considered to be the major carotenoid in salmon and crustaceans. Shrimp processing waste, which is generally discarded, is also an important source of astaxanthin. The antioxidant activity of astaxanthin has been observed to modulate biological functions related to lipid peroxidation, having beneficial effects on chronic diseases such as cardiovascular disease, macular degeneration and cancer. Researches have shown that both astaxanthin obtained from natural sources and its synthetic counterpart produce satisfactory effects, but studies in humans are limited to natural sources. There is no established nutritional recommendation regarding astaxanthin daily intake but most studies reported beneficial results from a daily intake of 4mg. Thus, this review discusses some aspects of the carotenoid astaxanthin, highlighting its chemical structure and antioxidant activity, and some studies that report its use in humans.A astaxantina, carotenóide pertencente à classe das xantofilas, tem despertado grande interesse devido à sua capacidade antioxidante e possível papel na redução de risco de algumas doenças. A astaxantina pode ser encontrada naturalmente em microalgas como Haematococcus pluvialis e na levedura Phaffia rhodozyma como também tem sido considerada principal carotenóide em salmão e crustáceos. Os resíduos do processamento de camarão, geralmente descartados, são também importante fonte de astaxantina. A atividade antioxidante da astaxantina tem demonstrado importante função na modulação de funções biológicas relacionadas à peroxidação lipídica, desempenhando efeitos benéficos em doenças crônicas como doen

  13. ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level

    Directory of Open Access Journals (Sweden)

    Kexiu Song

    2014-01-01

    Full Text Available HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. SR-BI mediates the selective uptake of HDL-C. SR-BI knockout diminishes but does not completely block the transport of HDL; other receptors may be involved. Ectopic ATP synthase β-chain in hepatocytes has been previously characterized as an apoA-I receptor, triggering HDL internalization. This study was undertaken to identify the overexpression of ectopic ATP synthase β-chain on DIL-HDL uptake in primary hepatocytes in vitro and on plasma HDL levels in SR-BI knockout mice. Human ATP synthase β-chain cDNA was delivered to the mouse liver by adenovirus and GFP adenovirus as control. The adenovirus-mediated overexpression of β-chain was identified at both mRNA and protein levels on mice liver and validated by its increasing of DiL-HDL uptake in primary hepatocytes. In response to hepatic overexpression of β-chain, plasma HDL-C levels and cholesterol were reduced in SR-BI knockout mice, compared with the control. The present data suggest that ATP synthase β-chain can serve as the endocytic receptor of HDL, and its overexpression can reduce plasma HDL-C.

  14. New drugs for HDL-C disorders: the beginning.

    Science.gov (United States)

    Duong, MyNgan; Nicholls, Stephen J

    2014-01-01

    For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.

  15. ApoE-containing HDL and the development of atherosclerosis

    Directory of Open Access Journals (Sweden)

    Zbigniew Zdrojewski

    2015-06-01

    Full Text Available The current state of knowledge about the role of high density lipoproteins (HDL indicates that their anti-atherogenic function is mainly related to the effectiveness of their actions (mostly to the participation in reverse cholesterol transport from tissues to liver rather than the concentration of HDL itself. HDLs are highly heterogeneous in their structure, lipid and protein composition and metabolic pathways and individual HDL subpopulations differ in their biological activity and effectiveness of anti-atherogenic actions. Apolipoproteins play a key role in HDL metabolism, therefore their presence in lipoproteins is one of the main criterion for HDL classification. According to this criterion HDLs containing apolipoprotein E, called HDL-apoE, are distinguished. Although the anti-atherogenic role of apo E has been demonstrated in many scientific reports, understanding of the mechanisms of formation, transformation and the role of HDL-apoE is still the aim of intense research. The results of epidemiological studies are inconclusive; some of them have demonstrated that high HDL- -apoE concentration has been associated with lower risk of developing coronary heart disease (CHD, while other studies have shown that high levels of HDL-apoE has been an independent risk factor for cardiovascular events and positively correlated with other risk factors for CHD.

  16. Endothelial lipase is a major determinant of HDL level

    Energy Technology Data Exchange (ETDEWEB)

    Ishida, Tatsuro; Choi, Sungshin; Kundu, Ramendra K.; Hirata, Ken-Ichi; Rubin, Edward M.; Cooper, Allen D.; Quertermous, Thomas

    2003-01-30

    For the past three decades, epidemiologic studies have consistently demonstrated an inverse relationship between plasma HDL cholesterol (HDL-C) concentrations and coronary heart disease (CHD). Population-based studies have provided compelling evidence that low HDL-C levels are a risk factor for CHD, and several clinical interventions that increased plasma levels of HDL-C were associated with a reduction in CHD risk. These findings have stimulated extensive investigation into the determinants of plasma HDL-C levels. Turnover studies using radiolabeled apolipoprotein A-I, the major protein component of HDL, suggest that plasma HDL-C concentrations are highly correlated with the rate of clearance of apolipoprotein AI. However, the metabolic mechanisms by which HDL are catabolized have not been fully defined. Previous studies in humans with genetic deficiency of cholesteryl ester transfer protein, and in mice lacking the scavenger receptor BI (SR-BI), have demonstrated that these proteins participate in the removal of cholesterol from HDL, while observations in individuals with mutations in hepatic lipase indicate that this enzyme hydrolyzes HDL triglycerides. In this issue of the JCI, reports from laboratories of Tom Quertermous and Dan Rader now indicate that endothelial lipase (LIPG), a newly identified member of the lipase family, catalyzes the hydrolysis of HDL phospholipids and facilitates the clearance of HDL from the circulation. Endothelial lipase was initially cloned by both of these laboratories using entirely different strategies. Quertermous and his colleagues identified endothelial lipase as a transcript that was upregulated in cultured human umbilical vein endothelial cells undergoing tube formation, whereas the Rader group cloned endothelial lipase as a transcript that was upregulated in the human macrophage-like cell line THP-1 exposed to oxidized LDL. Database searches revealed that endothelial lipase shows strong sequence similarity to lipoprotein

  17. UMA PROPOSTA DE RELAÇÃO DE REQUISITOS FUNCIONAIS PARA UM SOFTWARE DE APOIO AO PROCESSO DE INTELIGÊNCIA

    Directory of Open Access Journals (Sweden)

    Fábio Luiz de Carvalho Rios

    Full Text Available Com o aumento da competição, estabeleceu-se a necessidade pelo acompanhamento do que os concorrentes estão fazendo e o que os clientes estão querendo. No Brasil, desde o início dos anos 2000, surgiram com maior ênfase metodologias que vão ao encontro deste olhar para o ambiente externo, denominadas metodologias de inteligência. São inúmeras, e se propõem a apoiar as organizações no processo de obtenção e uso de informações. Com a Internet, cada vez mais informações estão disponíveis para proporcionar o acompanhamento do que está acontecendo em cada um dos ambientes de competição onde as organizações estão inseridas. Desta forma, levando-se em consideração as metodologias de inteligência disponíveis e as premissas sobre grandes volumes de informações para acompanhamento dos ambientes de competição, faz sentido imaginar que um software possa contribuir neste cenário. Entretanto, quais requisitos funcionais um software de apoio ao processo de inteligência deveria ter? Esta é a principal questão que este trabalho busca responder. Através de extensa pesquisa bibliográfica na área de administração e entrevistas em profundidade com especialistas e profissionais em inteligência, foi possível identificar funcionalidades para, ao final deste estudo, propor uma relação de requisitos funcionais de software capaz de contribuir para este importante processo adotado nas principais organizações brasileiras.

  18. Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

    Science.gov (United States)

    Huang, Ying; Wu, Zhiping; Riwanto, Meliana; Gao, Shengqiang; Levison, Bruce S.; Gu, Xiaodong; Fu, Xiaoming; Wagner, Matthew A.; Besler, Christian; Gerstenecker, Gary; Zhang, Renliang; Li, Xin-Min; DiDonato, Anthony J.; Gogonea, Valentin; Tang, W.H. Wilson; Smith, Jonathan D.; Plow, Edward F.; Fox, Paul L.; Shih, Diana M.; Lusis, Aldons J.; Fisher, Edward A.; DiDonato, Joseph A.; Landmesser, Ulf; Hazen, Stanley L.

    2013-01-01

    Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein–associated (HDL-associated) proteins mechanistically linked to inflammation, oxidant stress, and atherosclerosis. MPO is a source of ROS during inflammation and can oxidize apolipoprotein A1 (APOA1) of HDL, impairing its atheroprotective functions. In contrast, PON1 fosters systemic antioxidant effects and promotes some of the atheroprotective properties attributed to HDL. Here, we demonstrate that MPO, PON1, and HDL bind to one another, forming a ternary complex, wherein PON1 partially inhibits MPO activity, while MPO inactivates PON1. MPO oxidizes PON1 on tyrosine 71 (Tyr71), a modified residue found in human atheroma that is critical for HDL binding and PON1 function. Acute inflammation model studies with transgenic and knockout mice for either PON1 or MPO confirmed that MPO and PON1 reciprocally modulate each other’s function in vivo. Further structure and function studies identified critical contact sites between APOA1 within HDL, PON1, and MPO, and proteomics studies of HDL recovered from acute coronary syndrome (ACS) subjects revealed enhanced chlorotyrosine content, site-specific PON1 methionine oxidation, and reduced PON1 activity. HDL thus serves as a scaffold upon which MPO and PON1 interact during inflammation, whereupon PON1 binding partially inhibits MPO activity, and MPO promotes site-specific oxidative modification and impairment of PON1 and APOA1 function. PMID:23908111

  19. Reference intervals for serum total cholesterol, HDL cholesterol and ...

    African Journals Online (AJOL)

    Reference intervals of total cholesterol, HDL cholesterol and non-HDL cholesterol concentrations were determined on 309 blood donors from an urban and peri-urban population of Botswana. Using non-parametric methods to establish 2.5th and 97.5th percentiles of the distribution, the intervals were: total cholesterol 2.16 ...

  20. Hdl-Cholesterol Et Les Autres Facteurs De Risque Cardio ...

    African Journals Online (AJOL)

    Ceci permettra de corriger d'éventuelles dyslipidémies et de prévenir les maladies cardiovasculaires. Mots clés : HDL-Cholestérol, facteurs de risques cardiovasculaires, noir africain, Togo. Objectives: To determine the frequency of cardiovascular risk according to HDL-C in cardiac milieu in black Africa, assess the impact ...

  1. Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.

    Science.gov (United States)

    Bartelt, Alexander; John, Clara; Schaltenberg, Nicola; Berbée, Jimmy F P; Worthmann, Anna; Cherradi, M Lisa; Schlein, Christian; Piepenburg, Julia; Boon, Mariëtte R; Rinninger, Franz; Heine, Markus; Toedter, Klaus; Niemeier, Andreas; Nilsson, Stefan K; Fischer, Markus; Wijers, Sander L; van Marken Lichtenbelt, Wouter; Scheja, Ludger; Rensen, Patrick C N; Heeren, Joerg

    2017-04-19

    Brown and beige adipocytes combust nutrients for thermogenesis and through their metabolic activity decrease pro-atherogenic remnant lipoproteins in hyperlipidemic mice. However, whether the activation of thermogenic adipocytes affects the metabolism and anti-atherogenic properties of high-density lipoproteins (HDL) is unknown. Here, we report a reduction in atherosclerosis in response to pharmacological stimulation of thermogenesis linked to increased HDL levels in APOE*3-Leiden.CETP mice. Both cold-induced and pharmacological thermogenic activation enhances HDL remodelling, which is associated with specific lipidomic changes in mouse and human HDL. Furthermore, thermogenic stimulation promotes HDL-cholesterol clearance and increases macrophage-to-faeces reverse cholesterol transport in mice. Mechanistically, we show that intravascular lipolysis by adipocyte lipoprotein lipase and hepatic uptake of HDL by scavenger receptor B-I are the driving forces of HDL-cholesterol disposal in liver. Our findings corroborate the notion that high metabolic activity of thermogenic adipocytes confers atheroprotective properties via increased systemic cholesterol flux through the HDL compartment.

  2. Antioxidant activity of high-density lipoprotein (HDL) using different ...

    African Journals Online (AJOL)

    HDL is a potent antioxidant in terms of inhibition of lipid peroxidation, ROS production and LDL oxidation. These may to some extent add to the antiatherogenic beyond reverse-cholesterol transport properties of HDL. Keywords: high-density lipoprotein; reverse cholesterol transport; apolipoprotein A1; antioxidant; in vitro.

  3. HDL as a drug and nucleic acid delivery vehicle

    Directory of Open Access Journals (Sweden)

    Andras G Lacko

    2015-10-01

    Full Text Available This review is intended to evaluate the research findings and potential clinical applications of drug transport systems, developed based on the concepts of the structure/function and physiological role(s of high density lipoprotein=type nanoparticles. These macromolecules provide targeted transport of cholesteryl esters (a highly lipophilic payload in their natural/physiological environment. The property of accommodating highly water insoluble constituents in their core region enables HDL type nanoparticles to effectively transport hydrophobic drugs upon intravenous administration. Even though the application of reconstituted HDL in the treatment of a number of diseases is reviewed, the primary focus is on the application of HDL type drug delivery agents in cancer chemotherapy. The use of both native and synthetic HDL as drug delivery agents are compared to evaluate their respective potentials for commercial and clinical development. The current status and future perspectives for HDL type nanoparticles are discussed, including current obstacles and future applications in therapeutics.

  4. The pleiotropic role of HDL in autoimmune diseases.

    Science.gov (United States)

    Parra, Sandra; Castro, Antoni; Masana, Luis

    2015-01-01

    As is widely known, the classic function of HDL is reverse cholesterol transport (RCT), thus removing cholesterol from peripheral tissues. Early epidemiological studies, such as Framingham's, stated that increased HDL levels were associated with a significant decrease in relative risk for cardiovascular disease (CVD) mortality. However, those with heightened expectations in recent years for the development of therapeutic targets to increase HDL levels have been disappointed, because efforts have demonstrated the opposite effect on cardiovascular and global mortality. However, in contrast, studies have highlighted the complexity and the intriguing role of HDL in different pathological conditions, such as infections, neoplasms, and autoimmune diseases. In this review an attempt is made to summarize some biological pathways that link HDL function with the immune system, and its possible clinical repercussions in autoimmune diseases. Copyright © 2014 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.

  5. Propriedades funcionais “in vitro” e “in vivo” de alhos frescos e processados

    OpenAIRE

    Silva, Ester Yoshie Yosino da

    2011-01-01

    O alho (Allium sativum L.) possui 33 compostos organossulfurados que variam de acordo com o processamento utilizado e diferentes condições de estocagem. A alicina é o composto ativo mais comum do alho, representando cerca de 70% dos compostos sulfurados presentes neste bulbo. Este estudo teve como objetivo determinar a influência do processamento e armazenamento nas propriedades físico-qumícas e funcionais em diferentes cultivares de alho (estudo “in vitro”) e avaliar os efeitos fisiológicos ...

  6. Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome.

    Science.gov (United States)

    Rached, Fabiana; Santos, Raul D; Camont, Laurent; Miname, Marcio H; Lhomme, Marie; Dauteuille, Carolane; Lecocq, Sora; Serrano, Carlos V; Chapman, M John; Kontush, Anatol

    2014-12-01

    To evaluate functional and compositional properties of HDL in subjects from a kindred of genetic apoA-I deficiency, two homozygotes and six heterozygotes, with a nonsense mutation at APOA1 codon -2, Q[-2]X, were recruited together with age- and sex-matched healthy controls (n = 11). Homozygotes displayed undetectable plasma levels of apoA-I and reduced levels of HDL-cholesterol (HDL-C) and apoC-III (5.4% and 42.6% of controls, respectively). Heterozygotes displayed low HDL-C (21 ± 9 mg/dl), low apoA-I (79 ± 24 mg/dl), normal LDL-cholesterol (132 ± 25 mg/dl), and elevated TG (130 ± 45 mg/dl) levels. Cholesterol efflux capacity of ultracentrifugally isolated HDL subpopulations was reduced (up to -25%, P < 0.01, on a glycerophospholipid [GP] basis) in heterozygotes versus controls. Small, dense HDL3 and total HDL from heterozygotes exhibited diminished antioxidative activity (up to -48%, P < 0.001 on a total mass basis) versus controls. HDL subpopulations from both homozygotes and heterozygotes displayed altered chemical composition, with depletion in apoA-I, GP, and cholesteryl ester; enrichment in apoA-II, free cholesterol, and TG; and altered phosphosphingolipidome. The defective atheroprotective activities of HDL were correlated with altered lipid and apo composition. These data reveal that atheroprotective activities of HDL particles are impaired in homozygous and heterozygous apoA-I deficiency and are intimately related to marked alterations in protein and lipid composition. Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc.

  7. Autoimmune Lymphoproliferative Syndrome: A Rare Cause of Disappearing HDL Syndrome

    Directory of Open Access Journals (Sweden)

    Swetha Sriram

    2016-01-01

    Full Text Available The term disappearing HDL syndrome refers to development of severe high density lipoprotein cholesterol (HDL-C deficiency in noncritically ill patients with previously normal HDL-C and triglyceride levels. Autoimmune lymphoproliferative syndrome (ALPS is a disorder of the immune system due to an inability to regulate lymphocyte homeostasis resulting in lymphadenopathy and hepatosplenomegaly. We describe a 17-year-old boy who was evaluated in the lipid clinic for history of undetectable or low HDL-C and low density lipoprotein cholesterol (LDL-C levels. Past medical history was significant for ALPS IA diagnosed at 10 years of age when he presented with bilateral cervical adenopathy. He was known to have a missense mutation in one allele of the FAS protein extracellular domain consistent with ALPS type 1A. HDL-C and LDL-C levels had been undetectable on multiple occasions, though lipids had not been measured prior to the diagnosis of ALPS. He had been receiving sirolimus for immunosuppression. The HDL-C and LDL-C levels correlated with disease activity and improved to normal levels during times when the activity of ALPS was controlled. This case highlights the importance of considering ALPS as a cause of low HDL-C and LDL-C levels in a child with evidence of lymphoproliferation.

  8. Propriedades funcionais-digestivas e nutricionais de polpa-refinada de maçã Digestive-functional and nutritional properties of refined apple pomace

    Directory of Open Access Journals (Sweden)

    Dorivaldo da Silva Raupp

    2000-09-01

    Full Text Available Propriedades funcionais-digestivas e nutricionais da polpa-refinada-desidratada de maçã (PRM foram avaliadas em ratos Wistar, tendo como padrão de fibra o farelo de trigo (FT. A PRM apresentou 91,91% de fibra alimentar/dietária, mais que o dobro do FT (43,69%, sendo 82,27% de fração insolúvel e 9,64% da fração solúvel; 8,20% de proteínas; 0,57% de lipídeos; 2,04% de cinzas (minerais; e ausência de carboidratos digestíveis. A incorporação na dieta dos ratos de PRM ou do padrão FT em proporções de 5%, 15% ou 25% produziu, nos animais, efeitos funcionais-digestivos e nutricionais próprios de fibra alimentar insolúvel. Na concentração de 5% (PRM e FT forneceram 4,6% e 2,2% de fibra alimentar, respectivamente as duas fontes de fibra produziram, com exceção da densidade de fezes seca, efeitos semelhantes. No entanto, em concentrações de 15% ou 25%, a PRM resultou em mais defecações, maior peso de fezes seca e densidade, porém, produziu fezes seca de menor volume. Com base no resultado da pesquisa, bem como na quantidade industrial disponível, conclui-se que a "polpa-refinada" de maçã poderá constituir-se em fonte alternativa potencial de fibra alimentar para a formulação de alimentos para consumo em dieta normal, mas, principalmente para alimentos especiais que devem apresentar propriedades funcionais-digestivas relacionadas à fibra alimentar.This study aimed to determine some digestive-functional and nutritional properties from dried-refined apple pomace (AP. Wheat bran (WB, a conventional dietary fiber source currently used in human nutrition, was considered as a standard for comparison. Total dietary fiber, including the insoluble and soluble fractions of AP were 91.91%, 82.27% and 9.64%, respectively. Other nutrients were protein (8.20%, lipid (0.57% and minerals (2.04%. Dietary fiber contents in standard WB was 43.69%, a value less than a half of AP. Digestive-functional and nutritional properties of each AP

  9. Characterization of antioxidant/anti-inflammatory properties and apoA-I-containing subpopulations of HDL from family subjects with monogenic low HDL disorders

    NARCIS (Netherlands)

    Daniil, Georgios; Phedonos, Alexia A. P.; Holleboom, Adriaan G.; Motazacker, Mohammad Mahdi; Argyri, Letta; Kuivenhoven, Jan Albert; Chroni, Angeliki

    2011-01-01

    Background: Genetic factors regulate both high-density lipoprotein (HDL) levels and functionality, thus affecting HDL antiatherogenic properties. We characterized the HDL antioxidant/anti-inflammatory properties and apoA-I-containing subpopulations in families with monogenic low HDL disorders.

  10. HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk.

    Directory of Open Access Journals (Sweden)

    Eliane Soler Parra

    Full Text Available Misclassification of patients as low cardiovascular risk (LCR remains a major concern and challenges the efficacy of traditional risk markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL size has been appointed as a potential risk marker. Hence, we investigate whether HDL size improves the predictive value of HDL-cholesterol in the identification of carotid atherosclerotic burden in individuals stratified to be at LCR.284 individuals (40-75 years classified as LCR by the current US guidelines were selected in a three-step procedure from primary care centers of the cities of Campinas and Americana, SP, Brazil. Apolipoprotein B-containing lipoproteins were precipitated by polyethylene glycol and HDL size was measured by dynamic light scattering (DLS technique. Participants were classified in tertiles of HDL size (8.22 nm. Carotid intima-media thickness (cIMT 8.22 nm was independently associated with low cIMT in either unadjusted and adjusted models for age, gender and Homeostasis Model Assessment 2 index for insulin sensitivity, ethnicity and body mass index (Odds ratio 0.23; 95% confidence interval 0.07-0.74, p = 0.013.The mean HDL size estimated with DLS constitutes a better predictor for subclinical carotid atherosclerosis than the conventional measurements of plasma HDL-cholesterol in individuals classified as LCR.

  11. HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk.

    Science.gov (United States)

    Parra, Eliane Soler; Panzoldo, Natalia Baratella; Zago, Vanessa Helena de Souza; Scherrer, Daniel Zanetti; Alexandre, Fernanda; Bakkarat, Jamal; Nunes, Valeria Sutti; Nakandakare, Edna Regina; Quintão, Eder Carlos Rocha; Nadruz, Wilson; de Faria, Eliana Cotta; Sposito, Andrei C

    2014-01-01

    Misclassification of patients as low cardiovascular risk (LCR) remains a major concern and challenges the efficacy of traditional risk markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL) size has been appointed as a potential risk marker. Hence, we investigate whether HDL size improves the predictive value of HDL-cholesterol in the identification of carotid atherosclerotic burden in individuals stratified to be at LCR. 284 individuals (40-75 years) classified as LCR by the current US guidelines were selected in a three-step procedure from primary care centers of the cities of Campinas and Americana, SP, Brazil. Apolipoprotein B-containing lipoproteins were precipitated by polyethylene glycol and HDL size was measured by dynamic light scattering (DLS) technique. Participants were classified in tertiles of HDL size (8.22 nm). Carotid intima-media thickness (cIMT) 8.22 nm was independently associated with low cIMT in either unadjusted and adjusted models for age, gender and Homeostasis Model Assessment 2 index for insulin sensitivity, ethnicity and body mass index (Odds ratio 0.23; 95% confidence interval 0.07-0.74, p = 0.013). The mean HDL size estimated with DLS constitutes a better predictor for subclinical carotid atherosclerosis than the conventional measurements of plasma HDL-cholesterol in individuals classified as LCR.

  12. Engenharia de anticorpos na busca por fragmentos funcionais para insumos de diagnóstico e aplicações terapêuticas

    Directory of Open Access Journals (Sweden)

    Michelle Suelen da Silva Morais

    2014-09-01

    Full Text Available Anticorpos, agentes empregados no desenvolvimento de pesquisas biomédicas, no diagnóstico e na terapêutica, possuem elevada capacidade de interação aos mais variados ligantes, Estruturalmente são heterotetrameros constituídos por duas cadeias leves e duas cadeias pesadas com massa molecular de aproximadamente 150 kDa, Visando melhorar as características farmacocinéticas e minimizar possíveis reações adversas desencadeadas por imunoglobulinas de origem não humana, a engenharia molecular de anticorpos vem obtendo fragmentos de anticorpos como porções Fab, F(ab’2, scFv e Fv, Em adição aos anticorpos convencionais, camelídeos produzem imunoglobulinas funcionais desprovidas de cadeia leve, onde o domínio variável da cadeia pesada, denominado VHH ou nanocorpo, é responsável pelo reconhecimento antigênico, Apresentando características adequadas ao desenvolvimento de fármacos com alta capacidade de neutralização, fragmentos VHHs vêm sendo propostos para uso em imunoterapia passiva ou em drug-delivery, No diagnóstico esses fragmentos podem ser aplicados na construção de biosensores ou na imagiologia, atuando na detecção de células cancerígenas, no monitoramento de tumores ou em alterações celulares.

  13. Evaluation of acidic functional monomers with spacer chains with different hydrophilicities and lengths = : Avaliação de monômeros funcionais ácidos com cadeias espaçadoras de diferentes hidrofilias e comprimentos

    OpenAIRE

    Victor Pinheiro Feitosa

    2013-01-01

    Resumo: O objetivo neste estudo foi avaliar o efeito da cadeia espaçadora (comprimento e polaridade) de cinco monômeros funcionais fosfatados, MEP (dois carbonos), MDP (dez carbonos), MDDP (doze carbonos), MTEP (cadeia mais hidrófila) e CAP-P (cadeia com hidrofilia intermediária) sobre a união química com dentina e cálcio, as propriedades físico-químicas e a adesão à dentina. Este estudo foi separado em 3 Capítulos. No Capítulo 1 foi verificada a influência da cadeia espaçadora de monômeros f...

  14. The WWOX Gene Modulates HDL and Lipid Metabolism

    Science.gov (United States)

    Iatan, Iulia; Choi, Hong Y.; Ruel, Isabelle; Linga Reddy, M.V. Prasad; Kil, Hyunsuk; Lee, Jaeho; Abu Odeh, Mohammad; Salah, Zaidoun; Abu-Remaileh, Muhannad; Weissglas-Volkov, Daphna; Nikkola, Elina; Civelek, Mete; Awan, Zuhier; Croce, Carlo M.; Aqeilan, Rami I.; Pajukanta, Päivi; Aldaz, C. Marcelo; Genest, Jacques

    2014-01-01

    Background Low high-density lipoprotein-cholesterol (HDL-C) constitutes a major risk factor for atherosclerosis. Recent studies from our group reported a genetic association between the WW domain-containing oxidoreductase (WWOX) gene and HDL-C levels. Here, through next-generation resequencing, in vivo functional studies and gene microarray analyses, we investigated the role of WWOX in HDL and lipid metabolism. Methods and Results Using next-generation resequencing of the WWOX region, we first identified 8 variants significantly associated and perfectly segregating with the low-HDL trait in two multi-generational French Canadian dyslipidemic families. To understand in vivo functions of WWOX, we used liver-specific Wwoxhep−/− and total Wwox−/− mice models, where we found decreased ApoA-I and ABCA1 levels in hepatic tissues. Analyses of lipoprotein profiles in Wwox−/−, but not Wwox hep−/− littermates, also showed marked reductions in serum HDL-C concentrations, concordant with the low-HDL findings observed in families. We next obtained evidence of a gender-specific effect in female Wwoxhep−/− mice, where an increase in plasma triglycerides and altered lipid metabolic pathways by microarray analyses were observed. We further identified a significant reduction in ApoA-I and LPL, and upregulation in Fas, Angptl4 and Lipg, suggesting that the effects of Wwox involve multiple pathways, including cholesterol homeostasis, ApoA-I/ABCA1 pathway, and fatty acid biosynthesis/triglyceride metabolism. Conclusions Our data indicate that WWOX disruption alters HDL and lipoprotein metabolism through several mechanisms and may account for the low-HDL phenotype observed in families expressing the WWOX variants. These findings thus describe a novel gene involved in cellular lipid homeostasis, which effects may impact atherosclerotic disease development. PMID:24871327

  15. Critérios de escolha alimentar : critério saúde/bem estar : alimentos funcionais

    OpenAIRE

    Moura, Ana Pinto de

    2011-01-01

    Neste documento (texto de apoio) considera-se a problemática do critério: Saúde nas escolhas alimentares do consumidor, particularizando a análise para o caso dos Alimentos Funcionais. Este documento deve ser lido em sintonia com os Slides sobe o mesmo tema.

  16. LCAT, HDL Cholesterol and Ischemic Cardiovascular Disease: A Mendelian Randomization Study of HDL Cholesterol in 54,500 Individuals

    DEFF Research Database (Denmark)

    Haase, Christiane L; Tybjærg-Hansen, Anne; Ali Qayyum, Abbas

    2012-01-01

    Background:Epidemiologically, high-density lipoprotein (HDL) cholesterol levels associate inversely with risk of ischemic cardiovascular disease. Whether this is a causal relation is unclear.Methods:We studied 10,281 participants in the Copenhagen City Heart Study (CCHS) and 50,523 participants...... in the Copenhagen General Population Study (CGPS), of which 991 and 1,693 participants, respectively, had developed myocardial infarction (MI) by August 2010. Participants in the CCHS were genotyped for all six variants identified by resequencing lecithin-cholesterol acyltransferase in 380 individuals. One variant......, S208T (rs4986970, allele frequency 4%), associated with HDL cholesterol levels in both the CCHS and the CGPS was used to study causality of HDL cholesterol using instrumental variable analysis.Results:Epidemiologically, in the CCHS, a 13% (0.21 mmol/liter) decrease in plasma HDL cholesterol levels...

  17. Os prejuízos funcionais de pessoas com transtorno de ansiedade social: uma revisão Functional impairment of persons with social anxiety disorder: a review

    Directory of Open Access Journals (Sweden)

    Luciene Vaccaro de Morais

    2008-01-01

    Full Text Available O transtorno de ansiedade social caracteriza-se pelo medo acentuado e persistente de situações sociais ou de desempenho, podendo influenciar a vida cotidiana dos portadores. Objetiva-se identificar, na literatura indexada, estudos empíricos com instrumentos de avaliação que abordem os prejuízos funcionais experimentados por pessoas com transtorno de ansiedade social no desempenho de atividades cotidianas e analisar as implicações de tais dificuldades. Procedeu-se a uma busca sistemática junto às bases de dados indexadas, identificando dez artigos, que foram agrupados em dois conjuntos: a os relativos à proposição de instrumentos de avaliação e análise das qualidades psicométricas (n = 4; e b os relativos ao impacto do transtorno de ansiedade social para a qualidade de vida e para as atividades cotidianas (n = 6. Os estudos psicométricos ressaltaram a pouca atenção dada a instrumentos validados para avaliar especificamente os prejuízos funcionais. Os trabalhos relativos ao impacto na qualidade de vida e nas atividades cotidianas constataram a presença de insatisfação com a vida e com a saúde em pacientes com transtorno de ansiedade social. A análise da literatura apontou para a importância da avaliação dos prejuízos funcionais do transtorno de ansiedade social no funcionamento cotidiano, por meio de medidas objetivas. Destaca-se a relevância de tais avaliações no planejamento e na intervenção de atividades voltadas ao transtorno de ansiedade social no contexto das práticas multidisciplinares de saúde mental.Social anxiety disorder is characterized by strong and persistent fear of social situations, impairing the daily life of affected people. The objective of the present work was to identify empirical studies involving instruments that assess the functional impairment experienced by persons with social anxiety disorder in the execution of daily activities and to analyze the implications of such difficulties. A

  18. Hypertriglyceridaemia, postprandial lipaemia and non-HDL cholesterol.

    Science.gov (United States)

    Stefanutti, Claudia; Labbadia, Giancarlo; Athyros, Vasilios G

    2014-01-01

    Maintaining total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels within healthy limits decreases the risk of atherosclerotic vascular disease (AVD) and cardiovascular (CV) events. The predictive value of elevated TG levels for coronary artery disease (CAD) seen in univariate analysis tends to disappear on multivariate analyses, especially when correction is made for HDL-C. The relationship between TG and HDL-C is complex and not fully understood. Hydrolysis of TG by lipoprotein lipase converts HDL subclass 3 to a larger lipoprotein enriched in both phospholipid and TG. This process occurs in postprandial lipaemia (PPL). An additional factor for the complex relationship between TGs and CV risk is that the lipoproteins which transport plasma TG (chylomicrons, very low density lipoproteins and their remnants) are heterogeneous particles. Therefore, they may differ in their level of atherogenicity. PPL is a physiological process during which plasma lipoproteins and their subclasses undergo variations in concentration and composition following consumption of food, particularly fatty food. "Postprandial hyperlipidaemia" is the quantitative/qualitative alteration of this normal process. These lipoprotein alterations could play a role in the development of CV disease (CVD). However, lipid levels used to evaluate CV risk are usually measured in the fasting state. This review focuses on TG, PPL, postprandial hyperlipidaemia and non-HDL-C, their relationships and potential predictive role in atherogenesis and CVD.

  19. Dorsalgias e incapacidades funcionais relacionadas ao trabalho: registros do sistema de informação de agravos de notificação (SINAN/DATASUS

    Directory of Open Access Journals (Sweden)

    Kionna Oliveira Bernardes Santos

    Full Text Available Resumo Introdução: dorsalgias e incapacidades são problemas de saúde do trabalhador com repercussões econômicas e sociais. Objetivo: descrever os casos notificados de dorsalgia e de incapacidade funcional no Brasil. Métodos: estudo de casuística das dorsalgias relacionadas ao trabalho registradas como Distúrbios Osteomusculares Relacionados ao Trabalho (DORT no Sistema de Informação de Agravos de Notificação (SINAN, Ministério da Saúde, no Brasil, de 2007 a 2012. Calcularam-se as frequências das variáveis sociodemográficas e ocupacionais e os coeficientes de incidência (CI para as dorsalgias e incapacidades permanentes. Resultados: foram registrados 8.172 casos de dorsalgias no período. O CI da dorsalgia foi 1,1 por 100.000 trabalhadores em 2007 e 1,9 por 100.000 em 2012 e o da incapacidade funcional relacionada ao trabalho foi 0,12 por 100.000 em 2007 e 0,10 por 100.000 em 2012. Trabalhadores de bens e serviços industriais e trabalhadores de serviços/vendedores de loja apresentaram os maiores percentuais para dorsalgias (54,4% e 20,7% e incapacidade funcional permanente (54,7% e 16,3%. Conclusões: O aumento das notificações das dorsalgias ocupacionais e a redução das incapacidades funcionais representam um avanço em relação ao reconhecimento, diagnóstico, notificação e atenção ao problema, mas continuam representando um desafio para a atenção à saúde dos trabalhadores.

  20. Antioxidative activity of high-density lipoprotein (HDL: Mechanistic insights into potential clinical benefit

    Directory of Open Access Journals (Sweden)

    Fernando Brites

    2017-12-01

    Antioxidative function of HDL can be impaired in several metabolic and inflammatory diseases. Structural and compositional anomalies in the HDL proteome and lipidome underlie such functional deficiency. Concomitant normalization of the metabolism, circulating levels, composition and biological activities of HDL particles, primarily those of small, dense HDL3, can constitute future therapeutic target.

  1. MOLECULAR DYNAMICS SIMULATION AND EXPERIMENTAL STUDIES OF GOLD NANOPARTICLE TEMPLATED HDL-LIKE NANOPARTICLES FOR CHOLESTEROL (POSTPRINT)

    Science.gov (United States)

    2016-12-21

    pharmaceutical industry have tried to develop HDL mimics for various therapeutic purposes.14,15 Studies have demonstrated that functional mimics of HDL...Ester Formation on HDL AuNP. The HDL AuNP and bilayer NP (HDL AuNP without apoA-I) were synthesized as previously described.17 After synthesis , HDL

  2. HIFSuite: Tools for HDL Code Conversion and Manipulation

    Directory of Open Access Journals (Sweden)

    Bombieri Nicola

    2010-01-01

    Full Text Available Abstract HIFSuite ia a set of tools and application programming interfaces (APIs that provide support for modeling and verification of HW/SW systems. The core of HIFSuite is the HDL Intermediate Format (HIF language upon which a set of front-end and back-end tools have been developed to allow the conversion of HDL code into HIF code and vice versa. HIFSuite allows designers to manipulate and integrate heterogeneous components implemented by using different hardware description languages (HDLs. Moreover, HIFSuite includes tools, which rely on HIF APIs, for manipulating HIF descriptions in order to support code abstraction/refinement and postrefinement verification.

  3. Políticas de saúde e alegações de propriedades funcionais e de saúde para alimentos no Brasil Health policies and functional property and health claims for food in Brazil

    Directory of Open Access Journals (Sweden)

    Paulo César Stringheta

    2007-06-01

    Full Text Available O trabalho estabelece a relação entre as diretrizes das políticas públicas de saúde brasileiras e os critérios adotados pela Anvisa para aprovação das alegações de propriedades funcionais e, ou, de saúde para alimentos e para substâncias bioativas e probióticos isolados. Comenta a legislação brasileira sobre alimentos com alegações de propriedades funcionais e, ou, de saúde, novos alimentos e substâncias bioativas e probióticos isolados, evidenciando a obrigatoriedade de registro destes produtos junto aos órgãos competentes. Apresenta as diretrizes da Política Nacional de Alimentação e Nutrição, Política Nacional de Promoção da Saúde, Guia Alimentar para a População Brasileira e Estratégia Global sobre Dieta, Atividade Física e Saúde da Organização Mundial de Saúde. Ressalta a convergência das diretrizes destas políticas que objetivam a redução das doenças crônicas não-transmissíveis na população através da promoção da alimentação saudável e da atividade física. Destaca as orientações direcionadas aos governos e à indústria para a implementação dessas medidas. Apresenta critérios de avaliação da base científica das alegações propostos por órgãos internacionais. Objetiva oferecer subsídios para o entendimento da influência da tecnologia de alimentos sobre a saúde pública e para o entendimento dos critérios adotados pela Anvisa, na avaliação das alegações de propriedades funcionais e de saúde.This article establishes the relationship between public health policies in Brazil and the criteria adopted by Anvisa for the approval of functional property claims and, or, of health for food and for bioactive substances and isolated products. It also comments on Brazilian Legislation about functional property claimed food and, or, on healthy claimed food, new foods, bioactive substances and isolated probiotics, emphasizing the obligation to registering such products before the

  4. marital status and occupation versus serum total cholesterol and hdl

    African Journals Online (AJOL)

    DR. AMIN

    Keywords: Occupation, Cholesterol, Kano, Serum Lipid. INTRODUCTION. Differences in serum HDL – CH and low density lipoprotein cholesterol (LDL – CH) levels between communities have been employed in explaining the postulated relationship that exist between serum lipoprotein levels and the incidence of coronary ...

  5. Plasma HDL cholesterol and risk of myocardial infarction

    DEFF Research Database (Denmark)

    Voight, Benjamin F; Peloso, Gina M; Orho-Melander, Marju

    2012-01-01

    High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendel...

  6. HDL-cholesterol reductions associated with adult growth hormone replacement.

    Science.gov (United States)

    Leese, G P; Wallymahmed, M; VanHeyningen, C; Tames, F; Wieringa, G; MacFarlane, I A

    1998-11-01

    To study the effects of human growth hormone (hGH) replacement on serum lipids and lipoprotein (a) (Lp(a)) concentrations. A randomized double blind placebo controlled trial for 6 months followed by an open trial where all patients were treated with hGH for a further 6 months. Treatment was with recombinant hGH given in a dose of 0.125U/kg/wk increasing to 0.25U/Kg/wk. Thirty two patients with growth hormone deficiency were recruited, but two withdrew because of side effects. Of the thirty patients (age 35.1 +/- 11.8 year; mean +/- SD) completing the study 13 of were assigned to the placebo group for six months and 17 to active treatment from the start. Fasting serum samples were analysed for total cholesterol, High density lipoprotein (HDL)-cholesterol, HDL-subfractions, triglycerides, lipoprotein (a) (Lp(a)) and IGF-1. LDL-cholesterol was calculated using the Friedewald formula. Compared to placebo, 6 months treatment with hGH therapy resulted in increased IGF-1 (37.6 +/- 4.1 vs. 14.0 +/- 2.2 nmol/l, P hGH was associated with a decrease in HDL-cholesterol concentration from baseline to 6 months (0.97 +/- 0.08 to 0.76 +/- 0.10 mmol/l P hGH can reduce serum HDL-cholesterol concentrations. Further investigation of this is required.

  7. Propriedades funcionais de concentrado protéico de feijão envelhecido

    Directory of Open Access Journals (Sweden)

    DONADEL Marta Elenita

    1999-01-01

    Full Text Available Avaliaram-se algumas propriedades funcionais de concentrados protéicos de feijão comum, variedade Carioca, envelhecido. Para acelerar o envelhecimento do feijão, armazenaram-se os grãos em estufa a 41ºC por 20, 30 e 40 dias, tomando-se o tempo zero (feijão novo como controle. Medidas do tempo de cozimento demonstraram que o armazenamento provocou o endurecimento dos grãos. Com o aumento do tempo de armazenamento dos grãos houve uma diminuição no conteúdo de proteínas nos concentrados protéicos obtidos por extração alcalina e posterior precipitação isoelétrica. As propriedades emulsificantes, espumantes, de absorção de água, de absorção de óleo e solubilidade das proteínas em função do pH foram avaliadas nos concentrados protéicos obtidos de grãos de feijão envelhecidos nos diferentes tempos de armazenamento e na amostra controle. O envelhecimento do feijão provocou uma melhora nessas propriedades. A solubilidade das proteínas dos concentrados em função do pH foi menor no intervalo de 4 a 5.

  8. Relation of Oxidative Stress and Impaired Fibrinolysis with HDL Biogenesis in Indonesian Men with Metabolic Syndrome

    Directory of Open Access Journals (Sweden)

    Ida Paulina Sormin

    2010-04-01

    Full Text Available BACKGROUND: Biogenesis of HDL involves factors that regulate the synthesis, intravascular remodeling, and catabolism of HDL. Disturbance of these factors can lead to low concentration of HDL-C. Metabolic syndrome (MetS is characterized by low concentration of high-density lipoprotein cholesterol (HDL-C. In MetS occur several pathological conditions including oxidative stress and impaired fibrinolysis, which contribute to the risk of atherosclerosis process. The correlation between oxidative stress and impaired fibrinolysis with HDL biogenesis dysfunction and its correlation with low concentration of HDL-C has not been well understood and therefore needs to be further investigated. METHODS: This study was an observational study with crosssectional design, involving 163 adult men, aged 25-60 years with metabolic syndrome. Concentration of apoA-1, prebeta-1 HDL, CETP, F2-isoprostan, PAI-1, and HDL-C were measured. The apo A1/HDL ratio indicated HDL maturation, whereas the CETP/HDL-C and CETP/TG ratios indicated HDL catabolism. RESULTS: The study showed that there were a positive correlation between PAI-1 with apoA1/HDL-C ratios (r=0.226, p=0.005 and a negative correlation with the CETP/TG ratios (r=-0.215, p=0.007, whereas F2-isoprostan did not have correlation with HDL biogenesis factors. CONCLUSIONS: We concluded that there was correlation between impaired fibrinolysis with decreased HDL maturation and there was increased HDL catabolism leading to low HDL-C concentration in men with metabolic syndrome. KEYWORDS: F2-isoprostan, PAI-1, apoA-1, prebeta-1 HDL, CETP, metabolic syndrome.

  9. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

    DEFF Research Database (Denmark)

    Zanoni, Paolo; Khetarpal, Sumeet A; Larach, Daniel B

    2016-01-01

    Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL......-C levels but, paradoxically, increased atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans remains unclear. Through targeted sequencing of coding regions of lipid-modifying genes in 328 individuals with extremely high plasma HDL-C levels, we identified a homozygote for a loss-of-function...

  10. High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study

    NARCIS (Netherlands)

    Arts, E.; Fransen, J.; Lemmers, H.; Stalenhoef, A.F.; Claessens-Joosten, L.; Riel, P. van; Popa, C.

    2012-01-01

    INTRODUCTION: Higher levels of high density lipoprotein (HDL) subfractions HDL3-chol and particularly HDL2-chol protect against cardiovascular disease (CVD), but inflammation reduces the HDL level and may impair its anti-atherogenic effect. Changed HDL composition through the impact of inflammation

  11. Prevalence of low HDL-cholesterol in patients with cardiovascular risk factors: The ECHOS (Etude du Cholesterol HDL en Observationnel) French Survey.

    Science.gov (United States)

    Farnier, M; Garnier, P; Yau, C; Dejager, S; Verpilleux, M P

    2006-10-01

    A low concentration of high-density lipoprotein-cholesterol (HDL-C) is an independent risk factor for cardiovascular heart disease (CHD), but little is known about the distribution of HDL-C in France. This study evaluated the prevalence of low HDL-C among a large French population (5232 patients) with other cardiovascular risk factors. Depending on the guidelines used, the prevalence of low HDL-C varied from 8.7% (cutoff value of 35 mg/dl) to 26.9% (National Cholesterol Education Program metabolic syndrome cutoff values). The prevalence of low HDL-C gradually increased with the number of associated risk factors. We identified three independent risk predictors for low HDL-C: hypertriglyceridaemia (HTG), abdominal obesity and gender. Overall, the frequency of HDL-C assessment was very high (>85%) and it was highest in patients with hypercholesterolaemia or a history of CHD. Risk factors more frequently associated with low HDL-C (i.e. HTG, abdominal obesity and type 2 diabetes) were not associated with a more frequent assessment of HDL-C. Our findings indicate that in France, the prevalence of low HDL-C remains relatively high, particularly for patients with obesity and HTG.

  12. Cholesterol Efflux Capacity and Subclasses of HDL Particles in Healthy Women Transitioning Through Menopause.

    Science.gov (United States)

    El Khoudary, Samar R; Hutchins, Patrick M; Matthews, Karen A; Brooks, Maria M; Orchard, Trevor J; Ronsein, Graziella E; Heinecke, Jay W

    2016-09-01

    Growing evidence challenges the concept that high-density lipoprotein-cholesterol (HDL-C) is cardioprotective after menopause. HDL particle concentration (HDL-P) and cholesterol efflux capacity (CEC) might be better predictors of cardiovascular risk. Quantify alterations in HDL-P and CEC during menopause, correlating those changes with alterations in estradiol (E2) and FSH. Longitudinal study of HDL metrics before and after menopause as indexed by the final menstrual period (FMP). Forty-six women, mean baseline age 47.1 years, 33% black, 67% white. HDL-P concentration (HDL-PIMA) by calibrated ion mobility analysis (IMA); macrophage CEC with cAMP-stimulated macrophages; ATP-binding cassette transporter A1 (ABCA1)-specific CEC with BHK cells expressing human ABCA1. After a median of 2.1 years since FMP, both HDL-C (P = .03) and HDL-PIMA (P = .01) increased, with a selective increase in large HDL-PIMA (P = .01), whereas sizes of medium and small HDL-PIMA were decreased (P changes were independent of race, body mass index, and time difference. Macrophage CEC and ABCA1-specific CEC increased after FMP (both P menopause (P = .04 and .009, respectively). Large HDL-PIMA and CEC increased significantly in the early phase of the menopausal transition. Whether patterns of these alterations differ in late postmenopause is unknown. Further exploration is needed to assess that and to determine whether the reported changes in HDL metrics associate with increased cardiovascular risk after menopause.

  13. Mechanism of transfer of LDL-derived free cholesterol to HDL subfractions in human plasma

    International Nuclear Information System (INIS)

    Miida, T.; Fielding, C.J.; Fielding, P.E.

    1990-01-01

    The transfer of [ 3 H]cholesterol in low-density lipoprotein (LDL) to different high-density lipoprotein (HDL) species in native human plasma was determined by using nondenaturing two-dimensional electrophoresis. Transfer from LDL had a t 1/2 at 37 degree C of 51 ± 8 min and an activation energy of 18.0 kCal mol -1 . There was unexpected specificity among HDL species as acceptors of LDL-derived labeled cholesterol. The largest fraction of the major α-migrating class (HDL 2b ) was the major initial acceptor of LDL-derived cholesterol. Kinetic analysis indicated a rapid secondary transfer from HDL 2b to smaller αHDL (particularly HDL 3 ) driven enzymatically by the lecithin-cholesterol acyltransferase reaction. Rates of transfer among αHDL were most rapid from the largest αHDL fraction (HDL 2b ), suggesting possible protein-mediated facilitation. Simultaneous measurements of the transport of LDL-derived and cell-derived isotopic cholesterol indicated that the former preferably utilized the αHDL pathyway, with little label in pre-βHDL. The same experiments confirmed earlier data that cell-derived cholesterol is preferentially channeled through pre-βHDL. The authors suggest that the functional heterogeneity of HDL demonstrated here includes the ability to independently process cell- and LDL-derived free cholesterol

  14. Effect of modified clays on the structure and functional properties of biofilms produced with zein Efeito das argilas modificadas na estrutura e propriedades funcionais de biofilmes produzidos com zeína

    Directory of Open Access Journals (Sweden)

    Luciana Lopes Tavares

    2012-06-01

    Full Text Available The purpose of this study was to evaluate changes in the structure and some functional properties of biofilms added with modified clays (Cloisite® 15A and Cloisite® 30B prepared by the casting method. The analysis of the microstructure of the films, scanning electron microscopy (SEM, Optical microscopy (MO, and Infrared Spectroscopy (FTIR indicated that the addition of clay in the films resulted in the formation of a heterogeneous microstructure, microcomposite or tactoid. Due to the formation of a microcomposite structure, functional properties of the films added with both clays such as opacity, solubility, and permeability to water vapor (PVA, were not better than those of the control film. Thus, it was concluded that although it is possible to produce a film added with modified clays using the casting method, it was not possible to obtain intercalation or exfoliation in a nanocomposite, which would result in improved functional properties.O propósito deste estudo foi avaliar mudanças na estrutura e em algumas propriedades funcionais de biofilmes de zeína adicionados de argilas modificadas (Cloisite® 15A e Cloisite® 30B elaborados pela técnica casting. Por meio do uso de técnicas de análise de microestrutura dos filmes, Microscopia Eletrônica de Varredura (MEV, Microscopia Ótica (MO e Espectroscopia no Infravermelho (FTIR, observou-se que os acréscimos de argilas resultaram na formação de uma microestrutura heterogênea, formando um microcompósito ou tactoide. Devido à formação da estrutura tipo tactoide, as propriedades funcionais de opacidade, solubilidade e permeabilidade ao vapor d'água (PVA, para os filmes adicionados de argilas, não foram melhores do que as obtidas para o filme controle. Assim, concluiu-se que é possível elaborar um filme adicionado de argilas modificadas usando a técnica casting, porém não foi possível obter intercalação ou esfoliação em nanocompósito, os quais resultariam em melhores

  15. Estratégias de enfrentamento, dificuldades funcionais e fatores associados em idosos institucionalizados Coping strategies, functional difficulties, and associated factors in institutionalized elderly

    Directory of Open Access Journals (Sweden)

    Analise de Souza Vivan

    2009-02-01

    Full Text Available O objetivo deste estudo é verificar as estratégias de enfrentamento utilizadas pelos idosos em face das dificuldades funcionais e a existência de associação entre o uso das estratégias e variáveis como sintomas depressivos, sexo, escolaridade, idade, estado civil e percepção da saúde. Participaram do estudo 103 idosos institucionalizados, que apresentavam necessidade de assistência em no mínimo uma atividade de vida diária. O delineamento foi transversal, com a utilização dos seguintes instrumentos: Ficha de Dados Pessoais, Escala de Atividades da Vida Diária, Breve Entrevista Internacional de Neuropsiquiatria Modificada, Mini-Exame do Estado Mental, Inventário de Estratégias de Coping e Escala de Depressão Geriátrica. As estratégias de enfrentamento mais utilizadas pela amostra foram a de autocontrole e resolução de problemas. Encontraram-se associações significativas entre as variáveis escolaridade e depressão. Os resultados da pesquisa sugerem que a avaliação das estratégias utilizadas em face de eventos estressores pode auxiliar na análise da situação e na adequação das estratégias escolhidas, ajudando também em processos de mudança no contexto clínico.The aim of this study was to analyze the strategies used by elderly people to cope with functional difficulties, and to investigate a possible association between such strategies and variables like depressive symptoms, gender, schooling, marital status, and self-perceived health. 103 institutionalized elderly individuals participated in the study. They required assistance for at least one activity of daily living. The study was cross-sectional and used the following indicators: Personal Data Chart, Activities of Daily Living Scale, Modified Mini International Neuropsychiatric Interview, Mini-Mental Examination, Coping Strategies Inventory, and Geriatric Depression Scale. The most widely used coping strategies in the sample were self-control and problem

  16. Apolipoproteins E and CIII interact to regulate HDL metabolism and coronary heart disease risk

    DEFF Research Database (Denmark)

    Morton, Allyson M; Koch, Manja; Mendivil, Carlos O

    2018-01-01

    BACKGROUND: Subspecies of HDL contain apolipoprotein E (apoE) and/or apoCIII. Both proteins have properties that could affect HDL metabolism. The relation between HDL metabolism and risk of coronary heart disease (CHD) is not well understood. METHODS: Eighteen participants were given a bolus...... infusion of [D3]L-leucine to label endogenous proteins on HDL. HDL was separated into subspecies containing apoE and/or apoCIII and then into 4 sizes. Metabolic rates for apoA-I in HDL subspecies and sizes were determined by interactive modeling. The concentrations of apoE in HDL that contain or lack apo......CIII were measured in a prospective study in Denmark including 1,949 incident CHD cases during 9 years. RESULTS: HDL containing apoE but not apoCIII is disproportionately secreted into the circulation, actively expands while circulating, and is quickly cleared. These are key metabolic steps in reverse...

  17. Estudo de correlação entre provas funcionais respiratórias e o teste de caminhada de seis minutos em pacientes portadores de doença pulmonar obstrutiva crônica

    Directory of Open Access Journals (Sweden)

    RODRIGUES SÉRGIO LEITE

    2002-01-01

    Full Text Available Introdução: A espirometria e a gasometria são largamente utilizadas na estimativa da limitação ventilatória e do prognóstico de pacientes portadores de doença pulmonar obstrutiva crônica. Entretanto, testes físicos funcionais, como o teste de caminhada de seis minutos (Tc6, têm surgido como complemento na avaliação dinâmica de portadores de doença pulmonar obstrutiva crônica. Objetivo: Determinar as correlações entre as provas funcionais respiratórias e o teste de caminhada de seis minutos em portadores de DPOC. Pacientes e métodos: 45 pacientes foram submetidos à coleta de história clínica e a exame físico completo realizado pela equipe médica do Serviço de Pneumologia do Hospital Universitário de Brasília. Em seguida, foi realizada a avaliação das variáveis espirométricas, gasométricas, das pressões respiratórias e o teste de caminhada de seis minutos (Tc6. Resultados: Observaram-se correlações positivas estatisticamente significativas (p < 0,05 das variáveis VEF1, PaO2, SpO2 e Pe máx em relação ao teste de caminhada de seis minutos. Conclusões: O teste de caminhada de seis minutos correlacionou-se de forma significativa (p < 0,05 e positiva e pode ser utilizado como instrumento alternativo na avaliação funcional do paciente portador de DPOC.

  18. Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population

    DEFF Research Database (Denmark)

    Frikke-Schmidt, Ruth; Nordestgaard, Børge G; Jensen, Gorm B

    2004-01-01

    Homozygosity for mutations in ABC transporter A1 (ABCA1) causes Tangier disease, a rare HDL-deficiency syndrome. Whether heterozygosity for genetic variation in ABCA1 also contributes to HDL cholesterol (HDL-C) levels in the general population is presently unclear. We determined whether mutations...

  19. HDL-LDL Ratio: A Significant Predisposition to the Onset of ...

    African Journals Online (AJOL)

    The significance of high-density lipoprotein/low density lipoprotein (HDL-LDL) ratio as a predisposing factor to the onset of atherogenesis has been studied. Standard enzymatic method using Cholesterol kit to extract cholesterol was used. HDL was analysed using standard HDL Kit and LDL concentration was derived by a ...

  20. Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans

    NARCIS (Netherlands)

    Brunham, Liam R.; Tietjen, Ian; Bochem, Andrea E.; Singaraja, Roshni R.; Franchini, Patrick L.; Radomski, Chris; Mattice, Maryanne; Legendre, Annick; Hovingh, G. Kees; Kastelein, John J. P.; Hayden, Michael R.

    2011-01-01

    The scavenger receptor class B, member 1 (SR-BI), is a key cellular receptor for high-density lipoprotein (HDL) in mice, but its relevance to human physiology has not been well established. Recently a family was reported with a mutation in the gene encoding SR-BI and high HDL cholesterol (HDL-C).

  1. PXR agonism decreases plasma HDL levels in ApoE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    Haan, W. de; Vries-van der Weij, J. de; Mol, I.M.; Hoekstra, M.; Romijn, J.A.; Jukema, J.W.; Havekes, L.M.; Princen, H.M.G.; Rensen, P.C.N.

    2009-01-01

    Pregnane X receptor (PXR) agonism has been shown to affect multiple steps in both the synthesis and catabolism of HDL, but its integrated effect on HDL metabolism in vivo remains unclear. The aim of this study was to evaluate the net effect of PXR agonism on HDL metabolism in ApoE*3-Leiden (E3L) and

  2. Alimentos funcionais com microalgas: nova fonte de pigmentos, antioxidantes e ácidos gordos ómega 3

    OpenAIRE

    Duarte, Diana Rita da Silva, 1986-

    2010-01-01

    Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2010 As microalgas são uma potencial fonte para a obtenção de variados compostos biologicamente activos (carotenóides, ácidos gordos, vitaminas e polissacáridos), com uma eficácia superior à verificada pelas tradicionais culturas vegetais terrestres. São por isso consideradas ingredientes funcionais, o que conduziu ao recente aumento do seu interesse comercial. A produção de microalgas c...

  3. Impacto do equilíbrio espinopélvico nos resultados clínicos e funcionais após artrodese instrumentada em doentes com espondilolistese degenerativa

    Directory of Open Access Journals (Sweden)

    Filipe Rodrigues Duarte

    2013-01-01

    Full Text Available OBJETIVO: Garantir o equilíbrio sagital e pélvico depois de correção cirúrgica de deformidade lombar tem sido alvo de atenção crescente na literatura. Estudos recentes demonstraram uma relação entre o equilíbrio espinopélvico e o resultado pós-operatório. Com a progressão da deformidade degenerativa, as alterações correspondentes dos parâmetros pélvicos são evidentes. Assim, os autores pretendem estudar a influência do equilíbrio espinopélvico nos resultados clínicos e funcionais após cirurgia de espondilolistese degenerativa (ED. MÉTODOS: Estudo retrospectivo. Amostra com 29 indivíduos com ED submetidos a descompressão e artrodese instrumentada entre 2006 e 2010. Média de idade 65,45 (± 8,15 anos. 20 mulheres e 9 homens. Acompanhamento médio - 2,1 anos. Avaliação clínica, funcional e radiológica. VAS, satisfação global, Oswestry Disability Index modificado. Cálculo de incidência pélvica, inclinação sacral, versão pélvica e lordose lombar. Dois grupos de estudo: A (n = 14: sem melhoria da versão pélvica (aumentada ou inalterada no pós-operatorio. B (n = 15: com melhoria da versão pélvica (diminuída. Estudo estatístico com SPSS®. RESULTADOS: A cirurgia é benéfica, reduz significativamente a dor e melhora a qualidade de vida. Os pacientes do grupo B (restituição do balanço original apresentam melhores resultados clínicos e funcionais (p < 0,05 e valores superiores de incidência pélvica relativamente ao grupo A. CONCLUSÃO: Este trabalho confirma a importância do equilíbrio espinopélvico como objetivo no planeamento cirúrgico e que a restituição do equilíbrio original parece obter melhores resultados.

  4. Brazilian legislation for functional foods and the interface with the legislation for other food and medicine classes: contradictions and omissions A legislação brasileira de alimentos funcionais e a interface com a legislação de outras classes de alimentos e medicamentos: um caso de contradições e omissões

    Directory of Open Access Journals (Sweden)

    Tatiana Feitoza Vianna da Silveira

    2009-01-01

    Full Text Available Functional foods are generally defined as foods that, due to their physiologically active substances, benefit health in addition to providing basic nourishment. As Brazilian legislation does not provide a definition for functional foods, the only possible actions is to claim that some foods have functional health proprieties. Based on a review of legislation, this paper discusses not only the lack of transparency in relation to the categories of products classified as foods and medicinal plants, but also the interactions and contradictions of functional food product legislation. Products may be classified either within the "New Food/or Ingredient category" or as "Bioactive Substances or Isolated Probiotics with Functional Properties and/ or Health Claims". Products such as garlic can also be classified into multiple food categories and as medicinal plants. Intersections in food legislation, especially with respect to functional and new food products, lead to misunderstandings and even omissions on the part of Brazilian National Sanitary Surveillance Agency (ANVISA. Moreover, health claims on food product labels can make distinction between foods and medicines difficult for consumers. In Brazil, clearer rules for the industry are necessary so that the consumer is not deceived by false cure promises.Alimentos funcionais são aqueles que, por seus componentes fisiologicamente ativos, beneficiam à saúde além da nutrição básica. A legislação Brasileira não contempla definição sobre Alimentos Funcionais, possibilitando apenas alegar que determinados alimentos possuem propriedades funcionais e/ou de saúde. Com base na revisão da legislação, apresenta-se uma discussão sobre sua ausência de clareza a respeito da categorização dos produtos que são registrados como alimentos e como medicamentos fitoterápicos; assim como interações e contradições da legislação de alimentos funcionais. Assim, um produto pode ser registrado tanto

  5. Regional variations in HDL metabolism in human fat cells: effect of cell size

    International Nuclear Information System (INIS)

    Despres, J.; Fong, B.S.; Julien, P.; Jimenez, J.; Angel, A.

    1987-01-01

    Abdominal obesity is related to reduced plasma high-density lipoprotein (HDL) cholesterol, and both are associated with cardiovascular disease risk. The authors have observed that plasma membranes from abdominal subcutaneous adipocytes have a greater HDL binding capacity than omental fat cell plasma membranes. The present study examined whether these binding characteristics could be due to differences in fat cell size or cholesterol concentration between the two adipose depots. Abdominal subcutaneous and deep omental fat were obtained from massively obese patients at surgery. Subcutaneous abdominal fat cells were significantly larger and their cellular cholesterol content greater than omental adipocytes. The uptake of HDL by collagenase-isolated fat cells was studied by incubating the cells for 2 h at 37 0 C with 10 μg/ml 125 I-HDL 2 or 125 I-HDL 3 . In both depots, the cellular uptake of 125 I-HDL 2 and 125 I-HDL 3 was specifically inhibited by addition of 25-fold excess unlabeled HDL and a close correlation was observed between the cellular uptake of 125 I-HDL 2 and 125 I-HDL 3 . In obese patients, the uptake of 125 I-HDL was higher in subcutaneous cells than in omental cells. The cellular 125 I-HDL uptake was significantly correlated with adipocyte size and fat cell cholesterol content but not with adipocyte cholesterol concentration. These results suggest that the higher HDL uptake observed in subcutaneous cells compared with omental cells in obesity is the result of differences in adipocyte size rather than differences in the cholesterol concentration (cholesterol-to-triglyceride ratio). The increased interaction of HDL with hypertrophied abdominal adipocytes may play an important role in determining the lipid composition of HDL in obesity

  6. HDL code analysis for ASICs in mobile systems

    OpenAIRE

    Wickberg, Fredrik

    2007-01-01

    The complex work of designing new ASICs today and the increasing costs of time to market (TTM) delays are putting high responsibility on the research and development teams to make fault free designs. The main purpose of implementing a static rule checking tool in the design flow today is to find errors and bugs in the hardware definition language (HDL) code as fast and soon as possible. The sooner you find a bug in the design, the shorter the turnaround time becomes, and thereby both time and...

  7. HDL proteome in hemodialysis patients: a quantitative nanoflow liquid chromatography-tandem mass spectrometry approach.

    Directory of Open Access Journals (Sweden)

    Alain Mangé

    Full Text Available Aside from a decrease in the high-density lipoprotein (HDL cholesterol levels, qualitative abnormalities of HDL can contribute to an increase in cardiovascular (CV risk in end-stage renal disease (ESRD patients undergoing chronic hemodialysis (HD. Dysfunctional HDL leads to an alteration of reverse cholesterol transport and the antioxidant and anti-inflammatory properties of HDL. In this study, a quantitative proteomics approach, based on iTRAQ labeling and nanoflow liquid chromatography mass spectrometry analysis, was used to generate detailed data on HDL-associated proteins. The HDL composition was compared between seven chronic HD patients and a pool of seven healthy controls. To confirm the proteomics results, specific biochemical assays were then performed in triplicate in the 14 samples as well as 46 sex-matched independent chronic HD patients and healthy volunteers. Of the 122 proteins identified in the HDL fraction, 40 were differentially expressed between the healthy volunteers and the HD patients. These proteins are involved in many HDL functions, including lipid metabolism, the acute inflammatory response, complement activation, the regulation of lipoprotein oxidation, and metal cation homeostasis. Among the identified proteins, apolipoprotein C-II and apolipoprotein C-III were significantly increased in the HDL fraction of HD patients whereas serotransferrin was decreased. In this study, we identified new markers of potential relevance to the pathways linked to HDL dysfunction in HD. Proteomic analysis of the HDL fraction provides an efficient method to identify new and uncharacterized candidate biomarkers of CV risk in HD patients.

  8. Survey of total error of precipitation and homogeneous HDL-cholesterol methods and simultaneous evaluation of lyophilized saccharose-containing candidate reference materials for HDL-cholesterol

    NARCIS (Netherlands)

    C.M. Cobbaert (Christa); H. Baadenhuijsen; L. Zwang (Louwerens); C.W. Weykamp; P.N. Demacker; P.G.H. Mulder (Paul)

    1999-01-01

    textabstractBACKGROUND: Standardization of HDL-cholesterol is needed for risk assessment. We assessed for the first time the accuracy of HDL-cholesterol testing in The Netherlands and evaluated 11 candidate reference materials (CRMs). METHODS: The total error (TE) of

  9. Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: “Herniated” HDL, a common feature in diabetes

    Science.gov (United States)

    Amigó, Núria; Mallol, Roger; Heras, Mercedes; Martínez-Hervás, Sergio; Blanco-Vaca, Francisco; Escolà-Gil, Joan Carles; Plana, Núria; Yanes, Óscar; Masana, Lluís; Correig, Xavier

    2016-01-01

    Recent studies have shown that pharmacological increases in HDL cholesterol concentrations do not necessarily translate into clinical benefits for patients, raising concerns about its predictive value for cardiovascular events. Here we hypothesize that the size-modulated lipid distribution within HDL particles is compromised in metabolic disorders that have abnormal HDL particle sizes, such as type 2 diabetes mellitus (DM2). By using NMR spectroscopy combined with a biochemical volumetric model we determined the size and spatial lipid distribution of HDL subclasses in a cohort of 26 controls and 29 DM2 patients before and after two drug treatments, one with niacin plus laropiprant and another with fenofibrate as an add-on to simvastatin. We further characterized the HDL surface properties using atomic force microscopy and fluorescent probes to show an abnormal lipid distribution within smaller HDL particles, a subclass particularly enriched in the DM2 patients. The reduction in the size, force cholesterol esters and triglycerides to emerge from the HDL core to the surface, making the outer surface of HDL more hydrophobic. Interestingly, pharmacological interventions had no effect on this undesired configuration, which may explain the lack of clinical benefits in DM2 subjects. PMID:26778677

  10. PADRÕES FUNCIONAIS DE SAÚDE: DIAGNÓSTICOS DE ENFERMAGEM EM ESCOLARES DA REDE PÚBLICA

    Directory of Open Access Journals (Sweden)

    Camila Dannyelle Fernandes Dutra Pereira

    2013-01-01

    Full Text Available El estudio identificó en los escolares de una escuela pública de Natal-RN alteraciones en los patrones de papel/relación, respuesta de tolerancia al estrés y creencia/valor, y determinó la frecuencia de las etiquetas diagnósticas de enfermería que se encuentra en estos tres patrones. Estudio descriptivo, transversal y cuantitativo, con estudiantes de quinto al noveno año, constituyendo una muestra de 276, que tuvo lugar entre febrero y marzo de 2011. Un instrumento basado en los Patrones Funcionales de Salud se utilizó para recolectar los datos, que se analizaron mediante estadística descriptiva con la distribución de frecuencias absolutas/relativas, y discutió sobre la base de la literatura. Las etiquetas diagnósticas de enfermería más comunes fueron: procesos familiares disfuncionales; riesgo de la violencia dirigida a los demás; y riesgo de deterioro de la religiosidad. El vínculo entre la salud y la educación es esencial, permite a la enfermera que trabaja en el ámbito escolar promover la salud de los estudiantes, la identificación de problemas y la formulación de diagnósticos, para que realizar la asistencia adecuada.

  11. Impaired HDL function in obese adolescents: impact of lifestyle intervention and bariatric surgery.

    Science.gov (United States)

    Matsuo, Yae; Oberbach, Andreas; Till, Holger; Inge, Thomas H; Wabitsch, Martin; Moss, Anja; Jehmlich, Nico; Völker, Uwe; Müller, Ulrike; Siegfried, Wolfgang; Kanesawa, Norio; Kurabayashi, Masahiko; Schuler, Gerhard; Linke, Axel; Adams, Volker

    2013-12-01

    HDL regulates endothelial function via stimulation of nitric oxide production. It is documented that endothelial function is impaired in obese adolescents, and improved by lifestyle interventions (LI). HDL function in obese adolescents and the impact of LI or Roux-en-Y gastric bypass surgery (RYGB) was assessed. HDL was isolated from 14 adolescents with normal body mass index (HDLcontrol ), 10 obese (HDLobese ) before and after 6 month LI, and five severe obese adolescents before and one year after RYGB. HDL-mediated phosphorylation of endothelial nitric oxide synthase (eNOS)-Ser(1177) , eNOS-Thr(495) , and PKC-ßII was evaluated. In addition the HDL proteome was analyzed. HDLobese -mediated eNOS-Ser(1177) phosphorylation was reduced, whereas eNOS-Thr(495) phosphorylation increased significantly when compared to HDLcontrol . No impact of obesity was observed on PKC-ßII phosphorylation. LI and RYGB had no impact on HDL-mediated phosphorylation of eNOS and PKC-ßII. A principle component plot analysis of the HDL particle separated controls and severe obese, whereas the interventions did not trigger sufficient differences to the HDL proteome to permit distinction. These results demonstrated that HDL-function is impaired in obese adolescents, and that LI or RYGB did not correct this dysfunction. This might be an argument for developing earlier prevention strategies in obese adolescents to avoid HDL dysfunction. Copyright © 2013 The Obesity Society.

  12. Targeted next-generation sequencing to diagnose disorders of HDL cholesterol.

    Science.gov (United States)

    Sadananda, Singh N; Foo, Jia Nee; Toh, Meng Tiak; Cermakova, Lubomira; Trigueros-Motos, Laia; Chan, Teddy; Liany, Herty; Collins, Jennifer A; Gerami, Sima; Singaraja, Roshni R; Hayden, Michael R; Francis, Gordon A; Frohlich, Jiri; Khor, Chiea Chuen; Brunham, Liam R

    2015-10-01

    A low level of HDL cholesterol (HDL-C) is a common clinical scenario and an important marker for increased cardiovascular risk. Many patients with very low or very high HDL-C have a rare mutation in one of several genes, but identification of the molecular abnormality in patients with extreme HDL-C is rarely performed in clinical practice. We investigated the accuracy and diagnostic yield of a targeted next-generation sequencing (NGS) assay for extreme levels of HDL-C. We developed a targeted NGS panel to capture the exons, intron/exon boundaries, and untranslated regions of 26 genes with highly penetrant effects on plasma lipid levels. We sequenced 141 patients with extreme HDL-C levels and prioritized variants in accordance with medical genetics guidelines. We identified 35 pathogenic and probably pathogenic variants in HDL genes, including 21 novel variants, and performed functional validation on a subset of these. Overall, a molecular diagnosis was established in 35.9% of patients with low HDL-C and 5.2% with high HDL-C, and all prioritized variants identified by NGS were confirmed by Sanger sequencing. Our results suggest that a molecular diagnosis can be identified in a substantial proportion of patients with low HDL-C using targeted NGS. Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc.

  13. Low Levels of HDL in Fragile X Syndrome Patients.

    Science.gov (United States)

    Lisik, Małgorzata Z; Gutmajster, Ewa; Sieroń, Aleksander L

    2016-02-01

    Fragile X syndrome (FXS) is the most common form of familial mental retardation and one of the leading known causes of autism. The mutation responsible for FXS is a large expansion of the CGG repeats in the promoter region of the FMR1 gene resulting in the transcriptional silencing of the gene in the pathophysiology of Fragile X syndrome was hypothesized. 23 male patients affected by Fragile X syndrome (full mutation in the FMR1 gene) and 24 controls were included in the study. The serum levels of HDL-C were lower in FXS patients (p < 0.001). The serum levels triacylglycerols were higher in FXS patients (p = 0.007) Further study involving larger samples are necessary to confirm the results and define the health implications for abnormal lipid levels in FXS patients.

  14. Avaliação do programa de exercícios funcionais vocais de Stemple e Gerdeman em professores Assessing of a vocal functional exercise program the Stemple and Gerdeman apllied to teachers

    Directory of Open Access Journals (Sweden)

    Rosangela Alves de Mendonça

    2010-06-01

    Full Text Available OBJETIVO: avaliar o efeito do Programa de Exercícios Funcionais Vocais de Stemple e Gerdeman em professoras, com e sem alteração vocal, que atuam no ensino fundamental do Município de Niterói-RJ. MÉTODOS: os sujeitos do estudo consistiram de 17 professoras, que aceitaram participar espontaneamente, de um grupo de 222 convidadas. Aplicou-se o programa de exercícios: vogal /i/ sustentada, glissando ascendente e descendente da palavra /nol/, e escala de tons musicais Dó, Ré, Mi, Fá, Sol, com emissão de /ol/, pelo tempo máximo de fonação. O programa de exercícios foi avaliado por meio da coleta dos dados: exame de vídeoendoscopia laríngea; avaliação perceptivo-auditiva da qualidade vocal (escala RASAT e variabilidade da fre quência fundamental, ambos por meio da fala espontânea; análise acústica (intensidade - diagrama de desvio fonatório e espectrograma pelo Programa de software Vox Metria, pré e pós-aplicação do programa, utilizando-se a vogal sustentada [ε]. RESULTADOS: houve aumento de tempo de fonação, da intensidade e da quantidade de harmônicos, além de ampliar a extensão da voz e melhorar a qualidade, resistência e projeção vocal. CONCLUSÃO: o Programa de Exercícios Funcionais Vocais de Stemple e Gerdeman possibilitou maior habilidade das participantes no desempenho profissional, benefícios que se estendem ao social.PURPOSE: the present research aims at assessing the effects of a Vocal Functional Exercise Program the Stemple and Gerdeman applied to teachers of the Elementary School Education level in the municipality of Niteroi/Brazil, with or without voice alterations. METHODS: the set of subjects consists of 17 female teachers who spontaneously agreed to participate from the initial group of 222 invited teachers. This is the exercise program that was applied: sustained vowel /i/, ascending and descending gliding on the word /nol/, and musical scale tones Do Re Mi Fa Sol - issuing the /ol/ for a

  15. Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population

    DEFF Research Database (Denmark)

    Frikke-Schmidt, Ruth; Nordestgaard, Børge G; Jensen, Gorm B

    2004-01-01

    or single-nucleotide polymorphisms (SNPs) in ABCA1 were overrepresented in individuals with the lowest 1% (n=95) or highest 1% (n=95) HDL-C levels in the general population by screening the core promoter and coding region of ABCA1. For all nonsynonymous SNPs identified, we determined the effect of genotype......Homozygosity for mutations in ABC transporter A1 (ABCA1) causes Tangier disease, a rare HDL-deficiency syndrome. Whether heterozygosity for genetic variation in ABCA1 also contributes to HDL cholesterol (HDL-C) levels in the general population is presently unclear. We determined whether mutations...... on lipid traits in 9,259 individuals from the general population. Heterozygosity for ABCA1 mutations was identified in 10% of individuals with low HDL-C only. Three of 6 nonsynonymous SNPs (V771M, V825I, and R1587K) were associated with increases or decreases in HDL-C in women in the general population...

  16. Phytoplankton composition and functional groups in a tropical humic coastal lagoon, Brazil Composição e grupos funcionais do fitoplâncton de uma lagoa costeira tropical húmica, Brasil

    Directory of Open Access Journals (Sweden)

    Catharina Alves-de-Souza

    2006-09-01

    Full Text Available This paper presents the composition and functional groups of the phytoplankton from Comprida lagoon, a tropical humic coastal Lagoon located in Southeast Brazil. A total of 28 taxa was found, distributed in eight taxonomic divisions as follows: 26% Heterokontophyta, 21% Chlorophyta, 21% Cyanophyta, 14% Bacillariophyta, 14% Cryptophyta, and 4% Prymnesiophyta. Twenty-three taxa were identified at the specific and infraspecific levels, from which four are new records for Brazil and two for Rio de Janeiro State. Phytoplankton of the Comprida lagoon was comprised of several flagellates, but also eukaryote and prokaryote picoplankton, filamentous cyanobacteria and several diatoms. The biomass was lower than that found in other lacustrine systems, and showed remarkable temporal variability. According to the functional-group approach, the populations formed eight groups: Q, Z, E, N, X3, X2, S1 and Y, most typical of oligo- or mesotrophic systems, tolerant to nutrient deficiency and sensitive to increased pH.Este trabalho apresenta a composição e os grupos funcionais do fitoplâncton da lagoa Comprida, uma lagoa costeira tropical húmica localizada no sudeste brasileiro. Foi registrado um total de 28 táxons distribuídos em oito divisões taxonômicas: 26% Heterokontophyta, 21% Chlorophyta, 21% Cyanophyta, 14% Bacillariophyta, 14% Cryptophyta e 4% Prymnesiophyta. Vinte e três táxons foram identificados em nível específico e intraespecíficos, dos quais quatro constituem novos registros para o Brasil e dois para o estado do Rio de Janeiro. O fitoplâncton da lagoa Comprida esteve constituído por alguns flagelados, mas também por organismos picoplanctônicos eucariontes e procariontes, cianobactérias filamentosas e algumas diatomáceas. A biomassa foi menor que a comumente encontrada em outros sistemas lacustres e mostrou uma notável variabilidade temporal. Em relação aos grupos funcionais, as populações foram agrupadas em oito grupos: Q, Z

  17. Radioterapia: lesões inflamatórias e funcionais de órgãos pélvicos Radiotherapy: inflammatory and functional lesions of pelvic organs

    Directory of Open Access Journals (Sweden)

    Júlio César Monteiro dos Santos Jr.

    2006-09-01

    Full Text Available A radioterapia pélvica tem sido cada vez mais indicada, em doses crescentes,como coadjuvante no tratamento das neoplasias pélvicas, com resultados cada vez melhores, mas com efeitos colaterais significativos. O advento da radioterapia tridimensional conformal estabelece um método que permite a mais precisa seleção de direção e de intensidade de raios emitidos para alvos pontuais, objetivando quase que exclusivamente o tumor, com a conseqüente preservação dos tecidos vizinhos, portanto com maior efetividade e com o mínimo de efeitos colaterais crônicos e insolúveis. Essas são as possibilidades teóricas que precisam ser comprovadas na prática.Elas envolvem um campo de observação cujos resultados reais tem sido subestimados, principalmente quando referidos a efeitos adversos. Esses não se limitam exclusivamente às mucosites, mas, também, a aspectos funcionais envolvendo incapacidades que vão, quando se trata do reto, além do que sempre foi atribuído à suposta síndrome da ressecção anterior 58, para abranger danos diretos da radiação sobre os complexos esfincterianos e os nervos dos plexos lombo-sacrais 21,22,59-63. Por enquanto, seja para o câncer de reto, para o câncer ginecológico e para o câncer de próstata, somos conclamados a investir no modelo mais preventivo do que curativo, ainda que o preventivo signifique apenas a mais precoce ação, pois para essas doenças de altas incidências e mortalidades "prevenir" no sentido de ação mais precoce é, sem dúvida, bem melhor que remediar, principalmente quando se faz uso das terapias neo-adjuvantes que poderiam ser dispensadas, em casos selecionados, para não somar ao desconforto emocional do portador do câncer todas as impossibilidades das iatrogenias inerentes ao tratamento que objetiva a cura. Assim, precisamos encontrar os fatores preditivos que nos permitam escolher os pacientes com probabilidade de cura apenas com o tratamento cirúrgico, para que eles

  18. Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III.

    Science.gov (United States)

    Koch, Manja; Furtado, Jeremy D; Jiang, Gordon Z; Gray, Brianna E; Cai, Tianxi; Sacks, Frank; Tjønneland, Anne; Overvad, Kim; Jensen, Majken K

    2017-06-01

    The presence of apoC-III on HDL impairs HDL's inverse association with coronary heart disease (CHD). Little is known about modifiable factors explaining variation in HDL subspecies defined according to apoC-III. The aim was to investigate cross-sectional associations of anthropometry and lifestyle with HDL subspecies in 3,631 participants from the Diet, Cancer, and Health study originally selected for a case-cohort study (36% women; age 50-65 years) who were all free of CHD. Greater adiposity and less activity were associated with higher HDL containing apoC-III and lower HDL lacking apoC-III. Per each 15 cm higher waist circumference, the level of HDL containing apoC-III was 2.8% higher (95% CI: 0.4, 5.3; P = 0.024) and the level of HDL not containing apoC-III was 4.7% lower (95% CI: -6.0, -3.4; P = <0.0001). Associations for physical activity were most robust to multivariable modeling. Each 20 metabolic equivalent task hours per week reported higher physical activity was associated with 0.9% (95% CI: -1.7, -0.1; P = 0.031) lower HDL containing apoC-III and 0.5% higher (95% CI: 0.1, 1.0; P = 0.029) HDL lacking apoC-III. Lower alcohol consumption was associated with lower HDL lacking apoC-III (percent difference per 15 g/day: 1.58 (95% CI: 0.84, 2.32; P = <0.0001). Adiposity and sedentary lifestyle were associated with a less favorable HDL subspecies profile. Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

  19. Estudos funcionais e moleculares relativos às membranas apicais intestinais de Dysdercus peruvianus

    OpenAIRE

    André Coppe Pimentel

    2016-01-01

    Os insetos da ordem Hemiptera apresentam membranas lipoproteicas que revestem as microvilosidades das células intestinais, como se fossem dedos de luva, e formam expansões para o lúmen do intestino que parecem terminar em fundo cego. A presença das duas membranas no ápice dos enterócitos gera questões intrigantes de como se dá a formação da membrana perimicrovilar, como ocorre a absorção de nutrientes e como se dá o encaminhamento de enzimas digestivas para o lúmen intestinal. A digestão de p...

  20. Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

    DEFF Research Database (Denmark)

    Elsøe, Sara; Ahnström, Josefin; Christoffersen, Christina

    2012-01-01

    Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lip...... a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL....

  1. Advances in the Study of the Antiatherogenic Function and Novel Therapies for HDL

    Directory of Open Access Journals (Sweden)

    Peiqiu Cao

    2015-07-01

    Full Text Available The hypothesis that raising high-density lipoprotein cholesterol (HDL-C levels could improve the risk for cardiovascular disease (CVD is facing challenges. There is multitudinous clear clinical evidence that the latest failures of HDL-C-raising drugs show no clear association with risks for CVD. At the genetic level, recent research indicates that steady-state HDL-C concentrations may provide limited information regarding the potential antiatherogenic functions of HDL. It is evident that the newer strategies may replace therapeutic approaches to simply raise plasma HDL-C levels. There is an urgent need to identify an efficient biomarker that accurately predicts the increased risk of atherosclerosis (AS in patients and that may be used for exploring newer therapeutic targets. Studies from recent decades show that the composition, structure and function of circulating HDL are closely associated with high cardiovascular risk. A vast amount of data demonstrates that the most important mechanism through which HDL antagonizes AS involves the reverse cholesterol transport (RCT process. Clinical trials of drugs that specifically target HDL have so far proven disappointing, so it is necessary to carry out review on the HDL therapeutics.

  2. Caracterização das habilidades funcionais na síndrome de Rett Characterization of functional abilities in Rett syndrome

    Directory of Open Access Journals (Sweden)

    Carlos Bandeira de Mello Monteiro

    2009-12-01

    Full Text Available O objetivo deste estudo foi identificar as áreas de maior comprometimento nas habilidades funcionais na síndrome de Rett (SR. Foram avaliadas 64 pacientes que preenchiam os critérios para a forma clássica da doença, com idade entre 2 e 26 anos. Foi aplicado o Inventário de avaliação pediátrica de incapacidade (PEDI que contém 197 itens nas áreas de autocuidado, mobilidade e função social. Dentre as 73 atividades da área de autocuidado, 52 (71,2% não foram realizadas por qualquer paciente; na mobilidade, dentre as 59 atividades propostas, 8 (13,5%; e na área de função social, dentre as 65 atividades, 50 (76,9% não foram realizadas por paciente alguma. O desempenho médio ajustado em escala de 0 a 100 para a área de autocuidado foi de 8,9/100, variando de 0 a 19; na área de mobilidade, foi de 30,2/100, variando de 1 a 44; e na de função social, 5,2/100, com variação de 0 a 14. Foi possível verificar fortes correlações entre a área de autocuidado e as de mobilidade e função social; no entanto, entre as áreas de mobilidade e função social não foi detectada correlação significativa. Infelizmente, devido à gravidade da síndrome, o menor comprometimento da mobilidade, comparado ao das áreas de autocuidado e função social, não traz vantagens adaptativas ou maior independência às pacientes com SR.The purpose of this study was to determine the areas of greater impairment in functional abilities of patients with Rett syndrome. Sixty-four patients aged 2 to 26 years old, who filled out criteria for the classic form of the disease, were assessed by the Pediatric Evaluation of Disability Inventory (PEDI of which 197 items are grouped in the areas of self-care, mobility, and social function. From the 73 activities in self-care area, 52 (71.2% were not accomplished by any patient; in mobility area, among the 59 proposed activities, 8 (13.5%; and in social function area, from 65 activities, 50 (76.9% could not be

  3. Rheological and sensory characteristics of functional dairy beverages / Características reológicas e sensoriais de bebidas lácteas funcionais

    Directory of Open Access Journals (Sweden)

    Ana Lúcia Barretto Penna

    2009-10-01

    Full Text Available This research studied the effects of the independent variables whey protein concentrate – WPC (3.0; 3.5; 4.0%, skimmed milk powder – SMP (4.0; 5.0; 6.0%, and isolated soy protein – IPS (1.5; 2.0; 2.5% on the rheological and sensorial characteristics of functional dairy beverages. In all tests 7% of sucrose was added to the ingredients. The rheological parameters were obtained in duplicate at the temperature of 10º C using a cone and plate rheometer, and fitted to the Power law model. The samples revealed a non-Newtonian fluid behavior both in the upward and downward curves, typical of a tixotropic fluid. The dairy beverages were submitted to a sensory analysis by a group of fifty untrained tasters who used a hedonic scale of nine points, the extremes being 1 – disliked extremely and 9 – liked extremely, in order to evaluate the following parameters: general acceptability; appearance and color; consistency; taste and aroma. The dairy beverage produced with 3% WPC, 6% SMP and 1.5% IPS, (treatment 3, was the one that obtained the best average score for those attributes and was preferred by the tasters. The variables SMP and IPS and the interaction between WPC and SMP presented a positive effect on the sensory consistency attributes: the higher amount of those ingredients in the formula the more the tasters liked the consistency.Neste trabalho foram estudados os efeitos das variáveis independentes: teor de soro de leite em pó (3,0; 3,5; 4,0%, teor de leite em pó desnatado (4,0; 5,0; 6,0% e teor de isolado proteico de soja (1,5; 2,0; 2,5% nas características reológicas e sensoriais de bebidas lácteas funcionais. Em todos os testes adicionou-se 7% de sacarose aos ingredientes. Os parâmetros reológicos foram determinados em duplicata na temperatura de 10ºC usando-se um reômetro de cone e placa, e ajustados pelo modelo da Lei da Potência. As amostras apresentaram comportamento de fluido não Newtoniano, nas curvas ascendentes e

  4. Atherogenic Impact of Lecithin-Cholesterol Acyltransferase and Its Relation to Cholesterol Esterification Rate in HDL (FERHDL) and AIP [log(TG/HDL-C)] Biomarkers: The Butterfly Effect?

    Czech Academy of Sciences Publication Activity Database

    Dobiášová, Milada

    2017-01-01

    Roč. 66, č. 2 (2017), s. 193-203 ISSN 0862-8408 Institutional support: RVO:67985823 Keywords : lecithin-cholesterol acyltransferase (LCAT) * atherosclerosis * FERHDL (fractional esterification rate in HDL) * AIP (atherogenic index of plasma, log(TG/HDL-C) * biomarkers of cardiometabolic risk * lipoprotein particle size Subject RIV: FA - Cardiovascular Disease s incl. Cardiotharic Surgery OBOR OECD: Endocrinology and metabolism (including diabetes, hormones) Impact factor: 1.461, year: 2016

  5. Biotechnological production of bioflavors and functional sugars Produção biotecnológica de bioaromas e açúcares funcionais

    Directory of Open Access Journals (Sweden)

    Juliano Lemos Bicas

    2010-03-01

    Full Text Available Bioflavors and oligosaccharides are two classes of substances that may be produced biotechnologically through microbial bioprocesses. These compounds have attracted the interest of pharmaceutical and food industries not only due to their technological properties (sweetening/fiber or flavoring, respectively, but also as a consequence of other functional properties such as, for example, health promoting benefits. The use of agro-industrial residues as substrates in biotechnological processes seems to be a valuable alternative in helping to overcome the high manufacturing costs of industrial fermentations. This manuscript reviews the most important advances in biotechnological production of bioflavors and oligosaccharides. The use of some agro-industrial residues in such processes is also cited and discussed, showing that this is a rising trend in biotechnology.Bioaromas e oligossacarídeos são duas classes de substâncias que podem ser produzidas biotecnológicamente por meio de bioprocessos microbiológicos. Estes compostos têm atraído o interesse das indústrias farmacêutica e de alimentos não só devido às suas propriedades tecnológicas (adoçantes/fibras ou aromatizantes, respectivamente, mas também como consequência de outras propriedades funcionais como, por exemplo, benefícios na promoção da saúde. O uso de resíduos agroindustriais como substrato em processos biotecnológicos parece ser uma alternativa valiosa para superar os altos custos de manufatura envolvidos nas fermentações industriais. Este manuscrito faz uma revisão dos mais importantes avanços na produção biotecnológica de bioaromas e oligossacarídeos. O uso de alguns resíduos agroindustriais nestes processos também são citados e discutidos, mostrando que esta é uma tendência crescente na biotecnologia.

  6. Treinamento físico para indivíduos HIV positivo submetidos à HAART: efeitos sobre parâmetros antropométricos e funcionais

    Directory of Open Access Journals (Sweden)

    Edmar Lacerda Mendes

    2013-02-01

    Full Text Available INTRODUÇÃO: A terapia antirretroviral fortemente ativa (HAART tem melhorado a prognose em indivíduos infectados pelo HIV. No entanto, a HAART tem sido associada ao desenvolvimento de anormalidades metabólicas e na distribuição de gordura corporal conhecida como síndrome lipodistrófica associada ao HIV (SLHIV. OBJETIVO: Este estudo investigou o impacto de 24 semanas de exercício resistido com componente aeróbico (ERCA sobre parâmetros antropométricos e funcionais de portadores de HIV submetidos à HAART. MÉTODOS: Noventa e nove indivíduos infectados pelo HIV foram randomicamente alocados em quatro grupos: exercício e lipodistrofia (n = 24; EX+LIP; exercício sem lipodistrofia (n = 21; EX+NoLIP; controle e lipodistrofia (n = 27; NoEX+LIP; controle sem lipodistrofia (n = 27; NoEX+NoLIP. Os indivíduos dos grupos exercitados (EX+LIP e EX+NoLIP participaram de 24 semanas de ERCA. Nos momentos pré e pós 24 semanas de intervenção foram realizadas medidas antropométricas, testes de força e aptidão cardiorrespiratória. RESULTADOS: Vinte e quatro semanas de ERCA alteraram os perímetros corporais avaliados (P < 0,0001 e a relação cintura/quadril (P = 0,017 nos dois grupos exercitados. Reduções foram observadas (P < 0,0001 para o somatório das sete dobras cutâneas avaliadas, percentual de gordura corporal, massa corporal gorda, gordura subcutânea total, central e periférica em resposta ao ERCA. A massa corporal magra aumentou (P < 0,0001 nos grupos exercitados, independente do desfecho (LIP ou NoLIP. A força muscular e a aptidão cardiorrespiratória aumentaram (P < 0,0001, para os dois grupos exercitados em resposta ao ERCA. CONCLUSÃO: Vinte e quatro semanas de ERCA impediram a manifestação das alterações decorrentes da SLHIV e contribuíram para a redução destas.

  7. High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study.

    Science.gov (United States)

    Arts, Elke; Fransen, Jaap; Lemmers, Heidi; Stalenhoef, Anton; Joosten, Leo; van Riel, Piet; Popa, Calin D

    2012-05-14

    Higher levels of high density lipoprotein (HDL) subfractions HDL3-chol and particularly HDL2-chol protect against cardiovascular disease (CVD), but inflammation reduces the HDL level and may impair its anti-atherogenic effect. Changed HDL composition through the impact of inflammation on HDL subfractions may contribute to the excess risk of CVD in rheumatoid arthritis (RA). In this study, we investigated whether HDL2-chol and HDL3-chol concentrations differ between RA patients and healthy controls, and whether these levels are related to the level of RA disease activity. Non-fasting blood samples were collected from 45 RA patients and 45 healthy controls. None of the participants had a history of CVD, diabetes, or used lipid-lowering drugs. HDL2-chol and HDL3-chol concentrations were obtained by ultracentrifugation. Regression modeling was used to compare HDL subfraction levels between RA patients and healthy controls, and to analyze the effect of disease activity on HDL2-chol and HDL3-chol. HDL2-chol and HDL3-chol were significantly lower in RA patients compared to healthy controls (P = 0.01, P = 0.005, respectively). The HDL2:HDL3 ratio was significantly lower in patients compared to controls (P = 0.04). Reduced HDL2-chol and HDL3-chol levels were primarily present in female RA patients and not in male RA patients. A modest effect of the disease activity score in 28 joins ( DAS28) on HDL2-chol concentrations was found, after correction for disease duration, glucocorticosteroid use and body mass index (BMI), with a 0.06 mmol/L decrease with every point increase in DAS28 (P = 0.05). DAS28 did not significantly affect HDL3-chol concentrations (P = 0.186). Both HDL subfractions but particularly HDL2-chol concentrations were decreased in RA, primarily in women. This seems to be associated with disease activity and is of clinical relevance. The reduction of the HDL subfraction concentrations, particularly the supposedly beneficial HDL2-chol, may negatively impact the

  8. Prevalence of low HDL cholesterol, and relationship between serum HDL and cardiovascular disease in elderly Spanish population: the PREV-ICTUS study.

    Science.gov (United States)

    Cea-Calvo, L; Lozano, J V; Fernández-Pérez, C; Llisterri, J L; Martí-Canales, J C; Aznar, J; Gil-Guillén, V; Redón, J

    2009-01-01

    To assess the prevalence of low serum high-density lipoprotein cholesterol (HDL-C) concentration and the relationship between HDL-C and established cardiovascular disease (CVD) in an elderly Mediterranean population. Analysis of Prevención del Riesgo de Ictus, a population-based study on Spanish subjects aged > or = 60 years. Low HDL-C was defined following the European guidelines for cardiovascular prevention [men: 65 mg/dl (> 1.67 mmol/l)], adjusted OR for CVD were 1.39 (1.10-1.76), 1.41 (1.11-1.80), 1.49 (1.18-1.89) and 1.91 (1.52-2.39), respectively for those in the fourth [57-65 mg/dl (1.46-1.67 mmol/l)], third [51-56 mg/dl (1.31-1.45 mmol/l)], second [46-50 mg/dl (1.18-1.30 mmol/l)] and first [ or = 60 years had low HDL-C. We found a strong, independent and inverse association between HDL-C concentrations and established CVD, even at ranges of HDL-C considered as normal.

  9. Sarcopenia no envelhecimento: alterações funcionais, estruturais e bioquímicas

    OpenAIRE

    Zhong, S; Chen, CN; Thompson, LV

    2007-01-01

    Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular and biochemical changes that contribute to age-related muscle weakness.O envelhecimento está associado ao declínio progressivo da massa, força, e q...

  10. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

    DEFF Research Database (Denmark)

    Postmus, Iris; Warren, Helen R; Trompet, Stella

    2016-01-01

    BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation. METHODS AND RESULTS: We perform...

  11. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

    DEFF Research Database (Denmark)

    Christoffersen, Christina; Obinata, Hideru; Kumaraswamy, Sunil B

    2011-01-01

    Protection of the endothelium is provided by circulating sphingosine-1-phosphate (S1P), which maintains vascular integrity. We show that HDL-associated S1P is bound specifically to both human and murine apolipoprotein M (apoM). Thus, isolated human ApoM(+) HDL contained S1P, whereas ApoM(-) HDL did...... not. Moreover, HDL in Apom(-/-) mice contains no S1P, whereas HDL in transgenic mice overexpressing human apoM has an increased S1P content. The 1.7-Å structure of the S1P-human apoM complex reveals that S1P interacts specifically with an amphiphilic pocket in the lipocalin fold of apoM. Human ApoM......(+) HDL induced S1P(1) receptor internalization, downstream MAPK and Akt activation, endothelial cell migration, and formation of endothelial adherens junctions, whereas apoM(-) HDL did not. Importantly, lack of S1P in the HDL fraction of Apom(-/-) mice decreased basal endothelial barrier function in lung...

  12. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

    NARCIS (Netherlands)

    D. Postmus (Douwe); H. Warren (Helen); S. Trompet (Stella); B.J. Arsenault (Benoit J.); C.L. Avery; J.C. Bis (Joshua); D.I. Chasman (Daniel); C.E. de Keyser (Catherina Elisabeth); H. Deshmukh (Harshal); D.S. Evans (Daniel); Feng, Q. (QiPing); X. Li (Xiaohui); Smit, R.A.J. (Roelof A.J.); A.V. Smith (Albert Vernon); F. Sun (Fangui); K.D. Taylor (Kent); A.M. Arnold (Alice M.); M.J. Barnes (Michael); B.J. Barratt (Bryan J.); J. Betteridge (John); S.M. Boekholdt (Matthijs); E.A. Boerwinkle (Eric); B.M. Buckley (Brendan M.); Y.D. Chen (Y.); A.J. de Craen (Anton); S. Cummings; Denny, J.C. (Joshua C.); G.P. Dubé (Gregory); P.N. Durrington (Paul); G. Eiriksdottir (Gudny); I. Ford (Ian); X. Guo (Xiuqing); T.B. Harris (Tamara); S.R. Heckbert (Susan); A. Hofman (Albert); G. Kees Hovingh; J.J.P. Kastelein (John); Launer, L.J. (Leonore J.); Liu, C.-T. (Ching-Ti); Y. Liu (YongMei); T. Lumley (Thomas); P.M. Mckeigue (Paul); P. Munroe (Patricia); A. Neil (Andrew); D.A. Nickerson (Deborah); F. Nyberg (Fredrik); E. O'Brien (Eoin); C.J. O'Donnell (Christopher); W.S. Post (Wendy S.); N.R. Poulter (Neil); R.S. Vasan (Ramachandran Srini); K.M. Rice (Kenneth); S.S. Rich (Stephen); F. Rivadeneira Ramirez (Fernando); N. Sattar (Naveed); P. Sever (Peter); S. Shaw-Hawkins (Sue); D.C. Shields (Denis C.); P.E. Slagboom (Eline); N.L. Smith (Nicholas); J.D. Smith (Joshua D.); N. Sotoodehnia (Nona); A. Stanton (Alice); D.J. Stott (David. J.); B.H.Ch. Stricker (Bruno); T. Stürmer; A.G. Uitterlinden (André); W.-Q. Wei (Wei-Qi); R.G.J. Westendorp (Rudi); E.A. Whitsel (Eric A.); K.L. Wiggins (Kerri); R.A. Wilke (Russell A.); C. Ballantyne (Christie); H.M. Colhoun (H.); L.A. Cupples (Adrienne); O.H. Franco (Oscar); V. Gudnason (Vilmundur); G.A. Hitman (Graham); C.N.A. Palmer (Colin); B.M. Psaty (Bruce); P.M. Ridker (Paul); J.M. Stafford (Jeanette M.); Stein, C.M. (Charles M.); J.-C. Tardif (Jean-Claude); M. Caulfield (Mark); J.W. Jukema (Jan Wouter); Rotter, J.I. (Jerome I.); R.M. Krauss (Ronald)

    2016-01-01

    textabstractBackground In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Interindividual variation in HDL-C response to statins may be partially explained by genetic variation. Methods and results We

  13. Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice.

    Directory of Open Access Journals (Sweden)

    Matteo Pedrelli

    Full Text Available OBJECTIVES: ACAT2 is the exclusive cholesterol-esterifying enzyme in hepatocytes and enterocytes. Hepatic ABCA1 transfers unesterified cholesterol (UC to apoAI, thus generating HDL. By changing the hepatic UC pool available for ABCA1, ACAT2 may affect HDL metabolism. The aim of this study was to reveal whether hepatic ACAT2 influences HDL metabolism. DESIGN: WT and LXRα/β double knockout (DOKO mice were fed a western-type diet for 8 weeks. Animals were i.p. injected with an antisense oligonucleotide targeted to hepatic ACAT2 (ASO6, or with an ASO control. Injections started 4 weeks after, or concomitantly with, the beginning of the diet. RESULTS: ASO6 reduced liver cholesteryl esters, while not inducing UC accumulation. ASO6 increased hepatic ABCA1 protein independently of the diet conditions. ASO6 affected HDL lipids (increased UC only in DOKO, while it increased apoE-containing HDL in both genotypes. In WT mice ASO6 led to the appearance of large HDL enriched in apoAI and apoE. CONCLUSIONS: The use of ASO6 revealed a new pathway by which the liver may contribute to HDL metabolism in mice. ACAT2 seems to be a hepatic player affecting the cholesterol fluxes fated to VLDL or to HDL, the latter via up-regulation of ABCA1.

  14. The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?

    NARCIS (Netherlands)

    Vergeer, Menno; Holleboom, Adriaan G.; Kastelein, John J. P.; Kuivenhoven, Jan Albert

    2010-01-01

    There is unequivocal evidence of an inverse association between plasma high-density lipoprotein (HDL) cholesterol concentrations and the risk of cardiovascular disease, a finding that has led to the hypothesis that HDL protects from atherosclerosis. This review details the experimental evidence for

  15. Abnormalities in lipoprotein metabolism: from dysfunctional HDL to abnormal processing of triglyceride rich lipoproteins

    NARCIS (Netherlands)

    Franssen, R.

    2010-01-01

    Remco Franssen bestudeerde de rol van HDL, van nature gezien als het goede cholesterol, in ontstekingsprocessen en in het reverse cholesterol transport. Het kunstmatige rHDL is in staat de gevolgen van een stijging van het ontstekingseiwit CRP te voorkomen. Een chronische ontsteking als reuma of de

  16. In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models

    DEFF Research Database (Denmark)

    Pérez-Medina, Carlos; Binderup, Tina; Lobatto, Mark E

    2016-01-01

    OBJECTIVES: The goal of this study was to develop and validate a noninvasive imaging tool to visualize the in vivo behavior of high-density lipoprotein (HDL) by using positron emission tomography (PET), with an emphasis on its plaque-targeting abilities. BACKGROUND: HDL is a natural nanoparticle......,2-distearoyl-sn-glycero-3-phosphoethanolamine-deferoxamine B). Biodistribution and plaque targeting of radiolabeled HDL were studied in established murine, rabbit, and porcine atherosclerosis models by using PET combined with computed tomography (PET/CT) imaging or PET combined with magnetic resonance imaging......-injection for both (89)Zr-HDL nanoparticles. In the porcine model, increased accumulation of radioactivity was observed in lesions by using in vivo PET imaging. Irrespective of the radiolabel's location, HDL nanoparticles were able to preferentially target plaque macrophages and monocytes. CONCLUSIONS: (89)Zr...

  17. Glycation of human high density lipoprotein by methylglyoxal: effect on HDL-paraoxonase activity.

    Science.gov (United States)

    Bacchetti, Tiziana; Masciangelo, Simona; Armeni, Tatiana; Bicchiega, Virginia; Ferretti, Gianna

    2014-03-01

    Methylglyoxal (MG), a reactive carbonyl compound formed primarily from triose phosphates, appears to be involved in the molecular mechanisms of diabetes, end-stage renal disease and neurodegenerative diseases. Methylglyoxal exerts several biological activities. Among these it promotes advanced glycation end products (AGEs), which are crucial in pathogenesis of human disease. Previous studies have demonstrated that MG reacts with proteins and compositional modifications reflect loss of biological activity. The aim of the study was to investigate the effect of in vitro MG-induced glycation on human high density lipoprotein (HDL) and on the activity of the enzyme paraoxonase-1 (PON1). HDL was incubated in the absence or in the presence of MG (0.2mmol/L and 1.0mmol/L) (MG-HDL) for different times (3, 6, 24h) at 37° C. We evaluated apoprotein compositional changes, in both control and MG treated HDL, using intrinsic fluorescence of tryptophan and monitoring the decrease of free amino groups. Furthermore we evaluated fluorescent advanced glycation end products (Ex=370nm, Em=440nm) and the activity of HDL-paraoxonase. We demonstrated that human HDL is susceptible to glycation by MG (0.2mmol/L and 1mmol/L). The decrease of free amino groups and of intrinsic fluorescence of tryptophan demonstrates HDL apoprotein modifications in HDL incubated with MG. The compositional changes are associated with a significant increase in fluorescent advanced glycation end products and with a significant decrease of paraoxonase-1 enzyme activity associated with the HDL surface. HDL-associated paraoxonase is responsible for the anti-inflammatory and anti-oxidative properties of HDL and detoxification against homocysteine-thiolactone. Therefore, modifications of apoprotein composition and the decrease of paraoxonase-1 activity in MG-treated HDL could affect the protective effect exerted by HDL against oxidative damage and could contribute to complications in patients affected by diseases

  18. Beneficial Effect of Higher Dietary Fiber Intake on Plasma HDL-C and TC/HDL-C Ratio among Chinese Rural-to-Urban Migrant Workers.

    Science.gov (United States)

    Zhou, Quan; Wu, Jiang; Tang, Jie; Wang, Jia-Ji; Lu, Chu-Hong; Wang, Pei-Xi

    2015-04-29

    Research has shown that high-dose supplemental dietary fiber intake has beneficial effects on cardiovascular risk factors. To clarify such a relationship, we examined the association between daily dietary fiber intake and plasma lipids using a cross-sectional design including 1034 (M 502, F 532) rural-to-urban workers in China. We found a dose-response relationship between increased dietary fiber intakes and increase of HDL cholesterol in male workers. There was also a dose-response relationship between increased dietary fiber intake and decreased total cholesterol to HDL cholesterol (TC/HDL-C) ratio in both male and female workers, after adjusting for potential confounders (p for trend, all p dietary fiber intake increased from less than 18 g/day to over 30 g/day, the average HDL cholesterol level increased by 10.1%, and the TC/HDL-C ratio decreased by 14.4% for males (p = 0.020) and by 11.1% for females (p = 0.048). In conclusion, higher daily dietary fiber consumption is associated with beneficial effect on cholesterol for rural-to-urban workers in China, suggesting its potential beneficial effect on decreasing the risk of cardiovascular diseases.

  19. HDL enhances oxidation of LDL in vitro in both men and women

    Directory of Open Access Journals (Sweden)

    Lehtimäki T

    2005-10-01

    Full Text Available Abstract Background Oxidative modification of low-density lipoprotein (LDL is a key event in the oxidation hypothesis of atherogenesis. Some in vitro experiments have previously suggested that high-density lipoprotein (HDL co-incubated with LDL prevents Cu2+-induced oxidation of LDL, while some other studies have observed an opposite effect. To comprehensively clarify the role of HDL in this context, we isolated LDL, HDL2 and HDL3 from sera of 61 free-living individuals (33 women and 28 men. Results When the isolated LDL was subjected to Cu2+-induced oxidation, both HDL2 and HDL3 particles increased the rate of appearance and the final concentration of conjugated dienes similarly in both genders. Oxidation rate was positively associated with polyunsaturated fatty acid content of the lipoproteins in that it was positively related to the content of linoleate and negatively related to oleate. More saturated fats thus protected the lipoproteins from damage. Conclusion We conclude that in vitro HDL does not protect LDL from oxidation, but is in fact oxidized fastest of all lipoproteins due to its fatty acid composition, which is oxidation promoting.

  20. [ANTIOXIDANT DYSFUNCTIONALITY OF HIGH-DENSITY LIPOPROTEINS (HDL) IN DECOMPENSATED DIABETIC PATIENTS].

    Science.gov (United States)

    Awad, Fernanda; Contreras-Duarte, Susana; Molina, Patricia; Quiñones, Verónica; Serrano, Valentina; Abbott, Eduardo; Maiz, Alberto; Busso, Dolores; Rigotti, Attilio

    2015-09-01

    high density lipoproteins (HDL) have important cardiovascular protective effects mediated by their role in reverse cholesterol transport as well as other functional activities, including significant anti-inflammatory and antioxidant properties. It has been shown that HDL anti-inflammatory and antioxidant functions are defective in metabolically stable diabetic patients; however they have not been evaluated during a hyperglycemic crisis. to determine the antioxidant activity of HDL during a severe diabetic decompensation and to analyze whether this function is restored after resolution of the acute event. the antioxidant activity of HDL was measured in vitro by a fluorescent assay in plasma samples obtained from diabetic patients with acute metabolic decompensation at admission, recovery within the hospital and follow-up in ambulatory care. As a comparison, HDL particles from some healthy subjects were used as controls. the HDL antioxidant function was significantly reduced in patients during an acute diabetic decompensation compared with the control group, and was gradually restored reaching normal values during the ambulatory follow-up. Hyperglycemic crisis also showed low plasma paraoxonase-1 activity, which increased significantly during at follow-up. HDL particles isolated from acute diabetic descompensated patients exhibit a significantly and reversibly low antioxidant capacity, which is probably due to a reduced paraoxonase-1 activity. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  1. Discordance between high non-HDL cholesterol and high LDL-cholesterol among US adults.

    Science.gov (United States)

    Kilgore, Meredith; Muntner, Paul; Woolley, J Michael; Sharma, Pradeep; Bittner, Vera; Rosenson, Robert S

    2014-01-01

    Although low-density lipoprotein cholesterol (LDL-C) is recommended as the primary marker to guide lipid-lowering therapy, some data suggest non-high-density lipoprotein cholesterol (non-HDL-C) may better reflect coronary heart disease risk. Discordance between these measures has not been evaluated. We used data from the National Health and Nutrition Examination Surveys 2005-2010 (n = 4986) to examine the discordance between these lipid parameters. Elevated levels of non-HDL-C and LDL-C were defined by using the 2004 Adult Treatment Panel III guidelines. The prevalence of high non-HDL-C and LDL-C was 22.7% and 24.5%, respectively. Of participants with high non-HDL-C, 9.7% had normal LDL-C, whereas 15.7% of participants with high LDL-C had normal non-HDL-C. We estimate 3.9 million US adults had high non-HDL-C and normal LDL-C, whereas 6.8 million US adults had high LDL-C and normal non-HDL-C. Persons with high non-HDL-C and normal LDL-C were older, more likely to be men, Hispanic, and have impaired fasting glucose, diabetes metabolic syndrome, and more risk factors for coronary heart disease. Substantial discordance exists between high non-HDL-C and high LDL-C among US adults. Reliance on either single measure could result in failure to classify cardiovascular heart disease risks appropriately. Copyright © 2014 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  2. Identification of cardiometabolic risk: visceral adiposity index versus triglyceride/HDL cholesterol ratio.

    Science.gov (United States)

    Salazar, Martin R; Carbajal, Horacio A; Espeche, Walter G; Aizpurúa, Marcelo; Maciel, Pablo M; Reaven, Gerald M

    2014-02-01

    The plasma concentration ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) can identify cardiometabolic risk and cardiovascular disease. The visceral adiposity index is a sex-specific index, in which measurements of body mass index and waist circumference are combined with TG and HDL-C concentrations. The current analysis was initiated to see if the visceral adiposity index would improve the ability of the TG/HDL-C to identify increased cardiometabolic risk and outcome. Cardiometabolic data were obtained in 2003 from 926 apparently healthy individuals, 796 of whom were evaluated in 2012 for evidence of incident cardiovascular disease. The relationship between TG/HDL-C and values for visceral adiposity index was evaluated by Pearson's correlation coefficient. The relative risks for first cardiovascular event between individuals above and below the TG/HDL-C sex-specific cut points, and in the top quartile of visceral adiposity index versus the remaining 3 quartiles, were estimated using Cox proportional hazard models. TG/HDL-C concentration and visceral adiposity index were highly correlated (r = 0.99) in both men and women. Although more men (133 vs121) and women (73 vs 59) were identified as being at "high risk" by an elevated TG/HDL-C ratio, the individual cardiometabolic risk factors were essentially identical with either index used. However, the hazard ratio of developing cardiovascular disease was significantly increased in individuals with an elevated TG/HDL-C, whereas it was not the case when the visceral adiposity index was used to define "high risk." The visceral adiposity index does not identify individuals with an adverse cardiometabolic profile any better than the TG/HDL-C. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. O projeto da habitação de interesse social e a sustentabilidade social

    OpenAIRE

    Reis,Antônio Tarcísio da Luz; Lay,Maria Cristina Dias

    2010-01-01

    O objetivo deste artigo é reforçar a importância da sustentabilidade social para o projeto da habitação de interesse social e apontar recomendações projetuais que possuam o potencial de qualificar a habitação de interesse social, com base em investigações realizadas. A qualidade das soluções arquitetônicas envolvendo os aspectos estéticos e funcionais do projeto da habitação social determina a eficiência com que o projeto responde às necessidades de seus usuários. Projetos habitacionais para ...

  4. Coenzyme O*U1*UO, Alpha-Tocopherol and Free Cholesterol in HDL and LDL Fractions

    DEFF Research Database (Denmark)

    Johansen, Kurt; Theorell, Henning; Karlsson, Jan

    1991-01-01

    Farmakologi, Alpha-tocopherol, Coenzyme Q*U1*U0, free cholesterol, LDL, Antioxidants, Lipoproteins, HDL......Farmakologi, Alpha-tocopherol, Coenzyme Q*U1*U0, free cholesterol, LDL, Antioxidants, Lipoproteins, HDL...

  5. Propriedades fisiológicas-funcionais das proteínas do soro de leite Physiological-functional properties of milk whey proteins

    Directory of Open Access Journals (Sweden)

    Valdemiro Carlos Sgarbieri

    2004-12-01

    Full Text Available O presente artigo coloca em destaque as propriedades multifuncionais das proteínas presentes no soro de leite bovino, a começar pelo colostro que contém essas proteínas em concentrações muito elevadas e que tem por função garantir a proteção e a imunidade dos recém-nascidos. Essas mesmas proteínas continuam no leite, porém em concentrações bastante reduzidas. A utilização dessas proteínas nas formas de concentrados e isolados protéicos evidenciam propriedades muito favoráveis à saúde no sentido de diminuir o risco de doenças infecciosas e também as consideradas crônicas e/ou degenerativas. Enfatizou-se as propriedades das proteínas do soro de leite e de peptídios delas resultantes no estímulo ao sistema imunológico, na proteção contra microrganismos patogênicos e contra alguns tipos de vírus como o HIV e o vírus da hepatite C, na proteção contra vários tipos de câncer, particularmente de cólon, na proteção da mucosa gástrica contra agressão por agentes ulcerogênicos, evidenciou-se várias linhas de ação protetora das proteínas de soro contra agentes condicionadores de problemas cardiovasculares. Com base em várias propriedades funcionais das proteínas do soro de leite, discutiu-se a vantagem e os benefícios de seu uso como suplemento alimentar para atletas e esportistas em geral. Os possíveis benefícios de vários fatores de crescimento celular, presentes no soro de leite também foram discutidos.This article emphasizes the multifunctional properties of the bovine milk whey proteins, starting with the colostrum where these proteins occur in high concentrations and are reputed as responsible for the protection and passive immunization of the newborn babies. The same proteins found in colostrum in high concentrations are found in milk although at much lower concentrations. The utilization of the milk whey proteins in the form of concentrates or isolates has been found to be highly beneficial to

  6. PLTP activity in premenopausal women. Relationship with lipoprotein lipase, HDL, LDL, body fat, and insulin resistance.

    Science.gov (United States)

    Murdoch, S J; Carr, M C; Hokanson, J E; Brunzell, J D; Albers, J J

    2000-02-01

    Plasma phospholipid transfer protein (PLTP) is thought to play a major role in the facilitated transfer of phospholipids between lipoproteins and in the modulation of high density lipoprotein (HDL) particle size and composition. However, little has been reported concerning the relationships of PLTP with plasma lipoprotein parameters, lipolytic enzymes, body fat distribution, insulin, and glucose in normolipidemic individuals, particularly females. In the present study, 50 normolipidemic healthy premenopausal females were investigated. The relationships between the plasma PLTP activity and selected variables were assessed. PLTP activity was significantly and positively correlated with low density lipoprotein (LDL) cholesterol (r(s) = 0.53), apoB (r(s) = 0.44), glucose (r(s) = 0.40), HDL cholesterol (r(s) = 0.38), HDL(3) cholesterol (r(s) = 0.37), lipoprotein lipase activity (r(s) = 0.36), insulin (r(s) = 0.33), subcutaneous abdominal fat (r(s) = 0.36), intra-abdominal fat (r(s) = 0.29), and body mass index (r(s) = 0.29). HDL(2) cholesterol, triglyceride, and hepatic lipase were not significantly related to PLTP activity. As HDL(2) can be decreased by hepatic lipase and hepatic lipase is increased in obesity with increasing intra-abdominal fat, the participants were divided into sub-groups of non-obese (n = 35) and obese (n = 15) individuals and the correlation of PLTP with HDL(2) cholesterol was re-examined. In the non-obese subjects, HDL(2) cholesterol was found to be significantly and positively related to PLTP activity (r(s) = 0.44). Adjustment of the HDL(2) values for the effect of hepatic lipase activity resulted in a significant positive correlation between PLTP and HDL(2) (r(s) = 0.41), indicating that the strength of the relationship between PLTP activity and HDL(2) can be reduced by the opposing effect of hepatic lipase on HDL(2) concentrations. We conclude that PLTP-facilitated lipid transfer activity is related to HDL and LDL metabolism, as well as

  7. Relationship between force platform and two functional tests for measuring balance in the elderly Relação entre plataforma de força e dois testes funcionais para medidas de equilíbrio em idosos

    Directory of Open Access Journals (Sweden)

    André W. O. Gil

    2011-12-01

    e quatro idosos fisicamente independentes e voluntários participaram deste estudo. Os sujeitos realizaram três testes: 1 teste tradicional e funcional de equilíbrio estático, que mede o tempo-limite em segundos de apoio unipodal; 2 teste funcional de agilidade e equilíbrio dinâmico, que quantifica o tempo total em segundos para realizar uma tarefa de sentar, levantar e locomover-se o mais rápido possível em torno de dois cones e 3 teste de equilíbrio unipodal sobre uma plataforma de força. RESULTADOS: A média do tempo-limite para o teste funcional de equilíbrio estático foi de 12 segundos (DP=9s, enquanto a média de tempo para o teste funcional de agilidade e equilíbrio dinâmico foi de 26 segundos (DP=6s. As correlações entre os parâmetros de equilíbrio da plataforma de força e os testes funcionais variaram entre -0,28 e 0,20, sugerindo uma associação fraca entre eles. CONCLUSÕES: Os resultados suportam a ideia de que os dois testes funcionais não fornecem, necessariamente, a mesma informação que uma plataforma fornece quanto aos mecanismos de controle postural para equilíbrio. Este estudo colabora para a avaliação do equilíbrio em idosos e sugere que alguns testes funcionais deveriam ser usados com mais cautela quanto à sua indicação no alcance dos objetivos da pesquisa e na identificação dos possíveis déficits de equilíbrio, especialmente quando usados para avaliação clínica de idosos.

  8. Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels

    DEFF Research Database (Denmark)

    Haase, C L; Frikke-Schmidt, R; Nordestgaard, B G

    2011-01-01

    levels. Mutations in apolipoprotein (apo) A-I, the major protein constituent of HDL, might be associated with low HDL cholesterol and predispose to IHD and early death. DESIGN: We resequenced APOA1 in 190 individuals and examined the effect of mutations on HDL cholesterol, risk of IHD, myocardial...

  9. Performances comparées du HDL-cholestérol et du ratio cholestérol ...

    African Journals Online (AJOL)

    Current definition criteria of the metabolic syndrome (MetS) do not adequately identify at risk African origin subjects. The objective was to determine which of total cholesterol/HDL-cholesterol (TC/HDL-C) and HDL-cholesterol is the best predictor of metabolic syndrome (SMet) in Benin adults. This cross-sectional study was ...

  10. Mudanças funcionais de farinha de arroz torrada com micro-ondas em função do teor de umidade e do tempo de processamento Functional changes of rice flour roasted with microwave as a function of moisture content and processing time

    Directory of Open Access Journals (Sweden)

    July-Ana Souza Tavares

    2012-06-01

    Full Text Available O Brasil está entre os dez maiores produtores de arroz do mundo. Devido ao beneficiamento, boa parte dos grãos é quebrada, gerando um subproduto de baixo valor comercial. A farinha de arroz normalmente é produzida a partir de grãos quebrados e é utilizada em produtos manufaturados devido a suas propriedades funcionais. Visando à obtenção de farinhas com propriedades funcionais diferenciadas e assim ampliar sua utilização como ingrediente em diferentes aplicações na indústria de alimentos, o objetivo deste trabalho foi avaliar o efeito da umidade e do tempo de torra (variáveis independentes, em micro-ondas, sobre as características funcionais de farinhas de arroz da cultivar 'IRGA 417'. Utilizou-se delineamento experimental composto central. A variação do teor de amilose (TA entre as farinhas de arroz torradas foi de 16-30g (100g-1, sendo que nos menores tempos de torra (até 13,3min e umidade acima de 18,5g (100g-1 observaram-se os maiores TA. Ocorreu elevação do índice de absorção de água (IAA à medida que aumentou o tempo de torra das farinhas de arroz. Os valores mais elevados de índice de solubilidade em água (ISA (25% foram encontrados para as farinhas de arroz com umidade acima de 22g (100g-1. Com o aumento do tempo de torra, ocorreu diminuição do pico de viscosidade, viscosidade final e de tendência a retrogradação das farinhas torradas. O contrário foi observado para a quebra de viscosidade. Conclui-se que a torração em micro-ondas pode ampliar as aplicações da farinha de arroz na indústria de alimentos em função das mudanças funcionais resultantes.Brazil is among the ten largest producers of rice in the world. Due to processing, most of the grains is broken, causing a by-product of low commercial value. Rice flour is usually produced from broken grains and used in manufactured products because of their functional properties. Aiming to obtain flours with different functional properties and thus

  11. Vertical distribution of phytoplankton functional groups in a tropical shallow lake: driving forces on a diel scale Distribuição vertical de grupos funcionais fitoplanctônicos em um lago tropical raso: forças direcionadoras em escala nictemeral

    Directory of Open Access Journals (Sweden)

    Luciana Gomes Barbosa

    2011-03-01

    pelos grupos S2 e Lo, persistentes durante a circulação, e compostos por cianobactérias filamentosas não fixadoras de N2 e dinoflagelados, respectivamente. A descontinuidade na distribuição vertical dos grupos funcionais com dominância de N A e F no epilímnio e de R e Lo no metalímnio e hipolímnio foi característica da estratificação, e diferenças entre períodos diurno e noturno não foram significativas. CONCLUSÕES: A redução em até 80% da biomassa do grupo NA durante a circulação indica a influência da estabilidade térmica e atelomixia parcial como fatores determinantes na compartimentalização dos grupos funcionais, restringindo a migração vertical diurna (MVD e a perda por sedimentação durante a estratificação.

  12. Evaluation of Serum HDL and LDL levels in Type II Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    K R Joshi

    2013-06-01

    Full Text Available   Introduction: Diabetes mellitus is a type of metabolic disorder characterized by hyperglycemia resulting from defect in insulin secretion, insulin action or both. This study intended to compare High Density Lipoprotein Cholesterol (HDL and Low Density Lipoprotein Cholesterol (LDL profile between type II diabetic and non-diabetic subjects and also find the correlation between HDL and LDL cholesterol in type II diabetic.   Methods: The study was conducted on 100 total subjects out of which experimental group with 50 subjects of known Type II Diabetes mellitus and control group with 50 subjects.   Results: The result of the present study suggests that fasting blood sugar and LDL cholesterol levels were increased but HDL cholesterol level was reduced in type II diabetic subjects when compared to controls.   Conclusion: The estimation of HDL cholesterol and LDL cholesterol in type II diabetes mellitus is very useful as it may serve as a useful parameter to monitor the prognosis of the patient.

  13. Structure-function relationships in reconstituted HDL: Focus on antioxidative activity and cholesterol efflux capacity.

    Science.gov (United States)

    Cukier, Alexandre M O; Therond, Patrice; Didichenko, Svetlana A; Guillas, Isabelle; Chapman, M John; Wright, Samuel D; Kontush, Anatol

    2017-09-01

    High-density lipoprotein (HDL) contains multiple components that endow it with biological activities. Apolipoprotein A-I (apoA-I) and surface phospholipids contribute to these activities; however, structure-function relationships in HDL particles remain incompletely characterised. Reconstituted HDLs (rHDLs) were prepared from apoA-I and soy phosphatidylcholine (PC) at molar ratios of 1:50, 1:100 and 1:150. Oxidative status of apoA-I was varied using controlled oxidation of Met112 residue. HDL-mediated inactivation of PC hydroperoxides (PCOOH) derived from mildly pre-oxidized low-density lipoprotein (LDL) was evaluated by HPLC with chemiluminescent detection in HDL+LDL mixtures and re-isolated LDL. Cellular cholesterol efflux was characterised in RAW264.7 macrophages. rHDL inactivated LDL-derived PCOOH in a dose- and time-dependent manner. The capacity of rHDL to both inactivate PCOOH and efflux cholesterol via ATP-binding cassette transporter A1 (ABCA1) increased with increasing apoA-I/PC ratio proportionally to the apoA-I content in rHDL. Controlled oxidation of apoA-I Met112 gradually decreased PCOOH-inactivating capacity of rHDL but increased ABCA1-mediated cellular cholesterol efflux. Increasing apoA-I content in rHDL enhanced its antioxidative activity towards oxidized LDL and cholesterol efflux capacity via ABCA1, whereas oxidation of apoA-I Met112 decreased the antioxidative activity but increased the cholesterol efflux. These findings provide important considerations in the design of future HDL therapeutics. Non-standard abbreviations and acronyms: AAPH, 2,2'-azobis(-amidinopropane) dihydrochloride; ABCA1, ATP-binding cassette transporter A1; apoA-I, apolipoprotein A-I; BHT, butylated hydroxytoluene; CV, cardiovascular; EDTA, ethylenediaminetetraacetic acid; HDL-C, high-density lipoprotein cholesterol; LOOH, lipid hydroperoxides; Met(O), methionine sulfoxide; Met112, methionine 112 residue; Met86, methionine 86 residue; oxLDL, oxidized low

  14. Dietary Almonds Increase Serum HDL Cholesterol in Coronary Artery Disease Patients in a Randomized Controlled Trial.

    Science.gov (United States)

    Jamshed, Humaira; Sultan, Fateh Ali Tipoo; Iqbal, Romaina; Gilani, Anwar Hassan

    2015-10-01

    More than one-half of coronary artery disease (CAD) patients have low HDL cholesterol despite having well-managed LDL cholesterol. Almond supplementation has not been shown to elevate circulating HDL cholesterol concentrations in clinical trials, perhaps because the baseline HDL cholesterol of trial subjects was not low. This clinical trial was designed to test the effect of almond supplementation on low HDL cholesterol in CAD patients. A total of 150 CAD patients (50 per group), with serum LDL cholesterol ≤100 mg/dL and HDL cholesterol ≤40 mg/dL in men and ≤50 mg/dL in women, were recruited from the Aga Khan University Hospital. After recording vital signs and completing a dietary and physical activity questionnaire, patients were randomly assigned to 1 of the following 3 groups: the no-intervention group (NI), the Pakistani almonds group (PA), and the American almonds group (AA). The respective almond varieties (10 g/d) were given to patients with instructions to soak them overnight, remove the skin, and eat them before breakfast. Blood samples for lipid profiling, body weight, and blood pressure were collected, and assessment of dietary patterns was done at baseline, week 6, and week 12. Almonds significantly increased HDL cholesterol. At weeks 6 and 12, HDL cholesterol was 12-14% and 14-16% higher, respectively, in the PA and AA than their respective baselines. In line with previous reports, serum concentrations of total cholesterol, triglycerides, LDL cholesterol, and VLDL cholesterol; total-to-HDL and LDL-to-HDL cholesterol ratios, and the atherogenic index were reduced in both the PA and AA at weeks 6 and 12 compared with baseline (P almond groups. Dietary patterns, body weight, and blood pressure did not change in any of the 3 groups during the trial. A low dose of almonds (10 g/d) consumed before breakfast can increase HDL cholesterol, in addition to improving other markers of abnormal lipid metabolism in CAD patients with low initial HDL cholesterol

  15. Síndrome do ceco móvel e as doenças gastrintestinais funcionais Mobile cecum sindrome and the functional gastrointestinal illnesses

    Directory of Open Access Journals (Sweden)

    Júlio César Monteiro dos Santos Jr.

    2006-12-01

    Full Text Available O ceco móvel é uma variação anatômica embriológica do ceco e cólon ascendente resultante da descida incompleta desses segmentos do intestino grosso e da não fixação no peritônio da goteira parieto-cólica direita. A falta dessa fusão permite movimentação do ceco e/ou do cólon ascendente, facilitando a torção sobre seu eixo longitudinal ou a dobra medial do ceco sobre si, ficando encostado com sua borda medial à borda medial do cólon ascendente. Esse fato causa sintomas intermitentes de obstrução parcial do intestino ou, no caso de torção completa (volvo, de obstrução aguda com possível necrose do segmento envolvido. A anormalidade embriológica tem alta incidência (10 a 30% na população, contudo só tem sido mencionada por ocasião da torção completa, inadequadamente denominada de volvo do ceco-ascendente, em geral com necrose cecal. Dessa forma, a ocorrência não é das mais comuns e está citada entre as causas de obstrução intestinal aguda, perfazendo, nos adultos e nas crianças, menos do que 2% de todos os casos de obstruções intestinais, mas com a importância de destaque por causa do alto índice de morbi-mortalidade entre os pacientes afetados. O objetivo foi apresentar o ceco móvel como causa de dor abdominal intermitente, distensão, empachamento e cólica de origens obscuras em pessoas de aparência saudável, mas com uma longa história de distúrbios gastrintestinais funcionais, associados à constipação e/ou diarréia, portanto, com um quadro sintomatológico sobreponível ao da síndrome do cólon irritável. Além disso, propomos um marcador anatômico para a síndrome do cólon irritável, seja o subtipo com constipação predominante, seja o da diarréia predominante ou a forma em que há alternância entre constipação e diarréia e a possibilidade de alívio daqueles sintomas com a cecopexia.Functional gastrointestinal (FGI disorders are chronic or periodic conditions characterized by

  16. Systemic functional translation studies (sfts: the theory travelling in brazilian environments Estudos sistêmico funcionais em tradução (TSFs: a teoria viajando no contexto brasileiro

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Vasconcellos

    2009-01-01

    Full Text Available This paper presents a mapping of the Systemic Functional Translation Studies (SFTS tradition in the Brazilian environment, from its genesis up to developments in the 2000's. While studies during the earlier period are informed by the concept of "translation as (retextualization", more recent SFTS research can be charted along the 'cline of instantiation', translations being investigated as "instantiations-in-contexts", cross-lingual functional varieties of language, or still as sources of SFL-based language description of Brazilian Portuguese. From late 90's on, computerized corpora and corpus-based methodologies have been integrated into Brazilian SFTS, for which annotation methods for the tagging of SFL categories have been developed. The paper ends with a consideration of Brazilian SFTS against the background of international SFTS as disseminated in the 2nd HCLS.Este trabajo presenta un mapeo de los Estudios de Traducción Sistémico-Funcionales en Brasil, desde su origen hasta la década de 2000. En el período inicial, los estudios se basan en el concepto de "traducción como (retextualización"; más recientemente, la investigación puede ubicarse a lo largo del "continuo de la instanciación" y las traducciones, estudiadas como "instanciaciones en contexto", variedades funcionales entre lenguas diferentes, o como fuentes de descripciones de base sistémico-funcional del portugués brasileño (PB. A partir de los ´90, se integraron a la investigación brasileña los corpora computarizados y las metodologías de corpus, para los que se desarrollaron específicamente códigos de anotación de base sistémico-funcional. El trabajo finaliza con una comparación de la investigación en Brasil y la del contexto internacional, divulgada en el Segundo Congreso HCLS, en 2008.Este trabalho apresenta um mapeamento dos Estudos da Tradução Sistêmico-Funcionais no Brasil, desde sua origem até a década de 2000. No período inicial, os estudos s

  17. Effect of uremia on HDL composition, vascular inflammation, and atherosclerosis in wild-type mice

    DEFF Research Database (Denmark)

    Bang, Christian A; Bro, Susanne; Bartels, Emil D

    2007-01-01

    Wild-type mice normally do not develop atherosclerosis, unless fed cholic acid. Uremia is proinflammatory and increases atherosclerosis 6- to 10-fold in apolipoprotein E-deficient mice. This study examined the effect of uremia on lipoproteins, vascular inflammation, and atherosclerosis in wild...... in cholic acid-fed sham mice. The results suggest that moderate uremia neither induces aortic inflammation nor atherosclerosis in C57BL/6J mice despite increased LDL/HDL cholesterol ratio and altered HDL composition....

  18. Relationship TG/HDL-C and insulin resistance in adult women by nutritional status

    Directory of Open Access Journals (Sweden)

    Lorena Belén

    2014-04-01

    Full Text Available Introduction: The ratio assessment TG/HDL-C is an indicator of LDL size, facilitating the detection of individuals with increased atherogenic risk. Estimating the size of the LDL becomes important, especially in patients with TG values near the upper limit of normal values of reference and HDL-C. The objective of the study is to estimate the association between TG/HDL-C and insulin resistance (IR by nutritional status in adult women attending the Foundation for Endocrine Metabolic Diseases Research and Applied Clinical Research (FIEEM.Material and methods: Design Cross-sectional, non-pregnant adult women, apparently healthy, older than 30 years old, attending FIEEM in the Autonomous City of Buenos Aires. Dependent variable: TG/HDL-C ≥ 3.0 considered high value. Independent variables: IR by homeostatic model index HOMA-IR ≥ 2.5 categorizing the sample into two groups: with and without IR, and controlled by nutritional status using body mass index (BMI and waist circumference (CC. SPSS Statistics 15.0, calculating X2 or Fisher exact test, OR with confidence intervals of 95% and establishing logistic regression p value < 0.05.Results: We evaluated a purposive sample of 104 women (31.4% and 26% IR with TG/HDL-C high. 84.6% were overweight or obese and 88.5% increased CC. Women with BMI had significantly increased 0.15-fold increased risk (95% CI = 0.01 to 1.26 for TG/HDL-C high (p = 0.04 than the control women. There was no significance with increased CC. The ratio TG/HDL-C high IR was significantly correlated (r = 0.30 p = 0.002.Conclusions: Body weight was significantly associated with IR and the ratio TG/HDL-C increased. This ratio correlated significantly with IR in apparently healthy women.

  19. Relations between particle size of HDL and LDL lipoproteins and cholesterol esterification rate

    Czech Academy of Sciences Publication Activity Database

    Dobiášová, Milada; Urbanová, Z.; Šamánek, M.

    2005-01-01

    Roč. 54, č. 2 (2005), s. 159-165 ISSN 0862-8408 R&D Projects: GA MZd(CZ) NA6590; GA MZd(CZ) NR8328 Institutional research plan: CEZ:AV0Z5011922 Keywords : particle size of lipoproteins * FER(HDL) * Log(TG/HDL-C) Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 1.806, year: 2005

  20. Association between triglyceride/HDL cholesterol ratio and carotid atherosclerosis in postmenopausal middle-aged women.

    Science.gov (United States)

    Masson, Walter; Siniawski, Daniel; Lobo, Martín; Molinero, Graciela; Huerín, Melina

    2016-01-01

    The triglyceride/HDL cholesterol ratio, as a surrogate marker of insulin resistance, may be associated to presence of subclinical carotid atherosclerosis in postmenopausal women. The aim of this study was to explore this association. Women (last menstrual period≥2 years) in primary prevention up to 65 years of age were recruited. Association between the triglyceride/HDL cholesterol (HDL-C) ratio and presence of carotid plaque, assessed by ultrasonography, was analyzed. ROC analysis was performed, determining the precision of this ratio to detect carotid plaque. A total of 332 women (age 57±5 years) were recruited. Triglyceride/HDL-C ratio was 2.35±1.6. Prevalence of carotid plaque was 29%. Women with carotid plaque had higher triglyceride/HDL-C ratios (3.33±1.96 vs. 2.1±1.2, P<.001) than women with no carotid plaque. A positive relationship was seen between quintiles of this ratio and prevalence of carotid plaque (p<.001). Regardless of other risk factors, women with higher triglyceride/HDL-C ratios were more likely to have carotid plaque (odds ratio 1.47, 95% confidence interval 1.20-1.79, P<.001). The area under the curve of the triglyceride/HDL-C ratio to detect carotid plaque was .71 (95% confidence interval .65 to .76), and the optimal cut-off point was 2.04. In postmenopausal women in primary prevention, insulin resistance, estimated from the triglyceride/HDL-C ratio, was independently associated to a greater probability of carotid plaque. A value of such ratio greater than 2 may be used for assessing cardiovascular risk in this particular group of women. Copyright © 2016 SEEN. Publicado por Elsevier España, S.L.U. All rights reserved.

  1. Original Paper Performances comparées du HDL-cholestérol et du ...

    African Journals Online (AJOL)

    CT/HDL-C) et du HDL-Cholestérol est le meilleur prédicteur du SMet chez les adultes béninois. .... (Canada) et du. Ministère de la Santé du Bénin. Le consentement éclairé écrit a été obtenu de chaque participant avant leur recrutement dans.

  2. How much does HDL cholesterol add to risk estimation? A report from the SCORE Investigators.

    LENUS (Irish Health Repository)

    Cooney, Marie Therese

    2009-06-01

    Systematic COronary Risk Evaluation (SCORE), the risk estimation system recommended by the European guidelines on cardiovascular disease prevention, estimates 10-year risk of cardiovascular disease mortality based on age, sex, country of origin, systolic blood pressure, smoking status and either total cholesterol (TC) or TC\\/high-density lipoprotein cholesterol (HDL-C) ratio. As, counterintuitively, these two systems perform very similarly, we have investigated whether incorporating HDL-C and TC as separate variables improves risk estimation.

  3. High plasma HDL-C attenuates stress hyperglycemia during acute phase of myocardial infarction.

    Science.gov (United States)

    Carvalho, Luiz Sergio F; Cintra, Riobaldo M R; Moura, Filipe A; Martins, Naiara V G; Quinaglia E Silva, Jose C; Coelho, Otavio R; Sposito, Andrei C

    2012-01-01

    During myocardial infarction (MI), a transient decrease of both insulin sensitivity and secretion triggers stress hyperglycemia, which is followed by a substantial increase in mortality. Recent findings in cellular models indicate that HDL may act on glucose homeostasis by improving insulin sensitivity and secretion. In this study, we explored this potential effect in patients during the acute phase of MI. Plasma glucose, insulin and C-peptide were measured at admission in the first 24h and on the fifth day after MI with ST-segment elevation in 183 consecutive non-diabetic patients. Patients were divided into HDL-C quartiles for the analyses (Q1: 47mg/dL). The Homeostasis Model Assessment version 2 was used to assess insulin sensitivity (HOMA2S) and beta-cell function (HOMA2B). On admission, no difference was found between the quartiles in glucose (p=0.6), insulin (p=0.6) or C-peptide (p=0.5) levels, HOMA2S (p=0.9) or HOMA2B (p=1.0). On the fifth day there was a reduction in glucose levels whose intensity was directly proportional to the HDL-C quartile (p<0.001). At the same time, there was a reduction in plasma insulin (p<0.001) and C-peptides (p<0.001) whose magnitude was inversely proportional to the HDL-C quartile. Consistently, the increase of HOMA2S (p<0.001) and HOMA2B (p=0.01) were also positively associated with HDL-C levels. Furthermore, plasma HDL-C levels were inversely and independently associated with blood glucose change during the acute phase. This study demonstrates the association between low plasma HDL-C levels and increased duration of stress hyperglycemia during MI and suggests in humans the interaction between HDL and insulin secretion and sensitivity. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  4. Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

    Science.gov (United States)

    Zagayko, Andriy L.; Kravchenko, Ganna B.; Krasilnikova, Oksana A.; Ogai, Yuri O.

    2013-01-01

    HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from “Enoant” obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle. It was shown that total lipids and triacylglycerol (TG) levels were higher in 24-month-old animals. In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group. The plasma HDL paraoxonase (PON) and lecithin:cholesterol acyltransferase (LCAT) activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP) activity was higher in old rats. Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats. After “Enoant” administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats. PMID:23936611

  5. Grape polyphenols increase the activity of HDL enzymes in old and obese rats.

    Science.gov (United States)

    Zagayko, Andriy L; Kravchenko, Ganna B; Krasilnikova, Oksana A; Ogai, Yuri O

    2013-01-01

    HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from "Enoant" obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle. It was shown that total lipids and triacylglycerol (TG) levels were higher in 24-month-old animals. In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group. The plasma HDL paraoxonase (PON) and lecithin:cholesterol acyltransferase (LCAT) activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP) activity was higher in old rats. Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats. After "Enoant" administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats.

  6. Therapeutic targets to raise HDL in patients at risk or with coronary artery disease.

    Science.gov (United States)

    Lüscher, Thomas F; von Eckardstein, Arnold; Simic, Branko

    2012-11-01

    The plasma levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Traditional HDL-raising therapies, like fibrates, PPAR-γ agonists, and nicacin, among others, are associated with undesirable side effects, limited efficacy, or have not yet been shown to improve morbidity and mortality on top of statins in clinical outcome trials. A novel pharmacological target for raising circulating HDL-C levels is the cholesterol ester transfer protein (CETP), an enzyme that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. Four pharmacological small-molecule inhibitors of CETP, i.e. torcetrapib (Pfizer), dalcetrapib (JTT-705; Roche), anacetrapib (Merck), and evacetrapib (Eli Lilly) have been developed. Notwithstanding a marked increase in HDL, torcetrapib was associated with an increase in all-cause mortality in the ILLUMINATE trial and raised safety concerns related to the off-target effects of CETP inhibition. Most recently, development of dalcetrapib was abruptly stopped due to a lack of clinically meaningful efficacy. Thus, it will be of utmost importance to demonstrate that the remaining CETP inhibitors in development not only increase HDL-C levels in plasma, but also improve HDL-function in patients with coronary disease or an acute coronary syndrome.

  7. Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events

    International Nuclear Information System (INIS)

    Cho, Sung Woo; Kim, Byung Gyu; Kim, Byung Ok; Byun, Young Sup; Goh, Choong Won; Rhee, Kun Joo; Kwon, Hyuck Moon; Lee, Byoung Kwon

    2016-01-01

    Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients

  8. Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Sung Woo [Division of Cardiology - Department of Internal Medicine - Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Division of Cardiology - Department of Medicine - Samsung Medical Center, Seoul (Korea, Republic of); Kim, Byung Gyu; Kim, Byung Ok; Byun, Young Sup; Goh, Choong Won; Rhee, Kun Joo [Division of Cardiology - Department of Internal Medicine - Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Kwon, Hyuck Moon; Lee, Byoung Kwon, E-mail: cardiobk@yuhs.ac [Division of Cardiology - Department of Internal Medicine - Gangnam Severance Hospital - Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2016-01-15

    Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients.

  9. Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

    Directory of Open Access Journals (Sweden)

    Andriy L. Zagayko

    2013-01-01

    Full Text Available HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from “Enoant” obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle. It was shown that total lipids and triacylglycerol (TG levels were higher in 24-month-old animals. In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group. The plasma HDL paraoxonase (PON and lecithin:cholesterol acyltransferase (LCAT activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP activity was higher in old rats. Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats. After “Enoant” administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats.

  10. Apolipoprotein M predicts pre-beta-HDL formation: studies in type 2 diabetic and nondiabetic subjects

    DEFF Research Database (Denmark)

    Plomgaard, P; Dullaart, R P F; de Vries, R

    2009-01-01

    protein (PLTP) activity and the ability of plasma to promote cholesterol efflux from cultured fibroblasts. RESULTS: ApoM was approximately 9% lower in patients with type 2 diabetes compared to controls (0.025 +/- 0.006 vs. 0.027 +/- 0.007 g L(-1), P = 0.01). The difference in apoM was largely attributable...... diabetes. Pre-beta-HDL and pre-beta-HDL formation are positively associated with apoM, supporting the hypothesis that apoM plays a role in HDL remodelling in humans. Lower apoM may provide a mechanism to explain why pre-beta-HDL formation is not increased in type 2 diabetes despite elevated PLTP activity.......OBJECTIVE: Studies in mice suggest that plasma apoM is lowered in hyperinsulinaemic diabetes and that apoM stimulates formation of pre-beta-HDL. Pre-beta-HDL is an acceptor of cellular cholesterol and may be critical for reverse cholesterol transport. Herein, we examined whether patients with type...

  11. High ratio of triglycerides to hdl-cholesterol predicts extensive coronary disease

    Directory of Open Access Journals (Sweden)

    Protasio Lemos da Luz

    2008-01-01

    Full Text Available An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c indicates an atherogenic lipid profile and a risk for the development of coronary disease. OBJECTIVE: To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease. METHODS: High-risk patients (n = 374 submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index. RESULTS: The subjects consisted of 220 males and 154 females, age 57.2 ± 11.1 years, with total cholesterol of 210± 50.3 mg/dL, triglycerides of 173.8 ± 169.8 mg/dL, HDL-cholesterol (HDL-c of 40.1 ± 12.8 mg/dL, LDL-cholesterol (LDL-c of 137.3 ± 46.2 mg/dL, TG/HDL-c of 5.1 ± 5.3, and a Friesinger index of 6.6 ± 4.7. The relationship between the extent of coronary disease (dichotomized by a Friesenger index of 5 and lipid levels (normal vs. abnormal was statistically significant for the following: triglycerides, odds ratio of 2.02 (1.31-3.1; p = 0.0018; HDL-c, odds ratio of 2.21 (1.42-3.43; p = 0.0005; and TG/HDL-c, odds ratio of 2.01(1.30-3.09; p = 0.0018. However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p = 0.33] or LDL-c [1.47 (0.96-2.25; p = 0.0842]. The chi-square for linear trends for Friesinger > 4 and lipid quartiles was statistically significant for triglycerides (p = 0.0017, HDL-c (p = 0.0001, and TG/HDL-c (p = 0.0018, but not for total cholesterol (p = 0.393 or LDL-c (p = 0.0568. The multivariate analysis by logistic regression OR gave 1.3 ± 0.79 (p = .0001 for TG/HDL-c, 0.779 ± 0.074 (p = .0001 for HDL-c, and 1.234 ± 0.097 (p = 0.03 for LDL. Analysis of receiver operating characteristic curves showed that only TG/HDL-c and HDL-c were useful for detecting extensive coronary disease, with the former more strongly associated with disease. CONCLUSIONS: Although some lipid variables were associated with the extent of

  12. O efeito da reeducação postural global no tratamento da lombalgia durantes a gestação

    OpenAIRE

    Vinicius Fernandes Barrionuevo Gil

    2009-01-01

    Resumo: A dor lombar é considerada distúrbio comum na população em geral e é queixa frequente durante a gestação. Estudos recentes mostram que aproximadamente 80% das gestantes relatam dores nas regiões lombar e pélvica, sendo que 51% apresentam dor que interfere significativamente em suas atividades físicas e qualidade de vida. Objetivo: Avaliar o efeito da Reeducação Postural Global (RPG) no tratamento da lombalgia durante a gravidez e sua associação com as limitações funcionais das gestant...

  13. Aceitação e percepção dos estudantes de gastronomia e nutrição em relação aos alimentos funcionais
    Acceptance and perception of gastronomy and nutrition students regarding functional foods

    Directory of Open Access Journals (Sweden)

    G. R. C. MELO

    2010-12-01

    Full Text Available

    O termo “alimento funcional” foi introduzido no Japão (1980 e, apesar de comumente utilizado, ainda não existe defi nição mundialmente aceita. Estudos afirmam que sua aceitação está relacionada à informação recebida. Assim, profi ssionais da área de alimentos devem divulgar informações acerca de seus benefícios para promoção de alimentação saudável. Portanto, buscou-se verifi car aceitação e percepção dos alunos de Gastronomia e Nutrição do DF em relação aos “alimentos funcionais” por meio de estudo transversal com questões fechadas e posterior análise estatística. Foram aplicados 128 questionários: 80 em estudantes de nutrição (EN e 48 em estudantes de gastronomia (EG. Dos estudantes de nutrição (EN, 100% já ouviram falar sobre “alimentos funcionais” e sabe seu significado. Dos estudantes de Gastronomia (EG, 23% desconheciam o termo e, com isso, este percentual foi excluído da pesquisa, restando um universo de 117 respondentes. Apenas 22% dos EN não realizam pesquisas relativas ao assunto, assim como 42% dos EG. Quanto à prevenção de doenças 96% EN e 89% EG acreditam que seja possível por meio da ingestão regular desses alimentos. Porém, apenas 29% EN e 38% EG comprariam um alimento desconhecido sabendo que ele possui alegação de propriedade funcional ou de saúde. Além disso, 50% EN e 70% EG acreditam que o sabor de um alimento é mais importante que seus efeitos na saúde. Da mesma forma, 56% EN e 54% EG não comprariam um “alimento funcional” sem conhecer o seu sabor. Portanto, observa-se que os alunos estão cientes da importância do consumo de alimentos que possam promover saúde e prevenir o surgimento de doenças. Porém, ao optar por utilizar esses alimentos, se deparam com fatores como a

  14. Egg consumption modulates HDL lipid composition and increases the cholesterol-accepting capacity of serum in metabolic syndrome.

    Science.gov (United States)

    Andersen, Catherine J; Blesso, Christopher N; Lee, Jiyoung; Barona, Jacqueline; Shah, Dharika; Thomas, Michael J; Fernandez, Maria Luz

    2013-06-01

    We recently demonstrated that daily whole egg consumption during moderate carbohydrate restriction leads to greater increases in plasma HDL-cholesterol (HDL-C) and improvements in HDL profiles in metabolic syndrome (MetS) when compared to intake of a yolk-free egg substitute. We further investigated the effects of this intervention on HDL composition and function, hypothesizing that the phospholipid species present in egg yolk modulate HDL lipid composition to increase the cholesterol-accepting capacity of subject serum. Men and women classified with MetS were randomly assigned to consume either three whole eggs (EGG, n = 20) per day or the equivalent amount of egg substitute (SUB, n = 17) throughout a 12-week moderate carbohydrate-restricted (25-30 % of energy) diet. Relative to other HDL lipids, HDL-cholesteryl ester content increased in all subjects, with greater increases in the SUB group. Further, HDL-triacylglycerol content was reduced in EGG group subjects with normal baseline plasma HDL-C, resulting in increases in HDL-CE/TAG ratios in both groups. Phospholipid analysis by mass spectrometry revealed that HDL became enriched in phosphatidylethanolamine in the EGG group, and that EGG group HDL better reflected sphingomyelin species present in the whole egg product at week 12 compared to baseline. Further, macrophage cholesterol efflux to EGG subject serum increased from baseline to week 12, whereas no changes were observed in the SUB group. Together, these findings suggest that daily egg consumption promotes favorable shifts in HDL lipid composition and function beyond increasing plasma HDL-C in MetS.

  15. Spirulina platensis effects on the levels of total cholesterol, HDL and triacylglycerols in rabbits fed with a hypercholesterolemic diet

    Directory of Open Access Journals (Sweden)

    Luciane Maria Colla

    2008-04-01

    Full Text Available In this work, hypercholesterolemia was induced in rabbits by feeding them a high cholesterol diet (CD, 350 mg/d and the effects of supplementing this diet with 0.5 g/d Spirulina platensis was evaluated by measuring the levels of serum total-cholesterol (TC, triacylglycerols (TAG and high-density lipoprotein (HDL-cholesterol at the start of the experiment and after 30 d and 60 d. It was found that the levels of serum cholesterol decreased from 1,054±101 mg.dL-1 in the rabbits fed a CD without S. platensis to 516±163 mg.dL-1 to those fed with a high cholesterol diet supplemented with S. platensis (significant at p A microalga Spirulina é cultivada e comercializada no mundo devido a suas características nutricionais (elevada concentração de proteínas, em torno de 65%, vitaminas e sais minerais e ao seu potencial terapêutico no tratamento de inúmeras doenças, inclusive a hipercolesterolemia. Neste trabalho foi avaliada a inibição da hipercolesterolemia induzida em coelhos por uma dieta adicionada de colesterol (350 mg.d-1, pela suplementação de 0,5 g.dia-1 de biomassa de Spirulina platensis, sendo avaliados os níveis de colesterol total, triglicerídeos e HDL nos tempos de 0 d, 30 d e 60 d de tratamento. Os resultados indicaram que a adição de Spirulina platensis na dieta ocasionou decréscimo nos níveis de colesterol total de 1054±101 mg.dL-1 para 516±163 mg.dL-1 (p<0,0001, para os coelhos alimentados com a dieta colesterolêmica em comparação com os que receberam a dieta adicionada de Spirulina platensis. A adição de Spirulina a dieta colesterolêmica não ocasionou decréscimo significativo nos níveis de triglicerídios dos coelhos. Os valores de HDL aumentaram de 73±31 mg.dL-1 para 91,0±15,7 mg.dL-1, comparando-se os coelhos alimentados com a dieta colesterolêmica e os alimentados com a dieta adicionada de Spirulina, estatisticamente diferentes a um nível de significância maior que 0,1533.

  16. Low HDL cholesterol is correlated to the acute ischemic stroke with diabetes mellitus.

    Science.gov (United States)

    Luo, Yun; Li, Jingwei; Zhang, Junfeng; Xu, Yun

    2014-11-14

    To clarify the role of lipid composition in the occurrence of acute ischemic stroke (AIS) with diabetes mellitus (DM) and its influence factors. Data was collected from the patients hospitalization in Affiliated Drum Tower Hospital of Nanjing University Medical School from October 2008 to May 2012, which included AIS and non-AIS consist of transient ischemic attack (TIA) and Vertigo or dizzy. Lipid and other risk factors including blood glucose (BG), uric acid (UA), hypertension, DM and atrial fibrillation (AF) were investigated in relation to occurrence of AIS. The level of high density lipoprotein (HDL) cholesterol was decreased obviously in the DM group compared to the non-DM group and low level of HDL cholesterol was prevalent in the AIS patients with DM. logistic regression demonstrated that decreased HDL cholesterol was correlated to the AIS with DM, not all AIS, and the relative risk of ischemic stroke in low HDL cholesterol level group was 2.113 (95% CI = 1.191-3.749, P = 0.011) compared to the high level group. Furthermore, age has the obviously impact on it. HDL cholesterol was correlated to the AIS with DM just in the populations of aged ≦70 years (OR = 0.192, P = 0.000), low level of HDL cholesterol had more high risk of ischemic stroke than that in the high level group (OR = 6.818, P = 0.002). Decreased HDL cholesterol was correlated to the occurrence of AIS with DM, especially in the populations of aged ≦70 years.

  17. Characterization of immortalized human dermal microvascular endothelial cells (HMEC-1) for the study of HDL functionality.

    Science.gov (United States)

    Muñoz-Vega, Mónica; Massó, Felipe; Páez, Araceli; Carreón-Torres, Elizabeth; Cabrera-Fuentes, Hector A; Fragoso, José Manuel; Pérez-Hernández, Nonanzit; Martinez, Laurent O; Najib, Souad; Vargas-Alarcón, Gilberto; Pérez-Méndez, Óscar

    2018-03-09

    Primary cultures endothelial cells have been used as models of endothelial related diseases such atherosclerosis. Biological behavior of primary cultures is donor-dependent and data could not be easily reproducible; endothelial cell lines are emerging options, particularly, human dermal microvascular endothelial cells (HMEC-1), that should be validated to substitute primary cultures for the study of HDL functions. Morphology, size and granularity of cells were assessed by phase contrast microscopy and flow cytometry of HMEC-1. The adhesion molecules, ICAM-1and VCAM-1 after TNF-α stimulation, and endothelial markers CD105 endoglin, as well as HDL receptor SR-BI were determined by flow cytometry. Internalization of HDL protein was demonstrated by confocal microscopy using HDL labeled with Alexa Fluor 488. HUVECs were used as reference to compared the characteristics with HMEC-1. HMEC-1 and HUVEC had similar morphologies, size and granularity. HMEC-1 expressed endothelial markers as HUVECs, as well as functional SR-B1 receptor since the cell line was able to internalize HDL particles. HMEC-1 effectively increased ICAM-1 and VCAM-1 expression after TNF-α stimulation. HUVECs showed more sensibility to TNF-α stimulus but the range of ICAM-1 and VCAM-1 expression was less homogeneous than in HMEC-1, probably due to biological variation of the former. Finally, the expression of adhesion molecules in HMEC-1 was attenuated by co-incubation with HDL. HMEC-1 possess characteristics of endothelial cells, similar to HUVECs, being a cell line suitable to evaluate the functionality of HDL vis-à-vis the endothelium.

  18. Differences in the triglyceride to HDL-cholesterol ratio between Palestinian and Israeli adults.

    Directory of Open Access Journals (Sweden)

    Ram Weiss

    Full Text Available AIMS: To evaluate differences in the triglyceride to HDL-cholesterol ratio (TG/HDL, thought to be a proxy measure of insulin resistance, between Palestinian and Israeli adults in view of the greater incidence of coronary heart disease and high prevalence of diabetes in Palestinian Arabs. RESEARCH METHODS: A population-based observational prevalence study of cardiovascular and diabetes risk factors in Jerusalem. Participants (968 Palestinians, 707 Israelis, sampled at ages 25-74 years underwent fasting and 2 h post-75 g oral challenge plasma glucose determinations. Metabolic risk was assessed using the surrogate index TG/HDL. Sex-specific comparisons were stratified by categories of body mass index and sex-specific waist circumference quartiles, adjusted by regression for age, glucose tolerance status and use of statins. RESULTS: Prevalence of overweight and obesity was substantially larger in Palestinians (p = 0.005. Prevalence of diabetes was 2.4 and 4 fold higher among Palestinian men and women, respectively (p<0.001. Adjusted TG/HDL was higher in Palestinians than Israelis across BMI and waist circumference categories (p<0.001 for both. Higher TG/HDL in Palestinians persisted in analyses restricted to participants with normal glucose tolerance and off statins. Notably, higher TG/HDL among Palestinians prevailed at a young age (25-44 years and in normal weight individuals of both sexes. CONCLUSIONS: Palestinians have a higher TG/HDL ratio than Israelis. Notably, this is evident also in young, healthy and normal weight participants. These findings indicate the need to study the determinants of this biomarker and other measures of insulin resistance in urban Arab populations and to focus research attention on earlier ages: childhood and prenatal stages of development.

  19. A família do p53: aspectos estruturais e funcionais do p73 e do p63 The p53 family: structural and functional aspects of p73 and p63

    Directory of Open Access Journals (Sweden)

    Alfredo Ribeiro-Silva

    2003-06-01

    Full Text Available O p53 é um gene regulador chave do ciclo celular que, quando sofre mutações, leva ao desenvolvimento de neoplasias, atuando, portanto, como um gene supressor tumoral em condições normais. Recentemente foram identificados genes homólogos ao p53 denominados p73 e p63, provavelmente oriundos de um gene ancestral comum. Apesar da grande homologia estrutural, os membros da família do p53 possuem diferenças funcionais entre si. O presente artigo tem por finalidade discorrer sobre os principais aspectos estruturais e funcionais do p73 e do p63, ressaltando seus papéis na tumorigênese humana. O p73 ativa vários genes responsivos ao p53 e, quando superexpresso, inibe a ação do p53. Raramente encontra-se mutado em neoplasias, e seu papel na tumorigênese humana ainda é motivo de controvérsias. O p63 não é um gene supressor tumoral clássico, sendo essencial para a manutenção de uma população de células precursoras (células-tronco em vários tecidos epiteliais. O p63 marca as células basais de vários órgãos epiteliais, como a pele e a próstata, podendo ser considerado um marcador de indiferenciação celular. O p63 é um marcador recentemente descrito e ainda requer maior investigação para determinar seu papel no desenvolvimento de neoplasias em humanos.The p53 gene has a key role in the cell cycle control. When mutated, it promotes the development of neoplasms, acting in so far as a tumor suppressor gene in normal conditions. Recently, genes homologue to p53 were identified, named p73 e p63, probably originated from a common ancestral gene. Despite the great structural homology, the members of p53 family have functional differences. This article aims to discourse about the major structural and functional aspects of p73 and p63, reinforcing their role in human tumorigenesis. P73 activates several p53 responsive genes and, when overexpressed, inhibits the p53 action. It is rarely mutated in neoplasms and its role in human

  20. A estrutura da oração em línguas indígenas brasileiras

    Directory of Open Access Journals (Sweden)

    MAIA Marcus

    1999-01-01

    Full Text Available Compara-se neste artigo um conjunto de fatos relacionados a interface sintaxe/morfologia em quatro línguas indígenas brasileiras, a saber, Kuikuro, Guarani, Karaja e Tikuna. Investiga-se o papel das categorias funcionais na derivação da estrutura básica da oração nessas línguas. Discutem-se os problemas que se colocam para a linearização da ordem SOV, propondo-se análises alternativas.

  1. Obtenção de frações proteicas de sangue bovino : composição, valor nutritivo e propriedades funcionais

    OpenAIRE

    Renata Maria Teixeira Duarte

    1997-01-01

    Resumo: Este estudo objetivou o desenvolvimento de um processo de obtenção das proteínas do sangue de bovinos e a avaliação de suas propriedades funcionais e nutricionais, visando sua utilização em alimentação humana. Os estudos foram realizados com sangue oriundo de bovinos sadios, coletado no frigorífico Nova Odessa, Nova Odessa São Paulo, por punção direta no sistema arterial (arcus aortae). Foi utilizado citrato de sódio como anticoagulante e após a coleta o sangue foi centrifugado para s...

  2. Policentrismo, Áreas Urbanas Funcionais (FUAs e Dinâmica Territorial: Um estudo exploratório desde a região do Vale do Rio Pardo-RS-Brasil / Polycentric, Functional Urban Areas (FUAs and Territorial Dynamics: An exploratory study from the region of Vale do Rio Pardo-RS-Brazil

    Directory of Open Access Journals (Sweden)

    Rogerio Leandro Lima da Silveira

    2016-12-01

    Full Text Available Resumo Este artigo aborda o potencial metodológico e analítico do conceito de áreas urbanas funcionais (FUAs para os estudos urbanos e regionais, notadamente em relação ao seu uso para a análise e interpretação da dinâmica territorial em contextos regionais. Revisa-se os conceitos de policentrismo e áreas funcionais urbanas e sua aplicação na análise da dinâmica territorial na escala regional. Com base em estudo exploratório na região do Vale do Rio Pardo, no Estado do Rio Grande do Sul- Brasil, identifica-se, caracteriza-se e analisa-se as FUAS existentes no território regional, interpretando sua configuração espacial, seus principais fluxos e interações socioespaciais entre as cidades da região, decorrentes dos deslocamentos pendulares para trabalho e estudo. Observa-se a constituição de duas FUAs: a de Santa Cruz do Sul e a de Venâncio Aires, evidenciando um incipiente e desigual conteúdo policêntrico no território regional devido à orientação e à intensidade dos deslocamentos pendulares, que apontam a influência da cidade de Santa Cruz do Sul na dinâmica territorial e na rede urbana regional. Abstract This article discusses the methodological and analytical potential of the concept of functional urban areas (FUAS for urban and regional studies, notably in relation to its use for the analysis and interpretation of territorial dynamics in regional contexts. Revises the concepts of polycentrism and urban functional areas and its application in the analysis of territorial dynamics at the regional scale. Based on exploratory study in Rio Pardo Valley region in the state of Rio Grande do Sul-Brazil, identifies the existing functional urban areas in the regional territory is characterized and analyzed by interpreting their spatial configuration, its main flows and socio-spatial interactions between the towns of the region, resulting from commuting to work and study. Note the formation of two Fuas: the Santa Cruz do

  3. Triglycerides-to-HDL ratio as a new marker of endothelial dysfunction in obese prepubertal children.

    Science.gov (United States)

    de Giorgis, Tommaso; Marcovecchio, M Loredana; Di Giovanni, Ilaria; Giannini, Cosimo; Chiavaroli, Valentina; Chiarelli, Francesco; Mohn, Angelika

    2014-02-01

    To investigate whether there is an association of the triglyceride-to-HDL cholesterol (TG:HDL-C) ratio with cardiovascular risk factors and early signs of vascular damage in obese prepubertal children. In 50 obese (27 boys, 7.8±1.4 years) and 37 normal-weight (20 boys; 7.3±1.5 years) prepubertal children, anthropometric measurements, oxidative stress markers (urinary isoprostanes (PGF2α (prostaglandin F2α)), soluble receptor for advanced glycation end-products (sRAGE)) and insulin sensitivity (homeostasis model assessment of insulin resistance (HOMA-IR) and whole-body insulin sensitivity index (WBISI)) were evaluated. Lipids profile was assessed and the TG:HDL-C ratio was calculated. In addition, high-resolution ultrasound was performed to assess carotid intima-media thickness (cIMT). Obese children showed significantly higher values of the TG:HDL-C ratio (1.9±1.1 vs 1.2±0.6, P=0.002) compared with controls. After dividing the population in tertiles of the TG:HDL-C ratio (1.67), cIMT (P=0.0003), and HOMA-IR (P=0.0001) progressively increased from the lower to the upper tertile, whereas WBISI (P=0.0003) and sRAGE (P=0.05) progressively decreased. In a regression model, the TG:HDL ratio was significantly and positively associated with cIMT (r=0.493; P=0.0005). A cutoff point for TG:HDL-C ratio of 1.12 had 81% sensitivity and 49% specificity in the identification of children with cIMT values in the upper quartile (Area under the curve values from receiver operating characteristic curves=0.633±0.065, P=0.045). This study confirms the reliability of the TG:HDL-C ratio as a useful marker of cardiovascular risk. Interestingly, our results underline that the TG:HDL-C ratio is directly related with early signs of vascular damage already present in prepubertal children.

  4. Low serum hdl-c levels: a hidden threat to patients with spinal cord injury

    International Nuclear Information System (INIS)

    Ali, S.; Ayyub, A.

    2014-01-01

    To determine the serum lipid profile in patients with traumatic spinal cord injury (SCI) of duration >1 year and to compare the serum HDL-c levels of SCI patients undergoing regular physiotherapy for >60 minutes daily with those who did not Undergo physiotherapy. Study Design: Cross-sectional, comparative study. Place and Duration of Study: Spinal Cord Injury Department, AFIRM Rawalpindi and Department of Chemical Pathology, Army Medical College, Rawalpindi, from January 2013 to June 2013. Patients and Methods: Forty six patients suffering from traumatic spinal cord injury (SCI) were included. After recording the detailed medical history, fasting blood samples were obtained and analyzed for serum lipid profile. Dyslipidemias were assessed using guidelines from the National Cholesterol Education Project Adult Treatment Panel III (ATP III). Serum high-density lipoprotein cholesterol (HDL-c)< 0.9 mmol/l (40mg/dl) was considered as low HDL-c level. Results: Out of total 46 patients, 33 (71.7%) were male and 13 (28.3%) were females with mean age of 34.9+- 9.55 years. Low levels of serum HDL-c were found in 21 (45.7%) SCI patients (mean serum HDL-clevels: 0.97+-0.23). SCI patients were further categorized in two groups depending upon the status of regular physiotherapy. Statistically significant difference was found in mean serum HDL-c levels of 22 (47.82%) SCI patients undergoing regular physiotherapy as compared to 24 (52.18%) SCI patients who did not underwent physiotherapy (p<0.05). Conclusion: Patients with SCI have decreased levels of serum HDL-c, imparting an increased risk of cardiovascular disease (CVD) in these disabled persons. SCI individuals following regular physiotherapy, have better serum HDL-c levels as compared to bed-ridden SCI patients, suggesting the physical activity as an important factor to elevate the serum HDL-c in such patients. Knowledge of relative risk of CVD in persons with SCI is important for appropriate intervention alstrategies

  5. Effects of Carbohydrate and Dietary Fiber Intake, Glycemic Index and Glycemic Load on HDL Metabolism in Asian Populations.

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    Yanai, Hidekatsu; Katsuyama, Hisayuki; Hamasaki, Hidetaka; Abe, Shinichi; Tada, Norio; Sako, Akahito

    2014-10-01

    High-density lipoprotein (HDL) is a lipoprotein which has anti-atherogenic property by reverse cholesterol transport from the peripheral tissues to liver. Low HDL-cholesterol (HDL-C) levels are associated with the development of coronary artery diseases (CADs). Various epidemiological studies have suggested that the development of CAD increase in individuals with less than 40 mg/dL of HDL-C. In spite of accumulation of evidences which suggest a significant association between low HDL-C and cardiovascular diseases, effects of dietary factors on HDL metabolism remained largely unknown. There may be interracial differences in effects of dietary factors on HDL metabolism. Here we reviewed published articles about effects of carbohydrate and dietary fiber intake, glycemic index (GI) and glycemic load (GL), on HDL-C metabolism, regarding meta-analyses and clinical studies performed in Asian population as important articles. Low carbohydrate intake, GI and GL may be beneficially associated with HDL metabolism. Dietary fiber intake may be favorably associated with HDL metabolism in Asian populations.

  6. The LDL-HDL profile determines the risk of atherosclerosis: a mathematical model.

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    Wenrui Hao

    Full Text Available Atherosclerosis, the leading death in the United State, is a disease in which a plaque builds up inside the arteries. As the plaque continues to grow, the shear force of the blood flow through the decreasing cross section of the lumen increases. This force may eventually cause rupture of the plaque, resulting in the formation of thrombus, and possibly heart attack. It has long been recognized that the formation of a plaque relates to the cholesterol concentration in the blood. For example, individuals with LDL above 190 mg/dL and HDL below 40 mg/dL are at high risk, while individuals with LDL below 100 mg/dL and HDL above 50 mg/dL are at no risk. In this paper, we developed a mathematical model of the formation of a plaque, which includes the following key variables: LDL and HDL, free radicals and oxidized LDL, MMP and TIMP, cytockines: MCP-1, IFN-γ, IL-12 and PDGF, and cells: macrophages, foam cells, T cells and smooth muscle cells. The model is given by a system of partial differential equations with in evolving plaque. Simulations of the model show how the combination of the concentrations of LDL and HDL in the blood determine whether a plaque will grow or disappear. More precisely, we create a map, showing the risk of plaque development for any pair of values (LDL,HDL.

  7. A high-throughput screen for endothelial lipase using HDL as substrate.

    Science.gov (United States)

    Keller, Paul M; Rust, Timothy; Murphy, Dennis J; Matico, Rosalie; Trill, John J; Krawiec, John A; Jurewicz, Anthony; Jaye, Michael; Harpel, Mark; Thrall, Sara; Schwartz, Benjamin

    2008-07-01

    Endothelial lipase (EL) is a 482-amino-acid protein from the triglyceride lipase gene family that uses a Ser-His-Asp triad for catalysis. Its expression in endothelial cells and preference for phospholipids rather than triglycerides are unique. Animal models in which it is overexpressed or knocked out indicate EL levels are inversely correlated with high-density lipoprotein cholesterol (HDL-C). HDL-C is commonly referred to as the good form of cholesterol because it is involved in the reverse cholesterol transport pathway, in which excess cholesterol is effluxed from peripheral tissues for excretion or reabsorption. Thus, EL inhibition in humans is expected to lead to increases in HDL levels and possibly a decrease in cardiovascular disease. To discover inhibitors of EL, a coupled assay for EL has been developed, using its native substrate, HDL. Hydrolysis of HDL by EL yields free fatty acids, which are coupled through acyl-CoA synthetase, acyl-CoA oxidase, and horseradish peroxidase to produce the fluorescent species resorufin. This assay was developed into a 5-microL, 1536-well assay format, and a high-throughput screen was executed against the GSK collection. In addition to describing the screening results, novel post-HTS mechanism-of-action studies were developed for EL and applied to 1 of the screening hits as an example.

  8. Actualización en el manejo del colesterol hdl bajo

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    Rigotti R. Attilio, Dr.

    2012-11-01

    Full Text Available Los niveles plasmáticos bajos de colesterol transportado en las lipoproteínas de alta densidad (HDL constituyen un elemento independiente de riesgo cardiovascular ateroesclerótico. Algunos protocolos clínicos enfocados en el manejo farmacológico de los niveles bajos de colesterol HDL en pacientes de alto riesgo cardiovascular han mostrado resultados favorables. Por otro lado, existen nuevas formulaciones de la niacina, el agente farmacológico disponible más efectivo para el manejo del colesterol HDL bajo, y se están desarrollando nuevos fármacos más potentes para aumentar los niveles plasmáticos de colesterol HDL. En el futuro, nuevos medicamentos que modulen el metabolismo de HDL y demuestren beneficio sobre el control del riesgo cardiovascular ateroesclerótico, podrían mejorar aún más el manejo actual de esta condición patológica que se basa esencialmente en el uso de estatinas.

  9. A high throughput biochemical fluorometric method for measuring lipid peroxidation in HDL.

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    Theodoros Kelesidis

    Full Text Available Current cell-based assays for determining the functional properties of high-density lipoproteins (HDL have limitations. We report here the development of a new, robust fluorometric cell-free biochemical assay that measures HDL lipid peroxidation (HDLox based on the oxidation of the fluorochrome Amplex Red. HDLox correlated with previously validated cell-based (r = 0.47, p<0.001 and cell-free assays (r = 0.46, p<0.001. HDLox distinguished dysfunctional HDL in established animal models of atherosclerosis and Human Immunodeficiency Virus (HIV patients. Using an immunoaffinity method for capturing HDL, we demonstrate the utility of this novel assay for measuring HDLox in a high throughput format. Furthermore, HDLox correlated significantly with measures of cardiovascular diseases including carotid intima media thickness (r = 0.35, p<0.01 and subendocardial viability ratio (r = -0.21, p = 0.05 and physiological parameters such as metabolic and anthropometric parameters (p<0.05. In conclusion, we report the development of a new fluorometric method that offers a reproducible and rapid means for determining HDL function/quality that is suitable for high throughput implementation.

  10. Psicoses funcionais na infância e adolescência Functional psychosis in childhood and adolescence

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    Sérgio K. Tengan

    2004-04-01

    Full Text Available OBJETIVO: Revisar a literatura acerca das psicoses funcionais na infância e adolescência e permitir ao pediatra a possibilidade de reconhecer esta patologia em sua rotina de trabalho. FONTES DOS DADOS: As informações foram obtidas através de livros textos clássicos de psiquiatria, além de pesquisa nas bases de dados MEDLINE e Lilacs no período de 1993 a 2003. SÍNTESE DOS DADOS: O artigo foi estruturado em tópicos, procurando-se definir e classificar as psicoses na infância e adolescência, sendo a esquizofrenia a principal representante deste grupo. As dificuldades em seu diagnóstico na infância são ressaltadas, e as principais linhas de tratamento são abordadas. CONCLUSÃO: A esquizofrenia com início na infância é uma patologia rara, quase 50 vezes menos freqüente quando comparada com pacientes que iniciaram a doença com idade acima de 15 anos. É uma doença distinta do autismo infantil não somente por questões conceituais, mas por um embasamento na fenomenologia, genética, quadro clínico e neurológico associado.OBJECTIVE: To review the literature about functional psychosis in children and adolescents, allowing pediatricians to recognize the pathology in their daily work routine. SOURCES OF DATA: Classical textbooks of child and adolescent psychiatry; search of MEDLINE and Lilacs databases (1993 to 2003. Computerized search methods were combined with manual search of the literature. SUMMARY OF THE FINDINGS: This article is structured in topics, trying to define and classify psychosis in childhood and adolescence, with schizophrenia being the main disorder. The article stresses the difficulties for the diagnosis in children, and addresses the main treatment guidelines. CONCLUSION: Schizophrenia beginning in childhood, or very-early-onset schizophrenia, is a very rare pathology, almost 50-fold less frequent than early-onset schizophrenia (appearing at age 15 or later. Childhood-onset schizophrenia is a separate disorder

  11. Longitudinal study of alcohol consumption and HDL concentrations: a community-based study12

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    Li, Junjuan; Shearer, Gregory C; Lichtenstein, Alice H; Zheng, Xiaoming; Wu, Yuntao; Jin, Cheng; Wu, Shouling

    2017-01-01

    Background: In cross-sectional studies and short-term clinical trials, it has been suggested that there is a positive dose-response relation between alcohol consumption and HDL concentrations. However, prospective data have been limited. Objective: We sought to determine the association between total alcohol intake, the type of alcohol-containing beverage, and the 6-y (2006–2012) longitudinal change in HDL-cholesterol concentrations in a community-based cohort. Design: A total of 71,379 Chinese adults (mean age: 50 y) who were free of cardiovascular diseases and cancer and did not use cholesterol-lowering agents during follow-up were included in the study. Alcohol intake was assessed via a questionnaire in 2006 (baseline), and participants were classified into the following categories of alcohol consumption: never, past, light (women: 0–0.4 servings/d; men: 0–0.9 servings/d), moderate (women: 0.5–1.0 servings/d; men: 1–2 servings/d), and heavy (women: >1.0 servings/d; men: >2 servings/d). HDL-cholesterol concentrations were measured in 2006, 2008, 2010, and 2012. We used generalized estimating equation models to examine the associations between baseline alcohol intake and the change in HDL-cholesterol concentrations with adjustment for age, sex, smoking, physical activity, obesity, hypertension, diabetes, liver function, and C-reactive protein concentrations. Results: An umbrella-shaped association was observed between total alcohol consumption and changes in HDL-cholesterol concentrations. Compared with never drinkers, past, light, moderate, and heavy drinkers experienced slower decreases in HDL cholesterol of 0.012 mmol · L−1 · y−1 (95% CI: 0.008, 0.016 mmol · L−1 · y−1), 0.013 mmol · L−1 · y−1 (95% CI: 0.010, 0.016 mmol · L−1 · y−1), 0.017 mmol · L−1 · y−1 (95% CI: 0.009, 0.025 mmol · L−1 · y−1), and 0.008 mmol · L−1 · y−1 (95% CI: 0.005, 0.011 mmol · L−1 · y−1), respectively (P alcohol consumption was

  12. Longitudinal study of alcohol consumption and HDL concentrations: a community-based study.

    Science.gov (United States)

    Huang, Shue; Li, Junjuan; Shearer, Gregory C; Lichtenstein, Alice H; Zheng, Xiaoming; Wu, Yuntao; Jin, Cheng; Wu, Shouling; Gao, Xiang

    2017-04-01

    Background: In cross-sectional studies and short-term clinical trials, it has been suggested that there is a positive dose-response relation between alcohol consumption and HDL concentrations. However, prospective data have been limited. Objective: We sought to determine the association between total alcohol intake, the type of alcohol-containing beverage, and the 6-y (2006-2012) longitudinal change in HDL-cholesterol concentrations in a community-based cohort. Design: A total of 71,379 Chinese adults (mean age: 50 y) who were free of cardiovascular diseases and cancer and did not use cholesterol-lowering agents during follow-up were included in the study. Alcohol intake was assessed via a questionnaire in 2006 (baseline), and participants were classified into the following categories of alcohol consumption: never, past, light (women: 0-0.4 servings/d; men: 0-0.9 servings/d), moderate (women: 0.5-1.0 servings/d; men: 1-2 servings/d), and heavy (women: >1.0 servings/d; men: >2 servings/d). HDL-cholesterol concentrations were measured in 2006, 2008, 2010, and 2012. We used generalized estimating equation models to examine the associations between baseline alcohol intake and the change in HDL-cholesterol concentrations with adjustment for age, sex, smoking, physical activity, obesity, hypertension, diabetes, liver function, and C-reactive protein concentrations. Results: An umbrella-shaped association was observed between total alcohol consumption and changes in HDL-cholesterol concentrations. Compared with never drinkers, past, light, moderate, and heavy drinkers experienced slower decreases in HDL cholesterol of 0.012 mmol · L -1 · y -1 (95% CI: 0.008, 0.016 mmol · L -1 · y -1 ), 0.013 mmol · L -1 · y -1 (95% CI: 0.010, 0.016 mmol · L -1 · y -1 ), 0.017 mmol · L -1 · y -1 (95% CI: 0.009, 0.025 mmol · L -1 · y -1 ), and 0.008 mmol · L -1 · y -1 (95% CI: 0.005, 0.011 mmol · L -1 · y -1 ), respectively ( P alcohol consumption was associated with the

  13. New insights into the determination of HDL structure by apolipoproteins1

    Science.gov (United States)

    Phillips, Michael C.

    2013-01-01

    Apolipoprotein (apo)A-I is the principal protein component of HDL, and because of its conformational adaptability, it can stabilize all HDL subclasses. The amphipathic α-helix is the structural motif that enables apoA-I to achieve this functionality. In the lipid-free state, the helical segments unfold and refold in seconds and are located in the N-terminal two thirds of the molecule where they are loosely packed as a dynamic, four-helix bundle. The C-terminal third of the protein forms an intrinsically disordered domain that mediates initial binding to phospholipid surfaces, which occurs with coupled α-helix formation. The lipid affinity of apoA-I confers detergent-like properties; it can solubilize vesicular phospholipids to create discoidal HDL particles with diameters of approximately 10 nm. Such particles contain a segment of phospholipid bilayer and are stabilized by two apoA-I molecules that are arranged in an anti-parallel, double-belt conformation around the edge of the disc, shielding the hydrophobic phospholipid acyl chains from exposure to water. The apoA-I molecules are in a highly dynamic state, and they stabilize discoidal particles of different sizes by certain segments forming loops that detach reversibly from the particle surface. The flexible apoA-I molecule adapts to the surface of spherical HDL particles by bending and forming a stabilizing trefoil scaffold structure. The above characteristics of apoA-I enable it to partner with ABCA1 in mediating efflux of cellular phospholipid and cholesterol and formation of a heterogeneous population of nascent HDL particles. Novel insights into the structure-function relationships of apoA-I should help reveal mechanisms by which HDL subclass distribution can be manipulated. PMID:23230082

  14. Pre-clinical evaluation of rHDL encapsulated retinoids for the treatment of Neuroblastoma

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    Nirupama eSabnis

    2013-03-01

    Full Text Available Despite major advances in pediatric cancer research, there has been only modest progress in the survival of children with high risk neuroblastoma (HRNB. The long term survival rates of HRNB in the United States are still only 30-50%. Due to resistance that often develops during therapy, development of new effective strategies is essential to improve the survival and overcome the tendency of HRNB patients to relapse subsequent to initial treatment. Current chemotherapy regimens also have a serious limitation due to off target toxicity. In the present work, we evaluated the potential application of reconstituted high density lipoprotein (rHDL containing fenretinide (FR nanoparticles as a novel approach to current neuroblastoma therapeutics. The characterization and stability studies of rHDL-FR nanoparticles showed small size (<40nm and high encapsulation efficiency. The cytotoxicity studies of free FR vs. rHDL/ FR towards the neuroblastoma cell lines SK-N-SH and SMS-KCNR showed 2.8 and 2 fold lower IC50 values for the rHDL encapsulated FR vs. free FR. More importantly, the IC50 value for retinal pigment epithelial cells (ARPE-19, a recipient of off target toxicity during FR therapy, was over 40 times higher for the rHDL/ FR as compared to that of free FR. The overall improvement in in vitro selective therapeutic efficiency was thus about 100 fold upon encapsulation of the drug into the rHDL nanoparticles. These studies support the potential value of this novel drug delivery platform for treating pediatric cancers in general, and neuroblastoma in particular

  15. [Lipoproteins HDL and coronary artery disease: a molecular mechanism of fibrate].

    Science.gov (United States)

    Kaletha, Krystian; Chodorowski, Zygmunt; Anand, Izabela Sein; Rybakowska, Iwona; Nagel-Starczynowska, Gabriela

    2003-01-01

    The importance of dyslipidemia in the development of cardiovascular disease is now recognized as a central factor of equal, if not greater significance than any other risk factor. Although correction of high level of low-density lipoproteins (LDL) has been regarded now as the main goal of therapy, it has now been reaffirmed that the contribution of low level of high-density lipoproteins (HDL) to the risk of ischaemic heart disease should also be considered. In the therapy of dislipidemias with hipertriglyceridemia and decreased level of HDL lipoprotein fibrates play an especially important role. In the article the molecular mechanism of fibrates action is presented.

  16. CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake.

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    Heidi J Silver

    Full Text Available Success in further reducing the burden of cardiovascular disease (CVD is threatened by the increasing prevalence of obesity-related atherogenic dyslipidemia. HDL-cholesterol (HDL-C level is inversely correlated with CVD risk; each 1 mg/dl decrease in HDL-C is associated with a 6% reduction in risk. We previously showed that a common CNR1 haplotype, H3 (frequency 20%, is protective against the reduction in HDL-C that typically accompanies weight gain. In the present study, we extend that observation by reporting the effect of CNR1 haplotype on HDL-C response to modification of dietary fat intake in weight maintenance and weight loss.Six haplotype tagging SNPs that cover the CNR1 gene locus were genotyped in 590 adults of varying body mass index (cohort 1 is 411 males with BMI 18.5-30.0 kg/m(2; cohort 2 is 71 females with BMI18.5-30.0 kg/m(2; and cohort 3 is 108 females with BMI 30-39.9 kg/m(2. Dietary intakes were modified so that fat intake in the "high fat" condition was 15-20% greater than in the "low fat" condition, and lipid profiles were compared between carriers versus noncarriers for each of the five commonly observed CNR1 haplotypes (H1-H5.In normal to overweight subjects on eucaloric diets, the H3 haplotype was significantly associated with short-term high fat diet induced changes in HDL-C level in females (carriers 5.9 mg/dl>noncarriers, p = 0.007. The H3 haplotype was also significantly associated with HDL-C level after 16 weeks on high fat calorie restricted diet in obese females (carriers 6.8 mg/dl>noncarriers, p = 0.009.Variability within the CNR1 gene locus contributes to gender-related differences in the HDL-cholesterol response to change in dietary fat intake. Functional characterization of this relationship in vitro may offer insights that potentially yield therapeutic guidance targeting dietary macronutrient composition, a direction much needed in the current epidemic of obesity.

  17. Alcohol-independent beneficial cardiometabolic profile of individuals with hyper-HDL cholesterolemia in Japanese men and women.

    Science.gov (United States)

    Wakabayashi, Ichiro; Daimon, Takashi

    2015-01-01

    There is limited information on characterization of individuals with hyper-high-density lipoprotein (HDL) cholesterolemia. The purpose of this study was to investigate the cardiometabolic profile of individuals with hyper-HDL cholesterolemia in comparison with the profile of individuals with normo-HDL cholesterolemia. The subjects were Japanese men and women who had hyper-HDL cholesterolemia (≥100 mg/dL) and their control subjects who had normal HDL cholesterol levels (≥40 and hyper- and normo-HDL cholesterolemic groups. Both in men and women, body mass index, waist-to-height ratio, triglycerides, low-density lipoprotein cholesterol, and hemoglobin A1c were significantly lower in subjects with hyper-HDL cholesterolemia than in subjects with normo-HDL cholesterolemia, whereas systolic and diastolic blood pressure levels were not significantly different between the 2 groups. In generalized estimating equation with adjustment for smoking and regular exercise, odds ratios of the hyper- vs normo-HDL cholesterolemic groups were significantly lower than the reference level of 1.00 for high body mass index, high waist-to-height ratio, hypertriglyceridemia, hyper-low-density lipoprotein cholesterolemia, high lipid accumulation product, and metabolic syndrome. The previously mentioned results were obtained both in age-matched analysis and in age- and alcohol intake-matched analysis, although the percentage of regular drinkers was significantly higher in the hyper-HDL cholesterolemic group than in the age-matched control group. Hyper-HDL cholesterolemia was inversely associated with obesity, dyslipidemia, and metabolic syndrome in the analysis using alcohol intake-matched subject groups. Therefore, the association of hyper-HDL cholesterolemia with lower cardiometabolic risk is thought to be independent of habitual alcohol drinking. Copyright © 2015 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  18. HDL acceptor capacities for cholesterol efflux from macrophages and lipid transfer are both acutely reduced after myocardial infarction.

    Science.gov (United States)

    Soares, Alexandre A S; Tavoni, Thauany M; de Faria, Eliane C; Remalay, Alan T; Maranhão, Raul C; Sposito, Andrei C

    2018-03-01

    The transport of lipids from the artery wall is one of the most essential anti-atherogenic functions of high-density lipoprotein (HDL). Recent reports of changes in the HDL composition, during myocardial infarction (MI), suggest that this function may be altered. Forty-one consecutive patients with ST-segment elevation MI enrolled at the Brasilia Heart Study were selected. The following HDL-related measures were determined upon admission (D1) and on the fifth day (D5) after MI: C-reactive protein, CETP and PLTP activity, HDL composition, efflux of cholesterol from J774 macrophages to HDL, and transfer of unesterified and esterified cholesterol, triglycerides and phospholipids from a donor nanoemulsion to HDL. From D1 to D5, the activity of CETP decreased by 25%, but PLTP activity remained unchanged. Esterified cholesterol (-23%) and phospholipid (-9.5%) contents of HDL decreased. Transfer of triglycerides (-36.5%) and esterified cholesterol (-14.7%) to HDL from nanoemulsions was reduced, but other lipids transfers were unchanged. Cholesterol efflux to HDL was also diminished by 8.5% (p=0.04) on D5 compared to D1. It was more pronounced in patients above the 75th percentile of C-reactive protein. After an MI, a simultaneous decrease in lipid transfer to HDL and in the capacity of HDL to efflux cholesterol from cells occurs. Thus, HDL with inferior atheroprotective properties may be generated in the acute post-MI period. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Correlações entre variáveis respiratórias e funcionais na insuficiência cardíaca

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    Fábio Cangeri Di Naso

    2009-09-01

    Full Text Available Resumo: Fundamento: Alterações respiratórias podem in-fluenciar o desempenho funcional em doentes com insuficiência cardíaca (IC.Objectivo: Correlacionar a força muscular inspiratória máxima (PImax e as variáveis da função pulmonar com a capacidade funcional em doentes com IC.Métodos: Estudo transversal realizado de Janeiro a Julho de 2007 incluindo 42 doentes com IC crónica (28 ho-mens que não apresentavam doença pulmonar prévia. Os doentes pertenciam às classes funcionais I, II e III segundo a NYHA (New York Heart Association. As variáveis respiratórias mensuradas foram a PImax, a CVF (capacidade vital forçada e o VEF1(volume expiratório forçado no 1.º segundo. A distância percorrida no teste da caminhada dos seis minutos (TC6M, a classe funcional (CF e o domínio referente à capacidade funcional do questionário de qualidade de vida Short Form-36 (SF-36 foram as variáveis funcionais utilizadas.Resultados: A PImax correlacionou-se com a TC6M (r=0,543 e p<0,001, com a CF (r=-0,566 e p<0,001 e com a pontuação do domínio capacidade funcional do SF-36 (r=0,459 e p=0,002. O mesmo ocorre com a CVF e as variáveis TC6M (r=0,501 e p=0,001, CF (r=-0,477 e p=0,001 e SF-36 (r=0,314 e p=0,043. O VEF1 apresentou correlação com a TC6M (r=0,514 e p<0,001 e com a CF (r=-0,383 e p=0,012.Conclusão: Variáveis respiratórias referentes à função pulmonar e à força muscular inspiratória correlacio-nam com variáveis funcionais em doentes com IC.Rev Port Pneumol 2009; XV (5: 875-890 Abstract: Background: Respiratory alterations can impact on the functional performance of patients with heart failure.Aim: To correlate maximum inspiratory muscular force and lung function variables with functional capacity in heart failure patients.Methods: A transversal study January-July 2007 with 42 chronic heart disease patients (28 males with no prior

  20. Nutrientes e propriedades funcionais em sementes de abóbora (Cucurbita maxima submetidas a diferentes processamentos Nutrients and functional properties in pumpkin seed (Cucurbita maxima submitted to different processings

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    Luciana de Paula Naves

    2010-05-01

    Full Text Available O objetivo deste trabalho foi verificar a influência dos processamentos térmicos sobre os nutrientes e propriedades funcionais das sementes da abóbora Cucurbita maxima. As sementes foram, em quatro repetições, submetidas aos seguintes processamentos: utilizadas na forma crua; cozidas em água em ebulição por três tempos: 5, 10 e 15 minutos; e cozidas no vapor por 10 minutos. Posteriormente foram liofilizadas, trituradas e armazenadas em temperatura ambiente até a realização das análises de composição centesimal, minerais e propriedades funcionais. Não houve diferença significativa entre os processamentos para os níveis de proteína bruta, fibra alimentar, extrato etéreo, cinzas, S, P, Mg, Ca, Cu, Zn, solubilidade do nitrogênio (nos pH 4, 5 e 6, absorção de água e óleo, volume de espuma e estabilidade de emulsão. O cozimento em água em ebulição reduziu o teor de K. Todos os processamentos térmicos diminuíram os níveis de Mn e Fe. As sementes cruas apresentaram a maior solubilidade do nitrogênio nos pH 2, 3, 7, 8 e 9. Conclui-se que os processamentos acarretaram diferença significativa apenas nos teores de K, Mn, Fe e solubilidade do nitrogênio; e que as sementes apresentam potencial para serem incorporadas, provavelmente, em alimentos que requeiram elevada taxa de absorção de óleo.The objective of this paper was to verify the influence of the thermal processings on the nutrients and functional properties of the pumpkin seeds Cucurbita maxima. Seeds were, in four repetitions, submitted to the following processings: used in the raw form; cooked in boiling water for three times: 5, 10 and 15 minutes; and cooked in steam for 10 minutes. Thereafter were freeze-dried, grinded and stored at room temperature up to accomplishment of the analyses of centesimal composition, minerals and functional properties. There wasn't significant difference among the processings to the levels of crude protein, dietary fiber, ether

  1. HUBUNGAN ANTARA AKTIVITAS FISIK DAN ANGKA KECUKUPAN GIZI MAKRONUTRIEN TERHADAP RASIO KOLESTEROL TOTAL/HDL PADA MASYARAKAT PEDESAAN

    Directory of Open Access Journals (Sweden)

    Utari Febrina Supomo Sunu

    2017-05-01

    Full Text Available Cardiovascular disease is the number one cause of death in the world. The diseaseis influenced by several factors such as lack of physical activity, imbalanced nutritional intake, and high blood cholesterol levels. The value of the total cholesterol / HDL can predict cardiovascular disease risk factors.  The study aims to investigate the relationship between physical activity and Dietary Allowances of the macronutrient and ratio total cholesterol / HDL in rural communities. This is observational analytic with cross-sectional design of the 102 respondents (male: 40, female: 62 in Kepuharjo village, Cangkringan, Sleman, Yogyakarta, with a purposive sampling techniques. Physical activity data were taken using a structured interview (Baecke and Semi Quantitive Food Frequency Questionnaire (SQFFQ for data macronutrient, while blood total cholesterol and HDL-cholesterol levels  were analyzed using enzymatic methods. The results of the study showed that there is no significant relationship between physical activity and the ratio of total cholesterol / HDL (p = 0.038; CI 95%: 0.98-61.33, dietary allowances of the macronutrient energy and the ratio of total cholesterol / HDL (p = 0.068, protein intake on the ratio of total cholesterol / HDL (p = 1.000, fat intake to the ratio of total cholesterol / HDL (p = 0.081, and the intake of carbohydrates to the ratio of total cholesterol / HDL (p = 0.088. In conclusion  there is no significant relationship between physical activity and dietary allowance of macronutrient towards to the ratio of total cholesterol / HDL.

  2. Aspectos clínicos e funcionais do equilíbrio corporal em idosos com vertigem posicional paroxística benigna Clinical and functional aspects of body balance in elderly subjects with benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    Daniela Patricia Vaz

    2013-04-01

    Full Text Available Vertigem Posicional Paroxística Benigna (VPPB pode alterar o equilíbrio corporal em pacientes idosos. OBJETIVO: Observar os efeitos da manobra de Epley em idosos com VPPB, avaliando os aspectos clínicos e funcionais do equilíbrio corporal. Forma de estudo: clínico e prospectivo. MÉTODO: Após o diagnóstico da doença (teste de DixHallpike, os testes Time Up and Go (TUGT, Clinical test of Sensory Interaction and Balance (CTSIB e o teste de membros inferiores (MMI foram realizados antes e após a manobra de reposicionamento de Epley modificada. RESULTADOS: O gênero feminino foi o mais prevalente e a média etária foi de 70,10 anos (DP = 7,00. Todos os pacientes apresentaram ductolitíase de canal posterior. Os seguintes sintomas melhoraram após a manobra: a instabilidade postural (p = 0,006, náusea e vômito (p = 0,021 e zumbido (p = 0,003. Em relação ao TUGT e o escore do teste de MMII, observou-se diminuição significante do tempo pós-manobra de Epley (p Benign paroxysmal positional vertigo (BPPV may compromise the balance of elderly subjects. OBJECTIVE: To observe the effects of the Epley maneuver in elderly subjects with BPPV and assess clinical and functional aspects of body balance. METHOD: This is a prospective clinical study. Patients diagnosed with BPPV (Dix-Hallpike test were submitted to the Timed Up & Go (TUG test, the Clinical Test of Sensory Interaction and Balance (CTSIB, and lower limb testing before and after they were repositioned using the modified Epley maneuver. RESULTS: Most subjects were females, and the group's mean age was 70.10 years (SD = 7.00. All patients had canalithiasis of the posterior canal. The following symptoms improved after the maneuver: postural instability (p = 0.006, nausea and vomiting (p = 0.021, and tinnitus (p = 0.003. Subjects improved their times significantly in the TUG and lower limb tests after the Epley maneuver (p < 0.001. Patients performed better on the CTSIB after the Epley

  3. Proteinuria increases oxylipid concentrations in VLDL and HDL but not LDL particles in the rat.

    Science.gov (United States)

    Newman, John W; Kaysen, George A; Hammock, Bruce D; Shearer, Gregory C

    2007-08-01

    We previously established that proteinuria alters the apolipoprotein content of lipoproteins. This study was conducted to establish whether proteinuria also alters the concentrations of oxidized lipids within lipoprotein density fractions. To this end, we induced passive Heymann nephritis in Sprague Dawley rats and measured an array of alkaline-stable oxylipids in VLDL, LDL, and HDL particles. Proteinuria increased the total oxylipid amounts in the HDL and VLDL fractions. More importantly, these levels were increased when expressed per unit lipoprotein protein, indicating that the oxidized lipid load per particle was increased. Epoxides and diols increased approximately 2-fold in HDL and approximately 5-fold in VLDL, whereas LDL showed approximately 2-fold decreases. The hydroxyeicosatetraenoic acids and hydroxyoctadecadienoic acids (HODEs) increased >4-fold in HDL and >20-fold in VLDL, whereas LDL showed approximately 2-fold decreases in the HODEs. Therefore, nephrotic syndrome alters the lipoprotein oxylipid composition independently of an increase in total lipoprotein levels. These proteinuria-induced changes may be associated with the cardiovascular risk of lipoprotein oxidation.

  4. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events

    NARCIS (Netherlands)

    Barter, Philip; Gotto, Antonio M.; LaRosa, John C.; Maroni, Jaman; Szarek, Michael; Grundy, Scott M.; Kastelein, John J. P.; Bittner, Vera; Fruchart, Jean-Charles

    2007-01-01

    BACKGROUND: High-density lipoprotein (HDL) cholesterol levels are a strong inverse predictor of cardiovascular events. However, it is not clear whether this association is maintained at very low levels of low-density lipoprotein (LDL) cholesterol. METHODS: A post hoc analysis of the recently

  5. Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population

    DEFF Research Database (Denmark)

    Frikke-Schmidt, Ruth; Nordestgaard, Børge G; Jensen, Gorm B

    2004-01-01

    and some with consistent trends in men, determined as isolated single-site effects varying only at the relevant SNP. Finally, these results were consistent over time. In conclusion, we show that at least 10% of individuals with low HDL-C in the general population are heterozygous for mutations in ABCA1...

  6. Effect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial.

    Science.gov (United States)

    Neufingerl, Nicole; Zebregs, Yvonne E M P; Schuring, Ewoud A H; Trautwein, Elke A

    2013-06-01

    Evidence from clinical studies has suggested that cocoa may increase high-density lipoprotein (HDL)-cholesterol concentrations. However, it is unclear whether this effect is attributable to flavonoids or theobromine, both of which are major cocoa components. We investigated whether pure theobromine increases serum HDL cholesterol and whether there is an interaction effect between theobromine and cocoa. The study had a 2-center, double-blind, randomized, placebo-controlled, full factorial parallel design. After a 2-wk run-in period, 152 healthy men and women (aged 40-70 y) were randomly allocated to consume one 200-mL drink/d for 4 wk that contained 1) cocoa, which naturally provided 150 mg theobromine and 325 mg flavonoids [cocoa intervention (CC)], 2) 850 mg pure theobromine [theobromine intervention (TB)], 3) cocoa and added theobromine, which provided 1000 mg theobromine and 325 mg flavonoids [theobromine and cocoa intervention (TB+CC)], or 4) neither cocoa nor theobromine (placebo). Blood lipids and apolipoproteins were measured at the start and end of interventions. In a 2-factor analysis, there was a significant main effect of the TB (P Theobromine independently increased serum HDL-cholesterol concentrations by 0.16 mmol/L. The lack of significant cocoa and interaction effects suggested that theobromine may be the main ingredient responsible for the HDL cholesterol-raising effect. This trial was registered at clinicaltrials.gov as NCT01481389.

  7. HDL does not influence the polarization of human monocytes toward an alternative phenotype

    NARCIS (Netherlands)

    Colin, Sophie; Fanchon, Mélanie; Belloy, Loic; Bochem, Andrea E.; Copin, Corinne; Derudas, Bruno; Stroes, Erik S. G.; Hovingh, G. Kees; Kuivenhoven, Jan A.; Dallinga-Thie, Geesje M.; Staels, Bart; Chinetti-Gbaguidi, Giulia

    2014-01-01

    Macrophages are crucial cells in the pathogenesis of atherosclerosis. Macrophages are plastic cells which can switch from a classical pro-inflammatory M1 to an alternative anti-inflammatory M2 macrophage phenotype, depending on the environmental stimuli. Because high-density lipoprotein (HDL)

  8. Blood-borne LPS is rapidly eliminated by liver sinusoidal endothelial cells via HDL

    Science.gov (United States)

    Yao, Zhili; Mates, Jessica M.; Cheplowitz, Alana M.; Hammer, Lindsay P.; Maiseyeu, Andrei; Phillips, Gary S.; Wewers, Mark D.; Rajaram, Murugesan V.S.; Robinson, John M.; Anderson, Clark L.; Ganesan, Latha P.

    2016-01-01

    During Gram-negative bacterial infections, excessive lipopolysaccharide (LPS) induces inflammation and sepsis via action on immune cells. However, the bulk of LPS can be cleared from circulation by the liver. Liver clearance is thought to be a slow process mediated exclusively by phagocytic resident macrophages, Kupffer cells (KC). However, we discovered that LPS disappears rapidly from the circulation, with a half-life of 2–4 minutes in mice and liver eliminates about three quarters of LPS from blood circulation. Using microscopic techniques, we found that ~75% of fluor-tagged LPS in liver became associated with liver sinusoidal endothelial cells (LSEC) and only ~25% with KC. Notably, the ratio of LSEC-KC associated LPS remained unchanged 45 min after infusion, indicating that LSEC independently processes the LPS. Most interestingly, results of kinetic analysis of LPS bioactivity, using modified limulus amebocyte lysate assay, suggest that recombinant factor-C, an LPS binding protein, competitively inhibits HDL-mediated LPS association with LSEC early in the process. Supporting the previous notion 3 min post-infusion, 75% of infused fluorescently-tagged LPS-HDL complex associates with LSEC, suggesting that HDL facilitates LPS clearance. These results lead us to propose a new paradigm of LSEC and HDL in clearing LPS with a potential to avoid inflammation during sepsis. PMID:27534554

  9. Structure of spheroidal HDL particles revealed by combined atomistic and coarse-grained simulations

    NARCIS (Netherlands)

    Catte, Andrea; Patterson, James C.; Bashtovyy, Denys; Jones, Martin K.; Gu, Feifei; Li, Ling; Rampioni, Aldo; Sengupta, Durba; Vuorela, Timo; Niemela, Perttu; Karttunen, Mikko; Marrink, Siewert Jan; Vattulainen, Ilpo; Segrest, Jere P.

    2008-01-01

    Spheroidal high-density lipoprotein (HDL) particles circulating in the blood are formed through an enzymatic process activated by apoA-1, leading to the esterification of cholesterol, which creates a hydrophobic core of cholesteryl ester molecules in the middle of the discoidal phospholipid bilayer.

  10. Plasma HDL cholesterol and risk of myocardial infarction : A mendelian randomisation study

    NARCIS (Netherlands)

    Voight, Benjamin F.; Peloso, Gina M.; Orho-Melander, Marju; Frikke-Schmidt, Ruth; Barbalic, Maja; Jensen, Majken K.; Hindy, George; Holm, Hilma; Ding, Eric L.; Johnson, Toby; Schunkert, Heribert; Samani, Nilesh J.; Clarke, Robert; Hopewell, Jemma C.; Thompson, John F.; Li, Mingyao; Thorleifsson, Gudmar; Newton-Cheh, Christopher; Musunuru, Kiran; Pirruccello, James P.; Saleheen, Danish; Chen, Li; Stewart, Alexandre F. R.; Schillert, Arne; Thorsteinsdottir, Unnur; Thorgeirsson, Gudmundur; Anand, Sonia; Engert, James C.; Morgan, Thomas; Spertus, John; Stoll, Monika; Berger, Klaus; Martinelli, Nicola; Girelli, Domenico; McKeown, Pascal P.; Patterson, Christopher C.; Epstein, Stephen E.; Devaney, Joseph; Burnett, Mary-Susan; Mooser, Vincent; Ripatti, Samuli; Surakka, Ida; Nieminen, Markku S.; Sinisalo, Juha; Lokki, Marja-Liisa; Perola, Markus; Havulinna, Aki; de Faire, Ulf; Gigante, Bruna; Ingelsson, Erik; Zeller, Tanja; Wild, Philipp; de Bakker, Paul I. W.; Klungel, Olaf H.; Maitland-van der Zee, Anke-Hilse; Peters, Bas J. M.; de Boer, Anthonius; Grobbee, Diederick E.; Kamphuisen, Pieter W.; Deneer, Vera H. M.; Elbers, Clara C.; Onland-Moret, N. Charlotte; Hofker, Marten H.; Wijmenga, Cisca; Verschuren, W. M. Monique; Boer, Jolanda M. A.; van der Schouw, Yvonne T.; Rasheed, Asif; Frossard, Philippe; Demissie, Serkalem; Willer, Cristen; Do, Ron; Ordovas, Jose M.; Abecasis, Goncalo R.; Boehnke, Michael; Mohlke, Karen L.; Daly, Mark J.; Guiducci, Candace; Burtt, Noel P.; Surti, Aarti; Gonzalez, Elena; Purcell, Shaun; Gabriel, Stacey; Marrugat, Jaume; Peden, John; Erdmann, Jeanette; Diemert, Patrick; Willenborg, Christina; Koenig, Inke R.; Fischer, Marcus; Hengstenberg, Christian; Ziegler, Andreas; Buysschaert, Ian; Lambrechts, Diether; Van de Werf, Frans; Fox, Keith A.; El Mokhtari, Nour Eddine; Rubin, Diana; Schrezenmeir, Juergen; Schreiber, Stefan; Schaefer, Arne; Danesh, John; Blankenberg, Stefan; Roberts, Robert; McPherson, Ruth; Watkins, Hugh; Hall, Alistair S.; Overvad, Kim; Rimm, Eric; Boerwinkle, Eric; Tybjaerg-Hansen, Anne; Cupples, L. Adrienne; Reilly, Muredach P.; Melander, Olle; Mannucci, Pier M.; Ardissino, Diego; Siscovick, David; Elosua, Roberto; Stefansson, Kari; O'Donnell, Christopher J.; Salomaa, Veikko; Rader, Daniel J.; Peltonen, Leena; Schwartz, Stephen M.; Altshuler, David; Kathiresan, Sekar

    2012-01-01

    Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease

  11. HUBUNGAN ASUPAN ENERGI, LEMAK DAN SERAT DENGAN RASIO KADAR KOLESTEROL TOTAL-HDL

    Directory of Open Access Journals (Sweden)

    Emy Yuliantini

    2016-09-01

    Full Text Available Perubahan pola hidup menyebabkan pola penyakit berubah, dari penyakit infeksi dan rawan gizi ke penyakit-penyakit  degeneratif, diantaranya adalah penyakit jantung dan pembuluh darah (kardiovaskuler dan akibat kematian yang ditimbulkannya. Penyakit jantung merupakan penyebab kematian nomor satu di dunia. Penyakit jantung adalah penyakit yang mengganggu sistem pembuluh darah atau lebih tepatnya menyerang jantung dan urat-urat darah. Penyakit kardiovaskuler (PKV mempunyai hubungan yang erat dengan zat gizi dan makanan. Hipotesis “makanan-jantung“ atau diet-heart hypothesis menerangkan bahwa adanya hubungan antara makanan dengan penyakit jantung. Tujuan penelitian ini untuk mengetahui faktor-faktor yang berhubungan dengan rasio kadar kolesterol total/HDL. Desain penelitian ini adalah potong lintang/cross sectional dengan variabel independen (asupan energi, asupan lemak jenuh, lemak tak jenuh, kolesterol dan serat dan variabel dependen (rasio kadar kolesterol total/HDL. Jumlah populasi 760 dan sampel sebanyak 45 responden. Sampel penelitian diambil secara accidental sampling. Hasil penelitian menunjukkan bahwa ada hubungan yang bermakna antara asupan energi, lemak jenuh, lemak tak jenuh dan kolesterol dengan rasio kadar kolesterol total/HDL. Tidak ada hubungan yang bermakna antar asupan serat dengan rasio kadar kolesterol total/HDL. Faktor yang paling berhubungan adalah asupan lemak jenuh.

  12. Kinetics of HDL cholesterol and paraoxonase activity in moderate alcohol consumers

    NARCIS (Netherlands)

    Sierksma, A.; Gaag, M.S. van der; Tol, A. van; James, R.W.; Hendriks, H.F.J.

    2002-01-01

    Background: The inverse association between moderate drinking and coronary heart disease mortality is well established. This study was performed to investigate the kinetics of the alcohol-induced increases in apo A-1, HDL cholesterol, and paraoxonase (PON) activity, as well as to study whether the

  13. Hardware Reuse Improvement through the Domain Specific Language dHDL.

    OpenAIRE

    Sánchez Marcos, Miguel Ángel; López Vallejo, Marisa; Iglesias Fernandez, Carlos Angel

    2012-01-01

    The dHDL language has been defined to improve hardware design productivity. This is achieved through the definition of a better reuse interface (including parameters, attributes and macroports) and the creation of control structures that help the designer in the hardware generation process.

  14. Clinical and biological relevance of statin-mediated changes in HDL metabolism

    NARCIS (Netherlands)

    Arsenault, Benoit J.; Boekholdt, S. Matthijs

    2014-01-01

    Although prospective studies consistently show that individuals with low levels of high-density lipoprotein (HDL) cholesterol are at increased cardiovascular risk, it is still not clear whether or not this relationship still holds in patients treated with statins who have achieved optimal

  15. Egg intake improves carotenoid status by increasing plasma HDL cholesterol in adults with metabolic syndrome.

    Science.gov (United States)

    Blesso, Christopher N; Andersen, Catherine J; Bolling, Bradley W; Fernandez, Maria Luz

    2013-02-01

    Metabolic syndrome (MetS) is associated with reductions in plasma lutein and zeaxanthin, along with altered composition of their lipoprotein transporters which may affect disease risk. Egg yolk intake has been demonstrated to increase plasma lutein and zeaxanthin in other populations. The objective of this study was to investigate the effects of whole egg feeding on plasma and lipoprotein carotenoids in participants with MetS. Participants consumed 3 whole eggs per day (EGG, n = 20) or the equivalent amount of yolk-free egg substitute (SUB, n = 17), as part of a carbohydrate-restricted diet (CRD) for 12 weeks. Post-intervention, the EGG group had significant increases in plasma lutein (+21%), zeaxanthin (+48%), and β-carotene (+24%), while the SUB group had increases in plasma β-carotene (+55%) only. Significant enrichment of isolated HDL and LDL fractions in lutein (+20% HDL, +9% LDL) and zeaxanthin (+57% HDL, +46% LDL) was observed in the EGG group after 12 weeks. Increases in the proportion of plasma carotenoids carried by HDL was seen for lutein (P eggs, as part of a CRD, increased both plasma and lipoprotein lutein and zeaxanthin. Egg yolk may represent an important food source to improve plasma carotenoid status in a population at high risk for cardiovascular disease and type 2 diabetes.

  16. Human paraoxonase and HDL-cholesterol in pakistan patients with acute myocardial infarction and normal healthy adults

    International Nuclear Information System (INIS)

    Iqbal, I.P.; Khan, A.H.; Mehboobali, N.

    2007-01-01

    Human serum paraoxonase is a high density lipoprotein (HDL)-bound enzyme exhibiting antiatherogenic properties. The aim of this study was to investigate any relationship between serum paraoxonase activity and serum levels of HDL-cholesterol in Pakistani patients with acute myocardial infarction (AMI) compared to normal healthy subjects and to examine possible association between serum paraoxonase activity and AMI in Pakistani population. In a case-control study, serum paraoxonase activity and serum levels of HDL-cholesterol and LDL-cholesterol were monitored in 164 Pakistani patients with AMI and 106 normal healthy adults matched for gender, BMI and age within 10 years. Mean serum concentration of HDL-cholesterol and mean serum paraoxonase activity in AMI patients were not significantly different from the corresponding values in normal healthy subjects. Mean serum paraoxonase activity value was significantly lower in normal healthy subjects with low HDL-cholesterol (serum levels < 40mg/dl) compared to the value in those with normal levels of HDL-cholesterol (P=0.04). In AMI patients, paraoxonase activity was lower in subjects with low HDL-cholesterol compared to those with normal levels of HDL-cholesterol, however, the decrease was not statistically significant. Correlation analyses of the data revealed a moderate association of paraoxonase activity with HDL-cholesterol (Pearson's r= 0.225, P<0.01 for AMI patients and r=0.281, P<0.01 for normal healthy controls). Seventy three percent of normal healthy subjects and 65% of AMI patients in this study had low HDL-cholesterol. Low serum paraoxonase activity and high prevalence of low HDL-cholesterol in Pakistani population could be contributing to the high rates of coronary heart disease in this population. (author)

  17. A IMPORTÂNCIA DA MOBILIZAÇÃO PRECOCE EM PACIENTES INTERNADOS NA UNIDADE DE TERAPIA INTENSIVA (UTI): REVISÃO DE LITERATURA

    OpenAIRE

    Salvador José de Castro Júnior

    2013-01-01

    O imobilismo, característico nos pacientes críticos das unidades de terapia intensiva (UTIs) acomete diversos órgãos e sistemas do organismo, ocasionando um prolongamento da internação e limitações funcionais que repercutem por algum tempo após a alta hospitalar, afetando a qualidade de vida e a reintegração do indivíduo a sociedade. A fisioterapia se faz importante nesse momento crítico através da intervenção precoce que auxilia na redução dos efeitos adversos da imobilidade. O o...

  18. Oxidative profiles of LDL and HDL isolated from women with preeclampsia.

    Science.gov (United States)

    León-Reyes, G; Maida-Claros, R F; Urrutia-Medina, A X; Jorge-Galarza, E; Guzmán-Grenfell, A M; Fuentes-García, S; Medina-Navarro, R; Moreno-Eutimio, M A; Muñoz-Sánchez, J L; Hicks, J J; Torres-Ramos, Y D

    2017-05-16

    Oxidative stress causes biochemical changes in lipids and proteins; these changes can induce damage to the vascular endothelium and create maternal complications that are characteristic of preeclampsia. In this study, we evaluated the oxidative profile of lipoproteins isolated from women with preeclampsia. Thirty women diagnosed with preeclampsia and thirty women without preeclampsia were included in the study. Lipid-damage biomarkers, including conjugated dienes, lipohydroperoxides and malondialdehyde, were measured. The reduction of nitroblue tetrazolium, the formation of dityrosines, and the carbonylation of proteins were assessed as indicators of protein damage. The protective activity of HDL-c was evaluated by the paraoxonase-I activity present on the HDL-c particles. Serum lipid profiles were also quantified in both groups. Data were analysed using Student's t test and the Pearson correlation coefficient. Our results demonstrated in PE women evident oxidative changes in the lipids and proteins in HDL-c and LDL-c particles and the activity of the antioxidant enzyme PON-I decreased 59.9%. HDL-c exhibited self-defence, as demonstrated by the negative correlation between paraoxonase-I activity and the formation of lipohydroperoxides in HDL-c (r = -0.3755, p preeclampsia show oxidative damage to lipids and proteins. We propose an oxidative profile based on the oxidation levels indicated by each of the markers used. We also found that paraoxonase-I is inactivated in the presence of lipohydroperoxides. Antioxidant support might be helpful to reduce oxidative stress in patients with preeclampsia. Further investigations are necessary to define the association between antioxidant activities and preeclampsia.

  19. Postpartum weight retention is associated with elevated ratio of oxidized LDL lipids to HDL-cholesterol.

    Science.gov (United States)

    Puhkala, Jatta; Luoto, Riitta; Ahotupa, Markku; Raitanen, Jani; Vasankari, Tommi

    2013-12-01

    Oxidized LDL lipids (ox-LDL) are associated with lifestyle diseases such as cardiovascular diseases, metabolic syndrome and type 2 diabetes. The present study investigated how postpartum weight retention effects on ox-LDL and serum lipids. The study is a nested comparative research of a cluster-randomized controlled trial, NELLI (lifestyle and counselling during pregnancy). During early pregnancy (8-12 weeks) and 1 year postpartum, 141 women participated in measurements for determining of plasma lipids: total cholesterol (T-C), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triacylglycerols (TAG) and ox-LDL. Subjects were stratified into tertiles (weight loss, unaltered weight and weight gain groups) based on their weight change from baseline to follow-up. Ox-LDL was determined by baseline level of conjugated dienes in LDL lipids. Among the group of weight gainers, concentration of TAG reduced less (-0.14 vs. -0.33, p = 0.002), HDL-C reduced more (-0.31 vs. -0.16, p = 0.003) and ox-LDL/HDL-C ratio increased (3.0 vs. -0.2, p = 0.003) when compared to group of weight loss. Both T-C and LDL-C elevated more (0.14 vs. -0.21, p = 0.008; 0.31 vs. 0.07, p = 0.015) and TAG and ox-LDL reduced less (-0.33 vs. 0.20, p = 0.033; -3.33 vs. -0.68, p = 0.026) in unaltered weight group compared to weight loss group. The women who gained weight developed higher TAG and ox-LDL/HDL-C ratio as compared to those who lost weight. Postpartum weight retention of 3.4 kg or more is associated with atherogenic lipid profile.

  20. Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR study.

    Directory of Open Access Journals (Sweden)

    Caitrin W McDonough

    Full Text Available We sought to identify novel pharmacogenomic markers for HDL-C response to atenolol in participants with mild to moderate hypertension. We genotyped 768 hypertensive participants from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR study on the Illumina HumanCVD Beadchip. During PEAR, participants were randomized to receive atenolol or hydrochlorothiazide. Blood pressure and cholesterol levels were evaluated at baseline and after treatment. This study focused on participants treated with atenolol monotherapy. Association with atenolol induced HDL-C change was evaluated in 232 whites and 152 African Americans using linear regression. No SNPs achieved a Bonferroni corrected P-value. However, we identified 13 regions with consistent association across whites and African Americans. The most interesting of these regions were seven with prior associations with HDL-C, other metabolic traits, or functional implications in the lipid pathway: GALNT2, FTO, ABCB1, LRP5, STARD3NL, ESR1, and LIPC. Examples are rs2144300 in GALNT2 in whites (P=2.29x10(-4, β=-1.85 mg/dL and rs12595985 in FTO in African Americans (P=2.90x10(-4, β=4.52 mg/dL, both with consistent regional association (P<0.05 in the other race group. Additionally, baseline GALNT2 expression differed by rs2144300 genotype in whites (P=0.0279. In conclusion, we identified multiple gene regions associated with atenolol induced HDL-C change that were consistent across race groups, several with functional implications or prior associations with HDL-C.

  1. Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels

    Directory of Open Access Journals (Sweden)

    Hinds David A

    2004-11-01

    Full Text Available Abstract Association studies are used to identify genetic determinants of complex human traits of medical interest. With the large number of validated single nucleotide polymorphisms (SNPs currently available, two limiting factors in association studies are genotyping capability and costs. Pooled DNA genotyping has been proposed as an efficient means of screening SNPs for allele frequency differences in case-control studies and for prioritising them for subsequent individual genotyping analysis. Here, we apply quantitative pooled genotyping followed by individual genotyping and replication to identify associations with human serum high-density lipoprotein (HDL cholesterol levels. The DNA from individuals with low and high HDL cholesterol levels was pooled separately, each pool was amplified by polymerase chain reaction in triplicate and each amplified product was separately hybridised to a high-density oligonucleotide array. Allele frequency differences between case and control groups with low and high HDL cholesterol levels were estimated for 7,283 SNPs distributed across 71 candidate gene regions spanning a total of 17.1 megabases. A novel method was developed to take advantage of independently derived haplotype map information to improve the pooled estimates of allele frequency differences. A subset of SNPs with the largest estimated allele frequency differences between low and high HDL cholesterol groups was chosen for individual genotyping in the study population, as well as in a separate replication population. Four SNPs in a single haplotype block within the cholesteryl ester transfer protein (CETP gene interval were significantly associated with HDL cholesterol levels in both populations. Our study is among the first to demonstrate the application of pooled genotyping followed by confirmation with individual genotyping to identify genetic determinants of a complex trait.

  2. Increased inflammatory effect of electronegative LDL and decreased protection by HDL in type 2 diabetic patients.

    Science.gov (United States)

    Estruch, Montserrat; Miñambres, Inka; Sanchez-Quesada, Jose Luis; Soler, Marta; Pérez, Antonio; Ordoñez-Llanos, Jordi; Benitez, Sonia

    2017-10-01

    Type 2 diabetic patients have an increased proportion of electronegative low-density lipoprotein (LDL(-)), an inflammatory LDL subfraction present in blood, and dysfunctional high-density lipoprotein (HDL). We aimed at examining the inflammatory effect of LDL(-) on monocytes and the counteracting effect of HDL in the context of type 2 diabetes. This was a cross-sectional study in which the population comprised 3 groups (n = 12 in each group): type 2 diabetic patients with good glycaemic control (GC-T2DM patients), type 2 diabetic patients with poor glycaemic control (PC-T2DM), and a control group. Total LDL, HDL, and monocytes were isolated from plasma of these subjects. LDL(-) was isolated from total LDL by anion-exchange chromatography. LDL(-) from the three groups of subjects was added to monocytes in the presence or absence of HDL, and cytokines released by monocytes were quantified by ELISA. LDL(-) proportion and plasma inflammatory markers were increased in PC-T2DM patients. LDL(-) from PC-T2DM patients induced the highest IL1β, IL6, and IL10 release in monocytes compared to LDL(-) from GC-T2DM and healthy subjects, and presented the highest content of non-esterified fatty acids (NEFA). In turn, HDL from PC-T2DM patients showed the lowest ability to inhibit LDL(-)-induced cytokine release in parallel to an impaired ability to decrease NEFA content in LDL(-). Our findings show an imbalance in the pro- and anti-inflammatory effects of lipoproteins from T2DM patients, particularly in PC-T2DM. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase

    NARCIS (Netherlands)

    Simic, B.; Mocharla, P.; Crucet, M.; Osto, E.; Kratzer, A.; Stivala, S.; Kühnast, S.; Speet, T.; Doycheva, P.; Princen, H.M.G.; Hoorn, J.W.A. van der; Jukema, J.W.; Giral, H.; Tailleux, A.; Landmesser, U.; Syaels, B.; Lüscher, T.F.

    2017-01-01

    Background and aims. High-density lipoprotein cholesterol (HDL-C) is inversely related to cardiovascular risk. HDL-C raising ester transfer protein (CETP) inhibitors, are novel therapeutics. We studied the effects of CETP inhibitors anacetrapib and evacetrapib on triglycerides, cholesterol and

  4. Nonlinear dynamics of early atherosclerotic plaque formation may determine the efficacy of high density lipoproteins (HDL in plaque regression.

    Directory of Open Access Journals (Sweden)

    Alexander D Chalmers

    Full Text Available We use a computational model to explore the effect of foam cell accumulation on plaque regression following an increase in high density lipoprotein (HDL influx into the plaque. Atherosclerotic plaque formation is the outcome of cellular and cytokine responses to low density lipoproteins (LDL that penetrate the artery wall following an injury to the endothelium and become modified. We modelled the cells and cytokines that are most important in plaque formation using partial differential equations. The model includes monocytes and macrophages, foam cells, macrophage chemoattractants, endothelium-stimulating cytokines, modified low density lipoproteins (mod LDL and HDL. We included interactions both at the endothelium surface and inside the artery wall. The model predicts that when HDL influx into a well-established plaque with large numbers of foam cells is increased, the plaque may not regress but may continue to grow at a slower rate. If HDL influx is increased when a model plaque is recently established and has fewer foam cells, then the plaque does regress. If modLDL influx into the plaque is lowered at the same time that HDL influx increased or the capacity of the HDL to remove cholesterol from foam cells is increased, then the plaque is more likely to regress. The predictions of the model are in qualitative agreement with experimental studies in mice and rabbits. The results suggest that the intrinsic dynamics of reverse cholesterol transport by HDL are important in determining the success of HDL raising in promoting plaque regression.

  5. Native High Density Lipoproteins (HDL Interfere with Platelet Activation Induced by Oxidized Low Density Lipoproteins (OxLDL

    Directory of Open Access Journals (Sweden)

    Ivo Volf

    2013-05-01

    Full Text Available Platelets and lipoproteins play a crucial role in atherogenesis, in part by their ability to modulate inflammation and oxidative stress. While oxidized low density lipoproteins (OxLDL play a central role in the development of this disease, high density lipoproteins (HDL represent an atheroprotective factor of utmost importance. As platelet function is remarkably sensitive to the influence of plasma lipoproteins, it was the aim of this study to clarify if HDL are able to counteract the stimulating effects of OxLDL with special emphasis on aspects of platelet function that are relevant to inflammation. Therefore, HDL were tested for their ability to interfere with pro-thrombotic and pro-inflammatory aspects of platelet function. We are able to show that HDL significantly impaired OxLDL-induced platelet aggregation and adhesion. In gel-filtered platelets, HDL decreased both the formation of reactive oxygen species and CD40L expression. Furthermore, HDL strongly interfered with OxLDL-induced formation of platelet-neutrophil aggregates in whole blood, suggesting that platelets represent a relevant and sensitive target for HDL. The finding that HDL effectively competed with the binding of OxLDL to the platelet surface might contribute to their atheroprotective and antithrombotic properties.

  6. Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    Haan, W. de; Hoogt, C.C. van der; Westerterp, M.; Hoekstra, M.; Dallinga-Thie, G.M.; Princen, H.M.G.; Romijn, J.A.; Jukema, J.W.; Havekes, L.M.; Rensen, P.C.N.

    2008-01-01

    Objective: In addition to lowering low-density lipoprotein (LDL)-cholesterol, statins modestly increase high-density lipoprotein (HDL)-cholesterol in humans and decrease cholesteryl ester transfer protein (CETP) mass and activity. Our aim was to determine whether the increase in HDL depends on CETP

  7. Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    de Haan, Willeke; van der Hoogt, Caroline C.; Westerterp, Marit; Hoekstra, Menno; Dallinga-Thie, Geesje M.; Princen, Hans M. G.; Romijn, Johannes A.; Jukema, J. Wouter; Havekes, Louis M.; Rensen, Patrick C. N.

    2008-01-01

    OBJECTIVE: In addition to lowering low-density lipoprotein (LDL)-cholesterol, statins modestly increase high-density lipoprotein (HDL)-cholesterol in humans and decrease cholesteryl ester transfer protein (CETP) mass and activity. Our aim was to determine whether the increase in HDL depends on CETP

  8. Mistura betuminosa drenante em vias urbanas: desempenho e manutenção: Alameda da Europa, Covilhã

    OpenAIRE

    Tavares, Ana Isabel Ferreira

    2013-01-01

    Com o crescimento da urbanização e o consequente aumento da impermeabilidade do solo em áreas urbanas, há a necessidade de repensar os pavimentos utilizados em infraestruturas urbanas, incluindo ruas e passeios, a fim de garantir as suas características funcionais. Com as mudanças climáticas, há grandes picos de fluxos de águas pluviais em curtos períodos de tempo, devido às chuvas que afetam o desempenho dos pavimentos convencionais. Este facto dificulta o tráfego e promove situações de inun...

  9. Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes

    DEFF Research Database (Denmark)

    Siebel, Andrew L; Trinh, Si Khiang; Formosa, Melissa F

    2016-01-01

    AIMS: High-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I) can modulate glucose metabolism through multiple mechanisms. This study determined the effects of a novel bromodomain and extra-terminal (BET) inhibitor (RVX-208) and putative apoA-I inducer on lipid species contained within HDL...... (HDL lipidome) and glucose metabolism. MATERIALS AND METHODS: Twenty unmedicated males with prediabetes received 100mg b.i.d. RVX-208 and placebo for 29-33days separated by a wash-out period in a randomized, cross-over design trial. Plasma HDL-cholesterol and apoA-I were assessed as well as lipoprotein...... particle size and distribution using NMR spectroscopy. An oral glucose tolerance test (OGTT) protocol with oral and infused stable isotope tracers was employed to assess postprandial plasma glucose, indices of insulin secretion and insulin sensitivity, glucose kinetics and lipolysis. Whole plasma and HDL...

  10. Influência dos teores de aveia e de gordura nas características tecnológicas e funcionais de bolos Influence of oat and fat levels in technological and functional characteristics of cakes

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Gutkoski

    2009-06-01

    Full Text Available O presente trabalho objetivou estudar o emprego de aveia e de gordura nas características tecnológicas e funcionais de bolos. No estudo foram utilizados os ingredientes flocos e farinha de aveia (Avena sativa L. do cultivar IAC 7 (30% de flocos grossos tostados e 70% de farinha, previamente selecionados com base na composição química, farinha de trigo, açúcar, sal, fermento químico, emulsificante, leite em pó, ovo inteiro, sorbitol e aroma de baunilha. O experimento foi realizado em delineamento composto central rotacional aplicável à metodologia de superfície de resposta (MSR, sendo os teores de aveia (flocos, farinha e gordura estabelecidos como variáveis independentes. Os resultados de densidade da massa, viscosidade da massa, composição química, energia metabolizável, volume específico, atividade de água, características internas, porosidade e cor foram tratados por análise de regressão múltipla, obtendo-se modelo matemático de segunda ordem com os termos lineares, quadráticos e de interação significativos. A aveia pode ser utilizada na elaboração de bolos de valor calórico reduzido e como fonte de fibras alimentares atendendo às características de alimento funcional. A densidade da massa variou com a quantidade de gordura da formulação, enquanto que a viscosidade, com a concentração de aveia. A porosidade do miolo foi influenciada pelas concentrações de aveia e de gordura utilizadas nas formulações. Com a elevação do teor de aveia e a diminuição de gordura nas formulações ocorreu um aumento da área, diâmetro e perímetro médios dos alvéolos.The present work aimed to study the use of oat and fat in the technological and functional characteristics of cakes. The ingredients used were oat flakes and flour (Avena sativa L., of the cultivar IAC 7 (30% of toasted thick flakes and 70% of flour, selected based on the chemical composition, wheat flour, sugar, salt, baking powder, emulsifier, powdered

  11. Avaliação da Composição Centesimal, Mineral e Teor de Antocianinas da Polpa de Juçaí (Euterpe edulis Martius

    Directory of Open Access Journals (Sweden)

    Leilson de Oliveira Ribeiro

    2015-07-01

    Full Text Available A polpa de juçaí, fruto da palmeira juçara (Euterpe edulis Martius encontrada nas áreas da Mata Atlântica e a polpa de açaí, fruto da palmeira juçara (Euterpe oleracea Martius cultivado na Floresta Amazônica, foram caracterizadas obtendo assim sua composição centesimal, mineral e também seu teor de antocianinas. Com os resultados obtidos foi possível fazer um estudo comparativo da concentração de antocianinas das duas polpas congeladas e verificar a importância do consumo destes alimentos, classificados como funcionais, devido às propriedades antioxidantes de suas antocianinas no combate dos radicais livres no organismo humano.

  12. A redução vocálica em palavras funcionais produzidas por falantes brasileiros de inglês como língua estrangeira

    OpenAIRE

    Fragozo, Carina Silva

    2010-01-01

    A presente pesquisa tem por objetivo analisar o processo de redução vocálica em palavras funcionais produzidas por falantes de inglês como língua estrangeira (LE). Tomamos como ponto de partida os trabalhos de Watkins (2001), que analisou a redução vocálica por falantes de inglês como LE, e de Marusso (2003), que investigou a redução vocálica por falantes nativos de inglês e de português. A partir dessas duas pesquisas, este trabalho propõe-se a avaliar tanto fatores linguísticos quanto extra...

  13. Resiliência e susceptibilidade de tipos funcionais vegetais na paisagem no semiárido nordestino

    OpenAIRE

    Silva, Milena Dutra da

    2012-01-01

    As plantas possuem grande sensibilidade aos fatores climáticos dominantes no ambiente e por isto a investigação dos seus padrões morfofuncionais são excelentes ferramentas auxiliares para a compreensão do funcionamento da paisagem e/ou ecossistema. Entre os biomas brasileiros, a caatinga se destaca por sua abrangência territorial (54% da região Nordeste e 11% do território nacional) e elevada potencialidade quanto aos recursos naturais. Estas características a tornaram alvo de exploração inte...

  14. Comparison of non-HDL-cholesterol versus triglycerides-to-HDL-cholesterol ratio in relation to cardiometabolic risk factors and preclinical organ damage in overweight/obese children: the CARITALY study.

    Science.gov (United States)

    Di Bonito, P; Valerio, G; Grugni, G; Licenziati, M R; Maffeis, C; Manco, M; Miraglia del Giudice, E; Pacifico, L; Pellegrin, M C; Tomat, M; Baroni, M G

    2015-05-01

    Lipid ratios to estimate atherosclerotic disease risk in overweight/obese children are receiving great attention. We aimed to compare the performance of non-high-density lipoprotein-cholesterol (HDL-C) versus triglycerides-to-HDL-C ratio (Tg/HDL-C) in identifying cardiometabolic risk factors (CMRFs) or preclinical signs of organ damage in outpatient Italian overweight/obese children. In this retrospective, cross-sectional study, 5505 children (age 5-18 years) were recruited from 10 Italian centers for the care of obesity, of which 4417 (78%) showed obesity or morbid obesity. Anthropometric, biochemical, and blood pressure variables were analyzed in all children. Liver ultrasound scan, carotid artery ultrasound, and echocardiography were performed in 1257, 601, and 252 children, respectively. The entire cohort was divided based on the 75th percentile of non-HDL-C (≥130 mg/dl) or Tg/HDL-C ratio (≥2.2). The odds ratio for insulin resistance, high blood pressure, metabolic syndrome, presence of liver steatosis, increased levels of carotid intima-media thickness (cIMT) and concentric left ventricular hypertrophy (cLVH) was higher in children with high levels of Tg/HDL-C with respect to children with high levels of non-HDL-C. In an outpatient setting of overweight/obese children, Tg/HDL-C ratio discriminated better than non-HDL-C children with CMRFs or preclinical signs of liver steatosis, and increased cIMT and cLVH. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Elaboração e caracterização físico-química de antepastos funcionais utilizando kefir e semente de chia / Elaboration and physical-chemical characterization of functional antipasto using kefir and chia seed

    OpenAIRE

    Campolina, Gabriela Aguiar; Faria, Marco Aurélio da Silva; Carvalho, Naiara Barbosa; Villanoeva, Camila Nair Batista

    2017-01-01

    Os alimentos funcionais têm sido cada vez mais conhecidos e consequentemente mais consumidos pela população, devido à preocupação cada vez maior com a saúde e o bem-estar. Dentre os alimentos funcionais, merecem destaque os lácteos funcionais por serem os mais conhecidos pelos consumidores. O kefir, apesar de ser pouco consumido no Brasil é um alimento que proporciona aos consumidores alguns benefícios que merecem ser estudados e disseminados. Partindo dessas características, o presente traba...

  16. Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess.

    Science.gov (United States)

    Samino, Sara; Vinaixa, Maria; Díaz, Marta; Beltran, Antoni; Rodríguez, Miguel A; Mallol, Roger; Heras, Mercedes; Cabre, Anna; Garcia, Lorena; Canela, Nuria; de Zegher, Francis; Correig, Xavier; Ibáñez, Lourdes; Yanes, Oscar

    2015-06-23

    Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide.

  17. Caracterização de acessos de bananeira com base na concentração de compostos funcionais Characterization of banana accessions with base on functional compounds

    Directory of Open Access Journals (Sweden)

    Edson Perito Amorim

    2011-04-01

    Full Text Available O objetivo deste trabalho foi determinar a concentração de polifenóis totais, flavonóides, vitamina C e carotenóides totais em 61 acessos de banana pertencentes ao Banco Ativo de Germoplasma de bananeira da Embrapa Mandioca e Fruticultura. Foram detectadas diferenças significativas para todas as características analisadas por meio da análise de variância. A média para os teores de polifenóis totais entre os 61 acessos de banana foi de 38,06mg 100g-1, com variação de 12,51mg 100g-1 para o triplóide 'Torp' a 257,80mg 100g-1 para o tetraplóide 'Teparod'. A média para flavonóides foi de 2,09mg 100g-1, variando de 0,85mg 100g-1 ('Maravilha' AAAB a 6,63mg 100g-1 ('Teparod' ABBB. Para vitamina C, a média foi de 21,60mg 100g-1, variando de 8,60mg 100g-1 (tetraplóide 'Bucaneiro' a 76,82mg 100g-1 (tetraplóide 'Teparod'. A média do teor de carotenóides totais foi de 4,34mg g-1, variando de 1,18mg g-1 ('Champa Madras', triplóide ABB a 19,24mg g-1 ('Saney', triplóide AAB. Os diplóides Modok Gier e NBA-14 apresentaram, respectivamente, quatro e cinco vezes mais carotenóides totais que as cultivares do grupo Cavendish ('Nanica', 'Willians' e 'Lacatan'. Esses resultados permitem concluir sobre a possibilidade da obtenção de cultivares com altos níveis de compostos funcionais por meio de cruzamentos e seleção. Cultivares com este perfil têm potencial como alimento funcional, ajudando a prevenir doenças, por meio da neutralização de radicais livres.The objective of this research was to determine the concentration of polyphenols, flavonols, vitamin C and carotenoid and in 61 banana accessions from Musa germplasm collection from Embrapa Cassava and Fruits, Brazil. Was detected significant differences for all characteristic analyzed in ANOVA. The average for polyphenols among the 61 accessions was of 38.06mg 100g-1, with variation of 12.51mg 100g-1 for the triploid 'Torp' to 257.80mg 100g-1 for the tetraploid 'Teparod'. The average

  18. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

    OpenAIRE

    Voight, Benjamin F; Peloso, Gina M; Orho-Melander, Marju; Frikke-Schmidt, Ruth; Barbalic, Maja; Jensen, Majken K; Hindy, George; Hólm, Hilma; Ding, Eric L; Johnson, Toby; Schunkert, Heribert; Samani, Nilesh J; Clarke, Robert; Hopewell, Jemma C; Thompson, John F

    2012-01-01

    Summary Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. Methods We performed two mendelian randomisation analyses. Fi...

  19. Enhanced HDL-cholesterol-associated anti-oxidant PON-1 activity in prostate cancer patients

    Directory of Open Access Journals (Sweden)

    Muzaffer Eroglu

    2013-07-01

    Full Text Available Increases in the generation of reactive oxygen species and decreases in antioxidant enzyme activities with aging have been reported in the prostate, and are also observed in age-related disorders such as atherosclerosis, Alzheimer's disease, and cataracts. Several studies have demonstrated that proteins are targets for reactive oxidants in cells, and that oxidized proteins accumulate during aging, oxidative stress and in some pathological conditions. However, only a limited number of studies have actually evaluated oxidative damage in relation to HDL-cholesterol-associated antioxidant enzyme activities or have assessed its relationship with prostate cancer. In this study, we examined the effect of HDL-cholesterol-associated antioxidant enzyme activities, paraoxonase1, arylesterase and new oxidative stress parameters (total oxidant status, total antioxidant status [and oxidative stress index] in newly-diagnosed prostate cancer patients and healthy controls. There were no significant differences in oxidative stress parameters and lipid parameters between prostate cancer patients and controls, however, paraoxonase1 enzyme activity, and non-HDL-cholesterol levels were higher in prostate cancer patients than controls. The results of this study were derived from a small number of subjects, but might represent an important working hypothesis for further research in a larger number of cases to clarify the role of paraoxonase1 overproduction on the prostate and its clinical relevance.

  20. Is the Monocyte/HDL Ratio a Prognostic Marker of Idiopathic Sudden Hearing Loss?

    Science.gov (United States)

    Koçak, Hasan Emre; Acipayam, Harun; Elbistanlı, Mustafa Suphi; Yiğider, Ayşe Pelin; Alakhras, Wesam; Kıral, Mehmet Nurettin; Kayhan, Fatma Tülin

    2016-10-31

    In this study, our aim was to investigate whether Monocyte/HDL ratio is a marker of the prognosis of the idiopathic sudden hearing loss (ISHL). Retrospective, case-control clinical trial. 45 patients, who were diagnosed with idiopathic sudden hearing loss and were treated with the same therapy regime and 47 healthy volunteers, who applied to the hospital for routine controls and had audiological and laboratory examination between March 2014 and December 2015, were included in the study. Monocyte/HDL ratios of the patients in the study and control groups were calculated from the results of the blood counts and biochemical analysis. Additionally, the study group was divided into two sub-groups regarding their responses (responders and non-responders) to the treatment determined by the audiological examination, which was carried out after 3 months according to the Siegel criteria. The Monocyte/HDL ratios between the groups were statistically evaluated. There was no statistically significant difference between the MHRs of the study and control groups (p=0.574). However, the MHR was significantly higher in the non-responders? group compared with the responders? group, although they were treated with the same therapy regimen (p=0.005). There was no difference in MHRs between study and control groups. However, as MHR was higher in the patients with good prognosis compared with the patients with bad prognosis, we believe that regarding the ISHL, MHR is not a predictive value but might have prognostic marker.

  1. Improvement of HDL- and LDL-cholesterol levels in diabetic subjects by feeding bread containing chitosan.

    Science.gov (United States)

    Ausar, S F; Morcillo, M; León, A E; Ribotta, P D; Masih, R; Vilaro Mainero, M; Amigone, J L; Rubin, G; Lescano, C; Castagna, L F; Beltramo, D M; Diaz, G; Bianco, I D

    2003-01-01

    In this work we evaluated the efficacy and safety of a bread formulation containing chitosan in dyslipidemic type 2 diabetic subjects. For this purpose a total of 18 patients were allowed to incorporate to their habitual diets 120 g/day of bread containing 2% (wt/wt) chitosan (chitosan group, n= 9) or standard bread (control group, n= 9). Before the study and after 12 weeks on the modified diet, the following parameters were evaluated: body weight, plasma cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triglyceride, and hemoglobin A(1c) (HbA(1c)). Compared with the control group, the patients receiving chitosan-containing bread decreased their mean levels of LDL-cholesterol and significantly increased their mean levels of HDL-cholesterol at the end of the study. There were no significant differences in the body weight, serum triglyceride, and HbA(1c). These results suggest that chitosan incorporated into bread formulations could improve the lipoprotein balance similar to typical biliary salts trappers, increasing the HDL- and lowering the LDL-cholesterol, without changing the triglyceride levels. These results warrant further studies over a longer period of time to evaluate if a persistent improvement in levels of lipoproteins can be attained with this strategy.

  2. Effect of Theobromine Consumption on Serum Lipoprotein Profiles in Apparently Healthy Humans with Low HDL-Cholesterol Concentrations.

    Science.gov (United States)

    Jacobs, Doris M; Smolders, Lotte; Lin, Yuguang; de Roo, Niels; Trautwein, Elke A; van Duynhoven, John; Mensink, Ronald P; Plat, Jogchum; Mihaleva, Velitchka V

    2017-01-01

    Scope: Theobromine is a major active compound in cocoa with allegedly beneficial effect on high-density-lipoprotein-cholesterol (HDL-CH). We have investigated the effect of theobromine (TB) consumption on the concentrations of triglyceride (TG) and cholesterol (CH) in various lipoprotein (LP) subclasses. Methods: In a randomized, double-blind, placebo-controlled, cross-over study, 44 apparently healthy women and men (age: 60 ± 6 years, BMI: 29 ± 3 kg/m 2 ) with low baseline HDL-CH concentrations consumed a drink supplemented with 500 mg/d theobromine for 4 weeks. TG and CH concentrations in 15 LP subclasses were predicted from diffusion-edited 1 H NMR spectra of fasting serum. Results: The LP phenotype of the subjects was characterized by low CH concentrations in the large HDL particles and high TG concentrations in large VLDL and chylomicron (CM) particles, which clearly differed from a LP phenotype of subjects with normal HDL-CH. TB only reduced CH concentrations in the LDL particles by 3.64 and 6.79%, but had no effect on TG and CH in any of the HDL, VLDL and CM subclasses. Conclusion: TB was not effective on HDL-CH in subjects with a LP phenotype characterized by low HDL-CH and high TG in VLDL.

  3. Effect of Theobromine Consumption on Serum Lipoprotein Profiles in Apparently Healthy Humans with Low HDL-Cholesterol Concentrations

    Directory of Open Access Journals (Sweden)

    Doris M. Jacobs

    2017-08-01

    Full Text Available Scope: Theobromine is a major active compound in cocoa with allegedly beneficial effect on high-density-lipoprotein-cholesterol (HDL-CH. We have investigated the effect of theobromine (TB consumption on the concentrations of triglyceride (TG and cholesterol (CH in various lipoprotein (LP subclasses.Methods: In a randomized, double-blind, placebo-controlled, cross-over study, 44 apparently healthy women and men (age: 60 ± 6 years, BMI: 29 ± 3 kg/m2 with low baseline HDL-CH concentrations consumed a drink supplemented with 500 mg/d theobromine for 4 weeks. TG and CH concentrations in 15 LP subclasses were predicted from diffusion-edited 1H NMR spectra of fasting serum.Results: The LP phenotype of the subjects was characterized by low CH concentrations in the large HDL particles and high TG concentrations in large VLDL and chylomicron (CM particles, which clearly differed from a LP phenotype of subjects with normal HDL-CH. TB only reduced CH concentrations in the LDL particles by 3.64 and 6.79%, but had no effect on TG and CH in any of the HDL, VLDL and CM subclasses.Conclusion: TB was not effective on HDL-CH in subjects with a LP phenotype characterized by low HDL-CH and high TG in VLDL.

  4. A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fat to modulate serum HDL-cholesterol concentrations.

    Science.gov (United States)

    Baik, Inkyung; Lee, Seungku; Kim, Seong Hwan; Shin, Chol

    2013-10-01

    There are limited data from prospective studies regarding interactions between lipoprotein lipase gene (LPL) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk. Our prospective cohort study investigated the interactive effects of a common LPL polymorphism and lifestyle factors, including obesity, smoking, alcohol consumption, physical activity, and dietary intake, on follow-up measurements of HDL-C and triglyceride (TG) concentrations. A total of 5314 Korean men and women aged 40-69 y participated in the study. Serum HDL-C and TG concentrations were measured in all participants at baseline and 6-y follow-up examinations. On the basis of genome-wide association data for HDL-C and TG concentrations, we selected the most significant polymorphism (rs10503669), which was in high linkage disequilibrium with the serine 447 stop (S447×) mutation (D' = 0.99) of LPL. We found that carrying the T allele reflecting the LPL ×447 allele was positively associated with follow-up measurement of HDL-C concentrations (P effects of the polymorphism and consumption of alcohol (P-interaction effects of the polymorphism and body mass index (P-interaction alcohol consumption and a diet high in unsaturated fat to minimize reduction of blood HDL-C concentrations and that obese persons who do not carry the LPL ×447 allele need to control body weight to prevent hypertriglyceridemia.

  5. Evaluation of non-HDL cholesterol as a predictor of non-fatal cardiovascular events in a prospective population cohort.

    Science.gov (United States)

    Carbayo Herencia, Julio A; Simarro Rueda, Marta; Palazón Bru, Antonio; Molina Escribano, Francisca; Ponce García, Isabel; Artigao Ródenas, Luis Miguel; Caldevilla Bernardo, David; Divisón Garrote, Juan A; Gil Guillén, Vicente Francisco

    2018-01-27

    Non-HDL cholesterol (non-HDL-C) is becoming relevant both in its participation in cardiovascular risk assessment and as a therapeutic target. The objective of the present study was to assess the independent predictive capacity of both non-HDL-C and LDL-C (the main priority in dyslipidemias to reduce cardiovascular risk), in cardiovascular morbidity in a population-based sample. A prospective cohort study involving 1186 individuals in the non-HDL-C group and 1177 in the LDL-C group, followed for 10.7years (SD=2.2), who had not had any previous cardiovascular event. The predictor variables included in the adjustment were: gender, age, arterial hypertension, diabetes mellitus, smoker status and non-HDL-C in one group. In the other group, consisting of patients presenting TG levels of 400mg/dL, non-HDL-C was replaced by LDL-C. Survival curves (Kaplan-Meier) were calculated and two Cox regression models were applied, one for each group. Non-HDL-C group presented 6.2% of non-fatal cardiovascular episodes during follow-up and the LDL-C group 6.0%. After adjustment, for each 30mg/dL increase in non-HDL-C, the incidence of new non-fatal cardiovascular events increased by 31% (HR=1.31, 95%CI: 1.06-1.61; P=.018) and in the LDL-C group by 27% (HR=1.27, 95%CI: 0.97-1.61, P=.068). After a follow-up of 10.7years, non-HDL-C has been shown in our population as a prognostic factor of non-fatal cardiovascular disease, but not LDL-C, although its HR is close to statistical significance. Copyright © 2017 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

  6. HDL levels and oxidizability during myocardial infarction are associated with reduced endothelial-mediated vasodilation and nitric oxide bioavailability.

    Science.gov (United States)

    Carvalho, Luiz Sergio F; Panzoldo, Natália; Santos, Simone N; Modolo, Rodrigo; Almeida, Breno; Quinaglia E Silva, Jose C; Nadruz, Wilson; de Faria, Eliana C; Sposito, Andrei C

    2014-12-01

    Acute phase response modifies high-density lipoprotein (HDL) into a dysfunctional particle that may favor oxidative/inflammatory stress and eNOS dysfunction. The present study investigated the impact of this phenomenon on patients presenting ST-elevation myocardial infarction (STEMI). Plasma was obtained from 180 consecutive patients within the first 24-h of onset of STEMI symptoms (D1) and after 5 days (D5). Nitrate/nitrite (NOx) and lipoproteins were isolated by gradient ultracentrifugation. The oxidizability of low-density lipoprotein incubated with HDL (HDLaoxLDL) and the HDL self-oxidizability (HDLautox) were measured after CuSO4 co-incubation. Anti-inflammatory activity of HDL was estimated by VCAM-1 secretion by human umbilical vein endothelial cells after incubation with TNF-α. Flow-mediated dilation (FMD) was assessed at the 30(th) day (D30) after STEMI. Among patients in the first tertile of admission HDL-Cholesterol (42 mg/dL) tertiles, respectively. From D1 to D5, there was a decrease in HDL size (-6.3 ± 0.3%; p < 0.001) and particle number (-22.0 ± 0.6%; p < 0.001) as well as an increase in both HDLaoxLDL (33%(23); p < 0.001) and HDLautox (65%(25); p < 0.001). VCAM-1 secretion after TNF-a stimulation was reduced after co-incubation with HDL from healthy volunteers (-24%(33); p = 0.009), from MI patients at D1 (-23%(37); p = 0.015) and at D30 (-22%(24); p = 0.042) but not at D5 (p = 0.28). During STEMI, high HDL-cholesterol is associated with a greater decline in endothelial function. In parallel, structural and functional changes in HDL occur reducing its anti-inflammatory and anti-oxidant properties. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  7. Diagnóstico da doença de Alzheimer com base no electroencefalograma

    OpenAIRE

    Rodrigues, Pedro Miguel de Luís

    2011-01-01

    A Doença de Alzheimer (DA) é a forma mais comum de demência. A esperança média de vida está a aumentar e esta patologia surge associada à idade, o que é preocupante. Para se alcançar um diagnóstico precoce e preciso desta doença é necessário optimizar os métodos da sua detecção. A análise de sinais do electroencefalograma (EEG) pode ser reveladora de deficiências estruturais e funcionais associadas à DA. Por conseguinte, este trabalho teve por finalidade a análise de EEGs da activ...

  8. Restaurações estéticas e funcionais de dentes anteriores decíduos

    OpenAIRE

    Rocha, Marta de Mendonça

    2017-01-01

    Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2017 Introdução: A manutenção da dentição decídua é importante para o bem-estar geral da criança. A cárie dentária, as pigmentações, os traumatismos, a perda precoce de dentes, os maus posicionamentos dentários ou qualquer outra anomalia de forma e tamanho dos dentes, podem contribuir para uma estética insatisfatória. Os problemas estéticos em odontopediatria podem ser solucionados de diferentes fo...

  9. Novos métodos funcionais na avaliação de lesões mamárias

    Directory of Open Access Journals (Sweden)

    Filipe Ramos Barra

    2012-12-01

    Full Text Available O câncer de mama é um dos mais prevalentes nas mulheres. A mamografia é um excelente método com impacto comprovado na redução da mortalidade pelo câncer de mama. Porém, não é um método perfeito, apresentando alguns pontos fracos, principalmente no rastreamento de mulheres com mamas densas, estadiamento e avaliação de tratamento. A ressonância magnética mamária mostrou a necessidade e importância da avaliação funcional mamária. Descrevemos dois métodos de avaliação funcional mamária e demonstramos nossa experiência com a mamografia digital com contraste e com a imagem molecular mamária realizada em gama-câmara específica. Estes dois métodos já estão disponíveis em nosso meio e apresentam resultados promissores na detecção de lesões mamográficas ocultas, confirmação de lesões suspeitas e redução de biópsias desnecessárias, podendo assim melhorar o estudo mamário, principalmente nos pontos falhos da mamografia.

  10. Desenvolvimento e caracterização físico-química de sistemas líquido cristalinos contendo palmitato de retinol: quantificação química, avaliação da atividade antioxidante, estudos de liberação e bioadesão in vitro

    OpenAIRE

    Oliveira, Paula Lacerda [UNESP

    2011-01-01

    As hipóteses mais modernas baseiam o processo de envelhecimento cutâneo em duas teorias: o intrínseco (ou cronológico) e o extrínseco (ou fotoenvelhecimento). Tanto no envelhecimento intrínseco como no extrínseco, as principais alterações da pele são caracterizadas por formação de rugas, flacidez e perda da elasticidade. O palmitato de retinol (PR) é um análogo sintético da vitamina A indicado topicamente para prevenir ou retardar algumas mudanças estruturais e funcionais da pele associadas a...

  11. U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies.

    Science.gov (United States)

    Madsen, Christian M; Varbo, Anette; Tybjærg-Hansen, Anne; Frikke-Schmidt, Ruth; Nordestgaard, Børge G

    2017-12-08

    Preclinical evidence has indicated that HDL may play an important role in the immune system; however, very little is known about the role of HDL in the immune system in humans. We tested the hypothesis that low and high concentrations of HDL cholesterol are associated with risk of infectious disease in the general population. We included 97 166 individuals from the Copenhagen General Population Study and 9387 from the Copenhagen City Heart Study with measurements of HDL cholesterol at baseline. The primary endpoint was any infectious disease requiring hospital admission, ascertained in the Danish health registries from baseline in 2003-13 or 1991-94 through 2014; 9% and 31% of individuals in the two studies experienced one or more infectious disease events. Using restricted cubic splines, there was a U-shaped association between concentrations of HDL cholesterol and risk of any infection. Following multifactorial adjustment, individuals with HDL cholesterol below 0.8 mmol/L (31 mg/dL) and above 2.6 mmol/L (100 mg/dL) had hazard ratios for any infection of 1.75 (95% confidence interval 1.31-2.34) and 1.43 (1.16-1.76), compared to those with HDL cholesterol of 2.2-2.3 mmol/L (85-95 mg/dL). In the Copenhagen City Heart Study, corresponding hazard ratios for any infection were 2.00 (1.16-3.43) and 1.13 (0.80-1.60). Low and high HDL cholesterol concentrations found in 21% and 8% of individuals were associated with higher risk of infectious disease in the general population. These findings do not necessarily indicate causality. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.

  12. Structural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometry.

    Science.gov (United States)

    Cao, Jian; Hsu, Yuan-Hao; Li, Sheng; Woods, Virgil L; Dennis, Edward A

    2013-01-01

    Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), specifically Group VIIA PLA(2), is a member of the phospholipase A(2) superfamily and is found mainly associated with LDL and HDL in human plasma. Lp-PLA(2) is considered as a risk factor, a potential biomarker, a target for therapy in the treatment of cardiovascular disease, and evidence suggests that the level of Lp-PLA(2) in plasma is associated with the risk of future cardiovascular and stroke events. The differential location of the enzyme in LDL/HDL lipoproteins has been suggested to affect Lp-PLA(2) function and/or its physiological role and an abnormal distribution of the enzyme may correlate with diseases. Although a mutagenesis study suggested that a surface helix (residues 362-369) mediates the association between Lp-PLA(2) and HDL, the molecular details and mechanism of association has remained unknown. We have now employed hydrogen deuterium exchange mass spectrometry to characterize the interaction between recombinant human Lp-PLA(2) and human HDL. We have found that specific residues 113-120, 192-204, and 360-368 likely mediate HDL binding. In a previous study, we showed that residues 113-120 are important for Lp-PLA(2)-liposome interactions. We now find that residues 192-204 show a decreased deuteration level when Lp-PLA(2) is exposed to apoA-I, but not apoA-II, the most abundant apoproteins in HDL, and additionally, residues 360-368 are only affected by HDL.The results suggest that apoA-I and phospholipid membranes play crucial roles in Lp-PLA(2) localization to HDL.

  13. Reestruturação da gordura do leite por mistura e interesterificação com óleo de milho.

    OpenAIRE

    Juliana Neves Rodrigues

    2002-01-01

    O consumidor está se tornando mais consciente da relação entre alimentação e doenças, o que tem impulsionado as pesquisas na área de alimentos funcionais e seus efeitos no organismo. As gorduras são um importante componente da dieta humana, porém a dieta ocidental apresenta um desequilíbrio quanto ao tipo de gordura consumida. As gorduras saturadas são consumidas em grande quantidade, o que pode provocar doenças cardiovasculares, que atualmente constituem a principal causa de morte no Brasil....

  14. Estratégia competitiva em MPEs: dimensões do processo e suas associações com as estratégias genéricas e funcionais

    Directory of Open Access Journals (Sweden)

    Brigitte Renata Bezerra de Oliveira

    2015-03-01

    Full Text Available Este artigo buscou compreender as relações entre as dimensões do processo estratégico: pensamento, formação e mudança e as estratégias genéricas e funcionais em MPEs situadas no Vale do São Francisco. A amostra considera 271 respondentes e os resultados evidenciam que os dirigentes tendem a utilizar mais o pensamento lógico do que intuitivo, a formar a estratégia de maneira mais emergente do que deliberada e promover mudanças mais evolutivas do que revolucionárias. Ressalta-se ainda que não houve relação significativa entre o processo estratégico e as estratégicas genéricas e funcionais efetivamente adotadas pelas firmas.

  15. Possíveis alterações no mecanismo minimizador de energia da caminhada em decorrência da dor lombar crônica - revisão de literatura

    Directory of Open Access Journals (Sweden)

    Alberito Rodrigo de Carvalho

    2015-02-01

    Full Text Available Um dos objetivos da marcha é deslocar o corpo no espaço da forma mais econômica possível. Porém, pouco se sabe como os aspectos mecânicos e energéticos da caminhada são afetados pela dor lombar. Ainda, caso haja prejuízos, é pequeno o conhecimento de como as características mecânicas e energéticas da caminhada se manifestam nas atividades funcionais, principalmente nos mecanismos minimizadores de energia da locomoção. Este estudo teve por objetivos: a descrever os principais mecanismos minimizadores de energia da locomoção; e b verificar se há indicativos de prejuízos nas características mecânicas e energéticas da caminhada decorrentes da dor lombar crônica (DLC que possam comprometer os mecanismos minimizadores. Estudo caracterizado como revisão narrativa de literatura. A principal teoria que explica a minimização do dispêndio energético durante a caminhada é a do pêndulo invertido pelo qual o mecanismo minimizador converte energia cinética em energia potencial do centro de massa e vice-versa durante a passada. Esse mecanismo é fortemente influenciado por parâmetros espaços-temporais da marcha, tais como comprimento de passo e velocidade preferida da caminhada, que, por sua vez, podem estar severamente alterados em pacientes com dor lombar crônica. Contudo ainda há muito que se entender sobre os efeitos da dor lombar crônica sobre a capacidade do indivíduo de praticar uma marcha econômica, pois os prejuízos funcionais podem comprometer características mecânicas e energéticas dessa modalidade de marcha e torná-la mais dispendiosa. Desta forma, há indicativos de que tais mudanças funcionais possam comprometer os mecanismos minimizadores de energia.

  16. Treatment of HIV infection with a raltegravir-based regimen increases LDL levels, but improves HDL cholesterol efflux capacity.

    Science.gov (United States)

    Funderburg, Nicholas T; Xu, Dihua; Playford, Martin P; Joshi, Aditya A; Andrade, Adriana; Kuritzkes, Daniel R; Lederman, Michael M; Mehta, Nehal N

    2017-01-01

    Persons infected with HIV often have altered lipid profiles that may be affected by antiretroviral therapies (ART). Traditional lipid measurements may be insufficient to assess cardiovascular disease (CVD) risk in this population. We report results from 39 ART-naive participants in a substudy of A5248, a single-arm study of raltegravir, emtricitabine/tenofovir administration. Samples were collected at baseline, 12, 24 and 48 weeks after ART initiation. We performed advanced lipid phenotyping using nuclear magnetic resonance spectroscopy (Liposcience, Raleigh, NC, USA) for lipid particle size and number, and examined high-density lipoprotein (HDL) function measuring reverse cholesterol transport using J774 macrophages. We report significant increases in total cholesterol (13 mg/dl; PLDL; 8 mg/dl; P=0.03), with no change in triglycerides and without an increase in LDL particle number (P>0.1 all time points). HDL levels were increased over baseline levels at all time points (PLDL (oxLDL) levels decreased by week 12, but rose subsequently, and were not different from baseline at later time points. HDL increases were associated with increases in beneficial HDL particles and HDL cholesterol efflux capacity, which may reduce future CVD events. Persistent inflammation in these HIV+ participants, may be a cause or consequence of oxLDL levels, and may contribute to declining levels of HDL over time. Clinicaltrials.gov NCT00660972.

  17. Comparison of effects of diet versus exercise weight loss regimens on LDL and HDL particle size in obese adults

    Directory of Open Access Journals (Sweden)

    Klempel Monica C

    2011-07-01

    Full Text Available Abstract Background Obesity is associated with an atherogenic lipid profile characterized by a predominance of small LDL and HDL particles. Weight loss, by dietary restriction or exercise, increases LDL particle size. Whether these interventions can augment HDL size in conjunction with LDL size remains unknown. Objective This study compared the effects of alternate day fasting (ADF, calorie restriction (CR, and endurance exercise on LDL and HDL particle size in overweight and obese subjects. Methods In a 12-week parallel-arm trial, adult subjects (n = 60 were randomized to 1 of 4 groups: 1 ADF (75% energy restriction for 24-h alternated with ad libitum feeding for 24-h, 2 CR (25% energy restriction every day, 3 exercise (moderate intensity training 3 x/week, or 4 control. Results Body weight was reduced (P P P P = 0.01 by ADF and CR. The proportion of small LDL particles decreased (P = 0.04 with ADF only, and the proportion of large HDL particles increased (P = 0.03 with exercise only. Conclusion These results indicate that dietary restriction increases LDL particle size, while endurance training augments HDL particle size, with minimal weight loss. None of these interventions concomitantly increased both LDL and HDL particle size, however.

  18. Correlatos anatômico-funcionais das emoções mapeados com técnicas de neuroimagem funcional

    Directory of Open Access Journals (Sweden)

    Geraldo Busatto

    2006-01-01

    Full Text Available Nos dias de hoje, o uso de técnicas de neuroimagem funcional permite investigações detalhadas dos circuitos cerebrais engajados durante o desempenho de paradigmas de estimulação que envolvem diferentes aspectos do processamento emocional em seres humanos saudáveis. Este artigo discute os princípios básicos dos métodos mais comumente usados em estudos de neuroimagem funcional das emoções, faz uma revisão seletiva de achados recentes obtidos nestes estudos, fornece exemplos de novos paradigmas usados atualmente neste tipo de investigação, e descreve modelos neuroanatômicos recentes para o processamento emocional formulados a partir dos achados da literatura contemporânea de neuroimagem. Por fim, enfatizamos o potencial das técnicas de neuroimagem funcional para ampliar o conhecimento a respeito da ação modulatória dos medicamentos usados para tratar condições mentais que alteram processos emocionais específicos, tais como a depressão e os transtornos de ansiedade.

  19. Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children

    Directory of Open Access Journals (Sweden)

    Maria Wany Louzada Strufaldi

    Full Text Available Summary Objective: To describe the values of non-HDL cholesterol (NHDL-c and the frequency of a family history of early cardiovascular disease (family HCVD in healthy prepubescent children. Analyze the association between NHDL-c and family HCVD, and possible associations with other risk factors for cardiovascular disease (CVD. Method: Cross-sectional study including 269 prepubescent (aged 6-10 years schoolchildren with a normal body mass index (+1SD-2SD. Data collected: Family HCVD; weight and height, waist circumference and systemic blood pressure; lipid profile (total cholesterol TC, HDL-c, triglycerides and LDL-c, NHDL-c calculation (CT-HDL-c, cut-off = 145 mg/dL and insulin resistance (HOMA-IR. Results: High levels were found for NHDL-c in 10 (3.7% of these schoolchildren, and family early HCVD was found in 46 (17.1% of them. There was a weak association between family HCVD and NHDL-c (Cramer’s-V-test = 0.120; p=0.050. Among the children with NHDL-c≥145 mg/dL, 4 (40% have family HCVD. The presence of family HCVD was not associated with the variables being studied. The variables independently associated with NHDL-c ≥ 145 mg/dL were: HOMA-IR (OR=1.7; 95CI 1.1-2.6 and diastolic blood pressure (OR=1.1; 95CI 1.02-1.2. Conclusion: NHDL-c values were associated with blood pressure and insulin resistance. Family HCVD was not associated with other classic risk factors for CVD, even though the frequency found was five times higher than that of high NHDL-c.

  20. An overview of review guidelines for HDL programmable devices in nuclear safety systems

    International Nuclear Information System (INIS)

    Komanduri, Raghavan; Srivani, L.; Thirugnana Murthy, D.

    2013-01-01

    HDL programmable devices viz. CPLDs and FPGAs are increasingly being used to implement digital designs in the I and C systems performing safety functions of nuclear power plants. Synthesizable RTL descriptions manually written in HDLs are the first step in developing industry standard large scale digital designs. The reliability of the implementation is determined by the methodologies followed by the designer during development. Very few guidelines on HPD design practices, specific to nuclear industry are available. This paper presents an overview of the existing guidelines such as IEC 62566 and U.S. NRC's 'Review guidelines for FPGAs in nuclear power plant safety systems'. (author)

  1. PENGARUH PEMBERIAN EKSTRAK PEPAYA TERHADAP KADAR KOLESTEROL TOTAL, LDL DAN HDL DARAH TIKUS PUTIH JANTAN HIPERKOLESTEROLEMIA

    Directory of Open Access Journals (Sweden)

    Endrinaldi Endrinaldi

    2012-05-01

    Full Text Available AbstrakPepaya mengandung pektin yang merupakan serat larut air. Pektin berkemampuan mengikat asam empedu dan dieliminasi keluar tubuh melalui feses. Penurunan jumlah asam empedu di lumen usus menyebabkan hepar menggunakan kolesterol dalam darah untuk membentuk asam empedu. Hal tersebut mengakibatkan penurunan jumlah kolesterol.Tujuan studi ini adalah untuk melihat pengaruh pemberian ekstrak pepaya mengkal terhadap kadar kolesterol total, HDL dan LDL tikus putih. Desain penelitian ini adalah eksperimental menggunakan 20 ekor tikus putih jantan yang dibagi menjadi empat kelompok, yaitu kelompok kontrol, dan kelompok perlakuan dengan pemberian ekstrak pepaya dengan dosis 0,5 ml, 1 ml dan 1,5 ml per 200g/BB melalui oral selama 15 hari.Hasil penelitian menunjukkan terjadinya penurunan rerata kadar kolesterol total, LDL, dan peningkatan kadar HDL serum tikus setelah pemberian ekstrak pepaya selama 15 hari secara bermakna (p<0,05. Tetapi tidak terjadi perbedaan yang bermakna (p>0,05 antara kelompok yang diberi ekstrak pepaya dengan dosis 0,5 ml, 1 ml, dan 1,5 ml.Kesimpulan yang dapat diambil dari studi ini ialah bahwa ekstrak pepaya dapat menurunkan kadar kolesterol total, LDL, dan peningkatan kadar HDL pada serum tikus putih jantanKata kunci : pektin, kolesterol, asam empedu, serat, tikus.AbstractPapaya contain pectin which is a water-soluble fiber. Pectin has the ablity to bind bile acids and eliminated out of the body through the feces. Decrease in the amount of bile acids in intestinal lumen causing liver uses cholesterol to synthesize bile acids blood.The purpose of this study was to see the effect of papaya extract on total cholesterol, HDL and LDL of male rats. This is an experimental research design using 20 white male rats were divided into four groups : control group and group treated with papaya extract a dose of 0,5 ml, 1 ml per 200 gr/body weight orally for 15 days.Results showed a decrease in everage total cholesterol, LDL and increased

  2. Statin action enriches HDL3 in polyunsaturated phospholipids and plasmalogens and reduces LDL-derived phospholipid hydroperoxides in atherogenic mixed dyslipidemia

    Science.gov (United States)

    Tan, Ricardo; Giral, Philippe; Robillard, Paul; Kontush, Anatol; Chapman, M. John

    2016-01-01

    Atherogenic mixed dyslipidemia associates with oxidative stress and defective HDL antioxidative function in metabolic syndrome (MetS). The impact of statin treatment on the capacity of HDL to inactivate LDL-derived, redox-active phospholipid hydroperoxides (PCOOHs) in MetS is indeterminate. Insulin-resistant, hypertriglyceridemic, hypertensive, obese males were treated with pitavastatin (4 mg/day) for 180 days, resulting in marked reduction in plasma TGs (−41%) and LDL-cholesterol (−38%), with minor effects on HDL-cholesterol and apoAI. Native plasma LDL (baseline vs. 180 days) was oxidized by aqueous free radicals under mild conditions in vitro either alone or in the presence of the corresponding pre- or poststatin HDL2 or HDL3 at authentic plasma mass ratios. Lipidomic analyses revealed that statin treatment i) reduced the content of oxidizable polyunsaturated phosphatidylcholine (PUPC) species containing DHA and linoleic acid in LDL; ii) preferentially increased the content of PUPC species containing arachidonic acid (AA) in small, dense HDL3; iii) induced significant elevation in the content of phosphatidylcholine and phosphatidylethanolamine (PE) plasmalogens containing AA and DHA in HDL3; and iv) induced formation of HDL3 particles with increased capacity to inactivate PCOOH with formation of redox-inactive phospholipid hydroxide. Statin action attenuated LDL oxidability Concomitantly, the capacity of HDL3 to inactivate redox-active PCOOH was enhanced relative to HDL2, consistent with preferential enrichment of PE plasmalogens and PUPC in HDL3. PMID:27581680

  3. Hubungan Kadar Trigliserida dan Kolesterol-HDL Terhadap Kadar Alanine Aminotransferase pada Pasien Non Alcoholic Fatty Liver Disease

    Directory of Open Access Journals (Sweden)

    Bayu Gemilang

    2016-01-01

    Full Text Available AbstrakTrigliserida dan Kolesterol HDL (c-HDL merupakan beberapa dari komponen Sindroma Metabolik (SM. SM dipercaya merupakan faktor utama penyebab Non Alcoholic Fatty Liver Disease (NAFLD. NAFLD merupakan penyakit hati kronik yang nantinya dapat menyebabkan fibrosis sel-sel hepar dan juga keganasan. NAFLD tidak menunjukkan manifestasi klinis yang khas, sehingga diperlukan pemeriksaan penunjang seperti pemeriksaan enzim hati untuk menegakkan diagnosis. Alanine Aminotransferase (ALT menjadi pilihan sebagai marker pada penyakit NAFLD. Tujuan penelitian ini adalah menentukan hubungan antara trigliserida dan c-HDL dengan ALT pada penderita NAFLD. Ini merupakan penelitian analitik deskriptif dengan desain retrospektif menggunakan data pasien NAFLD di instalasi rekam medik RSUP dr.M.Djamil Padang. Sampel penelitian ini adalah 51 pasien NAFLD. Hasil penelitian didapatkan dari uji korelasi pearson terdapat derajat hubungan yang kuat (r=0,512 dan hubungan yang bermakna (p<0,001 antara kadar trigliserida dengan kadar ALT serum dan derajat hubungan yang sedang (r=0,26 dan hubungan yang tidak bermakna (p=0,065 antara c-HDL dengan ALT serum. Kesimpulan penelitian ini adalah kadar ALT berhubungan dengan kadar trigliserida pada penderita NAFLD, namun tidak dengan c-HDLKata kunci: NAFLD, trigliserida, HDL, ALT, sindroma metabolik AbstractTriglyceride and HDL Cholesterol (HDL-C are some of the Metabolic Syndrome (MS components. MS is believed as the main factor for the Non Alcoholic Fatty Liver Disease (NAFLD. NAFLD is a chronic liver disease, which later can cause hepatocyte fibrosis and also malignancy. NAFLD does not show a typical clinical appearance, so it is important to do workups such as liver enzyme test to make the diagnosis. Alanine Aminotransferase (ALT is considered as the marker of NAFLD.The objective of this study was to determine the relationship between triglycerides and HDL-C to ALT level in NAFLD patients.This  was a descriptive analytical

  4. Insetos aquáticos associados a macrófitas da região litoral da represa do Ribeirão das Anhumas (município de Américo Brasiliense, São Paulo, Brasil)

    OpenAIRE

    Peiró,Douglas Fernando; Alves,Roberto da Gama

    2006-01-01

    As pesquisas sobre insetos aquáticos vem sendo muito difundidas nos últimos anos. Entretanto, existem lacunas sobre o conhecimento de suas relações com macrófitas aquáticas. O objetivo deste trabalho foi analisar a composição e estrutura da entomofauna associada a seis gêneros de macrófitas da represa do Ribeirão das Anhumas (Américo Brasiliense/SP), avaliar as categorias funcionais tróficas dos insetos, comparar as similaridades faunísticas entre os períodos de coletas e entre as macrófitas ...

  5. Aspectos estruturais e funcionais do apoio social de idosos do Município de São Paulo, Brasil Structural and functional aspects of social support for the elderly in the city of São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Tereza Etsuko da Costa Rosa

    2007-12-01

    Full Text Available Este trabalho teve como objetivo descrever a distribuição das redes sociais e de apoio em idosos no Município de São Paulo, Brasil, por características sócio-econômicas e demográficas. Estudou-se amostra probabilística de 1.568 idosos (60 ou mais anos da cidade de São Paulo (inquérito sobre Saúde, Bem-estar e Envelhecimento - SABE, focalizando-se as dimensões estruturais e funcionais das redes sociais. Para a análise dos dados utilizou-se a regressão logística simples e múltipla. As melhores condições nas redes sociais foram observadas nos menores patamares de renda e as piores entre os mais velhos e os "não casados". Para as mulheres, as chances de estarem "não casadas" aumentaram significativamente quanto pior era o seu nível educacional. O "status de coabitação" foi o que mais influenciou o apoio funcional, onde "morar só" aumentou significativamente as chances de não ocorrerem as trocas sociais. Os modelos de regressão logística múltipla construídos separadamente por gênero sugerem que idade, estado civil, renda per capita e escolaridade estão associados com as redes sociais entre os idosos. No entanto, essas relações manifestam-se de modos desiguais entre gêneros e entre as características sócio-demográficas para as diferentes dimensões da rede social.This study aimed to describe the distribution of social support networks for the elderly in the City of São Paulo, Brazil, based on socioeconomic and demographic characteristics. A probability sample of 1,568 elderly persons (> 60 years was studied (SABE query, focusing on structural and functional dimensions of social networks. Univariate and multiple logistic regression models were used to analyze the data. The best conditions in social networks were in the lowest income levels and the worst among older and unmarried people. For women, unmarried marital status was significantly associated with lower schooling. Cohabiting had the strongest influence on

  6. MOTIVAÇÕES DE CONSUMO, BENEFÍCIOS VALORIZADOS E SATISFAÇÃO DOS CONSUMIDORES DE PRODUTOS LÁCTEOS FUNCIONAIS

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    Rodrigo de Carvalho Leite

    2012-04-01

    Full Text Available Nesta pesquisa procurou-se identificar as principais motivações de consumo, benefícios mais valorizados e o grau de satisfação dos consumidores de produtos lácteos funcionais. Uma survey via Internet foi realizada com 423 consumidores. A amostra representa, predominantemente, consumidores do sexo feminino (57,9%, com idade entre 25-44 anos (68,6%, com renda familiar entre 3-10 salários mínimos (48%, com ensino superior (29,8% ou com pós-graduação (70,2%. Os principais resultados auferidos neste estudo indicam que a principal motivação de consumo está relacionada à "manter hábitos de vida saudáveis" e o benefício funcional mais valorizado nessa categoria de produtos é o auxílio no funcionamento do intestino -relacionado ao consumo de fibras alimentares. Finalmente, 54,9% dos consumidores entrevistados declaram-se "satisfeitos" e "muito satisfeitos" com os benefícios percebidos após o consumo dessa categoria de produto.

  7. Coconut oil increases HDL-c and decreases triglycerides in wistar rats

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    Lidiani Figueiredo Santana

    2016-09-01

    Full Text Available Changes in body composition and serum lipid profile in rats, supplemented with coconut oil, are evaluated and compared to other lipid sources. Female Wistar rats received by gavage 1 mL kg-1 of saline, soybean oil, lard or coconut oil during 21 days. At the end of the study period, body composition, food intake, feces, urine, organ weight and serum lipid profile were assessed. No statistical differences between the groups were found in body composition, food intake, fecal and urinary analysis, and organ weight. In the case or plasma lipid concentrations, coconut oil and lard raised total cholesterol levels, without changes in LDL levels. On the other hand there was no change in total cholesterol levels in the soybean oil group. HDL fraction increased in all groups when compared to that in the saline group; this increase was more significant in the coconut oil group. There was significant reduction of serum triglycerides only in the coconut oil group when compared to the saline group. Supplementation with coconut oil did not interfere in weight and body composition of the animals used in current study, but revealed significant effect on the increase of HDL-c levels and decrease of serum triglycerides.

  8. Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport

    Science.gov (United States)

    Ikhlef, Souade; Berrougui, Hicham; Kamtchueng Simo, Olivier; Zerif, Echarki

    2017-01-01

    This study was aimed to investigate the effect of human PON1 overexpression in mice on cholesterol efflux and reverse cholesterol transport. PON1 overexpression in PON1-Tg mice induced a significant 3-fold (pparaoxonase activity and a significant ~30% (p<0.0001) increase in the capacity of HDL to mediate cholesterol efflux from J774 macrophages compared to wild-type mice. It also caused a significant 4-fold increase (p<0.0001) in the capacity of macrophages to transfer cholesterol to apoA-1, a significant 2-fold (p<0.0003) increase in ABCA1 mRNA and protein expression, and a significant increase in the expression of PPARγ (p<0.0003 and p<0.04, respectively) and LXRα (p<0.0001 and p<0.01, respectively) mRNA and protein compared to macrophages from wild-type mice. Moreover, transfection of J774 macrophages with human PON1 also increased ABCA1, PPARγ and LXRα protein expression and stimulates macrophages cholesterol efflux to apo A1. In vivo measurements showed that the overexpression of PON1 significantly increases the fecal elimination of macrophage-derived cholesterol in PON1-Tg mice. Overall, our results suggested that the overexpression of PON1 in mice may contribute to the regulation of the cholesterol homeostasis by improving the capacity of HDL to mediate cholesterol efflux and by stimulating reverse cholesterol transport. PMID:28278274

  9. A VLSI Implementation of Four-Phase Lift Controller Using Verilog HDL

    Science.gov (United States)

    Kumar, Manish; Singh, Priyanka; Singh, Shesha

    2017-08-01

    With the advent of an era of staggering range of new technologies to provide ease of mobility and transportation elevators have become an essential component of all high rise buildings. An elevator is a type of vertical transportation that moves people between the floors of a high rise building. A four-Phase lift controller modeled on Verilog HDL code using Finite State Machine (FSM) has been presented in this paper. Verilog HDL helps in automated analysis and simulation of lift controller circuit. This design is based on synchronous input that operates on a fixed frequency. The Lift motion is controlled by means of accepting the destination floor level as input and generate control signal as output. In the proposed design a Verilog RTL code is developed and verified. Project Navigator of XILINX has been used as a code writing platform and results were simulated using Modelsim 5.4a simulator. This paper discusses the overall evolution of design and also discusses simulated results.

  10. Qualidade de leites fermentados funcionais elaborados a partir de bactérias ácido-lácticas isoladas de queijo de coalho Quality of functional fermented milks produced by the use of lactic acid bacteria isolated from coalho cheese

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    R.P. Viegas

    2010-04-01

    Full Text Available Leites fermentados foram elaborados a partir de bactérias ácido-lácticas com propriedades funcionais, isoladas de queijo de coalho com e sem a adição de concentrado proteico de soro (CPS. Características físico-químicas, microbiológicas e sensoriais dos produtos elaborados foram analisadas durante 40 dias de estocagem sob refrigeração a 8-10ºC. Todos os leites fermentados elaborados, independentemente da adição de CPS e da cultura utilizada, apresentaram contagens adequadas de bactérias (>10(8UFC/mL durante todo o período de avaliação, o que garantiria seu possível potencial funcional. Leites fermentados por Lactobacillus acidophilus apresentaram melhor aceitação (PFermented milks were produced using whey protein concentrate (WPC and potentially functional lactic acid bacteria, which were isolated from coalho cheese produced in. Physical-chemical, microbiological, and sensorial characteristics of the fermented milks were analyzed during 40 days under refrigeration at 8-10ºC. All products, irrespectively of WPC adding or culture used, showed appropriated bacterial counts (>10(8CFU/mL throughout the evaluation time, which would guarantee their functional potential. Lactobacillus acidophilus fermented milks presented better sensorial approval (P<0.05 when evaluated at 10-day storage; while Weissella confusa fermented milks presented lower acceptance (P<0.05 at 40-day storage. The association of Lactobacillus acidophilus and Weissella confusa or Lactobacillus acidophilus isolatedly, irrespectively of WPC adding, should be recommended for the industrial elaboration of novel functional fermented milks using Brazilian lactic cultures as starters.

  11. Very low levels of HDL cholesterol and atherosclerosis, a variable relationship – a review of LCAT deficiency

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    Savel J

    2012-06-01

    Full Text Available Julia Savel,1,2 Marianne Lafitte,1 Yann Pucheu,1,3 Vincent Pradeau,1 Antoine Tabarin,2,3 Thierry Couffinhal1,3,41Centre d'Exploration, de Prévention et de Traitement de l'Athérosclérose, Hôpital Cardiologique, 2Service d'endocrinologie, CHU Bordeaux, Université Bordeaux Segalen, Bordeaux, France; 3Université de Bordeaux Adaptation cardiovasculaire à l'ischémie, 4INSERM, Adaptation cardiovasculaire à l'ischémie, U1034, Pessac, FranceAbstract: A number of epidemiological and clinical studies have demonstrated that plasma high-density lipoprotein (HDL level is a strong inverse predictor of cardiovascular events. HDL is believed to retard the formation of atherosclerotic lesions by removing excess cholesterol from cells and preventing endothelial dysfunction. Lecithin cholesterol acyltransferase (LCAT plays a central role in the formation and maturation of HDL, and in the intravascular stage of reverse cholesterol transport: a major mechanism by which HDL modulates the development and progression of atherosclerosis. A defect in LCAT function would be expected to enhance atherosclerosis, by interfering with the reverse cholesterol transport step. As such, one would expect to find more atherosclerosis and cardiovascular events in LCAT-deficient patients. But this relationship is not always evident. In this review, we describe contradictory reports in the literature about cardiovascular risks in this patient population. We discuss the paradoxical finding of severe HDL deficiency and an absence of subclinical atherosclerosis in LCAT-deficient patients, which has been used to reject the hypothesis that HDL level is important in the protection against atherosclerosis. Furthermore, to illustrate this paradoxical finding, we present a case study of one patient, referred for evaluation of global cardiovascular risk in the presence of a low HDL cholesterol level, who was diagnosed with LCAT gene mutations.Keywords: atherosclerosis, LCAT function

  12. Ansiedade e parâmetros funcionais respiratórios de idosos praticantes de dança

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    Adriana Coutinho de Azevedo Guimarães

    Full Text Available INTRODUÇÃO: A ansiedade é um diagnóstico comum encontrado em idosos e se associa comumente a anormalidades respiratórias. Ligado ao envelhecimento, encontra-se também o sedentarismo, o qual é um importante fator de risco para diversas patologias. A prática de atividade física regular melhora a ansiedade e a condição cardiorrespiratória. Entre os tipos de atividades físicas, a dança destaca-se como uma boa opção para os idosos. OBJETIVO: Descrever os parâmetros respiratórios de idosas praticantes de dança quando comparadas com idosas sedentárias e a influência da prática regular de dança sobre a ansiedade. MATERIAIS E MÉTODOS: Foram avaliadas 18 idosas, divididas em dois grupos: praticantes de dança (grupo G1 e sedentárias (grupo G2. Nos grupos G1e G2, foram aplicados o inventário de ansiedade traço-estado IDATE, a cirtometria, a espirometria e a manovacuometria, além de ser utilizado o questionário de Baecke modificado para idosos, apenas para o grupo G2, a fim de garantir o sedentarismo dos participantes. Foi realizada a estatística descritiva para sintetizar os dados. RESULTADOS: As participantes do grupo G1 apresentaram valores superiores em relação à ansiedade-estado e à pressão expiratória máxima. A cirtometria em nível basal foi maior nas participantes do grupo G1, enquanto em nível xifoide foi maior nas idosas do grupo G2. Todas as participantes obtiveram valores de espirometria dentro da normalidade, sem diferenças entre os grupos. CONCLUSÃO: Observaram-se nas idosas que praticam dança de forma regular menor nível de ansiedade-traço, valores adequados de pressão expiratória máxima e maior valor na cirtometria em nível basal.

  13. A função da legitimação na governança transnacional

    DEFF Research Database (Denmark)

    Kjær, Poul F.

    2017-01-01

    diferente função e posição das formas nacionais e transnacionais de ordenamento jurídico na sociedade mundial. A tentativa generalizada de analisar desenvolvimentos transnacionais com base em conceitos de lei e de política derivados de contextos de ordenamentos nacionais é, portanto, problemática. Assim...... ser entendidas como equivalentes funcionais da democracia, na medida em que ambas podem ser compreendidas como instrumentos de crescente reflexividade. A diferença central, entretanto, é que contextos legitimados pela democracia implicam uma forma ex ante do político em contraste com a ênfase expost...

  14. O absenteísmo - doença da equipe de enfermagem de um hospital universitário

    OpenAIRE

    Marques, Divina de Oliveira; Pereira, Milca Severino; Souza, Adenícia Custódia Silva e; Vila, Vanessa da Silva Carvalho; Almeida, Carlos Cristiano Oliveira de Faria; Oliveira, Enio Chaves de

    2015-01-01

    RESUMOObjetivo:analisar o absenteísmo-doença da equipe de enfermagem.Método:estudo retrospectivo, com abordagem quantitativa, realizado em um hospital universitário, localizado no município de Goiânia, Goiás, Brasil. Os dados foram coletados nos dossiês funcionais dos trabalhadores referentes ao período de 2008 a 2012.Resultados:dos 602 trabalhadores, 435 apresentaram 1574 atestados médicos. As doenças do sistema osteomuscular e do tecido conjuntivo, seguidas dos transtornos mentais e comport...

  15. Uma nova abordagem organizacional para gestão da cadeia de suprimentos

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    Lino Guimarães Marujo

    2006-01-01

    Full Text Available Este artigo trata da reestruturação organizacional para a gestão da cadeia de suprimentos, como uma ferramenta para o aumento do nível de serviço aos clientes. A partir de um referencial teórico-prático onde uma organização foi observada e assim traçada a forma de gestão de sua cadeia de suprimento. Observa o fenômeno da concorrência baseada no tempo que faz com que as empresas se flexibilizem frente as constantes exigências enfrentadas em seus mercados, além de analisar a transformação dos processos intra-funcionais em inter-funcionais, exigindo que todos os departamentos interajam e promovam um fluxo ininterrupto das informações inerentes aos processos organizacionais alinhados as exigências de mercados globalizados. Dentro destes processos organizacionais se dispõem determinadas tarefas e processos-chave para um gerenciamento da cadeia de suprimentos mais eficaz, abrangendo processos tais quais: a gestão de transportes inbound e outbound, a administração de pedidos de clientes, a gestão de materiais e planejamento de produção, gestão de estoques e processos, além da assistência técnica aos clientes, quando necessário. Por fim é proposta uma nova estrutura para a gestão da cadeia de suprimentos.

  16. Relationship between TG/HDL-C ratio and metabolic syndrome risk factors with chronic kidney disease in healthy adult population.

    Science.gov (United States)

    Ho, Chih-I; Chen, Jau-Yuan; Chen, Shou-Yen; Tsai, Yi-Wen; Weng, Yi-Ming; Tsao, Yu-Chung; Li, Wen-Cheng

    2015-10-01

    The triglycerides-to-high-density lipoprotein-cholesterol (TG/HDL-C) ratio has been identified as a biomarker of insulin resistance and a predictor for atherosclerosis. The objectives of this study were to investigate which the TG/HDL-C ratio is useful to detect metabolic syndrome (MS) risk factors and subclinical chronic kidney disease (CKD) in general population without known CKD or renal impairment and to compare predictive accuracy of MS risk factors. This was a cross-sectional study. A total 46,255 subjects aged ≥18 years undergoing health examination during 2010-2011 in Taiwan. The independent associations between TG/HDL-C ratio quartiles, waist circumstance (WC) waist-to-height ratio (WHtR), mean atrial pressure (MAP), and CKD prevalence was analyzed by using logistic regression models. Analyses of the areas under receiver operating characteristic (ROC) were performed to determine the accuracy of MS risk factors in predicting CKD. A dose-response manner was observed for the prevalence of CKD and measurements of MS risk factors, showing increases from the lowest to the highest quartile of the TG/HDL-C ratio. Males and females in the highest TG/HDL-C ratio quartile (>2.76) had a 1.4-fold and 1.74-fold greater risk of CKD than those in the lowest quartile (≤1.04), independent of confounding factors. Mean arterial pressure (MAP) had the highest AUC for predicting CKD among MS risk factors. The TG/HDL-C ratio was an independent risk factor for CKD, but it showed no superiority over MAP in predicting CKD. A TG/HDL-C ratio ≥2.76 may be useful in clinical practice to detect subjects with worsened cardiometabolic profile who need monitoring to prevent CKD. TG/HDL-C ratio is an independent risk factor for CKD in adults aged 18-50 years. MAP was the most powerful predictor over other MS risk factors in predicting CKD. However, longitudinal and comparative studies are required to demonstrate the predictive value of TG/HDL-C on the onset and progression of CKD over

  17. Combining LDL-C and HDL-C to predict survival in late life: The InChianti study.

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    Giovanni Zuliani

    Full Text Available While the relationship between total cholesterol (TC and cardiovascular disease (CVD progressively weakens with aging, several studies have shown that low TC is associated with increased mortality in older individuals. However, the possible additive/synergic contribution of the two most important cholesterol rich fractions (LDL-C and HDL-C to mortality risk has not been previously investigated. Our study aimed to investigate the relationship between baseline LDL-C and HDL-C, both separately and combined, and 9-years mortality in a sample of community dwelling older individuals from the InCHIANTI study.1044 individuals over 64 years were included. CVD and cancer mortality were defined by ICD-9 codes 390-459 and 140-239, respectively. LDL-C <130 mg/dL (3.36 mmol/L was defined as "optimal/near optimal". Low HDL-C was defined as <40/50 mg/dL (1.03/1.29 mmol/L in males/females, respectively. Nine-years mortality risk was calculated by multivariate Cox proportional hazards model. We found that, compared to subjects with high LDL-C and normal HDL-C (reference group, total mortality was significantly increased in subjects with optimal/near optimal LDL-C and low HDL-C (H.R.:1.58; 95%CI:1.11-2.25. As regards the specific cause of death, CVD mortality was not affected by LDL-C/HDL-C levels, while cancer mortality was significantly increased in all subjects with optimal/near optimal LDL-C (with normal HDL-C: H.R.: 2.49; with low HDL-C: H.R.: 4.52. Results were unchanged after exclusion of the first three years of follow-up, and of subjects with low TC (<160 g/dL-4.13 mmol/L.Our findings suggest that, in community dwelling older individuals, the combined presence of optimal/near optimal LDL-C and low HDL-C represents a marker of increased future mortality.

  18. Marrubium vulgare extract inhibits human-LDL oxidation and enhances HDL-mediated cholesterol efflux in THP-1 macrophage.

    Science.gov (United States)

    Berrougui, Hicham; Isabelle, Maxim; Cherki, Mounia; Khalil, Abdelouahed

    2006-12-14

    The objective of the present study was to elucidate the beneficial properties of aqueous extracts of Marrubium vulgare (AEM) towards cardiovascular disease by protecting human-LDL against lipid peroxidation and promoting HDL-mediated cholesterol efflux. Human-LDL were oxidised by incubation with CuSO(4) in the presence of increased concentrations of AEM (0-100 microg/ml). LDL lipid peroxidation was evaluated by conjugated diene formation, vitamin E disappearance as well as LDL-electrophoretic mobility. HDL-mediated cholesterol efflux assay was carried out in human THP-1 macrophages. Incubation of LDL with AEM significantly prolonged the lag phase (P=0.014), lowered the progression rate of lipid peroxidation (P=0.004), reduced the disappearance of vitamin E and the electrophoretic mobility in a dose-dependent manner. Also, incubation of HDL with AEM significantly increased HDL-mediated cholesterol efflux from THP-1 macrophages implicating an independent ATP binding cassette A1 (ABCA1) pathways. Our findings suggest that M. vulgare provides a source of natural antioxidants, which inhibit LDL oxidation and enhance reverse cholesterol transport and thus can prevent cardiovascular diseases development. These antioxidant properties increase the anti-atherogenic potential of HDL.

  19. Impact of Lifestyle Intervention on HDL-Induced eNOS Activation and Cholesterol Efflux Capacity in Obese Adolescent

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    Jenny Wesnigk

    2016-01-01

    Full Text Available Background. Endothelial dysfunction occurs in obese children and adolescent and is regarded as a key step in the development of atherosclerosis. Important components for the development of endothelial dysfunction are reduced activity of endothelial nitric oxide synthase (eNOS and an increase in cholesterol deposition in the vessel wall, due to reduced reverse cholesterol transport (RCT activity. High density lipoprotein (HDL exhibits antiatherosclerotic properties including modulation of eNOS activity and cholesterol efflux capacity. Lifestyle intervention programs can modify endothelial dysfunction in obese adolescents, but their impact on HDL-mediated eNOS activation and RCT is unknown so far. Methods. Obese adolescents (15±1 years, BMI > 35 kg/m2 where randomized either to an intervention group (IG, n=8; restricted diet and exercise or to a usual care group (UC, n=8. At the beginning and after 10 months of treatment HDL-mediated eNOS phosphorylation and cholesterol efflux capacity were evaluated. Results. Ten months of treatment resulted in a substantial weight loss (−31%, an improvement of endothelial function, and an increase in HDL-mediated eNOS-Ser1177 phosphorylation and RCT. A correlation between change in eNOS-Ser1177 phosphorylation or RCT and change in endothelial function was noted. Conclusion. A structured lifestyle intervention program improves antiatherosclerotic HDL functions, thereby positively influencing endothelial function.

  20. Adrenal Function in females with low plasma HDL-C due to mutations in ABCA1 and LCAT.

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    Andrea E Bochem

    Full Text Available INTRODUCTION: Adrenal steroidogenesis is essential for human survival and depends on the availability of the precursor cholesterol. Male subjects with low plasma levels of high density lipoprotein (HDL cholesterol are characterized by decreased adrenal function. Whether this is also the case in female subjects with low plasma HDL-C levels is unresolved to date. FINDINGS: 15 female ATP binding cassette transporter AI (ABCAI and 14 female lecithin-cholesterol acyltransferase (LCAT were included in the study. HDL-C levels were 38% and 41% lower in ABCA1 and LCAT mutation carriers compared to controls, respectively. Urinary steroid excretion of 17-ketogenic steroids or 17-hydroxy corticosteroids did not differ between 15 female ABCA1 mutation carriers (p = 0.27 vs 0.30 respectively and 30 matched normolipidemic controls or between 14 female LCAT mutation carriers and 28 matched normolipidemic controls (p = 0.10 and 0.14, respectively. Cosyntropin testing in an unselected subgroup of 8 ABCA1 mutation carriers and 3 LCAT mutation carriers did not reveal differences between carriers and controls. CONCLUSION: Adrenal function in females with molecularly defined low HDL-C levels is not different from controls. The discrepancy with the finding of impaired steroidogenesis in males with molecularly defined low HDL-C levels underscores the importance of gender specific analyses in cholesterol-related research.

  1. Análise da efetividade da fisioterapia através da psicomotricidade em idosos institucionalizados

    Directory of Open Access Journals (Sweden)

    Sofia Banzatto

    2015-03-01

    Full Text Available Objetivo: Analisar a percepção dos idosos a respeito da efetividade da fisioterapia através de atividades psicomotoras. Métodos: Tratou-se de um estudo de natureza descritiva, com abordagem qualitativa, realizado com 19 idosos, independentemente do sexo, que praticavam atividades psicomotoras regularmente no Lar Torres de Melo, uma instituição filantrópica localizada em Fortaleza-CE. As informações foram coletadas a partir de uma entrevista semiestruturada entre o período de fevereiro a maio de 2013. Após transcrição, leitura e releitura das entrevistas, emergiram as seguintes categorias temáticas: percepção dos benefícios; sensação percebida após as atividades psicomotoras; percebendo a importância da fisioterapia; e contribuição da psicomotricidade para o emocional. Resultados: Pode-se observar nas falas dos idosos que as atividades psicomotoras estabelecem uma melhora na sua qualidade de vida, ajudando-os a manter suas capacidades funcionais com autonomia e independência, criando forças para enfrentar suas limitações e superá-las. Há uma melhora do bem-estar geral, ajuda na preservação do viver independente e minimiza as consequências de certas incapacidades. Os idosos percebem também a importância da fisioterapia para sua capacidade funcional, e que a psicomotricidade contribui para o seu emocional. Conclusão: Os idosos institucionalizados sentem que a psicomotricidade contribui para o emocional deles e que as atividades auxiliam o desempenho físico e mental, melhorando a autonomia e capacidade de enfrentar suas limitações, proporcionando uma melhor condição de vida.

  2. Editorial - A era da nanoescala na Saúde

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    William Waissmann

    2013-11-01

    Full Text Available Há duas décadas, Meirelles elaborou tese de doutoramento em que analisou a miniaturização de instrumentos, a evolução dos processos produtivos humanos e sua associação à redução da ne-cessidade de trabalho socialmente necessário2. Instrumentos menores, mais leves, mais facilmente transportados, com propriedades mais engenhosas e diferenciadas permitiram, progressivamente, maior distanciamento das fontes geradoras de matérias primas. A miniaturização seguiu e induziu parte do curso das transformações produtivas, associando-se a mudanças de propriedades funcionais laborais e sociais. A redução dos instrumentos foi componente importante nos ganhos crescentes de produtividade do trabalho humano ao longo dos séculos.

  3. Non-leaky vesiculation of large unilamellar vesicles (LUV) induced by plasma high density lipoproteins (HDL): Detection by HPLC

    International Nuclear Information System (INIS)

    Tischler, U.; Rueckert, D.S.; Schubert, R.; Jaroni, H.W.; Schmidt, K.H.

    1989-01-01

    Interaction of large unilamellar phosphatidylcholine vesicles (LUV, 75nm) and plasma high density lipoproteins (HDL) resulted in a non-leaky vesiculation of LUV. This vesiculation was detected by a HPLC-system consisting of a combination of three TSK-gel columns (6000PW, 5000PW, 3000SW). With increasing incubation time liposomal [ 14 C]PC, entrapped [ 3 H]inulin, and apoprotein of HDL origin decreased. The decrease was accompanied by a formation of new particles, consisting of liposomal PC and apoprotein. These particles also enclosed [3H]inulin, reflecting a hydrophilic inner space. The formation of the particles reached a maximum after one day of incubation. Retention time was 21 minutes for LUV, 28 minutes for the new particles, and 36 minutes for HDL. In vesicles with membranes consisting of phosphatidylcholine and 30% cholesterol no interactions were observed

  4. Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats

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    Neves Valdir A

    2011-09-01

    Full Text Available Abstract Background This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin, in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals. Methods Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9: 1 standard (STD: fed on casein as protein source; 2 hypercholesterolemic (HC: STD plus 1% cholesterol and 0.5% cholic acid; 3 HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day; 4 HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day; 5 HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3 and (4. The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain. Results A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet. Conclusion Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin and the protein (glycinin were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism.

  5. Plasma kinetics of an LDL-like nanoemulsion and lipid transfer to HDL in subjects with glucose intolerance

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    Marina P Bertato

    2012-01-01

    Full Text Available OBJECTIVE: Glucose intolerance is frequently associated with an altered plasma lipid profile and increased cardiovascular disease risk. Nonetheless, lipid metabolism is scarcely studied in normolipidemic glucose-intolerant patients. The aim of this study was to investigate whether important lipid metabolic parameters, such as the kinetics of LDL free and esterified cholesterol and the transfer of lipids to HDL, are altered in glucose-intolerant patients with normal plasma lipids. METHODS: Fourteen glucose-intolerant patients and 15 control patients were studied; none of the patients had cardiovascular disease manifestations, and they were paired for age, sex, race and co-morbidities. A nanoemulsion resembling a LDL lipid composition (LDE labeled with 14C-cholesteryl ester and ³H-free cholesterol was intravenously injected, and blood samples were collected over a 24-h period to determine the fractional clearance rate of the labels by compartmental analysis. The transfer of free and esterified cholesterol, triglycerides and phospholipids from the LDE to HDL was measured by the incubation of the LDE with plasma and radioactivity counting of the supernatant after chemical precipitation of non-HDL fractions. RESULTS: The levels of LDL, non-HDL and HDL cholesterol, triglycerides, apo A1 and apo B were equal in both groups. The 14C-esterified cholesterol fractional clearance rate was not different between glucose-intolerant and control patients, but the ³H-free-cholesterol fractional clearance rate was greater in glucose-intolerant patients than in control patients. The lipid transfer to HDL was equal in both groups. CONCLUSION: In these glucose-intolerant patients with normal plasma lipids, a faster removal of LDE free cholesterol was the only lipid metabolic alteration detected in our study. This finding suggests that the dissociation of free cholesterol from lipoprotein particles occurs in normolipidemic glucose intolerance and may participate in

  6. Difference in effect of myristic and stearic acid on plasma HDL cholesterol within 24 h in young men.

    Science.gov (United States)

    Tholstrup, T; Vessby, B; Sandstrom, B

    2003-06-01

    There is increasing evidence that postprandial triacylglycerol (TAG)-rich lipoproteins (TRL) may be related to atherogenic risk. Little is known about the acute effect of individual dietary saturated fatty acids on plasma lipids and lipoproteins. To investigate the effect of two prevalent dietary saturated fatty acids, stearic and myristic acid on postprandial and 24 h fasting plasma lipoprotein TAG and cholesterol concentrations. Ten young healthy men were served two meals (1.2 g fat/kg body weight) containing fat enriched in either stearic acid (S) (shea butter) or myristic acid (M) (produced by inter-esterification) in a randomised, cross-over study. The meals were given in the morning after 12 h of fasting and again after 8 h (in the afternoon). The S and M containing meals were given at different days separated by a washout period. Blood samples were taken before the meal and 2,4,6,8, and 24 h after the first meal. The M meal resulted in a higher postprandial HDL TAG response than S (P=0.03 I), (diet x time interaction), while no differences were observed in other lipid fractions. Twenty-four hours after the M meal fasting, HDL cholesterol was higher (P=0.05) and HDL TAG lower (P<0.001) than at baseline. Intake of individual dietary SFA may affect fasting HDL cholesterol within 24 h. Thus after this short period HDL cholesterol concentration was higher after myristic acid than stearic acid. Myristic acid resulted in a higher increase in postprandial HDL TAG than stearic acid.

  7. Analogias no ensino da célula: análise de livros didáticos de Biologia adotados pelo Plano Nacional do Livro Didático 2015 no Brasil

    OpenAIRE

    Medeiros Y Araujo, Carla

    2017-01-01

    A pesquisa analisou o uso de analogias em temas relacionados ao ensino da célula em livros didáticos de Biologia do Programa Nacional do Livro Didático do Ministério da Educação-PNLD (Brasil). As análises foram realizadas por meio dos critérios estabelecidos por Curtis e Reigeluth (1984) e Thiele e Treagust (1994). Como resultado, encontraram-se 269 analogias, sendo mais frequentes as funcionais, com nível de enriquecimento simples e com apresentação verbal. Analogias tradicionais foram encon...

  8. [Effect of healthy diet and physical activity on the level of non-HDL cholesterol in obese subjects without cardiovascular disease and diabetes mellitus].

    Science.gov (United States)

    Móczár, Csaba

    2015-10-18

    Prevention program including lifestyle changes was initiated with the participation of obese and overweight subjects recruited from the practices of 29 family doctors. The aim of the author was to analyse changes of non-HDL-cholesterol levels, especially when triglyceride levels were above 2.26 mmol/l, and when non-HDL cholesterol levels were high in association with low HDL-cholesterol levels in overweight or obese subjects who had no cardiovascular disease and diabetes mellitus. Data obtained from 1192 subjects (424 men and 768 women) before and 12 month after inclusion into the prevention program was analysed. The average level of non-HDL-cholesterol in the whole group of subjects decreased from 4.74 to 4.64 mmol/l, but the change was not significant. However, the average concentration of non-HDL-cholesterol was reduced significantly from 4.87 to 4.4 mmol/l in men, whereas no significant change was detected in women. In cases when triglyceride levels were higher than 2.26 mmol/l, the non-HDL-cholesterol level was reduced by 0.65 mmol/l. In cases when the non-HDL-cholesterol level was high in association with low HDL-cholesterol level, the non-HDL-cholesterol was significantly decreased from 5.22 to 4.48 mmol/l. In addition, in cases when HDL-cholesterol levels were low, the average level of the HDL-cholesterol significantly increased from 0.84 to 1.3 mmol/l. Lifestyle changes decrease the level of atherogenic lipid fractions, particularly in men with high triglyceride levels. Improvement of the atherogenic lipid profile in response to lifestyle changes is related not only to the reduction of atherogenic lipid fractions, but also to the increase of HDL-cholesterol level.

  9. The low-resolution structure of nHDL reconstituted with DMPC with and without cholesterol reveals a mechanism for particle expansion.

    Science.gov (United States)

    Gogonea, Valentin; Gerstenecker, Gary S; Wu, Zhiping; Lee, Xavier; Topbas, Celalettin; Wagner, Matthew A; Tallant, Thomas C; Smith, Jonathan D; Callow, Philip; Pipich, Vitaliy; Malet, Hélène; Schoehn, Guy; DiDonato, Joseph A; Hazen, Stanley L

    2013-04-01

    Small-angle neutron scattering (SANS) with contrast variation was used to obtain the low-resolution structure of nascent HDL (nHDL) reconstituted with dimyristoyl phosphatidylcholine (DMPC) in the absence and presence of cholesterol, [apoA1:DMPC (1:80, mol:mol) and apoA1:DMPC:cholesterol (1:86:9, mol:mol:mol)]. The overall shape of both particles is discoidal with the low-resolution structure of apoA1 visualized as an open, contorted, and out of plane conformation with three arms in nascent HDL/dimyristoyl phosphatidylcholine without cholesterol (nHDL(DMPC)) and two arms in nascent HDL/dimyristoyl phosphatidylcholine with cholesterol (nHDL(DMPC+Chol)). The low-resolution shape of the lipid phase in both nHDL(DMPC) and nHDL(DMPC+Chol) were oblate ellipsoids, and fit well within their respective protein shapes. Modeling studies indicate that apoA1 is folded onto itself in nHDL(DMPC), making a large hairpin, which was also confirmed independently by both cross-linking mass spectrometry and hydrogen-deuterium exchange (HDX) mass spectrometry analyses. In nHDL(DMPC+Chol), the lipid was expanded and no hairpin was visible. Importantly, despite the overall discoidal shape of the whole particle in both nHDL(DMPC) and nHDL(DMPC+Chol), an open conformation (i.e., not a closed belt) of apoA1 is observed. Collectively, these data show that full length apoA1 retains an open architecture that is dictated by its lipid cargo. The lipid is likely predominantly organized as a bilayer with a micelle domain between the open apoA1 arms. The apoA1 configuration observed suggests a mechanism for accommodating changing lipid cargo by quantized expansion of hairpin structures.

  10. Small HDL subclasses become cholesterol-poor during postprandial period after a fat diet intake in subjects with high triglyceridemia increases.

    Science.gov (United States)

    Quintanilla-Cantú, Armando; Peña-de-la-Sancha, Paola; Flores-Castillo, Cristobal; Mejía-Domínguez, Ana María; Posadas-Sánchez, Rosalinda; Pérez-Hernández, Nonanzit; Bautista-Pérez, Rocío; Enriquez-Calderón, Reyna Esmeralda; Juárez-Oropeza, Marco Antonio; Fragoso, José Manuel; Vargas-Alarcón, Gilberto; Pérez-Méndez, Oscar

    2017-01-01

    Postprandial triglyceridemia may transitory affect the structure of HDL subclasses and probably their antiatherogenic properties but little is known in this field. We analyzed the HDL subclasses lipid content along postprandial period. Fifteen metabolic syndrome (MS) patients and 15 healthy controls were enrolled. HDL were isolated from plasma samples obtained at fasting and every 2-h up to 8-h, after a 75-g fat meal. Cholesterol (C), triglycerides (TAG), and phospholipid (Ph) plasma concentrations of five HDL subclasses were determined by densitometry of electrophoresis gels enzymatically stained. The increase of postprandial triglyceridemia expressed as the incremental area under the curve (iAUC) was twice in MS patients than in controls. Only large HDL2b-TAG were higher in MS than controls at 4, 6 and 8h after meal intake, whereas cholesterol of HDL2a, 3a and 3b were lower at 8h. HDL size distribution shifted towards large HDL and HDL3a-, 3b- and 3c-subclasses had a lower content of cholesterol (estimated by the C-to-Ph ratio) in subjects whose iAUC>289.5mgh/dl (n=15) in comparison with those subjects with iAUC below this cutoff point (n=15), independently of the MS status and fasting TAG. Triglycerides content of HDL subclasses changed only discreetly along the postprandial period, whereas paraoxonase-1 remained unchanged. A high postprandial triglyceridemia conditions the shift of HDL size distribution towards large particles and the decrease of cholesterol in HDL3 subclasses. These data demonstrate that postprandial hypertriglyceridemia contributes to a transitory hypoalphalipoproteinemia that may increase the risk of cardiovascular disease. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial.

    Science.gov (United States)

    Farràs, Marta; Fernández-Castillejo, Sara; Rubió, Laura; Arranz, Sara; Catalán, Úrsula; Subirana, Isaac; Romero, Mari-Paz; Castañer, Olga; Pedret, Anna; Blanchart, Gemma; Muñoz-Aguayo, Daniel; Schröder, Helmut; Covas, Maria-Isabel; de la Torre, Rafael; Motilva, Maria-José; Solà, Rosa; Fitó, Montserrat

    2018-01-01

    At present, high-density lipoprotein (HDL) function is thought to be more relevant than HDL cholesterol quantity. Consumption of olive oil phenolic compounds (PCs) has beneficial effects on HDL-related markers. Enriched food with complementary antioxidants could be a suitable option to obtain additional protective effects. Our aim was to ascertain whether virgin olive oils (VOOs) enriched with (a) their own PC (FVOO) and (b) their own PC plus complementary ones from thyme (FVOOT) could improve HDL status and function. Thirty-three hypercholesterolemic individuals ingested (25 ml/day, 3 weeks) (a) VOO (80 ppm), (b) FVOO (500 ppm) and (c) FVOOT (500 ppm) in a randomized, double-blind, controlled, crossover trial. A rise in HDL antioxidant compounds was observed after both functional olive oil interventions. Nevertheless, α-tocopherol, the main HDL antioxidant, was only augmented after FVOOT versus its baseline. In conclusion, long-term consumption of phenol-enriched olive oils induced a better HDL antioxidant content, the complementary phenol-enriched olive oil being the one which increased the main HDL antioxidant, α-tocopherol. Complementary phenol-enriched olive oil could be a useful dietary tool for improving HDL richness in antioxidants. Copyright © 2017. Published by Elsevier Inc.

  12. Isolated low high density lipoprotein-cholesterol (HDL-C: implications of global risk reduction. Case report and systematic scientific review

    Directory of Open Access Journals (Sweden)

    Tyagi Suresh C

    2005-01-01

    Full Text Available Abstract Background The importance of low high-density lipoprotein cholesterol (HDL-C, elevated non HDL-C (as part of the metabolic syndrome, prediabetes, and type 2 diabetes mellitus, and an isolated low HDL-C is rapidly emerging. The antiatherosclerotic roles of reverse cholesterol transport and the pleiotropic antioxidant – anti-inflammatory mechanistic effects of HDL-C are undergoing rapid exponential growth. Case presentation In 1997 a 53-year-old Caucasian male presented with a lipoprotein profile of many years duration with an isolated low HDL-C and uric acid levels in the upper quintile of normal. He developed an acute myocardial infarction involving the right coronary artery and had percutaneous transluminal coronary angioplasty with stenting of this lesion. He also demonstrated a non-critical non-flow limiting lesion of the proximal left anterior descending coronary artery at the time of this evaluation. Following a program of global risk reduction this patient has done well over the past 7 years and remains free of any clinical signs and symptoms of atherosclerosis. His HDL-C and uric acid levels are currently in the normal physiological range. Conclusion Low HDL-C and isolated low HDL-C constitute an important risk factor for atherosclerosis. Therapies that lead to a return to normal physiologic range of HDL-C may result in the delay of atherosclerotic progression.

  13. A Novel Antisense CAG Repeat Transcript at JPH3 Locus Mediating Expanded Polyglutamine Protein Toxicity in Huntington’s Disease-Like 2 (HDL2) Mice

    Science.gov (United States)

    Wilburn, Brian; Rudnicki, Dobrila D.; Zhao, Jing; Weitz, Tara Murphy; Cheng, Yin; Gu, Xiaofeng; Greiner, Erin; Park, Chang Sin; Wang, Nan; Sopher, Bryce L.; La Spada, Albert R.; Osmand, Alex; Margolis, Russell L.; Sun, Yi E.; Yang, X. William

    2011-01-01

    SUMMARY Huntington’s disease like-2 (HDL2) is a phenocopy of Huntington’s disease caused by CTG/CAG repeat expansion at the Junctophilin-3 (JPH3) locus. The mechanisms underlying HDL2 pathogenesis remain unclear. Here we developed a BAC transgenic mouse model of HDL2 (BAC-HDL2) that exhibits progressive motor deficits, selective neurodegenerative pathology and ubiquitin-positive nuclear inclusions (NIs). Molecular analyses reveal a novel promoter at the transgene locus driving the expression of a CAG repeat transcript (HDL2-CAG) from the strand antisense to JPH3, which encodes an expanded polyglutamine (polyQ) protein. Importantly, BAC-HDL2 but not control BAC mice accumulate polyQ-containing NIs in a pattern strikingly similar to those in the patients. Furthermore, BAC mice with genetic silencing of the expanded CUG transcript still express HDL2-CAG transcript and manifest polyQ pathogenesis. Finally, studies of HDL2 mice and patients revealed CBP sequestration into NIs and evidence for interference of CBP-mediated transcriptional activation. These results suggest overlapping polyQ-mediated pathogenic mechanisms in HD and HDL2 PMID:21555070

  14. Modification and Validation of the Triglyceride-to-HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus

    DEFF Research Database (Denmark)

    Paulmichl, Katharina; Hatunic, Mensud; Højlund, Kurt

    2016-01-01

    BACKGROUND: The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings. Insulin, C-peptide, and free fatty acids are components of other insulin-sensitivity indices but thei......BACKGROUND: The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings. Insulin, C-peptide, and free fatty acids are components of other insulin-sensitivity indices...

  15. Influência da fisioterapia no desenvolvimento neuropsicomotor de paciente com hidrocefalia - doi:10.5020/18061230.2009.p199

    Directory of Open Access Journals (Sweden)

    Gabriel Peixoto Leão Almeida

    2012-01-01

    Full Text Available Objetivo: Analisar a influência da fisioterapia no desenvolvimento neuropsicomotor de um paciente com diagnóstico clínico de hidrocefalia. Descrição: Criança, de sexo masculino, 2 anos e 2 meses, com diagnóstico clínico de hidrocefalia e apresentando atraso no desenvolvimento neuropsicomotor. Utilizou-se, nas avaliações, o Sistema de Classificação da Função Motora Grossa (GMFCS e a ficha de Avaliação Sensório-Motora. O período de intervenção durou 20 meses, sendo constatada melhora do Nível IV para o Nível II no GMFSC e melhora das habilidades funcionais e equilíbrio nas posturas do desenvolvimento neuropsicomotor com aquisição da posição bípede e deambulação com apoio ao término da pesquisa. O protocolo de intervenção foi baseado na literatura pertinente e associado com orientações domiciliares e prescrição de órtese suropodálica (AFO. De acordo com os achados do GMFCS e da ficha de Avaliação Sensório-Motora, o paciente obteve evolução a satisfatória e sugere-se que o programa de intervenção proposto, aliado ao desenvolvimento intrínseco da criança, contribuiu para a aquisição de habilidades funcionais. Conclusão: O protocolo utilizado no estudo está de acordo com os dados revistos na literatura, evidenciando a importância dos resultados da presente pesquisa, os quais poderão ser utilizados como referência para futuros estudos.

  16. Functional and morphological changes in the quadriceps muscle induced by eccentric training after ACL reconstruction Alterações funcionais e morfológicas do quadríceps induzidas pelo treinamento excêntrico após reconstrução do LCA

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    Jamilson S. Brasileiro

    2011-08-01

    Full Text Available OBJECTIVES: The purpose of this study was to investigate the contributions of functional and morphological factors in the recovery of the quadriceps muscle after anterior cruciate ligament (ACL reconstruction. METHODS: Nine subjects (31.3±5.8 years underwent eccentric exercise sessions twice a week for 12 weeks. Quadriceps muscle function was evaluated using an isokinetic dynamometer (isometric and eccentric peak torque and electromyography (RMS. Morphological changes were measured using magnetic resonance imaging. RESULTS: The initial evaluation showed a significant deficit in knee extensor torque in the involved limb and significant muscle atrophy along the length of the quadriceps. EMG activity was lower in all tested situations. Eccentric training significantly increased isokinetic torque (from 199±51 to 240±63, pOBJETIVOS: O propósito deste estudo foi avaliar as contribuições dos fatores funcionais e morfológicos na recuperação da força muscular do quadríceps femoral após reconstrução do Ligamento Cruzado Anterior (LCA. MÉTODOS: Nove indivíduos (31,3±5,8 anos foram treinados por meio de contrações excêntricas máximas, duas vezes por semana, durante 12 semanas. A função do quadríceps foi avaliada pela dinamometria isocinética (pico de torque isométrico e excêntrico e pela eletromiografia (EMG. As alterações morfológicas foram mensuradas por meio de ressonância magnética (RNM. Na avaliação inicial, observou-se significativo déficit no torque extensor do joelho do membro acometido, com hipotrofia muscular de todo o quadríceps e redução na atividade EMG, quando comparado ao membro não-acometido. RESULTADOS: O treinamento excêntrico produziu aumento no torque excêntrico a 30º/s (de 199±51 Nm para 240±63 Nm, p<0,05 e no volume muscular, sendo que maiores hipertrofias ocorreram na região proximal da coxa (de 169±27 para 189±25,8 cm², p<0,01. A atividade EMG do Vasto Medial (VM aumentou nas primeiras

  17. Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS

    Science.gov (United States)

    Previous analysis clustered 1,238 individuals from the general population Genetics of Lipid Lowering Drugs Network (GOLDN) study by the size of their fasting very low-density, low-density and high-density lipoproteins (VLDL, LDL, HDL) using latent class analysis. From two of the eight identified gro...

  18. Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk

    DEFF Research Database (Denmark)

    Nordestgaard, Børge G; Tybjærg-Hansen, Anne

    2011-01-01

    To evaluate whether new and known genetic determinants of plasma levels of LDL cholesterol, lipoprotein(a), triglyceride-rich lipoproteins, and HDL cholesterol associate with the risk of cardiovascular disease expected from the effect on lipoprotein levels. Concordance or discordance...

  19. Gender-dependent association of HSD11B1 single nucleotide polymorphisms with glucose and HDL-C levels

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    Luciane Viater Turek

    2014-09-01

    Full Text Available In this study, we investigated the influence of two SNPs (rs846910 and rs12086634 of the HSD11B1 gene that encodes 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1, the enzyme that catalyzes the conversion of cortisol to cortisone, on variables associated with obesity and metabolic syndrome in 215 individuals of both sexes from southern Brazil. The HSD11B1 gene variants were genotyped using the TaqMan SNP genotyping assay. Glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were measured by standard automated methods. Significant results were found in women, with carriers of the G allele of SNP rs12086634 having higher glucose levels than non-carriers. Carriers of the A allele of SNP rs846910 had higher levels of HDL-cholesterol. The involvement of both polymorphisms as independent factors in determining the levels of glucose and HDL-cholesterol was confirmed by multiple regression analysis (β = 0.19 ± 0.09, p = 0.03 and β = 0.22 ± 0.10, p = 0.03, respectively. Our findings suggest that the HSD11B1SNPs studied may indirectly influence glucose and HDL-cholesterol metabolism in women, possibly through down-regulation of the HSD11B1 gene by estrogen.

  20. Effect of theobromine consumption on serum lipoprotein profiles in apparently healthy humans with low HDL-cholesterol concentrations

    NARCIS (Netherlands)

    Jacobs, Doris M.; Smolders, Lotte; Lin, Yuguang; Roo, de Niels; Trautwein, Elke A.; Duynhoven, van John; Mensink, Ronald P.; Plat, Jogchum; Mihaleva, Velitchka V.

    2017-01-01

    Scope: Theobromine is a major active compound in cocoa with allegedly beneficial effect on high-density-lipoprotein-cholesterol (HDL-CH). We have investigated the effect of theobromine (TB) consumption on the concentrations of triglyceride (TG) and cholesterol (CH) in various lipoprotein (LP)

  1. Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe

    NARCIS (Netherlands)

    M.L. Bots (Michiel); D.E. Grobbee (Diederick); P.C. Elwood; Y. Nikitin; J.T. Salonen; A. Freire de Concalves; D. Inzitari; J. Sivenius; V. Benetou (Vassiliki); J. Tuomilehto; P.J. Koudstaal (Peter Jan)

    2002-01-01

    textabstractBACKGROUND: Controversy remains on the relation between serum lipids levels and stroke risk. This paper investigated the association of total and HDL cholesterol level to fatal and non-fatal, and haemorrhagic and ischaemic stroke in four European cohorts participating

  2. Effect of Animal and Industrial Trans Fatty Acids on HDL and LDL Cholesterol Levels in Humans - A Quantitative Review

    NARCIS (Netherlands)

    Brouwer, I.A.; Wanders, A.J.; Katan, M.B.

    2010-01-01

    Background: Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower HDL cholesterol, raise LDL cholesterol, and increase the risk of coronary heart disease. The effects of conjugated linoleic acid

  3. Mutations in the gene for lipoprotein lipase. A cause for low HDL cholesterol levels in individuals heterozygous for familial hypercholesterolemia

    NARCIS (Netherlands)

    Pimstone, S. N.; Gagné, S. E.; Gagné, C.; Lupien, P. J.; Gaudet, D.; Williams, R. R.; Kotze, M.; Reymer, P. W.; Defesche, J. C.; Kastelein, J. J.

    1995-01-01

    Familial hypercholesterolemia (FH) is characterized by elevated plasma concentrations of LDL cholesterol resulting from mutations in the gene for the LDL receptor. Low HDL cholesterol levels are seen frequently in patients both heterozygous and homozygous for mutations in this gene. Suggested

  4. Acometimento da supra-renal associado à paracoccidioidomicose

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    Leonardo Maurício Diniz

    1988-12-01

    Full Text Available A supra-renal foi estudada em 60pacientes com paracoccidioidomicose. Dentre eles, 10(16,7% apresentavam alterações anatômicas ou funcionais das supra-renais. As lesões glandulares associaram-se à paracoccidioidomicose disseminada, com evolução da doença de pelo menos cinco anos sem tratamento e com hipotensão arterial sistêmica. Não houve associação entre alterações anatomoclínicas supra-renais e alterações raáiolôgicaspulmonares. Esses dados revelam a importância da avaliação sistemática da função supra-renal em portadores de formas disseminadas da paracoccidioidomicose.Sixty patients with paracoccidioidomycosis (PCM were studied, with special regard to adrenal involvement. Ten patients (16.7% had adrenal ab-normalities associated with hypotension, a disseminated form of the disease and more than five years of evolution without treatment. No statistical association between adrenal anatomo-clinical alterations and radiological pulmonary abnormalities was observed. These data point out to the importance of systematic evaluation of adrenal function in patients with disseminated PCM.

  5. Desempenho da marcha de idosos praticantes de psicomotricidade

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    Sarah Lins dos Santos

    2014-07-01

    Full Text Available Estudo quase experimental realizado com quinze idosos, desenvolvido na Clínica Escola de Fisioterapia da Universidade Federal da Paraíba, em 2011. Objetivou-se avaliar o desempenho da marcha de idosos praticantes de atividades psicomotoras. Foi realizada uma entrevista estruturada centrada em dados sociais, clínicos e funcionais, com o intuito de poder correlacionar diversas informações que sustentassem o objetivo do estudo. A média no desempenho cognitivo foi de 19,4, na primeira avaliação e de 23,2, na segunda. A média no desempenho de atividades relacionadas à marcha foi de 11,6, na primeira avaliação, e de 15,5, na segunda, logo após a prática de atividades psicomotoras. Constatou-se uma melhora significativa no desempenho das atividades relacionadas à marcha, com irregularidades que persistiram na altura e na continuidade do passo, bem como no desvio da linha média.

  6. Moderate dyslipoproteinemia induced inflammation and remodeling HDL and VLDL particles in post-renal transplant patients

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    Kimak Elzbieta

    2017-06-01

    Full Text Available The aim of this paper was to examine whether moderate dyslipoproteinemia can cause an increase of hsCRP and LPO levels in Tx patients who had received immunosuppressive therapy and were without acute inflammatory diseases. Herein, the lipid levels, hsCRP, LPO, apolipoprotein (apoB, AI, AII, AIInonB, apoB-containing AII (apoB:AII, apoCIII, apoCIIInonB, apoB:CIII, LCAT level, as well as CETP and PON1 activity were determined. All examined Tx patients had moderate dyslipidemia and slightly increased hsCRP, LPO, apoB:AII and apoCIII levels, but decreased LCAT mass, PON1 activity and lipoprotein ratios. Tx patients with apoAI150mg/dl (n=39, but no difference in CETP activity was indicated. Multiple ridge forward regression and Spearman’s correlation test were used. The results of the presented study, show for the first time that higher apoAI/apoB and apoAI/apoCIII ratios induced a decrease of the hsCRP concentration. Moreover, the composition of apoCIIInonB, LDL-C and apoAI brought about an increase of LCAT mass and PON1 activity. In Tx patients with lower concentration of apoAI, an increase of concentration of apoB:AII in VLDL generated a mild oxidation of lipoprotein and an elevated concentration of LPO. However, lower ApoAI/apoB ratio resulted in an increase of PON1 activity and apoB, as well as nonHDL-C levels, and in turn, PON1 activity increased LCAT mass. These disorders rearranged the HDL particle, and, simultaneously, remodeled the VLDL particle. This may prevent antioxidant activity, reverse cholesterol transport and accelerate the rejection of the transplant, as well as bringing about cardiovascular diseases in Tx patients with lower apoAI. Such metabolic pathways can be used as potentially novel targets for pharmacological intervention.

  7. LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression.

    Science.gov (United States)

    Kannisto, Kristina; Gåfvels, Mats; Jiang, Zhao-Yan; Slätis, Katharina; Hu, Xiaoli; Jorns, Carl; Steffensen, Knut R; Eggertsen, Gösta

    2014-01-01

    We investigated whether: (1) liver X receptor (LXR)-driven induction of high-density lipoprotein cholesterol (HDL-C) and other LXR-mediated effects on cholesterol metabolism depend on intestinal cholesterol absorption; and (2) combined treatment with the LXR agonist GW3965 and the cholesterol absorption inhibitor ezetimibe results in synergistic effects on cholesterol metabolism that could be beneficial for treatment of atherosclerosis. Mice were fed 0.2 % cholesterol and treated with GW3965+ezetimibe, GW3965 or ezetimibe. GW3965+ezetimibe treatment elevated serum HDL-C and Apolipoprotein (Apo) AI, effectively reduced the intestinal cholesterol absorption and increased the excretion of faecal neutral sterols. No changes in intestinal ATP-binding cassette (ABC) A1 or ABCG5 protein expression were observed, despite increased mRNA expression, while hepatic ABCA1 was slightly reduced. The combined treatment caused a pronounced down-regulation of intestinal Niemann-Pick C1-like 1 (NPC1L1) and reduced hepatic and intestinal cholesterol levels. GW3965 did not affect the intestinal cholesterol absorption, but increased serum HDL-C and ApoAI levels. GW3965 also increased Apoa1 mRNA levels in primary mouse hepatocytes and HEPA1-6 cells. Ezetimibe reduced the intestinal cholesterol absorption, ABCA1 and ABCG5, but did not affect the serum HDL-C or ApoAI levels. Thus, the LXR-driven induction of HDL-C and ApoAI was independent of the intestinal cholesterol absorption and increased expression of intestinal or hepatic ABCA1 was not required. Inhibited influx of cholesterol via NPC1L1 and/or low levels of intracellular cholesterol prevented post-transcriptional expression of intestinal ABCA1 and ABCG5, despite increased mRNA levels. Combined LXR activation and blocked intestinal cholesterol absorption induced effective faecal elimination of cholesterol.

  8. Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase.

    Science.gov (United States)

    Simic, Branko; Mocharla, Pavani; Crucet, Margot; Osto, Elena; Kratzer, Adelheid; Stivala, Simona; Kühnast, Susan; Speer, Thimoteus; Doycheva, Petia; Princen, Hans M; van der Hoorn, Jose W; Jukema, J Wouter; Giral, Hector; Tailleux, Anne; Landmesser, Ulf; Staels, Bart; Lüscher, Thomas F

    2017-02-01

    High-density lipoprotein cholesterol (HDL-C) is inversely related to cardiovascular risk. HDL-C raising ester transfer protein (CETP) inhibitors, are novel therapeutics. We studied the effects of CETP inhibitors anacetrapib and evacetrapib on triglycerides, cholesterol and lipoproteins, cholesterol efflux, paraoxonase activity (PON-1), reactive oxygen species (ROS), and endothelial function in E3L and E3L.CETP mice. Triglycerides and cholesterol were measured at weeks 5, 14 and 21 in E3L.CETP mice on high cholesterol diet and treated with anacetrapib (3 mg/kg/day), evacetrapib (3 mg/kg/day) or placebo. Cholesterol efflux was assessed ex-vivo in mice treated with CETP inhibitors for 3 weeks on a normal chow diet. Endothelial function was analyzed at week 21 in isolated aortic rings, and serum lipoproteins assessed by fast-performance liquid chromatography. Anacetrapib and evacetrapib increased HDL-C levels (5- and 3.4-fold, resp.) and reduced triglycerides (-39% vs. placebo, p = 0.0174). Total cholesterol levels were reduced only in anacetrapib-treated mice (-32%, p = 0.0386). Cholesterol efflux and PON-1 activity (+45% and +35% vs. control, p < 0.005, resp.) were increased, while aortic ROS production was reduced with evacetrapib (-49% vs. control, p = 0.020). Anacetrapib, but not evacetrapib, impaired endothelium dependent vasorelaxation (p < 0.05). In contrast, no such effects were observed in E3L mice for all parameters tested. Notwithstanding a marked rise in HDL-C, evacetrapib did not improve endothelial function, while anacetrapib impaired it, suggesting that CETP inhibition does not provide vascular protection. Anacetrapib exerts unfavorable endothelial effects beyond CETP inhibition, which may explain the neutral results of large clinical trials in spite of increased HDL-C. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. The relationship between serum ferritin levels and serum lipids and HDL function with respect to age and gender

    Directory of Open Access Journals (Sweden)

    Hamit Yasar Ellidag

    2016-12-01

    Full Text Available Elevated serum ferritin (SFer levels have been associated with chronic diseases such as coronary heart disease and diabetes mellitus type 2. The aim of this study was to examine the relationship between SFer levels and serum lipid parameters, and how this relation changes in terms of age and gender. Additionally, we investigated a possible relationship between SFer levels and high-density lipoprotein (HDL function. SFer levels and lipid panel (total cholesterol (TC, triglyceride (TG, low-density lipoprotein-cholesterol (LDL-C and HDL-C of 4205 people (3139 women, 1066 men were examined retrospectively. Study population was classified according to age and gender. Separately, 100 subjects (52 women, 48 men were randomly recruited to investigate the relation between SFer levels, and HDL dependent paraoxonase-1 (PON1 and arylesterase (ARE activities. In all age groups, women’s SFer levels were found to be significantly lower and HDL-C levels significantly higher compared to men. In the 50-70 ages range, TC and LDL-C levels of women were found to be significantly higher than those of men (P < 0.01. SFer levels tended to increase with age in women. Correlation analyses revealed a negative correlation between levels of SFer and HDL-C, while positive correlations existed between levels of SFer, and TC, TG and LDL-C. There was no significant correlation between SFer levels and PON1 or ARE activities. The finding that increased SFer levels are accompanied by increased serum TC, TG and LDL-C levels may help us to explain the increased risk of metabolic disorders and cardiovascular disease in postmenopausal women.

  10. A Preliminary Verification and Validation (V and V) Methodology for the Artifacts Programmed with a Hardware Description Language (HDL)

    International Nuclear Information System (INIS)

    Suh, Yong Suk; Keum, Jong Yong; Park, Je Youn; Jo, Ki Ho; Jo, Chang Whan

    2008-01-01

    Nowadays, the FPGA (Field Programmable Gate Array) is widely used in various fields of industry. The FPGA was evolved from the technology of PLD (Programmable Logic Device). The FPGA provides more logic gates than the PLD, which integrates millions of programmable logic gates into a chip. It also provides a massive, fast and reliable processing performance. So, we can integrate a system's functions into a FPGA, which can be a SoC (System on Chip). Furthermore, we can make a FPGA-based DSP, which DSP functions are implemented with a FPGA. With these merits, the FPGA is also used in the nuclear industry. For example, the safety-critical I and C component is manufactured with the FPGA. The FPGA is programmed with a HDL. The quality of the artifacts programmed with a HDL can impact on the quality of a FPGA. When a hazard fault exists in the artifact of a FPGA and is activated during its operation, an accident caused by the fault in the FPGA occurs. So, it is necessary to ensure the quality of the artifacts. This paper, for the purpose of applying it to the SMART (System-integrated Modular Advanced ReacTor) MMIS project, is to present a preliminary V and V methodology for HDL programmed artifacts. For this, we reviewed the following items: - Characteristics of HDL programming - Applicable requirements for a HDL program used for the safety-critical systems - Fault modes of a FPGA Based on the review, we establish the preliminary V and V methodology

  11. Present status of the standardization of HDL-C, LDL-C, and TG measurement values available in Japan.

    Science.gov (United States)

    Nakajima, Yasuhito; Yamanishi, Hachiro; Matsuura, Nariaki

    2013-05-01

    Control sera used as evaluation samples in external quality control of HDL-C and LDL-C sometimes show disparities in results between direct methods differing in reaction principles. As a result, the present standardization status is unclear. In 2008, we investigated the present status of standardization of HDL-C, LDL-C, and TG measurement values available in Japan. To evaluate accuracy, refrigerated fresh human serum pools used as samples were analyzed irrespective of the manufacturer's method. To evaluate precision, a questionnaire survey regarding the internal quality control status at each institution was carried out. As evaluation criteria, the permissible limits of error of BA and CVA based on JSCC proposals, and the accuracy and imprecision criterion NCEP proposals were used. There were 70 participating institutions for HDL-C, 65 for LDL-C, and 71 for TG. TG values from the institutions showed 83.1-91.5% for both the JSCC BA range and the NCEP criterion range. HDL-C values within the JSCC BA range were 81.4-82.6% and within the NCEP criterion range the value was 98.6%. Similarly, LDL-C values within the JSCC BA range were 89.2% and within the NCEP criterion range the value were 81.5-83.1%, respectively. Concerning precision, a questionnaire regarding internal quality control of each institution was completed. More than 90% of the institutions showed values within the CVA range proposed by the JSCC for all of HDL-C, LDL-C, and TG. Standardization of lipid assays used for metabolic syndrome-based health checkups has been mostly achieved. © 2013 Wiley Periodicals, Inc.

  12. Análise da função manual na síndrome do túnel do carpo

    OpenAIRE

    Mattos, Daniela Junckes da Silva

    2010-01-01

    Este estudo investigou efeito da Síndrome do Túnel do Carpo (STC) na função manual. Foram analisados os parâmetros da força de preensão e suas associações com as características da STC, bem como o controle da força de preensão de indivíduos com STC em tarefas funcionais e o efeito causado pela fadiga e peso do objeto. Foram avaliadas 13 mulheres com STC (GE) e 13 sem STC (GC) com idade de 43,54 ± 7,70 e 43,23 ± 7,89 anos, respectivamente. O GE foi classificado quando à gravidade dos sintomas ...

  13. Comida reconfortante: a tríade de elementos da sua construção - memória, comunicação e cultura

    OpenAIRE

    Maróstica, Luciana Teixeira

    2014-01-01

    O presente estudo tem como objeto de investigação e análise a tendência gastronômica chamada comfort food. Conhecida por estudiosos de alimentação como comida reconfortante, esta tendência surgiu nos Estados Unidos depois da Segunda Guerra Mundial, mas se popularizou no Brasil a partir de 2006 e é um contraponto ao fast food (comida rápida) e à racionalidade dos alimentos funcionais, dos quais os benefícios à saúde são chamariz. A pesquisa busca identificar o campo de possibilidades para estu...

  14. Caracterização nutricional e funcional da farinha de chia (Salvia hispanica) e sua aplicação no desenvolvimento de pães

    OpenAIRE

    Tânia Rachel Baroni Ferreira

    2013-01-01

    Os alimentos funcionais vêm despertando o interesse de governos, indústrias e principalmente dos consumidores, devido à importância que os mesmos representam para a saúde da população. A semente de chia, um alimento pouco conhecido pela população brasileira, apresenta uma composição nutricional rica em macro e micronutrientes essenciais à saúde humana, podendo auxiliar na prevenção de diversas enfermidades relacionadas ao elevado consumo de gordura saturada e baixa ingestão de fibras. Com bas...

  15. O impacto da implantação dos softwares de ERP - Enterprise Resource Planning - na contabilidade gerencial e no papel do contador gerencial

    OpenAIRE

    Carvalho Filho, Antonio Francisco de

    2010-01-01

    Aborda o impacto da implantação dos sistemas ERP - Enterprise Resource Planning- sobre a Contabilidade e sobre o Papel do Contador Gerencial. Analisa quais foram as alterações estruturais, - funcionais e de responsabilidades ocorridas com a contabilidade gerencial, após a implantação do ERP, bem como as alterações ocorridas no papel do contador gerencial, nas suas funções, na sua importância e no seu papel nas organizações. Identifica, em função desse novo papel, quais são as n...

  16. Aspectos morfológicos e funcionais dos autoimplantes esplênicos em ratos tratados com oxigenio hiperbárico

    Directory of Open Access Journals (Sweden)

    Isabel Cristina Andreatta Lemos Paulo

    Full Text Available OBJETIVO: Estudar aspectos morfológicos e funcionais dos autoimplantes esplênicos de ratos submetidos ou não à oxigenioterapia hiperbárica (OHB. MÉTODOS: Foram estudados em dois períodos distintos 105 ratos Wistar. No período mediato (n= 56 os animais foram avaliados até o 11º dia de pós-operatório, e no período tardio (n= 49, até o 70º dia. Em cada período os ratos foram distribuídos nos grupos: A- Simulação, B- Autoimplante esplênico, tratados com oxigênio hiperbárico ou não. Nos animais do Grupo A realizou-se apenas manipulação do baço. Nos animais do Grupo B realizou-se esplenectomia total e a seguir quatro fragmentos do baço foram implantados no grande omento. Em todos os animais foram dosados os lípides e imunoglobulinas e contadas as plaquetas e os corpúsculos de Howell-Jolly no pré-operatório e no 11º ou 70º dia de pós-operatório. O baço dos animais do Grupo A e os autoimplantes dos animais do Grupo B foram retirados e enviados para avaliação morfológica. RESULTADOS: No grupo B11nt houve aumento do colesterol total, LDL-colesterol, VLDL-colesterol e triglicérides. No grupo B70nt houve aumento do colesterol total e LDL-colesterol. Nos grupos tratados não houve alterações lipídicas. A IgM caiu nos grupos B e não alterou nos grupos A. Os corpúsculos de Howell - Jolly foram menos freqüentes nos grupos Bt que nos grupos Bnt. As plaquetas aumentaram nos grupos B11t e B11nt e não se alteraram nos demais grupos. A viabilidade microscópica dos grupos Bt foi melhor que a dos grupos Bnt. CONCLUSÃO: Os autoimplantes esplênicos dos animais tratados com OHB apresentaram melhor função e viabilidade do que os autoimplantes dos animais não tratados.

  17. Fatores associados às limitações funcionais em idosas de baixa renda Factors associated to functional limitations in elderly of low income

    Directory of Open Access Journals (Sweden)

    Jair Sindra Virtuoso Júnior

    2008-10-01

    Full Text Available OBJETIVO: Analisar a relação dos aspectos sociodemográficos e referentes às condições de saúde com as limitações funcionais em mulheres idosas de baixa renda do Nordeste brasileiro. MÉTODOS: Estudo com delineamento transversal, tendo uma amostra representativa de 208 mulheres, com média de 70 anos (± 7,1 pertencentes a grupos de convivência e que eram residentes na zona urbana do município de Jequié/Bahia. Foi realizada uma bateria de testes físicos, coletadas medidas antropométricas e a aplicação de uma entrevista contendo questões relativas às variáveis sociodemográficas, condições clínicas, saúde percebida, condições físicas e comportamentais. A análise estatística foi realizada com nível de significância pOBJECTIVE: To analyze the relationship of the partner-demographic and relevant aspects to the conditions of health, with the functional limitations in elderly women of low income in the Brazilian Northeast. METHODS: This cross-sectional study involved a representative sample of 208 women with mean age of 70 years (± 7.1, belonging to coexistence groups and that were resident in the urban zone of the municipal district of Jequié / Bahia. A battery of physical tests was conducted, anthropometric measurements were collected and an interview was made concerning subjects related to partner-demographic variables, clinical conditions and apparent health, physical conditions and behavior. The statistical analysis was carried out with a level of significance of p<0.05. Calculation was made of the respective odds ratio by regression binary logistics for analysis of hierarchically clustered factors. RESULTS: Prevalence of functional limitations of the moderate or serious type was 56%. After hierarchical multivariate analysis, significant association was verified with the older age group of 80 years (p=0.02 , conditions of widowhood (p=0.04, presence of arterial hypertension (p=0.001, and physical inactivity at

  18. PERFORMANCE EVALUATION OF sUAS EQUIPPED WITH VELODYNE HDL-32E LiDAR SENSOR

    Directory of Open Access Journals (Sweden)

    G. Jozkow

    2017-08-01

    Full Text Available The Velodyne HDL-32E laser scanner is used more frequently as main mapping sensor in small commercial UASs. However, there is still little information about the actual accuracy of point clouds collected with such UASs. This work evaluates empirically the accuracy of the point cloud collected with such UAS. Accuracy assessment was conducted in four aspects: impact of sensors on theoretical point cloud accuracy, trajectory reconstruction quality, and internal and absolute point cloud accuracies. Theoretical point cloud accuracy was evaluated by calculating 3D position error knowing errors of used sensors. The quality of trajectory reconstruction was assessed by comparing position and attitude differences from forward and reverse EKF solution. Internal and absolute accuracies were evaluated by fitting planes to 8 point cloud samples extracted for planar surfaces. In addition, the absolute accuracy was also determined by calculating point 3D distances between LiDAR UAS and reference TLS point clouds. Test data consisted of point clouds collected in two separate flights performed over the same area. Executed experiments showed that in tested UAS, the trajectory reconstruction, especially attitude, has significant impact on point cloud accuracy. Estimated absolute accuracy of point clouds collected during both test flights was better than 10 cm, thus investigated UAS fits mapping-grade category.

  19. Performance Evaluation of sUAS Equipped with Velodyne HDL-32E LiDAR Sensor

    Science.gov (United States)

    Jozkow, G.; Wieczorek, P.; Karpina, M.; Walicka, A.; Borkowski, A.

    2017-08-01

    The Velodyne HDL-32E laser scanner is used more frequently as main mapping sensor in small commercial UASs. However, there is still little information about the actual accuracy of point clouds collected with such UASs. This work evaluates empirically the accuracy of the point cloud collected with such UAS. Accuracy assessment was conducted in four aspects: impact of sensors on theoretical point cloud accuracy, trajectory reconstruction quality, and internal and absolute point cloud accuracies. Theoretical point cloud accuracy was evaluated by calculating 3D position error knowing errors of used sensors. The quality of trajectory reconstruction was assessed by comparing position and attitude differences from forward and reverse EKF solution. Internal and absolute accuracies were evaluated by fitting planes to 8 point cloud samples extracted for planar surfaces. In addition, the absolute accuracy was also determined by calculating point 3D distances between LiDAR UAS and reference TLS point clouds. Test data consisted of point clouds collected in two separate flights performed over the same area. Executed experiments showed that in tested UAS, the trajectory reconstruction, especially attitude, has significant impact on point cloud accuracy. Estimated absolute accuracy of point clouds collected during both test flights was better than 10 cm, thus investigated UAS fits mapping-grade category.

  20. Pre-heparin lipoprotein lipase mass as a potential mediator in the association between adiponectin and HDL-cholesterol in type 2 diabetes.

    Science.gov (United States)

    Maser, Raelene E; Lenhard, M James; Pohlig, Ryan T; Balagopal, P Babu

    2017-03-01

    Lipoprotein lipase (LPL) is a major enzyme in lipid metabolism. Dyslipidemia, characterized by decreased high-density lipoprotein cholesterol (HDL-C), is prevalent in persons with type 2 diabetes mellitus (T2DM). The aim of this study was to determine whether pre-heparin LPL mass mediates the association between adiponectin and HDL-C in individuals with T2DM. Pre-heparin LPL mass was measured via an enzyme-linked immunosorbent assay, adiponectin by radioimmunoassay, and HDL-C was determined enzymatically. Participants' (n = 50) demographics, HbA1c, adiposity, homeostasis model assessment for insulin resistance (HOMA-IR), serum creatinine, and lipids were measured. Path analysis was utilized to test whether pre-heparin LPL mass is a mediator in the relationship between adiponectin and HDL-C. All four criteria for mediation were satisfied in the path analysis. The indirect effect of adiponectin on HDL-C through pre-heparin LPL mass was significant, p = 0.001, whereas the direct effect of adiponectin on HDL-C was not significant, p = 0.074. These results remained consistent even after adjustments for age, gender, body mass index, HOMA-IR, and serum creatinine in the model. The findings in this study suggest that pre-heparin LPL mass may mediate the association between adiponectin and HDL-C in T2DM. This relationship for measures of HDL-C functionality requires future investigation.

  1. Comparison between Gradient Gel Electrophoresis and Nuclear Magnetic Resonance Spectroscopy in Estimating Coronary Heart Disease Risk Associated with LDL and HDL Particle Size

    NARCIS (Netherlands)

    Arsenault, Benoit J.; Lemieux, Isabelle; Després, Jean-Pierre; Wareham, Nicholas J.; Stroes, Erik S. G.; Kastelein, John J. P.; Khaw, Kay-Tee; Boekholdt, S. Matthijs

    2010-01-01

    BACKGROUND: Gradient gel electrophoresis (GGE) and nuclear magnetic resonance (NMR) spectroscopy are both widely accepted methods for measuring LDL and HDL particle size. However, whether or not GGE- or NMR-measured LDL or HDL particle size predicts coronary heart disease (CHD) risk to a similar

  2. HDL cholesterol response to GH replacement is associated with common cholesteryl ester transfer protein gene variation (-629C>A) and modified by glucocorticoid treatment

    NARCIS (Netherlands)

    Dullaart, Robin P. F.; van den Berg, Gerrit; van der Knaap, Aafke M.; Dijck-Brouwer, Janneke; Dallinga-Thie, Geesje M.; Zelissen, Peter M. J.; Sluiter, Wim J.; van Beek, André P.

    2010-01-01

    GH replacement lowers total cholesterol and low-density lipoprotein cholesterol (LDL-C) in GH-deficient adults, but effects on high-density lipoprotein (HDL) cholesterol (HDL-C) are variable. Both GH and glucocorticoids decrease cholesteryl ester transfer protein (CETP) activity, which is important

  3. Lower HDL-C and apolipoprotein A-I are related to higher glomerular filtration rate in subjects without kidney disease

    NARCIS (Netherlands)

    Krikken, Jan A.; Gansevoort, Ron T.; Dullaart, Robin P. F.

    Animal experiments show that the kidney contributes to apolipoprotein (apo) A-I catabolism. We tested relationships of HDL cholesterol (HDL-C) and apo-I with kidney function in subjects without severe chronic kidney disease. Included was a random sample of the general population (part of the PREVEND

  4. Will Lipidation of ApoA1 through Interaction with ABCA1 at the Intestinal Level Affect the Protective Functions of HDL?

    Directory of Open Access Journals (Sweden)

    Eric J. Niesor

    2015-01-01

    Full Text Available The relationship between levels of high-density lipoprotein cholesterol (HDL-C and cardiovascular (CV risk is well recognized; however, in recent years, large-scale phase III studies with HDL-C-raising or -mimicking agents have failed to demonstrate a clinical benefit on CV outcomes associated with raising HDL-C, casting doubt on the “HDL hypothesis.” This article reviews potential reasons for the observed negative findings with these pharmaceutical compounds, focusing on the paucity of translational models and relevant biomarkers related to HDL metabolism that may have confounded understanding of in vivo mechanisms. A unique function of HDL is its ability to interact with the ATP-binding cassette transporter (ABC A1 via apolipoprotein (Apo A1. Only recently, studies have shown that this process may be involved in the intestinal uptake of dietary sterols and antioxidants (vitamin E, lutein and zeaxanthin at the basolateral surface of enterocytes. This parameter should be assessed for HDL-raising drugs in addition to the more documented reverse cholesterol transport (RCT from peripheral tissues to the liver. Indeed, a single mechanism involving the same interaction between ApoA1 and ABCA1 may encompass two HDL functions previously considered as separate: antioxidant through the intestinal uptake of antioxidants and RCT through cholesterol efflux from loaded cells such as macrophages.

  5. Mortality among patients with non-affective functional psychoses in a metropolitan area of South-Eastern Brazil Mortalidade em pacientes com psicoses funcionais não afetivas na cidade de São Paulo, Brasil

    Directory of Open Access Journals (Sweden)

    Paulo R. Menezes

    1996-08-01

    -se estudo prospectivo no município de São Paulo, SP (Brasil. A amostra consistiu de 120 internações consecutivas em uma região delimitada daquele município, na faixa etária de 18 a 44 anos, com diagnóstico clínico de psicose funcional não afetiva. A amostra foi seguida por 2 anos a partir da internação psiquiátrica. Ao término desse período, foi possível estabelecer a evolução de 116 pacientes (96.7%. Sete pacientes faleceram (6% dos 116 que completaram o estudo, sendo que 5 (4.3% cometeram suicídio. Quatro dos casos de suicídio ocorreram durante os primeiros 12 meses após a alta hospitalar. As Razões de Mortalidade padronizadas para idade e sexo (relativos às taxas de mortalidade para a população de São Paulo foram 8.4 para mortalidade geral (intervalo de confiança de 95%: 4.0-15.9 e 317.9 para mortes por suicídio (intervalo de confiança de 95%: 125.2-668.3. Os resultados do presente estudo indicam que as psicoses funcionais não afetivas estão associadas a uma esperança de vida menor que a observada na população geral. Vários países vêm priorizando, já por muitos anos, a atenção psiquiátrica na comunidade. Tanto pacientes e familiares preferem essa alternativa de tratamento ao antigo modelo hospitalocêntrico. No entanto, é necessário que os programas de saúde mental no Brasil forneçam cuidados de saúde adequados aos pacientes que sofrem desses transtornos, particularmente no período que se segue à alta hospitalar, a fim de que se evite ao máximo uma evolução tão desfavorável para os pacientes e seus familiares.

  6. Alteraciones de patrones funcionales en personas con Tuberculosis pulmonar, Villavicencio, Colombia Alterações dos padrões funcionais de pessoas afetadas pela tuberculose pulmonar, Villavicencio, Colómbia Functional patterns alteration in people with pulmonary tuberculosis, Villavicencio, Colombia

    Directory of Open Access Journals (Sweden)

    Luz Helena Aponte Garzón

    2011-07-01

    Full Text Available Objetivo: determinar las alteraciones de patrones funcionales de salud que más frecuentemente se presentan en personas con tuberculosis pulmonar en tratamiento. Metodología: estudio cualitativo, descriptivo, basado en la técnica de análisis de contenido. Durante el segundo semestre de 2009 se valoraron los patrones funcionales de salud de pacientes inscritos en el Programa de Prevención y Control de Tuberculosis de tres instituciones prestadoras de salud de carácter público de Villavicencio, Meta. Resultados y discusión: los patrones más alterados son el patrón de actividad y ejercicio, patrón de nutrición y metabolismo, patrón cognoscitivo perceptual y patrón de autopercepción y autoconcepto. La fatiga y la disnea comprometen los desplazamientos a la institución de salud, la disminución de la energía dificulta mantener un empleo, lo que afecta los ingresos familiares. Hay desconocimiento acerca de aspectos relevantes para el control de la enfermedad. Se presentan manifestaciones de tristeza y aislamiento asociadas a la percepción social negativa de la enfermedad. Conclusiones: el servicio del equipo de salud debe responder a las situaciones complejas de los enfermos, que van más allá de la administración del tratamiento. Enfermería tiene un rol protagónico en la creación de escenarios de cuidado apropiados y en el fomento de la interdisciplinariedad para la atención integral de los enfermos. Se recomienda desarrollar intervenciones individualizadas con guías de cuidado de enfermería y de manera particular mejorar la información suministrada a las personas acerca de la enfermedad, el tratamiento y las estrategias de prevención y de control de la transmisión.Objetivo: Determinar as alterações dos padrões funcionais da saúde mais freqüentes em pessoas em tratamento contra a tuberculose pulmonar. Metodologia: Estudo qualitativo, descritivo, baseado na técnica de análise de conteúdo. Durante o segundo trimestre

  7. Linfedema: revisão da literatura - doi: 10.5102/ucs.v2i2.539

    Directory of Open Access Journals (Sweden)

    José Roberto P. de Godoy

    2008-04-01

    Full Text Available O linfedema, excesso de líquido intersticial no espaço tecidual, é um dos sinais da insuficiência linfática e ocorre quando a carga linfática ultrapassa o débito linfático, gerando transtornos funcionais, estéticos e psicossociais ao paciente. As infecções e inflamações crônicas no(s membro(s edemaciado(s são fatores que contribuem para redução do transporte e captação do líquido extracelular aumentando progressivamente o linfedema e suas complicações. A Terapia Física Complexa (TFC é a técnica fisioterápica mais eficaz no tratamento, pois age corrigindo as limitações funcionais proporcionando a restauração das atividades da vida diária, a estética e, conseqüentemente, os aspectos psicossociais.

  8. Preparação e avaliação de nanocompósitos de poliestireno - hidróxido duplo lamelar HDL de ZnAl – organofuncionalizado com laurato/palmitato

    Directory of Open Access Journals (Sweden)

    Rodrigo Botan

    2015-02-01

    Full Text Available Este trabalho descreve a síntese e caracterização de nanocompósitos de poliestireno (PS e hidróxido duplo lamelar (HDL formado pelos cátions de ZnAl via polimerização in situ. O HDL utilizado neste trabalho foi modificado com uma mistura de dois ânions, laurato e palmitato. Para caracterização da estrutura e morfologia dos nanocompósitos sintetizados, foram realizadas análises por difração de raios X (DRX e microscopia eletrônica de transmissão (MET. As caracterizações térmicas, mecânicas e de flamabilidade foram realizadas via análise termogravimétrica (TGA, ensaio de flexão e ensaio de flamabilidade, respectivamente. Os resultados obtidos neste trabalho sugerem que os nanocompósitos sintetizados possuem, de uma forma geral, uma morfologia intercalada/esfoliada com melhoras em suas propriedades térmicas e mecânicas, quando comparados com o PS puro. Entretanto, não foi observado melhora na propriedade de flamabilidade.

  9. The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism.

    Science.gov (United States)

    Moradi, Masoumeh; Mahmoudi, Maryam; Saedisomeolia, Ahmad; Zahirihashemi, Roxana; Koohdani, Fariba

    2017-05-25

    People may have different responses to the same environmental changes. It has been reported that genome variations may be responsible for these differences. Also, HDL subfractions may be influenced by different genetic variations. The aim of the present study was to determine gene-diet interactions and to evaluate the influence of weight loss on HDL subfractions between two genotypes of -265 T>C APOA-II polymorphism. In the present study, 56 overweight and obese patients with type 2 diabetes mellitus were selected from 697 genotype-specified subjects. After matching for gender, age and BMI at the beginning of the study, an equal number of patients remained on each genotype of APOA-II (TT/TC and CC group). After a 6-week calorie restriction program, 44 patients completed the study. Serum HDL subfractions, including HDL2 and HDL3 and LCAT activity, were compared between the two genotypes and, before and after the intervention, were separated in each genotype. Serum concentration of HDL and its subfractions decreased significantly due to the weight loss. A comparison of the mean changes between the genotypes showed that HDL3 significantly decreased in the CC genotype while, in the TT/TC group, the serum concentration of HDL2 was significantly reduced. However, the increase of LCAT activity was not significant among the two genotypes. A comparison of mean changes of variables within two genotype groups showed that C homozygote carriers lead to a general shift toward larger size HDL subfractions and T allele carriers shift toward smaller size HDL subfractions after weight loss.

  10. Electromyographic preactivation pattern of the gluteus medius during weight-bearing functional tasks in women with and without anterior knee pain Padrão de pré-ativação eletromiográfica do glúteo médio durante atividades funcionais com descarga de peso em mulheres com e sem dor anterior do joelho

    Directory of Open Access Journals (Sweden)

    Theresa H. Nakagawa

    2011-02-01

    Full Text Available BACKGROUND: Proximal factors have been proposed to influence the biomechanics of the patellofemoral joint. A delayed or diminished gluteus medius (GM activation, before the foot contact on the ground during functional activities could lead to excessive femur adduction and internal rotation and be associated with anterior knee pain (AKP. There are few studies on this topic and the results were inconclusive, therefore, it is necessary to investigate the GM preactivation pattern during functional activities. OBJECTIVE: To compare the GM electromyographic (EMG preactivation pattern during walking, descending stairs and in single leg jump task in women with and without AKP. METHODS: Nine women clinically diagnosed with AKP and ten control subjects with no history of knee injury participated in this study. We evaluated GM EMG linear envelope before the foot contact on the ground during walking and GM onset time and EMG linear envelope during descending stairs as well as in a single leg vertical jump. Mann-Whitney U tests were used to determine the between-group differences in GM EMG preactivation pattern. RESULTS: No between-group differences were observed in GM linear envelope during walking (P=0.41, GM onset time and linear envelope during descending stairs (P=0.17 and P=0.15 and single leg jump (P=0.81 and P=0.33. CONCLUSIONS: Women with AKP did not demonstrated altered GM preactivation pattern during functional weight bearing activities. Our results did not support the hypothesis that poor GM preactivation pattern could be associated with AKP.CONTEXTUALIZAÇÃO: Tem sido proposto que fatores proximais influenciam a biomecânica da articulação fêmoro-patelar. Um atraso ou diminuição da ativação do glúteo médio (GM antes do contato do pé no solo, durante atividades funcionais, poderia levar a adução e rotação interna excessiva do fêmur e provocar a dor anterior do joelho (DAJ. Existem poucos estudos sobre o assunto, e os resultados n

  11. Composition and functional groups of epiedaphic ants (Hymenoptera: Formicidae in irrigated agroecosystem and in nonagricultural areas Composição e grupos funcionais de formigas epiedáficas (Hymenoptera: Formicidae em agroecossistema irrigado e em áreas não agrícolas

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    Patricia Hernández-Ruiz

    2009-08-01

    Full Text Available The objective of this work was to evaluate the species composition and functional groups of ants in nonagricultural (NA and in irrigated areas (S, seasonal irrigation; P, irrigation with well water; W, irrigation with wastewater in an arid agricultural region in central Mexico, throughout 2005 and 2006. A total of 52,358 ants belonging to 6 subfamilies, 21 genera and 39 species was collected using pitfall traps. The species best represented in all plots were: Forelius pruinosus, Pheidole obtusospinosa, Monomorium minimum and Dorymyrmex spp. NA plots recorded the highest density of ants. The highest values for diversity (H' and equitativity (J' were recorded in NA and P plots, while the lowest were recorded in W plots. Cluster analysis showed two different groups regarding species composition: NA-S and W-P. Functional groups recorded were: dominant Dolichoderinae, three species; subordinate Camponotini, five species; hot climate specialists, three species; tropical climate specialists, seven species; cold climate specialists, five species; cryptic species, one species; opportunists, six species; generalized Myrmicinae, nine species. Agricultural activity affects the structure of the ant community with epiedaphic forage, and the constant use of irrigation wastewater in conjunction with intense agricultural practices has negative effect upon species richness of epiedaphic ants.O objetivo deste trabalho foi avaliar a composição de espécies e os grupos funcionais de formigas em áreas não agrícolas (NA e em áreas irrigadas (S, irrigação sazonal; P, irrigação com águas de poço; W, irrigação com água residuária em uma região agrícola de clima árido da região Central do México durante 2005 e 2006. Um total de 52.358 formigas pertencentes a 6 subfamílias, 21 gêneros e 39 espécies foi coletado por meio de armadilhas Pitfall. As espécies mais bem representadas em todas as parcelas foram: Forelius pruinosus, Pheidole obtusospinosa

  12. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL))

    Czech Academy of Sciences Publication Activity Database

    Dobiášová, Milada; Frohlich, J.

    2001-01-01

    Roč. 34, č. 7 (2001), s. 583-588 ISSN 0009-9120. [Congress of the European Atherosclerosis Society /71./. Athens, 26.05.1999-29.05.1999] R&D Projects: GA ČR GV306/96/K220; GA MZd NE5465 Institutional research plan: CEZ:AV0Z5011922 Keywords : atherogenic index of plasma * HDL-cholesterol * triglycerides Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 1.516, year: 2001

  13. Aspectos psicológicos da síndrome da fibromialgia juvenil: revisão de literatura

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    Rubens Goulart

    2016-02-01

    Full Text Available Resumo A síndrome da fibromialgia juvenil (SFJ é uma condição dolorosa não inflamatória crônica que ocorre principalmente em meninas entre nove e 15 anos. Pode ser caracterizada por dores generalizadas e constantes em várias regiões do corpo, distúrbios do sono, fadiga diurna e estado de humor alterado. Fatores psicológicos e biológicos concomitantes resultaram na diminuição da capacidade de lidar com a dor. A qualidade de vida das crianças que sofrem de dores crônicas, e a de seus cuidadores, é severamente prejudicada e a ocorrência de sintomas de ansiedade e depressão é mais comum nessa população. Este estudo objetivou fazer uma revisão sistemática da literatura dos fatores psicossociais relacionados com a SFJ. Os achados revelam uma percepção divergente entre pacientes e parentes em relação aos efeitos da condição. As mães dos pacientes tendem a classificar a doença com uma gravidade maior do que os próprios pacientes. Os pacientes com fibromialgia parecem compartilhar os mesmos traços de personalidade e parece existir um tipo de ambiente familiar favorável à ocorrência da doença. As implicações psicológicas e funcionais devem ser tratadas com métodos que ajudem pacientes e parentes a modificar suas estratégias de enfrentamento dos problemas cotidianos, a aliviar as consequências disfuncionais da dor e da fadiga e a diminuir o risco de catastrofização.

  14. Biblioteca, luta de classes e o posicionamento da Biblioteconomia brasileira: algumas considerações

    Directory of Open Access Journals (Sweden)

    Jonathas Luiz Carvalho Silva

    2010-12-01

    Full Text Available Aborda o processo de identificação e atuação das bibliotecas considerando o contexto da luta de classes e o posicionamento da Biblioteconomia com relação a estes dois fatores. Como condição problematizadora do presente trabalho tem-se as seguintes perguntas: como a biblioteca tem atuado em seu contexto político, social, educativo, cultural, pedagógico e administrativo? Como a Biblioteconomia tem se posicionado diante da atuação das bibliotecas e do conflito da luta de classes? Analisa a biblioteca estabelecendo suas condições funcionais e institucionais, suas divisões em público e privada, o procedimento de como identificar e caracterizar efetivamente uma biblioteca. Avalia o comportamento da biblioteca no que se refere a luta de classes, mostrando que a biblioteca tem servido como um aparelho ideológico do Estado (AIE reproduzindo informações da ideologia dominante relegando a maioria da população a um plano inferior. Analisa ainda o posicionamento da Biblioteconomia brasileira considerando seus três principais expoentes: o curso de nível superior, o profissional e os órgãos de classes considerando as possibilidades de projeções extensionistas da formação acadêmica, de uma mobilização política dos órgãos de classe, visando estimular o profissional a desenvolver uma atividade social fundamentada no processo de atrair não-usuários e inseri-los no espaço da biblioteca através da dinamização do acervo com atividades diversas que estão para além da utilização apenas do livro.

  15. Estudos funcionais de genes envolvidos na manutenção da estabilidade genômica : caracterização de gene hHC1 humano e da DNA polimerqase -PAK de Trypanosoma cruzi.

    OpenAIRE

    Debora de Oliveira Lopes

    2007-01-01

    As células dispõem de diversos sistemas para proteger o material genético dos danos causados por agentes ambientais ou por produtos provenientes do próprio metabolismo. Entre esses sistemas, encontramos o reparo de DNA, constituído por diferentes proteínas que atuam em diversas vias enzimáticas, de acordo com o tipo de lesão gerada. Cada vez torna-se mais evidente a importância de estudos envolvendo fatores associados a sistemas que protegem o material genético, a fim de evitar doenças gen...

  16. Pemberian Teh Kombucha Pada Air Minum Terhadap Nilai Ldl Kolesterol Dan Hdl Kolesterol Darah Ayam Broiler (Gallus SP)

    OpenAIRE

    Djaelani, Muhammad Anwar; Tana, Silvana

    2015-01-01

    The risk of consuming large quantities of food containing cholesterol has been widely known. By knowing the cholesterol content of food products, people could restrict their consumption of high cholesterol food. This study was to knew LDL cholesterol and HDL cholesterol of blood broiler chickens after treated with kombucha tea. This research used the CP 707 broiler strains chickens aged 1 week, treated with kombucha tea that has been fermented for 12 days at a temperature of 25oC. 20 broiler ...

  17. Triglyceride/HDL ratio as a screening tool for predicting success at reducing anti-diabetic medications following weight loss.

    Science.gov (United States)

    Palamaner Subash Shantha, Ghanshyam; Kumar, Anita Ashok; Kahan, Scott; Irukulla, Pavan Kumar; Cheskin, Lawrence Jay

    2013-01-01

    Intentional weight loss, by reducing insulin resistance, results in both better glycemic control and decreased need for anti-diabetic medications. However, not everyone who is successful with weight loss is able to reduce anti-diabetic medication use. In this retrospective cohort study, we assessed the predictive accuracy of baseline triglyceride (TGL)/HDL ratio, a marker of insulin resistance, to screen patients for success in reducing anti-diabetic medication use with weight loss. Case records of 121 overweight and obese attendees at two outpatient weight management centers were analyzed. The weight loss intervention consisted of a calorie-restricted diet (~1000Kcal/day deficit), a behavior modification plan, and a plan for increasing physical activity. Mean period of follow-up was 12.5 ± 3.5 months. By study exit, mean weight loss and mean HbA1c% reduction were 15.4 ± 5.5 kgs and 0.5 ± 0.2% respectively. 81 (67%) in the study cohort achieved at least 1 dose reduction of any anti-diabetic medication. Tests for predictive accuracy of baseline TGL/HDL ratio ≤ 3 to determine success with dose reductions of anti-diabetic medications showed a sensitivity, specificity, positive predictive value, negative predictive value, area under the curve, likelihood ratio (LR) + and LR-of 81, 83, 90, 70, 78, 4.8 and 0.2, respectively. Reproducibility of TGL/HDL ratio was acceptable. TGL/HDL ratio shows promise as an effective screening tool to determine success with dose reductions of anti-diabetic medications. The results of our study may inform the conduct of a systematic review using data from prior weight loss trials.

  18. Interação comportamento de pastejo´dinâmica de tipos funcionais em pastagem natural na depressão central do Rio Grande do Sul Interaction between grazing behavior and functional type dynamics in native grassland in the central depression Region of Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Betina Raquel Cunha dos Santos

    2006-10-01

    Full Text Available Este estudo foi realizado com o objetivo de avaliar os comportamentos alimentar e espacial de bovinos em pastejo em função da dinâmica de tipos funcionais (TF em pastagem natural, definidos por meio da descrição de atributos morfológicos. Foram utilizadas novilhas em pastejo rotacionado, com oferta média de forragem de 12% (12 kg de MS/100 kg PV. O ritmo de atividade dos animais foi acompanhado durante o período de 12/02 a 27/02/2003 utilizando-se registradores automáticos Ethosys. Para a medição dos atributos, foram marcadas 30 unidades amostrais permanentes, compostas de cinco quadros contíguos de 0,20 x 0,20 m. Os resultados da descrição da comunidade indicaram um subconjunto ótimo de dois atributos (biomassa superior e biomassa lenhosa, os quais definiram oito TF, indicando congruência de 0,43 com a variável ambiental graus-dia. A evolução dos tempos de pastejo comprovou que, à medida que diminuem os TF preferidos, ocorre aumento nos tempos de pastejo. A caracterização da vegetação com base na definição de atributos, em comparação àquela realizada somente pela identificação das espécies presentes na área, facilitou a compreensão da resposta interativa vegetação ´ animal. Simultaneamente, à medida que a vegetação se alterou, os animais modularam seu comportamento ajustando seus ritmos de atividade, no tempo e no espaço, provocando continuamente impactos diferenciais na vegetação, que evolui com o tempo.This study aimed to describe the feeding and spatial behavior of beef heifers under rotational stocking, in response to the dynamics of the morphological functional types (TFs in natural grassland. Stocking rate was adjusted to keep an average of 12% (12 kg DM/100 kg BW of forage allowance. Animal activity was registered from 12 to 27 February 2003 using the Ethosys automatic device. Thirty permanent field sampling units comprised by five adjacent 0.20 x 0.20 m squares were used to determine pasture

  19. Is non-HDL-cholesterol a better predictor of long-term outcome in patients after acute myocardial infarction compared to LDL-cholesterol? : a retrospective study.

    Science.gov (United States)

    Wongcharoen, Wanwarang; Sutthiwutthichai, Satjatham; Gunaparn, Siriluck; Phrommintikul, Arintaya

    2017-01-05

    It has recently been shown that non-high density lipoprotein cholesterol (non-HDL-C) may be a better predictor of cardiovascular risk than low density lipoprotein cholesterol (LDL-C). Based on known ethic differences in lipid parameters and cardiovascular risk prediction, we sought to study the predictability of attaining non-HDL-C target and long-term major adverse cardiovascular event (MACE) in Thai patients after acute myocardial infarction (AMI) compared to attaining LDL-C target. We retrospectively obtained the data of all patients who were admitted at Maharaj Nakorn Chiang Mai hospital due to AMI during 2006-2013. The mean non-HDL-C and LDL-C during long-term follow-up were used to predict MACE at each time point. The patients were classified as target attainment if non-HDL-C LDL-C LDL-C target and 21.2% experienced MACEs. LDL-C and non-HDL-C were directly compared in Cox regression model. Compared with non-HDL-C 130 mg/dl had higher incidence of MACEs (HR 3.15, 95% CI 1.46-6.80, P = 0.003). Surprisingly, LDL-C >100 mg/dl was associated with reduced risk of MACE as compared to LDL LDL-C goal was not associated with the higher risk. Therefore, non-HDL-C may be a more suitable target of dyslipidemia treatment than LDL-C in patients after AMI.

  20. Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin

    Science.gov (United States)

    Kühnast, Susan; van der Tuin, Sam J.L.; van der Hoorn, José W.A.; van Klinken, Jan B.; Simic, Branko; Pieterman, Elsbet; Havekes, Louis M.; Landmesser, Ulf; Lüscher, Thomas F.; Willems van Dijk, Ko; Rensen, Patrick C.N.; Jukema, J. Wouter; Princen, Hans M.G.

    2015-01-01

    Background The residual risk that remains after statin treatment supports the addition of other LDL-C-lowering agents and has stimulated the search for secondary treatment targets. Epidemiological studies propose HDL-C as a possible candidate. Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from atheroprotective HDL to atherogenic (V)LDL. The CETP inhibitor anacetrapib decreases (V)LDL-C by ∼15–40% and increases HDL-C by ∼40–140% in clinical trials. We evaluated the effects of a broad dose range of anacetrapib on atherosclerosis and HDL function, and examined possible additive/synergistic effects of anacetrapib on top of atorvastatin in APOE*3Leiden.CETP mice. Methods and results Mice were fed a diet without or with ascending dosages of anacetrapib (0.03; 0.3; 3; 30 mg/kg/day), atorvastatin (2.4 mg/kg/day) alone or in combination with anacetrapib (0.3 mg/kg/day) for 21 weeks. Anacetrapib dose-dependently reduced CETP activity (−59 to −100%, P < 0.001), thereby decreasing non-HDL-C (−24 to −45%, P < 0.001) and increasing HDL-C (+30 to +86%, P < 0.001). Anacetrapib dose-dependently reduced the atherosclerotic lesion area (−41 to −92%, P < 0.01) and severity, increased plaque stability index and added to the effects of atorvastatin by further decreasing lesion size (−95%, P < 0.001) and severity. Analysis of covariance showed that both anacetrapib (P < 0.05) and non-HDL-C (P < 0.001), but not HDL-C (P = 0.76), independently determined lesion size. Conclusion Anacetrapib dose-dependently reduces atherosclerosis, and adds to the anti-atherogenic effects of atorvastatin, which is mainly ascribed to a reduction in non-HDL-C. In addition, anacetrapib improves lesion stability. PMID:25142968

  1. Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China.

    Science.gov (United States)

    Chen, Qing-Jie; Lai, Hong-Mei; Chen, Bang-Dang; Li, Xiao-Mei; Zhai, Hui; He, Chun-Hui; Pan, Shuo; Luo, Jun-Yi; Gao, Jing; Liu, Fen; Ma, Yi-Tong; Yang, Yi-Ning

    2016-02-19

    Elevated LDL-C/HDL-C ratio has been shown to be a marker of lipid metabolism as well as a good predictor of coronary artery disease (CAD). Thus, the aim of this study was to investigate whether the LDL-C/HDL-C ratio is useful for detecting cardiovascular disease (CVD) risk factors in general healthy Uygur adults in Xinjiang. A total of 4047 Uygur subjects aged ≥35 years were selected from the Cardiovascular Risk Survey (CRS) study which was carried out from October 2007 to March 2010. Anthropometric data, blood pressure, lipid profile and fasting glucose were measured in all participants. The prevalence, sensitivity, specificity and distance on the receiver operating characteristic (ROC) curve of each LDL-C/HDL-C ratio were calculated. The prevalence of high LDL-C and low HDL-C cholesterol was high and positively correlated with higher LDL-C/HDL-C ratio in the Uygur population. In both men and women, we detected a slight apparent trend of high prevalence of hypertension and hypercholesterolemia with higher LDL-C/HDL-C ratio. Our study also demonstrated that the discriminatory power of the LDL-C/HDL-C ratio for CVD risk factors was slightly stronger in men than in women. Analysis of the shortest distance in the ROC curves for hypertension, dyslipidemia, diabetes, or ≥two of these risk factors suggested a LDL-C/HDL-C ratio cutoff of 2.5 for both men and women. The results of this study showed that a LDL-C/HDL-C ratio cut-off of 2.5 might be used as the predictive marker to detect CVD risk factors among Uygur adults in Xinjiang.

  2. Determinantes na funcionalidade de idosos da estratégia saúde da família – revisão integrativa

    Directory of Open Access Journals (Sweden)

    Adriano DRUMMOND

    2012-12-01

    Full Text Available O envelhecimento pode ser acompanhado de alterações funcionais, e a Estratégia Saúde da Família (ESF é um programa que atende a uma grande demanda de idosos da comunidade. Objetivo: descrever quais os fatores determinantes na funcionalidade de idosos atendidos pela ESF. Metodologia: tratase de uma revisão integrativa da literatura, de artigos publicados em três (3 bancos de dados, de 2001 a 2011, de acordo com os descritores idoso, Programa Saúde da Família, aptidão física e funcionalidade. Resultados: fatores intrínsecos como idade avançada, o sexo feminino e apresentar doenças, como diabetes, hipertensão arterial e outras reumáticas e neurológicas, influenciam tanto quanto fatores extrínsecos ou socioeconômicos e demográficos, como o baixo nível de renda e de escolaridade. Conclusão: a dependência funcional variou entre 4,2 a 55%, com vários fatores de influência, os quais devem ser avaliados por cada equipe Saúde da Família para uma proposta de intervenção mais eficaz.

  3. ASPECTOS DA GEOGRAFICIDADE DA ALIMENTAÇÃO NUM BAIRRO URBANO POPULAR: O CASO DO BAIRRO “JARDIM TROPICAL”, MUNICÍPIO DE SERRA – ES

    Directory of Open Access Journals (Sweden)

    Cleberson Prudêncio Saraiva

    2010-01-01

    Full Text Available Estudo da alimentação como uma necessidade humana e um fenômeno social, portador de geograficidade. Análise dessa questão por meio do fluxo de pessoas que vão aos objetos geográficos e vendem alimentos, por intermédio do cultivo dos quintais domiciliares e do consumo de alimentos orgânicos. Definição de totalidade espaçotemporal a partir da construção teórica dos Dois circuitos da economia urbana, de Milton Santos, articulada com a observação da Paisagem e a vivência do Cotidiano, ambas complementadas por uma pesquisa qualitativo-quantitativa na área deste estudo. Conclusão de que, se por um lado, a geograficidade da alimentação baseia-se sobretudoem razões econômicas e funcionais, por outro lado, participam nisso, em menor intensidade, os fatores culturais e afetivos

  4. Effect of simvastatin on anti-oxidation and anti-inflammation properties of HDL in apoE-/-mice

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    Di TIAN

    2013-03-01

    Full Text Available Objectives  To investigate the effect of simvastatin on anti-oxidation and anti-inflammation properties of high density lipoprotein (HDL in apoE-/-mice fed with high-fat diet. Methods  Eighteen 8-week old male C57BL/6J mice as blank control group were fed with normal diet, and thirty 8-week old male apoE-/-mice were fed with high-fat diet. Four weeks later, 6 mice in each group were sacrificed. The remaining 24 apoE-/-mice were randomly divided into two groups (12 each: atherosclerosis group (AS group and simvastatin group, while the remaining 12 C57BL/6J mice served as control group. The mice in both control and AS group were fed with the original diet, and the mice in simvastatin group were fed with the same high-fat diet plus simvastatin 5mg/ (kg.d. At the end of the 8th and 16th week, 6 mice were sacrificed in each group. Serum lipid levels, paraoxonase 1 (PON1 activity (arylesterase activity, serum myeloperoxidase (MPO activity, high-density lipoprotein inflammation index (HII and serum hs-CRP levels were determined. The atherosclerotic lesion formation in the aorta was manifested by oil red O staining. Results  At the end of the 8th week, no difference was found in the levels of serum low density lipoprotein cholesterol (LDL-C and high density lipoprotein cholesterol (HDL-C between simvastatin and AS group. At the end of 16th week, the levels of serum LDL-C decreased significantly (P<0.01 and HDL-C increased significantly (P<0.05 in simvastatin group compared with AS group. At the end of the 8th and 16th week, a significant enhancement of the serum PON1 activity but marked decrease in MPO activity, HII, and serum hs-CRP levels were found in simvastatin group compared with that in AS group. The percentage of plaque area (surface area of plaque/ surface area of whole intima in the aorta was significantly smaller in simvastatin group than that in AS group (P<0.05 or P<0.01. Conclusions In addition to lowering LDL-C and elevating HDL

  5. HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization.

    Science.gov (United States)

    Fan, Qiao; Maranville, Joseph C; Fritsche, Lars; Sim, Xueling; Cheung, Chui Ming Gemmy; Chen, Li Jia; Gorski, Mathias; Yamashiro, Kenji; Ahn, Jeeyun; Laude, Augustinus; Dorajoo, Rajkumar; Lim, Tock Han; Teo, Yik-Ying; Blaustein, Robert O; Yoshimura, Nagahisa; Park, Kyu-Hyung; Pang, Chi Pui; Tai, E Shyong; Khor, Chiea Chuen; Wong, Tien Yin; Runz, Heiko; Cheng, Ching-Yu

    2017-12-01

    Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological studies have yielded conflicting results. We investigated the causal role of plasma lipid levels in AMD in multiethnic populations comprising 16 144 advanced AMD cases and 17 832 controls of European descent, together with 2219 cases and 5275 controls of Asian descent, using Mendelian randomization in three models. Model 1 is a conventional meta-analysis which does not account for pleiotropy of instrumental variable (IV) effects. Model 2 is a univariate, inverse variance weighted regression analysis that accounts for potential unbalanced pleiotropy using MR-Egger method. Finally, Model 3 is a multivariate regression analysis that addresses pleiotropy by MR-Egger method and by adjusting for effects on other lipid traits. A 1 standard deviation (SD) higher HDL-cholesterol level was associated with an odds ratio (OR) for AMD of 1.17 (95% confidence interval: 1.07-1.29) in Europeans (P = 6.88 × 10-4) and of 1.58 (1.24-2.00) in Asians (P = 2.92 × 10-4) in Model 3. The corresponding OR estimates were 1.30 (1.09-1.55) in Europeans (P = 3.18 × 10-3) and 1.42 (1.11-1.80) in Asians (P = 4.42 × 10-3) in Model 1, and 1.21 (1.11-1.31) in Europeans (P = 3.12 × 10-5) and 1.51 (1.20-1.91) in Asians (P = 7.61 × 10-4) in Model 2. Conversely, neither LDL-C (Europeans: OR = 0.96, P = 0.272; Asians: OR = 1.02, P = 0.874; Model 3) nor triglyceride levels (Europeans: OR = 0.91, P = 0.102; Asians: OR = 1.06, P = 0.613) were associated with AMD. We also assessed the association between lipid levels and polypoidal choroidal vasculopathy (PCV) in Asians, a subtype of AMD, and found a similar trend for association of PCV with HDL-C levels. Our study shows that high levels of plasma HDL-C are causally associated with an increased risk for advanced AMD in European and

  6. Envelhecimento e dança: análise da produção científica na Biblioteca Virtual de Saúde

    OpenAIRE

    Witter,Carla; Buriti,Marcelo de Almeida; Silva,Gleice Branco; Nogueira,Renatta Simões; Gama,Eliane Florêncio

    2013-01-01

    O envelhecimento produz perda progressiva das aptidões funcionais e da integração social, e a dança vem contribuir na melhora e/ou manutenção dessas perdas, refletindo positivamente na qualidade de vida dos idosos. Pelo fato de a produção científica ser um processo contínuo que traz a dinâmica da descoberta, contribuindo com a ciência e fortalecendo o ensino e o saber científico, desenvolveu-se esta pesquisa, com o objetivo de realizar uma análise da produção científica sobre a temática dança...

  7. Impacto do exercício físico isolado e combinado com dieta sobre os níveis séricos de HDL, LDL, colesterol total e triglicerídeos Impact of isolated and combined with diet physical exercise on the HDL, LDL, total cholesterol and triglycerides plasma levels

    Directory of Open Access Journals (Sweden)

    Sanmira Fagherazzi

    2008-08-01

    Full Text Available Adequados hábitos alimentares e a prática de exercícios físicos exercem efeito benéfico sobre as dislipidemias. Se associados, podem ainda otimizar as mudanças do perfil lipoprotéico plasmático, sendo, além disso, intervenções de custo moderado quando comparados com tratamentos medicamentosos e dependentes de alta tecnologia. Este estudo tem por objetivo avaliar o impacto do exercício físico isolado e combinado com dieta sobre o perfil lipídico em indivíduos com sobrepeso/obesos. O presente trabalho é do tipo retrospectivo analítico observacional. Nele foi analisada a evolução do perfil lipídico e do peso, por período entre três e seis meses, de 30 indivíduos, divididos em dois grupos: grupo exercício (prática de exercício físico e grupo dieta (prática de exercício físico associada à intervenção nutricional. Foram encontradas reduções estatisticamente significativas no CT (-14,4mg/dl; P = 0,022 e no LDL-c (-20,9mg/dl; P = 0,013 para os componentes do grupo exercício. Tal redução também ocorreu em relação à razão CT/HDL-c (-0,9; P = 0,005 para os componentes do grupo dieta. Foi observada elevação dos níveis de HDL-c, apenas no grupo dieta (+4,2 mg/dl. Nesse mesmo grupo verificou-se diminuição no CT (-8mg/dl e no LDL-c (-9,8mg/dl, bem como redução de peso (-2,6kg, no entanto, tais resultados não foram estatisticamente significativos. Quanto aos níveis de TG, não foi verificada evolução positiva em ambos os grupos. Concluiu-se que o efeito isolado do exercício físico foi mais evidente em relação às variáveis CT e LDL-c. Os TG não sofreram modificações positivas com a prática exclusiva de exercícios físicos ou com sua associação à dieta. Para as variáveis HDL-c e peso, a combinação da dieta com o exercício físico apresentou maiores benefícios.Adequate eating habits and physical exercise have a beneficial effect on dislipidemies. When associated, they might even optimize

  8. EFEITOS DA ADIÇÃO DE SEMENTE DE CHIA (Salvia hispanica) EM SORVETE DE MIRTILO (Vaccinium myrtillus)

    OpenAIRE

    Campidelli, Marina Leopoldina Lamounier; Paulinelli, Helenna Rosa; Magalhães, Maísa Lamounier; Penoni, Nayara; Carlos, Fernanda Gonçalves

    2015-01-01

    Uma estratégia para melhorar a qualidade da alimentação humana é a introdução de alimentos funcionais na dieta. Através de pesquisas é comprovado que estes componentes promovem um efeito fisiológico que vai além do valor nutritivo, contribuindo para a manutenção da saúde, bem-estar e diminuição dos riscos à saúde. Desta maneira, cresce o mercado de nutracêuticos e cada vez mais o consumidor se mostra disposto a adquirir estes produtos o que impulsiona o desenvolvimento de novas opções para o ...

  9. Relación entre paraoxonasa, otros componentes de HDL y estado inflamatorio en hemodiálisis Relation between paraoxonase activity, other HDL components and inflammatory conditions in hemodialyzed patients

    Directory of Open Access Journals (Sweden)

    Ana Inés González

    2010-12-01

    Full Text Available La enfermedad renal crónica (ERC se asocia estrechamente con un estado pro-inflamatorio, aumento de lipoproteínas ricas en triglicéridos y disminución de HDL. La HDL contiene enzimas antioxidantes asociadas como la paraoxonasa (PON, cuya actividad en ERC se encuentra disminuida. Nuestro objetivo fue evaluar la relación entre la actividad de PON, apoA1, colesterol(col-HDL y Proteína C reactiva-altamente sensible (PCR-as como marcador de inflamación en pacientes en hemodiálisis. Se estudiaron n = 42 pacientes; edad, mediana (rango = 50 (25-67 años; sexo M/F = 22/20; antigüedad de hemodiálisis = 4.4 ± 0.5 años; índice de masa corporal (IMC = 23 ± 0.5 kg/m². Se obtuvo una muestra de sangre después de 12 h de ayuno y se determinaron los parámetros clásicos del perfil lipídico, se midieron los valores de apoproteínas A1 y B, PON a través de su actividad arilesterasa y PCR-as, la cual permitió dividir a los pacientes con PCR-as ≤ 1 (bajo riesgo, rango: 0.1 a 1.0 mg/l y > 1 mg/l (moderado y alto riesgo, 1.1 a 10.7 mg/l. Los niveles de triglicéridos, col-LDL y apoB no fueron diferentes entre los grupos. Los pacientes con PCR-as > 1 presentaron menor col-HDL (40 ± 2 mg/dl y apoA1 (118 ± 4 mg/dl que los pacientes con PCR-as ≤ 1 (50 ± 4 y 133 ± 5, respectivamente; p 1: 90.5 ± 24.0 μmol/ml.min que en PCR-as ≤ 1: 105.2 ± 18.0. Consecuentemente, se obtuvieron correlaciones inversas entre apoA1 y PCR-as, r = -0.381 p = 0.013 y entre PON y PCR-as, r = -0.32, p = 0.042. Además, el aumento de PCR-as correlacionó positivamente con el IMC, r = 0.318, p = 0.042. La disminución de col-HDL, apoA1 y PON en los individuos con mayor estado inflamatorio explicaría, en parte, el aumento de riesgo cardiovascular de estos pacientes, dado los efectos antiinflamatorios de la apoA1 y antioxidantes de la PON.Advanced Chronic Renal Disease (CKD is closely associated with a pro-inflammatory condition, with an increase in triglyceride

  10. Avaliação da expressão gênica de colágeno em fibroblastos tratados com extratos de fungos endofíticos

    OpenAIRE

    Araújo, Laíza Magalhães de

    2015-01-01

    O processo de envelhecimento da pele é bastante complexo e pode ser classificado como envelhecimento intrínseco, determinado primordialmente por fatores genéticos, e envelhecimento extrínseco, induzido por fatores como exposição crônica à radiação ultravioleta, consumo excessivo de álcool, tabagismo e fatores nutricionais. A pele envelhecida é caracterizada por alterações morfológicas e funcionais que podem provocar o enrugamento, descamação, ressecamento, anormalidade de pigmentação e câncer...

  11. Efeitos da facilitação neuromuscular proprioceptiva na estabilidade postural e risco de quedas em pacientes com sequela de acidente vascular encefálico: estudo piloto

    OpenAIRE

    Lacerda, Natália Noman de; Gomes, Érika Baptista; Pinheiro, Hudson Azevedo

    2013-01-01

    O controle do tronco é uma habilidade motora básica necessária para executar diversas tarefas funcionais, e é deficiente em pacientes que sofreram acidente vascular encefálico (AVE). Objetivo: Avaliar o efeito do método facilitação neuromuscular proprioceptiva (PNF) na estabilidade postural e risco de quedas em pacientes com sequela de AVE. Metodologia: Foi realizado estudo de intervenção que consistiu em treinamento da estabilidade postural por meio de um protocolo fixo constituído por 5 exe...

  12. Aspectos econômicos e operacionais das viagens da frota pesqueira de Manaus, Amazônia Central Economical and operational aspects of the fishing trips of Manaus fleet, Central Amazonia

    OpenAIRE

    Renato Soares Cardoso; Vandick da Silva Batista; Charles Henry Faria Júnior; Wilson Ramos Martins

    2004-01-01

    A pesca na Amazônia representa uma importante atividade social, econômica e cultural, com desembarque de pescado estimado em 25 mil toneladas por ano, somente no terminal de desembarque de Manaus, porém com poucas avaliações socioeconômicas que são fundamentais para o manejo da atividade. O presente trabalho visou avaliar aspectos funcionais das operações de pesca sob o ponto de vista econômico. As informações foram coletadas por intermédio de questionário estruturado junto aos proprietários ...

  13. The effects of knee extensor eccentric training on functional tests in healthy subjects Os efeitos do treino isocinético excêntrico dos extensores do joelho nos testes funcionais em sujeitos saudáveis

    Directory of Open Access Journals (Sweden)

    Heleodório H. Santos

    2010-08-01

    Full Text Available BACKGROUND: It is well known that eccentric training increases muscle strength and promotes greater neural activation, and therefore has been used in the recovery of knee extensors. The hypothesis of this study was that there would be a strong correlation between knee extensor torque and functional tests. OBJECTIVES: To investigate the relationship between knee extensor peak torque and functional tests of agility (runs and propulsion (hop for distance after short-term isokinetic eccentric training. METHODS: Twenty healthy and active male undergraduate students (age 22.5±2.1 years; height 1.72±0.10 m; weight 67.8±9.5 kg; body mass index: 22.5±2.0 kg/m², with no abnormalities or history of injury of the limbs, performed an isokinetic assessment of the knee extensors and flexors and also functional tests before and after isokinetic training, which consisted of 3 sets of 10 MVECs at 30º/s, with 3 minutes of rest between sets, twice a week for 6 weeks. RESULTS: The eccentric training increased the extensor peak torque (16, 27 and 17%; PCONTEXTUALIZAÇÃO: Sabe-se que o treino excêntrico aumenta a força muscular, promovendo uma maior ativação neural e, portanto, tem sido usado na recuperação do torque extensor. A hipótese deste estudo foi a de que possa existir uma forte correlação entre o torque extensor do joelho e os testes funcionais. OBJETIVOS: Correlacionar o torque extensor do joelho com os testes funcionais de agilidade (corridas e impulsão (saltos em distância após o treino isocinético excêntrico de curta duração. MÉTODOS: Vinte homens universitários, ativos e saudáveis (22,5±2,1 anos; 1,72±0,10 m; 67,8±9,5 kg; IMC 22,5±2,0 kg/m², sem reportar anormalidades ou história de lesão no membro inferior, realizaram avaliação isocinética do torque extensor e flexor do joelho e testes funcionais antes e depois do treino isocinético que consistiu em três séries de 10 CEVM a 30º/s, com 3 minutos de repouso entre as

  14. Teoria de fluxos gradientes para um modelo unidimensional periódico não local e para funcionais dependentes do tempo

    OpenAIRE

    Julio Cesar Valencia Guevara

    2016-01-01

    Resumo: Este trabalho tem por objetivo abordar geometricamente os conceitos do cálculo contextualizado no tempo, começando a partir do primeiro momento em que o conceito de limite torna-se necessário com a resolução dos paradoxos de Zeno, passando pelo método da Exaustão de Eudoxo, utilizado por Arquimedes para o cálculo da área do círculo e da área delimitada por um segmento de parábola. Após este estudo prévio, abordamos o método de Fermat para encontrar máximos e mínimos, a reta tangente a...

  15. Asymptomatic individuals with high HDL-C levels overexpress ABCA1 and ABCG1 and present miR-33a dysregulation in peripheral blood mononuclear cells.

    Science.gov (United States)

    Scherrer, D Z; Zago, V H S; Parra, E S; Avansini, S; Panzoldo, N B; Alexandre, F; Baracat, J; Nakandakare, E R; Quintão, E C R; de Faria, E C

    2015-10-01

    Considering the growing knowledge and perspectives on microRNAs (miRNAs) that control high-density lipoprotein cholesterol (HDL-C) levels and metabolism, this study aimed at evaluating whether hsa-miR-33a and hsa-miR-128a are differentially expressed in peripheral blood mononuclear cells from asymptomatic individuals with low and high HDL-C, as well as at investigating the potential relationships with ATP binding cassete transporter A1 (ABCA1) expression, cholesterol efflux capacity and other parameters related with reverse cholesterol transport. In addition, the associations with cardiovascular risk were investigated by carotid-intima media thickness (cIMT). Asymptomatic volunteers of both genders (n=51) were classified according to HDL-C (mg/dL) in hypoalphalipoproteinemics (hypo, HDL-C ≤3 9), hyperalphalipoproteinemics (hyper, HDL-C ≥ 68) and controls (CTL, HDL-C ≥ 40subgroup of 19 volunteers the cellular cholesterol efflux and HDL composition were determined. Total RNA was extracted from peripheral blood mononuclear cells for relative quantification experiments. Hypo volunteers presented significantly higher levels of triglycerides, VLDL-C and insulin; in addition, HDL size and volume decreased when compared with CTL and hyper. Regarding gene expression analysis, the hyper group presented a decrease of 72% in hsa-miR-33a and higher mRNA expression of ABCA1 and ABCG1 when compared with CTL. No significant differences in hsa-miR-128a expression, cholesterol efflux, cIMT or plaques were found. Further studies are necessary to elucidate the mechanisms underlying the complex miRNA network, regulating cellular cholesterol homeostasis in humans and its clinical repercussions. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Low HDL-C level is associated with the development of intracranial artery stenosis: analysis from the Chinese IntraCranial AtheroSclerosis (CICAS study.

    Directory of Open Access Journals (Sweden)

    Yining Qian

    Full Text Available Intracranial atherosclerotic stenosis (ICAS is an important cause of ischemic stroke worldwide. The role of high-density lipoprotein cholesterol (HDL-C or low-density lipoprotein cholesterol (LDL-C in the development of ICAS remains to be elucidated. In the current study, we investigated the relationship of HDL-C level and the risk of developing ICAS in Chinese patients with acute ischemic stroke.From October 2007 to June 2009, a total of 1,984 consecutive ischemic stroke patients were evaluated for the presence of symptomatic ICAS by magnetic resonance angiography (MRA. Patients were classified into two groups: intracranial steno-occlusion (ICAS group, n = 888 and non-intracranial stenosis (NICAS group, n = 1096. Serum lipid profiles were analyzed and compared between the ICAS and NICAS group.Significantly more patients in ICAS group had low HDL-C level (51.6% than in the NICAS group (42.9%, P<0.001. The observed association remained significant after adjustment for conventional risk factors [(adjusted OR 1.36; 95%CI (1.13-1.63]. Such predictive value of low level HDL-C persisted even when LDL-C was at very low level(<1.8 mmol/L. Patients in the lowest serum HDL-C quartile (<0.96 mmol/L had the highest risk of developing ICAS [adjusted OR 1.52; 95%CI (1.17-1.98] compared to patients in the highest serum HDL-C quartile (≥ 1.32 mmol/L after adjustments for the covariates.Low HDL-C level is strongly associated with the development of ICAS. There was an inverse relationship between the level of HDL-C and the risk of developing ICAS.

  17. Is High Serum LDL/HDL Cholesterol Ratio an Emerging Risk Factor for Sudden Cardiac Death? Findings from the KIHD Study.

    Science.gov (United States)

    Kunutsor, Setor K; Zaccardi, Francesco; Karppi, Jouni; Kurl, Sudhir; Laukkanen, Jari A

    2017-06-01

    Low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c), which are components of total cholesterol, have each been suggested to be linked to the risk of sudden cardiac death (SCD). However, the relationship between LDL-c/HDL-c ratio and the risk of SCD has not been previously investigated. We aimed to assess the associations of LDL-c, HDL-c, and the ratio of LDL-c/HDL-c with the risk of SCD. Serum lipoprotein concentrations were assessed at baseline in the Finnish Kuopio Ischemic Heart Disease prospective cohort study of 2,616 men aged 42-61 years at recruitment. Hazard ratios (HRs) (95% confidence intervals [CI]) were assessed. During a median follow-up of 23.0 years, a total of 228 SCDs occurred. There was no significant evidence of an association of LDL-c or HDL-c with the risk of SCD. In analyses adjusted for age, examination year, body mass index, systolic blood pressure, smoking, alcohol consumption, physical activity, years of education, diabetes, previous myocardial infarction, family history of coronary heart disease, and serum high sensitivity C-reactive protein, there was approximately a two-fold increase in the risk of SCD (HR 1.94, 95% CI 1.21-3.11; p=0.006), comparing the top (>4.22) versus bottom (≤2.30) quintile of serum LDL-c/HDL-c ratio. In this middle-aged male population, LDL-c or HDL-c was not associated with the risk of SCD. However, a high serum LDL-c/HDL-c ratio was found to be independently associated with an increased risk of SCD. Further research is warranted to understand the mechanistic pathways underlying this association.

  18. Plasma triglyceride levels and body mass index values are the most important determinants of prebeta-1 HDL concentrations in patients with various types of primary dyslipidemia.

    Science.gov (United States)

    Tsimihodimos, Vasilis; Gazi, Irene; Filippatos, Theodosios; Kostapanos, Michael; Lagos, Kostantinos; Kostara, Christina; Tellis, Constantinos C; Elisaf, Moses; Tselepis, Alexandros D

    2010-02-01

    Experimental studies have shown that the prebeta-1 subclass of high-density lipoprotein particles (prebeta-1 HDL) may play an important role in the reverse cholesterol transport pathway as the initial acceptors of cellular cholesterol. The aim of the present study was the direct comparison of prebeta-1 HDL values in individuals with various types of primary dyslipidemias. Four hundred and eighty-six unrelated individuals were included in the study. According to their lipid values study participants were subdivided into four groups: control group (n=206), type IIA dyslipidemia group (n=148), type IIB dyslipidemia group (n=49) and type IV dyslipidemia group (n=83). All dyslipidemic patients displayed higher concentrations of prebeta-1 HDL compared to control individuals. However, patients with dyslipidemias characterized by an abnormal catabolism of triglyceride-rich lipoproteins (such as dyslipidemias of type IIB and IV) tend to have higher prebeta-1 HDL values compared to patients with hypercholesterolemia, and this increase is proportional to the degree of hypertriglyceridemia. In addition, patients with metabolic syndrome exhibited significantly higher levels of prebeta-1 HDL compared to individuals that do not fulfill the criteria for the diagnosis of this syndrome. Multiple regression analysis revealed that serum triglyceride concentrations and body mass index (BMI) values were the most important determinants of prebeta-1 HDL levels in our population. All dyslipidemic patients exhibit increased prebeta-1 HDL concentrations as compared to normolipidemic individuals. Whether this increase represents a defensive mechanism against atherosclerosis or it is indicative of impaired maturation of HDL particles and thus of a defective reverse cholesterol transport mechanism remains to be established. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

  19. HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function[S

    Science.gov (United States)

    Berisha, Stela Z.; Brubaker, Greg; Kasumov, Takhar; Hung, Kimberly T.; DiBello, Patricia M.; Huang, Ying; Li, Ling; Willard, Belinda; Pollard, Katherine A.; Nagy, Laura E.; Hazen, Stanley L.; Smith, Jonathan D.

    2015-01-01

    HDL functions are impaired by myeloperoxidase (MPO), which selectively targets and oxidizes human apoA1. We previously found that the 4WF isoform of human apoA1, in which the four tryptophan residues are substituted with phenylalanine, is resistant to MPO-mediated loss of function. The purpose of this study was to generate 4WF apoA1 transgenic mice and compare functional properties of the 4WF and wild-type human apoA1 isoforms in vivo. Male mice had significantly higher plasma apoA1 levels than females for both isoforms of human apoA1, attributed to different production rates. With matched plasma apoA1 levels, 4WF transgenics had a trend for slightly less HDL-cholesterol versus human apoA1 transgenics. While 4WF transgenics had 31% less reverse cholesterol transport (RCT) to the plasma compartment, equivalent RCT to the liver and feces was observed. Plasma from both strains had similar ability to accept cholesterol and facilitate ex vivo cholesterol efflux from macrophages. Furthermore, we observed that 4WF transgenic HDL was partially (∼50%) protected from MPO-mediated loss of function while human apoA1 transgenic HDL lost all ABCA1-dependent cholesterol acceptor activity. In conclusion, the structure and function of HDL from 4WF transgenic mice was not different than HDL derived from human apoA1 transgenic mice. PMID:25561462

  20. ATP binding cassette A1 (ABCA1) mediates microparticle formation during high-density lipoprotein (HDL) biogenesis.

    Science.gov (United States)

    Hafiane, Anouar; Genest, Jacques

    2017-02-01

    Micro-particles (MP) are secreted by various cells. Their biological roles in health and in disease remain unknown. Here we describe formation of MP in the process of ABCA1-dependent cholesterol efflux in different cell types. The ATP-binding cassette transporter, subfamily A, member 1 (ABCA1) is the rate-limiting step in the biogenesis of high-density lipoproteins (HDL). We have found that ABCA1 and apoA-I contribute to the formation of MP. Using cell-based systems with overexpression and selective inactivation of ABCA1, pharmacological blockade and modulation of membrane cholesterol content, we characterized MP release from various cell lines. We studied MP release in BHK cells stably expressing ABCA1 under mifepristone control, human THP-1 macrophages and HepG2 cells without, or with incubation with human apoA-I. ABCA1 mediates the production of MPs containing cholesterol. This was also confirmed in primary human monocyte-derived macrophages (MDMs). Adding apoA-I markedly increases MP release from cells. Inhibition of ABCA1 with probucol or decreasing plasma membrane cholesterol with methyl-β cyclodextrin (CDX) markedly reduced MP release and nascent HDL formation. MPs do not contain apoA-I, but contain flotilin-2, a marker of plasma membrane, and CD63, an exosome marker. MPs exhibit considerable size heterogeneity (50-250 nm). We show that MPs are lipoprotein-sized structures created by the ABCA1 transporter, and contribute approximately 30% of ABCA1-and apoA-I mediated cholesterol efflux. In addition, we found that MPs release from cells consists, in part, of exosomes and depends on the same pathway used for HDL biogenesis. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.

    Directory of Open Access Journals (Sweden)

    Bénédicte M J Merle

    Full Text Available BACKGROUND: Several genes implicated in high-density lipoprotein (HDL metabolism have been reported to be associated with age-related macular degeneration (AMD. Furthermore, HDL transport the two carotenoids, lutein and zeaxanthin, which are highly suspected to play a key-role in the protection against AMD. The objective is to confirm the associations of HDL-related loci with AMD and to assess their associations with plasma lutein and zeaxanthin concentrations. METHODS: Alienor study is a prospective population-based study on nutrition and age-related eye diseases performed in 963 elderly residents of Bordeaux, France. AMD was graded according to the international classification, from non-mydriatic colour retinal photographs. Plasma lutein and zeaxanthin were determined by normal-phase high-performance liquid chromatography. The following polymorphisms were studied: rs493258 and rs10468017 (LIPC, rs3764261 (CETP, rs12678919 (LPL and rs1883025 (ABCA1. RESULTS: After multivariate adjustment, the TT genotype of the LIPC rs493258 variant was significantly associated with a reduced risk for early and late AMD (OR=0.64, 95%CI: 0.41-0.99; p=0.049 and OR=0.26, 95%CI: 0.08-0.85; p=0.03, respectively, and with higher plasma zeaxanthin concentrations (p=0.03, while plasma lipids were not significantly different according to this SNP. Besides, the LPL variant was associated with early AMD (OR=0.67, 95%CI: 0.45-1.00; p=0.05 and both with plasma lipids and plasma lutein (p=0.047. Associations of LIPC rs10468017, CETP and ABCA1 polymorphisms with AMD did not reach statistical significance. CONCLUSION: These findings suggest that LIPC and LPL genes could both modify the risk for AMD and the metabolism of lutein and zeaxanthin.

  2. Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Shu Meguro

    2014-01-01

    Full Text Available Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods. We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n=133, 115 men and 18 women; age 64.7±11.5 years; HbA1c 8.1±1.6%. Plasma level of LL-37 was measured by ELISA. Results. Mean plasma LL-37 level was 71.2±22.3 ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (r=−0.450, P<0.01, triglyceride (r=0.445, P<0.01, and high sensitive C-reactive protein (r=0.316, P<0.01 but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β=−0.411, P<0.01 and high sensitive C-reactive protein (β=0.193, P<0.05. Conclusion. Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.

  3. Association of a cholesteryl ester transfer protein variant (rs1800777) with fat mass, HDL cholesterol levels, and metabolic syndrome.

    Science.gov (United States)

    de Luis, Daniel; Izaola, Olatz; Primo, David; Gomez, Emilia; Lopez, Juan Jose; Ortola, Ana; Aller, Rocio

    2018-04-25

    There is little evidence of the association between CETP SNPs and obesity and/or related metabolic parameters. To analyze the association of the polymorphism rs1800777 of the CETP gene with anthropometric parameters, lipid profile, metabolic syndrome and its components, and adipokine levels in obese subjects without type 2 diabetes mellitus or hypertension. A population of 1005 obese subjects was analyzed. Electrical bioimpedance was performed, and blood pressure, presence of metabolic syndrome, dietary intake, physical activity, and biochemical tests were recorded. Nine hundred and sixty eight patients (96.3%) had the GG genotype, 37 patients the GA genotype (3.7%) (no AA genotype was detected). Fat mass (delta: 4.4±1.1kg; p=0.04), waist circumference (delta: 5.6±2.1cm; p=0.02), and waist to hip ratio (delta: 0.04±0.01cm; p=0.01) were higher in A allele carriers than in non-A allele carriers. HDL cholesterol levels were lower in A allele carriers than in non-A allele carriers (delta: 4.2±1.0mg/dL; p=0.04). In the logistic regression analysis, the GA genotype was associated to an increased risk of central obesity (OR 7.55, 95% CI 1.10-55.70, p=0.02) and low HDL cholesterol levels (OR 2.46, 95% CI 1.23-4.91, p=0.014). The CETP variant at position +82 is associated to lower HDL cholesterol levels, increased fat mass, and central obesity in obese subjects. These results may suggest a potential role of this variant gene in pathophysiology of adipose tissue. Copyright © 2018 SEEN y SED. Publicado por Elsevier España, S.L.U. All rights reserved.

  4. Physical, chemical and functional features of apple starch / Propriedades físicas, químicas e funcionais de amido de maçã

    Directory of Open Access Journals (Sweden)

    Gilvan Wosiacki

    2003-05-01

    Full Text Available Physical, chemical and functional features of apple starch. Apple juice contains some chemical agents like starch that may cause long-term turbidity, both in room temperature and refrigerated storage, with depreciation of the commercial value explained by the undesirable appearance. The objective of this article was to characterize some physical, chemical and functional features of purified apple starch as an earlier step aiming to establish the best conditions for its elimination from apple juice, according to routine processing. Apple starch was purified by an alkaline treatment with NaOH 0.15 N and washed with tap water down to neutral pH, and then dried at room temperature. Dry and purified cassava and corn starches were used as standards. Moisture level of apple starch was 13.5 g/100g, crude protein 0.03 g/100g, ash 2.49 g/100g, ether extract 0.04 g/100g and crude fiber 1.56 g/100g. Apple starch was characterized concerning chemical and functional aspects including rheological features like viscoelasticity, clarity and gel strength of the pastes. Apple starch granules in aqueous suspension were submitted to different temperatures aiming to determine their swelling power and solubility. Apple starch granules were also observed in scanning electronic microscope at 3.180x zoom. The results clearly show the apple starch with a functional behavior intermediate to the starches of cassava and of corn used as reference and may be used in order to establish an industrial procedure aiming to remove completely the starch during the processing of clarified apple juice.Os sucos de maçã apresentam agentes causais de turvação, entre eles o amido que, tanto à temperatura ambiente quanto sob refrigeração pode alterar sua aparência, o que determina uma perda de valor econômico do produto. O objetivo deste trabalho foi caracterizar o amido de maçã em relação a propriedades físicas, químicas e funcionais e com isso gerar informações cient

  5. EFEK PEMBERIAN SUSU SAPI BUBUK TERHADAP KADAR SERUM HDL (HIGH DENSITY LIPOPROTEIN PADA TIKUS PUTIH (Rattus norvegicus GALUR WISTAR MODEL DIABETES MELITUS TIPE 2

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    Zakia Umami

    2015-05-01

    Full Text Available ABSTRACTThe purpose of this study was to determine the cow’s milk powder to increased serum levels of High Density Lipoprotein (HDL of white male rat model with diabetes mellitus type 2. The design of this study was a post-test control group study conducted in 30 male rats which randomly divided into five groups. Negative control group was the group of rats which fed normally, the positive control group was induced by streptozotocin (STZ without given cow’s milk, group P1, P2, P3 were given a normal diet and cow’s milk 0.9; 1.8, and 2.7 g orally every day. The results of this study were the levels of HDL in K(-=44.22 mg/dl, K(+=47.45 mg/dl, P1=56.56 mg/dl, P2=51.82 mg/dl, and P3=59.45 mg/dl. The conclusion was the milk powder was not significantly increase levels of HDL (p>0.05. More longer intervention was suggested for further research to get more significant of HDL level on type 2 diabetes mellitus.Keywords: HDL serum level, high fat diet, milk powder, streptozotocinABSTRAKTujuan penelitian ini adalah menganalisis pengaruh pemberian susu sapi bubuk terhadap peningkatan kadar serum High Density Lipoprotein (HDL tikus putih (Rattus norvegicus berjenis kelamin jantan model diabetes melitus (DM tipe 2. Penelitian ini menggunakan desain penelitian post test control group dengan 30 ekor tikus dibagi secara acak menjadi lima kelompok. Kelompok K(- adalah tikus yang diberi pakan normal, kelompok K(+ diinduksi dengan streptozotocin (STZ tanpa diberi susu, kelompok P1 sampai P3 diberi diet normal dan susu 0,9; 1,8, dan 2,7 g secara oral setiap hari. Hasil penelitian menunjukkan kadar HDL pada K(-=44,22 mg/dl, K(+=47,45 mg/dl, P1=56,56 mg/dl, P2=51,82 mg/dl, dan P3=59,45 mg/dl. Susu sapi bubuk mampu meningkatkan kadar HDL tikus model DM tipe 2 akan tetapi tidak signifikan (p>0,05. Perlu dilakukan penelitian lebih lanjut dengan waktu lama penelitian yang berbeda sehingga bisa berdampak yang lebih signifikan untuk kadar HDL pada DM tipe 2.Kata kunci

  6. O que, afinal, a criança adquire ao adquirir uma língua?: a tarefa da aquisição da linguagem em três fases e o processamento de informação de interface pela criança

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    Corrêa, Letícia Maria Sicuro

    2007-01-01

    Full Text Available Três fases da pesquisa em aquisição da linguagem são caracterizadas em função do modo como a tarefa da criança é concebida na trajetória da teoria lingüística: como aquisição de regras, feixação de parâmetros e fixação de parâmetros restritos ao léxico, diante de imposições das interfaces da língua com sistemas de desempenho. Constata-se convergência nos desenvolvimentos de diferentes campos das ciências cognitivas com relação à necessidade de haver restrições à forma das gramáticas. O modo como propriedades de traços formais de elementos funcionais podem ser identificadas nas interfaces é considerado. Este envolve tanto procedimentos de natureza estatística quanto o sistema computacional lingüístico. Perspectivas com relação a uma teoria da aquisição da linguagem são consideradas, apontando-se para a necessidade de um modelo integrado da competência lingüística ser tomado como referência no desenvolvimento da mesma

  7. Levels of high-density lipoprotein cholesterol (HDL-C among children with steady-state sickle cell disease

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    Seixas Magda O

    2010-08-01

    Full Text Available Abstract Background The search for sickle cell disease (SCD prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up. We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C in steady-state children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, anti-aggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis. Methods We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter respectively. Clinical data were collected from patient medical records. Results Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol with hemoglobin (P Conclusions We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this complex network of markers and their role in SCD pathogenesis.

  8. The association between adiponectin, HDL-cholesterol and α1-antitrypsin-LDL in female subjects without metabolic syndrome.

    Science.gov (United States)

    Kotani, Kazuhiko; Yamada, Toshiyuki; Taniguchi, Nobuyuki

    2010-12-30

    Oxidized low-density lipoprotein (LDL) may act as an atheroprotective (anti-atherosclerotic) agent under some conditions. While the α1-antitrypsin (AT)-LDL complex is considered a type of oxidized LDL, its clinical relevance remains unknown. The aim of the present study was to investigate the association between AT-LDL and anti-atherosclerotic variables such as HDL-cholesterol and adiponectin in subjects with and without metabolic syndrome (MetS). In asymptomatic females (n = 194; mean age, 54 years) who were divided into non-MetS (n = 108) and MetS groups (n = 86), the fasting levels of serum AT-LDL, adiponectin and glucose/lipid panels were measured, in addition to body mass index (BMI) and blood pressure. The MetS group showed significantly higher BMI, blood pressure, glucose and triglyceride levels as well as significantly lower levels of HDL-cholesterol and adiponectin than the non-MetS group. A multivariate-adjusted analysis revealed that in the non-MetS group, AT-LDL was significantly, independently and positively correlated with adiponectin (β = 0.297, P cholesterol (β = 0.217, P LDL was significantly, independently and positively correlated with LDL-cholesterol only (β = 0.342, P LDL may exert anti-atherosclerotic effects in female subjects without MetS. More studies are required to clarify the clinical roles of AT-LDL in relation to the pathophysiology of MetS.

  9. Low HDL cholesterol but not high LDL cholesterol is independently associated with subclinical coronary atherosclerosis in healthy octogenarians.

    Science.gov (United States)

    Freitas, Wladimir M; Quaglia, Luiz A; Santos, Simone N; de Paula, Rafaela C S; Santos, Raul D; Blaha, Michael; Rivera, Juan J; Cury, Ricardo; Blumenthal, Roger; Nadruz-Junior, Wilson; Agatston, Arthur; Figueiredo, Valeria N; Nasir, Khurram; Sposito, Andrei C

    2015-02-01

    Although low-density lipoprotein cholesterol (LDL-C) has been consistently demonstrated a predictor of atherosclerotic disease in a large spectrum of clinical settings, among individuals aged of 80 years or older this concept is uncertain. This study was evaluated in a carefully selected population if the association between LDL-C and coronary atherosclerotic burden remains significant in the very elderly. Individuals aged of 80 years or older (n = 208) who spontaneously sought primary prevention care and have never manifested cardiovascular disease, malnutrition, neoplastic or consumptive disease were enrolled for a cross-sectional analysis. Medical evaluation, anthropometric measurements, blood tests and cardiac computed tomography were obtained. In analyses adjusted for age, gender, diabetes, systolic and diastolic blood pressure, smoking and statin therapy, no association was found between coronary calcium score (CCS) and LDL-C [1.79 (0.75-4.29)]. There was no association between triglycerides and CCS. The association between high-density lipoprotein cholesterol (HDL-C) and CCS was significant and robust in unadjusted [0.32 (0.15-0.67)] as well as in the fully adjusted analysis [0.34 (0.15-0.75)]. The present study confirms in a healthy cohort of individuals aged of 80 years or more that while the association between LDL-C and coronary atherosclerosis weakens with aging, the opposite occurs with the levels of HDL-C.

  10. Plasma lipids, lipoprotein metabolism and HDL lipid transfers are equally altered in metabolic syndrome and in type 2 diabetes.

    Science.gov (United States)

    Silva, Vanessa M; Vinagre, Carmen G C; Dallan, Luis A O; Chacra, Ana P M; Maranhão, Raul C

    2014-07-01

    Metabolic syndrome (MetS) refers to states of insulin resistance that predispose to development of cardiovascular disease and type 2 diabetes (T2DM). The aim was to investigate whether plasma lipids and lipid metabolism differ in MetS patients compared to those with T2DM with poor glycemic control (glycated hemoglobin > 7.0). Eighteen patients with T2DM, 18 with MetS and 14 controls, paired for age (40-70 years) and body mass index (BMI), were studied. Plasma lipids and the kinetics of a triacylglycerol-rich emulsion labeled with [(3)H]-triolein ([(3)H]-TAG) and [(14)C]-cholesteryl esters ([(14)C]-CE) injected intravenously followed by one-hour blood sampling were determined. Lipid transfers from an artificial nanoemulsion donor to high-density lipoprotien (HDL) were assayed in vitro. Low-density lipoprotein (LDL) and HDL cholesterol (mg/dl) were not different in T2DM (128 ± 7; 42 ± 7) and MetS (142 ± 6; 39 ± 3), but triacylglycerols were even higher in MetS (215 ± 13) than in T2DM (161 ±11, p lipid metabolism examined here, and suggest that there are different thresholds for the insulin action on glucose and lipids. These findings highlight the magnitude of the lipid disturbances in MetS, and may have implications in the prevention of cardiovascular diseases.

  11. Avaliação da estomatite protética em portadores de próteses totais

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    CARVALHO de OLIVEIRA Terezinha Rezende

    2000-01-01

    Full Text Available As próteses muco-suportadas são consideradas facilitadoras em potencial da estomatite protética (EP, lesão comumente observada sob a base das próteses, caracterizada por aspectos eritematosos difusos ou pontilhados na mucosa de suporte. Sua etiologia é controversa, podendo estar relacionada principalmente a fatores locais. Diversos aspectos funcionais associam-se a estes fatores representados pela oclusão, dimensão vertical, retenção, estabilidade dinâmica e estática além de aspectos qualitativos relacionados às condições encontradas no desdentado. Foram levados em consideração o período de edentulismo, número e tempo de uso das próteses, uso contínuo, conservação, presença de placa e higiene bucal. Os fatores foram avaliados, visando esclarecer a possível relação dos aspectos funcionais e protéticos com a EP. Exame clínico foi realizado em 116 pacientes de ambos os sexos, desdentados bimaxilares, que utilizavam as duas próteses muco-suportadas, portadores ou não de estomatite protética (EP. Os resultados indicaram que a maioria dos pacientes examinados tinha EP frente ao menor número de pacientes sem EP, havendo nos dois grupos equivalência nos resultados da avaliação clínica e protética. Os fatores funcionais e qualitativos das próteses, avaliados isoladamente, não puderam ser considerados responsáveis pela ocorrência dessa patologia, constatando-se que um único fator protético não demonstrou, de per si, ser responsável pela presença da EP, embora possa ser um facilitador para o seu desenvolvimento.

  12. Ser ou não ser: os conflitos funcionais do profissional no contexto das escolas de ensino superior no Brasil

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    Jalmir Pinheiro de Souza Júnior

    2013-12-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2013v6n4p49   As instituições de ensino superior brasileiras vêm passando por sucessivas mudanças desde a implementação da LDB, e consequente atuação do professor alicerçada na tríade ensino, pesquisa e extensão. Um processo de transformação em direção a conceber a universidade como empresa, orientada para as demandas do mercado, com cobranças por maior produtividade ganhou força. Este estudo qualitativo, interpretativista, visa ampliar a discussão dos impactos que este cenário tem causado nos docentes, e na realização da prática docente. Foram entrevistados nove docentes que se posicionaram por meio da exposição da experiência já vivenciada na sua atuação cotidiana. Os resultados, pós análise do discurso, evidenciaram a situação preocupante em que se encontra a classe de professores de ensino superior no Brasil, passando por frustrações e insatisfações, no campo profissional, que só fazem estimular o individualismo, aguçar a competitividade entre colegas, e a conseqüente queda na qualidade das relações estabelecidas entre alunos e professores. A desmotivação profissional tem se intensificado a cada período e é ilustrado pelo aumento dos conflitos e pela inquietação com a qual muitos já convivem, na dúvida iminente por ser ou não ser um professor universitário.

  13. JUNCTOPHILIN 3 (JPH3) EXPANSION MUTATIONS CAUSING HUNTINGTON DISEASE LIKE 2 (HDL2) ARE COMMON IN SOUTH AFRICAN PATIENTS WITH AFRICAN ANCESTRY AND A HUNTINGTON DISEASE PHENOTYPE

    Science.gov (United States)

    Krause, A; Mitchell, CL; Essop, F; Tager, S; Temlett, J; Stevanin, G; Ross, CA; Rudnicki, DD; Margolis, RL

    2015-01-01

    Huntington disease (HD) is a progressive autosomal dominant neurodegenerative disorder, characterized by abnormal movements, cognitive decline and psychiatric symptoms, caused by a CAG repeat expansion in the huntingtin (HTT) gene on chromosome 4p. A CAG/CTG repeat expansion in the junctophilin-3 (JPH3) gene on chromosome 16q24.2 causes a Huntington disease-like phenotype (HDL2). All patients to date with HDL2 have some African ancestry. The present study aimed to characterize the genetic basis of the Huntington disease phenotype in South Africans and to investigate the possible origin of the JPH3 mutation. In a sample of unrelated South African individuals referred for diagnostic HD testing, 62% (106/171) of white patients compared to only 36% (47/130) of black patients had an expansion in HTT. However, 15% (20/130) of black South African patients and no white patients (0/171) had an expansion in JPH3, confirming the diagnosis of Huntington disease like 2 (HDL2). Individuals with HDL2 share many clinical features with individuals with HD and are clinically indistinguishable in many cases, although the average age of onset and diagnosis in HDL2 is 5 years later than HD and individual clinical features may be more prominent. HDL2 mutations contribute significantly to the HD phenotype in South Africans with African ancestry. JPH3 haplotype studies in 31 families, mainly from South Africa and North America, provide evidence for a founder mutation and support a common African origin for all HDL2 patients. Molecular testing in individuals with an HD phenotype and African ancestry should include testing routinely for JPH3 mutations. PMID:26079385

  14. Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype.

    Science.gov (United States)

    Krause, Amanda; Mitchell, Claire; Essop, Fahmida; Tager, Susan; Temlett, James; Stevanin, Giovanni; Ross, Christopher; Rudnicki, Dobrila; Margolis, Russell

    2015-10-01

    Huntington disease (HD) is a progressive autosomal dominant neurodegenerative disorder, characterized by abnormal movements, cognitive decline, and psychiatric symptoms, caused by a CAG repeat expansion in the huntingtin (HTT) gene on chromosome 4p. A CAG/CTG repeat expansion in the junctophilin-3 (JPH3) gene on chromosome 16q24.2 causes a Huntington disease-like phenotype (HDL2). All patients to date with HDL2 have some African ancestry. The present study aimed to characterize the genetic basis of the Huntington disease phenotype in South Africans and to investigate the possible origin of the JPH3 mutation. In a sample of unrelated South African individuals referred for diagnostic HD testing, 62% (106/171) of white patients compared to only 36% (47/130) of black patients had an expansion in HTT. However, 15% (20/130) of black South African patients and no white patients (0/171) had an expansion in JPH3, confirming the diagnosis of Huntington disease like 2 (HDL2). Individuals with HDL2 share many clinical features with individuals with HD and are clinically indistinguishable in many cases, although the average age of onset and diagnosis in HDL2 is 5 years later than HD and individual clinical features may be more prominent. HDL2 mutations contribute significantly to the HD phenotype in South Africans with African ancestry. JPH3 haplotype studies in 31 families, mainly from South Africa and North America, provide evidence for a founder mutation and support a common African origin for all HDL2 patients. Molecular testing in individuals with an HD phenotype and African ancestry should include testing routinely for JPH3 mutations. © 2015 Wiley Periodicals, Inc.

  15. Relación entre paraoxonasa, otros componentes de HDL y estado inflamatorio en hemodiálisis

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    Ana Inés González

    2010-12-01

    Full Text Available La enfermedad renal crónica (ERC se asocia estrechamente con un estado pro-inflamatorio, aumento de lipoproteínas ricas en triglicéridos y disminución de HDL. La HDL contiene enzimas antioxidantes asociadas como la paraoxonasa (PON, cuya actividad en ERC se encuentra disminuida. Nuestro objetivo fue evaluar la relación entre la actividad de PON, apoA1, colesterol(col-HDL y Proteína C reactiva-altamente sensible (PCR-as como marcador de inflamación en pacientes en hemodiálisis. Se estudiaron n = 42 pacientes; edad, mediana (rango = 50 (25-67 años; sexo M/F = 22/20; antigüedad de hemodiálisis = 4.4 ± 0.5 años; índice de masa corporal (IMC = 23 ± 0.5 kg/m². Se obtuvo una muestra de sangre después de 12 h de ayuno y se determinaron los parámetros clásicos del perfil lipídico, se midieron los valores de apoproteínas A1 y B, PON a través de su actividad arilesterasa y PCR-as, la cual permitió dividir a los pacientes con PCR-as ≤ 1 (bajo riesgo, rango: 0.1 a 1.0 mg/l y > 1 mg/l (moderado y alto riesgo, 1.1 a 10.7 mg/l. Los niveles de triglicéridos, col-LDL y apoB no fueron diferentes entre los grupos. Los pacientes con PCR-as > 1 presentaron menor col-HDL (40 ± 2 mg/dl y apoA1 (118 ± 4 mg/dl que los pacientes con PCR-as ≤ 1 (50 ± 4 y 133 ± 5, respectivamente; p 1: 90.5 ± 24.0 μmol/ml.min que en PCR-as ≤ 1: 105.2 ± 18.0. Consecuentemente, se obtuvieron correlaciones inversas entre apoA1 y PCR-as, r = -0.381 p = 0.013 y entre PON y PCR-as, r = -0.32, p = 0.042. Además, el aumento de PCR-as correlacionó positivamente con el IMC, r = 0.318, p = 0.042. La disminución de col-HDL, apoA1 y PON en los individuos con mayor estado inflamatorio explicaría, en parte, el aumento de riesgo cardiovascular de estos pacientes, dado los efectos antiinflamatorios de la apoA1 y antioxidantes de la PON.

  16. INTERFERÊNCIA DE CRENÇAS NOS ALUNOS DA EJA NA DISCIPLINA DE INGLÊS

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    Maria Cristina Oliveira de Sá

    2015-06-01

    Full Text Available Este estudo é fruto de observações sistematizadas no campo específico da Educação de Jovens e Adultos no Instituto Federal do Espírito Santo (Ifes e tem como objetivo analisar as crenças sobre a aprendizagem do inglês dos alunos integrados ao Programa de Integração da Educação Profissional Técnica de Nível Médio na Modalidade de Educação de Jovens e Adultos (Proeja. Além disto, busca identificar e reestruturar as crenças disfuncionais, possibilitando a construção de novas crenças funcionais. Com o aporte teórico da psicologia cognitiva, dos estudos sobre crenças e seguindo os princípios e fundamentos da educação libertadora idealizada por Paulo Freire, a pesquisa fez uso de questionários e da técnica grupo focal para possibilitar a análise dos dados coletados no campo dentro de uma perspectiva qualitativo-quantitativa. A conclusão geral é que as crenças disfuncionais interferem negativamente na aprendizagem do inglês e demandam uma reestruturação orientada pelo professor comprometido conscientemente com a ideologia da inclusão.

  17. Alterações funcionais respiratórias na colecistectomia por via laparoscópica Functional respiratory changes in laparoscopic cholecystectomy

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    LUCIANA DIAS CHIAVEGATO

    2000-04-01

    Full Text Available Objetivo: Estudar as alterações da ventilação e volumes pulmonares e da força muscular respiratória no pós-operatório de colecistectomia por via laparoscópica. Tipo de estudo: Estudo prospectivo. Material e métodos: Foram avaliados 20 pacientes provenientes da enfermaria de gastrocirurgia da Unifesp, com média de idade 42,7 anos, sendo 7 (35% homens e 13 (65% mulheres. No período pré-operatório todos foram submetidos a um questionário clínico, exame físico, radiografia de tórax, espirometria. No pré e no pós-operatório foram obtidas as medidas da força muscular respiratória (pressões inspiratória e expiratória máximas, da ventilação pulmonar (volume corrente e volume minuto, da capacidade vital, a oximetria de pulso e o índice diafragmático (ID. Este índice é capaz de refletir o movimento toracoabdominal, determinado pelas mudanças nas dimensões ântero-posteriores da caixa torácica (CT e do abdome (AB e foi calculado utilizando-se a seguinte fórmula: ID = D AB/D AB + D CT. Resultados: Observou-se que os pacientes evoluíram no primeiro dia de pós-operatório com diminuição média significante de 26% do volume corrente, de 645ml ± 220ml para 475ml ± 135ml; 20% do volume minuto, de 15,0L ± 4,5L para 11,9L ± 3,6L; 36% da capacidade vital, de 2,7L ± 0,6L para 1,74L ± 0,7L; 47% da pressão inspiratória máxima, de -75 ± -22cm/H2O para -40 ± 17cm/H2O; 39% da pressão expiratória máxima, de +90 ± 28cm/H2O para +55 ± 28cm/H2O e 36% do índice diafragmático, de 0,60 ± 0,10 para 0,39 ± 0,14 (p Objective: The aim of this study was to measure the changes in lung volume, pulmonary ventilation, maximum respiratory muscle strength, and the incidence of pulmonary complications in patients undergoing elective laparoscopic cholecystectomy. Type of study: Prospective study. Material and methods: Twenty patients (7 men and 13 women with mean age of 42.7 years with normal respiratory function were studied. All

  18. Alterations in lipid transfers to HDL associated with the presence of coronary artery disease in patients with type 2 diabetes mellitus.

    Science.gov (United States)

    Sprandel, Marilia C O; Hueb, Whady A; Segre, Alexandre; Ramires, José A F; Kalil-Filho, Roberto; Maranhão, Raul C

    2015-08-14

    We previously showed that unesterified-cholesterol transfer to high-density lipoprotein (HDL), a crucial step in cholesterol esterification and role in reverse cholesterol transport, was diminished in non-diabetic patients with coronary artery disease (CAD). The aim was to investigate whether, in patients with type 2 diabetes mellitus (T2DM), the occurrence of CAD was also associated with alterations in lipid transfers and other parameters of plasma lipid metabolism. Seventy-nine T2DM with CAD and 76 T2DM without CAD, confirmed by cineangiography, paired for sex, age (40-80 years), BMI and without statin use, were studied. In vitro transfer of four lipids to HDL was performed by incubating plasma of each patient with a donor emulsion containing radioactive lipids during 1 h at 37 °C. Lipids transferred to HDL were measured after chemical precipitation of non-HDL fractions and the emulsion. Results are expressed as % of total radioactivity of each lipid in HDL. In T2DM + CAD, LDL-cholesterol and apo B were higher than in T2DM. T2DM + CAD also showed diminished transfer to HDL of unesterified cholesterol (T2DM + CAD = 7.6 ± 1.2; T2DM = 8.2 ± 1.5%, p < 0.01) and of cholesteryl-esters (4.0 ± 0.6 vs 4.3 ± 0.7, p < 0.01). Unesterified cholesterol in the non-HDL serum fraction was higher in T2DM + CAD (0.93 ± 0.20 vs 0.85 ± 0.15, p = 0.02) and CETP concentration was diminished (2.1 ± 1.0 vs 2.5 ± 1.1, p = 0.02). Lecithin-cholesterol acyltransferase activity, HDL size and lipid composition were equal. Reduction in T2DM + CAD of cholesterol transfer to HDL may impair cholesterol esterification and reverse cholesterol transport and altogether with simultaneous increased plasma unesterified cholesterol may facilitate CAD development in T2DM.

  19. Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1

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    Dan He

    2018-05-01

    Full Text Available Disruption of endothelial monolayer integrity is the primary instigating factor for many cardiovascular diseases. High density lipoprotein (HDL oxidized by heme enzyme myeloperoxidase (MPO is dysfunctional in promoting endothelial repair. Apolipoprotein A-1 mimetic 4F with its pleiotropic benefits has been proven effective in many in vivo models. In this study we investigated whether 4F promotes endothelial repair and restores the impaired function of oxidized HDL (Cl/NO2-HDL in promoting re-endothelialization. We demonstrate that 4F and Cl/NO2-HDL act on scavenger receptor type I (SR-B1 using human aorta endothelial cells (HAEC and SR-B1 (-/- mouse aortic endothelial cells. Wound healing, transwell migration, lamellipodia formation and single cell migration assay experiments show that 4F treatment is associated with a recovery of endothelial cell migration and associated with significantly increased endothelial nitric oxide synthase (eNOS activity, Akt phosphorylation and SR-B1 expression. 4F increases NO generation and diminishes oxidative stress. In vivo, 4F can stimulate cell proliferation and re-endothelialization in the carotid artery after treatment with Cl/NO2-HDL in a carotid artery electric injury model but fails to do so in SR-B1(-/- mice. These findings demonstrate that 4F promotes endothelial cell migration and has a potential therapeutic benefit against early endothelial injury in cardiovascular diseases.

  20. Effect of rimonabant on the high-triglyceride/ low-HDL-cholesterol dyslipidemia, intraabdominal adiposity, and liver fat: the ADAGIO-Lipids trial.

    Science.gov (United States)

    Després, Jean-Pierre; Ross, Robert; Boka, Gabor; Alméras, Natalie; Lemieux, Isabelle

    2009-03-01

    Rimonabant, the first selective cannabinoid type 1 (CB1) receptor antagonist, improves cardiometabolic risk factors in overweight/obese patients. ADAGIO-Lipids assessed the effect of rimonabant on cardiometabolic risk factors and intraabdominal and liver fat. 803 abdominally obese patients with atherogenic dyslipidemia (increased triglycerides [TG] or reduced high-density lipoprotein-cholesterol [HDL-C]) were randomized to placebo or rimonabant 20 mg/d for 1 year. HDL-C and TG were coprimary end points. Intraabdominal (visceral) and liver fat were measured by computed tomography in a subgroup of 231 patients. In total, 73% of rimonabant- and 70% of placebo-treated patients completed the study treatment. Rimonabant 20 mg produced significantly greater changes from baseline versus placebo in HDL-C (+7.4%) and TG levels (-18%; PA1 and B, HDL2, HDL3, C-reactive protein, and adiponectin levels (all Pblood pressure were significantly reduced with rimonabant versus placebo (P<0.0001). The safety profile of rimonabant was consistent with previous studies; gastrointestinal, nervous system, psychiatric, and general adverse events were more common with rimonabant 20 mg. In abdominally obese patients with atherogenic dyslipidemia, rimonabant 20 mg significantly improved multiple cardiometabolic risk markers and induced significant reductions in both intraabdominal and liver fat.

  1. Discovery of molecular mechanism of a clinical herbal formula upregulating serum HDL-c levels in treatment of metabolic syndrome by in vivo and computational studies.

    Science.gov (United States)

    Chen, Meimei; Yang, Fafu; Kang, Jie; Gan, Huijuan; Lai, Xinmei; Gao, Yuxing

    2018-01-15

    Decreased HDL cholesterol (HDL-c) is considered as an independent risk factor of cardiovascular disease in metabolic syndrome (Mets). Wendan decoction (WDD), a famous clinical traditional Chinese medicine formula in Mets in China, which can obviously up-regulate serum HDL-c levels in Mets. However, till now, the molecular mechanism of up-regulation still remained unclear. In this study, an integrated approach that combined serum ABCA1 in vivo assay, QSAR modeling and molecular docking was developed to explore the molecular mechanism and chemical substance basis of WDD upregulating HDL-c levels. Compared with Mets model group, serum ABCA1 and HDL-c levels intervened by two different doses of WDD for two weeks were significantly up-regulated. Then, kohonen and LDA were applied to develop QSAR models for ABCA1 up-regulators based flavonoids. The derived QSAR model produced the overall accuracy of 100%, a very powerful tool for screening ABCA1 up-regulators. The QSAR model prediction revealed 67 flavonoids in WDD were ABCA1 up-regulators. Finally, they were subjected to the molecular docking to understand their roles in up-regulating ABCA1 expression, which led to discovery of 23 ABCA1 up-regulators targeting LXR beta. Overall, QSAR modeling and docking studies well accounted for the observed in vivo activities of ABCA1 affected by WDD. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport[S

    Science.gov (United States)

    Kuwano, Takashi; Bi, Xin; Cipollari, Eleonora; Yasuda, Tomoyuki; Lagor, William R.; Szapary, Hannah J.; Tohyama, Junichiro; Millar, John S.; Billheimer, Jeffrey T.; Lyssenko, Nicholas N.; Rader, Daniel J.

    2017-01-01

    Phospholipid transfer protein (PLTP) may affect macrophage reverse cholesterol transport (mRCT) through its role in the metabolism of HDL. Ex vivo cholesterol efflux capacity and in vivo mRCT were assessed in PLTP deletion and PLTP overexpression mice. PLTP deletion mice had reduced HDL mass and cholesterol efflux capacity, but unchanged in vivo mRCT. To directly compare the effects of PLTP overexpression and deletion on mRCT, human PLTP was overexpressed in the liver of wild-type animals using an adeno-associated viral (AAV) vector, and control and PLTP deletion animals were injected with AAV-null. PLTP overexpression and deletion reduced plasma HDL mass and cholesterol efflux capacity. Both substantially decreased ABCA1-independent cholesterol efflux, whereas ABCA1-dependent cholesterol efflux remained the same or increased, even though preβ HDL levels were lower. Neither PLTP overexpression nor deletion affected excretion of macrophage-derived radiocholesterol in the in vivo mRCT assay. The ex vivo and in vivo assays were modified to gauge the rate of cholesterol efflux from macrophages to plasma. PLTP activity did not affect this metric. Thus, deviations in PLTP activity from the wild-type level reduce HDL mass and ex vivo cholesterol efflux capacity, but not the rate of macrophage cholesterol efflux to plasma or in vivo mRCT. PMID:28137768

  3. Metabólitos secundários presentes na Annona muricata L e suas propriedades nutricionais e funcionais em oncologia

    OpenAIRE

    Erlania Carmo Freitas; Maria Olímpia Batista de Moraes; Ana Carolina Morais Silva

    2017-01-01

    A nutrição funcional tem ganhado espaço nos últimos anos por sua ação terapêutica, com destaque para o fruto graviola. Vários estudos bem conduzidos sugerem que o fruto possui quantidades consideráveis de minerais, fibras, compostos antioxidantes e substancias que atuam contra células cancerígenas, com destaque para a ação das acetogeninas. Contudo objetivou-se realizar a quantificação dos compostos fenólicos presentes em polpas da graviola in natura e congelada e realizar uma revisão de trab...

  4. Desenvolvimento de uma tecnologia de produção de iogurtes funcionais com leite de cabra contendo fibra Beta vulgaris e frutos de Vaccinium cylindraceum

    OpenAIRE

    Tavares, Mónica Torres

    2014-01-01

    Dissertação de Mestrado, Tecnologia e Segurança Alimentar, 02 de Junho de 2014, Universidade dos Açores. […]. No presente trabalho foi desenvolvido um iogurte funcional utilizando matériasprimas selecionadas e provenientes da RAA, destinado sobretudo a pessoas de terceira idade que geralmente apresentam maior risco de deficiências nutricionais do que os jovens e os adultos, acrescido às alterações fisiológicas associadas ao processo de envelhecimento. Nas várias formulações a estudar usou-...

  5. Repercussões morfológicas e funcionais do exercício sobre a regeneração nervosa periférica

    Directory of Open Access Journals (Sweden)

    Fernanda Possamai

    Full Text Available INTRODUÇÃO: A indicação de exercícios físicos como abordagem terapêutica após lesões nervosas periféricas, apesar de resultados clínicos favoráveis, ainda não é consenso na literatura pertinente. Objetivos: Este estudo buscou avaliar a interferência do exercício em roda motorizada no processo de regeneração nervosa periférica. MATERIAIS E MÉTODOS: Foram utilizados 48 ratos Wistar divididos proporcionalmente em quatro grupos de 12 ratos cada (seis controles e seis experimentais. Após treinamento, os ratos foram submetidos à axonotmese do nervo ciático direito. Todos os grupos iniciaram o regime de exercícios diários 24 horas após a lesão, porém com durações diferenciadas (G1 por 28 dias; G2 por 21 dias, G3 por 14 dias e G4 por sete dias. O exercício teve tempo e velocidade ajustados de acordo com o tempo de tratamento para cada grupo. RESULTADOS: Por meio do cálculo do Índice Funcional do Ciático, os animais submetidos ao exercício apresentaram sinais de atraso na recuperação funcional da marcha, em comparação a animais controles. Na análise histológica dos nervos lesionados, observou-se que animais exercitados apresentaram sinais de preservação dos axônios no coto proximal e de degeneração no coto distal, e os animais exercitados por somente sete dias não apresentaram a mesma característica degenerativa no coto distal. A aplicação de exercícios ativos e sem carga em animais que sofreram axonotmese interfere negativamente no processo de recuperação funcional de alguns parâmetros da marcha. CONCLUSÃO: Apesar de o exercício ativo não ter interferido na manutenção da viabilidade neuronal nos sítios proximais à lesão, sua continuidade prejudicou a viabilidade dos cotos neurais distais, provável causa do atraso na recuperação funcional da marcha.

  6. Cholesteryl Ester Transfer Protein (CETP polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk.

    Directory of Open Access Journals (Sweden)

    Audrey C Papp

    Full Text Available Polymorphisms in and around the Cholesteryl Ester Transfer Protein (CETP gene have been associated with HDL levels, risk for coronary artery disease (CAD, and response to therapy. The mechanism of action of these polymorphisms has yet to be defined. We used mRNA allelic expression and splice isoform measurements in human liver tissues to identify the genetic variants affecting CETP levels. Allelic CETP mRNA expression ratios in 56 human livers were strongly associated with several variants 2.5-7 kb upstream of the transcription start site (e.g., rs247616 p = 6.4 × 10(-5, allele frequency 33%. In addition, a common alternatively spliced CETP isoform lacking exon 9 (Δ9, has been shown to prevent CETP secretion in a dominant-negative manner. The Δ 9 expression ranged from 10 to 48% of total CETP mRNA in 94 livers. Increased formation of this isoform was exclusively associated with an exon 9 polymorphism rs5883-C>T (p = 6.8 × 10(-10 and intron 8 polymorphism rs9930761-T>C (5.6 × 10(-8 (in high linkage disequilibrium with allele frequencies 6-7%. rs9930761 changes a key splicing branch point nucleotide in intron 8, while rs5883 alters an exonic splicing enhancer sequence in exon 9.The effect of these polymorphisms was evaluated in two clinical studies. In the Whitehall II study of 4745 subjects, both rs247616 and rs5883T/rs9930761C were independently associated with increased HDL-C levels in males with similar effect size (rs247616 p = 9.6 × 10(-28 and rs5883 p = 8.6 × 10(-10, adjusted for rs247616. In an independent multiethnic US cohort of hypertensive subjects with CAD (INVEST-GENE, rs5883T/rs9930761C alone were significantly associated with increased incidence of MI, stroke, and all-cause mortality in males (rs5883: OR 2.36 (CI 1.29-4.30, p = 0.005, n = 866. These variants did not reach significance in females in either study. Similar to earlier results linking low CETP activity with poor outcomes in males, our results suggest genetic, sex

  7. Description of Discordance Between LDL Cholesterol, Non-HDL Cholesterol, and LDL Particle Number Among Patients of a Lipid Clinic

    Directory of Open Access Journals (Sweden)

    Joshua W Gaborcik

    2017-09-01

    Full Text Available Background: While LDL cholesterol measures the cholesterol content within an LDL particle (LDL-P, it may not reflect LDL-P concentrations. If discordance exists, LDL-P may better predict cardiovascular events compared to LDL-C and non-HDL cholesterol (non-HDL-C. In primary prevention patients, discordance has been associated with diabetes, ethnicity, gender, metabolic syndrome, and smoking history. Objective: To describe discordance in patients of a lipid clinic by exploring associations between patient characteristics and discordance among LDL-C, non-HDL-C, or LDL-P. Secondarily to compare proportion of patients with baseline concordance versus discordance who have ASCVD events, diagnoses of new onset diabetes or death. Methods: A retrospective, single-center cohort study at a large academic medical center was conducted. Patients establishing care from January 2009 through December 2012 with complete initial labs were included. Logistic regression models were used to explore associations between discordance and patient characteristics. Results: Of 603 patients screened, the final cohort included 166 patients with 104 (62.7% discordant. LDL-P was the most common discordant value. Discordance was associated with gender, smoking status, use of lipid lowering medications, and achieving patient specific LDL-C goals. In terms of any event observed after initial measurements, no significant differences were detected between discordant and concordant groups. Conclusion: Within a lipid clinic population, discordance was associated with male gender, smoking status, lipid-lowering therapy, and being at patient specific LDL-C goal. While associations were found in our population, clinicians should consider measuring LDL-P to fully assess presence or extent of discordance. Conflict of Interest We declare no conflicts of interest or financial interests that the authors or members of their immediate families have in any product or service discussed in the

  8. Doenças osteomusculares e articulares em idosos atendidos em um centro de reabilitação de um hospital universitário: descrição da prevalência e do perfil demográfico e de saúde

    OpenAIRE

    Rosito, Miriam Pilla

    2012-01-01

    O envelhecimento da população leva ao incremento dos distúrbios crônico-degenerativos, entre eles as doenças osteomusculares e articulares (DOMA), das quais as lombalgias estão entre as mais prevalentes e sintomáticas em idosos. As DOMA resultam em deficiências funcionais que impactam negativamente na independência e na qualidade de vida de idosos. Deste modo, determinar o perfil daqueles acometidos por DOMA é importante para a gestão e o planejamento de ações em saúde. Assim, a presente diss...

  9. As bases moleculares da hemofilia A

    Directory of Open Access Journals (Sweden)

    Simone Ferreira Pio

    2009-01-01

    Full Text Available As hemofilias são doenças hemorrágicas resultantes da deficiência de fator VIII (hemofilia A ou de fator IX (hemofilia B da coagulação, decorrentes de mutações nos genes que codificam os fatores VIII ou IX, respectivamente. A hemofilia A é mais frequente que a hemofilia B e acomete aproximadamente 1:10.000 nascimentos masculinos. A gravidade e frequência dos episódios hemorrágicos está relacionado ao nível residual de atividade de fator VIII presente no plasma e este relaciona-se ao tipo de mutação associada à doença. A clonagem do gene do fator VIII tornou possível o conhecimento das bases moleculares da hemofilia A, sendo hoje conhecidas mais de 1.000 mutações associadas à doença. O conhecimento das bases moleculares da hemofilia A permite uma melhor compreensão da relação genótipo-fenótipo da doença, tomada de condutas clínicas diferenciadas em casos de mutações associadas a um maior risco de desenvolvimento de inibidor, determinação da condição de portadora de hemofilia em mulheres relacionadas aos pacientes, implementação de programa de aconselhamento genético/orientação familiar e melhor compreensão das relações estruturais-funcionais do gene-proteína. Este artigo propõe revisar as bases moleculares da hemofilia A, os métodos laboratoriais utilizados para a caracterização das mutações e as implicações clínicas envolvidas no diagnóstico molecular da hemofilia A.Hemophilias are bleeding disorders due to deficiency of the blood coagulation factor VIII (hemophilia A or factor IX (hemophilia B, resulting from mutation on the gene coding for factor VIII or factor IX. Hemophilia A is more frequent than hemophilia B and affects 1:10,000 male newborns. The severity and frequency of hemorrhagic episodes is related to residual activity of factor VIII present in the plasma and relates to the type of mutation associated with the disorder. Cloning of the factor VIII gene has enabled researchers to

  10. Avaliação da simetria e descarga de peso entre os membros inferiores de atletas de futebol da categoria de base

    Directory of Open Access Journals (Sweden)

    Daniel Lucas Spagnuolo

    2013-12-01

    Full Text Available INTRODUÇÃO: A avaliação instrumentada dos saltos verticais informa sobre as capacidades funcionais e variáveis neuromusculares, auxiliando no atendimento dos atletas. Essencial dar atenção maior para as categorias de base, pois contém fases importantes do desenvolvimento dos atletas que serão o futuro do esporte. Objetivo: Avaliar as características funcionais e neuromusculares de atletas de futebol da categoria de base, no desempenho em saltos verticais. METODOLOGIA: Foram avaliados atletas de futebol com idade entre 15 e 17 anos. Foram realizados em duas plataformas de força os seguintes saltos verticais: salto em agachamento, salto em contramovimento, salto pliométrico de 40 cm de altura. Para análise das variáveis das forças concêntrica, excêntrica, impacto e altura dos saltos utilizou-se a prova estatística de Shapiro-Wilk, descrição das variáveis em média e desvio padrão, considerando quando p 0,05. Sem diferença na força concêntrica entre as categorias e os tipos de saltos. Maior força de impacto no contramovimento. Maior força em membro inferior direito em todos os saltos e variáveis de força. CONCLUSÕES: Encontramos assimetria entre os membros inferiores, podendo correlacionar com um déficit de potência muscular, má desaceleração do movimento e erros biomecânicos. Fatores predisponentes a lesões musculoesqueléticas, os quais podem ser prevenidos. A avaliação instrumentada da força através desses testes pode subsidiar os profissionais do clube como uma ferramenta de trabalho, capaz de aprimorar o treinamento, preparação e reabilitação. Entretanto, são necessárias mais pesquisas, de forma que momentos distintos da idade e da temporada do atleta sejam avaliados.

  11. 2,4,5,2',4',5'-Hexachlorobiphenyl-lipoprotein (LDL, HDL, VLDL) interaction and induced lipidosis in cultured skin fibroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Kling, D.; Becker, M.M.; Kruth, H.S.; Gamble, W.

    1984-06-01

    2,4,5,2',4',5'-Hexachlorobiphenyl (HCB) induced cytoplasmic inclusions and lipidosis in normal (AG1437) and hypercholesterolemic (GM488) human skin fibroblasts. Quantitative and qualitative microscopic fluorescence analysis showed that the cytoplasmic inclusions are formed as early as 3 hr after treatment with HCB. The inclusions contain lipids but no detectable nonesterified cholesterol or cholesteryl ester. High density lipoproteins (HDL), low density lipoproteins (LDL), and very low density lipoproteins (VLDL) facilitate the apparent uptake of HCB by skin fibroblasts. HDL and LDL appeared to reverse the induction of cytoplasmic inclusions and lipidosis when cells were pretreated with HCB, the HCB was removed from media, and the cells were incubated with LDL or HDL. The results suggest that lipoproteins participate in the uptake and egress of HCB from skin fibroblasts.

  12. High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression

    DEFF Research Database (Denmark)

    Feuerborn, Renata; Becker, Susen; Potì, Francesco

    2017-01-01

    BACKGROUND AND AIMS: Macrophage apoptosis is critically involved in atherosclerosis. We here examined the effect of anti-atherogenic high density lipoprotein (HDL) and its component sphingosine-1-phosphate (S1P) on apoptosis in RAW264.7 murine macrophages. METHODS: Mitochondrial or endoplasmic...... reticulum-dependent apoptosis was induced by exposure of macrophages to etoposide or thapsigargin/fukoidan, respectively. RESULTS: Cell death induced by these compounds was inhibited by S1P as inferred from reduced annexin V binding, TUNEL staining, and caspase 3, 9 and 12 activities. S1P induced expression......) and Janus kinase 2 (JAK2) and the stimulatory effect of S1P on survivin expression and inhibitory effects on apoptosis were attenuated by STAT3 or JAK2 inhibitors, S3I-201 or AG490, respectively. The effects of S1P on STAT3 activation, survivin expression and macrophage apoptosis were emulated by HDL, HDL...

  13. Initial test results from the HDL-varian injection-locked, conventional emission, high power magnetron program

    International Nuclear Information System (INIS)

    Smith, R.S. III; Treado, T.A.N.; Thomas, G.E.; Robertson, J.A.; Pomeroy, R.D.; Barry, J.D.; Kehns, R.A.; Bromborsky, A.

    1990-01-01

    The authors report on the development of high power, high energy microwave modules. The HDL-Varian high-power magnetron program is unique in the HPM field in that established crossed-field tube technologies are being exploited in order to circumvent many of the difficulties inherent in other HPM sources. Instead of using explosive field emission cathodes, short pulse lengths, and extremely high voltages, the authors are operating with secondary emission cathodes, carefully conditioned high vacuum surfaces, and more moderate dc and rf fields. As a result, typical crossed-field tube properties are expected including long pulse lengths, high efficiency, relatively low operating voltages and magnetic fields, and high phase stability and control using well isolated low-power rf drivers. High efficiency and moderate voltages allow for the use of proven high repetition rate modulator technology. Preliminary results from an 18-vane rising sun magnetron are presented

  14. Monocyte to HDL ratio in prediction of BMS restenosis in subjects with stable and unstable angina pectoris.

    Science.gov (United States)

    Tok, Derya; Turak, Osman; Yayla, Çağrı; Ozcan, Fırat; Tok, Duran; Çağlı, Kumral

    2016-08-01

    This study aims to assess the predictive role of the preprocedural circulating monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) on the occurrence of stent restenosis (SR) in patients with stable and unstable angina pectoris undergoing successful bare-metal stenting (BMS). Between February 2008 and June 2014, a total of 831 patients with stable and unstable angina pectoris who underwent successful BMS were retrospectively analyzed. Demographic and clinical characteristics of the patients were recorded. Left ventricular ejection fraction and laboratory data were also noted. In the receiver operating characteristics curve analysis, MHR >14 had 71% sensitivity and 69% specificity in predicting SR. Our study results show that preprocedural MHR is an independent predictor of SR in this patient population.

  15. Incident type 2 diabetes is associated with HDL, but not with its anti-oxidant constituent - paraoxonase-1: The prospective cohort PREVEND study.

    Science.gov (United States)

    Kunutsor, Setor K; Kieneker, Lyanne M; Bakker, Stephan J L; James, Richard W; Dullaart, Robin P F

    2017-08-01

    High-density lipoprotein cholesterol (HDL-C) is an established risk marker for cardiovascular disease and consistently associated with type 2 diabetes risk. Serum paraoxonase-1 (PON-1) - an anti-oxidant constituent of HDL - is inversely associated with cardiovascular disease risk, but its relationship with incident type 2 diabetes is uncertain. We aimed to investigate the prospective association between PON-1 and type 2 diabetes risk. PON-1 was measured as its arylesterase activity at baseline in the Prevention of Renal and Vascular End-stage Disease (PREVEND) prospective study of 5947 predominantly Caucasian participants aged 28-75years with no pre-existing diabetes, that recorded 500 type 2 diabetes cases during a median follow-up of 11.2years. Serum PON-1 was positively correlated with HDL-C (r=0.17; P<0.001). In analyses adjusted for conventional diabetes risk factors, the hazard ratio (95% CI) for type 2 diabetes per 1 standard deviation increase in PON-1 was 1.07 (0.98 to 1.18; P=0.13), which remained non-significant (1.02 (0.93 to 1.12) P=0.65) after additional adjustment for potential confounders. The association was unchanged on further adjustment for HDL-C (1.05 (0.96 to 1.15; P=0.29). However, in subsidiary analyses in the same set of participants, serum HDL-C concentration was inversely and independently associated with risk of type 2 diabetes. Incident type 2 diabetes is associated with HDL cholesterol but not with its anti-oxidant constituent - PON-1 - in a large cohort of apparently healthy men and women. The current data question the importance of PON-1 activity for the development of diabetes. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. The association of the triglyceride-to-HDL cholesterol ratio with insulin resistance in White European and South Asian men and women.

    Science.gov (United States)

    Mostafa, Samiul A; Davies, Melanie J; Morris, Danielle H; Yates, Tom; Srinivasan, Balasubramanian Thiagarajan; Webb, David; Brady, Emer; Khunti, Kamlesh

    2012-01-01

    There is recent interest surrounding the use of the triglyceride-to-HDL cholesterol ratio as a surrogate marker of insulin resistance in clinical practice, as it may identify people at high risk of developing diabetes or its complications. However, it has been suggested using this lipid ratio may not be appropriate for measuring insulin resistance in African-Americans, particularly women. We investigated if this inconsistency extended to South Asian women in a UK multi-ethnic cohort of White Europeans and South Asians. Cross-sectional analysis was done of 729 participants from the ADDITION-Leicester study from 2005 to 2009. The association between tertiles of triglyceride-to-HDL cholesterol ratio to fasting insulin, homeostatic model of assessment for insulin resistance (HOMA1-IR), quantitative insulin sensitivity check index (QUICKI) and glucose: insulin ratio was examined with adjustment for confounding variables. Incremental tertiles of the triglyceride-to-HDL cholesterol ratio demonstrated a significant positive association with levels of fasting insulin, HOMA1-IR, glucose: insulin ratio and a negative association with QUICKI in White European men (n = 255) and women (n = 250) and South Asian men (n = 124) (all pAsian women (n = 100). A significant interaction was demonstrated between sex and triglyceride-to-HDL cholesterol ratio tertiles in South Asians only (pwomen, South Asian men and women respectively. The optimal cut-points for detecting insulin resistance were 0.9-1.7 in mmol/l (2.0-3.8 in mg/dl) for the triglyceride-to-HDL ratio. In South Asian women the triglyceride-to-HDL cholesterol ratio was not associated with insulin resistance; therefore there may be limitations in its use as a surrogate marker in this group.

  17. The atherogenic dyslipidemia ratio [log(TG/HDL-C] is associated with residual vascular risk, beta-cell function loss and microangiopathy in type 2 diabetes females

    Directory of Open Access Journals (Sweden)

    Hermans Michel P

    2012-10-01

    Full Text Available Abstract Background Atherogenic dyslipidemia (AD, defined as low HDL-C plus elevated triglycerides (TG, comorbid to T2DM, increases cardiometabolic risk for CAD even when LDL-C is at target. In T2DM males, AD was shown to correlate with β-cell function loss, yet it is not established whether this applies across gender. Aim To establish the prevalence and severity of AD in T2DM females, and to determine how it relates to cardiometabolic phenotype, glucose homeostasis, micro- and macrovascular complications, and 10-year absolute CV risk (UKPDS Risk Engine. Methods 340 T2DM females were ranked according to quintiles (Q of the continuous variable log(TG/HDL-C, with AD prevalence defined as HDL-C -1 plus TG ≥150 mg.dL-1, and β-cell function assessed with HOMA. Results AD prevalence was 35%; mean HDL-C and TG were 52 (15 and 160 (105 mg.dL-1. AD was significantly related to central fat, metabolic syndrome, sedentarity and skeletal sarcopenia, as well as to hsCRP, fibrinogen, uric acid, cystatin-C, Big ET-1, and 10-year UKPDS CV risk. AD correlated stepwise with lower β-cell function and hyperbolic product, and with accelerated loss of residual insulin secretion, higher HbA1c and prevalent microangiopathy. Conclusions log(TG/HDL-C is a simple means to grade AD and residual macrovascular risk in T2DM females. This ratio associates with major non-LDL cardiometabolic variables and ranks predicted CAD risk. In addition, log(TG/HDL-C identifies worsening glucose homeostasis, poorer glycemic control, and prevalent microangiopathy.

  18. High prevalence of low HDL-c in the Philippines compared to the U.S.: population differences in associations with diet and BMI

    Science.gov (United States)

    Rutherford, Julienne N.; McDade, Thom W.; Feranil, Alan; Adair, Linda; Kuzawa, Christopher

    2011-01-01

    Cardiovascular disease (CVD) is a leading cause of death in the Philippines, although few studies here have examined the lipid profiles underlying disease risk. The isolated low high density lipoprotein cholesterol (HDL-c) phenotype has been implicated as a CVD risk factor, the prevalence of which exhibits significant variation across populations. To assess population variation in individual lipid components and their associations with diet and anthropometric characteristics, we compare lipid profiles in a population of adult Filipino women (n=1877) to U.S. women participating in the National Health and Nutrition Examination Survey (n=477). We conducted multilinear regression models to assess the relationship between lipid components and BMI and dietary variables in the two populations. We measured the prevalence of lipid phenotypes, and logistic regression models determined the predictors of the isolated low HDL-c phenotype. HDL-c was lower in the Philippines (40.8±0.2 mg/dL) than in NHANES (60.7±0.7 mg/dL). The prevalence of the isolated low HDL-c phenotype was 28.8%, compared to 2.10% in NHANES. High prevalence among Filipinos was relatively invariant across all levels of BMI, but was strongly inversely related to BMI in NHANES and exhibited only at the BMI>25 kg/m2 threshold. Diet did not predict the low-HDL phenotype in Filipinos. Filipino women exhibit a high prevalence of the isolated low HDL-c phenotype, which is largely decoupled from anthropometric factors. The relationship of CVD to population variation in dyslipidemia and body composition needs further study, particularly in populations where the burden of cardiovascular and metabolic disease is rapidly increasing. PMID:20199988

  19. Beneficial Effects of Reconstituted High-Density Lipoprotein (rHDL on Circulating CD34+ Cells in Patients after an Acute Coronary Syndrome.

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    Catherine Gebhard

    Full Text Available High-density lipoproteins (HDL favorably affect endothelial progenitor cells (EPC. Circulating progenitor cell level and function are impaired in patients with acute coronary syndrome (ACS. This study investigates the short-term effects of reconstituted HDL (rHDL on circulating progenitor cells in patients with ACS.The study population consisted of 33 patients with recent ACS: 20 patients from the ERASE trial (randomized to receive 4 weekly intravenous infusions of CSL-111 40 mg/kg or placebo and 13 additional patients recruited as controls using the same enrolment criteria. Blood was collected from 16 rHDL (CSL-111-treated patients and 17 controls at baseline and at 6-7 weeks (i.e. 2-3 weeks after the fourth infusion of CSL-111 in ERASE. CD34+ and CD34+/kinase insert domain receptor (KDR+ progenitor cell counts were analyzed by flow cytometry. We found preserved CD34+ cell counts in CSL-111-treated subjects at follow-up (change of 1.6%, while the number of CD34+ cells was reduced (-32.9% in controls (p = 0.017 between groups. The level of circulating SDF-1 (stromal cell-derived factor-1, a chemokine involved in progenitor cell recruitment, increased significantly (change of 21.5% in controls, while it remained unchanged in CSL-111-treated patients (p = 0.031 between groups. In vitro exposure to CSL-111 of early EPC isolated from healthy volunteers significantly increased CD34+ cells, reduced early EPC apoptosis and enhanced their migration capacity towards SDF-1.The relative increase in circulating CD34+ cells and the low SDF-1 levels observed following rHDL infusions in ACS patients point towards a role of rHDL in cardiovascular repair mechanisms.

  20. Metabolism of triglyceride-rich lipoproteins and transfer of lipids to high-density lipoproteins (HDL) in vegan and omnivore subjects.

    Science.gov (United States)

    Vinagre, J C; Vinagre, C G; Pozzi, F S; Slywitch, E; Maranhão, R C

    2013-01-01

    Vegan diet excludes all foodstuffs of animal origin and leads to cholesterol lowering and possibly reduction of cardiovascular disease risk. The aim was to investigate whether vegan diet improves the metabolic pathway of triglyceride-rich lipoproteins, consisting in lipoprotein lipolysis and removal from circulation of the resulting remnants and to verify whether the diet alters HDL metabolism by changing lipid transfers to this lipoprotein. 21 vegan and 29 omnivores eutrophic and normolipidemic subjects were intravenously injected triglyceride-rich emulsions labeled with (14)C-cholesterol oleate and (3)H-triolein: fractional clearance rates (FCR, in min(-1)) were calculated from samples collected during 60 min for radioactive counting. Lipid transfer to HDL was assayed by incubating plasma samples with a donor nanoemulsion labeled with radioactive lipids; % lipids transferred to HDL were quantified in supernatant after chemical precipitation of non-HDL fractions and nanoemulsion. Serum LDL cholesterol was lower in vegans than in omnivores (2.1 ± 0.8, 2.7 ± 0.7 mmol/L, respectively, p triglycerides were equal. Cholesteryl ester FCR was greater in vegans than in omnivores (0.016 ± 0.012, 0.003 ± 0.003, p triglyceride FCR was equal (0.024 ± 0.014, 0.030 ± 0.016, N.S.). Cholesteryl ester transfer to HDL was lower in vegans than in omnivores (2.7 ± 0.6, 3.5 ± 1.5%, p triglyceride and phospholipid transfer were equal, as well as HDL size. Remnant removal from circulation, estimated by cholesteryl oleate FCR was faster in vegans, but the lipolysis process, estimated by triglyceride FCR was equal. Increased removal of atherogenic remnants and diminution of cholesteryl ester transfer may favor atherosclerosis prevention by vegan diet. Copyright © 2011 Elsevier B.V. All rights reserved.

  1. Metabólitos secundários presentes na Annona muricata L e suas propriedades nutricionais e funcionais em oncologia

    Directory of Open Access Journals (Sweden)

    Erlania Carmo Freitas

    2017-01-01

    Full Text Available A nutrição funcional tem ganhado espaço nos últimos anos por sua ação terapêutica, com destaque para o fruto graviola. Vários estudos bem conduzidos sugerem que o fruto possui quantidades consideráveis de minerais, fibras, compostos antioxidantes e substancias que atuam contra células cancerígenas, com destaque para a ação das acetogeninas. Contudo objetivou-se realizar a quantificação dos compostos fenólicos presentes em polpas da graviola in natura e congelada e realizar uma revisão de trabalhos que justifiquem o uso da graviola na diminuição da proliferação do câncer. Foram identificadas quantidades bastante significativas de compostos fenólicos nas amostras de graviola, porém sem diferenciação do tratamento congelado ou in natura. Logo sugere seu uso na prevenção do câncer e necessitam de mais estudos para a sua utilização no tratamento de pacientes oncológicos. ABSTRACT Secondary Metabolitics Present at Annona Muricata L and Its Nutritional and Functional Properties in Oncology Functional nutrition has gained ground in recent years for its therapeutic action, especially the soursop fruit. Several well-conducted studies suggest that the fruit has considerable amounts of minerals, fiber, antioxidants and substances that act against cancer cells, highlighting the action of acetogenins. However it aimed to perform the quantification of the phenolic compounds present in soursop pulp of fresh and frozen and conduct a review of studies that justify the use of soursop in reducing cancer proliferation. They were identified fairly significant amounts of phenolic compounds in the samples of soursop, however no differentiation of treatment or frozen raw. Logo suggests its use in preventing cancer and need further studies for its use in the treatment of cancer patients.

  2. Total physical activity might not be a good measure in the relationship with HDL cholesterol and triglycerides in a multi-ethnic population: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    de Munter Jeroen SL

    2011-11-01

    Full Text Available Abstract Background Evidence suggests that physical activity (PA has a beneficial effect on high-density lipoprotein cholesterol (HDL and triglycerides. However, observational studies show contrasting results for this association between different ethnic groups. It is unclear whether this is due to differences in the PA composition. The aim of this study was to assess the relationship of the total PA, along with its intensity and duration, with HDL and triglycerides in a multi-ethnic population. Methods The study population was sampled from the SUNSET study and included: 502 European- Dutch, 338 Hindustani-Surinamese, and 596 African-Surinamese participants living in Amsterdam, the Netherlands. We assessed PA with the SQUASH questionnaire. We calculated age-sex-adjusted betas, geometric mean ratios (GMRs, and prevalence ratios (PRs to assess the relationship of PA with HDL and triglycerides. Results In the adjusted models, the highest total PA tertile compared to the lowest tertile was beneficially associated with HDL (beta: 0.08, 95% CI: 0.00, 0.16 and PR low HDL 0.59, 95% CI: 0.39, 0.88 and triglycerides (GMR: 0.93, 95% CI: 0.83, 1.03 and PR: 0.56, 95% CI: 0.29, 1.08 for the African-Surinamese. No statistically significant associations appeared for total PA among the European-Dutch and Hindustani-Surinamese. The adjusted models with the intensity score and HDL showed beneficial associations for the European-Dutch (beta: 0.06, 95% CI: 0.03, 0.10 and African-Surinamese (beta: 0.06, 0.02, 0.10, for log triglycerides for the European-Dutch (beta: -0.08, 95% CI: -0.12, 0.03, Hindustani-Surinamese (beta: -0.06, 95% CI: -0.16, 0.03, and African-Surinamese (beta: -0.04, 95% CI: -0.10, 0.01. Excepting HDL in African-Surinamese, the duration score was unrelated to HDL and triglycerides in any group. Conclusions Activity intensity related beneficially to blood lipids in almost every ethnic group. The activity duration was unrelated to blood lipids, while

  3. EFEITOS DA TERAPIA DE CONTENSÃO INDUZIDA ADAPTADA NA FUNCIONALIDADE E QUALIDADE DE VIDA DE PACIENTES HEMIPARÉTICOS

    OpenAIRE

    Palavro, Eliane Maria Biasibetti; Faculdade da Serra Gaúcha; Schuster, Rodrigo Costa; Faculdade da Serra Gaúcha

    2013-01-01

    Introdução: O acidente vascular encefálico (AVE) é um déficit neurológico resultante da interrupção sanguínea de uma determinada região encefálica. Ele pode gerar perdas motoras e funcionais e o indivíduo pode ser incapaz de usar o hemicorpo e/ou membro acometido. A reorganização cerebral consiste em mudanças na organização do córtex. Uma das técnicas fisioterapêuticas que vem se destacando é a Terapia por Contensão Induzida (TCI), que consiste em treinamento intensivo, prático e com repetiçõ...

  4. Alterações celulares, moleculares e funcionais de fígados de ratas Wistar tratadas com fatores hepatotróficos

    OpenAIRE

    Thiago Pinheiro Arrais Aloia

    2010-01-01

    Fatores hepatotróficos (FH) possuem a capacidade de promover aumento de massa hepática em ratos e diminuição da fibrose em animais cirróticos. Os FH podem ser importantes nos casos de ressecção e transplantes hepáticos no qual o fígado remanescente necessita de um volume considerável para exercer suas funções após a cirurgia. Objetivou-se neste trabalho avaliar a cinética de uma solução de FH em fígados de animais