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Sample records for fuerza ionica 2m

  1. Effect of the chloride ions on the hydrolysis of praseodymium in a 2M ion force media; Efecto de los iones cloruro sobre la hidrolisis del praseodimio en medio de fuerza ionica 2M

    Energy Technology Data Exchange (ETDEWEB)

    Lopez G, H.; Jimenez R, M.; Solache R, M.; Rojas H, A. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2004-07-01

    The constants of the product of solubility and the first of hydrolysis were determined of the Praseodymium in media 2M of NaClO{sub 4} and 2M of NaCl, to 303 K and under conditions free of CO{sub 2}. The diagram of solubility was obtained (pPr{sub (ac)} - pC{sub H}), by means of a radiochemical method and with it was established the pC{sub H} that limit the saturation and non saturation areas; that diagram allowed, also, to calculate the constant of the product of solubility. Also, it was adjusted with the polynomial of solubility equation, that it allowed to determine and to check the values of the constants of the product of solubility and the first of hydrolysis. Independently, it was determined the first constant of hydrolysis of the element, by means of potentiometric titrations whose data were treated with the computer program named SUPERQUAD and with the adjustment of the equation of the average number of bonds. It was also calculates the log constant {beta}{sub Pr,Cl} of the specie PrCI{sup 2+} starting from the hydrolysis constants obtained in the perchlorate and chloride media. (Author)

  2. Determination of formation constants of hydroxo carbonate complexes of Pr{sup 3+} in 2M NaCl at 303 K; Determinacion de las constantes de hidrolisis y de los complejos con carbonatos del Praseodimio (III), en medio de fuerza ionica 2M de cloruro de sodio, a 303 K

    Energy Technology Data Exchange (ETDEWEB)

    Lopez G, H D

    1997-12-31

    The hydrolysis of Praseodymium III in 2M sodium chloride at 303 K was studied. Two methods were used: pH titration followed by a computational refinement and solvent extraction in the presence of a competitive ligand. The hydrolysis constants obtained by pH titration were: log {beta}{sub 1,H} = -7.68 {+-} 0.07, log {beta}{sub 1,2H} = -15.10 {+-} 0.03, and {beta}{sub 1,3H} -23.8 {+-} 0.04. The stability constants of Praseodymium carbonates were determined by pH titration as well and were: log {beta}{sub 1,CO3}{sup 2-} = 5.94 {+-} 0.08 and log {beta}{sub 1,2CO3}{sup 2-} = 11.15 {+-} 0.15. Praseodymium carbonate species were taken into consideration for calculating the first hydrolysis constants by the solvent extraction method and the value obtained was: log {beta}{sub 1,H} = -7.69 {+-} 0.27. The values for log {beta}{sub 1,H} attained by both methods are the same. The species-distribution diagram was obtained from the stability constants of Praseodymium carbonates and hydrolysis products in the conditions of the present work. (Author).

  3. Effect of the ion force on the hydrolysis constants and of the solubility product of Europium; Efecto de la fuerza ionica sobre las constantes de hidrolisis y del producto de solubilidad del europio

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez R, M.; Ramirez G, J.J.; Solache R, M.; Rojas H, A. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2003-07-01

    A study on the behavior of the first hydrolysis constant {beta}{sub Eu,H}{sup l-0} and the constant of the solubility product Kps of the europium in front of the changes of the ion force: 0. 02 M, 0.1 M, 0.7M, 2M, 3M and 4M of sodium perchlorate, at 303 K. Experimentally the potentiometry and also radioactivity measures its were used. The specific interaction of ions theory (SIT) of Bronsted-Guggenheim-Scatchard allows the extrapolation of the values to infinite dilution and the results were: log {beta}{sub Eu,H}{sup l-0} = -7 36 and log K{sub sp}{sup l-0} = -24. 68. A discussion of the group of results with the data of the literature is presented. (Author)

  4. Fuerza primitiva y fuerza derivativa

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    Leonardo Ruiz

    2015-06-01

    Full Text Available La fuerza derivativa es descrita por Leibniz como modificación o limitación de la entelequia o fuerza primitiva. Sin embargo, la describe también como perteneciente a los fenómenos y como causante del movimiento físico. Algunos comentadores han encontrado en este punto un conflicto irresoluble dentro del sistema leibniziano, mientras que otros han ensayado algunas soluciones. Este artículo presenta un análisis de la noción de “modo”, tal como es utilizada en la descripción de la relación entre fuerza primitiva y fuerza derivativa. A partir de este análisis, realizaré una crítica de las lecturas de dos comentadores que tratan sobre este tema y trataré de dar, finalmente, una explicación de cómo la fuerza derivativa puede pertenecer a los fenómenos siendo, a la vez, una modificación de la entelequia. Esto puede ser de gran ayuda para comprender las relaciones entre metafísica y dinámica en la filosofía leibniziana.

  5. La fuerza normal: ¿una fuerza conservativa?

    OpenAIRE

    Díaz-Solórzano, S.; González-Díaz, L.

    2011-01-01

    La fuerza normal es una fuerza de ligadura que surge del contacto entre un objeto y una superficie. Esta fuerza puede conservar la energía mecánica de un sistema o no. Se muestra que dicha fuerza es conservativa cuando la superficie no evoluciona en el tiempo, así como la tasa a la cual varía la energía mecánica cuando la fuerza normal es no conservativa. Para esta última situación, se propone la función energía pseudo-potencial asociada a la fuerza normal con la finalidad de obtener la ecuac...

  6. Determination of the constants of the solubility product of Ln(OH){sub 3} and the effect of the chloride ions on the lanthanum hydrolysis, praseodymium and lutetium in aqueous solutions of ion force 2 Molar; Determinacion de las constantes del producto de solubilidad de Ln(OH){sub 3} y el efecto de los iones cloruro sobre la hidrolisis de lantano, praseodimio y lutecio en soluciones acuosas de fuerza ionica 2 Molar

    Energy Technology Data Exchange (ETDEWEB)

    Lopez G, H.D

    2005-07-01

    The behavior of lanthanum (III), praseodymium (III), and lutetium (III) was studied in 2 M NaClO{sub 4} (aq) and 2 M NaCl (aq) at 303 K and free -CO{sub 2} conditions. Solubility diagrams (p Ln(aq)-pC{sub H}) were obtained by means of a radiochemical method. The pC{sub H} borderlines of saturation and unsaturation zones of the solutions and solubility product constants for Ln(OH){sub 3} were determined from these diagrams. The fitting of the solubility equation to the experimental values of p Ln(aq)-pC{sub H} diagrams allowed the calculation of the first hydrolysis and solubility product constants. Independently, the stability constants for the first species of hydrolysis were determined by means of pH titrations, the data were treated with the program SUPERQUAD and fitted to the mean ligand number equation. The stability constants for the species LnCl{sup 2+} were as well calculated in 2M ionic strength and 303 K from the hydrolysis constant values obtained in both perchlorate and chloride media. The values obtained for La, Pr and Lu were: logK{sub ps}: 21.11 {+-} 0.09, 19.81 {+-} 0.11 and 18.10 {+-} 0.13 in 2M NaClO{sub 4}; logK{sub ps}: 22.22 {+-} 0.09, 21.45 {+-} 0.14 and 18.52 {+-} 0.29 in 2M NaCl; log {beta}{sub 1}: - 8.64 {+-} 0.02, - 8.37 {+-} 0.01 and - 7.95 {+-} 0.11 in 2M NaClO{sub 4}; log {beta}{sub 1}{sup /} : - 9.02 {+-} 0.11, - 8.75 {+-} 0.01 and - 8.12 {+-} 0.03 in 2M NaCl and the values for log {beta}{sub 1,Cl} were - 0.0255, - 0.155 and - 0.758, respectively. (Author)

  7. FUERZA DE LA LEY

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    Guido Leonardo Croxatto

    2015-09-01

    Full Text Available Se presenta un análisis de un texto de Jacques Derrida, Fuerza de la ley. El fundamento místico de la autoridad, en el cual el autor analiza, como indica el título del ensayo, los fundamentos (narraciones, e ideas en que se basa la autoridad del Derecho. Se busca cruzar el análisis que lleva adelante Derrida de las obras de autores como Pascal, Montaigne, Walter Benjamin, Kafka, con las preguntas actuales de la filosofía legal, como ser el basamento (meramente conjetural, hipotético, presupuesto de la norma fundamental de Kelsen o la vinculación entre el Derecho y la Moral, el Derecho y la Justicia, el Derecho y la violencia. El punto central a que se dedica el autor es interrogar el concepto de violencia. Trata de precisar quién, por qué y cómo detenta el máximo poder: el poder de nombrar qué es lo que es violento. Y qué es lo que no. “¿Que diferencia hay entre la fuerza de la ley y la mera violencia que consideramos injusta?” Esta es la pregunta fundamental que inspira el texto de Derrida, pero también es la pregunta que ha inspirado desde siempre a los abogados.

  8. Entrenamiento de fuerza para la salud

    OpenAIRE

    Ortiz Cervera, Vicente

    1996-01-01

    Este artículo describe de manera breve y clara los efectos del entrenamiento de fuerza sobre la salud, al mismo tiempo da pautas para la realización y programación de los entrenamientos de fuerza para la salud en distintas edades. Se muestran las diferentes variables del entrenamiento de la fuerza junto con ejemplos de entrenamientos, basándose en las pautas marcadas en la revisión bibliográfica descrita.

  9. Formas estructurales de fuerza constante

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    Zalewski, Waclaw

    1963-05-01

    Full Text Available The author seeks to prove the need to obtain the most essential form in the various types of structures by applying a number of rational principles, of which the constant stress principle is one of the most decisive. The structural form should be a logical consequence of all its functional circumstances, and this requires a clear understanding of the general behaviour of each part of the structure, and also of the main stresses which operate on it, considered as a unitary whole. To complete his theoretical argument, the author gives some examples, in the design of which the criterion of constant stress has been adopted. The author considers the various aspects which are involved in obtaining a structural design that satisfies given functional and aesthetic requirements. In doing so he refers to his personal experience within Poland, and infers technical principles of general validity which should determine the rational design of the form, as an integrated aspect of the structural pattern. The projects which illustrate this paper are Polish designs of undoubted constructive significance, in which the principle of constant stress has been applied. Finally the author condenses his whole theory in a simple and straightforward practical formula, which should be followed if a truly rational form is to be achieved: the constancy of stress in the various structural elements.El autor se esfuerza en mostrar la necesidad de llegar a la forma real en las distintas estructuras siguiendo una serie de principios racionales, entre los que domina el criterio de la fuerza constante. La forma ha de ser una consecuencia lógica en todos sus aspectos, y esto exige un claro conocimiento del comportamiento general de cada una de las partes de la estructura, y de los esfuerzos generales que dominan en la misma al considerarla como un todo. Para completar la exposición de orden teórico, el autor presenta algunos ejemplos en cuyo proyecto se ha seguido el criterio de

  10. Fuerza lumbar en jugadores de hockey hierba

    OpenAIRE

    Til Pérez, Lluís; Barceló Peiró, Oriol; Pomés Díes, Teresa; Martínez Navas, Roberto; Galilea Ballarini, Pedro; Bellver Vives, Montserrat

    2007-01-01

    Introducción: El dolor lumbar tiene una alta prevalencia entre los deportistas, se ha relacionado con déficits en la fuerza extensora lumbar, y el hecho de padecerlo representa un obstáculo importante para la práctica de deportes de alta intensidad. Método: Se ha medido la fuerza lumbar en 2 grupos de practicantes de hockey hierba mediante máquina MedX® y un test de resistencia isométrico lumbar. Resultados: Entre ambos grupos los resultados han sido muy homogéneos....

  11. NOVOSIBIRSK: VEPP-2M

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    The VEPP-2M electron-positron collider at the Budker Institute of Nuclear Physics in Novosibirsk began a new life after completion of the booster BEP and construction of two new detectors - CMD-2 and SND. The collider covers a collision energy range from the threshold of pion pair production up to 1.4 GeV. Although this energy range is far below the summits needed to produce Z and W bosons or the top quark, it can nevertheless provide important information for a better understanding of the Standard Model and beyond

  12. Ion nitriding post-oxidation as an alternative technique to electrolytic chromium; Nitruracion post-oxidacion ionica como tecnica alternativa al cromado electrolitico

    Energy Technology Data Exchange (ETDEWEB)

    Diaz-Guillen, J. C.; Granda-Gutierrez, E.E.; Campa-Castilla, A.; Perez-Aguilar, S.I.; Garza-Gomez, A.; Candelas-Ramirez, J.; Mendez-Mendez, R. [COMIMSA. Corporacion Mexicana de Investigacion en Materiales S.A. de C.V., Saltillo, Coahuila (Mexico)]. E-mail: jcarlos@comimsa.com

    2010-11-15

    The effect of temperature and processing time during post-oxidation on hardness and corrosion resistance of AISI 1045 samples treated through nitriding and post-oxidation in a pulsed plasma discharge is evaluated in this paper. Also, a comparative analysis of the mechanical properties obtained with the dual nitriding - post oxidation process versus those properties of typical hard chrome coatings was performed with an aim to propose an alternative technique to the processes of galvanic coatings. The latter revealed that the process of ion nitriding and post-oxidation provides similar properties in hardness and improves the corrosion resistance compared to the hard chrome case. It is conclude that the technique of ion nitriding and post-oxidation is a non environmental harmful technology with strong potential to replace highly polluting electroplating techniques for application of hard chrome coatings. [Spanish] En el presente trabajo se evalua el efecto del tiempo y la temperatura de post-oxidacion sobre las propiedades de dureza y resistencia a la corrosion de muestras de acero AISI 1045 sometido al proceso de nitruracion post-oxidacion ionica en plasmas pulsados. Asi mismo, con el objetivo de fundamentar la propuesta de utilizacion de la nitruracion post-oxidacion ionica como una tecnica alternativa a los procesos galvanicos para aplicacion de recubrimientos de cromo duro, se realizo un analisis comparativo de propiedades, evidenciando que, mediante el proceso nitruracion postoxidacion ionica, es posible obtener caracteristicas similares en dureza y mejores en resistencia a la corrosion que las tipicas obtenidas para el cromo duro. Los resultados obtenidos permiten postular una tecnica que no dana al medio ambiente, como lo es la nitruracion post-oxidacion ionica, como candidata potencial para sustituir las tecnicas galvanicas altamente contaminantes para aplicacion de cromo duro.

  13. Fuerza manual de adultos con discapacidad intelectual

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    Ruth Cabeza Ruiz

    2017-09-01

    Full Text Available Objetivo. Presentar una descripción de la fuerza de prensión manual de hombres y mujeres con discapacidad intelectual (DI y comparar los resultados con valores de referencia de otras personas con y sin discapacidad intelectual. Método. El presente trabajo es un estudio transversal observacional, financiado por la Fundación SAMU, en el que se evaluaron a 122 personas con DI (86 hombres y 36 mujeres durante el desarrollo de unas jornadas de carácter recreativo en las que participaron varias asociaciones de atención a este colectivo. La batería de test utilizada fue el Alpaha-Fit Test Battery for Adults. Resultados. Se presentan los resultados relacionados con las variables de fuerza del miembro superior (Hand Grip Strength por grupos de edad (20-24, 25- 29, 30-34, 35-39, 40-44, 45-49, 50-54, 55-59 años. Los datos muestran valores que oscilan desde los 31 kg en los hombres más jóvenes con DI hasta los 13.3 kg del grupo más maduro de mujeres. Estos hallazgos son similares a los valores de referencia de población con DI española. Sin embargo, son muy inferiores a los obtenidos por la población sin discapacidad de la misma edad. Conclusión. Los resultados evidencian el menor rendimiento de las personas con DI en pruebas de fuerza de prensión manual por lo que se hace evidente la necesidad de llevar a cabo programas de ejercicio físico o deporte con las personas con DI.

  14. El entrenamiento de fuerza en la natación

    OpenAIRE

    Irigaray Martín, Javier

    2014-01-01

    Existen numerosos estudios que demuestran la importancia del entrenamiento de fuerza en la mejora del rendimiento en la natación. El objetivo del entrenamiento de fuerza en natación es por tanto buscar la transferencia en rendimiento de la natación de competición. Sin embargo, aunque los estudios hayan mostrado mejoras significativas con el entrenamiento de fuerza, no se ha demostrado que exista una transferencia específica. No obstante, su introducción en el programa de ent...

  15. Entrenamiento de la fuerza en el fútbol

    OpenAIRE

    Olivares Ruiz, Alejandro

    2014-01-01

    El “Entrenamiento de la Fuerza en el Fútbol” consta de cuatro capítulos: en un primer punto, conoceremos los objetivos que persigue este trabajo, que son, resumidamente, analizar la importancia del entrenamiento de la fuerza en el fútbol, saber qué manifestación de la fuerza conviene más trabajar en este deporte, y conocer y comparar las metodologías de entrenamiento más utilizadas. Por otro lado, en este primer apartado también se argumentará por qué debe trabajarse esta cuali...

  16. Entrenamiento de fuerza y salud pediátrica

    OpenAIRE

    Faigenbaum, Avery D.; Myer, Gregory D.

    2011-01-01

    Aunque muchos médicos y jóvenes entrenadores consideran que el entrenamiento de fuerza es potencialmente peligroso e inseguro para el sistema músculo esquelético en desarrollo, una gran cantidad de evidencias científicas indican que este tipo de entrenamiento es seguro, efectivo y constituye una metodología adecuada para niños y jóvenes siempre que se sigan las indicaciones apropiadas. Los programas de entrenamiento de fuerza para niños y jóvenes, si son adecuadamente diseñados y supervisados...

  17. Fuerza de ventas determinante de la competitividad empresarial

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    Noelia Isabel León Valbuena

    2013-01-01

    Full Text Available El objetivo de este artículo es describir como la fuerza de ventas influye dentro y fuera de la organización empresarial para alcanzar la competitividad. Para ello se vincula la labor de la fuerza de ventas en la cadena de valor, y se estudia este importante eslabón de la cadena. La metodología utilizada es documental o bibliográfica. Se parte del supuesto de que la fuerza de ventas es la encargada de interrelacionar el entorno interno y externo de la organización, produciendo el ingreso necesario para el inicio y fin del ciclo productivo, a través de la realización de diversas actividades. Se concluye que para alcanzar los objetivos empresariales y la competitividad, es vital contar con una excelente fuerza de ventas; representativa de un factor de cambio y diferenciación de las organizaciones hacia el logro y permanencia de una empresa competitiva.

  18. Ionic propulsion; Propulsion ionica

    Energy Technology Data Exchange (ETDEWEB)

    Velarde, G

    1972-07-01

    The inner parameters (electrons and ions velocity, current, thrust, power; specific impulse) and the outer parameters (velocity and operating time) of an ion propellant rocket are studied. The components (chamber dimensions, weights, propellants,) are also described. (Author) 5 refs.

  19. Propuestas para el entrenamiento combinado de fuerza y resistencia

    OpenAIRE

    López de Viñaspre, Pablo; Comellas, Josep

    2000-01-01

    Muchas especialidades deportivas requieren de un buen nivel de entrenamiento tanto en la capacidad de fuerza como en la de resistencia. Por este motivo, se incluye el entrenamiento combinado de estas dos cualidades en el programa de entrenamiento de muchos deportistas. Por otro lado, en el deporte recreativo, el concepto del Fitness es ya común entre la mayoría de la población y va tomando cada vez más importancia. Actualmente se busca el bienestar global (tendencia del Wellness) a través de ...

  20. La modernización de las Fuerzas Armadas

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    Serra, Eduardo

    2014-02-01

    Full Text Available This article briefly reviews the recent history of the Spanish Armed Forces, stressing the importance of the military institution and its role in contemporary Spanish history. Following Franco’s death there was an attempt to bring the command of the Armed Forces under democratic control within the constitution, a process in which General Gutiérrez Mellado played a crucial role. Since 1981, two important measures have been taken in the military sphere: “case 2/81”, prosecuting the perpetrators of the attempted coup in 1981, and Spain’s application to join the Atlantic Alliance (NATO, a very important step in shaping the country’s future and driving the modernisation of the Spanish Armed Forces, putting them on an equal footing with their peers elsewhere in the Western world. After the socialist victory in 1982, the PSOE government changed direction, skilfully transforming its initial anti-Americanism, obtaining Spain’s membership of NATO following the 1986 referendum, and profoundly changing the Armed Forces, thus eliminating military tensions. The last stage of the modernisation process was led by Aznar’s government, with the professionalisation of the Armed Forces and the integration of Spain in NATO’s military structure.El artículo realiza un breve repaso por la historia de las Fuerzas Armadas españolas destacando la importancia de la institución militar y su papel en la Historia contemporánea española. Desde de la muerte de Franco se intenta por encauzar a los mandos de las Fuerzas Armadas en la senda democrática y constitucional, siendo entonces crucial el papel del General Gutiérrez Mellado. A partir de 1981, se toman dos importantes medidas en la esfera militar: la llamada causa 2/81, para el enjuiciamiento de los responsables de la intentona golpista y la solicitud de ingreso de España en la Alianza Atlántica, paso muy importante que determinará el futuro del país y permitió la modernización de las Fuerzas

  1. Elecciones presidenciales peruanas 2016: La fuerza del antifujimorismo

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    Andrés Ernesto Ferrari Haines

    2016-09-01

    Full Text Available El presente artículo analiza el proceso electoral presidencial peruano del año 2016. La segunda vuelta electoral fue disputada entre Pedro Pablo Kuczynski y Keiko Fujimori Higuchi. Fujimori Higuchi es hija del ex-presidente Alberto Fujimori quien cumple una condena de 25 años en prisión por violación a los derechos humanos y corrupción. En este análisis se destaca el papel que ejerció la izquierda peruana en el triunfo de Pedro Pablo Kuczynski. Diversas fuerzas políticas junto con una gran movilización ciudadana se manifestaron a favor de la candidatura de Kuczynski como una muestra del voto antifujimorista.

  2. The distribution systems of the Luz y Fuerza del Centro; Sistemas de distribucion en Luz y Fuerza del Centro

    Energy Technology Data Exchange (ETDEWEB)

    Espinosa y Lara, Roberto [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

    1997-12-31

    In this document are described the distribution systems that have been utilized in Mexico, to satisfy the electric energy demand. Mention is made of the areas of influence these systems have, its structure, the electric infrastructure that Luz y Fuerza del Centro has to satisfy the demand and in this way be in position of planning the distribution networks. As in other activities the aspects related to the protection of the environment exert a growing influence on the development of the energy sector, for this reason three themes are mentioned to which special attention must be paid. A table is shown with the per capita consumption, another one with the number of transformers and its capacity. Also the underground networks in operation and under construction are shown and a flow diagram of the distribution system planning [Espanol] En este documento se describen los sistemas de distribucion que se han realizado en Mexico, para satisfacer la demanda electrica, se mencionan las areas de influencia que tienen estos sistemas, su estructuracion, la infraestructura electrica con la que cuenta Luz y Fuerza del Centro para satisfacer las demandas y asi poder planear las redes de distribucion. Como en otras actividades, los aspectos relacionados con el cuidado del ambiente ejercen una influencia creciente sobre el desenvolvimiento del sector de energia, es por eso que se mencionan tres temas a los que se les debe de poner especial atencion. Se muestra una tabla de consumo per capita, otra del numero de transformadores y su capacidad. Tambien se ilustran las redes subterraneas en operacion y construccion y un flujograma de planeacion del sistema de distribucion

  3. Déficit bilateral de las manifestaciones de la fuerza muscular de las extremidades inferiores en estudiantes universitarios

    OpenAIRE

    Ramón Candia-Luján; Karen Ileana Carreón Santa Cruz; Beatriz Anai Núnez Escudero; Lidia Guillermina De León Fierro; Claudia Esther Carrasco Legleu

    2018-01-01

    El objetivo del estudio fue determinar el déficit bilateral (DBL) de las manifestaciones de la fuerza muscular de los miembros inferiores en estudiantes universitarios, participaron16 hombres y 14 mujeres. Se les evaluó la fuerza máxima dinámica, la potencia muscular y la fuerza isométrica, en forma bilateral y unilateral de ambas extremidades inferiores. La suma de la fuerza máxima dinámica unilateral de las extremidades inferiores fue mayor que la fuerza bilateral 132,4 ± 38,1 kg y 114,6 ± ...

  4. Estudio de los efectos del envejecimiento en la fuerza muscular y en el equilibrio

    OpenAIRE

    Barrena Aizcorbe, Oihane

    2011-01-01

    Objetivos: -Identificar cambios en la fuerza (máxima isométrica y explosiva) y en el equilibrio dinámico de las extremidades inferiores en las articulaciones de (caderas, rodilla y tobillo) entre los jóvenes y las personas mayores. -Determinar la relación existente la disminución de la fuerza a nivel de las extremidades inferiores y del equilibrio asociados a la edad. Material y métodos: Se ha realizado un estudio descriptivo transversal para determinar la fuerza máxima isométrica y explosiva...

  5. Programación del entrenamiento de la fuerza en el voleibol juvenil

    OpenAIRE

    Kolevich, Alejandro

    2011-01-01

    El trabajo intentará abordar las manifestaciones de la fuerza que predominan durante un partido de voleibol de nivel de liga nacional. Así pues, se buscará caracterizar el deporte y analizar los tiempos de juego, para poner en consideración si las fuerzas que aparecen son las más recomendadas a desarrollar con entrenamiento de sobrecarga o si resultaría necesario trabajar otra manifestación de la fuerza que no aparece en el juego mismo. De esta forma, la programación del ejercicio mostr...

  6. On the 2m 2m 2m-th power mean of Dirichlet L-functions with the ...

    Indian Academy of Sciences (India)

    The main purpose is to use the analytic method to study the 2 m -th power mean of Dirichlet -functions with the weight of the general trigonometric sums and give ... School of Science, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, People's Republic of China; The School of Electronic and Information Engineering, Xi'an ...

  7. Simuladores para entrenamientos en la Fuerza Aérea Colombiana

    Directory of Open Access Journals (Sweden)

    José Fernando Sizza Moreno

    2014-01-01

    Full Text Available La simulación es una técnica que compromete ingeniería de software, ingeniería mecánica e ingeniería electrónica, además de emulación, que definen los modelos matemáticos para dotar a una máquina especificaciones funcionales, para la apariencia en tiempo real de comportamientos idénticos a los de su contraparte a imitar. Asimismo, emular es una reproducción de las operaciones de otro, intentando igualarlas e incluso excederlas. De esta manera, una máquina se dota con la simulación y la emulación en tiempo real, diseñando máquinas capaces de imitar y remedar otras, sin los riesgos, humanos o de infraestructura que involucra en la realidad, con la emulación acorde con la máquina a igualar. El entrenamiento puede ejecutarse en este tipo de máquinas, para proporcionar y evaluar las habilidades necesarias a desarrollarse en la vida real, con el fin de disminuir los costos y los tiempos que implican. Es así que el objetivo de este artículo es proporcionar una visión sobre simuladores aeronáuticos puestos en práctica en la Fuerza Aérea Colombiana.

  8. ECR heating in L-2M stellarator

    International Nuclear Information System (INIS)

    Grebenshchikov, S.E.; Batanov, G.M.; Fedyanin, O.I.

    1995-01-01

    The first results of ECH experiments in the L-2M stellarator are presented. The main goal of the experiments is to investigate the physics of ECH and plasma confinement at very high values of the volume heating power density. A current free plasma is produced and heated by extraordinary waves at the second harmonic of the electron cyclotron frequency. The experimental results are compared with the numerical simulations of plasma confinement and heating processes based on neoclassical theory using the full matrix of transport coefficients and with LHD-scaling. 4 refs., 2 figs

  9. ¿La fuerza puede predecir el rendimiento y la lesionabilidad en el baloncesto profesional?

    Directory of Open Access Journals (Sweden)

    Toni Caparrós Pons

    2014-12-01

    Full Text Available Con el objetivo de conocer las relaciones existentes entre la fuerza, el rendimiento deportivo y la lesionabilidad en un equipo masculino de baloncesto profesional, se realiza un estudio prospectivo, observacional y descriptivo de análisis de estadísticas (71 partidos, test de media sentadilla (n = 7 y patología lesional, monitorizando la temporada 09/10, donde se relacionan los datos obtenidos de cada jugador referentes al rendimiento deportivo por partido (valoración estadística, las medias de fuerza, velocidad y potencia de cada mesociclo y la lesionabilidad. La técnica estadística utilizada ha sido la correlación a partir del parámetro rho de Spearman. Estas correlaciones entre fuerza y lesionabilidad muestran que a valores de fuerza más elevados hay más lesiones: con 80 kg son muy significativas para lesiones totales (LT y potencia (rho = 0,898; p = 0,006, y significativas por fuerza (rho = 0,823; p = 0,023 y velocidad (rho = 0,774; p = 0,041; la velocidad con 90 kg se relaciona con lesiones time loss (TL (rho = 0,878; p = 0,009, y la potencia con 100 kg, con lesiones totales (LT (rho = 0,805; p = 0,029 y V100 (rho = 0,898; p = 0,006 muy significativamente. En conclusión, durante la ejecución de la media sentadilla, hay valores de fuerza acordes para rendir más y lesionarse menos: de 800 N a 1050 N y con cargas de 80 kg a 90 kg.

  10. Efectos de un programa de entrenamiento de fuerza sobre la composición corporal y la fuerza máxima en jóvenes entrenados

    OpenAIRE

    Torres Luque, Gema; Ponce de León, Facundo; Orquín Castrillón, Francisco Javier

    2009-01-01

    El objetivo de este estudio fue conocer las adaptaciones en composición corporal, fuerza máxima y resistencia muscular local de un programa de entrenamiento de fuerza en circuito intermitente con sobrecargas. Método: Se seleccionaron 8 varones jóvenes entrenados en musculación (24,07 ± 3,12 años, 77,96 ± 7,5 kg, 173 ± 0,2 cm y 14,50 ± 2,00 meses de experiencia). Todos los sujetos firmaron un consentimiento por escrito de participación. Se realizó una valoración antropométrica, 10 tests de ...

  11. Efectos de un programa de entrenamiento de fuerza sobre la composición corporal y la fuerza máxima en jóvenes entrenados

    OpenAIRE

    Torres Luque, Gema; Orquín Castrillón, Francisco; Ponce de León, Facundo

    2009-01-01

    El objetivo de este estudio fue conocer las adaptaciones en composición corporal, fuerza máxima y resistencia muscular local de un programa de entrenamiento de fuerza en circuito intermitente con sobrecargas. Método: Se seleccionaron 8 varones jóvenes entrenados en musculación (24,07 ± 3,12 años, 77,96 ± 7,5 kg, 173 ± 0,2 cm y 14,50 ± 2,00 meses de experiencia). Todos los sujetos firmaron un consentimiento por escrito de participación. Se realizó una valoración antropométrica, 10 tests de una...

  12. RELACIÓN ENTRE DIFERENTES PRUEBAS DE CAMPO: FUERZA, POTENCIA Y VELOCIDAD

    OpenAIRE

    Jessenia Hernández Elizondo

    2003-01-01

    Esta investigación tuvo como propósito principal el encontrar por medio de pruebas en las variables de fuerza, potencia y velocidad, la relación matemática existente entre estos tres constructos. Participaron 56 sujetos varones con edades entre 18 y 25 años. Con el fin de responder al objetivo del estudio, se les aplicaron pruebas de campo de fuerza (1RM de sentadilla completa y repeticiones máximas al 80% 60% 40% y 20%), de velocidad (30 metros lanzados y 30 metros sin impulso), y de potenci...

  13. Control de las fuerzas de fresado mediante actuadores piezoeléctricos

    OpenAIRE

    Diez Cifuentes, Eduardo

    2010-01-01

    Resumen El alabeo de la herramienta y sus efectos constituyen una importante línea de investigación dentro del modelado, simulación y control de fuerzas de corte en fresado. El alabeo de la herramienta hace que los filos corten de manera desigual, por lo que las fuerzas de corte sobre cada filo resultan diferentes. Esto afecta la vida de la herramienta y deteriora la calidad superficial de la pieza. En este trabajo se propone un procedimiento para disminuir los efectos del alabeo de la herram...

  14. Fuerzas Ortodóncicas como Agentes Vulnerantes de la Salud Pulpar: Reporte de Dos Casos

    OpenAIRE

    Fonseca, Gabriel M; Guzmán, Andrés E

    2010-01-01

    La literatura ya ha sugerido la implicancia del uso de fuerzas ortodóncicas como productoras de daño mecánico, reacción inflamatoria periodontal, lesión periapical y reabsorción radicular. Los parámetros más comúnmente explorados en investigaciones de la respuesta tisular a fuerzas ortodónticas consisten en medir los niveles de oxígeno pulpar, la vasculatura y los cambios en la circulación sanguínea. Se ha demostrado que la irrigación pulpar disminuye tempranamente cuando se realizan aplicaci...

  15. Ajuste de la fuerza de infección del dengue

    OpenAIRE

    Aldana-Bermúdez, Eliécer; Restrepo-Triviño, Maribel; Muñoz-Loaiza, Aníbal

    2017-01-01

    RESUMEN Objetivo Plantear un modelo matemático hospedero vector para el ajuste de la fuerza de infección del dengue en una población variable con crecimiento logístico y ciclo de vida del mosquito con tasa de ovoposición periódica, considerando inmunidad a un serotipo. Métodos El modelo matemático propuesto está representado por ocho ecuaciones diferenciales a las que se les calcula la fuerza de infección por el método de las redes libres de escala. Resultados Se presenta una simulación...

  16. Apocalissi teosofiche in Las fuerzas extrañas di Leopoldo Lugones

    Directory of Open Access Journals (Sweden)

    Camilla Cattarulla

    2013-06-01

    Full Text Available In 1906 the Argentinian author Leopoldo Lugones published Las fuerzas extranas. In this collection of short stories Lugones places his interests in spiritism and science at the service of fiction and modernist prose. Lugones furthermore embraces aesthetically the theosophic doctrine envisaging a quest for absolute perfection through a process of renewal and reincarnation of the individual; it is within this framework that a number of apocalyptic episodes found in Las fuerzas extrañas are to be interpreted, pointing as they do in an intertextual game to specific Biblical passages which illustrate the theosophic stand of the author.

  17. Entrenamiento de la fuerza en la mujer= Strength trainning in women

    OpenAIRE

    Garc??a del Castillo, Diego

    2016-01-01

    Este trabajo de revisi??n bibliogr??fica sobre el entrenamiento de la fuerza en las mujeres, va encaminado a concienciar de la igualdad que existe en los efectos y beneficios que ambos sexos. Estas falsas creencias son producto de y que a??n perduran en la actualidad de forma injustificada. Por tanto e trabajo es conseguir establecer en la sociedad entrenamiento de la fuerza causa en la figura entre sexos para poder relacionar conceptos y aclarar estos mitos de los que ha...

  18. Planificación del entrenamiento de fuerza en natación

    OpenAIRE

    Pérez de Blas, Laura

    2014-01-01

    La principal función del siguiente trabajo es facilitar el proceso de diseño de un programa de entrenamiento de fuerza para nadadores, mediante la exposición de los diferentes aspectos a tener en cuenta en dicho proceso, y la propuesta de un ejemplo de programación. El trabajo de fuerza forma parte integrada del entrenamiento de nadadores para diferentes edades y niveles, pero por las características especiales en las que se desarrolla este deporte, se hace preciso un conoci...

  19. The evolution of the Luz y Fuerza del Centro substations. Volume 2; Evolucion de las subestaciones de Luz y Fuerza del Centro. Volumen 2

    Energy Technology Data Exchange (ETDEWEB)

    Carranza Ramirez, Sergio [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

    1997-12-31

    This document cites historical background of how the Luz y Fuerza del Centro substations have evolved up to nowadays. A brief description is made of one electric substation, the substation design criteria are mentioned, since it must comply with the requirements of reliability, service continuity, service quality, economy, geographical location, just for mentioning some of them. The more utilized arrangements of the Luz y Fuerza del Centro substations are described. In the same manner, the remote control substations are described mentioning the main elements of this type of substations. Mention is made also of the technological incorporations that have been made to the substations and the perspectives there are from these. One line diagrams of the electric substations are shown, as well as from power plant substations [Espanol] Este documento cita antecedentes historicos de como han evolucionando las subestaciones de Luz y Fuerza del Centro hasta hoy en dia. Se realiza una breve descripcion de una subestacion electrica, se mencionan los criterios de diseno de una subestacion, ya que debe cumplir con los requisitos de confiabilidad, continuidad, calidad del servicio, economia, situacion geografica, por mencionar algunos de estos. Se describen los arreglos de las subestaciones mas utilizados por Luz y Fuerza del Centro. De igual manera se describen las subestaciones telecontroladas mencionando los principales elementos de este tipo de subestaciones. Se mencionan las incorporaciones tecnologicas que se han realizado a las subestaciones y las perspectivas que se tienen de estas. Se muestran diagramas unifilares de subestaciones electricas, al igual que se muestran las plantas de las subestaciones

  20. Manual de entrenamiento de la fuerza en el fútbol. La planificación del trabajo de fuerza en un equipo

    OpenAIRE

    Ruiz Madrid, Álvaro

    2014-01-01

    En este proyecto final de grado se va a conceptualizar la importancia del entrenamiento de la fuerza en un equipo de fútbol actualmente, así como los diferentes métodos de trabajo y sus consecuencias. Seguidamente veremos un ejemplo de planificación de una temporada de fútbol realizando un estudio previo de la entidad y posteriormente el desarrollo de la planificación.

  1. Efectos de un entrenamiento concurrente de fuerza y resistencia sobre carreras de media distancia

    Directory of Open Access Journals (Sweden)

    Juan Manuel García-Manso

    2017-01-01

    Full Text Available El objetivo de este estudio fue evaluar los efectos del entrenamiento concurrente (fuerza y resistencia sobre las carreras de media distancia en sujetos jóvenes de moderado nivel de rendimiento. Se aplicó un trabajo organizado en fases de diferente orientación de fuerza, lo que se conoce como periodización por bloques. Quince universitarios sanos y físicamente activos participaron voluntariamente en el estudio. Fueron organizados aleatoriamente en dos grupos: uno que entrenaba solo resistencia (Grupo Resistencia: GR: Edad=21.3±2.3 años; Peso Corporal=66.8±1.9 kg; Estatura=172.0±2.3 cm; Grasa Corporal=10.8±1.1% y otro (Grupo Fuerza-Resistencia: GFR: Edad=20.9±1.2 años; Peso Corporal=69.8±1.3 kg; Estatura=172.8±3.9 cm, Grasa Corporal=11.4±0.6% al que se le añadió un protocolo de entrenamiento de fuerza de 9 semanas (2 días/semana de duración. No se detectaron grandes diferencias en los cambios observados en ambos grupos al final de las nueve semanas. Los dos grupos mejoraron significativamente su rendimiento en las carreras de media y larga duración, la fuerza, la resistencia de fuerza y su capacidad aeróbica (VO2 max. Los cambios fueron poco apreciables en el resto de las pruebas evaluadas (60 y 300 metros. Los mayores beneficios se encontraron en la carrera de 2000 metros. Dichas mejoras se detectaron desde el primer mesociclo de entrenamiento y fueron especialmente evidentes al final de las nueve semanas. No obstante, no se detectaron diferencias relevantes entre ambos grupos (6.5±3.7 vs. 3.7±2.1 ml/kg/min; F=0.534; IC95%= -0.198, 5.932; p=0.65; ES=0.434. En conclusión, podemos afirmar que en esta muestra incorporar un trabajo de fuerza no conlleva mayores beneficios que entrenar solo la carrera.

  2. M2M Optimizations in Public Mobile Networks

    NARCIS (Netherlands)

    Norp, A.H.J.; Landais, B.

    2012-01-01

    Many M2M applications use public telecommunications networks to transfer data from M2M devices to an M2M server. These telecommunications networks will have to be adapted to cope with the traffic generated by the projected growth of M2M applications. In the near future, many more devices will be

  3. Electroestimulación neuromuscular intradiálisis, fuerza muscular, capacidad funcional y composición corporal

    Directory of Open Access Journals (Sweden)

    Sandra Rubio Páez

    2015-12-01

    Full Text Available Introducción: La capacidad funcional disminuida y la importante atrofia muscular caracterizan a los pacientes en hemodiálisis (HD. El ejercicio físico intradiálisis y recientemente la electroestimulación neuromuscular (EMS, representan dos serias opciones terapéuticas para mejorar esta deteriorada condición física. Actualmente, no existen estudios publicados sobre el papel de la EMS y la composición corporal en los pacientes en HD. Objetivo: Analizar que efecto produce un programa de EMS sobre la fuerza muscular, capacidad funcional, parámetros nutricionales y composición corporal en nuestros pacientes en HD. Material y Métodos: Estudio unicéntrico, prospectivo de 12 semanas de duración. Los pacientes incluidos realizaron un programa adaptativo de EMS en ambos cuádriceps intradiálisis mediante el dispositivo Compex R Theta 500i. Analizamos: 1.- Parámetros nutricionales (Albumina, pre albúmina, triglicéridos, colesterol total y fracciones, ferritina y Proteína C reactiva. 2.- Datos musculares: Composición muscular cuadriceps, Fuerza extensión máxima cuádriceps (FEMQ y handgrip (HG brazo dominante. 3.- Test funcionales: "Sit to stand to sit" (STS10 y "six-minutes walking test" (6MWT. 4.- Composición corporal mediante biompedancia electrica (BIA. Resultados: 13 pacientes incluidos: (69.2% hombres. Edad media: 65.7 años y 33.9 meses en HD. I.Charlson medio 9.1. La principal etiología de la ERC fue la DM (38.5%. Al final del estudio se observó una mejoría en (*p<0.05: FEMQ* (11.7±7.1 vs 13.4±7.4 Kg, STS10 (39.3±15.5 vs 35.8±13.7 seg, 6MWT* (9.9%, 293.2 vs 325.2 m. En relación a la composición corporal, se observó únicamente un aumento significativo del área muscular (AMQ*: 128.6 ± 30.2 vs 144.6 ± 22.4 cm² y una disminución del área grasa (AGQ*: 76.5 ± 26.9 vs 62.1 ± 20.1 cm² a nivel quadricipital, sin cambios en el resto de datos analizados (% grasa abdominal, peso graso, peso magro, agua corporal total

  4. Estimación de la fuerza de contacto para el control de robots manipuladores con movimientos restringidos

    Directory of Open Access Journals (Sweden)

    Javier Gámez García

    2007-01-01

    Full Text Available Resumen: En aquellas operaciones robóticas en las que un robot manipulador interactúa con su entorno resulta de extremada importancia poder controlar la fuerza que aquél ejerce sobre este. Con este objetivo, se suele colocar habitualmente un sensor de fuerza en la muñeca del manipulador, cerrando de esta forma el lazo de control. En lo que se refiere a estos sensores, uno de los principales problemas que plantean es que sus medidas están influenciadas no sólo por las fuerzas de contacto, sino también por las fuerzas relacionadas con la dinámica de la herramienta del manipulador, es decir, las fuerzas de inercia. En este artículo se presenta un nuevo estimador de la fuerza de contacto consistente en la integración de la información de sensores de fuerza, posición y aceleración. Además, se describe un procedimiento de calibración automático ‘plugand-play’ para la identificación y ajuste de los parámetros de este observador. Tanto el observador de la fuerza de contacto como el procedimiento de calibración automático han sido verificados experimentalmente en un robot industrial ABB con arquitectura software abierta. Palabras clave: Control de fuerza en robots manipuladores, Fusión sensorial, Observadores, Calibración Automática

  5. Estudio de la influencia de un programa de entrenamiento de la fuerza en diferentes factores de rendimiento, en jugadores de golf de ??lite

    OpenAIRE

    ??lvarez Plaza, Mar??a

    2011-01-01

    157 p. El prop??sito del presente estudio es determinar los efectos de un programa de entrenamiento de fuerza de 18 semanas de duraci??n, dividido en tres partes, sobre las caracter??sticas antropom??tricas, la fuerza explosiva de las extremidades inferiores, rendimiento con el drive, la fuerza m??xima y la fuerza isom??trica de agarre (grip) en jugadores de ??lite masculinos. La hip??tesis es que, tras el programa de entrenamiento de fuerza, de 18 semanas de duraci??n, real...

  6. Efectos de diferentes protocolos de entrenamiento de fuerza sobre la fuerza máxima, la velocidad, la saltabilidad y el equilibrio en estudiantes universitarios

    OpenAIRE

    Naclerio Ayllón, Fernando José; Marín, Pedro J.; Viejo Romero, David; Forte Fernández, Daniel

    2007-01-01

    El objetivo de este estudio es comparar los efectos de tres medios de entrenamiento sobre la fuerza máxima, la saltabilidad, la velocidad y el equilibrio en 24 varones estudiantes universitarios (21.5 ±1.7 años, 1.72± 0.06 m y 75.5±8.7 kg) que entrenaron durante 6 semanas con una frecuencia de 3 veces por semana, realizando 3 ejercicios: sentadilla paralela (SP), split frontal (SF) y extensiones de cadera (EC), siguiendo una periodización creciente-decreciente. Los sujetos fueron divididos en...

  7. Evaluación del desempeño de la fuerza de ventas

    OpenAIRE

    Rivera Camino, Jaime; Molero Ayala, Víctor

    1997-01-01

    Este artículo presenta la aplicación de una metodología nueva (Delphi Goal y Data Envelopment Analysis) para buscar la solución de un problema antiguo: la evaluación del desempeño de la fuerza de ventas. Nuestra propuesta teórica se presenta como una guía para las investigaciones que buscan enriquecer el conocimiento sobre el desempeño de la fuerza de ventas. Aunque el reconocimiento de la problemática de la evaluación de ventas no es nuevo, los métodos tradicionales tienden a evaluar el dese...

  8. Strategi Counterinsurgency Kolombia terhadap Farc (Fuerzas Armadas Revolucionarias De Colombia) 2010-2012

    OpenAIRE

    Olivia, Yessi; Miranda, Dea

    2014-01-01

    This paper is analysing about counterinsurgency Colombia to against paramilitary group in Colombia to help address the humanitarian crisis that occurred because of civil conflict in Colombia. Conflict in Colombia involving the Fuerzas Armadas Revolucionaries de Colombia (FARC) and the Government of Colombia is one example of a threat to human security in this case is a citizen of Colombia. Thousands of people confirmed dead, and hundreds more injured and displaced into the surrounding area. C...

  9. Efectos del entrenamiento de fuerza con distintas intensidades relativas y nivel de rendimiento inicial sobre las respuestas neuromuscular y hormonal

    OpenAIRE

    Otero Esquina, Carlos

    2017-01-01

    Programa de Doctorado en Actividad Física, Rendimiento Deportivo y Salud El objetivo de la presente tesis doctoral fue comprobar los efectos de dos tipos de entrenamiento de fuerza distintos en intensidad e igualados en volumen en el ejercicio de sentadilla completa sobre la respuesta neuromuscular y hormonal. Para ello se realizaron 3 estudios en los que se analizaron: Estudio 1: Efectos del entrenamiento de fuerza con distintas intensidades sobre la mejora en la capacidad de salto, e...

  10. Dramatic Rewritings of the Spanish Golden Age Theater of Cervantes´s La fuerza de la sangre

    Directory of Open Access Journals (Sweden)

    Juan Manuel Escudero Baztán

    2013-12-01

    Full Text Available This paper analyzes the Golden age spanish theater recreations of Cervantes’s exemplary novel La fuerza de la sangre. Specifically, the paper reviews three important stages in these recreations: La fuerza de la sangre of Guillen de Castro, El agravio satisfecho de Castillo Solórzano, and No hay cosa como callar de Calderon de la Barca. Different rewrites indicate a close relationship between the three dramatic texts through intertextuality and other influences.

  11. Atribuciones sobre el uso de la fuerza policial desde la perspectiva del agente

    Directory of Open Access Journals (Sweden)

    Julián Martínez

    2014-08-01

    Full Text Available Se describen los contenidos de los procesos atribucionales asociados al uso de la fuerza en agentes de la Policía de la Provincia de Córdoba, Argentina. Los antecedentes indican que, además de los marcos legales, existen sistemas de creencias, valores, actitudes, definiciones morales, aspectos situacionales y una cultura institucional, que operan en los policías al momento de usar la fuerza. Mediante entrevistas en profundidad a 10 agentes policiales de la Provincia de Córdoba, hallamos dimensiones atributivas externas e internas, que a su vez guardan relación con el tipo de trabajo policial según éste sea bajo órdenes o sin ellas. También identificamos relaciones entre dichas dimensiones y diferentes niveles de fuerza que se aplican. Esta investigación cobra importancia por su abordaje psicosocial que prioriza la comprensión de las dimensiones subjetivas de los agentes, evitando explicar la práctica policial únicamente como un mecanismo para el control del orden social y político.

  12. Chemical species of europium (III) in ionic force media 0.02M, 0.1M, and 0.7M NaClO{sub 4} at 298 K; Especies quimicas del europio (III) en medios de fuerza ionica 0.02M, 0.1M y 0.7M NaClO{sub 4} a 298 K

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez R, E.; Jimenez R, M.; Solache R, M. [Instituto Nacional de Investigaciones Nucleares, Departamento de Quimica, A.P. 18-1027, C.P. 11801 Mexico D.F. (Mexico)

    2000-07-01

    In order to know the effects of the controlled or accidental liberation of the europium in the environment, it is necessary to know its chemical behavior in found conditions in oceans, ground and surface water. The behavior of this element in these environments can be controlled mainly by the hydrolysis and its interaction with inorganic and organic ions. (Author)

  13. Determination of the hydrolysis constants of Europium (III), in ion strength media 4, 5 and 6 M NaClO{sub 4} at 303 K; Determinacion de las constantes de hidrolisis del Europio (III), en medios de fuerza ionica 4, 5 y 6 M de NaClO{sub 4} a 303 K

    Energy Technology Data Exchange (ETDEWEB)

    Alvarado B, A.; Jimenez R, M.; Solache R, M. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1999-07-01

    This work was made with the purpose to complete information about the hydrolysis constants of Europium (III) in high ion strength media. So it was determined at a ion forces media 4, 5 and 6 M of sodium perchlorate at 303 K. The method used was the potentiometric with the aid of the Super quad computer program. In high ion strength media, the measurements of p H do not correspond directly to negative logarithm of the concentration of hydrogen ions, by this it is necessary to calibrate the electrode in these conditions. The Europium was hydrolized at pC{sub H} values greater 6 in all cases. The potentiometric method used under the described experimental conditions is adequate to determine the hydrolysis constants of Europium (III). According to the results and diagrams of chemical species of Europium obtained we can conclude that the hydrolysis constants, differ by its distribution but not in its identity. (Author)

  14. Solubility of La, Pr, Eu, Er and Lu in a media of 1M ionic force of NaCl by 303 K; Solubilidad de La, Pr, Eu, Er y Lu en medio de fuerza ionica 1M de NaCl, a 303 K

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez G, J.J.; Solache R, M.J.; Jimenez R, M.; Rojas H, A. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2002-07-01

    The solubility and the solubility product of La, Pr, Eu, Er and Lu in media of 1M ionic force of NaCl by 303 K was determined, by means of a radiochemical method and the pLn{sup -}pCH diagrams in free conditions of CO{sub 2} were constructed. Moreover, the non saturation and the saturated zones and with them the pCH precipitation bound were determined. Finally a comparison among the obtained data in this work and those reported in the literature in several media was realized. (Author)

  15. Towards Horizontal Architecture for Autonomic M2M Service Networks

    Directory of Open Access Journals (Sweden)

    Juhani Latvakoski

    2014-05-01

    Full Text Available Today, increasing number of industrial application cases rely on the Machine to Machine (M2M services exposed from physical devices. Such M2M services enable interaction of physical world with the core processes of company information systems. However, there are grand challenges related to complexity and “vertical silos” limiting the M2M market scale and interoperability. It is here expected that horizontal approach for the system architecture is required for solving these challenges. Therefore, a set of architectural principles and key enablers for the horizontal architecture have been specified in this work. A selected set of key enablers called as autonomic M2M manager, M2M service capabilities, M2M messaging system, M2M gateways towards energy constrained M2M asset devices and creation of trust to enable end-to-end security for M2M applications have been developed. The developed key enablers have been evaluated separately in different scenarios dealing with smart metering, car sharing and electric bike experiments. The evaluation results shows that the provided architectural principles, and developed key enablers establish a solid ground for future research and seem to enable communication between objects and applications, which are not initially been designed to communicate together. The aim as the next step in this research is to create a combined experimental system to evaluate the system interoperability and performance in a more detailed manner.

  16. A Survey on M2M Service Networks

    Directory of Open Access Journals (Sweden)

    Juhani Latvakoski

    2014-11-01

    Full Text Available The number of industrial applications relying on the Machine to Machine (M2M services exposed from physical world has been increasing in recent years. Such M2M services enable communication of devices with the core processes of companies. However, there is a big challenge related to complexity and to application-specific M2M systems called “vertical silos”. This paper focuses on reviewing the technologies of M2M service networks and discussing approaches from the perspectives of M2M information and services, M2M communication and M2M security. Finally, a discussion on technologies and approaches potentially enabling future autonomic M2M service networks are provided. According to our conclusions, it is seen that clear definition of the architectural principles is needed to solve the “vertical silo” problem and then, proceeding towards enabling autonomic capabilities for solving complexity problem appears feasible. Several areas of future research have been identified, e.g., autonomic information based services, optimization of communications with limited capability devices, real-time messaging, creation of trust and end to end security, adaptability, reliability, performance, interoperability, and maintenance.

  17. Diagramas de energía, fuerza y materia = Diagrams of energy, force and matter

    Directory of Open Access Journals (Sweden)

    Josep Maria Montaner

    2013-10-01

    Full Text Available ResumenEn este ensayo se va a tratar sobre arquitectura a partir de la definición de forma como “estructura esencial e interna, como construcción del espacio y de la materia”. Para ello, podemos establecer, como punto de partida, que el proceso de la arquitectura va de la energía, las fuerzas y la materia hacia la forma. Por tanto, teorizar sobre la forma en arquitectura nos lleva a reflexionar sobre tres fenómenos previos a su configuración: la energía, las fuerzas y la materia. Para seguir estos procesos físicos es útil remitirse al pensamiento postestructuralista de Gilles Deleuze y Félix Guattari, especialmente a su texto Mil Mesetas. Capitalismo y esquizofrenia (1980 y a conceptos como “rizoma” y “agenciamiento” y, sobre todo, utilizar la herramienta interpretativa y creativa del “diagrama”.Palabras claveenergía, fuerza, materia, forma, Deleuze, GuattariAbstractThis essay will deal on architecture from the defi nition of form as "critical and internal structure  as construction of space and matter." For that, we can establish, as a starting point, that the process of architecture goes from energy, forces and matter to form. Thus, theorizing about form in architecture leads us to refl ect on three prior phenomena to its confi guration: energy, forces and matter. To follow these physical processes is useful to refer the poststructuralist thought´s Gilles Deleuze and Felix Guattari, especially his text A Thousand Plateaus. Capitalism and Schizophrenia (1980 and concepts such as "rhizome" and "assemblage" and, above all, to use the creative and interpretative tool of "diagramme".Key wordsenergy, force, matter, form, Deleuze, Guattari

  18. Dinámica de la fuerza de trabajo en Cuba 1846-1931 (II

    Directory of Open Access Journals (Sweden)

    Orestes Gárciga Gárciga

    2014-06-01

    Full Text Available En «Dinámica de la fuerza de trabajo en Cuba 1846-1931» se estudia el procesamiento de los datos estadísticos que, acerca de la actividad laboral de la población, presentaron los censos de 1846, 1862, 1899, 1907, 1919 y 1931. Debido a su extensión, la obra ha sido dividida en tres partes para ser publicada en Novedades en Población. El presente artículo examina la evolución de la fuerza de trabajo en Cuba de 1846 a 1931, a través de diversas clasificaciones internacionales empleadas en estos estudios, y da continuidad a «Dinámica de la fuerza de trabajo en Cuba 1846-1931 (I», incluido en el número anterior de la revista (Año 9, Número 17, 2013. Abstract In «Dynamic of the workforce in Cuba 1846-1931» is studied the processing of statistical data showed by the 1846, 1862, 1899, 1907, 1919 and 1931 censuses about labor activity of the population. Due to its extension, this work has been divided in three parts so it can be published in Novedades en Población (News on Population. The current paper reviews the evolution of the work force in Cuba from 1846 to 1931, taking to account diverse international classifications used in this studies. It is the continuation of «Dynamic of the workforce in Cuba 1846-1931 (I», included in the previous number of this magazine.

  19. Mercado laboral y capital social en un contexto de alta movilidad de fuerza de trabajo.

    OpenAIRE

    Romo Genoy, Edgardo

    2015-01-01

    Esta investigación tiene como objetivo principal dar cuenta del mercado laboral y el nivel de capital social en un contexto de alta movilidad de fuerza de trabajo. Para este propósito se toma el caso de estudio en el corregimiento de Chiles, municipio de Cumbal (Colombia) ubicado en la frontera colombo ecuatoriana. En primer lugar se aborda el tema de investigación definiendo el mercado desde la perspectiva de Karl Polanyi, según la cual “el mercado” no se explica únicamente en acontecimiento...

  20. Estudio prospectivo de la ciberdefensa en las Fuerzas Armadas del Ecuador

    OpenAIRE

    Castro Peralvo, Edwin Javier

    2015-01-01

    Las guerras en la actualidad toman otra dimensión, ya no se trata de las clásicas operaciones que se desarrollan en el campo de batalla con las tradicionales armas de las Fuerzas Armadas y sus soldados enfrentándose por ocupar un territorio, actualmente se desarrolla otro tipo de guerra en otro escenario que es el ciberespacio. Existen ejemplos reales que se han desarrollado ciberguerras entre algunos países como el de Rusia y Estonia en el año 2007, Estonia fue atacada su infraestructura crí...

  1. La comunicación en las fuerzas de seguridad del Estado

    Directory of Open Access Journals (Sweden)

    María de las Mercedes Cancelo San Martín

    2014-12-01

    Full Text Available La búsqueda de legitimización social de las instituciones es una de las claves de la comunicación institucional. Independiente de su actividad organizacional la comunicación debe ser la nueva interpretación del concepto de responsabilidad social. Existe un deber: el de comunicar, pues en cualquier sociedad democrática toda actividad organizacional empieza con el consentimiento del público y éste debe saber si las fuerzas de seguridad cumplen las funciones para las que fueron creadas. Presenta algunos estudios de caso.

  2. Insuficiencia normativa sobre roles y funciones para los miembros de la Fuerza Pública

    OpenAIRE

    Morales Hernández, Martha Lizett; Ruiz, Jesus A.

    2016-01-01

    Atendiendo al interés de conocer la manera en que se han manejado en Colombia las políticas sobre Seguridad y Defensa Nacional, respecto de la seguridad jurídica de los miembros de la Fuerza Pública, el presente artículo bajo el método bibliográfico e histórico, plantea en su primera parte, la manera en que los gobiernos elegidos a partir de la Constitución de 1991, concibieron la Seguridad y la Defensa, así como sus políticas sobre este particular; posteriormente, se estudian las normas sobr...

  3. VISUALIZACIÓN DE LA MITOSIS CON EL MICROSCOPIO DE FUERZA ATÓMICA

    Directory of Open Access Journals (Sweden)

    María de Lourdes Segura-Valdez

    2008-01-01

    Full Text Available En eucariontes, la división celular generalmente ocurre por medio de la mitosis. En estudios previos hemos documentado la posibilidad de estudiar la estructura celular in situ con el microscopio de fuerza atómica, con énfasis en la estructura nuclear en interfase. En este trabajo mostramos que las diferentes etapas de la mitosis pueden ser visualizadas con este instrumento, lo que abre la posibilidad de estudiar este fenómeno en el rango nanométrico.

  4. Aproximación al diseño de un cuantificador de entrenamiento de fuerza

    OpenAIRE

    Torres Fernández, Francisco

    2014-01-01

    En el ámbito de la actividad física, cada vez es más común el uso de gadgets para cuantificar el entrenamiento que realizamos. De esta manera, el usuario dispone de datos de distancia, velocidad, calorías quemadas… lo que le supone un mayor conocimiento sobre la calidad del entrenamiento que ha realizado. Pero si nos fijamos en el mercado de este tipo de gadgets solo miden entrenamiento cardiovascular sin haber aún ninguno que cuantifique un entrenamiento de fuerza, el cual sería de gran util...

  5. Des-Lys58-beta 2m and native beta 2m in rheumatoid arthritis serum and synovial fluid

    DEFF Research Database (Denmark)

    Williams, R C; Malone, C C; Nissen, Mogens Holst

    1995-01-01

    -Lys58-beta 2m were found in 80% of 21 SF from RA patients and in 43% of 41 SF from other subjects with various forms of inflammatory arthritis. In RA and other disorders such as gout or pseudogout, levels of Des-Lys58-beta 2m were higher in synovial fluid than in serum during an acute episode...

  6. La Infantería de Marina, una fuerza para el siglo XXI

    Directory of Open Access Journals (Sweden)

    González Muñoz, Francisco

    2002-10-01

    Full Text Available Not available

    Nuestra Infantería de Marina es la más antigua del mundo. Sus orígenes se remontan al Tercio de Ñapóles de 1537, y desde entonces sus fuerzas han mantenido su tradición naval y expedicionaria con una permanente vinculación a la Armada. Tras una referencia histórica a las diferentes campañas en que ha participado la Infantería de Marina, el que fue su Comandante General durante los últimos cuatro años nos introduce en las vicisitudes y proceso de evolución de este Cuerpo como componente esencial de la Fuerza Anfibia de la Flota, destacando su versatilidad y capacidad de respuesta a las exigencias de hoy día para actuar como vanguardia de la proyección del poder naval en los nuevos escenarios estratégicos que se nos presentan. El artículo es una excelente síntesis para quien desee conocer qué.esy cómo opera la Infantería de Marina, cuáles son sus capacidades, medios, organización y estructura, y cómo está adaptándose para afrontar los desafíos del futuro a medio plazo.

  7. Fuerzas Armadas y transición democrática. Argentina, 1983-1989

    Directory of Open Access Journals (Sweden)

    Andrés Alberto Masi Rius

    2009-12-01

    Full Text Available El presente trabajo procura analizar el grado de influencia que las instituciones militares tuvieron en la apertura democrática argentina en 1983. Se analizará la modalidad en que las Fuerzas Armadas influyeron en los discursos en la campaña electoral, las medidas implementadas por la Administración Alfonsín en materia militar, los desequilibrios internos del Ejército Argentino, la disposición (o no de las Fuerzas de subordinarse al poder civil y el rol que las mismas desempeñaron en los levantamientos de 1987 y 1989, líneas que permitirán una adecuado análisis de los aciertos y fragilidades de las estrategias de gobierno en la esfera castrense.______________________ABSTRACT:The research has the purpose of analyzing the influence of the Army institutions during the return to the argentinian democratic system in 1983. It tries to study the way in which the Army influenced in the speeches of the electoral campaign, the political decisions put in practice by the Alfonsin Administration in military order, the Argentinian Forces imbalances, the disposition (or not of subordinating to the civil power and their role during the mutinies between 1987 and 1989, ideas that will allow an adequate analysis of the abilities and fragilities of the government strategies in the military sphere.

  8. LAS FUERZAS ARMADAS EN ESPAÑA: ¿ÚLTIMO BASTIÓN DEL FRANQUISMO?

    Directory of Open Access Journals (Sweden)

    Rafael C. Martínez Martínez

    2011-01-01

    Full Text Available Las complicadas relaciones civiles-militares en España tienen como elemento subyacente los duros años de dictadura franquista. En esa tesitura, preguntarse si las fuerzas armadas españolas han culminado su consolidación democrática y han dejado de ser poder político, para convertirse en administración militar resulta pertinente. El presente trabajo sustentado mediante datos de opinión pública y datos extraídos de diversos entrevistas y cuestionarios realizados a los futuros mandos de las fuerzas armadas españolas, devela qué progresos, intensos, se han realizado en ese sentido y qué déficits quedan todavía por solventar, concluyendo en el innegable talante democrático y asunción de la supremacía civil por parte de la oficialidad y suboficialidad más joven del ejército (Tierra, Armada y Aire Español.

  9. ENVEJECIMIENTO, MASA MUSCULAR Y ENTRENAMIENTO DE LA FUERZA: UNA REVISIÓN

    Directory of Open Access Journals (Sweden)

    Santiago Adolfo Arboleda Franco

    2014-11-01

    Full Text Available En este artículo se revisan los fundamentos sobre los cuales se ha reconocido la fuerza como elemento esencial en las prescripciones de ejercicio físico para la salud, específicamente en las personas mayores. Se describen las implicaciones de la sarcopenia como síndrome propio de este periodo vital y los hallazgos sobre la importancia de la masa muscular en el equilibrio homeostático mediante su función endocrina. También se examina lo propuesto desde consensos y declaraciones de asociaciones científicas sobre el entrenamiento de distintas manifestaciones de la fuerza en un contexto de salud y se revisa lo hallado en algunos meta–análisis y revisiones sistemáticas recientes sobre los efectos de este entrenamiento en distintas variables relacionadas con la capacidad funcional. Por último, se señalan algunos horizontes de investigación en el tema.

  10. MEDICION IN VITRO DE LA FUERZA DE FRICCIÓN EN DUPLAS ARCO-BRACKET CON ANGULACIÓN

    OpenAIRE

    Murillo Mora, Emmanuel

    2012-01-01

    En ortodoncia se utilizan técnicas que buscan un máximo control sobre el movimiento de los dientes. Uno de los múltiples factores a considerar en la selección del material, es optar uno que genere menor fuerza friccional.(23). La reducción de la fricción es una de las metas para la nueva generación de bracket. Se investigó la fuerza friccional de 3 tipos de bracket de diferentes marcas comerciales siendo uno de autoligado (Smart Clip) y los otros con eslastomero, en este cas...

  11. Respuesta Sísmica de un puente en Arco considerando la Fluctuación de la fuerza Axial

    OpenAIRE

    Chávez Aguirre, Hidalgo

    2011-01-01

    Los puentes en arco son estructuras que exhiben un comportamiento muy constante, ya que por un lado trabajan de una manera muy eficiente ante cargas permanentes y por el otro presentan un desempeño complejo ante la ocurrencia de temblores fuertes. El arco es un elemento con ductibilidad limitada debido a las elevadas fuerzas de compresión generadas por la carga permanente; además, dichas fuerzas pueden variar de manera importante durante la ocurrencia de un movimiento sísmico. Por lo anterio...

  12. Análisis de las Fuerzas Absolutas y las Circunferencias de Volumen Durante el Período Preparatorio.

    Directory of Open Access Journals (Sweden)

    Francisco Freyre Vázquez

    2003-01-01

    Full Text Available Se aborda la relación de dependencia entre los resultados de las fuerzas absolutas de los planos musculares brazo, tronco y pierna, en correspondencia con las circunferencias máximas de volumen de los miembros superiores e inferiores durante la preparación de fuerza a que fueron sometidos los atletas de baloncesto de la categoría juvenil durante el periodo preparatorio. De esta forma estaríamos hablando de la estrecha relación que existe en cuanto a esta variable, repercutiendo en los resultados a alcanzar por el equipo durante el proceso de entrenamiento.

  13. A distributed approach for secure M2M communications

    OpenAIRE

    BEN SAIED , Yosra; OLIVEREAU , Alexis; LAURENT , Maryline

    2012-01-01

    International audience; A key establishment solution for heterogeneous Machine to Machine (M2M) communications is proposed. Decentralization in M2M environment leads to situations where highly resource-constrained nodes have to establish end-to-end secured contexts with powerful remote servers, which would normally be impossible because of the technological gap between these classes of devices. This paper proposes a novel collaborative session key exchange method, wherein a highly resource-co...

  14. Development of 4-shot pellet injector for JET-2M

    International Nuclear Information System (INIS)

    Noda, O.; Kuribayashi, S.; Uchikawa, T.; Onozuka, M.; Kasaki, S.; Hasegawa, K.

    1987-01-01

    A pneumatic 4 pellet injector has been constructed for JFT-2M. The performance tests have proved high performance and reliability of the injector. The maximum pellet velocity obtained in hydrogen pellet tests is 1.4km sec. The device is now in use for JFT-2M in a place of a previous single pellet injector, contributing to plasma studies. In this paper the outline of features and performance of the device is presented

  15. Aportaciones sobre la eficacia del método Pilates en la fuerza, el equilibrio y el riesgo de caídas de personas mayores

    Directory of Open Access Journals (Sweden)

    D. Reche-Orenes

    2016-06-01

    Conclusiones: El método Pilates es eficaz para mejorar la fuerza isométrica de cadera y el equilibrio en personas mayores, reduciendo el riesgo de caídas. No existen evidencias suficientes para determinar si la fuerza del core tiene que ver con el equilibrio y las caídas.

  16. Pascua Militar: las órdenes del Rey a las Fuerzas Armadas

    Directory of Open Access Journals (Sweden)

    Miguel Ballenilla y García de Gamarra

    2015-06-01

    Full Text Available La Pascua Militar constituye un so-lemne acto castrense presidido por S.M. el Rey al que asisten la Familia Real y las primeras autoridades del Estado. Por su carácter marca-damente institucional, el discurso del Rey es el más relevante de los que se dirigen a las Fuer-zas Armadas. En este trabajo se analiza la evo-lución del citado discurso en las últimas cuatro décadas, los elementos que centran su conteni-do, su relación con el papel que ejerce el Rey como Jefe Supremo de las Fuerzas Armadas, y los acontecimientos que afectan a los Ejércitos y la Defensa Nacional.Palabras clave: Discurso, Análisis, Pascua Mili-tar, Rey, Fuerzas Armadas, Constitución, Transi-ción, Terrorismo._______________ 800x600 Normal 0 21 false false false ES X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} The “Pascua Militar” is a solemn mili-tary ceremony presided by HM The King at-tended by the Royal Family and the highest authorities of the state. The importance of this institutional event becomes the King’s speech as the most relevant of which are addressed to the Armed Forces. In this paper we analyse the evolution of that discourse in the last four dec-ades, we identify the elements that focus their content, it relationship to the role played by the King as Supreme Commander of the Armed Forces and the events affecting them and Na-tional Defence.Keywords: Speech, Analysis, King, Armed Forc-es, Constitution, Political change, Terrorism. Normal 0 21 false false false ES X-NONE X-NONE MicrosoftInternetExplorer4

  17. Radioimmunoassay of Alb, β2-M and THP

    International Nuclear Information System (INIS)

    Xie Zhiyuan; Li Shengqi; Ren Shusheng; Chen Yuying

    1993-01-01

    The combined determination of β 2 -M, THP, Alb, IgG may be used as the sensitive indication of the early degeneration of kidney function. The authors observed 107 cases, and found that the anomalous examine-out ratios of hemorrhage β 2 -M and UTHP are 50.75% and 65.67% respectively, 1.5-2.3 times higher than the C cr animals examine-out ratio. The radio-immunoassay of β 2 -M and THP is a better measure for discovering light kidney function injury in early period than C cr method. The clinical value of the radio-immunoassay of β 2 -M, THP is obviously better than the traditional and classical method. The diseases of anybody system may influence the kidney function through various mechanisms. The retrogression of kidney tissue of the patients in old-and mid-age leads to decrease of kidney function. The combination of β 2 -M and THP has the highest anomalous examine-out ratios of kidney function; the next is urine Alb

  18. Multi-channel bolometer system on JFT-2M tokamak

    International Nuclear Information System (INIS)

    Tamai, Hiroshi; Maeno, Masaki; Matsuda, Toshiaki; Matoba, Tohru

    1988-07-01

    Multi-channel bolometer system is designed and installed to observe the radiation profile on JFT-2M tokamak. Sensor head is made of Thinistor, which is a kind of semiconductor, because it has the advantage of higher sensitivity of about one order of magnitude than the conventional metal foil bolometer and is suitable for the profile measurement in which the signal from the plasma is relatively small. The response and cooling characteristics of the bolometer sensor are suitable for the condition of JFT-2M tokamak plasma. Low noise circuit of bridge and differentiator is developed to optimize the signal to noise ratio in the JFT-2M operating condition. With use of the bolometer system, the radiation profile in joule heating plasma as well as additional heating plasma especially in H-mode plasma is successfully observed. (author)

  19. Programa de instrucción y entrenamiento búsqueda y rescate para la Fuerza Aérea Colombiana

    OpenAIRE

    Javier Eduardo Losada Sierra; Edgar Sánchez Canosa; José Antonio Polo Quesada

    2006-01-01

    Esta investigación tuvo como finalidad elaborar un programa de instrucción y entrenamiento para misiones de búsqueda y rescate, teniendo en cuenta que la Fuerza Aérea Colombiana cumple diariamente operaciones aéreas en todo el territorio nacional que implican riesgos para las tripulaciones y pasajeros de las aeronaves.

  20. Improved confinement during ICRF heating on JFT-2M

    International Nuclear Information System (INIS)

    Matsumoto, Hiroshi; Ogawa, Toshihide; Tamai, Hiroshi

    1986-10-01

    Significant improvement of energy confinement was observed on JFT-2M during ICRF heating. This improvement is associated with the sudden depression of H α /D α emission and the following increase of plasma stored energy, electron density and the radiation loss. This should be the same phenomena as H-mode transitions observed in ASDEX, PDX, and D-III divertor experiments with neutral beam injection heating. However, this transition is also observed in limiter discharges as well as in open divertor configurations on JFT-2M. (author)

  1. Globalizacion, seguridad y crisis. El papel de las fuerzas armadas en el siglo XXI

    Directory of Open Access Journals (Sweden)

    Federico Aznar Fernández-Montesinos

    2015-06-01

    Full Text Available El siglo XXI es el siglo de la interconexión y la complejidad. Todo se encuentra interrelacionado, lo que ha obligado a incluir la Defensa en el marco de la Seguridad con el propósito de dar respuestas a los retos que plantea y que ya no son solo militares sino de toda índole, incluidas crisis y catástrofes. Las fuerzas Armadas pueden contribuir con gran eficacia a la hora de atender tales retos. La tendencia no es ya al conflicto entre naciones, sino a la defensa de la Seguridad Nacional e Internacional, lo que genera un enorme cambio en los medios, preparación y doctrina.

  2. Agenda de derechos en Uruguay. Acontecimiento, biopolítica, inmunidad y fuerza de ley

    Directory of Open Access Journals (Sweden)

    Sebastián Aguiar Antía

    2018-03-01

    Full Text Available La aprobación entre 2013 y 2014 y la posterior implementación en Uruguay de un conjunto de iniciativas novedosas (regulación de la marihuana, legalización del aborto, matrimonio igualitario y otras presenta varias aristas interesantes desde una perspectiva "biopolítica": la procedencia de estos cambios legislativos, finalmente "acontecimental", una ola de protestas; el carácter crucial y ambivalente de las relaciones de edad detrás de esta nueva agenda; la entrada en la escena de la gubernamentalidad y la regulación de la vida; los procedimientos de inmunización que mantienen nuevos límites tras la incorporación. Finalmente, se muestra la existencia de un cierto estado de excepción, donde fuerzas diferenciales disputan el ejercicio de la ley tras su aprobación legislativa.

  3. Posición de garante de los miembros de la Fuerza Pública

    Directory of Open Access Journals (Sweden)

    Jaime Vargas García

    2006-01-01

    Full Text Available En los medios de comunicación de Colombia aparecen continuas informaciones relacionadas con la ocurrencia de hechos de violencia en nuestro país que principalmente afectan a la población civil por la acción de grupos al margen de la ley, por los cuales se viene atribuyendo responsabilidad al Estado y consecuencias penales y disciplinarias por comisión por omisión contra miembros de la Fuerza Pública. Todo parte de “la posición de garante” de las Fuerzas Militares en relación con la defensa nacional y de la Policía sobre la seguridad nacional que obliga a todos sus miembros a proteger la vida y los demás derechos fundamentales relacionados con este de todos los residentes en Colombia. Precisamente el artículo 25 de la Ley 522 de 1999 se encarga de regular la posición de garante en Colombia y el tema adquiere mayor importancia cuando se trata de juzgar conductas de miembros de la Fuerza Pública debido a que la imputación de la omisión se origina precisamente en la delimitación de los ámbitos de competencia de estas instituciones. Sin embargo, la experiencia del conflicto armado nos indica que no existen fronteras perfectamente delimitadas entre las funciones de defensa y seguridad nacional y en el caso de la misma omisión impropia y la posición de garante hay posiciones doctrinales divergentes que no ofrecen ninguna seguridad al asunto y que dificultan la aplicación de esta figura tal como lo reseñamos a lo largo del trabajo y como los destacan importantes autores nacionales y extranjeros. Todo lo anterior viene afectando el desarrollo de las causas penales y a ello se suman las deficiencias del sistema judicial de Colombia particularmente el cuestionamiento nacional e internacional de la jurisdicción penal militar y las sanciones adoptadas por la Corte Interamericana de Derechos Humanos contra el Estado Colombiano. Así mismo, el “concepto de relación con el servicio” del artículo 221 de la carta Política nos parece

  4. RELACIÓN ENTRE DIFERENTES PRUEBAS DE CAMPO: FUERZA, POTENCIA Y VELOCIDAD

    Directory of Open Access Journals (Sweden)

    Jessenia Hernández Elizondo

    2003-12-01

    Full Text Available Esta investigación tuvo como propósito principal el encontrar por medio de pruebas en las variables de fuerza, potencia y velocidad, la relación matemática existente entre estos tres constructos. Participaron 56 sujetos varones con edades entre 18 y 25 años. Con el fin de responder al objetivo del estudio, se les aplicaron pruebas de campo de fuerza (1RM de sentadilla completa y repeticiones máximas al 80% 60% 40% y 20%, de velocidad (30 metros lanzados y 30 metros sin impulso, y de potencia (salto vertical con contra-movimiento SVCM, salto vertical sin impulso SVSI y salto vertical con caída SVCC, para correlacionar las diferentes pruebas entre sí. Los datos fueron analizados por medio de la correlación de Pearson (r, para correlacionar parejas de pruebas y correlación canónica (Rc para correlacionar grupos de variables. A partir de cada correlación se obtuvo la varianza explicada (r2 la cual indica el porcentaje de relación compartida en escala de 0-100 que existe entre las pruebas. Según los datos obtenidos, no existe relación significativa (2.1% entre las pruebas de salto-sentadilla, ni relación significativa (5.1% entre las pruebas de velocidad- sentadilla, mientras que la relación salto- velocidad (62%, fue estadísticamente significativa (p < 0.05. La implicación de estos resultados podrían respaldar la idea de que la relación teórica que existe entre estos constructos, no es completamente cierta cuando éstos son medidos por medio de pruebas de campo.

  5. Las fuerzas armadas en América Latina, antes y hoy

    Directory of Open Access Journals (Sweden)

    Dirk Kruijt

    2012-07-01

    Full Text Available Se esboza en la primera parte del presente artículo el legado político de las fuerzas armadas: intromisión en el sistema político, golpes y dictaduras militares, pero también el hecho de que exmilitares son generalmente exitosos en elecciones democráticas. En un segundo momento se analiza tanto la ideología como las características de los “ejércitos políticos” en las décadas pasadas: el monopolio sobre el “patriotismo nacional”, traducido en doctrinas de seguridad nacional y el dominio sobre la inteligencia nacional y las fuerzas de la policía, la ejecución de programas cívico-militares de desarrollo local en zonas remotas y la inmunidad de facto con cierta base legal. Luego se presenta una tipología durante la transición hacia la democracia: tutelaje militar, control manso e impunidad. El análisis sigue con el desarrollo de otra tipología de militares y soldados en el poder bajo el régimen democrático electoral: caudillos militares transformados en demócratas y exguerrilleros como presidentes elegidos. Es seguido por dos formas recientes de sucesión presidencial por mecanismos no electorales: la expulsión de presidentes por revueltas populares y algunos (intentos de golpes. Luego se presenta un análisis de nuevas agendas de seguridad y nuevas misiones militares durante la primera década del presente siglo. Se enfatiza explícitamente la actuación militar en el contexto de la lucha (“guerra” contra el crimen organizado, la guerra contra la droga y los efectos sobre la seguridad interna.

  6. Evaluación de la fuerza explosiva de extensión de las extremidades inferiores en escolares

    Directory of Open Access Journals (Sweden)

    Francisco José López Gallego

    2016-01-01

    Full Text Available Objetivo. El objetivo de esta investigación es evaluar la capacidad de fuerza explosiva de extensión de extremidades inferiores en escolares de educación primaria y analizar las diferencias que puedan existir tanto en capacidad de fuerza explosiva de extremidades inferiores como en composición corporal en función del sexo. Material y métodos. En este estudio han participado 90 estudiantes (54 niños y 36 niñas de educación primaria de un centro educativo urbano de la provincia de Jaén. La media de la edad de los sujetos es de 11,1 ± 0,7 años. Se ha realizado la valoración de la composición corporal y la evaluación de la capacidad de fuerza explosiva de extremidades inferiores mediante salto vertical. La evaluación de la composición corporal se llevó a cabo mediante la plataforma INBODY 230 (Microkaya, Spain. Para medir las variables de los saltos se utiliz ó una plataforma de fuerzas Quattro Jump (Kistler, Suiza y se realizaron los test de salto CMJ y ABK. Resultados y conclusiones. Los resultados obtenidos en las variables de los test de salto por los participantes se encuentran entre los valores de referencia para sujetos de su edad. Las chicas poseen mayores picos de potencia y de fuerza que los chicos, mientras que estos poseen mayores alturas de vuelo en los saltos. En la impedancia los chicos obtienen mayores porcentajes de músculo y las chicas mayor masa y mayores porcentajes de grasa.

  7. Electronographic calibration of UK 1.2-m Schmidt plates

    International Nuclear Information System (INIS)

    Hawkins, M.R.S.

    1979-01-01

    Two electronographic sequences are given in the South Galactic Pole region down to msub(B) = approximately 23 +- 0.3 mag. These sequences are used to obtain a calibration for COSMOS measures of UK 1.2-m Schmidt plates and evaluate their photometric transfer properties. (author)

  8. Figure output program for JFT-2M experimental data

    International Nuclear Information System (INIS)

    Miura, Yukitoshi; Mori, Masahiro; Matsuda, Toshiaki; Takada, Susumu.

    1991-11-01

    The software for the figure output of JFT-2M experimental data is reported. Since the configuration of a figure is determined by some easy input parameters, then any format of each experimental output is configured freely by this software. (author)

  9. TV thomson scattering system on JFT-2M

    International Nuclear Information System (INIS)

    Yamauchi, Toshihiko; Shiina, Tomio; Ishige, Yoichi; Dimock, D.

    1995-01-01

    A higher spatial resolution TV Thomson scattering system was constructed on JFT-2M tokamak. This system has been providing complete profiles of Te and ne at a single time during a plasma discharge. New detector system was developed composed of two stages of image intensifier tubes coupled to a CCD. The extinction ratio of image intensifier was improved to 1.4 x 10 7 at least. (author)

  10. Fuerza pública, negociaciones de paz y posacuerdo en Colombia, de E. Cruz Rodríguez

    Directory of Open Access Journals (Sweden)

    Roland Marcelo Franco Grisales

    2017-01-01

    Full Text Available En este texto, el politólogo de la Universidad Nacional de Colombia y magíster en Análisis de Problemas Políticos, Económicos e Internacionales Contemporáneos, Edwin Cruz Rodríguez, presenta una reflexión inicial acerca de la función de la fuerza pública colombiana (FP —compuesta por los cuerpos de Ejército y Policía Nacional— en un posible escenario de posacuerdo, de cara a los diálogos de paz que se desarrollaron en La Habana, Cuba, entre el Gobierno nacional de Colombia y las Fuerzas Armadas Revolucionarias de Colombia (FARC-EP.

  11. Ejercicios de fuerza, glucocorticoides y composición corporal en pacientes diabéticos de la tercera edad

    Directory of Open Access Journals (Sweden)

    Yolanda Cedeño Almaguer

    2010-01-01

    Full Text Available Se presentaron los resultados obtenidos a través de un cuasi- experimento que reveló los efectos del entrenamiento de fuerza sobre la composición corporal de pacientes diabéticos de la tercera edad, sometidos a tratamientos con glucocorticoides. La muestra estuvo constituida por 13 pacientes (8 mujeres y 5 hombres los cuales comenzaron, por prescripción médica, tratamiento con glucocorticoides. Por medio de mediciones antropométricas se determinaron indicadores de adiposidad y masa muscular en tres ocasiones, entre las que se incluye la etapa después de aplicado un programa de entrenamiento de 12 semanas sobre la base de ejercicios de fuerza.

  12. Conceptual design of HL-2M tokamak control system

    International Nuclear Information System (INIS)

    Xia Fan; Chen Liaoyuan; Song Xianming; Zhang Jinhua; Lou Cuiwen; Pan Yudong

    2009-01-01

    The static architecture, dynamic behavior, control theory and simulation of HL-2M tokamak control system are described. The real-time network will be build for the communication of real-time control among its subsystems and universal timing system will be build to guarantee the synchronization among the subsystems. The duty to achieve preprogrammed parameters is carried out by plasma discharge control. In order to reduce the damage made by discharge exception, the error-handing mechanism of supervision system is considered. The controllers of magnetic control system are designed to control the current, shape and position of plasma and simulation system is designed for testing the controllers. (authors)

  13. Development and use of the IVV-2M fuel assembly

    International Nuclear Information System (INIS)

    Aden, V.G.; Bulkin, Yu.M.; Vasenkov, V.I.

    1987-01-01

    The design and performance of a fuel assembly, intended for use in the water cooled and moderated IVV-2M research reactor and consisting of dioxide dispersed in an aluminium alloy matrix encased in an aluminium alloy can, is presented. Experimental and theoretical studies included neutron characteristics of the reactor core, thermohydraulic behavior, and thermal neutron flux distribution. Data are also presented on the specific charge in u 235, the metal to water volume ratio, the specific heat removal surface, and maximum power of the assembly

  14. Programa de evaluación continua de riesgos para la aeronavegabilidad en la Fuerza Aérea Colombiana (CARE

    Directory of Open Access Journals (Sweden)

    Ana Isabel Aguilar González

    2010-01-01

    Igualmente, busca proponer la implementación de acciones efectivas que mitiguen su influencia negativa, mediante la optimización de los procesos de gestión organizacional empleados en el mantenimiento aeronáutico, esperando que se constituya en un aporte valioso para poder conocer la condición actual de la aeronavegabilidad y sus efectos en la seguridad operacional dentro de la Fuerza Aérea Colombiana.

  15. La fuerza vinculante de la jurisprudencia en el orden jurídico colombiano

    Directory of Open Access Journals (Sweden)

    Carlos Bernal Pulido

    2003-12-01

    Full Text Available El carácter de la fuente formal y material del derecho que hoy tiene la jurisprudencia no es una innovación de la Constitución Política de 1991. El artículo propone una definición operativa de fuerza vinculante, muestra cómo los elementos de esa definición se verifican en la jurisprudencia y cuál es el sentido constitucionalmente adecuado que se ha de otorgar entonces a la expresión “criterio auxiliar” en el artículo 230 de la Constitución. La argumentación hace ver por qué el trabajo de aplicación judicial del derecho lleva consigo la creación judicial de normas jurídicas contenidas en la parte motiva de las sentencias. Tales normas, que deberían llamarse adscritas, resultan vinculantes para las altas cortes de manera sui generis. Es necesario diseñar un procedimiento de control de la sujeción de los jueces ordinarios a la jurisprudencia constitucional, que también formule de manera explícita las reglas a las que haya de atenerse la Corte Constitucional.

  16. Terminología de los ejercicios de fuerza con sobrecargas (I

    Directory of Open Access Journals (Sweden)

    Francesc Cos Morera

    2016-01-01

    Full Text Available Las ciencias aplicadas a la actividad física y el deporte son relativamente recientes y deben de estandarizar todavía su vocabulario en algunas áreas de conocimiento. Establecer una terminología de consenso y unívoca en relación a los ejercicios de fuerza es fundamental para los profesionales que trabajan en las ciencias del ejercicio físico y el cuerpo humano. Es imprescindible articular una terminología unívoca en este sector de intervención social de gran repercusión. El derecho a la libre circulación de personas por los países de la Unión Europea y, en general, la globalización, hace necesario también el conocimiento de la terminología de la musculación en otras lenguas vehiculares. El siguiente artículo es el primero de una serie de cuatro y presenta los ejercicios más representativos de pecho y hombro en versiones castellana, catalana e inglesa, con el objetivo que conformen una base de gran alcance que permita definir otros ejercicios.

  17. Terminología de los ejercicios de fuerza con sobrecargas (y IV

    Directory of Open Access Journals (Sweden)

    Francesc Cos Morera

    2011-12-01

    Full Text Available Las ciencias aplicadas a la actividad física y el deporte son relativamente recientes y deben estandarizar todavía su vocabulario en algunas áreas de conocimiento. Establecer una terminología de consenso y unívoca en relación con los ejercicios de fuerza con sobrecargas es fundamental para los profesionales que trabajan en las ciencias del ejercicio físico y el cuerpo humano. Es imprescindible articular una terminología vehicular en este sector de intervención social de gran repercusión. El derecho a la libre circulación de personas por los países de la Unión Europea y, en general, la globalización, hace necesario también el conocimiento de la terminología de la musculación en otras lenguas vehiculares. El siguiente artículo es el último de una serie de cuatro y presenta los ejercicios más representativos de extremidad inferior como, abductores, aductores, extensores y flexores de la cadera, extensores y flexores de la rodilla, flexores del pie y levantamientos olímpicos, en versiones castellana, catalana e inglesa, con el objetivo de que conformen una base de gran alcance que permita definir otros ejercicios

  18. Terminología de los ejercicios de fuerza con sobrecargas (III

    Directory of Open Access Journals (Sweden)

    Francesc Cos Morera

    2009-11-01

    Full Text Available Las ciencias aplicadas a la actividad física y el deporte son relativamente recientes y deben estandarizar todavía su vocabulario en algunas áreas de conocimiento. Establecer una terminología de consenso y unívoca en relación con los ejercicios de fuerza es fundamental para los profesionales que trabajan en las ciencias del ejercicio físico y el cuerpo humano. Es imprescindible articular una terminología vehicular en este sector de intervención social de gran repercusión. El derecho a la libre circulación de personas por los países de la Unión Europea y, en general, la globalización, hace necesario también el conocimiento de la terminología de la musculación en otras lenguas vehiculares. El siguiente artículo es el tercero de una serie de cuatro y presenta los ejercicios más representativos de espalda, abdominales y estabilizadores, en versiones castellana, catalana e inglesa, con el objetivo de que conformen una base de gran alcance que permita definir otros ejercicios.

  19. Terminología de los ejercicios de fuerza con sobrecargas (II

    Directory of Open Access Journals (Sweden)

    Francesc Cos Morera

    2011-06-01

    Full Text Available Las ciencias aplicadas a la actividad física y el deporte son relativamente recientes y deben estandarizar todavía su vocabulario en algunas áreas de conocimiento. Establecer una terminología de consenso y unívoca en relación con los ejercicios de fuerza es fundamental para los profesionales que trabajan en las ciencias del ejercicio físico y el cuerpo humano. Es imprescindible articular una terminología unívoca en este sector de intervención social de gran repercusión. El derecho a la libre circulación de personas por los países de la Unión Europea y, en general, la globalización, hace necesario también el conocimiento de la terminología de la musculación en otras lenguas vehiculares. El siguiente artículo es el segundo de una serie de cuatro y presenta los ejercicios más representativos de rotadores internos y externos del hombro, elevadores del hombro, flexores del codo, extensores del codo y flexores y extensores de la muñeca en versiones castellana, catalana e inglesa, con el objetivo de que conformen una base de gran alcance que permita definir otros ejercicios.

  20. Aplicación de un sistema para calcular déficit de fuerza resistencia en atletas de fondo

    Directory of Open Access Journals (Sweden)

    Eduardo Valcarce Merayo

    2012-12-01

    Full Text Available Con este estudio se pretende determinar la evolución en la longitud de zancada en atletas de resistencia que no periodizan el entrenamiento de fuerza. En el estudio participaron 6 sujetos varones atletas de resistencia de 31 años (± 4,6 años, con una experiencia deportiva de 14 años (± 4 años que realizaron un entrenamiento interválico donde se determinó la velocidad, frecuencia y amplitud de zancada media de cada repetición a partir de la zona de grabación. El porcentaje de pérdida de amplitud de zancada, medido a través del índice SLS (stride loss strength comparó dicha pérdida de longitud de zancada (cm/m ∙ s–1 entre grupos de repeticiones: Grupo 1 (repeticiones 1-7, Grupo 2 (repeticiones 8-14, Grupo 3 (repeticiones 15-21 observándose un descenso significativo en el índice SLS entre Grupo 2 y el Grupo 3 (p = 0,05. Concluyendo que este indicador es una herramienta específica para determinar posibles déficits de fuerza en este tipo de deportistas, ayudando a entrenadores y atletas que quieran evaluar los niveles de fuerza resistencia en una medición de campo.

  1. Compact toroid injection system for JFT-2M

    Energy Technology Data Exchange (ETDEWEB)

    Fukumoto, N. [University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280 (Japan)]. E-mail: fukumotn@eng.u-hyogo.ac.jp; Ogawa, H. [Japan Atomic Energy Agency (JAEA), 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan); Nagata, M. [University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280 (Japan); Uyama, T. [University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280 (Japan); Shibata, T. [Japan Atomic Energy Agency (JAEA), 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan); Kashiwa, Y. [Japan Atomic Energy Agency (JAEA), 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan); Suzuki, S. [Japan Atomic Energy Agency (JAEA), 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan); Kusama, Y. [Japan Atomic Energy Agency (JAEA), 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan)

    2006-11-15

    The compact toroid (CT) injection system for JFT-2M is composed of a CT injector, a gas delivery and vacuum system, a power supply system, and a diagnostics system. In particular, the power supply system delivers high performance for CT formation and acceleration. The CT formation capacitor bank unit achieved a formation current of 350 kA with a rise time less than 10 {mu}s. Although the CT acceleration bank units are equipped with 14 ignitron switches instead of gap switches to attenuate the discharge noise level, an acceleration current of 400 kA with a short rise time of 9 {mu}s is controlled within a jitter of much less than 1 {mu}s. The resulting CT velocity and mass density satisfy the requirements for CT penetration into the tokamak plasma core at a toroidal field of 1 T. This CT injection system is thus suitable for CT injection in a middle-sized tokamak plasma such as the JFT-2M tokamak.

  2. Compact toroid injection system for JFT-2M

    International Nuclear Information System (INIS)

    Fukumoto, N.; Ogawa, H.; Nagata, M.; Uyama, T.; Shibata, T.; Kashiwa, Y.; Suzuki, S.; Kusama, Y.

    2006-01-01

    The compact toroid (CT) injection system for JFT-2M is composed of a CT injector, a gas delivery and vacuum system, a power supply system, and a diagnostics system. In particular, the power supply system delivers high performance for CT formation and acceleration. The CT formation capacitor bank unit achieved a formation current of 350 kA with a rise time less than 10 μs. Although the CT acceleration bank units are equipped with 14 ignitron switches instead of gap switches to attenuate the discharge noise level, an acceleration current of 400 kA with a short rise time of 9 μs is controlled within a jitter of much less than 1 μs. The resulting CT velocity and mass density satisfy the requirements for CT penetration into the tokamak plasma core at a toroidal field of 1 T. This CT injection system is thus suitable for CT injection in a middle-sized tokamak plasma such as the JFT-2M tokamak

  3. Combining 2-m temperature nowcasting and short range ensemble forecasting

    Directory of Open Access Journals (Sweden)

    A. Kann

    2011-12-01

    Full Text Available During recent years, numerical ensemble prediction systems have become an important tool for estimating the uncertainties of dynamical and physical processes as represented in numerical weather models. The latest generation of limited area ensemble prediction systems (LAM-EPSs allows for probabilistic forecasts at high resolution in both space and time. However, these systems still suffer from systematic deficiencies. Especially for nowcasting (0–6 h applications the ensemble spread is smaller than the actual forecast error. This paper tries to generate probabilistic short range 2-m temperature forecasts by combining a state-of-the-art nowcasting method and a limited area ensemble system, and compares the results with statistical methods. The Integrated Nowcasting Through Comprehensive Analysis (INCA system, which has been in operation at the Central Institute for Meteorology and Geodynamics (ZAMG since 2006 (Haiden et al., 2011, provides short range deterministic forecasts at high temporal (15 min–60 min and spatial (1 km resolution. An INCA Ensemble (INCA-EPS of 2-m temperature forecasts is constructed by applying a dynamical approach, a statistical approach, and a combined dynamic-statistical method. The dynamical method takes uncertainty information (i.e. ensemble variance from the operational limited area ensemble system ALADIN-LAEF (Aire Limitée Adaptation Dynamique Développement InterNational Limited Area Ensemble Forecasting which is running operationally at ZAMG (Wang et al., 2011. The purely statistical method assumes a well-calibrated spread-skill relation and applies ensemble spread according to the skill of the INCA forecast of the most recent past. The combined dynamic-statistical approach adapts the ensemble variance gained from ALADIN-LAEF with non-homogeneous Gaussian regression (NGR which yields a statistical mbox{correction} of the first and second moment (mean bias and dispersion for Gaussian distributed continuous

  4. Intelligent plasma operation and control system for HL-2M

    International Nuclear Information System (INIS)

    Xia, F.; Chen, L.Y.; Wang, C.; Zhang, G.; Song, X.M.; Song, X.; Pan, L.; Zhao, L.; Pan, W.; Lan, J.T.

    2015-01-01

    Full text of publication follows. The Intelligent Plasma Operation and Control System (IPOCS) for HL-2M is under construction based on the current actual situation of HL-2A control system in SWIP. The purpose of IPOCS is to replace the routine processes before, during and post discharge with the automatic process algorithms and give various information, for example, status, warning, reason, instruction, suggestion, physics phenomenon etc. to staff who can access the intranet. In this case, the core research objectives can be focused on and the related operations can be carried out referring to the information. The ultimate goal of IPOCS is to improve the efficiency of plant operation and control and physics research for HL-2M and for the fusion reactor in the future. There are three layers in IPOCS, which are named the information collection layer, the data processing layer and the presentation layer respectively. Information collection layer consists of data acquisition system, EPICS system, Audio and Video system, discharge scheduling system, data storage system etc. All raw data are collected and stored in this layer. The data processing layer is the core of IPOCS. Most algorithms are executed here. The basic computation platform is based on cluster (56 cores at present) and Parallel Computing Toolbox provided by Matlab. The physics database for SWIP based on HDF5 and offline EFIT also locate at this layer. All the operations can be finished during the time interval between two shots. The last layer is to present the information from the former two layers. The typical hardware including the large display screen system in the control room, the voice broadcasting system, personal monitors and smart phones, etc.. Several applications has being developed such as Control System Studio (CSS) in SWIP version, WebOPI, Automatic Alarm Display system and so on. IPOCS for HL-2M is at the very beginning phase at present. With more and more systems and algorithms got

  5. EFECTO DE UN PROGRAMA DE EJERCICIOS CON PESAS EN EL PORCENTAJE DE GRASA Y LA FUERZA EN MUJERES MAYORES

    Directory of Open Access Journals (Sweden)

    Magally Márquez Barquero

    2001-12-01

    Full Text Available El propósito del estudio fue determinar los efectos crónicos del entrenamiento con pesas sobre el porcentaje de grasa y la fuerza. Los participantes, de sexo femenino, entrenadas (n=10, edad 54.6 ± 4.19 años, un peso inicial promedio de 66.08 ± 12.50 Kg y una talla promedio de 1.585 ±0.0754 m., fueron divididos aleatoriamente en dos grupos: 50% de 5RM (n=5, 80% de 5 RM (n=5 y un pre test de registro de línea base. Las variables medidas fueron fuerza y porcentaje de grasa. Ambos grupos realizaron dos sesiones por semana durante doce semanas. Los ejercicios para ambos grupos fueron press de banca horizontal, extensión de rodilla, flexión de rodilla y jalón de polea frontal. El volumen de ejercicio total por sesión fue de 2550 unidades para el grupo que trabajo al 50 % (3 series x 17 rep. X 50% y 2560 para el que trabajo al 80% (4 series x 8 repeticiones x 80%. La fuerza se midió con el Test de 5 RM y el porcentaje de grasa fue estimado con la técnica de toma de siete pliegues cutáneos con el calibrador manual de piel marca Lange y subsecuentemente estimado usando la ecuación Leger y Cloutier para mujeres mayores de 50 años. Resultados: Para las pruebas de fuerza, press de banca, flexión de rodilla y extensión de rodilla hubo mejora significativa, tanto para el grupo que se ejercitó al 50 % como al 80 % de intensidad (p<0.05. Mientras que para la prueba halón de polea al frente el cambio entre mediciones (p<0.05, siendo mayor para el grupo que se ejercitó al 80 % de intensidad. En cuanto al porcentaje de grasa, disminuyó (p<0.05 similarmente a ambas intensidades de ejercicio. En conclusión, a intensidades del 50% como del 80% de 5RM, disminuye el porcentaje de grasa y aumenta la fuerza, en mujeres con una edad comprendida entre los 50 y 59 anos quienes realizaron una misma carga total de ejercicio con pesas. Los hallazgos sugieren que el entrenamiento con pesas a cargas altas, beneficia a los grandes grupos musculares.

  6. Data bank system in JFT-2M tokamak

    International Nuclear Information System (INIS)

    Takada, S.; Matsuda, T.; Miura, Y.; Mori, M.; Kawakami, T.; Matoba, T.

    1987-01-01

    It is very important to keep suitably and use effectively experimental data in the field of fusion research. The data bank system for fusion experiment can be classified into the following two forms, according to the type of their use: (1) Rapid Analysis Data Bank System; (2) High Quality Data Bank System. And their features are summarized. The data bank system of the former type was prepared for JFT-2M tokamak on the basis of the above classification. By introduction of this data bank system, the following results can be obtained: (1) Rationalization of data analyzing procedure; (2) Improvement of reliability by exclusion of bad data; (3) Easy expansions of analyzing function and tool development; (4) Space saving by extraction and compression of key information

  7. 6. Investigation of R2M17 compounds

    International Nuclear Information System (INIS)

    Elemans, J.B.A.A.; Buschow, K.H.J.

    1975-01-01

    A discussion is presented of the different crystallographic forms that arise in the parent RM 5 (R rare earth including yttrium or thorium; M = Fe, Co or Ni) with CaCu 5 structure in which every third R is replaced by a pair of M. This results in the stoichiometric composition R 2 M 17 . Metallographic studies of well annealed and quenched specimens of CeFesub(x), HoFesub(x) and TmFesub(x) with x varying from 8 to 9.5 showed that only those with x = 8.5 consisted of one phase. Similar experiments with ThNisub(x) and YNisub(x), x varying from 6.5 to 8.5 revealed that in these cases, single phases were obtained with x = 7.5

  8. Global magnetohydrodynamic instabilities in the L-2M stellarator

    Energy Technology Data Exchange (ETDEWEB)

    Mikhailov, M. I., E-mail: mikhaylov-mi@nrcki.ru [National Research Centre Kurchatov Institute (Russian Federation); Shchepetov, S. V., E-mail: shch@fpl.gpi.ru [Russian Academy of Sciences, Prokhorov General Physics Institute (Russian Federation); Nührenberg, C.; Nührenberg, J. [Max-Planck-Institut für Plasmaphysik (Germany)

    2015-12-15

    Analysis of global magnetohydrodynamic (MHD) instabilities in the L-2M stellarator (Prokhorov General Physics Institute, Russian Academy of Sciences) is presented. The properties of free-boundary equilibria states are outlined, the stability conditions for small-scale modes are briefly discussed, and the number of trapped particles is estimated. All the magnetic configurations under study are stable against ballooning modes. It is shown that global ideal internal MHD modes can be found reliably only in Mercier unstable plasmas. In plasma that is stable with respect to the Mercier criterion, global unstable modes that are localized in the vicinity of the free plasma boundary and are not associated with any rational magnetic surface inside the plasma (the so-called peeling modes) can be found. The radial structure of all perturbations under study is almost entirely determined by the poloidal coupling of harmonics. The results of calculations are compared with the available experimental data.

  9. La fuerza del espíritu (fe en el camino (ancestral indígena

    Directory of Open Access Journals (Sweden)

    Paola Andrea Pérez Gil

    2016-01-01

    Full Text Available El mundo de hoy se encuentra encerrado en la visión reduccionista y enajenada que ha sido imperante a lo largo de la historia, el valor del consumo, la ambición y el individualismo han enterrado los valores fundantes de sencillez, humildad y honestidad. La profunda necesidad de volver la mirada al conocimiento y psicología propios, ha hecho que retornemos a la sabiduría de las plantas, los abuelos, lugares sagrados, costumbres y mitos para abandonar la ilusión racionalista que todo lo divide, todo lo niega y nada lo contempla. El camino recorrido en el fuego, la montaña, Sie, el chunsúa, las cansamarias, permite mirar, recordar y recuperar lo fundamental en la existencia humana: su propia fuerza, la fe. Esa que sostiene la vida, que va más allá de verificación o comprobación alguna, que es cultivada en la palabra dulce, el tejido sentido y la esencia misma. Conectando al humano en sus diferentes niveles, a su psiquismo, conectándolo al amor. Por ello, la importancia de vivenciar a Sue, Chía, en y con la Hytcha Guaia, vivenciar al Espíritu en su expresión más latente, aceptar al ego como uno de los maestros para comprender el ser, integrar la materia y lo trascendente, entregarse a la ley de los abuelos, a lo sagrado propio, a la conciencia profunda, al guerrero interno, a la vida misma.

  10. Micro satellite instability in colorectal cancer stage II. Hospital Central de las fuerzas armadas

    International Nuclear Information System (INIS)

    Della Valle, A; Santander G; Camejo, N; Spera, G.

    2010-01-01

    Introduction: micro satellite instability (MSI) is a good prognostic factor in colorectal cancer (CRC) located. Its value as a predictive marker against adjuvant treatment of chemotherapy (CT) has been shown fluoropyrimidine in various publications. The MSI occurs in 15% of colorectal tumors and sporadic in 90% of tumors in the context of colorectal cancer syndrome hereditary nonpolyposis. In Uruguay there are no studies about this phenomenon. Objective: To determine the incidence of micro satellite instability in a sample of patients using the Hospital Central de las fuerzas armadas oncology service, association with a compatible family history and the histological features of the tumors associated therewith. Methods: The medical records of patients were analyzed with CRC diagnosed stage II between 01/2001 and 12/2009. Data of the patients were analyzed which had complete histology and evolution. Results: 30/52 patients (57.6%) were analyzed. 40% had a detected MSI by kits for Pcr (polymerase chain reaction) to D2S123, D5S250, D17S346, BAT25 and BAT26 according to the Bethesda criteria. In those patients they filed a MSI: the median age was 70 years; 58.3% male. No patient had a family history consistent with HNPCC. 5.6% (3) they received Adjuvant chemotherapy treatment. Regarding tumor characteristics: 75% (9) were T3, and T4 were 25% (3); 8.3% histologic grade I (1) II 58.3% (7) 8.3% III (1) without Data 33% (6). This tumor lymphocyte infiltration was reported in 25% (3), absent 33.3% (4), not reported in 41.6% (5). Conclusions: This is the first analysis of these characteristics carried out in Uruguay. The same has been detected MSI percentage higher than reported in the literature International. In either case a compatible family history met HNPCC

  11. Characteristics of modified CT injector for JFT-2M

    Energy Technology Data Exchange (ETDEWEB)

    Fukumoto, N. [Himeji Institute of Technology, 2167 Shosha, Himeji, Hyogo 671-2201 (Japan)]. E-mail: fukumoto@elct.eng.himeji-tech.ac.jp; Ogawa, H. [Japan Atomic Energy Research Institute (JAERI), 2-4 Shirakatashirane, Tokai-mura, Naka-gun, Ibaraki 311-0193 (Japan); Nagata, M. [Himeji Institute of Technology, 2167 Shosha, Himeji, Hyogo 671-2201 (Japan); Uyama, T. [Himeji Institute of Technology, 2167 Shosha, Himeji, Hyogo 671-2201 (Japan); Shibata, T. [Japan Atomic Energy Research Institute (JAERI), 2-4 Shirakatashirane, Tokai-mura, Naka-gun, Ibaraki 311-0193 (Japan); Kashiwa, Y. [Japan Atomic Energy Research Institute (JAERI), 2-4 Shirakatashirane, Tokai-mura, Naka-gun, Ibaraki 311-0193 (Japan); Kusama, Y. [Japan Atomic Energy Research Institute (JAERI), 2-4 Shirakatashirane, Tokai-mura, Naka-gun, Ibaraki 311-0193 (Japan)

    2004-10-01

    The HIT-CTI mark II compact toroid (CT) injector employed for the JFT-2M tokamak facility at the Japan Atomic Energy Research Institute (JAERI) has been upgraded to improve injection performance. The nozzle of the mark III injector now has a linear tube in place of the original focus cone to avoid rapid focus and deceleration, and the tapered outer electrode has been replaced with more gentle taper in the compression section in order to facilitate gradual compression. The dependence of CT velocity and electron density on poloidal bias flux and trigger time of CT acceleration have been investigated in the operable range of 70-230 km/s average CT velocity and electron density of 0.1-1.0 x 10{sup 22} m{sup -3} at an accelerator bank voltage of 25 kV. The operation window is broader than that of the mark II injector. Emission of a CT plasmoid from the injector, and transport to the flux conserver as a high-density spheromak magnetic structure have also been confirmed.

  12. Recent results of ECRH experiments on L-2M stellarator

    International Nuclear Information System (INIS)

    Shchepetov, S.V.; Akulina, D.K.; Batanov, G.M.

    1999-01-01

    Results are reported from experimental study of ECH heated plasma in the L-2M stellarator with special emphasis on studying the turbulent processes. It is shown that the total plasma energy at fixed total heating power is strongly dependent on the plasma position. Visible degradation of plasma confinement is observed for the inward shifted magnetic configurations where the stability conditions of ideal interchange MHD modes are violated. However, even in this case the situation can be improved by decreasing the average radius of the plasma boundary with the help of graphite limiter resulting in the increase of the Shafranov shift of magnetic surfaces and deepening of the magnetic well due to the effect of self-stabilization. This in turn causes stabilization of ideal MHD interchange modes and visible increase in plasma energy and volume average value of beta. Statistical properties of turbulence was studied both for the central part of the plasma column and for the plasma edge. It is shown that one of the critical factors determining the coherent structures and turbulent fluxes in the edge plasma is the radial electric field. (author)

  13. Fuerza de trabajo femenina en la agricultura de exportación de brócoli en Cotopaxi

    OpenAIRE

    Yumbla Mantilla, María Rosa

    2015-01-01

    En la provincia de Cotopaxi, el cultivo de brócoli se extiende principalmente en las parroquias de Guaytacama cantón Latacunga y en la parroquia Pujilí cantón Pujilí, territorios en los cuales al conformarse este agronegocio se genera una oferta y demanda de fuerza de trabajo espe- cialmente femenina, que bajo el estereotipo de ‘cualidades femeninas’ de docilidad y precisión son contratadas para cumplir altas normas de calidad exigidas por mercados internacionales. Se analiza las característi...

  14. ANÁLISIS DEL POTENCIAL COMPETITIVO DEL BIOETANOL EN COLOMBIA: UN ENFOQUE DESDE LAS 5 FUERZAS COMPETITIVAS DE MICHAEL PORTER

    OpenAIRE

    RAMIREZ VELASQUEZ ALEJANDRO; MONTOYA R. IVÁN ALONSO; MONTOYA RESTREPO ALEXANDRA

    2012-01-01

    La búsqueda de alternativas de producción y consumo energético requiere una mirada hacia la industria de los combustibles biológicos como el bioetanol que, como alternativa energética, permita superar los inconvenientes generados por los métodos tradicionales de producción y consumo, en especial en los temas políticos, ambientales y sociales y generar ventajas competitivas frente a otras fuentes primarias de energía. En el presente documento,a partir del modelo de las cinco (5) Fuerzas de Mic...

  15. Factores determinantes del rendimiento en el ejercicio de dominadas y efectos del entrenamiento concurrente de fuerza y resistencia

    OpenAIRE

    Sánchez Moreno, Miguel

    2017-01-01

    Programa de Doctorado en Actividad Física, Rendimiento Deportivo y Salud En la presente Tesis Doctoral se abordan una serie de problemáticas relacionadas, por una parte, con la mejora del entendimiento sobre aquellos factores que pueden ser determinante para el rendimiento en el ejercicio de dominadas y por otra parte, sobre cuestiones relacionadas con la influencia que puede tener la realización de dos grados de esfuerzo durante el entrenamiento de fuerza del miembro inferior sobre el re...

  16. Fuerzas producidas en un punto dentro de la masa del suelo debidas al peso del suelo y a las presiones del agua

    Directory of Open Access Journals (Sweden)

    Félix Hernández Rodríguez

    1991-09-01

    Full Text Available Buena parte de la labor del ingeniero de suelos radica en la evaluación de las reacciones en ciertos puntos de la masa de suelo. Esas reacciones, esfuerzo efectivo normal y esfuerzo portante, son el producto de las fuerzas de cuerpo que afectan los puntos en cuestión. Se presentan en el artículo los dos métodos de evaluación de esas reacciones: el método del peso unitario total y de las fuerzas periféricas del agua y el método del peso unitario sumergido y la fuerza de infiltración.

  17. Report ETSI M2M-14bis JTC March 2011 meeting

    NARCIS (Netherlands)

    Keesmaat, N.W.

    2011-01-01

    The ETSI Technical Committee (TC) M2M focuses on the development of a generic M2M architecture and underlying protocols suitable for a wide range of M2M environments. Whereas in the past effort has been put in the development of several use cases, the focus of this M2M 14bis meeting – held in Sophia

  18. ANÁLISIS DEL POTENCIAL COMPETITIVO DEL BIOETANOL EN COLOMBIA: UN ENFOQUE DESDE LAS 5 FUERZAS COMPETITIVAS DE MICHAEL PORTER

    Directory of Open Access Journals (Sweden)

    RAMIREZ VELASQUEZ ALEJANDRO

    2012-11-01

    Full Text Available La búsqueda de alternativas de producción y consumo energético requiere una mirada hacia la industria de los combustibles biológicos como el bioetanol que, como alternativa energética, permita superar los inconvenientes generados por los métodos tradicionales de producción y consumo, en especial en los temas políticos, ambientales y sociales y generar ventajas competitivas frente a otras fuentes primarias de energía. En el presente documento,a partir del modelo de las cinco (5 Fuerzas de Michael Porter, se realiza una evaluación de la industria del bioetanol como combustible alternativo y se expone qué tan atractiva o competitiva puede llegar a ser su industria en la actualidad. Para lograr este propósito, se propone una evaluación de las fuerzas competitivas a un panel de expertos, usando escalas deLikert, para encontrar el potencial de la propuesta.

  19. Revisión del alcance de los conceptos eficacia contractual, fuerza vinculante y relatividad de los contratos

    Directory of Open Access Journals (Sweden)

    Joaquín Quiró Saldaña

    2014-07-01

    Full Text Available Los institutos jurídicos tienen la particularidad de no ser inmutables, sino que, sus definiciones, y respectivos alcances, varían con el devenir del tiempo. Dichos cambios muchas veces obedecen al dictado de nuevas normas y otras, igualmente importantes, a la evolución de la ciencia jurídica y de la jurisprudencia las que, mediante la interpretación y sistematización de los preceptos jurídicos, le otorgan a los mismos sentidos muchas veces ni siquiera "soñados" por sus autores. Tomando como referencia este segundo punto de vista afrontamos el presente trabajo acerca de la eficacia de los contratos, su fuerza vinculante y la relatividad de los derechos emergentes del mismo con la intención de conferirles una dimensión diferente a la dada hasta el momento.Contenido: Introducción. El contrato como fuente de derecho objetivo. Ubicación del contrato en el sistema jurídico. Límites formales: análisis de los distintos escalones del ordenamiento jurídico. Límites materiales: determinación y clasificación. Eficacia contractual. Fuerza vinculante. Relatividad. Conclusiones

  20. ¿INSERCIÓN LABORAL DE LAS MUJERES EN AMÉRICA LATINA: UNA FUERZA DE TRABAJO SECUNDARIA?

    Directory of Open Access Journals (Sweden)

    Laís Abramo

    2004-01-01

    Full Text Available http://dx.doi.org/10.1590/S0104-026X2004000200013 El objetivo principal de este texto es discutir la aplicación de la noción de “fuerza de trabajo secundaria” para caracterizar la fuerza da trabajo femenina en América Latina. Esa caracterización, hecha con frecuencia en forma mecánica por un lado corresponde, cada vez menos a la realidad de los hechos, ya que es creciente la participación femenina en el mercado de trabajo, así como la continuidad de sus trayectorias laborales, el número de horas dedicadas al trabajo remunerado, así como su aporte al ingreso familiar y a la superación de la situación de pobreza de un porcentaje importante de hogares. Por otro lado, el texto argumenta que esa caracterización es uno de los elementos centrales en la estructuración de los patrones de discriminación de género que persisten y se reproducen en el mercado de trabajo latinoamericano.

  1. Efectos a Corto Plazo en Variables Cardiorrespiratorias de 2 Programas de Entrenamiento de Fuerza Prescribiendo Intensidad de Ejercicio con la RPE

    Directory of Open Access Journals (Sweden)

    José Luis Maté Muñoz

    2015-01-01

    Full Text Available El objetivo del estudio fue calcular las variables cardiorrespiratorias comparando un programa de entrenamiento de fuerza tradicional en condiciones estables con otro programa de fuerza en condiciones inestables, prescribiendo la carga de entrenamiento a partir de la escala de percepción subjetiva del esfuerzo. Se llevó a cabo un diseño aleatorio con grupo control asignando 36 hombres sanos a dos grupos experimentales (n = 24 y a un grupo control (n = 12, realizando dos entrenamientos de fuerza en circuito (ejercicios de fuerza con pesos libres y máquinas de musculación y ejercicios en BOSU® y TRX®. Los programas de fuerza duraron 7 semanas (3 sesiones por semana, midiendo las variables cardiorrespiratorias en un test de esfuerzo incremental pre y post entrenamiento. Para los valores de umbral ventilatorio 1, los resultados indicaron una reducción significativa de la frecuencia cardíaca después del período de entrenamiento tanto en el factor Tiempo (F = 12,777; p < 0,01 como en la Interacción (F = 4,718; p = 0,016, sin encontrar significación estadística entre los tres grupos (F = 1,279; p = 0,293. También se redujo significativamente el consumo de oxígeno a primer umbral, siendo esta disminución más acentuada en el grupo tradicional (F = 5,401; p = 0,027. Por tanto, se concluye que los valores de las variables cardiorrespiratorias después de 7 semanas de entrenamiento de fuerza en diferentes condiciones (estabilidad e inestabilidad y, prescribiendo las cargas de entrenamiento a través de la RPE, son similares.

  2. Experiencias en el desarrollo de una aplicación robótica con control de fuerza para taladrado de huesos

    Directory of Open Access Journals (Sweden)

    J.C. Fraile

    2008-04-01

    Full Text Available Resumen: En los sistemas de cirugía ortopédica asistida por ordenador (CAOS, el taladrado del hueso en la reparación de fracturas de huesos largos (para estabilizarlos con placas, clavos o tornillos es una tarea compleja que el cirujano debe realizar con gran precisión, evitando el calentamiento excesivo del tejido óseo. En la cirugía asistida por robots, se han utilizado principalmente robots industriales (Robodoc, Caspar, Crigos adaptados a ambientes quirúrgicos para ayudar al cirujano en esta tarea. En esta tarea de taladrado de huesos es necesario tener en cuenta varios factores: temperatura del hueso, velocidades de giro y avance de la herramienta de taladrado y fuerzas y pares que actúan sobre el hueso durante su taladrado.Es fundamental el desarrollo de algoritmos de control del robot manipulador para garantizar que las distintas variables que intervienen en el proceso de taladrado tomen los valores adecuados, bajo el control del cirujano, y así lograr una mayor calidad y precisión en la tarea quirúrgica de taladrado del hueso.Desafortunadamente, la mayoría de los robots industriales tienen una arquitectura de control propietaria que impide una fácil implantación de algoritmos de control externos basados en realimentación multisensorial (visión, fuerza.En este artículo se presenta el diseño de una arquitectura de control distribuido y abierto, que se ha implantado sobre el controlador de un robot Staubli. En ella se ha desarrollado una estrategia de control basada en realimentación de fuerza, que permite al cirujano realizar la tarea quirúrgica de taladrado del hueso con elevada precisión. Durante el taladrado con el robot, las fuerzas y pares que actúan sobre el hueso son medidos y utilizados para controlar la velocidad de avance de la herramienta de taladrado, y para controlar la fuerza aplicada al hueso. Se han obtenido resultados experimentales en condiciones de laboratorio con el manipulador equipado con un

  3. Métodos de entrenamiento de la fuerza para la mejora de las acciones en el fútbol [Strength Training Methods for Improving Actions in Football

    OpenAIRE

    Raya González, Javier; Sánchez Sánchez, Javier

    2018-01-01

    Debido a las características específicas del fútbol, donde las acciones de alta intensidad como saltos y cambios de dirección pueden llegar a ser factores determinantes para conseguir el éxito deportivo, incluir el entrenamiento de fuerza en las planificaciones de entrenamiento en fútbol se hace imprescindible. En función de las variables sobre las que se quiera incidir y del momento de la temporada, se deberá elegir un método de entrenamiento de la fuerza concreto, por lo que el conocimiento...

  4. Valoración de la intensidad del entrenamiento de fuerza a través de la velocidad en el aula

    OpenAIRE

    Sarabia, José Manuel; Hernández-Davó, Jose Luis; Javaloyes Torres, Alejandro; López-Grueso, Raúl; Sabido, Rafael

    2017-01-01

    El entrenamiento de fuerza ha recabado gran interés por la literatura científica en los últimos años, dada su importancia en campos tan dispares como el rendimiento deportivo, la calidad de vida en la tercera edad, o la mejora de patologías que se reflejan en la incapacidad funcional de los pacientes. Desde el punto de vista de la valoración y la planificación del entrenamiento de fuerza son distintas las variables claves que lo definen, ocupando especial relevancia la intensidad de dicho ent...

  5. Evolución de la pérdida de peso en dos personas sometidas a un programa de entrenamiento de fuerza con distintos ejercicios

    OpenAIRE

    Giménez Romo, Javier

    2014-01-01

    Objetivos: Evaluar la eficacia que tiene un entrenamiento de fuerza “tradicional”(ET)y un entrenamiento de fuerza con ejercicios más globales (EG) en dos personas distintas con obesidad para observar cuál de ellos es más efectivo tanto para la pérdida de grasa corporal como para la mejora del estado de forma. Y comparar el gasto energético que tienen estos dos tipos de entrenamiento. Conclusiones: Los resultados de este trabajo muestran que tanto un ET como un EG podrían ser efectivos par...

  6. Efectos de diferentes métodos de entramiento de fuerza y resistencia de agarre en escaladores deportivos de distintos niveles

    OpenAIRE

    López Rivera, Eva María

    2016-01-01

    Introducción:Hasta el momento la metodología y planificación de entrenamiento utilizada por los escaladores ha estado basada en la observación, intuición y en el ensayo-error. Numerosos estudios sugieren que la fuerza y resistencia de dedos es un factor de rendimiento en la escalada deportiva. Sin embargo, no hemos encontrado ningún trabajo que haya comparado y valorado los efectos de diferentes métodos de entrenamiento específico de fuerza y resistencia de dedos. El control de la carga es un...

  7. Efectos de un entrenamiento personalizado basado en la musculación sobre los niveles de fuerza y composición corporal de un sujeto activo

    OpenAIRE

    Paz Moraga, Francisco

    2014-01-01

    En el trabajo se realiza un repaso de los diferentes tipos de planificación, programación y periodización en el entrenamiento de fuerza, así como las diferentes metodologías existentes para el desarrollo de la misma en sujetos con experiencia en el entrenamiento con cargas. También se analizan los diferentes tipos de medición de la fuerza máxima y la composición corporal del sujeto durante el programa de entrenamiento. El objetivo fue conseguir un incremento de los niveles de f...

  8. Correlación entre los resultados de valoración funcional y de fuerza de la rodilla en pacientes con rotura del ligamento cruzado anterior

    OpenAIRE

    Álvarez Santana, David

    2016-01-01

    Programa de doctorado: Avances en Traumatología. Medicina del Deporte. Cuidado de Heridas. La fecha de publicación es la fecha de lectura [ES]Objetivos: Determinar si existen diferencias en la fuerza isométrica en la rodilla afecta con respecto a la sana en pacientes con rotura de LCA y un grupo control. Estudiar si existe correlación significativa entre el desplazamiento tibial, la fuerza isométrica generada por la musculatura de las rodillas, los resultados en cuestionarios de valoración...

  9. Efectos del HIIT en la composición corporal, potencia máxima y fuerza máxima : un estudio preexperimental

    OpenAIRE

    Jiménez Rodríguez, Francisco Miguel

    2013-01-01

    El principal objetivo de este estudio es conocer los efectos del HIIT en la composición corporal, fuerza dinámica (FDM) y potencia máxima (Pmáx) de miembro superior e inferior, potencia en saltos y fuerza máxima isométrica (FIM) manual. Cuatro hombres activos universitarios de similares características (21.5 ± 0.5 años, 175.75 ± 2.63 cm, 76.27 ± 4.76 kg) se ofrecieron como voluntarios para formar parte del estudio, un estudio preexperimental, sin grupo control, en el que realizaron un protoco...

  10. Determination of forces induced by steam flow in turbines; Determinacion de fuerzas inducidas por flujo de vapor en turbinas

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Castrejon, Juan Carlos

    2008-09-15

    rotor, lo que lleva a fracturas de los componentes por fatiga. Este trabajo estudia y calcula las fuerzas de excitacion de las vibraciones inducidas por flujo. Se realiza el analisis del flujo, en dos etapas diafragma-rotor de una turbina de vapor, con base en el Modelado Computacional de Dinamica de Fluidos (MCDF). Las etapas de la turbina bajo estudio son la primera etapa o paso Curtis y la ultima etapa o etapa de baja presion de la Turbina. El paso Curtis esta formado por alabes pequenos y el flujo esta sometido a altas presiones. El ultimo paso esta compuesto por alabes grandes y el flujo esta sometido a bajas presiones. El MCDF resuelve numericamente las ecuaciones que representan la dinamica de fluidos y se obtiene la variacion del campo de presion en el claro axial rotor-estator causada por la interaccion de las estelas del borde de salida de los diafragmas con el movimiento de los alabes. La variacion del campo de presion induce fuerzas en los alabes ocasionando vibraciones forzadas. En cada una de las etapas se realizaron simulaciones en 2D y 3D, que se resolvieron en funcion del tiempo, usando el modelo de turbulencia RNG - y la tecnica de malla deslizante, para simular el movimiento de los alabes. Los modelos en 3D se resolvieron usando computo en paralelo en un cluster compuesto por 6 procesadores AMD Optaron e 64 bits, 2412.36 MHz y 8Gb de memoria RAM. Los resultados de las simulaciones en las dos etapas, permitieron obtener el comportamiento del campo de presion en el claro axial tobera-rotor y las fuerzas que este campo induce sobre los alabes. La fuerza sobre los alabes fue calculada usando un codigo que se ejecutaba en cada paso temporal de la simulacion, esta fuerza fue posteriormente analizada usando la transformada rapida de Fourier para obtener la fuerza sobre los alabes como una expresion matematica. Usar el MCDF para obtener las fuerzas que actuan sobre los alabes y que son inducidas por flujo representa una ventaja sobre otros metodos de calculo

  11. Relación entre potencia máxima, fuerza máxima, salto vertical y sprint de 30 metros en atletas cuatrocentistas de alto rendimiento

    Directory of Open Access Journals (Sweden)

    Carlos Balsalobre-Fernández

    2012-06-01

    Full Text Available Mediante un diseño ex post facto y valiéndose de una muestra de catorce atletas cuatrocentistas de alto rendimiento, entre los que se encuentran diferentes medallistas nacionales del Estado Español, este estudio hace tres aportaciones: la primera, describe la fuerza de extremidades inferiores de este colectivo y su capacidad de aceleración en 30 metros; la segunda, informa de la relación de covariación entre, por una parte, la variable potencia y, por otra, la fuerza máxima, la fuerza explosiva y la capacidad de aceleración, encontrándose correlaciones significativas con valores entre 0,60 y 0,81; y la tercera, se demuestra que la potencia máxima de estos deportistas se encuentra entre el 50 % y el 70 % de su Repetición Máxima en media sentadilla. Asimismo, se discuten los resultados y se argumenta que el entrenamiento de la fuerza es una condición necesaria para mejorar el rendimiento deportivo de alto nivel, postulando que los datos sobre potencia máxima encontrados en este estudio ayudarán a técnicos y deportistas a planificar sus cargas óptimas de entrenamiento.

  12. Fuerza muscular, flexibilidad y postura en la prevalencia de dolor lumbar de los tripulantes de helicópteros del Ejército Nacional de Colombia

    Directory of Open Access Journals (Sweden)

    Imma Caicedo Molina

    2013-10-01

    Full Text Available Objetivo. Determinar la relación entre la fuerza muscular, la flexibilidad y la postura con la prevalencia de dolor lumbar en los tripulantes de helicópteros del Ejército Nacional de Colombia. Materiales y métodos. Se realizó un estudio de tipo transversal bajo un modelo de regresión logística múltiple, enfocado en la medición de la fuerza muscular, la flexibilidad y la postura en tripulantes de helicópteros del Ejército Nacional de Colombia. Resultados. 108 tripulantes fueron evaluados, de quienes el 59,3 % presentó dolor lumbar. Se encontró que la fuerza de los músculos extensores de tronco constituyó un factor de protección (OR= 0,98. p0,05 y OR=1,04, p<0,05, Chi cuadrado 2,80 respectivamente. Conclusión. La fuerza muscular adecuada de los extensores de tronco constituye un factor protector frente al dolor lumbar en los tripulantes de helicópteros. Sin embargo, es necesario desarrollar más investigaciones en esta población que permitan mayor comprensión de los factores relacionados con el dolor. Las variables intervinientes de contexto, junto con las variables fisiocinéticas, constituyen una red compleja de determinantes del dolor lumbar en los tripulantes de helicópteros.

  13. EFECTO DE UN ESTÍMULO AGUDO DE HIPOXIA SOBRE LA VELOCIDAD DE MOVIMIENTO EN UN EJERCICIO DE FUERZA DEL TREN SUPERIOR

    Directory of Open Access Journals (Sweden)

    Ismael Martínez-Guardado

    2015-04-01

    Full Text Available En general, el entrenamiento de fuerza tiene un potente efecto para incrementar el tamaño y la fuerza del músculo esquelético (Kraeme, Fleck & Evans, 1995. El uso de un estímulo de hipoxia durante el entrenamiento comenzó a desarrollarse a través de técnicas de restricción del flujo sanguíneo (Takarada et al., 2000. Un estímulo similar lo podemos llevar a cabo mediante el uso de cámaras de hipoxia y a través de sistemas de entrenamiento intermitente (Lundby, Calbet, Robach, 2009. La adicción de este estímulo hipóxico al entrenamiento podría incrementar la hipertrofia muscular y la ganancia de fuerza.Objetivo: Analizar los efectos de un entrenamiento de fuerza del tren superior en condiciones de hipoxia sobre el número de repeticiones y la velocidad del movimiento.

  14. Fuerza Aérea Colombiana: El cuadro de mando integral, orientación para su aplicación en la institución

    Directory of Open Access Journals (Sweden)

    Andrés Velásquez

    2006-07-01

    Full Text Available Caso de aplicación del Cuadro de Mando Integral para que los gerentes de las empresas colombianas conozcan sus bondades y establezcan un contraste con una aplicación en una organización altamente jerárquica como la Fuerza Aérea Colombiana

  15. Efecto de 24 sesiones de entrenamiento de fuerza en un paciente con gonartrosis bilateral: a propósito de un caso

    Directory of Open Access Journals (Sweden)

    O. Abrahin

    2015-03-01

    Conclusión: Los resultados de este estudio indican que 24 sesiones de EF progresivo pueden ser eficaces en la mejora de índices antropométricos, la capacidad funcional y la fuerza muscular de un paciente anciano diagnosticado de GA bilateral.

  16. Espacio y honra en “La fuerza de la sangre” y “El celoso extremeño”.

    Directory of Open Access Journals (Sweden)

    Daniel R. Walker.

    2009-01-01

    Full Text Available Resumen: En las Novelas ejemplares, Cervantes cuestiona algunos de los paradigmas sociales más centrales del Siglo de Oro español, subvirtiendo sus premisas y haciendo visibles los esqueletos de su construcción. Este proceso de divulgación tiene el fin de hacer patentes los mecanismos complicados de un concepto tan intrínsicamente encerrado en la conciencia colectiva de la época como el de la honra. Mientras que en sus obras el dramaturgo Lope de Vega opta por reforzar los cimientos de este concepto por medio de la puesta en escena de una ideología conservadora que sutura casi perfectamente las cicatrices de su práctica, Cervantes, en cambio, no intenta ocultar la base de sus raíces. Es sobre todo en La fuerza de la sangre y El celoso extremeño donde se muestra la artificialidad misma del concepto por su curiosa espacialización. Es decir, dentro de estas novelas, la honra opera según su ubicación espacial y sus connotaciones cambian dependiendo del espacio de los acontecimientos de los relatos. Esta fragmentación de un concepto supuestamente unido y totalizador lo desestabiliza y deja la noción de la honra completamente subvertida. Mientras que La fuerza de la sangre demuestra una marcada diferencia entre la honra pública y la honra privada a través de la meticulosa construcción de los varios entornos del relato, El celoso extremeño pone de relieve que en realidad el único espacio de la honra es el de la imaginación. La inestabilidad y el carácter efímero de la honra llegan a ser el centro de las ficciones, cuestionando así la ideología dominante estabilizadora que generalmente tenía la honra como uno de sus epicentros más fuertes.Summary: In his Novelas ejemplares, Cervantes questions some of the most important social paradigms of the Spanish Golden Age, subverting their premises and making visible the framework of their construction. In the end, this process of revelation sheds much light on the complicated

  17. La gestión en seguridad aérea en la Fuerza Aérea Colombiana

    Directory of Open Access Journals (Sweden)

    Eduardo Behar Benítez

    2006-01-01

    Full Text Available La reestructuración de la Fuerza Aérea Colombiana obedece a una decisión estratégica establecida bajo el principio institucional de disposición al cambio, el cual se define como un estado mental que permite abrir el entendimiento de manera amplia para escuchar y evaluar a conciencia y sin prejuicios, nuevas propuestas para adaptar los comportamientos a las circunstancias de un mundo en permanente cambio e incertidumbre, cada vez más apoyado en la tecnología y telecomunicaciones que trascienden las barreras geográficas tradicionales.

  18. Efectos de un programa de flexibilidad en el desarrollo de la fuerza muscular en jugadoras de futbol

    Directory of Open Access Journals (Sweden)

    José E. Del Río Valdivia

    2015-12-01

    Full Text Available Se analizó el impacto de un programa de entrenamiento de flexibilidad sobre el desarrollo de la fuerza muscular en 16 jugadores de futbol con edad de 19.03±2.7 años. Se entrenó durante 30 días y 5 veces por semanas, donde el grupo “A” realizó  entrenamiento de flexibilidad, mientras que “B” el entrenamiento regular. Se midió la flexibilidad, 1RM, salto vertical, peso, talla, circunferencia de pantorrilla y muslo. Los resultados muestran  valores para A y B respectivamente, donde el IGF fue de 91.01 ± 18.3 y 111.93 ± 23.5;  78.22 ± 29, y  79.03 ± 29.1. La circunferencia femoral, 48.04 ± 3.6 cms y 49.54 ± 3.4 cms.; 47.56 ± 4.9 y 47.89 ± 5.2. Circunferencia de pantorrilla, 33.83 ± 2.7 cm y 35.21 ± 2.4 cm; 33.83 ± 2 y 33.73 ± 2.8. Fuerza  48.13 ± 7.8 Kg. y 53.38 ± 8.2 Kg.; 52.63 ± 8.6 Kg. y 53.39 ± 9.1 Kg. Potencia anaeróbica, 34.13 ± 2.9 cm. y 36.63 ± 1.7 cm; 38.25 ± 4.7 y 37.06 ± 3.4. Como conclusión se tiene que el  uso la  flexibilidad impacta de forma  positiva en el  IGF y por tanto en el desarrollo favorable muscular de jugadoras de futbol.

  19. Rivas y Verdi: Las trampas de la libertad en La fuerza del sino y La forza del destino

    Directory of Open Access Journals (Sweden)

    Egido, Aurora

    2012-06-01

    Full Text Available A comparative analysis between Duque de Rivas’Don Álvaro o la fuerza del sino and La forza del destino by Giuseppe Verdi shows, even in their very titles, the close relationship between Spain and Italy since the days of the Golden Age. Both works posit the old theological problem of compatibility between predestination and free will, while adding new social and political insights into social and racial differences and highlighting the narrowness of the code of honour. Otherwise, as far as the admixture of genres or the treatment of costumbrismo and nationalism are concerned, the difference between both works increases in the second version of Verdi´s opera, in which the alteration of the denouement wipes out the tragical dimension of the spanish play.Un análisis comparativo entre Don Álvaro o la fuerza del sino del duque de Rivas y La forza del destino de Giuseppe Verdi demuestra, ya desde sus títulos, un viaje de y vuelta entre España e Italia que tiene como fondo la literatura del Siglo de Oro. Ambas obras plantean el viejo problema entre providencia y libertad, añadiendo nuevos relieves sociales y políticos sobre las diferencias de clase y raza que ponen en evidencia las estrecheces del código del honor. Las diferencias entre ambas —más allá de la mezcla genérica, el tratamiento costumbrista y el nacionalismo— se acentúan en la segunda versión de la ópera verdiana, que, al cambiar el desenlace, destruyó el sentido trágico del drama español.

  20. Un acercamiento a la fuerza pública en los estados de Cundinamarca y Santander, 1857-1885

    Directory of Open Access Journals (Sweden)

    Yaneth Cristina Mendoza Chacón

    2011-01-01

    Full Text Available El presente trabajo tuvo como objetivo producir una representación histórica sobre la estructura, el funcionamiento y las transformaciones de la Fuerza Pública en los Estados de Cundinamarca y Santander, durante el período 1857-1885, mediante el seguimiento de sus aspectos administrativos, así como la evolución, organización, composición y distribución de sus efectivos armados, a través del seguimiento a su forma constitucional o legal. Se presentan las bases constitucionales que sostuvieron al cuerpo militar, y se analiza hasta qué punto lograron cumplirse, de tal forma que se pudo demostrar la doble dinámica en que funcionó el cuerpo armado del Estado, girando entre un carácter militar y sus funciones de control civil del orden público. Al conocerse la evolución del Ejército seccional, se pudieron comprender los resultados que dejó la experiencia federal en las instituciones nacionales, especialmente en la militar, demostrándose una vez más, que la irregularidad del presupuesto y la subordinación del poder militar al civil, generaron las mayores contradicciones del cuerpo armado. Sin embargo, tal experimento sirvió para demostrar cuán necesaria fue la presencia de Fuerza Pública, pues a pesar de los inconvenientes que presentó el período, con sus doctrinas liberales, llevadas al extremo, la institución logró mantenerse, medianamente, hasta el tiempo en que llegó su Reforma Militar.

  1. Vigencia del método de Roth para la determinación de fuerzas de cortocircuito en devanados de transformadores

    Directory of Open Access Journals (Sweden)

    Guillermo Andrés Aponte Mayor

    2018-01-01

    Full Text Available Contexto: Debido a la dificultad para realizar la prueba de aptitud al cortocircuito en transformadores de gran potencia, la norma IEC 60076-5 2006 de la Comisión Electrotécnica Internacional acepta como método alternativo la estimación de las fuerzas y esfuerzos a través de cálculo y consideraciones de diseño. Método: En este artículo se presenta la implementación del método analítico de Roth para el cálculo de las fuerzas axiales y radiales de cortocircuito en un transformador trifásico con núcleo tipo columnas de 630kVA. Resultados: Las fuerzas máximas obtenidas con el método de Roth son comparables con las calculadas a través de métodos modernos para el diseño de transformadores como el método de elementos finitos, las diferencias entre los cálculos fueron mínimas a excepción de la fuerza axial máxima del devanado de baja tensión. Conclusiones: Aunque el método de Roth es una herramienta tradicional para solución de problemas de electromagnetismo, este es adecuado para hacer una estimación rápida y sencilla de parámetros magnéticos y fuerzas de cortocircuito en transformadores.

  2. Efectividad de un protocolo de entrenamiento nórdico sobre la fuerza explosiva en futbolistas del Club Deportivo La Equidad Seguros

    Directory of Open Access Journals (Sweden)

    Érica Mabel Mancera-Soto

    2016-09-01

    Full Text Available Introducción. El entrenamiento nórdico ha sido estudiado para optimizar el gesto deportivo y prevenir lesiones en fútbol. Sin embargo, no se han reportado estudios que evidencien su efectividad sobre la fuerza explosiva del deporte. Objetivo. Determinar la efectividad de un protocolo de entrenamiento nórdico sobre la fuerza explosiva de miembros inferiores en futbolistas. Materiales y métodos. Se realizó un ensayo controlado y aleatorizado en el que 26 futbolistas masculinos fueron elegidos para hacer parte de un grupo intervención (n=12 y un grupo control (n=14. Al grupo intervención se le aplicó un protocolo de entrenamiento nórdico, mientras que el control realizó un programa de fortalecimiento convencional. Se evaluaron la fuerza explosiva de miembros inferiores, a través del Test de Bosco y Abalakov en una plataforma de salto, y el ángulo de mayor reclutamiento muscular del bíceps femoral durante la ejecución del ejercicio nórdico mediante de electromiografía de superficie. Resultados. Los dos grupos fueron homogéneos. Se evidenció una mejora en los componentes de la fuerza explosiva (p<0.05 para las variables de velocidad de despegue, de reclutamiento motor y de ángulo de registro del pico de reclutamiento motor en el grupo de intervención. Conclusión. La aplicación de un programa de entrenamiento en futbolistas demostró ser efectiva al influir de manera positiva en las variables involucradas en la fuerza explosiva.

  3. Machine-to-Machine networks: integration of M2M networks into companies' administrative networks

    OpenAIRE

    Pointereau, Romain

    2013-01-01

    This analysis will address the technical, economic and regulatory aspects and will identify the position taken by the various market actors. Integration of M2M Networks into Companies' Administrative Networks. Integración de redes M2M en redes administrativas de las empresas. Integració de xarxes M2M en xarxes administratives de les empreses.

  4. Independent working place on the base of the DVK-2M computer and UNO-4096 analyzer

    International Nuclear Information System (INIS)

    Zajtsev, M.Yu.; Balandin, A.F.

    1987-01-01

    Independent working place on the base of the DVK-2M microcomputer and UNO-4096-90 analyzer, designated for investigations of the field of reactor and protection physics is described. Two ways of the analyzer connection with the DVK-2M microcomputer are suggested : by means of CAMAC system or direct connection of UNO-analyzer with the DVK-2M processor

  5. An explanation of the preferential formation of less stable isomers in three-body reactions - Cl + NO2 + M ClO + NO2 + M

    International Nuclear Information System (INIS)

    Chang, J.S.; Baldwin, A.C.; Golden, D.M.

    1979-01-01

    A realistic assessment of the potential depletion of stratospheric ozone due to manmade emissions requires a knowledge of the sources and sinks of the potential threat. The reactions ClO + NO 2 + M yield products and Cl + NO 2 + M yield products are of interest because they represent possible sink mechanism for both odd chlorine and odd nitrogen species. In this paper, the Troe method (1977) is used to calculate the low-pressure limit rate constants of the above three-body reactions. The result for the Cl + NO 2 + M reaction is found to be in excellent agreement with the experimental finding of Niki et al. (1978), where both nitryl chloride and chlorine nitrate are products of the cited reaction. An explanation is proposed to account for apparent discrepancy between the measured rate constants for ClO + NO 2 + M in the forward and reverse directions. Stratospheric implications are also discussed

  6. Comparison of monoclonal antibodies and rabbit antisera in B2 microglobulin (B2m) radioimmunoassay

    International Nuclear Information System (INIS)

    Vincent, C.

    1981-01-01

    Human B2m is a globular protein devoid of carbohydrates and is composed of 100 aminoacids with an intrachain disulfide bridge in position 25-81. Its aminoacid sequence and three dimensional structure shows a partial homology with the constant domains of immunoglobulins. B2m has been detected at the surface of nearly all cell types with the exception of erythrocytes and trophoblastic cells and also in all biological fluids. On the cell surface B2m is found non-covalently associated with HLA molecules, and in serum and urine only a small part of the B2m is associated with HLA heavy chain, the remaining is found as free B2m. The aim of this paper is firstly to try to demonstrate the presence of two types of epitopes one of them specific of free B2m and secondly to compare monoclonal antibodies with rabbit antisera for B2m radioimmunoassay. (Auth.)

  7. Periodización del entrenamiento de fuerza y resistencia en piragüistas de alto nivel

    Directory of Open Access Journals (Sweden)

    Jesús García-Pallarés

    2010-09-01

    Full Text Available Este estudio examinó en un grupo de 18 kayakistas varones de alto nivel (incluidos 11 medallistas de Campeonatos del Mundo o de Europa y dos Campeones Olímpicos los cambios en variables cardiorrespiratorias, neuromusculares, hormonales, composición corporal y de rendimiento durante un ciclo de 12 semanas de entrenamiento concurrente de fuerza y resistencia cardiovascular. Así mismo se analizaron los efectos producidos por un periodo de 4 semanas de puesta a punto (TAP y una fase de desentrenamiento (DTR de 5 semanas en la que la mitad de los palistas cesaron totalmente los estímulos de entrenamiento (CE y la otra mitad realizó únicamente una sesión de entrenamiento de fuerza y dos de resistencia semanales (RE. El volumen y la intensidad de entrenamiento fueron cuantificados a nivel individual durante todas las fases del estudio. El ciclo periodizado de entrenamiento concurrente de 12 semanas produjo aumentos significativos de un 9,5% en el consumo máximo de oxígeno (VO2max y de un 9,4% y en el consumo de oxígeno en el segundo umbral ventilatorio (VO2 VT2. La velocidad de desplazamiento en VO2max, y en VT2 aumentó un 6,2% y un 4,4% respectivamente. Los valores de una repetición máxima (1RM aumentaron un 4,2% en press banca (PB y un 5,3% en dorsal remos (DR, mientras que la velocidad con el 45% del 1RM (V45% aumentó un 14,4% en PB y un 10,0% en DR. Tras la fase de TAP no se observaron cambios significativos en ninguna de las variables estudiadas. Durante la fase de DTR, el grupo de CE mostró mayores descensos del 1RM (–8,9% y –7,8%, para el PB y el DR respectivamente que los observados para el grupo de RT (–3,9% y –3,4%. Los descensos en la V45% en el PB y el DR fueron mayores para el grupo de CE (–12,6% y –10,0% que para el grupo RE (–9,0% y –6,7%. Los descensos en el VO2max fueron menores tras la RE (–5,6% que tras la CE (–11,3%, aunque las pérdidas en VO2 VT2 fueron similares en ambos grupos. La fase de RE

  8. Plataforma productiva como fuerza del desarrollo endógeno del sector de manufacturas plásticas

    Directory of Open Access Journals (Sweden)

    Maryana Sandrea

    2014-01-01

    Full Text Available La plataforma productiva de una localidad constituye un soporte a la actividad empresarial, en términos de infraestructura física y servicios conexos, que dependiendo de sus condiciones estimula o frena el desarrollo endógeno. En este contexto, el objetivo general de la investigación consiste en analizar las condiciones de la plataforma productiva como fomento al desarrollo endógeno, en el sector de manufacturas plásticas, utilizando básicamente los aportes de Vázquez (2005 y 2007. El estudio realizado es descriptivo y de campo, con un diseño transversal, no experimental, incluyendo una entrevista a 30 empresas, guiada con un formato estructurado. Entre los resultados destacan: el 56,7% de los entrevistados presentan una posición desfavorable, en cuanto a las condiciones de la plataforma de apoyo al proceso productivo como estímulo al desarrollo del sector en la región, un 63,4% de los consultados afirman que la infraestructura física para el traslado de mercancías no favorecen la actividad del sector. La mayoría (76,7% de los entrevistados consideró que el funcionamiento de los servicios administrativos del gobierno, constituye un soporte valioso a las actividades empresariales, especialmente en cuanto a la posibilidad de realizar trámites vía Internet. Para la mayoría de las empresas consideradas (60%, el desarrollo urbano del territorio se presenta como una fuerza relativamente débil en el entorno productivo. Se concluye, que la relativa debilidad de ésta fuerza en la región, obedece a las deficiencias en las condiciones de la infraestructura económica, en particular al mantenimiento de la red de carreteras secundarias, así como en la prestación del servicio eléctrico, mientras que la infraestructura institucional resultó fortalecida, por tanto, para elevar el grado de desarrollo será necesario realizar intervenciones a fin de mejorar las condiciones de la infraestructura económica.

  9. Ejercicio aeróbico y de fuerza en personas con una enfermedad pulmonar obstructiva (epoc: estudio de caso

    Directory of Open Access Journals (Sweden)

    Lara Blas

    2016-12-01

    Full Text Available El objetivo del estudio fue describir las respuestas fisiológicas de pacientes con EPOC en cada una de las sesiones de un programa de entrenamiento físico de ocho semanas y analizar los efectos producidos por el programa en el rendimiento físico de estos pacientes. En este estudio participaron cuatro personas a las que se les diagnosticó EPOC (64±6 años. Se realizó un test (T1 de 6 minutos de caminata (6MWT para determinar la capacidad cardiovascular de los participantes y, después de ocho semanas, se volvió a repetir el mismo test (T2. Durante las ocho semanas se llevó a cabo trabajo de resistencia aeróbica e interválica, de fuerza, estiramientos y trabajo de musculatura respiratoria. No se observó un aumento significativo en las variables fisiológicas (tensión sistólica, tensión diastólica y saturación de oxígeno tras la realización del 6MWT ni en el T1 ni en el T2. Sin embargo, la tensión sistólica, tanto en el Post test del T1 (∆%=24.8±22.1; TE=2.2, alto como en el Post test del T2 (∆%=14.0±13.2; TE=1.0, alto, presentó una tendencia a ser superior con respecto al Pre test, en ambos casos. Por otro lado, los participantes recorrieron ligeramente más metros después de 8 semanas de intervención (∆%=4,61; TE=0.4, bajo, lo cual se acompañó, de una mayor percepción del esfuerzo (∆%=107.1; TE=3.0 y ∆%=200.0; TE=1.8 para RPEmus. Los participantes en este estudio obtuvieron una ligera mejora en el rendimiento físico en el test 6MWT, posiblemente debido a que las sesiones no se enfocaron solamente en la mejora de la capacidad aeróbica, sino también en la mejora de la fuerza muscular.

  10. Plataforma productiva como fuerza del desarrollo endógeno del sector de manufacturas plásticas

    Directory of Open Access Journals (Sweden)

    Maryana Sandrea

    2014-01-01

    Full Text Available La plataforma productiva de una localidad constituye un soporte a la actividad empresarial, en términos de infraestructura física y servicios conexos, que dependiendo de sus condiciones estimula o frena el desarrollo endógeno. En este contexto, el objetivo general de la investigación consiste en analizar las condiciones de la plataforma productiva como fomento al desarrollo endógeno, en el sector de manufacturas plásticas, utilizando básicamente los aportes de Vázquez (2005 y 2007. El estudio realizado es descriptivo y de campo, con un diseño transversal, no experimental, incluyendo una entrevista a 30 empresas, guiada con un formato estructurado. Entre los resultados destacan: el 56,7% de los entrevistados presentan una posición desfavorable, en cuanto a las condiciones de la plataforma de apoyo al proceso productivo como estímulo al desarrollo del sector en la región, un 63,4% de los consultados afirman que la infraestructura física para el traslado de mercancías no favorecen la actividad del sector. La mayoría(76,7% de los entrevistados consideró que el funcionamiento de los servicios administrativos del gobierno, constituye un soporte valioso a las actividades empresariales, especialmente en cuanto a la posibilidad de realizar trámites vía Internet.Para la mayoría de las empresas consideradas (60%, el desarrollo urbano del territorio se presenta como una fuerza relativamente débil en el entorno productivo.Se concluye, que la relativa debilidad de ésta fuerza en la región, obedece a las deficiencias en las condiciones de la infraestructura económica, en particular al mantenimiento de la red de carreteras secundarias, así como en la prestación del servicio eléctrico, mientras que la infraestructura institucional resultó fortalecida, por tanto, para elevar el grado de desarrollo será necesario realizar intervenciones a fin de mejorar las condiciones de la infraestructura económica.

  11. Distributed Energy-Efficient Topology Control Algorithm in Home M2M Networks

    OpenAIRE

    Lee, Chao-Yang; Yang, Chu-Sing

    2012-01-01

    Because machine-to-machine (M2M) technology enables machines to communicate with each other without human intervention, it could play a big role in sensor network systems. Through wireless sensor network (WSN) gateways, various information can be collected by sensors for M2M systems. For home M2M networks, this study proposes a distributed energy-efficient topology control algorithm for both topology construction and topology maintenance. Topology control is an effective method of enhancing e...

  12. Development of the JFT-2M data analysis software system on the mainframe computer

    International Nuclear Information System (INIS)

    Matsuda, Toshiaki; Amagai, Akira; Suda, Shuji; Maemura, Katsumi; Hata, Ken-ichiro.

    1990-11-01

    We developed software system on the FACOM mainframe computer to analyze JFT-2M experimental data archived by JFT-2M data acquisition system. Then we can reduce and distribute the CPU load of the data acquisition system. And we can analyze JFT-2M experimental data by using complicated computational code with raw data, such as equilibrium calculation and transport analysis, and useful software package like SAS statistic package on the mainframe. (author)

  13. DETERMINACIÓN DE LA FUERZA DE LA FRACTURA SUPERFICIAL Y FUERZA DE FIRMEZA EN FRUTAS DE LULO (Solanum quitoense x Solanum hirtum DETERMINATION OF SURFACE FRACTURE AND FIRMNESS FORCE IN LULO FRUIT (Solanum quitoense x Solanum hirtum

    Directory of Open Access Journals (Sweden)

    Diana Marcela Ospina Monsalve

    2007-12-01

    Full Text Available Se hizo la caracterización reológica de la fruta de lulo (Solanum quitoense x Solanum hirtun a través de la respuesta mecánica bajo ensayos de compresión unidireccional a pruebas de firmeza y fractura, de acuerdo a dos grados de madurez comercial (pintón y maduro y tiempos de poscosecha (0, 3, 6, 9 días. Adicionalmente se determinaron propiedades físico-químicas tales como concentración de azúcares, pH y color. Las frutas fueron sometidas a ensayos de compresión unidireccional usando un analizador de textura a una velocidad de deformación de 1 mm∙s. Los ensayos para la prueba de fractura se realizaron según dos sentidos de carga (longitudinal y transversal y la prueba de firmeza se determinó en dos ángulos de incidencia. Los resultados mostraron que el comportamiento reológico de la fruta a ensayos de fractura y firmeza es altamente dependiente del tiempo transcurrido después de la cosecha de la fruta y condiciones fisiológicas (grado de madurez, situación ésta que refleja el comportamiento visco elástico y anisotrópico del producto. Los valores de la fuerza de fractura indicaron que la fruta pintona resiste mayor carga de aplastamiento con respecto al fruta madura. La fruta resiste más carga en sentido longitudinal que transversal, mostrando valores para frutas pintonas en posición longitudinal de 226 N y en posición transversal de 84,8 N, y para las frutas maduras se encontró una fuerza de fractura media en posición longitudinal de 180 N y en posición transversal de 68,5N. Para la fuerza de firmeza media (pulpa el valor máximo para frutas maduras fue de 1,4 N, y para frutas pintonas de 1,1 N. La fuerza de firmeza máxima (epicarpio tomó como valores máximos para las frutas maduras 14,4 N y para los frutas pintonas de 15,7 N.A rheological characterization of lulo fruits (Solanum quitoense x Solanum hirtum by using the test of unidirectional compression to firmness and fracture tests, according to two degrees of

  14. Reliable Reporting for Massive M2M Communications with Periodic Resource Pooling

    DEFF Research Database (Denmark)

    Madueño, Germán Corrales; Stefanovic, Cedomir; Popovski, Petar

    2014-01-01

    This letter considers a wireless M2M communication scenario with a massive number of M2M devices. Each device needs to send its reports within a given deadline and with certain reliability, e.g., 99.99%. A pool of resources available to all M2M devices is periodically available for transmission...... to guarantee the desired reliability of the report delivery within the deadline. The fact that the pool of resources is used by a massive number of devices allows to base the dimensioning on the central limit theorem. The results are interpreted in the context of LTE, but they are applicable to any M2M...

  15. Core fuel management using TVS-2M fuel assembly and economic analysis

    International Nuclear Information System (INIS)

    Xu Min; Wang Hongxia; Li Youyi

    2014-01-01

    To improve the economic efficiency, TVS-2M fuel assembly was considered to apply in Tianwan Nuclear Power Plant units 3, 4. Using KASKAD program package, a preliminary research and design was carried out for the Tianwan Nuclear Power Plant loading TVS-2M fuel assembly from the first cycle to equilibrium cycle. An improved fuel management program was obtained, and the economic analysis of the two fuel management programs with or without TVS-2M assembly was studied. The analysis results show that TVS-2M fuel assembly can improve the economic efficiency of the plant remarkably. (authors)

  16. The competitive forces of the natural gas industry of Mexico; Las fuerzas competitivas de la industria del gas natural de Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Buendia Servin de la Mora, Neil Spar [Facultad de Ingenieria, UNAM (Mexico)

    1997-07-01

    The present paper is intended to identify the structural characteristics of the natural gas national industry, that determines the intensity of the forces in competition. To know the ambient where PEMEX-Gas and Basic Petrochemistry will compete, the distributors and the partnerships formed by national and foreign companies is fundamental, since the forces that affect the market determine the attractiveness of the industry, the gain margins, investments, et cetera. [Spanish] En el presente trabajo se pretende identificar las caracteristicas estructurales de la industria nacional del gas natural, que determinan lo intenso de las fuerzas en competencia. Conocer el ambiente en donde competiran PEMEX-Gas y Petroquimica Basica, las distribuidoras nacionales y los consorcios formados por empresas nacionales y extranjeras es primordial, puesto que las fuerzas que inciden al mercado determinan el atractivo de la industria, los margenes de ganancia, inversiones, etcetera.

  17. Procedimientos para el registro de la trazabilidad de los repuestos aeronáuticos para la Fuerza Aérea Colombiana

    Directory of Open Access Journals (Sweden)

    Carlos Javier Cuervo Lara

    2007-01-01

    Full Text Available La Fuerza Aérea Colombiana, dado su actual desarrollo, debe adquirir o enviar a reparar una mayor cantidad de elementos aeronáuticos tanto dentro del país como fuera del mismo. Para que este procedimiento termine de forma satisfactoria se debe conocer el origen, el estado y el proveedor de estos elementos. Este conocimiento es denominado trazabilidad y aunque la Fuerza Aérea Colombiana lo aplica, especialmente en las adquisiciones y reparaciones en el exterior, las Unidades no tienen un proceso estándar para su aplicación.

  18. Are the Guerrillas Gone?: a historical political economy and social analysis of the rise and demise of the Fuerzas Armadas Revolucionarias Columbianas (FARC), 1964-2010

    OpenAIRE

    Castano, Arturo Herrera; Tarrant, Shane L.

    2009-01-01

    Approved for public release, distribution unlimited This thesis looks at how the Revolutionary Armed Forces of Colombia (FARC) was able to survive and control significant parts of Colombia until relatively recently. It also explains the decline of the FARC as a significant insurgency (and as one of the last, if not the last significant guerrilla organization in the region). While a historical political economy and social analysis of the rise and demise of the Fuerzas Armadas Revolucio...

  19. Are the Guerrillas Gone? A Historical Political Economy and Social Analysis of the Rise and Demise of the Fuerzas Armadas Revolucionarias Colombianas (FARC), 1964-2010

    Science.gov (United States)

    2009-12-01

    directed at the CNP and the Departamento Administrativo de Seguridad (DAS) two separate investigative agencies: Initial reports suggest that CNP...ed.). Bogotá: Ediciones Abejón Mono. Arenas, J., Barco, V., & Fuerzas Armadas Revolucionarias de Colombia. (1990). Vicisitudes del proceso de paz...Organization of American States. (2004, December). II–120 Informe sobre el proceso de Desmobilización en Colombia. Retrieved July 2, 2009, from

  20. EFECTO DEL ENTRENAMIENTO INTEGRADO SOBRE LA MEJORA DE LA FUERZA DE IMPULSIÓN EN UN LANZAMIENTO EN SUSPENSIÓN EN BALONMANO

    OpenAIRE

    P. Padial; I. J. Chirosa; L. J. Chirosa

    2010-01-01

     

    RESUMEN


    Se ha analizado el efecto de dos tipos diferentes de entrenamiento en balonmano, uno que integra carga física y técnica dentro del mismo ejercicio (entrenamiento integrado), y otro que sigue los cánones tradicionales (entrenamiento de fuerza y entrenamiento t&...

  1. Diseño de un sistema de gestión en el manejo de inventarios en la empresa COSSFA S.A. Comisariatos Servicio Social de las Fuerzas Armadas.

    OpenAIRE

    Castellanos Goyes, Verónica Cristina

    2013-01-01

    The preset work shows a management system to manage the company's inventory COSSFA S.A ComisariatosServicio Social de lasFuerzas Armadas. The company was founded in the year 2009 by the Group HOLDINGDINE SA and andactually It is part of the Instituto de Seguridad Social de lasFuerzas Armadas. Showing the management system and the inventory, its importance in business today and how to structure it, in addition to the starting point in devel...

  2. Desarrollo de un modelo generalizado para realimentación de fuerza y torque en cirugía cardiotorácica robótica mínimamente invasiva: determinación de condiciones y restricciones

    Directory of Open Access Journals (Sweden)

    Vera Pérez, IEE., PhD.(c

    2011-07-01

    Conclusiones: Las condiciones relacionadas con la incorporación de un sensor de fuerza y la percepción del cirujano en cuanto al tacto y la fuerza aplicada, resultan ser importantes en procedimientos de MICS robótica y requiere la inclusión de un sistema de control que permita la optimización de procedimientos por telepresencia.

  3. EL APRENDIZAJE DE LOS CONCEPTOS DE FUERZAS INTERMOLECULARES E INTRAMOLECULARES MEDIANTE LA MODELIZACIÓN DIDÁCTICA

    Directory of Open Access Journals (Sweden)

    CHRISTIAN FERNNEY GIRALDO MACÍAS

    2013-07-01

    Full Text Available La modelización está siendo usada para la enseñanza y el aprendizaje en las Ciencias Naturales en diferentes contextos y para atender a diferentes problemáticas. En este caso será utilizada para explorar y analizar la relevancia que puede tener su uso en el aprendizaje de los conceptos Fuerzas Intramoleculares e Intermolecualres, partiendo de la aplicación de una serie de actividades basadas en el Ciclo Didáctico (Jorba y Sanmartí, 1996. Los datos se discuten mediante tres aspectos principales: las ideas previas de los estudiantes, el trabajo con nuevo material (nuevos conceptos, experimentos sencillos y uso de herramientas informáticas y los argumentos finales, mediante el uso de situaciones problemas. Los resultados muestran, como los estudiantes (14 y 16 años de edad evidencian un progreso conceptual al argumentar con mayor claridad las situaciones problema abordadas en el transcurso del trabajo y en la construcción de modelos más cercanos al campo científico.

  4. Reorganización para la seguridad aérea en la Fuerza Aérea Colombiana

    Directory of Open Access Journals (Sweden)

    Edward Jaramillo Sanchez

    2007-01-01

    Full Text Available La investigación estuvo encaminada a la reorganización de la seguridad aérea en la Fuerza Aérea Colombiana, tomando como referencia el Plan Estratégico Institucional 2003-2010 en donde se plantea como objetivo, "Fortalecer los programas de prevención e investigación de accidentes aéreos para evitar la perdida de vidas, de valiosos recursos y el deterioro de la imagen institucional". Con el ánimo de fortalecer esté objetivo, se propone una reorganización de la seguridad que busca el mejoramiento continuo, para obtener resultados favorables ya que los integrantes de la organización saben el papel que desempeñan a nivel grupal dentro de la organización. Lo anterior conduce a un mejor clima organizacional y a lograr mayor eficacia y eficiencia en el desarrollo organizativo, alcanzando los resultados esperados.

  5. Análisis psicométrico del cuestionario de clima laboral de la Fuerza Aérea Colombiana

    Directory of Open Access Journals (Sweden)

    Richard Rosero-Burbano

    2012-01-01

    Full Text Available El objetivo del presente estudio fue proponer un instrumento para medir el clima laboral en la Fuerza Aérea Colombiana. Para ello se diseñó el cuestionario de clima laboral, se evaluaron las características psicométricas y se estableció su utilidad como instrumento de medida. El estudio fue de tipo instrumental, con la participación de 3272 de sus funcionarios, diferenciados por grupos de rango, dependencia, jefatura y bases en el ámbito nacional. Se realizó el análisis de ítems para identificar la potencia discriminativa de cada uno de los ítems, para diferenciar entre quiénes tienen alta percepción de un buen clima laboral y los que no la tienen; la homogeneidad y la consistencia interna. Todas las escalas obtuvieron un alpha mayor a 0,72 y del análisis de cada ítem, se propone una escala de 58 elementos. Se concluye que el cuestionario de clima laboral tiene buena capacidad discriminativa y de homogeneidad.

  6. Reliable Radio Access for Massive Machine-to-Machine (M2M) Communication

    DEFF Research Database (Denmark)

    Madueño, Germán Corrales

    the service requirements can range from massive number of devices to ultra-reliable. This PhD thesis focuses on novel mechanisms to meet these requirements in a variety of wireless systems, from well-established technologies such as cellular networks, to emerging technologies like IEEE 802.11ah. Today...... an overwhelming 89% of the deployed M2M modules are GPRS-based. This motivates us to investigate the potential of GPRS as a dedicated M2M network. We show that by introducing minimal modifications to GPRS operation, a large number of devices can be reliably supported. Surprisingly, even though LTE is seen...... as the preferable solution for M2M, no mechanisms are in place to guarantee reliable M2M access. Contrary to mainstream solutions that focus on preventing overload, we introduce mechanisms to provide reliable M2M service. We also investigate what cellular networks can do about upcoming smart metering traffic...

  7. Evaluation of secure capability-based access control in the M2M local cloud platform

    DEFF Research Database (Denmark)

    Anggorojati, Bayu; Prasad, Neeli R.; Prasad, Ramjee

    2016-01-01

    delegation. Recently, the capability based access control has been considered as method to manage access in the Internet of Things (IoT) or M2M domain. In this paper, the implementation and evaluation of a proposed secure capability based access control in the M2M local cloud platform is presented......Managing access to and protecting resources is one of the important aspect in managing security, especially in a distributed computing system such as Machine-to-Machine (M2M). One such platform known as the M2M local cloud platform, referring to BETaaS architecture [1], which conceptually consists...... of multiple distributed M2M gateways, creating new challenges in the access control. Some existing access control systems lack in scalability and flexibility to manage access from users or entity that belong to different authorization domains, or fails to provide fine grained and flexible access right...

  8. [Identification of C(2)M interacting proteins by yeast two-hybrid screening].

    Science.gov (United States)

    Yue, Shan-shan; Xia, Lai-xin

    2015-11-01

    The synaptonemal complex (SC) is a huge structure which assembles between the homologous chromosomes during meiotic prophase I. Drosophila germ cell-specific nucleoprotein C(2)M clustering at chromosomes can induce SC formation. To further study the molecular function and mechanism of C(2)M in meiosis, we constructed a bait vector for C(2)M and used the yeast two-hybrid system to identify C(2)M interacting proteins. Forty interacting proteins were obtained, including many DNA and histone binding proteins, ATP synthases and transcription factors. Gene silencing assays in Drosophila showed that two genes, wech and Psf1, may delay the disappearance of SC. These results indicate that Wech and Psf1 may form a complex with C(2)M to participate in the formation or stabilization of the SC complex.

  9. Effects of a strength endurance training program on endurance levels Efectos de un programa de entrenamiento de la fuerza-resistencia sobre los niveles de resistencia

    Directory of Open Access Journals (Sweden)

    J. C. Redondo

    2010-09-01

    Full Text Available

    The purpose of the current study was to determine whether a strength endurance training program of lower limbs isolate can increase endurance levels, both aerobic capacity and aerobic power, in order to adapt the strength training for endurance races. 20 phisically active men participated in the study. They were divided into two groups: control group (GC (n=10 and experimental group (GE (n=10. GE carried out a strength endurance training program for ten weeks. Results obtained showed that this type of training regime was useful to improve the performance in an aerobic endurance test. This could be due to an improvement in aerobic capacity, maximal dynamic strength, explosive strength and reactive strength. Moreover, there was a decrease in fat mass without increase in muscle mass.
    Key Words:  Training, strength endurance, aerobic capacity, anthropometry.

     

    El presente estudio pretende comprobar que el trabajo aislado de la fuerza resistencia en miembros inferiores produce una mejora de los niveles de resistencia, en términos tanto de potencia como de capacidad aeróbica, optimizando así el entrenamiento de la fuerza para pruebas de resistencia de media y larga duración. Para ello, veinte sujetos participaron en el estudio, dividiéndose de forma aleatoria en dos grupos: grupo control (GC (n=10 y grupo experimental (GE (n=10 el cual llevó a cabo un entrenamiento de fuerza resistencia extensivo por intervalos, de diez semanas de duración. Los resultados obtenidos muestran que este tipo de entrenamiento es efectivo para mejorar el rendimiento en una prueba de resistencia aeróbica para sujetos físicamente activos, gracias a la mejora de la capacidad aeróbica, de la fuerza máxima dinámica, elástico explosiva y elástico explosivo reactiva y a la disminución de los niveles de grasa

  10. Initial operational experience with Gd-2M+ fuel at Dukovany NPP

    International Nuclear Information System (INIS)

    Borovička, M.; Zýbal, J.

    2015-01-01

    Trend of continuous development of nuclear fuel and fuel cycle can be observed from the very beginning of Dukovany NPP operation. The results of this development are documented on the one hand by extending the length of the cycle and on the other by significant reduction in the number of fresh FA’s which are loaded into reactor cores. As a continuation of this trend introduces Dukovany NPP evolutional change of nuclear fuel from the fuel Gd-2M to the Gd-2M + . (authors) Keywords: Gd-2M + , fuel assembly, operational experience

  11. Measurement of cosmic muon angular distribution and vertical integrated flux by 2 m × 2 m RPC stack at IICHEP-Madurai

    International Nuclear Information System (INIS)

    Pethuraj, S.; Datar, V.M.; Majumder, G.; Ravindran, K.C.; Satyanarayana, B.; Mondal, N.K.

    2017-01-01

    The 50 kton INO-ICAL is a proposed underground high energy physics experiment at Theni, India (9 o 57' N , 77 o 16' E ) to study the neutrino oscillation parameters using atmospheric neutrinos. The Resistive Plate Chamber (RPC) has been chosen as the active detector element for the ICAL detector. An experimental setup consisting of 12 layers of glass RPCs of size 2 m × 2 m has been built at IICHEP, Madurai to study the long term stability and performance of RPCs which are produced on a large scale in Indian industry. In this paper, the studies on the performance of RPCs are presented along with the angular distribution of muons at Madurai (9 o 56' N ,78 o 00' E and Altitude ≈ 160 m from sea level).

  12. Measurement of cosmic muon angular distribution and vertical integrated flux by 2 m × 2 m RPC stack at IICHEP-Madurai

    Science.gov (United States)

    Pethuraj, S.; Datar, V. M.; Majumder, G.; Mondal, N. K.; Ravindran, K. C.; Satyanarayana, B.

    2017-09-01

    The 50 kton INO-ICAL is a proposed underground high energy physics experiment at Theni, India (9o57'N, 77o16'E) to study the neutrino oscillation parameters using atmospheric neutrinos. The Resistive Plate Chamber (RPC) has been chosen as the active detector element for the ICAL detector. An experimental setup consisting of 12 layers of glass RPCs of size 2 m × 2 m has been built at IICHEP, Madurai to study the long term stability and performance of RPCs which are produced on a large scale in Indian industry. In this paper, the studies on the performance of RPCs are presented along with the angular distribution of muons at Madurai (9o56'N,78o00'E and Altitude ≈ 160 m from sea level).

  13. Measurement of cosmic muon angular distribution and vertical integrated flux by 2 m × 2 m RPC stack at IICHEP-Madurai

    Energy Technology Data Exchange (ETDEWEB)

    Pethuraj, S. [Homi Bhabha National Institute, Mumbai-400094, Maharashtra (India); Datar, V.M.; Majumder, G.; Ravindran, K.C.; Satyanarayana, B. [Tata Institute of Fundamental Research, Mumbai-400005, Maharashtra (India); Mondal, N.K., E-mail: s.pethuraj@tifr.res.in, E-mail: vivek.datar@tifr.res.in, E-mail: gobinda@tifr.res.in, E-mail: nabak.mondal@gmail.com, E-mail: kcravi@tifr.res.in, E-mail: bsn@tifr.res.in [Saha Institute of Nuclear Physics, Kolkata-700064, West Bengal (India)

    2017-09-01

    The 50 kton INO-ICAL is a proposed underground high energy physics experiment at Theni, India (9{sup o}57' N , 77{sup o}16' E ) to study the neutrino oscillation parameters using atmospheric neutrinos. The Resistive Plate Chamber (RPC) has been chosen as the active detector element for the ICAL detector. An experimental setup consisting of 12 layers of glass RPCs of size 2 m × 2 m has been built at IICHEP, Madurai to study the long term stability and performance of RPCs which are produced on a large scale in Indian industry. In this paper, the studies on the performance of RPCs are presented along with the angular distribution of muons at Madurai (9{sup o}56' N ,78{sup o}00' E and Altitude ≈ 160 m from sea level).

  14. RESPUESTAS CARDIOVASCULARES AL ENTRENAMIENTO DE FUERZA BAJO OCLUSIÓN VASCULAR [Cardiovascular responses to strength training under occlusive training

    Directory of Open Access Journals (Sweden)

    Sergio Benito Hernández

    2013-11-01

    Full Text Available El entrenamiento de la fuerza bajo oclusión vascular se muestra como una alternativa al entrenamiento de alta intensidad. El presente estudio muestra las respuestas cardiovasculares a este tipo de entrenamiento. 10 sujetos fueron sometidos a dos protocolos de entrenamiento oclusivo diferenciados por el peso levantado, (30% del peso máximo, post30, y 70% del peso máximo, post70. Se registraron los valores de tensión arterial sistólica (TAS, diastólica (TAD y frecuencia cardiaca (FC. Los resultados evidencian disminución significativa en TAS y TAD en el grupo post30 en 7 y 13 mm Hg respectivamente en referencia a los valores basales (p<0.05, resultando un descenso muy significativo en el grupo post70, 14 y 20 mm Hg respectivamente (p<0.005. Los valores de la FC no se vieron alterados por ninguno de los protocolos experimentales (p>0.05. Los efectos de tamaño para todos los grupos resultaron triviales (d<0.25. En conclusión los resultados del presente estudios presentan una tendencia a la reducción de la tensión arterial significativa en TAS y TAD en los protocolos de entrenamiento oclusivo, resultando más notable cuando se aplica la mayor intensidad de entrenamiento. Resultan necesarios más estudios que examinen el comportamiento de los parámetros cardiovasculares tras el entrenamiento de fuerza bajo oclusión vascular.AbstractOcclusive strength training is shown like an alternative to intensive training. Present study shown cardiovascular responses to this training. 10 subjects were subjected to two occlusion training protocols, differentiated by the weight lifted (30 % of maximum weight lifted, post30, and 70 % of maximum weight lifted, post70. The values of arterial systolic tension (TAS, diastolic (TAD and heart rate (FC were recorded. The results showing a significant decline in TAS and TAD after post30 of 7 and 13 mm Hg respectively from basis values (p<0.05, resulting a very significant decline in post70 group, 14 and 20 mm Hg

  15. Perspectivas moleculares y metabólicas de la suplementación con creatina en el entrenamiento de fuerza

    Directory of Open Access Journals (Sweden)

    Diego A. Bonilla

    2015-01-01

    Full Text Available En los últimos años el problema de investigación en el campo de la suplementación deportiva ha cambiado al punto de explicar los mecanismos metabólicos por los cuales la administración de creatina (Cr incrementa el rendimiento en ciertos deportes o simplemente beneficia la adaptación muscular. Esta revisión analiza por primera vez los mecanismos bioquímicos de la ingesta de Cr desde la perspectiva de señalización celular, enfocándose en la mayor biodisponibilidad energética de Cr y optimización de la acción buffer espacial/ temporal que ofrece el sistema Cr/PCr/CK. Además, se examinan aspectos relacionados con el incremento en los procesos de proliferación y diferenciación de células musculares (IGF-I/PI3K/Akt-PKB, SPHK1/ MAPK/p38/MRFs, mTOR, hinchamiento celular, actividad mitótica de células satélite, polimerización de actina y fusión de mioblastos y la inactivación y/o reducción en la expresión de proteínas con funciones ergolíticas (GSK3β, miostatina y regulación de AMPK. De esta manera, se explican el aumento de la masa muscular, la fuerza, la resistencia a la fatiga y el rendimiento en ejercicios de alta intensidad, producidos por la suplementación con monohidrato de Cr, desde un punto de vista metabólico.

  16. Maduración biológica, fuerza y potencia muscular en la brazada de crol

    Directory of Open Access Journals (Sweden)

    Richard R. Casanova Machek

    2017-06-01

    Full Text Available Se trata de una investigación de campo, de tipo correlacional que buscó determinar la relación entre la maduración biológica y la potencia muscular de los miembros superiores en nadadores de categorías menores. Se evaluaron 23 niños(as edades comprendidas entre los 10 y los 13 años. La muestra se caracterizó a través de mediciones antropométricas: estatura, masa corporal, envergadura, composición corporal y superficie corporal, maduración sexual (Tanner, 1975. Se aplicó Test de Wingate (laboratorio y piscina según Dotan y Bar-Or (1983 y Morouco (2009 para miembros superiores para estimar potencia máxima, potencia relativa, potencia promedio, índice de fatiga. Los datos se presentan en medidas de tendencia central y dispersión; se calcularon las diferencias de un factor y se estimaron las correlaciones con la técnica Pearson y Spearman. Los resultados indican que el entrenamiento fuera del agua influyó en el rendimiento dentro del agua. El tamaño de las dimensiones corporales y el número de horas de entrenamiento tiene incidencia sobre la potencia producida por los nadadores, con diferencias notables a partir de los 10 años. Las dimensiones corporales y la mayor frecuencia de entrenamiento semanal generan valores altos de potencia muscular. Se recomienda realizar evaluaciones periódicas de fuerza y potencia, crear y mantener actualizado el perfil antropométrico, aplicar cuestionario de autoevaluación de caracteres de maduración sexual y ajustar los periodos de duración de las horas de entrenamiento, en tanto se incrementen las edades.

  17. Relationship between serum IV-C, β2-m levels and diabetic nephropathy

    International Nuclear Information System (INIS)

    Liu Lu; Zhang Mukun

    2005-01-01

    Objective: To investigate the relationship between the serum type IV collagen (IV-C), β 2 -micro globulin (β 2 -m) levels and diabetic nephropathy. Methods: Serum IV-C, β 2 -m levels were measured with RIA in 30 controls and 86 patients with type 2 diabetics mellitus (35 with diabetic nephropathy and 51 without nephropathy). Results: the serum levels of IV-C and β 2 -m in diabetic patients with nephropathy were significantly higher than those in controls (P 0.05). Conclusion: Serum IV-C and β 2 -m levels increased gradually as the diabetic nephropathy got more severe. They could be a sensitive marker for early diagnosis of development of diabetic nephropathy. (authors)

  18. VT Data - Lidar ASPECT (3.2m) 2004, Chittenden County

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) This metadata applies to the following collection area(s): Chittenden County 2004 3.2m and related ASPECT datasets. This metadata complies with...

  19. Supercritical temperature synthesis of fluorine-doped VO2(M) nanoparticle with improved thermochromic property

    Science.gov (United States)

    Riapanitra, Anung; Asakura, Yusuke; Cao, Wenbin; Noda, Yasuto; Yin, Shu

    2018-06-01

    Fluorine-doped VO2(M) nanoparticles have been successfully synthesized using the hydrothermal method at a supercritical temperature of 490 °C. The pristine VO2(M) has the critical phase transformation temperature of 64 °C. The morphology and homogeneity of the monoclinic structure VO2(M) were adopted by the fluorine-doped system. The obtained particle size of the samples is smaller at the higher concentration of anion doping. The best reduction of critical temperature was achieved by fluorine doping of 0.13% up to 48 °C. The thin films of the fluorine-doped VO2(M) showed pronounced thermochromic property and therefore are suitable for smart window applications.

  20. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    NELSON, R.L.

    2000-05-08

    The CH2M Hill Hanford Group, Inc., Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project

  1. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    International Nuclear Information System (INIS)

    NELSON, R.L.

    2000-01-01

    The CH2M Hill Hanford Group, Inc., Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project

  2. Idaho National Laboratory Technology to Market (T2M) Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Christopher Todd [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bush, Jason William [Idaho National Lab. (INL), Idaho Falls, ID (United States); Gentle, Jake Paul [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hill, Porter Jack [Idaho National Lab. (INL), Idaho Falls, ID (United States); Myers, Kurt Steven [Idaho National Lab. (INL), Idaho Falls, ID (United States); Williams, Christopher Luke [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-01-01

    The objective of this project is to establish a tiered Technology to Market (T2M) curriculum for basic researchers to project leads to measure the effect of technology transfer skills on project success and impact. The plan will train five researchers in basic technology transfer principles where success will be measured by assessing improvements in T2M skills and knowledge after the training is complete, likely using before and after surveys.

  3. EFECTO DE DIFERENTES MÉTODOS DE ENTRENAMIENTO DE CONTRASTE PARA LA MEJORA DE LA FUERZA DE IMPULSIÓN EN UN SALTO VERTICAL

    Directory of Open Access Journals (Sweden)

    P. Padial

    2010-09-01

    Full Text Available

     

    RESUMEN

    La finalidad del presente estudio es conocer el efecto de dos tipos de entrenamiento de contraste de fuerza en los que se combinan cargas ligeras (multisaltos con cargas pesadas (sentadillas al 70% del 1RM sobre las distintas manifestaciones de la fuerza dinámica. La muestra seleccionada se extrajo del Ejercito Español de Tierra, divididos en dos grupos experimentales (n=30: 15 en cada grupo, varones, 22 ± 4 años de edad, sin que existiera para ello grupo control. La razón de este diseño, sin grupo control, es porque está suficientemente comprobado por la literatura científica que el entrenamiento de contraste de fuerza produce ganancias significativas en la altura del salto. La variable independiente manipulada es la forma de combinación de las cargas: en el grupo 1 la combinación de cargas se realiza en la misma serie (grupo de contraste en la serie –CSR- y en el grupo 2 la combinación de cargas se realiza en la misma sesión (grupo de contraste en la sesión – CSS-.Por lo tanto, lo que se trata de determinar es qué método de contraste, de los dos empleados, es más eficaz. Procedimiento: Ambos grupos experimentales entrenaron 3 veces a la semana, durante 8 semanas consecutivas. La intensidad del entrenamiento y la carga fue la misma para los dos grupos. Se realizaron controles, mediante una alfombra de contacto, al inicio y en la 4ª y 8ª semana de la experimentación. Se evaluó la altura de salto siguiendo el protocolo de Bosco: salto sin contramomivimiento (SJ, salto con controamovimiento (CMJ, salto sin contramovimiento con el 50% de peso corporal (SJ50, salto sin contramovimiento con el 100% de peso corporal (SJ100 y la fuerza máxima del tren inferior mediante una repetición máxima -1RM en sentadilla-. Resultados: Tras el correspondiente an

  4. Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.

    Directory of Open Access Journals (Sweden)

    Scott Cukras

    Full Text Available Protein neddylation is involved in a wide variety of cellular processes. Here we show that the DNA damage response is perturbed in cells inactivated with an E2 Nedd8 conjugating enzyme UBE2M, measured by RAD51 foci formation kinetics and cell based DNA repair assays. UBE2M knockdown increases DNA breakages and cellular sensitivity to DNA damaging agents, further suggesting heightened genomic instability and defective DNA repair activity. Investigating the downstream Cullin targets of UBE2M revealed that silencing of Cullin 1, 2, and 4 ligases incurred significant DNA damage. In particular, UBE2M knockdown, or defective neddylation of Cullin 2, leads to a blockade in the G1 to S progression and is associated with delayed S-phase dependent DNA damage response. Cullin 4 inactivation leads to an aberrantly high DNA damage response that is associated with increased DNA breakages and sensitivity of cells to DNA damaging agents, suggesting a DNA repair defect is associated. siRNA interrogation of key Cullin substrates show that CDT1, p21, and Claspin are involved in elevated DNA damage in the UBE2M knockdown cells. Therefore, UBE2M is required to maintain genome integrity by activating multiple Cullin ligases throughout the cell cycle.

  5. Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.

    Science.gov (United States)

    Cukras, Scott; Morffy, Nicholas; Ohn, Takbum; Kee, Younghoon

    2014-01-01

    Protein neddylation is involved in a wide variety of cellular processes. Here we show that the DNA damage response is perturbed in cells inactivated with an E2 Nedd8 conjugating enzyme UBE2M, measured by RAD51 foci formation kinetics and cell based DNA repair assays. UBE2M knockdown increases DNA breakages and cellular sensitivity to DNA damaging agents, further suggesting heightened genomic instability and defective DNA repair activity. Investigating the downstream Cullin targets of UBE2M revealed that silencing of Cullin 1, 2, and 4 ligases incurred significant DNA damage. In particular, UBE2M knockdown, or defective neddylation of Cullin 2, leads to a blockade in the G1 to S progression and is associated with delayed S-phase dependent DNA damage response. Cullin 4 inactivation leads to an aberrantly high DNA damage response that is associated with increased DNA breakages and sensitivity of cells to DNA damaging agents, suggesting a DNA repair defect is associated. siRNA interrogation of key Cullin substrates show that CDT1, p21, and Claspin are involved in elevated DNA damage in the UBE2M knockdown cells. Therefore, UBE2M is required to maintain genome integrity by activating multiple Cullin ligases throughout the cell cycle.

  6. Evaluación de la asimetría y el déficit bilateral de los extensores de la rodilla en diferentes manifestaciones de la fuerza = Asymetry and bilateral deficit's assessment of knee extensors in the different manifestations of strength

    OpenAIRE

    Pérez-Landaluce González, Juan

    2016-01-01

    El objetivo esencial de este estudio fue, evaluar y cuantificar el déficit bilateral y la asimetría, de la masa muscular encargada de la extensión de la rodilla, en tres manifestaciones de la fuerza. Para dar respuesta a la hipótesis planteada, se llevaron a cabo varias pruebas, una para cada manifestación de la fuerza estudiada: fuerza isométrica máxima, fuerza dinámica máxima y potencia. Los resultados obtenidos concluyeron que no había diferencias significativas para la asimetría, y en cua...

  7. UCP2 mRNA expression is dependent on glucose metabolism in pancreatic islets

    International Nuclear Information System (INIS)

    Dalgaard, Louise T.

    2012-01-01

    Highlights: ► UCP2 mRNA levels are decreased in islets of Langerhans from glucokinase deficient mice. ► UCP2 mRNA up-regulation by glucose is dependent on glucokinase. ► Absence of UCP2 increases GSIS of glucokinase heterozygous pancreatic islets. ► This may protect glucokinase deficient mice from hyperglycemic damages. -- Abstract: Uncoupling Protein 2 (UCP2) is expressed in the pancreatic β-cell, where it partially uncouples the mitochondrial proton gradient, decreasing both ATP-production and glucose-stimulated insulin secretion (GSIS). Increased glucose levels up-regulate UCP2 mRNA and protein levels, but the mechanism for UCP2 up-regulation in response to increased glucose is unknown. The aim was to examine the effects of glucokinase (GK) deficiency on UCP2 mRNA levels and to characterize the interaction between UCP2 and GK with regard to glucose-stimulated insulin secretion in pancreatic islets. UCP2 mRNA expression was reduced in GK+/− islets and GK heterozygosity prevented glucose-induced up-regulation of islet UCP2 mRNA. In contrast to UCP2 protein function UCP2 mRNA regulation was not dependent on superoxide generation, but rather on products of glucose metabolism, because MnTBAP, a superoxide dismutase mimetic, did not prevent the glucose-induced up-regulation of UCP2. Glucose-stimulated insulin secretion was increased in UCP2−/− and GK+/− islets compared with GK+/− islets and UCP2 deficiency improved glucose tolerance of GK+/− mice. Accordingly, UCP2 deficiency increased ATP-levels of GK+/− mice. Thus, the compensatory down-regulation of UCP2 is involved in preserving the insulin secretory capacity of GK mutant mice and might also be implicated in limiting disease progression in MODY2 patients.

  8. Estudio del rendimiento del torneado de alta velocidad utilizando el coeficiente de dimensión volumétrica de la fuerza de corte resultante

    Directory of Open Access Journals (Sweden)

    Hernández-González, L. W.

    2013-08-01

    Full Text Available This work deals with the experimental study of the resultant cutting force evolution of two coating carbide and a cermet inserts, during the dry turning of AISI 1045 steel with 400, 500 and 600 m/min cutting speeds. A new criterion for machinability study, the coefficient of volumetric dimension of cutting force, it is introduced. The investigation showed a better performance of cermet for moderate and intermediate cutting speeds, while at high cutting speed and final machining time, the three layers coated carbide achieved the best result. The factorial analysis of variance demonstrated a significant effect of machining time on the coefficient of volumetric dimension of resultant cutting force, while the material insert factor and their interaction, for intermediate cutting speed was just significant.En este trabajo se aborda el estudio experimental de la evolución de la fuerza de corte resultante de dos insertos de carburo recubierto y un cermet, durante el torneado en seco del acero AISI 1045 con velocidades de corte de 400, 500 y 600 m/min . Se introduce, además, un nuevo criterio para el estudio del rendimiento de las operaciones de mecanizado: el coeficiente de dimensión volumétrica de la fuerza de corte. La investigación mostró un mejor rendimiento del cermet para la velocidad de corte moderada e intermedia, mientras que para la alta velocidad de corte y tiempo final de mecanizado, el mejor resultado fue para el carburo recubierto con tres capas. El análisis de varianza factorial demostró un efecto significativo del tiempo de mecanizado en el coeficiente de dimensión volumétrica de la fuerza de corte resultante, mientras que la variable material del inserto y su interacción, fue solo significativa para la velocidad de corte intermedia.

  9. Análisis del potencial competitivo del bioetanol en colombia: un enfoque desde las 5 fuerzas competitivas de michael porter

    OpenAIRE

    RAMIREZ VELASQUEZ, ALEJANDRO; MONTOYA R., IVÁN ALONSO; MONTOYA RESTREPO, ALEXANDRA

    2012-01-01

    La búsqueda de alternativas de producción y consumo energético requiere una mirada hacia la industria de los combustibles biológicos como el bioetanol que, como alternativa energética, permita superar los inconvenientes generados por los métodos tradicionales de producción y consumo, en especial en los temas políticos, ambientales y sociales y generar ventajas competitivas frente a otras fuentes primarias de energía. En el presente documento,a partir del modelo de las cinco (5) Fuerzas de Mic...

  10. GOBERNANZA PARA LA GOBERNABILIDAD. LA CONSTRUCCIÓN DE “FUERZA CIVIL”, LA NUEVA POLICÍA DE NUEVO LEÓN

    OpenAIRE

    Héctor Eduardo Mendoza Márquez; Juan Carlos Montero Bagatella

    2015-01-01

    El siguiente trabajo expone el proceso de construcción de la nueva policía estatal de Nuevo León: Fuerza Civil. La importancia de la institución, radica en que ha sido reconocida como un ejemplo a nivel nacional y en la actualidad ya es replicada en varios estados de la república. En particular, el artículo destaca la formación de la Alianza por la Seguridad como un elemento fundamental para el diseño e implementación de la política de seguridad pública, en un ejercicio de gobernanza du...

  11. Ganando fuerza para el ejercicio de nuestra ciudadanía: Guía dirigida a mujeres y personas trans que realizan trabajo sexual

    OpenAIRE

    Vargas Valente, María Elizabeth

    2009-01-01

    A partir de 2005 el UNFPA ha asumido la responsabilidad de apoyar los esfuerzos de prevención y acceso a servicios de salud de las poblaciones más vulnerables frente a la epidemia del VIH, particularmente las trabajadoras sexuales, especialmente en países como el Perú donde la epidemia está concentrada en algunos subgrupos de la población. Es por ello que hoy nos complace presentar la Guía de Capacitación Ganando Fuerza para el Ejercicio de Nuestra Ciudadanía, dirigida a mujeres y personas tr...

  12. La Cooperativa de Luz y Fuerza de Río Tercero: una institución al servicio de su comunidad, 1933- 1953

    Directory of Open Access Journals (Sweden)

    María Elena Rodríguez

    2006-01-01

    Full Text Available En nuestro país, las cooperativas eléctricas surgieron a partir de la década de 1920 como reacción popular frente a las elevadas tarifas y al deficiente servicio proporcionado por las empresas de capital extranjero que tenían a su cargo la generación y la distribución de energía. La provincia de Córdoba no fue ajena a este fenómeno, en este artículo nos proponemos mostrar las circunstancias en que surgió la Cooperativa de Luz y Fuerza de Río Tercero en 1933, la que a diferencia de otras de la provincia de Córdoba no generaba la energía que distribuía sino que la compraba a la usina hidráulica del dique Río Tercero, y al mismo tiempo resaltar también su evolución y las repercusiones de su gestión durante las dos primeras décadas de vida en las que prestó el servicio de energía eléctrica y comenzó con las gestiones encaminadas a concretar la provisión de agua corriente a la población de Río Tercero, convirtiéndose en la Cooperativa de Luz y Fuerza y Agua Potable de Río Tercero Limitada inaugurando ese servicio en 1953.In our country, the electric cooperatives appeared in the 1920's decade as a popular reaction against the high bills and deficient service given by the enterprices of abroad capital that were in charge of energy generation and distribution.The Córdoba's province was not indifferent to this phenomenon, in this article we have the purpose to show the circumstances in which have place the Cooperativa de Luz y Fuerza de Río Tercero in 1933, this was different from the others in Córdoba's province because it did not generate the energy that distributed but bought it to the hydraulic usine of Rio Tercero's dock, and at the same time we want to rebound its evolution and the repercussions of its work during its first two decades of life in which it supplied of electric energy and began to negotiate to bring running water to the population of Rio Tercero, inaugurating that service in 1953 and becoming

  13. El plan de desarrollo de la Fuerza Armada Nacional Bolivariana, "Plan Sucre 2007-2013”, y las implicaciones para la seguridad nacional de Colombia

    OpenAIRE

    Hurtado, Camilo; Cadena Afanador, Walter René

    2015-01-01

    Este trabajo de investigación analiza, desde la cosmovisión neorrealista de las Relaciones Internacionales, los alcances del Plan de Desarrollo de la Fuerza Armada Nacional Bolivariana, Plan Sucre, y las repercusiones que su consolidación tendrá para la seguridad nacional de Colombia. Inicialmente se plantea un marco teórico y conceptual, lo cual permite avanzar al segundo capítulo el cual tiene como propósito fundamental describir en qué consiste el Plan Sucre. El capítulo tres analiza los a...

  14. El entrenamiento de la fuerza para la mejora del rendimiento físico-deportivo y la prevención de lesiones en el fútbol

    OpenAIRE

    Raya González, Javier

    2017-01-01

    Programa de Doctorado en Ciencias de la Actividad Física y del Deporte Esta Tesis Doctoral versa sobre el fútbol, respecto a sus características y la aplicación de un entrenamiento de fuerza con sobrecarga excéntrica que incrementa en pocas semanas la potencia del tren inferior, y produce otras mejoras en variables relacionadas con el rendimiento en el fútbol. También se estudian los efectos de 2 programas de entrenamiento neuromuscular con diferente orientación, para conocer la mejora de ...

  15. Propuesta de planificación y periodización de la fuerza en el judo en deportistas de alto nivel

    OpenAIRE

    Sánchez Delgado, Sergio

    2014-01-01

    En el presente trabajo se plantea una planificación de la fuerza alternativa para el judo en el alto nivel. Para ello, se han propuesto sesiones de entrenamiento específicas en tatami, así como específicas en gimnasio, así como una distribución de dichas sesiones durante las semanas de trabajo. Todo esto, en diferentes momentos de la temporada, los cuales hemos llamado periodos, que perseguirán unos objetivos concretos de una manera concreta y secuencializada.

  16. Relaci??n entre la masa muscular, la densidad mineral ??sea, la fuerza muscular, la aptitud funcional y la calidad muscular en personas mayores

    OpenAIRE

    Pati??o Villada, Fredy Alonso

    2015-01-01

    294 p. La tesis pretende determinar la frecuencia de la sarcopenia y osteporosis , problemas que afectan a la salud de las personas mayores, y analizar la relaci??n entre la masa muscular, la densidad mineral ??sea (DMO), la fuerza muscular, la aptitud funcional y la calidad muscular (CM). La muestra estudiada fue la formada por un grupo de 83 hombres y 175 mujeres mayores de Le??n (Espa??a). El estudio transversal eval??a ??ndices de masa grasa y densidad mineral ??sea y niveles d...

  17. The challenges of M2M massive access in wireless cellular networks

    Directory of Open Access Journals (Sweden)

    Andrea Biral

    2015-02-01

    Full Text Available The next generation of communication systems, which is commonly referred to as 5G, is expected to support, besides the traditional voice and data services, new communication paradigms, such as Internet of Things (IoT and Machine-to-Machine (M2M services, which involve communication between Machine-Type Devices (MTDs in a fully automated fashion, thus, without or with minimal human intervention. Although the general requirements of 5G systems are progressively taking shape, the technological issues raised by such a vision are still partially unclear. Nonetheless, general consensus has been reached upon some specific challenges, such as the need for 5G wireless access networks to support massive access by MTDs, as a consequence of the proliferation of M2M services. In this paper, we describe the main challenges raised by the M2M vision, focusing in particular on the problems related to the support of massive MTD access in current cellular communication systems. Then we analyze the most common approaches proposed in the literature to enable the coexistence of conventional and M2M services in the current and next generation of cellular wireless systems. We finally conclude by pointing out the research challenges that require further investigation in order to provide full support to the M2M paradigm.

  18. Aggregation and Trunking of M2M Traffic via D2D Connections

    DEFF Research Database (Denmark)

    Rigazzi, Giovanni; Kiilerich Pratas, Nuno; Popovski, Petar

    2015-01-01

    Machine-to-Machine (M2M) communications is one of the key enablers of the Internet of Things (IoT). Billions of devices are expected to be deployed in the near future for novel M2M applications demanding ubiquitous access and global connectivity. In order to cope with the massive number of machines......, there is a need for new techniques to coordinate the access and allocate the resources. Although the majority of the proposed solutions are focused on the adaptation of the traditional cellular networks to the M2M traffic patterns, novel approaches based on the direct communication among nearby devices may...... represent an effective way to avoid access congestion and cell overload. In this paper, we propose a new strategy inspired by the classical Trunked Radio Systems (TRS), exploiting the Device-to-Device (D2D) connectivity between cellular users and Machine-Type Devices (MTDs). The aggregation of the locally...

  19. Mitofusin 1 is degraded at G2/M phase through ubiquitylation by MARCH5

    Directory of Open Access Journals (Sweden)

    Park Yong-Yea

    2012-12-01

    Full Text Available Abstract Background Mitochondria exhibit a dynamic morphology in cells and their biogenesis and function are integrated with the nuclear cell cycle. In mitotic cells, the filamentous network structure of mitochondria takes on a fragmented form. To date, however, whether mitochondrial fusion activity is regulated in mitosis has yet to be elucidated. Findings Here, we report that mitochondria were found to be fragmented in G2 phase prior to mitotic entry. Mitofusin 1 (Mfn1, a mitochondrial fusion protein, interacted with cyclin B1, and their interactions became stronger in G2/M phase. In addition, MARCH5, a mitochondrial E3 ubiquitin ligase, reduced Mfn1 levels and the MARCH5-mediated Mfn1 ubiquitylation were enhanced in G2/M phase. Conclusions Mfn1 is degraded through the MARCH5-mediated ubiquitylation in G2/M phase and the cell cycle-dependent degradation of Mfn1 could be facilitated by interaction with cyclin B1/Cdk1 complexes.

  20. Estimation of power feedback parameters of pulse reactor IBR-2M on transients

    International Nuclear Information System (INIS)

    Pepyolyshev, Yu.N.; Popov, A.K.

    2013-01-01

    Parameters of the IBR-2M reactor power feedback (PFB) on a model of the reactor dynamics by mathematical treatment of two registered transients are estimated. Frequency characteristics and the pulse transient characteristics corresponding to these PFB parameters are calculated. PFB parameters received thus can be considered as their express tentative estimation as real measurements in this case occupy no more than 30 minutes. Total PFB is negative at 1 and 2 MW. At the received estimations of PFB parameters in a self-regulation mode it is possible to consider the stability margins of the IBR-2M reactor satisfactory

  1. Development of high-spatial resolution TV Thomson scattering system for JFT-2M

    International Nuclear Information System (INIS)

    Yamauchi, Toshihiko; Shiina, Tomio; Kozawa, Teruo; Ishige, Youichi.

    1996-01-01

    The JFT-2M TV Thomson scattering system (TVTS) with high spatial resolution was completed in the cooperation of the fusion research and development for the DOE-JAERI collaborative program, and has been operated for 3 years. The system is composed of six subsystems; vacuum components, optics, detector, control and data acquisition, software and laser subsystems. TVTS was totally tested in the JFT-2M tokamak and the electron temperature and density profiles are measured with good reproducibility, and the increase of electron temperature by increasing toroidal magnetic field is also measured with TVTS. (author)

  2. Hollow density profile on electron cyclotron resonance heating JFT-2M plasma

    International Nuclear Information System (INIS)

    Yamauchi, Toshihiko; Hoshino, Katsumichi; Kawashima, Hisato; Ogawa, Toshihide; Kawakami, Tomohide; Shiina, Tomio; Ishige, Youichi

    1998-01-01

    The first hollow electron density profile in the central region on the JAERI Fusion Torus-2M (JFT-2M) is measured during electron cyclotron resonance heating (ECRH) with a TV Thomson scattering system (TVTS). The peripheral region is not hollow but is accumulated due to pump-out from the central region. The hollowness increases with time but is saturated at ∼40 ms and maintains a constant hollow ratio. The hollowness is strongly related to the steep temperature gradient of the heated zone. (author)

  3. Progesterone receptor blockade in human breast cancer cells decreases cell cycle progression through G2/M by repressing G2/M genes.

    Science.gov (United States)

    Clare, Susan E; Gupta, Akash; Choi, MiRan; Ranjan, Manish; Lee, Oukseub; Wang, Jun; Ivancic, David Z; Kim, J Julie; Khan, Seema A

    2016-05-23

    The synthesis of specific, potent progesterone antagonists adds potential agents to the breast cancer prevention and treatment armamentarium. The identification of individuals who will benefit from these agents will be a critical factor for their clinical success. We utilized telapristone acetate (TPA; CDB-4124) to understand the effects of progesterone receptor (PR) blockade on proliferation, apoptosis, promoter binding, cell cycle progression, and gene expression. We then identified a set of genes that overlap with human breast luteal-phase expressed genes and signify progesterone activity in both normal breast cells and breast cancer cell lines. TPA administration to T47D cells results in a 30 % decrease in cell number at 24 h, which is maintained over 72 h only in the presence of estradiol. Blockade of progesterone signaling by TPA for 24 h results in fewer cells in G2/M, attributable to decreased expression of genes that facilitate the G2/M transition. Gene expression data suggest that TPA affects several mechanisms that progesterone utilizes to control gene expression, including specific post-translational modifications, and nucleosomal organization and higher order chromatin structure, which regulate access of PR to its DNA binding sites. By comparing genes induced by the progestin R5020 in T47D cells with those increased in the luteal-phase normal breast, we have identified a set of genes that predict functional progesterone signaling in tissue. These data will facilitate an understanding of the ways in which drugs such as TPA may be utilized for the prevention, and possibly the therapy, of human breast cancer.

  4. Progesterone receptor blockade in human breast cancer cells decreases cell cycle progression through G2/M by repressing G2/M genes

    International Nuclear Information System (INIS)

    Clare, Susan E.; Gupta, Akash; Choi, MiRan; Ranjan, Manish; Lee, Oukseub; Wang, Jun; Ivancic, David Z.; Kim, J. Julie; Khan, Seema A.

    2016-01-01

    The synthesis of specific, potent progesterone antagonists adds potential agents to the breast cancer prevention and treatment armamentarium. The identification of individuals who will benefit from these agents will be a critical factor for their clinical success. We utilized telapristone acetate (TPA; CDB-4124) to understand the effects of progesterone receptor (PR) blockade on proliferation, apoptosis, promoter binding, cell cycle progression, and gene expression. We then identified a set of genes that overlap with human breast luteal-phase expressed genes and signify progesterone activity in both normal breast cells and breast cancer cell lines. TPA administration to T47D cells results in a 30 % decrease in cell number at 24 h, which is maintained over 72 h only in the presence of estradiol. Blockade of progesterone signaling by TPA for 24 h results in fewer cells in G2/M, attributable to decreased expression of genes that facilitate the G2/M transition. Gene expression data suggest that TPA affects several mechanisms that progesterone utilizes to control gene expression, including specific post-translational modifications, and nucleosomal organization and higher order chromatin structure, which regulate access of PR to its DNA binding sites. By comparing genes induced by the progestin R5020 in T47D cells with those increased in the luteal-phase normal breast, we have identified a set of genes that predict functional progesterone signaling in tissue. These data will facilitate an understanding of the ways in which drugs such as TPA may be utilized for the prevention, and possibly the therapy, of human breast cancer. The online version of this article (doi:10.1186/s12885-016-2355-5) contains supplementary material, which is available to authorized users

  5. Efecto sobre la mejora y retención de la fuerza de un programa de entrenamiento de fuerza con cargas concentradas en sujetos no entrenados. Effect on the strength improvement and retention during a training program with concentrated loads in non trained subjects.

    Directory of Open Access Journals (Sweden)

    Navarro Valdivielso, Fernando

    2007-04-01

    Full Text Available ResumenEn este estudio se ha analizado la mejora y retención de la fuerza en 34 sujetos no entrenados, distribuidos de forma aleatoria en un grupo experimental (GE (n=17 que efectuó un programa de entrenamiento para la mejora de la misma de 9 semanas de duración, realizando 4 sesiones consecutivas de entrenamiento semanal, y un grupo control (GC (n=17 que no llevó a cabo ningún entrenamiento. Se tomaron mediciones del peso máximo elevado en 1RM, la fuerza máxima, y la fuerza media total, con el sistema de medición de fuerzas dinámicas Isocontrol 3.6, en el ejercicio de squat (SQ, antes (PRE-, en la mitad (MED- y al final del tratamiento (POST 1, así como tras 1 (POST 2 y 2 meses (POST 3 de la finalización mismo. En el GE, las ganancias de fuerza fueron altamente significativas (pAbstractIn this study has analyzed the improvement and retention of strength in 34 nontrained subjects, randomized in an experimental group(GE (n=17 who realized a strength training program during 9 weeks, making 4 consecutive sessions of weekly training, and a control group (GC (n=17 who did not realized any training. The 1 repetition maximum (1RM, maximum strength, total mean strength, were measured with ISOCONTROL 3.6. device in squat (SQ. The measured were done before (PRE-, in the middle (MED-, at the end of the treatment (POST 1, as well as after 1 and 2 months of the conclusion of the same one. In the experimental group, the strength gains were highly significant as much in the middle (19%, as at the end of the training program (35%, and even after 2 months of the conclusion of the same one (40%. In the GC significant changes did not take place. In conclusion, after 9 weeks of strength training, can be obtained improvements of same highly significant using concentrated loads in nontrained subjects, and they are possible to be continued reaching greater gains during at least other 8 weeks after more finalized the training.

  6. La fuerza de los lazos: una exploración teórica y empírica de sus múltiples significados

    Directory of Open Access Journals (Sweden)

    Irene Cruz Gómez

    2013-01-01

    Full Text Available La fuerza del vínculo es una de las características recurrentemente estudiadas en las redes personales. Es un dato aparentemente sencillo de generar, con una potencial capacidad predictiva sobre los intercambios dentro de la relación y de la posición del contacto dentro de la red. Sin embargo, la gran diversidad de indicadores que se emplean en la literatura para medir esta fuerza del vínculo da fe de la vaguedad en la definición del concepto y las consecuentes dificultades para operativizarlo, dando lugar a resultados ambivalentes en su observación empírica. Con este trabajo de revisión teórica, metodológica y empírica se pre- tende ofrecer una base sobre la cual contribuir a la delimitación del concepto. Se propone una dimensionalización teórica de la noción, distinguiendo sus aspectos expresivos, sociales y estructurales, y a continuación se compara el comportamiento de diversos indicadores de las distintas dimensiones empleando una muestra de 441 redes personales y 13.230 relaciones provenientes de una encuesta realizada en Cataluña entre 2009 y 2010.

  7. La fuerza de los vínculos débiles en la inserción laboral de los migrantes nicaragüenses

    Directory of Open Access Journals (Sweden)

    Borge, Dalia

    2005-07-01

    Full Text Available Se trata de un artículo que pretende dar a conocer la fuerza que tienen los vínculos débiles simulados como vínculos fuertes en la red social de migrantes trabajadores de nicaragüenses en Costa Rica. Para el análisis se observa el fenómeno de la migración desde el capital social de Bourdieu (2001 y Coleman (1988, así como de los análisis realizados por Granovetter (2000 en cuanto a la fuerza de los vínculos débiles. Mediante la realización de treinta entrevistas a los integrantes de una red que se denominó como agrícola, se logra observar que la recomendación que un actor de la red hace para que un tercero ingrese a un trabajo remunerado, se hace simulando que se conoce y que se da fe sobre las habilidades del futuro trabajador. Este simulacro del vínculo débil como fuerte, es lo que finalmente permite el éxito en la inserción laboral del migrante.

  8. ANÁLISIS COMPARATIVO DE LOS EFECTOS AGUDOS DE SESIONES DE ENTRENAMIENTO DE FUERZA CON CARGAS DEL 90 Y 30% 1 RM.

    Directory of Open Access Journals (Sweden)

    Jorge Dopico Calvo

    2010-10-01

    Full Text Available En una medición inicial (Pretest se obtuvo la 1RM de 23 sujetos masculinos en el ejercicio press banca, así como la potencia y fuerza media aplicada al 90 y 30% de 1RM (PMED90, FMED90, PMED30, FMED 30. Posteriormente 11 sujetos (Gr90 llevaron a cabo 2 sesiones de entrenamiento con cargas del 90%, mientras los 12 sujetos restantes (Gr30 lo hacían con cargas del 30%. Inmediatamente finalizada cada una de las sesiones se valoraba nuevamente PMED90, FMED90, PMED30, FMED30. Una semana después de la finalización de los entrenamientos se efectuó un Postest. Los resultados mostraron una mejora estadísticamente significativa del rendimiento de Gr30 al final de cada una de las sesiones de entrenamiento, respecto a Pretest y Postest, con el 90% de 1RM, mientras que Gr90 obtuvo mejoras significativas con el 30% respecto a Pretest, pero no respecto a Postest.
    PALABRAS CLAVE: fuerza, potencia, medición, efecto agudo.

  9. APLICACIÓN DE LA PLATAFORMA DE FUERZAS COMO RECURSO PARA LA OPTIMIZACIÓN DE LA TÉCNICA EN ACROSPORT

    Directory of Open Access Journals (Sweden)

    A. Bote García

    2010-10-01

    Full Text Available

     

    El objetivo principal del presente estudio ha sido conocer la aplicación de fuerzas en el suelodel portor en un lanzamiento en acrosport, con el fin de determinar el nivel de rendimiento.Para ello, se plantearon dos situaciones experimentales que permitieron el estudio cinéticode la acción del lanzador. En la primera, una pareja de acrosport, realizó 30 repeticiones deun gesto de lanzamiento. La variabilidad de los resultados encontrados en la aplicación defuerza llevo a plantear otra situación experimental únicamente con el portor con el fin dedeterminar si dicha variabilidad se podía explicar por su actuación. Los resultados hanposibilitado describir el patrón del lanzamiento en términos mecánicos, y demostrar laeficacia de los estudios biomecánicos en la aplicación de corrección de errores técnicos.

    PALABRAS CLAVE: Acrosport, plataforma de fuerza, variabilidad en la ejecución

  10. Energetic particle physics in JT-60U and JFT-2M

    Energy Technology Data Exchange (ETDEWEB)

    Shinohara, K [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki, 311-0193 (Japan); Takechi, M [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki, 311-0193 (Japan); Ishikawa, M [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki, 311-0193 (Japan); Kusama, Y [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki, 311-0193 (Japan); Tsuzuki, K [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki, 311-0193 (Japan); Urata, K [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki, 311-0193 (Japan); Kawashima, H [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki, 311-0193 (Japan); Tobita, K [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki, 311-0193 (Japan); Fukuyama, A [Department of Nuclear Engineering, Kyoto University, 606-8501, (Japan); Cheng, C Z [Princeton Plasma Physics Laboratory, PO Box 451, Princeton, NJ 08543 (United States); Darrow, D S [Princeton Plasma Physics Laboratory, PO Box 451, Princeton, NJ 08543 (United States); Kramer, G J [Princeton Plasma Physics Laboratory, PO Box 451, Princeton, NJ 08543 (United States); Gorelenkov, N N [Princeton Plasma Physics Laboratory, PO Box 451, Princeton, NJ 08543 (United States); Nazikian, R [Princeton Plasma Physics Laboratory, PO Box 451, Princeton, NJ 08543 (United States); Todo, Y [National Institute for Fusion Science, Oroshi-cho, Toki, Gifu, 509-5292, (Japan); Miura, Y [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki, 311-0193 (Japan); Ozeki, T [Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki, 311-0193 (Japan)

    2004-07-01

    Recent energetic particle physics research in JT-60U and JFT-2M is reported. Alfven eigenmodes (AEs) are investigated in reversed-shear (RS) plasmas in JT-60U where frequency sweeping (FS) modes are observed to follow the q-profile evolution. The RS-induced AE model can explain the FS of the modes within the context of an evolving q-profile. Enhanced energetic ion transport is also investigated with the appearance of modes in the toroidicity-induced AE range of frequency in JT-60U using a multi-channel neutron profile monitor and in JFT-2M using a lost ion probe. Additionally, the ripple loss in the complex toroidal field ripple due to ferritic steel inserts in JFT-2M is shown and compared with model analysis. The simulation code developed to predict ripple loss in JFT-2M will be of use in estimating the heat flux in the complex ripple field of a future device such as ITER.

  11. Temperature and Pressure Dependence of the Reaction S plus CS (+M) -> CS2 (+M)

    DEFF Research Database (Denmark)

    Glarborg, Peter; Marshall, Paul; Troe, Juergen

    2015-01-01

    Experimental data for the unimolecular decomposition of CS2 from the literature are analyzed by unimolecular rate theory with the goal of obtaining rate constants for the reverse reaction S + CS (+M) -> CS2 (+M) over wide temperature and pressure ranges. The results constitute an important input...

  12. Massive M2M Access with Reliability Guarantees in LTE Systems

    DEFF Research Database (Denmark)

    Madueño, Germán Corrales; Kiilerich Pratas, Nuno; Stefanovic, Cedomir

    2015-01-01

    Machine-to-Machine (M2M) communications are one of the major drivers of the cellular network evolution towards 5G systems. One of the key challenges is on how to provide reliability guarantees to each accessing device in a situation in which there is a massive number of almost-simultaneous arriva...

  13. Almost optimal distributed M2M multicasting in wireless mesh networks

    DEFF Research Database (Denmark)

    Xin, Qin; Manne, Fredrik; Zhang, Yan

    2012-01-01

    Wireless Mesh Networking (WMN) is an emerging communication paradigm to enable resilient, cost-efficient and reliable services for the future-generation wireless networks. In this paper, we study the problem of multipoint-to- multipoint (M2M) multicasting in a WMN which aims to use the minimum nu...

  14. NFBD1/MDC1 participates in the regulation of G2/M transition in mammalian cells

    International Nuclear Information System (INIS)

    Bu, Youquan; Suenaga, Yusuke; Okoshi, Rintaro; Sang, Meixiang; Kubo, Natsumi; Song, Fangzhou; Nakagawara, Akira; Ozaki, Toshinori

    2010-01-01

    NFBD1/MDC1 is a large nuclear protein involved in the early cellular response to DNA damage. Upon DNA damage, NFBD1 has an ability to facilitate the efficient DNA repair. In the present study, we have found that, in addition to DNA damage response, NFBD1 plays a critical role in the regulation of G2/M transition. Expression study using synchronized HeLa cells demonstrated that, like the mitotic kinase Plk1, NFBD1 expression level is maximal in G2/M-phase of the cell cycle. siRNA-mediated knockdown of NFBD1 resulted in G2/M arrest as well as simultaneous apoptosis in association with a significant increase in the amounts of γH2AX and pro-apoptotic p73. Since a remarkable down-regulation of mitotic phospho-histone H3 was detectable in NFBD1-knocked down cells, it is likely that knocking down of NFBD1 inhibits G2/M transition. Taken together, our present findings suggest that NFBD1 has a pivotal role in the regulation of proper mitotic entry.

  15. Development of bucket ion source for JFT-2M neutral beam injector

    International Nuclear Information System (INIS)

    Shibata, Takatoshi; Kazawa, Minoru; Yokoyama, Kenji; Shibuya, Toshihiro; Honda, Atsushi; Shiina, Tomio

    1987-02-01

    Detailed description is given of a new Bucket Ion Source for NBI heating experiments on JFT-2M. The source is designed to achieve the high proton ratio (∼ 80 %) as well as high power. Results of the performance test is also given. (author)

  16. A Survey on M2M Systems for mHealth: A Wireless Communications Perspective

    Directory of Open Access Journals (Sweden)

    Elli Kartsakli

    2014-09-01

    Full Text Available In the new era of connectivity, marked by the explosive number of wireless electronic devices and the need for smart and pervasive applications, Machine-to-Machine (M2M communications are an emerging technology that enables the seamless device interconnection without the need of human interaction. The use of M2M technology can bring to life a wide range of mHealth applications, with considerable benefits for both patients and healthcare providers. Many technological challenges have to be met, however, to ensure the widespread adoption of mHealth solutions in the future. In this context, we aim to provide a comprehensive survey on M2M systems for mHealth applications from a wireless communication perspective. An end-to-end holistic approach is adopted, focusing on different communication aspects of the M2M architecture. Hence, we first provide a systematic review ofWireless Body Area Networks (WBANs, which constitute the enabling technology at the patient’s side, and then discuss end-to-end solutions that involve the design and implementation of practical mHealth applications. We close the survey by identifying challenges and open research issues, thus paving the way for future research opportunities.

  17. Electrodialytic remediation of CCA-treated waste wood in a 2 m3 pilot plant

    DEFF Research Database (Denmark)

    Christensen, Iben Vernegren; Pedersen, Anne Juul; Ottosen, Lisbeth M.

    2006-01-01

    Waste wood that has been treated with chromated-copper-arsenate (CCA) poses a potential environmental problem due to the content of copper, chromium and arsenic. A pilot plant for electrodialytic remediation of up to 2 m3 wood has been designed and tested and the results are presented here. Sever...

  18. The Discharge Design of HL-2M with the Tokamak Simulation Code (TSC)

    International Nuclear Information System (INIS)

    Yudong Pan; Jardin, S.C.; Kes, C.

    2007-01-01

    We present results on the discharge design of the HL-2M tokamak, which is to be an upgrade to the existing HL-2A tokamak. We present simulation results for complete 5-sec. discharges, both double null and lower single null, for both ohmic and auxiliary heated discharges. We also discuss the vertical stability properties of the device

  19. Efficient LTE Access with Collision Resolution for Massive M2M Communications

    DEFF Research Database (Denmark)

    Madueño, Germán Corrales; Stefanovic, Cedomir; Popovski, Petar

    2014-01-01

    outage. In this work we propose a LTE RACH scheme tailored for delay-sensitive M2M services with synchronous traffic arrivals. The key idea is, upon detection of a RACH overload, to apply a collision resolution algorithm based on splitting trees. The solution is implemented on top of the existing LTE...

  20. checkCIF/PLATON report Datablock: ll5182-c2m

    Indian Academy of Sciences (India)

    THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: ll5182-c2m. Bond precision:.

  1. Performance of V-4Cr-4Ti Alloy Exposed to the JFT-2M Tokamak Environment

    International Nuclear Information System (INIS)

    Johnson, W.R.; Trester, P.W.; Sengoku, S.; Ishiyama, S.; Fukaya, K.; Eto, M.; Oda, T.; Hirohata, Y.; Hino, T.; Tsai, H.

    1999-01-01

    A long-term test has been conducted in the JFT-2M tokamak fusion device to determine the effects of environmental exposure on the mechanical and chemical behavior of a V-4Cr-4Ti alloy. Test specimens of the alloy were exposed in the outward lower divertor chamber of JFT-2M in a region away from direct contact with the plasma and were preheated to 300 C just prior to and during selected plasma discharges. During their nine-month residence time in JFT-2M, the specimens experienced approximately 200 lower single-null divertor shots at 300 C, during which high energy particle fluxes to the preheated test specimens were significant, and approximately 2,010 upper single-null divertor shots and non-diverter shots at room temperature, for which high energy particle fluxes to and expected particle retention in the test specimens were very low. Data from post-exposure tests have indicated that the performance of the V-4Cr-4Ti alloy would not be significantly affected by environmental exposure to gaseous species at partial pressures typical for tokamak operation. Deuterium retention in the exposed alloy was also low (<2 ppm). Absorption of interstitial by the alloy was limited to the very near surface, and neither the strength nor the Charpy impact properties of the alloy appeared to be significantly changed from the exposure to the JFT-2M tokamak environment

  2. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    NELSON, R.L.

    2000-06-06

    The CH2M HILL Hanford Group, Inc. (CHG), Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project waste tank farm.

  3. Exploiting the Capture Effect to Enhance RACH Performance in Cellular-Based M2M Communications

    Directory of Open Access Journals (Sweden)

    Jonghun Kim

    2017-09-01

    Full Text Available Cellular-based machine-to-machine (M2M communication is expected to facilitate services for the Internet of Things (IoT. However, because cellular networks are designed for human users, they have some limitations. Random access channel (RACH congestion caused by massive access from M2M devices is one of the biggest factors hindering cellular-based M2M services because the RACH congestion causes random access (RA throughput degradation and connection failures to the devices. In this paper, we show the possibility exploiting the capture effects, which have been known to have a positive impact on the wireless network system, on RA procedure for improving the RA performance of M2M devices. For this purpose, we analyze an RA procedure using a capture model. Through this analysis, we examine the effects of capture on RA performance and propose an Msg3 power-ramping (Msg3 PR scheme to increase the capture probability (thereby increasing the RA success probability even when severe RACH congestion problem occurs. The proposed analysis models are validated using simulations. The results show that the proposed scheme, with proper parameters, further improves the RA throughput and reduces the connection failure probability, by slightly increasing the energy consumption. Finally, we demonstrate the effects of coexistence with other RA-related schemes through simulation results.

  4. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    International Nuclear Information System (INIS)

    NELSON, R.L.

    2000-01-01

    The CH2M HILL Hanford Group, Inc. (CHG), Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project waste tank farm

  5. INSTRUMENTOS NACIONALES E INTERNACIONALES DE PROTECCION A LOS DERECHOS HUMANOS Y AL D.I.H. VIOLADOS POR LAS FUERZAS MILITARES CON EL DELITO DE EJECUCIONES EXTRAJUDICIALES EN COLOMBIA

    OpenAIRE

    Gonzalez Suescun, Leonardo; Mariño, Martha; Velasquez Villamarin, Carlos Antonio

    2010-01-01

    Uno de los fenómenos que durante años se ha presentado en el país y que en los últimos meses ha cobrado fuerza, son las ejecuciones extrajudiciales ya que dicha práctica evidencia violaciones concretas y directas de Derechos Humanos e infracciones al Derecho Internacional Humanitario. Los falsos positivos son un extremo del espectro de infracciones al Derecho Internacional Humanitario y violaciones a los Derechos Humanos por parte de la Fuerza Pública. Los falsos positivos, es preciso in...

  6. Relación entre la fuerza y la electromiografía (EMG) del vasto interno del cuádriceps, en movimientos de media sentadilla con carga

    OpenAIRE

    García-Fogeda, A.; Usach Minguillón, R.

    2008-01-01

    El objetivo del presente trabajo es analizar la relación existente entre la señal electromiográfica (EMG) del vasto interno del cuadriceps y los registros de fuerza vertical en una plataforma de fuerzas, durante un movimiento repetitivo y continuo de media sentadilla, con una carga del peso corporal (PC). Para cuantificar dicha relación se ha estimado el coeficiente de correlación bivariada de Pearson con el software SPSS v.11 tanto en la totalidad del movimiento, como por separado en fases e...

  7. Efectos del ejercicio aeróbico interválico, combinado con entrenamiento de fuerza y de la restricción calórica, sobre la composición corporal de ratas obesas

    OpenAIRE

    I. Coll-Risco; D. Camiletti-Moirón; D.J. Tirado; E. Nebot; A. Andrade; R. Martínez; G. Kapravelou; J.M. Porres; P. Aranda; V.A. Aparicio

    2017-01-01

    Objetivo: Investigar los efectos de un programa de ejercicio aeróbico interválico, combinado con entrenamiento de fuerza, y de la restricción calórica, sobre el peso y la composición corporal de ratas genéticamente obesas. Método: Un total de 32 ratas genéticamente obesas fueron divididas aleatoriamente en dos grupos (n = 16) con o sin ejercicio aeróbico interválico combinado con entrenamiento de fuerza. A su vez, cada grupo, con o sin ejercicio aeróbico interválico combinado con entrenami...

  8. Efectos del ejercicio aeróbico interválico, combinado con entrenamiento de fuerza y de la restricción calórica, sobre la composición corporal de ratas obesas

    OpenAIRE

    Coll-Risco, I.; Camiletti-Moirón, D.; Tirado, D.J.; Nebot, E.; Andrade, A.; Martínez, R.; Kapravelou, G.; Porres, J.M.; Aranda, P.; Aparicio, V.A.

    2017-01-01

    Resumen Objetivo: Investigar los efectos de un programa de ejercicio aeróbico interválico, combinado con entrenamiento de fuerza, y de la restricción calórica, sobre el peso y la composición corporal de ratas genéticamente obesas. Método: Un total de 32 ratas genéticamente obesas fueron divididas aleatoriamente en dos grupos (n = 16) con o sin ejercicio aeróbico interválico combinado con entrenamiento de fuerza. A su vez, cada grupo, con o sin ejercicio aeróbico interválico combinado con en...

  9. Análisis de la disminución de fuerza de agarre en la mano por uso de guante en actividades de aseo y cafetería

    OpenAIRE

    Zea, Christian Ricardo; Caro, Martha Patricia; Quintana, Leonardo Augusto

    2016-01-01

    En la literatura existen estudios relacionados con la disminución de fuerza por el uso de guante en actividades de riesgo como aviación o mantenimiento eléctrico. Sin embargo, no ha sido estudiado este factor en tareas de aseo y cafetería, en las que el uso de guantes es necesario. Objetivos: responder a la pregunta sobre la existencia de efecto en la fuerza de agarre por el uso de guante y postura en esta población que se caracteriza por su vulnerabilidad e incidencia en lesiones musculoesqu...

  10. Análisis de la disminución de fuerza de agarre en la mano por uso de guantes en actividades de aseo y cafetería

    OpenAIRE

    Zea, Christian Ricardo; Caro, Martha Patricia; Quintana, Leonardo Augusto

    2016-01-01

    Introducción: existen en la literatura estudios relacionados con la disminución de fuerza por el uso de guantes en actividades de riesgo, como aviación o mantenimiento eléctrico. Sin embargo, no ha sido estudiado este factor en tareas de aseo y cafetería, donde el uso de guantes es necesario. Se pretende entonces responder a la pregunta, si existe efecto en la fuerza de agarre por el uso de guantes y postura en esta población que se caracteriza por su vulnerabilidad e incidencia en lesiones m...

  11. Ionic conductivity in irradiated KCL; Conductiviad ionica de KCL irradiado

    Energy Technology Data Exchange (ETDEWEB)

    Vignolo Rubio, J

    1979-07-01

    The ionic conductivity of X and gamma irradiated KCL single crystals has been studied between room temperature and 600 degree centigree. the radiation induced damage resulting in a decrease of the conductivity heals by thermal annealing in two steps which are at about 350 and 550 degree centigree respectively. It has been found that the radiation induced colour centres are not involved in the observed decrease of the ionic conductivity. However. It has been observed that the effects of quenching and plastic deformation on the conductivity of the samples are very similar to the effect induced by irradiation. It is suggested that, samples radiation induced dislocation loops might cause the ionic conductivity decrease observed in irradiated samples. (Author)

  12. [Impacts of the formula of Suoquanwan(SQW) on expression of AQP-2 mRNA and AVPR-V2 mRNA in the kidney of rat polyuria model of Yang-deficiency].

    Science.gov (United States)

    Cao, Hong-Ying; Wu, Qing-He; Huang, Ping; He, Jin-Yang

    2009-06-01

    To observe the impacts of the formula of Suoquanwan (SQW) on the expression of AQP-2 mRNA and AVPR-V2 mRNA in the kidney of rat polyuria model of Yang-deficiency. The model rats were induced by adenine (250 mg/kg) for 4 weeks, then treated respectively with SQW or dDAVP. The expression of AQP-2 mRNA and AVPR-V2 mRNA in kidney of Yang-deficiency model by realtime fluorescence quantitative PCR method were investigated. In model rats, the expression of AQP-2 mRNA and AVPR-V2 mRNA in the kidney decreased, dDAVP and SQW high dose could increased the expression of AQP-2 mRNA and AVPR-V2 mRNA in the kidney. The others had no influence on the expression of AQP-2 mRNA and AVPR-V2 mRNA in the kidney. SQW can increase the expression of AQP-2 mRNA and AVPR-V2 mRNA in the kidney of rat polyuria model of Yang-deficiency.

  13. Expression and significance of cyclooxygenase-2 mRNA in benign and malignant ascites

    Science.gov (United States)

    Lu, Jing; Li, Xiao-Feng; Kong, Li-Xia; Ma, Lin; Liao, Su-Huan; Jiang, Chang-You

    2013-01-01

    AIM: To investigate the mRNA expression of cyclooxygensae-2 (COX-2) in benign and malignant ascites, and to explore the difference in COX-2 mRNA expression among different diseases. METHODS: A total of 36 samples were collected from the Fifth Affiliated Hospital of Sun Yat-Sen University and divided into two experimental groups: benign ascites (n = 21) and malignant ascites (n = 15). Benign ascites included cirrhotic ascites (n = 10) and tuberculous ascites (n = 5). Malignant ascites included oophoroma (n = 7), cancer of colon (n = 5), cancer of the liver (n = 6), gastric cancer (n = 2), and bladder carcinoma (n = 1). The mRNA expression of COX-2 in ascites was examined with reverse transcriptase polymerase chain reaction (RT-PCR) technology, and the positive rate of COX-2 mRNA was compared between different diseases. RESULTS: The positive rate of COX-2 mRNA in malignant ascites was 42.9% (9/21), which was significantly higher than in benign ascites, 6.7% (1/15), difference being significant between these two groups (χ2 = 4.051, P = 0.044). The proportion of the positive rate in the malignant ascites was as follows: ovarian cancers 57.1% (4/7), colon cancer 40.0% (2/5), liver cancer 33.3% (2/6), gastric cancer 50.0% (1/2), and bladder cancer 0.00% (0/1). However, there was no significant difference in COX-2 mRNA expression among various tumors with malignant ascites (χ2 = 1.614, P = 0.806). Among the benign ascites, COX-2 mRNA levels were different between the tuberculous ascites (0/5) and cirrhotic ascites (1/10), but there was no significant difference (P = 1.000). CONCLUSION: COX-2 mRNA, detected by RT-PCR, is useful in the differential diagnosis of benign and malignant ascites, which also has potential value in the clinical diagnosis of tumors. PMID:24187465

  14. Current state and prospects of the IBR-2M instrument control software

    International Nuclear Information System (INIS)

    Kirilov, A.S.

    2011-01-01

    The article is devoted to the main features and plans of future improvements of the Sonix + instrumental complex, which is used now to control experimental hardware at the IBR-2M spectrometers. The Sonix + software inherited basic solutions from the older Sonix system. In particular, those are the modular organization using special database for device control and reflection of the current system state, using script programming for the measured procedure. At the same time, some basic features were revised to make the system more unified, flexible and comfortable for the user. Main changes can be grouped as follows: structural enhancements, using the Python as a script language, GUI redesign and unification, remote supervision and instrument control via network. During the last years, this complex has been tested at some IBR-2 instruments (REMUR, NERA-PR) and on some instruments at other centers. We are planning to install it at the other instruments of IBR-2M as well

  15. Estimation of power feedback parameters of the IBR-2M reactor by square wave reactivity

    International Nuclear Information System (INIS)

    Pepelyshev, Yu.N.; Popov, A.K.; Sumkhuu, D.

    2016-01-01

    Parameters of the IBR-2M reactor power feedback (PFB) are estimated based on the analysis of power transients caused by deliberate square wave reactivity when the pulsed reactor operates in the self-regulation mode. The PFB of the IBR-2M is described by three linear first-order differential equations. Two components of the PFB are responsible for the negative feedback and one, for the positive. The overall feedback is negative, i.e., it has a stabilizing effect for the operation of the reactor. The slowest negative component of the PFB is probably caused by heating of the fuel. Periodically repeated in the process of exploitation, estimation of the PFB parameters is one of the methods to ensure safety operation of the reactor. [ru

  16. Access Control in IoT/M2M - Cloud Platform

    DEFF Research Database (Denmark)

    Anggorojati, Bayu

    Billions of devices are connected to the Internet nowadays, and the number will continue to grow in the future thanks to the advances in the electronics and telecommunication technology developments. Its application in broad aspects of human’s life brings a lot of benefits by improving productivity...... and quality of life. This paradigm, which is often called Internet of Things (IoT) or Machine-to-Machine (M2M), will provide an unprecedented opportunity to create applications and services that go far beyond the mere purpose of each participant. Many studies on the both technical and social aspects of Io......T have shown that the concern about the security and privacy play a huge role for the mass adoption of the IoT/M2M as cloud services. Among the important topics within the security and privacy, the access control is an important mechanism, which essentially manages how the important assets or resource...

  17. Experimental verification of FA for WWER-1000. Investigations of TVS - 2M

    International Nuclear Information System (INIS)

    Vasilchenko, I.; Seleznev, A.; Kobelev, S.; Makarov, V.; Afanasjev, A.; Matvienko, I.; Enin, A.; Ustimenko, A.; Volkov, S.

    2008-01-01

    During development of TVS-2M design for WWER-1000 and within the scope of its pre-reactor verification there was performed a complex of bench tests of FA for operational impacts. These tests were carried out with the use of the full-scale non-irradiated FA dummy and the models of units. The present report presents the methods and the results of tests of the full-scale dummy for static concentrated loads, impact of thermal cycling and vibration under separate and simultaneous impact of the listed loads. The results of tests carried out indicate that the solutions implemented in TVS-2M, first of all, a rigid welded skeleton, provide much higher resistance to distortion due to thermomechanical loads in comparison with zirconium AFA of the previous generation. This work was organized by JSC TVEL. (authors)

  18. Zeatin is indispensable for the G2-M transition in tobacco BY-2 cells.

    Science.gov (United States)

    Laureys, F; Dewitte, W; Witters, E; Van Montagu, M; Inzé, D; Van Onckelen, H

    1998-04-10

    The importance of N6-isoprenoid cytokinins in the G2-M transition of Nicotiana tabacum BY-2 cells was investigated. Both cytokinin biosynthesis and entry in mitosis were partially blocked by application at early or late G2 of lovastatin (10 microM), an inhibitor of mevalonic acid synthesis. LC-MS/MS quantification of endogenous cytokinins proved that lovastatin affects cytokinin biosynthesis by inhibiting HMG-CoA reductase. Out of eight different aminopurines and a synthetic auxin tested for their ability to override lovastatin inhibition of mitosis, only zeatin was active. Our data point to a key role for a well-defined cytokinin (here, zeatin) in the G2-M transition of tobacco BY-2 cells.

  19. Industry 4.0, M2m, Iot&S - All Equal?

    Science.gov (United States)

    Dobrin, Carmen

    2014-11-01

    Similarity between Industry 4.0, M2M, IOT&S. Advantages and disadvantages obtained using this three important methods. Decreasing costs while components are getting smaller and smaller in a world with better networking. Influence of business management applications integrated in smart factory logistic. The most important impacts in merging virtual and real production world, with the improvement of best processes having the same goal: creating value by open innovation

  20. UCP2 mRNA expression is dependent on glucose metabolism in pancreatic islets

    DEFF Research Database (Denmark)

    Dalgaard, Louise Torp

    2012-01-01

    Uncoupling Protein 2 (UCP2) is expressed in the pancreatic β-cell, where it partially uncouples the mitochondrial proton gradient, decreasing both ATP-production and glucose-stimulated insulin secretion (GSIS). Increased glucose levels up-regulate UCP2 mRNA and protein levels, but the mechanism f...... down-regulation of UCP2 is involved in preserving the insulin secretory capacity of GK mutant mice and might also be implicated in limiting disease progression in MODY2 patients....

  1. Power Aware Mobility Management of M2M for IoT Communications

    Directory of Open Access Journals (Sweden)

    Awais Ahmad

    2015-01-01

    Full Text Available Machine-to-Machine (M2M communications framework is evolving to sustain faster networks with the potential to connect millions of devices in the following years. M2M is one of the essential competences for implementing Internet of Things (IoT. Therefore, various organizations are now focusing on enhancing improvements into their standards to support M2M communications. Thus, Heterogeneous Mobile Ad Hoc Network (HetMANET can normally be considered appropriate for M2M challenges. These challenges incorporated when a mobile node (MN selects a target network in an energy efficient scanning for efficient handover. Therefore, to cope with these constraints, we proposed a vertical handover scheme for handover triggering and selection of an appropriate network. The proposed scheme is composed of two phases. Firstly, the MNs perform handover triggering based on the optimization of the Receive Signal Strength (RSS from an access point/base station (AP/BS. Secondly, the network selection process is performed by considering the cost and energy consumption of a particular application during handover. Moreover, if there are more networks available, then the MN selects the one provided with the highest quality of service (QoS. The decision regarding the selection of available networks is made on three metrics, that is, cost, energy, and data rate. Furthermore, the selection of an AP/BS of the selected network is made on five parameters: delay, jitter, Bit Error Rate (BER, communication cost, and response time. The numerical and experimental results are compared in the context of energy consumption by an MN, traffic management on an AP/BS, and QoS of the available networks. The proposed scheme efficiently optimizes the handoff related parameters, and it shows significant improvement in the existing models used for similar purpose.

  2. Density peaking in the JFT-2M tokamak plasma with counter neutral beam injection

    International Nuclear Information System (INIS)

    Ida, K.; Itoh, S.; Itoh, K.

    1991-05-01

    A significant particle pinch and reduction of the effective thermal diffusivity are observed after switching the neutral beam direction from co- to counter- injection in the JFT-2M tokamak. A time delay in the occurrence of density peaking to that of plasma rotation is found. This shows that the particle pinch is related to the profile of the electric field as determined by the plasma rotation profile. The measured particle flux shows qualitative agreement with the theoretically-predicted inward pinch. (author)

  3. Detailed profile of m=2 islands with TVTS on JFT-2M

    International Nuclear Information System (INIS)

    Yamauchi, T.; Grek, B.; Hoshino, K.; Le Blanc, B.; Johnson, D.; Felt, J.; Shiina, T.; Kurita, G.; Ishige, Y.; Kozawa, H.

    1996-01-01

    The detailed electron temperature profile (spatial resolution: 0.86 cm) of a low density JFT-2M plasma is measured with the TV Thomson scattering system (TVTS). Flat profiles showing the electron temperature shapes of m=2/n=1 islands are presented, which are in contrast to that without islands. On the other hand, the m=2/n=1 islands are effectively suppressed with local ECRH heating. (orig.)

  4. RESTful M2M Gateway for Remote Wireless Monitoring for District Central Heating Networks

    Directory of Open Access Journals (Sweden)

    Bo Cheng

    2014-11-01

    Full Text Available In recent years, the increased interest in energy conservation and environmental protection, combined with the development of modern communication and computer technology, has resulted in the replacement of distributed heating by central heating in urban areas. This paper proposes a Representational State Transfer (REST Machine-to-Machine (M2M gateway for wireless remote monitoring for a district central heating network. In particular, we focus on the resource-oriented RESTful M2M gateway architecture, and present an uniform devices abstraction approach based on Open Service Gateway Initiative (OSGi technology, and implement the resource mapping mechanism between resource address mapping mechanism between RESTful resources and the physical sensor devices, and present the buffer queue combined with polling method to implement the data scheduling and Quality of Service (QoS guarantee, and also give the RESTful M2M gateway open service Application Programming Interface (API set. The performance has been measured and analyzed. Finally, the conclusions and future work are presented.

  5. Seamless communication in supply chains based on M2M technology

    Directory of Open Access Journals (Sweden)

    Walid Moneimne

    2016-12-01

    Full Text Available Background: Access to information is the key element in the successful and efficient organization of transport & logistic processes. The importance of real-time access to information is confirmed by a panel workshop carried out with support of design thinking methodology. There are two ways of gaining access to the right information - manual, where human agency is needed and fully automatic, where new M2M technology is implemented. Implementation of such technology improves seamless communication during transport execution and allows real-time access to needed information. The aim of the paper is to evaluate the influence of the effectiveness of using M2M technology and traditional way of communication as well as data gathering in order to ensure seamless communication in the supply chain. Methods: Survey, design thinking, desk research and real case study results were used in the paper. Results and conclusions: Seamless communication and implementation of M2M technology within the whole supply (including modes of transport and transport units chain is a backbone of the lean and reliable digital supply chain.

  6. Dynamic RACH Partition for Massive Access of Differentiated M2M Services

    Directory of Open Access Journals (Sweden)

    Qinghe Du

    2016-03-01

    Full Text Available In machine-to-machine (M2M networks, a key challenge is to overcome the overload problem caused by random access requests from massive machine-type communication (MTC devices. When differentiated services coexist, such as delay-sensitive and delay-tolerant services, the problem becomes more complicated and challenging. This is because delay-sensitive services often use more aggressive policies, and thus, delay-tolerant services get much fewer chances to access the network. To conquer the problem, we propose an efficient mechanism for massive access control over differentiated M2M services, including delay-sensitive and delay-tolerant services. Specifically, based on the traffic loads of the two types of services, the proposed scheme dynamically partitions and allocates the random access channel (RACH resource to each type of services. The RACH partition strategy is thoroughly optimized to increase the access performances of M2M networks. Analyses and simulation demonstrate the effectiveness of our design. The proposed scheme can outperform the baseline access class barring (ACB scheme, which ignores service types in access control, in terms of access success probability and the average access delay.

  7. Cells bearing chromosome aberrations lacking one telomere are selectively blocked at the G2/M checkpoint

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, Pilar [Unitat de Biologia Cel.lular, Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Barquinero, Joan Francesc [Unitat d' Antropologia Biologica, Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Duran, Assumpta [Unitat de Biologia Cel.lular, Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Caballin, Maria Rosa [Unitat d' Antropologia Biologica, Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Ribas, Montserrat [Servei de Radiofisica i Radioproteccio de l' Hospital de la Santa Creu i Sant Pau, 08025 Barcelona (Spain); Barrios, Leonardo, E-mail: Lleonard.Barrios@uab.cat [Unitat de Biologia Cel.lular, Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain)

    2009-11-02

    Cell cycle checkpoints are part of the cellular mechanisms to maintain genomic integrity. After ionizing radiation exposure, the cells can show delay or arrest in their progression through the cell cycle, as well as an activation of the DNA repair machinery in order to reduce the damage. The G2/M checkpoint prevents G2 cells entering mitosis until the DNA damage has been reduced. The present study evaluates which G0 radiation-induced chromosome aberrations are negatively selected in the G2/M checkpoint. For this purpose, peripheral blood samples were irradiated at 1 and 3 Gy of {gamma}-rays, and lymphocytes were cultured for 48 h. Calyculin-A and Colcemid were used to analyze, in the same slide, cells in G2 and M. Chromosome spreads were consecutively analyzed by solid stain, pancentromeric and pantelomeric FISH and mFISH. The results show that the frequency of incomplete chromosome elements, those lacking a telomeric signal at one end, decreases abruptly from G2 to M. This indicates that cells with incomplete chromosome elements can progress from G0 to G2, but at the G2/M checkpoint suffer a strong negative selection.

  8. Cells bearing chromosome aberrations lacking one telomere are selectively blocked at the G2/M checkpoint

    International Nuclear Information System (INIS)

    Rodriguez, Pilar; Barquinero, Joan Francesc; Duran, Assumpta; Caballin, Maria Rosa; Ribas, Montserrat; Barrios, Leonardo

    2009-01-01

    Cell cycle checkpoints are part of the cellular mechanisms to maintain genomic integrity. After ionizing radiation exposure, the cells can show delay or arrest in their progression through the cell cycle, as well as an activation of the DNA repair machinery in order to reduce the damage. The G2/M checkpoint prevents G2 cells entering mitosis until the DNA damage has been reduced. The present study evaluates which G0 radiation-induced chromosome aberrations are negatively selected in the G2/M checkpoint. For this purpose, peripheral blood samples were irradiated at 1 and 3 Gy of γ-rays, and lymphocytes were cultured for 48 h. Calyculin-A and Colcemid were used to analyze, in the same slide, cells in G2 and M. Chromosome spreads were consecutively analyzed by solid stain, pancentromeric and pantelomeric FISH and mFISH. The results show that the frequency of incomplete chromosome elements, those lacking a telomeric signal at one end, decreases abruptly from G2 to M. This indicates that cells with incomplete chromosome elements can progress from G0 to G2, but at the G2/M checkpoint suffer a strong negative selection.

  9. Cdk2 is required for p53-independent G2/M checkpoint control.

    Directory of Open Access Journals (Sweden)

    Jon H Chung

    2010-02-01

    Full Text Available The activation of phase-specific cyclin-dependent kinases (Cdks is associated with ordered cell cycle transitions. Among the mammalian Cdks, only Cdk1 is essential for somatic cell proliferation. Cdk1 can apparently substitute for Cdk2, Cdk4, and Cdk6, which are individually dispensable in mice. It is unclear if all functions of non-essential Cdks are fully redundant with Cdk1. Using a genetic approach, we show that Cdk2, the S-phase Cdk, uniquely controls the G(2/M checkpoint that prevents cells with damaged DNA from initiating mitosis. CDK2-nullizygous human cells exposed to ionizing radiation failed to exclude Cdk1 from the nucleus and exhibited a marked defect in G(2/M arrest that was unmasked by the disruption of P53. The DNA replication licensing protein Cdc6, which is normally stabilized by Cdk2, was physically associated with the checkpoint regulator ATR and was required for efficient ATR-Chk1-Cdc25A signaling. These findings demonstrate that Cdk2 maintains a balance of S-phase regulatory proteins and thereby coordinates subsequent p53-independent G(2/M checkpoint activation.

  10. Staphylococcus aureus Lpl Lipoproteins Delay G2/M Phase Transition in HeLa Cells.

    Science.gov (United States)

    Nguyen, Minh-Thu; Deplanche, Martine; Nega, Mulugeta; Le Loir, Yves; Peisl, Loulou; Götz, Friedrich; Berkova, Nadia

    2016-01-01

    The cell cycle is an ordered set of events, leading to cell growth and division into two daughter cells. The eukaryotic cell cycle consists of interphase (G 1 , S, and G 2 phases), followed by the mitotic phase and G 0 phase. Many bacterial pathogens secrete cyclomodulins that interfere with the host cell cycle. In Staphylococcus aureus four cyclomodulins have been described so far that all represent toxins and are secreted into the culture supernatant. Here we show that the membrane-anchored lipoprotein-like proteins (Lpl), encoded on a genomic island called νSaα, interact with the cell cycle of HeLa cells. By comparing wild type and lpl deletion mutant it turned out that the lpl cluster is causative for the G2/M phase transition delay and also contributes to increased invasion frequency. The lipoprotein Lpl1, a representative of the lpl cluster, also caused G2/M phase transition delay. Interestingly, the lipid modification, which is essential for TLR2 signaling and activation of the immune system, is not necessary for cyclomodulin activity. Unlike the other staphylococcal cyclomodulins Lpl1 shows no cytotoxicity even at high concentrations. As all Lpl proteins are highly conserved there might be a common function that is accentuated by their multiplicity in a tandem gene cluster. The cell surface localized Lpls' suggests a correlation between G2/M phase transition delay and host cell invasion.

  11. Un estudio sobre las investigaciones acerca de las ideas de los estudiantes en fuerza y movimiento A study on researches about students ideas on force and motion

    Directory of Open Access Journals (Sweden)

    Silvia Giorgi

    2005-04-01

    Full Text Available Se llevó a cabo un análisis exhaustivo de publicaciones sobre preconcepciones o ideas iniciales referidas al tema "cuerpos en movimiento", también comúnmente denominado "fuerza y movimiento". Se estudiaron los aspectos teóricos, metodológicos y conceptuales involucrados en una muestra de investigaciones consistente en 36 trabajos publicados en revistas especializadas y en libros de distintas procedencias y autores. Los sujetos participantes en las investigaciones abarcan distintos niveles y tipos de instrucción. Los resultados revelan, por un lado la existencia de distintos objetivos, diferentes posturas asumidas por los investigadores con relación a las ideas iniciales, fuentes de datos utilizadas variadas, así como heterogeneidad en los resultados obtenidos y en su interpretación. Por otro lado, del estudio realizado surge que si bien los sujetos no poseen una conceptualización científica de fuerza, en las representaciones que ellos construyen de los fenómenos mecánicos podrían estar involucradas significaciones del término Fuerza asociadas a otras magnitudes físicas tales como cantidad de movimiento y energía. Se concluye en la necesidad de abordar el problema de las preconcepciones desde una nueva perspectiva tanto teórica como metodológica.An exhaustive analysis of publications about human preconceptions or initial ideas in regard to "bodies in movement" was carried out. Theoretical, methodological and conceptual aspects of a sample of 36 works on individuals of diverse levels of instruction and published in journals and books of different origins, were studied. Our findings revealed a great variety of goals as well as of postures assumed by the investigators with respect to preconceptions. Types of data sources as well as results and their interpretation showed also a great dispersion. From another point of view, the results of the present study suggest that although the subjects' conceptualization of force may be wrong

  12. Efectos del ejercicio aeróbico interválico, combinado con entrenamiento de fuerza y de la restricción calórica, sobre la composición corporal de ratas obesas

    Directory of Open Access Journals (Sweden)

    I. Coll-Risco

    2017-03-01

    Conclusiones: Tanto el programa de ejercicio aeróbico interválico, combinado con entrenamiento de fuerza desarrollado, como la restricción calórica, fueron eficaces, mejorando la composición corporal de ratas obesas, pero el ejercicio lo hizo en mayor magnitud.

  13. Study of the efficiency of two strength program training in the Climbing’s yield Estudio de la eficacia de dos programas de entrenamiento de la fuerza en el rendimiento de la escalada deportiva

    Directory of Open Access Journals (Sweden)

    S. Sedano

    2010-09-01

    Full Text Available The main aim of the current study was to determine the effectiveness of two strength training for climbing. 30 healthy men participated in the present study, and they were randomly divided into three groups: control group (GC (n=10, maximal strength training group (GFM and endurance-strength training group (GFR. The three groups trained three days per week, GC trained always in wall, but GFM and GFR changed one of them for a training session in the gym. The program lasted 10 weeks and we assesed different kinds of variables before and after the training: physical conditioning variables and hand-grip strength after climbing. We found significant differences in the three groups analysed. GFR obtained the best results according to climbing demands and GFM also obtained significant differences but not as specific as GFR. It could be said that endurance-strength training is the best for climbing.

    Key Words:Climbing, training, maximal strength, endurance-strength.

    El objetivo principal de este trabajo es estudiar la efectividad de dos programas de entrenamiento sobre algunos aspectos relacionados con las demandas específicas para el rendimiento en la escalada. Para ello se han utilizado tres grupos de sujetos: grupo control (GC (n=10 y dos grupos de entrenamiento, uno de fuerza máxima (GFM (n=10 y otro de fuerza resistencia (GFR (n=10, todos ellos con ligera experiencia en la práctica de la escalada. Los grupos entrenaron tres días a la semana, GC en rocódromo y GFM y GFR cambiaron un día de trabajo en rocódromo por uno en el gimnasio. Antes y después del entrenamiento se realizaron diferentes pruebas de valoración de la condición física y de factores específicos de escalada, (pre-test; post-test. En sujetos con poca experiencia los tres tipos de entrenamiento producen mejoras, siendo el trabajo de fuerza-resistencia, el que

  14. Ideas previas sobre carga, fuerza y campo eléctrico en estudiantes universitarios. Consideraciones para su superación

    Directory of Open Access Journals (Sweden)

    Marianela Nava

    2008-05-01

    Full Text Available El presente trabajo trata sobre el valor didáctico de las ideas previas de los estudiantes para la construcción de nuevos saberes, que lo posibiliten para dar explicaciones acordes con el conocimiento científico. Luego del análisis de los datos, se plantea el diseño de situaciones didácticas, fundamentadas en Posner et al, Ausubel, Amestoy, Alonso et al, que permitan promover la construcción de conceptos, aplicable a diversos campos. El estudio se encuentra enmarcado en un paradigma cuali-cuantitativo, a nivel descriptivo. Una conclusión importante es que las nociones sobre campo eléctrico, resultaron más deficientes que las de carga, pero menos que las de fuerza eléctrica, siendo necesario fomentar la construcción de conceptos científicos en los estudiantes universitarios.

  15. Análisis de la fuerza isométrica en trampolinistas españoles de distintas categorías competitivas

    OpenAIRE

    Gómez-Landero Rodríguez, Luis Arturo; López Bedoya, Jesús; Vernetta Santana, Mercedes; Marina Evrad, Michel

    2012-01-01

    Introducción: Debido a la ausencia de trabajos que describan y analicen el perfil de fuerza isométrica en Trampolín y su relación con el rendimiento deportivo, se plantea un estudio transversal, comparativo y correlacional en esta línea con trampolinistas españoles. Método: Muestra compuesta por 60 trampolinistas de élite nacional, agrupados por categoría competitiva en 4 grupos: 1) Sub-15 masculino (n = 23; 11,95 ± 1,79 años), 2) Sub-15 femenino (n = 9; 11,44 ± 1,23 años), 3) Absoluto mascul...

  16. Análisis de la fuerza isométrica en trampolinistas españoles de distintas categorías competitivas

    OpenAIRE

    Luis Arturo Gómez-Landero Rodríguez; Jesús López Bedoya; Mercedes Vernetta Santana; Michel Marina Evrad

    2015-01-01

    Introducción: Debido a la ausencia de trabajos que describan y analicen el perfil de fuerza isométrica en Trampolín y su relación con el rendimiento deportivo, se plantea un estudio transversal, comparativo y correlacional en esta línea con trampolinistas españoles. Método: Muestra compuesta por 60 trampolinistas de élite nacional, agrupados por categoría competitiva en 4 grupos: 1) Sub-15 masculino (n = 23; 11,95 ± 1,79 años), 2) Sub-15 femenino (n = 9; 11,44 ± 1,23 años), 3) Absoluto mascul...

  17. Prototipo de simulador de tornado para el combate Aéreo No. 3 (CACOM 3 de la Fuerza Aérea Colombiana (FAC

    Directory of Open Access Journals (Sweden)

    Jorge Mario Cárdenas Cabrera

    2012-09-01

    El comando CACOM 3 de la Fuerza Aérea Colombiana (FAC ha tomado la iniciativa en este aspecto y se ha dado a la tarea de estudiar este fenómeno, trabajando en el diseño de un simulador de tornados a escala, con base en el ya existente, desarrollado por el phD. Harald Eddens, introdujo modificaciones que permitan, además de generar el fenómeno, medir y controlar a través de dispositivos electrónicos algunas variables ambientales. Estos dispositivos permitirán iniciar estudios desde el comando y servir de apoyo para labores de educación de la población vulnerable en cuanto a entender cómo se forma un tornado.

  18. Sobre condiciones suficientes de estabilidad para sistemas mecánicos sometidos a fuerzas dependientes de la velocidad por el método directo de Liapunov

    Directory of Open Access Journals (Sweden)

    Rodríguez Rebollo, Rafael

    1979-05-01

    Full Text Available Consideramos la estabilidad de un estado de un sistema mecánico, discreto o continuo, sometido a fuerzas generalizadas dependientes o no de la velocidad y cuyas ecuaciones variacionales de movimiento, para pequeñas perturbaciones, son ecuaciones diferenciales de segundo orden respecto del tiempo y de una estructura formal frecuente en diversos problemas de estabilidad de medios continuos y de sistemas de partículas y de sólidos rígidos. Se obtienen criterios de estabilidad y de estabilidad asintótica según Liapunov por el método directo, generalizando resultados conocidos. Son condiciones de estabilidad condicional para soluciones de tipo exponencial respecto del tiempo.

  19. Intervencionismo militar y cambio de régimen político: la relación entre conservadurismo y fuerzas armadas en la Argentina

    Directory of Open Access Journals (Sweden)

    María Elina Zacarías

    2017-01-01

    Full Text Available Este artículo se propone estudiar el fenómeno del intervencionismo militar en la Argentina desde un enfoque que privilegia el análisis de las relaciones entre las fuerzas armadas y los partidos políticos conservadores. Con el foco puesto en la última experiencia de dictadura militar que tuvo lugar en el país (1976-1983, se desarrolla la tesis que postula una estrecha relación entre el grado de institucionalización de los partidos conservadores durante el periodo de la política de masas y la estabilidad del régimen democrático a lo largo del siglo XX.

  20. La pervivencia del Movimiento en la Transición: Fuerza Nueva en Almería y Jaén (1976-1982

    Directory of Open Access Journals (Sweden)

    Aurora M. Lorite Checa

    2009-12-01

    Full Text Available En el presente trabajo se propone una aproximación, nunca cerrada, a los mecanismos de acceso al poder de Fuerza Nueva en el período de transición a la democracia, al tiempo que un análisis de la mentalidad fuerzanuevista que por entonces caló en ciertos sectores de la sociedad de Almería y Jaén; ambos elementos, que aún tienen su proyección palpable en nuestros días, condicionaron la formación y la consolidación de un partido político ultra-conservador que actualmente se está reorganizando. Para ello se analizan la formación, las estructuras organizativas y la implantación territorial, las bases y apoyos sociales, el discurso político, la organización, espacios y actividad de los sectores juveniles, la proyección actual, y finalmente, los rasgos identitarios que dan lugar a la institucionalización de una cultura política propia._____________________ABSTRACT:This work analyzes the mechanisms of access to the power of Fuerza Nueva in the period of the transition to democracy, at the time that an analysis of this mentality lost a dialectic importance in certain sectors of the society of Almeria and Jaén; both elements, that still have their concrete projection in our days, conditioned the formation and the consolidation of an ultraconservative political party that at the moment are reorganizing themselves. For it, it has been analyzed the formation, organizational structures and the territorial implantation, social bases and supports, the political speech, the organization, spaces and activity of the youthful sectors, the present projection, and finally, the self-identification characteristics that give rise to the institutionalization of a peculiar political culture.

  1. Evaluación de la calidad superficial de piezas mecanizadas a partir del análisis de la fuerza de corte

    Directory of Open Access Journals (Sweden)

    Sánchez-Carrillero, M.

    1998-05-01

    Full Text Available Surface quality is one of the most important criteria for establishing the optima cutting parameters needed to perform a machining process. Usually, the evaluation of the degree of the surface finishing requires to apply metrological techniques which involve times out in the production. As a consequence of this, a loss in both the economy of the process and the fiability of the tests reproducibility can be produced. In this work a relation between cutting force and surface roughness has been studied for the turning process of an Al-Cu alloy. From this relation, the surface quality of the machined samples can be evaluated by using the cutting forces values acquired during the cutting process.

    El grado de acabado superficial de una pieza mecanizada es uno de los factores determinantes a la hora de establecer los parámetros de corte necesarios para llevar a cabo el proceso de mecanizado. Generalmente, la evaluación de ese grado de acabado requiere la aplicación de técnicas metrológicas que conllevan paradas de máquina y, a menudo, extracciones de piezas. Este hecho provoca la aparición de una serie de efectos negativos, no sólo en lo que a pérdidas económicas se refiere, sino a fiabilidad en la reproducción de los ensayos. En el presente trabajo se ha estudiado la relación existente entre la fuerza de corte y la rugosidad superficial para una aleación Al-Cu. A partir de esta relación se puede evaluar la calidad superficial de las muestras mecanizadas mediante la determinación de las fuerzas de corte durante el proceso.

  2. Evaluación de la fuerza de arrastre y optimización geométrica del cuerpo de un PIG con baipás

    Directory of Open Access Journals (Sweden)

    Ricardo Ramírez

    2011-05-01

    Full Text Available Un PIG es un dispositivo o vehículo que se desplaza entre ductos, siendo utilizado en operaciones de limpieza, medición e inspección, principalmente aplicado en oleoductos y gasoductos. Baipás es el nombre de uno o varios orificios que permiten el paso de fluido de atrás hacia adelante del PIG. Es utilizado para controlar la velocidad o para mejorar el resultado de las operaciones de limpieza. En gasoductos el baipás  controla las variaciones bruscas de velocidad, evitando daños en el PIG o el ducto. Estudios y algoritmos han sido desarrollados para simular la dinámica de los PIG y su paso por los ductos. La mayoría de estos estudios son sobre ductos con gas y han servido para el diseño de algunos modelos de PIG. Este trabajo describe parte del diseño de un PIG que trabaja con líquidos, capaz de realizar tareas de inspección o mantenimiento dentro del ducto. El estudio de la fuerza que ejerce el fluido en el PIG cuando tiene baja o nula velocidad es necesario para evaluar la viabilidad del proyecto y la concepción del diseño. Al mismo tiempo, definir una forma geométrica del PIG que minimice la fuerza de interacción con el fluido permite diseñar un PIG más liviano y que cause menores pérdidas de energía.

  3. Support optimization of the ring primary mirror of a 2m solar telescope

    Science.gov (United States)

    Yang, Dehua; Jin, Zhenyu; Liu, Zhong

    2016-08-01

    A special 2-m Ring Solar Telescope (2-m RST) is to be built by YNAO-Yunnan Astronomical Observatory, Kunming, China. Its distinct primary mirror is distinctively shaped in a ring with an outer diameter of 2.02 m and a ring width of 0.35 m. Careful calculation and optimization of the mirror support pattern have been carried out first of all to define optimum blank parameters in view of performance balance of support design, fabrication and cost. This paper is to review the special consideration and optimization of the support design for the unique ring mirror. Schott zerodur is the prevailing candidate for the primary mirror blank. Diverse support patterns with various blank thicknesses have been discussed by extensive calculation of axial support pattern of the mirror. We reached an optimum design of 36 axial supports for a blank thickness of 0.15 m with surface error of 5 nm RMS. Afterwards, lateral support scheme was figured out for the mirror with settled parameters. A classical push-and-pull scheme was used. Seeing the relative flexibility of the ring mirror, special consideration was taken to unusually set the acting direction of the support forces not in the mirror gravity plane, but along the gravity of the local virtual slices of the mirror blank. Nine couples of the lateral push-pull force are considered. When pointing to horizon, the mirror surface exhibits RMS error of 5 nm with three additional small force couples used to compensate for the predominant astigmatism introduced by lateral supports. Finally, error estimation has been performed to evaluate the surface degradation with introduced errors in support force and support position, respectively, for both axial and lateral supports. Monte Carlo approach was applied using unit seeds for amplitude and position of support forces. The comprehensive optimization and calculation suggests the support systems design meet the technic requirements of the ring mirror of the 2-m RST.

  4. Towards Efficient Mobile M2M Communications: Survey and Open Challenges

    Directory of Open Access Journals (Sweden)

    Carlos Pereira

    2014-10-01

    Full Text Available Machine-to-Machine (M2M communications enable networked devices and services to exchange information and perform actions seamlessly without the need for human intervention. They are viewed as a key enabler of the Internet of Things (IoT and ubiquitous applications, like mobile healthcare, telemetry, or intelligent transport systems. We survey existing work on mobile M2M communications, we identify open challenges that have a direct impact on performance and resource usage efficiency, especially the impact on energy efficiency, and we review techniques to improve communications. We review the ETSI standard and application protocols, and draw considerations on the impact of their use in constrained mobile devices. Nowadays, smartphones are equipped with a wide range of embedded sensors, with varied local and wide area connectivity capabilities, and thus they offer a unique opportunity to serve as mobile gateways for other more constrained devices with local connectivity. At the same time, they can gather context data about users and environment from the embedded sensors. These capabilities may be crucial for mobile M2M applications. Finally, in this paper, we consider a scenario where smartphones are used as gateways that collect and aggregate data from sensors in a cellular network. We conclude that, in order for their use to the feasible in terms of a normal depletion time of a smartphone’s battery, it is a good advice to maximize the collection of data necessary to be transmitted from nearby sensors, and maximize the intervals between transmissions. More research is required to devise energy efficient transmission methods that enable the use of smartphones as mobile gateways.

  5. Towards efficient mobile M2M communications: survey and open challenges.

    Science.gov (United States)

    Pereira, Carlos; Aguiar, Ana

    2014-10-20

    Machine-to-Machine (M2M) communications enable networked devices and services to exchange information and perform actions seamlessly without the need for human intervention. They are viewed as a key enabler of the Internet of Things (IoT) and ubiquitous applications, like mobile healthcare, telemetry, or intelligent transport systems. We survey existing work on mobile M2M communications, we identify open challenges that have a direct impact on performance and resource usage efficiency, especially the impact on energy efficiency, and we review techniques to improve communications. We review the ETSI standard and application protocols, and draw considerations on the impact of their use in constrained mobile devices. Nowadays, smartphones are equipped with a wide range of embedded sensors, with varied local and wide area connectivity capabilities, and thus they offer a unique opportunity to serve as mobile gateways for other more constrained devices with local connectivity. At the same time, they can gather context data about users and environment from the embedded sensors. These capabilities may be crucial for mobile M2M applications. Finally, in this paper, we consider a scenario where smartphones are used as gateways that collect and aggregate data from sensors in a cellular network. We conclude that, in order for their use to the feasible in terms of a normal depletion time of a smartphone's battery, it is a good advice to maximize the collection of data necessary to be transmitted from nearby sensors, and maximize the intervals between transmissions. More research is required to devise energy efficient transmission methods that enable the use of smartphones as mobile gateways.

  6. Dynamic analyses of electromagnetic force on ferritic board for AMTEX on JFT-2M

    Energy Technology Data Exchange (ETDEWEB)

    Urata, K. E-mail: uratak@fusion.naka.jaeri.go.jp; Suzuki, Y.; Kudough, F.; Kimura, H.; Miura, Y.; Yamamoto, M

    2001-10-01

    Covering the inside wall of the vacuum vessel with the ferritic boards (FBs) is planned in the third stage of the Advanced Material Tokamak Experiment (AMTEX) on JFT-2M. The total magnetic forces induced on FBs were calculated by the three-dimensional dynamic electromagnetic field analysis code, EMSolution, with solid magnetic elements to consider the coupled effects of eddy current and magnetization, and the skin effect of eddy current. The structural integrity was evaluated on the bolts fixing the FBs to the vacuum vessel.

  7. Dynamic analyses of electromagnetic force on ferritic board for AMTEX on JFT-2M

    International Nuclear Information System (INIS)

    Urata, K.; Suzuki, Y.; Kudough, F.; Kimura, H.; Miura, Y.; Yamamoto, M.

    2001-01-01

    Covering the inside wall of the vacuum vessel with the ferritic boards (FBs) is planned in the third stage of the Advanced Material Tokamak Experiment (AMTEX) on JFT-2M. The total magnetic forces induced on FBs were calculated by the three-dimensional dynamic electromagnetic field analysis code, EMSolution, with solid magnetic elements to consider the coupled effects of eddy current and magnetization, and the skin effect of eddy current. The structural integrity was evaluated on the bolts fixing the FBs to the vacuum vessel

  8. Design and analysis of 2T-2M Ternary content addressable memories

    KAUST Repository

    Bahloul, M. A.; Fouda, M. E.; Naous, Rawan; Zidan, Mohammed A.; Eltawil, A. M.; Kurdahi, F.; Salama, Khaled N.

    2017-01-01

    Associate and approximate computing using resistive memory based Ternary Content Addressable Memory is becoming widely used. In this paper, a simplified model based analysis of a 2T2M-Ternary Content Addressable Memory using memristors is introduced. A comprehensive study is presented taking into consideration different circuit parameters and parasitic effects. Parameters such as the memristor Rh/Rl ratio, transistor technology, operating frequency, and memory width are taken into consideration. The proposed model is verified with SPICE showing a high degree of matching between theory and simulation. The utility of the model is established using a design example.

  9. Verification study of the FORE-2M nuclear/thermal-hydraulilc analysis computer code

    International Nuclear Information System (INIS)

    Coffield, R.D.; Tang, Y.S.; Markley, R.A.

    1982-01-01

    The verification of the LMFBR core transient performance code, FORE-2M, was performed in two steps. Different components of the computation (individual models) were verified by comparing with analytical solutions and with results obtained from other conventionally accepted computer codes (e.g., TRUMP, LIFE, etc.). For verification of the integral computation method of the code, experimental data in TREAT, SEFOR and natural circulation experiments in EBR-II were compared with the code calculations. Good agreement was obtained for both of these steps. Confirmation of the code verification for undercooling transients is provided by comparisons with the recent FFTF natural circulation experiments. (orig.)

  10. Radiofrequency experiments in JFT-2M: Demonstration of innovative applications of a travelling wave antenna

    International Nuclear Information System (INIS)

    Ogawa, T.; Hoshino, K.; Kanazawa, S.

    2001-01-01

    Several innovative applications of a travelling wave (combline) antenna designed for fast wave current drive have been demonstrated for the first time in the JFT-2M tokamak. High energy electrons of at least 10 keV were produced in the plasma core by highly directional fast waves in electron cyclotron heated plasmas. The ponderomotive potential of the beat wave, produced by fast waves at two different frequencies, was directly measured for the first time by a heavy ion beam probe. Plasma production was demonstrated using the wave fields excited by the combline antenna over a wide range of toroidal magnetic fields (0.5-2.2 T). (author)

  11. Illumination technique for the relative calibration of the ASTRI SST-2M camera

    International Nuclear Information System (INIS)

    Rodeghiero, Gabriele; Catalano, Osvaldo; Segreto, Alberto; De Caprio, Vincenzo; Giro, Enrico; Lessio, Luigi; Conconi, Paolo; Canestrari, Rodolfo

    2014-01-01

    We present a new illumination technique for the camera relative gain calibration of the ASTRI SST-2M Cherenkov telescope. The camera illumination is achieved by means of an optical fiber that diffuses the light inside a protective PMMA window above the focal plane. We report the encouraging results of the development tests carried out on two PMMA window prototypes illuminated by a standard optical fiber. We checked also the reliability of the method by a series of ray tracing simulations for different scattering models and PMMA window shapes finding good agreement with experimental results

  12. Illumination technique for the relative calibration of the ASTRI SST-2M camera

    Energy Technology Data Exchange (ETDEWEB)

    Rodeghiero, Gabriele, E-mail: gabriele.rodeghiero@studenti.unipd.it [Department of Physics and Astronomy, University of Padova, Vicolo dell' Osservatorio 5, 35100 PD (Italy); Catalano, Osvaldo; Segreto, Alberto [INAF IASF Palermo, Via Ugo La Malfa 153, 90146 PA (Italy); De Caprio, Vincenzo [INAF OACN, Salita Moiariello, 16, 80131 Napoli, NA (Italy); Giro, Enrico; Lessio, Luigi [INAF OAPD, Vicolo dell' Osservatorio 5, 35100 PD (Italy); Conconi, Paolo; Canestrari, Rodolfo [INAF OAB, Via E. Bianchi 46, 23807 Merate, LC (Italy)

    2014-11-11

    We present a new illumination technique for the camera relative gain calibration of the ASTRI SST-2M Cherenkov telescope. The camera illumination is achieved by means of an optical fiber that diffuses the light inside a protective PMMA window above the focal plane. We report the encouraging results of the development tests carried out on two PMMA window prototypes illuminated by a standard optical fiber. We checked also the reliability of the method by a series of ray tracing simulations for different scattering models and PMMA window shapes finding good agreement with experimental results.

  13. Design and analysis of 2T-2M Ternary content addressable memories

    KAUST Repository

    Bahloul, M. A.

    2017-10-24

    Associate and approximate computing using resistive memory based Ternary Content Addressable Memory is becoming widely used. In this paper, a simplified model based analysis of a 2T2M-Ternary Content Addressable Memory using memristors is introduced. A comprehensive study is presented taking into consideration different circuit parameters and parasitic effects. Parameters such as the memristor Rh/Rl ratio, transistor technology, operating frequency, and memory width are taken into consideration. The proposed model is verified with SPICE showing a high degree of matching between theory and simulation. The utility of the model is established using a design example.

  14. Ion heat pulse after sawtooth crash in the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Miura, Y.; Okano, F.; Suzuki, N.; Mori, M.; Hoshino, K.; Maeda, H.; Takizuka, T.; Itoh, K.; Itoh, S.

    1993-08-01

    The ion heat pulse after sawtooth crash is studied with the time-of-flight neutral measurement on the JFT-2M tokamak. The rapid change of the bulk ion energy distribution near the edge is observed after sawtooth crash. The delay time is measured and the effective measuring position is estimated by a neutral transport code, then the thermal conductivity, χ i HP , of about 15±10m 2 /sec is evaluated for the L-mode plasma. The simple diffusive model with constant χ i HP , however, does not explain the amplitude of the pulse in the ion energy distribution. (author)

  15. EERE-VTO T2M Project Final Report - Ideation of a Novel Commercialization Model

    Energy Technology Data Exchange (ETDEWEB)

    Chamberlain, Jeffrey P. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-05-03

    The Department of Energy Technology Transfer mission is to expand the commercial impact of DOE's portfolio of R&D activities, providing ongoing economic, security, and environmental benefits for all Americans. To advance this mission, Argonne National Laboratory has executed this Technology-to-Market (T2M) project funded by EERE-VTO. The objective of the project was to ideate an overall business model for a private entity with a mission to develop and deploy technology by identifying, de-risking, and moving scientific advances into commercial use.

  16. The europium and praseodymium hydrolysis in a 2M NaCl environment

    International Nuclear Information System (INIS)

    Jimenez R, M.; Lopez G, H.; Solache R, M.; Rojas H, A.

    1998-01-01

    It was studied the europium and praseodymium hydrolysis in a 2M NaCl ion force environment at 303 K, through two methods: this one extraction with dissolvents (lanthanide-water-NaCl-dibenzoylmethane) in presence of a competitive ligand (diglycolic acid) and that one direct potentiometric titration, of soluble species, followed by a computer refining. The values of one or another techniques of the first hydrolysis constants obtained were similar, which demonstrates that the results are reliable. The set of data obtained on the stability constants of hydrolysis products allowed to draw up the distribution diagrams of chemical species, as europium as praseodymium in aqueous environment. (Author)

  17. Vacuum component subsystem of TV Thomson scattering system in JFT-2M

    International Nuclear Information System (INIS)

    Shiina, Tomio; Yamauchi, Toshihiko; Fujisawa, Atsushi; Hanawa, Osamu; Dimock, D.; Takahashi, Akira; Inomata, Shinji.

    1991-03-01

    The vacuum component subsystem, which is one of six subsystems in TV Thomson scattering (TVTS) system for the JFT-2M tokamak, is completed under a US-JAPAN cooperative program. This subsystem is composed of top and bottom flanges, side flange, beam dump, viewing dump and so on. These components are fitted in the existing 13-point Thomson scattering system as well as the TVTS optics newly developed by Princeton Plasma Physics Laboratory (PPPL) in USA. New feedback system of laser beam alignment was designed and developed. (author)

  18. Technical development and operation of TV thomson scattering system on JFT-2M tokamak

    International Nuclear Information System (INIS)

    Shiina, Tomio; Yamauchi, Toshihiko; Ishige, Yoichi

    1998-10-01

    Six years have passed since the TV Thomson scattering system (TVTS) was completed and the operation was started on the JFT-2M tokamak. TVTS was developed in collaboration with Princeton Plasma Physics Laboratory. Many troubles on the hardware are and the software are were encountered. Improvements of the system were needed in each occasion. Phenomena of troubles were carefully analyzed and they have been solved in operating the system. This paper presents thus obtained know-how necessary for the operation of TVTS as well as methods of operation. (author)

  19. A compact dilution refrigerator with vertical heat exchangers for operation to 2 mK

    International Nuclear Information System (INIS)

    Bunkov, Yu.M.; Guenault, A.M.; Hayward, D.J.; Jackson, D.A.; Kennedy, C.J.; Nichols, T.R.; Miller, I.E.; Pickett, G.R.; Ward, M.G.

    1991-01-01

    A compactly designed dilution refrigerator with closely packed, vertical heat exchangers is described. The refrigerator reaches a temperature of 2 mK and is easily constructed, since the sintered heat exchangers are straight units. Vibrating wire resonators are employed in the mixing chamber as diagnostic tools, which may act as both thermometers and phase-boundary level indicators. There is a design problem in the vertical arrangement, namely, the sumps on the concentrated phase side that can slowly fill with dilute phase and degrade the performance. The problem is solved by draining the superfluid 4 He component in any collected dilute phase through superleaks into the mixing chamber

  20. Study of the Polarization Strategy for Electron Cyclotron Heating Systems on HL-2M

    Science.gov (United States)

    Zhang, F.; Huang, M.; Xia, D. H.; Song, S. D.; Wang, J. Q.; Huang, B.; Wang, H.

    2016-06-01

    As important components integrated in transmission lines of electron cyclotron heating systems, polarizers are mainly used to obtain the desired polarization for highly efficient coupling between electron cyclotron waves and plasma. The polarization strategy for 105-GHz electron cyclotron heating systems of HL-2M tokamak is studied in this paper. Considering the polarizers need high efficiency, stability, and low loss to realize any polarization states, two sinusoidal-grooved polarizers, which include a linear polarizer and an elliptical polarizer, are designed with the coordinate transformation method. The parameters, the period p and the depth d, of two sinusoidal-grooved polarizers are optimized by a phase difference analysis method to achieve an almost arbitrary polarization. Finally, the optimized polarizers are manufactured and their polarization characteristics are tested with a low-power test platform. The experimental results agree well with the numerical calculations, indicating that the designed polarizers can meet the polarization requirements of the electron cyclotron heating systems of HL-2M tokamak.

  1. 1x2M steel performance in the BOR-60 steam generator

    International Nuclear Information System (INIS)

    Golovanov, V.N.; Shamardin, V.K.; Kondratiev, V.I.; Kryukov, F.N.; Chernobrovkin, Yu.V.; Bulanova, T.M.; Bai, V.F.

    The results from studies of 1x2M steel characteristics are presented. This steel was used as the material for the BOR-60 steam generator that had been in operation under the steam generating mode for 18,000 hs (35,000 hs in sodium). It was revealed that the pit corrosion depth on the water/steam side evaporative tube surfaces was about 0.25 μm and less and the total corrosion rate was less than 0.06 mm/y. The mechanical properties of the material were essentially similar both in the evaporator and superheater and met all the requirements imposed on. Based on the analysis of data on the decarbonizaton depth in sodium and on the corrosion damage in water and steam it was concluded that 1x2M steel can be successfully used as the steam generator material at the operating temperatures up to 470 deg. C and had sufficiently longer service-life as compared to 18,000 hs. (author)

  2. Development and evaluation of intelligent machine tools based on knowledge evolution in M2M environment

    International Nuclear Information System (INIS)

    Kim, Dong Hoon; Song, Jun Yeob; Lee, Jong Hyun; Cha, Suk Keun

    2009-01-01

    In the near future, the foreseen improvement in machine tools will be in the form of a knowledge evolution-based intelligent device. The goal of this study is to develop intelligent machine tools having knowledge-evolution capability in Machine to Machine (M2M) wired and wireless environment. The knowledge evolution-based intelligent machine tools are expected to be capable of gathering knowledge autonomously, producing knowledge, understanding knowledge, applying reasoning to knowledge, making new decisions, dialoguing with other machines, etc. The concept of the knowledge-evolution intelligent machine originated from the process of machine control operation by the sense, dialogue and decision of a human expert. The structure of knowledge evolution in M2M and the scheme for a dialogue agent among agent-based modules such as a sensory agent, a dialogue agent and an expert system (decision support agent) are presented in this paper, and work-offset compensation from thermal change and recommendation of cutting condition are performed on-line for knowledge-evolution verification

  3. Reprogramming the Dynamin 2 mRNA by Spliceosome-mediated RNA Trans-splicing

    Directory of Open Access Journals (Sweden)

    Delphine Trochet

    2016-01-01

    Full Text Available Dynamin 2 (DNM2 is a large GTPase, ubiquitously expressed, involved in membrane trafficking and regulation of actin and microtubule cytoskeletons. DNM2 mutations cause autosomal dominant centronuclear myopathy which is a rare congenital myopathy characterized by skeletal muscle weakness and histopathological features including nuclear centralization in absence of regeneration. No curative treatment is currently available for the DNM2-related autosomal dominant centronuclear myopathy. In order to develop therapeutic strategy, we evaluated here the potential of Spliceosome-Mediated RNA Trans-splicing technology to reprogram the Dnm2-mRNA in vitro and in vivo in mice. We show that classical 3′-trans-splicing strategy cannot be considered as accurate therapeutic strategy regarding toxicity of the pre-trans-splicing molecules leading to low rate of trans-splicing in vivo. Thus, we tested alternative strategies devoted to prevent this toxicity and enhance frequency of trans-splicing events. We succeeded to overcome the toxicity through a 5′-trans-splicing strategy which also allows detection of trans-splicing events at mRNA and protein levels in vitro and in vivo. These results suggest that the Spliceosome-Mediated RNA Trans-splicing strategy may be used to reprogram mutated Dnm2-mRNA but highlight the potential toxicity linked to the molecular tools which have to be carefully investigated during preclinical development.

  4. Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage

    Directory of Open Access Journals (Sweden)

    Hurng-Wern Huang

    2018-04-01

    Full Text Available The natural compound sinularin, isolated from marine soft corals, is antiproliferative against several cancers, but its possible selective killing effect has rarely been investigated. This study investigates the selective killing potential and mechanisms of sinularin-treated breast cancer cells. In 3-(4,5-dimethylthiazol-2-yl-5-(3-carboxymethoxyphenyl-2-(4-sulfophenyl-2H- tetrazolium, inner salt (MTS assay, sinularin dose-responsively decreased the cell viability of two breast cancer (SKBR3 and MDA-MB-231 cells, but showed less effect on breast normal (M10 cells after a 24 h treatment. According to 7-aminoactinomycin D (7AAD flow cytometry, sinularin dose-responsively induced the G2/M cycle arrest of SKBR3 cells. Sinularin dose-responsively induced apoptosis on SKBR3 cells in terms of a flow cytometry-based annexin V/7AAD assay and pancaspase activity, as well as Western blotting for cleaved forms of poly(ADP-ribose polymerase (PARP, caspases 3, 8, and 9. These caspases and PARP activations were suppressed by N-acetylcysteine (NAC pretreatment. Moreover, sinularin dose-responsively induced oxidative stress and DNA damage according to flow cytometry analyses of reactive oxygen species (ROS, mitochondrial membrane potential (MitoMP, mitochondrial superoxide, and 8-oxo-2′-deoxyguanosine (8-oxodG. In conclusion, sinularin induces selective killing, G2/M arrest, apoptosis, and oxidative DNA damage of breast cancer cells.

  5. Effects of the second X-point on hot VDE in HL-2M

    Science.gov (United States)

    Xue, L.; Duan, X. R.; Zheng, G. Y.; Liu, Y. Q.; Dokuka, V. N.; Lukash, V. E.; Khayrutdinov, R. R.

    2017-05-01

    Study of the hot-plasma vertical displacement event (VDE) in advanced divertor configurations is of significant importance for ITER and for future fusion reactors. The newly designed, medium-sized copper-conductor machine HL-2M has the capability of generating the second X-point for various advanced divertor configurations. In this paper, effects of the second X-point on the hot VDE in HL-2M are numerically investigated by utilizing the non-linear time-dependent DINA code. The simulation results show that the existence of the second X-point at certain special locations appears to have a better stability in the vertical direction, compared to the standard configuration with the same main plasma parameters. Meanwhile, the peak halo current during the current quench tends to increase as the second X-point changes in the horizontal direction. The same quantity decreases as the second X-point changes in the vertical direction away from the dominant X-point. From the view point of minimizing the halo current, the tripod is better than the standard configuration, followed by the snowflake-plus and the exact snowflake (SF) configuration. The SF-minus is the worst scenario. On the other hand, the tripod configuration, as well as the SF minus configurations, results in relatively higher peak electromagnetic force acting on the vacuum vessel, when compared to other aforementioned configurations.

  6. ISOMP: An Instant Service-Orchestration Mobile M2M Platform

    Directory of Open Access Journals (Sweden)

    Cholhong Im

    2016-01-01

    Full Text Available Smartphones have greater computing power than ever before, providing convenient applications to improve our lives. In general, people find it difficult to locate suitable applications and implementing new applications often requires professional skills. In this paper, we propose a new service platform that facilitates the implementation of new applications by composing prebuilt components that provide the context information of mobile devices such as location and contacts. Our platform introduces an innovative concept named context collaboration, in which smartphones exchange context information with each other, which in turn is used to deduct useful inferences. The concept is realized by instant orchestration, which assembles some components and implements a composite component. The interactive communication interface helps a mobile device to communicate with other devices using open APIs, such as SOAP and HTTP (REST. The platform also works in heterogeneous environments, for example, between Android and iOS operating systems. Throughout the platform, mobile devices can act as smart M2M machines with context awareness, enabling intelligent tasks on behalf of users. Our platform will open up a new and innovative pathway for both enhanced mobile context awareness and M2M, which is expected to be a fundamental feature of the next generation of mobile devices.

  7. Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells.

    Science.gov (United States)

    Chang, Hsin-Yi; Shih, Meng-Her; Huang, Hsuan-Cheng; Tsai, Shang-Ru; Juan, Hsueh-Fen; Lee, Si-Chen

    2013-01-01

    There were studies investigating the effects of broadband infrared radiation (IR) on cancer cell, while the influences of middle-infrared radiation (MIR) are still unknown. In this study, a MIR emitter with emission wavelength band in the 3-5 µm region was developed to irradiate A549 lung adenocarcinoma cells. It was found that MIR exposure inhibited cell proliferation and induced morphological changes by altering the cellular distribution of cytoskeletal components. Using quantitative PCR, we found that MIR promoted the expression levels of ATM (ataxia telangiectasia mutated), ATR (ataxia-telangiectasia and Rad3-related and Rad3-related), TP53 (tumor protein p53), p21 (CDKN1A, cyclin-dependent kinase inhibitor 1A) and GADD45 (growth arrest and DNA-damage inducible), but decreased the expression levels of cyclin B coding genes, CCNB1 and CCNB2, as well as CDK1 (Cyclin-dependent kinase 1). The reduction of protein expression levels of CDC25C, cyclin B1 and the phosphorylation of CDK1 at Thr-161 altogether suggest G(2)/M arrest occurred in A549 cells by MIR. DNA repair foci formation of DNA double-strand breaks (DSB) marker γ-H2AX and sensor 53BP1 was induced by MIR treatment, it implies the MIR induced G(2)/M cell cycle arrest resulted from DSB. This study illustrates a potential role for the use of MIR in lung cancer therapy by initiating DSB and blocking cell cycle progression.

  8. HERSCHEL/HIFI OBSERVATIONS OF HYDROGEN FLUORIDE TOWARD SAGITTARIUS B2(M)

    International Nuclear Information System (INIS)

    Monje, R. R.; Emprechtinger, M.; Phillips, T. G.; Lis, D. C.; Goldsmith, P. F.; Bergin, E. A.; Bell, T. A.; Neufeld, D. A.; Sonnentrucker, P.

    2011-01-01

    Herschel/HIFI observations have revealed the presence of widespread absorption by hydrogen fluoride (HF) J = 1-0 rotational transition, toward a number of Galactic sources. We present observations of HF J = 1-0 toward the high-mass star-forming region Sagittarius B2(M). The spectrum obtained shows a complex pattern of absorption, with numerous features covering a wide range of local standard of rest velocities (-130 to 100 km -1 ). An analysis of this absorption yields HF abundances relative to H 2 of ∼1.3 x 10 -8 , in most velocity intervals. This result is in good agreement with estimates from chemical models, which predict that HF should be the main reservoir of gas-phase fluorine under a wide variety of interstellar conditions. Interestingly, we also find velocity intervals in which the HF spectrum shows strong absorption features that are not present, or are very weak, in spectra of other molecules, such as 13 CO (1-0) and CS (2-1). HF absorption reveals components of diffuse clouds with small extinction that can be studied for the first time. Another interesting observation is that water is significantly more abundant than hydrogen fluoride over a wide range of velocities toward Sagittarius B2(M), in contrast to the remarkably constant H 2 O/HF abundance ratio with average value close to unity measured toward other Galactic sources.

  9. The interaction of beta 2-microglobulin (beta 2m) with mouse class I major histocompatibility antigens and its ability to support peptide binding. A comparison of human and mouse beta 2m

    DEFF Research Database (Denmark)

    Pedersen, L O; Stryhn, A; Holter, T L

    1995-01-01

    of class I molecules are involved in peptide binding, whereas most of class I molecules are involved in beta 2m binding. We propose that mouse beta 2m interacts with the minor peptide binding (i.e. the "empty") fraction with a lower affinity than human beta 2m does, whereas mouse and human beta 2m interact......The function of major histocompatibility complex (MHC) class I molecules is to sample peptides derived from intracellular proteins and to present these peptides to CD8+ cytotoxic T lymphocytes. In this paper, biochemical assays addressing MHC class I binding of both peptide and beta 2-microglobulin...... (beta 2m) have been used to examine the assembly of the trimolecular MHC class I/beta 2m/peptide complex. Recombinant human beta 2m and mouse beta 2ma have been generated to compare the binding of the two beta 2m to mouse class I. It is frequently assumed that human beta 2m binds to mouse class I heavy...

  10. Clinical significance of determination of serum and urine β2-microglobulin (β2-m) in patients with Graves' disease

    International Nuclear Information System (INIS)

    Wang Luhua; Mai Mang; Ouyang Xiaoqing; Wang Shuhua; Lin Cen; Fang Linli

    2005-01-01

    Objective: To explore the relationship between the serum, urine contents of β 2 -m and serum thyroid hormones levels in patients with Graves' disease. Methods: Serum, urine β 2 -m contents (with RIA), serum FT 3 , FT 4 levels (with CLIA), TGA, TMA positive rates (with RIA) were determined in 82 patients with Graves' disease both before and after treatment as well as in 40 controls. Results: The serum and urine β 2 -m contents as well as the serum FT 3 , FT 4 levels in the 82 hyperthyroid patients before treatment were significantly higher than those in the controls (P 2 -m, FT 3 , FT 4 levels dropped to approaching normal (vs controls, P>0.05). In the 13 treatment failures, the levels remained significantly higher than those in controls (P 2 -m contents after treatment paralleled those of FT 3 , FT 4 levels. β 2 -m could be used as a diagnostic indicator for hyperthyroidism. (authors)

  11. High Beta Steady State Research and Future Directions on JT-60U and JFT-2M

    Science.gov (United States)

    Ishida, Shinichi

    2003-10-01

    JT-60U and JFT-2M research is focused on high beta steady state operation towards economically and environmentally attractive reactors. In JT-60U, a high-βp H-mode plasma was sustained with βN 2.7 for 7.4 s in which neoclassical tearing modes (NTMs) limited the attainable β_N. Real-time tracking NTM stabilization system using ECCD demonstrated complete suppression of NTM leading to recovery of βN before onset of NTM. Performance in a fully non-inductive H-mode plasma was improved up to n_i(0) τE T_i(0) = 3.1 x 10^20 keV s m-3 using N-NBCD with βN 2.4, HH_y,2=1.2 and bootstrap fraction f_BS 0.5. ECH experiments extended the confinement enhancement for dominantly electron heated reversed shear plasmas up to HH_y,2 2 at T_e/Ti 1.25. A world record ECCD efficiency, 4.2 x 10^18 A/W/m^2, was achieved at Te 23 keV with a highly localized central current density. Innovative initiation and current build-up without center solenoid currents were established by LHCD/ECH and bootstrap current up to f_BS 0.9. In JFT-2M, the inside of the vacuum vessel wall was fully covered with low-activation ferritic steel plates to investigate their use in plasmas near fusion conditions. High βN plasmas were produced up to βN = 3.3 with an internal transport barrier (ITB) and a steady H-mode edge. A new H-mode regime with steady high recycling (HRS) and an ITB was exploited leading to βN H_89P 6.2 at n_e/nG 0.7. In 2003, JT-60U will be able to operate for the duration up to 65 s at 1 MA/2.7 T and the heating/current-drive duration up to 30 s at 17 MW to prolong high-βN and/or high-f_BS discharges with feedback controls. JFT-2M is planning to implement wall stabilization experiments in 2004 to pursue plasmas above the ideal no-wall limit using a ferritic wall. The modification of JT-60 to a fully superconducting tokamak is under discussion to explore high-β steady state operation in collision-less plasmas well above no-wall limit with ferritic wall in a steady state.

  12. Relación entre la fuerza máxima en squat y acciones de salto, sprint y golpeo de balón. (Relationship among maximal strength in squat exercise, jump, sprint and kicking ball performance.

    Directory of Open Access Journals (Sweden)

    Alfredo Arija Blázquez

    2008-01-01

    Full Text Available ResumenEl objetivo del presente estudio fue analizar las posibles relaciones entre la fuerza máxima en squat y accionesexplosivas de salto, sprint y golpeo de balón. Para ello, se contó con una muestra formada por estudiantes de Ciencias del Deporte (N= 16; 19,6 ± 1,7 años de sexo masculino (con escasa experiencia en el entrenamiento de fuerza, que llevaron a cabo un test de 1RM en squat (calculándose el peso levantado, la fuerza media total y la fuerza dinámica máxima, tests de salto vertical (SJ, CMJ y CMJa, un test de sprint de 20 m (con mediciones de tiempo cada 5 m, y un test de golpeo con el pie donde se calculaba la velocidad del balón. Se encontraron coeficientes de correlación moderados (entre 0,52 y 0,67 y significativos de las medidas de fuerza máxima y las alturas de salto, mientras que los coeficientes obtenidos entre los tiempos de sprint y dichas medidas de fuerza máxima se situaron entre -0,06 y -0,32, no siendo ninguno de ellos significativo; al igual que tampoco fueron significativos los coeficientes de correlación de las medidas de fuerza máxima y la velocidad de tiro, se situaron entre 0,25 y 0,34. Por tanto, la relación entre la fuerza máxima en squat y la altura de salto en sujetos con escasa experiencia en el entrenamiento de fuerza resultó moderada, mientras que no parece existir relación con el tiempo de sprint y la velocidad de tiro.AbstractThe purpose of the present study was to analyze the possible relationships between maximal strength insquat exercise and jump, sprint and kicking ball actions. Sixteen males sport science students (19,6 ± 1,7years, with little experience in strength training, performed a 1RM in squat exercise (from which liftedweight, the total average- and maximal-dynamic strength was assessed, vertical jump (SJ, CMJ and CMJa, a 20 m sprint test (with time measurement every 5 m, and a kicking ball test where the velocity of the ball was calculated. Moderate (0,52 - 0,67 and

  13. Efectos de diferentes intensidades relativas, volúmenes, tiempos de recuperación entre repeticiones y pérdida de velocidad en la serie sobre el rendimiento en sprint, salto vertical con cargas y sin cargas y la fuerza de las extremidades inferiores

    OpenAIRE

    Mora Custodio, Ricardo

    2017-01-01

    Programa de Doctorado en Ciencias de la Actividad Física y del Deporte En la presente tesis doctoral se llevaron a cabo cuatro estudios y tuvo como objetivo analizar los efectos producidos por diferentes configuraciones del entrenamiento de fuerza sobre el rendimiento en sprint, salto vertical y la fuerza máxima. En el Estudio I se analizó el efecto producido por dos programas de entrenamiento de fuerza equivalentes en todas sus variables excepto en la intensidad relativa (Cargas bajas 40...

  14. A cost-effective and serviceable ATLAST 9.2m telescope architecture

    Science.gov (United States)

    Feinberg, Lee D.; Jones, Andrew; Mosier, Gary; Rioux, Norman; Redding, Dave; Kienlen, Mike

    2014-08-01

    The ATLAST 9.2m architecture has evolved to be more cost effective while also meeting a more thorough understanding of the driving science requirements. The new approach can fit in an existing Delta IV Heavy rocket and makes extensive use of heritage and selective use of technology in order to minimize development time and cost. We have performed a more thorough look at how to meet the stability requirements for both thermal and dynamics and have an approach consistent with an initial error budget. In addition, we have developed concepts to support robotic or human servicing in a cost effective manner through a modular approach that relies on simple, external access and metrology. These refinements to the architecture enable a cost-effective, long-lifecycle, and relatively low risk approach to development.

  15. New development of JFT-2M Tokamak (3) data processing system

    International Nuclear Information System (INIS)

    Fukuchi, Y.; Oyabu, I.; Hirose, T.; Ichimura, H.; Inoue, K.; Komoto, Y.

    1986-01-01

    A data acquisition system for JFT-2M Tokamak is a computer complex system consisting of a CAMAC serial highway, a front-end computer, and a main computer, which are ranked in a definite hierarchical structure. This paper reports the data processing system by the main computer (using a super-mini-computer MELCOM 70/250) which is situated on the highest level in the data acquisition system and performs unified management and control over the system. The features of the data processing system by the main computer are as follows: (1) Expandability of the system based on the definite hierarchical structure; (2) Five-dimensional multi-processing (setup, acquisition, analysis, display, and storage); (3) Realization of RAS (Reliability, Availability, and Serviceability) function; and (4) Easy-to-use man-machine interface that provides: flexibility in CAMAC system configuration, open-ended interface and file history managing

  16. Optimization and calculation of the MCl-ZnCl2 (M = Li, Na, K) phase diagrams

    International Nuclear Information System (INIS)

    Romero-Serrano, Antonio; Hernandez-Ramirez, Aurelio; Cruz-Ramirez, Alejandro; Hallen-Lopez, Manuel; Zeifert, Beatriz

    2010-01-01

    An earlier structural model for binary silicate melts and glasses is extended to zinc chloride-alkali metal chloride systems. The evaluation of the available thermodynamic and phase diagrams data for the MCl-ZnCl 2 (M = Li, Na, K) binary systems have been carried out using the structural model for the liquid phase. This thermodynamic model is based on the assumption that each alkali chloride produces the depolymerization of ZnCl 2 network with a characteristic free-energy change. A least-squares optimization program permits all available thermodynamic and phase diagram data to be optimized simultaneously. In this manner, data for these binary systems have been analysed and represented with a small number of parameters.

  17. Design proposal for a JFT-2M TV Thomson scattering system

    International Nuclear Information System (INIS)

    Dimock, D.; Yamauchi, Toshihiko.

    1988-07-01

    A design for the optics of a TV Thomson scattering system for JFT-2M is presented, which will measure electron temperature and density profiles having up to 82 points, spanning the horizontal mid plane of the machine. A detailed design for the collecting optics is presented since it is critical to the success of the system. It is shown that the Bouwers type catadioptric collection optics can be color corrected allowing the system to be used over a wide wavelength range. The laser requirements are presented and are easily met with commercially available systems. Two sketches of spectrometer designs are presented for two different sizes of detector. The detector gating and readout requirements are presented and can be met in existing detector systems. The importance of developing larger area detectors is emphasized and a possible detector system is presented. (author)

  18. Improvement of the density limit with an external helical field on JFT-2M tokamak

    International Nuclear Information System (INIS)

    Tamai, H.; Shoji, T.; Nagashima, K.; Miura, Y.; Yamauchi, T.; Ogawa, H.; Kawashima, H.; Matsuda, T.; Mori, M.; Ida, K.; Ohdachi, S.

    1995-01-01

    The density limit is increased by the application of an external helical field in the JFT-2M tokamak. The effect of the magnetic stochasticity due to the external field is investigated to study the mechanism of the improved density limit related to the edge plasma behaviour. The improvement is correlated with the retardation of the increase in the plasma inductance. At the improved density limit, local radiation loss is modified by the helical field, in which that from the vicinity of separatrix X-point is remarkably reduced, while that from outboard edge is slightly increased. The formation of a positive radial electric field at the plasma edge is also observed in the presence of the helical field. ((orig.))

  19. Experimental estimations of the kinetics parameters of the IBR-2M reactor by stochastic noises

    International Nuclear Information System (INIS)

    Pepelyshev, Yu.N.; Tajybov, L.A.; Garibov, A.A.; Mekhtieva, R.N.

    2012-01-01

    Experimental investigations of stochastic fluctuations of pulse energy of the IBR-2M reactor have been carried out which allowed us to obtain some of the parameters of the reactor kinetics. At different levels of average power a sequence of values of pulse energy was recorded with the calculation of the distribution parameters. An ionization chamber with boron installed near the active zone was used as a neutron detector. The research results allowed us to estimate the average lifetime of prompt neutrons τ = (6.53±0.2)·10 -8 s, absolute power of the reactor and intensity of the source of spontaneous neutrons S sp ≤(6.72±0.12)·10 6 s -1 . It was shown that the experimental results are close to the calculated ones

  20. Simulation of Plasma Disruptions for HL-2M with the DINA Code

    International Nuclear Information System (INIS)

    Xue Lei; Duan Xu-Ru; Zheng Guo-Yao; Yan Shi-Lei; Liu Yue-Qiang; Dokuka, V. V.; Khayrutdinov, R. R.; Lukash, V. E.

    2015-01-01

    Plasma disruption is often an unavoidable aspect of tokamak operations. It may cause severe damage to in-vessel components such as the vacuum vessel conductors, the first wall and the divertor target plates. Two types of disruption, the hot-plasma vertical displacement event and the major disruption with a cold-plasma vertical displacement event, are simulated by the DINA code for HL-2M. The time evolutions of the plasma current, the halo current, the magnetic axis, the minor radius, the elongation as well as the electromagnetic force and eddy currents on the vacuum vessel during the thermal quench and the current quench are investigated. By comparing the electromagnetic forces before and after the disruption, we find that the disruption causes great damage to the vacuum vessel conductors. In addition, the hot-plasma vertical displacement event is more dangerous than the major disruption with the cold-plasma vertical displacement event. (paper)

  1. Karatsuba-Ofman Multiplier with Integrated Modular Reduction for GF(2m

    Directory of Open Access Journals (Sweden)

    CUEVAS-FARFAN, E.

    2013-05-01

    Full Text Available In this paper a novel GF(2m multiplier based on Karatsuba-Ofman Algorithm is presented. A binary field multiplication in polynomial basis is typically viewed as a two steps process, a polynomial multiplication followed by a modular reduction step. This research proposes a modification to the original Karatsuba-Ofman Algorithm in order to integrate the modular reduction inside the polynomial multiplication step. Modular reduction is achieved by using parallel linear feedback registers. The new algorithm is described in detail and results from a hardware implementation on FPGA technology are discussed. The hardware architecture is described in VHDL and synthesized for a Virtex-6 device. Although the proposed field multiplier can be implemented for arbitrary finite fields, the targeted finite fields are recommended for Elliptic Curve Cryptography. Comparing other KOA multipliers, our proposed multiplier uses 36% less area resources and improves the maximum delay in 10%.

  2. Early GRB optical and infrared afterglow observations with the 2-m robotic Liverpool Telescope

    International Nuclear Information System (INIS)

    Gomboc, A.; Ljubljana Univ., Ljubljana; Mundell, C.G.; Guidorzi, C.

    2005-01-01

    We present the first optical observations of a Gamma Ray Burst IGRB) afterglow using the 2-m robotic Liverpool Telescope (LT), which is owned and operated by Liverpool John Moores University and situated on La Palma. We briefly discuss the capabilities of LT and its suitability for rapid follow-up observations of early optical and infrared GRB light curves. In particular, the combination of aperture, site, instrumentation and rapid response (robotic over-ride mode aided by telescope's rapid slew and fully-opening enclosure) makes the LT ideal for investigating the nature of short bursts, optically-dark bursts, and GRB blast-wave physics in general. We briefly describe the LT's key position in the RoboNet-1.0 network of robotic telescopes. We present the LT observations of GRB041006 and use its gamma-ray properties to predict the time of the break in optical light curve, a prediction consistent with the observations

  3. Divertor plasma modification by divertor biasing and edge ergodization in JFT-2M

    International Nuclear Information System (INIS)

    Shoji, T.; Nagashima, K.; Tamai, H.; Ohdachi, S.; Miura, Y.; Ohasa, K.; Maeda, H.; Ohyabu, N.; Leonard, A.W.; Aikawa, H.; Fujita, T.; Hoshino, K.; Kawashima, H.; Matsuda, T.; Maeno, M.; Mori, M.; Ogawa, H.; Shimada, M.; Uehara, K.; Yamauchi, T.

    1995-01-01

    The effects of divertor biasing and edge ergodization on the divertor plasma have been investigated in the JFT-2M tokamak. Experimental results show; (1) The differential divertor biasing can change the in/out asymmetry of the divertor plasma. It especially changes the density on the ion side divertor plasma. The in/out electron pressure difference has a good correlation with the biasing current. (2) The unipolar divertor biasing can change the density profile of divertor plasma. The radial electric field and shear flow are the cause for this change. (3) The electron temperature of the divertor plasma in the H-mode with frequent ELMs induced by edge ergodization is lower than that of usual H-mode. That is due to the enhancement of the radial particle flux by frequent ELMs, ((orig.))

  4. Carrier Current Line Systems Technologies in M2M Architecture for Wireless Communication

    Directory of Open Access Journals (Sweden)

    Hua-Ching Chen

    2016-01-01

    Full Text Available This paper investigates the Carrier Current Line Systems (CCLS technologies of Machine to Machine (M2M architecture which applied for mobile station coverage working with metro, high speed railway, and subway such as analysis for public transport of an indoor transition system. It is based on the theory and practical engineering principle which provide guidelines and formulas for link budget design to help designers fully control and analyze the single output power of uplink and downlink between Fiber Repeaters (FR and mobile station as well as base station. Finally, the results of this leakage cable system are successfully applied to indoor coverage design for metro rapid transit system which are easily installed cellular over fiber solutions for WCDMA/LTE access is becoming Ubiquitous Network to Internet of Thing (IOT real case hierarchy of telecommunication.

  5. Design and development of the 2m resolution camera for ROCSAT-2

    Science.gov (United States)

    Uguen, Gilbert; Luquet, Philippe; Chassat, François

    2017-11-01

    EADS-Astrium has recently completed the development of a 2m-resolution camera, so-called RSI (Remote Sensing Instrument), for the small-satellite ROCSAT-2, which is the second component of the long-term space program of the Republic of China. The National Space Program Office of Taïwan selected EADS-Astrium as the Prime Contractor for the development of the spacecraft, including the bus and the main instrument RSI. The main challenges for the RSI development were: - to introduce innovative technologies in order to meet the high performance requirements while achieving the design simplicity necessary for the mission (low mass, low power) - to have a development approach and verification compatible with the very tight development schedule This paper describes the instrument design together with the development and verification logic that were implemented to successfully meet these objectives.

  6. Effect of closed shells on the multipole mixing parameter δ(E2/M1)

    International Nuclear Information System (INIS)

    Morozov, V.A.

    1992-01-01

    The behavior of the magnitude and sign of the mixing parameter δ(E2/M1) in even-even nuclei has been studied in a number of papers. The most extensive data has been given for transitions of the type 3 γ + , 2 γ + , 2 β + →2 g + . The data on δ are relatively scarce for mixed transitions in odd nuclei with magic or semimagic cores. However, certain conclusions can be drawn about the behavior of δ in transitions in odd nuclei near magic numbers, and also in transitions in even-even nuclei when passing through quasishells: (1) the absolute value of the reduced mixing parameter in transitions between particle and cluster-vibrational states in odd nuclei decreases as a closed shell is approached; (2) δ has the same sign for transitions between particle and cluster-vibrational levels in nuclei with Z=83 and 85 and N=83, 85, and 87; (3) in odd nuclei the sign of δ is positive for transitions between positive-parity states s 1/2 -d 3/2 in Cd, Sm, and Tl isotopes and is negative for transitions between negative-parity states f 7/2 π and h 9/2 π in Sm, Gd, Bi, and At isotopes, independently of whether these transitions are neutron or proton transitions; (4) the removal of ±2 nucleons in an even shell from a magic core (and in certain nuclei a larger number of pairs of nucleons) does not lead to a change in sign of δ in transitions producing an odd nucleus; (5) the closure of quasishells at N=96 and 104 in even-even nuclei is associated with an increase in the absolute value of δ(E2/M1)/E γ , but the sign of δ does not change

  7. Chromosomal instability and the abrogated G2/M arrest in x-irradiated myelodysplastic syndrome cells

    International Nuclear Information System (INIS)

    Ban, S.; Sudo, H.; Saegusa, K.; Sagara, M.; Imai, T.; Kimura, A.

    2003-01-01

    A preliminary epidemiological study demonstrated that myelodysplastic syndrome (MDS) has an excess relative risk per sievert of 13 in atomic bomb survivors in Hiroshima. MDS is the only other radiogenic blood disease apart from leukemia. Clinically, MDS involves dysplastic hematopoiesis and an increased risk of leukemic transformation. Because it is uncertain whether MDS pathogenesis affects lymphoid progenitor cells as well as myeloid progenitor cells, we investigated the karyotypes of bone marrow cells and the micronucleus (MN) frequency in peripheral T lymphocytes of twenty- three atomic bomb survivors with MDS and five normal individuals. Aneuploidy was observed in 10 of 23 patients. Chromosome aberrations were observed in 3 of 12 patients with mild symptoms, and six of 11 patients of severe symptoms. The spontaneous- and X-ray-induced-MN frequencies were significantly higher in MDS patients than in normal individuals. Interestingly, radiation sensitivity increased along with the severity of MDS clinical subtypes. Because many of the patients in this study had not been exposed to chemo- or radiation- therapy, their unusual radiosensitivity may be related to their chromosomal or genomic instability. Immortalized lymphoid cell lines were established from B-lymphocytes infected with Epstein-Barr virus in vitro. The abrogation of radiation-induced-G2/M arrest was observed in 10 of 12 MDS-B lymphoid cell lines, but not in the normal B lymphoid cell lines. Our data suggest that the control of chromosomal stability is impaired in pluripotent stem cells of MDS patients, and that the abrogated G2/M arrest may be involved in the pathophysiology of disease progression and the high radiation sensitivity of patients

  8. Single-layer ZnMN2 (M = Si, Ge, Sn) zinc nitrides as promising photocatalysts.

    Science.gov (United States)

    Bai, Yujie; Luo, Gaixia; Meng, Lijuan; Zhang, Qinfang; Xu, Ning; Zhang, Haiyang; Wu, Xiuqiang; Kong, Fanjie; Wang, Baolin

    2018-05-30

    Searching for two-dimensional semiconductor materials that are suitable for visible-light photocatalytic water splitting provides a sustainable solution to deal with the future energy crisis and environmental problems. Herein, based on first-principles calculations, single-layer ZnMN2 (M = Si, Ge, Sn) zinc nitrides are proposed as efficient photocatalysts for water splitting. Stability analyses show that the single-layer ZnMN2 zinc nitrides exhibit energetic and dynamical stability. The electronic properties reveal that all of the single-layer ZnMN2 zinc nitrides are semiconductors. Interestingly, single-layer ZnSnN2 is a direct band gap semiconductor with a desirable band gap (1.74 eV), and the optical adsorption spectrum confirms its optical absorption in the visible light region. The hydrogen evolution reaction (HER) calculations show that the catalytic activity for single-layer ZnMN2 (M = Ge, Sn) is better than that of single-layer ZnSiN2. Furthermore, the band gaps and band edge positions for the single-layer ZnMN2 zinc nitrides can be effectively tuned by biaxial strain. Especially, single-layer ZnGeN2 can be effectively tuned to match better with the redox potentials of water and enhance the light absorption in the visible light region at a tensile strain of 5%, which is confirmed by the corresponding optical absorption spectrum. Our results provide guidance for experimental synthesis efforts and future searches for single-layer materials suitable for photocatalytic water splitting.

  9. Desarrollo de un Banco de Pruebas Experimental mediante Control de Fuerza con Robot Industrial para el Análisis de la Respuesta Mecánica de Asientos de Coche

    Directory of Open Access Journals (Sweden)

    A. Valera

    2009-04-01

    Full Text Available Resumen: Este trabajo presenta el desarrollo de un banco de pruebas experimental para el análisis de la respuesta mecánica de los asientos de vehículos durante la entrada y salida de pasajeros. Para realizar este desarrollo, se consideran dos fases: la primera fase es la captura de datos, realizada mediante una manta sensorizada con una red de galgas de presión y un sistema de fotogrametría a fin de capturar el movimiento realizado por una persona al sentarse en el asiento de un automóvil. La segunda fase consiste en reproducir dicho movimiento de forma automática mediante un maniquí acoplado a un robot, controlando la fuerza que ejerce el maniquí sobre el asiento.El desarrollo debe permitir aplicar diferentes estrategias de control de fuerza con robots industriales, utilizando para ello una plataforma de prueba consistente en el robot IRB140 de ABB y un sensor de fuerza industrial JR3 de 6 grados de libertad. Como arquitectura de control, se presentan dos alternativas. La primera utiliza la aplicación software WebWare SDK de ABB. En la segunda solución, se ha modificado el controlador original S4CPlus del robot, proporcionando una arquitectura abierta de control que permite la implementación de nuevos algoritmos de control de movimiento y fuerza en el robot industrial.Con esta aplicación, se simula el proceso realizado por una persona al sentarse y levantarse del asiento de un automóvil, monitorizándose y controlándose la fuerza que ejerce un maniquí sobre un asiento para garantizar igualdad de condiciones con el caso real. El sistema desarrollado tiene numerosas aplicaciones prácticas, como por ejemplo la de poder analizar el desgaste que estos movimientos ocasionan en la tapicería de los asientos. Palabras clave: control de fuerza, control de robots, simulación de movimientos humanos, control por computador, aplicaciones digitales de computación, robots manipuladores

  10. EFECTO DEL ENTRENAMIENTO INTEGRADO SOBRE LA MEJORA DE LA FUERZA DE IMPULSIÓN EN UN LANZAMIENTO EN SUSPENSIÓN EN BALONMANO

    Directory of Open Access Journals (Sweden)

    P. Padial

    2010-09-01

    Full Text Available

     

    RESUMEN


    Se ha analizado el efecto de dos tipos diferentes de entrenamiento en balonmano, uno que integra carga física y técnica dentro del mismo ejercicio (entrenamiento integrado, y otro que sigue los cánones tradicionales (entrenamiento de fuerza y entrenamiento técnico se trabajan por separado. Se trataba de comprobar el efecto de entrenar cargas pesadas más lanzamiento inmediato dentro de una acción táctica y contrastar esto con un método de entrenamiento más tradicional en balonmano. Muestra: 16 sujetos (16-17años, varones, pertenecientes al CDU de Granada. Procedimiento: Dos grupos de 8 sujetos cada uno, el primer grupo es el experimental que realiza el entrenamiento integrado (EI y el segundo grupo es el de control (GC que realiza el entrenamiento tradicional, ambos grupos entrenaron 2 veces a la semana, durante 7 semanas consecutivas. La intensidad del entrenamiento y la carga fue la misma para los dos grupos. Se realizaron medidas de la altura de salto en SJ, CMJ, SJ25, SJ50 y AB en la 3 y 7ª semana de entrenamiento, con plataforma de presión. Resultados: Con el entrenamiento integrado se produce un incremento muy significativo en todas manifest incremento mejor que el grupo en el con carga. nes: El entrenamiento integrado con cargas del de la manifestaciones de fuerza dinámica. Para jóvenes jugadores de balonmano se presenta como un método muy interesante de mejora de la fuerza máxima dinámica.
    PALABRAS CLAVE:

     

    ABSTRACT

    Researchers analyzed different methodologies handball training. One method combines strength and technique the same (integrated training the other traditional principles separate training and practice. during technical action contrast that a more

  11. Efectos del pH, NaCl, CaCl2 y la temperatura sobre la fuerza de cuajo de tres coagulantes/cuajos

    Directory of Open Access Journals (Sweden)

    Osmar Thomas Morillo Piña

    2014-06-01

    Full Text Available El cuajo y los coagulantes juegan un papel fundamental en el proceso de elaboración de queso y su actividad se ve afectada por diversos parámetros tecnológicos. En este sentido se determinó el efecto del pH, concentración de NaCl, CaCl2 y de la temperatura sobre la fuerza de cuajo de un coagulante microbiano experimental (BIOMI-13, una quimosina recombinante comercial (Maxiren® y un cuajo comercial de origen animal (BIOVEN, preparados a concentraciones de 0,05 g/mL; 0,0004 g/mL y 0,0008 g/mL, respectivamente. El efecto del pH fue evaluado en un intervalo de 5,0 a 7,5 y la concentración de NaCl y CaCl2 en la leche entre 0,02 y 0,16 M. El efecto de los iones de Na y Ca en las soluciones enzimáticas fue evaluado entre 0,04 y 0,80 M y la temperatura de incubación entre 20 y 70 ºC. Se determinó que los cambios de pH tienen un efecto inversamente proporcional sobre la actividad coagulante de la leche y la máxima actividad fue a pH 5 para los tres coagulantes evaluados. La concentración de NaCl en la leche tuvo un efecto adverso sobre la actividad coagulante, mientras que el incremento de la [CaCl2] aumentó la actividad alcanzando valores máximos a 0,04 M. La presencia iones de Na en las soluciones enzimáticas tuvo el mismo efecto observado en las pruebas de concentración de NaCl en la leche y se observó un aumento de la actividad relativa conforme se incrementó la concentración de iones de Ca en la solución. Los tres coagulantes/cuajos evaluados exhibieron la máxima fuerza de cuajo a 45 ºC y tuvieron una acción catalítica muy específica sobre la leche con una marcada dependencia a los parámetros evaluados, presentando algunas diferencias entre ellos debido posiblemente a la fuente y forma de obtención.

  12. Efectos del pH, NaCl, CaCl2 y la temperatura sobre la fuerza de cuajo de tres coagulantes/cuajos

    Directory of Open Access Journals (Sweden)

    Osmar Thomas Morillo Piña

    2014-07-01

    Full Text Available El cuajo y los coagulantes juegan un papel fundamental en el proceso de elaboración de queso y su actividad se ve afectada por diversos parámetros tecnológicos. En este sentido se determinó el efecto del pH, concentración de NaCl, CaCl2 y de la temperatura sobre la fuerza de cuajo de un coagulante microbiano experimental (BIOMI-13, una quimosina recombinante comercial (Maxiren® y un cuajo comercial de origen animal (BIOVEN, preparados a concentraciones de 0,05 g/mL; 0,0004 g/mL y 0,0008 g/mL, respectivamente. El efecto del pH fue evaluado en un intervalo de 5,0 a 7,5 y la concentración de NaCl y CaCl2 en la leche entre 0,02 y 0,16 M. El efecto de los iones de Na y Ca en las soluciones enzimáticas fue evaluado entre 0,04 y 0,80 M y la temperatura de incubación entre 20 y 70 ºC. Se determinó que los cambios de pH tienen un efecto inversamente proporcional sobre la actividad coagulante de la leche y la máxima actividad fue a pH 5 para los tres coagulantes evaluados. La concentración de NaCl en la leche tuvo un efecto adverso sobre la actividad coagulante, mientras que el incremento de la [CaCl2] aumentó la actividad alcanzando valores máximos a 0,04 M. La presencia iones de Na en las soluciones enzimáticas tuvo el mismo efecto observado en las pruebas de concentración de NaCl en la leche y se observó un aumento de la actividad relativa conforme se incrementó la concentración de iones de Ca en la solución. Los tres coagulantes/cuajos evaluados exhibieron la máxima fuerza de cuajo a 45 ºC y tuvieron una acción catalítica muy específica sobre la leche con una marcada dependencia a los parámetros evaluados, presentando algunas diferencias entre ellos debido posiblemente a la fuente y forma de obtención.

  13. Determining efficacy of breast cancer therapy by PET imaging of HER2 mRNA

    International Nuclear Information System (INIS)

    Paudyal, Bishnuhari; Zhang, Kaijun; Chen, Chang-Po; Wampole, Matthew E.; Mehta, Neil; Mitchell, Edith P.; Gray, Brian D.; Mattis, Jeffrey A.; Pak, Koon Y.; Thakur, Mathew L.; Wickstrom, Eric

    2013-01-01

    Introduction: Monitoring the effectiveness of therapy early and accurately continues to be challenging. We hypothesize that determination of Human Epidermal Growth Factor Receptor 2 (HER2) mRNA in malignant breast cancer (BC) cells by positron emission tomography (PET) imaging, before and after treatment, would reflect therapeutic efficacy. Method: WT4340, a peptide nucleic acid (PNA) 12-mer complementary to HER2 mRNA was synthesized together with -CSKC, a cyclic peptide, which facilitated internalization of the PNA via IGFR expressed on BC cells, and DOTA that chelated Cu-64. Mice (n = 8) with BT474 ER +/HER2+ human BC received doxorubicin (DOX, 1.5 mg/kg) i.p. once a week for six weeks. Mice (n = 8) without DOX served as controls. All mice were PET imaged with F-18-FDG and 48 h later with Cu-64-WT4340. PET imaging were performed before and 72 h after each treatment. Standardized uptake values (SUVs) were determined and percent change calculated. Animal body weight (BW) and tumor volume (TV) were measured. Results: SUVs for Cu-64-WT4340 after DOX treatment declined by 54% ± 17% after the second dose, 41% ± 15% after the fourth dose, and 29% ± 7% after the sixth dose, compared with 42% ± 22%, 31% ± 18%, and 13% ± 9% (p < 0.05) for F-18-FDG. In untreated mice, the corresponding percent SUVs for Cu-64-WT4340 were 145% ± 82%, 165% ± 39%, and 212% ± 105% of pretreatment SUV, compared with 108% ± 28%, 151% ± 8%, and 152% ± 35.5%, (p < 0.08) for F-18-FDG. TV in mice after second dose was 114.15% ± 61.83%, compared with 144.7% ± 64.4% for control mice. BW of DOX-treated mice was 103.4% ± 7.6% of pretreatment, vs. 100.1% ± 4.3% for control mice. Conclusion: Therapeutic efficacy was apparent sooner by molecular PET imaging than by determination of reduction in TV

  14. A web application for poloidal field analysis on HL-2M

    Energy Technology Data Exchange (ETDEWEB)

    Song, X.M., E-mail: songxm@swip.ac.cn; Pan, W.; Chen, L.Y.; Song, X.; Li, X.D.

    2014-05-15

    Highlights: • An original way to develop web application with a new framework (jQuery + PHP + Matlab) is introduced. • A convenient but powerful application for electromagnetic calculation is implemented. • The web application can run in any popular browser, on any hardware and in any operating system. • No any plugin is needed; no any maintenance is required. - Abstract: Recently, many web tools [1–3] in fusion society have been designed and demonstrated, which has been proved to be powerful and convenient to fusion researchers. Many physicists and engineers need a tool to compute the poloidal magnetic field for some purposes (for example, the calibration of magnetic probes for EFIT, the field null structure analysis for control, the design of some plasma diagnostic systems), so to develop a powerful and convenient web application for the calculation of magnetic field and magnetic flux produced by PF coils is very important. In this paper, a web application tool for poloidal field analysis on HL-2M with a totally original framework is presented. This web application is full of dynamic and interactive interface, and can run in any popular browser (IE, safari, firefox, opera), on any hardware (smart phone, PC, ipad, Mac) and operating system (ios, android, windows, linux, Mac OS). No any plugins is needed. The three layers (jQuery + PHP + Matlab) of this framework are introduced. The front top client layer is developed by jQuery code. The middle layer, which plays a role of a bridge to connect the server and client through socket communication, is developed by PHP code. The behind server layer is developed by Matlab, which compute the magnetic field or magnetic flux through a Special Function called Complete Elliptic Integral, and returns the results in the client favorite way, either by table or by JPG image. The field null structure and the vertical and radial field structure calculated by this tool are introduced with details. The idea to design a web

  15. Disorder of G2-M Checkpoint Control in Aniline-Induced Cell Proliferation in Rat Spleen.

    Directory of Open Access Journals (Sweden)

    Jianling Wang

    Full Text Available Aniline, a toxic aromatic amine, is known to cause hemopoietic toxicity both in humans and animals. Aniline exposure also leads to toxic response in spleen which is characterized by splenomegaly, hyperplasia, fibrosis and the eventual formation of tumors on chronic in vivo exposure. Previously, we have shown that aniline exposure leads to iron overload, oxidative DNA damage, and increased cell proliferation, which could eventually contribute to a tumorigenic response in the spleen. Despite our demonstration that cell proliferation was associated with deregulation of G1 phase cyclins and increased expression of G1 phase cyclin-dependent kinases (CDKs, molecular mechanisms, especially the regulation of G2 phase and contribution of epigenetic mechanisms in aniline-induced splenic cellular proliferation remain largely unclear. This study therefore, mainly focused on the regulation of G2 phase in an animal model preceding a tumorigenic response. Male Sprague-Dawley rats were given aniline (0.5 mmol/kg/day in drinking water or drinking water only (controls for 30 days, and expression of G2 phase cyclins, CDK1, CDK inhibitors and miRNAs were measured in the spleen. Aniline treatment resulted in significant increases in cell cycle regulatory proteins, including cyclins A, B and CDK1, particularly phosphor-CDK1, and decreases in CDK inhibitors p21 and p27, which could promote the splenocytes to go through G2/M transition. Our data also showed upregulation of tumor markers Trx-1 and Ref-1 in rats treated with aniline. More importantly, we observed lower expression of miRNAs including Let-7a, miR-15b, miR24, miR-100 and miR-125, and greater expression of CDK inhibitor regulatory miRNAs such as miR-181a, miR-221 and miR-222 in the spleens of aniline-treated animals. Our findings suggest that significant increases in the expression of cyclins, CDK1 and aberrant regulation of miRNAs could lead to an accelerated G2/M transition of the splenocytes, and

  16. A web application for poloidal field analysis on HL-2M

    International Nuclear Information System (INIS)

    Song, X.M.; Pan, W.; Chen, L.Y.; Song, X.; Li, X.D.

    2014-01-01

    Highlights: • An original way to develop web application with a new framework (jQuery + PHP + Matlab) is introduced. • A convenient but powerful application for electromagnetic calculation is implemented. • The web application can run in any popular browser, on any hardware and in any operating system. • No any plugin is needed; no any maintenance is required. - Abstract: Recently, many web tools [1–3] in fusion society have been designed and demonstrated, which has been proved to be powerful and convenient to fusion researchers. Many physicists and engineers need a tool to compute the poloidal magnetic field for some purposes (for example, the calibration of magnetic probes for EFIT, the field null structure analysis for control, the design of some plasma diagnostic systems), so to develop a powerful and convenient web application for the calculation of magnetic field and magnetic flux produced by PF coils is very important. In this paper, a web application tool for poloidal field analysis on HL-2M with a totally original framework is presented. This web application is full of dynamic and interactive interface, and can run in any popular browser (IE, safari, firefox, opera), on any hardware (smart phone, PC, ipad, Mac) and operating system (ios, android, windows, linux, Mac OS). No any plugins is needed. The three layers (jQuery + PHP + Matlab) of this framework are introduced. The front top client layer is developed by jQuery code. The middle layer, which plays a role of a bridge to connect the server and client through socket communication, is developed by PHP code. The behind server layer is developed by Matlab, which compute the magnetic field or magnetic flux through a Special Function called Complete Elliptic Integral, and returns the results in the client favorite way, either by table or by JPG image. The field null structure and the vertical and radial field structure calculated by this tool are introduced with details. The idea to design a web

  17. Reflective and antireflective coatings for the optical chain of the ASTRI SST-2M prototype

    Science.gov (United States)

    Bonnoli, Giacomo; Canestrari, Rodolfo; Catalano, Osvaldo; Pareschi, Giovanni; Perri, Luca; Stringhetti, Luca

    2013-09-01

    ASTRI is a Flagship Project of the Italian Ministry of Education, University and Research, led by the Italian National Institute of Astrophysics, INAF. One of the main aims of the ASTRI Project is the design, construction and on-field verification of a dual mirror (2M) end-to-end prototype for the Small Size Telescope (SST) envisaged to become part of the Cherenkov Telescope Array. The ASTRI SST-2M prototype is designed according to the Schwarzschild-Couder optical scheme, and adopts a camera based on Silicon Photo Multipliers (SiPM); it will be assembled at the INAF astronomical site of Serra La Nave on mount Etna (Catania, Italy) in the second half of 2014, and will start scientific validation phase soon after. With its 4m wide primary dish, the telescope will be sensitive to multi-TeV Very High Energy (VHE) gamma rays up to 100 TeV and above, with a point spread function of ~2 arcminutes and a wide (semiaperture 4.8°) corrected field of view. The peculiarities of the optical design and of the SiPM bandpass pushed towards specifically optimized choices in terms of reflective coatings for both the primary and the secondary mirror. Fully dielectric multi-layer coatings have been developed and tested as an option for the primary mirror, aiming to filter out the large Night Sky Background contamination at wavelengths λ>~700 nm. On the other hand, for the large monolithic secondary mirror a simpler design with quartz-overcoated aluminium has been optimized for incidences far from normality. The conformation of the ASTRI camera in turn pushed towards the design of a reimaging system based on thin pyramidal light guides, that could be optionally integrated in the focal surface, aiming to increase the fill factor. An anti-reflective coating optimized for a wide range of incident angles faraway from normality was specifically developed to enhance the UV-optical transparency of these elements. The issues, strategy, simulations and experimental results are thoroughly

  18. Investigating the Acid Failure of Aluminium Alloy in 2 M Hydrochloric Acid Using Vernonia amygdalina

    Directory of Open Access Journals (Sweden)

    Olugbenga A. Omotosho

    2012-04-01

    Full Text Available The acid failure of aluminium alloy in 2 M hydrochloric acid solution in the presence of Vernonia amygdalina extract was investigated using gasometric technique. Aluminium alloy coupons of dimension 4 cm by 1 cm were immersed in test solutions of free acid and also those containing extract volumes of 2, 3, 4 and 5 cm3 at ambient temperature for 30 minutes. The volumes of hydrogen gas evolved as a result of the rate of reaction were recorded and analyzed. Analysis revealed that maximum inhibitor efficiency which corresponds to the lowest corrosion rate was obtained at optimum inhibitor volumes of 5 cm3, with reduction in the corrosion rate observed to follow in order of increasing extract volumes. Adsorption study revealed that Temkin isotherm best described the metal surface interaction with the extract phytochemicals, with 12 minutes becoming the best exposure time for the phytochemicals to adsorb to the metal surface at all volumes. Statistical modelling of the corrosion rate yielded an important relationship suitable for estimating corrosion rate values once volumes of the extract is known. Microstructural studies, showed an indirect relationship between crack growth rates and extract volumes, while consistency of the irregular intermetallic phases increases with increasing extract volumes.

  19. Probe measurements of hydrogen fluxes during discharge cleaning in JFT-2M

    International Nuclear Information System (INIS)

    Matsuzaki, Y.

    1989-01-01

    Thermal desorption spectroscopy (TDS) has been applied during discharge cleaning in the JFT-2M tokamak to measure hydrogen fluxes. The TDS carbon sample, thickness 0.13 mm, was heated to 1000 0 C by direct current and the temperature distribution of the sample surface measured by infrared thermography. The probe was exposed to three types of plasma: Taylor-type discharge cleaning (TDC), ECR discharge cleaning (ECR-DC), and glow discharge cleaning (GDC). The TDS spectra show peak desorption at around 800 0 C. The hydrogen flux, obtained by integration of the TDS spectrum, decreases exponentially in the radial direction with decay length 7.4 cm and 5.8 cm in TDC and ECR-DC, respectively. The relation between hydrogen fluxes and water vapour production was investigated. In TDC, the amount of water vapour depends more strongly on the electron temperature of the plasma than on the hydrogen flux. In ECR-DC, the production of water vapour increases approximately linearly with the hydrogen-flux. In GDC, hydrogen fluxes were measured by TDS but no water vapour could be detected in the residual gases during the discharge. (orig.)

  20. A high throughput 2 m normal incidence monochromator for SURF-II

    International Nuclear Information System (INIS)

    Ederer, D.L.; Cole, B.E.; West, J.B.

    1980-01-01

    The high intrinsic brightness of the circulating electron beam at SURF-II is used as the entrance slit for a two-meter normal incidence monochromator. A typical beam size for the electron beam is 100 μm high by 2 mm wide yielding an obserbed resolution of 0.4 Angstroem with a 200 μm exit slit and a 2400 lines/mm grating. The instrument accepts a beam with a 65 mrad horizontal divergence and a 10 mrad vertical divergence. A plane pre-mirror used near normal incidence reflects the incoming radiation onto the 2 m grating; this combination provides a horizontal exit beam, and enables the experiment to be located three meters from the orbit tangent point. With magnesium fluoride coated aluminium optics a flux of 2 x 10'' photon/s x Angstroem at 1200 Angstroem is observed with a 10 mA circulating current. A flux of 5 x 10 10 photon/s x Angstroem at 600 Angstroem is obserbed with an osmium coated grating and a 10 mA circulating current. Sample spectra of the angle-resolved photoelectron spectrum of CO are presented. (orig.)

  1. Neutron star mass limit at 2M{sub ⊙} supports the existence of a CEP

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez-Castillo, D. [JINR Dubna, Bogoliubov Laboratory of Theoretical Physics, Dubna (Russian Federation); Benic, S. [University of Zagreb, Department of Physics, Zagreb (Croatia); Blaschke, D. [JINR Dubna, Bogoliubov Laboratory of Theoretical Physics, Dubna (Russian Federation); National Research Nuclear University (MEPhI), Moscow (Russian Federation); University of Wroclaw, Institute of Theoretical Physics, Wroclaw (Poland); Han, Sophia [University of Tennessee, Department of Physics and Astronomy, Knoxville, TN (United States); Oak Ridge National Laboratory, Physics Division, Oak Ridge, TN (United States); Typel, S. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany)

    2016-08-15

    We point out that the very existence of a ''horizontal branch'' in the mass-radius characteristics for neutron stars indicates a strong first-order phase transition and thus supports the existence of a critical endpoint (CEP) of first-order phase transitions in the QCD phase diagram. This branch would sample a sequence of hybrid stars with quark matter core, leading to the endpoint of stable compact star configurations with the highest possible baryon densities. Since we know of the existence of compact stars with 2M{sub ⊙}, this hypothetical branch has to lie in the vicinity of this mass value, if it exists. We report here a correlation between the maximal radius of the horizontal branch and the pressure at the onset of hadron-to-quark matter phase transition, which is likely to be a universal quantity of utmost relevance to the upcoming experiments with heavy-ion collisions at NICA and FAIR. (orig.)

  2. Results from recent hydrogen pellet acceleration studies with a 2-m railgun

    International Nuclear Information System (INIS)

    Kim, K.; Zhang, D.J.; King, T.; Haywood, R.; Manns, W.; Venneri, F.

    1989-12-01

    A new 3.2-mm-diameter, two-stage, fuseless, plasma-arc-driven electromagnetic railgun has been designed, constructed, and successfully operated to achieve a record velocity of 2.67 km/s( b ) for 3.2 mmD x 4 mmL solid hydrogen pellet. The first stage of this hydrogen pellet injector is a combination of a hydrogen pellet generator and a gas fun. The second stage is a 2-m-long railgun which serves as a booster accelerator. The gas fun accelerates a frozen hydrogen pellet to a medium velocity and injects it into the railgun through a perforated coupling piece, which also serves a pressure-relieving mechanism. An electrical breakdown of the propellant gas, which has followed the pellet from the gas fun into the railgun, forms a conducting plasma-arc armature immediately behind the pellet allowing for fuseless operation of the railgun. Study of the pressure profile and the behavior of the plasma-arc armature inside the railgun bore led to elimination of spurious arcing, which prevents operation of the railgun at high voltages (and, therefore, at high currents). A timing circuit that can automatically measure the pellet input velocity and allows for accurate control of arc initiation behind the pellet helps prevent pellet disintegration and mistriggering of the arc initiation circuit. Results from the recent cryogenic operation of the two-stage pellet acceleration system are reported. 11 refs., 2 figs., 1 tab

  3. Rates of E1, E2, M1, and M2 transitions in Ni II

    Science.gov (United States)

    Cassidy, C. M.; Hibbert, A.; Ramsbottom, C. A.

    2016-03-01

    Aims: We present rates for all E1, E2, M1, and M2 transitions among the 295 fine-structure levels of the configurations 3d9, 3d84s, 3d74s2, 3d84p, and 3d74s4p, determined through an extensive configuration interaction calculation. Methods: The CIV3 code developed by Hibbert and coworkers is used to determine for these levels configuration interaction wave functions with relativistic effects introduced through the Breit-Pauli approximation. Results: Two different sets of calculations have been undertaken with different 3d and 4d functions to ascertain the effect of such variation. The main body of the text includes a representative selection of data, chosen so that key points can be discussed. Some analysis to assess the accuracy of the present data has been undertaken, including comparison with earlier calculations and the more limited range of experimental determinations. The full set of transition data is given in the supplementary material as it is very extensive. Conclusions: We believe that the present transition data are the best currently available. Full Table 4 and Tables 5-8 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/587/A107

  4. Stress and Thermal Analysis of the In-Vessel RMP Coils in HL-2M

    International Nuclear Information System (INIS)

    Cen Yishun; Li Qiang; Cai Lijun; Jiang Jiaming; Li Guangsheng; Liu Yi; Ding Yonghua

    2013-01-01

    A set of in-vessel resonant magnetic perturbation (RMP) coils for MHD instability suppression is proposed for the design of a HL-2M tokamak. Each coil is to be fed with a current of up to 5 kA, operated in a frequency range from DC to about 1 kHz. Stainless steel (SS) jacketed mineral insulated cables are proposed for the conductor of the coils. In-vessel coils must withstand large electromagnetic (EM) and thermal loads. The support, insulation and vacuum sealing in a very limited space are crucial issues for engineering design. Hence finite element calculations are performed to verify the design, optimize the support by minimizing stress caused by EM forces on the coil conductors and work out the temperature rise occurring on the coil in different working conditions, the corresponding thermal stress caused by the thermal expansion of materials is evaluated to be allowable. The techniques to develop the in-vessel RMP coils, such as support, insulation and cooling, are discussed

  5. Magnetic order in Pu2M3Si5 (M = Co, Ni)

    International Nuclear Information System (INIS)

    Bauer, E D; Tobash, P H; Mitchell, J N; Kennison, J A; Ronning, F; Scott, B L; Thompson, J D

    2011-01-01

    The physical properties including magnetic susceptibility, specific heat, and electrical resistivity of two new plutonium compounds Pu 2 M 3 Si 5 (M = Co, Ni) are reported. Pu 2 Ni 3 Si 5 crystallizes in the orthorhombic U 2 Co 3 Si 5 structure type, which can be considered a variant of the BaAl 4 tetragonal structure, while Pu 2 Co 3 Si 5 adopts the closely related monoclinic Lu 2 Co 3 Si 5 type. Magnetic order is observed in both compounds, with Pu 2 Ni 3 Si 5 ordering ferromagnetically at T C = 65 K then undergoing a transition into an antiferromagnetic state below T N = 35 K. Two successive magnetic transitions are also observed at T mag1 = 38 K and T mag2 = 5 K in Pu 2 Co 3 Si 5 . Specific heat measurements reveal that these two materials have a moderately enhanced Sommerfeld coefficient γ ∼ 100 mJ/mol Pu K 2 in the magnetic state with comparable RKKY and Kondo energy scales.

  6. α-Synuclein overexpression increases dopamine toxicity in BE(2-M17 cells

    Directory of Open Access Journals (Sweden)

    Miller David W

    2010-03-01

    Full Text Available Abstract Background Oxidative stress has been proposed to be involved in the pathogenesis of Parkinson's disease (PD. A plausible source of oxidative stress in nigral dopaminergic neurons is the redox reactions that specifically involve dopamine and produce various toxic molecules, i.e., free radicals and quinone species. α-Synuclein, a protein found in Lewy bodies characteristic of PD, is also thought to be involved in the pathogenesis of PD and point mutations and multiplications in the gene coding for α-synuclein have been found in familial forms of PD. Results We used dopaminergic human neuroblastoma BE(2-M17 cell lines stably transfected with WT or A30P mutant α-synuclein to characterize the effect of α-synuclein on dopamine toxicity. Cellular toxicity was analyzed by lactate dehydrogenase assay and by fluorescence-activated cell sorter analysis. Increased expression of either wild-type or mutant α-synuclein enhances the cellular toxicity induced by the accumulation of intracellular dopamine or DOPA. Conclusions Our results suggest that an interplay between dopamine and α-synuclein can cause cell death in a neuron-like background. The data presented here are compatible with several models of cytotoxicity, including the formation of α-synuclein oligomers and impairment of the lysosomal degradation.

  7. Characteristics of edge localized mode in JFT-2M H-mode

    International Nuclear Information System (INIS)

    Matsumoto, Hiroshi; Funahashi, Akimasa; Goldston, R.J.

    1989-03-01

    Characteristics of edge localized mode (ELM/ERP) during H-mode plasma of JFT-2M were investigated. It was found that ELM/ERP is mainly a density fluctuation phenomena in the edge, and electron temperature in the edge except just near the separatrix is not very much perturbed. Several experimental conditions to controll ELM/ERP are, plasma density, plasma ion species, heating power, and plasma current ramping. ELM/ERPs found in low density deuterium discharge are suppressed by raising the density. ELM/ERPs are pronounced in hydrogen plasma compared with deuterium plasma. ELM/ERPs seen in hydrogen plasma or in near marginal H-mode conditions are suppressed by increasing the heating power. ELM/ERPs are found to be suppressed by plasma current ramp down, whereas they are enhanced by current ramp up. MHD aspect of ELM/ERP was investigated. No clear MHD features of ELM/ERP were found. However, reversal of mode rotation seen imediately after ELM/ERP suggests the temporal return to L-mode during the ELM/ERP event. (author)

  8. Sandwich structure of plasma edge during transition to improved confinement regime in L-2M stellarator

    International Nuclear Information System (INIS)

    Shchepetov, S V; Kholnov, Yu V; Fedyanin, O I; Kuznetsov, A B; Vasilkov, D G; Akulina, D K; Batanov, G M; Gladkov, G A; Grebenshchikov, S E; Meshcheryakov, A I

    2008-01-01

    Transitions to the regime with better confinement in the L-2M stellarator are presented. Transitions are indicated only at sufficiently high plasma densities, and for a given value of average density they appear only at higher heating powers. Each transition is easily identified by a sudden fast ( e ). In the bulk of the plasma parameters evolve slowly. Drastic changes are observed in the region close to the plasma boundary where two moderate order rational magnetic surfaces are located with the rotational transform μ taking the values 2/3 and 3/4. Relative values of plasma parameters' fluctuations and their spectrum widths decrease significantly in this region. The region has a definite sandwich structure being subdivided by the above-named moderate order rational magnetic surfaces into three smaller zones with different plasma parameter dynamics. Transition is triggered by local disturbances of plasma parameters that are caused by instabilities in the vicinity of magnetic surfaces where μ is equal to 2/3 or 3/4. Different hypotheses on the nature of the phenomenon are discussed

  9. Numerical investigation of disruption characteristics for the snowflake divertor configuration in HL-2M

    Science.gov (United States)

    Xue, L.; Duan, X. R.; Zheng, G. Y.; Liu, Y. Q.; Pan, Y. D.; Yan, S. L.; Dokuka, V. N.; Lukash, V. E.; Khayrutdinov, R. R.

    2016-05-01

    Cold and hot vertical displacement events (VDEs) are frequently related to the disruption of vertically-elongated tokamaks. The weak poloidal magnetic field around the null-points of a snowflake divertor configuration may influence the vertical displacement process. In this paper, the major disruption with a cold VDE and the vertical disruption in the HL-2M tokamak are investigated by the DINA code. In order to better illustrate the effect from the weak poloidal field, a double-null snowflake configuration is compared with the standard divertor (SD) configuration under the same plasma parameters. Computational results show that the weak poloidal magnetic field can be partly beneficial for mitigating the vertical instability of the plasma under small perturbations. For major disruption, the peak poloidal halo current fraction is almost the same between the snowflake and the SD configurations. However, this fraction becomes much larger for the snowflake in the event of a hot VDE. Furthermore, during the disruption for a snowflake configuration, the distribution of electromagnetic force on a vacuum vessel gets more non-uniform during the current quench.

  10. Numerical investigation of disruption characteristics for the snowflake divertor configuration in HL-2M

    International Nuclear Information System (INIS)

    Xue, L; Duan, X R; Zheng, G Y; Liu, Y Q; Pan, Y D; Yan, S L; Dokuka, V N; Khayrutdinov, R R; Lukash, V E

    2016-01-01

    Cold and hot vertical displacement events (VDEs) are frequently related to the disruption of vertically-elongated tokamaks. The weak poloidal magnetic field around the null-points of a snowflake divertor configuration may influence the vertical displacement process. In this paper, the major disruption with a cold VDE and the vertical disruption in the HL-2M tokamak are investigated by the DINA code. In order to better illustrate the effect from the weak poloidal field, a double-null snowflake configuration is compared with the standard divertor (SD) configuration under the same plasma parameters. Computational results show that the weak poloidal magnetic field can be partly beneficial for mitigating the vertical instability of the plasma under small perturbations. For major disruption, the peak poloidal halo current fraction is almost the same between the snowflake and the SD configurations. However, this fraction becomes much larger for the snowflake in the event of a hot VDE. Furthermore, during the disruption for a snowflake configuration, the distribution of electromagnetic force on a vacuum vessel gets more non-uniform during the current quench. (paper)

  11. Wireless Infrastructure M2M Network For Distributed Power Grid Monitoring.

    Science.gov (United States)

    Gharavi, Hamid; Hu, Bin

    2017-01-01

    With the massive integration of distributed renewable energy sources (RESs) into the power system, the demand for timely and reliable network quality monitoring, control, and fault analysis is rapidly growing. Following the successful deployment of Phasor Measurement Units (PMUs) in transmission systems for power monitoring, a new opportunity to utilize PMU measurement data for power quality assessment in distribution grid systems is emerging. The main problem however, is that a distribution grid system does not normally have the support of an infrastructure network. Therefore, the main objective in this paper is to develop a Machine-to-Machine (M2M) communication network that can support wide ranging sensory data, including high rate synchrophasor data for real-time communication. In particular, we evaluate the suitability of the emerging IEEE 802.11ah standard by exploiting its important features, such as classifying the power grid sensory data into different categories according to their traffic characteristics. For performance evaluation we use our hardware in the loop grid communication network testbed to access the performance of the network.

  12. Organization of remote control of spectrometers at the IBR-2M reactor

    International Nuclear Information System (INIS)

    Kirilov, A.S.; Murashkevich, S.M.; Okulov, R.Yu.; Petukhova, T.B.

    2008-01-01

    The development of network infrastructure in Dubna creates conditions for the remote supervision/control of experiment at the IBR-2M reactor beyond the JINR local network. The opportunity of observing an experiment from outside makes it possible to respond to errors or unforeseen, to save the reactor time. The principles of organization and peculiarities of implementation of the WebSonix system consisting of the central web-site and communication facilities for spectrometers are considered in the paper. The system allows one to reflect the actual condition of all the components of the instrument, survey log files, visualize the accumulated spectra and to control the experimental procedure on the instruments controlled by the software complex Sonix+ (OS Windows XP). The system is an independent instrument, it is easy to extend or change and easy to adapt to the instrument data specifics. The system is implemented using the PHP and Python scripts. The OS GNU/Linux Debian and web-server Apache 2 are installed on the web-site computer

  13. Estudio del efecto de la fuerza iónica en la adsorción de fenol con arcillas organofílicas: Equilibrio y cinética

    OpenAIRE

    Sun-Kou, María del Rosario; Lazo, José Carlos

    2009-01-01

    Se estudió el efecto de la fuerza iónica en el proceso de adsorción de fenol con arcillas organofilicas así como la cinética de reacción. Para el estudio de la fuerza iónica se evaluó la capacidad de adsorción de fenol de tres arcillas organofilicas, -preparadas por intercambio catiónico con sales de amonio cuaternario- en presencia de NaCI en soluciones cuya concentración de fenol varió en el rango de 50-800 ppm y la proporción de sal fue 2, 12 y 20% (w/v), respectivamente. Todas las arcilla...

  14. Propuesta de rediseño del canal "AOG" para la distribución de repuestos aeronáuticos de la Jefatura de Operaciones Logísticas de la Fuerza Aérea Colombiana

    Directory of Open Access Journals (Sweden)

    Carlos Adrián Castro Barona

    2009-01-01

    Es necesario resaltar la necesidad de adaptar y estandarizar las Polìticas, Objetivos y Misión contemplados en el Plan Estratégico Institucional 2006-2019 de la Fuerza Aérea, orientándolos a mejorar la logística integral de las aeronaves para de esta manera cumplir adecuadamente con la prioridad de nivel uno en el alistamiento de las mismas.

  15. Ejercicio físico enfocado en trabajos de fuerza resistencia para mujeres mayores de 45 años en pro del mantenimiento de la aptitud física

    OpenAIRE

    Cotacio Ávila, Luisa Fernanda

    2016-01-01

    Esta obra corresponde a la presentación de (TFI) trabajo final integrador como respuesta a la necesidad de incorporar ejercicios de fuerza resistencia en la clases de gimnasia para las mujeres mayores de 45 años en pro de mejorar la aptitud física y así poder generar un retraso en el proceso normal de envejecimiento. Facultad de Humanidades y Ciencias de la Educación

  16. The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat.

    Directory of Open Access Journals (Sweden)

    Susanne Kurz

    Full Text Available Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M and cell adhesion molecules, which contribute to the naked mole-rat's cancer resistance. Notably, A2M is known to dramatically decrease with age in humans. We hypothesize that this might facilitate tumour development. Here we found that A2M modulates tumour cell adhesion, migration and growth by inhibition of tumour promoting signalling pathways, e.g. PI3K / AKT, SMAD and up-regulated PTEN via down-regulation of miR-21, in vitro and in tumour xenografts. A2M increases the expression of CD29 and CD44 but did not evoke EMT. Transcriptome analysis of A2M-treated tumour cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumour promoting signalling pathways indicating a less tumorigenic environment mediated by A2M. By virtue of these multiple actions the naturally occurring A2M has strong potential as a novel therapeutic agent.

  17. The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat.

    Science.gov (United States)

    Kurz, Susanne; Thieme, René; Amberg, Ronny; Groth, Marco; Jahnke, Heinz-Georg; Pieroh, Philipp; Horn, Lars-Christian; Kolb, Marlen; Huse, Klaus; Platzer, Matthias; Volke, Daniela; Dehghani, Faramarz; Buzdin, Anton; Engel, Kathrin; Robitzki, Andrea; Hoffmann, Ralf; Gockel, Ines; Birkenmeier, Gerd

    2017-01-01

    Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat's cancer resistance. Notably, A2M is known to dramatically decrease with age in humans. We hypothesize that this might facilitate tumour development. Here we found that A2M modulates tumour cell adhesion, migration and growth by inhibition of tumour promoting signalling pathways, e.g. PI3K / AKT, SMAD and up-regulated PTEN via down-regulation of miR-21, in vitro and in tumour xenografts. A2M increases the expression of CD29 and CD44 but did not evoke EMT. Transcriptome analysis of A2M-treated tumour cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumour promoting signalling pathways indicating a less tumorigenic environment mediated by A2M. By virtue of these multiple actions the naturally occurring A2M has strong potential as a novel therapeutic agent.

  18. Asociación entre la fuerza de las piernas y el área de sección muscular transversal del músculo cuádriceps femoral y el grado de actividad física en octogenarios

    Directory of Open Access Journals (Sweden)

    Pedro Á. Latorre-Román

    2016-06-01

    Conclusiones. La fuerza muscular y la masa muscular del músculo cuádriceps mostraron una asociación significativa con el grado de actividad física en personas mayores. La fuerza muscular de las piernas fue un indicador útil para revelar la masa muscular y el grado de actividad física en estas personas, lo cual tiene relevancia en la práctica clínica.

  19. La consolidación de la democracia en Nicaragua, fuerzas armadas y partidos políticos en una democracia frágil

    Directory of Open Access Journals (Sweden)

    Secundino GONZÁLEZ

    2009-11-01

    Full Text Available RESUMEN: En el artículo se analiza la consolidación democrática en Nicaragua, destacando el importante papel desempeñado tanto por las Fuerzas Armadas como el juego de sistemas de partidos. Para el autor, estos dos elementos se mostraron plenamente funcionales para el proceso de consolidación democrática en este país. Además, sostiene que la transición a la democracia había comenzado en Nicaragua antes del proceso electoral que culminó en 1990.ABSTRACT: The article tries to analyze the democratic consolidation in Nicaragua, underlying the important role played by the Armed Forces and the party system. By the author, both of these elements have been shown very functional to the process of democratic consolidation in this country. Therefore, he sustaines also that the transition to democracy in Nicaragua had begun before the electoral process of 1990.

  20. "El ojo del amo engorda al ganado": Estrategias de control y disciplinamiento de la fuerza laboral Strategies of Control and Labor Discipline

    Directory of Open Access Journals (Sweden)

    Nuria Inés Giniger

    2011-06-01

    Full Text Available Las empresas han debido sofisticar sus estrategias de control y disciplinamiento laboral. Para esto han conformado verdaderos Sistemas Corporativos a partir de los cuales ponen en marcha políticas empresariales tendientes a la gestión de la fuerza de trabajo y a la difusión doctrinaria. Estos Sistemas Corporativos se configuran en una relación conflictiva entre los procesos globales y locales. El proceso desarrollado por la empresa siderúrgica Acindar para la consolidación de su Sistema Corporativo permite ver de qué forma estas tensiones se expresan y el alcance de dicho sistema.The companies have had more sophisticated strategies of control and labor discipline. For this, they have made real Corporate Systems from which they develop business policies in managing the work force and dissemination of doctrine. These Corporate Systems are configured in a conflicting relationship between global and local processes. The process developed by the steel company Acindar to consolidate its Corporate System allows us to see how these tensions are expressed and the range of that system.

  1. Sobre condiciones suficientes de estabilidad para sistemas mecánicos sometidos a fuerzas dependientes de la velocidad por un método variacional

    Directory of Open Access Journals (Sweden)

    Rodríguez Rebollo, Rafael

    1979-05-01

    Full Text Available We are considering here the stability of a mechanical system state, either discrete or continuous, subject to overall stresses, whether or not dependent on speed, having variational movement equations for small disturbances which are differential equations of the second degree in respect to time and with a formal structure, frequent in several problems of stability in continuous media and system of solid rigid particles. Stability and asymptotic stability criteria are obtained, thus generalising known results, considering self-value problems for exponential type results in respect to time.

    Consideramos la estabilidad de un estado de un sistema mecánico, discreto o continuo, sometido a fuerzas generalizadas dependientes o no de la velocidad y cuyas ecuaciones variacionales de movimiento, para pequeñas perturbaciones, son ecuaciones diferenciales de segundo orden respecto del tiempo y de una estructura formal frecuente en diversos problemas de estabilidad de medios continuos y de sistemas de partículas y de sólidos rígidos. Se obtienen criterios de estabilidad y de estabilidad asintótica y se generalizan resultados conocidos, considerando los correspondientes problemas de autovalores para soluciones de tipo exponencial respecto del tiempo.

  2. El umbral de gravedad en el crimen de agresión: ¿una nueva categoría en los usos ilícitos de la fuerza?

    Directory of Open Access Journals (Sweden)

    Luciano Pezzano

    2016-03-01

    Full Text Available En este ensayo nos referiremos a los efectos que en las normas internacionales relativas al uso de la fuerza puede tener el denominado “umbral de gravedad” que se encuentra en la definición del crimen de agresión en el artículo 8 bis del Estatuto de Roma. Haciendo hincapié en la gravedad como característica definitoria de la agresión, buscaremos determinar si el umbral del artículo 8 bis introduce una nueva categoría dentro de los usos ilícitos de la fuerza. Para ello, analizaremos la agresión en el contexto de las normas internacionales relativas al uso de la fuerza y las disposiciones del artículo 8 bis, en particular, la cláusula de umbral, las referencias a la resolución 3314 (XXIX de la Asamblea General de las Naciones Unidas y los “entendimientos” aprobados por la Conferencia de Revisión.

  3. DETERMINACIÓN DE LOS NIVELES DE FUERZA MÁXIMA APLICADA, VELOCIDAD Y POTENCIA POR MEDIO DE UN TEST CRECIENTE EN PRES DE BANCA PLANO, EN LEVANTADORES ESPAÑOLES.

    Directory of Open Access Journals (Sweden)

    Joaquín Figueroa Alchapar

    2010-10-01

    Full Text Available

     

    Se evaluaron 9 levantadores que realizaron 2 test en el ejercicio de pres debanca: a Progresivo con pesos ligeros a máximos (MRPr b Máxima Repetición (MRD. Semidió la fuerza (FN, velocidad (V y potencia (W con cada peso movilizado,determinándose el máximo peso factible de movilizar 1 vez y no dos (MR Se observaroncorrelaciones significativas entre la MR del test MRPr y la del MRD, la W máxima, absolutay relativa al peso corporal y la MR absoluta y relativa al peso corporal, no se produjerondiferencias significativas (p<0,05 entre la MR obtenidas en el test MRPr y MRD. Se aceptala aplicación del test MRPr para determinar los niveles de FN, V, W, y MR, localizar losniveles de W máxima, con relación al % MR, y determinar el perfil de rendimiento así comolos cambios inducidos por los entrenamientos de fuerza.

    Palabras Clave: Fuerza Máxima, Velocidad, potencia

  4. Wireless Device-to-Device (D2D) Links for Machine-to-Machine (M2M) Communication

    DEFF Research Database (Denmark)

    Pratas, Nuno; Popovski, Petar

    2017-01-01

    Device-to-Device (D2D) communications will play an important role in the fifth generation (5G) cellular networks, by increasing the spatial reuse of spectrum resources and enabling communication links with low latency. D2D is composed of two fundamental building blocks: proximity discovery...... and direct communication between nearby users. Another emerging trend in wireless cellular systems is Machine-to-Machine (M2M) communications, often characterized by fixed, low transmission rates. In this chapter we motivate the synergy between D2D and M2M, and present technologies that enable M2M-via-D2D...

  5. G2M arrest and apoptosis in murine T lymphoma cells following exposure to 212Bi alpha particle irradiation

    International Nuclear Information System (INIS)

    Palayoor, S.T.; Humm, J.L.; Macklis, R.M.

    1993-01-01

    Asynchronous exponentially growing EL4 murine T lymphoma cells were exposed either to high LET α-radiation from 212 Bi-DTPA or to γ-radiation from a 137 Cs source. Radiation-induced cell cycle perturbation was studied by flow cytometry. Alpha irradiation, like γ, transiently arrested cells in the G2M phase in a dose-dependent manner. The maximum percentages of cells accumulated in G2M 18 h after α- and γ-irradiation were comparable, though the dose-response relationships differed. The ''RBE'' value for G2M block for α- versus γ-radiation was approx. 4. (author)

  6. Lateral structure of (TiSe2)n(NbSe2)m superlattices

    International Nuclear Information System (INIS)

    Noh, M.; Shin, H.; Jeong, K.; Spear, J.; Johnson, D.C.; Kevan, S.D.; Warwick, T.

    1997-01-01

    The structures of a series of (TiSe 2 ) n (NbSe 2 ) m superlattices grown through controlled crystallization of designed multilayer reactants have been studied. X-ray diffraction of the data of the superlattices after crystallization show considerable preferred orientation, with the basal plane of the dichalcogenide structure parallel to the substrate to within 0.1 degree. Lattice refinement using the observed (00scr(l)) diffraction maxima yields lattice parameters along the c axis that are consistent with those expected based on the target superlattices and lattice parameters of the binary constituents. These (00scr(l)) diffraction data, however, contain no information about the crystalline structure in the ab plane of the superlattice associated with the preferred c-axis orientation. Off-specular x-ray diffraction (XRD), scanning electron microscopy, and scanning transmission x-ray microscopy (STXM) were used to explore the structure and homogeneity of the superlattices in the ab plane. XRD results rule out preferred long-range orientational order of the ab plane. Between grains, both the backscattered electron images and STXM images show grain domain structure in the ab plane with a characteristic grain domain size of approximately 50 μm. X-ray absorption microscopy in the STXM mode obtained at the Ti L 2,3 edge shows that the titanium in the superlattices is present as both octahedral Ti consistent with the TiSe 2 structure and metallic Ti. A comparison of the data obtained from these techniques highlights chemical information, which can be deduced on a submicrometer range from the space resolved spectra obtained using STXM. copyright 1997 American Institute of Physics

  7. Effects of complex magnetic ripple on fast ions in JFT-2M ferritic insert experiments

    International Nuclear Information System (INIS)

    Shinohara, Kouji; Kawashima, H.; Tsuzuki, K.

    2003-01-01

    In JFT-2M, the ferritic steel plates (FPs) were installed inside the vacuum vessel all over vacuum vessel, which is named Ferritic Inside Wall (FIW), as the third step of the Advanced Material Tokamak Experiment (AMTEX) program. A toroidal field ripple was reduced, however the magnetic field structure has become the complex ripple structure with a non-periodic feature in the toroidal direction because of the existence of other components and ports that limit the periodic installation of FPs. Under the complex magnetic ripple, we investigated its effect on the heat flux to the first wall due to the fast ion loss. The small heat flux was observed as the result of the reduced magnetic ripple by FIW. Additional FPs were also installed outside the vacuum vessel to produce the localized larger ripple. The small ripple trapped loss was observed when the shallow ripple well exist in the poloidal cross section, and the large ripple trapped loss was observed when the ripple well hollow out the plasma region deeply. The experimental results were almost consistent with the newly developed Fully three Dimensional magnetic field Orbit-Following Monte-Carlo (F3D OFMC) code including the three dimensional complex structure of the toroidal field ripple and the non-axisymmetric first wall geometry. By using F3D OFMC, we investigated the effect on the ripple trapped loss of the localized larger ripple produced by FPs in detail. The ripple well structure, e.g. the thickness of the ripple well, is important for ripple trapped loss in complex magnetic ripple rather than the value defined at one position in a poloidal cross section. (author)

  8. Clinical significations of G2-M stage partial synchronization on radiation therapies of uterine cervical carcinomas

    International Nuclear Information System (INIS)

    Sasaki, Hiroshi

    1981-01-01

    The present study revealed that irradiation-induced changes of repopulation and redistribution played an important role in radiosensitivity and cure process of human uterine cervical carcinoma. DNA measurements by a microspectrophotometer were made on Feulgen stained biopsy specimens obtained from 20 patients. On the other hand, flow-microfluorometric measurements with Fried's computed cell cycle analysis were made on transplanted human cervical carcinomas. The mean nuclear DNA amount of human cervical carcinoma cells increased according as the irradiation doses increase until 2,000 rad. Moreover, as regards with the mean nuclear diameter of cancer cells the same phenomenon was recognized, and there was an interrelation between the increase of mean nuclear DNA amount and that of mean nuclear diameter. This phenomenon was proved in nuclear DNA analysis by flow-microfluorometric measurements on transplanted human cervical carcinoma in nude mice. Computed cell cycle analysis of F.M.F. data demonstrated that this phenomenon was due to irradiation-induced changes of repopulation and redistribution. That is to say, irradiation induces the increase of cycling cells and then partial synchronization to G2-M stage. Examination of the interrelation between this phenomenon at 500 rad and 5 years survival rate demonstrated that there was more increase of nuclear DNA amount in the good prognosis group than in the poor prognosis group. Estimation of residual cells near the G1 stage at 2,000 rad demonstrated that there were more residual cells near the G1 stage in the poor prognosis group than in the good prognosis group. (author)

  9. Coherent edge fluctuation measurements in H-mode discharges on JFT-2M

    International Nuclear Information System (INIS)

    Nagashima, Y; Shinohara, K; Hoshino, K; Ejiri, A; Tsuzuki, K; Ido, T; Uehara, K; Kawashima, H; Kamiya, K; Ogawa, H; Yamada, T; Shiraiwa, S; Ohara, S; Takase, Y; Asakura, N; Oyama, N; Fujita, T; Ide, S; Takenaga, H; Kusama, Y; Miura, Y

    2004-01-01

    Results of coherent edge fluctuation measurements using three diagnostics (a reciprocating Langmuir probe, a two channel O-mode reflectometer, and fast magnetic probes) in H-mode discharges on JFT-2M are presented. In discharges in which a high recycling steady (HRS) H-mode phase is obtained through a transient phase with slightly enhanced D α intensity, two types of coherent fluctuations are observed. The higher frequency mode (around 300 kHz) is the high frequency mode (HFM) observed in the HRS H-mode (Kamiya K et al 2003 9th IAEA Tech. Meeting H-mode Workshop Topic B-14). The lower frequency mode has a frequency of around 80 kHz. The HFM is detected by a Langmuir probe over a wide region in the SOL, as well as by the reflectometer and magnetic probes. However, the HFM is not detected by the higher frequency (38 GHz) channel of the reflectometer after the HRS transition, suggesting that the HFM is not located deeply inside the plasma. The 80 kHz mode is detected by both channels of the reflectometer and by a Langmuir probe, but not by magnetic probes, suggesting that it is an electrostatic mode. In contrast to the HFM, the 80 kHz mode is detected by the Langmuir probe only near the separatrix during the transient phase, which leads to either the HRS phase or the ELMy phase, and is similar to the fluctuations reported in Shinohara K et al (1998 J. Plasma Fusion Res. 74 607)

  10. Uncoupling protein-2 mRNA expression in mice subjected to intermittent hypoxia

    Directory of Open Access Journals (Sweden)

    Luciana Rodrigues Vieira

    2015-04-01

    Full Text Available Objective: To investigate the effect of intermittent hypoxia-a model of obstructive sleep apnea (OSA-on pancreatic expression of uncoupling protein-2 (UCP2, as well as on glycemic and lipid profiles, in C57BL mice. Methods: For 8 h/day over a 35-day period, male C57BL mice were exposed to intermittent hypoxia (hypoxia group or to a sham procedure (normoxia group. The intermittent hypoxia condition involved exposing mice to an atmosphere of 92% N and 8% CO2 for 30 s, progressively reducing the fraction of inspired oxygen to 8 ± 1%, after which they were exposed to room air for 30 s and the cycle was repeated (480 cycles over the 8-h experimental period. Pancreases were dissected to isolate the islets. Real-time PCR was performed with TaqMan assays. Results: Expression of UCP2 mRNA in pancreatic islets was 20% higher in the normoxia group than in the hypoxia group (p = 0.11. Fasting serum insulin was higher in the hypoxia group than in the normoxia group (p = 0.01. The homeostasis model assessment of insulin resistance indicated that, in comparison with the control mice, the mice exposed to intermittent hypoxia showed 15% lower insulin resistance (p = 0.09 and 21% higher pancreatic β-cell function (p = 0.01. Immunohistochemical staining of the islets showed no significant differences between the two groups in terms of the area or intensity of α- and β-cell staining for insulin and glucagon. Conclusions: To our knowledge, this is the first report of the effect of intermittent hypoxia on UCP2 expression. Our findings suggest that UCP2 regulates insulin production in OSA. Further study of the role that UCP2 plays in the glycemic control of OSA patients is warranted.

  11. The silence of MUC2 mRNA induced by promoter hypermethylation associated with HBV in Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Ling Yang

    2013-01-01

    Full Text Available Abstract Background To evaluate the promoter methylation status of MUC2 gene and mRNA expression in patients with hepatocellular carcinoma. Methods We analyzed MUC2 methylation by MSP, and MUC2 mRNA by real-time PCR in 74 HCC. Results MUC2 mRNA were lower in HCC tissues (Mean -ΔCt = −4.70 than that in Non-HCC tissues (Mean -ΔCt = −2.98. Expression of MUC2 was elevated in only 23 (31.08% of the 74 HCC patients. MUC2 promoter was hypermethylated in 62.2% (46/74 of HCCs, and in only 18.9% (14/74 of non-tumor samples. MUC2 mRNA were lower in HCC patients with hypermethylation (Mean -ΔΔCt = −2.25 than those with demethylation (Mean -ΔΔCt = −0.22, and there is a decreased tendency for MUC2 mRNA in HCC patients with promoter hypermethylation (p = 0.011. There was a significantly correlation found between MUC2 mRNA and HBV and AFP in HCC. The loss of MUC2 mRNA and hypermethylation could be poor prognostic factors. After treated by 5-Aza-CdR and TSA, we found that MUC2 mRNA induced significantly in 7721, Huh7 and HepG2 cells. Conclusion The results suggested that MUC2 mRNA silenced by promoter hypermethylation is associated with high levels HBV in HCC.

  12. MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction

    Science.gov (United States)

    Kim, Kyung Mok; Chung, Ki Wung; Jeong, Hyeong Oh; Lee, Bonggi; Kim, Dae Hyun; Park, June Whoun; Kim, Seong Min; Yu, Byung Pal; Chung, Hae Young

    2018-01-01

    Age-associated renal fibrosis is related with renal function decline during aging. Imbalance between accumulation and degradation of extracellular matrix is key feature of fibrosis. In this study, RNA-sequencing (RNA-Seq) results based on next-generation sequencing (NGS) data were analyzed to identify key proteins that change during aging and calorie restriction (CR). Among the changed genes, A2M and MMP2, which are known to interact, exhibited the highest between centrality (BC) and degree values when analyzed by protein–protein interaction (PPI). Both mRNA and protein levels of MMP2 and A2M were increased during aging. Furthermore, the interaction between MMP2 and A2M was verified by immunoprecipitation and immunohistochemistry. MMP2 activity was further measured under the presence or absence of A2M-MMP2 interaction. MMP2 activity, which was increased under the absence of A2M-MMP2 interaction, was significantly decreased under the presence of interactions in aged kidney. We further hypothesized that the interaction between A2M-MMP2 played a role in the inactivation of MMP2 leading to accumulation of ECM including collagen type I and IV. Aged kidney showed highly accumulated MMP2 substrate proteins despite of increased MMP2 protein expression and CR blunted these accumulation. Additional in vivo analysis revealed that the signal transducer and activator of transcription (STAT) 3 transcriptional factor was significantly increased thus increasing A2M expression during aging. STAT3 activating cytokines were also highly increased in aged kidney. In conclusion, the results of the present study indicate that A2M-MMP2 interaction has a role in age-associated renal ECM accumulation and in the suppression such fibrosis by CR. PMID:29464020

  13. Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats

    NARCIS (Netherlands)

    van Tok, Melissa N.; Satumtira, Nimman; Dorris, Martha; Pots, Desirée; Slobodin, Gleb; van de Sande, Marleen G.; Taurog, Joel D.; Baeten, Dominique L.; van Duivenvoorde, Leonie M.

    2017-01-01

    Spondyloarthritis (SpA) does not display the typical features of auto-immune disease. Despite the strong association with MHC class I, CD8(+) T cells are not required for disease induction in the HLA-B27/Huβ2m transgenic rats. We used Lewis HLA-B27/Huβ2m transgenic rats [21-3 × 283-2]F1,

  14. Recent results from the CMD-2 detector at the VEPP-2M collider

    Energy Technology Data Exchange (ETDEWEB)

    Solodov, E.P. [Budker Institute of Nuclear Physics, Novosibirsk (Russian Federation)

    1997-01-01

    The general-purpose detector CMD-2 is taking data at the Novosibirsk VEPP-2M e{sup -}e{sup -} collider in the energy range 360-1400 MeV, with luminosity of {approx} 5.0 x 10{sup 30} cm{sup -2} s{sup -1} for the {phi} resonance region. Data from {approx} 1500 nb{sup -1} of integrated luminosity around 1.02 GeV and {approx}500 nb{sup -1} in the 600-1000 MeV range have been collected and preliminary analyses performed. We present progress in studies of the {phi} meson and K{sub S}K{sub L} systems: (a) measurement of the {phi} meson parameters; (b) searches for {phi} rare decays. The new upper limits B({phi}{yields}{eta}{prime} {gamma}) < 2.4 x 10{sup -4}, B({phi} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -}) < 1.0 x 10{sup -4}, and B({phi} {yields} f{sub 0}{gamma}) < 8 x 10{sup -4} have been obtained; (c) the study of the K{sub L} interactions in the CsI calorimeter; (d) with the help of 32,340 tagged K{sub S}, the semi-rare decay of K{sub S} {yields} {pi}{sup +}{pi}{sup -}{gamma} has been observed with a branching ratio of (1.82 {+-} 0.49)x10{sup -3}; and (e) selection of events with K{sub S}K{sub L} coupled decays and interactions. The regeneration cross section of the low moments K{sub L} was found to be {sigma}{sub reg}{sup Be} = 63 {+-} 19 mb. Data from the 600-1000 MeV energy range are used for high-accuracy measurement of the e{sup +}e{sup -} annihilation cross section, and the preliminary analysis is presented in this paper.

  15. Rotation measure synthesis at the 2 m wavelength of the FAN region: unveiling screens and bubbles

    Science.gov (United States)

    Iacobelli, M.; Haverkorn, M.; Katgert, P.

    2013-01-01

    Context. Rotation measure synthesis of the Westerbork Synthesis Radio Telescope (WSRT) observations at λ ~ 2 m of the FAN region at l = 137°, b = +7° shows the morphology of structures in the ionized interstellar medium. Aims: We interpret the diffuse polarized synchrotron emission in terms of coherent structures in the interstellar medium and the properties of the interstellar magnetic field. Methods: We performed statistical analysis of the polarization data cube obtained through rotation measure synthesis. For the first time, cross-correlation is applied to identify and characterize polarized structures in Faraday depth space. Complementary information about the medium are derived from Hα emission, properties of nearby pulsars, and optical polarized starlight measurements. Results: We find an overall asymmetric Faraday dispersion function in a Faraday depth range of [-13, +5] rad m-2, which is peaked around -1 rad m-2. Three morphological patterns are recognized, showing structures on scales from degrees down to the beam size. The first structure is a nearby synchrotron emission component with low Faraday depth, filling the entire field of view. The second pattern is a circular polarization structure with enhanced (negative) Faraday depth, which has the same morphology as a low-emission region within the third component. This third component is interpreted as the background in which the circular structure is embedded. At low Faraday depth values, a low gradient across the imaged field is detected, almost aligned with the Galactic plane. Power spectra of polarized structures in Faraday depth space provide evidence of turbulence. Conclusions: A sign reversal in Faraday depth from the nearby component to the circular component indicates a reversal of the magnetic field component along the line of sight, from towards the observer and nearby to away from the observer at large distances. The distance to the nearby, extended component is estimated as ≲100 pc

  16. Genetic Control of the Trigger for the G2/M Checkpoint

    Energy Technology Data Exchange (ETDEWEB)

    Hall, Eric J. [Columbia University; Smilenov, Lubomir B. [Columbia University; Young, Erik F. [Columbia University

    2013-10-01

    system, the engagement of the G2/M checkpoint only occurs at doses where most of the cells are bound for mitotic catastrophe. Further, compound haploinsufficiency of various radiosensitizing genes does not impact the threshold of activation. The experiments confirm a threshold of activation for the G2/M checkpoint, hinting at two separate radiation response programs acting below and above this threshold. Small RNA transfer in bystander effect biology: Small regulatory RNA molecules have now risen in prominence and utility. Specific examples are small interfering RNAs (siRNA) which are employed in cell level expression ablation projects and micro-RNAs (miRNA) which are a pool of short transcription products which serve to modulate the expression of other transcripts emerging from the genome in a meta-regulatory fine tuning of gene expression. The existing tenets of bystander effect radiation biology involve the communication of inflammatory mediators or direct intercellular communication of reactive oxygen/nitrogen species in cell-to-cell communicative organelles called gap junctions. By ablating gap junctions, reducing the ROS/inflammatory cytokine expression one can attenuate bystander effect signaling in cell culture systems. We hypothesized that miRNAs are a competent intercellular communication molecule and therefore a possible component of the bystander response. This view is supported by the observation that miRNA are secreted from cells in exosomes found in the circulation. This circulating pool reports disease type and severity in humans. We proposed use of microbeam irradiation technology at our facilities and enhancement of this capability with a new sorting technology which would allow us to sort irradiated and non-irradiated cells with absolute fidelity. Pursuing direct quantitative transfer assessment, we succeeded in designing and constructing a new add-on sorting appliance which harmonized with our existing instruments. The sorter allowed us to gently sort

  17. A cost-effective method to fabricate VO{sub 2} (M) nanoparticles and films with excellent thermochromic properties

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Hua [CAS Key Laboratory of Renewable Energy, Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Xiao, Xiudi, E-mail: xiaoxd@ms.giec.ac.cn [CAS Key Laboratory of Renewable Energy, Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640 (China); Lu, Xuanming [CAS Key Laboratory of Renewable Energy, Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Chai, Guanqi; Sun, Yaoming; Zhan, Yongjun; Xu, Gang [CAS Key Laboratory of Renewable Energy, Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640 (China)

    2015-07-05

    Highlights: • Via solvent–thermal and pyrolysis method, VO{sub 2} (M) powder was synthesized in air. • Aiding by grinding, VO{sub 2} (M) nanoparticles with the size of 22 nm were obtained. • The VO{sub 2} films show great thermochromic properties with T{sub lum} = 62.1% and ΔT{sub sol} = 12.4%. • The haze is down to 1.9%, which is superior with films prepared by other methods. - Abstract: In this paper, high crystallinity and pure phase VO{sub 2} (M) powder is synthesized by a novel and facile method. Aiding by additional manual grinding and etching process, 22 nm high-quality VO{sub 2} (M) nanoparticles can be obtained. The structure and properties of the VO{sub 2} (M) particles were characterized by X-ray diffraction analysis, transmission electron microscopy, differential scanning calorimetry and UV–vis–NIR spectrophotometer. After mixing VO{sub 2} (M) nanoparticles with transparent polymer, thin films prepared by grinded VO{sub 2} nanoparticles show excellent thermochromic properties. The solar modulation ability is up to 12.4% with luminous transmittance of 62.7%. Moreover, The haze of films prepared by grinded VO{sub 2} (M) nanoparticles is down to 1.9%, which is far less than that of films prepared by original VO{sub 2} (Haze = 8.5%) and etched VO{sub 2} particles (Haze = 4.6%). Dramatical improvement of thermochromic property and definition indicate that it is a promising method to prepare large-scale VO{sub 2} nanoparticles and cost-effective smart window.

  18. Intra-articular sodium hyaluronate 2 mL versus physiological saline 20 mL versus physiological saline 2 mL for painful knee osteoarthritis: a randomized clinical trial

    DEFF Research Database (Denmark)

    Lundsgaard, C.; Dufour, N.; Fallentin, E.

    2008-01-01

    , Knee Injury and Osteoarthritis Outcome Score (KOOS), Osteoarthritis Research Society International (OARSI) criteria, and global assessment of the patient's condition. Results: The mean age of the patients was 69.4 years; 55% were women. The effects of hyaluronate 2 mL, physiological saline 20 m......Objective: Methodological constraints weaken previous evidence on intra-articular viscosupplementation and physiological saline distention for osteoarthritis. We conducted a randomized, patient- and observer-blind trial to evaluate these interventions in patients with painful knee osteoarthritis....... Methods: We centrally randomized 251 patients with knee ostcoarthritis to four weekly intra-articular injections of sodium hyaluronate 2 mL (Hyalgan(R) 10.3 mg/mL) versus physiological saline 20 mL (distention) versus physiological saline 2 mL (placebo) and followed patients for 26 weeks. Inclusion...

  19. El escenario de competencia de la Industria Gastronómica de Cancún basado en las cinco fuerzas de Porter.

    Directory of Open Access Journals (Sweden)

    Damayanti Estolano Cristerna

    2013-01-01

    Full Text Available El incremento de la afluencia turística de Cancún beneficia las utilidades de los establecimientos gastronómicos, y viceversa. Este trabajo evidencia la relevancia y la relación de la industria turística y gastronómica, contribuyendo así a investigaciones más específicas sobre el sector gastronómico. El objetivo de esta investigación fue describir el escenario de competencia de los últimos tres años con base en las Cinco Fuerzas que forman la estrategia de Michael Porter, diseñando una investigación no experimental descriptiva, que consistió principalmente en la consulta documental y de fuentes electrónicas, trabajo de campo y entrevistas. Los resultados obtenidos mostraron que: el crecimiento de los nuevos participantes es bajo; los clubes de precio están sustituyendo a los proveedores de materia prima; los compradores residentes son los más sensibles al precio; los productos sustitutos satisfacen la necesidad de alimentación a través de tiendas de conveniencia; los competidores se ven afectados por la existencia de los hoteles Todo Incluido en la Zona Hotelera y el comercio informal y/o ambulante en la Zona Centro. Con esta investigación se aplicó una teoría con abundante evidencia empírica en la relevante industria gastronómica de Cancún, obteniendo como resultado un producto para los investigadores y actores de la industria.

  20. Heat dissipation research on the water-cooling channel of HL-2M in-vessel coils

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, J., E-mail: jiangjiaming@swip.ac.cn; Liu, Y.; Chen, Q.; Ji, X.Q.

    2017-04-15

    Highlights: • The joule heat of in-vessel coils is very difficult to dissipate inside HL-2M vacuum vessel. • Heat dissipation model of the coil includes the joule heat model, the heat conduction model and the heat transfer model. • The CFD analysis has been done for the coil-water cooling, with comparison with the date of theoretical analysis and experiment. • The result shows water-cooling channel is good for the joule heat transfer and taken away. - Abstract: HL-2M in-vessel coils are positioned in high vacuum circumstance, and they will generate joule heat when they carry 15 kA electrical current, but joule heat is very difficult to dissipate in vacuum, so a hollow cable with 8 mm inner diameter is design as water-cooling channel for heat convection. By using the methods of the theoretical derivation, together with CFD numeric simulation method and the experiment of the heat transfer, the water channel of HL-2M in-vessel coils has been studied, and the temperature of HL-2M in-vessel coils under different cooling water flow rates is obtained and acceptable. Simultaneously, the external cooling water supply system parameters for the water-cooling channel of the coils are estimated. Three methods’ results are in good agreement; the theoretical model is verified and could be popularized for predicting the temperature rise of HL-2M in-vessel coils.

  1. VO2(B conversion to VO2(A and VO2(M and their oxidation resistance and optical switching properties

    Directory of Open Access Journals (Sweden)

    Zhang Yifu

    2016-03-01

    Full Text Available Vanadium dioxide VO2 has been paid in recent years increasing attention because of its various applications, however, its oxidation resistance properties in air atmosphere have rarely been reported. Herein, VO2(B nanobelts were transformed into VO2(A and VO2(M nanobelts by hydrothermal route and calcination treatment, respectively. Then, we comparatively studied the oxidation resistance properties of VO2(B, VO2(A and VO2(M nanobelts in air atmosphere by thermo-gravimetric analysis and differential thermal analysis (TGA/DTA. It was found that the nanobelts had good thermal stability and oxidation resistance below 341 °C, 408 °C and 465 °C in air, respectively, indicating that they were stable in air at room temperature. The fierce oxidation of the nanobelts occurred at 426, 507 and 645 °C, respectively. The results showed that the VO2(M nanobelts had the best thermal stability and oxidation resistance among the others. Furthermore, the phase transition temperatures and optical switching properties of VO2(A and VO2(M were studied by differential scanning calorimetry (DSC and variable temperature infrared spectra. It was found that the VO2(A and VO2(M nanobelts had outstanding thermochromic character and optical switching properties.

  2. Effect of alloying elements on the stability of Ni2M in Alloy690 based upon thermodynamic calculation

    International Nuclear Information System (INIS)

    Horiuchi, Toshiaki; Kuwano, Kazuhiro; Satoh, Naohiro

    2012-01-01

    Some researchers recently point out that Ni based alloys used in nuclear power plants have the ordering tendency, which is a potential to decrease mechanical properties within the expected lifetime of the plants. In the present study, authors evaluated the effect of 8 alloying elements on the ordering tendency in Alloy690 based upon thermodynamic calculation by Thermo-Calc. It is clarified that the additive amount of Fe, Cr, Ti and Si, particularly Fe and Cr, was influential for the stability of Ni 2 M, while that of Mn, Cu, B and C had almost no effect for that. Authors therefore designed the Ni 2 M stabilized alloy by no addition of Fe in Alloy690. Ni 2 M is estimated to be stable even at 773 K in the Ni 2 M stabilized alloy. The influence by long range ordering or precipitating of Ni 2 M in Alloy690 for mechanical properties or SCC susceptibility is expected to be clarified by the sample obtained in the present study. (author)

  3. Modulation of radiation-induced apoptosis and G{sub 2}/M block in murine T-lymphoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Palayoor, S.T.; Macklis, R.M.; Bump, E.A.; Coleman, C.N. [Harvard Medical School, Boston, MA (United States)

    1995-03-01

    Radiation-induced apoptosis in lymphocyte-derived cell lines is characterized by endonucleolytic cleavage of cellular DNA within hours after radiation exposure. We have studied this phenomenon qualitatively (DNA gel electrophoresis) and quantitatively (diphenylamine reagent assay) in murine EL4 T-lymphoma cells exposed to {sup 137}Cs {gamma} irradiation. Fragmentation was discernible within 18-24 h after exposure. It increased with time and dose and reached a plateau after 8 Gy of {gamma} radiation. We studied the effect of several pharmacological agents on the radiation-induced G{sub 2}/M block and DNA fragmentation. The agents which reduced the radiation-induced G{sub 2}/M-phase arrest (caffeine, theobromine, theophylline and 2-aminopurine) enhanced the degree of DNA fragmentation at 24 h. In contrast, the agents which sustained the radiation-induced G{sub 2}/M-phase arrest (TPA, DBcAMP, IBMX and 3-aminobenzamide) inhibited the DNA fragmentation at 24 h. These studies on EL4 lymphoma cells are consistent with the hypothesis that cells with radiation-induced genetic damage are eliminated by apoptosis subsequent to a G{sub 2}/M block. Furthermore, it may be possible to modulate the process of radiation-induced apoptosis in lymphoma cells with pharmacological agents that modify the radiation-induced G{sub 2}/M block, and to use this effect in the treatment of patients with malignant disease. 59 refs., 7 figs.

  4. BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.

    Science.gov (United States)

    An, Ming-Xin; Li, Si; Yao, Han-Bing; Li, Chao; Wang, Jia-Mei; Sun, Jia; Li, Xin-Yu; Meng, Xiao-Na; Wang, Hua-Qin

    2017-12-04

    Aerobic glycolysis, a phenomenon known historically as the Warburg effect, is one of the hallmarks of cancer cells. In this study, we characterized the role of BAG3 in aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) and its molecular mechanisms. Our data show that aberrant expression of BAG3 significantly contributes to the reprogramming of glucose metabolism in PDAC cells. Mechanistically, BAG3 increased Hexokinase 2 (HK2) expression, the first key enzyme involved in glycolysis, at the posttranscriptional level. BAG3 interacted with HK2 mRNA, and the degree of BAG3 expression altered recruitment of the RNA-binding proteins Roquin and IMP3 to the HK2 mRNA. BAG3 knockdown destabilized HK2 mRNA via promotion of Roquin recruitment, whereas BAG3 overexpression stabilized HK2 mRNA via promotion of IMP3 recruitment. Collectively, our results show that BAG3 promotes reprogramming of glucose metabolism via interaction with HK2 mRNA in PDAC cells, suggesting that BAG3 may be a potential target in the aerobic glycolysis pathway for developing novel anticancer agents. © 2017 An et al.

  5. Modulation of radiation-induced apoptosis and G2/M block in murine T-lymphoma cells

    International Nuclear Information System (INIS)

    Palayoor, S.T.; Macklis, R.M.; Bump, E.A.; Coleman, C.N.

    1995-01-01

    Radiation-induced apoptosis in lymphocyte-derived cell lines is characterized by endonucleolytic cleavage of cellular DNA within hours after radiation exposure. We have studied this phenomenon qualitatively (DNA gel electrophoresis) and quantitatively (diphenylamine reagent assay) in murine EL4 T-lymphoma cells exposed to 137 Cs γ irradiation. Fragmentation was discernible within 18-24 h after exposure. It increased with time and dose and reached a plateau after 8 Gy of γ radiation. We studied the effect of several pharmacological agents on the radiation-induced G 2 /M block and DNA fragmentation. The agents which reduced the radiation-induced G 2 /M-phase arrest (caffeine, theobromine, theophylline and 2-aminopurine) enhanced the degree of DNA fragmentation at 24 h. In contrast, the agents which sustained the radiation-induced G 2 /M-phase arrest (TPA, DBcAMP, IBMX and 3-aminobenzamide) inhibited the DNA fragmentation at 24 h. These studies on EL4 lymphoma cells are consistent with the hypothesis that cells with radiation-induced genetic damage are eliminated by apoptosis subsequent to a G 2 /M block. Furthermore, it may be possible to modulate the process of radiation-induced apoptosis in lymphoma cells with pharmacological agents that modify the radiation-induced G 2 /M block, and to use this effect in the treatment of patients with malignant disease. 59 refs., 7 figs

  6. A semiempirical self-consistent CNDO/2M scheme for calculation of clusters simulating active sites on transition metal oxides

    Energy Technology Data Exchange (ETDEWEB)

    Korsunov, V A; Chuvylkin, N D; Zhidomirov, G M; Kazanskii, V B

    1978-09-01

    The developed CNDO/2M scheme, which allows for the presence of up to five different ''end quasi-atoms'' in a cluster, was implemented in a FORTRAN program and tested in calculation of ScO, ScF, and MnO/sub 4/- systems and of model clusters HOX(OH)/sub 3/ and HOXO/sub 3/ for X = Si and Ti. The calculation results showed that the CNDO/2M scheme is well-suited for qualitative quantum-chemical analysis of intermediate para- and diamagnetic oxygen containing complexes involved in heterogeneous processes catalyzed by TM oxides.

  7. DFT study on oxidation of HS(CH2) m SH ( m = 1-8) in oxidative desulfurization

    Science.gov (United States)

    Song, Y. Z.; Song, J. J.; Zhao, T. T.; Chen, C. Y.; He, M.; Du, J.

    2016-06-01

    Density functional theory was employed for calculation of HS(CH2) m SH ( m = 1-8) and its derivatives at B3LYP method at 6-31++g ( d, p) level. Using eigenvalues of LUMO and HOMO for HS(CH2) m SH, the standard electrode potentials were estimated by a stepwise multiple regression techniques (MLR), and obtained as E° = 1.500 + 7.167 × 10-3 HOMO-0.229 LUMO with high correlation coefficients of 0.973 and F values of 43.973.

  8. E2,M1 multipole mixing ratios in even--even nuclei, A greater than or equal to 152

    International Nuclear Information System (INIS)

    Krane, K.S.

    1975-01-01

    A survey is presented of E2,M1 mixing ratios of gamma-ray transitions in even-even nuclei with mass numbers A greater than or equal to 152. Angular distribution and correlation data from the literature are analyzed in terms of a consistent choice of the phase relationship between the E2 and M1 matrix elements. The cutoff date for the literature was June 1975. Based on an average of the experimental results from the literature, a recommended value of the E2,M1 mixing ratio for each transition is included

  9. Modulation of expression of HLA components at the cell surface induced by anti-β2m reagents

    International Nuclear Information System (INIS)

    Ceppellini, R.; Malavasi, F.; Garotta, G.; Trucco, M.

    1981-01-01

    Antibodies against lymphocyte surface components are able to rearrange profoundly the topography of the cell membrane with a different modulation of surface antigens. Of particular interest is the effect of anti-β2m reagents, which are able to suppress completely the reactivity of epitopes carried by the two chains of the ABC dimers, while the expressivity of other antigens, such as DR, is significantly increased. These results have been obtained with immunoradiobinding under a varity of conditions, thus confirming the validity of the ''bb'' (β2m blanketing) test. (author)

  10. Design concepts and performance tests of the 60 GHz electron cyclotron heating (ECH) system for the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Hoshino, Katsumichi; Yamamoto, Takumi; Kawashima, Hisato; Shibata, Takatoshi; Shibuya, Toshihiro

    1985-11-01

    60 GHz overmoded microwave launch system for the JFT-2M tokamak is described. The basic design concepts, specifications of each microwave component and the results of the performance tests are reported. The transmission of the microwave power is done in the circular TE 01 mode which has a low loss along the overmoded circular transmission components of 33 m in length. The microwave power of 80 - 90 kW, pulse width 100 ms in the circular TE 11 mode is finally launched into the JFT-2M tokamak plasma. (author)

  11. Effects of short term training using resistance maximal workloads in futsal players and cyclist Respuesta a corto plazo al entrenamiento de fuerza máxima en jugadores de fútbol sala y ciclistas

    Directory of Open Access Journals (Sweden)

    J.M. Garcia

    2010-09-01

    Full Text Available The purpose of this study is to elucidate the effects of high intensity-strength training (S in two consecutive days in different athletes. 20 subjects divided in two groups: 11 futsal players of semiprofessional level (FG (22,5±1,4 yr and 9 endurance trained athletes of national level (EG (21±1,3 yr. The intervention was composed by two training sessions (4 sets of 3 repetitions at 8590% of their 1RM in the squat exercise separated by 24h. Two days before the first workout and 9 days after the second workout subjects were measured for 1RM in squat (90 knee angle. Tests: 1 Maximum Repetition in half-squat exercise. Variables: weight in one maximum repetititum (kg; Force (N; and power (w. Instrument: MicromuscleLab Power (ergotest technology as-Norway. The results showed increasing in 1MR in weight (p<0.05, force production ((p<0.05 but didn’t showed significant differences in power output in 1MR It was concluded that acute effects of high intensity strength training using this protocol is advantageous for increasing force production in futsal players and cyclists.

    Key Words:short term effect, strength, power, training program

     

    El objetivo del estudio es conocer los efectos sobre la fuerza máxima y la potencia en 1 repetición máxima (RM de un programa de entrenamiento de fuerza usando cargas máximas en jugadores de fútbol-sala y ciclistas. 20 hombres divididos en 2 grupos: 11 jugadores de fútbol-sala semiprofesionales (21±1,3 años, y 9 ciclistas de ruta de categoría nacional (22,5±1,4 años participaron en la investigación. El programa de entrenamiento fue 2 sesiones (4 series de 3 repeticiones al 85-90% de 1RM, con 3-5 min de descanso entre series, con la máxima velocidad de ejecución posible, posteriormente descansaban 9 días repitiéndose de nuevo este trabajo. Se determinó a través del test 1RM en

  12. Troquel sensorizado para el estudio de las principales fuerzas que intervienen en el proceso de embutición. // Sensitivity Die for the study of the main forces in the rivet process.

    Directory of Open Access Journals (Sweden)

    L. A. Valdivia Pérez

    2006-05-01

    Full Text Available El control de las fuerzas que intervienen en el desarrollo del embutido, así como también en la generación de la fuerza defricción, es una vía para lograr la disminución de los defectos en las piezas y minimizar la fricción. Mediante el empleo dela electrónica moderna y las técnicas de sensorización, como complemento necesario, puede obtenerse un control integraldel proceso.En el presente trabajo se muestra el proceso de diseño y selección de los componentes de un sistema de regulación ycontrol para un troquel que ha sido diseñado y construido con el objetivo de conocer el comportamiento de las principalesfuerzas que intervienen en el proceso de embutición. Como elementos de medición y control de los parámetros del procesose utilizan diversos tipos de sensores o captadores.Palabras claves: Control de fuerzas en el embutido, troquel sensorizado, sistema de control, captador, fricción ydesgaste en troqueles.____________________________________________________________________________Abstract.The control of forces that intervene in the development of the deep drawing process, as well as in the generation of thefriction force it is a way to achieve the decrease of defects in spares, and to minimize friction.The present paper deals with the process of design and selection of components of the regulation and control system for adie designed and build for the analysis of the principal forces in the deep drawing process. Different types of sensors orcollectors have been used in order to allow the control and the measurement of parameters.Keywords: Deep drawing process, control system, captator, friction and wear in die.

  13. Comparison of results of radioimmunoassay performed with nationwide different commercial kits for AFP, CEA, β2-m and TSH

    International Nuclear Information System (INIS)

    Sun Youxiang; Xu Ligen; Jiao Yan; Yang Wenbao; Wei Zekun; Sun Yanmin

    2005-01-01

    Objective: Study on an external quality assessment program with national quality control sera as standard for the comparison of the radioimmunoassay results obtained with different kits for AFP, CEA, β 2 -m and TSH. Methods: National quality control sera as well as pooled 'unknown' clinical sera specimens were assigned to the national laboratory and different manufacturers' laboratories (n=13) to be assayed for AFP, CEA, β 2 -m and TSH and the results cross-checked. Results: With CEA, the coefficient variation (CV) of different sets (n=7) assayed in the national and manufacturers' laboratories ranged from 10-30%; with β 2 -m, the CV ranged 10-20% (sets n=7); with AFP, CV ranged 15% ± (n=6). The above data suggested fairly good comparability and reproducibility. However, the results were less satisfactory with TSH assays (CV 20-40%, n=7). Conclusion: Present study revealed fairly satisfactory quality with CEA, β 2 -m and AFP kits. With TSH kits, the comparability was less satisfactory; the clinical normal ranges in different laboratories should be individualized and internal quality control enforced. (authors)

  14. A Collaboration-Oriented M2M Messaging Mechanism for the Collaborative Automation between Machines in Future Industrial Networks

    Directory of Open Access Journals (Sweden)

    Zhaozong Meng

    2017-11-01

    Full Text Available Machine-to-machine (M2M communication is a key enabling technology for industrial internet of things (IIoT-empowered industrial networks, where machines communicate with one another for collaborative automation and intelligent optimisation. This new industrial computing paradigm features high-quality connectivity, ubiquitous messaging, and interoperable interactions between machines. However, manufacturing IIoT applications have specificities that distinguish them from many other internet of things (IoT scenarios in machine communications. By highlighting the key requirements and the major technical gaps of M2M in industrial applications, this article describes a collaboration-oriented M2M (CoM2M messaging mechanism focusing on flexible connectivity and discovery, ubiquitous messaging, and semantic interoperability that are well suited for the production line-scale interoperability of manufacturing applications. The designs toward machine collaboration and data interoperability at both the communication and semantic level are presented. Then, the application scenarios of the presented methods are illustrated with a proof-of-concept implementation in the PicknPack food packaging line. Eventually, the advantages and some potential issues are discussed based on the PicknPack practice.

  15. Tributyltin induces G2/M cell cycle arrest via NAD(+)-dependent isocitrate dehydrogenase in human embryonic carcinoma cells.

    Science.gov (United States)

    Asanagi, Miki; Yamada, Shigeru; Hirata, Naoya; Itagaki, Hiroshi; Kotake, Yaichiro; Sekino, Yuko; Kanda, Yasunari

    2016-04-01

    Organotin compounds, such as tributyltin (TBT), are well-known endocrine-disrupting chemicals (EDCs). We have recently reported that TBT induces growth arrest in the human embryonic carcinoma cell line NT2/D1 at nanomolar levels by inhibiting NAD(+)-dependent isocitrate dehydrogenase (NAD-IDH), which catalyzes the irreversible conversion of isocitrate to α-ketoglutarate. However, the molecular mechanisms by which NAD-IDH mediates TBT toxicity remain unclear. In the present study, we examined whether TBT at nanomolar levels affects cell cycle progression in NT2/D1 cells. Propidium iodide staining revealed that TBT reduced the ratio of cells in the G1 phase and increased the ratio of cells in the G2/M phase. TBT also reduced cell division cycle 25C (cdc25C) and cyclin B1, which are key regulators of G2/M progression. Furthermore, apigenin, an inhibitor of NAD-IDH, mimicked the effects of TBT. The G2/M arrest induced by TBT was abolished by NAD-IDHα knockdown. Treatment with a cell-permeable α-ketoglutarate analogue recovered the effect of TBT, suggesting the involvement of NAD-IDH. Taken together, our data suggest that TBT at nanomolar levels induced G2/M cell cycle arrest via NAD-IDH in NT2/D1 cells. Thus, cell cycle analysis in embryonic cells could be used to assess cytotoxicity associated with nanomolar level exposure of EDCs.

  16. Superconductivity in dense Mg1–xMxB2 (M= Zr, Nb, Mo; x= 0⋅ 05 ...

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science; Volume 28; Issue 3. Superconductivity in dense Mg1–MB2 (M = Zr, Nb, Mo; = 0.05) materials sintered under pressure. S Kalavathi C Divakar. Superconductors Volume 28 Issue 3 June 2005 pp 249-252 ...

  17. IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development

    Directory of Open Access Journals (Sweden)

    Lars Jønson

    2014-04-01

    Full Text Available The IMP3 RNA-binding protein is associated with metastasis and poor outcome in human cancer. Using solid cancer transcriptome data, we found that IMP3 correlates with HMGA2 mRNA expression. Cytoplasmic IMP3 granules contain HMGA2, and IMP3 dose-dependently increases HMGA2 mRNA. HMGA2 is regulated by let-7, and let-7 antagomiRs make HMGA2 refractory to IMP3. Removal of let-7 target sites eliminates IMP3-dependent stabilization, and IMP3-containing bodies are depleted of Ago1-4 and miRNAs. The relationship between Hmga2 mRNA and IMPs also exists in the developing limb bud, where IMP1-deficient embryos show dose-dependent Hmga2 mRNA downregulation. Finally, IMP3 ribonucleoproteins (RNPs contain other let-7 target mRNAs, including LIN28B, and a global gene set enrichment analysis demonstrates that miRNA-regulated transcripts in general are upregulated following IMP3 induction. We conclude that IMP3 RNPs may function as cytoplasmic safe houses and prevent miRNA-directed mRNA decay of oncogenes during tumor progression.

  18. Magnetism and unconventional superconductivity in CenMmIn3n+2m heavy-fermion crystals

    International Nuclear Information System (INIS)

    Thompson, J.D.; Nicklas, M.; Bianchi, A.; Movshovich, R.; Llobet, A.; Bao, W.; Malinowski, A.; Hundley, M.F.; Moreno, N.O.; Pagliuso, P.G.; Sarrao, J.L.; Nakatsuji, S.; Fisk, Z.; Borth, R.; Lengyel, E.; Oeschler, N.; Sparn, G.; Steglich, F.

    2003-01-01

    We review magnetic, superconducting and non-Fermi-liquid properties of the structurally layered heavy-fermion compounds Ce n M m In 3n+2m (M=Co,Rh,Ir). These properties suggest d-wave superconductivity and proximity to an antiferromagetic quantum-critical point

  19. Factores que influyen en la aceptabilidad del uso de la vasectomía como estrategia para la disminución de embarazos no deseados por parte de miembros de las Fuerzas Militares de Colombia

    OpenAIRE

    Vidal Rivera, Yuly Anjelica; Garzón Cortes, Karen Irene

    2013-01-01

    Este trabajo de tesis se realizó con el objetivo de conocer y determinar, los factores que influyen en la aceptabilidad del uso de la vasectomía, como estrategia para la disminución de embarazos no deseados por parte de miembros de las Fuerzas Armadas de Colombia, buscando una estrategia adecuada para reducir costos del sistema de sanidad militar. Se realizo un estudio de tipo exploratorio - descriptivo con enfoque cuantitativo, en busca de identificar las causas de la baja participación ...

  20. Calidad de vida y cáncer de próstata: un programa progresivo de fuerza-resistencia = Quality of life and prostate cancer: a progressive resistance strength program

    OpenAIRE

    Serdà Ferrer, Bernat-Carles; Monreal i Bosch, Pilar; Valle Gómez, Arantza del

    2011-01-01

    Este artículo presenta el diseño y la implementación de un programa progresivo de fuerza-resistencia adaptado al cáncer de próstata. El modelo base corresponde a la guía de la American College Sports Medicine Position Stand (ACSM, 2009). La adaptación y transformación del programa incluye los síntomas más habituales relativos a la enfermedad y sus tratamientos. El diseño del estudio es cuasiexperimental. La muestra es de 33 participantes en fase de tratamiento. Las variables de estudio so...

  1. Revisión del efecto del entrenamiento de la fuerza sobre el rendimiento de la resistencia y variables asociadas en distintas disciplinas (ciclismo, pedestrismo, triatlón, etc.)

    OpenAIRE

    Cragnulini, Franco Emmanuel

    2015-01-01

    El propósito de la presente revisión será analizar los resultados de distintas investigaciones en relación al tema mencionado con anterioridad y arribar a una conclusión que permita acercarnos a una respuesta de si resulta beneficioso o contraproducente acoplar el entrenamiento de la fuerza al programa de entrenamiento de la resistencia en deportes cíclicos (ciclismo, pedestrismo, triatlón, etc). El entrenamiento de la resistencia disminuye la actividad de las enzimas glucolítica...

  2. Valoración "in vitro" de las fuerzas de adhesión de un sistema adhesivo convencional y otro autograbante en esmalte de dientes temporales y permanentes

    OpenAIRE

    Herrera Martínez, Gilberto de Jesús

    2012-01-01

    El presente trabajo trata de aportar más información sobre un nuevo adhesivo autograbante a esmalte de dientes temporales y permanentes. El objetivo es valorar las fuerzas de adhesión en MPa de los sistemas adhesivos (convencional y autograbante),en el esmalte de dientes temporales y permanentes. Métodos: utilizando una muestra de 160 dientes (temporales y permanentes)a nivel de la estructura del esmalte, divididos en cuatro grupos, no tomándose en cuenta para el criterio de selección la p...

  3. Relación del peso máximo con la fuerza aplicada y la potencia producida en un test creciente, en el ejercicio de press de banca plano con barra libre, en levantadores

    OpenAIRE

    Naclerio Ayllón, Fernando; Jiménez Gutiérrez, Alfonso; Forte Fernández, Daniel; Benito Peinado, Pedro J.

    2006-01-01

    Se evaluaron 9 levantadores que realizaron 2 test, en el ejercicio de press de banca plano con barra libre. Un test progresivo con pesos ligeros a máximos (TPR), y el test de una máxima repetición (1 MRD). Se midió la fuerza (f), velocidad (v) y potencia (p) con cada peso movilizado, se determinó el máximo peso desplazado en una única repetición (1 MR). Se observaron correlaciones significativas entre el valor de la 1 MR obtenida en el test de 1 MRPr y el de 1 MRD, entre la potencia máxima (a...

  4. Riesgos físicos y efectos en la salud del personal de enfermería, que labora en el centro quirúrgico del Hospital de Especialidades Fuerzas Armadas, periodo Marzo 2010 a Marzo 2011

    OpenAIRE

    Montes Hinojosa, Freddy Patricio

    2014-01-01

    El presente estudio se fundamentó, en la investigación bibliográfica y de campo, El tipo de investigación es descriptiva y transversal, se utilizó para la recolección de datos la técnica de la encuesta, con la aplicación de un cuestionario. La población de estudio comprende de 30 talentos humanos, 16 Enfermeras/os y 14 auxiliares e instrumentistas de enfermería que labora en la Sala de Operaciones del Hospital de Especialidades Fuerzas Armadas. La naturaleza del trabajo de enfermería expone a...

  5. Influencia de la masa corporal y de la distribución grasa sobre la fuerza muscular de una cohorte de población anciana: Diferencias por sexo

    OpenAIRE

    Castillo Gallego, Carmen

    2015-01-01

    Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura 18-09-2015 Objetivo: La grasa visceral tiene una alta actividad metabólica con efectos deletéreos para la salud. Entre los efectos adversos contra la salud está el aumento del riesgo de fragilidad. Una parte importante de la fragilidad en el anciano es la sarcopenia o pérdida de masa y de fuerza muscular que se produce con la edad. En esta tesis do...

  6. Valoración de la influencia de la práctica del fútbol en la evolución de la fuerza, la flexibilidad y la velocidad en población infantil

    OpenAIRE

    Silvia Sedano Campo*; Gonzalo Cuadrado Sáenz; uan Carlos Redondo Castán

    2007-01-01

    El objetivo del estudio es valorar la influencia que la práctica regular del fútbol tiene sobre algunos aspectos de la condición física (fuerza explosiva del tren inferior, flexibilidad y velocidad) en niños de entre 7 y 14 años. Por otro lado también pretendemos determinar la correlación existente entre las tres capacidades evaluadas, comparar los resultados con población infantil general y analizar las posibles influencias que la práctica de este deporte puede tener en el desarrollo evoluti...

  7. Política pública sobre capacitación y empleo en Chile: Inclusión/exclusión de una fuerza laboral que envejece

    OpenAIRE

    Gray, Nora; Basualto, Cynthia; Sisto, Vicente

    2017-01-01

    Resumen: Nuestra sociedad está envejeciendo, muchas personas se verán obligados a trabajar hasta avanzada edad. Desde el punto de vista laboral, se requieren de políticas públicas inclusivas de la fuerza laboral a medida que envejece ofreciendo oportunidades de capacitación y fomento del empleo. Este estudio exploratorio analizó la oferta de los programas vigentes del Servicio Nacional de Capacitación y Empleo respecto a si promueven o no la inclusión de trabajadores mayores. Se realizó una c...

  8. Desarrollo de la fuerza en la lucha olímpica categoría cadetes 15-17 años de la Selección del Azuay

    OpenAIRE

    Guerrero García, René Santiago; Tapia Paredes, Bolívar Alfonso

    2011-01-01

    Los orígenes de la lucha se han dado desde la aparición del hombre ya que se viene dando en competencias desde las primeras olimpiadas antiguas y modernas. En nuestro país la lucha como tal se introduce a mediados del siglo pasado en ciudades como Quito y Guayaquil que son las pioneras de esta disciplina, y a la ciudad de Cuenca se introduce en los años setenta. Los métodos utilizados para el desarrollo de la fuerza son los Generales y Específicos. La característica de esta cualidad fí...

  9. Masa muscular, fuerza isométrica y dinámica en las extremidades inferiores de niños y adolescentes con síndrome de Down

    OpenAIRE

    González-Agüero, A.; Villarroya, M.A.; Vicente-Rodríguez, G.; Casajús, J.A.

    2009-01-01

    En general se ha observado que las personas con síndrome de Down (SD) tienen valores inferiores de fuerza muscular comparados con personas sin SD. También existe un déficit de masa muscular en los adultos con SD comparados con otros sin SD. Sin embargo, ningún estudio hasta la fecha había evaluado esta masa muscular en población pediátrica. Nuestro estudio pretende poner de manifiesto si también a edades tempranas existe un déficit de masa muscular y además relacionar ambos valores. Los niños...

  10. ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.

    Science.gov (United States)

    Kolb, Ryan H; Greer, Patrick M; Cao, Phu T; Cowan, Kenneth H; Yan, Ying

    2012-01-01

    Topo II poisons, which target topoisomerase II (topo II) to generate enzyme mediated DNA damage, have been commonly used for anti-cancer treatment. While clinical evidence demonstrate a capability of topo II poisons in inducing apoptosis in cancer cells, accumulating evidence also show that topo II poison treatment frequently results in cell cycle arrest in cancer cells, which was associated with subsequent resistance to these treatments. Results in this report indicate that treatment of MCF-7 and T47D breast cancer cells with topo II poisons resulted in an increased phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and an subsequent induction of G2/M cell cycle arrest. Furthermore, inhibition of ERK1/2 activation using specific inhibitors markedly attenuated the topo II poison-induced G2/M arrest and diminished the topo II poison-induced activation of ATR and Chk1 kinases. Moreover, decreased expression of ATR by specific shRNA diminished topo II poison-induced G2/M arrest but had no effect on topo II poison-induced ERK1/2 activation. In contrast, inhibition of ERK1/2 signaling had little, if any, effect on topo II poison-induced ATM activation. In addition, ATM inhibition by either incubation of cells with ATM specific inhibitor or transfection of cells with ATM specific siRNA did not block topo II poison-induced G2/M arrest. Ultimately, inhibition of ERK1/2 signaling greatly enhanced topo II poison-induced apoptosis. These results implicate a critical role for ERK1/2 signaling in the activation of G2/M checkpoint response following topo II poison treatment, which protects cells from topo II poison-induced apoptosis.

  11. Fuerzas concurrentes en la conformación de la identidad profesional de los psicólogos Concurrent powers to build up the professional identity of psychologists

    Directory of Open Access Journals (Sweden)

    Ana Diamant

    2006-12-01

    Full Text Available Se propone la recuperación de una historia de creencias, valores y representaciones de estudiantes y docentes de Psicología de la UBA, en relación a la consolidación del perfil académico y profesional de los graduados y a los actores y fuerzas que operaron en los primeros tiempos que suceden a la creación de la carrera. Para su elaboración se atendieron cuestiones vinculadas a las características de •el contenido: una versión del pasado, atravesada por el tiempo y condicionada por la posición que protagonistas y testigos ocuparon o que se les atribuyen. •lo metodológico: las maniobras para la consolidación, interpelación e interpretación de fuentes. •los escenarios donde se desplegaron las acciones. las actuaciones tanto individuales como grupales y a las relaciones establecidas. •el sello que dejaron los primeros maestros y protagonistas reconocidos al tiempo que se ocupaban los espacios de formación, inserción profesional y gremial.The purpose is the recovery of a history of beliefs, values and representations of students and professors of the course of studies of psychology at UBA which might be related with the graduates' professional and academic profile and with the protagonists and powers that influenced it at the beginning of the course of studies. In order to do so, we took into account all those matters related to the following: •Content: a version of the past, influenced by time and conditioned by the role protagonists and witnesses played or the one that was granted to them. •Methodology: maneuvers for the consolidation, questioning and interpretation of sources. •The scenes where the events occurred. Individual and team roles and the relationships among them. •The hallmarks of the first recognized professors and protagonists when dealing with training, professional and guild inclusion spaces.

  12. Optimum design of a self-supported power transmission tower type 2M2 for 230 kW; Diseno optimo de una torre de transmision autosoportada tipo 2M2, para 230 kW

    Energy Technology Data Exchange (ETDEWEB)

    Espejel Valdez, Eduardo [Instituto de Investigaciones Electricas, Cuernavaca (Mexico); Millan Monje, Alejandro; Honk Hernandez, Wenceslao [Comision Federal de Electricidad, (CFE), Mexico, D. F. (Mexico)

    1986-12-31

    A group of specialists from the Comision Federal de Electricidad (CFE) and of the Instituto de Investigaciones Electricas (IIE) analyzes the design of various types of power transmission towers in their application stage, in order to enhance them. In this article the structural characteristics of the self-supported tower type 2M2 for 230 kV of two circuits and of suspension, are presented. [Espanol] Un grupo de especialistas de la Comision Federal de Electricidad (CFE) y del Instituto de Investigaciones Electricas (IIE) analiza el diseno de diversos tipos de torres de transmision en su etapa de aplicacion, con el fin de mejorarlos. En este articulo se presentan las caracteristicas estructurales de la torre autosoportada tipo 2M2 para 230 kV, de dos circuitos y de suspension.

  13. Optimum design of a self-supported power transmission tower type 2M2 for 230 kW; Diseno optimo de una torre de transmision autosoportada tipo 2M2, para 230 kW

    Energy Technology Data Exchange (ETDEWEB)

    Espejel Valdez, Eduardo [Instituto de Investigaciones Electricas, Cuernavaca (Mexico); Millan Monje, Alejandro; Honk Hernandez, Wenceslao [Comision Federal de Electricidad, (CFE), Mexico, D. F. (Mexico)

    1985-12-31

    A group of specialists from the Comision Federal de Electricidad (CFE) and of the Instituto de Investigaciones Electricas (IIE) analyzes the design of various types of power transmission towers in their application stage, in order to enhance them. In this article the structural characteristics of the self-supported tower type 2M2 for 230 kV of two circuits and of suspension, are presented. [Espanol] Un grupo de especialistas de la Comision Federal de Electricidad (CFE) y del Instituto de Investigaciones Electricas (IIE) analiza el diseno de diversos tipos de torres de transmision en su etapa de aplicacion, con el fin de mejorarlos. En este articulo se presentan las caracteristicas estructurales de la torre autosoportada tipo 2M2 para 230 kV, de dos circuitos y de suspension.

  14. [H2en]2{La2M(SO4)6(H2O)2} (M=Co, Ni): First organically templated 3d-4f mixed metal sulfates

    International Nuclear Information System (INIS)

    Yuan Yanping; Wang Ruiyao; Kong Deyuan; Mao Jianggao; Clearfield, Abraham

    2005-01-01

    The first organically templated 3d-4f mixed metal sulfates, [H 2 en] 2 {La 2 M(SO 4 ) 6 (H 2 O) 2 } (M=Co 1, Ni 2) have been synthesized and structurally determined from non-merohedrally twinned crystals. The two compounds are isostructural and their structures feature a three-dimensional anionic network formed by the lanthanum(III) and nickel(II) ions bridged by sulfate anions. The La(III) ions in both compounds are 10-coordinated by four sulfate anions in bidentate chelating fashion, and two sulfate anions in a unidentate fashion. The transition metal(II) ion is octahedrally coordinated by six oxygens from four sulfate anions and two aqua ligands. The doubly protonated enthylenediamine cations are located at the tunnels formed by 8-membered rings (four La and four sulfate anions)

  15. Preserving Smart Objects Privacy through Anonymous and Accountable Access Control for a M2M-Enabled Internet of Things

    Directory of Open Access Journals (Sweden)

    José L. Hernández-Ramos

    2015-07-01

    Full Text Available As we get into the Internet of Things era, security and privacy concerns remain as the main obstacles in the development of innovative and valuable services to be exploited by society. Given the Machine-to-Machine (M2M nature of these emerging scenarios, the application of current privacy-friendly technologies needs to be reconsidered and adapted to be deployed in such global ecosystem. This work proposes different privacy-preserving mechanisms through the application of anonymous credential systems and certificateless public key cryptography. The resulting alternatives are intended to enable an anonymous and accountable access control approach to be deployed on large-scale scenarios, such as Smart Cities. Furthermore, the proposed mechanisms have been deployed on constrained devices, in order to assess their suitability for a secure and privacy-preserving M2M-enabled Internet of Things.

  16. Preserving Smart Objects Privacy through Anonymous and Accountable Access Control for a M2M-Enabled Internet of Things

    Science.gov (United States)

    Hernández-Ramos, José L.; Bernabe, Jorge Bernal; Moreno, M. Victoria; Skarmeta, Antonio F.

    2015-01-01

    As we get into the Internet of Things era, security and privacy concerns remain as the main obstacles in the development of innovative and valuable services to be exploited by society. Given the Machine-to-Machine (M2M) nature of these emerging scenarios, the application of current privacy-friendly technologies needs to be reconsidered and adapted to be deployed in such global ecosystem. This work proposes different privacy-preserving mechanisms through the application of anonymous credential systems and certificateless public key cryptography. The resulting alternatives are intended to enable an anonymous and accountable access control approach to be deployed on large-scale scenarios, such as Smart Cities. Furthermore, the proposed mechanisms have been deployed on constrained devices, in order to assess their suitability for a secure and privacy-preserving M2M-enabled Internet of Things. PMID:26140349

  17. The interaction between beta 2-microglobulin (beta 2m) and purified class-I major histocompatibility (MHC) antigen

    DEFF Research Database (Denmark)

    Pedersen, L O; Hansen, A S; Olsen, A C

    1994-01-01

    been generated recently and this paper reports on a similar assay for the interaction between beta 2m and class I. As a model system human beta 2m binding to mouse class I was used. The assay is strictly biochemical using purified reagents which interact in solution and complex formation is determined...... by size separation. It is specific and highly sensitive. The observed affinity of the interaction, KD, is close to 0.4 nM. The rate of association at 37 degrees C is very fast (the ka is around 5 x 10(4)/M/s) whereas the dissociation is slow (the kd is around 8 x 10(-6)/s); the ratio of dissociation...

  18. A latency analysis for M2M and OG-like traffic patterns in different HSPA core network configurations

    Directory of Open Access Journals (Sweden)

    M. V. Popović

    2014-11-01

    Full Text Available In this paper we present an analysis intended to reveal possible impacts of core network features on latency for modelled M2M and Online Gaming traffic. Simulations were performed in a live 3G/HSPA network. Test traffic simulating multiplayer real-time games and M2M applications was generated on 10 mobile phones in parallel, sending data to a remote server. APNs with different combinations of hardware and features (proxy server, different GGSNs and firewalls, usage of Service Awareness feature were chosen. The traffic was recorded on the Gn interface in the mobile core. The goal of experiments was to evaluate any eventually significant variation of average recorded RTTs in the core part of mobile network that would clearly indicate either the impact of used APN on delay for a specific traffic pattern, or selectivity of the APN towards different traffic patterns.

  19. Preserving Smart Objects Privacy through Anonymous and Accountable Access Control for a M2M-Enabled Internet of Things.

    Science.gov (United States)

    Hernández-Ramos, José L; Bernabe, Jorge Bernal; Moreno, M Victoria; Skarmeta, Antonio F

    2015-07-01

    As we get into the Internet of Things era, security and privacy concerns remain as the main obstacles in the development of innovative and valuable services to be exploited by society. Given the Machine-to-Machine (M2M) nature of these emerging scenarios, the application of current privacy-friendly technologies needs to be reconsidered and adapted to be deployed in such global ecosystem. This work proposes different privacy-preserving mechanisms through the application of anonymous credential systems and certificateless public key cryptography. The resulting alternatives are intended to enable an anonymous and accountable access control approach to be deployed on large-scale scenarios, such as Smart Cities. Furthermore, the proposed mechanisms have been deployed on constrained devices, in order to assess their suitability for a secure and privacy-preserving M2M-enabled Internet of Things.

  20. ALG-2 knockdown in HeLa cells results in G2/M cell cycle phase accumulation and cell death

    DEFF Research Database (Denmark)

    Høj, Berit Rahbek; la Cour, Peter Jonas Marstrand; Mollerup, Jens

    2009-01-01

    downregulation induces accumulation of HeLa cells in the G2/M cell cycle phase and increases the amount of early apoptotic and dead cells. Caspase inhibition by the pan-caspase inhibitor zVAD-fmk attenuated the increase in the amount of dead cells following ALG-2 downregulation. Thus, our results indicate...... that ALG-2 has an anti-apoptotic function in HeLa cells by facilitating the passage through checkpoints in the G2/M cell cycle phase.......ALG-2 (apoptosis-linked gene-2 encoded protein) has been shown to be upregulated in a variety of human tumors questioning its previously assumed pro-apoptotic function. The aim of the present study was to obtain insights into the role of ALG-2 in human cancer cells. We show that ALG-2...

  1. Sexual phenotype differences in zic2 mRNA abundance in the preoptic area of a protogynous teleost, Thalassoma bifasciatum.

    Directory of Open Access Journals (Sweden)

    Katherine McCaffrey

    Full Text Available The highly conserved members of the zic family of zinc-finger transcription factors are primarily known for their roles in embryonic signaling pathways and regulation of cellular proliferation and differentiation. This study describes sexual phenotype differences in abundances of zic2 mRNA in the preoptic area of the hypothalamus, a region strongly implicated in sexual behavior and function, in an adult teleost, Thalassoma bifasciatum. The bluehead wrasse (Thalassoma bifasciatum is a valuable model for studying neuroendocrine processes because it displays two discrete male phenotypes, initial phase (IP males and territorial, terminal phase (TP males, and undergoes socially-controlled protogynous sex change. Previously generated microarray-based comparisons suggested that zic2 was upregulated in the brains of terminal phase males relative to initial phase males. To further explore this difference, we cloned a 727 bp sequence for neural zic2 from field-collected animals. Riboprobe-based in situ hybridization was employed to localize zic2 signal in adult bluehead brains and assess the relative abundance of brain zic2 mRNA across sexual phenotypes. We found zic2 mRNA expression was extremely abundant in the granular cells of the cerebellum and widespread in other brain regions including in the thalamus, hypothalamus, habenula, torus semicircularis, torus longitudinalis, medial longitudinal fascicle and telencephalic areas. Quantitative autoradiography and phosphorimaging showed zic2 mRNA hybridization signal in the preoptic area of the hypothalamus was significantly higher in terminal phase males relative to both initial phase males and females, and silver grain analysis confirmed this relationship between phenotypes. No significant difference in abundance was found in zic2 signal across phenotypes in the habenula, a brain region not implicated in the control of sexual behavior, or cerebellum.

  2. IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?

    Czech Academy of Sciences Publication Activity Database

    Tomala, Jakub; Kovář, Marek

    2016-01-01

    Roč. 5, č. 3 (2016), e1102829 ISSN 2162-402X R&D Projects: GA ČR GA13-12885S; GA MŠk(CZ) ED1.1.00/02.0109 Institutional support: RVO:61388971 Keywords : Anti-IL-2 mAb * cancer immunotherapy * IL-2 Subject RIV: EE - Microbiology, Virology Impact factor: 7.719, year: 2016

  3. Diseño del manual de certificación de las estaciones reparadoras para la estandarización de procedimientos de mantenimiento de productos aeronáuticos de la Fuerza Aérea Colombiana

    Directory of Open Access Journals (Sweden)

    Ricardo Garzón Monroy

    2006-01-01

    Full Text Available El propósito de esta investigación es señalar la normatividad y procedimientos que se necesitan para elaborar el Manual de Certificación de las Estaciones Reparadoras  para la Estandarización de Procedimientos en el Mantenimiento de Productos Aeronáuticos de la Fuerza Aérea Colombiana, cuyo propósito es certificar los procesos de las estaciones reparadoras y suministrar al personal de la Jefatura Técnica y de los Grupos Técnicos en las diferentes unidades las herramientas que servirán para evaluar periódicamente y/o certificar las estaciones reparadoras en Colombia, que prestan sus servicios de mantenimiento para mejorar los niveles de calidad y generar una operación segura de las aeronaves con las que cuenta la Fuerza Aérea. Asimismo, el uso del manual permitirá al personal de mantenimiento de las aeronaves y sus componentes tener un respaldo técnico en la toma de decisiones amparadas en los distintos procesos de certificación.

  4. Militarización de la Policía y Policización de las Fuerzas Militares. Revisión del fenómeno a nivel internacional y nacional

    Directory of Open Access Journals (Sweden)

    William Guillermo Jímenez

    2011-07-01

    Full Text Available El documento tiene por objeto ofrecer un panorama acerca del doble fenómeno de la militarización de la policía y de la policización de las fuerzas militares en algunos países. Para ello se hace una revisión documental sobre la temática analizando los casos de Alemania, Estados Unidos, México, Brasil, Chile y Colombia. La información analizada permite concluir que la división misional clásica entre Policía y Fuerzas Militares no se está dando en la práctica, debido a factores internos de manejo de orden público, a la organización militar de la Policía desde sus orígenes y a cambios en la concepción acerca de la seguridad y la soberanía de los Estados.

  5. ¿Inserción laboral de las mujeres en América Latina: una fuerza de trabajo secundaria? Women's participation in the labor market in Latin America: a secondary work force?

    Directory of Open Access Journals (Sweden)

    Laís Abramo

    2004-08-01

    Full Text Available El objetivo principal de este texto es discutir la aplicación de la noción de "fuerza de trabajo secundaria" para caracterizar la fuerza da trabajo femenina en América Latina. Esa caracterización, hecha con frecuencia en forma mecánica por un lado corresponde, cada vez menos a la realidad de los hechos, ya que es creciente la participación femenina en el mercado de trabajo, así como la continuidad de sus trayectorias laborales, el número de horas dedicadas al trabajo remunerado, así como su aporte al ingreso familiar y a la superación de la situación de pobreza de un porcentaje importante de hogares. Por otro lado, el texto argumenta que esa caracterización es uno de los elementos centrales en la estructuración de los patrones de discriminación de género que persisten y se reproducen en el mercado de trabajo latinoamericano.This article aims to discuss the concept of "secondary labor force" to characterize female workforce in Latin America. Such characterization corresponds increasingly less to reality, as women's participation in the labor force and the hours dedicated to their paid work continues to grow, as well as their contribution to household income. The article argues that such characterization is one of the core elements of the gender discriminating patterns that persist in Latin American labor market.

  6. Efecto de la hipnosis y la terapia de aceptación y compromiso (ACT en la mejora de la fuerza física en piragüistas

    Directory of Open Access Journals (Sweden)

    Rubén Fernández García

    2004-01-01

    Full Text Available En este experimento simple se evaluó la eficacia diferencial de dos técnicas de intervención psicológica -hipnosis y terapia de aceptación y compromiso (ACT- para la mejora de la fuerza física. Participaron en la investigación 16 deportistas de élite, practicantes de piragüismo. A todos los sujetos se les evaluó el grado de sugestibilidad. A los deportistas tratados con hipnosis se les aplicó una breve técnica de relajación, una fase de inducción, introducción de sugestión post-hipnótica y fase de salida del estado hipnótico. La intervención con ACT se dirigió principalmente a la aceptación de determinados eventos privados y estados corporales, enfocando sus conductas de ejecución en dirección a sus valores. Los resultados mostraron mejoras significativas en ambos grupos de intervención en el número de repeticiones en el ejercicio de remo inclinado. Se hace necesario el desarrollo de posteriores investigaciones para verificar la utilidad de estas técnicas en la mejora de la fuerza física y, por tanto, del rendimiento deportivo.

  7. Relación del peso máximo con la fuerza aplicada y la potencia producida en un test creciente, en el ejercicio de press de banca plano con barra libre, en levantadores

    Directory of Open Access Journals (Sweden)

    Fernando Naclerio Ayllón

    2006-12-01

    Full Text Available Se evaluaron 9 levantadores que realizaron 2 test, en el ejercicio de press de banca plano con barra libre. Un test progresivo con pesos ligeros a máximos (TPR, y el test de una máxima repetición (1 MRD. Se midió la fuerza (f, velocidad (v y potencia (p con cada peso movilizado, se determinó el máximo peso desplazado en una única repetición (1 MR. Se observaron correlaciones significativas entre el valor de la 1 MR obtenida en el test de 1 MRPr y el de 1 MRD, entre la potencia máxima (absoluta y relativa al peso corporal y la 1 MR absoluta y relativa al peso corporal. No se observaron diferencias significativas (p < 0,05 entre el valor de la 1 MR obtenida en el test progresivo (1 MRPr y el alcanzado en el test de 1 MRD. Se acepta la aplicación del test progresivo (TPR para determinar los niveles de f, v, p, el valor de la 1 MR en kg, así como localizar los porcentajes de peso, respecto al nivel de la 1 MR, en donde se alcanzan los valores más altos de potencia mecánica, y estimar las adaptaciones funcionales inducidas por los entrenamientos de fuerza.

  8. Enhancing the Production of D-Mannitol by an Artificial Mutant of Penicillium sp. T2-M10.

    Science.gov (United States)

    Duan, Rongting; Li, Hongtao; Li, Hongyu; Tang, Linhuan; Zhou, Hao; Yang, Xueqiong; Yang, Yabin; Ding, Zhongtao

    2018-05-26

    D-Mannitol belongs to a linear polyol with six-carbon and has indispensable usage in medicine and industry. In order to obtain more efficient D-mannitol producer, this study has screened out a stable mutant Penicillium sp. T2-M10 that was isolated from the initial D-mannitol-produced strain Penicillium sp.T2-8 via UV irradiation as well as nitrosoguanidine (NTG) induction. The mutant had a considerable enhancement in yield of D-mannitol based on optimizing fermentation. The production condition was optimized as the PDB medium with 24 g/L glucose for 9 days. The results showed that the production of D-mannitol from the mutant strain T2-M10 increased 125% in contrast with the parental strain. Meanwhile, the fact that D-mannitol is the main product in the mutant simplified the process of purification. Our finding revealed the potential value of the mutant strain Penicillium sp. T2-M10 to be a D-mannitol-producing strain.

  9. A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells.

    Science.gov (United States)

    Hegde, Mahesh; Vartak, Supriya V; Kavitha, Chandagirikoppal V; Ananda, Hanumappa; Prasanna, Doddakunche S; Gopalakrishnan, Vidya; Choudhary, Bibha; Rangappa, Kanchugarakoppal S; Raghavan, Sathees C

    2017-05-31

    Chemically synthesized small molecules play important role in anticancer therapy. Several chemical compounds have been reported to damage the DNA, either directly or indirectly slowing down the cancer cell progression by causing a cell cycle arrest. Direct or indirect reactive oxygen species formation causes DNA damage leading to cell cycle arrest and subsequent cell death. Therefore, identification of chemically synthesized compounds with anticancer potential is important. Here we investigate the effect of benzothiazole derivative (5g) for its ability to inhibit cell proliferation in different cancer models. Interestingly, 5g interfered with cell proliferation in both, cell lines and tumor cells leading to significant G2/M arrest. 5g treatment resulted in elevated levels of ROS and subsequently, DNA double-strand breaks (DSBs) explaining observed G2/M arrest. Consistently, we observed deregulation of many cell cycle associated proteins such as CDK1, BCL2 and their phosphorylated form, CyclinB1, CDC25c etc. Besides, 5g treatment led to decreased levels of mitochondrial membrane potential and activation of apoptosis. Interestingly, 5g administration inhibited tumor growth in mice without significant side effects. Thus, our study identifies 5g as a potent biochemical inhibitor to induce G2/M phase arrest of the cell cycle, and demonstrates its anticancer properties both ex vivo and in vivo.

  10. In Candida albicans hyphae, Sec2p is physically associated with SEC2 mRNA on secretory vesicles.

    Science.gov (United States)

    Caballero-Lima, David; Hautbergue, Guillaume M; Wilson, Stuart A; Sudbery, Peter E

    2014-11-01

    Candida albicans hyphae grow in a highly polarized fashion from their tips. This polarized growth requires the continuous delivery of secretory vesicles to the tip region. Vesicle delivery depends on Sec2p, the Guanine Exchange Factor (GEF) for the Rab GTPase Sec4p. GTP bound Sec4p is required for the transit of secretory vesicles from the trans-Golgi to sites of polarized growth. We previously showed that phosphorylation of Sec2p at residue S584 was necessary for Sec2p to support hyphal, but not yeast growth. Here we show that on secretory vesicles SEC2 mRNA is physically associated with Sec2p. Moreover, we show that the phosphorylation of S584 allows SEC2 mRNA to dissociate from Sec2p and we speculate that this is necessary for Sec2p function and/or translation. During hyphal extension, the growing tip may be separated from the nucleus by up to 15 μm. Transport of SEC2 mRNA on secretory vesicles to the tip localizes SEC2 translation to tip allowing a sufficient accumulation of this key protein at the site of polarized growth. © 2014 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.

  11. Te and ne profiles on JFT-2M plasma with the highest spatial resolution TV Thomson scattering system

    International Nuclear Information System (INIS)

    Yamauchi, T.

    1993-01-01

    A high spatial resolution TV Thomson scattering system was constructed on JFT-2M tokamak. This system is similar to those used at PBX-M and TFTR. These systems are providing complete profiles of Te and ne at a single time during a plasma discharge. The characteristics of JFT-2M TVTS are as follows: 1. Measured points are composed of not only 81 points for the scattered light and plasma light, whose time difference is 2 ms, but also 10 points for plasma light measured at the same time with scattered light. 2. Spatial resolution is 0.86 cm, which is higher than any other Thomson scattering system. 3. Sensitivity of detector composed of image intensifier tubes and CCD is as high as that of photomultiplier tube. Te and ne profiles have been measured over one year on JFT-2M. The line-averaged electron density measured was in the region of 5x10 12 cm -3 - 7x10 13 cm -3 and the measured electron temperature was in the region of 50 eV -1.2 keV. (author) 7 refs., 7 figs., 1 tab

  12. Systematic Investigation of Expression of G2/M Transition Genes Reveals CDC25 Alteration in Nonfunctioning Pituitary Adenomas.

    Science.gov (United States)

    Butz, Henriett; Németh, Kinga; Czenke, Dóra; Likó, István; Czirják, Sándor; Zivkovic, Vladimir; Baghy, Kornélia; Korbonits, Márta; Kovalszky, Ilona; Igaz, Péter; Rácz, Károly; Patócs, Attila

    2017-07-01

    Dysregulation of G1/S checkpoint of cell cycle has been reported in pituitary adenomas. In addition, our previous finding showing that deregulation of Wee1 kinase by microRNAs together with other studies demonstrating alteration of G2/M transition in nonfunctioning pituitary adenomas (NFPAs) suggest that G2/M transition may also be important in pituitary tumorigenesis. To systematically study the expression of members of the G2/M transition in NFPAs and to investigate potential microRNA (miRNA) involvement. Totally, 80 NFPA and 14 normal pituitary (NP) tissues were examined. Expression of 46 genes encoding members of the G2/M transition was profiled on 34 NFPA and 10 NP samples on TaqMan Low Density Array. Expression of CDC25A and two miRNAs targeting CDC25A were validated by individual quantitative real time PCR using TaqMan assays. Protein expression of CDC25A, CDC25C, CDK1 and phospho-CDK1 (Tyr-15) was investigated on tissue microarray and immunohistochemistry. Several genes' expression alteration were observed in NFPA compared to normal tissues by transcription profiling. On protein level CDC25A and both the total and the phospho-CDK1 were overexpressed in adenoma tissues. CDC25A correlated with nuclear localized CDK1 (nCDK1) and with tumor size and nCDK1 with Ki-67 index. Comparing primary vs. recurrent adenomas we found that Ki-67 proliferation index was higher and phospho-CDK1 (inactive form) was downregulated in recurrent tumors compared to primary adenomas. Investigating the potential causes behind CDC25A overexpression we could not find copy number variation at the coding region nor expression alteration of CDC25A regulating transcription factors however CDC25A targeting miRNAs were downregulated in NFPA and negatively correlated with CDC25A expression. Our results suggest that among alterations of G2/M transition of the cell cycle, overexpression of the CDK1 and CDC25A may have a role in the pathogenesis of the NFPA and that CDC25A is potentially

  13. The europium and praseodymium hydrolysis in a 2M NaCl environment; La hidrolisis del europio y del praseodimio en un medio 2M de NaCl

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez R, M.; Lopez G, H.; Solache R, M.; Rojas H, A. [Instituto Nacional de Investigaciones Nucleares, Departamento de quimica, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1998-07-01

    It was studied the europium and praseodymium hydrolysis in a 2M NaCl ion force environment at 303 K, through two methods: this one extraction with dissolvents (lanthanide-water-NaCl-dibenzoylmethane) in presence of a competitive ligand (diglycolic acid) and that one direct potentiometric titration, of soluble species, followed by a computer refining. The values of one or another techniques of the first hydrolysis constants obtained were similar, which demonstrates that the results are reliable. The set of data obtained on the stability constants of hydrolysis products allowed to draw up the distribution diagrams of chemical species, as europium as praseodymium in aqueous environment. (Author)

  14. La fuerza ilocutiva en los debates medievales castellanos de controversia y su plasmación lingüística

    Directory of Open Access Journals (Sweden)

    Elena LEAL ABAD

    2008-10-01

    Full Text Available La presencia de actos de habla indirectos en algunas tipologías de diálogos literarios medievales, especialmente en los que presentan un carácter didáctico-moralizante, no siempre obedece a la noción de cortesía. El espíritu de controversia de estos textos origina que la falta de coincidencia entre modalidad del enunciado y modalidad de la enunciación se relacione con un deseo de distanciamiento dialéctico entre los personajes de la interacción, que tratan de socavar la imagen del interlocutor a través de enunciados que pretenden deslegitimar, ridiculizar o descalificar al adversario. Estos valores descorteses de los enunciados interrogativos derivan fundamentalmente del propio contenido proposicional aunque también constituyen indicios importantes la asimetría de los personajes que intervienen y las propias características del género discursivo. No obstante, en este mismo contexto aparecen mecanismos que tratan de contrarrestar la fuerza ilocutiva de estos actos descorteses minimizando el desacuerdo. En las páginas que siguen se tratará de determinar qué formas y estrategias lingüísticas se adoptan para acometer este tipo de actos y su relación con estructuras propias de la interacción comunicativa con el objetivo de captar una posible evolución de recursos o constancia de los mismos a lo largo de la historia del español.La présence d'actes de langage indirects dans certaines typologies de dialogues littéraires médiévaux, en particulier dans ceux qui présentent un caractère didactico-moralisant, n'obéit pas toujours à la notion de courtoisie. L'esprit de polémique de ces textes engendre la mise en relation du manque de coïncidence entre modalité de l'énoncé et modalité de l'énonciation et d’un désir d'éloignement dialectique entre les personnages de l'interaction, qui essayent de miner l'image de l'interlocuteur au travers d’énoncés qui prétendent délégitimer, ridiculiser ou discréditer l

  15. From WSN towards WoT: Open API Scheme Based on oneM2M Platforms

    Science.gov (United States)

    Kim, Jaeho; Choi, Sung-Chan; Ahn, Il-Yeup; Sung, Nak-Myoung; Yun, Jaeseok

    2016-01-01

    Conventional computing systems have been able to be integrated into daily objects and connected to each other due to advances in computing and network technologies, such as wireless sensor networks (WSNs), forming a global network infrastructure, called the Internet of Things (IoT). To support the interconnection and interoperability between heterogeneous IoT systems, the availability of standardized, open application programming interfaces (APIs) is one of the key features of common software platforms for IoT devices, gateways, and servers. In this paper, we present a standardized way of extending previously-existing WSNs towards IoT systems, building the world of the Web of Things (WoT). Based on the oneM2M software platforms developed in the previous project, we introduce a well-designed open API scheme and device-specific thing adaptation software (TAS) enabling WSN elements, such as a wireless sensor node, to be accessed in a standardized way on a global scale. Three pilot services are implemented (i.e., a WiFi-enabled smart flowerpot, voice-based control for ZigBee-connected home appliances, and WiFi-connected AR.Drone control) to demonstrate the practical usability of the open API scheme and TAS modules. Full details on the method of integrating WSN elements into three example systems are described at the programming code level, which is expected to help future researchers in integrating their WSN systems in IoT platforms, such as oneM2M. We hope that the flexibly-deployable, easily-reusable common open API scheme and TAS-based integration method working with the oneM2M platforms will help the conventional WSNs in diverse industries evolve into the emerging WoT solutions. PMID:27782058

  16. From WSN towards WoT: Open API Scheme Based on oneM2M Platforms

    Directory of Open Access Journals (Sweden)

    Jaeho Kim

    2016-10-01

    Full Text Available Conventional computing systems have been able to be integrated into daily objects and connected to each other due to advances in computing and network technologies, such as wireless sensor networks (WSNs, forming a global network infrastructure, called the Internet of Things (IoT. To support the interconnection and interoperability between heterogeneous IoT systems, the availability of standardized, open application programming interfaces (APIs is one of the key features of common software platforms for IoT devices, gateways, and servers. In this paper, we present a standardized way of extending previously-existing WSNs towards IoT systems, building the world of the Web of Things (WoT. Based on the oneM2M software platforms developed in the previous project, we introduce a well-designed open API scheme and device-specific thing adaptation software (TAS enabling WSN elements, such as a wireless sensor node, to be accessed in a standardized way on a global scale. Three pilot services are implemented (i.e., a WiFi-enabled smart flowerpot, voice-based control for ZigBee-connected home appliances, and WiFi-connected AR.Drone control to demonstrate the practical usability of the open API scheme and TAS modules. Full details on the method of integrating WSN elements into three example systems are described at the programming code level, which is expected to help future researchers in integrating their WSN systems in IoT platforms, such as oneM2M. We hope that the flexibly-deployable, easily-reusable common open API scheme and TAS-based integration method working with the oneM2M platforms will help the conventional WSNs in diverse industries evolve into the emerging WoT solutions.

  17. Role of polyamines at the G1/S boundary and G2/M phase of the cell cycle.

    Science.gov (United States)

    Yamashita, Tomoko; Nishimura, Kazuhiro; Saiki, Ryotaro; Okudaira, Hiroyuki; Tome, Mayuko; Higashi, Kyohei; Nakamura, Mizuho; Terui, Yusuke; Fujiwara, Kunio; Kashiwagi, Keiko; Igarashi, Kazuei

    2013-06-01

    The role of polyamines at the G1/S boundary and in the G2/M phase of the cell cycle was studied using synchronized HeLa cells treated with thymidine or with thymidine and aphidicolin. Synchronized cells were cultured in the absence or presence of α-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, plus ethylglyoxal bis(guanylhydrazone) (EGBG), an inhibitor of S-adenosylmethionine decarboxylase. When polyamine content was reduced by treatment with DFMO and EGBG, the transition from G1 to S phase was delayed. In parallel, the level of p27(Kip1) was greatly increased, so its mechanism was studied in detail. Synthesis of p27(Kip1) was stimulated at the level of translation by a decrease in polyamine levels, because of the existence of long 5'-untranslated region (5'-UTR) in p27(Kip1) mRNA. Similarly, the transition from the G2/M to the G1 phase was delayed by a reduction in polyamine levels. In parallel, the number of multinucleate cells increased by 3-fold. This was parallel with the inhibition of cytokinesis due to an unusual distribution of actin and α-tubulin at the M phase. Since an association of polyamines with chromosomes was not observed by immunofluorescence microscopy at the M phase, polyamines may have only a minor role in structural changes of chromosomes at the M phase. In general, the involvement of polyamines at the G2/M phase was smaller than that at the G1/S boundary. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest.

    Science.gov (United States)

    Lan, Qiusheng; Li, Shoufeng; Lai, Wei; Xu, Heyang; Zhang, Yang; Zeng, Yujie; Lan, Wenjian; Chu, Zhonghua

    2015-08-17

    The potential anti-neoplastic activity of terpenoids is of continued interest. In this study, we investigate whether methyl sartortuoate, a terpenoid isolated from soft coral, induced cell cycle arrest and apoptosis in a human colon cancer cell line. Culture studies found that methyl sartortuoate inhibited colon cancer cell (LoVo and RKO) growth and caused apoptotic death in a concentration- and time-dependent manner, by activation of caspase-8, caspase-9, caspase-3, p53 and Bax, and inactivation of B-cell lymphoma 2 (Bcl-2) apoptosis regulating proteins. Methyl sartortuoate treatment led to reduced expression of cdc2 and up-regulated p21 and p53, suggesting that Methyl sartortuoate induced G2-M arrest through modulation of p53/p21/cdc2 pathways. Methyl sartortuoate also up-regulated phospho-JNK and phospho-p38 expression levels. This resulted in cell cycle arrest at the G2-M phase and apoptosis in LoVo and RKO cells. Treatment with the JNK inhibitor SP600125 and the p38 MAPK inhibitor SB203580 prevented methyl sartortuoate-induced apoptosis in LoVo cells. Moreover, methyl sartortuoate also prevented neoplasm growth in NOD-SCID nude mice inoculated with LoVo cells. Taken together, these findings suggest that methyl sartortuoate is capable of leading to activation of caspase-8, -9, -3, increasing p53 and Bax/Bcl-2 ratio apoptosis through MAPK-dependent apoptosis and results in G2-M phase arrest in LoVo and RKO cells. Thus, methyl sartortuoate may be a promising anticancer candidate.

  19. From WSN towards WoT: Open API Scheme Based on oneM2M Platforms.

    Science.gov (United States)

    Kim, Jaeho; Choi, Sung-Chan; Ahn, Il-Yeup; Sung, Nak-Myoung; Yun, Jaeseok

    2016-10-06

    Conventional computing systems have been able to be integrated into daily objects and connected to each other due to advances in computing and network technologies, such as wireless sensor networks (WSNs), forming a global network infrastructure, called the Internet of Things (IoT). To support the interconnection and interoperability between heterogeneous IoT systems, the availability of standardized, open application programming interfaces (APIs) is one of the key features of common software platforms for IoT devices, gateways, and servers. In this paper, we present a standardized way of extending previously-existing WSNs towards IoT systems, building the world of the Web of Things (WoT). Based on the oneM2M software platforms developed in the previous project, we introduce a well-designed open API scheme and device-specific thing adaptation software (TAS) enabling WSN elements, such as a wireless sensor node, to be accessed in a standardized way on a global scale. Three pilot services are implemented (i.e., a WiFi-enabled smart flowerpot, voice-based control for ZigBee-connected home appliances, and WiFi-connected AR.Drone control) to demonstrate the practical usability of the open API scheme and TAS modules. Full details on the method of integrating WSN elements into three example systems are described at the programming code level, which is expected to help future researchers in integrating their WSN systems in IoT platforms, such as oneM2M. We hope that the flexibly-deployable, easily-reusable common open API scheme and TAS-based integration method working with the oneM2M platforms will help the conventional WSNs in diverse industries evolve into the emerging WoT solutions.

  20. Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats

    Directory of Open Access Journals (Sweden)

    Melissa N. van Tok

    2017-08-01

    Full Text Available Spondyloarthritis (SpA does not display the typical features of auto-immune disease. Despite the strong association with MHC class I, CD8+ T cells are not required for disease induction in the HLA-B27/Huβ2m transgenic rats. We used Lewis HLA-B27/Huβ2m transgenic rats [21-3 × 283-2]F1, HLA-B7/Huβ2m transgenic rats [120-4 × 283-2]F1, and wild-type rats to test our hypothesis that SpA may be primarily driven by the innate immune response. In vitro, splenocytes were stimulated with heat-inactivated Mycobacterium tuberculosis and cytokine expression and production was measured. In vivo, male and female rats were immunized with 30, 60, or 90 µg of heat-inactivated M. tuberculosis and clinically monitored for spondylitis and arthritis development. After validation of the model, we tested whether prophylactic and therapeutic TNF targeting affected spondylitis and arthritis. In vitro stimulation with heat-inactivated M. tuberculosis strongly induced gene expression of pro-inflammatory cytokines such as TNF, IL-6, IL-1α, and IL-1β, in the HLA-B27 transgenic rats compared with controls. In vivo immunization induced an increased spondylitis and arthritis incidence and an accelerated and synchronized onset of spondylitis and arthritis in HLA-B27 transgenic males and females. Moreover, immunization overcame the protective effect of orchiectomy. Prophylactic TNF targeting resulted in delayed spondylitis and arthritis development and reduced arthritis severity, whereas therapeutic TNF blockade did not affect spondylitis and arthritis severity. Collectively, these data indicate that innate immune activation plays a role in the initiation of HLA-B27-associated disease and allowed to establish a useful in vivo model to study the cellular and molecular mechanisms of disease initiation and progression.

  1. Respuesta hemodinámica con el entrenamiento en resistencia y fuerza muscular de miembros superiores en rehabilitación cardiaca Hemodynamic response to training in resistance and muscular strength of upper limbs in cardiac rehabilitation

    Directory of Open Access Journals (Sweden)

    Diana M Camargo

    2007-08-01

    Full Text Available Antecedentes: el entrenamiento de la fuerza muscular en pacientes con eventos cardiovasculares, estaba totalmente contraindicado por el riesgo de incrementar las cifras de tensión arterial sistólica y diastólica, así como someter al miocardio a una sobrecarga. Objetivo: valorar la respuesta hemodinámica (frecuencia cardiaca, tensión arterial durante el entrenamiento de resistencia a la fuerza muscular en los pacientes que asisten a un programa de rehabilitación cardiaca. Diseño: cuasi experimental prospectivo. Excenario: se realizó un entrenamiento de resistencia a la fuerza muscular en miembros superiores a pacientes durante la fase II de rehabilitación cardiaca. Sujetos: se incluyeron 175 pacientes, 135 hombres y 40 mujeres con un promedio de edad de 58,79 años, los cuales presentaron enfermedad coronaria con y sin procedimientos de revascularización, cirugía de cambios valvulares, síncope y corrección quirúrgica de anomalías congénitas. Procedimiento: previo entrenamiento aeróbico (en banda sinfín o bicicleta estática, se realizó la valoración de fuerza muscular mediante una máxima repetición y se inició el entrenamiento de fuerza a 30%-50% de ésta, en circuito de tres ejercicios diferentes en miembros superiores, 10 repeticiones en tres series y frecuencia de dos veces por semana. Se realizó, además, monitoría de la frecuencia cardiaca y electrocardiograma por telemetría (V5, toma de presión arterial antes, durante y después de la sesión, y percepción subjetiva del esfuerzo por escala de Borg, y se observaron signos y síntomas de intolerancia a la actividad o descompensación. Para el análisis estadístico, se utilizaron medidas de tendencia central con los cambios cardiovasculares, y para comparar el cambio en la fuerza muscular, se utilizó una prueba de t pareada con un nivel de significancia de 0,05. Resultados: la fuerza muscular medida con la máxima repetición, evidenció un aumento significativo

  2. World's largest DC flywheel generator for the toroidal field power supply of JAERI's JFT-2M Tokamak nuclear fusion reactor

    International Nuclear Information System (INIS)

    Tani, Takashi; Nakanishi, Yuji; Horita, Tsuyoshi; Kawase, Chiharu; Oyabu, Isao; Kishimoto, Takeshi.

    1996-01-01

    Mitsubishi Electric has delivered the world's largest DC generator for the toroidal field coil power supply of the JFT-2M Tokamak at the Japan Atomic Energy Research Institute. The unit rotates at 225 or 460 rpm, providing a maximum rated output of 2,700 V, 19,000 A and 51.3 MW. The toroidal field is a DC field, so use of a DC generator permits a simpler design consuming less floor space than an AC drive system. The generator was manufactured following extensive studies on commutation, mechanical strength and insulation. (author)

  3. Model validation for radial electric field excitation during L-H transition in JFT-2M tokamak

    Science.gov (United States)

    Kobayashi, T.; Itoh, K.; Ido, T.; Kamiya, K.; Itoh, S.-I.; Miura, Y.; Nagashima, Y.; Fujisawa, A.; Inagaki, S.; Ida, K.; Hoshino, K.

    2017-07-01

    In this paper, we elaborate the electric field excitation mechanism during the L-H transition in the JFT-2M tokamak. Using time derivative of the Poisson’s equation, models of the radial electric field excitation is examined. The sum of the loss-cone loss current and the neoclassical bulk viscosity current is found to behave as the experimentally evaluated radial current that excites the radial electric field. The turbulent Reynolds stress only plays a minor role. The wave convection current that produces a negative current at the edge can be important to explain the ambipolar condition in the L-mode.

  4. E2,M1 multipole mixing ratios in even-even nuclei, 58< or =A< or =150

    International Nuclear Information System (INIS)

    Krane, K.S.

    1977-01-01

    A survey is presented of E2,M1 multipole mixing ratios of gamma-ray transitions in even-even nuclei in the mass range 58< or =A< or =150. Angular distribution and correlation data from the literature are analyzed in terms of a consistent choice of the phase relationship between the E2 and M1 matrix elements. A set of recommended values of the mixing ratios is included based on averages of results from various studies. The survey includes data available in the literature up to December 1976

  5. E2,M1 Multipole mixing ratios in odd-mass nuclei, 59< or =A< or =149

    International Nuclear Information System (INIS)

    Krane, K.S.

    1977-01-01

    A survey is presented of the E2,M1 mxing ratios of gamma-ray transitions in odd-mass nuclei with 59< or =A< or =149. Angular distribution and correlation data from the literature are analyzed in terms of a consistent choice of the phase relationship between the E2 and M1 matrix elements. A set of recommended values of the mixing ratios is included, based on averages of results from various studies. The survey includes data available in the literature up to September 1976

  6. Particle and heat balance analysis in scrape-off and divertor regions of the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Nagashima, K.; Shoji, T.; Tamai, H.; Miura, Y.; Takenaga, H.; Maeda, H.

    1995-01-01

    Particle and heat balance in the scrape-off layer and the divertor region were studied in the JFT-2M tokamak. Using particle and energy conservation laws, particle and heat diffusivities perpendicular to the flux surface were evaluated just outside the magnetic separatrix. It was found that the particle diffusivity decreases with increasing electron density in the scrape-off layer and decreases by a factor of 2-3 in the H-mode phase as compared with that in L-mode. The heat diffusivity has almost the same dependence on the electron density. The ratio of the heat diffusivity to the particle diffusivity is about 2. ((orig.))

  7. Progress in Suppressing Scattered Light into the Optical Beam Path of the NAO Rozhen 2m Telescope

    Science.gov (United States)

    Ovcharov, E. P.; Petrov, N.; Markov, H.; Bonev, T.; Donchev, Z.

    2010-09-01

    In this poster paper we present a summary of the published analysis of the spatial dependence of the magnitudes derived from images obtained in the RC focal plane of the 2m RCC NAO Rozhen telescope. An alert for the possible reason was the unusually curved flat-field images taken as a part of the standard CCD calibration procedure. The reasons for the problem are described and a solution is presented, which consists modification of the mirror baffles and mounting of special diaphragm at the entrance of the filter wheel.

  8. IMP3 RNP safe houses prevent miRNA-directed HMGA2 mRNA decay in cancer and development

    DEFF Research Database (Denmark)

    Jønson, Lars; Christiansen, Jan; Hansen, Thomas van Overeem

    2014-01-01

    by let-7, and let-7 antagomiRs make HMGA2 refractory to IMP3. Removal of let-7 target sites eliminates IMP3-dependent stabilization, and IMP3-containing bodies are depleted of Ago1-4 and miRNAs. The relationship between Hmga2 mRNA and IMPs also exists in the developing limb bud, where IMP1-deficient...... that IMP3 RNPs may function as cytoplasmic safe houses and prevent miRNA-directed mRNA decay of oncogenes during tumor progression....

  9. Radiation induced genetic variability studies in M2 and F2M2 generation in chilli (Capsicum annum L.)

    International Nuclear Information System (INIS)

    Rangaiah, S.; Manjunath, A.; Naik, Puttarama; Gangappa, E.

    2002-01-01

    Chilli (Capsicum annum L.) is an important commercial crop in India. Mutation breeding is one of the effective tool to create new variability. Since, yield and its component characters show polygenic inheritance, information on amount of heritable portion of variability created through mutation for these characters is needed to use the induced variability for crop improvement. To harness more variability mutation has been superimposed on hybridization in several crops. The present study is undertaken to estimate the genetic variability induced through gamma irradiation for the polygenically inherited productive traits of chilli in M 2 and F 2 M 2 generation

  10. Efectos de los suplementos de proteína y aminoácidos de cadena ramificada en entrenamiento de fuerza: revisión bibliográfica

    Directory of Open Access Journals (Sweden)

    Jordi Rabassa-Blanco

    2017-04-01

    Full Text Available Introducción: Los suplementos de proteína y aminoácidos de cadena ramificada (BCAAs son consumidos por la población buscando una serie de efectos fisiológicos y metabólicos sobre el rendimiento y recuperación, entre otros. Objetivos: Revisión de las publicaciones más recientes que estudien los efectos del consumo de suplementos de proteína y BCAAs en entrenamiento de fuerza en diferentes parámetros fisiológicos y metabólicos. Material y métodos: Estudio descriptivo de revisión bibliográfica. Se realizó una búsqueda específica de palabras clave en la base de datos PubMed y estrategia de bola de nieve. Criterios de inclusión: estudios realizados en humanos de ≥ 18 años sin patología, metaanálisis, revisiones sistemáticas y ensayos clínicos controlados aleatorizados en inglés y español relacionados con el consumo de suplementos de proteína y/o BCAAs en entrenamiento de fuerza y sus efectos sobre el daño muscular, respuesta anabólica en la recuperación muscular, ganancia de masa muscular y fuerza, composición corporal y fatiga. Resultados: 64 estudios identificados mediante la ecuación de búsqueda, 20 cumplieron con los criterios de inclusión. La media aritmética de los sujetos participantes fue igual a (30,59 ± 24,47. Conclusiones: Los suplementos de proteína podrían tener un efecto positivo en el aumento del rendimiento y la masa muscular, pero hacen falta más estudios para esclarecer su posible beneficio sobre la composición corporal, la fatiga, la atenuación y reducción del dolor y daño muscular. La leucina tiene efecto en el aumento de la masa muscular y su función en población de edad avanzada. Los BCAAs podrían actuar sobre la atenuación de la fatiga central y en la mejora del rendimiento.

  11. Influencia de la fuerza muscular isométrica de las extremidades superiores en el estrés oxidativo en niños. (Influence of handgrip strength in oxidative stress in children.

    Directory of Open Access Journals (Sweden)

    Manuel Guillén-del Castillo

    2011-01-01

    Full Text Available ResumenEl ejercicio físico puede producir estrés oxidativo en el individuo lo que pueden condicionar el riesgo cardiovascular en niños y adolescentes. Este estudio pretende analizar el estrés oxidativo según la fuerza muscular isométrica de las extremidades superiores en la edad pediátrica. Se estudiaron 70 niños sanos con edades entre 10 y 14 años, y se analizaron en saliva los lipoperóxidos (LPO, el glutatión reducido (GSH, la ratio GSH/LPO y la catalasa, como marcadores de estrés oxidativo. La muestra se dividió en dos grupos según una condición física superior o inferior medida a través de dinamometría manual (TKK 5110; se diferenció la serie en sujetos prepuberales y puberales. Se encontraron niveles significativamente inferiores de GSH y GSH/LPO en el grupo de niños con fuerza superior, y en los puberales con la mismas características; estos resultados podrían indicar la existencia de un mayor estrés oxidativo en esta situación. En conclusión, los mayores niveles de fuerza músculo esquelética, medida a través de dinamometría manual, posiblemente pueden estar asociados a un mayor estrés oxidativo en niños púberes con condición física musculoesquelética superior.AbstractPhysical exercise can produce oxidative stress, this situation could contribute cardiovascular risk in children and adolescents. The following study tries to evaluate the oxidative stress produced according to the handgrip strength in infancy. 70 healthy male subjects, ages 10 to 14 years, were studied. In the saliva samples, lipoperoxides (LPO, reduced glutathione (GSH, glutathione/lipoperoxides ratio and catalase were analyzed as biomarkers of oxidative stress. Children were divided into two groups according to their handgrip strength (high or low measured by handgrip strength (TKK 5110. The groups were also divided into prepubertal and pubertal subjects. We found GSH’s significantly low levels and of GSH/LPO in pubertal group with high

  12. Edge transport barrier modification in the L-2M stellarator depending on the heating power and plasma parameters

    International Nuclear Information System (INIS)

    Voronov, G S; Voronova, E V; Akulina, D K; Gladkov, G A

    2006-01-01

    Boronization of the vacuum chamber of the L-2M stellarator has resulted in modification of the electron temperature profile. In particular, a well-defined jump in the electron temperature to T e ∼ 100 eV in a narrow region Δr/r ∼ 0.05 is observed in the temperature profile at the plasma edge. In the present paper, the value and shape of the jump in T e are studied at different values of plasma parameters and ECR heating power. A jump in T e is absent at a power of P ∼ 100 kW, whereas at P ∼ 200 kW the electron temperature drops from 150 eV to zero within Δr ∼ 0.5 cm. The value of threshold power for the formation of a jump in T e at n e ∼ 1.7 x 10 19 m -3 lies within the range P ∼ 100-160 kW. In terms of power per particle this power threshold is P/V/N e ∼ 0.2-0.3 Mw/m 3 /10 19 m -3 , the value of which coincides with threshold power for ETB formation found recently in the CHS stellarator. When the helical-field strength is 25% or 50% below its standard value, a jump in T e at the plasma edge in L-2M is absent

  13. Effect of the chloride ions on the hydrolysis of praseodymium in a 2M ion force media

    International Nuclear Information System (INIS)

    Lopez G, H.; Jimenez R, M.; Solache R, M.; Rojas H, A.

    2004-01-01

    The constants of the product of solubility and the first of hydrolysis were determined of the Praseodymium in media 2M of NaClO 4 and 2M of NaCl, to 303 K and under conditions free of CO 2 . The diagram of solubility was obtained (pPr (ac) - pC H ), by means of a radiochemical method and with it was established the pC H that limit the saturation and non saturation areas; that diagram allowed, also, to calculate the constant of the product of solubility. Also, it was adjusted with the polynomial of solubility equation, that it allowed to determine and to check the values of the constants of the product of solubility and the first of hydrolysis. Independently, it was determined the first constant of hydrolysis of the element, by means of potentiometric titrations whose data were treated with the computer program named SUPERQUAD and with the adjustment of the equation of the average number of bonds. It was also calculates the log constant β Pr,Cl of the specie PrCI 2+ starting from the hydrolysis constants obtained in the perchlorate and chloride media. (Author)

  14. Oxygen-Glucose Deprivation Induces G2/M Cell Cycle Arrest in Brain Pericytes Associated with ERK Inactivation.

    Science.gov (United States)

    Wei, Wenjie; Yu, Zhiyuan; Xie, Minjie; Wang, Wei; Luo, Xiang

    2017-01-01

    Growing evidence has revealed that brain pericytes are multifunctional and contribute to the pathogenesis of a number of neurological disorders. However, the role of pericytes in cerebral ischemia, and especially the pathophysiological alterations in pericytes, remains unclear. In the present study, our aim was to determine whether the proliferation of pericytes is affected by cerebral ischemia and, if so, to identify the underlying mechanism(s). Cultured brain pericytes subjected to oxygen-glucose deprivation (OGD) were used as our model of cerebral ischemia; the protein expression levels of cyclin D1, cyclin E, cdk4, and cyclin B1 were determined by Western blot analysis, and cell cycle analysis was assessed by flow cytometry. The OGD treatment reduced the brain pericyte proliferation by causing G2/M phase arrest and downregulating the protein levels of cyclin D1, cyclin E, cdk4, and cyclin B1. Further studies demonstrated a simultaneous decrease in the activity of extracellular regulated protein kinases (ERK), suggesting a critical role of the ERK signaling cascade in the inhibition of OGD-induced pericyte proliferation. We suggest that OGD inhibition of the proliferation of brain pericytes is associated with the inactivation of the ERK signaling pathway, which arrests them in the G2/M phase.

  15. Enrofloxacin and Probiotic Lactobacilli Influence PepT1 and LEAP-2 mRNA Expression in Poultry.

    Science.gov (United States)

    Pavlova, Ivelina; Milanova, Aneliya; Danova, Svetla; Fink-Gremmels, Johanna

    2016-12-01

    Expression of peptide transporter 1 (PepT1) and liver-expressed antimicrobial peptide 2 (LEAP-2) in chickens can be influenced by food deprivation, pathological conditions and drug administration. Effect of three putative probiotic Lactobacillus strains and enrofloxacin on the expression of PepT1 and LEAP-2 mRNA was investigated in Ross 308 chickens. One-day-old chicks (n = 24) were allocated to following groups: control (without treatment); group treated with probiotics via feed; group treated with a combination of probiotics and enrofloxacin; and a group given enrofloxacin only. The drug was administered at a dose of 10 mg kg -1 , via drinking water for 5 days. Samples from liver, duodenum and jejunum were collected 126 h after the start of the treatment. Expression levels of PepT1 and LEAP-2 were determined by real-time polymerase chain reaction and were statistically evaluated by Mann-Whitney test. Enrofloxacin administered alone or in combination with probiotics provoked a statistically significant up-regulation of PepT1 mRNA levels in the measured organ sites. These changes can be attributed to a tendency of improvement in utilization of dietary peptide and in body weight gain. LEAP-2 mRNA expression levels did not change significantly in enrofloxacin-treated chickens in comparison with control group.

  16. Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells.

    Science.gov (United States)

    Liu, Kuo-Ching; Shih, Ting-Ying; Kuo, Chao-Lin; Ma, Yi-Shih; Yang, Jiun-Long; Wu, Ping-Ping; Huang, Yi-Ping; Lai, Kuang-Chi; Chung, Jing-Gung

    2016-01-01

    Sulforaphane (SFN), an isothiocyanate, exists exclusively in cruciferous vegetables, and has been shown to possess potent antitumor and chemopreventive activity. However, there is no available information that shows SFN affecting human colon cancer HCT 116 cells. In the present study, we found that SFN induced cell morphological changes, which were photographed by contrast-phase microscopy, and decreased viability. SFN also induced G2/M phase arrest and cell apoptosis in HCT 116 cells, which were measured with flow cytometric assays. Western blotting indicated that SFN increased Cyclin A, cdk 2, Cyclin B and WEE1, but decreased Cdc 25C, cdk1 protein expressions that led to G2/M phase arrest. Apoptotic cell death was also confirmed by Annexin V/PI and DAPI staining and DNA gel electrophoresis in HCT 116 cells after exposure to SFN. The flow cytometric assay also showed that SFN induced the generation of reactive oxygen species (ROS) and Ca[Formula: see text] and decreased mitochondria membrane potential and increased caspase-8, -9 and -3 activities in HCT 116 cell. Western blotting also showed that SFN induced the release of cytochrome c, and AIF, which was confirmed by confocal microscopy examination. SFN induced ER stress-associated protein expression. Based on those observations, we suggest that SFN may be used as a novel anticancer agent for the treatment of human colon cancer in the future.

  17. PKA- and PKC-dependent regulation of angiopoietin 2 mRNA in human granulosa lutein cells.

    Science.gov (United States)

    Witt, P S; Pietrowski, D; Keck, C

    2004-02-01

    New blood vessels develop from preexisting vessels in response to growth factors or hypoxic conditions. Recent studies have shown that angiopoietin 2 (ANGPT-2) plays an important role in the modulation of angiogenesis and vasculogenesis in humans and mice. The signaling pathways that lead to the regulation of ANGPT-2 are largely unclear. Here, we report that protein kinase C and protein kinase A activators (ADMB, 8-Cl-cAMP) increased the mRNA levels of ANGPT-2 in human Granulosa cells, whereas PKC and PKA Inhibitors (Rp-cAMP, GO 6983) decreased markedly the level of ANGPT-2 mRNA. Due to varying specificity of the modulators for certain protein kinases subunits, we conclude that the conventional PKCs, but not PKC alpha and beta1, the atypical PKCs and the PKA I, are involved in the regulation of ANGPT-2. These findings may help to explain the role of both PKA and PKC dependent signaling cascades in the regulation of ANGPT-2 mRNA.

  18. Asperlin induces G{sub 2}/M arrest through ROS generation and ATM pathway in human cervical carcinoma cells

    Energy Technology Data Exchange (ETDEWEB)

    He, Long; Nan, Mei-Hua [Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883 (Korea, Republic of); Oh, Hyun Cheol [College of Medical and Life Sciences, Silla University, 100 Silladaehak-gil, Sasang-gu, Busan 617-736 (Korea, Republic of); Kim, Young Ho [College of Pharmacy, ChungNam National University, Yuseong, Daejeon, 305-764 (Korea, Republic of); Jang, Jae Hyuk [Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883 (Korea, Republic of); Erikson, Raymond Leo [Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138 (United States); Ahn, Jong Seog, E-mail: jsahn@kribb.re.kr [Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883 (Korea, Republic of); Kim, Bo Yeon, E-mail: bykim@kribb.re.kr [Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883 (Korea, Republic of); World Class Institute, KRIBB, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883 (Korea, Republic of)

    2011-06-10

    Highlights: {yields} A new anti-cancer effect of an antibiotics, asperlin, is exploited. {yields} Asperlin induced human cervical cancer cell apoptosis through ROS generation. {yields} Asperlin activated DNA-damage related ATM protein and cell cycle associated proteins. {yields} Asperlin could be developed as a new anti-cancer therapeutics. -- Abstract: We exploited the biological activity of an antibiotic agent asperlin isolated from Aspergillus nidulans against human cervical carcinoma cells. We found that asperlin dramatically increased reactive oxygen species (ROS) generation accompanied by a significant reduction in cell proliferation. Cleavage of caspase-3 and PARP and reduction of Bcl-2 could also be detected after asperlin treatment to the cells. An anti-oxidant N-acetyl-L-cysteine (NAC), however, blocked all the apoptotic effects of asperlin. The involvement of oxidative stress in asperlin induced apoptosis could be supported by the findings that ROS- and DNA damage-associated G2/M phase arrest and ATM phosphorylation were increased by asperlin. In addition, expression and phosphorylation of cell cycle proteins as well as G2/M phase arrest in response to asperlin were significantly blocked by NAC or an ATM inhibitor KU-55933 pretreatment. Collectively, our study proved for the first time that asperlin could be developed as a potential anti-cancer therapeutics through ROS generation in HeLa cells.

  19. Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpoint.

    Directory of Open Access Journals (Sweden)

    Junchao Duan

    Full Text Available Silica nanoparticles have become promising carriers for drug delivery or gene therapy. Endothelial cells could be directly exposed to silica nanoparticles by intravenous administration. However, the underlying toxic effect mechanisms of silica nanoparticles on endothelial cells are still poorly understood. In order to clarify the cytotoxicity of endothelial cells induced by silica nanoparticles and its mechanisms, cellular morphology, cell viability and lactate dehydrogenase (LDH release were observed in human umbilical vein endothelial cells (HUVECs as assessing cytotoxicity, resulted in a dose- and time- dependent manner. Silica nanoparticles-induced reactive oxygen species (ROS generation caused oxidative damage followed by the production of malondialdehyde (MDA as well as the inhibition of superoxide dismutase (SOD and glutathione peroxidase (GSH-Px. Both necrosis and apoptosis were increased significantly after 24 h exposure. The mitochondrial membrane potential (MMP decreased obviously in a dose-dependent manner. The degree of DNA damage including the percentage of tail DNA, tail length and Olive tail moment (OTM were markedly aggravated. Silica nanoparticles also induced G2/M arrest through the upregulation of Chk1 and the downregulation of Cdc25C, cyclin B1/Cdc2. In summary, our data indicated that the toxic effect mechanisms of silica nanoparticles on endothelial cells was through DNA damage response (DDR via Chk1-dependent G2/M checkpoint signaling pathway, suggesting that exposure to silica nanoparticles could be a potential hazards for the development of cardiovascular diseases.

  20. Asperlin induces G2/M arrest through ROS generation and ATM pathway in human cervical carcinoma cells

    International Nuclear Information System (INIS)

    He, Long; Nan, Mei-Hua; Oh, Hyun Cheol; Kim, Young Ho; Jang, Jae Hyuk; Erikson, Raymond Leo; Ahn, Jong Seog; Kim, Bo Yeon

    2011-01-01

    Highlights: → A new anti-cancer effect of an antibiotics, asperlin, is exploited. → Asperlin induced human cervical cancer cell apoptosis through ROS generation. → Asperlin activated DNA-damage related ATM protein and cell cycle associated proteins. → Asperlin could be developed as a new anti-cancer therapeutics. -- Abstract: We exploited the biological activity of an antibiotic agent asperlin isolated from Aspergillus nidulans against human cervical carcinoma cells. We found that asperlin dramatically increased reactive oxygen species (ROS) generation accompanied by a significant reduction in cell proliferation. Cleavage of caspase-3 and PARP and reduction of Bcl-2 could also be detected after asperlin treatment to the cells. An anti-oxidant N-acetyl-L-cysteine (NAC), however, blocked all the apoptotic effects of asperlin. The involvement of oxidative stress in asperlin induced apoptosis could be supported by the findings that ROS- and DNA damage-associated G2/M phase arrest and ATM phosphorylation were increased by asperlin. In addition, expression and phosphorylation of cell cycle proteins as well as G2/M phase arrest in response to asperlin were significantly blocked by NAC or an ATM inhibitor KU-55933 pretreatment. Collectively, our study proved for the first time that asperlin could be developed as a potential anti-cancer therapeutics through ROS generation in HeLa cells.

  1. Study of the G2/M cell cycle checkpoint in irradiated mammary epithelial cells overexpressing Cul-4A gene

    International Nuclear Information System (INIS)

    Gupta, Anu; Yang, L.-X.; Chen, L.-C.

    2002-01-01

    Purpose: Members of the cullin gene family are known to be involved in cell cycle control. One of the cullin genes, Cul-4A, is amplified and overexpressed in breast cancer cells. This study investigates the effect of Cul-4A overexpression upon G2/M cell cycle checkpoint after DNA damage induced by either ionizing or nonionizing radiation. Methods and Materials: The normal mammary epithelial cell line MCF10A was stably transfected with full-length Cul-4A cDNA. Independent clones of MCF10A cells that overexpress Cul-4A proteins were selected and treated with either 8 Gy of ionizing radiation or 7 J/M 2 of UV radiation. The profile of cell cycle progression and the accumulation of several cell cycle proteins were analyzed. Results: We found that overexpression of Cul-4A in MCF10A cells abrogated the G2/M cell cycle checkpoint in response to DNA damage induced by ionizing irradiation, but not to DNA damage induced by nonionizing radiation. Analysis of cell cycle proteins showed that after ionizing irradiation, p53 accumulated in the mock-transfected MCF10A cells, but not in the Cul-4A transfectants. Conclusion: Our results suggest a role for Cul-4A in tumorigenesis and/or tumor progression, possibly through disruption of cell cycle control

  2. La coactivación del bíceps femoral limita la fuerza máxima isométrica de extensión de rodilla en ciclistas de ruta

    OpenAIRE

    García-López, David; Bresciani, Guilherme; Cabeza de Vaca, Salvador; Garatachea, Nuria; De Paz, José

    2006-01-01

    Introducción y objetivos: El objeto del presente estudio fue analizar la coactivación antagonista (bíceps femoral) durante una contracción máxima isométrica de extensión unilateral de rodilla, en ciclistas de ruta, así como su relación con la activación agonista (recto femoral, vasto medial y vasto lateral) y la fuerza manifestada. La activación de los músculos gastrocnemios también fue monitorizada. Métodos: Dieciséis ciclistas federados efectuaron una prueba máxima de extensión isométr...

  3. El papel del razonamiento analógico en la construcción histórica de la noción de fuerza gravitatoria y del modelo de Sistema Solar (I Parte

    Directory of Open Access Journals (Sweden)

    Oliva, J.Mª.

    2004-01-01

    Full Text Available En este artículo, junto a otro que tenemos en preparación, se revisa la importancia del pensamiento analógico en la construcción histórica de la noción de fuerza gravitatoria y del modelo del Sistema Solar. Concretamente, en este primer artículo se empiezan analizando las ideas surgidas al respecto desde las civilizaciones más antiguas, incluida la griega, hasta las aportaciones de figuras como Copérnico, Kepler o el propio Galileo, en los albores de la revolución copernicana. En el otro, pendiente de publicar en un próximo número, se discuten algunos de los razonamientos analógicos formulados con posterioridad a partir de la segunda mitad del siglo XVII y que culminaría con la síntesis newtoniana.

  4. Evaluación técnica informática de los procesos de gobierno de TI (Evaluar, Orientar y Supervisar) al sistema de información de la Universidad de las Fuerzas Armadas "ESPE". Sede Principal

    OpenAIRE

    Guanotuña Lascano, Emily Jeanette; Chávez Ñauñay, Carlos Patricio

    2016-01-01

    La Evaluación Técnica Informática de los Procesos de Gobierno de TI al Sistema de Información de la Universidad de las Fuerzas Armadas ESPE Matriz, utiliza el marco de referencia COBIT 5 e identifica los procesos más críticos de la Institución a través de una matriz de riesgo elaborada de acuerdo a los criterios establecidos en este marco de referencia. Se elabora un programa detallado de Auditoría, mediante una matriz de investigación de campo, en la que se detalla el objeto del análisis, lo...

  5. La imposibilidad de un ejército profesional: Ramón de Cáceres y el establecimiento de procedimientos burocráticos en las fuerzas del Río de la Plata. 1810-1830

    Directory of Open Access Journals (Sweden)

    Alejandro M. Rabinovich

    2013-01-01

    Full Text Available El presente artículo aborda la problemática de la profesionalización de las fuerzas militares del Estado rioplatense independiente a partir de un ángulo muy poco analizado hasta hoy: los intentos de establecer procedimientos burocráticos y un tipo particular de disciplina en el seno de unidades combatientes surgidas de una intensa movilización popular.Primero se analizarán las reglamentaciones que regían la administración de los ejércitos, con especial énfasis en la descripción del tipo de funcionariado que era buscado por los modelos europeos de la época. Luego, este deber serde la administración militar será confrontado con el estudio de un caso puntual: el traumático intento de transformación de los Dragones Libertadores surgidos del alzamiento de la campaña oriental en 1825 en Regimiento de Caballería de Línea, ocurrido en el seno del Ejército Republicano que se aprestaba para abrir la guerra con el Brasil. Este modesto episodio, explorado a través de las memorias personales del oficial a cargo de llevar adelante la reforma del cuerpo, nos permitirá echar luz sobre las limitaciones concretas encontradas en el terreno por aquellos funcionarios que hablaban en nombre del Estado y pretendían someter a las fuerzas de un pueblo en armas a una lógica procedimental- formal.

  6. Valoración de la influencia de la práctica del fútbol en la evolución de la fuerza, la flexibilidad y la velocidad en población infantil

    Directory of Open Access Journals (Sweden)

    Silvia Sedano Campo*

    2007-03-01

    Full Text Available El objetivo del estudio es valorar la influencia que la práctica regular del fútbol tiene sobre algunos aspectos de la condición física (fuerza explosiva del tren inferior, flexibilidad y velocidad en niños de entre 7 y 14 años. Por otro lado también pretendemos determinar la correlación existente entre las tres capacidades evaluadas, comparar los resultados con población infantil general y analizar las posibles influencias que la práctica de este deporte puede tener en el desarrollo evolutivo. La muestra se compone de 106 niños que practican fútbol federado en clubes de la comunidad de Castilla y León. En primer lugar determinamos el peso y la talla de cada participante en el estudio y posteriormente pasamos tres pruebas de valoración de la condición física que forman parte de la batería EUROFIT: Flexión de tronco desde posición de sentados, salto horizontal y carrera de 10 X 5 m ida y vuelta. Se observa la importante influencia que la práctica del fútbol tiene en la flexibilidad y la velocidad cuando comparamos los datos con los obtenidos en escolares de la misma comunidad autónoma. Se observa también la correlación fuerte y positiva existente entre la fuerza y la velocidad

  7. Reactions of Cp2MCl2 (M=Ti or Zr with Imine-Oxime Ligands. Formation of Metallacycles

    Directory of Open Access Journals (Sweden)

    C. Tripathi

    2005-07-01

    Full Text Available The reactions of bis(cyclopentadienyltitanium(IV/zirconium(IV dichloridewith a series of imine-oxime ligands (LH2, derived by condensing benzil-α-monoxime and2-phenylenediamine, 4-phenylenediamine, 4-methyl-2-phenylenediamine, 2,6-diamino-pyridine, have been studied in anhydrous tetrahydrofuran in the presence of base andmetallocycles of the [Cp2M(L] (M=Ti or Zr type have been isolated. Tentative structureshave been proposed for the products based on elemental analysis, electrical conductance andspectral (electronic, IR and 1H-NMR data. Proton NMR spectra indicate that on the NMRtime scale there is rapid rotation of the cyclopentadienyl ring around the metal-ring axis at25oC. Studies were conducted to assess the growth inhibiting potential of the complexessynthesized and the ligands against various bacterial strains.

  8. Optimization and calculation of the MCl-ZnCl{sub 2} (M = Li, Na, K) phase diagrams

    Energy Technology Data Exchange (ETDEWEB)

    Romero-Serrano, Antonio, E-mail: romeroipn@hotmail.com [Metallurgy and Materials Department, Instituto Politecnico Nacional-ESIQIE, Apdo. P. 118-431, 07051 Mexico, D.F. (Mexico); Hernandez-Ramirez, Aurelio, E-mail: aurelioh@hotmail.com [Metallurgy and Materials Department, Instituto Politecnico Nacional-ESIQIE, Apdo. P. 118-431, 07051 Mexico, D.F. (Mexico); Cruz-Ramirez, Alejandro, E-mail: alcruzr@ipn.mx [Metallurgy and Materials Department, Instituto Politecnico Nacional-ESIQIE, Apdo. P. 118-431, 07051 Mexico, D.F. (Mexico); Hallen-Lopez, Manuel, E-mail: j_hallen@yahoo.com [Metallurgy and Materials Department, Instituto Politecnico Nacional-ESIQIE, Apdo. P. 118-431, 07051 Mexico, D.F. (Mexico); Zeifert, Beatriz, E-mail: bzeifert@yahoo.com [Metallurgy and Materials Department, Instituto Politecnico Nacional-ESIQIE, Apdo. P. 118-431, 07051 Mexico, D.F. (Mexico)

    2010-10-20

    An earlier structural model for binary silicate melts and glasses is extended to zinc chloride-alkali metal chloride systems. The evaluation of the available thermodynamic and phase diagrams data for the MCl-ZnCl{sub 2} (M = Li, Na, K) binary systems have been carried out using the structural model for the liquid phase. This thermodynamic model is based on the assumption that each alkali chloride produces the depolymerization of ZnCl{sub 2} network with a characteristic free-energy change. A least-squares optimization program permits all available thermodynamic and phase diagram data to be optimized simultaneously. In this manner, data for these binary systems have been analysed and represented with a small number of parameters.

  9. Measurement of anisotropic soft X-ray emission during radio-frequency current drive in the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Kawashima, Hisato; Matoba, Tohru; Hoshino, Katsumichi; Kawakami, Tomohide; Yamamoto, Takumi; Hasegawa, Mitsuru; Fuchs, Gerhard; Uesugi, Yoshihiko.

    1994-01-01

    A new vertical soft X-ray pulse height analyzer (PHA) system and a tangential PHA system were used to measure the anisotropy of soft X-ray emission during lower-hybrid current drive (LHCD) and also during current drive by the combination of LHCD and electron cyclotron resonance heating (ECRH) in the JFT-2M tokamak. The strong soft X-ray emission was measured in the parallel forward direction during LHCD. When ECRH was applied during LHCD, the perpendicular emission was enhanced. The high-energy electron velocity distribution was evaluated by comparing the measured and calculated X-ray spectra. The distribution form was consistent with the theoretical prediction based on the electron Landau damping of lower-hybrid waves and the electron cyclotron damping of electron cyclotron waves for reasonable energy ranges. (author)

  10. Effective Lagrangians, Watson's theorem and the E2/M1 mixing ratio in the excitation of the Delta resonance

    International Nuclear Information System (INIS)

    Davidson, R.M.

    1992-01-01

    The author investigates theoretical uncertainties and model dependence in the extraction of the nucleon-delta(1232) electromagnetic transition amplitudes from the multipole data base. The starting point is an effective Lagrangian incorporating chiral symmetry, which includes at the tree level the pseudovector Born terms, leading t-channel vector meson exchanges, and s and u channel delta exchanges. The nucleon-delta magnetic dipole (M1) and electric quadrupole (E2) transition amplitudes are expressed in terms of two independent gauge couplings at the γNΔ vertex. After unitarizing the tree level amplitude, the gauge couplings are fitted to various multipole data sets, thus determining E2 and M1. Although there is much sensitivity to the method used to unitarize the amplitude, the author extracts the E2/M1 ratio to be negative, with a magnitude around 1.5%. 11 refs., 3 figs

  11. Self-similarity of fluctuation particle fluxes in the plasma edge of the stellarator L-2M

    Energy Technology Data Exchange (ETDEWEB)

    Saenko, V.V. [Ulyanovsk State University, Leo Tolstoy str., 42, Ulyanovsk (Russian Federation)

    2010-05-15

    Results are presented of statistical studies of probability density of fluctuations of plasma density, floating potential, and turbulent particle fluxes measured by a Langmuir probe in the edge plasma of the L-2M stellarator. Empirical probability densities differ from Gaussian distributions. The empirical probability density distributions have heavy tails decreasing as x{sup -{alpha}}{sup -1} and are leptokurtic. Fractional stable distributions were successfully applied to describing such distributions. It is shown that fractional stable distributions give good fit to the distri-butions of increments of fluctuation amplitudes of physical variables under study. The distribution parameters are statistically estimated from measured time sequences (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  12. Self-similarity of fluctuation particle fluxes in the plasma edge of the stellarator L-2M

    International Nuclear Information System (INIS)

    Saenko, V.V.

    2010-01-01

    Results are presented of statistical studies of probability density of fluctuations of plasma density, floating potential, and turbulent particle fluxes measured by a Langmuir probe in the edge plasma of the L-2M stellarator. Empirical probability densities differ from Gaussian distributions. The empirical probability density distributions have heavy tails decreasing as x -α-1 and are leptokurtic. Fractional stable distributions were successfully applied to describing such distributions. It is shown that fractional stable distributions give good fit to the distri-butions of increments of fluctuation amplitudes of physical variables under study. The distribution parameters are statistically estimated from measured time sequences (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  13. Numerical study of the electron heating and current drive by the fast waves in the JFT-2M tokamak plasma

    International Nuclear Information System (INIS)

    Yamamoto, Takumi; Uesugi, Yoshihiko; Hoshino, Katsumichi; Kawashima, Hisato; Ohtsuka, Hideo

    1986-08-01

    A 200 MHz fast wave experiment for the JET-2M tokamak is examined. Noticeable single-path electron Landau damping of the fast waves with the parallel refractive index of N // = 4 is expected in the plasma with electron temperature more than 2.5 keV at the electron density of n e = 1.5 x 10 19 m -3 . Furthermore, it is shown that 8 kA of the plasma current is driven by the fast waves with N //≅ 2 at n e = 3 x 10 19 m -3 in the single-path damping when 100 kW of the rf power radiates into the plasma in the presence of the hot electrons with the temperature of 19 keV and the fraction of the density of 2 %. (author)

  14. Superconducting snake with the field of 75 kGs for the VEPP-2M electron-positron storage ring

    International Nuclear Information System (INIS)

    Anashin, V.V.; Vasserman, I.B.; Vlasov, A.M.

    1985-01-01

    Superconducting ''snake'' with the field of 75 kG is established in the VEPP-2M electron-positron storage ring for increase of colliding beam luminosity up to 2x10 31 cmsup(-2)sdup(-1) in the energy range from 2x200 to 2x700 MeV. The ''snake'' comprises three central magnets with the field of 75 kG and two side ones with the field of 45 kG and it is placed in one of rectilinear experimental gaps. Description of design peculiarities of the ''snake'' and its parameters are given. Parameters of beams with switched on and switched off ''snake'' as well as parameters of coils and superconducting wire are presented

  15. Rapid change of ion energy distribution and floating potential at L/H transition in the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Miura, Y.; Nagashima, K.; Okano, F.

    1994-01-01

    Rapid changes of the main ion energy distribution at transitions from L-to-H, H-to-L and during ELMs are studied with the time of flight neutral measurement in the JFT-2M tokamak. The change of the main ion energy distribution after sawtooth crash during an L-mode phase is also studied. The change of the ion energy distribution just after sawtooth crash is the same as that at L/H-transition. The floating potential measured in the SOL also shows the rapid jump to more positive just after the sawtooth crash (at the same time of the change of an ion energy distribution). This shows the increase of ion outflux in the SOL and might correspond to the change of the ion energy distribution. This may be the reason why most of H-modes are triggered by a sawtooth. (author)

  16. Development of ion diagnostic system based on electrostatic probe in the boundary plasma of the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Uehara, Kazuya; Kawakami, Tomohide; Amemiya, Hiroshi; Hoethker, K.; Cosler, A.; Bieger, W.

    1995-06-01

    An ion diagnostic system using electrostatic probes for measurements in the JFT-2M tokamak boundary plasma has been developed under the collaboration program between KFA and JAERI. The rotating double probe system, on which the Hoethker double probe and Amemiya asymmetric probe can mounted, are manufactured at KFA workshop while the linear driver to support the rotating double probe, the ion toothbrush probe, the Katsumata probe and the cubic Mach probe are developed at JAERI. This report describes the hardware of this probe system for ion diagnostics in the boundary plasma and preliminary data obtained by means of this system. Furthermore, results on the transport are estimated on the basis of these probe data. (author)

  17. FOXC2 mRNA Expression and a 5' untranslated region polymorphism of the gene are associated with insulin resistance

    DEFF Research Database (Denmark)

    Ridderstråle, Martin; Carlsson, Emma; Klannemark, Mia

    2002-01-01

    with subcutaneous fat from obese subjects (12 +/- 4-fold; P = 0.0001), and there was a correlation between whole-body insulin sensitivity and FOXC2 mRNA levels in visceral fat (fS-insulin R = -0.64, P = 0.01, and homeostasis model assessment of insulin resistance [HOMA-IR] R = -0.68, P = 0.007) and skeletal muscle...... (fS-insulin R = -0.57, P = 0.03, and HOMA-IR R = -0.55, P = 0.04). Mutation screening of the FOXC2 gene identified a common polymorphism in the 5' untranslated region (C-512T). The T allele was associated with enhanced insulin sensitivity (HOMA-IR P = 0.007) and lower plasma triglyceride levels...

  18. Vibrational frequencies and structural investigation of (M(CN)4)2- (M Cd, Hg and Zn) ions

    International Nuclear Information System (INIS)

    Gurkan, Keshan; Tomas, Polivka; Cemal, Parlak; Mustafa, Shenyel

    2011-01-01

    The normal mode frequencies and corresponding vibrational assignments of tetracyanometallate (II) ions ([M(CN) 4 ] 2 -, M = Cd, Hg and Zn) have been theoretically examined by means of standard quantum chemical techniques. All normalmodes have been successfully assigned to one of six types of motion utilizing the T d symmetry of M(CN) 4 2 -. Calculations have been performed at the Becke-3-Lee-Yang-Parr (B3LYP) density functional method using the Lanl2dz effective core basis set. Furthermore, reliable vibrational assignments have been made on the basis of potential energy distribution (PED) calculated and the thermodynamics functions, highest occupied and lowest unoccupied molecular orbitals (HOMO and LUMO) of the title ions have been predicted together with their infrared intensities and Raman activities. Theoretical results have been successfully compared against available experimental data

  19. Bispectral analysis applied to coherent floating potential fluctuations obtained in the edge plasmas on JFT-2M

    International Nuclear Information System (INIS)

    Nagashima, Y; Itoh, K; Itoh, S-I; Fujisawa, A; Hoshino, K; Takase, Y; Yagi, M; Ejiri, A; Ida, K; Shinohara, K; Uehara, K; Kusama, Y

    2006-01-01

    This paper presents results of bispectral analysis applied to floating potential fluctuations in the edge region of ohmically heated plasmas in the JAERI Fusion Torus-2 Modified (JFT-2M) tokamak. Inside the outermost surface of plasmas, coherent mode fluctuations (CMs) in floating potential were observed around the frequency of the geodesic acoustic mode. The squared bicoherence shows significant nonlinear couplings between the CMs and background fluctuations. The biphase at the frequency of the CMs is localized around π, while that at frequencies of background fluctuations distributes in a wide range. The total bicoherence at the frequency of the CMs is proportional to the squared amplitude of the CMs. These observations are consistent with the theoretical prediction on the drift wave-zonal flow systems. Interpretation of the absolute value of the total bicoherence is also discussed

  20. Glycosaminoglycans enhance the fibrillation propensity of the ß2-microglobulin cleavage variant--¿K58-ß2m

    DEFF Research Database (Denmark)

    Corlin, Dorthe B; Johnsen, Christina K; Nissen, Mogens H

    2010-01-01

    when heparan sulfate is present have increased length and diameter, and possess enhanced stability and seeding properties. However, when copper ions are present the fibrils are short, thin and less stable, and form at a slower rate. We suggest that heparan sulfate stabilizes the cleaved monomers...... in the early aggregates, hereby promoting the assembly of these into fibrils, whereas the copper ions appear to have a destabilizing effect on the monomers. This keeps them in a structure forming amorphous aggregates for a longer period of time, leading to the formation of spherical bodies followed...... by the assembly of fibrils. Hence, the in vivo formation of amyloid fibrils in DRA could be initiated by the generation of ¿K58-ß2m which spontaneously aggregate and form fibrils. The fibrillogenesis is enhanced by the involvement of GAGs and/or metal ions, and results in amyloid-like fibrils able to promote...

  1. Testing of the method for water microleakage detection from OH hydroxyl spectral lines at the L-2M stellarator

    International Nuclear Information System (INIS)

    Voronov, G. S.; Berezhetskii, M. S.; Bondar’, Yu. F.; Vafin, I. Yu.; Vasil’kov, D. G.; Voronova, E. V.; Grebenshchikov, S. E.; Grishina, I. A.; Larionova, N. F.; Letunov, A. A.; Logvinenko, V. P.; Meshcheryakov, A. I.; Pleshkov, E. I.; Khol’nov, Yu. V.; Fedyanin, O. I.; Tsygankov, V. A.; Shchepetov, S. V.; Kurnaev, V. A.; Vizgalov, I. V.; Urusov, V. A.

    2013-01-01

    Results are presented from L-2M stellarator experiments on testing a possible method for detection of water microleakages in the cooling system of the first wall and vacuum chamber of ITER. The method consists in the spectroscopic detection of spectral lines of the OH hydroxyl, which forms via the dissociation of water molecules in plasma. Emission in the spectral band of 305–310 nm can be detected even at water leakage rates less than 10 −4 Pa m 3 /s. Chemical reactions between water and boron compounds on the vacuum chamber wall delay the detection of leakages up to ∼2000 s. A similar phenomenon can be expected when a leakage will occur in ITER, where the materials suggested for the first wall (Be, Li) can also chemically react with water.

  2. The Liverpool Telescope: rapid follow-up observation of targets of opportunity with a 2 m robotic telescope

    International Nuclear Information System (INIS)

    Gomboc, Andreja; Bode, Michael F.; Carter, David; Mundell, Carol G.; Newsam, Andrew; Smith, Robert J.; Steele, Iain A.

    2004-01-01

    The Liverpool Telescope, situated at Roque de los Muchachos Observatory, La Palma, Canaries, is the first 2-m, fully instrumented robotic telescope. It recently began observations. Among Liverpool Telescope's primary scientific goals is to monitor variable objects on all timescales from seconds to years. An additional benefit of its robotic operation is rapid reaction to unpredictable phenomena and their systematic follow up, simultaneous or coordinated with other facilities. The Target of Opportunity Programme of the Liverpool Telescope includes the prompt search for and observation of GRB and XRF counterparts. A special over-ride mode implemented for GRB/XRF follow-up enables observations commencing less than a minute after the alert, including optical and near infrared imaging and spectroscopy. In particular, the moderate aperture and rapid automated response make the Liverpool Telescope excellently suited to help solving the mystery of optically dark GRBs and for the investigation of currently unstudied short bursts and XRFs

  3. IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes

    DEFF Research Database (Denmark)

    Christiansen, J.; Kolte, A.M.; Hansen, T.O.

    2009-01-01

    Recent genome-wide association (GWA) studies of type 2 diabetes (T2D) have implicated IGF2 mRNA-binding protein 2 (IMP2/IGF2BP2) as one of the several factors in the etiology of late onset diabetes. IMP2 belongs to a family of oncofetal mRNA-binding proteins implicated in RNA localization...... and T2D Udgivelsesdato: 2009/11......, stability, and translation that are essential for normal embryonic growth and development. This review provides a background to the IMP protein family with an emphasis on human IMP2, followed by a closer look at the GWA studies to evaluate the significance, if any, of the proposed correlation between IMP2...

  4. Measurement of cold neutron spectra at a model of cryogenic moderator of the IBR-2M reactor

    International Nuclear Information System (INIS)

    Kulikov, S.A.; Chernikov, A.N.; Shabalin, E.P.; Kalinin, I.V.; Morozov, V.M.; Novikov, A.G.; Puchkov, A.V.

    2010-01-01

    The article is dedicated to methods and results of experimental determination of cold neutron spectra from solid mesitylene at neutron moderator temperatures 10-50 K. Experiments were fulfilled at the DIN-2PI spectrometer of the IBR-2 reactor. The main goals of this work were to examine a system of constants for Monte Carlo calculation of cryogenic moderators of the IBR-2M reactor and to determine the temperature dependence of cold neutron intensity from the moderator. A reasonable agreement of experimental and calculation results for mesitylene at 20 K has been obtained. The cold neutron intensity at temperature of moderator 10 K is about 1.8 times higher than at T=50 K

  5. PERANCANGAN MODEL AIR ALIRAN SILANG (CROSS FLOW TURBINE DENGAN HEAD 2 m DAN DEBIT 0,03 m3/s

    Directory of Open Access Journals (Sweden)

    Ridwan Ridwan

    2017-01-01

    Full Text Available Pembangkit listrik tenaga mikrohidro merupakan pembangkit listrik skala kecil yang menggunakan air sebagai penggeraknya dan penggerak mula adalah turbin. Sistem pembangkit ini sangat tepat digunakan di pedesaan karena sistem ini mudah dibuat, menghasilkan daya listrik yang cukup besar dan biaya pembuatan yang lebih relatif murah. Atas dasar diatas maka perlu dirancang suatu turbin yang mendukung sistem pembangkit ini, diantaranya adalah Turbin Aliran Silang. Untuk merancang sebuah turbin air agar tidak terjadi kesalahan dalam perancangan (seperti hal-nya biaya pembuatannya maka dilakukan perancangan prototipenya. Sebuah prototipe Turbin Aliran Silang dirancang dalam kegiatan tugas akhir ini dengan debit (Q = 0,03  m3/s, head (H = 2 m dengan efisiensi 0,80. Spesifikasi teknik utama dari hasil perancangan turbin adalah diameter runner (D = 0,195 m dengan putaran turbin 281,39 rpm daya keluaran efektif sebesar 470,4 W.

  6. Measurement of peripheral electron temperature by electron cyclotron emission during the H-mode transition in JFT-2M tokamak

    International Nuclear Information System (INIS)

    Hoshino, Katsumichi; Yamamoto, Takumi; Kawashima, Hisato

    1987-01-01

    Time evolution and profile of peripheral electron temperature during the H-mode like transition in a tokamak plasma is measured using the second and third harmonic of electron cyclotron emission (ECE). The so called ''H-mode'' state which has good particle/energy confinement is characterized by sudden decrease in the spectral line intensity of deuterium molecule. Such a sudden decrease in the line intensity of D α with good energy confinement is found not only in divertor discharges, but also in limiter dischargs in JFT-2M tokamak. It is found by the measurement of ECE that the peripheral electron temperature suddenly increases in both of such phases. The relation between H-transition and the peripheral electron temperature or its profile is investigated. (author)

  7. X-ray spectra, chemical bonding, and electron structure of ScM2Si2 (M = Fe, Co, Ni)

    International Nuclear Information System (INIS)

    Shcherba, I.D.; Kotur, B.Ya.

    1990-01-01

    In a study of the interaction of the components in the ternary systems Sc-M-Si (where M is a 3d transition metal) it was established that there are compounds of the empirical formula ScM 2 Si 2 (M = Fe, Co, Ni). They crystallize in two structural types, HfFe 2 Si 2 (the compound ScFe 2 Si 2 ) and CeGa 2 Al 2 (ScCo 2 Si 2 and ScNi 2 Si 2 ) (ref. 1), leading to different coordination environment of the atoms in the structures of the compounds. With the aim of investigating the electron structure and the type ofin these compounds, they authors made a systematic x-ray spectral investigation with simultaneous analysis of the crystal structures of ScM 2 Si 2

  8. The 20-hydroxyecdysone-induced signalling pathway in G2/M arrest of Plodia interpunctella imaginal wing cells.

    Science.gov (United States)

    Siaussat, David; Bozzolan, Françoise; Porcheron, Patrick; Debernard, Stéphane

    2008-05-01

    The mechanisms involved in the control of cellular proliferation by the steroid hormone 20-hydroxyecdysone (20E) in insects are not known. We dissected the 20E signalling pathway responsible for G2/M arrest of imaginal cells from the IAL-PID2 cells of the Indian meal moth Plodia interpunctella. We first used a 5'-3' RACE-based strategy to clone a 4479bp cDNA encoding a putative P. interpunctella HR3 transcription factor named PiHR3. The deduced amino acid sequence of PiHR3 was highly similar to those of HR3 proteins from other lepidopterans, e.g. Manduca sexta and Bombyx mori. Using double-stranded RNA-mediated interference (dsRNAi), we then succeeded in blocking the ability of 20E to induce the expression of PiEcR-B1, PiUSP-2 and PiHR3 genes that encode the P. interpunctella ecdysone receptor B1-isoform, Ultraspiracle-2 isoform, the insect homologue of the vertebrate retinoid X receptor, and the HR3 transcription factor. We showed that inhibiting the 20E induction of PiEcR-B1, PiUSP-2 and PiHR3 mRNAs prevented the decreased expression of B cyclin and consequently the G2/M arrest of IAL-PID2 cells. Using this functional approach, we revealed the participation of EcR, USP and HR3 in a 20E signalling pathway that controls the proliferation of imaginal cells by regulating the expression of B cyclin.

  9. Staphylococcus aureus-induced G2/M phase transition delay in host epithelial cells increases bacterial infective efficiency.

    Directory of Open Access Journals (Sweden)

    Ludmila Alekseeva

    Full Text Available Staphylococcus aureus is a highly versatile, opportunistic pathogen and the etiological agent of a wide range of infections in humans and warm-blooded animals. The epithelial surface is its principal site of colonization and infection. In this work, we investigated the cytopathic effect of S. aureus strains from human and animal origins and their ability to affect the host cell cycle in human HeLa and bovine MAC-T epithelial cell lines. S. aureus invasion slowed down cell proliferation and induced a cytopathic effect, resulting in the enlargement of host cells. A dramatic decrease in the number of mitotic cells was observed in the infected cultures. Flow cytometry analysis revealed an S. aureus-induced delay in the G2/M phase transition in synchronous HeLa cells. This delay required the presence of live S. aureus since the addition of the heat-killed bacteria did not alter the cell cycle. The results of Western blot experiments showed that the G2/M transition delay was associated with the accumulation of inactive cyclin-dependent kinase Cdk1, a key inducer of mitosis entry, and with the accumulation of unphosphorylated histone H3, which was correlated with a reduction of the mitotic cell number. Analysis of S. aureus proliferation in asynchronous, G1- and G2-phase-enriched HeLa cells showed that the G2 phase was preferential for bacterial infective efficiency, suggesting that the G2 phase delay may be used by S. aureus for propagation within the host. Taken together, our results divulge the potential of S. aureus in the subversion of key cellular processes such as cell cycle progression, and shed light on the biological significance of S. aureus-induced host cell cycle alteration.

  10. Information and Communications Technology (ICT) Infrastructure for the ASTRI SST-2M telescope prototype for the Cherenkov Telescope Array

    Science.gov (United States)

    Gianotti, F.; Tacchini, A.; Leto, G.; Martinetti, E.; Bruno, P.; Bellassai, G.; Conforti, V.; Gallozzi, S.; Mastropietro, M.; Tanci, C.; Malaguti, G.; Trifoglio, M.

    2016-08-01

    The Cherenkov Telescope Array (CTA) represents the next generation of ground-based observatories for very high energy gamma-ray astronomy. The CTA will consist of two arrays at two different sites, one in the northern and one in the southern hemisphere. The current CTA design foresees, in the southern site, the installation of many tens of imaging atmospheric Cherenkov telescopes of three different classes, namely large, medium and small, so defined in relation to their mirror area; the northern hemisphere array would consist of few tens of the two larger telescope types. The Italian National Institute for Astrophysics (INAF) is developing the Cherenkov Small Size Telescope ASTRI SST- 2M end-to-end prototype telescope within the framework of the International Cherenkov Telescope Array (CTA) project. The ASTRI prototype has been installed at the INAF observing station located in Serra La Nave on Mt. Etna, Italy. Furthermore a mini-array, composed of nine of ASTRI telescopes, has been proposed to be installed at the Southern CTA site. Among the several different infrastructures belonging the ASTRI project, the Information and Communication Technology (ICT) equipment is dedicated to operations of computing and data storage, as well as the control of the entire telescope, and it is designed to achieve the maximum efficiency for all performance requirements. Thus a complete and stand-alone computer centre has been designed and implemented. The goal is to obtain optimal ICT equipment, with an adequate level of redundancy, that might be scaled up for the ASTRI mini-array, taking into account the necessary control, monitor and alarm system requirements. In this contribution we present the ICT equipment currently installed at the Serra La Nave observing station where the ASTRI SST-2M prototype will be operated. The computer centre and the control room are described with particular emphasis on the Local Area Network scheme, the computing and data storage system, and the

  11. Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R.

    Science.gov (United States)

    Li, Ge; Park, Hyeon U; Liang, Dong; Zhao, Richard Y

    2010-07-07

    Cell cycle G2 arrest induced by HIV-1 Vpr is thought to benefit viral proliferation by providing an optimized cellular environment for viral replication and by skipping host immune responses. Even though Vpr-induced G2 arrest has been studied extensively, how Vpr triggers G2 arrest remains elusive. To examine this initiation event, we measured the Vpr effect over a single cell cycle. We found that even though Vpr stops the cell cycle at the G2/M phase, but the initiation event actually occurs in the S phase of the cell cycle. Specifically, Vpr triggers activation of Chk1 through Ser345 phosphorylation in an S phase-dependent manner. The S phase-dependent requirement of Chk1-Ser345 phosphorylation by Vpr was confirmed by siRNA gene silencing and site-directed mutagenesis. Moreover, downregulation of DNA replication licensing factors Cdt1 by siRNA significantly reduced Vpr-induced Chk1-Ser345 phosphorylation and G2 arrest. Even though hydroxyurea (HU) and ultraviolet light (UV) also induce Chk1-Ser345 phosphorylation in S phase under the same conditions, neither HU nor UV-treated cells were able to pass through S phase, whereas vpr-expressing cells completed S phase and stopped at the G2/M boundary. Furthermore, unlike HU/UV, Vpr promotes Chk1- and proteasome-mediated protein degradations of Cdc25B/C for G2 induction; in contrast, Vpr had little or no effect on Cdc25A protein degradation normally mediated by HU/UV. These data suggest that Vpr induces cell cycle G2 arrest through a unique molecular mechanism that regulates host cell cycle regulation in an S-phase dependent fashion.

  12. Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R

    Directory of Open Access Journals (Sweden)

    Liang Dong

    2010-07-01

    Full Text Available Abstract Background Cell cycle G2 arrest induced by HIV-1 Vpr is thought to benefit viral proliferation by providing an optimized cellular environment for viral replication and by skipping host immune responses. Even though Vpr-induced G2 arrest has been studied extensively, how Vpr triggers G2 arrest remains elusive. Results To examine this initiation event, we measured the Vpr effect over a single cell cycle. We found that even though Vpr stops the cell cycle at the G2/M phase, but the initiation event actually occurs in the S phase of the cell cycle. Specifically, Vpr triggers activation of Chk1 through Ser345 phosphorylation in an S phase-dependent manner. The S phase-dependent requirement of Chk1-Ser345 phosphorylation by Vpr was confirmed by siRNA gene silencing and site-directed mutagenesis. Moreover, downregulation of DNA replication licensing factors Cdt1 by siRNA significantly reduced Vpr-induced Chk1-Ser345 phosphorylation and G2 arrest. Even though hydroxyurea (HU and ultraviolet light (UV also induce Chk1-Ser345 phosphorylation in S phase under the same conditions, neither HU nor UV-treated cells were able to pass through S phase, whereas vpr-expressing cells completed S phase and stopped at the G2/M boundary. Furthermore, unlike HU/UV, Vpr promotes Chk1- and proteasome-mediated protein degradations of Cdc25B/C for G2 induction; in contrast, Vpr had little or no effect on Cdc25A protein degradation normally mediated by HU/UV. Conclusions These data suggest that Vpr induces cell cycle G2 arrest through a unique molecular mechanism that regulates host cell cycle regulation in an S-phase dependent fashion.

  13. [Pseudolaric acid B induces G2/M arrest and inhibits invasion and migration in HepG2 hepatoma cells].

    Science.gov (United States)

    Li, Shuai; Guo, Lianyi

    2018-01-01

    Objective To investigate the mechanisms of pseudolaric acid B (PAB) blocks cell cycle and inhibits invasion and migration in human hepatoma HepG2 cells. Methods The proliferation effect of PAB on HepG2 cells was evaluated by MTT assay. The effect of PAB on the cell cycle of HepG2 cells was analyzed by flow cytometry. Immunofluorescence cytochemical staining was applied to observe the effect of PAB on the α-tubulin polymerization and expression in HepG2 cells. Transwell TM chamber invasion assay and wound healing assay were performed to detect the influence of PAB on the migration and invasion ability of HepG2 cells. Western blotting was used to determine the expressions of α-tubulin, E-cadherin and MMP-9 in HepG2 cells after treated with PAB. Results PAB inhibited the proliferation of HepG2 cells in a dose-dependent manner and blocked the cell cycle in G2/M phase. PAB significantly changed the polymerization and decreased the expression of α-tubulin. The capacities of invasion and migration of HepG2 cells treated by PAB were significantly depressed. The protein levels of α-tubulin and MMP-9 decreased while the E-cadherin protein level increased. Conclusion PAB can inhibits the proliferation of HepG2 cells by down-regulating the expression of α-tubulin and influencing its polymerization, arresting HepG2 cells in G2/M phase. Meanwhile, PAB also can inhibit the invasion and migration of HepG2 cells by lowering cytoskeleton α-tubulin and MMP-9, and increasing E-cadherin.

  14. Phorbol esters induce interleukin 2 mRNA in sensitive but not in resistant EL4 cells

    International Nuclear Information System (INIS)

    Harrison, J.R.; Lynch, K.R.; Sando, J.J.

    1986-01-01

    Phorbol ester (PE) sensitive EL4 cells are growth-inhibited and produce interleukin 2 (IL2) when treated with PE. Resistant EL4 cells lack both responses. To determine whether the defect in resistant cells occurs pre or post-transcriptionally, an assay for IL2 mRNA was developed using a synthetic oligonucleotide to mouse IL2 as a probe. Total RNA (15 μg) from cells +/- PE was electrophoresed, blotted onto a cationic nylon membrane, and probed with radiolabeled oligomer. This probe hybridized to a 1.1 kb band in RNA from PE-treated sensitive cells. This RNA was detectable within 3h of PE administration, was clearly visible by 6h, and peaked by 9 to 12h. No bands hybridizing with the IL2 probe were detected in RNA isolated from unstimulated cells or from resistant EL4 cells at any time following PE stimulation. Since levels of the protooncogene c-myc have been shown to decrease in a number of cell lines during differentiation and growth inhibition, total RNA from EL4 cells was probed with a nick-translated plasmid containing the protein coding region of the c-myc gene. In PE sensitive cells, levels of c-myc RNA are markedly reduced by 3h. In a pilot experiment with resistant cells, c-myc levels appeared to remain constant. These results demonstrate that PE induced IL2 mRNA in PE sensitive but not resistant EL4 cells. Sensitive and resistant EL4 cell lines provide a useful model for the investigation of the regulation of gene expression by PE

  15. Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation

    DEFF Research Database (Denmark)

    Chen, C Y; Gherzi, R; Andersen, Jens S.

    2000-01-01

    Regulated mRNA turnover is a highly important process, but its mechanism is poorly understood. Using interleukin-2 (IL-2) mRNA as a model, we described a role for the JNK-signaling pathway in stabilization of IL-2 mRNA during T-cell activation, acting via a JNK response element (JRE) in the 5' un...

  16. Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

    Directory of Open Access Journals (Sweden)

    Ali NM

    2016-06-01

    Full Text Available Norlaily Mohd Ali,1 M Nadeem Akhtar,2 Huynh Ky,3 Kian Lam Lim,1 Nadiah Abu,4 Seema Zareen,2 Wan Yong Ho,5 Han Kiat Alan-Ong,1 Sheau Wei Tan,6 Noorjahan Banu Alitheen,4 Jamil bin Ismail,2 Swee Keong Yeap,6 Tunku Kamarul7 1Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Selangor, 2Department of Industrial Biotechnology, Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, Pahang, Malaysia; 3Department of Agriculture Genetics and Breeding, College of Agriculture and Applied Biology, Cantho University, CanTho City, Vietnam; 4Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 5School of Biomedical Sciences, The University of Nottingham Malaysia Campus, 6Institute of Bioscience, Universiti Putra Malaysia, Selangor, 7Tissue Engineering Group, National Orthopaedic Centre of Excellence for Research and Learning, Department of Orthopaedic Surgery, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia Abstract: Known as naturally occurring biologically active compounds, flavokawain A and B are the leading chalcones that possess anticancer properties. Another flavokawain derivative, (E-1-(2'-Hydroxy-4',6'-dimethoxyphenyl-3-(4-methylthiophenylprop-2-ene-1-one (FLS was characterized with 1H-nuclear magnetic resonance, electron-impact mas spectrometry, infrared spectroscopy, and ultraviolet (1H NMR, EI-MS, IR, and UV spectroscopic techniques. FLS cytotoxic efficacy against human cancer cells (MCF-7, MDA-MB-231, and MCF-10A resulted in the reduction of IC50 values in a time- and dose-dependent mode with high specificity on MCF-7 (IC50 of 36 µM at 48 hours against normal breast cell MCF-10A (no IC50 detected up to 180 µM at 72 hours. Light, scanning electron, and fluorescent microscopic analysis of MCF-7 cell treated with 36 µM of FLS displayed cell shrinkage, apoptotic body, and DNA fragmentation. Additionally, induction of G2/M cell

  17. α2-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC:α2M Levels Are Associated with Venous Thromboembolism.

    Science.gov (United States)

    Martos, Laura; Ramón, Luis Andrés; Oto, Julia; Fernández-Pardo, Álvaro; Bonanad, Santiago; Cid, Ana Rosa; Gruber, Andras; Griffin, John H; España, Francisco; Navarro, Silvia; Medina, Pilar

    2018-04-01

     Activated protein C (APC) is a major regulator of thrombin formation. Two major plasma inhibitors form complexes with APC, protein C inhibitor (PCI) and α 1 -antitrypsin (α 1 AT), and these complexes have been quantified by specific enzyme-linked immunosorbent assays (ELISAs). Also, complexes of APC with α 2 -macroglobulin (α 2 M) have been observed by immunoblotting. Here, we report an ELISA for APC:α 2 M complexes in plasma.  Plasma samples were pre-treated with dithiothreitol and then with iodoacetamide. The detection range of the newly developed APC:α 2 M assay was 0.031 to 8.0 ng/mL of complexed APC. Following infusions of APC in humans and baboons, complexes of APC with α 2 M, PCI and α 1 AT were quantified. These complexes as well as circulating APC were also measured in 121 patients with a history of venous thromboembolism (VTE) and 119 matched controls.  In all the in vivo experiments, α 2 M was a significant APC inhibitor. The VTE case-control study showed that VTE patients had significantly lower APC:α 2 M and APC levels than the controls ( p  APC:α 2 M or the lowest quartile of APC had approximately four times more VTE risk than those in the highest quartile of APC:α 2 M or of APC. The risk increased for individuals with low levels of both parameters.  The APC:α 2 M assay reported here may be useful to help monitor the in vivo fate of APC in plasma. In addition, our results show that a low APC:α 2 M level is associated with increased VTE risk. Schattauer GmbH Stuttgart.

  18. Syntheses and structural characterization of non-centrosymmetric Na{sub 2}M{sub 2}M'S{sub 6} (M, M′=Ga, In, Si, Ge, Sn, Zn, Cd) sulfides

    Energy Technology Data Exchange (ETDEWEB)

    Yohannan, Jinu P.; Vidyasagar, Kanamaluru, E-mail: kvsagar@iitm.ac.in

    2016-06-15

    Seven new non-centrosymmetric Na{sub 2}M{sub 2}M’S{sub 6} sulfides, namely, Na{sub 2}Sn{sub 2}ZnS{sub 6}(1){sub ,} Na{sub 2}Ga{sub 2}GeS{sub 6}(2), Na{sub 2}Ga{sub 2}SnS{sub 6}(3-α), Na{sub 2}Ga{sub 2}SnS{sub 6}(3-β){sub ,} Na{sub 2}Ge{sub 2}ZnS{sub 6}(4){sub ,} Na{sub 2}Ge{sub 2}CdS{sub 6}(5){sub ,} Na{sub 2}In{sub 2}SiS{sub 6}(6) and Na{sub 2}In{sub 2}GeS{sub 6}(7), were synthesized by high temperature solid state reactions and structurally characterized by single crystal X-ray diffraction. They crystallize in non-centrosymmetric Fdd2 and Cc space groups and their three-dimensional [M{sub 2}M′S{sub 6}]{sup 2-}framework structures consist of MS{sub 4} and M′S{sub 4} tetrahedra corner-connected to one another in either orderly or disordered fashion. Sodium ions reside in the tunnels of the anionic framework. Compounds 1, 2 and 3-α have the structure of known Li{sub 2}Ga{sub 2}GeS{sub 6}, whereas compounds 6 and 7 are isostructural with known Li{sub 2}In{sub 2}GeS{sub 6} compound. Isostructural compounds 4 and 5 represent a new structural variant. Compounds 3-α and its new monoclinic structural variant 3-β have disordered structural framework. All of them are wide band gap semiconductors. Na{sub 2}Ga{sub 2}GeS{sub 6}(2), Na{sub 2}Ga{sub 2}SnS{sub 6}(3), Na{sub 2}Ge{sub 2}ZnS{sub 6}(4) and Na{sub 2}In{sub 2}GeS{sub 6}(7) compounds are found to be second-harmonic generation (SHG) active. Compounds 1, 2 and 3-α melt congruently. - Graphical abstract: Na{sub 2}Ga{sub 2}GeS{sub 6}, Na{sub 2}Ga{sub 2}SnS{sub 6}, Na{sub 2}Ge{sub 2}ZnS{sub 6}, Na{sub 2}In{sub 2}GeS{sub 6}, Na{sub 2}Sn{sub 2}ZnS{sub 6}, Na{sub 2}Ge{sub 2}CdS{sub 6} and Na{sub 2}In{sub 2}SiS{sub 6} have non-centrosymmetric structures and the first four compounds are SHG active. Display Omitted - Highlights: • Seven new Na{sub 2}M{sub 2}M′S{sub 6} compounds with non-centrosymmetric structures were synthesized. • They are wide band gap semiconductors. • Na{sub 2}Ga{sub 2}GeS{sub 6}, Na{sub 2

  19. A planet orbiting an sdB star and an M dwarf in 2M 1938+4603

    Directory of Open Access Journals (Sweden)

    Blokesz Adam

    2015-01-01

    Full Text Available We present a preliminary analysis of the 2M 1938+4603 star. It is an eclipsing binary system consisting of a primary sdB component and a secondary M dwarf. The photometric data are dominated by mutual eclipses and a very strong reflection effect. The primary has a fairly rich pulsation spectrum which can be used to study its interior. On the other hand, the pulsations affect the binary trend and vice versa what makes the analysis very difficult. Therefore, we attempted at proper modeling of the light variation due to eclipses and reflection and their removal from the data so it does not affect the Fourier analysis of stellar pulsations. We focus on mid-times of over 16 000 primary and secondary minima, which were used to verify stability of the orbital period. The O-C diagram indicates possible parabolic and sinusoidal variations, commonly explained by period changes caused by evolution and a presence of a third body, respectively.

  20. Experiments on cleaning effects of TDC, GDC and ECR-DC in the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Matsuzaki, Y.; Ogawa, H.; Miura, Y.; Ohtsuka, H.; Suzuki, N.; Yamauchi, T.; Tani, T.; Mori, M.

    1987-01-01

    The cleaning effects of Taylor-type discharge cleaning (TDC), glow discharge cleaning (GDC) and ECR discharge cleaning (ECR-DC) were studied in the JFT-2M tokamak by comparing the properties of resulting tokamak plasmas, by observing the surface composition of samples and by residual gas analysis. The operational parameters of the three discharge cleaning techniques were as follows; the plasma current for TDC is 20 kA, the DC current for GDC is 3 A and the RF power for ECR-DC is 2.3 kW. Parameters of the tokamak plasmas such as loop voltages, radiation losses, spectra emission of oxygen, maximum mean electron densities and profiles of electron temperature were improved as the TDC and ECR-DC proceeded. Changes in the surface composition of samples were measured by Auger electron spectrosopy. The results showed that during the TDC and ECR-DC oxygen was reduced, while GDC reduced mainly carbon. Residual gas analysis performed during discharge cleaning corroborated these results. (orig.)

  1. CH2M Hill Hanford Group, Inc., Standards and Requirements Identification Document (SRID) Requirements Management System and Requirements Specification

    International Nuclear Information System (INIS)

    JOHNSON, A.L.

    2000-01-01

    The current Tank Farm Contractor (TFC) for the U. S. Department of Energy, Office of River Protection (ORP), River Protection Project (RPP), CH2M Hill Hanford Group, Inc. (CHG), will use a computer based requirements management system. The system will serve as a tool to assist in identifying, capturing, and maintaining the Standards/Requirements Identification Document (S/RID) requirements and links to implementing procedures and other documents. By managing requirements as one integrated set, CHG will be able to carry out its mission more efficiently and effectively. CHG has chosen the Dynamic Object Oriented Requirements System (DOORS(trademark)) as the preferred computer based requirements management system. Accordingly, the S/RID program will use DOORS(trademark). DOORS(trademark) will replace the Environmental Requirements Management Interface (ERMI) system as the tool for S/RID data management. The DOORS(trademark) S/RID test project currently resides on the DOORSTM test server. The S/RID project will be migrated to the DOORS(trademark) production server. After the migration the S/RID project will be considered a production project and will no longer reside on the test server

  2. Transport properties of S0.8Se16M0.2 (M = Al, Ag or Cu) system

    International Nuclear Information System (INIS)

    Wahab, L.A.

    2003-01-01

    The results are presented of a study of the electrical and optical properties of vacuum evaporated amorphous thin films in the S 0.8 Se 16 M 0.2 (M=Al, Ag or Cu) system. The activation energy and the pre-exponential factor which appear in the dc conductivity are found to be higher in case of Cu than in case of Ag and Al. The reflectance and transmission are used to measure the optical gap. The glass S 0.8 Se 16 Cu 0.2 behaves as a quasi intrinsic semiconductor (the electrical activation energy is about half of the optical gap). The electrical activation energy is about one-third of the optical gap for the chalcogenide glasses S 0.8 Se 16 Al 0.2 and S 0.8 Se 16 Ag 0.2 . The variation in the refractive index and the imaginary part of the dielectric constant with photon energy have also been reported. The influence of composition on the investigated parameters is reported

  3. The ASTRI SST-2M prototype for the Cherenkov Telescope Array: prototype technologies goals and strategies for the future SST

    Science.gov (United States)

    Marchiori, Gianpietro; Busatta, Andrea; Giacomel, Stefano; Folla, Ivan; Valsecchi, Marco; Canestrari, Rodolfo; Bonnoli, Giacomo; Cascone, Enrico; Conconi, Paolo; Fiorini, Mauro; Giro, Enrico; La Palombara, Nicola; Pareschi, Giovanni; Perri, Luca; Rodeghiero, Gabriele; Sironi, Giorgia; Stringhetti, Luca; Toso, Giorgio; Tosti, Gino; Pellicciari, Carlo

    2014-07-01

    The Cherenkov Telescope Array (CTA) observatory will represent the next generation of Imaging Atmospheric Cherenkov Telescope. Using a combination of large-, medium-, and small-scale telescopes (LST, MST, SST, respectively), it will explore the Very High Energy domain from a few tens of GeVup to about few hundreds of TeV with unprecedented sensitivity, angular resolution and imaging quality. In this framework, the Italian ASTRI program, led by the Italian National Institute of Astrophysics (INAF) developed a 4-meter class telescope, which will adopt an aplanatic, wide-field, double-reflection optical layout in a Schwarzschild- Couder configuration. Within this program INAF assigned to the consortium between Galbiati Group and EIE Group the construction, assembly and tests activities of the prototype named ASTRI SST-2M. On the basis of the lesson learnt from the prototype, other telescopes will be produced, starting from a re-design phase, in order to optimize performances and the overall costs and production schedule for the CTA-SST telescope. This paper will firstly give an overview of the concept for the SST prototype mount structure. In this contest, the technologies adopted for the design, manufacturing and tests of the entire system will be presented. Moreover, a specific focus on the challenges of the prototype and the strategies associated with it will be provided, in order to outline the near future performance goals for this type of Cherenkov telescopes employed for Gamma ray science.

  4. Theoretical investigation of lithium adsorption, diffusion and coverage on MX2 (M = Mo, W; X = O, S, Se, Te) monolayers

    Science.gov (United States)

    Ersan, F.; Ozaydin, H. D.; Gökoğlu, G.; Aktürk, E.

    2017-12-01

    It is important to improve the high-efficient anode materials for Li batteries, which require the large capacity, high stability and mobility. In this work, we present the adsorption and diffusion properties of lithium atom on MX2 (M = Mo, W; X = O, S, Se, Te) transition metal dichalcogenide structures using first principles calculations within density functional theory. All the MX2 systems considered are semiconductor in bare state with band gaps between 0.93 eV (MoO2) and 1.79 eV (WS2). They turn into metal upon single Li adsorption. Li atom is adsorbed on MoO2 and WO2 rather stronger than other systems. The energy barrier for diffusion of single Li on MX2 varies between 0.15 eV and 0.28 eV which are lower or comparable to that of graphene or silicene. Two Li atoms are preferably adsorbed on MX2 monolayer symmetrically at opposite sides with high adsorption energy. The increasing number of Li atoms does not remarkably affect the adsorption energy per Li atom. This can be attributed to that Li atoms do not accumulate on certain regions of the surface. The systems under investigation provide insights into exploring electronic properties which are rather adequate for possible applications in Li-ion batteries.

  5. Histone Modification Is Involved in Okadaic Acid (OA Induced DNA Damage Response and G2-M Transition Arrest in Maize.

    Directory of Open Access Journals (Sweden)

    Hao Zhang

    Full Text Available Histone modifications are involved in regulation of chromatin structure. To investigate the relationship between chromatin modification and cell cycle regulation during plant cell proliferation, Okadaic acid (OA, a specific inhibitor of serine/threonine protein phosphatase, was applied in this study. The results showed that OA caused the cell cycle arrest at preprophase, leading to seedling growth inhibition. Western blotting assay revealed that the spatial distribution of phosphorylation of Ser10 histone H3 tails (H3S10ph signals was altered under OA treatment. Reactive oxygen species (ROS was found to be at higher levels and TdT-mediated dUTP nick end labeling (TUNEL assay displayed DNA breaks happened at the chromatin after treatment with OA, companied with an increase in the acetylation of histone H4 at lysine 5 (H4K5ac level. From these observations, we speculated that the alteration of the spatial distribution of H3S10ph and the level of H4K5ac was involved in the procedure that OA induced DNA breaks and G2-M arrested by the accumulation of ROS, and that the histone H3S10ph and H4K5ac might facilitate DNA repair by their association with the chromatin decondensation.

  6. Exposure of Human Lung Cancer Cells to 8-Chloro-Adenosine Induces G2/M Arrest and Mitotic Catastrophe

    Directory of Open Access Journals (Sweden)

    Hong-Yu Zhang

    2004-11-01

    Full Text Available 8-Chloro-adenosine (8-CI-Ado is a potent chemotherapeutic agent whose cytotoxicity in a variety of tumor cell lines has been widely investigated. However, the molecular mechanisms are uncertain. In this study, we found that exposure of human lung cancer cell lines A549 (p53-wt and H1299 (p53-depleted to 8-CI-Ado induced cell arrest in the G2/M phase, which was accompanied by accumulation of binucleated and polymorphonucleated cells resulting from aberrant mitosis and failed cytokinesis. Western blotting showed the loss of phosphorylated forms of Cdc2 and Cdc25C that allowed progression into mitosis. Furthermore, the increase in Ser10-phosphorylated histone H3-positive cells revealed by fluorescence-activated cell sorting suggested that the agent-targeted cells were able to exit the G2 phase and enter the M phase. Immunocytochemistry showed that microtubule and microfilament arrays were changed in exposed cells, indicating that the dynamic instability of microtubules and microfilaments was lost, which may correlate with mitotic dividing failure. Aberrant mitosis resulted in mitotic catastrophe followed by varying degrees of apoptosis, depending on the cell lines. Thus, 8-CI-Ado appears to exert its cytotoxicity toward cells in culture by inducing mitotic catastrophe.

  7. E2mC: Improving Emergency Management Service Practice through Social Media and Crowdsourcing Analysis in Near Real Time

    Science.gov (United States)

    Francalanci, Chiara; Scalia, Gabriele; Fernandez-Marquez, Jose Luis; Van Achte, Tim; Zeug, Gunter; Mondardini, Maria Rosa (Rosy); Grandoni, Domenico; Kirsch, Birgit; Kalas, Milan; Lorini, Valerio; Rüping, Stefan

    2017-01-01

    In the first hours of a disaster, up-to-date information about the area of interest is crucial for effective disaster management. However, due to the delay induced by collecting and analysing satellite imagery, disaster management systems like the Copernicus Emergency Management Service (EMS) are currently not able to provide information products until up to 48–72 h after a disaster event has occurred. While satellite imagery is still a valuable source for disaster management, information products can be improved through complementing them with user-generated data like social media posts or crowdsourced data. The advantage of these new kinds of data is that they are continuously produced in a timely fashion because users actively participate throughout an event and share related information. The research project Evolution of Emergency Copernicus services (E2mC) aims to integrate these novel data into a new EMS service component called Witness, which is presented in this paper. Like this, the timeliness and accuracy of geospatial information products provided to civil protection authorities can be improved through leveraging user-generated data. This paper sketches the developed system architecture, describes applicable scenarios and presents several preliminary case studies, providing evidence that the scientific and operational goals have been achieved. PMID:29186080

  8. DDAH2 mRNA expression is inversely associated with some cardiovascular risk-related features in healthy young adults.

    Science.gov (United States)

    Puchau, Blanca; Hermsdorff, Helen Hermana M; Zulet, M Angeles; Martínez, J Alfredo

    2009-01-01

    The purpose of this study was to evaluate whether the mRNA expression profiles of three genes (PRMT1, DDAH2 and NOS3) are related to ADMA metabolism and signalling, and the potential relationships with anthropometrical, biochemical, lifestyle and inflammatory indicators in healthy young adults. An emphasis on the putative effect of different mRNA expression on cardiovascular risk-related features was paid. Anthropometrical measurements as well as lifestyle features were analyzed in 120 healthy young adults. Fasting blood samples were collected for the measurement of glucose and lipid profiles as well as the concentrations of selected inflammatory markers. Profiles of mRNA expression were assessed for PRMT1, DDAH2 and NOS3 genes from peripheral blood mononuclear cells. Regarding inflammatory biomarkers, DDAH2 was inversely associated with IL-6 and TNF-alpha. Moreover, subjects in the highest quintile of DDAH2 mRNA expression showed a reduced risk to have higher values of waist circumference, and to be more prone to show higher values of HDL-c. Interestingly, DDAH2 gene expression seemed to be related with some anthropometrical, biochemical, lifestyle and inflammatory indicators linked to cardiovascular risk in apparently healthy young adults, emerging as a potential disease marker.

  9. DDAH2 mRNA Expression Is Inversely Associated with Some Cardiovascular Risk-Related Features in Healthy Young Adults

    Directory of Open Access Journals (Sweden)

    Blanca Puchau

    2009-01-01

    Full Text Available The purpose of this study was to evaluate whether the mRNA expression profiles of three genes (PRMT1, DDAH2 and NOS3 are related to ADMA metabolism and signalling, and the potential relationships with anthropometrical, biochemical, lifestyle and inflammatory indicators in healthy young adults. An emphasis on the putative effect of different mRNA expression on cardiovascular risk-related features was paid. Anthropometrical measurements as well as lifestyle features were analyzed in 120 healthy young adults. Fasting blood samples were collected for the measurement of glucose and lipid profiles as well as the concentrations of selected inflammatory markers. Profiles of mRNA expression were assessed for PRMT1, DDAH2 and NOS3 genes from peripheral blood mononuclear cells. Regarding inflammatory biomarkers, DDAH2 was inversely associated with IL-6 and TNF-α. Moreover, subjects in the highest quintile of DDAH2 mRNA expression showed a reduced risk to have higher values of waist circumference, and to be more prone to show higher values of HDL-c. Interestingly, DDAH2 gene expression seemed to be related with some anthropometrical, biochemical, lifestyle and inflammatory indicators linked to cardiovascular risk in apparently healthy young adults, emerging as a potential disease marker.

  10. Peculiarities of the intermediate valence state of Ce in CeM2Si2 (M = Fe, Co, Ni) compounds

    International Nuclear Information System (INIS)

    Koterlyn, M.; Shcherba, I.; Yasnitskii, R.; Koterlyn, G.

    2007-01-01

    The results of thermoelectric power and the electrical resistivity measurements connected with the intermediate valence (IV) of Ce are presented for the compounds CeM 2 Si 2 (M = Fe, Co, Ni) in the temperature range of 4-800 K. It is shown that CeM 2 Si 2 are Kondo-lattices with the coherence scale T coh ∼ 60-80 K and the so-called single-site Kondo temperature T K ∼ 10 3 K. On the example of CeNi 2 Si 2 we have studied the changes in the structure of density of f states (f-DOS) near the Fermi energy caused by atomic substitutions. The results of structural, transport, magnetic, and Ce L III X-ray absorption spectra measurements in the series Ce 1-x La x Ni 2 Si 2 (0 ≤ x ≤ 0.6), Ce(Ni 1-y Cu y ) 2 Si 2 (0 ≤ y ≤ 0.6) and CeNi 2 (Si 1-z Ge z ) 2 (0 ≤ z ≤ 0.5) are presented. We found that the IV state of Ce in the CeM 2 Si 2 is an evidence of possible opening a wide pseudogap Δ ∼ kT K within the f-DOS structure slightly above the Fermi energy

  11. 14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.

    Directory of Open Access Journals (Sweden)

    Dashnamoorthy Ravi

    2011-01-01

    Full Text Available In vitro cell culture experiments with primary cells have reported that cell proliferation is retarded in the presence of ambient compared to physiological O₂ levels. Cancer is primarily a disease of aberrant cell proliferation, therefore, studying cancer cells grown under ambient O₂ may be undesirable. To understand better the impact of O₂ on the propagation of cancer cells in vitro, we compared the growth potential of a panel of ovarian cancer cell lines under ambient (21% or physiological (3% O₂.Our observations demonstrate that similar to primary cells, many cancer cells maintain an inherent sensitivity to O₂, but some display insensitivity to changes in O₂ concentration. Further analysis revealed an association between defective G2/M cell cycle transition regulation and O₂ insensitivity resultant from overexpression of 14-3-3 σ. Targeting 14-3-3 σ overexpression with RNAi restored O₂ sensitivity in these cell lines. Additionally, we found that metastatic ovarian tumors frequently overexpress 14-3-3 σ, which in conjunction with phosphorylated RB, results in poor prognosis.Cancer cells show differential proliferative sensitivity to changes in O₂ concentration. Although a direct link between O₂ insensitivity and metastasis was not determined, this investigation showed that an O₂ insensitive phenotype in cancer cells to correlate with metastatic tumor progression.

  12. Determination of formation constants of hydroxo carbonate complexes of Pr3+ in 2M NaCl at 303 K

    International Nuclear Information System (INIS)

    Lopez G, H.D.

    1996-01-01

    The hydrolysis of Praseodymium III in 2M sodium chloride at 303 K was studied. Two methods were used: pH titration followed by a computational refinement and solvent extraction in the presence of a competitive ligand. The hydrolysis constants obtained by pH titration were: log β 1,H = -7.68 ± 0.07, log β 1,2H = -15.10 ± 0.03, and β 1,3H -23.8 ± 0.04. The stability constants of Praseodymium carbonates were determined by pH titration as well and were: log β 1,CO3 2- = 5.94 ± 0.08 and log β 1,2CO3 2- = 11.15 ± 0.15. Praseodymium carbonate species were taken into consideration for calculating the first hydrolysis constants by the solvent extraction method and the value obtained was: log β 1,H = -7.69 ± 0.27. The values for log β 1,H attained by both methods are the same. The species-distribution diagram was obtained from the stability constants of Praseodymium carbonates and hydrolysis products in the conditions of the present work. (Author)

  13. Review: study of single-pellet injection experiments and development of pellet injector in JFT-2M

    International Nuclear Information System (INIS)

    Kasai, Satoshi; Miura, Yukitoshi; Hasegawa, Kouichi; Sengoku, Seio

    1987-10-01

    The single pellet injector developed for JFT-2M and the improvement of plasma characteristics in the auxiliary-heated discharges by single-pellet injection are reviewed for the period 1982 - 1986. The pellet injector is a pneumatic type and the designed pellet size is 1.65 mmD x 1.65 mmL and 1 mmD x 1 mmL. The hydrogen, deuterium and mixed (H 2 + D 2 ) pellets can be produced with good reproducibility. Maximum pellet velocity is about 970 m/s (pellet is deuterium and propellant gas is hydrogen). In the pellet injection experiments into auxiliary-heated (NB, ICRF) divertor or limiter discharges, the plasma confinement time is improved by a factor of 1.4 - 1.7 compared with the confinement time in the Ohmic discharges. The achieved confinement time is longer than that on the high confinement mode (H-mode) in gas fueled discharges, although the phenomena are transient. (author)

  14. Pipes out of the chromium-molybdenum 12Kh2M1 steel intended for power units

    International Nuclear Information System (INIS)

    Saf'yanov, A.V.; Plyatskovskij, O.A.; Khokhlov-Nekrasov, O.G.; Palatnikova, E.S.; Karpenko, N.P.

    1977-01-01

    Vanadiumless steel 12Kh2M1 (2.25%Cr, 1%Mo) known to be applied abroad has been used for production of 325x60 mm tubes. The technology involves heating of the blanks to 1270-1300 deg C, their piercing in a double-roller mill, rolling on a pilger mill 8-16'' in thick wall caliber rolls, thermal treatment (normalizing at 930-960 deg C for 1 hour and tempering at 730+-10 deg C for 4 hours and etching (12-22% H 2 SO 4 and up to 143 g/l FeSO 4 ) for 3-4 hours at 55-65 deg C. Good technological properties of the steel and its capacity of working at 540-580 deg C are confirmed. Vanadium alloying of boiler steels does not provide for essential improvement of oxydation resistance and long term strength, but decreases the workability and enhances scatter of working parameters on account of minor variations of chemical composition

  15. Study in aqueous solution of the praseodymium inclusion in β-cyclodextrin in 2 M of NaCl; Estudio en solucion acuosa de la inclusion del praseodimio en la β-ciclodextrina en 2 M de NaCl

    Energy Technology Data Exchange (ETDEWEB)

    De la Cruz M, N.

    2013-07-01

    In the fission of uranium to produce electricity, generated between the fission products which are the lanthanides and actinides that at any given time may come into contact with aqueous media, because of this, praseodymium was including in the β-cyclodextrin in order to increase the solubility and stability of praseodymium by forming inclusion complexes Praseodymium-β-cyclodextrin (Pr-β-Cd). The inclusion study was conducted in a proportion of praseodymium and β-cyclodextrin. Infrared spectra, Raman and X-ray diffraction showed the presence of praseodymium and β-cyclodextrin in the inclusion complex, in both proportions. The analysis by scanning electron microscopy confirmed the inclusion of praseodymium in βcyclodextrin. In general, the results of characterization obtained by these techniques show the formation of the inclusion complex. Furthermore, the behaviour of praseodymium inclusion in the β-cyclodextrin was studied in 2 M NaCl at 303 K and free-CO{sub 2} conditions. For this reason, we used two methods: spectrophotometric and potentiometric titration direct of praseodymium-β-cyclodextrin, the data were treated graphically and with the program SUPERQUAD, respectively. The values obtained for praseodymium by spectrophotometric method was: log β{sub 1}= -8.75 calculated graphically and with the potentiometric method, using program SUPERQUAD were logβ{sub 1,OH}= -8.73 ± 0.01 logβ{sub 1,2OH}= -18.27 ± 0.16 and logβ{sub 1,3OH}= -26.44 ± 0.02 obtained simultaneously. (Author)

  16. Dilemas políticos y de orden público: Alcaldías y fuerzas de seguridad en disturbios etnicistas Dilemas políticos y de orden público: Alcaldías y fuerzas de seguridad en disturbios etnicistas

    Directory of Open Access Journals (Sweden)

    MANUEL ÁNGEL Río Ruiz

    2005-01-01

    Full Text Available A través de entrevistas y de la explotación de diversas fuentes documentales, se analiza el papel de autoridades locales y fuerzas de seguridad en localidades españolas donde, se han producido casos de violencia colectiva focalizados en miembros de minorías culturales estigmatizadas, como gitanos e inmigrantes. Las ilustraciones desplegadas, analizadas atendiendo a los hallazgos sustantivos de la literatura sociológica e historiográfica sobre relaciones interétnicas y represión estatal de la protesta, muestran la frecuente inobservancia, por parte de los dispositivos estatales de coerción, de principios básicos de la moderna doctrina de la represión preventiva que, en cambio, sí se aplican de manera recurrente a la hora del manejo policial de otras protestas sociales. A su vez, en lo que respecta a las autoridades municipales, el análisis muestra las constricciones que encuentran estas agencias de control y poder comunitario a la hora de la contención de multitudes etnicistas. El análisis revela que la posición de puente entre las dos comunidades que ocupan las autoridades locales, así como la frecuente implicación de los alcaldes en los agravios y tensiones que anteceden a los conflictos, limita la eficacia de éstos en el manejo pacífico de protestas e iniciativas colectivas etnicistas a las que, por otra parte, ediles de diverso signo político han prestado, a veces, una colaboración planeada o sobrevenida, como sucediera en los casos de Mancha Real o El Ejido, también abordados aquíThis paper analyses the role of local authorities and police forces in the development of several cases of collective violence against stigmatised minorities, such as gypsies and immigrants, that have taken place in Spain during the last two decades. The research is based in ethnographical interviews and secondary sources. The several cases are analysed taking into account the sociological and historical literature that deal with inter

  17. Carcinoma associated fibroblasts (CAFs) promote breast cancer motility by suppressing mammalian Diaphanous-related formin-2 (mDia2).

    Science.gov (United States)

    Dvorak, Kaitlyn M; Pettee, Krista M; Rubinic-Minotti, Kaitlin; Su, Robin; Nestor-Kalinoski, Andrea; Eisenmann, Kathryn M

    2018-01-01

    The tumor microenvironment (TME) promotes tumor cell invasion and metastasis. An important step in the shift to a pro-cancerous microenvironment is the transformation of normal stromal fibroblasts to carcinoma-associated fibroblasts (CAFs). CAFs are present in a majority of solid tumors and can directly promote tumor cell motility via cytokine, chemokine and growth factor secretion into the TME. The exact effects that the TME has upon cytoskeletal regulation in motile tumor cells remain enigmatic. The conserved formin family of cytoskeleton regulating proteins plays an essential role in the assembly and/or bundling of unbranched actin filaments. Mammalian Diaphanous-related formin 2 (mDia2/DIAPH3/Drf3/Dia) assembles a dynamic F-actin cytoskeleton that underlies tumor cell migration and invasion. We therefore sought to understand whether CAF-derived chemokines impact breast tumor cell motility through modification of the formin-assembled F-actin cytoskeleton. In MDA-MB-231 cells, conditioned media (CM) from WS19T CAFs, a human breast tumor-adjacent CAF line, significantly and robustly increased wound closure and invasion relative to normal human mammary fibroblast (HMF)-CM. WS19T-CM also promoted proteasome-mediated mDia2 degradation in MDA-MB-231 cells relative to control HMF-CM and WS21T CAF-CM, a breast CAF cell line that failed to promote robust MDA-MB-231 migration. Cytokine array analysis of CM identified up-regulated secreted factors in WS19T relative to control WS21T CM. We identified CXCL12 as a CM factor influencing loss of mDia2 protein while increasing MDA-MB-231 cell migration. Our data suggest a mechanism whereby CAFs promote tumor cell migration and invasion through CXCL12 secretion to regulate the mDia2-directed cytoskeleton in breast tumor cells.

  18. Congruence of Home, Social and Sex Neighborhoods among Men Who Have Sex with Men, NYCM2M Study.

    Science.gov (United States)

    Koblin, Beryl A; Egan, James E; Nandi, Vijay; Sang, Jordan M; Cerdá, Magdalena; Tieu, Hong-Van; Ompad, Danielle C; Hoover, Donald R; Frye, Victoria

    2017-06-01

    Substantial literature demonstrates the influence of the neighborhood environment on health behaviors and outcomes. But limited research examines on how gay and bisexual men experience and exist in various geographic and virtual spaces and how this relates to their sexual behavior. New York City Men 2 Men (NYCM2M) was a cross-sectional study designed to identify neighborhood-level characteristics within the urban environment that influence sexual risk behaviors, substance use, and depression among men who have sex with men (MSM) living in NYC. The sample was recruited using a modified venue-based time-space sampling methodology and through select websites and mobile applications. Whether key neighborhoods of human activity, where a participant resided (termed home), socialized (termed social), or had sex most often (termed sex), were the same or different was evaluated. "Congruence" (or the sameness) of home, social, and most often sex neighborhood was reported by 17 % of men, while 30 % reported that none of their neighborhoods were the same. The largest group of men (39 %) reported that their home and sex neighborhoods were the same but their social neighborhood was different while 10 % reported that their home neighborhood was different than their social and sex neighborhood; 5 % men reported same home and social neighborhoods with a different sex neighborhood. Complete neighborhood incongruence was highest among men who were Black and/or Latino, had lower education and personal income levels, and had greater financial insecurity. In adjusted analysis, serodiscordant condomless anal intercourse and condomless anal intercourse with partners from the Internet or mobile applications were significantly associated with having the same social and sex (but not home) neighborhoods. Understanding the complexity of how different spaces and places relate to the health and sexual behavior of MSM is essential for focusing interventions to best reach various populations

  19. A Subpopulation of the K562 Cells Are Killed by Curcumin Treatment after G2/M Arrest and Mitotic Catastrophe.

    Directory of Open Access Journals (Sweden)

    Macario Martinez-Castillo

    Full Text Available Curcumin is extensively investigated as a good chemo-preventive agent in the development of many cancers and particularly in leukemia, including treatment of chronic myelogenous leukemia and it has been proposed as an adjuvant for leukemia therapies. Human chronic myeloid leukemia cells (K562, were treated with 20 μM of curcumin, and we found that a subpopulation of these cells were arrested and accumulate in the G2/M phase of the cell cycle. Characterization of this cell subpopulation showed that the arrested cells presented nuclear morphology changes resembling those described for mitotic catastrophe. Mitotic cells displayed abnormal chromatin organization, collapse of the mitotic spindle and abnormal chromosome segregation. Then, these cells died in an apoptosis dependent manner and showed diminution in the protein levels of BCL-2 and XIAP. Moreover, our results shown that a transient activation of the nuclear factor κB (NFκB occurred early in these cells, but decreased after 6 h of the treatment, explaining in part the diminution of the anti-apoptotic proteins. Additionally, P73 was translocated to the cell nuclei, because the expression of the C/EBPα, a cognate repressor of the P73 gene, was decreased, suggesting that apoptosis is trigger by elevation of P73 protein levels acting in concert with the diminution of the two anti-apoptotic molecules. In summary, curcumin treatment might produce a P73-dependent apoptotic cell death in chronic myelogenous leukemia cells (K562, which was triggered by mitotic catastrophe, due to sustained BAX and survivin expression and impairment of the anti-apoptotic proteins BCL-2 and XIAP.

  20. Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes.

    Science.gov (United States)

    Jeng, J H; Ho, Y S; Chan, C P; Wang, Y J; Hahn, L J; Lei, D; Hsu, C C; Chang, M C

    2000-07-01

    There are about 600 million betel quid (BQ) chewers in the world. BQ chewing is associated with increased incidence of oral cancer and submucous fibrosis. In this study, areca nut (AN) extract (200-800 microg/ml) induced the prostaglandin E(2) (PGE(2)) production by 1. 4-3.4-fold and 6-keto-PGF(1 alpha) production by 1.1-1.7-fold of gingival keratinocytes (GK), respectively, following 24 h of exposure. Exposure of GK to AN extract (>400 microg/ml) led to cell retraction and intracellular vacuoles formation. At concentrations of 800 and 1200 microg/ml, AN extract induced cell death at 21-24 and 32-52% as detected by MTT assay and cellular lactate dehydrogenase release, respectively. Interestingly, AN-induced morphological changes of GK are reversible. GK can still proliferate following exposure to AN extract. Cytotoxicity of AN extract cannot be inhibited by indomethacin (1 microM) and aspirin (50 microM), indicating that prostaglandin (PG) production is not the major factor responsible for AN cytotoxicity. PGE(2) exhibited little effect on the growth of GK at concentrations ranging from 100-1000 pg/ml. Stimulating GK production of PGs by AN extract could be due to induction of cyclooxygenase-2 (COX-2) mRNA expression and protein production. These results suggest that AN ingredients are critical in the pathogenesis of oral submucous fibrosis and oral cancer via their stimulatory effects on the PGs, COX-2 production and associated tissue inflammatory responses. AN cytotoxicity to GK is not directly mediated by COX-2 stimulation and PG production.