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Sample records for fuerza ionica 1m

  1. Solubility of La, Pr, Eu, Er and Lu in a media of 1M ionic force of NaCl by 303 K; Solubilidad de La, Pr, Eu, Er y Lu en medio de fuerza ionica 1M de NaCl, a 303 K

    Ramirez G, J.J.; Solache R, M.J.; Jimenez R, M.; Rojas H, A. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2002-07-01

    The solubility and the solubility product of La, Pr, Eu, Er and Lu in media of 1M ionic force of NaCl by 303 K was determined, by means of a radiochemical method and the pLn{sup -}pCH diagrams in free conditions of CO{sub 2} were constructed. Moreover, the non saturation and the saturated zones and with them the pCH precipitation bound were determined. Finally a comparison among the obtained data in this work and those reported in the literature in several media was realized. (Author)

  2. Effect of the ion force on the hydrolysis constants and of the solubility product of Europium; Efecto de la fuerza ionica sobre las constantes de hidrolisis y del producto de solubilidad del europio

    Jimenez R, M.; Ramirez G, J.J.; Solache R, M.; Rojas H, A. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2003-07-01

    A study on the behavior of the first hydrolysis constant {beta}{sub Eu,H}{sup l-0} and the constant of the solubility product Kps of the europium in front of the changes of the ion force: 0. 02 M, 0.1 M, 0.7M, 2M, 3M and 4M of sodium perchlorate, at 303 K. Experimentally the potentiometry and also radioactivity measures its were used. The specific interaction of ions theory (SIT) of Bronsted-Guggenheim-Scatchard allows the extrapolation of the values to infinite dilution and the results were: log {beta}{sub Eu,H}{sup l-0} = -7 36 and log K{sub sp}{sup l-0} = -24. 68. A discussion of the group of results with the data of the literature is presented. (Author)

  3. Chemical species of europium (III) in ionic force media 0.02M, 0.1M, and 0.7M NaClO{sub 4} at 298 K; Especies quimicas del europio (III) en medios de fuerza ionica 0.02M, 0.1M y 0.7M NaClO{sub 4} a 298 K

    Fernandez R, E.; Jimenez R, M.; Solache R, M. [Instituto Nacional de Investigaciones Nucleares, Departamento de Quimica, A.P. 18-1027, C.P. 11801 Mexico D.F. (Mexico)

    2000-07-01

    In order to know the effects of the controlled or accidental liberation of the europium in the environment, it is necessary to know its chemical behavior in found conditions in oceans, ground and surface water. The behavior of this element in these environments can be controlled mainly by the hydrolysis and its interaction with inorganic and organic ions. (Author)

  4. Fuerza primitiva y fuerza derivativa

    Leonardo Ruiz

    2015-06-01

    Full Text Available La fuerza derivativa es descrita por Leibniz como modificación o limitación de la entelequia o fuerza primitiva. Sin embargo, la describe también como perteneciente a los fenómenos y como causante del movimiento físico. Algunos comentadores han encontrado en este punto un conflicto irresoluble dentro del sistema leibniziano, mientras que otros han ensayado algunas soluciones. Este artículo presenta un análisis de la noción de “modo”, tal como es utilizada en la descripción de la relación entre fuerza primitiva y fuerza derivativa. A partir de este análisis, realizaré una crítica de las lecturas de dos comentadores que tratan sobre este tema y trataré de dar, finalmente, una explicación de cómo la fuerza derivativa puede pertenecer a los fenómenos siendo, a la vez, una modificación de la entelequia. Esto puede ser de gran ayuda para comprender las relaciones entre metafísica y dinámica en la filosofía leibniziana.

  5. La fuerza normal: ¿una fuerza conservativa?

    Díaz-Solórzano, S.; González-Díaz, L.

    2011-01-01

    La fuerza normal es una fuerza de ligadura que surge del contacto entre un objeto y una superficie. Esta fuerza puede conservar la energía mecánica de un sistema o no. Se muestra que dicha fuerza es conservativa cuando la superficie no evoluciona en el tiempo, así como la tasa a la cual varía la energía mecánica cuando la fuerza normal es no conservativa. Para esta última situación, se propone la función energía pseudo-potencial asociada a la fuerza normal con la finalidad de obtener la ecuac...

  6. FUERZA DE LA LEY

    Guido Leonardo Croxatto

    2015-09-01

    Full Text Available Se presenta un análisis de un texto de Jacques Derrida, Fuerza de la ley. El fundamento místico de la autoridad, en el cual el autor analiza, como indica el título del ensayo, los fundamentos (narraciones, e ideas en que se basa la autoridad del Derecho. Se busca cruzar el análisis que lleva adelante Derrida de las obras de autores como Pascal, Montaigne, Walter Benjamin, Kafka, con las preguntas actuales de la filosofía legal, como ser el basamento (meramente conjetural, hipotético, presupuesto de la norma fundamental de Kelsen o la vinculación entre el Derecho y la Moral, el Derecho y la Justicia, el Derecho y la violencia. El punto central a que se dedica el autor es interrogar el concepto de violencia. Trata de precisar quién, por qué y cómo detenta el máximo poder: el poder de nombrar qué es lo que es violento. Y qué es lo que no. “¿Que diferencia hay entre la fuerza de la ley y la mera violencia que consideramos injusta?” Esta es la pregunta fundamental que inspira el texto de Derrida, pero también es la pregunta que ha inspirado desde siempre a los abogados.

  7. Entrenamiento de fuerza para la salud

    Ortiz Cervera, Vicente

    1996-01-01

    Este artículo describe de manera breve y clara los efectos del entrenamiento de fuerza sobre la salud, al mismo tiempo da pautas para la realización y programación de los entrenamientos de fuerza para la salud en distintas edades. Se muestran las diferentes variables del entrenamiento de la fuerza junto con ejemplos de entrenamientos, basándose en las pautas marcadas en la revisión bibliográfica descrita.

  8. Formas estructurales de fuerza constante

    Zalewski, Waclaw

    1963-05-01

    Full Text Available The author seeks to prove the need to obtain the most essential form in the various types of structures by applying a number of rational principles, of which the constant stress principle is one of the most decisive. The structural form should be a logical consequence of all its functional circumstances, and this requires a clear understanding of the general behaviour of each part of the structure, and also of the main stresses which operate on it, considered as a unitary whole. To complete his theoretical argument, the author gives some examples, in the design of which the criterion of constant stress has been adopted. The author considers the various aspects which are involved in obtaining a structural design that satisfies given functional and aesthetic requirements. In doing so he refers to his personal experience within Poland, and infers technical principles of general validity which should determine the rational design of the form, as an integrated aspect of the structural pattern. The projects which illustrate this paper are Polish designs of undoubted constructive significance, in which the principle of constant stress has been applied. Finally the author condenses his whole theory in a simple and straightforward practical formula, which should be followed if a truly rational form is to be achieved: the constancy of stress in the various structural elements.El autor se esfuerza en mostrar la necesidad de llegar a la forma real en las distintas estructuras siguiendo una serie de principios racionales, entre los que domina el criterio de la fuerza constante. La forma ha de ser una consecuencia lógica en todos sus aspectos, y esto exige un claro conocimiento del comportamiento general de cada una de las partes de la estructura, y de los esfuerzos generales que dominan en la misma al considerarla como un todo. Para completar la exposición de orden teórico, el autor presenta algunos ejemplos en cuyo proyecto se ha seguido el criterio de

  9. Fuerza lumbar en jugadores de hockey hierba

    Til Pérez, Lluís; Barceló Peiró, Oriol; Pomés Díes, Teresa; Martínez Navas, Roberto; Galilea Ballarini, Pedro; Bellver Vives, Montserrat

    2007-01-01

    Introducción: El dolor lumbar tiene una alta prevalencia entre los deportistas, se ha relacionado con déficits en la fuerza extensora lumbar, y el hecho de padecerlo representa un obstáculo importante para la práctica de deportes de alta intensidad. Método: Se ha medido la fuerza lumbar en 2 grupos de practicantes de hockey hierba mediante máquina MedX® y un test de resistencia isométrico lumbar. Resultados: Entre ambos grupos los resultados han sido muy homogéneos....

  10. Ion nitriding post-oxidation as an alternative technique to electrolytic chromium; Nitruracion post-oxidacion ionica como tecnica alternativa al cromado electrolitico

    Diaz-Guillen, J. C.; Granda-Gutierrez, E.E.; Campa-Castilla, A.; Perez-Aguilar, S.I.; Garza-Gomez, A.; Candelas-Ramirez, J.; Mendez-Mendez, R. [COMIMSA. Corporacion Mexicana de Investigacion en Materiales S.A. de C.V., Saltillo, Coahuila (Mexico)]. E-mail: jcarlos@comimsa.com

    2010-11-15

    The effect of temperature and processing time during post-oxidation on hardness and corrosion resistance of AISI 1045 samples treated through nitriding and post-oxidation in a pulsed plasma discharge is evaluated in this paper. Also, a comparative analysis of the mechanical properties obtained with the dual nitriding - post oxidation process versus those properties of typical hard chrome coatings was performed with an aim to propose an alternative technique to the processes of galvanic coatings. The latter revealed that the process of ion nitriding and post-oxidation provides similar properties in hardness and improves the corrosion resistance compared to the hard chrome case. It is conclude that the technique of ion nitriding and post-oxidation is a non environmental harmful technology with strong potential to replace highly polluting electroplating techniques for application of hard chrome coatings. [Spanish] En el presente trabajo se evalua el efecto del tiempo y la temperatura de post-oxidacion sobre las propiedades de dureza y resistencia a la corrosion de muestras de acero AISI 1045 sometido al proceso de nitruracion post-oxidacion ionica en plasmas pulsados. Asi mismo, con el objetivo de fundamentar la propuesta de utilizacion de la nitruracion post-oxidacion ionica como una tecnica alternativa a los procesos galvanicos para aplicacion de recubrimientos de cromo duro, se realizo un analisis comparativo de propiedades, evidenciando que, mediante el proceso nitruracion postoxidacion ionica, es posible obtener caracteristicas similares en dureza y mejores en resistencia a la corrosion que las tipicas obtenidas para el cromo duro. Los resultados obtenidos permiten postular una tecnica que no dana al medio ambiente, como lo es la nitruracion post-oxidacion ionica, como candidata potencial para sustituir las tecnicas galvanicas altamente contaminantes para aplicacion de cromo duro.

  11. Fuerza manual de adultos con discapacidad intelectual

    Ruth Cabeza Ruiz

    2017-09-01

    Full Text Available Objetivo. Presentar una descripción de la fuerza de prensión manual de hombres y mujeres con discapacidad intelectual (DI y comparar los resultados con valores de referencia de otras personas con y sin discapacidad intelectual. Método. El presente trabajo es un estudio transversal observacional, financiado por la Fundación SAMU, en el que se evaluaron a 122 personas con DI (86 hombres y 36 mujeres durante el desarrollo de unas jornadas de carácter recreativo en las que participaron varias asociaciones de atención a este colectivo. La batería de test utilizada fue el Alpaha-Fit Test Battery for Adults. Resultados. Se presentan los resultados relacionados con las variables de fuerza del miembro superior (Hand Grip Strength por grupos de edad (20-24, 25- 29, 30-34, 35-39, 40-44, 45-49, 50-54, 55-59 años. Los datos muestran valores que oscilan desde los 31 kg en los hombres más jóvenes con DI hasta los 13.3 kg del grupo más maduro de mujeres. Estos hallazgos son similares a los valores de referencia de población con DI española. Sin embargo, son muy inferiores a los obtenidos por la población sin discapacidad de la misma edad. Conclusión. Los resultados evidencian el menor rendimiento de las personas con DI en pruebas de fuerza de prensión manual por lo que se hace evidente la necesidad de llevar a cabo programas de ejercicio físico o deporte con las personas con DI.

  12. El entrenamiento de fuerza en la natación

    Irigaray Martín, Javier

    2014-01-01

    Existen numerosos estudios que demuestran la importancia del entrenamiento de fuerza en la mejora del rendimiento en la natación. El objetivo del entrenamiento de fuerza en natación es por tanto buscar la transferencia en rendimiento de la natación de competición. Sin embargo, aunque los estudios hayan mostrado mejoras significativas con el entrenamiento de fuerza, no se ha demostrado que exista una transferencia específica. No obstante, su introducción en el programa de ent...

  13. Entrenamiento de la fuerza en el fútbol

    Olivares Ruiz, Alejandro

    2014-01-01

    El “Entrenamiento de la Fuerza en el Fútbol” consta de cuatro capítulos: en un primer punto, conoceremos los objetivos que persigue este trabajo, que son, resumidamente, analizar la importancia del entrenamiento de la fuerza en el fútbol, saber qué manifestación de la fuerza conviene más trabajar en este deporte, y conocer y comparar las metodologías de entrenamiento más utilizadas. Por otro lado, en este primer apartado también se argumentará por qué debe trabajarse esta cuali...

  14. Entrenamiento de fuerza y salud pediátrica

    Faigenbaum, Avery D.; Myer, Gregory D.

    2011-01-01

    Aunque muchos médicos y jóvenes entrenadores consideran que el entrenamiento de fuerza es potencialmente peligroso e inseguro para el sistema músculo esquelético en desarrollo, una gran cantidad de evidencias científicas indican que este tipo de entrenamiento es seguro, efectivo y constituye una metodología adecuada para niños y jóvenes siempre que se sigan las indicaciones apropiadas. Los programas de entrenamiento de fuerza para niños y jóvenes, si son adecuadamente diseñados y supervisados...

  15. Effect of the chloride ions on the hydrolysis of praseodymium in a 2M ion force media; Efecto de los iones cloruro sobre la hidrolisis del praseodimio en medio de fuerza ionica 2M

    Lopez G, H.; Jimenez R, M.; Solache R, M.; Rojas H, A. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2004-07-01

    The constants of the product of solubility and the first of hydrolysis were determined of the Praseodymium in media 2M of NaClO{sub 4} and 2M of NaCl, to 303 K and under conditions free of CO{sub 2}. The diagram of solubility was obtained (pPr{sub (ac)} - pC{sub H}), by means of a radiochemical method and with it was established the pC{sub H} that limit the saturation and non saturation areas; that diagram allowed, also, to calculate the constant of the product of solubility. Also, it was adjusted with the polynomial of solubility equation, that it allowed to determine and to check the values of the constants of the product of solubility and the first of hydrolysis. Independently, it was determined the first constant of hydrolysis of the element, by means of potentiometric titrations whose data were treated with the computer program named SUPERQUAD and with the adjustment of the equation of the average number of bonds. It was also calculates the log constant {beta}{sub Pr,Cl} of the specie PrCI{sup 2+} starting from the hydrolysis constants obtained in the perchlorate and chloride media. (Author)

  16. Fuerza de ventas determinante de la competitividad empresarial

    Noelia Isabel León Valbuena

    2013-01-01

    Full Text Available El objetivo de este artículo es describir como la fuerza de ventas influye dentro y fuera de la organización empresarial para alcanzar la competitividad. Para ello se vincula la labor de la fuerza de ventas en la cadena de valor, y se estudia este importante eslabón de la cadena. La metodología utilizada es documental o bibliográfica. Se parte del supuesto de que la fuerza de ventas es la encargada de interrelacionar el entorno interno y externo de la organización, produciendo el ingreso necesario para el inicio y fin del ciclo productivo, a través de la realización de diversas actividades. Se concluye que para alcanzar los objetivos empresariales y la competitividad, es vital contar con una excelente fuerza de ventas; representativa de un factor de cambio y diferenciación de las organizaciones hacia el logro y permanencia de una empresa competitiva.

  17. Ionic propulsion; Propulsion ionica

    Velarde, G

    1972-07-01

    The inner parameters (electrons and ions velocity, current, thrust, power; specific impulse) and the outer parameters (velocity and operating time) of an ion propellant rocket are studied. The components (chamber dimensions, weights, propellants,) are also described. (Author) 5 refs.

  18. Propuestas para el entrenamiento combinado de fuerza y resistencia

    López de Viñaspre, Pablo; Comellas, Josep

    2000-01-01

    Muchas especialidades deportivas requieren de un buen nivel de entrenamiento tanto en la capacidad de fuerza como en la de resistencia. Por este motivo, se incluye el entrenamiento combinado de estas dos cualidades en el programa de entrenamiento de muchos deportistas. Por otro lado, en el deporte recreativo, el concepto del Fitness es ya común entre la mayoría de la población y va tomando cada vez más importancia. Actualmente se busca el bienestar global (tendencia del Wellness) a través de ...

  19. La modernización de las Fuerzas Armadas

    Serra, Eduardo

    2014-02-01

    Full Text Available This article briefly reviews the recent history of the Spanish Armed Forces, stressing the importance of the military institution and its role in contemporary Spanish history. Following Franco’s death there was an attempt to bring the command of the Armed Forces under democratic control within the constitution, a process in which General Gutiérrez Mellado played a crucial role. Since 1981, two important measures have been taken in the military sphere: “case 2/81”, prosecuting the perpetrators of the attempted coup in 1981, and Spain’s application to join the Atlantic Alliance (NATO, a very important step in shaping the country’s future and driving the modernisation of the Spanish Armed Forces, putting them on an equal footing with their peers elsewhere in the Western world. After the socialist victory in 1982, the PSOE government changed direction, skilfully transforming its initial anti-Americanism, obtaining Spain’s membership of NATO following the 1986 referendum, and profoundly changing the Armed Forces, thus eliminating military tensions. The last stage of the modernisation process was led by Aznar’s government, with the professionalisation of the Armed Forces and the integration of Spain in NATO’s military structure.El artículo realiza un breve repaso por la historia de las Fuerzas Armadas españolas destacando la importancia de la institución militar y su papel en la Historia contemporánea española. Desde de la muerte de Franco se intenta por encauzar a los mandos de las Fuerzas Armadas en la senda democrática y constitucional, siendo entonces crucial el papel del General Gutiérrez Mellado. A partir de 1981, se toman dos importantes medidas en la esfera militar: la llamada causa 2/81, para el enjuiciamiento de los responsables de la intentona golpista y la solicitud de ingreso de España en la Alianza Atlántica, paso muy importante que determinará el futuro del país y permitió la modernización de las Fuerzas

  20. Elecciones presidenciales peruanas 2016: La fuerza del antifujimorismo

    Andrés Ernesto Ferrari Haines

    2016-09-01

    Full Text Available El presente artículo analiza el proceso electoral presidencial peruano del año 2016. La segunda vuelta electoral fue disputada entre Pedro Pablo Kuczynski y Keiko Fujimori Higuchi. Fujimori Higuchi es hija del ex-presidente Alberto Fujimori quien cumple una condena de 25 años en prisión por violación a los derechos humanos y corrupción. En este análisis se destaca el papel que ejerció la izquierda peruana en el triunfo de Pedro Pablo Kuczynski. Diversas fuerzas políticas junto con una gran movilización ciudadana se manifestaron a favor de la candidatura de Kuczynski como una muestra del voto antifujimorista.

  1. The distribution systems of the Luz y Fuerza del Centro; Sistemas de distribucion en Luz y Fuerza del Centro

    Espinosa y Lara, Roberto [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

    1997-12-31

    In this document are described the distribution systems that have been utilized in Mexico, to satisfy the electric energy demand. Mention is made of the areas of influence these systems have, its structure, the electric infrastructure that Luz y Fuerza del Centro has to satisfy the demand and in this way be in position of planning the distribution networks. As in other activities the aspects related to the protection of the environment exert a growing influence on the development of the energy sector, for this reason three themes are mentioned to which special attention must be paid. A table is shown with the per capita consumption, another one with the number of transformers and its capacity. Also the underground networks in operation and under construction are shown and a flow diagram of the distribution system planning [Espanol] En este documento se describen los sistemas de distribucion que se han realizado en Mexico, para satisfacer la demanda electrica, se mencionan las areas de influencia que tienen estos sistemas, su estructuracion, la infraestructura electrica con la que cuenta Luz y Fuerza del Centro para satisfacer las demandas y asi poder planear las redes de distribucion. Como en otras actividades, los aspectos relacionados con el cuidado del ambiente ejercen una influencia creciente sobre el desenvolvimiento del sector de energia, es por eso que se mencionan tres temas a los que se les debe de poner especial atencion. Se muestra una tabla de consumo per capita, otra del numero de transformadores y su capacidad. Tambien se ilustran las redes subterraneas en operacion y construccion y un flujograma de planeacion del sistema de distribucion

  2. Déficit bilateral de las manifestaciones de la fuerza muscular de las extremidades inferiores en estudiantes universitarios

    Ramón Candia-Luján; Karen Ileana Carreón Santa Cruz; Beatriz Anai Núnez Escudero; Lidia Guillermina De León Fierro; Claudia Esther Carrasco Legleu

    2018-01-01

    El objetivo del estudio fue determinar el déficit bilateral (DBL) de las manifestaciones de la fuerza muscular de los miembros inferiores en estudiantes universitarios, participaron16 hombres y 14 mujeres. Se les evaluó la fuerza máxima dinámica, la potencia muscular y la fuerza isométrica, en forma bilateral y unilateral de ambas extremidades inferiores. La suma de la fuerza máxima dinámica unilateral de las extremidades inferiores fue mayor que la fuerza bilateral 132,4 ± 38,1 kg y 114,6 ± ...

  3. Estudio de los efectos del envejecimiento en la fuerza muscular y en el equilibrio

    Barrena Aizcorbe, Oihane

    2011-01-01

    Objetivos: -Identificar cambios en la fuerza (máxima isométrica y explosiva) y en el equilibrio dinámico de las extremidades inferiores en las articulaciones de (caderas, rodilla y tobillo) entre los jóvenes y las personas mayores. -Determinar la relación existente la disminución de la fuerza a nivel de las extremidades inferiores y del equilibrio asociados a la edad. Material y métodos: Se ha realizado un estudio descriptivo transversal para determinar la fuerza máxima isométrica y explosiva...

  4. Programación del entrenamiento de la fuerza en el voleibol juvenil

    Kolevich, Alejandro

    2011-01-01

    El trabajo intentará abordar las manifestaciones de la fuerza que predominan durante un partido de voleibol de nivel de liga nacional. Así pues, se buscará caracterizar el deporte y analizar los tiempos de juego, para poner en consideración si las fuerzas que aparecen son las más recomendadas a desarrollar con entrenamiento de sobrecarga o si resultaría necesario trabajar otra manifestación de la fuerza que no aparece en el juego mismo. De esta forma, la programación del ejercicio mostr...

  5. Current Status of TRR-1/M1

    Sittichai, Chaiyut

    2000-01-01

    In 1961, the first Thai Research Reactor, TRR-1, having power of 1 MW was established. It was located at Office of Atomic Energy for Peace (OAEP) in Bangkok. TRR-1 was completely commissioned in June 1962. Plate typed high-enriched uranium (HEU) and U 3 O 8 -Al were used as fuel. Light water used as moderator and coolant. During 1975-1977, TRR-1 was shut down for modification. The reactor core and control system were disassembled and replaced by TRIGA Mark III. It is a circular hexagonal core typed reactor designed by General Atomics Company (GA). Afterwards, TRR-1 was officially renamed to Thai Research Reactor 1/Modification 1 (TRR-1/M1). TRR-1/M1 is a multipurpose reactor with nominal power of 2 MW. This swimming pool typed reactor uses low-enriched uranium (LEU) as fuel and light water as coolant and moderator. To date, the reactor has been operated with core No.12 that released power 1135 MWD to serve the user. The reactor has been serving for various kinds of utilization, for example, to produce radioisotope, neutron beam experiments and reactor physics experiments. This report explains in detail regarding operational experience and current status of this reactor, for example, reactor operation and reactor utilization. (author)

  6. Simuladores para entrenamientos en la Fuerza Aérea Colombiana

    José Fernando Sizza Moreno

    2014-01-01

    Full Text Available La simulación es una técnica que compromete ingeniería de software, ingeniería mecánica e ingeniería electrónica, además de emulación, que definen los modelos matemáticos para dotar a una máquina especificaciones funcionales, para la apariencia en tiempo real de comportamientos idénticos a los de su contraparte a imitar. Asimismo, emular es una reproducción de las operaciones de otro, intentando igualarlas e incluso excederlas. De esta manera, una máquina se dota con la simulación y la emulación en tiempo real, diseñando máquinas capaces de imitar y remedar otras, sin los riesgos, humanos o de infraestructura que involucra en la realidad, con la emulación acorde con la máquina a igualar. El entrenamiento puede ejecutarse en este tipo de máquinas, para proporcionar y evaluar las habilidades necesarias a desarrollarse en la vida real, con el fin de disminuir los costos y los tiempos que implican. Es así que el objetivo de este artículo es proporcionar una visión sobre simuladores aeronáuticos puestos en práctica en la Fuerza Aérea Colombiana.

  7. The KEK 1 m hydrogen bubble chamber

    Doi, Yoshikuni; Araoka, Osamu; Hayashi, Kohei; Hayashi, Yoshio; Hirabayashi, Hiromi.

    1978-03-01

    A medium size hydrogen bubble chamber has been constructed at the National Laboratory for High Energy Physics, KEK. The bubble chamber has been designed to be operated with a maximum rate of three times per half a second in every two second repetition time of the accelerator, by utilizing a hydraulic expansion system. The bubble chamber has a one meter diameter and a visible volume of about 280 l. A three-view stereo camera system is used for taking photographic pictures of the chamber. A 2 MW bubble chamber magnet is constructed. The main part of the bubble chamber vessel is supported by the magnet yoke. The magnet gives a maximum field of 18.4 kG at the centre of the fiducial volume of the chamber. The overall system of the KEK 1 m hydrogen bubble chamber facility is described in some detail. Some operational characteristics of the facility are also reported. (auth.)

  8. ¿La fuerza puede predecir el rendimiento y la lesionabilidad en el baloncesto profesional?

    Toni Caparrós Pons

    2014-12-01

    Full Text Available Con el objetivo de conocer las relaciones existentes entre la fuerza, el rendimiento deportivo y la lesionabilidad en un equipo masculino de baloncesto profesional, se realiza un estudio prospectivo, observacional y descriptivo de análisis de estadísticas (71 partidos, test de media sentadilla (n = 7 y patología lesional, monitorizando la temporada 09/10, donde se relacionan los datos obtenidos de cada jugador referentes al rendimiento deportivo por partido (valoración estadística, las medias de fuerza, velocidad y potencia de cada mesociclo y la lesionabilidad. La técnica estadística utilizada ha sido la correlación a partir del parámetro rho de Spearman. Estas correlaciones entre fuerza y lesionabilidad muestran que a valores de fuerza más elevados hay más lesiones: con 80 kg son muy significativas para lesiones totales (LT y potencia (rho = 0,898; p = 0,006, y significativas por fuerza (rho = 0,823; p = 0,023 y velocidad (rho = 0,774; p = 0,041; la velocidad con 90 kg se relaciona con lesiones time loss (TL (rho = 0,878; p = 0,009, y la potencia con 100 kg, con lesiones totales (LT (rho = 0,805; p = 0,029 y V100 (rho = 0,898; p = 0,006 muy significativamente. En conclusión, durante la ejecución de la media sentadilla, hay valores de fuerza acordes para rendir más y lesionarse menos: de 800 N a 1050 N y con cargas de 80 kg a 90 kg.

  9. Efectos de un programa de entrenamiento de fuerza sobre la composición corporal y la fuerza máxima en jóvenes entrenados

    Torres Luque, Gema; Ponce de León, Facundo; Orquín Castrillón, Francisco Javier

    2009-01-01

    El objetivo de este estudio fue conocer las adaptaciones en composición corporal, fuerza máxima y resistencia muscular local de un programa de entrenamiento de fuerza en circuito intermitente con sobrecargas. Método: Se seleccionaron 8 varones jóvenes entrenados en musculación (24,07 ± 3,12 años, 77,96 ± 7,5 kg, 173 ± 0,2 cm y 14,50 ± 2,00 meses de experiencia). Todos los sujetos firmaron un consentimiento por escrito de participación. Se realizó una valoración antropométrica, 10 tests de ...

  10. Efectos de un programa de entrenamiento de fuerza sobre la composición corporal y la fuerza máxima en jóvenes entrenados

    Torres Luque, Gema; Orquín Castrillón, Francisco; Ponce de León, Facundo

    2009-01-01

    El objetivo de este estudio fue conocer las adaptaciones en composición corporal, fuerza máxima y resistencia muscular local de un programa de entrenamiento de fuerza en circuito intermitente con sobrecargas. Método: Se seleccionaron 8 varones jóvenes entrenados en musculación (24,07 ± 3,12 años, 77,96 ± 7,5 kg, 173 ± 0,2 cm y 14,50 ± 2,00 meses de experiencia). Todos los sujetos firmaron un consentimiento por escrito de participación. Se realizó una valoración antropométrica, 10 tests de una...

  11. RELACIÓN ENTRE DIFERENTES PRUEBAS DE CAMPO: FUERZA, POTENCIA Y VELOCIDAD

    Jessenia Hernández Elizondo

    2003-01-01

    Esta investigación tuvo como propósito principal el encontrar por medio de pruebas en las variables de fuerza, potencia y velocidad, la relación matemática existente entre estos tres constructos. Participaron 56 sujetos varones con edades entre 18 y 25 años. Con el fin de responder al objetivo del estudio, se les aplicaron pruebas de campo de fuerza (1RM de sentadilla completa y repeticiones máximas al 80% 60% 40% y 20%), de velocidad (30 metros lanzados y 30 metros sin impulso), y de potenci...

  12. Control de las fuerzas de fresado mediante actuadores piezoeléctricos

    Diez Cifuentes, Eduardo

    2010-01-01

    Resumen El alabeo de la herramienta y sus efectos constituyen una importante línea de investigación dentro del modelado, simulación y control de fuerzas de corte en fresado. El alabeo de la herramienta hace que los filos corten de manera desigual, por lo que las fuerzas de corte sobre cada filo resultan diferentes. Esto afecta la vida de la herramienta y deteriora la calidad superficial de la pieza. En este trabajo se propone un procedimiento para disminuir los efectos del alabeo de la herram...

  13. Fuerzas Ortodóncicas como Agentes Vulnerantes de la Salud Pulpar: Reporte de Dos Casos

    Fonseca, Gabriel M; Guzmán, Andrés E

    2010-01-01

    La literatura ya ha sugerido la implicancia del uso de fuerzas ortodóncicas como productoras de daño mecánico, reacción inflamatoria periodontal, lesión periapical y reabsorción radicular. Los parámetros más comúnmente explorados en investigaciones de la respuesta tisular a fuerzas ortodónticas consisten en medir los niveles de oxígeno pulpar, la vasculatura y los cambios en la circulación sanguínea. Se ha demostrado que la irrigación pulpar disminuye tempranamente cuando se realizan aplicaci...

  14. Ajuste de la fuerza de infección del dengue

    Aldana-Bermúdez, Eliécer; Restrepo-Triviño, Maribel; Muñoz-Loaiza, Aníbal

    2017-01-01

    RESUMEN Objetivo Plantear un modelo matemático hospedero vector para el ajuste de la fuerza de infección del dengue en una población variable con crecimiento logístico y ciclo de vida del mosquito con tasa de ovoposición periódica, considerando inmunidad a un serotipo. Métodos El modelo matemático propuesto está representado por ocho ecuaciones diferenciales a las que se les calcula la fuerza de infección por el método de las redes libres de escala. Resultados Se presenta una simulación...

  15. Apocalissi teosofiche in Las fuerzas extrañas di Leopoldo Lugones

    Camilla Cattarulla

    2013-06-01

    Full Text Available In 1906 the Argentinian author Leopoldo Lugones published Las fuerzas extranas. In this collection of short stories Lugones places his interests in spiritism and science at the service of fiction and modernist prose. Lugones furthermore embraces aesthetically the theosophic doctrine envisaging a quest for absolute perfection through a process of renewal and reincarnation of the individual; it is within this framework that a number of apocalyptic episodes found in Las fuerzas extrañas are to be interpreted, pointing as they do in an intertextual game to specific Biblical passages which illustrate the theosophic stand of the author.

  16. Entrenamiento de la fuerza en la mujer= Strength trainning in women

    Garc??a del Castillo, Diego

    2016-01-01

    Este trabajo de revisi??n bibliogr??fica sobre el entrenamiento de la fuerza en las mujeres, va encaminado a concienciar de la igualdad que existe en los efectos y beneficios que ambos sexos. Estas falsas creencias son producto de y que a??n perduran en la actualidad de forma injustificada. Por tanto e trabajo es conseguir establecer en la sociedad entrenamiento de la fuerza causa en la figura entre sexos para poder relacionar conceptos y aclarar estos mitos de los que ha...

  17. Planificación del entrenamiento de fuerza en natación

    Pérez de Blas, Laura

    2014-01-01

    La principal función del siguiente trabajo es facilitar el proceso de diseño de un programa de entrenamiento de fuerza para nadadores, mediante la exposición de los diferentes aspectos a tener en cuenta en dicho proceso, y la propuesta de un ejemplo de programación. El trabajo de fuerza forma parte integrada del entrenamiento de nadadores para diferentes edades y niveles, pero por las características especiales en las que se desarrolla este deporte, se hace preciso un conoci...

  18. The evolution of the Luz y Fuerza del Centro substations. Volume 2; Evolucion de las subestaciones de Luz y Fuerza del Centro. Volumen 2

    Carranza Ramirez, Sergio [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

    1997-12-31

    This document cites historical background of how the Luz y Fuerza del Centro substations have evolved up to nowadays. A brief description is made of one electric substation, the substation design criteria are mentioned, since it must comply with the requirements of reliability, service continuity, service quality, economy, geographical location, just for mentioning some of them. The more utilized arrangements of the Luz y Fuerza del Centro substations are described. In the same manner, the remote control substations are described mentioning the main elements of this type of substations. Mention is made also of the technological incorporations that have been made to the substations and the perspectives there are from these. One line diagrams of the electric substations are shown, as well as from power plant substations [Espanol] Este documento cita antecedentes historicos de como han evolucionando las subestaciones de Luz y Fuerza del Centro hasta hoy en dia. Se realiza una breve descripcion de una subestacion electrica, se mencionan los criterios de diseno de una subestacion, ya que debe cumplir con los requisitos de confiabilidad, continuidad, calidad del servicio, economia, situacion geografica, por mencionar algunos de estos. Se describen los arreglos de las subestaciones mas utilizados por Luz y Fuerza del Centro. De igual manera se describen las subestaciones telecontroladas mencionando los principales elementos de este tipo de subestaciones. Se mencionan las incorporaciones tecnologicas que se han realizado a las subestaciones y las perspectivas que se tienen de estas. Se muestran diagramas unifilares de subestaciones electricas, al igual que se muestran las plantas de las subestaciones

  19. Manual de entrenamiento de la fuerza en el fútbol. La planificación del trabajo de fuerza en un equipo

    Ruiz Madrid, Álvaro

    2014-01-01

    En este proyecto final de grado se va a conceptualizar la importancia del entrenamiento de la fuerza en un equipo de fútbol actualmente, así como los diferentes métodos de trabajo y sus consecuencias. Seguidamente veremos un ejemplo de planificación de una temporada de fútbol realizando un estudio previo de la entidad y posteriormente el desarrollo de la planificación.

  20. Efectos de un entrenamiento concurrente de fuerza y resistencia sobre carreras de media distancia

    Juan Manuel García-Manso

    2017-01-01

    Full Text Available El objetivo de este estudio fue evaluar los efectos del entrenamiento concurrente (fuerza y resistencia sobre las carreras de media distancia en sujetos jóvenes de moderado nivel de rendimiento. Se aplicó un trabajo organizado en fases de diferente orientación de fuerza, lo que se conoce como periodización por bloques. Quince universitarios sanos y físicamente activos participaron voluntariamente en el estudio. Fueron organizados aleatoriamente en dos grupos: uno que entrenaba solo resistencia (Grupo Resistencia: GR: Edad=21.3±2.3 años; Peso Corporal=66.8±1.9 kg; Estatura=172.0±2.3 cm; Grasa Corporal=10.8±1.1% y otro (Grupo Fuerza-Resistencia: GFR: Edad=20.9±1.2 años; Peso Corporal=69.8±1.3 kg; Estatura=172.8±3.9 cm, Grasa Corporal=11.4±0.6% al que se le añadió un protocolo de entrenamiento de fuerza de 9 semanas (2 días/semana de duración. No se detectaron grandes diferencias en los cambios observados en ambos grupos al final de las nueve semanas. Los dos grupos mejoraron significativamente su rendimiento en las carreras de media y larga duración, la fuerza, la resistencia de fuerza y su capacidad aeróbica (VO2 max. Los cambios fueron poco apreciables en el resto de las pruebas evaluadas (60 y 300 metros. Los mayores beneficios se encontraron en la carrera de 2000 metros. Dichas mejoras se detectaron desde el primer mesociclo de entrenamiento y fueron especialmente evidentes al final de las nueve semanas. No obstante, no se detectaron diferencias relevantes entre ambos grupos (6.5±3.7 vs. 3.7±2.1 ml/kg/min; F=0.534; IC95%= -0.198, 5.932; p=0.65; ES=0.434. En conclusión, podemos afirmar que en esta muestra incorporar un trabajo de fuerza no conlleva mayores beneficios que entrenar solo la carrera.

  1. Estimación de la fuerza de contacto para el control de robots manipuladores con movimientos restringidos

    Javier Gámez García

    2007-01-01

    Full Text Available Resumen: En aquellas operaciones robóticas en las que un robot manipulador interactúa con su entorno resulta de extremada importancia poder controlar la fuerza que aquél ejerce sobre este. Con este objetivo, se suele colocar habitualmente un sensor de fuerza en la muñeca del manipulador, cerrando de esta forma el lazo de control. En lo que se refiere a estos sensores, uno de los principales problemas que plantean es que sus medidas están influenciadas no sólo por las fuerzas de contacto, sino también por las fuerzas relacionadas con la dinámica de la herramienta del manipulador, es decir, las fuerzas de inercia. En este artículo se presenta un nuevo estimador de la fuerza de contacto consistente en la integración de la información de sensores de fuerza, posición y aceleración. Además, se describe un procedimiento de calibración automático ‘plugand-play’ para la identificación y ajuste de los parámetros de este observador. Tanto el observador de la fuerza de contacto como el procedimiento de calibración automático han sido verificados experimentalmente en un robot industrial ABB con arquitectura software abierta. Palabras clave: Control de fuerza en robots manipuladores, Fusión sensorial, Observadores, Calibración Automática

  2. Estudio de la influencia de un programa de entrenamiento de la fuerza en diferentes factores de rendimiento, en jugadores de golf de ??lite

    ??lvarez Plaza, Mar??a

    2011-01-01

    157 p. El prop??sito del presente estudio es determinar los efectos de un programa de entrenamiento de fuerza de 18 semanas de duraci??n, dividido en tres partes, sobre las caracter??sticas antropom??tricas, la fuerza explosiva de las extremidades inferiores, rendimiento con el drive, la fuerza m??xima y la fuerza isom??trica de agarre (grip) en jugadores de ??lite masculinos. La hip??tesis es que, tras el programa de entrenamiento de fuerza, de 18 semanas de duraci??n, real...

  3. Efectos de diferentes protocolos de entrenamiento de fuerza sobre la fuerza máxima, la velocidad, la saltabilidad y el equilibrio en estudiantes universitarios

    Naclerio Ayllón, Fernando José; Marín, Pedro J.; Viejo Romero, David; Forte Fernández, Daniel

    2007-01-01

    El objetivo de este estudio es comparar los efectos de tres medios de entrenamiento sobre la fuerza máxima, la saltabilidad, la velocidad y el equilibrio en 24 varones estudiantes universitarios (21.5 ±1.7 años, 1.72± 0.06 m y 75.5±8.7 kg) que entrenaron durante 6 semanas con una frecuencia de 3 veces por semana, realizando 3 ejercicios: sentadilla paralela (SP), split frontal (SF) y extensiones de cadera (EC), siguiendo una periodización creciente-decreciente. Los sujetos fueron divididos en...

  4. Evaluación del desempeño de la fuerza de ventas

    Rivera Camino, Jaime; Molero Ayala, Víctor

    1997-01-01

    Este artículo presenta la aplicación de una metodología nueva (Delphi Goal y Data Envelopment Analysis) para buscar la solución de un problema antiguo: la evaluación del desempeño de la fuerza de ventas. Nuestra propuesta teórica se presenta como una guía para las investigaciones que buscan enriquecer el conocimiento sobre el desempeño de la fuerza de ventas. Aunque el reconocimiento de la problemática de la evaluación de ventas no es nuevo, los métodos tradicionales tienden a evaluar el dese...

  5. Strategi Counterinsurgency Kolombia terhadap Farc (Fuerzas Armadas Revolucionarias De Colombia) 2010-2012

    Olivia, Yessi; Miranda, Dea

    2014-01-01

    This paper is analysing about counterinsurgency Colombia to against paramilitary group in Colombia to help address the humanitarian crisis that occurred because of civil conflict in Colombia. Conflict in Colombia involving the Fuerzas Armadas Revolucionaries de Colombia (FARC) and the Government of Colombia is one example of a threat to human security in this case is a citizen of Colombia. Thousands of people confirmed dead, and hundreds more injured and displaced into the surrounding area. C...

  6. Efectos del entrenamiento de fuerza con distintas intensidades relativas y nivel de rendimiento inicial sobre las respuestas neuromuscular y hormonal

    Otero Esquina, Carlos

    2017-01-01

    Programa de Doctorado en Actividad Física, Rendimiento Deportivo y Salud El objetivo de la presente tesis doctoral fue comprobar los efectos de dos tipos de entrenamiento de fuerza distintos en intensidad e igualados en volumen en el ejercicio de sentadilla completa sobre la respuesta neuromuscular y hormonal. Para ello se realizaron 3 estudios en los que se analizaron: Estudio 1: Efectos del entrenamiento de fuerza con distintas intensidades sobre la mejora en la capacidad de salto, e...

  7. Dramatic Rewritings of the Spanish Golden Age Theater of Cervantes´s La fuerza de la sangre

    Juan Manuel Escudero Baztán

    2013-12-01

    Full Text Available This paper analyzes the Golden age spanish theater recreations of Cervantes’s exemplary novel La fuerza de la sangre. Specifically, the paper reviews three important stages in these recreations: La fuerza de la sangre of Guillen de Castro, El agravio satisfecho de Castillo Solórzano, and No hay cosa como callar de Calderon de la Barca. Different rewrites indicate a close relationship between the three dramatic texts through intertextuality and other influences.

  8. Atribuciones sobre el uso de la fuerza policial desde la perspectiva del agente

    Julián Martínez

    2014-08-01

    Full Text Available Se describen los contenidos de los procesos atribucionales asociados al uso de la fuerza en agentes de la Policía de la Provincia de Córdoba, Argentina. Los antecedentes indican que, además de los marcos legales, existen sistemas de creencias, valores, actitudes, definiciones morales, aspectos situacionales y una cultura institucional, que operan en los policías al momento de usar la fuerza. Mediante entrevistas en profundidad a 10 agentes policiales de la Provincia de Córdoba, hallamos dimensiones atributivas externas e internas, que a su vez guardan relación con el tipo de trabajo policial según éste sea bajo órdenes o sin ellas. También identificamos relaciones entre dichas dimensiones y diferentes niveles de fuerza que se aplican. Esta investigación cobra importancia por su abordaje psicosocial que prioriza la comprensión de las dimensiones subjetivas de los agentes, evitando explicar la práctica policial únicamente como un mecanismo para el control del orden social y político.

  9. Determination of formation constants of hydroxo carbonate complexes of Pr{sup 3+} in 2M NaCl at 303 K; Determinacion de las constantes de hidrolisis y de los complejos con carbonatos del Praseodimio (III), en medio de fuerza ionica 2M de cloruro de sodio, a 303 K

    Lopez G, H D

    1997-12-31

    The hydrolysis of Praseodymium III in 2M sodium chloride at 303 K was studied. Two methods were used: pH titration followed by a computational refinement and solvent extraction in the presence of a competitive ligand. The hydrolysis constants obtained by pH titration were: log {beta}{sub 1,H} = -7.68 {+-} 0.07, log {beta}{sub 1,2H} = -15.10 {+-} 0.03, and {beta}{sub 1,3H} -23.8 {+-} 0.04. The stability constants of Praseodymium carbonates were determined by pH titration as well and were: log {beta}{sub 1,CO3}{sup 2-} = 5.94 {+-} 0.08 and log {beta}{sub 1,2CO3}{sup 2-} = 11.15 {+-} 0.15. Praseodymium carbonate species were taken into consideration for calculating the first hydrolysis constants by the solvent extraction method and the value obtained was: log {beta}{sub 1,H} = -7.69 {+-} 0.27. The values for log {beta}{sub 1,H} attained by both methods are the same. The species-distribution diagram was obtained from the stability constants of Praseodymium carbonates and hydrolysis products in the conditions of the present work. (Author).

  10. Determination of the hydrolysis constants of Europium (III), in ion strength media 4, 5 and 6 M NaClO{sub 4} at 303 K; Determinacion de las constantes de hidrolisis del Europio (III), en medios de fuerza ionica 4, 5 y 6 M de NaClO{sub 4} a 303 K

    Alvarado B, A.; Jimenez R, M.; Solache R, M. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1999-07-01

    This work was made with the purpose to complete information about the hydrolysis constants of Europium (III) in high ion strength media. So it was determined at a ion forces media 4, 5 and 6 M of sodium perchlorate at 303 K. The method used was the potentiometric with the aid of the Super quad computer program. In high ion strength media, the measurements of p H do not correspond directly to negative logarithm of the concentration of hydrogen ions, by this it is necessary to calibrate the electrode in these conditions. The Europium was hydrolized at pC{sub H} values greater 6 in all cases. The potentiometric method used under the described experimental conditions is adequate to determine the hydrolysis constants of Europium (III). According to the results and diagrams of chemical species of Europium obtained we can conclude that the hydrolysis constants, differ by its distribution but not in its identity. (Author)

  11. 2008 - Color & Infrared (4 band) - Statewide NAIP (1m)

    Vermont Center for Geographic Information — (Link to Metadata) The NAIP_1M_CLRIR_2008 dataset is a 1:40000 scale (1 meter) truecolor and infrared (4 band) NAIP imagery product acquired during the summer of...

  12. 2014 - Color & Infrared (4 band) - Statewide NAIP (1m)

    Vermont Center for Geographic Information — (Link to Metadata) The NAIP_1M_CLRIR_2014 dataset is a (1 meter) truecolor and infrared (4 band) NAIP imagery product acquired during the summer of 2014 by the...

  13. On the HL-1M tokamak plasma confinement time

    Qin Yunwen

    2001-01-01

    Emphasizing that the tokamak plasma confinement time is the plasma particle or thermal energy loss characteristic time, the relevant physical concept and HL-1M tokamak experimental data analyses are reviewed

  14. The computer code EURDYN-1M (release 2). User's manual

    1982-01-01

    EURDYN-1M is a finite element computer code developed at J.R.C. Ispra to compute the response of two-dimensional coupled fluid-structure configurations to transient dynamic loading for reactor safety studies. This report gives instructions for preparing input data to EURDYN-1M, release 2, and describes a test problem in order to illustrate both the input and the output of the code

  15. Diagramas de energía, fuerza y materia = Diagrams of energy, force and matter

    Josep Maria Montaner

    2013-10-01

    Full Text Available ResumenEn este ensayo se va a tratar sobre arquitectura a partir de la definición de forma como “estructura esencial e interna, como construcción del espacio y de la materia”. Para ello, podemos establecer, como punto de partida, que el proceso de la arquitectura va de la energía, las fuerzas y la materia hacia la forma. Por tanto, teorizar sobre la forma en arquitectura nos lleva a reflexionar sobre tres fenómenos previos a su configuración: la energía, las fuerzas y la materia. Para seguir estos procesos físicos es útil remitirse al pensamiento postestructuralista de Gilles Deleuze y Félix Guattari, especialmente a su texto Mil Mesetas. Capitalismo y esquizofrenia (1980 y a conceptos como “rizoma” y “agenciamiento” y, sobre todo, utilizar la herramienta interpretativa y creativa del “diagrama”.Palabras claveenergía, fuerza, materia, forma, Deleuze, GuattariAbstractThis essay will deal on architecture from the defi nition of form as "critical and internal structure  as construction of space and matter." For that, we can establish, as a starting point, that the process of architecture goes from energy, forces and matter to form. Thus, theorizing about form in architecture leads us to refl ect on three prior phenomena to its confi guration: energy, forces and matter. To follow these physical processes is useful to refer the poststructuralist thought´s Gilles Deleuze and Felix Guattari, especially his text A Thousand Plateaus. Capitalism and Schizophrenia (1980 and concepts such as "rhizome" and "assemblage" and, above all, to use the creative and interpretative tool of "diagramme".Key wordsenergy, force, matter, form, Deleuze, Guattari

  16. Dinámica de la fuerza de trabajo en Cuba 1846-1931 (II

    Orestes Gárciga Gárciga

    2014-06-01

    Full Text Available En «Dinámica de la fuerza de trabajo en Cuba 1846-1931» se estudia el procesamiento de los datos estadísticos que, acerca de la actividad laboral de la población, presentaron los censos de 1846, 1862, 1899, 1907, 1919 y 1931. Debido a su extensión, la obra ha sido dividida en tres partes para ser publicada en Novedades en Población. El presente artículo examina la evolución de la fuerza de trabajo en Cuba de 1846 a 1931, a través de diversas clasificaciones internacionales empleadas en estos estudios, y da continuidad a «Dinámica de la fuerza de trabajo en Cuba 1846-1931 (I», incluido en el número anterior de la revista (Año 9, Número 17, 2013. Abstract In «Dynamic of the workforce in Cuba 1846-1931» is studied the processing of statistical data showed by the 1846, 1862, 1899, 1907, 1919 and 1931 censuses about labor activity of the population. Due to its extension, this work has been divided in three parts so it can be published in Novedades en Población (News on Population. The current paper reviews the evolution of the work force in Cuba from 1846 to 1931, taking to account diverse international classifications used in this studies. It is the continuation of «Dynamic of the workforce in Cuba 1846-1931 (I», included in the previous number of this magazine.

  17. Mercado laboral y capital social en un contexto de alta movilidad de fuerza de trabajo.

    Romo Genoy, Edgardo

    2015-01-01

    Esta investigación tiene como objetivo principal dar cuenta del mercado laboral y el nivel de capital social en un contexto de alta movilidad de fuerza de trabajo. Para este propósito se toma el caso de estudio en el corregimiento de Chiles, municipio de Cumbal (Colombia) ubicado en la frontera colombo ecuatoriana. En primer lugar se aborda el tema de investigación definiendo el mercado desde la perspectiva de Karl Polanyi, según la cual “el mercado” no se explica únicamente en acontecimiento...

  18. Estudio prospectivo de la ciberdefensa en las Fuerzas Armadas del Ecuador

    Castro Peralvo, Edwin Javier

    2015-01-01

    Las guerras en la actualidad toman otra dimensión, ya no se trata de las clásicas operaciones que se desarrollan en el campo de batalla con las tradicionales armas de las Fuerzas Armadas y sus soldados enfrentándose por ocupar un territorio, actualmente se desarrolla otro tipo de guerra en otro escenario que es el ciberespacio. Existen ejemplos reales que se han desarrollado ciberguerras entre algunos países como el de Rusia y Estonia en el año 2007, Estonia fue atacada su infraestructura crí...

  19. La comunicación en las fuerzas de seguridad del Estado

    María de las Mercedes Cancelo San Martín

    2014-12-01

    Full Text Available La búsqueda de legitimización social de las instituciones es una de las claves de la comunicación institucional. Independiente de su actividad organizacional la comunicación debe ser la nueva interpretación del concepto de responsabilidad social. Existe un deber: el de comunicar, pues en cualquier sociedad democrática toda actividad organizacional empieza con el consentimiento del público y éste debe saber si las fuerzas de seguridad cumplen las funciones para las que fueron creadas. Presenta algunos estudios de caso.

  20. Insuficiencia normativa sobre roles y funciones para los miembros de la Fuerza Pública

    Morales Hernández, Martha Lizett; Ruiz, Jesus A.

    2016-01-01

    Atendiendo al interés de conocer la manera en que se han manejado en Colombia las políticas sobre Seguridad y Defensa Nacional, respecto de la seguridad jurídica de los miembros de la Fuerza Pública, el presente artículo bajo el método bibliográfico e histórico, plantea en su primera parte, la manera en que los gobiernos elegidos a partir de la Constitución de 1991, concibieron la Seguridad y la Defensa, así como sus políticas sobre este particular; posteriormente, se estudian las normas sobr...

  1. VISUALIZACIÓN DE LA MITOSIS CON EL MICROSCOPIO DE FUERZA ATÓMICA

    María de Lourdes Segura-Valdez

    2008-01-01

    Full Text Available En eucariontes, la división celular generalmente ocurre por medio de la mitosis. En estudios previos hemos documentado la posibilidad de estudiar la estructura celular in situ con el microscopio de fuerza atómica, con énfasis en la estructura nuclear en interfase. En este trabajo mostramos que las diferentes etapas de la mitosis pueden ser visualizadas con este instrumento, lo que abre la posibilidad de estudiar este fenómeno en el rango nanométrico.

  2. Aproximación al diseño de un cuantificador de entrenamiento de fuerza

    Torres Fernández, Francisco

    2014-01-01

    En el ámbito de la actividad física, cada vez es más común el uso de gadgets para cuantificar el entrenamiento que realizamos. De esta manera, el usuario dispone de datos de distancia, velocidad, calorías quemadas… lo que le supone un mayor conocimiento sobre la calidad del entrenamiento que ha realizado. Pero si nos fijamos en el mercado de este tipo de gadgets solo miden entrenamiento cardiovascular sin haber aún ninguno que cuantifique un entrenamiento de fuerza, el cual sería de gran util...

  3. Main: 1M2Q [RPSD[Archive

    Full Text Available 1M2Q トウモロコシ Corn Zea mays L. Casein Kinase Ii, Alpha Chain Name=Ack2; Zea Mays Mole...cule: Casein Kinase Ii, Alpha Chain; Chain: A; Fragment: Catlytic Subunit; Synonym: Ckii; Engineered: Yes Tr...ansferase 2.7.1.37 (Casein Kinase Ii, Alpha Chain) E.De Moliner, S.Sarno, S.Moro, G.Zagotto, G.Zanotti, L.A....=2-326.|PDB; 1M2Q; X-ray; A=2-328.|PDB; 1M2R; X-ray; A=2-328.|PDB; 1OM1; X-ray; A=1-332.|Mai

  4. La Infantería de Marina, una fuerza para el siglo XXI

    González Muñoz, Francisco

    2002-10-01

    Full Text Available Not available

    Nuestra Infantería de Marina es la más antigua del mundo. Sus orígenes se remontan al Tercio de Ñapóles de 1537, y desde entonces sus fuerzas han mantenido su tradición naval y expedicionaria con una permanente vinculación a la Armada. Tras una referencia histórica a las diferentes campañas en que ha participado la Infantería de Marina, el que fue su Comandante General durante los últimos cuatro años nos introduce en las vicisitudes y proceso de evolución de este Cuerpo como componente esencial de la Fuerza Anfibia de la Flota, destacando su versatilidad y capacidad de respuesta a las exigencias de hoy día para actuar como vanguardia de la proyección del poder naval en los nuevos escenarios estratégicos que se nos presentan. El artículo es una excelente síntesis para quien desee conocer qué.esy cómo opera la Infantería de Marina, cuáles son sus capacidades, medios, organización y estructura, y cómo está adaptándose para afrontar los desafíos del futuro a medio plazo.

  5. Fuerzas Armadas y transición democrática. Argentina, 1983-1989

    Andrés Alberto Masi Rius

    2009-12-01

    Full Text Available El presente trabajo procura analizar el grado de influencia que las instituciones militares tuvieron en la apertura democrática argentina en 1983. Se analizará la modalidad en que las Fuerzas Armadas influyeron en los discursos en la campaña electoral, las medidas implementadas por la Administración Alfonsín en materia militar, los desequilibrios internos del Ejército Argentino, la disposición (o no de las Fuerzas de subordinarse al poder civil y el rol que las mismas desempeñaron en los levantamientos de 1987 y 1989, líneas que permitirán una adecuado análisis de los aciertos y fragilidades de las estrategias de gobierno en la esfera castrense.______________________ABSTRACT:The research has the purpose of analyzing the influence of the Army institutions during the return to the argentinian democratic system in 1983. It tries to study the way in which the Army influenced in the speeches of the electoral campaign, the political decisions put in practice by the Alfonsin Administration in military order, the Argentinian Forces imbalances, the disposition (or not of subordinating to the civil power and their role during the mutinies between 1987 and 1989, ideas that will allow an adequate analysis of the abilities and fragilities of the government strategies in the military sphere.

  6. LAS FUERZAS ARMADAS EN ESPAÑA: ¿ÚLTIMO BASTIÓN DEL FRANQUISMO?

    Rafael C. Martínez Martínez

    2011-01-01

    Full Text Available Las complicadas relaciones civiles-militares en España tienen como elemento subyacente los duros años de dictadura franquista. En esa tesitura, preguntarse si las fuerzas armadas españolas han culminado su consolidación democrática y han dejado de ser poder político, para convertirse en administración militar resulta pertinente. El presente trabajo sustentado mediante datos de opinión pública y datos extraídos de diversos entrevistas y cuestionarios realizados a los futuros mandos de las fuerzas armadas españolas, devela qué progresos, intensos, se han realizado en ese sentido y qué déficits quedan todavía por solventar, concluyendo en el innegable talante democrático y asunción de la supremacía civil por parte de la oficialidad y suboficialidad más joven del ejército (Tierra, Armada y Aire Español.

  7. ENVEJECIMIENTO, MASA MUSCULAR Y ENTRENAMIENTO DE LA FUERZA: UNA REVISIÓN

    Santiago Adolfo Arboleda Franco

    2014-11-01

    Full Text Available En este artículo se revisan los fundamentos sobre los cuales se ha reconocido la fuerza como elemento esencial en las prescripciones de ejercicio físico para la salud, específicamente en las personas mayores. Se describen las implicaciones de la sarcopenia como síndrome propio de este periodo vital y los hallazgos sobre la importancia de la masa muscular en el equilibrio homeostático mediante su función endocrina. También se examina lo propuesto desde consensos y declaraciones de asociaciones científicas sobre el entrenamiento de distintas manifestaciones de la fuerza en un contexto de salud y se revisa lo hallado en algunos meta–análisis y revisiones sistemáticas recientes sobre los efectos de este entrenamiento en distintas variables relacionadas con la capacidad funcional. Por último, se señalan algunos horizontes de investigación en el tema.

  8. Nonperturbative determination of the QCD potential at O(1/m)

    Koma, Y.; Koma, M.; Wittig, H.

    2006-07-01

    The relativistic correction to the QCD static inter-quark potential at O(1/m) is investigated nonperturbatively for the first time by using lattice Monte Carlo QCD simulations. The correction is found to be comparable with the Coulombic term of the static potential when applied to charmonium, and amounts to 26% of the Coulombic term for bottomonium. (Orig.)

  9. Sample Scripts for Illumina 1M-Duo [

    Full Text Available load_data.txt 4. Importing the result of typing data of the illumina 1M-Duo This script helps you to create ...the result table of all typing data. Example of script: create_table_tbl_fr_recluster.sql CREATE TABLE `tbl_

  10. MEDICION IN VITRO DE LA FUERZA DE FRICCIÓN EN DUPLAS ARCO-BRACKET CON ANGULACIÓN

    Murillo Mora, Emmanuel

    2012-01-01

    En ortodoncia se utilizan técnicas que buscan un máximo control sobre el movimiento de los dientes. Uno de los múltiples factores a considerar en la selección del material, es optar uno que genere menor fuerza friccional.(23). La reducción de la fricción es una de las metas para la nueva generación de bracket. Se investigó la fuerza friccional de 3 tipos de bracket de diferentes marcas comerciales siendo uno de autoligado (Smart Clip) y los otros con eslastomero, en este cas...

  11. Respuesta Sísmica de un puente en Arco considerando la Fluctuación de la fuerza Axial

    Chávez Aguirre, Hidalgo

    2011-01-01

    Los puentes en arco son estructuras que exhiben un comportamiento muy constante, ya que por un lado trabajan de una manera muy eficiente ante cargas permanentes y por el otro presentan un desempeño complejo ante la ocurrencia de temblores fuertes. El arco es un elemento con ductibilidad limitada debido a las elevadas fuerzas de compresión generadas por la carga permanente; además, dichas fuerzas pueden variar de manera importante durante la ocurrencia de un movimiento sísmico. Por lo anterio...

  12. Análisis de las Fuerzas Absolutas y las Circunferencias de Volumen Durante el Período Preparatorio.

    Francisco Freyre Vázquez

    2003-01-01

    Full Text Available Se aborda la relación de dependencia entre los resultados de las fuerzas absolutas de los planos musculares brazo, tronco y pierna, en correspondencia con las circunferencias máximas de volumen de los miembros superiores e inferiores durante la preparación de fuerza a que fueron sometidos los atletas de baloncesto de la categoría juvenil durante el periodo preparatorio. De esta forma estaríamos hablando de la estrecha relación que existe en cuanto a esta variable, repercutiendo en los resultados a alcanzar por el equipo durante el proceso de entrenamiento.

  13. Aportaciones sobre la eficacia del método Pilates en la fuerza, el equilibrio y el riesgo de caídas de personas mayores

    D. Reche-Orenes

    2016-06-01

    Conclusiones: El método Pilates es eficaz para mejorar la fuerza isométrica de cadera y el equilibrio en personas mayores, reduciendo el riesgo de caídas. No existen evidencias suficientes para determinar si la fuerza del core tiene que ver con el equilibrio y las caídas.

  14. Observation of electron temperature profile in HL-1M tokamak

    Cao Jianyong; Xu Deming; Ding Xuantong

    2000-01-01

    The principle and method of the electron temperature measurement by means of electron cyclotron emission (ECE) have been described. Several results under different conditions on HL-1M tokamak have been given. The hollow profile of electron temperature appears in some stages, such as current rising, pellet injection and impurity concentration in the plasma centre. When the bias voltage is applied, the electron temperature profile become steeper. All of the phenomena are related with the transport in plasma centre

  15. Pascua Militar: las órdenes del Rey a las Fuerzas Armadas

    Miguel Ballenilla y García de Gamarra

    2015-06-01

    Full Text Available La Pascua Militar constituye un so-lemne acto castrense presidido por S.M. el Rey al que asisten la Familia Real y las primeras autoridades del Estado. Por su carácter marca-damente institucional, el discurso del Rey es el más relevante de los que se dirigen a las Fuer-zas Armadas. En este trabajo se analiza la evo-lución del citado discurso en las últimas cuatro décadas, los elementos que centran su conteni-do, su relación con el papel que ejerce el Rey como Jefe Supremo de las Fuerzas Armadas, y los acontecimientos que afectan a los Ejércitos y la Defensa Nacional.Palabras clave: Discurso, Análisis, Pascua Mili-tar, Rey, Fuerzas Armadas, Constitución, Transi-ción, Terrorismo._______________ 800x600 Normal 0 21 false false false ES X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} The “Pascua Militar” is a solemn mili-tary ceremony presided by HM The King at-tended by the Royal Family and the highest authorities of the state. The importance of this institutional event becomes the King’s speech as the most relevant of which are addressed to the Armed Forces. In this paper we analyse the evolution of that discourse in the last four dec-ades, we identify the elements that focus their content, it relationship to the role played by the King as Supreme Commander of the Armed Forces and the events affecting them and Na-tional Defence.Keywords: Speech, Analysis, King, Armed Forc-es, Constitution, Political change, Terrorism. Normal 0 21 false false false ES X-NONE X-NONE MicrosoftInternetExplorer4

  16. Programa de instrucción y entrenamiento búsqueda y rescate para la Fuerza Aérea Colombiana

    Javier Eduardo Losada Sierra; Edgar Sánchez Canosa; José Antonio Polo Quesada

    2006-01-01

    Esta investigación tuvo como finalidad elaborar un programa de instrucción y entrenamiento para misiones de búsqueda y rescate, teniendo en cuenta que la Fuerza Aérea Colombiana cumple diariamente operaciones aéreas en todo el territorio nacional que implican riesgos para las tripulaciones y pasajeros de las aeronaves.

  17. Globalizacion, seguridad y crisis. El papel de las fuerzas armadas en el siglo XXI

    Federico Aznar Fernández-Montesinos

    2015-06-01

    Full Text Available El siglo XXI es el siglo de la interconexión y la complejidad. Todo se encuentra interrelacionado, lo que ha obligado a incluir la Defensa en el marco de la Seguridad con el propósito de dar respuestas a los retos que plantea y que ya no son solo militares sino de toda índole, incluidas crisis y catástrofes. Las fuerzas Armadas pueden contribuir con gran eficacia a la hora de atender tales retos. La tendencia no es ya al conflicto entre naciones, sino a la defensa de la Seguridad Nacional e Internacional, lo que genera un enorme cambio en los medios, preparación y doctrina.

  18. Agenda de derechos en Uruguay. Acontecimiento, biopolítica, inmunidad y fuerza de ley

    Sebastián Aguiar Antía

    2018-03-01

    Full Text Available La aprobación entre 2013 y 2014 y la posterior implementación en Uruguay de un conjunto de iniciativas novedosas (regulación de la marihuana, legalización del aborto, matrimonio igualitario y otras presenta varias aristas interesantes desde una perspectiva "biopolítica": la procedencia de estos cambios legislativos, finalmente "acontecimental", una ola de protestas; el carácter crucial y ambivalente de las relaciones de edad detrás de esta nueva agenda; la entrada en la escena de la gubernamentalidad y la regulación de la vida; los procedimientos de inmunización que mantienen nuevos límites tras la incorporación. Finalmente, se muestra la existencia de un cierto estado de excepción, donde fuerzas diferenciales disputan el ejercicio de la ley tras su aprobación legislativa.

  19. Posición de garante de los miembros de la Fuerza Pública

    Jaime Vargas García

    2006-01-01

    Full Text Available En los medios de comunicación de Colombia aparecen continuas informaciones relacionadas con la ocurrencia de hechos de violencia en nuestro país que principalmente afectan a la población civil por la acción de grupos al margen de la ley, por los cuales se viene atribuyendo responsabilidad al Estado y consecuencias penales y disciplinarias por comisión por omisión contra miembros de la Fuerza Pública. Todo parte de “la posición de garante” de las Fuerzas Militares en relación con la defensa nacional y de la Policía sobre la seguridad nacional que obliga a todos sus miembros a proteger la vida y los demás derechos fundamentales relacionados con este de todos los residentes en Colombia. Precisamente el artículo 25 de la Ley 522 de 1999 se encarga de regular la posición de garante en Colombia y el tema adquiere mayor importancia cuando se trata de juzgar conductas de miembros de la Fuerza Pública debido a que la imputación de la omisión se origina precisamente en la delimitación de los ámbitos de competencia de estas instituciones. Sin embargo, la experiencia del conflicto armado nos indica que no existen fronteras perfectamente delimitadas entre las funciones de defensa y seguridad nacional y en el caso de la misma omisión impropia y la posición de garante hay posiciones doctrinales divergentes que no ofrecen ninguna seguridad al asunto y que dificultan la aplicación de esta figura tal como lo reseñamos a lo largo del trabajo y como los destacan importantes autores nacionales y extranjeros. Todo lo anterior viene afectando el desarrollo de las causas penales y a ello se suman las deficiencias del sistema judicial de Colombia particularmente el cuestionamiento nacional e internacional de la jurisdicción penal militar y las sanciones adoptadas por la Corte Interamericana de Derechos Humanos contra el Estado Colombiano. Así mismo, el “concepto de relación con el servicio” del artículo 221 de la carta Política nos parece

  20. Fabrication of 1m x 1m readout strips panel and quality verification of new set of SFS dielectric material

    Kumar, A.; Pandey, A.; Sogarwal, Hariom; Marimuthu, N.; Singh, V.; Subrahmanyam, V.S.

    2016-01-01

    India based Neutrino Observatory (INO) is going to use ∼ 30,000 Resistive Plate Chamber (RPC) as an active detector. Resistive Plate chambers are parallel plate fast gaseous detector made up of high resistivity (10"1"2 ohm) of glass or bakelite. Glass plates work as electrodes of positive and negative potential. When a charged particle passes through chamber it ionizes the gas and charge move towards opposite electrodes. The pick-up panels pick these signals. Signals are sent to front end electronics. The characteristic impedance of the strips of the panels should be matched with front end electronics which helps in minimizing the reflected signal. Since INO is an underground laboratory, all material used in it must be fireproof. Since ∼ 60,000 pick-up panels are going to be used in INO hence it should be cheaper also. We recently received a new set of Silicon Fiber Sheets - a dielectric material, of 25 pieces of 1m x 0.5m having thickness 05 mm. We fabricated a set of readout strips panel of dimension 1m x 1m. We will present this work in detail

  1. RELACIÓN ENTRE DIFERENTES PRUEBAS DE CAMPO: FUERZA, POTENCIA Y VELOCIDAD

    Jessenia Hernández Elizondo

    2003-12-01

    Full Text Available Esta investigación tuvo como propósito principal el encontrar por medio de pruebas en las variables de fuerza, potencia y velocidad, la relación matemática existente entre estos tres constructos. Participaron 56 sujetos varones con edades entre 18 y 25 años. Con el fin de responder al objetivo del estudio, se les aplicaron pruebas de campo de fuerza (1RM de sentadilla completa y repeticiones máximas al 80% 60% 40% y 20%, de velocidad (30 metros lanzados y 30 metros sin impulso, y de potencia (salto vertical con contra-movimiento SVCM, salto vertical sin impulso SVSI y salto vertical con caída SVCC, para correlacionar las diferentes pruebas entre sí. Los datos fueron analizados por medio de la correlación de Pearson (r, para correlacionar parejas de pruebas y correlación canónica (Rc para correlacionar grupos de variables. A partir de cada correlación se obtuvo la varianza explicada (r2 la cual indica el porcentaje de relación compartida en escala de 0-100 que existe entre las pruebas. Según los datos obtenidos, no existe relación significativa (2.1% entre las pruebas de salto-sentadilla, ni relación significativa (5.1% entre las pruebas de velocidad- sentadilla, mientras que la relación salto- velocidad (62%, fue estadísticamente significativa (p < 0.05. La implicación de estos resultados podrían respaldar la idea de que la relación teórica que existe entre estos constructos, no es completamente cierta cuando éstos son medidos por medio de pruebas de campo.

  2. Las fuerzas armadas en América Latina, antes y hoy

    Dirk Kruijt

    2012-07-01

    Full Text Available Se esboza en la primera parte del presente artículo el legado político de las fuerzas armadas: intromisión en el sistema político, golpes y dictaduras militares, pero también el hecho de que exmilitares son generalmente exitosos en elecciones democráticas. En un segundo momento se analiza tanto la ideología como las características de los “ejércitos políticos” en las décadas pasadas: el monopolio sobre el “patriotismo nacional”, traducido en doctrinas de seguridad nacional y el dominio sobre la inteligencia nacional y las fuerzas de la policía, la ejecución de programas cívico-militares de desarrollo local en zonas remotas y la inmunidad de facto con cierta base legal. Luego se presenta una tipología durante la transición hacia la democracia: tutelaje militar, control manso e impunidad. El análisis sigue con el desarrollo de otra tipología de militares y soldados en el poder bajo el régimen democrático electoral: caudillos militares transformados en demócratas y exguerrilleros como presidentes elegidos. Es seguido por dos formas recientes de sucesión presidencial por mecanismos no electorales: la expulsión de presidentes por revueltas populares y algunos (intentos de golpes. Luego se presenta un análisis de nuevas agendas de seguridad y nuevas misiones militares durante la primera década del presente siglo. Se enfatiza explícitamente la actuación militar en el contexto de la lucha (“guerra” contra el crimen organizado, la guerra contra la droga y los efectos sobre la seguridad interna.

  3. Effect of recycling in the HL-1M tokamak

    Zheng Yongzhen

    2004-01-01

    Tokamak plasma discharge disruption at high density is investigated. The instability analysis on model indicates that the disruption is resulted from the energy loss arising from hydrogen recycling on the edge of the plasma. This energy loss could lead to a contraction of the current channel and the production of a disruptively unstable configuration. Using a simple model we shall investigate the implications of recycling for disruptions. The critical high-density n≤1.6 x 10 20 m -3 is reached in HL-1M. (author)

  4. Note: A 1-m Foucault pendulum rolling on a ball

    Salva, H. R.; Benavides, R. E.; Venturino, J. A.; Cuscueta, D. J.; Ghilarducci, A. A.

    2013-10-01

    We have built a short Foucault pendulum of 1-m length. The aim of this work was to increase the sensitivity to elliptical trajectories from other longer pendula. The design was a semi-rigid pendulum that rolls over a small ball. The measurements of the movements (azimuth and elliptical trajectory) were done by an optical method. The resulting pendulum works in a medium satisfactory way due to problems of the correct choice of the mass of the bob together with the diameter of the supporting ball. It is also important to keep the rolling surface very clean.

  5. Investigation on HL-1M pellet shape and cloud structure

    Zheng Yinjia

    2001-01-01

    When hydrogen multi-pellet flied out from the gun exit and was injected into the HL-1M plasma, the pellet injection and ablation cloud were observed by using a 2D CCD camera SensiCam 360LF. The shape of flight pellet from the gun exit was obtained with the photos taken. The pellet ablation process and the structure of its cloud were analyzed by means of photos with multiple exposure (exp. 100 ns) and long exposure. The experimental setup is described, the results of the pellet injection experiment and characteristic of ablation cloud are presented

  6. Evaluación de la fuerza explosiva de extensión de las extremidades inferiores en escolares

    Francisco José López Gallego

    2016-01-01

    Full Text Available Objetivo. El objetivo de esta investigación es evaluar la capacidad de fuerza explosiva de extensión de extremidades inferiores en escolares de educación primaria y analizar las diferencias que puedan existir tanto en capacidad de fuerza explosiva de extremidades inferiores como en composición corporal en función del sexo. Material y métodos. En este estudio han participado 90 estudiantes (54 niños y 36 niñas de educación primaria de un centro educativo urbano de la provincia de Jaén. La media de la edad de los sujetos es de 11,1 ± 0,7 años. Se ha realizado la valoración de la composición corporal y la evaluación de la capacidad de fuerza explosiva de extremidades inferiores mediante salto vertical. La evaluación de la composición corporal se llevó a cabo mediante la plataforma INBODY 230 (Microkaya, Spain. Para medir las variables de los saltos se utiliz ó una plataforma de fuerzas Quattro Jump (Kistler, Suiza y se realizaron los test de salto CMJ y ABK. Resultados y conclusiones. Los resultados obtenidos en las variables de los test de salto por los participantes se encuentran entre los valores de referencia para sujetos de su edad. Las chicas poseen mayores picos de potencia y de fuerza que los chicos, mientras que estos poseen mayores alturas de vuelo en los saltos. En la impedancia los chicos obtienen mayores porcentajes de músculo y las chicas mayor masa y mayores porcentajes de grasa.

  7. Development of high field superconducting Tokamak 'TRIAM-1M'

    Ito, Satoshi; Suzuki, Takao; Suzuki, Shohei; Nishi, Masatsugu; Kawasaki, Takahide.

    1984-01-01

    The tokamak nuclear fusion apparatus ''TRIAM-1M'' which is constructed in the Research Institute for Applied Mechanics, Kyushu University, has a number of distinctive features as compared with other tokamak projects, that is, the toroidal field coils are made of superconductors for the first time in Japan, and the apparatus is small and has strong magnetic field. Hitachi Ltd. designed and has forwarded the manufacture of the TRIAM-1M. In this paper, the total constitution of the apparatus and the design and manufacture of the plasma vacuum vessel, superconducting toroidal coils and others are reported. The objectives of research are the containment of strong field tokamak plasma and the establishment of the law of proportion, the development of turbulent flow heating method, the adoption of mixed wave current driving method and the practical use of Nb 3 Sn superconducting coils. The apparatus is composed of the vacuum vessel containing plasma, toroidal field coils, poloidal field coils, current transformer coils and turbulent flow heating coils for plasma heating, heat insulating vacuum vessel and supporting structures. The evacuating facility, helium liquefying refrigerator and cooling water facility are installed around the main body. (Kako, I.)

  8. Characterization of an in-vacuum PILATUS 1M detector.

    Wernecke, Jan; Gollwitzer, Christian; Müller, Peter; Krumrey, Michael

    2014-05-01

    A dedicated in-vacuum X-ray detector based on the hybrid pixel PILATUS 1M detector has been installed at the four-crystal monochromator beamline of the PTB at the electron storage ring BESSY II in Berlin, Germany. Owing to its windowless operation, the detector can be used in the entire photon energy range of the beamline from 10 keV down to 1.75 keV for small-angle X-ray scattering (SAXS) experiments and anomalous SAXS at absorption edges of light elements. The radiometric and geometric properties of the detector such as quantum efficiency, pixel pitch and module alignment have been determined with low uncertainties. The first grazing-incidence SAXS results demonstrate the superior resolution in momentum transfer achievable at low photon energies.

  9. Thai Research Reactor (TRR-1/M1) Neutron Beam Measurements

    Ratanatongchai, Wichian

    2009-07-01

    Full text: Neutron beam tube of neutron radiography facility at Thai Research Reactor (TRR-1/M1) Thailand Institute of Nuclear Technology (public organization) is a divergent beam. The rectangular open-end of the beam tube is 16 cm x 17 cm while the inner-end is closed to the reactor core. The neutron beam size was measured using 20 cm x 40 cm neutron imaging plate. The measurement at the position 100 cm from the end of the collimator has shown that the beam size was 18.2 cm x 19.0 cm. Gamma ray in neutron the beam was also measured by the identical position using industrial X ray film. The area of gamma ray was 27.8 cm x 31.1 cm with the highest intensity found to be along the neutron beam circumference

  10. Transport barrier formation by LHCD on TRIAM-1M

    Hanada, K.; Iyomasa, A.; Zushi, H.; Hasegawa, M.; Nakamura, K.; Sakamoto, M.; Sato, K.N.; Idei, H.; Kawasaki, S.; Nakashima, H.; Higashijima, A.; Sasaki, K.; Hoshika, H.

    2004-01-01

    Internal transport barrier (ITB) has been obtained in full lower hybrid current driven (LHCD) plasmas on a superconducting tokamak, TRIMA-1M (R 0.84 m, a x b = 0.12 m x 0.18 m, B T L/R . ITB is terminated by the reduction of current drive efficiency caused by metal impurities accumulation. In some condition, self organized slow sawtooth oscillations (SSSO) of plasma current, density, temperature, and so on with the period comparable to the current diffusion time have been also observed during ITB discharge. The oscillation has the capability of particle exhaust, as the result, it may play an role in the avoidance of the impurity accumulation and the dilution in the future steady state fusion plasma with ITB, as the edge-localized mode in H-mode. (authors)

  11. The observation of dust behavior in TRIAM-1M

    Sasaki, K.; Hanada, K.; Nishino, N.; Tokitani, M.; Yoshida, N.; Sato, K.N.; Zushi, H.; Nakamura, K.; Sakamoto, M.; Idei, H.; Hasegawa, M.; Kawasaki, S.; Nakasihma, H.; Higashijima, A.

    2007-01-01

    The observation of dusts in plasmas was carried out by high speed camera in full non-inductive lower hybrid current drive (LHCD) plasma on TRIAM-1M. The velocities of dusts were 10-50 m/s. The number of dust generated per second increased with the discharge duration in the range of 20-57 s. This suggests that a part of dusts were generated from a movable limiter whose the surface temperature increases with the discharge duration. Dusts were coming from various directions even close to the movable limiter. Dusts were collected in the vacuum vessel by use of a kind of cleaner and the composition and the size of dust were examined by Scanning Electron Microscope (SEM). Dust size was several μm and composition was Molybdenum mixed with small amount of elements of stainless metal. The poloidal distribution of the collected mass of dusts was almost uniform

  12. B-meson spectroscopy in HQET at order 1/m

    Bernardoni, Fabio; Fritsch, Patrick; Univ. Autonoma de Madrid; Gerardin, Antoine; Univ. Blaise Pascal CNRS/IN2P3, Aubiere; Heitger, Jochen; Hippel, Georg von; Simma, Hubert

    2015-05-01

    We present a study of the B spectrum performed in the framework of Heavy Quark Effective Theory expanded to next-to-leading order in 1/m b and non-perturbative in the strong coupling. Our analyses have been performed on N f =2 lattice gauge field ensembles corresponding to three different lattice spacings and a wide range of pion masses. We obtain the B s -meson mass and hyperfine splittings of the B- and B s -mesons that are in good agreement with the experimental values and examine the mass difference m B s -m B as a further cross-check of our previous estimate of the b-quark mass. We also report on the mass splitting between the first excited state and the ground state in the B and B s systems.

  13. Reaching 1 m deep on Mars: the Icebreaker drill.

    Zacny, K; Paulsen, G; McKay, C P; Glass, B; Davé, A; Davila, A F; Marinova, M; Mellerowicz, B; Heldmann, J; Stoker, C; Cabrol, N; Hedlund, M; Craft, J

    2013-12-01

    The future exploration of Mars will require access to the subsurface, along with acquisition of samples for scientific analysis and ground-truthing of water ice and mineral reserves for in situ resource utilization. The Icebreaker drill is an integral part of the Icebreaker mission concept to search for life in ice-rich regions on Mars. Since the mission targets Mars Special Regions as defined by the Committee on Space Research (COSPAR), the drill has to meet the appropriate cleanliness standards as requested by NASA's Planetary Protection Office. In addition, the Icebreaker mission carries life-detection instruments; and in turn, the drill and sample delivery system have to meet stringent contamination requirements to prevent false positives. This paper reports on the development and testing of the Icebreaker drill, a 1 m class rotary-percussive drill and triple redundant sample delivery system. The drill acquires subsurface samples in short, approximately 10 cm bites, which makes the sampling system robust and prevents thawing and phase changes in the target materials. Autonomous drilling, sample acquisition, and sample transfer have been successfully demonstrated in Mars analog environments in the Arctic and the Antarctic Dry Valleys, as well as in a Mars environmental chamber. In all environments, the drill has been shown to perform at the "1-1-100-100" level; that is, it drilled to 1 m depth in approximately 1 hour with less than 100 N weight on bit and approximately 100 W of power. The drilled substrate varied and included pure ice, ice-rich regolith with and without rocks and with and without 2% perchlorate, and whole rocks. The drill is currently at a Technology Readiness Level (TRL) of 5. The next-generation Icebreaker drill weighs 10 kg, which is representative of the flightlike model at TRL 5/6.

  14. El trabajo de fuerza en el desarrollo de la potencia en futbolistas de las divisiones menores de un equipo profesional de fútbol Strength training in the development of power in soccer players of the inferior divisions of Deportivo Independiente Medellin (DIM, in Colombia

    Carlos Adolfo Castro Castro

    2007-04-01

    immediate muscular power: speed in 20 m, Squat Jump and Countermovement Jump. Results: although the 60 players completed the training, data were analyzed for only 29 in the experimental group and 27 in the control one; of the remaining 4 participants, 2 left the team and 2 suffered injuries unrelated with the training. No significant differences were found between the two groups, in any of the variables, in any of the 3 measurements. Most of the variables -strength of the right knee extensors, strength of the left knee extensors, strength of the right knee flexors, strength of the left knee flexors, Squat Jump, Countermovement Jump – had statistically significant increases (p < 0.05 in each group both at 6 weeks and between weeks 6 and 12, the only exception being the speed in 20 m that presented significant increase only at six weeks. For both groups, the r Pearson´s correlation between maximum strength of right knee extensors, SJ and CMJ ranged from moderate to high and were statistically significant (p < 0.05 at the beginning of the study as well as at 6 and 12 weeks of the maximum strength training; correlation with the speed in 20 m was found only at the beginning of the work. Conclusions: maximum strength training at intensities of 75 and 85% of 1-M produces significant improvement in immediate muscular power.

  15. Fuerza pública, negociaciones de paz y posacuerdo en Colombia, de E. Cruz Rodríguez

    Roland Marcelo Franco Grisales

    2017-01-01

    Full Text Available En este texto, el politólogo de la Universidad Nacional de Colombia y magíster en Análisis de Problemas Políticos, Económicos e Internacionales Contemporáneos, Edwin Cruz Rodríguez, presenta una reflexión inicial acerca de la función de la fuerza pública colombiana (FP —compuesta por los cuerpos de Ejército y Policía Nacional— en un posible escenario de posacuerdo, de cara a los diálogos de paz que se desarrollaron en La Habana, Cuba, entre el Gobierno nacional de Colombia y las Fuerzas Armadas Revolucionarias de Colombia (FARC-EP.

  16. Ejercicios de fuerza, glucocorticoides y composición corporal en pacientes diabéticos de la tercera edad

    Yolanda Cedeño Almaguer

    2010-01-01

    Full Text Available Se presentaron los resultados obtenidos a través de un cuasi- experimento que reveló los efectos del entrenamiento de fuerza sobre la composición corporal de pacientes diabéticos de la tercera edad, sometidos a tratamientos con glucocorticoides. La muestra estuvo constituida por 13 pacientes (8 mujeres y 5 hombres los cuales comenzaron, por prescripción médica, tratamiento con glucocorticoides. Por medio de mediciones antropométricas se determinaron indicadores de adiposidad y masa muscular en tres ocasiones, entre las que se incluye la etapa después de aplicado un programa de entrenamiento de 12 semanas sobre la base de ejercicios de fuerza.

  17. Programa de evaluación continua de riesgos para la aeronavegabilidad en la Fuerza Aérea Colombiana (CARE

    Ana Isabel Aguilar González

    2010-01-01

    Igualmente, busca proponer la implementación de acciones efectivas que mitiguen su influencia negativa, mediante la optimización de los procesos de gestión organizacional empleados en el mantenimiento aeronáutico, esperando que se constituya en un aporte valioso para poder conocer la condición actual de la aeronavegabilidad y sus efectos en la seguridad operacional dentro de la Fuerza Aérea Colombiana.

  18. La fuerza vinculante de la jurisprudencia en el orden jurídico colombiano

    Carlos Bernal Pulido

    2003-12-01

    Full Text Available El carácter de la fuente formal y material del derecho que hoy tiene la jurisprudencia no es una innovación de la Constitución Política de 1991. El artículo propone una definición operativa de fuerza vinculante, muestra cómo los elementos de esa definición se verifican en la jurisprudencia y cuál es el sentido constitucionalmente adecuado que se ha de otorgar entonces a la expresión “criterio auxiliar” en el artículo 230 de la Constitución. La argumentación hace ver por qué el trabajo de aplicación judicial del derecho lleva consigo la creación judicial de normas jurídicas contenidas en la parte motiva de las sentencias. Tales normas, que deberían llamarse adscritas, resultan vinculantes para las altas cortes de manera sui generis. Es necesario diseñar un procedimiento de control de la sujeción de los jueces ordinarios a la jurisprudencia constitucional, que también formule de manera explícita las reglas a las que haya de atenerse la Corte Constitucional.

  19. Terminología de los ejercicios de fuerza con sobrecargas (I

    Francesc Cos Morera

    2016-01-01

    Full Text Available Las ciencias aplicadas a la actividad física y el deporte son relativamente recientes y deben de estandarizar todavía su vocabulario en algunas áreas de conocimiento. Establecer una terminología de consenso y unívoca en relación a los ejercicios de fuerza es fundamental para los profesionales que trabajan en las ciencias del ejercicio físico y el cuerpo humano. Es imprescindible articular una terminología unívoca en este sector de intervención social de gran repercusión. El derecho a la libre circulación de personas por los países de la Unión Europea y, en general, la globalización, hace necesario también el conocimiento de la terminología de la musculación en otras lenguas vehiculares. El siguiente artículo es el primero de una serie de cuatro y presenta los ejercicios más representativos de pecho y hombro en versiones castellana, catalana e inglesa, con el objetivo que conformen una base de gran alcance que permita definir otros ejercicios.

  20. Terminología de los ejercicios de fuerza con sobrecargas (y IV

    Francesc Cos Morera

    2011-12-01

    Full Text Available Las ciencias aplicadas a la actividad física y el deporte son relativamente recientes y deben estandarizar todavía su vocabulario en algunas áreas de conocimiento. Establecer una terminología de consenso y unívoca en relación con los ejercicios de fuerza con sobrecargas es fundamental para los profesionales que trabajan en las ciencias del ejercicio físico y el cuerpo humano. Es imprescindible articular una terminología vehicular en este sector de intervención social de gran repercusión. El derecho a la libre circulación de personas por los países de la Unión Europea y, en general, la globalización, hace necesario también el conocimiento de la terminología de la musculación en otras lenguas vehiculares. El siguiente artículo es el último de una serie de cuatro y presenta los ejercicios más representativos de extremidad inferior como, abductores, aductores, extensores y flexores de la cadera, extensores y flexores de la rodilla, flexores del pie y levantamientos olímpicos, en versiones castellana, catalana e inglesa, con el objetivo de que conformen una base de gran alcance que permita definir otros ejercicios

  1. Terminología de los ejercicios de fuerza con sobrecargas (III

    Francesc Cos Morera

    2009-11-01

    Full Text Available Las ciencias aplicadas a la actividad física y el deporte son relativamente recientes y deben estandarizar todavía su vocabulario en algunas áreas de conocimiento. Establecer una terminología de consenso y unívoca en relación con los ejercicios de fuerza es fundamental para los profesionales que trabajan en las ciencias del ejercicio físico y el cuerpo humano. Es imprescindible articular una terminología vehicular en este sector de intervención social de gran repercusión. El derecho a la libre circulación de personas por los países de la Unión Europea y, en general, la globalización, hace necesario también el conocimiento de la terminología de la musculación en otras lenguas vehiculares. El siguiente artículo es el tercero de una serie de cuatro y presenta los ejercicios más representativos de espalda, abdominales y estabilizadores, en versiones castellana, catalana e inglesa, con el objetivo de que conformen una base de gran alcance que permita definir otros ejercicios.

  2. Terminología de los ejercicios de fuerza con sobrecargas (II

    Francesc Cos Morera

    2011-06-01

    Full Text Available Las ciencias aplicadas a la actividad física y el deporte son relativamente recientes y deben estandarizar todavía su vocabulario en algunas áreas de conocimiento. Establecer una terminología de consenso y unívoca en relación con los ejercicios de fuerza es fundamental para los profesionales que trabajan en las ciencias del ejercicio físico y el cuerpo humano. Es imprescindible articular una terminología unívoca en este sector de intervención social de gran repercusión. El derecho a la libre circulación de personas por los países de la Unión Europea y, en general, la globalización, hace necesario también el conocimiento de la terminología de la musculación en otras lenguas vehiculares. El siguiente artículo es el segundo de una serie de cuatro y presenta los ejercicios más representativos de rotadores internos y externos del hombro, elevadores del hombro, flexores del codo, extensores del codo y flexores y extensores de la muñeca en versiones castellana, catalana e inglesa, con el objetivo de que conformen una base de gran alcance que permita definir otros ejercicios.

  3. Aplicación de un sistema para calcular déficit de fuerza resistencia en atletas de fondo

    Eduardo Valcarce Merayo

    2012-12-01

    Full Text Available Con este estudio se pretende determinar la evolución en la longitud de zancada en atletas de resistencia que no periodizan el entrenamiento de fuerza. En el estudio participaron 6 sujetos varones atletas de resistencia de 31 años (± 4,6 años, con una experiencia deportiva de 14 años (± 4 años que realizaron un entrenamiento interválico donde se determinó la velocidad, frecuencia y amplitud de zancada media de cada repetición a partir de la zona de grabación. El porcentaje de pérdida de amplitud de zancada, medido a través del índice SLS (stride loss strength comparó dicha pérdida de longitud de zancada (cm/m ∙ s–1 entre grupos de repeticiones: Grupo 1 (repeticiones 1-7, Grupo 2 (repeticiones 8-14, Grupo 3 (repeticiones 15-21 observándose un descenso significativo en el índice SLS entre Grupo 2 y el Grupo 3 (p = 0,05. Concluyendo que este indicador es una herramienta específica para determinar posibles déficits de fuerza en este tipo de deportistas, ayudando a entrenadores y atletas que quieran evaluar los niveles de fuerza resistencia en una medición de campo.

  4. EFECTO DE UN PROGRAMA DE EJERCICIOS CON PESAS EN EL PORCENTAJE DE GRASA Y LA FUERZA EN MUJERES MAYORES

    Magally Márquez Barquero

    2001-12-01

    Full Text Available El propósito del estudio fue determinar los efectos crónicos del entrenamiento con pesas sobre el porcentaje de grasa y la fuerza. Los participantes, de sexo femenino, entrenadas (n=10, edad 54.6 ± 4.19 años, un peso inicial promedio de 66.08 ± 12.50 Kg y una talla promedio de 1.585 ±0.0754 m., fueron divididos aleatoriamente en dos grupos: 50% de 5RM (n=5, 80% de 5 RM (n=5 y un pre test de registro de línea base. Las variables medidas fueron fuerza y porcentaje de grasa. Ambos grupos realizaron dos sesiones por semana durante doce semanas. Los ejercicios para ambos grupos fueron press de banca horizontal, extensión de rodilla, flexión de rodilla y jalón de polea frontal. El volumen de ejercicio total por sesión fue de 2550 unidades para el grupo que trabajo al 50 % (3 series x 17 rep. X 50% y 2560 para el que trabajo al 80% (4 series x 8 repeticiones x 80%. La fuerza se midió con el Test de 5 RM y el porcentaje de grasa fue estimado con la técnica de toma de siete pliegues cutáneos con el calibrador manual de piel marca Lange y subsecuentemente estimado usando la ecuación Leger y Cloutier para mujeres mayores de 50 años. Resultados: Para las pruebas de fuerza, press de banca, flexión de rodilla y extensión de rodilla hubo mejora significativa, tanto para el grupo que se ejercitó al 50 % como al 80 % de intensidad (p<0.05. Mientras que para la prueba halón de polea al frente el cambio entre mediciones (p<0.05, siendo mayor para el grupo que se ejercitó al 80 % de intensidad. En cuanto al porcentaje de grasa, disminuyó (p<0.05 similarmente a ambas intensidades de ejercicio. En conclusión, a intensidades del 50% como del 80% de 5RM, disminuye el porcentaje de grasa y aumenta la fuerza, en mujeres con una edad comprendida entre los 50 y 59 anos quienes realizaron una misma carga total de ejercicio con pesas. Los hallazgos sugieren que el entrenamiento con pesas a cargas altas, beneficia a los grandes grupos musculares.

  5. La fuerza del espíritu (fe en el camino (ancestral indígena

    Paola Andrea Pérez Gil

    2016-01-01

    Full Text Available El mundo de hoy se encuentra encerrado en la visión reduccionista y enajenada que ha sido imperante a lo largo de la historia, el valor del consumo, la ambición y el individualismo han enterrado los valores fundantes de sencillez, humildad y honestidad. La profunda necesidad de volver la mirada al conocimiento y psicología propios, ha hecho que retornemos a la sabiduría de las plantas, los abuelos, lugares sagrados, costumbres y mitos para abandonar la ilusión racionalista que todo lo divide, todo lo niega y nada lo contempla. El camino recorrido en el fuego, la montaña, Sie, el chunsúa, las cansamarias, permite mirar, recordar y recuperar lo fundamental en la existencia humana: su propia fuerza, la fe. Esa que sostiene la vida, que va más allá de verificación o comprobación alguna, que es cultivada en la palabra dulce, el tejido sentido y la esencia misma. Conectando al humano en sus diferentes niveles, a su psiquismo, conectándolo al amor. Por ello, la importancia de vivenciar a Sue, Chía, en y con la Hytcha Guaia, vivenciar al Espíritu en su expresión más latente, aceptar al ego como uno de los maestros para comprender el ser, integrar la materia y lo trascendente, entregarse a la ley de los abuelos, a lo sagrado propio, a la conciencia profunda, al guerrero interno, a la vida misma.

  6. Micro satellite instability in colorectal cancer stage II. Hospital Central de las fuerzas armadas

    Della Valle, A; Santander G; Camejo, N; Spera, G.

    2010-01-01

    Introduction: micro satellite instability (MSI) is a good prognostic factor in colorectal cancer (CRC) located. Its value as a predictive marker against adjuvant treatment of chemotherapy (CT) has been shown fluoropyrimidine in various publications. The MSI occurs in 15% of colorectal tumors and sporadic in 90% of tumors in the context of colorectal cancer syndrome hereditary nonpolyposis. In Uruguay there are no studies about this phenomenon. Objective: To determine the incidence of micro satellite instability in a sample of patients using the Hospital Central de las fuerzas armadas oncology service, association with a compatible family history and the histological features of the tumors associated therewith. Methods: The medical records of patients were analyzed with CRC diagnosed stage II between 01/2001 and 12/2009. Data of the patients were analyzed which had complete histology and evolution. Results: 30/52 patients (57.6%) were analyzed. 40% had a detected MSI by kits for Pcr (polymerase chain reaction) to D2S123, D5S250, D17S346, BAT25 and BAT26 according to the Bethesda criteria. In those patients they filed a MSI: the median age was 70 years; 58.3% male. No patient had a family history consistent with HNPCC. 5.6% (3) they received Adjuvant chemotherapy treatment. Regarding tumor characteristics: 75% (9) were T3, and T4 were 25% (3); 8.3% histologic grade I (1) II 58.3% (7) 8.3% III (1) without Data 33% (6). This tumor lymphocyte infiltration was reported in 25% (3), absent 33.3% (4), not reported in 41.6% (5). Conclusions: This is the first analysis of these characteristics carried out in Uruguay. The same has been detected MSI percentage higher than reported in the literature International. In either case a compatible family history met HNPCC

  7. Fuerza de trabajo femenina en la agricultura de exportación de brócoli en Cotopaxi

    Yumbla Mantilla, María Rosa

    2015-01-01

    En la provincia de Cotopaxi, el cultivo de brócoli se extiende principalmente en las parroquias de Guaytacama cantón Latacunga y en la parroquia Pujilí cantón Pujilí, territorios en los cuales al conformarse este agronegocio se genera una oferta y demanda de fuerza de trabajo espe- cialmente femenina, que bajo el estereotipo de ‘cualidades femeninas’ de docilidad y precisión son contratadas para cumplir altas normas de calidad exigidas por mercados internacionales. Se analiza las característi...

  8. ANÁLISIS DEL POTENCIAL COMPETITIVO DEL BIOETANOL EN COLOMBIA: UN ENFOQUE DESDE LAS 5 FUERZAS COMPETITIVAS DE MICHAEL PORTER

    RAMIREZ VELASQUEZ ALEJANDRO; MONTOYA R. IVÁN ALONSO; MONTOYA RESTREPO ALEXANDRA

    2012-01-01

    La búsqueda de alternativas de producción y consumo energético requiere una mirada hacia la industria de los combustibles biológicos como el bioetanol que, como alternativa energética, permita superar los inconvenientes generados por los métodos tradicionales de producción y consumo, en especial en los temas políticos, ambientales y sociales y generar ventajas competitivas frente a otras fuentes primarias de energía. En el presente documento,a partir del modelo de las cinco (5) Fuerzas de Mic...

  9. Factores determinantes del rendimiento en el ejercicio de dominadas y efectos del entrenamiento concurrente de fuerza y resistencia

    Sánchez Moreno, Miguel

    2017-01-01

    Programa de Doctorado en Actividad Física, Rendimiento Deportivo y Salud En la presente Tesis Doctoral se abordan una serie de problemáticas relacionadas, por una parte, con la mejora del entendimiento sobre aquellos factores que pueden ser determinante para el rendimiento en el ejercicio de dominadas y por otra parte, sobre cuestiones relacionadas con la influencia que puede tener la realización de dos grados de esfuerzo durante el entrenamiento de fuerza del miembro inferior sobre el re...

  10. Determination of the constants of the solubility product of Ln(OH){sub 3} and the effect of the chloride ions on the lanthanum hydrolysis, praseodymium and lutetium in aqueous solutions of ion force 2 Molar; Determinacion de las constantes del producto de solubilidad de Ln(OH){sub 3} y el efecto de los iones cloruro sobre la hidrolisis de lantano, praseodimio y lutecio en soluciones acuosas de fuerza ionica 2 Molar

    Lopez G, H.D

    2005-07-01

    The behavior of lanthanum (III), praseodymium (III), and lutetium (III) was studied in 2 M NaClO{sub 4} (aq) and 2 M NaCl (aq) at 303 K and free -CO{sub 2} conditions. Solubility diagrams (p Ln(aq)-pC{sub H}) were obtained by means of a radiochemical method. The pC{sub H} borderlines of saturation and unsaturation zones of the solutions and solubility product constants for Ln(OH){sub 3} were determined from these diagrams. The fitting of the solubility equation to the experimental values of p Ln(aq)-pC{sub H} diagrams allowed the calculation of the first hydrolysis and solubility product constants. Independently, the stability constants for the first species of hydrolysis were determined by means of pH titrations, the data were treated with the program SUPERQUAD and fitted to the mean ligand number equation. The stability constants for the species LnCl{sup 2+} were as well calculated in 2M ionic strength and 303 K from the hydrolysis constant values obtained in both perchlorate and chloride media. The values obtained for La, Pr and Lu were: logK{sub ps}: 21.11 {+-} 0.09, 19.81 {+-} 0.11 and 18.10 {+-} 0.13 in 2M NaClO{sub 4}; logK{sub ps}: 22.22 {+-} 0.09, 21.45 {+-} 0.14 and 18.52 {+-} 0.29 in 2M NaCl; log {beta}{sub 1}: - 8.64 {+-} 0.02, - 8.37 {+-} 0.01 and - 7.95 {+-} 0.11 in 2M NaClO{sub 4}; log {beta}{sub 1}{sup /} : - 9.02 {+-} 0.11, - 8.75 {+-} 0.01 and - 8.12 {+-} 0.03 in 2M NaCl and the values for log {beta}{sub 1,Cl} were - 0.0255, - 0.155 and - 0.758, respectively. (Author)

  11. Fuerzas producidas en un punto dentro de la masa del suelo debidas al peso del suelo y a las presiones del agua

    Félix Hernández Rodríguez

    1991-09-01

    Full Text Available Buena parte de la labor del ingeniero de suelos radica en la evaluación de las reacciones en ciertos puntos de la masa de suelo. Esas reacciones, esfuerzo efectivo normal y esfuerzo portante, son el producto de las fuerzas de cuerpo que afectan los puntos en cuestión. Se presentan en el artículo los dos métodos de evaluación de esas reacciones: el método del peso unitario total y de las fuerzas periféricas del agua y el método del peso unitario sumergido y la fuerza de infiltración.

  12. ANÁLISIS DEL POTENCIAL COMPETITIVO DEL BIOETANOL EN COLOMBIA: UN ENFOQUE DESDE LAS 5 FUERZAS COMPETITIVAS DE MICHAEL PORTER

    RAMIREZ VELASQUEZ ALEJANDRO

    2012-11-01

    Full Text Available La búsqueda de alternativas de producción y consumo energético requiere una mirada hacia la industria de los combustibles biológicos como el bioetanol que, como alternativa energética, permita superar los inconvenientes generados por los métodos tradicionales de producción y consumo, en especial en los temas políticos, ambientales y sociales y generar ventajas competitivas frente a otras fuentes primarias de energía. En el presente documento,a partir del modelo de las cinco (5 Fuerzas de Michael Porter, se realiza una evaluación de la industria del bioetanol como combustible alternativo y se expone qué tan atractiva o competitiva puede llegar a ser su industria en la actualidad. Para lograr este propósito, se propone una evaluación de las fuerzas competitivas a un panel de expertos, usando escalas deLikert, para encontrar el potencial de la propuesta.

  13. Revisión del alcance de los conceptos eficacia contractual, fuerza vinculante y relatividad de los contratos

    Joaquín Quiró Saldaña

    2014-07-01

    Full Text Available Los institutos jurídicos tienen la particularidad de no ser inmutables, sino que, sus definiciones, y respectivos alcances, varían con el devenir del tiempo. Dichos cambios muchas veces obedecen al dictado de nuevas normas y otras, igualmente importantes, a la evolución de la ciencia jurídica y de la jurisprudencia las que, mediante la interpretación y sistematización de los preceptos jurídicos, le otorgan a los mismos sentidos muchas veces ni siquiera "soñados" por sus autores. Tomando como referencia este segundo punto de vista afrontamos el presente trabajo acerca de la eficacia de los contratos, su fuerza vinculante y la relatividad de los derechos emergentes del mismo con la intención de conferirles una dimensión diferente a la dada hasta el momento.Contenido: Introducción. El contrato como fuente de derecho objetivo. Ubicación del contrato en el sistema jurídico. Límites formales: análisis de los distintos escalones del ordenamiento jurídico. Límites materiales: determinación y clasificación. Eficacia contractual. Fuerza vinculante. Relatividad. Conclusiones

  14. ¿INSERCIÓN LABORAL DE LAS MUJERES EN AMÉRICA LATINA: UNA FUERZA DE TRABAJO SECUNDARIA?

    Laís Abramo

    2004-01-01

    Full Text Available http://dx.doi.org/10.1590/S0104-026X2004000200013 El objetivo principal de este texto es discutir la aplicación de la noción de “fuerza de trabajo secundaria” para caracterizar la fuerza da trabajo femenina en América Latina. Esa caracterización, hecha con frecuencia en forma mecánica por un lado corresponde, cada vez menos a la realidad de los hechos, ya que es creciente la participación femenina en el mercado de trabajo, así como la continuidad de sus trayectorias laborales, el número de horas dedicadas al trabajo remunerado, así como su aporte al ingreso familiar y a la superación de la situación de pobreza de un porcentaje importante de hogares. Por otro lado, el texto argumenta que esa caracterización es uno de los elementos centrales en la estructuración de los patrones de discriminación de género que persisten y se reproducen en el mercado de trabajo latinoamericano.

  15. Efectos a Corto Plazo en Variables Cardiorrespiratorias de 2 Programas de Entrenamiento de Fuerza Prescribiendo Intensidad de Ejercicio con la RPE

    José Luis Maté Muñoz

    2015-01-01

    Full Text Available El objetivo del estudio fue calcular las variables cardiorrespiratorias comparando un programa de entrenamiento de fuerza tradicional en condiciones estables con otro programa de fuerza en condiciones inestables, prescribiendo la carga de entrenamiento a partir de la escala de percepción subjetiva del esfuerzo. Se llevó a cabo un diseño aleatorio con grupo control asignando 36 hombres sanos a dos grupos experimentales (n = 24 y a un grupo control (n = 12, realizando dos entrenamientos de fuerza en circuito (ejercicios de fuerza con pesos libres y máquinas de musculación y ejercicios en BOSU® y TRX®. Los programas de fuerza duraron 7 semanas (3 sesiones por semana, midiendo las variables cardiorrespiratorias en un test de esfuerzo incremental pre y post entrenamiento. Para los valores de umbral ventilatorio 1, los resultados indicaron una reducción significativa de la frecuencia cardíaca después del período de entrenamiento tanto en el factor Tiempo (F = 12,777; p < 0,01 como en la Interacción (F = 4,718; p = 0,016, sin encontrar significación estadística entre los tres grupos (F = 1,279; p = 0,293. También se redujo significativamente el consumo de oxígeno a primer umbral, siendo esta disminución más acentuada en el grupo tradicional (F = 5,401; p = 0,027. Por tanto, se concluye que los valores de las variables cardiorrespiratorias después de 7 semanas de entrenamiento de fuerza en diferentes condiciones (estabilidad e inestabilidad y, prescribiendo las cargas de entrenamiento a través de la RPE, son similares.

  16. Experiencias en el desarrollo de una aplicación robótica con control de fuerza para taladrado de huesos

    J.C. Fraile

    2008-04-01

    Full Text Available Resumen: En los sistemas de cirugía ortopédica asistida por ordenador (CAOS, el taladrado del hueso en la reparación de fracturas de huesos largos (para estabilizarlos con placas, clavos o tornillos es una tarea compleja que el cirujano debe realizar con gran precisión, evitando el calentamiento excesivo del tejido óseo. En la cirugía asistida por robots, se han utilizado principalmente robots industriales (Robodoc, Caspar, Crigos adaptados a ambientes quirúrgicos para ayudar al cirujano en esta tarea. En esta tarea de taladrado de huesos es necesario tener en cuenta varios factores: temperatura del hueso, velocidades de giro y avance de la herramienta de taladrado y fuerzas y pares que actúan sobre el hueso durante su taladrado.Es fundamental el desarrollo de algoritmos de control del robot manipulador para garantizar que las distintas variables que intervienen en el proceso de taladrado tomen los valores adecuados, bajo el control del cirujano, y así lograr una mayor calidad y precisión en la tarea quirúrgica de taladrado del hueso.Desafortunadamente, la mayoría de los robots industriales tienen una arquitectura de control propietaria que impide una fácil implantación de algoritmos de control externos basados en realimentación multisensorial (visión, fuerza.En este artículo se presenta el diseño de una arquitectura de control distribuido y abierto, que se ha implantado sobre el controlador de un robot Staubli. En ella se ha desarrollado una estrategia de control basada en realimentación de fuerza, que permite al cirujano realizar la tarea quirúrgica de taladrado del hueso con elevada precisión. Durante el taladrado con el robot, las fuerzas y pares que actúan sobre el hueso son medidos y utilizados para controlar la velocidad de avance de la herramienta de taladrado, y para controlar la fuerza aplicada al hueso. Se han obtenido resultados experimentales en condiciones de laboratorio con el manipulador equipado con un

  17. Métodos de entrenamiento de la fuerza para la mejora de las acciones en el fútbol [Strength Training Methods for Improving Actions in Football

    Raya González, Javier; Sánchez Sánchez, Javier

    2018-01-01

    Debido a las características específicas del fútbol, donde las acciones de alta intensidad como saltos y cambios de dirección pueden llegar a ser factores determinantes para conseguir el éxito deportivo, incluir el entrenamiento de fuerza en las planificaciones de entrenamiento en fútbol se hace imprescindible. En función de las variables sobre las que se quiera incidir y del momento de la temporada, se deberá elegir un método de entrenamiento de la fuerza concreto, por lo que el conocimiento...

  18. Valoración de la intensidad del entrenamiento de fuerza a través de la velocidad en el aula

    Sarabia, José Manuel; Hernández-Davó, Jose Luis; Javaloyes Torres, Alejandro; López-Grueso, Raúl; Sabido, Rafael

    2017-01-01

    El entrenamiento de fuerza ha recabado gran interés por la literatura científica en los últimos años, dada su importancia en campos tan dispares como el rendimiento deportivo, la calidad de vida en la tercera edad, o la mejora de patologías que se reflejan en la incapacidad funcional de los pacientes. Desde el punto de vista de la valoración y la planificación del entrenamiento de fuerza son distintas las variables claves que lo definen, ocupando especial relevancia la intensidad de dicho ent...

  19. Evolución de la pérdida de peso en dos personas sometidas a un programa de entrenamiento de fuerza con distintos ejercicios

    Giménez Romo, Javier

    2014-01-01

    Objetivos: Evaluar la eficacia que tiene un entrenamiento de fuerza “tradicional”(ET)y un entrenamiento de fuerza con ejercicios más globales (EG) en dos personas distintas con obesidad para observar cuál de ellos es más efectivo tanto para la pérdida de grasa corporal como para la mejora del estado de forma. Y comparar el gasto energético que tienen estos dos tipos de entrenamiento. Conclusiones: Los resultados de este trabajo muestran que tanto un ET como un EG podrían ser efectivos par...

  20. Efectos de diferentes métodos de entramiento de fuerza y resistencia de agarre en escaladores deportivos de distintos niveles

    López Rivera, Eva María

    2016-01-01

    Introducción:Hasta el momento la metodología y planificación de entrenamiento utilizada por los escaladores ha estado basada en la observación, intuición y en el ensayo-error. Numerosos estudios sugieren que la fuerza y resistencia de dedos es un factor de rendimiento en la escalada deportiva. Sin embargo, no hemos encontrado ningún trabajo que haya comparado y valorado los efectos de diferentes métodos de entrenamiento específico de fuerza y resistencia de dedos. El control de la carga es un...

  1. Efectos de un entrenamiento personalizado basado en la musculación sobre los niveles de fuerza y composición corporal de un sujeto activo

    Paz Moraga, Francisco

    2014-01-01

    En el trabajo se realiza un repaso de los diferentes tipos de planificación, programación y periodización en el entrenamiento de fuerza, así como las diferentes metodologías existentes para el desarrollo de la misma en sujetos con experiencia en el entrenamiento con cargas. También se analizan los diferentes tipos de medición de la fuerza máxima y la composición corporal del sujeto durante el programa de entrenamiento. El objetivo fue conseguir un incremento de los niveles de f...

  2. Correlación entre los resultados de valoración funcional y de fuerza de la rodilla en pacientes con rotura del ligamento cruzado anterior

    Álvarez Santana, David

    2016-01-01

    Programa de doctorado: Avances en Traumatología. Medicina del Deporte. Cuidado de Heridas. La fecha de publicación es la fecha de lectura [ES]Objetivos: Determinar si existen diferencias en la fuerza isométrica en la rodilla afecta con respecto a la sana en pacientes con rotura de LCA y un grupo control. Estudiar si existe correlación significativa entre el desplazamiento tibial, la fuerza isométrica generada por la musculatura de las rodillas, los resultados en cuestionarios de valoración...

  3. Efectos del HIIT en la composición corporal, potencia máxima y fuerza máxima : un estudio preexperimental

    Jiménez Rodríguez, Francisco Miguel

    2013-01-01

    El principal objetivo de este estudio es conocer los efectos del HIIT en la composición corporal, fuerza dinámica (FDM) y potencia máxima (Pmáx) de miembro superior e inferior, potencia en saltos y fuerza máxima isométrica (FIM) manual. Cuatro hombres activos universitarios de similares características (21.5 ± 0.5 años, 175.75 ± 2.63 cm, 76.27 ± 4.76 kg) se ofrecieron como voluntarios para formar parte del estudio, un estudio preexperimental, sin grupo control, en el que realizaron un protoco...

  4. Nucleolin Mediates MicroRNA-directed CSF-1 mRNA Deadenylation but Increases Translation of CSF-1 mRNA*

    Woo, Ho-Hyung; Baker, Terri; Laszlo, Csaba; Chambers, Setsuko K.

    2013-01-01

    CSF-1 mRNA 3′UTR contains multiple unique motifs, including a common microRNA (miRNA) target in close proximity to a noncanonical G-quadruplex and AU-rich elements (AREs). Using a luciferase reporter system fused to CSF-1 mRNA 3′UTR, disruption of the miRNA target region, G-quadruplex, and AREs together dramatically increased reporter RNA levels, suggesting important roles for these cis-acting regulatory elements in the down-regulation of CSF-1 mRNA. We find that nucleolin, which binds both G-quadruplex and AREs, enhances deadenylation of CSF-1 mRNA, promoting CSF-1 mRNA decay, while having the capacity to increase translation of CSF-1 mRNA. Through interaction with the CSF-1 3′UTR miRNA common target, we find that miR-130a and miR-301a inhibit CSF-1 expression by enhancing mRNA decay. Silencing of nucleolin prevents the miRNA-directed mRNA decay, indicating a requirement for nucleolin in miRNA activity on CSF-1 mRNA. Downstream effects followed by miR-130a and miR-301a inhibition of directed cellular motility of ovarian cancer cells were found to be dependent on nucleolin. The paradoxical effects of nucleolin on miRNA-directed CSF-1 mRNA deadenylation and on translational activation were explored further. The nucleolin protein contains four acidic stretches, four RNA recognition motifs (RRMs), and nine RGG repeats. All three domains in nucleolin regulate CSF-1 mRNA and protein levels. RRMs increase CSF-1 mRNA, whereas the acidic and RGG domains decrease CSF-1 protein levels. This suggests that nucleolin has the capacity to differentially regulate both CSF-1 RNA and protein levels. Our finding that nucleolin interacts with Ago2 indirectly via RNA and with poly(A)-binding protein C (PABPC) directly suggests a nucleolin-Ago2-PABPC complex formation on mRNA. This complex is in keeping with our suggestion that nucleolin may work with PABPC as a double-edged sword on both mRNA deadenylation and translational activation. Our findings underscore the complexity of

  5. Determination of forces induced by steam flow in turbines; Determinacion de fuerzas inducidas por flujo de vapor en turbinas

    Garcia Castrejon, Juan Carlos

    2008-09-15

    rotor, lo que lleva a fracturas de los componentes por fatiga. Este trabajo estudia y calcula las fuerzas de excitacion de las vibraciones inducidas por flujo. Se realiza el analisis del flujo, en dos etapas diafragma-rotor de una turbina de vapor, con base en el Modelado Computacional de Dinamica de Fluidos (MCDF). Las etapas de la turbina bajo estudio son la primera etapa o paso Curtis y la ultima etapa o etapa de baja presion de la Turbina. El paso Curtis esta formado por alabes pequenos y el flujo esta sometido a altas presiones. El ultimo paso esta compuesto por alabes grandes y el flujo esta sometido a bajas presiones. El MCDF resuelve numericamente las ecuaciones que representan la dinamica de fluidos y se obtiene la variacion del campo de presion en el claro axial rotor-estator causada por la interaccion de las estelas del borde de salida de los diafragmas con el movimiento de los alabes. La variacion del campo de presion induce fuerzas en los alabes ocasionando vibraciones forzadas. En cada una de las etapas se realizaron simulaciones en 2D y 3D, que se resolvieron en funcion del tiempo, usando el modelo de turbulencia RNG - y la tecnica de malla deslizante, para simular el movimiento de los alabes. Los modelos en 3D se resolvieron usando computo en paralelo en un cluster compuesto por 6 procesadores AMD Optaron e 64 bits, 2412.36 MHz y 8Gb de memoria RAM. Los resultados de las simulaciones en las dos etapas, permitieron obtener el comportamiento del campo de presion en el claro axial tobera-rotor y las fuerzas que este campo induce sobre los alabes. La fuerza sobre los alabes fue calculada usando un codigo que se ejecutaba en cada paso temporal de la simulacion, esta fuerza fue posteriormente analizada usando la transformada rapida de Fourier para obtener la fuerza sobre los alabes como una expresion matematica. Usar el MCDF para obtener las fuerzas que actuan sobre los alabes y que son inducidas por flujo representa una ventaja sobre otros metodos de calculo

  6. Relación entre potencia máxima, fuerza máxima, salto vertical y sprint de 30 metros en atletas cuatrocentistas de alto rendimiento

    Carlos Balsalobre-Fernández

    2012-06-01

    Full Text Available Mediante un diseño ex post facto y valiéndose de una muestra de catorce atletas cuatrocentistas de alto rendimiento, entre los que se encuentran diferentes medallistas nacionales del Estado Español, este estudio hace tres aportaciones: la primera, describe la fuerza de extremidades inferiores de este colectivo y su capacidad de aceleración en 30 metros; la segunda, informa de la relación de covariación entre, por una parte, la variable potencia y, por otra, la fuerza máxima, la fuerza explosiva y la capacidad de aceleración, encontrándose correlaciones significativas con valores entre 0,60 y 0,81; y la tercera, se demuestra que la potencia máxima de estos deportistas se encuentra entre el 50 % y el 70 % de su Repetición Máxima en media sentadilla. Asimismo, se discuten los resultados y se argumenta que el entrenamiento de la fuerza es una condición necesaria para mejorar el rendimiento deportivo de alto nivel, postulando que los datos sobre potencia máxima encontrados en este estudio ayudarán a técnicos y deportistas a planificar sus cargas óptimas de entrenamiento.

  7. Fuerza muscular, flexibilidad y postura en la prevalencia de dolor lumbar de los tripulantes de helicópteros del Ejército Nacional de Colombia

    Imma Caicedo Molina

    2013-10-01

    Full Text Available Objetivo. Determinar la relación entre la fuerza muscular, la flexibilidad y la postura con la prevalencia de dolor lumbar en los tripulantes de helicópteros del Ejército Nacional de Colombia. Materiales y métodos. Se realizó un estudio de tipo transversal bajo un modelo de regresión logística múltiple, enfocado en la medición de la fuerza muscular, la flexibilidad y la postura en tripulantes de helicópteros del Ejército Nacional de Colombia. Resultados. 108 tripulantes fueron evaluados, de quienes el 59,3 % presentó dolor lumbar. Se encontró que la fuerza de los músculos extensores de tronco constituyó un factor de protección (OR= 0,98. p0,05 y OR=1,04, p<0,05, Chi cuadrado 2,80 respectivamente. Conclusión. La fuerza muscular adecuada de los extensores de tronco constituye un factor protector frente al dolor lumbar en los tripulantes de helicópteros. Sin embargo, es necesario desarrollar más investigaciones en esta población que permitan mayor comprensión de los factores relacionados con el dolor. Las variables intervinientes de contexto, junto con las variables fisiocinéticas, constituyen una red compleja de determinantes del dolor lumbar en los tripulantes de helicópteros.

  8. EFECTO DE UN ESTÍMULO AGUDO DE HIPOXIA SOBRE LA VELOCIDAD DE MOVIMIENTO EN UN EJERCICIO DE FUERZA DEL TREN SUPERIOR

    Ismael Martínez-Guardado

    2015-04-01

    Full Text Available En general, el entrenamiento de fuerza tiene un potente efecto para incrementar el tamaño y la fuerza del músculo esquelético (Kraeme, Fleck & Evans, 1995. El uso de un estímulo de hipoxia durante el entrenamiento comenzó a desarrollarse a través de técnicas de restricción del flujo sanguíneo (Takarada et al., 2000. Un estímulo similar lo podemos llevar a cabo mediante el uso de cámaras de hipoxia y a través de sistemas de entrenamiento intermitente (Lundby, Calbet, Robach, 2009. La adicción de este estímulo hipóxico al entrenamiento podría incrementar la hipertrofia muscular y la ganancia de fuerza.Objetivo: Analizar los efectos de un entrenamiento de fuerza del tren superior en condiciones de hipoxia sobre el número de repeticiones y la velocidad del movimiento.

  9. Fuerza Aérea Colombiana: El cuadro de mando integral, orientación para su aplicación en la institución

    Andrés Velásquez

    2006-07-01

    Full Text Available Caso de aplicación del Cuadro de Mando Integral para que los gerentes de las empresas colombianas conozcan sus bondades y establezcan un contraste con una aplicación en una organización altamente jerárquica como la Fuerza Aérea Colombiana

  10. Efecto de 24 sesiones de entrenamiento de fuerza en un paciente con gonartrosis bilateral: a propósito de un caso

    O. Abrahin

    2015-03-01

    Conclusión: Los resultados de este estudio indican que 24 sesiones de EF progresivo pueden ser eficaces en la mejora de índices antropométricos, la capacidad funcional y la fuerza muscular de un paciente anciano diagnosticado de GA bilateral.

  11. Espacio y honra en “La fuerza de la sangre” y “El celoso extremeño”.

    Daniel R. Walker.

    2009-01-01

    Full Text Available Resumen: En las Novelas ejemplares, Cervantes cuestiona algunos de los paradigmas sociales más centrales del Siglo de Oro español, subvirtiendo sus premisas y haciendo visibles los esqueletos de su construcción. Este proceso de divulgación tiene el fin de hacer patentes los mecanismos complicados de un concepto tan intrínsicamente encerrado en la conciencia colectiva de la época como el de la honra. Mientras que en sus obras el dramaturgo Lope de Vega opta por reforzar los cimientos de este concepto por medio de la puesta en escena de una ideología conservadora que sutura casi perfectamente las cicatrices de su práctica, Cervantes, en cambio, no intenta ocultar la base de sus raíces. Es sobre todo en La fuerza de la sangre y El celoso extremeño donde se muestra la artificialidad misma del concepto por su curiosa espacialización. Es decir, dentro de estas novelas, la honra opera según su ubicación espacial y sus connotaciones cambian dependiendo del espacio de los acontecimientos de los relatos. Esta fragmentación de un concepto supuestamente unido y totalizador lo desestabiliza y deja la noción de la honra completamente subvertida. Mientras que La fuerza de la sangre demuestra una marcada diferencia entre la honra pública y la honra privada a través de la meticulosa construcción de los varios entornos del relato, El celoso extremeño pone de relieve que en realidad el único espacio de la honra es el de la imaginación. La inestabilidad y el carácter efímero de la honra llegan a ser el centro de las ficciones, cuestionando así la ideología dominante estabilizadora que generalmente tenía la honra como uno de sus epicentros más fuertes.Summary: In his Novelas ejemplares, Cervantes questions some of the most important social paradigms of the Spanish Golden Age, subverting their premises and making visible the framework of their construction. In the end, this process of revelation sheds much light on the complicated

  12. La gestión en seguridad aérea en la Fuerza Aérea Colombiana

    Eduardo Behar Benítez

    2006-01-01

    Full Text Available La reestructuración de la Fuerza Aérea Colombiana obedece a una decisión estratégica establecida bajo el principio institucional de disposición al cambio, el cual se define como un estado mental que permite abrir el entendimiento de manera amplia para escuchar y evaluar a conciencia y sin prejuicios, nuevas propuestas para adaptar los comportamientos a las circunstancias de un mundo en permanente cambio e incertidumbre, cada vez más apoyado en la tecnología y telecomunicaciones que trascienden las barreras geográficas tradicionales.

  13. Efectos de un programa de flexibilidad en el desarrollo de la fuerza muscular en jugadoras de futbol

    José E. Del Río Valdivia

    2015-12-01

    Full Text Available Se analizó el impacto de un programa de entrenamiento de flexibilidad sobre el desarrollo de la fuerza muscular en 16 jugadores de futbol con edad de 19.03±2.7 años. Se entrenó durante 30 días y 5 veces por semanas, donde el grupo “A” realizó  entrenamiento de flexibilidad, mientras que “B” el entrenamiento regular. Se midió la flexibilidad, 1RM, salto vertical, peso, talla, circunferencia de pantorrilla y muslo. Los resultados muestran  valores para A y B respectivamente, donde el IGF fue de 91.01 ± 18.3 y 111.93 ± 23.5;  78.22 ± 29, y  79.03 ± 29.1. La circunferencia femoral, 48.04 ± 3.6 cms y 49.54 ± 3.4 cms.; 47.56 ± 4.9 y 47.89 ± 5.2. Circunferencia de pantorrilla, 33.83 ± 2.7 cm y 35.21 ± 2.4 cm; 33.83 ± 2 y 33.73 ± 2.8. Fuerza  48.13 ± 7.8 Kg. y 53.38 ± 8.2 Kg.; 52.63 ± 8.6 Kg. y 53.39 ± 9.1 Kg. Potencia anaeróbica, 34.13 ± 2.9 cm. y 36.63 ± 1.7 cm; 38.25 ± 4.7 y 37.06 ± 3.4. Como conclusión se tiene que el  uso la  flexibilidad impacta de forma  positiva en el  IGF y por tanto en el desarrollo favorable muscular de jugadoras de futbol.

  14. Rivas y Verdi: Las trampas de la libertad en La fuerza del sino y La forza del destino

    Egido, Aurora

    2012-06-01

    Full Text Available A comparative analysis between Duque de Rivas’Don Álvaro o la fuerza del sino and La forza del destino by Giuseppe Verdi shows, even in their very titles, the close relationship between Spain and Italy since the days of the Golden Age. Both works posit the old theological problem of compatibility between predestination and free will, while adding new social and political insights into social and racial differences and highlighting the narrowness of the code of honour. Otherwise, as far as the admixture of genres or the treatment of costumbrismo and nationalism are concerned, the difference between both works increases in the second version of Verdi´s opera, in which the alteration of the denouement wipes out the tragical dimension of the spanish play.Un análisis comparativo entre Don Álvaro o la fuerza del sino del duque de Rivas y La forza del destino de Giuseppe Verdi demuestra, ya desde sus títulos, un viaje de y vuelta entre España e Italia que tiene como fondo la literatura del Siglo de Oro. Ambas obras plantean el viejo problema entre providencia y libertad, añadiendo nuevos relieves sociales y políticos sobre las diferencias de clase y raza que ponen en evidencia las estrecheces del código del honor. Las diferencias entre ambas —más allá de la mezcla genérica, el tratamiento costumbrista y el nacionalismo— se acentúan en la segunda versión de la ópera verdiana, que, al cambiar el desenlace, destruyó el sentido trágico del drama español.

  15. Un acercamiento a la fuerza pública en los estados de Cundinamarca y Santander, 1857-1885

    Yaneth Cristina Mendoza Chacón

    2011-01-01

    Full Text Available El presente trabajo tuvo como objetivo producir una representación histórica sobre la estructura, el funcionamiento y las transformaciones de la Fuerza Pública en los Estados de Cundinamarca y Santander, durante el período 1857-1885, mediante el seguimiento de sus aspectos administrativos, así como la evolución, organización, composición y distribución de sus efectivos armados, a través del seguimiento a su forma constitucional o legal. Se presentan las bases constitucionales que sostuvieron al cuerpo militar, y se analiza hasta qué punto lograron cumplirse, de tal forma que se pudo demostrar la doble dinámica en que funcionó el cuerpo armado del Estado, girando entre un carácter militar y sus funciones de control civil del orden público. Al conocerse la evolución del Ejército seccional, se pudieron comprender los resultados que dejó la experiencia federal en las instituciones nacionales, especialmente en la militar, demostrándose una vez más, que la irregularidad del presupuesto y la subordinación del poder militar al civil, generaron las mayores contradicciones del cuerpo armado. Sin embargo, tal experimento sirvió para demostrar cuán necesaria fue la presencia de Fuerza Pública, pues a pesar de los inconvenientes que presentó el período, con sus doctrinas liberales, llevadas al extremo, la institución logró mantenerse, medianamente, hasta el tiempo en que llegó su Reforma Militar.

  16. Vigencia del método de Roth para la determinación de fuerzas de cortocircuito en devanados de transformadores

    Guillermo Andrés Aponte Mayor

    2018-01-01

    Full Text Available Contexto: Debido a la dificultad para realizar la prueba de aptitud al cortocircuito en transformadores de gran potencia, la norma IEC 60076-5 2006 de la Comisión Electrotécnica Internacional acepta como método alternativo la estimación de las fuerzas y esfuerzos a través de cálculo y consideraciones de diseño. Método: En este artículo se presenta la implementación del método analítico de Roth para el cálculo de las fuerzas axiales y radiales de cortocircuito en un transformador trifásico con núcleo tipo columnas de 630kVA. Resultados: Las fuerzas máximas obtenidas con el método de Roth son comparables con las calculadas a través de métodos modernos para el diseño de transformadores como el método de elementos finitos, las diferencias entre los cálculos fueron mínimas a excepción de la fuerza axial máxima del devanado de baja tensión. Conclusiones: Aunque el método de Roth es una herramienta tradicional para solución de problemas de electromagnetismo, este es adecuado para hacer una estimación rápida y sencilla de parámetros magnéticos y fuerzas de cortocircuito en transformadores.

  17. Efectividad de un protocolo de entrenamiento nórdico sobre la fuerza explosiva en futbolistas del Club Deportivo La Equidad Seguros

    Érica Mabel Mancera-Soto

    2016-09-01

    Full Text Available Introducción. El entrenamiento nórdico ha sido estudiado para optimizar el gesto deportivo y prevenir lesiones en fútbol. Sin embargo, no se han reportado estudios que evidencien su efectividad sobre la fuerza explosiva del deporte. Objetivo. Determinar la efectividad de un protocolo de entrenamiento nórdico sobre la fuerza explosiva de miembros inferiores en futbolistas. Materiales y métodos. Se realizó un ensayo controlado y aleatorizado en el que 26 futbolistas masculinos fueron elegidos para hacer parte de un grupo intervención (n=12 y un grupo control (n=14. Al grupo intervención se le aplicó un protocolo de entrenamiento nórdico, mientras que el control realizó un programa de fortalecimiento convencional. Se evaluaron la fuerza explosiva de miembros inferiores, a través del Test de Bosco y Abalakov en una plataforma de salto, y el ángulo de mayor reclutamiento muscular del bíceps femoral durante la ejecución del ejercicio nórdico mediante de electromiografía de superficie. Resultados. Los dos grupos fueron homogéneos. Se evidenció una mejora en los componentes de la fuerza explosiva (p<0.05 para las variables de velocidad de despegue, de reclutamiento motor y de ángulo de registro del pico de reclutamiento motor en el grupo de intervención. Conclusión. La aplicación de un programa de entrenamiento en futbolistas demostró ser efectiva al influir de manera positiva en las variables involucradas en la fuerza explosiva.

  18. Complete Genome Sequence of Methylobacterium populi P-1M, Isolated from Pink-Pigmented Household Biofilm

    Morohoshi, Tomohiro; Ikeda, Tsukasa

    2016-01-01

    Methylobacterium populi P-1M is isolated from the pink-pigmented household biofilm. Here, we present the complete genome sequence of P-1M, consisting of one chromosome of 5,705,640?bp and five plasmids of 64,864?bp, 59,879?bp, 42,569?bp, 41,417?bp, and 29,506?bp.

  19. Electroestimulación neuromuscular intradiálisis, fuerza muscular, capacidad funcional y composición corporal

    Sandra Rubio Páez

    2015-12-01

    Full Text Available Introducción: La capacidad funcional disminuida y la importante atrofia muscular caracterizan a los pacientes en hemodiálisis (HD. El ejercicio físico intradiálisis y recientemente la electroestimulación neuromuscular (EMS, representan dos serias opciones terapéuticas para mejorar esta deteriorada condición física. Actualmente, no existen estudios publicados sobre el papel de la EMS y la composición corporal en los pacientes en HD. Objetivo: Analizar que efecto produce un programa de EMS sobre la fuerza muscular, capacidad funcional, parámetros nutricionales y composición corporal en nuestros pacientes en HD. Material y Métodos: Estudio unicéntrico, prospectivo de 12 semanas de duración. Los pacientes incluidos realizaron un programa adaptativo de EMS en ambos cuádriceps intradiálisis mediante el dispositivo Compex R Theta 500i. Analizamos: 1.- Parámetros nutricionales (Albumina, pre albúmina, triglicéridos, colesterol total y fracciones, ferritina y Proteína C reactiva. 2.- Datos musculares: Composición muscular cuadriceps, Fuerza extensión máxima cuádriceps (FEMQ y handgrip (HG brazo dominante. 3.- Test funcionales: "Sit to stand to sit" (STS10 y "six-minutes walking test" (6MWT. 4.- Composición corporal mediante biompedancia electrica (BIA. Resultados: 13 pacientes incluidos: (69.2% hombres. Edad media: 65.7 años y 33.9 meses en HD. I.Charlson medio 9.1. La principal etiología de la ERC fue la DM (38.5%. Al final del estudio se observó una mejoría en (*p<0.05: FEMQ* (11.7±7.1 vs 13.4±7.4 Kg, STS10 (39.3±15.5 vs 35.8±13.7 seg, 6MWT* (9.9%, 293.2 vs 325.2 m. En relación a la composición corporal, se observó únicamente un aumento significativo del área muscular (AMQ*: 128.6 ± 30.2 vs 144.6 ± 22.4 cm² y una disminución del área grasa (AGQ*: 76.5 ± 26.9 vs 62.1 ± 20.1 cm² a nivel quadricipital, sin cambios en el resto de datos analizados (% grasa abdominal, peso graso, peso magro, agua corporal total

  20. Periodización del entrenamiento de fuerza y resistencia en piragüistas de alto nivel

    Jesús García-Pallarés

    2010-09-01

    Full Text Available Este estudio examinó en un grupo de 18 kayakistas varones de alto nivel (incluidos 11 medallistas de Campeonatos del Mundo o de Europa y dos Campeones Olímpicos los cambios en variables cardiorrespiratorias, neuromusculares, hormonales, composición corporal y de rendimiento durante un ciclo de 12 semanas de entrenamiento concurrente de fuerza y resistencia cardiovascular. Así mismo se analizaron los efectos producidos por un periodo de 4 semanas de puesta a punto (TAP y una fase de desentrenamiento (DTR de 5 semanas en la que la mitad de los palistas cesaron totalmente los estímulos de entrenamiento (CE y la otra mitad realizó únicamente una sesión de entrenamiento de fuerza y dos de resistencia semanales (RE. El volumen y la intensidad de entrenamiento fueron cuantificados a nivel individual durante todas las fases del estudio. El ciclo periodizado de entrenamiento concurrente de 12 semanas produjo aumentos significativos de un 9,5% en el consumo máximo de oxígeno (VO2max y de un 9,4% y en el consumo de oxígeno en el segundo umbral ventilatorio (VO2 VT2. La velocidad de desplazamiento en VO2max, y en VT2 aumentó un 6,2% y un 4,4% respectivamente. Los valores de una repetición máxima (1RM aumentaron un 4,2% en press banca (PB y un 5,3% en dorsal remos (DR, mientras que la velocidad con el 45% del 1RM (V45% aumentó un 14,4% en PB y un 10,0% en DR. Tras la fase de TAP no se observaron cambios significativos en ninguna de las variables estudiadas. Durante la fase de DTR, el grupo de CE mostró mayores descensos del 1RM (–8,9% y –7,8%, para el PB y el DR respectivamente que los observados para el grupo de RT (–3,9% y –3,4%. Los descensos en la V45% en el PB y el DR fueron mayores para el grupo de CE (–12,6% y –10,0% que para el grupo RE (–9,0% y –6,7%. Los descensos en el VO2max fueron menores tras la RE (–5,6% que tras la CE (–11,3%, aunque las pérdidas en VO2 VT2 fueron similares en ambos grupos. La fase de RE

  1. Plataforma productiva como fuerza del desarrollo endógeno del sector de manufacturas plásticas

    Maryana Sandrea

    2014-01-01

    Full Text Available La plataforma productiva de una localidad constituye un soporte a la actividad empresarial, en términos de infraestructura física y servicios conexos, que dependiendo de sus condiciones estimula o frena el desarrollo endógeno. En este contexto, el objetivo general de la investigación consiste en analizar las condiciones de la plataforma productiva como fomento al desarrollo endógeno, en el sector de manufacturas plásticas, utilizando básicamente los aportes de Vázquez (2005 y 2007. El estudio realizado es descriptivo y de campo, con un diseño transversal, no experimental, incluyendo una entrevista a 30 empresas, guiada con un formato estructurado. Entre los resultados destacan: el 56,7% de los entrevistados presentan una posición desfavorable, en cuanto a las condiciones de la plataforma de apoyo al proceso productivo como estímulo al desarrollo del sector en la región, un 63,4% de los consultados afirman que la infraestructura física para el traslado de mercancías no favorecen la actividad del sector. La mayoría (76,7% de los entrevistados consideró que el funcionamiento de los servicios administrativos del gobierno, constituye un soporte valioso a las actividades empresariales, especialmente en cuanto a la posibilidad de realizar trámites vía Internet. Para la mayoría de las empresas consideradas (60%, el desarrollo urbano del territorio se presenta como una fuerza relativamente débil en el entorno productivo. Se concluye, que la relativa debilidad de ésta fuerza en la región, obedece a las deficiencias en las condiciones de la infraestructura económica, en particular al mantenimiento de la red de carreteras secundarias, así como en la prestación del servicio eléctrico, mientras que la infraestructura institucional resultó fortalecida, por tanto, para elevar el grado de desarrollo será necesario realizar intervenciones a fin de mejorar las condiciones de la infraestructura económica.

  2. Ejercicio aeróbico y de fuerza en personas con una enfermedad pulmonar obstructiva (epoc: estudio de caso

    Lara Blas

    2016-12-01

    Full Text Available El objetivo del estudio fue describir las respuestas fisiológicas de pacientes con EPOC en cada una de las sesiones de un programa de entrenamiento físico de ocho semanas y analizar los efectos producidos por el programa en el rendimiento físico de estos pacientes. En este estudio participaron cuatro personas a las que se les diagnosticó EPOC (64±6 años. Se realizó un test (T1 de 6 minutos de caminata (6MWT para determinar la capacidad cardiovascular de los participantes y, después de ocho semanas, se volvió a repetir el mismo test (T2. Durante las ocho semanas se llevó a cabo trabajo de resistencia aeróbica e interválica, de fuerza, estiramientos y trabajo de musculatura respiratoria. No se observó un aumento significativo en las variables fisiológicas (tensión sistólica, tensión diastólica y saturación de oxígeno tras la realización del 6MWT ni en el T1 ni en el T2. Sin embargo, la tensión sistólica, tanto en el Post test del T1 (∆%=24.8±22.1; TE=2.2, alto como en el Post test del T2 (∆%=14.0±13.2; TE=1.0, alto, presentó una tendencia a ser superior con respecto al Pre test, en ambos casos. Por otro lado, los participantes recorrieron ligeramente más metros después de 8 semanas de intervención (∆%=4,61; TE=0.4, bajo, lo cual se acompañó, de una mayor percepción del esfuerzo (∆%=107.1; TE=3.0 y ∆%=200.0; TE=1.8 para RPEmus. Los participantes en este estudio obtuvieron una ligera mejora en el rendimiento físico en el test 6MWT, posiblemente debido a que las sesiones no se enfocaron solamente en la mejora de la capacidad aeróbica, sino también en la mejora de la fuerza muscular.

  3. Plataforma productiva como fuerza del desarrollo endógeno del sector de manufacturas plásticas

    Maryana Sandrea

    2014-01-01

    Full Text Available La plataforma productiva de una localidad constituye un soporte a la actividad empresarial, en términos de infraestructura física y servicios conexos, que dependiendo de sus condiciones estimula o frena el desarrollo endógeno. En este contexto, el objetivo general de la investigación consiste en analizar las condiciones de la plataforma productiva como fomento al desarrollo endógeno, en el sector de manufacturas plásticas, utilizando básicamente los aportes de Vázquez (2005 y 2007. El estudio realizado es descriptivo y de campo, con un diseño transversal, no experimental, incluyendo una entrevista a 30 empresas, guiada con un formato estructurado. Entre los resultados destacan: el 56,7% de los entrevistados presentan una posición desfavorable, en cuanto a las condiciones de la plataforma de apoyo al proceso productivo como estímulo al desarrollo del sector en la región, un 63,4% de los consultados afirman que la infraestructura física para el traslado de mercancías no favorecen la actividad del sector. La mayoría(76,7% de los entrevistados consideró que el funcionamiento de los servicios administrativos del gobierno, constituye un soporte valioso a las actividades empresariales, especialmente en cuanto a la posibilidad de realizar trámites vía Internet.Para la mayoría de las empresas consideradas (60%, el desarrollo urbano del territorio se presenta como una fuerza relativamente débil en el entorno productivo.Se concluye, que la relativa debilidad de ésta fuerza en la región, obedece a las deficiencias en las condiciones de la infraestructura económica, en particular al mantenimiento de la red de carreteras secundarias, así como en la prestación del servicio eléctrico, mientras que la infraestructura institucional resultó fortalecida, por tanto, para elevar el grado de desarrollo será necesario realizar intervenciones a fin de mejorar las condiciones de la infraestructura económica.

  4. DETERMINACIÓN DE LA FUERZA DE LA FRACTURA SUPERFICIAL Y FUERZA DE FIRMEZA EN FRUTAS DE LULO (Solanum quitoense x Solanum hirtum DETERMINATION OF SURFACE FRACTURE AND FIRMNESS FORCE IN LULO FRUIT (Solanum quitoense x Solanum hirtum

    Diana Marcela Ospina Monsalve

    2007-12-01

    Full Text Available Se hizo la caracterización reológica de la fruta de lulo (Solanum quitoense x Solanum hirtun a través de la respuesta mecánica bajo ensayos de compresión unidireccional a pruebas de firmeza y fractura, de acuerdo a dos grados de madurez comercial (pintón y maduro y tiempos de poscosecha (0, 3, 6, 9 días. Adicionalmente se determinaron propiedades físico-químicas tales como concentración de azúcares, pH y color. Las frutas fueron sometidas a ensayos de compresión unidireccional usando un analizador de textura a una velocidad de deformación de 1 mm∙s. Los ensayos para la prueba de fractura se realizaron según dos sentidos de carga (longitudinal y transversal y la prueba de firmeza se determinó en dos ángulos de incidencia. Los resultados mostraron que el comportamiento reológico de la fruta a ensayos de fractura y firmeza es altamente dependiente del tiempo transcurrido después de la cosecha de la fruta y condiciones fisiológicas (grado de madurez, situación ésta que refleja el comportamiento visco elástico y anisotrópico del producto. Los valores de la fuerza de fractura indicaron que la fruta pintona resiste mayor carga de aplastamiento con respecto al fruta madura. La fruta resiste más carga en sentido longitudinal que transversal, mostrando valores para frutas pintonas en posición longitudinal de 226 N y en posición transversal de 84,8 N, y para las frutas maduras se encontró una fuerza de fractura media en posición longitudinal de 180 N y en posición transversal de 68,5N. Para la fuerza de firmeza media (pulpa el valor máximo para frutas maduras fue de 1,4 N, y para frutas pintonas de 1,1 N. La fuerza de firmeza máxima (epicarpio tomó como valores máximos para las frutas maduras 14,4 N y para los frutas pintonas de 15,7 N.A rheological characterization of lulo fruits (Solanum quitoense x Solanum hirtum by using the test of unidirectional compression to firmness and fracture tests, according to two degrees of

  5. The competitive forces of the natural gas industry of Mexico; Las fuerzas competitivas de la industria del gas natural de Mexico

    Buendia Servin de la Mora, Neil Spar [Facultad de Ingenieria, UNAM (Mexico)

    1997-07-01

    The present paper is intended to identify the structural characteristics of the natural gas national industry, that determines the intensity of the forces in competition. To know the ambient where PEMEX-Gas and Basic Petrochemistry will compete, the distributors and the partnerships formed by national and foreign companies is fundamental, since the forces that affect the market determine the attractiveness of the industry, the gain margins, investments, et cetera. [Spanish] En el presente trabajo se pretende identificar las caracteristicas estructurales de la industria nacional del gas natural, que determinan lo intenso de las fuerzas en competencia. Conocer el ambiente en donde competiran PEMEX-Gas y Petroquimica Basica, las distribuidoras nacionales y los consorcios formados por empresas nacionales y extranjeras es primordial, puesto que las fuerzas que inciden al mercado determinan el atractivo de la industria, los margenes de ganancia, inversiones, etcetera.

  6. Procedimientos para el registro de la trazabilidad de los repuestos aeronáuticos para la Fuerza Aérea Colombiana

    Carlos Javier Cuervo Lara

    2007-01-01

    Full Text Available La Fuerza Aérea Colombiana, dado su actual desarrollo, debe adquirir o enviar a reparar una mayor cantidad de elementos aeronáuticos tanto dentro del país como fuera del mismo. Para que este procedimiento termine de forma satisfactoria se debe conocer el origen, el estado y el proveedor de estos elementos. Este conocimiento es denominado trazabilidad y aunque la Fuerza Aérea Colombiana lo aplica, especialmente en las adquisiciones y reparaciones en el exterior, las Unidades no tienen un proceso estándar para su aplicación.

  7. China Dimensions Data Collection: China Administrative Regions GIS Data: 1:1M, County Level, 1990

    National Aeronautics and Space Administration — China Administrative Regions GIS Data: 1:1M, County Level, 1990 consists of geographic boundary data for the administrative regions of China as of 31 December 1990....

  8. Experimental Conditions: SE24_S1_M1_D1 [Metabolonote[Archive

    Full Text Available rometry with 13C‑Labeling for Chemical Assignment of Sulfur-Containing Metabolites ...SE24_S1_M1_D1 SE24 Combination of Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance-Mass Spect

  9. Differential expression of PARP1 mRNA in leucocytes of patients ...

    P. 2011 Differential expression of PARP1 mRNA in leucocytes of patients with Down's syndrome. J. Genet. ... of Alzheimer disease at an earlier age than subjects with- ... family and personal informed consent. .... In effect, they report that.

  10. China Dimensions Data Collection: Fundamental GIS: Digital Chart of China, 1:1M, Version 1

    National Aeronautics and Space Administration — Fundamental GIS: Digital Chart of China, 1:1M, Version 1 consists of vector maps of China and surrounding areas. The maps include roads, railroads, drainage systems,...

  11. VT Data - Lidar nDSM (1m) 2005, Essex County

    Vermont Center for Geographic Information — (Link to Metadata) This metadata applies to the following collection area(s): Essex County 2005 1m and related "normalized" Digital Surface Model (nDSM) data. This...

  12. Are the Guerrillas Gone?: a historical political economy and social analysis of the rise and demise of the Fuerzas Armadas Revolucionarias Columbianas (FARC), 1964-2010

    Castano, Arturo Herrera; Tarrant, Shane L.

    2009-01-01

    Approved for public release, distribution unlimited This thesis looks at how the Revolutionary Armed Forces of Colombia (FARC) was able to survive and control significant parts of Colombia until relatively recently. It also explains the decline of the FARC as a significant insurgency (and as one of the last, if not the last significant guerrilla organization in the region). While a historical political economy and social analysis of the rise and demise of the Fuerzas Armadas Revolucio...

  13. Are the Guerrillas Gone? A Historical Political Economy and Social Analysis of the Rise and Demise of the Fuerzas Armadas Revolucionarias Colombianas (FARC), 1964-2010

    2009-12-01

    directed at the CNP and the Departamento Administrativo de Seguridad (DAS) two separate investigative agencies: Initial reports suggest that CNP...ed.). Bogotá: Ediciones Abejón Mono. Arenas, J., Barco, V., & Fuerzas Armadas Revolucionarias de Colombia. (1990). Vicisitudes del proceso de paz...Organization of American States. (2004, December). II–120 Informe sobre el proceso de Desmobilización en Colombia. Retrieved July 2, 2009, from

  14. EFECTO DEL ENTRENAMIENTO INTEGRADO SOBRE LA MEJORA DE LA FUERZA DE IMPULSIÓN EN UN LANZAMIENTO EN SUSPENSIÓN EN BALONMANO

    P. Padial; I. J. Chirosa; L. J. Chirosa

    2010-01-01

     

    RESUMEN


    Se ha analizado el efecto de dos tipos diferentes de entrenamiento en balonmano, uno que integra carga física y técnica dentro del mismo ejercicio (entrenamiento integrado), y otro que sigue los cánones tradicionales (entrenamiento de fuerza y entrenamiento t&...

  15. Complete Genome Sequence of Methylobacterium populi P-1M, Isolated from Pink-Pigmented Household Biofilm.

    Morohoshi, Tomohiro; Ikeda, Tsukasa

    2016-06-16

    Methylobacterium populi P-1M is isolated from the pink-pigmented household biofilm. Here, we present the complete genome sequence of P-1M, consisting of one chromosome of 5,705,640 bp and five plasmids of 64,864 bp, 59,879 bp, 42,569 bp, 41,417 bp, and 29,506 bp. Copyright © 2016 Morohoshi and Ikeda.

  16. Effect of methanol extract of Prosopis juliflora on mild steel corrosion in 1M HCl

    Zulfareen, Nasarullah; Kannan, Kulanthi; Venugopal, Thiruvengadam

    2016-01-01

    The Prosopis juliflora extract was investigated as a corrosion inhibitor for mild steel in 1M HCl using weight loss measurements, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS). The inhibition efficiency of Prosopis juliflora increases with an increase in inhibitor concentration and temperature. Polarization studies revealed that Prosopis juliflora acts as a mixed type inhibitor for mild steel in 1M HCl. AC impedance indicates that the value of charge transfer ...

  17. Diseño de un sistema de gestión en el manejo de inventarios en la empresa COSSFA S.A. Comisariatos Servicio Social de las Fuerzas Armadas.

    Castellanos Goyes, Verónica Cristina

    2013-01-01

    The preset work shows a management system to manage the company's inventory COSSFA S.A ComisariatosServicio Social de lasFuerzas Armadas. The company was founded in the year 2009 by the Group HOLDINGDINE SA and andactually It is part of the Instituto de Seguridad Social de lasFuerzas Armadas. Showing the management system and the inventory, its importance in business today and how to structure it, in addition to the starting point in devel...

  18. Desarrollo de un modelo generalizado para realimentación de fuerza y torque en cirugía cardiotorácica robótica mínimamente invasiva: determinación de condiciones y restricciones

    Vera Pérez, IEE., PhD.(c

    2011-07-01

    Conclusiones: Las condiciones relacionadas con la incorporación de un sensor de fuerza y la percepción del cirujano en cuanto al tacto y la fuerza aplicada, resultan ser importantes en procedimientos de MICS robótica y requiere la inclusión de un sistema de control que permita la optimización de procedimientos por telepresencia.

  19. EL APRENDIZAJE DE LOS CONCEPTOS DE FUERZAS INTERMOLECULARES E INTRAMOLECULARES MEDIANTE LA MODELIZACIÓN DIDÁCTICA

    CHRISTIAN FERNNEY GIRALDO MACÍAS

    2013-07-01

    Full Text Available La modelización está siendo usada para la enseñanza y el aprendizaje en las Ciencias Naturales en diferentes contextos y para atender a diferentes problemáticas. En este caso será utilizada para explorar y analizar la relevancia que puede tener su uso en el aprendizaje de los conceptos Fuerzas Intramoleculares e Intermolecualres, partiendo de la aplicación de una serie de actividades basadas en el Ciclo Didáctico (Jorba y Sanmartí, 1996. Los datos se discuten mediante tres aspectos principales: las ideas previas de los estudiantes, el trabajo con nuevo material (nuevos conceptos, experimentos sencillos y uso de herramientas informáticas y los argumentos finales, mediante el uso de situaciones problemas. Los resultados muestran, como los estudiantes (14 y 16 años de edad evidencian un progreso conceptual al argumentar con mayor claridad las situaciones problema abordadas en el transcurso del trabajo y en la construcción de modelos más cercanos al campo científico.

  20. Reorganización para la seguridad aérea en la Fuerza Aérea Colombiana

    Edward Jaramillo Sanchez

    2007-01-01

    Full Text Available La investigación estuvo encaminada a la reorganización de la seguridad aérea en la Fuerza Aérea Colombiana, tomando como referencia el Plan Estratégico Institucional 2003-2010 en donde se plantea como objetivo, "Fortalecer los programas de prevención e investigación de accidentes aéreos para evitar la perdida de vidas, de valiosos recursos y el deterioro de la imagen institucional". Con el ánimo de fortalecer esté objetivo, se propone una reorganización de la seguridad que busca el mejoramiento continuo, para obtener resultados favorables ya que los integrantes de la organización saben el papel que desempeñan a nivel grupal dentro de la organización. Lo anterior conduce a un mejor clima organizacional y a lograr mayor eficacia y eficiencia en el desarrollo organizativo, alcanzando los resultados esperados.

  1. Análisis psicométrico del cuestionario de clima laboral de la Fuerza Aérea Colombiana

    Richard Rosero-Burbano

    2012-01-01

    Full Text Available El objetivo del presente estudio fue proponer un instrumento para medir el clima laboral en la Fuerza Aérea Colombiana. Para ello se diseñó el cuestionario de clima laboral, se evaluaron las características psicométricas y se estableció su utilidad como instrumento de medida. El estudio fue de tipo instrumental, con la participación de 3272 de sus funcionarios, diferenciados por grupos de rango, dependencia, jefatura y bases en el ámbito nacional. Se realizó el análisis de ítems para identificar la potencia discriminativa de cada uno de los ítems, para diferenciar entre quiénes tienen alta percepción de un buen clima laboral y los que no la tienen; la homogeneidad y la consistencia interna. Todas las escalas obtuvieron un alpha mayor a 0,72 y del análisis de cada ítem, se propone una escala de 58 elementos. Se concluye que el cuestionario de clima laboral tiene buena capacidad discriminativa y de homogeneidad.

  2. Effects of a strength endurance training program on endurance levels Efectos de un programa de entrenamiento de la fuerza-resistencia sobre los niveles de resistencia

    J. C. Redondo

    2010-09-01

    Full Text Available

    The purpose of the current study was to determine whether a strength endurance training program of lower limbs isolate can increase endurance levels, both aerobic capacity and aerobic power, in order to adapt the strength training for endurance races. 20 phisically active men participated in the study. They were divided into two groups: control group (GC (n=10 and experimental group (GE (n=10. GE carried out a strength endurance training program for ten weeks. Results obtained showed that this type of training regime was useful to improve the performance in an aerobic endurance test. This could be due to an improvement in aerobic capacity, maximal dynamic strength, explosive strength and reactive strength. Moreover, there was a decrease in fat mass without increase in muscle mass.
    Key Words:  Training, strength endurance, aerobic capacity, anthropometry.

     

    El presente estudio pretende comprobar que el trabajo aislado de la fuerza resistencia en miembros inferiores produce una mejora de los niveles de resistencia, en términos tanto de potencia como de capacidad aeróbica, optimizando así el entrenamiento de la fuerza para pruebas de resistencia de media y larga duración. Para ello, veinte sujetos participaron en el estudio, dividiéndose de forma aleatoria en dos grupos: grupo control (GC (n=10 y grupo experimental (GE (n=10 el cual llevó a cabo un entrenamiento de fuerza resistencia extensivo por intervalos, de diez semanas de duración. Los resultados obtenidos muestran que este tipo de entrenamiento es efectivo para mejorar el rendimiento en una prueba de resistencia aeróbica para sujetos físicamente activos, gracias a la mejora de la capacidad aeróbica, de la fuerza máxima dinámica, elástico explosiva y elástico explosivo reactiva y a la disminución de los niveles de grasa

  3. Suppression of Subsequent N1m Amplitude When the Masker Frequency is Different from the Signal

    Yuka Uratani

    2014-01-01

    Full Text Available When two tones are presented in a short interval of time, the presentation of the preceding tone (masker suppresses the response evoked by the subsequent tone (signal. To address the processing in forward suppression, we applied 2- and 4-kHz maskers, followed by a 1-kHz signal at varying signal delays (0 to 320 ms and measured the signal-evoked N1m. A two-way analysis of variance revealed a statistically significant effect for signal delay in both masker presentation conditions. The N1m peak amplitude at the signal delay of 320 ms was significantly larger than those of 10, 20, 40, and 80 ms ( p < 0.05. No significant enhancement for the very short signal delay was observed. The results suggest that the enhancement of N1m peak amplitude for short signal delay conditions is maximized when the frequency of the masker is identical to that of the signal.

  4. Overexpression of protease nexin-1 mRNA and protein in oral squamous cell carcinomas

    Gao, Shan; Krogdahl, Annelise; Sørensen, Jens Ahm

    2007-01-01

    -1 has been almost totally neglected. We have now compared the level of PN-1 mRNA in 20 cases of oral squamous cell carcinomas and in matched samples of the corresponding normal oral tissues. We found that the average PN-1 mRNA level in tumours and normal tissues was significantly different, being...... increased up to 13 fold in tumour samples compared with the average level in normal tissues. The PN-1 mRNA level was significantly higher in tumours from patients with lymph node metastasis than in tumours from patients without. We could conclude that PN-1 is frequently overexpressed in oral squamous cell...... carcinomas and that its level may correlate with the occurrence of lymph node metastasis. We hypothesise that PN-1 may have a tumour biological function similar to that of PAI-1....

  5. Power supply for plasma generator of HL-1M neutral beam injector

    Wang Detai; Qian Jiamei; Lei Guangjiu; Shun Mengda; Jiang Shaofeng; Wang Enyao; Lu Xuejun; Yang Tiehai; Wang Xuehua; Zhao Zhimin; Hao Ming; Huang Jianrong; Yu Yanqiu; Cheng Baoqiang; Wu Zhige; Sheng Ning; Hu Qingtao

    1999-01-01

    The diagram of the HL-1M Neutral Beam Injector (NBI) and the power supply (PS) system is shown. The NBI consists of ion source, beam line and power supply system etc. The ion source includes plasma generator and three-electrode extraction system. The power supply for plasma generator consists of a filament PS, an arc PS and gas valve PS. Testing has shown that the PS for plasma generator of the HL-1M NBI has excellent stability and obtain good plasma heating effect

  6. RESPUESTAS CARDIOVASCULARES AL ENTRENAMIENTO DE FUERZA BAJO OCLUSIÓN VASCULAR [Cardiovascular responses to strength training under occlusive training

    Sergio Benito Hernández

    2013-11-01

    Full Text Available El entrenamiento de la fuerza bajo oclusión vascular se muestra como una alternativa al entrenamiento de alta intensidad. El presente estudio muestra las respuestas cardiovasculares a este tipo de entrenamiento. 10 sujetos fueron sometidos a dos protocolos de entrenamiento oclusivo diferenciados por el peso levantado, (30% del peso máximo, post30, y 70% del peso máximo, post70. Se registraron los valores de tensión arterial sistólica (TAS, diastólica (TAD y frecuencia cardiaca (FC. Los resultados evidencian disminución significativa en TAS y TAD en el grupo post30 en 7 y 13 mm Hg respectivamente en referencia a los valores basales (p<0.05, resultando un descenso muy significativo en el grupo post70, 14 y 20 mm Hg respectivamente (p<0.005. Los valores de la FC no se vieron alterados por ninguno de los protocolos experimentales (p>0.05. Los efectos de tamaño para todos los grupos resultaron triviales (d<0.25. En conclusión los resultados del presente estudios presentan una tendencia a la reducción de la tensión arterial significativa en TAS y TAD en los protocolos de entrenamiento oclusivo, resultando más notable cuando se aplica la mayor intensidad de entrenamiento. Resultan necesarios más estudios que examinen el comportamiento de los parámetros cardiovasculares tras el entrenamiento de fuerza bajo oclusión vascular.AbstractOcclusive strength training is shown like an alternative to intensive training. Present study shown cardiovascular responses to this training. 10 subjects were subjected to two occlusion training protocols, differentiated by the weight lifted (30 % of maximum weight lifted, post30, and 70 % of maximum weight lifted, post70. The values of arterial systolic tension (TAS, diastolic (TAD and heart rate (FC were recorded. The results showing a significant decline in TAS and TAD after post30 of 7 and 13 mm Hg respectively from basis values (p<0.05, resulting a very significant decline in post70 group, 14 and 20 mm Hg

  7. Perspectivas moleculares y metabólicas de la suplementación con creatina en el entrenamiento de fuerza

    Diego A. Bonilla

    2015-01-01

    Full Text Available En los últimos años el problema de investigación en el campo de la suplementación deportiva ha cambiado al punto de explicar los mecanismos metabólicos por los cuales la administración de creatina (Cr incrementa el rendimiento en ciertos deportes o simplemente beneficia la adaptación muscular. Esta revisión analiza por primera vez los mecanismos bioquímicos de la ingesta de Cr desde la perspectiva de señalización celular, enfocándose en la mayor biodisponibilidad energética de Cr y optimización de la acción buffer espacial/ temporal que ofrece el sistema Cr/PCr/CK. Además, se examinan aspectos relacionados con el incremento en los procesos de proliferación y diferenciación de células musculares (IGF-I/PI3K/Akt-PKB, SPHK1/ MAPK/p38/MRFs, mTOR, hinchamiento celular, actividad mitótica de células satélite, polimerización de actina y fusión de mioblastos y la inactivación y/o reducción en la expresión de proteínas con funciones ergolíticas (GSK3β, miostatina y regulación de AMPK. De esta manera, se explican el aumento de la masa muscular, la fuerza, la resistencia a la fatiga y el rendimiento en ejercicios de alta intensidad, producidos por la suplementación con monohidrato de Cr, desde un punto de vista metabólico.

  8. Maduración biológica, fuerza y potencia muscular en la brazada de crol

    Richard R. Casanova Machek

    2017-06-01

    Full Text Available Se trata de una investigación de campo, de tipo correlacional que buscó determinar la relación entre la maduración biológica y la potencia muscular de los miembros superiores en nadadores de categorías menores. Se evaluaron 23 niños(as edades comprendidas entre los 10 y los 13 años. La muestra se caracterizó a través de mediciones antropométricas: estatura, masa corporal, envergadura, composición corporal y superficie corporal, maduración sexual (Tanner, 1975. Se aplicó Test de Wingate (laboratorio y piscina según Dotan y Bar-Or (1983 y Morouco (2009 para miembros superiores para estimar potencia máxima, potencia relativa, potencia promedio, índice de fatiga. Los datos se presentan en medidas de tendencia central y dispersión; se calcularon las diferencias de un factor y se estimaron las correlaciones con la técnica Pearson y Spearman. Los resultados indican que el entrenamiento fuera del agua influyó en el rendimiento dentro del agua. El tamaño de las dimensiones corporales y el número de horas de entrenamiento tiene incidencia sobre la potencia producida por los nadadores, con diferencias notables a partir de los 10 años. Las dimensiones corporales y la mayor frecuencia de entrenamiento semanal generan valores altos de potencia muscular. Se recomienda realizar evaluaciones periódicas de fuerza y potencia, crear y mantener actualizado el perfil antropométrico, aplicar cuestionario de autoevaluación de caracteres de maduración sexual y ajustar los periodos de duración de las horas de entrenamiento, en tanto se incrementen las edades.

  9. EFECTO DE DIFERENTES MÉTODOS DE ENTRENAMIENTO DE CONTRASTE PARA LA MEJORA DE LA FUERZA DE IMPULSIÓN EN UN SALTO VERTICAL

    P. Padial

    2010-09-01

    Full Text Available

     

    RESUMEN

    La finalidad del presente estudio es conocer el efecto de dos tipos de entrenamiento de contraste de fuerza en los que se combinan cargas ligeras (multisaltos con cargas pesadas (sentadillas al 70% del 1RM sobre las distintas manifestaciones de la fuerza dinámica. La muestra seleccionada se extrajo del Ejercito Español de Tierra, divididos en dos grupos experimentales (n=30: 15 en cada grupo, varones, 22 ± 4 años de edad, sin que existiera para ello grupo control. La razón de este diseño, sin grupo control, es porque está suficientemente comprobado por la literatura científica que el entrenamiento de contraste de fuerza produce ganancias significativas en la altura del salto. La variable independiente manipulada es la forma de combinación de las cargas: en el grupo 1 la combinación de cargas se realiza en la misma serie (grupo de contraste en la serie –CSR- y en el grupo 2 la combinación de cargas se realiza en la misma sesión (grupo de contraste en la sesión – CSS-.Por lo tanto, lo que se trata de determinar es qué método de contraste, de los dos empleados, es más eficaz. Procedimiento: Ambos grupos experimentales entrenaron 3 veces a la semana, durante 8 semanas consecutivas. La intensidad del entrenamiento y la carga fue la misma para los dos grupos. Se realizaron controles, mediante una alfombra de contacto, al inicio y en la 4ª y 8ª semana de la experimentación. Se evaluó la altura de salto siguiendo el protocolo de Bosco: salto sin contramomivimiento (SJ, salto con controamovimiento (CMJ, salto sin contramovimiento con el 50% de peso corporal (SJ50, salto sin contramovimiento con el 100% de peso corporal (SJ100 y la fuerza máxima del tren inferior mediante una repetición máxima -1RM en sentadilla-. Resultados: Tras el correspondiente an

  10. A WEB-based integrated data processing system for the TRIAM-1M

    Hasegawa, M.; Higashijima, A.; Nakamura, K.; Hanada, K.; Sato, K.N.; Sakamoto, M.; Idei, H.; Kawasaki, S.; Nakashima, H.

    2008-01-01

    In TRIAM-1M, plasma discharge can be sustained for over five hours [H. Zushi, et al., Steady-state tokamak operation, ITB transition and sustainment and ECCD experiments in TRIAM-1M, Nucl. Fusion 45 (2005) S142-S156]. In order to avoid sitting in front of one console for the purpose of monitoring the plasma discharge, it is recommended that the experimental information be accessible from any location at any time. In addition, simple services to access experimental information are required in order to promote the participation of multiple researchers in the TRIAM-1M experiment. Thus, A WEB-based integrated data processing system that provides management for experiment planning, an experimental log, numerical data, and plasma supervision has been installed in the TRIAM-1M. These services are composed primarily of an Apache WEB server, a Tomcat JSP/Servlet container, and a MySQL relational database. This system is constructed using the object-oriented Java language, which is easy to maintain and develop because of the intrinsic characteristics of the Java language. When participating in experiments, researchers are required only to prepare a WEB browser on any platform and are no longer required to memorize complex operations because all services are provided with a uniform user interface through a WEB browser. Furthermore, with the integration of these services, the required information and numerical data can be provided promptly by tracing HTML links that are created dynamically by server applications

  11. A WEB-based integrated data processing system for the TRIAM-1M

    Hasegawa, M. [Advanced Fusion Research Center, Research Institute for Applied Mechanics, Kyushu University, Fukuoka 816-8580 (Japan)], E-mail: hasegawa@triam.kyushu-u.ac.jp; Higashijima, A; Nakamura, K; Hanada, K; Sato, K N; Sakamoto, M; Idei, H; Kawasaki, S; Nakashima, H [Advanced Fusion Research Center, Research Institute for Applied Mechanics, Kyushu University, Fukuoka 816-8580 (Japan)

    2008-05-15

    In TRIAM-1M, plasma discharge can be sustained for over five hours [H. Zushi, et al., Steady-state tokamak operation, ITB transition and sustainment and ECCD experiments in TRIAM-1M, Nucl. Fusion 45 (2005) S142-S156]. In order to avoid sitting in front of one console for the purpose of monitoring the plasma discharge, it is recommended that the experimental information be accessible from any location at any time. In addition, simple services to access experimental information are required in order to promote the participation of multiple researchers in the TRIAM-1M experiment. Thus, A WEB-based integrated data processing system that provides management for experiment planning, an experimental log, numerical data, and plasma supervision has been installed in the TRIAM-1M. These services are composed primarily of an Apache WEB server, a Tomcat JSP/Servlet container, and a MySQL relational database. This system is constructed using the object-oriented Java language, which is easy to maintain and develop because of the intrinsic characteristics of the Java language. When participating in experiments, researchers are required only to prepare a WEB browser on any platform and are no longer required to memorize complex operations because all services are provided with a uniform user interface through a WEB browser. Furthermore, with the integration of these services, the required information and numerical data can be provided promptly by tracing HTML links that are created dynamically by server applications.

  12. Alternative splicing of cyclooxygenase-1 mRNA in the human iris

    Dröge, M.J; van Sorge, A.A; van Haeringen, N.J; Quax, Wim; Zaagsma, Hans; Droge, MJ

    2003-01-01

    dIn homogenates of the human iris, the nonsteroidal antiinflammatory drug (NSAID) S(+)flurbiprofen has been reported to inhibit cyclooxygenase-1 (COX-1) 70-fold more potently than in human whole blood. We hypothesized that this difference may be due to alternative splicing of COX-1 mRNA in the human

  13. Characterization and commissioning of the SST-1M camera for the Cherenkov Telescope Array

    Aguilar, J.A.; Bilnik, W.; Blocki, J.; Bogacz, L.; Borkowski, J.; Bulik, T.; Cadoux, F.; Christov, A.; Curylo, M.; della Volpe, D.; Dyrda, M.; Favre, Y.; Frankowski, A.; Grudnik, L.; Grudzinska, M.; Heller, M.; Idzkowski, B.; Jamrozy, M.; Janiak, M.; Kasperek, J.; Lalik, K.; Lyard, E.; Mach, E.; Mandát, Dušan; Marszalek, A.; Medina Miranda, L. D.; Michałowski, J.; Moderski, R.; Montaruli, T.; Neronov, A.; Niemiec, J.; Ostrowski, M.; Pasko, P.; Pech, Miroslav; Porcelli, A.; Prandini, E.; Rajda, P.; Rameez, M.; Schioppa, E.; Schovánek, Petr; Seweryn, K.; Skowron, K.; Sliusar, V.; Sowinski, M.; Stawarz, L.; Stodulska, M.; Stodulski, M.; Toscano, S.; Troyano Pujadas, I.; Walter, R.; Wiecek, M.; Zagdanski, A.; Zietara, K.; Zychowski, P.

    2017-01-01

    Roč. 845, Feb (2017), s. 350-354 ISSN 0168-9002 Institutional support: RVO:68378271 Keywords : SiPM * G-APD * CTA * SST-1 M * Gamma-ray Astronomy * FPGA * PhotoDetection * high-speed electronics * ADC Subject RIV: BF - Elementary Particles and High Energy Physics OBOR OECD: Particles and field physics Impact factor: 1.362, year: 2016

  14. Inclusive semi-tauonic B decays to higher order in 1/m{sub b}

    Mannel, Thomas; Shahriaran, Farnoush [University of Siegen (Germany)

    2015-07-01

    Starting from an Operator Product Expansion in the Heavy Quark Effective Theory we calculate the differential decay rate for inclusive B → X{sub c}τν transitions to order 1/m{sub b}{sup 4} for the unpolarized τ leptons at tree level.

  15. Data of evolutionary structure change: 1M3DI-1T60W [Confc[Archive

    Full Text Available tryIDChain>1M3DI APLPM--MPVAE ...> -- EEE> ATOM 14546 CA ALA I 86 32.542 22.976 78.017 1.00...ain>1T60W EPMPMSMAPITG > EEE> IECHG-RGTCN >EEEE - EEEE.../entryIDChain> IECNGARGTCH >EEEEGGGEEEE>

  16. Matching of heavy-light flavour currents between HQET at order 1/m and QCD

    Della Morte, Michele; Dooling, Samantha; Heitger, Jochen

    2014-01-01

    We present a strategy how to match the full set of components of the heavy-light axial and vector currents in Heavy Quark Effective Theory (HQET), up to and including 1/m-corrections, to QCD. While the ultimate goal is to apply these matching conditions non-perturbatively, in this study we first...

  17. Evaluation on a radioimmunoassay of. alpha. /sub 1/ microglobulin (. alpha. /sub 1/-m) with simplified procedures

    Matsui, Kazuyo; Moriuma, Hatsuko; Mishima, Chiho; Honda, Minoru; Tomonobu, Masahiro; Kanao, Keisuke; Fushimi, Hisako (Sumitomo Hospital, Osaka (Japan))

    1989-06-01

    A newly established double antibody radioimmunoassay (RIA) was fundamentally and clinically evaluated. Original procedures were partially modified as follows: Sample volume for serum and urine was changed to 25{mu}l, and thus 200 mg/l of {alpha}/sub 1/-m standard was prepared using 50 {mu}l of original standard solution (100 mg/l). The results were satisfactory in sensitivity (0.3 mg/l obtained from -2SD method), intraassay precision with its coefficient variation (CV) ranging from 3.0 to 7.4%, interassay precision with its CV ranging from 3.0 to 10.7%, and recovery with the mean value of 102.4% in serum and 108.2% in urine respectively. There were no changes about {alpha}/sub 1/-m value between diluted (2 times) and undiluted with high concentration samples. Normal levels of {alpha}/sub 1/-m were less than 25 mg/l is serum and less than 10 mg/l in urine. The present results indicate that the determination of {alpha}/sub 1/-m could be very simple and useful for the most sensitive screening test for the evaluation of renal function. (author).

  18. The computer code Eurdyn - 1 M. (Release 1) Part 2: User's Manual

    Donea, J.; Giuliani, S.

    1979-01-01

    This report is the user's manual for the computer code Eurdyn-1 M developed at the J.R.C. Ispra for use in containment and fuel subassembly analyses for fast reactor safety studies. The input data are defined and a test problem is presented to illustrate both the input and the output of results

  19. Generation of 2.1 m wavelength from degenerate high gray track ...

    2014-02-12

    Feb 12, 2014 ... Home; Journals; Pramana – Journal of Physics; Volume 82; Issue 2. Generation of 2.1 m wavelength from degenerate high gray track resistant potassium titanyl phosphate optical parametric oscillator. S Verma C Mishra V Kumar M Yadav K C Bahuguna N S Vasan S P Gaba. Contributed Papers Volume ...

  20. Analysis of the plasma magnetohydrodynamic equilibrium in iron core transformer Tokamak HL-1M

    Chen Xiaoguang; Yuan Baoshan

    1992-01-01

    The physical and mathematical model are presented on the problem of MHD equilibrium with the self consistent in iron core transformer HL-1M. Calculation and analysis for the plasma equilibrium of the stable boundary and free boundary are shown respectively, in an axisymmetric equilibrium model of two dimensions. First, a variation formulation of the problem is written and the equations of the poloided flux ψ are solved by a finite element method; the Picard and Newton algorithms are tested for the non-linearities. The plasma boundary and the magnetic surfaces are being simulated, with the currents in the coils, the total plasma current, its current density function and the magnetic permeability of the iron being the data for the problem; a certain number of the characteristic parameter of the equilibrium configuration is calculated. Secondly, a simple method of calculation is adopted in the determination of equilibrium fields and currents in iron core HL-1M tokamak device. In the plasma equilibrium, the magnetic effect of the air gaps in the iron core and the iron magnetic shielded plate are considered in HL-1M device. Reliable data are provided for designing and constructing the poloidal field system of HL-1M device. A good computer code is constructed, which may be useful in operating on analysis for the future device

  1. Expression and clinicopathological significance of Mel-18 and Bmi-1 mRNA in gastric carcinoma.

    Lu, You-Wei; Li, Jin; Guo, Wei-Jian

    2010-11-08

    The Polycomb group (PcG) genes are a class of regulators responsible for maintaining homeotic gene expression throughout cell division. PcG expression is deregulated in some types of human cancer. Both Bmi-1 and Mel-18 are of the key PcG proteins. We investigate the expression and clinicopathological roles of Mel-18 and Bmi-1 mRNA in gastric cancer. The expression of Mel-18 and Bmi-1 in a series of 71 gastric cancer tissues and paired normal mucosal tissues distant from the tumorous lesion was assayed by quantitative real time RT-PCR. The correlation between Mel-18 and Bmi-1 mRNA expression, and between Mel-18 or Bmi-1 mRNA level and clinicopathological characteristics were analyzed. Expression of Mel-18 and Bmi-1 genes was variably detected, but overexpression of Bmi-1 mRNA and decreased expression of Mel-18 mRNA were the most frequent alteration. In addition, the expression of Bmi-1 and Mel-18 mRNA inversely correlates in gastric tumors. Moreover, a significant positive correlation between Bmi-1 overexpression and tumor size, depth of invasion, or lymph node metastasis, and a significant negative correlation between Mel-18 low-expression with lymph node metastasis or the clinical stage were observed. Our data suggest that Mel-18 and Bmi-1 may play crucial but opposite roles in gastric cancer. Decreased Mel-18 and increased Bmi-1 mRNA expression was associated with the carcinogenesis and progression of gastric cancer. It is possible to list Bmi-1 and Mel-18 as biomarkers for predicting the prognosis of gastric cancer.

  2. Evaluación de la asimetría y el déficit bilateral de los extensores de la rodilla en diferentes manifestaciones de la fuerza = Asymetry and bilateral deficit's assessment of knee extensors in the different manifestations of strength

    Pérez-Landaluce González, Juan

    2016-01-01

    El objetivo esencial de este estudio fue, evaluar y cuantificar el déficit bilateral y la asimetría, de la masa muscular encargada de la extensión de la rodilla, en tres manifestaciones de la fuerza. Para dar respuesta a la hipótesis planteada, se llevaron a cabo varias pruebas, una para cada manifestación de la fuerza estudiada: fuerza isométrica máxima, fuerza dinámica máxima y potencia. Los resultados obtenidos concluyeron que no había diferencias significativas para la asimetría, y en cua...

  3. Estudio del rendimiento del torneado de alta velocidad utilizando el coeficiente de dimensión volumétrica de la fuerza de corte resultante

    Hernández-González, L. W.

    2013-08-01

    Full Text Available This work deals with the experimental study of the resultant cutting force evolution of two coating carbide and a cermet inserts, during the dry turning of AISI 1045 steel with 400, 500 and 600 m/min cutting speeds. A new criterion for machinability study, the coefficient of volumetric dimension of cutting force, it is introduced. The investigation showed a better performance of cermet for moderate and intermediate cutting speeds, while at high cutting speed and final machining time, the three layers coated carbide achieved the best result. The factorial analysis of variance demonstrated a significant effect of machining time on the coefficient of volumetric dimension of resultant cutting force, while the material insert factor and their interaction, for intermediate cutting speed was just significant.En este trabajo se aborda el estudio experimental de la evolución de la fuerza de corte resultante de dos insertos de carburo recubierto y un cermet, durante el torneado en seco del acero AISI 1045 con velocidades de corte de 400, 500 y 600 m/min . Se introduce, además, un nuevo criterio para el estudio del rendimiento de las operaciones de mecanizado: el coeficiente de dimensión volumétrica de la fuerza de corte. La investigación mostró un mejor rendimiento del cermet para la velocidad de corte moderada e intermedia, mientras que para la alta velocidad de corte y tiempo final de mecanizado, el mejor resultado fue para el carburo recubierto con tres capas. El análisis de varianza factorial demostró un efecto significativo del tiempo de mecanizado en el coeficiente de dimensión volumétrica de la fuerza de corte resultante, mientras que la variable material del inserto y su interacción, fue solo significativa para la velocidad de corte intermedia.

  4. Análisis del potencial competitivo del bioetanol en colombia: un enfoque desde las 5 fuerzas competitivas de michael porter

    RAMIREZ VELASQUEZ, ALEJANDRO; MONTOYA R., IVÁN ALONSO; MONTOYA RESTREPO, ALEXANDRA

    2012-01-01

    La búsqueda de alternativas de producción y consumo energético requiere una mirada hacia la industria de los combustibles biológicos como el bioetanol que, como alternativa energética, permita superar los inconvenientes generados por los métodos tradicionales de producción y consumo, en especial en los temas políticos, ambientales y sociales y generar ventajas competitivas frente a otras fuentes primarias de energía. En el presente documento,a partir del modelo de las cinco (5) Fuerzas de Mic...

  5. GOBERNANZA PARA LA GOBERNABILIDAD. LA CONSTRUCCIÓN DE “FUERZA CIVIL”, LA NUEVA POLICÍA DE NUEVO LEÓN

    Héctor Eduardo Mendoza Márquez; Juan Carlos Montero Bagatella

    2015-01-01

    El siguiente trabajo expone el proceso de construcción de la nueva policía estatal de Nuevo León: Fuerza Civil. La importancia de la institución, radica en que ha sido reconocida como un ejemplo a nivel nacional y en la actualidad ya es replicada en varios estados de la república. En particular, el artículo destaca la formación de la Alianza por la Seguridad como un elemento fundamental para el diseño e implementación de la política de seguridad pública, en un ejercicio de gobernanza du...

  6. Ganando fuerza para el ejercicio de nuestra ciudadanía: Guía dirigida a mujeres y personas trans que realizan trabajo sexual

    Vargas Valente, María Elizabeth

    2009-01-01

    A partir de 2005 el UNFPA ha asumido la responsabilidad de apoyar los esfuerzos de prevención y acceso a servicios de salud de las poblaciones más vulnerables frente a la epidemia del VIH, particularmente las trabajadoras sexuales, especialmente en países como el Perú donde la epidemia está concentrada en algunos subgrupos de la población. Es por ello que hoy nos complace presentar la Guía de Capacitación Ganando Fuerza para el Ejercicio de Nuestra Ciudadanía, dirigida a mujeres y personas tr...

  7. La Cooperativa de Luz y Fuerza de Río Tercero: una institución al servicio de su comunidad, 1933- 1953

    María Elena Rodríguez

    2006-01-01

    Full Text Available En nuestro país, las cooperativas eléctricas surgieron a partir de la década de 1920 como reacción popular frente a las elevadas tarifas y al deficiente servicio proporcionado por las empresas de capital extranjero que tenían a su cargo la generación y la distribución de energía. La provincia de Córdoba no fue ajena a este fenómeno, en este artículo nos proponemos mostrar las circunstancias en que surgió la Cooperativa de Luz y Fuerza de Río Tercero en 1933, la que a diferencia de otras de la provincia de Córdoba no generaba la energía que distribuía sino que la compraba a la usina hidráulica del dique Río Tercero, y al mismo tiempo resaltar también su evolución y las repercusiones de su gestión durante las dos primeras décadas de vida en las que prestó el servicio de energía eléctrica y comenzó con las gestiones encaminadas a concretar la provisión de agua corriente a la población de Río Tercero, convirtiéndose en la Cooperativa de Luz y Fuerza y Agua Potable de Río Tercero Limitada inaugurando ese servicio en 1953.In our country, the electric cooperatives appeared in the 1920's decade as a popular reaction against the high bills and deficient service given by the enterprices of abroad capital that were in charge of energy generation and distribution.The Córdoba's province was not indifferent to this phenomenon, in this article we have the purpose to show the circumstances in which have place the Cooperativa de Luz y Fuerza de Río Tercero in 1933, this was different from the others in Córdoba's province because it did not generate the energy that distributed but bought it to the hydraulic usine of Rio Tercero's dock, and at the same time we want to rebound its evolution and the repercussions of its work during its first two decades of life in which it supplied of electric energy and began to negotiate to bring running water to the population of Rio Tercero, inaugurating that service in 1953 and becoming

  8. El plan de desarrollo de la Fuerza Armada Nacional Bolivariana, "Plan Sucre 2007-2013”, y las implicaciones para la seguridad nacional de Colombia

    Hurtado, Camilo; Cadena Afanador, Walter René

    2015-01-01

    Este trabajo de investigación analiza, desde la cosmovisión neorrealista de las Relaciones Internacionales, los alcances del Plan de Desarrollo de la Fuerza Armada Nacional Bolivariana, Plan Sucre, y las repercusiones que su consolidación tendrá para la seguridad nacional de Colombia. Inicialmente se plantea un marco teórico y conceptual, lo cual permite avanzar al segundo capítulo el cual tiene como propósito fundamental describir en qué consiste el Plan Sucre. El capítulo tres analiza los a...

  9. El entrenamiento de la fuerza para la mejora del rendimiento físico-deportivo y la prevención de lesiones en el fútbol

    Raya González, Javier

    2017-01-01

    Programa de Doctorado en Ciencias de la Actividad Física y del Deporte Esta Tesis Doctoral versa sobre el fútbol, respecto a sus características y la aplicación de un entrenamiento de fuerza con sobrecarga excéntrica que incrementa en pocas semanas la potencia del tren inferior, y produce otras mejoras en variables relacionadas con el rendimiento en el fútbol. También se estudian los efectos de 2 programas de entrenamiento neuromuscular con diferente orientación, para conocer la mejora de ...

  10. Propuesta de planificación y periodización de la fuerza en el judo en deportistas de alto nivel

    Sánchez Delgado, Sergio

    2014-01-01

    En el presente trabajo se plantea una planificación de la fuerza alternativa para el judo en el alto nivel. Para ello, se han propuesto sesiones de entrenamiento específicas en tatami, así como específicas en gimnasio, así como una distribución de dichas sesiones durante las semanas de trabajo. Todo esto, en diferentes momentos de la temporada, los cuales hemos llamado periodos, que perseguirán unos objetivos concretos de una manera concreta y secuencializada.

  11. Relaci??n entre la masa muscular, la densidad mineral ??sea, la fuerza muscular, la aptitud funcional y la calidad muscular en personas mayores

    Pati??o Villada, Fredy Alonso

    2015-01-01

    294 p. La tesis pretende determinar la frecuencia de la sarcopenia y osteporosis , problemas que afectan a la salud de las personas mayores, y analizar la relaci??n entre la masa muscular, la densidad mineral ??sea (DMO), la fuerza muscular, la aptitud funcional y la calidad muscular (CM). La muestra estudiada fue la formada por un grupo de 83 hombres y 175 mujeres mayores de Le??n (Espa??a). El estudio transversal eval??a ??ndices de masa grasa y densidad mineral ??sea y niveles d...

  12. HQET at order 1/m. Pt. 1. Non-perturbative parameters in the quenched approximation

    Blossier, Benoit [Paris XI Univ., 91 - Orsay (France). Lab. de Physique Theorique; Della Morte, Michele [Mainz Univ. (Germany). Inst. fuer Kernphysik; Garron, Nicolas [Universidad Autonoma de Madrid (Spain). Dept. Fisica Teorica y Inst. de Fisica Teorica UAM/CSIC; Edinburgh Univ. (United Kingdom). School of Physics and Astronomy - SUPA; Sommer, Rainer [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC

    2010-01-15

    We determine non-perturbatively the parameters of the lattice HQET Lagrangian and those of heavy-light axial-vector and vector currents in the quenched approximation. The HQET expansion includes terms of order 1/m{sub b}. Our results allow to compute, for example, the heavy-light spectrum and B-meson decay constants in the static approximation and to order 1/m{sub b} in HQET. The determination of the parameters is separated into universal and non-universal parts. The universal results can be used to determine the parameters for various discretizations. The computation reported in this paper uses the plaquette gauge action and the ''HYP1/2'' action for the b-quark described by HQET. The parameters of the currents also depend on the light-quark action, for which we choose non-perturbatively O(a)-improved Wilson fermions. (orig.)

  13. Snake perturbations during pellet injection and LHCD in the HL-1M tokamak

    Liu Yi; Qiu Xiaoming; Dong Yunbo; Zhong Yunzhe; Fu Bingzhong; Jiafu Dong Yong Liu

    2005-01-01

    Excitation of snake perturbations has been observed in the core region of pellet-fuelled HL-1M plasmas when the pellets cross surface with q value 1. Through measurements of plasma q profile by means of multi-exposures with CCD camera during pellet ablation, and investigation on pellet ablation process, possible mechanisms for the formation of snake oscillation are discussed. In addition, a large, long-lived snake-like oscillation is frequently observed in lower hybrid current driven discharge in which the sawtooth has been stabilized at early times. There is evidence that such a perturbation is due to impurity accumulation during sawtooth-stabilization, and the good performance with peaking profiles after LHCD is limited by magnetohydrodynamic (MHD) instabilities including sawtooth and snake activities in HL-1M plasma. (author)

  14. HQET at order 1/m. Pt. 1. Non-perturbative parameters in the quenched approximation

    Blossier, Benoit; Della Morte, Michele; Garron, Nicolas; Edinburgh Univ.; Sommer, Rainer

    2010-01-01

    We determine non-perturbatively the parameters of the lattice HQET Lagrangian and those of heavy-light axial-vector and vector currents in the quenched approximation. The HQET expansion includes terms of order 1/m b . Our results allow to compute, for example, the heavy-light spectrum and B-meson decay constants in the static approximation and to order 1/m b in HQET. The determination of the parameters is separated into universal and non-universal parts. The universal results can be used to determine the parameters for various discretizations. The computation reported in this paper uses the plaquette gauge action and the ''HYP1/2'' action for the b-quark described by HQET. The parameters of the currents also depend on the light-quark action, for which we choose non-perturbatively O(a)-improved Wilson fermions. (orig.)

  15. 1/mQ corrections to form factors and extraction of |Vcb|

    Liu, J.; Chao, K.

    1997-01-01

    Form factors for 0 - →0 - and 0 - →1 - mesonic transitions in the heavy quark limit and the 1/m Q corrections are analyzed model independently within the Bethe-Salpeter (BS) formalism. The analysis shows that the BS formalism has spin-flavor symmetry in the heavy quark limit and respects Luke's theorem when the 1/m Q corrections are taken into account. All form factors for B→D (*) transitions beyond the zero recoil point are estimated in a relativistic constituent quark model based on the BS formalism. Using these form factors we calculate the branching ratios for the semileptonic decays B→D (*) l + ν l and extract the Cabibbo-Kobayashi-Maskawa matrix element |V cb |. We get |V cb |=0.042±0.003 which is consistent with the current world average. copyright 1997 The American Physical Society

  16. Forbidden Raman scattering processes. I. General considerations and E1--M1 scattering

    Harney, R.C.

    1979-01-01

    The generalized theory of forbidden Raman scattering processes is developed in terms of the multipole expansion of the electromagnetic interaction Hamiltonian. Using the general expressions, the theory of electric dipole--magnetic dipole (E1--M1) Raman scattering is derived in detail. The 1 S 0 → 3 P 1 E1--M1 Raman scattering cross section in atomic magnesium is calculated for two applicable laser wavelengths using published f-value data. Since resonantly enhanced cross sections larger than 10 -29 cm 2 /sr are predicted it should be possible to experimentally observe this scattering phenomenon. In addition, by measuring the frequency dependence of the cross section near resonance, it may be possible to directly determine the relative magnitudes of the Axp and AxA contributions to the scattering cross section. Finally, possible applications of the effect in atomic and molecular physics are discussed

  17. Estimation and Properties of a Time-Varying GQARCH(1,1-M Model

    Sofia Anyfantaki

    2011-01-01

    analysis of these models computationally infeasible. This paper outlines the issues and suggests to employ a Markov chain Monte Carlo algorithm which allows the calculation of a classical estimator via the simulated EM algorithm or a simulated Bayesian solution in only ( computational operations, where is the sample size. Furthermore, the theoretical dynamic properties of a time-varying GQARCH(1,1-M are derived. We discuss them and apply the suggested Bayesian estimation to three major stock markets.

  18. Development of a 1-m plasma source for heavy ion beam charge neutralization

    Efthimion, Philip C.; Gilson, Erik P.; Grisham, Larry; Davidson, Ronald C.; Yu, Simon; Waldron, William; Grant Logan, B.

    2005-05-01

    Highly ionized plasmas are being employed as a medium for charge neutralizing heavy ion beams in order to focus to a small spot size. Calculations suggest that plasma at a density of 1-100 times the ion beam density and at a length ˜0.1-1 m would be suitable for achieving a high level of charge neutralization. A radio frequency (RF) source was constructed at the Princeton Plasma Physics Laboratory (PPPL) in support of the joint Neutralized Transport Experiment (NTX) at the Lawrence Berkeley National Laboratory (LBNL) to study ion beam neutralization. Pulsing the source enabled operation at pressures ˜10 -6 Torr with plasma densities of 10 11 cm -3. Near 100% ionization was achieved. The plasma was 10 cm in length, but future experiments require a source 1 m long. The RF source does not easily scale to the length. Consequently, large-volume plasma sources based upon ferroelectric ceramics are being considered. These sources have the advantage of being able to increase the length of the plasma and operate at low neutral pressures. The source will utilize the ferroelectric ceramic BaTiO 3 to form metal plasma. A 1 m long section of the drift tube inner surface of NTX will be covered with ceramic. A high voltage (˜1-5 kV) is applied between the drift tube and the front surface of the ceramic by placing a wire grid on the front surface. Plasma densities of 10 12 cm -3 and neutral pressures ˜10 -6 Torr are expected. A test stand to produce 20 cm long plasma is being constructed and will be tested before a 1 m long source is developed.

  19. Development of a 1-m plasma source for heavy ion beam charge neutralization

    Efthimion, Philip C.; Gilson, Erik P.; Grisham, Larry; Davidson, Ronald C.; Yu, Simon; Waldron, William; Grant Logan, B.

    2005-01-01

    Highly ionized plasmas are being employed as a medium for charge neutralizing heavy ion beams in order to focus to a small spot size. Calculations suggest that plasma at a density of 1-100 times the ion beam density and at a length ∼0.1-1 m would be suitable for achieving a high level of charge neutralization. A radio frequency (RF) source was constructed at the Princeton Plasma Physics Laboratory (PPPL) in support of the joint Neutralized Transport Experiment (NTX) at the Lawrence Berkeley National Laboratory (LBNL) to study ion beam neutralization. Pulsing the source enabled operation at pressures ∼10 -6 Torr with plasma densities of 10 11 cm -3 . Near 100% ionization was achieved. The plasma was 10 cm in length, but future experiments require a source 1 m long. The RF source does not easily scale to the length. Consequently, large-volume plasma sources based upon ferroelectric ceramics are being considered. These sources have the advantage of being able to increase the length of the plasma and operate at low neutral pressures. The source will utilize the ferroelectric ceramic BaTiO 3 to form metal plasma. A 1 m long section of the drift tube inner surface of NTX will be covered with ceramic. A high voltage (∼1-5 kV) is applied between the drift tube and the front surface of the ceramic by placing a wire grid on the front surface. Plasma densities of 10 12 cm -3 and neutral pressures ∼10 -6 Torr are expected. A test stand to produce 20 cm long plasma is being constructed and will be tested before a 1 m long source is developed

  20. V and Nb Influence on the Austenitic Stainless Steel Corrosion in 0.1 M HCl

    Amel GHARBI

    2014-05-01

    Full Text Available Vanadium and niobium were added in AISI309 austenitic stainless steel composition to modify their structure and pitting corrosion resistance in 0.1 M HCl. The structural characterization was carried out by X-rays diffraction and optical microscopy. Corrosion behavior was investigated using potentiodynamic tests and electrochemical impedance measurements (EIS .Results showed that vanadium and niobium addition precipitated stable carbides (VC, NbC to chromium carbides’ detriment and improved austenitic stainless steel corrosion resistance.

  1. Current status of the Thai Research Reactor (TRR-1/M1)

    Chueinta, Siripone; Julanan, Mongkol; Charncanchee, Decharchai

    2006-01-01

    The first Thai Research Reactor, TRR-1 went critical on 27 October 1962 at the maximum power of 1 MW. It was located at Office of Atoms for Peace (OAP) in Bangkok. Since then, TRR-1 was continuously operated and eventually shut down in 1975. Plate type, high-enriched uranium (HEU) and U 3 O 8 A1 cladding were used as the reactor fuel. Light water was used as moderator and coolant as well. In 1975, because of the problem from fuel supplier and also to supporting the Treaty of Non Proliferation of Nuclear Weapon or NPT, TRR-1 was shut down for modification. The reactor core and control system were disassembled and replaced by TRIGA Mark III. A new core was a hexagonal core shape designed by General Atomics (GA). Afterwards, TRR-1 was officially renamed to the Thai Research Reactor-1/Modification 1 (TRR-1/M1). TRR-1/M1 is a multipurpose swimming pool type reactor with nominal power of 2 MW. The TRR-1/M1 uses uranium enriched at 20% in U-235 (LEU) and ZrH alloy as fuel. Light water is also used as coolant and moderator. At present, the reactor is operating with core No.14. The reactor has been serving for various kinds of utilization namely, radioisotope production, neutron activation analysis, beam experiments and reactor physics experiments. (author)

  2. McDonald 2.1-m and CRTS Photometry of Eclipsing Polars

    Wells, Natalie; Mason, Paul

    2018-01-01

    We present broadband optical photometry of five polars made using the 2.1-m telescope of McDonald Observatory. Four of the polars are eclipsing (EP Dra, FL Cet, V2301 Oph, and a Catalina Sky Survey (CSS) polar candidate). In addition, a pre-polar (MQ Dra) was observed. Typical integration times were 1-3 seconds with no dead time. At this time resolution, eclipse structure can be seen in both one- and two-pole accretors. McDonald 2.1-m data over several years is phased together with CSS photometry covering up to 7 years, in search of indications of period variation. Combining the high-resolution, high-speed photometry obtained using the ProEm camera on the McDonald 2.1-m with the sparse, but high-quality multi-year baseline photometry of the CSS places strong constraints on the time variability of the eclipse periods in these binary systems. In most cases, eclipse variations do not perfectly fit a linear ephemeris. We investigate the source of variations using standard O-C diagram techniques and period search algorithms.

  3. Efecto sobre la mejora y retención de la fuerza de un programa de entrenamiento de fuerza con cargas concentradas en sujetos no entrenados. Effect on the strength improvement and retention during a training program with concentrated loads in non trained subjects.

    Navarro Valdivielso, Fernando

    2007-04-01

    Full Text Available ResumenEn este estudio se ha analizado la mejora y retención de la fuerza en 34 sujetos no entrenados, distribuidos de forma aleatoria en un grupo experimental (GE (n=17 que efectuó un programa de entrenamiento para la mejora de la misma de 9 semanas de duración, realizando 4 sesiones consecutivas de entrenamiento semanal, y un grupo control (GC (n=17 que no llevó a cabo ningún entrenamiento. Se tomaron mediciones del peso máximo elevado en 1RM, la fuerza máxima, y la fuerza media total, con el sistema de medición de fuerzas dinámicas Isocontrol 3.6, en el ejercicio de squat (SQ, antes (PRE-, en la mitad (MED- y al final del tratamiento (POST 1, así como tras 1 (POST 2 y 2 meses (POST 3 de la finalización mismo. En el GE, las ganancias de fuerza fueron altamente significativas (pAbstractIn this study has analyzed the improvement and retention of strength in 34 nontrained subjects, randomized in an experimental group(GE (n=17 who realized a strength training program during 9 weeks, making 4 consecutive sessions of weekly training, and a control group (GC (n=17 who did not realized any training. The 1 repetition maximum (1RM, maximum strength, total mean strength, were measured with ISOCONTROL 3.6. device in squat (SQ. The measured were done before (PRE-, in the middle (MED-, at the end of the treatment (POST 1, as well as after 1 and 2 months of the conclusion of the same one. In the experimental group, the strength gains were highly significant as much in the middle (19%, as at the end of the training program (35%, and even after 2 months of the conclusion of the same one (40%. In the GC significant changes did not take place. In conclusion, after 9 weeks of strength training, can be obtained improvements of same highly significant using concentrated loads in nontrained subjects, and they are possible to be continued reaching greater gains during at least other 8 weeks after more finalized the training.

  4. La fuerza de los lazos: una exploración teórica y empírica de sus múltiples significados

    Irene Cruz Gómez

    2013-01-01

    Full Text Available La fuerza del vínculo es una de las características recurrentemente estudiadas en las redes personales. Es un dato aparentemente sencillo de generar, con una potencial capacidad predictiva sobre los intercambios dentro de la relación y de la posición del contacto dentro de la red. Sin embargo, la gran diversidad de indicadores que se emplean en la literatura para medir esta fuerza del vínculo da fe de la vaguedad en la definición del concepto y las consecuentes dificultades para operativizarlo, dando lugar a resultados ambivalentes en su observación empírica. Con este trabajo de revisión teórica, metodológica y empírica se pre- tende ofrecer una base sobre la cual contribuir a la delimitación del concepto. Se propone una dimensionalización teórica de la noción, distinguiendo sus aspectos expresivos, sociales y estructurales, y a continuación se compara el comportamiento de diversos indicadores de las distintas dimensiones empleando una muestra de 441 redes personales y 13.230 relaciones provenientes de una encuesta realizada en Cataluña entre 2009 y 2010.

  5. La fuerza de los vínculos débiles en la inserción laboral de los migrantes nicaragüenses

    Borge, Dalia

    2005-07-01

    Full Text Available Se trata de un artículo que pretende dar a conocer la fuerza que tienen los vínculos débiles simulados como vínculos fuertes en la red social de migrantes trabajadores de nicaragüenses en Costa Rica. Para el análisis se observa el fenómeno de la migración desde el capital social de Bourdieu (2001 y Coleman (1988, así como de los análisis realizados por Granovetter (2000 en cuanto a la fuerza de los vínculos débiles. Mediante la realización de treinta entrevistas a los integrantes de una red que se denominó como agrícola, se logra observar que la recomendación que un actor de la red hace para que un tercero ingrese a un trabajo remunerado, se hace simulando que se conoce y que se da fe sobre las habilidades del futuro trabajador. Este simulacro del vínculo débil como fuerte, es lo que finalmente permite el éxito en la inserción laboral del migrante.

  6. ANÁLISIS COMPARATIVO DE LOS EFECTOS AGUDOS DE SESIONES DE ENTRENAMIENTO DE FUERZA CON CARGAS DEL 90 Y 30% 1 RM.

    Jorge Dopico Calvo

    2010-10-01

    Full Text Available En una medición inicial (Pretest se obtuvo la 1RM de 23 sujetos masculinos en el ejercicio press banca, así como la potencia y fuerza media aplicada al 90 y 30% de 1RM (PMED90, FMED90, PMED30, FMED 30. Posteriormente 11 sujetos (Gr90 llevaron a cabo 2 sesiones de entrenamiento con cargas del 90%, mientras los 12 sujetos restantes (Gr30 lo hacían con cargas del 30%. Inmediatamente finalizada cada una de las sesiones se valoraba nuevamente PMED90, FMED90, PMED30, FMED30. Una semana después de la finalización de los entrenamientos se efectuó un Postest. Los resultados mostraron una mejora estadísticamente significativa del rendimiento de Gr30 al final de cada una de las sesiones de entrenamiento, respecto a Pretest y Postest, con el 90% de 1RM, mientras que Gr90 obtuvo mejoras significativas con el 30% respecto a Pretest, pero no respecto a Postest.
    PALABRAS CLAVE: fuerza, potencia, medición, efecto agudo.

  7. APLICACIÓN DE LA PLATAFORMA DE FUERZAS COMO RECURSO PARA LA OPTIMIZACIÓN DE LA TÉCNICA EN ACROSPORT

    A. Bote García

    2010-10-01

    Full Text Available

     

    El objetivo principal del presente estudio ha sido conocer la aplicación de fuerzas en el suelodel portor en un lanzamiento en acrosport, con el fin de determinar el nivel de rendimiento.Para ello, se plantearon dos situaciones experimentales que permitieron el estudio cinéticode la acción del lanzador. En la primera, una pareja de acrosport, realizó 30 repeticiones deun gesto de lanzamiento. La variabilidad de los resultados encontrados en la aplicación defuerza llevo a plantear otra situación experimental únicamente con el portor con el fin dedeterminar si dicha variabilidad se podía explicar por su actuación. Los resultados hanposibilitado describir el patrón del lanzamiento en términos mecánicos, y demostrar laeficacia de los estudios biomecánicos en la aplicación de corrección de errores técnicos.

    PALABRAS CLAVE: Acrosport, plataforma de fuerza, variabilidad en la ejecución

  8. INSTRUMENTOS NACIONALES E INTERNACIONALES DE PROTECCION A LOS DERECHOS HUMANOS Y AL D.I.H. VIOLADOS POR LAS FUERZAS MILITARES CON EL DELITO DE EJECUCIONES EXTRAJUDICIALES EN COLOMBIA

    Gonzalez Suescun, Leonardo; Mariño, Martha; Velasquez Villamarin, Carlos Antonio

    2010-01-01

    Uno de los fenómenos que durante años se ha presentado en el país y que en los últimos meses ha cobrado fuerza, son las ejecuciones extrajudiciales ya que dicha práctica evidencia violaciones concretas y directas de Derechos Humanos e infracciones al Derecho Internacional Humanitario. Los falsos positivos son un extremo del espectro de infracciones al Derecho Internacional Humanitario y violaciones a los Derechos Humanos por parte de la Fuerza Pública. Los falsos positivos, es preciso in...

  9. Relación entre la fuerza y la electromiografía (EMG) del vasto interno del cuádriceps, en movimientos de media sentadilla con carga

    García-Fogeda, A.; Usach Minguillón, R.

    2008-01-01

    El objetivo del presente trabajo es analizar la relación existente entre la señal electromiográfica (EMG) del vasto interno del cuadriceps y los registros de fuerza vertical en una plataforma de fuerzas, durante un movimiento repetitivo y continuo de media sentadilla, con una carga del peso corporal (PC). Para cuantificar dicha relación se ha estimado el coeficiente de correlación bivariada de Pearson con el software SPSS v.11 tanto en la totalidad del movimiento, como por separado en fases e...

  10. Efectos del ejercicio aeróbico interválico, combinado con entrenamiento de fuerza y de la restricción calórica, sobre la composición corporal de ratas obesas

    I. Coll-Risco; D. Camiletti-Moirón; D.J. Tirado; E. Nebot; A. Andrade; R. Martínez; G. Kapravelou; J.M. Porres; P. Aranda; V.A. Aparicio

    2017-01-01

    Objetivo: Investigar los efectos de un programa de ejercicio aeróbico interválico, combinado con entrenamiento de fuerza, y de la restricción calórica, sobre el peso y la composición corporal de ratas genéticamente obesas. Método: Un total de 32 ratas genéticamente obesas fueron divididas aleatoriamente en dos grupos (n = 16) con o sin ejercicio aeróbico interválico combinado con entrenamiento de fuerza. A su vez, cada grupo, con o sin ejercicio aeróbico interválico combinado con entrenami...

  11. Efectos del ejercicio aeróbico interválico, combinado con entrenamiento de fuerza y de la restricción calórica, sobre la composición corporal de ratas obesas

    Coll-Risco, I.; Camiletti-Moirón, D.; Tirado, D.J.; Nebot, E.; Andrade, A.; Martínez, R.; Kapravelou, G.; Porres, J.M.; Aranda, P.; Aparicio, V.A.

    2017-01-01

    Resumen Objetivo: Investigar los efectos de un programa de ejercicio aeróbico interválico, combinado con entrenamiento de fuerza, y de la restricción calórica, sobre el peso y la composición corporal de ratas genéticamente obesas. Método: Un total de 32 ratas genéticamente obesas fueron divididas aleatoriamente en dos grupos (n = 16) con o sin ejercicio aeróbico interválico combinado con entrenamiento de fuerza. A su vez, cada grupo, con o sin ejercicio aeróbico interválico combinado con en...

  12. Análisis de la disminución de fuerza de agarre en la mano por uso de guante en actividades de aseo y cafetería

    Zea, Christian Ricardo; Caro, Martha Patricia; Quintana, Leonardo Augusto

    2016-01-01

    En la literatura existen estudios relacionados con la disminución de fuerza por el uso de guante en actividades de riesgo como aviación o mantenimiento eléctrico. Sin embargo, no ha sido estudiado este factor en tareas de aseo y cafetería, en las que el uso de guantes es necesario. Objetivos: responder a la pregunta sobre la existencia de efecto en la fuerza de agarre por el uso de guante y postura en esta población que se caracteriza por su vulnerabilidad e incidencia en lesiones musculoesqu...

  13. Análisis de la disminución de fuerza de agarre en la mano por uso de guantes en actividades de aseo y cafetería

    Zea, Christian Ricardo; Caro, Martha Patricia; Quintana, Leonardo Augusto

    2016-01-01

    Introducción: existen en la literatura estudios relacionados con la disminución de fuerza por el uso de guantes en actividades de riesgo, como aviación o mantenimiento eléctrico. Sin embargo, no ha sido estudiado este factor en tareas de aseo y cafetería, donde el uso de guantes es necesario. Se pretende entonces responder a la pregunta, si existe efecto en la fuerza de agarre por el uso de guantes y postura en esta población que se caracteriza por su vulnerabilidad e incidencia en lesiones m...

  14. HQET at order 1/m. Pt. 2. Spectroscopy in the quenched approximation

    Blossier, Benoit; Della Morte, Michele; Garron, Nicolas; Edinburgh Univ.; Hippel, Georg von; DESY, Zeuthen; Mendes, Tereza; Sao Paulo Univ., Sao Carlos; Simma, Hubert; Sommer, Rainer

    2010-06-01

    Using Heavy Quark Effective Theory with non-perturbatively determined parameters in a quenched lattice calculation, we evaluate the splittings between the ground state and the first two radially excited states of the B s system at static order. We also determine the splitting between first excited and ground state, and between the B s * and B s ground states to order 1/m b . The Generalized Eigenvalue Problem and the use of all-to-all propagators are important ingredients of our approach. (orig.)

  15. HQET at order 1/m. Pt. 2. Spectroscopy in the quenched approximation

    Blossier, Benoit [CNRS et Paris-Sud XI Univ., Orsay (France). Lab. de Physique Theorique; Della Morte, Michele [Mainz Univ. (Germany). Inst. fuer Kernphysik; Garron, Nicolas [Universidad Autonoma de Madrid (Spain). Dept. de Fisica Teorica e Inst. de Fisica Teorica IFT-UAM/CSIC; Edinburgh Univ. (United Kingdom). SUPA, School of Physics; Hippel, Georg von [Mainz Univ. (Germany). Inst. fuer Kernphysik; DESY, Zeuthen (Germany). NIC; Mendes, Tereza [DESY, Zeuthen (Germany). NIC; Sao Paulo Univ., Sao Carlos (Brazil). IFSC; Simma, Hubert; Sommer, Rainer [DESY, Zeuthen (Germany). NIC

    2010-06-15

    Using Heavy Quark Effective Theory with non-perturbatively determined parameters in a quenched lattice calculation, we evaluate the splittings between the ground state and the first two radially excited states of the B{sub s} system at static order. We also determine the splitting between first excited and ground state, and between the B{sub s}{sup *} and B{sub s} ground states to order 1/m{sub b}. The Generalized Eigenvalue Problem and the use of all-to-all propagators are important ingredients of our approach. (orig.)

  16. Determination of curve 1/M profile as a function of control rod bank position

    Pereira, Valmir; Martinez, Aquilino Senra; Silva, Fernando Carvalho da

    2002-01-01

    Determination of the subcritical multiplication curve profile (1/M) as a function of control rod bank position is of paramount importance to the development of a system which allows to foresee and also anticipate determination of criticality of a PWR reactor core. This work aims at determining this profile. For that, the 3D- two group-diffusion equations for a subcritical PWR reactor core with external neutron source is solved for different control rod bank positions. Results obtained are compared with the results from the corresponding eigenvalue problem, in order to verify how the external neutron source interferes with the reactor criticality search. (author)

  17. Plasma behavior with molecular beam injection in the HL-1m tokamak

    Yao Lianghua; Tang Nianyi; Cui Zhengying; Xu Deming; Deng Zhongchao; Ding Xuantong; Luo Junlin; Dong Jiafu; Guo Gancheng; Yang Shikun; Cui Chenghe; Xiao Zhenggui; Liu Dequan; Chen Xiaoping; Yan Longwen; Yan Donghai; Wang Enyao; Deng Xiwen

    1999-01-01

    The authors report effect of the new fueling method of high speed molecular beam injection on Tokamak confinement improvement. The present method is an improvement of conventional gas puffing, with performance comparable to the small pellet injection in HL-1M and also to the slow pellet in ASDEX. The fact that a shallower fueling can lead to similar confinement improvement as a deep one suggests that there may exist a critical position in a Tokamak plasma such that any kind of fueling will have a better confinement as long as it can give rise to density peaking at the critical position

  18. Results of heater induced quenches on a 1-m SSC model dipole

    Hassenzahl, W.V.

    1985-10-01

    This report describes the results of a series of heater induced quenches on the 1-m long SSC model dipole D-12C-7 constructed at LBL. Test results of the following types are described: quench propagation velocities - axial; quench propagation velocities - transverse; and rate of temperature rise in the conductor. The primary purpose of these tests was to measure quench velocities at a variety of locations and for several currents/fields which can be used to refine the quench predictions for longer magnets. Because of limited data in the low field region of this magnet, it is recommended that it be retested with additional voltage taps. 20 figs., 6 tabs

  19. Scaling law of runaway electrons in the HL-1M tokamak

    Zheng Yongzhen

    2005-01-01

    Runaway confinement time in ohmic and additionally heated tokamak plasmas presents an anomalous behavior in comparison with theoretical predictions based on neoclassical models. A one-dimensional numerical including generation and loss effects for runaway electrons is used to deduce the dependence of runaway energy ε τ on runaway confinement time. The simulation results are presented in the form of a scaling law for ε τ on plasma parameters. The scaling of ε τ and therefore the runaway confinement time and runaway electron diffusivity has been studied in the HL-1M tokamak, by measuring hard X-ray spectra under different experimental conditions. (authors)

  20. Research on the penetration characteristic of supersonic molecule beam on the HL-1M tokamak

    Dong Jiafu; Luo Junling; Tang Nianyi; Li Wei; Zhong Yunze; Liu Yi; Fu Binzhong; Yao Lianghua; Feng Baibing; Qin Yunwen

    2002-01-01

    In the HL-1M plasma experiments, two refueling ways, the pellet injection and the gas puffing, are usually used. In recent years, a new refueling method, the supersonic molecular beam (SMB) injection, has been developed. In this paper, the penetration characteristics of SMB has been analyzed and researched. The SMB experiments were analyzed with H α emissivity measurement. The H α emissivity distribution in the plasma was calculated from multi-channel chord emission singles by means of the asymmetry Abel inversion method

  1. Noncircular plasma shape analysis in long-pulse current drive experiment in TRIAM-1M

    Minooka, Mayumi; Kawasaki, Shoji; Jotaki, Eriko; Moriyama, Shin-ichi; Nagao, Akihiro; Nakamura, Kazuo; Hiraki, Naoji; Nakamura, Yukio; Itoh, Satoshi

    1991-01-01

    Plasma cross section was noncircularized and the plasma shape was analyzed in order to study the characteristics of the plasma in long-pulse current drive experiments in high-field superconducting tokamak TRIAM-1M. Filament approximation method was adopted, since on-line processing by data processing computer is possible. The experiments of the noncircularization were carried out during 30-to 60-sec discharges. As a result, it became clear that D-shape plasma of elongation ratio 1.4 was maintained stably. By the analysis the internal inductance and poloidal beta were assessed, and so informations about the plasma current profile and internal pressure were obtained. (author)

  2. Benzimidazole and its derivatives as corrosion inhibitors for mild steel in 1M HCl solution

    Aljourani, J.; Raeissi, K.; Golozar, M.A.

    2009-01-01

    In this paper, the inhibition ability of benzimidazole and its derivatives against the corrosion of mild steel in 1M HCl solution was studied. The change of impedance parameters observed by variation of inhibitors concentration within the range of 50-250 ppm was an indication of their adsorption. The thermodynamic adsorption parameters proposed that these inhibitors retard both cathodic and anodic processes through physical adsorption and blocking the active corrosion sites. The adsorption of these compounds obeyed the Langmuir's adsorption isotherm. The inhibition efficiency was increased with inhibitor concentration in the order of 2-mercaptobenzimidazole > 2-methylbenzimidazole > benzimidazole, which is in accordance with the variation of apparent activation energy of corrosion.

  3. Ionic conductivity in irradiated KCL; Conductiviad ionica de KCL irradiado

    Vignolo Rubio, J

    1979-07-01

    The ionic conductivity of X and gamma irradiated KCL single crystals has been studied between room temperature and 600 degree centigree. the radiation induced damage resulting in a decrease of the conductivity heals by thermal annealing in two steps which are at about 350 and 550 degree centigree respectively. It has been found that the radiation induced colour centres are not involved in the observed decrease of the ionic conductivity. However. It has been observed that the effects of quenching and plastic deformation on the conductivity of the samples are very similar to the effect induced by irradiation. It is suggested that, samples radiation induced dislocation loops might cause the ionic conductivity decrease observed in irradiated samples. (Author)

  4. Quintinite-1 M from the Mariinsky Deposit, Ural Emerald Mines, Central Urals, Russia

    Zhitova, E. S.; Popov, M. P.; Krivovichev, S. V.; Zaitsev, A. N.; Vlasenko, N. S.

    2017-12-01

    The paper describes the first finding of quintinite [Mg4Al2(OH)12][(CO3)(H2O)3] at the Mariinsky deposit in the Central Urals, Russia. The mineral occurs as white tabular crystals in cavities within altered gabbro in association with prehnite, calcite, and a chlorite-group mineral. Quintinite is the probable result of late hydrothermal alteration of primary mafic and ultramafic rocks hosting emerald-bearing glimmerite. According to electron microprobe data, the Mg: Al ratio is 2: 1. IR spectroscopy has revealed hydroxyl and carbonate groups and H2O molecules in the mineral. According to single crystal XRD data, quintinite is monoclinic, space group C2/ m, a =5.233(1), b = 9.051(2), c = 7.711(2) Å, β = 103.09(3)°, V = 355.7(2) Å3. Based on structure refinement, the polytype of quintinite should be denoted as 1M. This is the third approved occurrence of quintinite-1M in the world after the Kovdor complex and Bazhenovsky chrysotile-asbestos deposit.

  5. Snake perturbations during pellet injection and LHCD in the HL-1M tokamak

    Liu Yi; Qiu Xiaoming; Dong Yunbo; Guo Gangcheng; Xiao Zhengui; Zhong Yunzhe; Zheng Yinjia; Fu Bingzhong; Dong Jiafu; Liu Yong; Wang Enyao

    2004-01-01

    Excitation of snake perturbations has been observed in the core region of pellet-fuelled HL-1M plasmas when the pellets cross the surface with a q value of 1. It is observed that the snake oscillations have an m = 1, n = 1 helicity with quite a long lifetime. A detailed comparison has been made between the locations of the q = 1 surface and the snake oscillation. Through measurements of the plasma q-profile by means of multi-exposures with a CCD camera during pellet ablation, and investigation of the pellet ablation process, possible mechanisms for the formation of the snake oscillation are discussed. In addition, a large, long-lived snake-like oscillation is frequently observed in lower-hybrid current driven (LHCD) discharge in which the sawtooth has been stabilized early in the discharge. There is evidence that such a perturbation is due to impurity accumulation during sawtooth-stabilization, and good performance with peaking profiles after LHCD is limited by magnetohydrodynamic instabilities including sawtooth and snake activities in HL-1M plasmas

  6. Camera calibration strategy of the SST-1M prototype of the Cherenokov Telescope Array

    Prandini, E; Lyard, E.; Schioppa, E. jr.; Neronov, A.; Bilnik, W.; Błocki, J.; Bogacz, L.; Bulik, T.; Cadoux, F.; Christov, A.; Curyło, M.; della Volpe, D.; Dyrda, M.; Favre, Y.; Frankowski, A.; Grudnik, Ł.; Grudzińska, M.; Idźkowski, B.; Jamrozy, M.; Janiak, M.; Kasperek, J.; Lalik, K.; Mach, E.; Mandat, D.; Marszałek, A.; Michałowski, J.; Moderski, R.; Montaruli, T.; Niemiec, J.; Ostrowski, M.; Paśko, P.; Pech, M.; Porcelli, A.; Rameez, M.; Rajda, P.; Schovanek, P.; Seweryn, K.; Skowron, K.; Sliusar, V.; Sowiński, M.; Stawarz, Ł.; Stodulska, M.; Stodulski, M.; Toscano, S.; Pujadas, I. Troyano; Walter, R.; Więcek, M.; Zagdański, A.; Ziętara, K.; Żychowski, P.

    2015-01-01

    The SST-1M telescope is one of the prototypes under construction proposed to be part of the future Cherenkov Telescope Array. It uses a standard Davis-Cotton design for the optics and telescope structure, with a dish diameter of 4 meters and a large field-of-view of 9 degrees. The innovative camera design is composed of a photo-detection plane with 1296 pixels including entrance window, light concentrators, Silicon Photomultipliers (SiPMs), and pre-amplifier stages together with a fully digital readout and trigger electronics, DigiCam. In this contribution we give a general description of the analysis chain designed for the SST-1M prototype. In particular we focus on the calibration strategy used to convert the SiPM signals registered by DigiCam to the quantities needed for Cherenkov image analysis. The calibration is based on an online feedback system to stabilize the gain of the SiPMs, as well as dedicated events (dark count, pedestal, and light flasher events) to be taken during the normal operation of the...

  7. Development of Neutron Imaging System for Neutron Tomography at Thai Research Reactor TRR-1/M1

    Wonglee, S.; Khaweerat, S.; Channuie, J.; Picha, R.; Liamsuwan, T.; Ratanatongchai, W.

    2017-09-01

    The neutron imaging is a powerful non-destructive technique to investigate the internal structure and provides the information which is different from the conventional X-ray/Gamma radiography. By reconstruction of the obtained 2-dimentional (2D) images from the taken different angle around the specimen, the tomographic image can be obtained and it can provide the information in more detail. The neutron imaging system at Thai Research Reactor TRR-1/M1 of Thailand Institute of Nuclear Technology (Public Organization) has been developed to conduct the neutron tomography since 2014. The primary goal of this work is to serve the investigation of archeological samples, however, this technique can also be applied to various fields, such as investigation of industrial specimen and others. This research paper presents the performance study of a compact neutron camera manufactured by Neutron Optics such as speed and sensitivity. Furthermore, the 3-dimentional (3D) neutron image was successfully reconstructed at the developed neutron imaging system of TRR-1/M1.

  8. Application of PIN diode to soft x-ray measurement in TRIAM-1M

    Ohinata, Hirohiko; Kawasaki, Shoji; Kamitaki, Eriko; Moriyama, Shin-ichi; Nagao, Akihiro; Nakamura, Kazuo; Nakamura, Yukio; Hiraki, Naoji; Itoh, Satoshi.

    1989-01-01

    The soft X-ray in TRIAM-1M is measured with a PIN diode array in an effort to examine the internal MHD structures in tokamak plasma in TRIAM-1M. A magnetic probe is also used to make measurements. Based on these measurements, the region where sawtooth oscilations appears is identified in the Hugill diagram. The safety factor at the plasma surface at the time of the appearance of sawtooth oscillations is found to be larger than that at the time of its disappearance, indicating that the current density distribution becomes steeper with time. The time changes in the distribution of electron density and q-value are roughly calculated from those in the safety factor and inversion radius of sawtooth oscillations to confirm the above results. In low-q discharges, current disruption occurs either through the growth of the m=2/n=1 mode or through the interaction between the m=2/n=1 mode and m=3/n=2 mode. Current disruption in high-density discharges seems to occur through the growth of the m=2/n=1 mode. The rate of growth of sinusoidal oscillations is found to be only slightly dependent on the density. (N.K.)

  9. Hydrogen retention properties of co-deposition under high-density plasmas in TRIAM-1M

    Tokitani, M.; Miyamoto, M.; Tokunaga, K.; Fujiwara, T.; Yoshida, N.; Sakamoto, M.; Zushi, H.; Hanada, K.; TRIAM Group,; Nagata, S.; Tsuchiya, B.

    2007-01-01

    Retention of hydrogen in co-deposits formed under high-density plasma discharge in TRIAM-1M was studied. In order to quantify the retained hydrogen, material probe experiments were performed under the high-density (n at e ∼10 19 m -3 ) discharges. After the exposure to the plasma, the quantitative analysis of deposition, hydrogen retention, and microscopic modification of specimens were performed by means of ion beam analysis and transmission electron microscopy. The co-deposits mainly consisted of Mo. The deposition rate of Mo was about ten times higher than that of the low-density discharge case. The hydrogen concentrations (H/Mo) retained in the co-deposits were 0.06-0.17, which was much higher than that in bulk-Mo and almost equal to the low-density case. These results indicate that as long as the co-deposition layers are continuously formed, strong wall pumping in TRIAM-1M is maintained during the discharges

  10. Eight-shot pellet injector and fueling experiments at the HL-1M tokamak

    Xiao Zhenggui; Li Bo; Li Li

    2001-01-01

    An Eight-shot Pellet Injection (EPI) system has been proposed and developed in collaboration between STU (St. Petersburg State Technical University) of Russia and SWIP. In the EPI, the I n-situ c ondensation technique was used to produce the pellets in eight gun barrels respectively. The nominal pellet size (diameter of 1.0 mm and of 1.4 mm or 1.2 mm) is limited by the gun barrel inner diameter. The pellet length is adjusted by changing the g radient temperature o n the gun barrels and the amounts of filling fuel gas. Pellets are fired at speed range of 200 - 1200 m/s by He propellant with pressure of 2 - 6 MPa and then transferred to HL-1M vessel through an injection line that consists of two set of differential vacuum pumped chambers and guide tube combined with fast valves. In addition, this unit is equipped with diagnostics for pellet velocity and shape measure. The EPI has installed on HL-1M since 1996 for the multi-shot pellet fueling experiments. The typical characteristics including the peaked density profile and improved confinement, the deep penetration and suppression of soft X-ray sawteeth, the variance of rotation and flow of plasma in edge region as well as the photographing of pellet ablation clouds are presented

  11. Oestradiol reduces Liver Receptor Homolog-1 mRNA transcript stability in breast cancer cell lines

    Lazarus, Kyren A.; Zhao, Zhe; Knower, Kevin C.; To, Sarah Q.; Chand, Ashwini L.; Clyne, Colin D.

    2013-01-01

    Highlights: •LRH-1 is an orphan nuclear receptor that regulates tumor proliferation. •In breast cancer, high mRNA expression is associated with ER+ status. •In ER−ve cells, despite very low mRNA, we found abundant LRH-1 protein. •Our data show distinctly different LRH-1 protein isoforms in ER− and ER+ breast cancer cells. •This is due to differences in LRH-1 mRNA and protein stability rates. -- Abstract: The expression of orphan nuclear receptor Liver Receptor Homolog-1 (LRH-1) is elevated in breast cancer and promotes proliferation, migration and invasion in vitro. LRH-1 expression is regulated by oestrogen (E 2 ), with LRH-1 mRNA transcript levels higher in oestrogen receptor α (ERα) positive (ER+) breast cancer cells compared to ER− cells. However, the presence of LRH-1 protein in ER− cells suggests discordance between mRNA transcript levels and protein expression. To understand this, we investigated the impact of mRNA and protein stability in determining LRH-1 protein levels in breast cancer cells. LRH-1 transcript levels were significantly higher in ER+ versus ER− breast cancer cells lines; however LRH-1 protein was expressed at similar levels. We found LRH-1 mRNA and protein was more stable in ER− compared to ER+ cell lines. The tumor-specific LRH-1 variant isoform, LRH-1v4, which is highly responsive to E 2 , showed increased mRNA stability in ER− versus ER+ cells. In addition, in MCF-7 and T47-D cell lines, LRH-1 total mRNA stability was reduced with E 2 treatment, this effect mediated by ERα. Our data demonstrates that in ER− cells, increased mRNA and protein stability contribute to the abundant protein expression levels. Expression and immunolocalisation of LRH-1 in ER− cells as well as ER− tumors suggests a possible role in the development of ER− tumors. The modulation of LRH-1 bioactivity may therefore be beneficial as a treatment option in both ER− and ER+ breast cancer

  12. Oestradiol reduces Liver Receptor Homolog-1 mRNA transcript stability in breast cancer cell lines

    Lazarus, Kyren A. [Cancer Drug Discovery Laboratory, Prince Henry’s Institute of Medical Research, Clayton, Victoria 3168 (Australia); Environmental and Biotechnology Centre, Swinburne University, Hawthorn, Victoria 3122 (Australia); Zhao, Zhe; Knower, Kevin C. [Cancer Drug Discovery Laboratory, Prince Henry’s Institute of Medical Research, Clayton, Victoria 3168 (Australia); To, Sarah Q. [Cancer Drug Discovery Laboratory, Prince Henry’s Institute of Medical Research, Clayton, Victoria 3168 (Australia); Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168 (Australia); Chand, Ashwini L. [Cancer Drug Discovery Laboratory, Prince Henry’s Institute of Medical Research, Clayton, Victoria 3168 (Australia); Clyne, Colin D., E-mail: Colin.clyne@princehenrys.org [Cancer Drug Discovery Laboratory, Prince Henry’s Institute of Medical Research, Clayton, Victoria 3168 (Australia); Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168 (Australia)

    2013-08-30

    Highlights: •LRH-1 is an orphan nuclear receptor that regulates tumor proliferation. •In breast cancer, high mRNA expression is associated with ER+ status. •In ER−ve cells, despite very low mRNA, we found abundant LRH-1 protein. •Our data show distinctly different LRH-1 protein isoforms in ER− and ER+ breast cancer cells. •This is due to differences in LRH-1 mRNA and protein stability rates. -- Abstract: The expression of orphan nuclear receptor Liver Receptor Homolog-1 (LRH-1) is elevated in breast cancer and promotes proliferation, migration and invasion in vitro. LRH-1 expression is regulated by oestrogen (E{sub 2}), with LRH-1 mRNA transcript levels higher in oestrogen receptor α (ERα) positive (ER+) breast cancer cells compared to ER− cells. However, the presence of LRH-1 protein in ER− cells suggests discordance between mRNA transcript levels and protein expression. To understand this, we investigated the impact of mRNA and protein stability in determining LRH-1 protein levels in breast cancer cells. LRH-1 transcript levels were significantly higher in ER+ versus ER− breast cancer cells lines; however LRH-1 protein was expressed at similar levels. We found LRH-1 mRNA and protein was more stable in ER− compared to ER+ cell lines. The tumor-specific LRH-1 variant isoform, LRH-1v4, which is highly responsive to E{sub 2}, showed increased mRNA stability in ER− versus ER+ cells. In addition, in MCF-7 and T47-D cell lines, LRH-1 total mRNA stability was reduced with E{sub 2} treatment, this effect mediated by ERα. Our data demonstrates that in ER− cells, increased mRNA and protein stability contribute to the abundant protein expression levels. Expression and immunolocalisation of LRH-1 in ER− cells as well as ER− tumors suggests a possible role in the development of ER− tumors. The modulation of LRH-1 bioactivity may therefore be beneficial as a treatment option in both ER− and ER+ breast cancer.

  13. Un estudio sobre las investigaciones acerca de las ideas de los estudiantes en fuerza y movimiento A study on researches about students ideas on force and motion

    Silvia Giorgi

    2005-04-01

    Full Text Available Se llevó a cabo un análisis exhaustivo de publicaciones sobre preconcepciones o ideas iniciales referidas al tema "cuerpos en movimiento", también comúnmente denominado "fuerza y movimiento". Se estudiaron los aspectos teóricos, metodológicos y conceptuales involucrados en una muestra de investigaciones consistente en 36 trabajos publicados en revistas especializadas y en libros de distintas procedencias y autores. Los sujetos participantes en las investigaciones abarcan distintos niveles y tipos de instrucción. Los resultados revelan, por un lado la existencia de distintos objetivos, diferentes posturas asumidas por los investigadores con relación a las ideas iniciales, fuentes de datos utilizadas variadas, así como heterogeneidad en los resultados obtenidos y en su interpretación. Por otro lado, del estudio realizado surge que si bien los sujetos no poseen una conceptualización científica de fuerza, en las representaciones que ellos construyen de los fenómenos mecánicos podrían estar involucradas significaciones del término Fuerza asociadas a otras magnitudes físicas tales como cantidad de movimiento y energía. Se concluye en la necesidad de abordar el problema de las preconcepciones desde una nueva perspectiva tanto teórica como metodológica.An exhaustive analysis of publications about human preconceptions or initial ideas in regard to "bodies in movement" was carried out. Theoretical, methodological and conceptual aspects of a sample of 36 works on individuals of diverse levels of instruction and published in journals and books of different origins, were studied. Our findings revealed a great variety of goals as well as of postures assumed by the investigators with respect to preconceptions. Types of data sources as well as results and their interpretation showed also a great dispersion. From another point of view, the results of the present study suggest that although the subjects' conceptualization of force may be wrong

  14. Performance of 1m long/100 mm bore superconducting dipole prototypes for HERA

    Horlitz, G; Wolff, S.

    1983-01-01

    Three 1 m long superconducting dipole prototypes with 100 mm inner coil diameter for the proposed HERA electron-proton storage ring have been built and tested. Main design principles are a two layer coil clamped with stainless steel collars inside a cryostat with warm beam tube and surrounded by a warm iron yoke. All prototypes have been tested without yoke and one of them with yoke. The design induction of 4.73 Tesla at 4.6 K has been easily surpassed up to short sample fields with negligible training. The quench behaviour has been investigated between temperatures of 3.8 K and 5.0 K. The field quality has been found well within the specified limits given by the requirements of the storage ring optics. The reproducibility found in this sample of magnets gives great confidence for the production of dipole prototypes of full length

  15. In situ measurements of erosion and redeposition during long duration discharges on TRIAM-1M

    Sakamoto, M.; Ogawa, M.; Zushi, H.; Higashijima, A.; Nakashima, H.; Kawasaki, S.; Hasegawa, M.; Idei, H.; Hanada, K.; Nakamura, K.; Sato, K.N.

    2007-01-01

    An in situ and real time measurement system of erosion and deposition has been developed, which is based on interference of light on a thin semi-transparent layer of redeposited material on substrate. It has been applied to long duration discharges in TRIAM-1M. The sapphire window is used as substrate. The deposition pattern on the window indicates up down and toroidal asymmetry. In the 5 h 16 min discharge, the thickness of the deposited layer increased monotonically with time and its deposition rate is ∼1.5 x 10 16 Mo m -2 s -1 . In the low density and long duration discharge, the Mo deposition rate on the window depends on the ratio of Mo flux to hydrogen flux

  16. New transition phenomena in a long discharge on TRIAM-1M

    Hanada, K.; Itoh, S.; Nakamura, K.; Zushi, H.; Sakamoto, M.; Jotaki, E.; Hasegawa, M.; Kawasaki, S.; Nakashima, H.; Pan, Y.D.

    2001-01-01

    Abstract Enhancement of current drive (ECD) efficiency mode, which is characterized by the spontaneous increase of current drive efficiency, η CD , from 0.3-0.4x10 19 A/Wm -2 to 0.7-1.0x10 19 A/Wm -2 , is observed in long pure lower hybrid current drive (LHCD) plasmas on TRIAM-1M. The energy confinement time is also improved due to the increase of line averaged electron density, ion and electron temperatures. The current drive efficiency is proportional to the electron density. The transition to ECD mode occurs at a critical density, which slightly depends on the refractive index to the toroidal direction, N parallel of the injected wave. (author)

  17. The MCNP Simulation of a PGNAA System at TRR-1/M1

    Sangaroon, S.; Ratanatongchai, W.; Picha, R.; Khaweerat, S.; Channuie, J.

    2017-06-01

    The prompt-gamma neutron activation analysis system (PGNAA) has been installed at Thai Research Reactor-1/Modified 1 (TRR-1/M1) since 1999. The purpose of the system is for elemental and isotopic analyses. The system mainly consists of a series of the moderator and collimator, neutron and gamma-ray shielding and the HPGe detector. In this work, the condition of the system is carried out based on the Monte Carlo method using Monte Carlo N-Particle transport code and the experiment. The flux ratios (Φthermal/Φepithermal and Φthermal/Φfast) and thermal neutron flux have been obtained. The simulated prompt gamma rays of the Portland cement sample have been carried out. The simulation provides significant contribution in upgrading the PGNAA station to be available in various applications.

  18. Plasma-induced surface degradation in 304 stainless steel used for TRIAM-1M limiter

    Tsukuda, N.; Kuramoto, E.; Tokunaga, K.; Muroga, T.; Yoshida, N.; Itoh, S.

    1994-01-01

    Surface degradation in a 304 stainless steel limiter of TRIAM-1M by long-pulse discharge during long period operation has been examined by means of X-ray diffraction, scanning electron microscopy and dynamical microindentation tests. Particular exfoliation and hardening of the surface of the electron drift side were observed. These result from the formation of α prime martensite induced by hydrogen in the plasma. The stability of the martensitic phase has been studied by annealing experiments on the cathodically hydrogen charged 316 stainless steel by X-ray diffraction. Both ε and α prime martensites were formed by 22 h cathodic charging. The former reverts to γ-phase and/or converts to α prime martensite below 723 K and the latter reverts to γ-phase below 923 K, repectively. ((orig.))

  19. Qualifying tests for TRIAM-1M superconducting toroidal magnetic field coil

    Nakanura, Yukio; Hiraki, Naoji; Nakamura, Kazuo; Tanaka, Masayoshi; Nagao, Akihiro; Kawasaki, Shoji; Itoh, Satoshi

    1984-09-01

    In the strong toroidal magnetic field experimental facility ''TRIAM-1M'' currently under construction, construction of the superconducting toroidal magnetic field coil and the following qualifying tests conducted on the full-scale superconducting toroidal magnetic field coil actually fabricated are described: (1) coil excitation test, (2) superconducting stability test, (3) external magnetic field application test, and (4) high-speed excitation test. On the basis of these test results, stability was evaluated of the superconducting coil being operated in the tokamak device. In normal tokamak operation, there occurs no normal conduction transition. At the time of plasma disruption, though this transition takes place in part of the coil, the superconducting state is immediately restored. By its electromagnetic force analysis, the superconducting coil is also stable in structure.

  20. Optimize of Deuteron Current of 150 keV, 1 mA Neutron Generator

    Sri Sulamdari; Djasiman

    2003-01-01

    It has been characterized a 150 keV/1 mA Neutron Generator. It has been used some local components, except accelerator tube and vacuum system. To produce neutron, it has been used a deuterium gas bombarded into tritium target through reaction 3 H(d,n) 4 He. For preliminary experiment, we used the air as an ion source. The beam current of deuteron as a function of process parameters are presented in this paper. It's found that the optimum beam current of deuteron was 1000 μA, and this conditions was achieved at accelerations voltage 30 kV, extraction voltage 5 kV, guide voltage -11 kV and vacuum 10 -6 mbar. (author)

  1. Enhanced M1/M2 macrophage ratio promotes orthodontic root resorption.

    He, D; Kou, X; Luo, Q; Yang, R; Liu, D; Wang, X; Song, Y; Cao, H; Zeng, M; Gan, Y; Zhou, Y

    2015-01-01

    Mechanical force-induced orthodontic root resorption is a major clinical challenge in orthodontic treatment. Macrophages play an important role in orthodontic root resorption, but the underlying mechanism remains unclear. In this study, we examined the mechanism by which the ratio of M1 to M2 macrophage polarization affects root resorption during orthodontic tooth movement. Root resorption occurred when nickel-titanium coil springs were applied on the upper first molars of rats for 3 to 14 d. Positively stained odontoclasts or osteoclasts with tartrate-resistant acid phosphatase were found in resorption areas. Meanwhile, M1-like macrophages positive for CD68 and inducible nitric oxide synthase (iNOS) persistently accumulated on the compression side of periodontal tissues. In addition, the expressions of the M1 activator interferon-γ and the M1-associated pro-inflammatory cytokine tumor necrosis factor (TNF)-α were upregulated on the compression side of periodontal tissues. When the coil springs were removed at the 14th day after orthodontic force application, root resorption was partially rescued. The number of CD68(+)CD163(+) M2-like macrophages gradually increased on the compression side of periodontal tissues. The levels of M2 activator interleukin (IL)-4 and the M2-associated anti-inflammatory cytokine IL-10 also increased. Systemic injection of the TNF-α inhibitor etanercept or IL-4 attenuated the severity of root resorption and decreased the ratio of M1 to M2 macrophages. These data imply that the balance between M1 and M2 macrophages affects orthodontic root resorption. Root resorption was aggravated by an enhanced M1/M2 ratio but was partially rescued by a reduced M1/M2 ratio. © International & American Associations for Dental Research 2014.

  2. Inhibiting effects of imidazole on copper corrosion in 1 M HNO3 solution

    Lee, Woo-Jin

    2003-01-01

    The present work deals with the inhibiting effects of imidazole on the pure copper (Cu) corrosion in 1 M HNO 3 solution analysing potentiodynamic polarisation curves, potentiostatic anodic current transient, AC impedance spectra and X-ray photoelectron spectra (XPS). By adding imidazole to HNO 3 solution, the polarisation curves showed decrease in the corrosion current and the cathodic current, suggesting that imidazole acts as an effective cathodic inhibitor to Cu corrosion. From the measured anodic current transients, it is inferred that the protective Cu-imidazole complex film is simultaneously formed with the Cu oxide in the presence of imidazole during the early stage of the anodic polarisation. Analysis of the AC impedance spectra revealed that the values of the charge transfer resistance R ct obtained in imidazole-containing HNO 3 solution were greater than that value in imidazole-free one and at the same time steadily increased with immersion time to the constant value. Contrarily, the capacitance value was abruptly lowered from the double layer capacitance C dl to the complex film capacitance C cf in the progress of immersion time. Furthermore, the Warburg coefficient σ value for the ion diffusion through the complex film was observed to increase with immersion time. This means that the Cu(N-OH) complex film becomes thicker during immersion in the HNO 3 solution with imidazole through the inward growth of the N-rich outer layer to the O-rich inner layer, as well validated by XPS. Based upon the experimental results, it is suggested that the Cu corrosion in 1 M HNO 3 solution is efficiently inhibited with the addition of imidazole by retarding both the charge transfer on cathodic sites of the Cu surface in the early stage of immersion time and the subsequent ion diffusion through the steadily growing complex film

  3. Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces cell death

    Ejeskär, Katarina; Krona, Cecilia; Carén, Helena; Zaibak, Faten; Li, Lingli; Martinsson, Tommy; Ioannou, Panayiotis A

    2005-01-01

    Neuroblastoma is a solid tumour of childhood often with an unfavourable outcome. One common genetic feature in aggressive tumours is 1p-deletion. The α-enolase (ENO1) gene is located in chromosome region 1p36.2, within the common region of deletion in neuroblastoma. One alternative translated product of the ENO1 gene, known as MBP-1, acts as a negative regulator of the c-myc oncogene, making the ENO1 gene a candidate as a tumour suppressor gene. Methods used in this study are transfection of cDNA-vectors and in vitro transcribed mRNA, cell growth assay, TUNEL-assay, real-time RT-PCR (TaqMan) for expression studies, genomic sequencing and DHPLC for mutation detection. Here we demonstrate that transfection of ENO1 cDNA into 1p-deleted neuroblastoma cell lines causes' reduced number of viable cells over time compared to a negative control and that it induces apoptosis. Interestingly, a similar but much stronger dose-dependent reduction of cell growth was observed by transfection of in vitro transcribed ENO1 mRNA into neuroblastoma cells. These effects could also be shown in non-neuroblastoma cells (293-cells), indicating ENO1 to have general tumour suppressor activity. Expression of ENO1 is detectable in primary neuroblastomas of all different stages and no difference in the level of expression can be detected between 1p-deleted and 1p-intact tumour samples. Although small numbers (11 primary neuroblastomas), there is some evidence that Stage 4 tumours has a lower level of ENO1-mRNA than Stage 2 tumours (p = 0.01). However, mutation screening of 44 primary neuroblastomas of all different stages, failed to detect any mutations. Our studies indicate that ENO1 has tumour suppressor activity and that high level of ENO1 expression has growth inhibitory effects

  4. Efectos del ejercicio aeróbico interválico, combinado con entrenamiento de fuerza y de la restricción calórica, sobre la composición corporal de ratas obesas

    I. Coll-Risco

    2017-03-01

    Conclusiones: Tanto el programa de ejercicio aeróbico interválico, combinado con entrenamiento de fuerza desarrollado, como la restricción calórica, fueron eficaces, mejorando la composición corporal de ratas obesas, pero el ejercicio lo hizo en mayor magnitud.

  5. Study of the efficiency of two strength program training in the Climbing’s yield Estudio de la eficacia de dos programas de entrenamiento de la fuerza en el rendimiento de la escalada deportiva

    S. Sedano

    2010-09-01

    Full Text Available The main aim of the current study was to determine the effectiveness of two strength training for climbing. 30 healthy men participated in the present study, and they were randomly divided into three groups: control group (GC (n=10, maximal strength training group (GFM and endurance-strength training group (GFR. The three groups trained three days per week, GC trained always in wall, but GFM and GFR changed one of them for a training session in the gym. The program lasted 10 weeks and we assesed different kinds of variables before and after the training: physical conditioning variables and hand-grip strength after climbing. We found significant differences in the three groups analysed. GFR obtained the best results according to climbing demands and GFM also obtained significant differences but not as specific as GFR. It could be said that endurance-strength training is the best for climbing.

    Key Words:Climbing, training, maximal strength, endurance-strength.

    El objetivo principal de este trabajo es estudiar la efectividad de dos programas de entrenamiento sobre algunos aspectos relacionados con las demandas específicas para el rendimiento en la escalada. Para ello se han utilizado tres grupos de sujetos: grupo control (GC (n=10 y dos grupos de entrenamiento, uno de fuerza máxima (GFM (n=10 y otro de fuerza resistencia (GFR (n=10, todos ellos con ligera experiencia en la práctica de la escalada. Los grupos entrenaron tres días a la semana, GC en rocódromo y GFM y GFR cambiaron un día de trabajo en rocódromo por uno en el gimnasio. Antes y después del entrenamiento se realizaron diferentes pruebas de valoración de la condición física y de factores específicos de escalada, (pre-test; post-test. En sujetos con poca experiencia los tres tipos de entrenamiento producen mejoras, siendo el trabajo de fuerza-resistencia, el que

  6. Ideas previas sobre carga, fuerza y campo eléctrico en estudiantes universitarios. Consideraciones para su superación

    Marianela Nava

    2008-05-01

    Full Text Available El presente trabajo trata sobre el valor didáctico de las ideas previas de los estudiantes para la construcción de nuevos saberes, que lo posibiliten para dar explicaciones acordes con el conocimiento científico. Luego del análisis de los datos, se plantea el diseño de situaciones didácticas, fundamentadas en Posner et al, Ausubel, Amestoy, Alonso et al, que permitan promover la construcción de conceptos, aplicable a diversos campos. El estudio se encuentra enmarcado en un paradigma cuali-cuantitativo, a nivel descriptivo. Una conclusión importante es que las nociones sobre campo eléctrico, resultaron más deficientes que las de carga, pero menos que las de fuerza eléctrica, siendo necesario fomentar la construcción de conceptos científicos en los estudiantes universitarios.

  7. Análisis de la fuerza isométrica en trampolinistas españoles de distintas categorías competitivas

    Gómez-Landero Rodríguez, Luis Arturo; López Bedoya, Jesús; Vernetta Santana, Mercedes; Marina Evrad, Michel

    2012-01-01

    Introducción: Debido a la ausencia de trabajos que describan y analicen el perfil de fuerza isométrica en Trampolín y su relación con el rendimiento deportivo, se plantea un estudio transversal, comparativo y correlacional en esta línea con trampolinistas españoles. Método: Muestra compuesta por 60 trampolinistas de élite nacional, agrupados por categoría competitiva en 4 grupos: 1) Sub-15 masculino (n = 23; 11,95 ± 1,79 años), 2) Sub-15 femenino (n = 9; 11,44 ± 1,23 años), 3) Absoluto mascul...

  8. Análisis de la fuerza isométrica en trampolinistas españoles de distintas categorías competitivas

    Luis Arturo Gómez-Landero Rodríguez; Jesús López Bedoya; Mercedes Vernetta Santana; Michel Marina Evrad

    2015-01-01

    Introducción: Debido a la ausencia de trabajos que describan y analicen el perfil de fuerza isométrica en Trampolín y su relación con el rendimiento deportivo, se plantea un estudio transversal, comparativo y correlacional en esta línea con trampolinistas españoles. Método: Muestra compuesta por 60 trampolinistas de élite nacional, agrupados por categoría competitiva en 4 grupos: 1) Sub-15 masculino (n = 23; 11,95 ± 1,79 años), 2) Sub-15 femenino (n = 9; 11,44 ± 1,23 años), 3) Absoluto mascul...

  9. Prototipo de simulador de tornado para el combate Aéreo No. 3 (CACOM 3 de la Fuerza Aérea Colombiana (FAC

    Jorge Mario Cárdenas Cabrera

    2012-09-01

    El comando CACOM 3 de la Fuerza Aérea Colombiana (FAC ha tomado la iniciativa en este aspecto y se ha dado a la tarea de estudiar este fenómeno, trabajando en el diseño de un simulador de tornados a escala, con base en el ya existente, desarrollado por el phD. Harald Eddens, introdujo modificaciones que permitan, además de generar el fenómeno, medir y controlar a través de dispositivos electrónicos algunas variables ambientales. Estos dispositivos permitirán iniciar estudios desde el comando y servir de apoyo para labores de educación de la población vulnerable en cuanto a entender cómo se forma un tornado.

  10. Sobre condiciones suficientes de estabilidad para sistemas mecánicos sometidos a fuerzas dependientes de la velocidad por el método directo de Liapunov

    Rodríguez Rebollo, Rafael

    1979-05-01

    Full Text Available Consideramos la estabilidad de un estado de un sistema mecánico, discreto o continuo, sometido a fuerzas generalizadas dependientes o no de la velocidad y cuyas ecuaciones variacionales de movimiento, para pequeñas perturbaciones, son ecuaciones diferenciales de segundo orden respecto del tiempo y de una estructura formal frecuente en diversos problemas de estabilidad de medios continuos y de sistemas de partículas y de sólidos rígidos. Se obtienen criterios de estabilidad y de estabilidad asintótica según Liapunov por el método directo, generalizando resultados conocidos. Son condiciones de estabilidad condicional para soluciones de tipo exponencial respecto del tiempo.

  11. Intervencionismo militar y cambio de régimen político: la relación entre conservadurismo y fuerzas armadas en la Argentina

    María Elina Zacarías

    2017-01-01

    Full Text Available Este artículo se propone estudiar el fenómeno del intervencionismo militar en la Argentina desde un enfoque que privilegia el análisis de las relaciones entre las fuerzas armadas y los partidos políticos conservadores. Con el foco puesto en la última experiencia de dictadura militar que tuvo lugar en el país (1976-1983, se desarrolla la tesis que postula una estrecha relación entre el grado de institucionalización de los partidos conservadores durante el periodo de la política de masas y la estabilidad del régimen democrático a lo largo del siglo XX.

  12. La pervivencia del Movimiento en la Transición: Fuerza Nueva en Almería y Jaén (1976-1982

    Aurora M. Lorite Checa

    2009-12-01

    Full Text Available En el presente trabajo se propone una aproximación, nunca cerrada, a los mecanismos de acceso al poder de Fuerza Nueva en el período de transición a la democracia, al tiempo que un análisis de la mentalidad fuerzanuevista que por entonces caló en ciertos sectores de la sociedad de Almería y Jaén; ambos elementos, que aún tienen su proyección palpable en nuestros días, condicionaron la formación y la consolidación de un partido político ultra-conservador que actualmente se está reorganizando. Para ello se analizan la formación, las estructuras organizativas y la implantación territorial, las bases y apoyos sociales, el discurso político, la organización, espacios y actividad de los sectores juveniles, la proyección actual, y finalmente, los rasgos identitarios que dan lugar a la institucionalización de una cultura política propia._____________________ABSTRACT:This work analyzes the mechanisms of access to the power of Fuerza Nueva in the period of the transition to democracy, at the time that an analysis of this mentality lost a dialectic importance in certain sectors of the society of Almeria and Jaén; both elements, that still have their concrete projection in our days, conditioned the formation and the consolidation of an ultraconservative political party that at the moment are reorganizing themselves. For it, it has been analyzed the formation, organizational structures and the territorial implantation, social bases and supports, the political speech, the organization, spaces and activity of the youthful sectors, the present projection, and finally, the self-identification characteristics that give rise to the institutionalization of a peculiar political culture.

  13. Evaluación de la calidad superficial de piezas mecanizadas a partir del análisis de la fuerza de corte

    Sánchez-Carrillero, M.

    1998-05-01

    Full Text Available Surface quality is one of the most important criteria for establishing the optima cutting parameters needed to perform a machining process. Usually, the evaluation of the degree of the surface finishing requires to apply metrological techniques which involve times out in the production. As a consequence of this, a loss in both the economy of the process and the fiability of the tests reproducibility can be produced. In this work a relation between cutting force and surface roughness has been studied for the turning process of an Al-Cu alloy. From this relation, the surface quality of the machined samples can be evaluated by using the cutting forces values acquired during the cutting process.

    El grado de acabado superficial de una pieza mecanizada es uno de los factores determinantes a la hora de establecer los parámetros de corte necesarios para llevar a cabo el proceso de mecanizado. Generalmente, la evaluación de ese grado de acabado requiere la aplicación de técnicas metrológicas que conllevan paradas de máquina y, a menudo, extracciones de piezas. Este hecho provoca la aparición de una serie de efectos negativos, no sólo en lo que a pérdidas económicas se refiere, sino a fiabilidad en la reproducción de los ensayos. En el presente trabajo se ha estudiado la relación existente entre la fuerza de corte y la rugosidad superficial para una aleación Al-Cu. A partir de esta relación se puede evaluar la calidad superficial de las muestras mecanizadas mediante la determinación de las fuerzas de corte durante el proceso.

  14. Evaluación de la fuerza de arrastre y optimización geométrica del cuerpo de un PIG con baipás

    Ricardo Ramírez

    2011-05-01

    Full Text Available Un PIG es un dispositivo o vehículo que se desplaza entre ductos, siendo utilizado en operaciones de limpieza, medición e inspección, principalmente aplicado en oleoductos y gasoductos. Baipás es el nombre de uno o varios orificios que permiten el paso de fluido de atrás hacia adelante del PIG. Es utilizado para controlar la velocidad o para mejorar el resultado de las operaciones de limpieza. En gasoductos el baipás  controla las variaciones bruscas de velocidad, evitando daños en el PIG o el ducto. Estudios y algoritmos han sido desarrollados para simular la dinámica de los PIG y su paso por los ductos. La mayoría de estos estudios son sobre ductos con gas y han servido para el diseño de algunos modelos de PIG. Este trabajo describe parte del diseño de un PIG que trabaja con líquidos, capaz de realizar tareas de inspección o mantenimiento dentro del ducto. El estudio de la fuerza que ejerce el fluido en el PIG cuando tiene baja o nula velocidad es necesario para evaluar la viabilidad del proyecto y la concepción del diseño. Al mismo tiempo, definir una forma geométrica del PIG que minimice la fuerza de interacción con el fluido permite diseñar un PIG más liviano y que cause menores pérdidas de energía.

  15. HLA-B27M1M2 and high immune responsiveness to Shigella flexneri in post-dysenteric arthritis

    van Bohemen, C. G.; Nabbe, A. J.; Landheer, J. E.; Grumet, F. C.; Mazurkiewicz, E. S.; Dinant, H. J.; Lionarons, R. J.; van Bodegom, P. C.; Zanen, H. C.

    1986-01-01

    The heterogeneous HLA-B27 antigen is closely associated with post-infectious or reactive arthritis (ReA) and is comprised of two serologically defined variants: B27M1+M2+ and B27M1+M2-. An outbreak of dysentery (n = 120) caused by a Shigella flexneri 2a strain, which possessed cell envelope antigens

  16. Development of 1 m HTS conductor using YBCO on textured metal substrate

    Yagi, M.; Sakamoto, H.; Mukoyama, S.; Yamamoto, K.; Amemiya, N.; Nagaya, S.; Kashima, N.; Shiohara, Y.

    2009-01-01

    We fabricated 1 m high temperature superconducting conductor (HTS conductor) using YBa 2 Cu 3 O 7-x coated conductors (YBCO tapes) on textured metal substrates, which are expected to be lower in cost than YBCO tapes using ion-beam assisted deposition. Those substrate and intermediate layers were manufactured by Furukawa Electric, and YBCO and a protective layer were applied to the intermediate layer by Chubu Electric Power. Before fabricating the conductor, a 0.1 mm thick copper tape was soldered to the YBCO tape, and 10 mm wide YBCO tape was divided into three strips by a YAG laser. To have sufficient current capacity for 1 kA, a two-layer conductor was fabricated, and its critical current (I c ) was 1976 A, but the magnetic properties of the textured metal substrates affected the increase in AC loss. In a low current region, the AC loss in this conductor was much higher than the Norris strip model, but approached the Norris strip model in the high current region because the magnetization was almost saturated. Low AC loss of 0.144 W/m at 1 kA rms was achieved even though the conductor had a small outer diameter of 20 mm and was composed of YBCO tapes with magnetic substrates.

  17. Calorimetric measurement of heat load in full non-inductive LHCD plasmas on TRIAM-1M

    Hanada, K.; Shinoda, N.; Sugata, T.; Sasaki, K.; Zushi, H.; Nakamura, K.; Sato, K.N.; Sakamoto, M.; Idei, H.; Hasegawa, M.; Kawasaki, S.; Nakashima, H.; Higashijima, A.

    2007-01-01

    Calorimetric measurements using the temperature increment of cooling-water were carried out to estimate the heat load distribution on the plasma facing components (PFCs) in the limiter discharges on TRIAM-1M. Line averaged electron density, n e , and LH power, P LH , dependences of the heat load on PFCs were measured. The heat load on the limiters was proportional to n e 1.5 in the range of n e =0.2-1.0x10 19 m -3 and P LH 1 in the range of P LH =0.005-0.09MW. For P LH >0.1MW, the plasma transition to an enhanced current drive (ECD) mode appeared and the n e dependences on the heat load on the limiter moderated. This indicates that the heat flux to scrape-off layer (SOL) region was reduced due to the improvement of the plasma confinement. The up-down asymmetry of the heat load on the vacuum vessel was enhanced in the ECD mode, which may be caused by the increasing of the direct loss of energetic electrons

  18. Hyperglycemia induces mixed M1/M2 cytokine profile in primary human monocyte-derived macrophages.

    Moganti, Kondaiah; Li, Feng; Schmuttermaier, Christina; Riemann, Sarah; Klüter, Harald; Gratchev, Alexei; Harmsen, Martin C; Kzhyshkowska, Julia

    2017-10-01

    Hyperglycaemia is a key factor in diabetic pathology. Macrophages are essential regulators of inflammation which can be classified into two major vectors of polarisation: classically activated macrophages (M1) and alternatively activated macrophages (M2). Both types of macrophages play a role in diabetes, where M1 and M2-produced cytokines can have detrimental effects in development of diabetes-associated inflammation and diabetic vascular complications. However, the effect of hyperglycaemia on differentiation and programming of primary human macrophages was not systematically studied. We established a unique model to assess the influence of hyperglycaemia on M1 and M2 differentiation based on primary human monocyte-derived macrophages. The effects of hyperglycaemia on the gene expression and secretion of prototype M1 cytokines TNF-alpha and IL-1beta, and prototype M2 cytokines IL-1Ra and CCL18 were quantified by RT-PCR and ELISA. Hyperglycaemia stimulated production of TNF-alpha, IL-1beta and IL-1Ra during macrophage differentiation. The effect of hyperglycaemia on TNF-alpha was acute, while the stimulating effect on IL-1beta and IL-1Ra was constitutive. Expression of CCL18 was supressed in M2 macrophages by hyperglycaemia. However the secreted levels remained to be biologically significant. Our data indicate that hyperglycaemia itself, without additional metabolic factors induces mixed M1/M2 cytokine profile that can support of diabetes-associated inflammation and development of vascular complications. Copyright © 2016 Elsevier GmbH. All rights reserved.

  19. The 1 × 1 m hypersonic wind tunnel Kochel/Tullahoma 1940-1960

    Eckardt, Dietrich

    2015-03-01

    Peenemünde and Cape Canaveral mark cornerstones of space history. Kochel in Southern Germany and Tullahoma in Tennessee, USA also belong in this category. The technically unique Kochel wind tunnel was part of the German long-distance missile development strategy, planned and prepared in secret before the beginning of World War II. A 57 MW closed-circuit wind tunnel facility with 1 × 1 m measuring section was planned for continuous-flow simulation at high Mach numbers Ma 7-10. In the early 1940 s a site beside the Walchensee Power Station at Kochel am See in Upper Bavaria, Germany was chosen to provide the required altitude difference of 200 m for the hydraulic turbine drives. The preparatory activities for the erection of this impressive hypersonic wind tunnel facility were pushed ahead until an enforced temporary pause in September 1944. In early May 1945 US troops occupied the area and, in due course, scientists of General Arnold's Scientific Advisory Group, the `von Kármán team', ordered the transfer to the USA of available equipment, design materials and other paperwork. Here, at the Arnold Engineering Development Center (AEDC) Tullahoma, TN this `Tunnel A' was built to begin operation around 1957. The testing was conducted on the Mach 7 experimental aircraft X-15, space shuttle developments and still secret investigations on unmanned hypersonic vehicles.

  20. Recent Advances in the Medicinal Chemistry of the Metabotropic Glutamate Receptor 1 (mGlu1)

    2011-01-01

    This Review summarizes the medicinal chemistry found in publications on both orthosteric and allosteric modulators of the metabotropic glutamate receptor 1 (mGlu1) from 2005 to the present. The time period covered by the scope of this current review has been particularly rich in mGlu1-related publications with numbers quadrupling when compared to the preceding five year period of 2000−2005. Publications in the field peaked in 2007 with over 35 articles appearing in the peer reviewed literature in the course of that year. Given that glutamate is one of the primary excitatory neurotransmitters in the mammalian central nervous system (CNS), it is unsurprising that it acts upon several receptors that are considered to be of potential therapeutic interest for many indications. Orthosteric and allosteric modulation of the receptor is possible, with a logical extrapolation to the chemotypes used for each strategy. The last five years of publications have yielded many mGlu1 selective antagonist chemotypyes, most of which have shown efficacy in pain in vivo models. However, the primary impact of these compounds has been to highlight the mechanistic safety risks of mGlu1 antagonism, independent of chemotype. As a review in medicinal chemistry, the primary focus of this paper will be on the design and, to a lesser degree, synthetic strategies for the delivery of subtype selective, CNS penetrant, druglike compounds through a “medchem” program, targeting modulators of the mGlu1 receptor. PMID:22860168

  1. Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia.

    Wonodi, Ikwunga; Hong, L Elliot; Stine, O Colin; Mitchell, Braxton D; Elliott, Amie; Roberts, Rosalinda C; Conley, Robert R; McMahon, Robert P; Thaker, Gunvant K

    2009-03-05

    Smooth pursuit eye movement (SPEM) deficit is an established schizophrenia endophenotype with a similar neurocognitive construct to working memory. Frontal eye field (FEF) neurons controlling SPEM maintain firing when visual sensory information is removed, and their firing rates directly correlate with SPEM velocity. We previously demonstrated a paradoxical association between a functional polymorphism of dopamine signaling (COMT gene) and SPEM. Recent evidence implicates the dopamine transporter gene (DAT1) in modulating cortical dopamine and associated neurocognitive functions. We hypothesized that DAT1 10/10 genotype, which reduces dopamine transporter expression and increases extracellular dopamine, would affect SPEM. We examined the effects of DAT1 genotype on: Clinical diagnosis in the study sample (n = 418; 190 with schizophrenia), SPEM measures in a subgroup with completed oculomotor measures (n = 200; 87 schizophrenia), and DAT1 gene expression in FEF tissue obtained from postmortem brain samples (n = 32; 16 schizophrenia). DAT1 genotype was not associated with schizophrenia. DAT1 10/10 genotype was associated with better SPEM in healthy controls, intermediate SPEM in unaffected first-degree relatives of schizophrenia subjects, and worse SPEM in schizophrenia subjects. In the gene expression study, DAT1 10/10 genotype was associated with significantly reduced DAT1 mRNA transcript in FEF tissue from healthy control donors (P < 0.05), but higher expression in schizophrenia donors. Findings suggest regulatory effects of another gene(s) or etiological factor in schizophrenia, which modulate DAT1 gene function. 2008 Wiley-Liss, Inc.

  2. High performance experiments on high pressure supersonic molecular beam injection in the HL-1M tokamak

    Yao Lianghua; Dong Jiafu; Zhou Yan; Feng Beibing; Cao Jianyong; Li Wei; Feng Zhen; Zhang Jiquan; Hong Wenyu; Cui Zhengying; Wang Enyao; Liu Yong

    2004-01-01

    Supersonic molecular beam injection (SMBI) was first proposed and demonstrated on the HL-1 tokamak and was successfully developed and used on HL-1M. Recently, new results of SMBI experiments were obtained by increasing the gas pressure from 0.5 to over 1.0 MPa. A stair-shaped density increment was obtained with high-pressure multi-pulse SMBI that was similar to the density evolution behaviour during multi-pellet injection. This demonstrated the effectiveness of SMBI as a promising fuelling tool for steady-state operation. The penetration depth and injection speed of the high-pressure SMBI were roughly measured from the contour plot of the Hα emission intensity. It was shown that injected particles could penetrate into the core region of the plasma. The penetration speed of high-pressure SMBI particles in the plasma was estimated to be about 1200 m s -1 . In addition, clusters within the beam may play an important role in the deeper injection. (author)

  3. Enhanced hydrogen entry into iron from 0.1 M NaOH at definite potentials

    Flis-Kabulska, I.; Flis, J.; Zakroczymski, T.

    2008-01-01

    This work aimed at explaining the enhancement of hydrogen entry into iron from alkaline solution occurring at definite potentials. Hydrogen permeation rate (HPR) through a 35-μm thick iron membrane was measured with the electrochemical technique in 0.1 M NaOH at 25 deg. C during cathodic and anodic polarizations. Enhanced HPR was observed at potentials of oxide reduction or iron oxidation, and potentials more cathodic than about -1.65 V NHE during prolonged galvanostatic polarization. XPS analysis showed that after the polarization, surface layers contained hydrated iron oxides and that amount of these products increased with the polarization time. It is suggested that the enhanced hydrogen entry can be explained by acidification of the near-metal solution due to iron oxidation and/or oxide reduction, and probably by a promoting effect of some Fe-O species. It is proposed that these effects are associated with surface layers. They can affect hydrogen entry as a source of protons in the oxide reduction, as a diffusion barrier making the near-metal acidification possible, and as a resistance causing an IR drop. Strong enhancement of HPR after prolonged galvanostatic polarizations can be associated with the formation of thick surface layers with IR drop enabling anodic oxidation of iron under these layers

  4. Active remote observing system for the 1-m telescope at Tonantzintla Observatory

    Bernal, Abel; Martínez, Luis A.; Hernández, Héctor; Garfias, Fernando; Ángeles, Fernando

    2006-06-01

    We have designed and installed a new active remote observing system for the 1-m, f/15 telescope at the Tonantzintla Observatory. This remote system is operated in real-time through the Internet, allowing an observer to control the building, the telescope (pointing, guiding and focusing) and the CCD image acquisition at the main and finder telescopes from the Instituto de Astronomia headquarters in Mexico City (150 KM away). The whole system was modeled within the Unified Modeling Language (UML) and the design has proved to be versatile enough for a variety of astronomical instruments. We describe the system architecture and how different subsystems (telescope control, main telescope and finder image acquisition, weather station, videoconference, etc.) that are based on different operative system platforms (Linux, Windows, uIP) have been integrated. We present the first results of an IPv6 over IPv4 tunnel. Recent remote direct imaging and spectroscopic observations have been used to test the astronomical site. We conclude that this remote system is an excellent tool for supporting research and graduated observational astronomy programs.

  5. Improved plasma confinement characteristics and central magnetohydrodynamic activity in pellet fuelled HL-1M experiment

    Liu Yi; Guo Gancheng; Zhong Yunze; Xiao Zhenggui

    1998-11-01

    In HL-1M experiment, multiple pellets were injected into Ohmic discharge, good results for plasma confinement have been achieved. The energy confinement is enhanced by up to 30% over that of usual gas fuelled discharges after a series of pellet injections. The improvement is characterized by a pressure profile that peaks strongly around the central region. It was found that the peakedness depends strongly on penetration length of the pellets, and the characteristics of MHD activity changes with peakedness of pressure profile produced by pellet injection. On the other hand, the central MHD activity plays a key role in limiting the available peaking degree. The improved discharges characterized by a highly peaked pressure profile inside q =1 surface degrade suddenly by a large sawtooth collapse. For deep penetration case, the pressure gradient in the central area becomes steep, the central magnetohydrodynamics activities are strongly affected by pellet injection. The large sawtooth crash tends to have more ideal-like characteristics in magnetic structure, which is usually observed in discharges of higher density and pressure values. The most conspicuous feature is that just at the early stage of the crash, the m = 1 continuous oscillation merges into a very localized pressure perturbation

  6. Magnetic field mapping equipment for KEK 1 m hydrogen bubble chamber magnet

    Otake, Yuji

    1979-01-01

    Magnetic field mapping was carried out for the 1 m hydrogen bubble chamber magnet in November, 1976, and March, 1977 at the National Laboratory for High Energy Physics (KEK). The magnetic field mapping equipment was manufactured for the main purposes of getting low cost and short time in manufacture, sufficient accuracy of measurement, fairly fast speed of measurement and automatic measurement. The design was made, aiming at 18 kgauss of field intensity and 10 -3 of measuring accuracy. The magnetic field mapping system consists of seven parts as shown in the block diagram. The measuring elements are Hall elements, and three elements are mounted on three surfaces of the inner wall so that three directional (X, Y and Z) components can be determined by moving the magnetic field mapping equipment. The control circuit of the equipment regulates the shift of the equipment by 5 cm step in X and Y directions. Other circuits, relays and switches are explained. Since 100 V AC power relays were placed together with TTL's and IC's in this system, relay circuits became serious noise sources. The countermeasures such as separation of IC power supply, independent grounding, are suppression and so on were taken. Of these, it was effective that relay circuit and IC circuit were put in respective shield cases, and wirings in both circuits were made so as not to intersect each other as far as possible. Finally the points to be noticed in manufacturing, obtained from the experiences, are summarized. (Wakatsuki, Y.)

  7. Newly Characterized Murine Undifferentiated Sarcoma Models Sensitive to Virotherapy with Oncolytic HSV-1 M002

    Eric K. Ring

    2017-12-01

    Full Text Available Despite advances in conventional chemotherapy, surgical techniques, and radiation, outcomes for patients with relapsed, refractory, or metastatic soft tissue sarcomas are dismal. Survivors often suffer from lasting morbidity from current treatments. New targeted therapies with less toxicity, such as those that harness the immune system, and immunocompetent murine sarcoma models to test these therapies are greatly needed. We characterized two new serendipitous murine models of undifferentiated sarcoma (SARC-28 and SARC-45 and tested their sensitivity to virotherapy with oncolytic herpes simplex virus 1 (HSV-1. Both models expressed high levels of the primary HSV entry molecule nectin-1 (CD111 and were susceptible to killing by interleukin-12 (IL-12 producing HSV-1 M002 in vitro and in vivo. M002 resulted in a significant intratumoral increase in effector CD4+ and CD8+ T cells and activated monocytes, and a decrease in myeloid-derived suppressor cells (MDSCs in immunocompetent mice. Compared to parent virus R3659 (no IL-12 production, M002 resulted in higher CD8:MDSC and CD8:T regulatory cell (Treg ratios, suggesting that M002 creates a more favorable immune tumor microenvironment. These data provide support for clinical trials targeting sarcomas with oncolytic HSV-1. These models provide an exciting opportunity to explore combination therapies for soft tissue sarcomas that rely on an intact immune system to reach full therapeutic potential.

  8. Real-time neutron radiography at the Iea-R1 m nuclear research reactor

    Menezes, M.O. de; Pugliesi, R.; Pereira, M.A.S.; Andrade, M.L.G.

    2003-01-01

    A LIXI (Light Intensifier X-ray Image) device has been employed in a real-time neutron radiography system. The LIXI is coupled to a video camera and the real-time images can be observed in a TV monitor, and processed in a computer. In order to get the real-time system operational, the neutron radiography facility installed at the IEA-R1 m nuclear research reactor of the IPEN-CNEN/S P has been optimized. The most important improvements were the neutron/gamma ratio, the effective energy of the neutron beam, decrease of the scattered radiation at the irradiation position, and the additional shielding of the video camera. Several one-frame as well as computer processed images are presented. The overall Modulation Transfer Function for the real-time system was obtained from the resolution parameter p = 0:44 +- 0:04 mm; the system sensitivity, evaluated for a Perspex step wedge, was determined and the average value is 0:70 +- 0:09 mm. (author)

  9. Current ramp-up experiments in full current drive plasmas in TRIAM-1M

    Hanada, K.; Nakamura, K.; Hasegawa, M.; Itoh, S.; Zushi, H.; Sakamoto, M.; Jotaki, E.; Iyomasa, A.; Kawasaki, S.; Nakashima, H.; Yoshida, N.; Tokunaga, K.; Fujiwara, T.; Kulkarni, S.V.; Mitarai, O.

    2004-01-01

    Four types of plasma current ramp-up experiments in full non-inductively lower hybrid current driven (LHCD) plasmas were executed in TRIAM-1M: (1) current start-up by a combination of electron cyclotron resonance heating (ECRH) and LHCD, (2) tail heating by additional LHCD, (3) bulk heating by ECRH and (4) spontaneous ramp-up by a transition to enhanced current drive (ECD) mode. The time evolutions of plasma current during four types of ramp-up phase were adjusted by a simple model with two different time constants, which are a time defined by the total current diffusion time and a time constant for improving the current drive efficiency. In the case of (1) and (4), the latter time constant is significant during the current ramp-up phase. The improvement in the current drive efficiency in the ECD mode is likely to be caused by the increase in the effective refractive index along the magnetic field of the lower hybrid wave. (author)

  10. 1/M corrections to baryonic form factors in the quark model

    Cheng, H.; Tseng, B.

    1996-01-01

    Weak current-induced baryonic form factors at zero recoil are evaluated in the rest frame of the heavy parent baryon using the nonrelativistic quark model. Contrary to previous similar work in the literature, our quark model results do satisfy the constraints imposed by heavy quark symmetry for heavy-heavy baryon transitions at the symmetric point v·v'=1 and are in agreement with the predictions of the heavy quark effective theory for antitriplet-antitriplet heavy baryon form factors at zero recoil evaluated to order 1/m Q . Furthermore, the quark model approach has the merit that it is applicable to any heavy-heavy and heavy-light baryonic transitions at maximum q 2 . Assuming a dipole q 2 behavior, we have applied the quark model form factors to nonleptonic, semileptonic, and weak radiative decays of the heavy baryons. It is emphasized that the flavor suppression factor occurring in many heavy-light baryonic transitions, which is unfortunately overlooked in most literature, is very crucial towards an agreement between theory and experiment for the semileptonic decay Λ c →Λe + ν e . Predictions for the decay modes Λ b →J/ψΛ, Λ c →pφ, Λ b →Λγ, Ξ b →Ξγ, and for the semileptonic decays of Λ b , Ξ b, c, and Ω b are presented. copyright 1996 The American Physical Society

  11. GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia.

    Hsien-Sung Huang

    2007-08-01

    Full Text Available Dysfunction of prefrontal cortex in schizophrenia includes changes in GABAergic mRNAs, including decreased expression of GAD1, encoding the 67 kDa glutamate decarboxylase (GAD67 GABA synthesis enzyme. The underlying molecular mechanisms remain unclear. Alterations in DNA methylation as an epigenetic regulator of gene expression are thought to play a role but this hypothesis is difficult to test because no techniques are available to extract DNA from GAD1 expressing neurons efficiently from human postmortem brain. Here, we present an alternative approach that is based on immunoprecipitation of mononucleosomes with anti-methyl-histone antibodies differentiating between sites of potential gene expression as opposed to repressive or silenced chromatin. Methylation patterns of CpG dinucleotides at the GAD1 proximal promoter and intron 2 were determined for each of the two chromatin fractions separately, using a case-control design for 14 schizophrenia subjects affected by a decrease in prefrontal GAD1 mRNA levels. In controls, the methylation frequencies at CpG dinucleotides, while overall higher in repressive as compared to open chromatin, did not exceed 5% at the proximal GAD1 promoter and 30% within intron 2. Subjects with schizophrenia showed a significant, on average 8-fold deficit in repressive chromatin-associated DNA methylation at the promoter. These results suggest that chromatin remodeling mechanisms are involved in dysregulated GABAergic gene expression in schizophrenia.

  12. Antifungal drugs as corrosion inhibitors for aluminium in 0.1 M HCl

    Obot, I.B. [Department of Chemistry, Faculty of Science, University of Uyo, Uyo (Nigeria)], E-mail: proffoime@yahoo.com; Obi-Egbedi, N.O. [Department of Chemistry, University of Ibadan, Ibadan (Nigeria); Umoren, S.A. [Department of Chemistry, Faculty of Science, University of Uyo, Uyo (Nigeria)

    2009-08-15

    The inhibitive capabilities of Clotrimazole (CTM) and Fluconazole (FLC), two antifungal drugs, on the electrochemical corrosion of aluminium in 0.1 M HCl solution has been studied using weight loss measurements at 30 and 50 deg. C. The results indicate that both compound act as inhibitors in the acidic corrodent. At constant acid concentration, the inhibition efficiency (%I) increased with increase in the concentration of the inhibitors. Increase in temperature increased the corrosion rate in the absence and presence of the inhibitors but decreased the inhibition efficiency. CTM and FLC adsorbed on the surface of aluminium according to the Langmuir adsorption isotherm model at all the concentrations and temperatures studied. Phenomenon of physical adsorption is proposed from the activation parameter obtained. Thermodynamic parameters reveal that the adsorption process is spontaneous. The reactivity of these compounds was analyzed through theoretical calculations based on AM1 semi-empirical method to explain the different efficiencies of these compounds as corrosion inhibitors. CTM was found to be a better inhibitor than FLC.

  13. Production of the 4.1-m Zerodur mirror blank for the VISTA Telescope

    Doehring, Thorsten; Jedamzik, Ralf; Wittmer, Volker; Thomas, Armin

    2004-09-01

    VISTA (Visible and Infrared Survey Telescope for Astronomy) is designed to be the world's largest wide field telescope. After finishing of the construction the telescope will be part of ESO and located in Chile close to the VLT observatory at Cerro Paranal. In November 2001 SCHOTT was selected by the VISTA project office at the Royal Observatory of Edinburgh to deliver the 4.1 m diameter primary mirror blank. The manufacturing of the mirror blank made from the zero expansion material Zerodur was challenging especially due to the f/1 design. Several tons of the glass ceramic material were removed during the grinding operation. A meniscus blank with a diameter of 4100 mm and a thickness of 171.5 mm was generated, having a large central hole of 1200 mm and an aspherical shape of the concave surface. Also the handling and turning operations needed special effort and were performed by a skilled team. This paper presents details and pictures of the corresponding production and inspection sequence at SCHOTT. The geometrical parameters were measured during manufacturing by help of a laser tracker system and the achieved parameters were compared with the initial technical specification. The final quality inspection verified the excellent quality of the mirror blank. The close co-operation between the astronomers and industry resulted in a project management without problems. In April 2003 the VISTA blank was delivered successfully within a ceremony dedicated to the anniversary of "100 years of astronomical mirror blanks from SCHOTT."

  14. Recent progresses on high performance steady-state plasmas in the superconducting tokamak TRIAM-1M

    Itoh, Satoshi; Sato, Kohnosuke; Nakamura, Kazuo

    1999-01-01

    The overview of TRIAM-1M experiments is described. The up-to-date issues for steady-state operation are presented through the experience of the achievement of super ultra long tokamak discharges (SULD) sustained by lower hybrid current drive (LHCD) over 2 hours. The importance of the control of an initial phase of plasma, the avoidance of the concentration of huge heat load, the wall conditioning, and abrupt stop of the long discharges are proposed as the indispensable issues for the achievement of the steady-state operation of tokamak. A high ion temperature (HIT) discharge fully sustained by 2.45 GHz LHCD with both high ion temperature and steep temperature gradient is successfully demonstrated for longer than 1 min in the limiter configuration. The HIT discharges can be obtained in the narrow window of density and position. Moreover, the avoidance of the concentration of heat load on a limiter is the key point for the achievement and its long sustainment. As the effective thermal insulation between the wall and the plasma is improved on the single null configuration, HIT discharges with peak ion temperature > 5keV and steeper gradient up to 85 keV/m can be achieved by the exquisite control of density and position. The plasmas with high κ ∼1.5 can be also demonstrated for longer than 1 min. The current profile is also well-controlled for about 2 orders in magnitude longer than the current diffusion time using combined LHCD. The serious damage to the material of the first wall caused by energetic neutral particles produced via charge exchange process is also described. As the neutral particles cannot be affected by magnetic field, this damage by neutral particles must be avoided by the new technique. (author)

  15. Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.

    Shweta Joshi

    Full Text Available Although it is well-established that the macrophage M1 to M2 transition plays a role in tumor progression, the molecular basis for this process remains incompletely understood. Herein, we demonstrate that the small GTPase, Rac2 controls macrophage M1 to M2 differentiation and the metastatic phenotype in vivo. Using a genetic approach, combined with syngeneic and orthotopic tumor models we demonstrate that Rac2-/- mice display a marked defect in tumor growth, angiogenesis and metastasis. Microarray, RT-PCR and metabolomic analysis on bone marrow derived macrophages isolated from the Rac2-/- mice identify an important role for Rac2 in M2 macrophage differentiation. Furthermore, we define a novel molecular mechanism by which signals transmitted from the extracellular matrix via the α4β1 integrin and MCSF receptor lead to the activation of Rac2 and potentially regulate macrophage M2 differentiation. Collectively, our findings demonstrate a macrophage autonomous process by which the Rac2 GTPase is activated downstream of the α4β1 integrin and the MCSF receptor to control tumor growth, metastasis and macrophage differentiation into the M2 phenotype. Finally, using gene expression and metabolomic data from our Rac2-/- model, and information related to M1-M2 macrophage differentiation curated from the literature we executed a systems biologic analysis of hierarchical protein-protein interaction networks in an effort to develop an iterative interactome map which will predict additional mechanisms by which Rac2 may coordinately control macrophage M1 to M2 differentiation and metastasis.

  16. Relación entre la fuerza máxima en squat y acciones de salto, sprint y golpeo de balón. (Relationship among maximal strength in squat exercise, jump, sprint and kicking ball performance.

    Alfredo Arija Blázquez

    2008-01-01

    Full Text Available ResumenEl objetivo del presente estudio fue analizar las posibles relaciones entre la fuerza máxima en squat y accionesexplosivas de salto, sprint y golpeo de balón. Para ello, se contó con una muestra formada por estudiantes de Ciencias del Deporte (N= 16; 19,6 ± 1,7 años de sexo masculino (con escasa experiencia en el entrenamiento de fuerza, que llevaron a cabo un test de 1RM en squat (calculándose el peso levantado, la fuerza media total y la fuerza dinámica máxima, tests de salto vertical (SJ, CMJ y CMJa, un test de sprint de 20 m (con mediciones de tiempo cada 5 m, y un test de golpeo con el pie donde se calculaba la velocidad del balón. Se encontraron coeficientes de correlación moderados (entre 0,52 y 0,67 y significativos de las medidas de fuerza máxima y las alturas de salto, mientras que los coeficientes obtenidos entre los tiempos de sprint y dichas medidas de fuerza máxima se situaron entre -0,06 y -0,32, no siendo ninguno de ellos significativo; al igual que tampoco fueron significativos los coeficientes de correlación de las medidas de fuerza máxima y la velocidad de tiro, se situaron entre 0,25 y 0,34. Por tanto, la relación entre la fuerza máxima en squat y la altura de salto en sujetos con escasa experiencia en el entrenamiento de fuerza resultó moderada, mientras que no parece existir relación con el tiempo de sprint y la velocidad de tiro.AbstractThe purpose of the present study was to analyze the possible relationships between maximal strength insquat exercise and jump, sprint and kicking ball actions. Sixteen males sport science students (19,6 ± 1,7years, with little experience in strength training, performed a 1RM in squat exercise (from which liftedweight, the total average- and maximal-dynamic strength was assessed, vertical jump (SJ, CMJ and CMJa, a 20 m sprint test (with time measurement every 5 m, and a kicking ball test where the velocity of the ball was calculated. Moderate (0,52 - 0,67 and

  17. Efectos de diferentes intensidades relativas, volúmenes, tiempos de recuperación entre repeticiones y pérdida de velocidad en la serie sobre el rendimiento en sprint, salto vertical con cargas y sin cargas y la fuerza de las extremidades inferiores

    Mora Custodio, Ricardo

    2017-01-01

    Programa de Doctorado en Ciencias de la Actividad Física y del Deporte En la presente tesis doctoral se llevaron a cabo cuatro estudios y tuvo como objetivo analizar los efectos producidos por diferentes configuraciones del entrenamiento de fuerza sobre el rendimiento en sprint, salto vertical y la fuerza máxima. En el Estudio I se analizó el efecto producido por dos programas de entrenamiento de fuerza equivalentes en todas sus variables excepto en la intensidad relativa (Cargas bajas 40...

  18. Current ramp-up experiments in full current drive plasmas on TRIAM-1M

    Hanada, K.; Nakamura, K.; Hasegawa, M.

    2003-01-01

    Four types of plasma current ramp-up experiments were executed on TRIAM-1M in full lower hybrid current drive plasmas (LHCD: 8.2GHz, up to 0.4 MW, 8 x 2 grill antenna); 1) the current start up by the combination between electron cyclotron resonance heating (ECH: 170GHz, up to 0.2 MW, O-mode launching) and LHCD at the density of ∼2x10 19 m -3 at B t =6.7T, 2) the tail heating by the additional LHCD, 3) the bulk heating by ECH, 4) the spontaneous ramp up by the transition to enhanced current drive (ECD) mode. The time evolutions of plasma current during four types of ramp-up phase were investigated and an exponential type and a tangent-hyperbolic one were observed. The time evolutions of plasma current during the tail and the bulk heating show the exponential type except the tail heating with high n parallel and it has a tangent-hyperbolic one during the ECD mode and the current start-up. A simple model with two different time constants, which are a time defined by L/R, τ L/R , and a time caused by change of the effective refractive index along the magnetic field, τ, is proposed to explain two types of the time evolution of the plasma current. The estimated τ L/R is consistent with the calculated one from the plasma parameter. It is found that τ are less than τ L/R in the cases of the tail and the bulk heating, and comparable in the cases of the ECD mode, and more than τ L/R in the cases of the plasma start-up. This indicates that the value of the effective refractive index along the magnetic field, parallel >, develops during the ECD mode and the current start-up. The value of τ depends on the RF power. The estimated is close to the expected up-shifted n parallel due to the toroidal effect and the magnetic shear. (author)

  19. Characterization and commissioning of the SST-1M camera for the Cherenkov Telescope Array

    Aguilar, J.A. [Université Libre Bruxelles, Faculté des Sciences, Avenue Franklin Roosevelt 50, 1050 Brussels (Belgium); DPNC - Université de Genéve, 24 Quai Ernest Ansermet, Genéve (Switzerland); Department of Information Technologies, Jagiellonian University, ul. prof. Stanisława Łojasiewicza 11, 30–348 Kraków (Poland); Bilnik, W. [AGH University of Science and Technology, al.Mickiewicza 30, Kraków (Poland); Department of Information Technologies, Jagiellonian University, ul. prof. Stanisława Łojasiewicza 11, 30–348 Kraków (Poland); Błocki, J. [Instytut Fizyki Jadrowej im. H. Niewodniczańskiego Polskiej Akademii Nauk, ul. Radzikowskiego 152, 31–342 Kraków (Poland); Department of Information Technologies, Jagiellonian University, ul. prof. Stanisława Łojasiewicza 11, 30–348 Kraków (Poland); Bogacz, L. [Astronomical Observatory, Jagiellonian University, ul. Orla 171, 30–244 Kraków (Poland); Department of Information Technologies, Jagiellonian University, ul. prof. Stanisława Łojasiewicza 11, 30–348 Kraków (Poland); and others

    2017-02-11

    The Cherenkov Telescope Array (CTA), the next generation very high energy gamma-rays observatory, will consist of three types of telescopes: large (LST), medium (MST) and small (SST) size telescopes. The SSTs are dedicated to the observation of gamma-rays with energy between a few TeV and a few hundreds of TeV. The SST array is expected to have 70 telescopes of different designs. The single-mirror small size telescope (SST-1 M) is one of the proposed telescope designs under consideration for the SST array. It will be equipped with a 4 m diameter segmented mirror dish and with an innovative camera based on silicon photomultipliers (SiPMs). The challenge is not only to build a telescope with exceptional performance but to do it foreseeing its mass production. To address both of these challenges, the camera adopts innovative solutions both for the optical system and readout. The Photo-Detection Plane (PDP) of the camera is composed of 1296 pixels, each made of a hollow, hexagonal light guide coupled to a hexagonal SiPM designed by the University of Geneva and Hamamatsu. As no commercial ASIC would satisfy the CTA requirements when coupled to such a large sensor, dedicated preamplifier electronics have been designed. The readout electronics also use an innovative approach in gamma-ray astronomy by adopting a fully digital approach. All signals coming from the PDP are digitized in a 250 MHz Fast ADC and stored in ring buffers waiting for a trigger decision to send them to the pre-processing server where calibration and higher level triggers will decide whether the data are stored. The latest generation of FPGAs is used to achieve high data rates and also to exploit all the flexibility of the system. As an example each event can be flagged according to its trigger pattern. All of these features have been demonstrated in laboratory measurements on realistic elements and the results of these measurements will be presented in this contribution.

  20. Desarrollo de un Banco de Pruebas Experimental mediante Control de Fuerza con Robot Industrial para el Análisis de la Respuesta Mecánica de Asientos de Coche

    A. Valera

    2009-04-01

    Full Text Available Resumen: Este trabajo presenta el desarrollo de un banco de pruebas experimental para el análisis de la respuesta mecánica de los asientos de vehículos durante la entrada y salida de pasajeros. Para realizar este desarrollo, se consideran dos fases: la primera fase es la captura de datos, realizada mediante una manta sensorizada con una red de galgas de presión y un sistema de fotogrametría a fin de capturar el movimiento realizado por una persona al sentarse en el asiento de un automóvil. La segunda fase consiste en reproducir dicho movimiento de forma automática mediante un maniquí acoplado a un robot, controlando la fuerza que ejerce el maniquí sobre el asiento.El desarrollo debe permitir aplicar diferentes estrategias de control de fuerza con robots industriales, utilizando para ello una plataforma de prueba consistente en el robot IRB140 de ABB y un sensor de fuerza industrial JR3 de 6 grados de libertad. Como arquitectura de control, se presentan dos alternativas. La primera utiliza la aplicación software WebWare SDK de ABB. En la segunda solución, se ha modificado el controlador original S4CPlus del robot, proporcionando una arquitectura abierta de control que permite la implementación de nuevos algoritmos de control de movimiento y fuerza en el robot industrial.Con esta aplicación, se simula el proceso realizado por una persona al sentarse y levantarse del asiento de un automóvil, monitorizándose y controlándose la fuerza que ejerce un maniquí sobre un asiento para garantizar igualdad de condiciones con el caso real. El sistema desarrollado tiene numerosas aplicaciones prácticas, como por ejemplo la de poder analizar el desgaste que estos movimientos ocasionan en la tapicería de los asientos. Palabras clave: control de fuerza, control de robots, simulación de movimientos humanos, control por computador, aplicaciones digitales de computación, robots manipuladores

  1. China Dimensions Data Collection: China Administrative Regions GIS Data: 1:1M, County Level, 1 July 1990

    National Aeronautics and Space Administration — China Administrative Regions GIS Data: 1:1M, County Level, 1 July 1990 consists of geographic boundary data for the administrative regions of China as of 1 July...

  2. Determination of lutetium (III) hydrolysis constants in the middle of ion force 1M sodium chloride at 303 K

    Jimenez R, M.; Solache R, M.J.; Ramirez G, J.J.; Rojas H, A.

    1997-01-01

    With the purpose to complete information about the lutetium (III) hydrolysis constants here is used the potentiometric method to determine those in the middle of ion force 1M sodium chloride at 303 K. (Author)

  3. Relation between 1m depth temperature and average geothermal gradient at 75cm depth in geothermal fields

    江原, 幸雄

    2009-01-01

    Shallow ground temperatures such as 1m depth temperature have been measured to delineate thermal anomalies of geothermal fields and also to estimate heat discharge rates from geothermal fields. As a result, a close linear relation between 1m depth temperature and average geothermal gradient at 75cm depth has been recognized in many geothermal fields and was used to estimate conductive heat discharge rates. However, such a linear relation may show that the shallow thermal regime in geothermal ...

  4. Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability

    Zhang, Jingjie; Ouyang, Weiming; Li, Jingxia; Zhang, Dongyun; Yu, Yonghui; Wang, York; Li, Xuejun; Huang, Chuanshu

    2012-01-01

    Suberoylanilide hydroxamic acid (SAHA) inhibiting cancer cell growth has been associated with its downregulation of cyclin D1 protein expression at transcription level or translation level. Here, we have demonstrated that SAHA inhibited EGF-induced Cl41 cell transformation via the decrease of cyclin D1 mRNA stability and induction of G0/G1 growth arrest. We found that SAHA treatment resulted in the dramatic inhibition of EGF-induced cell transformation, cyclin D1 protein expression and induction of G0/G1 growth arrest. Further studies showed that SAHA downregulation of cyclin D1 was only observed with endogenous cyclin D1, but not with reconstitutionally expressed cyclin D1 in the same cells, excluding the possibility of SAHA regulating cyclin D1 at level of protein degradation. Moreover, SAHA inhibited EGF-induced cyclin d1 mRNA level, whereas it did not show any inhibitory effect on cyclin D1 promoter-driven luciferase reporter activity under the same experimental conditions, suggesting that SAHA may decrease cyclin D1 mRNA stability. This notion was supported by the results that treatment of cells with SAHA decreased the half-life of cyclin D1 mRNA from 6.95 h to 2.57 h. Consistent with downregulation of cyclin D1 mRNA stability, SAHA treatment also attenuated HuR expression, which has been well-characterized as a positive regulator of cyclin D1 mRNA stability. Thus, our study identifies a novel mechanism responsible for SAHA inhibiting cell transformation via decreasing cyclin D1 mRNA stability and induction of G0/G1 growth arrest in Cl41 cells. -- Highlights: ► SAHA inhibits cell transformation in Cl41 cells. ► SAHA suppresses Cyclin D1 protein expression. ► SAHA decreases cyclin D1 mRNA stability.

  5. Acute Endoplasmic Reticulum Stress-Independent Unconventional Splicing of XBP1 mRNA in the Nucleus of Mammalian Cells

    Yuanyuan Wang

    2015-06-01

    Full Text Available The regulation of expression of X-box-binding protein-1 (XBP1, a transcriptional factor, involves an unconventional mRNA splicing that removes the 26 nucleotides intron. In contrast to the conventional splicing that exclusively takes place in the nucleus, determining the location of unconventional splicing still remains controversial. This study was designed to examine whether the unconventional spicing of XBP1 mRNA could occur in the nucleus and its possible biological relevance. We use RT-PCR reverse transcription system and the expand high fidelity PCR system to detect spliced XBP1 mRNA, and fraction cells to determine the location of the unconventional splicing of XBP1 mRNA. We employ reporter constructs to show the presence of unconventional splicing machinery in mammal cells independently of acute endoplasmic reticulum (ER stress. Our results reveal the presence of basal unconventional splicing of XBP1 mRNA in the nucleus that also requires inositol-requiring transmembrane kinase and endonuclease 1α (IRE1α and can occur independently of acute ER stress. Furthermore, we confirm that acute ER stress induces the splicing of XBP1 mRNA predominantly occurring in the cytoplasm, but it also promotes the splicing in the nucleus. The deletion of 5′-nucleotides in XBP1 mRNA significantly increases its basal unconventional splicing, suggesting that the secondary structure of XBP1 mRNA may determine the location of unconventional splicing. These results suggest that the unconventional splicing of XBP1 mRNA can take place in the nucleus and/or cytoplasm, which possibly depends on the elaborate regulation. The acute ER stress-independent unconventional splicing in the nucleus is most likely required for the maintaining of day-to-day folding protein homeostasis.

  6. CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer

    Paula Mota

    2010-01-01

    Full Text Available Lung cancer is considered an environment-related disease that develops as a consequence of exposure to mutagenic agents, namely those present in tobacco. The CYP1A1 gene codifies the phase I enzyme aryl hydrocarbon hydroxilase (AHH belonging to the cytochrome P450 system that plays a major role in the bio-activation of tobacco procarcinogenes. Two CYP1A1 polymorphisms, m1 (T6235C transition and m2 (A4889G transition, are associated with greater enzymatic activity and have been described as genetic susceptibility factors for lung cancer.The aim of this study was to verify if this association holds true in blood samples of 175 lung cancer patients and 217 non-cancer patients from Portugal's midlands region. The samples were studied by restriction fragment length polymorphism (RFLP assay.The allelic frequencies of the mutant alleles were 0.12 for allele C and 1.14 for allele G in the control population. The results were not statistically different from those alleles in the patient population. There was also no statistically significant difference in genotype distribution in lung cancer patients and controls even when combining high risk genotypes. In our control sample, as in other populations of different ethnic origin, both polymorphisms also seem to be in linkage disequilibrium. We conclude that in this sample of the Portuguese population, CYP1A1 m1 and m2 polymorphisms are too rare to be of clinical relevance, and do not seem to be associated with susceptibility to lung cancer. Resumo: O cancro do pulmão é considerado uma doença relacionada com o meio ambiente, consequência da exposição a agentes mutagénicos, nomeadamente os presentes no fumo do tabaco. O gene CYP1A1 codifica a enzima aril hidrocarboneto hidroxilase (AHH, da fase I, do sistema multienzimático do citocromo P450, que desempenha uma função preponderante na bioactivação dos procarcinogénios do tabaco. Dois polimorfismos do CYP1A1, m1 (transi

  7. Nitric oxide signaling pathway regulates potassium chloride cotransporter-1 mRNA expression in vascular smooth muscle cells.

    Di Fulvio, M; Lauf, P K; Adragna, N C

    2001-11-30

    Rat vascular smooth muscle cells (VSMCs) express at least two mRNAs for K-Cl cotransporters (KCC): KCC1 and KCC3. cGMP-dependent protein kinase I regulates KCC3 mRNA expression in these cells. Here, we show evidence implicating the nitric oxide (NO)/cGMP signaling pathway in the expression of KCC1 mRNA, considered to be the major cell volume regulator. VSMCs, expressing soluble guanylyl cyclase (sGC) and PKG-I isoforms showed a time- and concentration-dependent increase in KCC1 mRNA levels after treatment with sodium nitroprusside as demonstrated by semiquantitative RT-PCR. sGC-dependent regulation of KCC1 mRNA expression was confirmed using YC-1, a NO-independent sGC stimulator. The sGC inhibitor LY83583 blocked the effects of sodium nitroprusside and YC-1. Moreover, 8-Br-cGMP increased KCC1 mRNA expression in a concentration- and time-dependent fashion. The 8-Br-cGMP effect was partially blocked by KT5823 but not by actinomycin D. However, actinomycin D and cycloheximide increased basal KCC1 mRNA in an additive manner, suggesting different mechanisms of action for both drugs. These findings suggest that in VSMCs, the NO/cGMP-signaling pathway participates in KCC1 mRNA regulation at the post-transcriptional level.

  8. EFECTO DEL ENTRENAMIENTO INTEGRADO SOBRE LA MEJORA DE LA FUERZA DE IMPULSIÓN EN UN LANZAMIENTO EN SUSPENSIÓN EN BALONMANO

    P. Padial

    2010-09-01

    Full Text Available

     

    RESUMEN


    Se ha analizado el efecto de dos tipos diferentes de entrenamiento en balonmano, uno que integra carga física y técnica dentro del mismo ejercicio (entrenamiento integrado, y otro que sigue los cánones tradicionales (entrenamiento de fuerza y entrenamiento técnico se trabajan por separado. Se trataba de comprobar el efecto de entrenar cargas pesadas más lanzamiento inmediato dentro de una acción táctica y contrastar esto con un método de entrenamiento más tradicional en balonmano. Muestra: 16 sujetos (16-17años, varones, pertenecientes al CDU de Granada. Procedimiento: Dos grupos de 8 sujetos cada uno, el primer grupo es el experimental que realiza el entrenamiento integrado (EI y el segundo grupo es el de control (GC que realiza el entrenamiento tradicional, ambos grupos entrenaron 2 veces a la semana, durante 7 semanas consecutivas. La intensidad del entrenamiento y la carga fue la misma para los dos grupos. Se realizaron medidas de la altura de salto en SJ, CMJ, SJ25, SJ50 y AB en la 3 y 7ª semana de entrenamiento, con plataforma de presión. Resultados: Con el entrenamiento integrado se produce un incremento muy significativo en todas manifest incremento mejor que el grupo en el con carga. nes: El entrenamiento integrado con cargas del de la manifestaciones de fuerza dinámica. Para jóvenes jugadores de balonmano se presenta como un método muy interesante de mejora de la fuerza máxima dinámica.
    PALABRAS CLAVE:

     

    ABSTRACT

    Researchers analyzed different methodologies handball training. One method combines strength and technique the same (integrated training the other traditional principles separate training and practice. during technical action contrast that a more

  9. Thermal-Hydraulic Simulations of Single Pin and Assembly Sector for IVG- 1M Reactor

    Kraus, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Garner, P. [Argonne National Lab. (ANL), Argonne, IL (United States); Hanan, N. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-01-15

    Thermal-hydraulic simulations have been performed using computational fluid dynamics (CFD) for the highly-enriched uranium (HEU) design of the IVG.1M reactor at the Institute of Atomic Energy (IAE) at the National Nuclear Center (NNC) in the Republic of Kazakhstan. Steady-state simulations were performed for both types of fuel assembly (FA), i.e. the FA in rows 1 & 2 and the FA in row 3, as well as for single pins in those FA (600 mm and 800 mm pins). Both single pin calculations and bundle sectors have been simulated for the most conservative operating conditions corresponding to the 10 MW output power, which corresponds to a pin unit cell Reynolds number of only about 7500. Simulations were performed using the commercial code STAR-CCM+ for the actual twisted pin geometry as well as a straight-pin approximation. Various Reynolds-Averaged Navier-Stokes (RANS) turbulence models gave different results, and so some validation runs with a higher-fidelity Large Eddy Simulation (LES) code were performed given the lack of experimental data. These singled out the Realizable Two-Layer k-ε as the most accurate turbulence model for estimating surface temperature. Single-pin results for the twisted case, based on the average flow rate per pin and peak pin power, were conservative for peak clad surface temperature compared to the bundle results. Also the straight-pin calculations were conservative as compared to the twisted pin simulations, as expected, but the single-pin straight case was not always conservative with regard to the straight-pin bundle. This was due to the straight-pin temperature distribution being strongly influenced by the pin orientation, particularly near the outer boundary. The straight-pin case also predicted the peak temperature to be in a different location than the twisted-pin case. This is a limitation of the straight-pin approach. The peak temperature pin was in a different location from the peak power pin in every case simulated, and occurred at an

  10. Efectos del pH, NaCl, CaCl2 y la temperatura sobre la fuerza de cuajo de tres coagulantes/cuajos

    Osmar Thomas Morillo Piña

    2014-06-01

    Full Text Available El cuajo y los coagulantes juegan un papel fundamental en el proceso de elaboración de queso y su actividad se ve afectada por diversos parámetros tecnológicos. En este sentido se determinó el efecto del pH, concentración de NaCl, CaCl2 y de la temperatura sobre la fuerza de cuajo de un coagulante microbiano experimental (BIOMI-13, una quimosina recombinante comercial (Maxiren® y un cuajo comercial de origen animal (BIOVEN, preparados a concentraciones de 0,05 g/mL; 0,0004 g/mL y 0,0008 g/mL, respectivamente. El efecto del pH fue evaluado en un intervalo de 5,0 a 7,5 y la concentración de NaCl y CaCl2 en la leche entre 0,02 y 0,16 M. El efecto de los iones de Na y Ca en las soluciones enzimáticas fue evaluado entre 0,04 y 0,80 M y la temperatura de incubación entre 20 y 70 ºC. Se determinó que los cambios de pH tienen un efecto inversamente proporcional sobre la actividad coagulante de la leche y la máxima actividad fue a pH 5 para los tres coagulantes evaluados. La concentración de NaCl en la leche tuvo un efecto adverso sobre la actividad coagulante, mientras que el incremento de la [CaCl2] aumentó la actividad alcanzando valores máximos a 0,04 M. La presencia iones de Na en las soluciones enzimáticas tuvo el mismo efecto observado en las pruebas de concentración de NaCl en la leche y se observó un aumento de la actividad relativa conforme se incrementó la concentración de iones de Ca en la solución. Los tres coagulantes/cuajos evaluados exhibieron la máxima fuerza de cuajo a 45 ºC y tuvieron una acción catalítica muy específica sobre la leche con una marcada dependencia a los parámetros evaluados, presentando algunas diferencias entre ellos debido posiblemente a la fuente y forma de obtención.

  11. Efectos del pH, NaCl, CaCl2 y la temperatura sobre la fuerza de cuajo de tres coagulantes/cuajos

    Osmar Thomas Morillo Piña

    2014-07-01

    Full Text Available El cuajo y los coagulantes juegan un papel fundamental en el proceso de elaboración de queso y su actividad se ve afectada por diversos parámetros tecnológicos. En este sentido se determinó el efecto del pH, concentración de NaCl, CaCl2 y de la temperatura sobre la fuerza de cuajo de un coagulante microbiano experimental (BIOMI-13, una quimosina recombinante comercial (Maxiren® y un cuajo comercial de origen animal (BIOVEN, preparados a concentraciones de 0,05 g/mL; 0,0004 g/mL y 0,0008 g/mL, respectivamente. El efecto del pH fue evaluado en un intervalo de 5,0 a 7,5 y la concentración de NaCl y CaCl2 en la leche entre 0,02 y 0,16 M. El efecto de los iones de Na y Ca en las soluciones enzimáticas fue evaluado entre 0,04 y 0,80 M y la temperatura de incubación entre 20 y 70 ºC. Se determinó que los cambios de pH tienen un efecto inversamente proporcional sobre la actividad coagulante de la leche y la máxima actividad fue a pH 5 para los tres coagulantes evaluados. La concentración de NaCl en la leche tuvo un efecto adverso sobre la actividad coagulante, mientras que el incremento de la [CaCl2] aumentó la actividad alcanzando valores máximos a 0,04 M. La presencia iones de Na en las soluciones enzimáticas tuvo el mismo efecto observado en las pruebas de concentración de NaCl en la leche y se observó un aumento de la actividad relativa conforme se incrementó la concentración de iones de Ca en la solución. Los tres coagulantes/cuajos evaluados exhibieron la máxima fuerza de cuajo a 45 ºC y tuvieron una acción catalítica muy específica sobre la leche con una marcada dependencia a los parámetros evaluados, presentando algunas diferencias entre ellos debido posiblemente a la fuente y forma de obtención.

  12. Estudio del efecto de la fuerza iónica en la adsorción de fenol con arcillas organofílicas: Equilibrio y cinética

    Sun-Kou, María del Rosario; Lazo, José Carlos

    2009-01-01

    Se estudió el efecto de la fuerza iónica en el proceso de adsorción de fenol con arcillas organofilicas así como la cinética de reacción. Para el estudio de la fuerza iónica se evaluó la capacidad de adsorción de fenol de tres arcillas organofilicas, -preparadas por intercambio catiónico con sales de amonio cuaternario- en presencia de NaCI en soluciones cuya concentración de fenol varió en el rango de 50-800 ppm y la proporción de sal fue 2, 12 y 20% (w/v), respectivamente. Todas las arcilla...

  13. Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function.

    Regina T Knapp

    Full Text Available Hsp70 binding protein 1 (HspBP1 and Bcl2-associated athanogene 1 (BAG-1, the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70 chaperones, catalyze the release of ADP from Hsp70 while inducing different conformational changes of the ATPase domain of Hsp70. An appropriate exchange rate of ADP/ATP is crucial for chaperone-dependent protein folding processes. Among Hsp70 client proteins are steroid receptors such as the glucocorticoid receptor (GR, the mineralocorticoid receptor (MR, and the androgen receptor (AR. BAG-1 diversely affects steroid receptor activity, while to date the influence of HspBP1 on steroid receptor function is mostly unknown. Here, we compared the influence of HspBP1 and BAG-1M on Hsp70-mediated steroid receptor folding complexes and steroid receptor activity. Coimmunoprecipitation studies indicated preferential binding of Hsp40 and the steroid receptors to BAG-1M as compared to HspBP1. Furthermore, Hsp70 binding to the ligand-binding domain of GR was reduced in the presence of HspBP1 but not in the presence of BAG-1M as shown by pull-down assays. Reporter gene experiments revealed an inhibitory effect on GR, MR, and AR at a wide range of HspBP1 protein levels and at hormone concentrations at or approaching saturation. BAG-1M exhibited a transition from stimulatory effects at low BAG-1M levels to inhibitory effects at higher BAG-1M levels. Overall, BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes and on receptor function with important implications for steroid receptor physiology.

  14. Propuesta de rediseño del canal "AOG" para la distribución de repuestos aeronáuticos de la Jefatura de Operaciones Logísticas de la Fuerza Aérea Colombiana

    Carlos Adrián Castro Barona

    2009-01-01

    Es necesario resaltar la necesidad de adaptar y estandarizar las Polìticas, Objetivos y Misión contemplados en el Plan Estratégico Institucional 2006-2019 de la Fuerza Aérea, orientándolos a mejorar la logística integral de las aeronaves para de esta manera cumplir adecuadamente con la prioridad de nivel uno en el alistamiento de las mismas.

  15. Ejercicio físico enfocado en trabajos de fuerza resistencia para mujeres mayores de 45 años en pro del mantenimiento de la aptitud física

    Cotacio Ávila, Luisa Fernanda

    2016-01-01

    Esta obra corresponde a la presentación de (TFI) trabajo final integrador como respuesta a la necesidad de incorporar ejercicios de fuerza resistencia en la clases de gimnasia para las mujeres mayores de 45 años en pro de mejorar la aptitud física y así poder generar un retraso en el proceso normal de envejecimiento. Facultad de Humanidades y Ciencias de la Educación

  16. Asociación entre la fuerza de las piernas y el área de sección muscular transversal del músculo cuádriceps femoral y el grado de actividad física en octogenarios

    Pedro Á. Latorre-Román

    2016-06-01

    Conclusiones. La fuerza muscular y la masa muscular del músculo cuádriceps mostraron una asociación significativa con el grado de actividad física en personas mayores. La fuerza muscular de las piernas fue un indicador útil para revelar la masa muscular y el grado de actividad física en estas personas, lo cual tiene relevancia en la práctica clínica.

  17. Ultrasmall PdmMn1-mOx binary alloyed nanoparticles on graphene catalysts for ethanol oxidation in alkaline media

    Ahmed, Mohammad Shamsuddin; Park, Dongchul; Jeon, Seungwon

    2016-03-01

    A rare combination of graphene (G)-supported palladium and manganese in mixed-oxides binary alloyed catalysts (BACs) have been synthesized with the addition of Pd and Mn metals in various ratios (G/PdmMn1-mOx) through a facile wet-chemical method and employed as an efficient anode catalyst for ethanol oxidation reaction (EOR) in alkaline fuel cells. The as prepared G/PdmMn1-mOx BACs have been characterized by several instrumental techniques; the transmission electron microscopy images show that the ultrafine alloyed nanoparticles (NPs) are excellently monodispersed onto the G. The Pd and Mn in G/PdmMn1-mOx BACs have been alloyed homogeneously, and Mn presents in mixed-oxidized form that resulted by X-ray diffraction. The electrochemical performances, kinetics and stability of these catalysts toward EOR have been evaluated using cyclic voltammetry in 1 M KOH electrolyte. Among all G/PdmMn1-mOx BACs, the G/Pd0.5Mn0.5Ox catalyst has shown much superior mass activity and incredible stability than that of pure Pd catalysts (G/Pd1Mn0Ox, Pd/C and Pt/C). The well dispersion, ultrafine size of NPs and higher degree of alloying are the key factor for enhanced and stable EOR electrocatalysis on G/Pd0.5Mn0.5Ox.

  18. La consolidación de la democracia en Nicaragua, fuerzas armadas y partidos políticos en una democracia frágil

    Secundino GONZÁLEZ

    2009-11-01

    Full Text Available RESUMEN: En el artículo se analiza la consolidación democrática en Nicaragua, destacando el importante papel desempeñado tanto por las Fuerzas Armadas como el juego de sistemas de partidos. Para el autor, estos dos elementos se mostraron plenamente funcionales para el proceso de consolidación democrática en este país. Además, sostiene que la transición a la democracia había comenzado en Nicaragua antes del proceso electoral que culminó en 1990.ABSTRACT: The article tries to analyze the democratic consolidation in Nicaragua, underlying the important role played by the Armed Forces and the party system. By the author, both of these elements have been shown very functional to the process of democratic consolidation in this country. Therefore, he sustaines also that the transition to democracy in Nicaragua had begun before the electoral process of 1990.

  19. "El ojo del amo engorda al ganado": Estrategias de control y disciplinamiento de la fuerza laboral Strategies of Control and Labor Discipline

    Nuria Inés Giniger

    2011-06-01

    Full Text Available Las empresas han debido sofisticar sus estrategias de control y disciplinamiento laboral. Para esto han conformado verdaderos Sistemas Corporativos a partir de los cuales ponen en marcha políticas empresariales tendientes a la gestión de la fuerza de trabajo y a la difusión doctrinaria. Estos Sistemas Corporativos se configuran en una relación conflictiva entre los procesos globales y locales. El proceso desarrollado por la empresa siderúrgica Acindar para la consolidación de su Sistema Corporativo permite ver de qué forma estas tensiones se expresan y el alcance de dicho sistema.The companies have had more sophisticated strategies of control and labor discipline. For this, they have made real Corporate Systems from which they develop business policies in managing the work force and dissemination of doctrine. These Corporate Systems are configured in a conflicting relationship between global and local processes. The process developed by the steel company Acindar to consolidate its Corporate System allows us to see how these tensions are expressed and the range of that system.

  20. Sobre condiciones suficientes de estabilidad para sistemas mecánicos sometidos a fuerzas dependientes de la velocidad por un método variacional

    Rodríguez Rebollo, Rafael

    1979-05-01

    Full Text Available We are considering here the stability of a mechanical system state, either discrete or continuous, subject to overall stresses, whether or not dependent on speed, having variational movement equations for small disturbances which are differential equations of the second degree in respect to time and with a formal structure, frequent in several problems of stability in continuous media and system of solid rigid particles. Stability and asymptotic stability criteria are obtained, thus generalising known results, considering self-value problems for exponential type results in respect to time.

    Consideramos la estabilidad de un estado de un sistema mecánico, discreto o continuo, sometido a fuerzas generalizadas dependientes o no de la velocidad y cuyas ecuaciones variacionales de movimiento, para pequeñas perturbaciones, son ecuaciones diferenciales de segundo orden respecto del tiempo y de una estructura formal frecuente en diversos problemas de estabilidad de medios continuos y de sistemas de partículas y de sólidos rígidos. Se obtienen criterios de estabilidad y de estabilidad asintótica y se generalizan resultados conocidos, considerando los correspondientes problemas de autovalores para soluciones de tipo exponencial respecto del tiempo.

  1. El umbral de gravedad en el crimen de agresión: ¿una nueva categoría en los usos ilícitos de la fuerza?

    Luciano Pezzano

    2016-03-01

    Full Text Available En este ensayo nos referiremos a los efectos que en las normas internacionales relativas al uso de la fuerza puede tener el denominado “umbral de gravedad” que se encuentra en la definición del crimen de agresión en el artículo 8 bis del Estatuto de Roma. Haciendo hincapié en la gravedad como característica definitoria de la agresión, buscaremos determinar si el umbral del artículo 8 bis introduce una nueva categoría dentro de los usos ilícitos de la fuerza. Para ello, analizaremos la agresión en el contexto de las normas internacionales relativas al uso de la fuerza y las disposiciones del artículo 8 bis, en particular, la cláusula de umbral, las referencias a la resolución 3314 (XXIX de la Asamblea General de las Naciones Unidas y los “entendimientos” aprobados por la Conferencia de Revisión.

  2. DETERMINACIÓN DE LOS NIVELES DE FUERZA MÁXIMA APLICADA, VELOCIDAD Y POTENCIA POR MEDIO DE UN TEST CRECIENTE EN PRES DE BANCA PLANO, EN LEVANTADORES ESPAÑOLES.

    Joaquín Figueroa Alchapar

    2010-10-01

    Full Text Available

     

    Se evaluaron 9 levantadores que realizaron 2 test en el ejercicio de pres debanca: a Progresivo con pesos ligeros a máximos (MRPr b Máxima Repetición (MRD. Semidió la fuerza (FN, velocidad (V y potencia (W con cada peso movilizado,determinándose el máximo peso factible de movilizar 1 vez y no dos (MR Se observaroncorrelaciones significativas entre la MR del test MRPr y la del MRD, la W máxima, absolutay relativa al peso corporal y la MR absoluta y relativa al peso corporal, no se produjerondiferencias significativas (p<0,05 entre la MR obtenidas en el test MRPr y MRD. Se aceptala aplicación del test MRPr para determinar los niveles de FN, V, W, y MR, localizar losniveles de W máxima, con relación al % MR, y determinar el perfil de rendimiento así comolos cambios inducidos por los entrenamientos de fuerza.

    Palabras Clave: Fuerza Máxima, Velocidad, potencia

  3. A comparative study, of 1 M and 8 M KOH electrolyte concentrations, used in Ni-MH batteries

    Khaldi, C.; Mathlouthi, H.; Lamloumi, J.

    2009-01-01

    One may wonder if we really should use a very high concentration of KOH electrolyte in Ni-MH batteries, to keep the thermodynamic and kinetic properties of the alloy, while this solution is very aggressive to the used alloys. In this work we present a comparative study, using different techniques of two concentrations, 1 M and 8 M KOH electrolytes. The maximum capacity values are 295 mAh g -1 and 237 mAh g -1 , the loss in capacity, after 23 cycles, are of 10% and 58%, the polarization after the activation are 110 mV and 360 mV and the thickness of the corrosion layer, on the electrode surface, are 7 nm and 42 nm, for the 1 M and 8 M KOH electrolytes, respectively. These results showed that replacing the solution 8 M with 1 M improves the performance of Ni-MH batteries and leads to better results

  4. [Expression optimization and characterization of Tenebrio molitor antimicrobiol peptides TmAMP1m in Escherichia coli].

    Alimu, Reyihanguli; Mao, Xinfang; Liu, Zhongyuan

    2013-06-01

    To improve the expression level of tmAMP1m gene from Tenebrio molitor in Escherichia coli, we studied the effects of expression level and activity of the fusion protein HIS-TmAMP1m by conditions, such as culture temperature, inducing time and the final concentration of inductor Isopropyl beta-D-thiogalactopyranoside (IPTG). We analyzed the optimum expression conditions by Tricine-SDS-PAGE electrophoresis, meanwhile, detected its antibacterial activity by using agarose cavity diffusion method. The results suggest that when inducing the recombinant plasmid with a final IPTG concentration of 0.1 mmol/L at 37 degrees C for 4 h, there was the highest expression level of fusion protein HIS-TmAMP1m in Escherichia coli. Under these conditions, the expression of fusion protein accounted for 40% of the total cell lysate with the best antibacterial activity. We purified the fusion protein HIS-TmAMPlm with nickel-nitrilotriacetic acid (Ni-NTA) metal-affinity chromatography matrices. Western blotting analysis indicates that the His monoclonal antibody could be specifically bound to fusion protein HIS-TmAMPlm. After expression by inducing, the fusion protein could inhibit the growth of host cell transformed by pET30a-tmAMP1m. The fusion protein HIS-TmAMP1m had better stability and remained higher antibacterial activities when incubated at 100 degrees C for 10 h, repeated freeze thawing at -20 degrees C, dissolved in strong acid and alkali, or treated by organic solvents and protease. Moreover, the minimum inhibitory concentration results demonstrated that the fusion protein HIS-TmAMP1m has a good antibacterial activity against Staphylococcus aureus, Staphylococcus sp., Corynebacterium glutamicum, Bacillus thuringiensis, Corynebacterium sp. This study laid the foundation to promote the application of insect antimicrobial peptides and further research.

  5. Limitations of the A-1M method for fecal coliform enumeration in the Pacific oyster (Crassostrea gigas).

    Kaysner, C A; Weagant, S D

    1987-01-01

    Use of the A-1M method, which was originally devised for testing water samples, has recently been extended for enumeration of fecal coliforms and Escherichia coli in shellfish and other food products. Results of our study indicate that while this method is reliable for analysis of growing waters, the use of the A-1M method for testing Pacific oysters may be less reliable because bacteria not belonging to the coliform group but which are sometimes present in these animals also give a positive reaction.

  6. Elastin-derived peptides promote abdominal aortic aneurysm formation by modulating M1/M2 macrophage polarization1

    Dale, Matthew A; Xiong, Wanfen; Carson, Jeffrey S; Suh, Melissa K; Karpisek, Andrew D.; Meisinger, Trevor M.; Casale, George P.; Baxter, B. Timothy

    2016-01-01

    Abdominal aortic aneurysm (AAA) is a dynamic vascular disease characterized by inflammatory cell invasion and extracellular matrix (ECM) degradation. Damage to elastin in the ECM results in release of elastin-derived peptides (EDPs), which are chemotactic for inflammatory cells such as monocytes. Their effect on macrophage polarization is less well known. Pro-inflammatory M1 macrophages initially are recruited to sites of injury but, if their effects are prolonged, they can lead to chronic inflammation that prevents normal tissue repair. Conversely, anti-inflammatory M2 macrophages reduce inflammation and aid in wound healing. Thus, a proper M1/M2 ratio is vital for tissue homeostasis. AAA tissue reveals a high M1/M2 ratio where pro-inflammatory cells and their associated markers dominate. In the present study, in vitro treatment of bone marrow-derived macrophages with EDPs induced M1 macrophage polarization. By using C57Bl/6 mice, antibody-mediated neutralization of EDPs reduced aortic dilation, matrix metalloproteinase activity, and pro-inflammatory cytokine expression at early and late time points after aneurysm induction. Furthermore, direct manipulation of the M1/M2 balance altered aortic dilation. Injection of M2 polarized macrophages reduced aortic dilation after aneurysm induction. EDPs promoted a pro-inflammatory environment in aortic tissue by inducing M1 polarization and neutralization of EDPs attenuated aortic dilation. The M1/M2 imbalance is vital to aneurysm formation. PMID:27183603

  7. An experimental test of the inverse square law of gravitation at range of 0.1 m

    Chen, Y.T.; Cook, A.H.; Metherell, A.J.F.

    1984-01-01

    The paper contains an account of an experimental study of departures from the inverse square law of gravitation at a range of 0.1 m both in non-null and null arrangements with geometries different from those of previous experiments of comparable precision. (author)

  8. The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys

    Andersen, Maibritt B; Fink-Jensen, Anders; Peacock, Linda

    2003-01-01

    Xanomeline is a muscarinic M(1)/M(4) preferring receptor agonist with little or no affinity for dopamine receptors. The compound reduces psychotic-like symptoms in patients with Alzheimer's disease and exhibits an antipsychotic-like profile in rodents without inducing extrapyramidal side effects ...

  9. Effects of low dose radiation on expressions of ICAM-1 mRNA and protein in kidney of diabetic mice

    Zhang Chi; Li Xiaokun; Gong Shouliang; Liu Xiaoju; Zhao Xue; Liu Xiaoju; Zhao Xue; Shen Wenjie; Li Cai; Cai Lu

    2010-01-01

    Objective: To study the effects of low dose radiation (LDR) on the expressions of intercellular adhesion molecule-1 (ICAM-1) mRNA and protein in kidney of diabetes mellitus (DM) mice and illuminate that anti-inflammation of LDR is a main mechanism for diabetic therapy. Methods: The healthy and right age C57BL/6J mice were divided into 4 groups including control, DM, LDR and DM/LDR. The mice in DM and DM/LDR groups were injected intraperitoneally with streptozocin (STZ) to set up DM models. The mice in DM/LDR and LDR groups were irradiated with 25 mGy every other day for 4 weeks. The expressions of ICAM-1 mRNA and protein in kidney were detected with RT-PCR and Western blotting 2, 4, 8, 12 and 16 weeks after irradiation. Results: The expressions of ICAM-1 mRNA and protein in kidney had no significant difference among 4 groups before LDR (P>0.05). The expressions of ICAM-1 mRNA and protein 2 weeks after irradiation with LDR were higher than those in the other 3 groups (P<0.05). The expressions of ICAM-1 mRNA and protein in the DM/LDR group 4 weeks after irradiation were also significantly higher than those in non-DM groups (P<0.05), but still significantly lower than those in DM group (P<0.05), and the significant differences were kept to 16 weeks after irradiation. But the expressions of ICAM-1 mRNA and protein in LDR group were significantly higher than those in control group (P<0.05). IHC assay showed that the glomerular and tubular in DM and DM/LDR groups were abnormal and the quantities of the positive staining cells were significantly increased compared with non-DM groups. However the damage of glomerular and tubular in DM/LDR was significantly supressed compared with DM group and the positive staining cells were also decreased. Conclusion: Under the circumstance of DM, LDR can significantly decrease the expressions of ICAM-1 mRNA and protein in mouse kidney to relief the inflammation reaction in kidney; but in normal condition, LDR can improve the immunity and

  10. El escenario de competencia de la Industria Gastronómica de Cancún basado en las cinco fuerzas de Porter.

    Damayanti Estolano Cristerna

    2013-01-01

    Full Text Available El incremento de la afluencia turística de Cancún beneficia las utilidades de los establecimientos gastronómicos, y viceversa. Este trabajo evidencia la relevancia y la relación de la industria turística y gastronómica, contribuyendo así a investigaciones más específicas sobre el sector gastronómico. El objetivo de esta investigación fue describir el escenario de competencia de los últimos tres años con base en las Cinco Fuerzas que forman la estrategia de Michael Porter, diseñando una investigación no experimental descriptiva, que consistió principalmente en la consulta documental y de fuentes electrónicas, trabajo de campo y entrevistas. Los resultados obtenidos mostraron que: el crecimiento de los nuevos participantes es bajo; los clubes de precio están sustituyendo a los proveedores de materia prima; los compradores residentes son los más sensibles al precio; los productos sustitutos satisfacen la necesidad de alimentación a través de tiendas de conveniencia; los competidores se ven afectados por la existencia de los hoteles Todo Incluido en la Zona Hotelera y el comercio informal y/o ambulante en la Zona Centro. Con esta investigación se aplicó una teoría con abundante evidencia empírica en la relevante industria gastronómica de Cancún, obteniendo como resultado un producto para los investigadores y actores de la industria.

  11. Effects of fuelling by using high-pressure supersonic molecular beam in the HL-1M tokamak

    Yao Lianghua; Feng Beibin; Feng Zhen; Dong Jiafu; Li Wenzhong; Xu Deming; Hong Wenyu

    2002-01-01

    Supersonic molecular beam (SMB), as a new fuelling method, has been successfully developed and used in HL-1M tokamak and HT-7 superconducting tokamak. The hydrogen clusters have been found in the beam produced by high working-gas pressure in recent experiments. With a penetration depth of hydrogen particles greater than 17 cm, the rate of increase of electron density for SMB injection, dn e -bar/dt, approaches that of the small ice pellet injection. The plasma density increases step by step after multi-pulse SMB injection, just as multi-pellet fuelling. Comparison of fuelling effects was made between SMB and ice pellet injection on the same shot of ohmic discharge in HL-1M

  12. Evidence for a common scale O(0.1) m that controls seabed scattering and reverberation in shallow water.

    Holland, Charles W

    2012-10-01

    Analysis of the spectral content of long-range reverberation yields two observations. First, there is a remarkably similar scale, O(0.1) m, between three diverse continental shelf regions. This is surprising given the complexity and diversity of geologic processes. Second, there is strong evidence that the scale is associated with heterogeneities within the sediment. Thus, sediment volume scattering, not interface scattering, controls long-range reverberation from a few hundred hertz to several kilohertz. This is also unexpected given that at long ranges the vertical grazing angles are less than the critical angle, and hence the penetration of the acoustic field into the sub-bottom is expected to be modest. The consistency of the scale, O(0.1) m, suggests an underlying feature or mechanism that is consistent across many ostensibly diverse geological settings. Neither the feature nor mechanism is known at this time.

  13. county_1m

    Federal Emergency Management Agency, Department of Homeland Security — This is a raster grid dataset (1-Meter Resolution) of the ground points derived from the acquired LiDAR. The Light Detection and Ranging (LiDAR) DEM dataset is a...

  14. Clinical significance of serum circulating insulin-like growth factor-1 (IGF-1) mRNA in hepatocellular carcinoma.

    Karabulut, S; Duranyıldız, D; Tas, F; Gezer, U; Akyüz, F; Serilmez, M; Ozgür, E; Yasasever, C T; Vatansever, S; Aykan, N F

    2014-03-01

    The principal aim of our study was to investigate the usefulness of serum protein and circulating mRNA of insulin-like growth factor-1 (IGF-1) as a diagnostic and prognostic tool in hepatocellular carcinoma (HCC). Fifty-four HCC patients and age- and sex-matched 20 healthy controls were enrolled into this study. Pretreatment serum IGF-1 and IGF-1 mRNA were determined by the solid-phase sandwich ELISA and quantitative RT-PCR method, respectively. The median age at diagnosis was 60 years, range 36-77 years; where majority of group were male (n = 48, 88.8%). All patients had cirrhotic history. Forty-six percent (n = 25) of patients had Child-Pugh score A, 30% (n = 16) had score B or C. All of the patients were treated with local therapies and none of them received sorafenib. The baseline serum IGF-1 mRNA levels were significantly higher in HCC patients than in the control group (p = 0.04), whereas no significant difference was observed for IGF-1 protein levels between the two group (p = 0.18). Patients with history of HBV infection, who were not treated, and who received multiple palliative treatment for HCC had higher serum IGF-1 mRNA levels (p = 0.03, 0.03, and 0.05, respectively). Poor performance status (p IGF-1 nor serum IGF-1 mRNA had significantly adverse effect on survival (p = 0.53 and 0.42, respectively).

  15. How well do we know the quantum numbers of possible anti p p → M1M2 states

    Lanou, R.E.

    1979-01-01

    Information is available to completely analyze the p anti p → ππ reaction, allowing more global, large-scale, phenomenological analyses which combine the two experimental data sets in an energy independent, amplitude analysis which also includes pion-nucleon data. It would appear from the preliminary analyses of p anti p → M 1 M 2 angular distributions and polarizations the T-region may indeed contain some very interesting activity

  16. The Impact of Ramadan Fasting on SIRT1 mRNA Expression in Peripheral Blood Mononuclear Cells

    Mostafa Haji Molahoseini; kanaan Gorjipour; Farshid Yeganeh

    2016-01-01

    Background:The aim of this study was to evaluate the effect of Ramadan fasting on SIRT1 mRNA expression in healthy men.Islamic Ramadan fasting is a holy religious ceremony that has many spiritual benefits. Additionally, it can be considered as the equivalent of calorie restriction that may affect physical health. The results of previous studies revealed that calorie restriction increases the lifespan in laboratory rodents via increasing the expression of a histone deacetylase named SIRT1. Add...

  17. Activated carbon and single-walled carbon nanotube based electrochemical capacitor in 1 M LiPF6 electrolyte

    Azam, M.A.; Jantan, N.H.; Dorah, N.; Seman, R.N.A.R.; Manaf, N.S.A.; Kudin, T.I.T.; Yahya, M.Z.A.

    2015-01-01

    Highlights: • Activated carbon and single-walled CNT based electrochemical capacitor. • Electrochemical analysis by means of CV, charge/discharge and impedance. • 1 M LiPF 6 non-aqueous solution as an electrolyte. • AC/SWCNT electrode exhibits a maximum capacitance of 60.97 F g −1 . - Abstract: Carbon nanotubes have been extensively studied because of their wide range of potential application such as in nanoscale electric circuits, textiles, transportation, health, and the environment. Carbon nanotubes feature extraordinary properties, such as electrical conductivities higher than those of copper, hardness and thermal conductivity higher than those of diamond, and strength surpassing that of steel, among others. This research focuses on the fabrication of an energy storage device, namely, an electrochemical capacitor, by using carbon materials, i.e., activated carbon and single-walled carbon nanotubes, of a specific weight ratio as electrode materials. The electrolyte functioning as an ion carrier is 1 M lithium hexafluorophosphate. Variations in the electrochemical performance of the device, including its capacitance, charge/discharge characteristics, and impedance, are reported in this paper. The electrode proposed in this work exhibits a maximum capacitance of 60.97 F g −1 at a scan rate of 1 mV s −1

  18. The Impact of Ramadan Fasting on SIRT1 mRNA Expression in Peripheral Blood Mononuclear Cells

    Mostafa Haji Molahoseini

    2016-11-01

    Full Text Available Background:The aim of this study was to evaluate the effect of Ramadan fasting on SIRT1 mRNA expression in healthy men.Islamic Ramadan fasting is a holy religious ceremony that has many spiritual benefits. Additionally, it can be considered as the equivalent of calorie restriction that may affect physical health. The results of previous studies revealed that calorie restriction increases the lifespan in laboratory rodents via increasing the expression of a histone deacetylase named SIRT1. Additionally, SIRT1 is known for its anti-inflammatory properties. Materials and Methods: Overall, 43 men volunteered for participating in this one-group before and after (self-controlled study. Two mL blood samples were taken prior to fasting and at the end of the 30th day of fasting. Routine biochemical tests and SIRT1 mRNA expression analysis were performed. Results: Cholesterol and low-density lipoproteins increase, however, high-density lipoproteins level decreased after Ramadan fasting. The analysis of real-time PCR results revealed that SIRT1 mRNA expression in human peripheral blood mononuclear cells increased 4.63 fold in fasting state in comparison with non-fasting state. Conclusion: Ramadan fasting has a significant effect on SIRT1 gene expression. Considering the immunosuppressive and anti-inflammatory properties of SIRT1, further studies are needed to evaluate the effects of SIRT1 up-regulation on the autoimmune and inflammatory diseases during Ramadan fasting.

  19. A comparison of the Actigraph GT1M and GT3X accelerometers under standardized and free-living conditions

    Kaminsky, Leonard A; Ozemek, Cemal

    2012-01-01

    Prior to 2008, data collection from Actigraph accelerometers was only possible in the uniaxial mode. In 2009, Actigraph released the GT3X, which allows triaxial data collection. The purpose of this study was to determine if data collected by the GT3X in the uniaxial mode are comparable to its predecessor, the GT1M, under both standardized and free-living conditions. Thirty-four subjects (17 women and 17 men) provided complete data for this study. Subjects wore the accelerometers (one GT1M and one GT3X) on their waistband in line with the right and left anterior axillary lines. Each subject walked on a treadmill at speeds of 2.4, 3.2, 4.0, 4.8, 5.6 and 6.4 km h −1 for 5 min each, and then continued to wear both accelerometers for all waking hours for three consecutive days. Mean steady-state activity counts min –1 for both accelerometers were not statistically different for the standardized treadmill walking speeds and for mean minutes/day and activity counts/day for intensity classifications under the free-living condition. Based on comparisons made from both standardized walking speeds and free-living conditions, it is reasonable to compare data derived from either the GT1M or GT3X when collected in the uniaxial mode. (paper)

  20. Operation of TRR-1/M1 for 25 years and lessons learned in management of safety and safety culture

    Keinmeesuke, Sirichai

    2002-01-01

    The first Thai Research Reactor, TRR-1, was installed and put into operation in 1962. In 1975 the reactor was converted to a 2 MW TRIGA Mark III by replacing of the reactor core and the control system. The renamed TRR-1/M1 research reactor went critical again in November 1977. TRR-1/M1 has been operated safely for 25 years with its main utilization in research, isotope production and training. Safety management and safety culture have been implemented for 25 years both in the legislation level and the operation level. There was no nuclear incident and there were a few radiological incidents during the 25 years of operation of TRR-1/M1. The lessons learned from the incident events such as the release of N-16 and Ar-41, the release of radioactive Bromine gave valued opportunities to improve our operation procedure, safety procedure and safety culture. All type of activities with respect to safety culture such as individual awareness, commitment, motivation, supervision and responsibility have been seriously reviewed and being set as normal practices. (author)

  1. Activated carbon and single-walled carbon nanotube based electrochemical capacitor in 1 M LiPF{sub 6} electrolyte

    Azam, M.A., E-mail: asyadi@utem.edu.my [Carbon Research Technology Research Group, Faculty of Manufacturing Engineering, Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, 76100 Durian Tunggal, Melaka (Malaysia); Jantan, N.H.; Dorah, N.; Seman, R.N.A.R.; Manaf, N.S.A. [Carbon Research Technology Research Group, Faculty of Manufacturing Engineering, Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, 76100 Durian Tunggal, Melaka (Malaysia); Kudin, T.I.T. [Ionics Materials & Devices Research Laboratory, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor (Malaysia); Yahya, M.Z.A. [Ionics Materials & Devices Research Laboratory, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor (Malaysia); National Defence University of Malaysia, Kem Sungai Besi, 57000 Kuala Lumpur (Malaysia)

    2015-09-15

    Highlights: • Activated carbon and single-walled CNT based electrochemical capacitor. • Electrochemical analysis by means of CV, charge/discharge and impedance. • 1 M LiPF{sub 6} non-aqueous solution as an electrolyte. • AC/SWCNT electrode exhibits a maximum capacitance of 60.97 F g{sup −1}. - Abstract: Carbon nanotubes have been extensively studied because of their wide range of potential application such as in nanoscale electric circuits, textiles, transportation, health, and the environment. Carbon nanotubes feature extraordinary properties, such as electrical conductivities higher than those of copper, hardness and thermal conductivity higher than those of diamond, and strength surpassing that of steel, among others. This research focuses on the fabrication of an energy storage device, namely, an electrochemical capacitor, by using carbon materials, i.e., activated carbon and single-walled carbon nanotubes, of a specific weight ratio as electrode materials. The electrolyte functioning as an ion carrier is 1 M lithium hexafluorophosphate. Variations in the electrochemical performance of the device, including its capacitance, charge/discharge characteristics, and impedance, are reported in this paper. The electrode proposed in this work exhibits a maximum capacitance of 60.97 F g{sup −1} at a scan rate of 1 mV s{sup −1}.

  2. Decreases in Casz1 mRNA by an siRNA Complex Do not Alter Blood Pressure in Mice.

    Ji, Su-Min; Shin, Young-Bin; Park, So-Yon; Lee, Hyeon-Ju; Oh, Bermseok

    2012-03-01

    Recent genomewide association studies of large samples have identified genes that are associated with blood pressure. The Global Blood Pressure Genetics (Global BPgen) and Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) consortiums identified 14 loci that govern blood pressure on a genomewide significance level, one of which is CASZ1 confirmed in both Europeans and Asians. CASZ1 is a zinc finger transcription factor that controls apoptosis and cell fate and suppresses neuroblastoma tumor growth by reprogramming gene expression, like a tumor suppressor. To validate the function of CASZ1 in blood pressure, we decreased Casz1 mRNA levels in mice by siRNA. Casz1 siRNA reduced mRNA levels by 59% in a mouse cell line. A polyethylenimine-mixed siRNA complex was injected into mouse tail veins, reducing Casz1 mRNA expression to 45% in the kidney. However, blood pressure in the treated mice was unaffected, despite a 55% reduction in Casz1 mRNA levels in the kidney on multiple siRNA injections daily. Even though Casz1 siRNA-treated mice did not experience any significant change in blood pressure, our study demonstrates the value of in vivo siRNA injection in analyzing the function of candidate genes identified by genomewide association studies.

  3. In vitro detection of mdr1 mRNA in murine leukemia cells with 111In-labeled oligonucleotide

    Bai Jingming; Yokoyama, Kunihiko; Kinuya, Seigo; Michigishi, Takatoshi; Tonami, Norihisa; Shiba, Kazuhiro; Matsushita, Ryo; Nomura, Masaaki

    2004-01-01

    The feasibility of intracellular mdr1 mRNA expression detection with radiolabeled antisense oligonucleotide (ODN) was investigated in the murine leukemia cell line, P388/S, and its subclonal, adriamycin-resistant cell line, P388/R. The expression level of mdr1 mRNA was analyzed by reverse transcription-polymerase chain reaction (RT-PCR). Existence of the multidrug resistance (MDR) phenomenon was assessed via cellular uptake of 99m Tc-sestamibi (MIBI), a known substrate for P-glycoprotein. A 15-mer phosphorothioate antisense ODN complementary to the sequences located at -1 to 14 of mdr1 mRNA and its corresponding sense ODN were conjugated with the cyclic anhydride of diethylene triamine penta-acetic acid (cDTPA) via an amino group linked to the terminal phosphate at the 5' end at pH 8-9. The DTPA-ODN complexes at concentrations of 0.1-17.4 μMwere reacted with 111 InCl 3 at pH 5 for 1 h. The hybridization affinity of labeled ODN was evaluated with size-exclusion high-performance liquid chromatography following incubation with the complementary sequence. Cellular uptake of labeled ODN was examined in vitro. Furthermore, enhancing effects of synthetic lipid carriers (Transfast) on transmembrane delivery of ODN were assessed. P388/R cells displayed intense mdr1 mRNA expression in comparison with P388/S cells. 99m Tc-MIBI uptake in P388/S cells was higher than that in P388/R cells. Specific radioactivity up to 1,634 MBq/nmol was achieved via elevation of added radioactivity relative to ODN molar amount. The hybridization affinity of antisense 111 In-ODN was preserved at approximately 85% irrespective of specific activity. Cellular uptake of antisense 111 In-ODN did not differ from that of sense 111 In-ODN in either P388/S cells or P388/R cells. However, lipid carrier incorporation significantly increased transmembrane delivery of 111 In-ODN; moreover, specific uptake of antisense 111 In-ODN was demonstrated in P388/R cells. Radiolabeling of ODN at high specific

  4. Effects of short term training using resistance maximal workloads in futsal players and cyclist Respuesta a corto plazo al entrenamiento de fuerza máxima en jugadores de fútbol sala y ciclistas

    J.M. Garcia

    2010-09-01

    Full Text Available The purpose of this study is to elucidate the effects of high intensity-strength training (S in two consecutive days in different athletes. 20 subjects divided in two groups: 11 futsal players of semiprofessional level (FG (22,5±1,4 yr and 9 endurance trained athletes of national level (EG (21±1,3 yr. The intervention was composed by two training sessions (4 sets of 3 repetitions at 8590% of their 1RM in the squat exercise separated by 24h. Two days before the first workout and 9 days after the second workout subjects were measured for 1RM in squat (90 knee angle. Tests: 1 Maximum Repetition in half-squat exercise. Variables: weight in one maximum repetititum (kg; Force (N; and power (w. Instrument: MicromuscleLab Power (ergotest technology as-Norway. The results showed increasing in 1MR in weight (p<0.05, force production ((p<0.05 but didn’t showed significant differences in power output in 1MR It was concluded that acute effects of high intensity strength training using this protocol is advantageous for increasing force production in futsal players and cyclists.

    Key Words:short term effect, strength, power, training program

     

    El objetivo del estudio es conocer los efectos sobre la fuerza máxima y la potencia en 1 repetición máxima (RM de un programa de entrenamiento de fuerza usando cargas máximas en jugadores de fútbol-sala y ciclistas. 20 hombres divididos en 2 grupos: 11 jugadores de fútbol-sala semiprofesionales (21±1,3 años, y 9 ciclistas de ruta de categoría nacional (22,5±1,4 años participaron en la investigación. El programa de entrenamiento fue 2 sesiones (4 series de 3 repeticiones al 85-90% de 1RM, con 3-5 min de descanso entre series, con la máxima velocidad de ejecución posible, posteriormente descansaban 9 días repitiéndose de nuevo este trabajo. Se determinó a través del test 1RM en

  5. Troquel sensorizado para el estudio de las principales fuerzas que intervienen en el proceso de embutición. // Sensitivity Die for the study of the main forces in the rivet process.

    L. A. Valdivia Pérez

    2006-05-01

    Full Text Available El control de las fuerzas que intervienen en el desarrollo del embutido, así como también en la generación de la fuerza defricción, es una vía para lograr la disminución de los defectos en las piezas y minimizar la fricción. Mediante el empleo dela electrónica moderna y las técnicas de sensorización, como complemento necesario, puede obtenerse un control integraldel proceso.En el presente trabajo se muestra el proceso de diseño y selección de los componentes de un sistema de regulación ycontrol para un troquel que ha sido diseñado y construido con el objetivo de conocer el comportamiento de las principalesfuerzas que intervienen en el proceso de embutición. Como elementos de medición y control de los parámetros del procesose utilizan diversos tipos de sensores o captadores.Palabras claves: Control de fuerzas en el embutido, troquel sensorizado, sistema de control, captador, fricción ydesgaste en troqueles.____________________________________________________________________________Abstract.The control of forces that intervene in the development of the deep drawing process, as well as in the generation of thefriction force it is a way to achieve the decrease of defects in spares, and to minimize friction.The present paper deals with the process of design and selection of components of the regulation and control system for adie designed and build for the analysis of the principal forces in the deep drawing process. Different types of sensors orcollectors have been used in order to allow the control and the measurement of parameters.Keywords: Deep drawing process, control system, captator, friction and wear in die.

  6. Determination of curve 1/M profile as a function of control rod bank position; Determinacao do perfil da curva 1/M em funcao da posicao dos bancos de barras de controle

    Pereira, Valmir; Martinez, Aquilino Senra; Silva, Fernando Carvalho da [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Programa de Engenharia Nuclear

    2002-07-01

    Determination of the subcritical multiplication curve profile (1/M) as a function of control rod bank position is of paramount importance to the development of a system which allows to foresee and also anticipate determination of criticality of a PWR reactor core. This work aims at determining this profile. For that, the 3D- two group-diffusion equations for a subcritical PWR reactor core with external neutron source is solved for different control rod bank positions. Results obtained are compared with the results from the corresponding eigenvalue problem, in order to verify how the external neutron source interferes with the reactor criticality search. (author)

  7. Factores que influyen en la aceptabilidad del uso de la vasectomía como estrategia para la disminución de embarazos no deseados por parte de miembros de las Fuerzas Militares de Colombia

    Vidal Rivera, Yuly Anjelica; Garzón Cortes, Karen Irene

    2013-01-01

    Este trabajo de tesis se realizó con el objetivo de conocer y determinar, los factores que influyen en la aceptabilidad del uso de la vasectomía, como estrategia para la disminución de embarazos no deseados por parte de miembros de las Fuerzas Armadas de Colombia, buscando una estrategia adecuada para reducir costos del sistema de sanidad militar. Se realizo un estudio de tipo exploratorio - descriptivo con enfoque cuantitativo, en busca de identificar las causas de la baja participación ...

  8. Calidad de vida y cáncer de próstata: un programa progresivo de fuerza-resistencia = Quality of life and prostate cancer: a progressive resistance strength program

    Serdà Ferrer, Bernat-Carles; Monreal i Bosch, Pilar; Valle Gómez, Arantza del

    2011-01-01

    Este artículo presenta el diseño y la implementación de un programa progresivo de fuerza-resistencia adaptado al cáncer de próstata. El modelo base corresponde a la guía de la American College Sports Medicine Position Stand (ACSM, 2009). La adaptación y transformación del programa incluye los síntomas más habituales relativos a la enfermedad y sus tratamientos. El diseño del estudio es cuasiexperimental. La muestra es de 33 participantes en fase de tratamiento. Las variables de estudio so...

  9. Revisión del efecto del entrenamiento de la fuerza sobre el rendimiento de la resistencia y variables asociadas en distintas disciplinas (ciclismo, pedestrismo, triatlón, etc.)

    Cragnulini, Franco Emmanuel

    2015-01-01

    El propósito de la presente revisión será analizar los resultados de distintas investigaciones en relación al tema mencionado con anterioridad y arribar a una conclusión que permita acercarnos a una respuesta de si resulta beneficioso o contraproducente acoplar el entrenamiento de la fuerza al programa de entrenamiento de la resistencia en deportes cíclicos (ciclismo, pedestrismo, triatlón, etc). El entrenamiento de la resistencia disminuye la actividad de las enzimas glucolítica...

  10. Valoración "in vitro" de las fuerzas de adhesión de un sistema adhesivo convencional y otro autograbante en esmalte de dientes temporales y permanentes

    Herrera Martínez, Gilberto de Jesús

    2012-01-01

    El presente trabajo trata de aportar más información sobre un nuevo adhesivo autograbante a esmalte de dientes temporales y permanentes. El objetivo es valorar las fuerzas de adhesión en MPa de los sistemas adhesivos (convencional y autograbante),en el esmalte de dientes temporales y permanentes. Métodos: utilizando una muestra de 160 dientes (temporales y permanentes)a nivel de la estructura del esmalte, divididos en cuatro grupos, no tomándose en cuenta para el criterio de selección la p...

  11. Relación del peso máximo con la fuerza aplicada y la potencia producida en un test creciente, en el ejercicio de press de banca plano con barra libre, en levantadores

    Naclerio Ayllón, Fernando; Jiménez Gutiérrez, Alfonso; Forte Fernández, Daniel; Benito Peinado, Pedro J.

    2006-01-01

    Se evaluaron 9 levantadores que realizaron 2 test, en el ejercicio de press de banca plano con barra libre. Un test progresivo con pesos ligeros a máximos (TPR), y el test de una máxima repetición (1 MRD). Se midió la fuerza (f), velocidad (v) y potencia (p) con cada peso movilizado, se determinó el máximo peso desplazado en una única repetición (1 MR). Se observaron correlaciones significativas entre el valor de la 1 MR obtenida en el test de 1 MRPr y el de 1 MRD, entre la potencia máxima (a...

  12. Riesgos físicos y efectos en la salud del personal de enfermería, que labora en el centro quirúrgico del Hospital de Especialidades Fuerzas Armadas, periodo Marzo 2010 a Marzo 2011

    Montes Hinojosa, Freddy Patricio

    2014-01-01

    El presente estudio se fundamentó, en la investigación bibliográfica y de campo, El tipo de investigación es descriptiva y transversal, se utilizó para la recolección de datos la técnica de la encuesta, con la aplicación de un cuestionario. La población de estudio comprende de 30 talentos humanos, 16 Enfermeras/os y 14 auxiliares e instrumentistas de enfermería que labora en la Sala de Operaciones del Hospital de Especialidades Fuerzas Armadas. La naturaleza del trabajo de enfermería expone a...

  13. Influencia de la masa corporal y de la distribución grasa sobre la fuerza muscular de una cohorte de población anciana: Diferencias por sexo

    Castillo Gallego, Carmen

    2015-01-01

    Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura 18-09-2015 Objetivo: La grasa visceral tiene una alta actividad metabólica con efectos deletéreos para la salud. Entre los efectos adversos contra la salud está el aumento del riesgo de fragilidad. Una parte importante de la fragilidad en el anciano es la sarcopenia o pérdida de masa y de fuerza muscular que se produce con la edad. En esta tesis do...

  14. Valoración de la influencia de la práctica del fútbol en la evolución de la fuerza, la flexibilidad y la velocidad en población infantil

    Silvia Sedano Campo*; Gonzalo Cuadrado Sáenz; uan Carlos Redondo Castán

    2007-01-01

    El objetivo del estudio es valorar la influencia que la práctica regular del fútbol tiene sobre algunos aspectos de la condición física (fuerza explosiva del tren inferior, flexibilidad y velocidad) en niños de entre 7 y 14 años. Por otro lado también pretendemos determinar la correlación existente entre las tres capacidades evaluadas, comparar los resultados con población infantil general y analizar las posibles influencias que la práctica de este deporte puede tener en el desarrollo evoluti...

  15. Política pública sobre capacitación y empleo en Chile: Inclusión/exclusión de una fuerza laboral que envejece

    Gray, Nora; Basualto, Cynthia; Sisto, Vicente

    2017-01-01

    Resumen: Nuestra sociedad está envejeciendo, muchas personas se verán obligados a trabajar hasta avanzada edad. Desde el punto de vista laboral, se requieren de políticas públicas inclusivas de la fuerza laboral a medida que envejece ofreciendo oportunidades de capacitación y fomento del empleo. Este estudio exploratorio analizó la oferta de los programas vigentes del Servicio Nacional de Capacitación y Empleo respecto a si promueven o no la inclusión de trabajadores mayores. Se realizó una c...

  16. Desarrollo de la fuerza en la lucha olímpica categoría cadetes 15-17 años de la Selección del Azuay

    Guerrero García, René Santiago; Tapia Paredes, Bolívar Alfonso

    2011-01-01

    Los orígenes de la lucha se han dado desde la aparición del hombre ya que se viene dando en competencias desde las primeras olimpiadas antiguas y modernas. En nuestro país la lucha como tal se introduce a mediados del siglo pasado en ciudades como Quito y Guayaquil que son las pioneras de esta disciplina, y a la ciudad de Cuenca se introduce en los años setenta. Los métodos utilizados para el desarrollo de la fuerza son los Generales y Específicos. La característica de esta cualidad fí...

  17. Masa muscular, fuerza isométrica y dinámica en las extremidades inferiores de niños y adolescentes con síndrome de Down

    González-Agüero, A.; Villarroya, M.A.; Vicente-Rodríguez, G.; Casajús, J.A.

    2009-01-01

    En general se ha observado que las personas con síndrome de Down (SD) tienen valores inferiores de fuerza muscular comparados con personas sin SD. También existe un déficit de masa muscular en los adultos con SD comparados con otros sin SD. Sin embargo, ningún estudio hasta la fecha había evaluado esta masa muscular en población pediátrica. Nuestro estudio pretende poner de manifiesto si también a edades tempranas existe un déficit de masa muscular y además relacionar ambos valores. Los niños...

  18. Fuerzas concurrentes en la conformación de la identidad profesional de los psicólogos Concurrent powers to build up the professional identity of psychologists

    Ana Diamant

    2006-12-01

    Full Text Available Se propone la recuperación de una historia de creencias, valores y representaciones de estudiantes y docentes de Psicología de la UBA, en relación a la consolidación del perfil académico y profesional de los graduados y a los actores y fuerzas que operaron en los primeros tiempos que suceden a la creación de la carrera. Para su elaboración se atendieron cuestiones vinculadas a las características de •el contenido: una versión del pasado, atravesada por el tiempo y condicionada por la posición que protagonistas y testigos ocuparon o que se les atribuyen. •lo metodológico: las maniobras para la consolidación, interpelación e interpretación de fuentes. •los escenarios donde se desplegaron las acciones. las actuaciones tanto individuales como grupales y a las relaciones establecidas. •el sello que dejaron los primeros maestros y protagonistas reconocidos al tiempo que se ocupaban los espacios de formación, inserción profesional y gremial.The purpose is the recovery of a history of beliefs, values and representations of students and professors of the course of studies of psychology at UBA which might be related with the graduates' professional and academic profile and with the protagonists and powers that influenced it at the beginning of the course of studies. In order to do so, we took into account all those matters related to the following: •Content: a version of the past, influenced by time and conditioned by the role protagonists and witnesses played or the one that was granted to them. •Methodology: maneuvers for the consolidation, questioning and interpretation of sources. •The scenes where the events occurred. Individual and team roles and the relationships among them. •The hallmarks of the first recognized professors and protagonists when dealing with training, professional and guild inclusion spaces.

  19. Neurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment.

    Lum, Jeremy S; Fernandez, Francesca; Matosin, Natalie; Andrews, Jessica L; Huang, Xu-Feng; Ooi, Lezanne; Newell, Kelly A

    2016-10-10

    Group 1 metabotropic glutamate receptors (mGluR1/mGluR5) play an integral role in neurodevelopment and are implicated in psychiatric disorders, such as schizophrenia. mGluR1 and mGluR5 are expressed as homodimers, which is important for their functionality and pharmacology. We examined the protein expression of dimeric and monomeric mGluR1α and mGluR5 in the prefrontal cortex (PFC) and hippocampus throughout development (juvenile/adolescence/adulthood) and in the perinatal phencyclidine (PCP) model of schizophrenia. Under control conditions, mGluR1α dimer expression increased between juvenile and adolescence (209-328%), while monomeric levels remained consistent. Dimeric mGluR5 was steadily expressed across all time points; monomeric mGluR5 was present in juveniles, dramatically declining at adolescence and adulthood (-97-99%). The mGluR regulators, Homer 1b/c and Norbin, significantly increased with age in the PFC and hippocampus. Perinatal PCP treatment significantly increased juvenile dimeric mGluR5 levels in the PFC and hippocampus (37-50%) but decreased hippocampal mGluR1α (-50-56%). Perinatal PCP treatment also reduced mGluR1α dimer levels in the PFC at adulthood (-31%). These results suggest that Group 1 mGluRs have distinct dimeric and monomeric neurodevelopmental patterns, which may impact their pharmacological profiles at specific ages. Perinatal PCP treatment disrupted the early expression of Group 1 mGluRs which may underlie neurodevelopmental alterations observed in this model.

  20. Occupational Toluene Exposure Induces Cytochrome P450 2E1 mRNA Expression in Peripheral Lymphocytes

    Mendoza-Cantú, Ania; Castorena-Torres, Fabiola; de León, Mario Bermúdez; Cisneros, Bulmaro; López-Carrillo, Lizbeth; Rojas-García, Aurora E.; Aguilar-Salinas, Alberto; Manno, Maurizio; Albores, Arnulfo

    2006-01-01

    Print workers are exposed to organic solvents, of which the systemic toxicant toluene is a main component. Toluene induces expression of cytochrome P450 2E1 (CYP2E1), an enzyme involved in its own metabolism and that of other protoxicants, including some procarcinogens. Therefore, we investigated the association between toluene exposure and the CYP2E1 response, as assessed by mRNA content in peripheral lymphocytes or the 6-hydroxychlorzoxazone (6OH-CHZ)/chlorzoxazone (CHZ) quotient (known as CHZ metabolic ratio) in plasma, and the role of genotype (5′-flanking region RsaI/PstI polymorphic sites) in 97 male print workers. The geometric mean (GM) of toluene concentration in the air was 52.80 ppm (10–760 ppm); 54% of the study participants were exposed to toluene concentrations that exceeded the maximum permissible exposure level (MPEL). The GM of urinary hippuric acid at the end of a work shift (0.041 g/g creatinine) was elevated relative to that before the shift (0.027 g/g creatinine; p < 0.05). The GM of the CHZ metabolic ratio was 0.33 (0–9.3), with 40% of the subjects having ratios below the GM. However, the average CYP2E1 mRNA level in peripheral lymphocytes was 1.07 (0.30–3.08), and CYP2E1 mRNA levels within subjects correlated with the toluene exposure ratio (environmental toluene concentration:urinary hippuric acid concentration) (p = 0.014). Genotype did not alter the association between the toluene exposure ratio and mRNA content. In summary, with further validation, CYP2E1 mRNA content in peripheral lymphocytes could be a sensitive and noninvasive biomarker for the continuous monitoring of toluene effects in exposed persons. PMID:16581535

  1. [Expression and significance of P-gp/mdr1 mRNA, MRP and LRP in non-Hodgkin's lymphoma].

    Li, Le; Su, Li-ping; Ma, Li; Zhao, Jin; Zhu, Lei; Zhou, Yong-an

    2009-03-01

    To explore the expression and clinical significance of P-glycoprotein (P-gp)/mdr1mRNA, multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) in newly diagnosed non-Hodgkin's lymphoma. mdr1 mRNA of in 41 patients with non-Hodgkin's lymphoma was assayed by semi-quantitative RT-PCR. The expressions of P-gp, MRP and LRP proteins in lymph node viable blasts were identified by flow cytometry. The results were compared with those obtained from control cases, and the correlation of the changes with clinical outcomes was analyzed. (1) Among the 41 cases, the positive expression of P-gp protein was detected in 8 cases, MRP in 7 cases, LRP in 15 cases, and mdr 1 mRNA in 11 cases. (2) The P-gp and LRP levels in NHL were significantly higher than those in control group, but MRP wasn't. The P-gp over-expression was significantly associated with mdr1mRNA (r = 0.396, P = 0.01). No correlation was showed among the expressions of P-gp, MRP and LRP. (3) Patients with P-gp expression had a poorer outcome of chemotherapy than those with P-gp-negative (P = 0.005). P-gp expression was significantly associated with higher clinical stage (P = 0.046) and elevated serum lactate dehydrogenase level (P = 0.032), but not associated with malignant degree (P = 0.298). MRP had no impact on the outcome of chemotherapy (P = 0.212), and wasn't significantly associated with higher clinical stage (P = 0.369), elevated LDH (P = 0.762) and higher malignant degree (P = 0.451). Patients with LRP expression had a poorer outcome of chemotherapy than those LRP-negative (P = 0.012). LRP expression was significantly associated with higher clinical stage (P = 0.0019), elevated LDH (P = 0.02) and higher malignant degree (P = 0.01). The data of this study indicate that P-gp and LRP expressions but not MRP expression are important in the mechanism of drug resistance associated with a poor clinical outcome in previously untreated NHL.

  2. Identification of alternatively spliced TIMP-1 mRNA in cancer cell lines and colon cancer tissue

    Usher, Pernille Autzen; Sieuwerts, A.M.; Bartels, Annette

    2007-01-01

    TIMP-1 is a promising new candidate as a prognostic marker in colorectal and breast cancer. We now describe the discovery of two alternatively spliced variants of TIMP-1 mRNA. The two variants lacking exon 2 (del-2) and 5 (del-5), respectively, were identified in human cancer cell lines by RT......-PCR. The del-2 variant was, furthermore, detected in extracts from 12 colorectal cancer tissue samples. By western blotting additional bands of lower molecular mass than full-length TIMP-1 were identified in tumor tissue, but not in plasma samples obtained from cancer patients. The two splice variants of TIMP...

  3. Fabrication and Test of a 1 m Long Single-Aperture 11 T Nb$_3$Sn Dipole for LHC Upgrades

    Zlobin, A. V. [Fermilab; Andreev, N. [Fermilab; Apollinari, G. [Fermilab; Barzi, E. [Fermilab; Bossert, R. [Fermilab; Chlachidze, G. [Fermilab; DiMarco, J. [Fermilab; Nobrega, F. [Fermilab; Novitski, I. [Fermilab; Turrioni, D. [Fermilab; Velev, G. [Fermilab; Auchmann, B. [CERN; Karppinen, M. [CERN; Rossi, L. [CERN; Smekens, D. [CERN

    2013-06-01

    FNAL and CERN are carrying out a joint R&D program with the goal of building a 5.5-m long twin-aperture Nb$_3$Sn dipole prototype suitable for installation in the LHC. An important part of the program is the development and test of a series of short single-aperture demonstration dipoles with a nominal field of 11 T at the LHC nominal current of 11.85 kA and 20% margin. This paper describes design features and test results of a 1 m long single-aperture Nb3Sn demonstrator dipole.

  4. The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys

    Andersen, Maibritt B; Fink-Jensen, Anders; Peacock, Linda

    2003-01-01

    (EPS) at therapeutically relevant doses. In the present study, we examined whether the xanomeline-induced functional dopamine antagonism found in rodent studies could also be observed in nonhuman primates. In addition, we studied whether the lack of EPS observed in rodents also applies to primates......Xanomeline is a muscarinic M(1)/M(4) preferring receptor agonist with little or no affinity for dopamine receptors. The compound reduces psychotic-like symptoms in patients with Alzheimer's disease and exhibits an antipsychotic-like profile in rodents without inducing extrapyramidal side effects...

  5. Influence of microstructure in corrosion behavior of an Inconel 600 commercial alloy in 0.1 M sodium thiosulfate solution

    Granados, J.; Rodriguez, F.J.; Arganis, C.

    1999-01-01

    The Inconel 600 is used in diverse components of BWR and PWR type reactors, where diverse cases of intergranular stress corrosion have been presented. It has been reported susceptibility to the corrosion of this alloy, in presence of thiosulfates, which come from the degradation of the ion exchange resins of water treatments that use the reactors. The objective of this work is to study the influence of metallurgical condition in the corrosion velocity of Inconel 600 commercial alloy, in a 0.1 M thiosulfates solution. (Author)

  6. Justify of implementation of a hot water layer system in swimming pool research reactor IEA-R1m

    Toyoda, Eduardo Yoshio; Gordon, Ana Maria Pinho Leite; Sordi, Gian-Maria A.A.

    2001-01-01

    The IPEN/CNEN-SP has a swimming pool research reactor (IEA-R1m) in operation since 1957 at 2 MW. In 1998, after some modifications, its nominal power increased to 5 MW. Among these modifications some adaptations had to be accomplished in the radiological protection and operational procedure. The present work aim to study the need of implementation of a hot water layer in order to reduce the dose in the workers in the vicinity of the reactor swimming pool. Applying the principles of radioprotection optimization, it was concluded that the decision of the construction of one hot water layer system in the reactor swimming pool, is not necessary. (author)

  7. The structure of the Myo4p globular tail and its function in ASH1 mRNA localization.

    Heuck, Alexander; Fetka, Ingrid; Brewer, Daniel N; Hüls, Daniela; Munson, Mary; Jansen, Ralf-Peter; Niessing, Dierk

    2010-05-03

    Type V myosin (MyoV)-dependent transport of cargo is an essential process in eukaryotes. Studies on yeast and vertebrate MyoV showed that their globular tails mediate binding to the cargo complexes. In Saccharomyces cerevisiae, the MyoV motor Myo4p interacts with She3p to localize asymmetric synthesis of HO 1 (ASH1) mRNA into the bud of dividing cells. A recent study showed that localization of GFP-MS2-tethered ASH1 particles does not require the Myo4p globular tail, challenging the supposed role of this domain. We assessed ASH1 mRNA and Myo4p distribution more directly and found that their localization is impaired in cells expressing globular tail-lacking Myo4p. In vitro studies further show that the globular tail together with a more N-terminal linker region is required for efficient She3p binding. We also determined the x-ray structure of the Myo4p globular tail and identify a conserved surface patch important for She3p binding. The structure shows pronounced similarities to membrane-tethering complexes and indicates that Myo4p may not undergo auto-inhibition of its motor domain.

  8. Chronic Stress Reduces Nectin-1 mRNA Levels and Disrupts Dendritic Spine Plasticity in the Adult Mouse Perirhinal Cortex

    Qian Gong

    2018-03-01

    Full Text Available In adulthood, chronic exposure to stressful experiences disrupts synaptic plasticity and cognitive function. Previous studies have shown that perirhinal cortex-dependent object recognition memory is impaired by chronic stress. However, the stress effects on molecular expression and structural plasticity in the perirhinal cortex remain unclear. In this study, we applied the chronic social defeat stress (CSDS paradigm and measured the mRNA levels of nectin-1, nectin-3 and neurexin-1, three synaptic cell adhesion molecules (CAMs implicated in the adverse stress effects, in the perirhinal cortex of wild-type (WT and conditional forebrain corticotropin-releasing hormone receptor 1 conditional knockout (CRHR1-CKO mice. Chronic stress reduced perirhinal nectin-1 mRNA levels in WT but not CRHR1-CKO mice. In conditional forebrain corticotropin-releasing hormone conditional overexpression (CRH-COE mice, perirhinal nectin-1 mRNA levels were also reduced, indicating that chronic stress modulates nectin-1 expression through the CRH-CRHR1 system. Moreover, chronic stress altered dendritic spine morphology in the main apical dendrites and reduced spine density in the oblique apical dendrites of perirhinal layer V pyramidal neurons. Our data suggest that chronic stress disrupts cell adhesion and dendritic spine plasticity in perirhinal neurons, which may contribute to stress-induced impairments of perirhinal cortex-dependent memory.

  9. Study of gamma-ray induced variability on F1M1-F3M3 distant tomato hybrids

    Siromeatnicov, Iulia; Cotenco, Eugenia; Ciobanu, Renata

    2013-01-01

    The outcome of the evaluation of the gamma radiation's action, the growth and development tomato plant has shown that the coefficient of variation of plant height character is on the rise with increasing doses of gamma radiation. The hybrid combination F 1 M 1 (L.hpriz.1998) irradiated with dose 150 Gy variant presented superior value a towards scrutiny for plant height of the characters, number of flowers and fruits per bunch, number of fruits per plant and fruit mass of. The character F 2 M 2 generation plant height registered diminished value compared to F 1 M 1 generation. The highest value was recorded at the hybrid combination F 2 M 2 L.hpriz.1998 200 Gy treated dose. The evaluation research has highlighted that at the doses 100 Gy, 150 Gy, 200 Gy, have confirmed an increase in characters of reproductive system: the number of flowers and fruits per bunch, number of fruits per plant, fruit mass and reduction of the characters waist and height of placing of the first inflorescences plant. Similar aspects with some differences as low as hybrid combination Lhpi1998 in relation to the radiation doses used under study were confirmed in the case F 3 M 3 . (authors)

  10. Synergistic Effect of L-Methionine and KI on Copper Corrosion Inhibition in HNO3 (1M

    Amel SEDIK

    2014-05-01

    Full Text Available L-Methionine (L-Met efficiency as a non-toxic corrosion inhibitor for copper in 1M HNO3 has been studied by using electrochemical impedance spectroscopy (EIS and potentiodynamic polarization. Copper corrosion rate significant decrease was observed in the presence of L-Met at 10-4M. The Obtained Results from potentiodynamic polarization and impedance measurements are in good agreement. L-Methionine adsorption on copper surface follows Langmuir isotherm. L-Met free energy adsorption on copper (-30 KJ mol-1 reveals an inhibition strong physical adsorption on copper surface. In order to evaluate the L-Met effect, L-Met and iodide ion’synergistic effect was used to prevent copper corrosion in nitric acid. It was found that inhibitor efficiency (IE reached 98.27 % in 1M solution containing 10-4M L-Met and 10- 3 M KI. The synergistic effect was attributed to iodide ions adsorption on copper surface, which facilitated the L-Met adsorption and an inhibitive film formation.

  11. Synthesis and characterization of a novel organic corrosion inhibitor for mild steel in 1 M hydrochloric acid

    Ahmed, Mohammed H. Othman; Al-Amiery, Ahmed A.; Al-Majedy, Yasmin K.; Kadhum, Abdul Amir H.; Mohamad, Abu Bakar; Gaaz, Tayser Sumer

    2018-03-01

    The synthesis and characterization of a novel organic corrosion inhibitor (4-(3-mercapto-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazin-6-yl)phenol), for mild steel in 1 M hydrochloric acid (HCl) has been successfully reported for the first time. The inhibitor evaluated as corrosion inhibitor for mild steel in 1 M of Hydrochloric acid solution using electrochemical impedance spectroscopy (EIS), and electrochemical frequency modulation (EFM) measurement techniques. Changes in the impedance parameters suggested an adsorption of the inhibitor onto the mild steel surface, leading to the formation of protective films. The results show that the inhibition efficiencies increased with increasing the concentrations of the inhibitors and decreased with increasing temperature. The maximum inhibition efficiency up to 67% at the maximum concentration 0.5 mM. This shows that those inhibitors are effective in helping to reduce and slowing down the corrosion process that occurs to mild steel with a hydrochloric acid solution by providing an organic inhibitor for the mild steel that can be weakened by increasing the temperature. The adsorption process of the synthesized organic inhibitor depends on its electronic characteristics in addition to steric effects and the nature of metal surface, temperature degree and the varying degrees of surface-site activity. The synthesized inhibitor molecules were absorbed by metal surface and follow Langmuir isotherms.

  12. Preliminary validation of computational model for neutron flux prediction of Thai Research Reactor (TRR-1/M1)

    Sabaibang, S.; Lekchaum, S.; Tipayakul, C.

    2015-05-01

    This study is a part of an on-going work to develop a computational model of Thai Research Reactor (TRR-1/M1) which is capable of accurately predicting the neutron flux level and spectrum. The computational model was created by MCNPX program and the CT (Central Thimble) in-core irradiation facility was selected as the location for validation. The comparison was performed with the typical flux measurement method routinely practiced at TRR-1/M1, that is, the foil activation technique. In this technique, gold foil is irradiated for a certain period of time and the activity of the irradiated target is measured to derive the thermal neutron flux. Additionally, the flux measurement with SPND (self-powered neutron detector) was also performed for comparison. The thermal neutron flux from the MCNPX simulation was found to be 1.79×1013 neutron/cm2s while that from the foil activation measurement was 4.68×1013 neutron/cm2s. On the other hand, the thermal neutron flux from the measurement using SPND was 2.47×1013 neutron/cm2s. An assessment of the differences among the three methods was done. The difference of the MCNPX with the foil activation technique was found to be 67.8% and the difference of the MCNPX with the SPND was found to be 27.8%.

  13. Aberrant Expression of TNF-α and TGF-β1 mRNA in Spontaneous Abortion

    Ji-fen HU; Hong-chu BAO; Feng-chuan ZHU; Cai-ling YOU

    2004-01-01

    Objective To investigate the aberrant expressions of TNF-α and TGF-β1 in peripheral blood mononuclear cells (PBMCs) and placental tissues in patients with early spontaneous abortionMethods Using the technique of semi-quantitative reverse transcript-polymerase chain reaction (RT-PCR), TNF-α mRNA and TGF-β1 mRNA in PBMCs were measured in spontaneous abortion group (30 cases), normal pregnancy group (25 cases) and nonpregnant group (25 cases). The expressive intension of TNF-α protein and TGF-β1 protein in placental tissues was also identified by immunohistochemistry.Results Both levels of TNF-α mRNA and TGF-β1 mRNA expressed in PBMCs were significantly different between the three groups respectively (P<0. 05). Levels of TNF-α in syncytiotrophoblastic and cytotrophoblastic cells of the two aborted groups were substantially higher than those of the non-pregnant group (P<0. 01), but the levels of TGF-β1 in syncytiotrophoblastic cells of the two aborted groups were markedly lower than those of the non-pregnant group (P<0. 01).Conclusion There is potential relation between TGF-β1 at the fetomaternal interface and spontaneous abortion. TGF-β1 may contribute to the maintenance of pregnancy,and low-level expression of TGF-β1 may be associated with pregnancy failure.

  14. Compact 1 mJ fiber MOPA for space-based laser-ablation resonant ionization mass spectrometry (LARIMS)

    Mu, Xiaodong; Crain, William; Nguyen, Can; Ionov, Pavel; Steinvurzel, Paul; Dotan, Yaniv; Karuza, Petras; Lotshaw, William; Rose, Todd; Beck, Steven; Anderson, F. Scott

    2018-02-01

    A 1064 nm, 1 mJ pulsed fiber MOPA module, housed in 16"x14"x2.5" package for application in a lunar and planetary in-situ surface dating instrument is demonstrated. The module is based on a three-stage MOPA with a 60 μm core tapered fiber terminal amplifier. The master oscillator and first two preamplifier stages, which generate 20 μJ pulses, are all contained on a 13"x11"x1" board. Several improvements to the electronic signal control were instrumental to the laser development, including bipolar drive of the phase modulator for SBS suppression, shaping of the seed pulse to compensate pulse steepening, and pulsed operation of the power amplifier pump to reduce spontaneous emission at low pulse repetition frequency. The packaged laser runs at a repetition rate of 10 kHz and generates 10 ns pulses at 1 mJ with a 40 GHz linewidth, an M2 1.2 beam quality, and an 18 dB polarization extinction ratio. The modular design enables seven independent lasers to be stacked in a 20"x18"x16.25" enclosure, supporting a path towards a fiber laser based LARIMS for advanced materials characterization and chronological dating in harsh and remote environments.

  15. Optimal Physical and Nutrient Parameters for Growth of Trichoderma virens UKMP-1M for Heavy Crude Oil Degradation

    Ainon Hamzah; Buzarin, M.A.; Aidil Abdul Hamid; Thmanomar, O.; Sahidan Senafi

    2012-01-01

    This study was carried out to determine the optimal parameters for the production of biomass of Trichoderma virens UKMP-1M, a fungus isolated from oil-polluted wastewater. The isolate showed maximum growth at day six after incubation in Mineral Salt Medium (MSM) in the presence of 3 % (v/ v) heavy Khefji Sour crude oil. Although it grew at pH between 5.0 and 7.0, it grew best at pH 5.5. T. virens UKMP-1M grew at temperatures between 25 and 35 degree Celsius, with its highest growth at 30 degree Celsius. Aeration by agitation at 200 rpm was shown to yield the greatest biomass. Peptone at concentration of 1.5 % (w/ v) was determined to be a better nitrogen source than urea, potassium nitrate (KNO 3 ), yeast extract, ammonium sulphate ((NH 4 ) 2 SO 4 ) and ammonium chloride (NH 4 Cl). Addition of 1 % (v/ v) crude oil to the MSM medium led to higher biomass production than the addition of 3 %, 5 %, 7 % and 10 % (v/ v) crude oil. The result also revealed that 40 % of total petroleum hydrocarbon (TPH), 100 % of pristane and 74 % of phytane compounds were degraded after 9 days of incubation at optimal physical and nutrient parameters. (author)

  16. Diseño del manual de certificación de las estaciones reparadoras para la estandarización de procedimientos de mantenimiento de productos aeronáuticos de la Fuerza Aérea Colombiana

    Ricardo Garzón Monroy

    2006-01-01

    Full Text Available El propósito de esta investigación es señalar la normatividad y procedimientos que se necesitan para elaborar el Manual de Certificación de las Estaciones Reparadoras  para la Estandarización de Procedimientos en el Mantenimiento de Productos Aeronáuticos de la Fuerza Aérea Colombiana, cuyo propósito es certificar los procesos de las estaciones reparadoras y suministrar al personal de la Jefatura Técnica y de los Grupos Técnicos en las diferentes unidades las herramientas que servirán para evaluar periódicamente y/o certificar las estaciones reparadoras en Colombia, que prestan sus servicios de mantenimiento para mejorar los niveles de calidad y generar una operación segura de las aeronaves con las que cuenta la Fuerza Aérea. Asimismo, el uso del manual permitirá al personal de mantenimiento de las aeronaves y sus componentes tener un respaldo técnico en la toma de decisiones amparadas en los distintos procesos de certificación.

  17. Militarización de la Policía y Policización de las Fuerzas Militares. Revisión del fenómeno a nivel internacional y nacional

    William Guillermo Jímenez

    2011-07-01

    Full Text Available El documento tiene por objeto ofrecer un panorama acerca del doble fenómeno de la militarización de la policía y de la policización de las fuerzas militares en algunos países. Para ello se hace una revisión documental sobre la temática analizando los casos de Alemania, Estados Unidos, México, Brasil, Chile y Colombia. La información analizada permite concluir que la división misional clásica entre Policía y Fuerzas Militares no se está dando en la práctica, debido a factores internos de manejo de orden público, a la organización militar de la Policía desde sus orígenes y a cambios en la concepción acerca de la seguridad y la soberanía de los Estados.

  18. ¿Inserción laboral de las mujeres en América Latina: una fuerza de trabajo secundaria? Women's participation in the labor market in Latin America: a secondary work force?

    Laís Abramo

    2004-08-01

    Full Text Available El objetivo principal de este texto es discutir la aplicación de la noción de "fuerza de trabajo secundaria" para caracterizar la fuerza da trabajo femenina en América Latina. Esa caracterización, hecha con frecuencia en forma mecánica por un lado corresponde, cada vez menos a la realidad de los hechos, ya que es creciente la participación femenina en el mercado de trabajo, así como la continuidad de sus trayectorias laborales, el número de horas dedicadas al trabajo remunerado, así como su aporte al ingreso familiar y a la superación de la situación de pobreza de un porcentaje importante de hogares. Por otro lado, el texto argumenta que esa caracterización es uno de los elementos centrales en la estructuración de los patrones de discriminación de género que persisten y se reproducen en el mercado de trabajo latinoamericano.This article aims to discuss the concept of "secondary labor force" to characterize female workforce in Latin America. Such characterization corresponds increasingly less to reality, as women's participation in the labor force and the hours dedicated to their paid work continues to grow, as well as their contribution to household income. The article argues that such characterization is one of the core elements of the gender discriminating patterns that persist in Latin American labor market.

  19. Efecto de la hipnosis y la terapia de aceptación y compromiso (ACT en la mejora de la fuerza física en piragüistas

    Rubén Fernández García

    2004-01-01

    Full Text Available En este experimento simple se evaluó la eficacia diferencial de dos técnicas de intervención psicológica -hipnosis y terapia de aceptación y compromiso (ACT- para la mejora de la fuerza física. Participaron en la investigación 16 deportistas de élite, practicantes de piragüismo. A todos los sujetos se les evaluó el grado de sugestibilidad. A los deportistas tratados con hipnosis se les aplicó una breve técnica de relajación, una fase de inducción, introducción de sugestión post-hipnótica y fase de salida del estado hipnótico. La intervención con ACT se dirigió principalmente a la aceptación de determinados eventos privados y estados corporales, enfocando sus conductas de ejecución en dirección a sus valores. Los resultados mostraron mejoras significativas en ambos grupos de intervención en el número de repeticiones en el ejercicio de remo inclinado. Se hace necesario el desarrollo de posteriores investigaciones para verificar la utilidad de estas técnicas en la mejora de la fuerza física y, por tanto, del rendimiento deportivo.

  20. Relación del peso máximo con la fuerza aplicada y la potencia producida en un test creciente, en el ejercicio de press de banca plano con barra libre, en levantadores

    Fernando Naclerio Ayllón

    2006-12-01

    Full Text Available Se evaluaron 9 levantadores que realizaron 2 test, en el ejercicio de press de banca plano con barra libre. Un test progresivo con pesos ligeros a máximos (TPR, y el test de una máxima repetición (1 MRD. Se midió la fuerza (f, velocidad (v y potencia (p con cada peso movilizado, se determinó el máximo peso desplazado en una única repetición (1 MR. Se observaron correlaciones significativas entre el valor de la 1 MR obtenida en el test de 1 MRPr y el de 1 MRD, entre la potencia máxima (absoluta y relativa al peso corporal y la 1 MR absoluta y relativa al peso corporal. No se observaron diferencias significativas (p < 0,05 entre el valor de la 1 MR obtenida en el test progresivo (1 MRPr y el alcanzado en el test de 1 MRD. Se acepta la aplicación del test progresivo (TPR para determinar los niveles de f, v, p, el valor de la 1 MR en kg, así como localizar los porcentajes de peso, respecto al nivel de la 1 MR, en donde se alcanzan los valores más altos de potencia mecánica, y estimar las adaptaciones funcionales inducidas por los entrenamientos de fuerza.

  1. Influenza A Virus NS1 Protein Promotes Efficient Nuclear Export of Unspliced Viral M1 mRNA.

    Pereira, Carina F; Read, Eliot K C; Wise, Helen M; Amorim, Maria J; Digard, Paul

    2017-08-01

    Influenza A virus mRNAs are transcribed by the viral RNA-dependent RNA polymerase in the cell nucleus before being exported to the cytoplasm for translation. Segment 7 produces two major transcripts: an unspliced mRNA that encodes the M1 matrix protein and a spliced transcript that encodes the M2 ion channel. Export of both mRNAs is dependent on the cellular NXF1/TAP pathway, but it is unclear how they are recruited to the export machinery or how the intron-containing but unspliced M1 mRNA bypasses the normal quality-control checkpoints. Using fluorescent in situ hybridization to monitor segment 7 mRNA localization, we found that cytoplasmic accumulation of unspliced M1 mRNA was inefficient in the absence of NS1, both in the context of segment 7 RNPs reconstituted by plasmid transfection and in mutant virus-infected cells. This effect was independent of any major effect on steady-state levels of segment 7 mRNA or splicing but corresponded to a ∼5-fold reduction in the accumulation of M1. A similar defect in intronless hemagglutinin (HA) mRNA nuclear export was seen with an NS1 mutant virus. Efficient export of M1 mRNA required both an intact NS1 RNA-binding domain and effector domain. Furthermore, while wild-type NS1 interacted with cellular NXF1 and also increased the interaction of segment 7 mRNA with NXF1, mutant NS1 polypeptides unable to promote mRNA export did neither. Thus, we propose that NS1 facilitates late viral gene expression by acting as an adaptor between viral mRNAs and the cellular nuclear export machinery to promote their nuclear export. IMPORTANCE Influenza A virus is a major pathogen of a wide variety of mammalian and avian species that threatens public health and food security. A fuller understanding of the virus life cycle is important to aid control strategies. The virus has a small genome that encodes relatively few proteins that are often multifunctional. Here, we characterize a new function for the NS1 protein, showing that, as well as

  2. Hydrogen evolution reaction at Ru-modified nickel-coated carbon fibre in 0.1 M NaOH

    Pierożyński Bogusław

    2015-03-01

    Full Text Available The electrochemical activity towards hydrogen evolution reaction (HER was studied on commercially available (Toho-Tenax and Ru-modified nickel-coated carbon fibre (NiCCF materials. Quality and extent of Ru electrodeposition on NiCCF tows were examined by means of scanning electron microscopy (SEM. Kinetics of the hydrogen evolution reaction were investigated at room temperature, as well as over the temperature range: 20-50°C in 0.1 M NaOH solution for the cathodic overpotential range: -100 to -300 mV vs. RHE. Corresponding values of charge-transfer resistance, exchange current-density for the HER and other electrochemical parameters for the examined fibre tow composites were recorded.

  3. Development of an emergency core cooling system for the converted IEA-R1m research reactor

    Torres, Walmir Maximo; Baptista Filho, Benedito Dias; Ting, Daniel Kao Sun [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil). Dept. de Tecnologia de Reatores]. E-mail: wmtorres@net.ipen.br; bdbfilho@net.ipen.br; dksting@net.ipen.br

    1998-07-01

    This present work describes the development program carried out in the design and construction of the Emergency Core Cooling System for the IEA-R1m Research Reactor, including the system design, the experiments performed to validate the design, manufacturing, installation and commissioning. The experiments were performed in two phases. In the first phase, the spray flow rate and distribution were measured, using a full scale mock-up of the entire core, to establish the spray header geometry and specifications. In the second phase, a test section was fitted with electrically heated plates to simulate the fuel plates. Temperature measurements were carried out to demonstrate the effectiveness of the system to keep the temperatures below the limiting value. The experimental results were shown to the licensing authorities during the certification process. The main difficulties during the system assembly are also described. (author)

  4. Status of prompt gamma neutron activation analysis (PGAA) at TRR-1/M1 (Thai Research Reactor-1/Modified 1)

    Asvavijnijkulchai, Chanchai; Dharmavanij, Wanchai; Siangsanan, Pariwat; Ratanathongchai, Wichian; Chongkum, Somporn

    1999-01-01

    The first prompt gamma activation analysis (PGAA) was designed, constructed and installed at a 6 inch diameter neutron beam port of the Thai Research Reactor-1/Modified 1 (TRR-1/M1) since 1989. Beam characteristic were made by Gd foil irradiation, X-ray film exposing and densitometry scanning consequently. The thermal neutron flux at sample position was measured by Au foil activation, and was about 1 x 10 7 n.cm 2 .sec -1 at 700 kW operating power. The experiments have been conducted successfully. In 1998, the PGAA facility has been developed for the reactor operating power at 1.2 MW. The new PGAA system, e.g., beam shutter, gamma collimator and biological shields have been designed to reduce the leakage of neutrons and gamma radiation to the acceptance levels in accordance with the International Commission on Radiation Protection Publication 60 (ICRP 60). The construction and installation will be completed in April 1999. (author)

  5. Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing

    Lee, Seungmin; Rose, Simon; Metodiev, Metodi D

    2015-01-01

    maternally inherited traits. The pathophysiology induced by mtDNA mutations has traditionally been attributed to deficient oxidative phosphorylation, which causes energy crisis with functional impairment of multiple cellular processes. In contrast, it was recently reported that signaling induced......Mitochondrial dysfunction is a well-established cause of sensorineural deafness, but the pathophysiological events are poorly understood. Non-syndromic deafness and predisposition to aminoglycoside-induced deafness can be caused by specific mutations in the 12S rRNA gene of mtDNA and are thus...... by 'hypermethylation' of two conserved adenosines of 12S rRNA in the mitoribosome is of key pathophysiological importance in sensorineural deafness. In support for this concept, it was reported that overexpression of the essential mitochondrial methyltransferase TFB1M in the mouse was sufficient to induce...

  6. Role of advanced refuelling and heating on edge Reynolds stress-induced poloidal flow in HL-1M

    Hong Wenyu; Wang Enyao; Li Qiang; Cao Jianyong; Yan Longwen

    2002-01-01

    The radial profile of electrostatic Reynolds stress, plasma poloidal rotations, radial and poloidal electric fields have been measured in the plasma boundary region of the HL-1M tokamak using a multi-array of Mach/Langmuir probes. In the experiments of ohmic discharge, lower hybrid current drive, supersonic molecular beam injection (SMBI) and multi-shot pellet injection, the correlation between the Reynolds stress and poloidal flow in the edge plasma is presented. The radial profile changes of the Reynolds stress and poloidal flow velocity V pol with lower hybrid wave injection power and SMBI injection are obtained. The results indicate that the sheared poloidal flow can be generated in tokamak plasma due to the radially varying Reynolds stress

  7. The Norwegian Earth System Model, NorESM1-M – Part 2: Climate response and scenario projections

    T. Iversen

    2013-03-01

    Full Text Available NorESM is a generic name of the Norwegian earth system model. The first version is named NorESM1, and has been applied with medium spatial resolution to provide results for CMIP5 (http://cmip-pcmdi.llnl.gov/cmip5/index.html without (NorESM1-M and with (NorESM1-ME interactive carbon-cycling. Together with the accompanying paper by Bentsen et al. (2012, this paper documents that the core version NorESM1-M is a valuable global climate model for research and for providing complementary results to the evaluation of possible anthropogenic climate change. NorESM1-M is based on the model CCSM4 operated at NCAR, but the ocean model is replaced by a modified version of MICOM and the atmospheric model is extended with online calculations of aerosols, their direct effect and their indirect effect on warm clouds. Model validation is presented in the companion paper (Bentsen et al., 2012. NorESM1-M is estimated to have equilibrium climate sensitivity of ca. 2.9 K and a transient climate response of ca. 1.4 K. This sensitivity is in the lower range amongst the models contributing to CMIP5. Cloud feedbacks dampen the response, and a strong AMOC reduces the heat fraction available for increasing near-surface temperatures, for evaporation and for melting ice. The future projections based on RCP scenarios yield a global surface air temperature increase of almost one standard deviation lower than a 15-model average. Summer sea-ice is projected to decrease considerably by 2100 and disappear completely for RCP8.5. The AMOC is projected to decrease by 12%, 15–17%, and 32% for the RCP2.6, 4.5, 6.0, and 8.5, respectively. Precipitation is projected to increase in the tropics, decrease in the subtropics and in southern parts of the northern extra-tropics during summer, and otherwise increase in most of the extra-tropics. Changes in the atmospheric water cycle indicate that precipitation events over continents will become more intense and dry spells more frequent. Extra

  8. Alginate biopolymer as green corrosion inhibitor for copper in 1 M hydrochloric acid: Experimental and theoretical approaches

    Jmiai, A.; El Ibrahimi, B.; Tara, A.; El Issami, S.; Jbara, O.; Bazzi, L.

    2018-04-01

    The anti-corrosion behavior of sodium alginate (SA) on copper in the 1 M hydrochloric medium was carried out using weight loss and electrochemical measurements. The obtained results show that the inhibition increases with SA concentration and then reaches a maximum of 83% at a concentration of 0.1 mg L-1. The effect of temperature on the reactions of copper corrosion inhibition and analyzing the thermodynamic parameters revealed that the mode of adsorption has a physical nature and obeys the Langmuir isotherm. The surface morphology was performed by scanning electron microscopy coupled with energy dispersive X-ray spectrometry and atomic force microscopy. To better understand the adsorption mechanism, describing the relationship between inhibitory ability and the molecular structure of SA, quantum calculations using density functional theory were performed. Monte Carlo simulation approache was performed to know well of the relationship between the inhibition ability and molecular structure of alginate.

  9. Ultra-long pulse operation using lower hybrid waves on the superconducting high field tokamak TRIAM-1M

    Moriyama, S.; Nakamura, Y.; Nagao, A.; Jotaki, E.; Nakamura, K.; Hiraki, N.; Itoh, S.

    1990-01-01

    Ultra-long pulse operation (>3 min) was achieved on the superconducting high field tokamak TRIAM-1M. In this operation, the plasma current was maintained with a relatively peaked current distribution by the 2.45 GHz radiofrequency power (P RF ≤ 35 kW) alone. A stationary plasma with a driven current of up to 35 kA and a line averaged electron density of up to 3x10 12 cm -3 was produced by precise plasma position and gas feed control. The extremely long discharge showed the interesting characteristics that the high temperatures of about 1 keV for the electrons and about 0.5 keV for the ions were kept almost constant during steady state current drive and that there was no impurity accumulation which could have a fatally adverse effect on steady state tokamak operation. (author). 16 refs, 17 figs

  10. Difference in oxygen impurity behavior between repetitive short discharges and one long discharge on TRIAM-1M

    Ogawa, M.; Sakamoto, M.; Sato, K.N.; Zushi, H.; Nakamura, K.; Hanada, K.; Idei, H.; Hasegawa, M.; Kawasaki, S.; Nakashima, H.; Higashijima, A.

    2007-01-01

    Oxygen impurity behaviors of one long duration discharge and repetition of short duration discharges have been investigated in TRIAM-1M. In the former case, the OII line intensity divided by the line averaged electron density, which is considered as a monitor of oxygen concentration on the plasma facing surface (PFS), decreased with the time constant, τ d , of 30-50 s during the discharge due to the hydrogen flux to PFS. In the latter case, τ d is in the range of 70-600 s. There exists a big difference of global behavior of oxygen impurity between both cases. The difference seems to result from the absence or presence of the interval time between the discharges. The oxygen concentration on PFS increases during the interval time due to adsorption of H 2 O. The time constant of the increase in the oxygen concentration is evaluated to be about 5500 s from Langmuir adsorption isotherms analysis

  11. On one-loop corrections to matching conditions of lattice HQET including 1/m{sub b} terms

    Korcyl, Piotr [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC

    2013-12-15

    HQET is an effective theory for QCD with N{sub f} light quarks and a massive valence quark if the mass of the latter is much bigger than LQCD. As any effective theory, HQET is predictive only when a set of parameters has been determined through a process called matching. The non-perturbative matching procedure including 1/m{sub b} terms, developed by the ALPHA collaboration, consists of 19 carefully chosen observables which are precisely computable in lattice QCD as well as in lattice HQET. The matching conditions are then a set of 19 equations which relate the QCD and HQET values of these observables. We present a study of one-loop corrections to two generic matching observables involving correlation function with an insertion of the A{sub 0} operator. Our results enable us to quantify the quality of the relevant observables in view of the envisaged nonperturbative implementation of this matching procedure.

  12. Fluoroethylene Carbonate-Based Electrolyte with 1 M Sodium Bis(fluorosulfonyl)imide Enables High-Performance Sodium Metal Electrodes.

    Lee, Yongwon; Lee, Jaegi; Lee, Jeongmin; Kim, Koeun; Cha, Aming; Kang, Sujin; Wi, Taeung; Kang, Seok Ju; Lee, Hyun-Wook; Choi, Nam-Soon

    2018-05-02

    Sodium (Na) metal anodes with stable electrochemical cycling have attracted widespread attention because of their highest specific capacity and lowest potential among anode materials for Na batteries. The main challenges associated with Na metal anodes are dendritic formation and the low density of deposited Na during electrochemical plating. Here, we demonstrate a fluoroethylene carbonate (FEC)-based electrolyte with 1 M sodium bis(fluorosulfonyl)imide (NaFSI) salt for the stable and dense deposition of the Na metal during electrochemical cycling. The novel electrolyte combination developed here circumvents the dendritic Na deposition that is one of the primary concerns for battery safety and constructs the uniform ionic interlayer achieving highly reversible Na plating/stripping reactions. The FEC-NaFSI constructs the mechanically strong and ion-permeable interlayer containing NaF and ionic compounds such as Na 2 CO 3 and sodium alkylcarbonates.

  13. Development of the optical system for the SST-1M telescope of the Cherenkov Telescope Array observatory

    Ostrowski, Michael; Błocki, J.; Bogacz, L.; Bulik, T.; Cadoux, F.; Christov, A.; Curyło, M.; della Volpe, D.; Dyrda, M.; Favre, Y.; Frankowski, A.; Grudnik, Ł.; Grudzińska, M.; Heller, M.; Idźkowski, B.; Jamrozy, M.; Janiak, M.; Kasperek, J.; Lalik, K.; Lyard, E.; Mach, E.; Mandat, D.; Marszałek, A.; Michałowski, J.; Moderski, R.; Montaruli, T.; Neronov, A.; Niemiec, J.; Paśko, P.; Pech, M.; Porcelli, A.; Prandini, E.; Pueschel, E.; Rajda, P.; Rameez, M.; Schioppa, E. jr; Schovanek, P.; Skowron, K.; Sliusar, V.; Sowiński, M.; Stawarz, Ł.; Stodulska, M.; Stodulski, M.; Toscano, S.; Troyano Pujadas, I.; Walter, R.; Wiȩcek, M.; Zagdański, A.; Ziȩtara, K.; Żychowski, P.; Barciński, T.; Karczewski, M.; Kukliński, J. Nicolau; Płatos, Ł.; Rataj, M.; Wawer, P.; Wawrzaszek, R.

    2016-01-01

    The prototype of a Davies-Cotton small size telescope (SST-1M) has been designed and developed by a consortium of Polish and Swiss institutions and proposed for the Cherenkov Telescope Array (CTA) observatory. The main purpose of the optical system is to focus the Cherenkov light emitted by extensive air showers in the atmosphere onto the focal plane detectors. The main component of the system is a dish consisting of 18 hexagonal mirrors with a total effective collection area of 6.47 m2 (including the shadowing and estimated mirror reflectivity). Such a solution was chosen taking into account the analysis of the Cherenkov light propagation and based on optical simulations. The proper curvature and stability of the dish is ensured by the mirror alignment system and the isostatic interface to the telescope structure. Here we present the design of the optical subsystem together with the performance measurements of its components.

  14. Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing.

    Alixe H M Kilgour

    Full Text Available Sarcopenia, the loss of muscle mass and function with age, is associated with increased morbidity and mortality. Current understanding of the underlying mechanisms is limited. Glucocorticoids (GC in excess cause muscle weakness and atrophy. We hypothesized that GC may contribute to sarcopenia through elevated circulating levels or increased glucocorticoid receptor (GR signaling by increased expression of either GR or the GC-amplifying enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11βHSD1 in muscle.There were 82 participants; group 1 comprised 33 older men (mean age 70.2 years, SD 4.4 and 19 younger men (22.2 years, 1.7 and group 2 comprised 16 older men (79.1 years, 3.4 and 14 older women (80.1 years, 3.7. We measured muscle strength, mid-thigh cross-sectional area, fasting morning plasma cortisol, quadriceps muscle GR and 11βHSD1 mRNA, and urinary glucocorticoid metabolites. Data were analysed using multiple linear regression adjusting for age, gender and body size.Muscle strength and size were not associated with plasma cortisol, total urinary glucocorticoids or the ratio of urinary 5β-tetrahydrocortisol +5α-tetrahydrocortisol to tetrahydrocortisone (an index of systemic 11βHSD activity. Muscle strength was associated with 11βHSD1 mRNA levels (β -0.35, p = 0.04, but GR mRNA levels were not significantly associated with muscle strength or size.Although circulating levels of GC are not associated with muscle strength or size in either gender, increased cortisol generation within muscle by 11βHSD1 may contribute to loss of muscle strength with age, a key component of sarcopenia. Inhibition of 11βHSD1 may have therapeutic potential in sarcopenia.

  15. Dissociation of SERPINE1 mRNA from the translational repressor proteins Ago2 and TIA-1 upon platelet activation.

    Corduan, Aurélie; Plé, Hélène; Laffont, Benoit; Wallon, Thérèse; Plante, Isabelle; Landry, Patricia; Provost, Patrick

    2015-05-01

    Platelets play an important role in haemostasis, as well as in thrombosis and coagulation processes. They harbour a wide variety of messenger RNAs (mRNAs), that can template de novo protein synthesis, and an abundant array of microRNAs, which are known to mediate mRNA translational repression through proteins of the Argonaute (Ago) family. The relationship between platelet microRNAs and proteins capable of mediating translational repression, however, remains unclear. Here, we report that half of platelet microRNAs is associated to mRNA-regulatory Ago2 protein complexes, in various proportions. Associated to these Ago2 complexes are platelet mRNAs known to support de novo protein synthesis. Reporter gene activity assays confirmed the capacity of the platelet microRNAs, found to be associated to Ago2 complexes, to regulate translation of these platelet mRNAs through their 3'UTR. Neither the microRNA repertoire nor the microRNA composition of Ago2 complexes of human platelets changed upon activation with thrombin. However, under conditions favoring de novo synthesis of Plasminogen Activator Inhibitor-1 (PAI-1) protein, we documented a rapid dissociation of the encoding platelet SERPINE1 mRNA from Ago2 protein complexes as well as from the translational repressor protein T-cell-restricted intracellular antigen-1 (TIA-1). These findings are consistent with a scenario by which lifting of the repressive effects of Ago2 and TIA-1 protein complexes, involving a rearrangement of proteinmRNA complexes rather than disassembly of Ago2microRNA complexes, would allow translation of SERPINE1 mRNA into PAI-1 in response to platelet activation.

  16. Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice.

    de Azeredo, Lucas Araújo; Wearick-Silva, Luis Eduardo; Viola, Thiago Wendt; Tractenberg, Saulo Gantes; Centeno-Silva, Anderson; Orso, Rodrigo; Schröder, Nadja; Bredy, Timothy William; Grassi-Oliveira, Rodrigo

    2017-05-01

    In rodents, disruption of mother-infant attachment induced by maternal separation (MS) is associated with recognition memory impairment and long-term neurobiological consequences. Particularly stress-induced modifications have been associated to disruption of cadherin (CDH) adhesion function, which plays an important role in remodeling of neuronal connection and synaptic plasticity. This study investigated the sex-dependent effect of MS on recognition memory and mRNA levels of classical type I and type II CDH and the related β -catenin (β -Cat) in the hippocampus and prefrontal cortex of late adolescent mice. We provided evidence that the BALB/c mice exposed to MS present deficit in recognition memory, especially females. Postnatal MS induced higher hippocampal CDH-2 and CDH-8 mRNA levels, as well as an upregulation of CDH-1 in the prefrontal cortex in both males and females. MS-reared female mice presented lower CDH-1 mRNA levels in the hippocampus. In addition, hippocampal CDH-1 mRNA levels were positively correlated with recognition memory performance in females. MS-reared male mice exhibited higher β -Cat mRNA levels in the hippocampus. Considering sex-specific effects on CDH mRNA levels, it has been demonstrated mRNA changes in CDH-1, β -Cat, and CDH-6 in the hippocampus, as well as CDH-1, CDH-8 and CDH-11 in the prefrontal cortex. Overall, these findings suggest a complex interplay among MS, CDH mRNA expression, and sex differences in the PFC and hippocampus of adolescent mice. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Gad1 mRNA as a reliable indicator of altered GABA release from orexigenic neurons in the hypothalamus.

    Dicken, Matthew S; Hughes, Alexander R; Hentges, Shane T

    2015-11-01

    The strength of γ-aminobutyric acid (GABA)-mediated inhibitory synaptic input is a principle determinant of neuronal activity. However, because of differences in the number of GABA afferent inputs and the sites of synapses, it is difficult to directly assay for altered GABA transmission between specific cells. The present study tested the hypothesis that the level of mRNA for the GABA synthetic enzyme glutamate decarboxylase (GAD) can provide a reliable proxy for GABA release. This was tested in a mouse hypothalamic circuit important in the regulation of energy balance. Fluorescent in situ hybridization results show that the expression of Gad1 mRNA (encoding the GAD67 enzyme) was increased in hypothalamic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons after an overnight fast, consistent with the ability of GABA from these neurons to stimulate food intake. Optogenetic studies confirmed that the observed increase in Gad1 mRNA correlated with an increase in the probability of GABA release from NPY/AgRP neurons onto downstream proopiomelanocortin neurons. Likewise, there was an increase in the readily releasable pool of GABA in NPY/AgRP neurons. Selective inhibition of GAD activity in NPY/AgRP neurons decreased GABA release, indicating that GAD67 activity, which is largely dictated by expression level, is a key determinant of GABA release. Altogether, it appears that Gad expression may be a reliable proxy of altered GABAergic transmission. Examining changes in Gad mRNA as a proxy for GABA release may be particularly helpful when the downstream targets are not known or when limited tools exist for detecting GABA release at a particular synapse. © 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  18. The crystal structure of human protein α1M reveals a chromophore-binding site and two putative protein–protein interfaces

    Zhang, Yangli; Gao, Zengqiang; Guo, Zhen; Zhang, Hongpeng; Zhang, Zhenzhen; Luo, Miao; Hou, Haifeng; Huang, Ailong; Dong, Yuhui; Wang, Deqiang

    2013-01-01

    Highlights: •We determined the first structure of human α1M with heavy electron density of the chromophore. •We proposed a new structural model of the chromophore. •We first revealed that the two conserved surface regions of α1M are proposed as putative protein–protein interface sites. -- Abstract: Lipocalin α1-microglobulin (α1M) is a conserved glycoprotein present in plasma and in the interstitial fluids of all tissues. α1M is linked to a heterogeneous yellow–brown chromophore of unknown structure, and interacts with several target proteins, including α1-inhibitor-3, fibronectin, prothrombin and albumin. To date, there is little knowledge about the interaction sites between α1M and its partners. Here, we report the crystal structure of the human α1M. Due to the crystallization occurring in a low ionic strength solution, the unidentified chromophore with heavy electron density is observed at a hydrophobic inner tube of α1M. In addition, two conserved surface regions of α1M are proposed as putative protein–protein interface sites. Further study is needed to unravel the detailed information about the interaction between α1M and its partners

  19. Up-regulation of A1M/α1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage.

    Olsson, Magnus G; Allhorn, Maria; Larsson, Jörgen; Cederlund, Martin; Lundqvist, Katarina; Schmidtchen, Artur; Sørensen, Ole E; Mörgelin, Matthias; Akerström, Bo

    2011-01-01

    During bleeding the skin is subjected to oxidative insults from free heme and radicals, generated from extracellular hemoglobin. The lipocalin α(1)-microglobulin (A1M) was recently shown to have reductase properties, reducing heme-proteins and other substrates, and to scavenge heme and radicals. We investigated the expression and localization of A1M in skin and the possible role of A1M in the protection of skin tissue from damage induced by heme and reactive oxygen species. Skin explants, keratinocyte cultures and purified collagen I were exposed to heme, reactive oxygen species, and/or A1M and investigated by biochemical methods and electron microscopy. The results demonstrate that A1M is localized ubiquitously in the dermal and epidermal layers, and that the A1M-gene is expressed in keratinocytes and up-regulated after exposure to heme and reactive oxygen species. A1M inhibited the heme- and reactive oxygen species-induced ultrastructural damage, up-regulation of antioxidation and cell cycle regulatory genes, and protein carbonyl formation in skin and keratinocytes. Finally, A1M bound to purified collagen I (K(d) = 0.96×10(-6) M) and could inhibit and repair the destruction of collagen fibrils by heme and reactive oxygen species. The results suggest that A1M may have a physiological role in protection of skin cells and matrix against oxidative damage following bleeding.

  20. La fuerza ilocutiva en los debates medievales castellanos de controversia y su plasmación lingüística

    Elena LEAL ABAD

    2008-10-01

    Full Text Available La presencia de actos de habla indirectos en algunas tipologías de diálogos literarios medievales, especialmente en los que presentan un carácter didáctico-moralizante, no siempre obedece a la noción de cortesía. El espíritu de controversia de estos textos origina que la falta de coincidencia entre modalidad del enunciado y modalidad de la enunciación se relacione con un deseo de distanciamiento dialéctico entre los personajes de la interacción, que tratan de socavar la imagen del interlocutor a través de enunciados que pretenden deslegitimar, ridiculizar o descalificar al adversario. Estos valores descorteses de los enunciados interrogativos derivan fundamentalmente del propio contenido proposicional aunque también constituyen indicios importantes la asimetría de los personajes que intervienen y las propias características del género discursivo. No obstante, en este mismo contexto aparecen mecanismos que tratan de contrarrestar la fuerza ilocutiva de estos actos descorteses minimizando el desacuerdo. En las páginas que siguen se tratará de determinar qué formas y estrategias lingüísticas se adoptan para acometer este tipo de actos y su relación con estructuras propias de la interacción comunicativa con el objetivo de captar una posible evolución de recursos o constancia de los mismos a lo largo de la historia del español.La présence d'actes de langage indirects dans certaines typologies de dialogues littéraires médiévaux, en particulier dans ceux qui présentent un caractère didactico-moralisant, n'obéit pas toujours à la notion de courtoisie. L'esprit de polémique de ces textes engendre la mise en relation du manque de coïncidence entre modalité de l'énoncé et modalité de l'énonciation et d’un désir d'éloignement dialectique entre les personnages de l'interaction, qui essayent de miner l'image de l'interlocuteur au travers d’énoncés qui prétendent délégitimer, ridiculiser ou discréditer l

  1. Respuesta hemodinámica con el entrenamiento en resistencia y fuerza muscular de miembros superiores en rehabilitación cardiaca Hemodynamic response to training in resistance and muscular strength of upper limbs in cardiac rehabilitation

    Diana M Camargo

    2007-08-01

    Full Text Available Antecedentes: el entrenamiento de la fuerza muscular en pacientes con eventos cardiovasculares, estaba totalmente contraindicado por el riesgo de incrementar las cifras de tensión arterial sistólica y diastólica, así como someter al miocardio a una sobrecarga. Objetivo: valorar la respuesta hemodinámica (frecuencia cardiaca, tensión arterial durante el entrenamiento de resistencia a la fuerza muscular en los pacientes que asisten a un programa de rehabilitación cardiaca. Diseño: cuasi experimental prospectivo. Excenario: se realizó un entrenamiento de resistencia a la fuerza muscular en miembros superiores a pacientes durante la fase II de rehabilitación cardiaca. Sujetos: se incluyeron 175 pacientes, 135 hombres y 40 mujeres con un promedio de edad de 58,79 años, los cuales presentaron enfermedad coronaria con y sin procedimientos de revascularización, cirugía de cambios valvulares, síncope y corrección quirúrgica de anomalías congénitas. Procedimiento: previo entrenamiento aeróbico (en banda sinfín o bicicleta estática, se realizó la valoración de fuerza muscular mediante una máxima repetición y se inició el entrenamiento de fuerza a 30%-50% de ésta, en circuito de tres ejercicios diferentes en miembros superiores, 10 repeticiones en tres series y frecuencia de dos veces por semana. Se realizó, además, monitoría de la frecuencia cardiaca y electrocardiograma por telemetría (V5, toma de presión arterial antes, durante y después de la sesión, y percepción subjetiva del esfuerzo por escala de Borg, y se observaron signos y síntomas de intolerancia a la actividad o descompensación. Para el análisis estadístico, se utilizaron medidas de tendencia central con los cambios cardiovasculares, y para comparar el cambio en la fuerza muscular, se utilizó una prueba de t pareada con un nivel de significancia de 0,05. Resultados: la fuerza muscular medida con la máxima repetición, evidenció un aumento significativo

  2. ABCG2-overexpressing S1-M1-80 cell xenografts in nude mice keep original biochemistry and cell biological properties.

    Wang, Fang; Liang, Yong-Ju; Wu, Xing-Ping; Su, Xiao-Dong; Fu, Li-Wu

    2012-03-01

    S1-M1-80 cells, derived from human colon carcinoma S1 cells, are mitoxantrone-selected ABCG2-overexpressing cells and are widely used in in vitro studies of multidrug resistance(MDR). In this study, S1-M1-80 cell xenografts were established to investigate whether the MDR phenotype and cell biological properties were maintained in vivo. Our results showed that the proliferation, cell cycle, and ABCG2 expression level in S1-M1-80 cells were similar to those in cells isolated from S1-M1-80 cell xenografts (named xS1-M1-80 cells). Consistently, xS1-M1-80 cells exhibited high levels of resistance to ABCG2 substrates such as mitoxantrone and topotecan, but remained sensitive to the non-ABCG2 substrate cisplatin. Furthermore, the specific ABCG2 inhibitor Ko143 potently sensitized xS1-M1-80 cells to mitoxantrone and topotecan. These results suggest that S1-M1-80 cell xenografts in nude mice retain their original cytological characteristics at 9 weeks. Thus, this model could serve as a good system for further investigation of ABCG2-mediated MDR.

  3. Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression.

    Rafael Rosell

    Full Text Available BACKGROUND: Median survival is 10 months and 2-year survival is 20% in metastatic non-small-cell lung cancer (NSCLC treated with platinum-based chemotherapy. A small fraction of non-squamous cell lung cancers harbor EGFR mutations, with improved outcome to gefitinib and erlotinib. Experimental evidence suggests that BRCA1 overexpression enhances sensitivity to docetaxel and resistance to cisplatin. RAP80 and Abraxas are interacting proteins that form complexes with BRCA1 and could modulate the effect of BRCA1. In order to further examine the effect of EGFR mutations and BRCA1 mRNA levels on outcome in advanced NSCLC, we performed a prospective non-randomized phase II clinical trial, testing the hypothesis that customized therapy would confer improved outcome over non-customized therapy. In an exploratory analysis, we also examined the effect of RAP80 and Abraxas mRNA levels. METHODOLOGY/PRINCIPAL FINDINGS: We treated 123 metastatic non-squamous cell lung carcinoma patients using a customized approach. RNA and DNA were isolated from microdissected specimens from paraffin-embedded tumor tissue. Patients with EGFR mutations received erlotinib, and those without EGFR mutations received chemotherapy with or without cisplatin based on their BRCA1 mRNA levels: low, cisplatin plus gemcitabine; intermediate, cisplatin plus docetaxel; high, docetaxel alone. An exploratory analysis examined RAP80 and Abraxas expression. Median survival exceeded 28 months for 12 patients with EGFR mutations, and was 11 months for 38 patients with low BRCA1, 9 months for 40 patients with intermediate BRCA1, and 11 months for 33 patients with high BRCA1. Two-year survival was 73.3%, 41.2%, 15.6% and 0%, respectively. Median survival was influenced by RAP80 expression in the three BRCA1 groups. For example, for patients with both low BRCA1 and low RAP80, median survival exceeded 26 months. RAP80 was a significant factor for survival in patients treated according to BRCA1

  4. Efectos de los suplementos de proteína y aminoácidos de cadena ramificada en entrenamiento de fuerza: revisión bibliográfica

    Jordi Rabassa-Blanco

    2017-04-01

    Full Text Available Introducción: Los suplementos de proteína y aminoácidos de cadena ramificada (BCAAs son consumidos por la población buscando una serie de efectos fisiológicos y metabólicos sobre el rendimiento y recuperación, entre otros. Objetivos: Revisión de las publicaciones más recientes que estudien los efectos del consumo de suplementos de proteína y BCAAs en entrenamiento de fuerza en diferentes parámetros fisiológicos y metabólicos. Material y métodos: Estudio descriptivo de revisión bibliográfica. Se realizó una búsqueda específica de palabras clave en la base de datos PubMed y estrategia de bola de nieve. Criterios de inclusión: estudios realizados en humanos de ≥ 18 años sin patología, metaanálisis, revisiones sistemáticas y ensayos clínicos controlados aleatorizados en inglés y español relacionados con el consumo de suplementos de proteína y/o BCAAs en entrenamiento de fuerza y sus efectos sobre el daño muscular, respuesta anabólica en la recuperación muscular, ganancia de masa muscular y fuerza, composición corporal y fatiga. Resultados: 64 estudios identificados mediante la ecuación de búsqueda, 20 cumplieron con los criterios de inclusión. La media aritmética de los sujetos participantes fue igual a (30,59 ± 24,47. Conclusiones: Los suplementos de proteína podrían tener un efecto positivo en el aumento del rendimiento y la masa muscular, pero hacen falta más estudios para esclarecer su posible beneficio sobre la composición corporal, la fatiga, la atenuación y reducción del dolor y daño muscular. La leucina tiene efecto en el aumento de la masa muscular y su función en población de edad avanzada. Los BCAAs podrían actuar sobre la atenuación de la fatiga central y en la mejora del rendimiento.

  5. Influencia de la fuerza muscular isométrica de las extremidades superiores en el estrés oxidativo en niños. (Influence of handgrip strength in oxidative stress in children.

    Manuel Guillén-del Castillo

    2011-01-01

    Full Text Available ResumenEl ejercicio físico puede producir estrés oxidativo en el individuo lo que pueden condicionar el riesgo cardiovascular en niños y adolescentes. Este estudio pretende analizar el estrés oxidativo según la fuerza muscular isométrica de las extremidades superiores en la edad pediátrica. Se estudiaron 70 niños sanos con edades entre 10 y 14 años, y se analizaron en saliva los lipoperóxidos (LPO, el glutatión reducido (GSH, la ratio GSH/LPO y la catalasa, como marcadores de estrés oxidativo. La muestra se dividió en dos grupos según una condición física superior o inferior medida a través de dinamometría manual (TKK 5110; se diferenció la serie en sujetos prepuberales y puberales. Se encontraron niveles significativamente inferiores de GSH y GSH/LPO en el grupo de niños con fuerza superior, y en los puberales con la mismas características; estos resultados podrían indicar la existencia de un mayor estrés oxidativo en esta situación. En conclusión, los mayores niveles de fuerza músculo esquelética, medida a través de dinamometría manual, posiblemente pueden estar asociados a un mayor estrés oxidativo en niños púberes con condición física musculoesquelética superior.AbstractPhysical exercise can produce oxidative stress, this situation could contribute cardiovascular risk in children and adolescents. The following study tries to evaluate the oxidative stress produced according to the handgrip strength in infancy. 70 healthy male subjects, ages 10 to 14 years, were studied. In the saliva samples, lipoperoxides (LPO, reduced glutathione (GSH, glutathione/lipoperoxides ratio and catalase were analyzed as biomarkers of oxidative stress. Children were divided into two groups according to their handgrip strength (high or low measured by handgrip strength (TKK 5110. The groups were also divided into prepubertal and pubertal subjects. We found GSH’s significantly low levels and of GSH/LPO in pubertal group with high

  6. Construction of Eukaryotic Expression Vector with mBD1-mBD3 Fusion Genes and Exploring Its Activity against Influenza A Virus

    Wanyi Li

    2014-03-01

    Full Text Available Influenza (flu pandemics have exhibited a great threat to human health throughout history. With the emergence of drug-resistant strains of influenza A virus (IAV, it is necessary to look for new agents for treatment and transmission prevention of the flu. Defensins are small (2–6 kDa cationic peptides known for their broad-spectrum antimicrobial activity. Beta-defensins (β-defensins are mainly produced by barrier epithelial cells and play an important role in attacking microbe invasion by epithelium. In this study, we focused on the anti-influenza A virus activity of mouse β-defensin 1 (mBD1 and β defensin-3 (mBD3 by synthesizing their fusion peptide with standard recombinant methods. The eukaryotic expression vectors pcDNA3.1(+/mBD1-mBD3 were constructed successfully by overlap-PCR and transfected into Madin-Darby canine kidney (MDCK cells. The MDCK cells transfected by pcDNA3.1(+/mBD1-mBD3 were obtained by G418 screening, and the mBD1-mBD3 stable expression pattern was confirmed in MDCK cells by RT-PCR and immunofluorescence assay. The acquired stable transfected MDCK cells were infected with IAV (A/PR/8/34, H1N1, 0.1 MOI subsequently and the virus titers in cell culture supernatants were analyzed by TCID50 72 h later. The TCID50 titer of the experimental group was clearly lower than that of the control group (p < 0.001. Furthermore, BALB/C mice were injected with liposome-encapsulated pcDNA3.1(+/mBD1-mBD3 through muscle and then challenged with the A/PR/8/34 virus. Results showed the survival rate of 100% and lung index inhibitory rate of 32.6% in pcDNA3.1(+/mBD1-mBD3group; the TCID50 titer of lung homogenates was clearly lower than that of the control group (p < 0.001. This study demonstrates that mBD1-mBD3 expressed by the recombinant plasmid pcDNA3.1(+/mBD1-mBD3 could inhibit influenza A virus replication both in vitro and in vivo. These observations suggested that the recombinant mBD1-mBD3 might be developed into an agent for

  7. Effect of small addition of Mn on the passivation of Zn in 0.1 M NaOH solution

    Shang Xiuling; Zhang Bo; Han Enhou; Ke Wei

    2011-01-01

    The passivation of pure Zn (99.995 wt%) and Zn-0.4Mn (0.4 wt% Mn) alloy in a deaerated 0.1 M NaOH solution (pH 12.9) was investigated by electrochemical measurements, X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). The potentiodynamic polarization and electrochemical impedance measurements show that addition of 0.4 wt% Mn can decrease the passive current density of Zn in the passive region. XPS surface analysis indicates that there is approximately 1.0-2.0 at% Mn 2+ being incorporated into the passive film on Zn-0.4Mn alloy with Mn content being higher in the outer layers. Mott-Schottky analysis shows that the incorporated Mn can decrease concentration of defects in the film. AFM observations disclose that Mn can decrease the grain size of the film. The mechanism by which Mn additions improve the passivity of Zn is that the incorporated Mn can inhibit ions transportation in the film and inhibit its growth. Meanwhile, Mn can also promote the nucleation of Zn oxides and decrease film porosity.

  8. Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment.

    Al Shaimaa Hasan

    Full Text Available Cardiosphere-derived cells (CDCs, one of the promising stem cell sources for myocardial repair, have been tested in clinical trials and resulted in beneficial effects; however, the relevant mechanisms are not fully understood. In this study, we examined the hypothesis that CDCs favor heart repair by switching the macrophages from a pro-inflammatory phenotype (M1 into a regulatory anti-inflammatory phenotype (M2. Macrophages from mice were cultured with CDCs-conditioned medium or with fibroblasts-conditioned medium as a control. Immunostaining showed that CDCs-conditioned medium significantly enhanced the expression of CD206 (a marker for M2 macrophages, but decreased the expression of CD86 (a marker for M1 macrophages 3 days after culture. For animal studies, we used an acute myocardial infarction model of mice. We injected CDCs, fibroblasts, or saline only into the border zone of infarction. Then we collected the heart tissues for histological analysis 5 and 14 days after treatment. Compared with control animals, CDCs treatment significantly decreased M1 macrophages and neutrophils but increased M2 macrophages in the infarcted heart. Furthermore, CDCs-treated mice had reduced infarct size and fewer apoptotic cells compared to the controls. Our data suggest that CDCs facilitate heart repair by modulating M1/M2 macrophage polarization and neutrophil recruitment, which may provide a new insight into the mechanisms of stem cell-based myocardial repair.

  9. Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment

    Hasan, Al Shaimaa; Luo, Lan; Yan, Chen; Zhang, Tian-Xia; Urata, Yoshishige; Goto, Shinji; Mangoura, Safwat A.; Abdel-Raheem, Mahmoud H.; Zhang, Shouhua; Li, Tao-Sheng

    2016-01-01

    Cardiosphere-derived cells (CDCs), one of the promising stem cell sources for myocardial repair, have been tested in clinical trials and resulted in beneficial effects; however, the relevant mechanisms are not fully understood. In this study, we examined the hypothesis that CDCs favor heart repair by switching the macrophages from a pro-inflammatory phenotype (M1) into a regulatory anti-inflammatory phenotype (M2). Macrophages from mice were cultured with CDCs-conditioned medium or with fibroblasts-conditioned medium as a control. Immunostaining showed that CDCs-conditioned medium significantly enhanced the expression of CD206 (a marker for M2 macrophages), but decreased the expression of CD86 (a marker for M1 macrophages) 3 days after culture. For animal studies, we used an acute myocardial infarction model of mice. We injected CDCs, fibroblasts, or saline only into the border zone of infarction. Then we collected the heart tissues for histological analysis 5 and 14 days after treatment. Compared with control animals, CDCs treatment significantly decreased M1 macrophages and neutrophils but increased M2 macrophages in the infarcted heart. Furthermore, CDCs-treated mice had reduced infarct size and fewer apoptotic cells compared to the controls. Our data suggest that CDCs facilitate heart repair by modulating M1/M2 macrophage polarization and neutrophil recruitment, which may provide a new insight into the mechanisms of stem cell-based myocardial repair. PMID:27764217

  10. Dedicated sub 0.1 mSv 3DCT using MBIR in children with suspected craniosynostosis: quality assessment

    Ernst, Caroline W.; Hulstaert, Tine L.; Belsack, Dries; Buls, Nico; Gompel, Gert van; Nieboer, Koenraad H.; Verhelle, Filip; Maeseneer, Michel de; Mey, Johan de [Universitair Ziekenhuis Brussel, Department of Radiology, Brussels (Belgium); Buyl, Ronald [Vrije Universiteit Brussel, Department of Biomedical Statistics and Informatics, Brussels (Belgium)

    2016-03-15

    To retrospectively compare image quality of a lowered dose CT protocol to a standard CT protocol in children with suspicion of craniosynostosis. Forty-eight patients (age 0- 35 months), who presented with a cranial deformity underwent cranial 3D CT to assess sutural patency: between 2009 - 2010, 24 patients were imaged with a standard protocol (CTDIvol 32.18 mGy), from 2011-2012, 24 underwent a low dose protocol (0.94 mGy) combined with iterative reconstruction. Image quality was evaluated by both expert reading and objective analysis. Differences were assessed by independent t-test and Mann-Whitney U test, interreader agreement by Cohen's Kappa test. Effective dose of the low dose protocol was 0.08 mSv, corresponding to a reduction of 97 %. Image quality was similar in both groups in terms of overall diagnostic acceptability, objective noise measurements, subjective cranial bone edge sharpness and presence of artefacts. For objective sharpness of cranial bone-brain interface and subjective perception of noise, the images of the low dose protocol were superior. For all evaluated structures, interreader agreement was moderate to almost perfect. In the diagnosis of craniosynostosis in children with cranial deformities, a dedicated sub 0.1 mSv cranial 3DCT protocol can be used without loss in image quality. (orig.)

  11. Radial profiles of hard X-ray emission during steady state current drive in the TRIAM-1M tokamak

    Nakamura, Y.; Takabatake, Y.; Jotaki, E.; Moriyama, S.; Nagao, A.; Nakamura, K.; Hiraki, N.; Itoh, S.

    1990-01-01

    The hard X-ray emission from the TRIAM-1M tokamak plasma during steady state lower hybrid current drive with a discharge duration of a few minutes was measured with sodium iodide scintillation spectrometers. The radial profiles of the X-ray emission were also measured and indicate that, in the low density regime (n e =(1-3)x10 12 cm -3 ), the current carrying high energy electrons are mainly in the inner region of the plasma column and their radial profile remains unchanged during current drive. On the other hand, high density discharges (n e =(3-6)x10 12 cm -3 ) are always accompanied by an abrupt drop of the plasma current, and the X-ray emission profile changes from peaked to broad. This change can be attributed to the conditions of wave accessibility. As the electron density increases, the accessibility of the plasma to lower hybrid waves with low values of the parallel wave number n parallel is significantly reduced and high energy electrons resonating with the waves are produced at the plasma periphery. Interaction of these electrons with the limiters causes an increase of the electron density in this region; waves with low n parallel then become completely excluded from the inner part of the plasma column. This interpretation is supported by measurements of the density profile and impurity radiation, and has been confirmed in an investigation of discharges with additional gas puffing. (author). 17 refs, 21 figs

  12. Status of prompt gamma neutron activation analysis (PGAA) at TRR-1/M1 (Thai Research Reactor-1/Modified 1)

    Asvavijnijkulchai, Chanchai; Dharmavanij, Wanchai; Siangsanan, Pariwat; Ratanathongchai, Wichian; Chongkum, Somporn [Physics Division, Office of Atomic Energy for Peace, Vibhavadi Rangsit Road, Chatuchak, Bangkok (Thailand)

    1999-08-01

    The first prompt gamma activation analysis (PGAA) was designed, constructed and installed at a 6 inch diameter neutron beam port of the Thai Research Reactor-1/Modified 1 (TRR-1/M1) since 1989. Beam characteristic were made by Gd foil irradiation, X-ray film exposing and densitometry scanning consequently. The thermal neutron flux at sample position was measured by Au foil activation, and was about 1 x 10{sup 7} n.cm{sup 2}.sec{sup -1} at 700 kW operating power. The experiments have been conducted successfully. In 1998, the PGAA facility has been developed for the reactor operating power at 1.2 MW. The new PGAA system, e.g., beam shutter, gamma collimator and biological shields have been designed to reduce the leakage of neutrons and gamma radiation to the acceptance levels in accordance with the International Commission on Radiation Protection Publication 60 (ICRP 60). The construction and installation will be completed in April 1999. (author)

  13. Corrosion inhibition of Eleusine aegyptiaca and Croton rottleri leaf extracts on cast iron surface in 1 M HCl medium

    Rajeswari, Velayutham; Kesavan, Devarayan; Gopiraman, Mayakrishnan; Viswanathamurthi, Periasamy; Poonkuzhali, Kaliyaperumal; Palvannan, Thayumanavan

    2014-01-01

    Graphical abstract: - Highlights: • Eleusine aegyptiaca and Croton rottleri are commonly available, less-toxic and eco-friendly inhibitors for cast iron corrosion. • The active constituents present in extracts adsorbed on the iron surface to inhibit the acidic corrosion. • The higher values of E a and ΔH * point out the higher inhibition efficiency noticed for the inhibitors. • Weight loss methods at various temperature and spectral data provides evidence for adsorption mechanism of inhibitors. - Abstract: The adsorption and corrosion inhibition activities of Eleusine aegyptiaca (E. aegyptiaca) and Croton rottleri (C. rottleri) leaf extracts on cast iron corrosion in 1 M hydrochloric acid solution were studied first time by weight loss and electrochemical techniques viz., Tafel polarization and electrochemical impedance spectroscopy. The results obtained from the weight loss and electrochemical methods showed that the inhibition efficiency increased with inhibitor concentrations. It was found that the extracts acted as mixed-type inhibitors. The addition of halide additives (KCl, KBr, and KI) on the inhibition efficiency has also been investigated. The adsorption of the inhibitors on cast iron surface both in the presence and absence of halides follows the Langmuir adsorption isotherm model. The inhibiting nature of the inhibitors was supported by FT-IR, UV–vis, Wide-angle X-ray diffraction and SEM methods

  14. Continuous and real-time data acquisition system for superconducting tokamaks HT-7 and TRIAM-1M

    Wang, F.; Luo, J.R.; Nakamura, K.; Sato, K.N.; Hanada, K.; Sakamoto, M.; Idei, H.; Kawasaki, S.; Nakashima, H.

    2006-01-01

    Conventional data acquisition systems cannot deal with data acquisition for a long-time discharge of a nuclear fusion reactor. Thus, continuous data acquisition with a real-time data presentation during discharge must be developed. Two data acquisition systems, which include alternating CAMAC data acquisition and long-time PCI data acquisition, are designed for the long-time operation of HT-7 tokamak. Since an effective alternating mode is adopted, the alternating CAMAC data acquisition can accurately and continuously acquire data at a rate of 10 kHz. The acquired data is immediately transmitted to a data server and real-time results can be presented during the plasma discharge. As for the long-time PCI data acquisition, a special kind of PCI A/D card, which has a hard disk on board, is designed to collect data at a max speed of 200 kHz. Thus, the total sampling duration is only related to the capacity of the hard disk on board. These two types of data acquisitions were applied to HT-7 tokamak and a 250 s discharge was acquired. These data acquisition systems were also successfully demonstrated on a 2500 s plasma discharge on TRIAM-1M. This paper describes the two data acquisitions in detail

  15. Molecular dynamic and quantum chemical calculations for phthalazine derivatives as corrosion inhibitors of mild steel in 1 M HCl

    Musa, Ahmed Y., E-mail: AMUSA6@UWO.CA [Department of Chemistry, University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 5B7 (Canada); Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia, Bangi, 43600 Selangor (Malaysia); Jalgham, Ramzi T.T.; Mohamad, Abu Bakar [Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia, Bangi, 43600 Selangor (Malaysia)

    2012-03-15

    Highlights: Black-Right-Pointing-Pointer The inhibition of three phthalazine derivatives was studied. Black-Right-Pointing-Pointer The inhibition efficiency increased in the following order: PTD < PT < PTO. Black-Right-Pointing-Pointer The adsorption energies were calculated using molecular dynamics simulations. Black-Right-Pointing-Pointer Quantum chemical parameters were calculated using the AM1, MNDO and PM3 methods. Black-Right-Pointing-Pointer The adsorption of phthalazine derivatives obeys the Langmuir adsorption isotherm. - Abstract: The abilities of phthalazine derivatives, including phthalazine (PT), phthalazone (PTO) and phthalhydrazide (PTD), to inhibit the corrosion of mild steel in 1 M HCl at 30 Degree-Sign C were studied using electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization measurements. Theoretical calculations were performed to investigate the electronic structures of the PT derivatives. Our results showed that the inhibition efficiencies of these derivatives improved with increases in concentration. The data also showed that PTD < PT < PTO in terms of the inhibiting efficiency. Theoretical calculations also revealed that PTO is expected to be the best inhibitor among the studied phthalazine derivatives.

  16. Polyomavirus BK replication in renal transplant recipients: combined monitoring of viremia and VP1 mRNA in urine

    Sara Astegiano

    2010-06-01

    Full Text Available Introduction. Human polyomavirus BK (BKV is worldwide distributed, with a seroprevalence rate of 70–90% in the adults. Following primary infection, BK remains latent in the renourinary tract as the epidemiologically most relevant latency site, and in B cell, brain, spleen and probably other tissues. Reactivation may occur in both immunocompetent subjects and immunocompromised patients. In renal transplantation, in the context of intense immunosuppression, viral replication may determine BKV-associated nephropathy (BKVAN with interstitial nephritis and/or ureteral stenosis in 1–10% of the patients and leading to graft failure and return to haemodialysis in 30 to 80% of the cases (5. Screening of BKV replication represents the basic strategy to predict early the onset of BKVAN and may allow for earlier intervention with reduced allograft loss (3, 4. Nowadays, replication of BKV is monitored by quantification of BKV-DNA in serum and urine (2. The aim of this study was to evaluated the role of BKV VP1 mRNA in urine as a marker of viral replication in renal transplant recipients.

  17. The WA105-3x1x1 m3 dual phase LAr-TPC demonstrator

    Murphy, Sebastien

    2016-11-15

    The dual phase Liquid Argon Time Projection Chamber (LAr TPC) is the state-of-art technology for neutrino detection thanks to its superb 3D tracking and calorimetry performance. Its main feature is the charge amplification in gas argon which provides excellent signal-to-noise ratio. Electrons produced in the liquid argon are extracted in the gas phase. Here, a readout plane based on Large Electron Multiplier detectors provides amplification of the charges before its collection onto an anode with strip readout. The charge amplification enables constructing fully homoge- nous giant LAr-TPCs with tuneable gain, excellent charge imaging performance and increased sensitivity to low energy events. Following a staged approach the WA105 collaboration is con- structing a dual phase LAr-TPC with an active volume of 3x1x1m3 that will soon be tested with cosmic rays. Its construction and operation aims to test scalable solutions for the crucial aspects of this technology: ultra high argon purity in non-evacuable tank, la...

  18. Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion.

    Yesenia Ríos

    2011-01-01

    Full Text Available Loss of retinoblastoma (Rb tumor suppressor function is associated with human malignancies. Molecular and genetic mechanisms responsible for tumorigenic Rb downregulation are not fully defined. Through a forward genetic screen and positional cloning, we identified and characterized a zebrafish ubiquitin specific peptidase 39 (usp39 mutation, the yeast and human homolog of which encodes a component of RNA splicing machinery. Zebrafish usp39 mutants exhibit microcephaly and adenohypophyseal cell lineage expansion without apparent changes in major hypothalamic hormonal and regulatory signals. Gene expression profiling of usp39 mutants revealed decreased rb1 and increased e2f4, rbl2 (p130, and cdkn1a (p21 expression. Rb1 mRNA overexpression, or antisense morpholino knockdown of e2f4, partially reversed embryonic pituitary expansion in usp39 mutants. Analysis of pre-mRNA splicing status of critical cell cycle regulators showed misspliced Rb1 pre-mRNA resulting in a premature stop codon. These studies unravel a novel mechanism for rb1 regulation by a neuronal mRNA splicing factor, usp39. Zebrafish usp39 regulates embryonic pituitary homeostasis by targeting rb1 and e2f4 expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators. These results provide a mechanism for dysregulated rb1 and e2f4 pathways that may result in pituitary tumorigenesis.

  19. La coactivación del bíceps femoral limita la fuerza máxima isométrica de extensión de rodilla en ciclistas de ruta

    García-López, David; Bresciani, Guilherme; Cabeza de Vaca, Salvador; Garatachea, Nuria; De Paz, José

    2006-01-01

    Introducción y objetivos: El objeto del presente estudio fue analizar la coactivación antagonista (bíceps femoral) durante una contracción máxima isométrica de extensión unilateral de rodilla, en ciclistas de ruta, así como su relación con la activación agonista (recto femoral, vasto medial y vasto lateral) y la fuerza manifestada. La activación de los músculos gastrocnemios también fue monitorizada. Métodos: Dieciséis ciclistas federados efectuaron una prueba máxima de extensión isométr...

  20. El papel del razonamiento analógico en la construcción histórica de la noción de fuerza gravitatoria y del modelo de Sistema Solar (I Parte

    Oliva, J.Mª.

    2004-01-01

    Full Text Available En este artículo, junto a otro que tenemos en preparación, se revisa la importancia del pensamiento analógico en la construcción histórica de la noción de fuerza gravitatoria y del modelo del Sistema Solar. Concretamente, en este primer artículo se empiezan analizando las ideas surgidas al respecto desde las civilizaciones más antiguas, incluida la griega, hasta las aportaciones de figuras como Copérnico, Kepler o el propio Galileo, en los albores de la revolución copernicana. En el otro, pendiente de publicar en un próximo número, se discuten algunos de los razonamientos analógicos formulados con posterioridad a partir de la segunda mitad del siglo XVII y que culminaría con la síntesis newtoniana.

  1. Evaluación técnica informática de los procesos de gobierno de TI (Evaluar, Orientar y Supervisar) al sistema de información de la Universidad de las Fuerzas Armadas "ESPE". Sede Principal

    Guanotuña Lascano, Emily Jeanette; Chávez Ñauñay, Carlos Patricio

    2016-01-01

    La Evaluación Técnica Informática de los Procesos de Gobierno de TI al Sistema de Información de la Universidad de las Fuerzas Armadas ESPE Matriz, utiliza el marco de referencia COBIT 5 e identifica los procesos más críticos de la Institución a través de una matriz de riesgo elaborada de acuerdo a los criterios establecidos en este marco de referencia. Se elabora un programa detallado de Auditoría, mediante una matriz de investigación de campo, en la que se detalla el objeto del análisis, lo...

  2. La imposibilidad de un ejército profesional: Ramón de Cáceres y el establecimiento de procedimientos burocráticos en las fuerzas del Río de la Plata. 1810-1830

    Alejandro M. Rabinovich

    2013-01-01

    Full Text Available El presente artículo aborda la problemática de la profesionalización de las fuerzas militares del Estado rioplatense independiente a partir de un ángulo muy poco analizado hasta hoy: los intentos de establecer procedimientos burocráticos y un tipo particular de disciplina en el seno de unidades combatientes surgidas de una intensa movilización popular.Primero se analizarán las reglamentaciones que regían la administración de los ejércitos, con especial énfasis en la descripción del tipo de funcionariado que era buscado por los modelos europeos de la época. Luego, este deber serde la administración militar será confrontado con el estudio de un caso puntual: el traumático intento de transformación de los Dragones Libertadores surgidos del alzamiento de la campaña oriental en 1825 en Regimiento de Caballería de Línea, ocurrido en el seno del Ejército Republicano que se aprestaba para abrir la guerra con el Brasil. Este modesto episodio, explorado a través de las memorias personales del oficial a cargo de llevar adelante la reforma del cuerpo, nos permitirá echar luz sobre las limitaciones concretas encontradas en el terreno por aquellos funcionarios que hablaban en nombre del Estado y pretendían someter a las fuerzas de un pueblo en armas a una lógica procedimental- formal.

  3. Valoración de la influencia de la práctica del fútbol en la evolución de la fuerza, la flexibilidad y la velocidad en población infantil

    Silvia Sedano Campo*

    2007-03-01

    Full Text Available El objetivo del estudio es valorar la influencia que la práctica regular del fútbol tiene sobre algunos aspectos de la condición física (fuerza explosiva del tren inferior, flexibilidad y velocidad en niños de entre 7 y 14 años. Por otro lado también pretendemos determinar la correlación existente entre las tres capacidades evaluadas, comparar los resultados con población infantil general y analizar las posibles influencias que la práctica de este deporte puede tener en el desarrollo evolutivo. La muestra se compone de 106 niños que practican fútbol federado en clubes de la comunidad de Castilla y León. En primer lugar determinamos el peso y la talla de cada participante en el estudio y posteriormente pasamos tres pruebas de valoración de la condición física que forman parte de la batería EUROFIT: Flexión de tronco desde posición de sentados, salto horizontal y carrera de 10 X 5 m ida y vuelta. Se observa la importante influencia que la práctica del fútbol tiene en la flexibilidad y la velocidad cuando comparamos los datos con los obtenidos en escolares de la misma comunidad autónoma. Se observa también la correlación fuerte y positiva existente entre la fuerza y la velocidad

  4. Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1.

    Gokhan Demirkan

    Full Text Available Our understanding of signal transduction networks in the physiological context of an organism remains limited, partly due to the technical challenge of identifying serine/threonine phosphorylated peptides from complex tissue samples. In the present study, we focused on signaling through the mammalian target of rapamycin (mTOR complex 1 (mTORC1, which is at the center of a nutrient- and growth factor-responsive cell signaling network. Though studied extensively, the mechanisms involved in many mTORC1 biological functions remain poorly understood.We developed a phosphoproteomic strategy to purify, enrich and identify phosphopeptides from rat liver homogenates. Using the anticancer drug rapamycin, the only known target of which is mTORC1, we characterized signaling in liver from rats in which the complex was maximally activated by refeeding following 48 hr of starvation. Using protein and peptide fractionation methods, TiO(2 affinity purification of phosphopeptides and mass spectrometry, we reproducibly identified and quantified over four thousand phosphopeptides. Along with 5 known rapamycin-sensitive phosphorylation events, we identified 62 new rapamycin-responsive candidate phosphorylation sites. Among these were PRAS40, gephyrin, and AMP kinase 2. We observed similar proportions of increased and reduced phosphorylation in response to rapamycin. Gene ontology analysis revealed over-representation of mTOR pathway components among rapamycin-sensitive phosphopeptide candidates.In addition to identifying potential new mTORC1-mediated phosphorylation events, and providing information relevant to the biology of this signaling network, our experimental and analytical approaches indicate the feasibility of large-scale phosphoproteomic profiling of tissue samples to study physiological signaling events in vivo.

  5. SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients

    Taka C

    2017-11-01

    Full Text Available Chihiro Taka, Ryuji Hayashi, Kazuki Shimokawa, Kotaro Tokui, Seisuke Okazawa, Kenta Kambara, Minehiko Inomata, Toru Yamada, Shoko Matsui, Kazuyuki Tobe First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Sugitani, Toyama, Toyama, Japan Background: Physical activity (PA is considered as one of the most important prognostic predictors in chronic obstructive pulmonary disease (COPD patients. Longevity gene, SIRT1, is reported to be involved in the pathogenesis of COPD by regulating the signaling pathways of oxidative stress, inflammation, and aging. We hypothesize that SIRT1 and related genes are also associated with the benefits of PA in COPD patients.Methods: Eighteen COPD outpatients were enrolled in this study, and their PA level was assessed with an accelerometer. We assessed the SIRT1 and related genes mRNA expression levels in the peripheral blood mononuclear cells (PBMCs of the subjects. We carried out respiratory function testing, blood gas analysis, the 6-minute walk test, and measurement of the cross-sectional area of the erector spinae muscles (ESMCSA by chest computed tomography. We analyzed the association of PA with the results of each of the examinations.Results: The mean age was 72±9 years, and the mean forced expiratory volume in 1 second was 1.4±0.56 L (52%±19% predicted. Our findings revealed a correlation between the daily PA and ESMCSA. The SIRT1 and Forkhead box O (FOXO1 mRNA expression levels in PBMCs were positively correlated with moderate-PA time (r=0.60, p=0.008 for SIRT1 and r=0.59, p=0.01 for FOXO1. Keywords: COPD, accelerometer, mRNA, walking, sedentary, moderate

  6. Effect of Different Welding Processes on Electrochemical and Corrosion Behavior of Pure Nickel in 1 M NaCl Solution

    Xijing Wang

    2017-11-01

    Full Text Available A plasma arc welding (PAW-tungsten inert gas (TIG hybrid welding process is proposed to weld pure nickel. In PAW-TIG welding, the arc of the PAW was first to be ignited, then TIG was ignited, while in PAW welding, only the PAW arc was launched. This paper investigated the effect of different welding processes on electrochemical and corrosion performance of between a pure nickel joint and a base metal in an aerated 1 M NaCl solution, respectively. The average grain size of the joint fabricated by PAW welding (denoted as JP joint is 463.57 μm, the joint fabricated by PAW-TIG welding(denoted as JP-T joint is 547.32 μm, and the base metal (BM is 47.32 μm. In this work, the passivity behaviors of samples were characterized for two welding processes by electrochemical impedance spectroscopy (EIS, open circuit potential versus immersion time (OCP-t, and the potentiodynamic polarization plots. EIS spectra, attained with different immersion times, were analyzed and fitted by an equivalent electrical circuit. Photomicrographs of BM, JP, and JP-T were also taken with a scanning electron microscope (SEM to reveal the morphological structure of the pit surfaces. Electrochemical tests show that the sequence of the corrosion resistance is BM > JP > JP-T. The size and quantity of the hemispherical corrosion pits of all samples are different. The corrosion morphology observations found a consistency with the consequence of the electrochemical measurements. The results show that an increase of the grain dimensions due to different heat treatments decreased the pure nickel stability to pitting corrosion.

  7. Vapour pressures of selected organic compounds down to 1 mPa, using mass-loss Knudsen effusion method

    Fonseca, José M.S.; Gushterov, Nikola; Dohrn, Ralf

    2014-01-01

    Graphical abstract: - Highlights: • A recently described mass-loss Knudsen apparatus was used for measurements of vapour pressures down to around 1 mPa. • Complementary calorimetric studies were performed in a Calvet-type calorimeter. • New vapour pressures are given for benzoic acid and benzanthrone, in ranges in which no consistent data existed. • Vapour pressures for solid n-octadecane are presented, correcting existing values from literature. - Abstract: A recently developed Knudsen effusion apparatus was improved and used for measurements of vapour pressures of selected organic compounds. Calorimetric studies were conducted using a Calvet-type calorimeter, complementing the information obtained for the vapour pressures and facilitating the modelling and analysis of the data. Vapour pressures of benzoic acid, a reference substance, were determined at temperatures between 269 K and 317 K, corresponding to a pressure range from 2 mPa to 1 Pa, extending the range of results available in the literature to lower pressures. Benzanthrone was studied between temperatures 360 K and 410 K (5 mPa–1 Pa) in order to test the apparatus at higher temperatures. Values presented in the literature for the vapour pressure of solid n-octadecane, one of the most promising compounds to be used as “phase change material” for textile applications, were found inconsistent with the triple point of the substance. Sublimation pressures were measured for this compound between T = 286 K and 298 K (2–20 mPa) allowing the correction of the existing values. Finally, vapour pressures of diphenyl carbonate, a compound of high industrial relevance for its use in the production of polycarbonates, were determined from T = 302 K to 332 K (0.02–1 Pa)

  8. Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).

    Shibutani, Shusaku; Okazaki, Hana; Iwata, Hiroyuki

    2017-11-03

    The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of protein synthesis and potential target for modifying cellular metabolism in various conditions, including cancer and aging. mTORC1 activity is tightly regulated by the availability of extracellular amino acids, and previous studies have revealed that amino acids in the extracellular fluid are transported to the lysosomal lumen. There, amino acids induce recruitment of cytoplasmic mTORC1 to the lysosome by the Rag GTPases, followed by mTORC1 activation by the small GTPase Ras homolog enriched in brain (Rheb). However, how the extracellular amino acids reach the lysosomal lumen and activate mTORC1 remains unclear. Here, we show that amino acid uptake by dynamin-dependent endocytosis plays a critical role in mTORC1 activation. We found that mTORC1 is inactivated when endocytosis is inhibited by overexpression of a dominant-negative form of dynamin 2 or by pharmacological inhibition of dynamin or clathrin. Consistently, the recruitment of mTORC1 to the lysosome was suppressed by the dynamin inhibition. The activity and lysosomal recruitment of mTORC1 were rescued by increasing intracellular amino acids via cycloheximide exposure or by Rag overexpression, indicating that amino acid deprivation is the main cause of mTORC1 inactivation via the dynamin inhibition. We further show that endocytosis inhibition does not induce autophagy even though mTORC1 inactivation is known to strongly induce autophagy. These findings open new perspectives for the use of endocytosis inhibitors as potential agents that can effectively inhibit nutrient utilization and shut down the upstream signals that activate mTORC1. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes

    Yu-Miao Wei

    2013-06-01

    Full Text Available Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes (CAMs to thereby exert their beneficial effects in atherosclerosis. Methods and Results: Using flow cytometry, we demonstrated that simvastatin significantly increased the autophagsome formation in CAMs. Western blot analysis confirmed that simvastatin significantly increased protein expression of typical autophagy markers LC3B and Beclin1 in these CAMs. Confocal microscopy further demonstrated that simvastatin increased fusion of autophagosomes with lysosomes, which was blocked by autophagy inhibitor 3-methyladenine or silencing of Atg7 genes. Simvastatin reduced mammalian target of rapamycin (mTOR activity, which was reversed by Rac1-GTPase overexpression and the mTOR agonist phosphatidic acid. Moreover, both Rac1-GTPase overexpression and activation of mTOR by phosphatidic acid drastically blocked simvastatin-induced autophagosome formation in CAMs. Interestingly, simvastatin increased protein expression of a contractile phenotype marker calponin in CAMs, which was blocked by autophagy inhibitor 3-methyladenine. Simvastatin markedly reduced proliferation of CAMs under both control and proatherogenic stimulation. However, this inhibitory effect of simvastatin on CAM proliferation was blocked by by autophagy inhibitor 3-methyladenine or silencing of Atg7 genes. Lastly, animal experiments demonstrated that simvastatin increased protein expression of LC3B and calponin in mouse coronary arteries. Conclusion: Our results indicate that simvastatin inhibits the Rac1-mTOR pathway and thereby increases autophagy in CAMs which may stabilize CAMs in the contractile phenotype to prevent proliferation and growth

  10. A High Performance Computing Approach to Tree Cover Delineation in 1-m NAIP Imagery Using a Probabilistic Learning Framework

    Basu, Saikat; Ganguly, Sangram; Michaelis, Andrew; Votava, Petr; Roy, Anshuman; Mukhopadhyay, Supratik; Nemani, Ramakrishna

    2015-01-01

    Tree cover delineation is a useful instrument in deriving Above Ground Biomass (AGB) density estimates from Very High Resolution (VHR) airborne imagery data. Numerous algorithms have been designed to address this problem, but most of them do not scale to these datasets, which are of the order of terabytes. In this paper, we present a semi-automated probabilistic framework for the segmentation and classification of 1-m National Agriculture Imagery Program (NAIP) for tree-cover delineation for the whole of Continental United States, using a High Performance Computing Architecture. Classification is performed using a multi-layer Feedforward Backpropagation Neural Network and segmentation is performed using a Statistical Region Merging algorithm. The results from the classification and segmentation algorithms are then consolidated into a structured prediction framework using a discriminative undirected probabilistic graphical model based on Conditional Random Field, which helps in capturing the higher order contextual dependencies between neighboring pixels. Once the final probability maps are generated, the framework is updated and re-trained by relabeling misclassified image patches. This leads to a significant improvement in the true positive rates and reduction in false positive rates. The tree cover maps were generated for the whole state of California, spanning a total of 11,095 NAIP tiles covering a total geographical area of 163,696 sq. miles. The framework produced true positive rates of around 88% for fragmented forests and 74% for urban tree cover areas, with false positive rates lower than 2% for both landscapes. Comparative studies with the National Land Cover Data (NLCD) algorithm and the LiDAR canopy height model (CHM) showed the effectiveness of our framework for generating accurate high-resolution tree-cover maps.

  11. Electron cyclotron current drive experiments in LHCD plasmas using a remote steering antenna on the TRIAM-1M tokamak

    Idei, H.; Hanada, K.; Zushi, H.; Ohkubo, K.; Hasegawa, M.; Kubo, S.; Nishi, S.; Fukuyama, A.; Sato, K.N.; Nakamura, K.; Sakamoto, M.; Iyomasa, A.; Kawasaki, S.; Nakashima, H.; Higashijima, A.; Notake, T.; Shimozuma, T.; Ito, S.; Hoshika, H.; Maezono, N.; Nakashima, K.; Ogawa, M.

    2006-01-01

    A remote steering antenna was recently developed for electron cyclotron heating and current drive (ECH/ECCD) experiments on the TRIAM-1M tokamak. This is the first application of the remote steering antenna concept for ECH/ECCD experiments, which have conditions relevant to the International Thermonuclear Experimental Reactor (ITER). Fundamental ECH and ECCD experiments were conducted in the ITER frequency from the low field using this antenna system. In addition to the angles near 0 0 , the launcher was a symmetric direction antenna with an extended steering-angle capability of ±(8 0 -19 0 ). The output beam from the antenna was a well-defined Gaussian with a proper steering angle. The Gaussian content and the steering-angle accuracy were 0.85 and -0.5 0 , respectively. The high power tests measured the antenna transmission efficiency at 0.90-0.94. The efficiencies obtained in the low and high power tests were consistent with the calculations using higher-order modes. In order to excite the pure O/X-modes in the oblique injection, two polarizers were used to control the elliptical polarization of the incident beam for the ECCD experiments. The fundamental O/X-mode ECH/ECCD was applied to lower hyrid current drive plasmas at the optimized incident polarization. In the X-mode experiment, at medium density (∼1 x 10 19 m -3 ), clear differences in the plasma current and the hard x-ray intensity were observed between the co- and counter-steering injections due to the ECCD effect on the coupling of forward fast electrons

  12. A High Performance Computing Approach to Tree Cover Delineation in 1-m NAIP Imagery using a Probabilistic Learning Framework

    Basu, S.; Ganguly, S.; Michaelis, A.; Votava, P.; Roy, A.; Mukhopadhyay, S.; Nemani, R. R.

    2015-12-01

    Tree cover delineation is a useful instrument in deriving Above Ground Biomass (AGB) density estimates from Very High Resolution (VHR) airborne imagery data. Numerous algorithms have been designed to address this problem, but most of them do not scale to these datasets which are of the order of terabytes. In this paper, we present a semi-automated probabilistic framework for the segmentation and classification of 1-m National Agriculture Imagery Program (NAIP) for tree-cover delineation for the whole of Continental United States, using a High Performance Computing Architecture. Classification is performed using a multi-layer Feedforward Backpropagation Neural Network and segmentation is performed using a Statistical Region Merging algorithm. The results from the classification and segmentation algorithms are then consolidated into a structured prediction framework using a discriminative undirected probabilistic graphical model based on Conditional Random Field, which helps in capturing the higher order contextual dependencies between neighboring pixels. Once the final probability maps are generated, the framework is updated and re-trained by relabeling misclassified image patches. This leads to a significant improvement in the true positive rates and reduction in false positive rates. The tree cover maps were generated for the whole state of California, spanning a total of 11,095 NAIP tiles covering a total geographical area of 163,696 sq. miles. The framework produced true positive rates of around 88% for fragmented forests and 74% for urban tree cover areas, with false positive rates lower than 2% for both landscapes. Comparative studies with the National Land Cover Data (NLCD) algorithm and the LiDAR canopy height model (CHM) showed the effectiveness of our framework for generating accurate high-resolution tree-cover maps.

  13. Effective conductivity and permittivity of unsaturated porous materials in the frequency range 1 mHz–1GHz

    Revil, A

    2013-01-01

    A model combining low-frequency complex conductivity and high-frequency permittivity is developed in the frequency range from 1 mHz to 1 GHz. The low-frequency conductivity depends on pore water and surface conductivities. Surface conductivity is controlled by the electrical diffuse layer, the outer component of the electrical double layer coating the surface of the minerals. The frequency dependence of the effective quadrature conductivity shows three domains. Below a critical frequency fp, which depends on the dynamic pore throat size Λ, the quadrature conductivity is frequency dependent. Between fp and a second critical frequency fd, the quadrature conductivity is generally well described by a plateau when clay minerals are present in the material. Clay-free porous materials with a narrow grain size distribution are described by a Cole-Cole model. The characteristic frequency fd controls the transition between double layer polarization and the effect of the high-frequency permittivity of the material. The Maxwell-Wagner polarization is found to be relatively negligible. For a broad range of frequencies below 1 MHz, the effective permittivity exhibits a strong dependence with the cation exchange capacity and the specific surface area. At high frequency, above the critical frequency fd, the effective permittivity reaches a high-frequency asymptotic limit that is controlled by the two Archie's exponents m and n like the low-frequency electrical conductivity. The unified model is compared with various data sets from the literature and is able to explain fairly well a broad number of observations with a very small number of textural and electrochemical parameters. It could be therefore used to interpret induced polarization, induction-based electromagnetic methods, and ground penetrating radar data to characterize the vadose zone. PMID:23576823

  14. Influence of 8-aminoquinoline on the corrosion behaviour of copper in 0.1 M NaCl

    Cubillos, M.; Sancy, M.; Pavez, J.; Vargas, E.; Urzua, R.; Henriquez-Roman, J.; Tribollet, B.; Zagal, J.H.; Paez, M.A.

    2010-01-01

    The corrosion behaviour of copper in aerated 0.1 M NaCl solution in presence of 8-aminoquinoline (8-AQ), using open circuit potential (OCP) measurements, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) measurements and atomic force microscopy (AFM), was studied. The measurements revealed that the effect of 8-AQ is dependent on its concentration. For concentrations up to 10 -3 M, the organic compound displaces the corrosion potential following no trend and also reduces the anodic current. In contrast, for concentrations higher than 10 -3 , 8-AQ reduces markedly both, the anodic and cathodic currents and consequently, the corrosion current density of copper. After 9 days of exposure in chloride solution, containing the organic compound, potentiodynamic polarization analyses showed a significant reduction in the anodic response and a less significant reduction in the cathodic response, which is associated with a film formed at the copper surface of about 10 μm in thickness and visually observed by a colour change of the copper surface. In order to elucidate the most likely interaction between the 8-AQ molecule and the different molecular structures probably present on copper surfaces in chloride solutions, some results obtained from theoretical calculations are presented. The following molecular structures were considered: CuCl molecule, CuCl 2 - complex, and little copper clusters defect representation built as five atoms on C 4v symmetry. Thus, based on the geometric, energetic, frontier orbital, and Total Electronic Density analysis done for the optimized states found for the systems investigated, we suggest that the most probable interaction of 8-AQ proceeds above CuCl units and free copper sites.

  15. Binding of DEAD-box helicase Dhh1 to the 5'-untranslated region of ASH1 mRNA represses localized translation of ASH1 in yeast cells.

    Zhang, Qianjun; Meng, Xiuhua; Li, Delin; Chen, Shaoyin; Luo, Jianmin; Zhu, Linjie; Singer, Robert H; Gu, Wei

    2017-06-09

    Local translation of specific mRNAs is regulated by dynamic changes in their subcellular localization, and these changes are due to complex mechanisms controlling cytoplasmic mRNA transport. The budding yeast Saccharomyces cerevisiae is well suited to studying these mechanisms because many of its transcripts are transported from the mother cell to the budding daughter cell. Here, we investigated the translational control of ASH1 mRNA after transport and localization. We show that although ASH1 transcripts were translated after they reached the bud tip, some mRNAs were bound by the RNA-binding protein Puf6 and were non-polysomal. We also found that the DEAD-box helicase Dhh1 complexed with the untranslated ASH1 mRNA and Puf6. Loss of Dhh1 affected local translation of ASH1 mRNA and resulted in delocalization of ASH1 transcript in the bud. Forcibly shifting the non-polysomal ASH1 mRNA into polysomes was associated with Dhh1 dissociation. We further demonstrated that Dhh1 is not recruited to ASH1 mRNA co-transcriptionally, suggesting that it could bind to ASH1 mRNA within the cytoplasm. Of note, Dhh1 bound to the 5'-UTR of ASH1 mRNA and inhibited its translation in vitro These results suggest that after localization to the bud tip, a portion of the localized ASH1 mRNA becomes translationally inactive because of binding of Dhh1 and Puf6 to the 5'- and 3'-UTRs of ASH1 mRNA. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  16. Characterization and distribution of GHRH, PACAP, TRH, SST and IGF1 mRNAs in the green iguana.

    Ávila-Mendoza, José; Pérez-Rueda, Ernesto; Urban-Sosa, Valeria; Carranza, Martha; Martínez-Moreno, Carlos G; Luna, Maricela; Arámburo, Carlos

    2018-01-01

    The somatotropic axis (SA) regulates numerous aspects of vertebrate physiology such as development, growth, and metabolism and has influence on several tissues including neural, immune, reproductive and gastric tract. Growth hormone (GH) is a key component of SA, it is synthesized and released mainly by pituitary somatotrophs, although now it is known that virtually all tissues can express GH, which, in addition to its well-described endocrine roles, also has autocrine/paracrine/intracrine actions. In the pituitary, GH expression is regulated by several hypothalamic neuropeptides including GHRH, PACAP, TRH and SST. GH, in turn, regulates IGF1 synthesis in several target tissues, adding complexity to the system since GH effects can be exerted either directly or mediated by IGF1. In reptiles, little is known about the SA components and their functional interactions. The aim of this work was to characterize the mRNAs of the principal SA components in the green iguana and to develop the tools that allow the study of the structural and functional evolution of this system in reptiles. By employing RT-PCR and RACE, the cDNAs encoding for GHRH, PACAP, TRH, SST and IGF1 were amplified and sequenced. Results showed that these cDNAs coded for the corresponding protein precursors of 154, 170, 243, 113, and 131 amino acids, respectively. Of these, GHRH, PACAP, SST and IGF1 precursors exhibited a high structural conservation with respect to its counterparts in other vertebrates. On the other hand, iguana's TRH precursor showed 7 functional copies of mature TRH (pyr-QHP-NH 2 ), as compared to 4 and 6 copies of TRH in avian and mammalian proTRH sequences, respectively. It was found that in addition to its primary production site (brain for GHRH, PACAP, TRH and SST, and liver for IGF1), they were also expressed in other peripheral tissues, i.e. testes and ovaries expressed all the studied mRNAs, whereas TRH and IGF1 mRNAs were observed ubiquitously in all tissues considered. These

  17. China Dimensions Data Collection: China County-Level Data on Population (Census) and Agriculture, Keyed to 1:1M GIS Map

    National Aeronautics and Space Administration — China County-Level Data on Population (Census) and Agriculture, Keyed To 1:1M GIS Map consists of census, agricultural economic, and boundary data for the...

  18. China Dimensions Data Collection: China County-Level Data from Provincial Economic Yearbooks, Keyed to 1:1M GIS Map

    National Aeronautics and Space Administration — China County-Level Data on Provincial Economic Yearbooks, Keyed To 1:1M GIS Map consists of socioeconomic and boundary data for the administrative regions of China...

  19. Ectopic expression and knocking-down of LINE-1 mRNA in human mesenchymal stem cells: impact on in vitro osteogenic and adipogenic differentiation

    Atinbayeva, Nazerke

    2018-01-01

    on the acquisition of a terminally differentiated phenotype. In contrast, soon after MSCs commitment into pre-osteoblasts, L1 retrotransposable elements increase their expression and actively transpose. Inhibition of retrotransposition and knock down of L1 m

  20. Geology of the Alarcón Rise Based on 1-m Resolution Bathymetry and ROV Observations and Sampling

    Clague, D. A.; Caress, D. W.; Lundsten, L.; Martin, J. F.; Paduan, J. B.; Portner, R. A.; Bowles, J. A.; Castillo, P. R.; Dreyer, B. M.; Guardado-France, R.; Nieves-Cardoso, C.; Rivera-Huerta, H.; Santa Rosa-del Rio, M.; Spelz-Madero, R.

    2012-12-01

    Alarcón Rise is a ~50 km-long segment of the northernmost East Pacific Rise, bounded on the north and south by the Pescadero and Tamayo Fracture Zones. In April 2012, the MBARI AUV D. Allan B. completed a 1.5-3.1-km wide bathymetric map along the neovolcanic zone between the two fracture zones during 10 surveys. A single AUV survey was also completed on Alarcón Seamount, a near-ridge seamount with 4 offset calderas. Bathymetric data have 1 m lateral and 0.2 m vertical resolution. The maps guided 8 dives of the ROV Doc Ricketts on the ridge and 1 on the seamount. The morphology of the rise changes dramatically along strike and includes an inflated zone, centered ~14 km from the southern end, paved by a young sheet flow erupted from an 8-km-long en echelon fissure system. A young flat-topped volcano and an older shield volcano occur near the center of the ridge segment. Areas nearer the fracture zones are mainly pillow mounds and ridges, some strongly cut by faults and fissures, but others have few structural disruptions. More than 150 of the 194 lava samples recovered from the neovolcanic zone are aphyric to plagioclase-phyric to ultraphyric N-MORB with glass MgO ranging up to 8.5%. The basal cm from 87 short cores contain common limu o Pele and adequate foramifers to provide minimum radiocarbon ages for the underlying lava flows. A rugged lava dome of rhyolite (based on glass compositions) is surrounded by large pillow flows of dacite, centered ~8 km from the north end of the Rise. Pillow flows are steeply uptilted for 2-3 km north and south of the dome, possibly reflecting intrusion of viscous rhyolitic dikes along strike. Near the southern end of this deformed zone, an andesite flow crops out in a fault scarp. Mapping data also reveal the presence of about 110 apparent hydrothermal chimney structures as tall as 18 m, scattered along roughly the central half of the Rise. Subsequent ROV dives observed 70 of these structures and found active venting at 22 of them

  1. New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74.

    Pearson, Mark S; Jariwala, Amar R; Abbenante, Giovanni; Plieskatt, Jordan; Wilson, David; Bottazzi, Maria Elena; Hotez, Peter J; Keegan, Brian; Bethony, Jeffrey M; Loukas, Alex

    2015-01-01

    Na-APR-1(M74) is an aspartic protease that is rendered enzymatically inactive by site-directed mutagenesis and is a candidate antigen component in the Human Hookworm Vaccine. The mutant protease exerts vaccine efficacy by inducing antibodies that neutralize the enzymatic activity of wild type enzyme (Na-APR-1wt) in the gut of the hookworm, thereby depriving the worm of its ability to digest its blood meal. Previously, canines immunized with Na-APR-1(M74) and challenged with Ancylostoma caninum were partially protected against hookworm challenge infection, especially from the loss in hemoglobin observed in control canines and canine immunoglobulin (Ig) G raised against Na-APR-1 was shown to inhibit the enzymatic activity of Na-APR-1 wt in vitro, thereby providing proof of concept of Na-APR-1(M74) as a vaccine antigen. The mutated version, Na-APR-1(M74), was then expressed at the cGMP level using a Nicotiana benthamiana expression system (Fraunhofer, CMB, Delaware, MD), formulated with Alhydrogel®, and used to immunize mice in a dose-ranging study to explore the enzyme-neutralizing capacity of the resulting anti- Na-APR-1(M74) IgG. As little as 0.99 μg of recombinant Na-APR-1(M74) could induce anti Na-APR-1(M74) IgG in mice that were capable of inhibiting Na-APR-1w t-mediated digestion of a peptide substrate by 89%. In the absence of enzymatic activity of Na-APR-1(M74) as a surrogate marker of protein functionality, we developed an assay based on the binding of a quenched fluorescence-labeled inhibitor of aspartic proteases, BODIPY-FL pepstatin A (BDP). Binding of BDP in the active site of Na-APR-1 wt was demonstrated by inhibition of enzymatic activity, and competitive binding with unlabelled pepstatin A. BDP also bound to Na-APR-1(M74) which was assessed by fluorescence polarization, but with an ∼ 50-fold reduction in the dissociation constant. Taken together, these assays comprise a "toolbox" that could be useful for the analyses of Na-APR-1(M74) as it

  2. The Prognostic Relevance of Sentinel Lymph Node Metastases Assessed by PHGR1 mRNA Quantification in Stage I to III Colon Cancer

    Satu Oltedal

    2018-04-01

    Full Text Available BACKGROUND: Regional lymph node (LN metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph node (SLN metastases in colon cancer patients by measuring the novel metastasis marker PHGR1 mRNA. METHODS: Using quantitative reverse-transcription polymerase chain reaction, we measured PHGR1 mRNA levels in SLNs and primary tumors from 206 patients surgically treated for stage I to III colon cancer and 52 normal LNs from patients undergoing surgery for benign colon diseases. The prognostic impact of these findings was evaluated by Kaplan-Meier analysis and Cox proportional-hazards regression. RESULTS: Compared to normal LNs, elevated PHGR1 mRNA levels were detected in SLNs from 56 (89% of the 63 patients with pN+ disease. Furthermore, 68 (48% of the 143 node-negative (pN0 patients had elevated PHGR1 mRNA levels in SLNs, suggesting occult metastases. With a median follow-up of 7.2 years, a significantly shorter recurrence-free (P=.005 and disease-specific (P=.02 survival was observed in patients with elevated PHGR1 mRNA levels in SLNs. Multivariable modeling showed that the SLN PHGR1 mRNA level was an independent prognostic factor. However, when the survival analyses were restricted to pN0 patients, no significant prognostic information was found. CONCLUSION: Measuring PHGR1 mRNA in SLNs provided independent prognostic information on operable colon cancer patients but not in the pN0 subgroup.

  3. Effects of a newly developed potent orexin-2 receptor-selective antagonist Compound1m on sleep/wake states in mice

    Keishi eEtori

    2014-01-01

    Full Text Available Orexins (also known as hypocretins, which are hypothalamic neuropeptides, play critical roles in the regulation of sleep/wakefulness states by activating two G-protein coupled receptors (GPCRs, orexin 1 (OX1R and orexin 2 receptors (OX2R. In order to know the difference between effects of OX2R-selective antagonists (2-SORA and dual orexin receptor antagonists (DORA, and to understand the mechanisms underlying orexin-mediated regulation of sleep/wakefulness states, we examined the effects of a newly developed 2-SORA, Compound 1m (C1m, and a DORA, suvorexant, on sleep/wakefulness states in C57BL/6J mice. After oral administration in the dark period, both C1m and suvorexant exhibited potent sleep-promoting properties with similar efficacy in a dose-dependent manner. While C1m did not increase NREM and REM sleep episode durations, suvorexant induced longer episode durations of NREM and REM sleep as compared with both the vehicle- and C1m-administered groups. When compounds were injected during light period, C1m did not show a significant change in sleep/wakefulness states in the light period, whereas suvorexant slightly but significantly increased the sleep time. We also found that C1m did not affect the time of REM sleep, while suvorexant markedly increased it. This suggests that although OX1R-mediated pathway plays a pivotal role in promoting wakefulness, OX1R-mediated pathway also plays an additional role. OX1R-mediated pathway also plays a role in suppression of REM sleep. Fos-immunostaining showed that both compounds affected the activity of arousal-related neurons with different patterns. These results suggest partly overlapping and partly distinct roles of orexin receptors in the regulation of sleep/wakefulness states.

  4. The cysteine 34 residue of A1M/α1-microglobulin is essential for protection of irradiated cell cultures and reduction of carbonyl groups.

    Rutardottir, S; Nilsson, E J C; Pallon, J; Gram, M; Åkerström, B

    2013-07-01

    α1-microglobulin (A1M) is a 26 kDa plasma and a tissue protein belonging to the lipocalin family. The reductase and free radical scavenger A1M has been shown to protect cells and extracellular matrix against oxidative and irradiation-induced damage. The reductase activity was previously shown to depend upon an unpaired cysteinyl side-chain, C34, and three lysyl side-chains, K92, 118, and 130, located around the open end of the lipocalin pocket. The aim of this work was to investigate whether the cell and matrix protection by A1M is a result of its reductase activity by using A1M-variants with site-directed mutations of the C34, K92, K118, and K130 positions. The results show that the C34 side-chain is an absolute requirement for protection of HepG2 cell cultures against alpha-particle irradiation-induced cell death, upregulation of stress response and cell cycle regulation genes. Mutation of C34 also resulted in loss of the reduction capacity toward heme- and hydrogen peroxide-oxidized collagen, and the radical species 2,2´-azino-bis (3-ethyl-benzo-thiazoline-6-sulphonic acid) (ABTS). Furthermore, mutation of C34 significantly suppressed the cell-uptake of A1M. The K92, K118, and K130 side-chains were of minor importance in cell protection and reduction of oxidized collagen but strongly influenced the reduction of the ABTS-radical. It is concluded that antioxidative protection of cells and collagen by A1M is totally dependent on its C34 amino acid residue. A model of the cell protection mechanism of A1M should be based on the redox activity of the free thiolyl group of the C34 side-chain and a regulatory role of the K92, K118, and K130 residues.

  5. Dilemas políticos y de orden público: Alcaldías y fuerzas de seguridad en disturbios etnicistas Dilemas políticos y de orden público: Alcaldías y fuerzas de seguridad en disturbios etnicistas

    MANUEL ÁNGEL Río Ruiz

    2005-01-01

    Full Text Available A través de entrevistas y de la explotación de diversas fuentes documentales, se analiza el papel de autoridades locales y fuerzas de seguridad en localidades españolas donde, se han producido casos de violencia colectiva focalizados en miembros de minorías culturales estigmatizadas, como gitanos e inmigrantes. Las ilustraciones desplegadas, analizadas atendiendo a los hallazgos sustantivos de la literatura sociológica e historiográfica sobre relaciones interétnicas y represión estatal de la protesta, muestran la frecuente inobservancia, por parte de los dispositivos estatales de coerción, de principios básicos de la moderna doctrina de la represión preventiva que, en cambio, sí se aplican de manera recurrente a la hora del manejo policial de otras protestas sociales. A su vez, en lo que respecta a las autoridades municipales, el análisis muestra las constricciones que encuentran estas agencias de control y poder comunitario a la hora de la contención de multitudes etnicistas. El análisis revela que la posición de puente entre las dos comunidades que ocupan las autoridades locales, así como la frecuente implicación de los alcaldes en los agravios y tensiones que anteceden a los conflictos, limita la eficacia de éstos en el manejo pacífico de protestas e iniciativas colectivas etnicistas a las que, por otra parte, ediles de diverso signo político han prestado, a veces, una colaboración planeada o sobrevenida, como sucediera en los casos de Mancha Real o El Ejido, también abordados aquíThis paper analyses the role of local authorities and police forces in the development of several cases of collective violence against stigmatised minorities, such as gypsies and immigrants, that have taken place in Spain during the last two decades. The research is based in ethnographical interviews and secondary sources. The several cases are analysed taking into account the sociological and historical literature that deal with inter

  6. Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy

    Kim Kyung-Jong

    2008-08-01

    Full Text Available Abstract Background The membrane transporters such as P-glycoprotein (Pgp, the MDR1 gene product, are one of causes of treatment failure in cancer patients. In this study, the epigenetic mechanisms involved in differential MDR1 mRNA expression were compared between 10 gastric and 9 colon cancer cell lines. Methods The MDR1 mRNA levels were determined using PCR and real-time PCR assays after reverse transcription. Cytotoxicity was performed using the MTT assay. Methylation status was explored by quantification PCR-based methylation and bisulfite DNA sequencing analyses. Results The MDR1 mRNA levels obtained by 35 cycles of RT-PCR in gastric cancer cells were just comparable to those obtained by 22 cycles of RT-PCR in colon cancer cells. Real-time RT-PCR analysis revealed that MDR1 mRNA was not detected in the 10 gastric cancer cell lines but variable MDR1 mRNA levels in 7 of 9 colon cancer cell lines except the SNU-C5 and HT-29 cells. MTT assay showed that Pgp inhibitors such as cyclosporine A, verapamil and PSC833 sensitized Colo320HSR (colon, highest MDR1 expression but not SNU-668 (gastric, highest and SNU-C5 (gastric, no expression to paclitaxel. Quantification PCR-based methylation analysis revealed that 90% of gastric cancer cells, and 33% of colon cancer cells were methylated, which were completely matched with the results obtained by bisulfite DNA sequencing analysis. 5-aza-2'-deoxcytidine (5AC, a DNA methyltransferase inhibitor increased the MDR1 mRNA levels in 60% of gastric cells, and in 11% of colon cancer cells. Trichostatin A (TSA, histone deacetylase inhibitor increased the MDR1 mRNA levels in 70% of gastric cancer cells and 55% of colon cancer cells. The combined treatment of 5AC with TSA increased the MDR1 mRNA levels additively in 20% of gastric cancer cells, but synergistically in 40% of gastric and 11% of colon cancer cells. Conclusion These results indicate that the MDR1 mRNA levels in gastric cancer cells are significantly

  7. Relationship between test of postural control and strength and ability tests in basketball players. [Relación entre las pruebas de control postural y las pruebas de fuerza y habilidad en jugadores de baloncesto].

    Abbas Asadi

    2018-04-01

    Full Text Available Abstract This study investigated the relationship between performance tests (i.e., jumping ability, strength, sprint and change of direction ability and dynamic postural control in young basketball players. Twenty-three young basketball players participated in this study and performed measurements of dynamic balance (Star Excursion Balance Test [SEBT], countermovement jump (CMJ, broad long jump (BLJ, 4×9-m shuttle run, agility T test (TT, Illinois agility test (IAT, 20-m sprint and lower extremity muscle strength. Significant association was observed between balance (at medial direction and strength performance (r = 0.523, p < 0.05. Significant positive correlations were detected between directions of SEBT and BLJ (r = -0.466 to -0.479, p < 0.05, 4×9-m shuttle run (r = -0.403 to 0.486, p < 0.05, TT (r = -0.410, p < 0.05, IAT (r = 0.435, p < 0.05 and sprint (r = -0.402 to 0.452, p < 0.05. Postural control is more in relation to change of direction ability, sprint and power performance in basketball athletes. Resumen Este estudio investigó la relación entre las pruebas de rendimiento y el control postural dinámico en jóvenes jugadores de baloncesto. Veintitrés jóvenes jugadores de baloncesto participaron en este estudio y realizaron mediciones de equilibrio dinámico (Prueba de Balance de Excursión Estrella [SEBT], salto de contramovimiento (CMJ, salto largo en longitud (BLJ, lanzamiento de 4 × 9 m, test T de agilidad (TT, prueba de agilidad de Illinois (IAT, sprint de 20 m y fuerza muscular de las extremidades inferiores. Se observó una asociación significativa entre el equilibrio (en la dirección medial y el rendimiento de la fuerza (r = 0.523, p <0.05. Se detectaron correlaciones positivas significativas entre las direcciones de SEBT y BLJ (r = -0,466 a -0,479, p <0,05, carrera con cambios de sentido de 4 × 9 m (r = -0,403 a 0,486, p <0,05, TT (r = 0,410, p <0,05, IAT (r = 0,435, p <0,05 y sprint (r = -0,402 a 0,452, p <0,05. El

  8. The effect of co-deposition of hydrogen and metals on wall pumping in long duration plasma in TRIAM-1M

    Miyamoto, M.; Tokitani, M.; Tokunaga, K.; Fujiwara, T.; Yoshida, N.; Sakamoto, M.; Zushi, H.; Nagata, S.; Ono, K.

    2005-01-01

    The effect of co-deposition on recycling and wall pumping during long duration plasmas in TRIAM-1M has been studied. To examine the hydrogen retention on the all metal walls, material exposure experiments were carried out using an ultra-long discharge for about 72 min. After exposure to the plasma, the surface modification and hydrogen retention of the specimens were examined quantitatively by means of ion beam analysis techniques and transmission electron microscopy (TEM). Large amount of retained hydrogen were detected in the specimen exposed to the long duration discharge in TRIAM-1M. This amount was sufficient to explain the wall pumping in TRIAM-1M. A correlation was also observed between the thicknesses of the deposits and the amount of retained hydrogen. These results mean that the metallic deposited layer can trap a large amount of hydrogen and has a strong influence on hydrogen recycling similar to a carbon deposit

  9. Correlation between spermatogenesis disorders and rat testes CYP2E1 mRNA contents under experimental alcoholism or type I diabetes.

    Shayakhmetova, Ganna M; Bondarenko, Larysa B; Matvienko, Anatoliy V; Kovalenko, Valentina M

    2014-09-01

    The aim of the study was to investigate the correlation between spermatogenesis disorders and CYP2E1 mRNA contents in testes of rats with experimental alcoholism or type I diabetes. Two pathological states characterized by CYP2E1 induction were simulated on Wistar male rats: experimental alcoholism and type I diabetes. As controls for each state, equal number of animals (of the same age and weight) were used. Morphological evaluation of rat testes was carried out. The spermatogenic epithelium state was estimated by four points system. CYP2E1 mRNA expression was rated by method of reverse transcriptase polymerase chain reaction. Pearson correlation coefficients were used for describing relationships between variables. The presence of alcoholism and diabetes-mediated quantitative and qualitative changes in male rat spermatogenic epithelium in comparison with norm has been demonstrated. The increased levels of testes CYP2E1 have been fixed simultaneously. CYP2E1 mRNA content negatively strongly correlated with spermatogenic index value (r=-0.99; Palcoholism. The strong correlation between CYP2E1 mRNA content and number of spermatogonia (r=0.99; P<0.001) and "windows" occurrence (r=0.96; P<0.001) has been fixed in diabetic rats testes. Present investigation has demonstrated that the testicular failure following chronic ethanol consumption and diabetes type I in male rats accompanied CYP2E1 mRNA over-expression in testes. The correlation between the levels of CYP2E1 mRNA in testes and spermatogenesis disorders allow supposing the involvement of CYP2E1 into the non-specific pathogenetic mechanisms of male infertility under above-mentioned pathologies. Copyright © 2014 Medical University of Bialystok. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  10. Diversification of the vacAs1m1 and vacAs2m2 strains of Helicobacter pylori in Meriones unguiculatus

    Sandra Mendoza Elizalde

    2016-11-01

    Full Text Available The bacterium Helicobacter pylori exhibits great genetic diversity, and the pathogenic roles of its virulence factors have been widely studied. However, the evolutionary dynamics of H. pylori strains during stomach colonization are not well characterized. Here, we analyzed the microevolutionary dynamics of the toxigenic strain vacAs1m1, the non-toxigenic strain vacAs2m2, and a combination of both strains in an animal model over time. Meriones unguiculatus were inoculated with the following bacteria: group 1–toxigenic strain vacAs1m1/cagA+/cagE+/babA2+; ST181, group 2–non-toxigenic strain vacAs2m2/ cagA+/ cagE+/ babA2+; ST2901, and group 3–both strains. The gerbils were euthanized at different time points (3, 6, 12 and 18 months. In group 1, genetic alterations were observed at 6 and 12 months. With the combination of both strains, group 3 also exhibited genetic alterations at 3 and 18 months; moreover, a chimera, vacA m1-m2, was detected. Additionally, four new sequence types (STs were reported in the PubMLST database for H. pylori. Synonymous and non-synonymous mutations were analyzed and associated with alterations in amino acids. Microevolutionary analysis of the STs (PHYLOViZ identified in each group revealed many mutational changes in the toxigenic (vacAs1m1 and non-toxigenic (vacAs2m2 strains. Phylogenetic assessments (eBURST did not reveal clonal complexes. Our findings indicate that the toxigenic strain, vacAs1m1, and a combination of toxigenic and non-toxigenic strains acquired genetic material by recombination. The allelic combination, vacAs2m1, displayed the best adaptation in the animal model over time, and a chimera, m1-m2, was also identified, which confirmed previous reports.

  11. Cytochrome P450 1B1 mRNA levels in peripheral blood cells and exposure to polycyclic aromatic hydrocarbons in Chinese coke oven workers

    Hanaoka, Tomoyuki; Tsugane, Shoichiro [Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, 6-5-1 Kashiwanoha, Kashiwa-shi, 277-8577 Chiba (Japan); Yamano, Yuko; Kagawa, Jun [Tokyo Womens' Medical University, 8-1 Kawadacho, Shinjuku-ku, 162-8666 Tokyo (Japan); Pan, Guowei; Zhang, Shujuan [Liaoning Provincial Center for Disease Prevention and Control, 42-1 Jixian Street, 110005 Shenyang (China); Hara, Kunio [Institute for Science of Labour, 2-8-14 Miyamae-ku, 216-8501 Kawasaki (Japan); Ichiba, Masayoshi; Zhang, Jiusong [Saga Medical School, 5-1 Nabeshima, Saga-shi, 849-8501 Saga (Japan); Liu, Tiefu; Li, Landi [Angang Public Health and Anti-epidemic Station Lishan District, 23 Shengoushi Yutian Street, 114034 Anshan (China); Takahashi, Ken [University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555 Kitakyushu (Japan)

    2002-09-16

    Cytochrome P450 1B1 (CYP1B1) is induced through the Ah receptor and is involved in the activation of polycyclic aromatic hydrocarbons (PAHs). To determine the validity of a quantitative analysis of CYP1B1 mRNA in peripheral human blood cells for the estimation of PAH exposure, a real-time quantitative polymerase chain reaction method was used to measure the relative levels of CYP1B1 mRNA in 37 Chinese coke oven workers and 13 control workers. A large inter-individual difference in the levels was observed. The average level of the CYP1B1 mRNA in workers at the top work site, where the PAH exposure level from the coke ovens was highest, was significantly higher than in workers at the middle site (P<0.01) or the controls (P=0.02). A non-significant positive correlation was found between the CYP1B1 mRNA levels and urinary 1-hydroxypyrene (R=0.22, P=0.13), and a significant correlation between these mRNA levels and urinary cotinine (R=0.33, P=0.02). It was interesting that a significant positive correlation between CYP1B1 mRNA and 1-hydroxypyrene was observed in subjects with the Leu/Leu type of CYP1B1 Leu432Val polymorphism (R=0.33, P=0.02, n=38) and a non-significant correlation in subjects with the Leu/Val and Val/Val types (R=-0.36, P=0.25, n=12), although the number of subjects in this strata analysis was small. Our preliminary study suggests that PAH exposure in coke ovens and smoking maybe associated with CYP1B1 mRNA levels in peripheral blood cells although mRNA is generally unstable and could be expressed following exposure to other agents.

  12. Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters.

    Chandra, Vikas; Das, Tapojyoti; Gulati, Puneet; Biswas, Nidhan K; Rote, Sarang; Chatterjee, Uttara; Ghosh, Samarendra N; Deb, Sumit; Saha, Suniti K; Chowdhury, Anup K; Ghosh, Subhashish; Rudin, Charles M; Mukherjee, Ankur; Basu, Analabha; Dhara, Surajit

    2015-01-01

    Hedgehog (Hh) signaling pathway is a valid therapeutic target in a wide range of malignancies. We focus here on glioblastoma multiforme (GBM), a lethal malignancy of the central nervous system (CNS). By analyzing RNA-sequencing based transcriptomics data on 149 clinical cases of TCGA-GBM database we show here a strong correlation (r = 0.7) between GLI1 and PTCH1 mRNA expression--as a hallmark of the canonical Hh-pathway activity in this malignancy. GLI1 mRNA expression varied in 3 orders of magnitude among the GBM patients of the same cohort showing a single continuous distribution-unlike the discrete high/low-GLI1 mRNA expressing clusters of medulloblastoma (MB). When compared with MB as a reference, the median GLI1 mRNA expression in GBM appeared 14.8 fold lower than that of the "high-Hh" cluster of MB but 5.6 fold higher than that of the "low-Hh" cluster of MB. Next, we demonstrated statistically significant up- and down-regulation of GLI1 mRNA expressions in GBM patient-derived low-passage neurospheres in vitro by sonic hedgehog ligand-enriched conditioned media (shh-CM) and by Hh-inhibitor drug vismodegib respectively. We also showed clinically achievable dose (50 μM) of vismodegib alone to be sufficient to induce apoptosis and cell cycle arrest in these low-passage GBM neurospheres in vitro. Vismodegib showed an effect on the neurospheres, both by down-regulating GLI1 mRNA expression and by inducing apoptosis/cell cycle arrest, irrespective of their relative endogenous levels of GLI1 mRNA expression. We conclude from our study that this single continuous distribution pattern of GLI1 mRNA expression technically puts almost all GBM patients in a single group rather than discrete high- or low-clusters in terms of Hh-pathway activity. That is suggestive of therapies with Hh-pathway inhibitor drugs in this malignancy without a need for further stratification of patients on the basis of relative levels of Hh-pathway activity among them.

  13. Bone marrow-derived and peritoneal macrophages have different inflammatory response to oxLDL and M1/M2 marker expression

    Bisgaard, Line S; Mogensen, Christina K; Rosendahl, Alexander

    2016-01-01

    Macrophages are heterogeneous and can polarize into specific subsets, e.g. pro-inflammatory M1-like and re-modelling M2-like macrophages. To determine if peritoneal macrophages (PEMs) or bone marrow derived macrophages (BMDMs) resembled aortic macrophages from ApoE-/- mice, their M1/M2 phenotype,......, ACSL1, SRB1, DGAT1, and cpt1a) was decreased in advanced versus early lesions. In conclusion, PEMs and BMDMs are phenotypically distinct and differ from macrophages in lesions with respect to expression of M1/M2 markers and lipid metabolism genes....

  14. M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis

    Shoichi Fukui

    2018-01-01

    Full Text Available ObjectivesWe investigated the relationships among M1 monocytes, M2 monocytes, osteoclast (OC differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (RA.MethodsPeripheral blood mononuclear cells (PBMCs were isolated from RA patients and healthy donors, and we then investigated the number of M1 monocytes or M2 monocytes by fluorescence-activated cell sorting. We also obtained and cultured CD14-positive cells from PBMCs from RA patients and healthy donors to investigate OC differentiation in vitro.ResultsForty RA patients and 20 healthy donors were included. Twenty-two patients (55% were anticitrullinated protein antibody (ACPA positive. The median M1/M2 ratio was 0.59 (0.31–1.11, interquartile range. There were no significant differences between the RA patients and healthy donors. There was a positive correlation between the M1/M2 ratio and the differentiated OC number in vitro in RA patients (ρ = 0.81, p < 0.001. The ACPA-positive patients had significantly higher M1/M2 ratios in vivo (p = 0.028 and significantly greater numbers of OCs in vitro (p = 0.005 than the ACPA-negative patients. Multivariable regression analysis revealed that the M1/M2 ratio was the sole significant contribution factor to in vitro osteoclastogenesis. RA patients with M1/M2 ratios >1 (having relatively more M1 monocytes had higher C-reactive protein and erythrocyte sedimentation rates than RA patients with M1/M2 ratios ≤1. M1-dominant monocytes in vitro produced higher concentrations of interleukin-6 upon stimulation with lipopolysaccharide than M2 monocytes.ConclusionM1/M2 monocytes imbalance strongly contributes to osteoclastogenesis of RA patients. Our findings cast M1 and M2 monocyte subsets in a new light as a new target of treatments for RA to prevent progression of osteoclastic bone destruction.

  15. Effects on the improvement and retention strength of two training programs with regular and concentrated loads in subjects untrained Efectos sobre la mejora y retención de la fuerza de dos programas de entrenamiento con cargas regulares y concentradas en sujetos

    F. Navarro

    2010-09-01

    Full Text Available

    In this study it is compared the improvement and retention of the maximum dynamic strength in 35 subjects untrained, after the application of two training programs of equal content and different loads distribution (with/without concentration of loads = SC/CC so that in one of the programs the double of total volume takes place. Measurements from high maximum weight in 1RM, maximum strength, and total average strength were taken, with the system of measurement of dynamic forces ISOCONTROL 3.6., in the exercise of squat (SQ, before (PRE -, and at the end of the treatment (POST 1, as well as after 1 (POST 2 and 2 months (POST 3 of its conclusion. Both groups improved the maximum dynamic strength of highly significant form (p<0.01 during the cycle of training (29% SC - 36% CC, not existing significant differences between groups in any of the measured variables. In conclusion, after 8 weeks of strength training, the maximum dynamic strength of significant form highly in subjects untrained can be improved, and similars gains are obtained, as much with a distribution of concentrated loads, like with a distribution without concentration of loads where half of volume has been made that in the previous one.432
    KEY WORDS: Training, strength, distribution of loads, volume.

     

    En este estudio se compara la mejora y retención de la fuerza dinámica máxima en 35 sujetos no entrenados, tras la aplicación de dos programas de entrenamiento de igual contenido y diferente distribución de la carga (sin/con concentración de cargas =SC/CC de forma que en uno de los programas se efectúa el doble de volumen total. Se tomaron mediciones de peso máximo elevado en 1RM, fuerza máxima, y fuerza media total, con el sistema de medición de fuerzas dinámicas ISOCONTROL 3.6., en el ejercicio de squat (SQ, antes (PRE-, y al final del tratamiento (POST

  16. Acerca de la dimensión histórico-política del trabajo en clave estatal. Gestión de la Fuerza de Trabajo en la ¿burocracia? provincial correntina

    Valeria Ojeda

    2016-01-01

    Full Text Available Este artículo busca recuperar algunos aspectos relevantes que conforman la dimensión histórico-política del trabajo en el Estado provincial correntino. Apartir de un análisis que pone en relieve las características del sistema de gestión de la fuerza de trabajo estatal, en este recorte nos enfocaremos en discutir cómo tales elementos influyen, impactan y van otorgando diversidad de sentido a la gestión de los trabajadores. Se trata de un trabajo que apunta a situar un espacio laboral cruzado por una multiplicidad de intereses, sobre el cual circulan nociones de sentido común fuertemente arraigadas tanto en la sociedad como en la misma academia. Asimismo, su valor también reside en la posibilidad de poner en un marco analítico el desarrollo de las burocracias subnacionales, con sus peculiaridades y sus sentidos “nativos”, alejándonos de la acrítica aplicación de modelos teóricos prevalentes y permitiendo la apertura a nuevas categorías de análisis.

  17. A propósito de “El cuerpo como máquina. La medicalización de la fuerza de trabajo en Chile”. Sobre el dispositivo médico y su alcance

    Hugo Nicolás Sir Retamales

    2014-04-01

    Full Text Available En la siguiente reseña, se hace referencia al libro del autor Nicolás Fuster “El cuerpo como máquina. La medicalización de la fuerza de trabajo en Chile”, publicado en Santiago de Chile el año 2013 por la editorial Ceibo. El presente trabajo constituye una modificación a la presentación del libro, y se exponen en él argumentos centrales del libro, con una lógica argumentativa que intenta mostrar la relevancia a su vez como fuente documental, y como principio de interrogación a las problemáticas actuales, respecto a las formas de gobierno contemporáneas. Una de los elementos a los que se arriba es la ambivalencia que encierra el proceso de medicalización, como bien sucede con el despliegue de otros dispositivos, entre las instancias de control heterónomo, y las posibilidades auformativas no totalmente cooptadas, que dan espacio a relaciones diversas con la institucionalidad, y por tanto, lugar para modificar los dispositivos

  18. Trabajo no remunerado y reproductivo. ¿Quién debe de pagar la reproducción de la fuerza de trabajo de una nación?

    Alicia Girón

    2016-01-01

    Full Text Available Se aborda el problema de ¿Quién debe de pagar el costo de la reproducción de la fuerza del trabajo de una nación? en relación a la ampliación de la participación de las mujeres en el mercado laboral y el desdibujamiento del Estado del Bienestar, de la cual surge la preocupación sobre el trabajo desempeñado por las mujeres en la unidad familiar. Además examina la búsqueda por contabilizar el trabajo no remunerado. A lo largo de las últimas cuatro décadas las crisis recurrentes han sido la consecución de frecuentes planes de estabilización, reestructuración y renegociaciones de los créditos con acreedores e inversionistas financieros institucionales en los mercados financieros. La orientación del gasto público al pago del servicio de la deuda y a los compromisos de los países con el exterior han ido mermando la capacidad del gasto público principalmente en cuanto al gasto social como el gasto en educación y el gasto en salud. Lo ha impactado en las políticas públicas. Un agradecimiento a Andrea Reyes, becaria del Consejo Nacional de Ciencias y Tecnología (CONACYT, por la recopilación del material para este trabajo.

  19. Consideraciones para el rediseño de la línea de ensamble de vehículos aéreos no tripulados desarrollados por la Fuerza Aérea Ecuatoriana

    Ricardo Daniel Fiallos Castillo

    2016-01-01

    Full Text Available Este trabajo tiene como objetivo el re-diseño de la línea de ensamblaje de los vehículos aéreos no tripulados (por siglas en inglés, UAVs destinados a realizar diversas misiones a grandes alturas llevadas a cabo en el Centro de Investigación y Desarrollo de la Fuerza Aérea Ecuatoriana (CIDFAE. La metodología que se aplicó consta de tres fases: la primera comprende el análisis de la situación estratégica actual; la segunda estima la capacidad del proceso productivo con el uso de las normas de tiempo predeterminadas en base al sistema MTM-2; la tercera realiza el estudio de la distribución de las instalaciones mediante simulación. Como resultado final se opta por una distribución mixta que garantiza una producción en serie de UAVs. La construcción de piezas se realiza en células de fabricación; y el ensamble final por estaciones de trabajo; además se establecen estrategias para el fortalecimiento de la capacidad operativa de producción de la instalación que se proyecta a tres UAVs, producidos cada dos meses

  20. Diseño de un modelo para la optimización de los procesos en el mantenimiento programado aplicado al equipo Casa 212 de la Fuerza Aérea Colombiana

    José Enrique Sarmiento

    2006-01-01

    Full Text Available Este proyecto es el resultado de Ia busqueda constante de un mejoramiento continuo de los procesos que garantizan la calidad total en el mantenimiento aeronautico, concebdo y desarrollado para ser aplicado en el mantenimiento basico de 100 horas o 1A del equipo C-212-300 asignado al grupo técnico del Comando Aéreo de Combate No.2. Es así como se hace un recuento acerca de Ia historia y Ia evolución del mantenimiento aeronautico, Ia normatividad y los metodos de trabajo, el estudio de tiempos y movimientos empleados actualmente, para garantizar Ia eficiencia y seguridad en Ia aviación comercial y militar. De ahí, que se visitó la Base Aerea del Ejercito del Aire Español, SATENA y la Base Aerea de Apiay de Ia Fuerza Aerea Colombiana, quienes t ienen dentro de sus flotas el equipo C-212.

  1. Entrenamiento de la fuerza muscular como coadyuvante en la disminución del riesgo cardiovascular: una revisión sistemática Muscle strength training as co-adjuvant in cardiovascular risk reduction: a systematic review

    Isabel A Sánchez

    2009-12-01

    Full Text Available La fuerza muscular es una cualidad física importante dentro del desarrollo de las actividades básicas del ser humano, pese a que ha sido uno de los elementos poco trabajados dentro de la población con riesgo cardiovascular, debido a que no se poseen conceptos claros que hagan referencia a los efectos fisiológicos que se obtienen, los cuales siempre han sido motivo de discusión y de diferentes posturas para muchos investigadores. El objetivo de este artículo es mostrar con claridad los efectos fisiológicos que se logran con el entrenamiento de la fuerza, a través de una revisión sistemática. Para ello se tuvieron en cuenta 54 artículos de diferentes bases de datos, con el fin de contemplar las distintas conceptualizaciones realizadas por aquellos autores que se han dedicado al estudio de esta cualidad física. Estos autores tuvieron en cuenta aspectos tales como el entrenamiento de la fuerza muscular y los beneficios que se obtienen tras el entrenamiento de la misma, haciendo especial énfasis en lo referente al sistema cardiovascular desde el punto de vista hemodinámico, a nivel del sistema metabólico. Así, analizaron variables tales como ritmo metabólico y sensibilidad a la insulina y perfil lipídico, a fin de dar a conocer los fundamentos fisiológicos que faciliten posteriormente emplearlas como herramienta que favorezca no sólo el retorno a la funcionalidad del individuo, sino que, de manera concomitante, permitan disminuir aquellos índices generadores de patologías que se consideran como desencadenantes de riesgos cardiovasculares, de forma potencial en la población con riesgo cardiovascular. Concluyen que para que la información sea más representativa, es importante incentivar a los investigadores en la realización de más estudios aplicativos, que permitan demostrar que el entrenamiento de la fuerza muscular logra contribuir a la reducción de factores de riesgo cardiovascular aunque de una forma más lenta que el

  2. ESTUDIO PRELIMINAR DE LA RESISTENCIA MECÁNICA A LA FRACTURA Y FUERZA DE FIRMEZA PARA FRUTA DE UCHUVA (Physalis peruviana L. PRELIMINARY STUDY OF MECHANICAL RESISTANCE TO FRACTURE AND FIRMNESS FORCE FOR UCHUVA (Physalis peruviana L FRUITS

    Héctor José Ciro Velasquez

    2007-06-01

    Full Text Available Se hizo la caracterización reológica de la uchuva (Physalis peruviana L. a través de la respuesta mecánica bajo ensayos de compresión unidireccional a pruebas de firmeza y fractura, para 3 grados de madurez (verde, pintón y maduro y los días transcurridos después de la cosecha (1, 3, 5, 7, 9 días. Los resultados indicaron que la fuerza de firmeza y la resistencia mecánica a la fractura en dos sentidos de carga longitudinal y transversal disminuyen con el tiempo de poscosecha de la fruta, indicando que el fruto maduro es mas susceptible al daño mecánico con respecto al verde y pintón.A rheological characterization under unidirectional compression of uchuva fruits (Physalis peruviana L. was undertaken measuring the flesh firmness force and the fracture force according to three specifc developmental stages unripe, ripenning, ripe and five postharvest times (1,3,5,7 and 9 days. The results showed that the flesh firmness and the mechanical resistance to the fracture in two loading directions longitudinal and transversal diminish with the postharvest time. Moreover, the ripe fruit is more susceptible to mechanical damage with respect to unripe and ripening fruit.

  3. Propuesta de ejercicios para desarrollar la fuerza en los practicantes de 20 - 30 años de edad, sexo femenino que asisten al área de mecánicos del gimnasio de cultura física Fidel Linares Rodríguez del municipio Pinar del Río

    Yariel González Galván

    2009-06-01

    Full Text Available El presente trabajo parte de la necesidad de elaborar una propuesta de ejercicios para desarrollar la fuerza en los practicantes de 20-30 años de edad, sexo femenino que asiste al área de mecánicos del Gimnasio de Cultura Física Fidel Linares Rodríguez del municipio Pinar del Río. Los resultados expuestos en esta investigación se obtuvieron a través de la aplicación de diferentes métodos investigativos que permitieron realizar la propuesta ya mencionada. Su estructura cuenta con: Introducción, dos Capítulos, Conclusiones, Recomendaciones, Bibliografía y Anexos. El capítulo I, versa sobre la génesis y presupuestos teóricos de la fuerza y de los métodos para su desarrollo. El segundo, es la propuesta de ejercicios para el desarrollo de la fuerza, así como su correspondiente fundamentación y orientaciones metodológicas para su aplicación. Se arriba a conclusiones de gran valor para el trabajo con mujeres, en el área de mecánicos del Gimnasio Fidel Linares Rodríguez del municipio Pinar del Río

  4. Chemokine-Like Receptor 1 mRNA Weakly Correlates with Non-Alcoholic Steatohepatitis Score in Male but Not Female Individuals

    Maximilian Neumann

    2016-08-01

    Full Text Available The chemokine-like receptor 1 (CMKLR1 ligands resolvin E1 and chemerin are known to modulate inflammatory response. The progression of non-alcoholic fatty liver disease (NAFLD to non-alcoholic steatohepatitis (NASH is associated with inflammation. Here it was analyzed whether hepatic CMKLR1 expression is related to histological features of NASH. Therefore, CMKLR1 mRNA was quantified in liver tissue of 33 patients without NAFLD, 47 patients with borderline NASH and 38 patients with NASH. Hepatic CMKLR1 mRNA was not associated with gender and body mass index (BMI in the controls and the whole study group. CMKLR1 expression was similar in controls and in patients with borderline NASH and NASH. In male patients weak positive correlations with inflammation, fibrosis and NASH score were identified. In females CMKLR1 was not associated with features of NAFLD. Liver CMKLR1 mRNA tended to be higher in type 2 diabetes patients of both genders and in hypercholesterolemic women. In summary, this study shows that hepatic CMKLR1 mRNA is weakly associated with features of NASH in male patients only.

  5. Metabolic Thresholds and Validated Accelerometer Cutoff Points for the Actigraph GT1M in Young Children Based on Measurements of Locomotion and Play Activities

    Jimmy, Gerda; Dossegger, Alain; Seiler, Roland; Mader, Urs

    2012-01-01

    The purpose of the current study was to determine metabolic thresholds and subsequent activity intensity cutoff points for the ActiGraph GT1M with various epochs spanning from 5 to 60 sec in young children. Twenty-two children, aged 4 to 9 years, performed 10 different activities including locomotion and play activities. Energy expenditure was…

  6. The b-quark mass from non-perturbative $N_f=2$ Heavy Quark Effective Theory at $O(1/m_h)$

    Bernardoni, F.; Blossier, B.; Bulava, J.

    2014-01-01

    We report our final estimate of the b-quark mass from $N_f=2$ lattice QCD simulations using Heavy Quark Effective Theory non-perturbatively matched to QCD at $O(1/m_h)$. Treating systematic and statistical errors in a conservative manner, we obtain $\\overline{m}_{\\rm b}^{\\overline{\\rm MS}}(2 {\\rm...

  7. The computer code EURDYN - 1 M (release 1) for transient dynamic fluid-structure interaction. Pt.1: governing equations and finite element modelling

    Donea, J.; Fasoli-Stella, P.; Giuliani, S.; Halleux, J.P.; Jones, A.V.

    1980-01-01

    This report describes the governing equations and the finite element modelling used in the computer code EURDYN - 1 M. The code is a non-linear transient dynamic program for the analysis of coupled fluid-structure systems; It is designed for safety studies on LMFBR components (primary containment and fuel subassemblies)

  8. Effects of irradiation on TGF-β1 mRNA expression and calcific nodule formation in MC3T3-E1 osteoblastic cell line

    Song, Ju Seop; Kim, Kyoung A; Koh, Kwang Joon

    2008-01-01

    To investigate the effects of irradiation on transforming growth factor β1 (TGF-β 1 ) mRNA expression and calcific nodule formation in MC3T3-E1 osteoblastic cell line. Cells were cultured in alpha-minimum essential medium (α-MEM) supplemented with 10% fetal bovine serum and antibiotics. When the cells reached the level of 70-80% confluence, culture media were changed with α-MEM supplemented with 10% FBS, 5 mM β-glycerol phosphate, and 50 μg/mL ascorbic acid. Thereafter the cells were irradiated with a single dose of 2, 4, 6, 8 Gy at a dose rate of 1.5 Gy/min. The expression pattern of TGF-β 1 mRNA, calcium content and calcific nodule formation were examined on day 3, 7, 14, 21, 28, respectively, after the irradiation. The amount of TGF-β 1 mRNA expression decreased significantly on day 7 after irradiation of 4, 6, 8 Gy. It also decreased on day 14 after irradiation of 6, 8 Gy, and decreased on day 21 after irradiation of 8 Gy. The amount of calcium deposition decreased significantly on day 7 after irradiation of 4, 8 Gy (P 1 mRNA expression that was associated with proliferation and the production of extracellular matrix in MC3T3-E1 osteoblastic cell line

  9. A chopper current-feedback instrumentation amplifier with a 1 mHz 1/f noise corner and an AC-coupled ripple reduction loop

    Wu, R.; Makinwa, K.A.A.; Huijsing, J.H.

    2009-01-01

    This paper presents a chopper instrumentation amplifier for interfacing precision thermistor bridges. For high CMRR and DC gain, the amplifier employs a three-stage current-feedback topology with nested-Miller compensation. By chopping both the input and intermediate stages of the amplifier, a 1 mHz

  10. Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice.

    McLachlan, Stela; Page, Kathryn E; Lee, Seung-Min; Loguinov, Alex; Valore, Erika; Hui, Simon T; Jung, Grace; Zhou, Jie; Lusis, Aldons J; Fuqua, Brie; Ganz, Tomas; Nemeth, Elizabeta; Vulpe, Chris D

    2017-11-01

    Iron homeostasis is tightly regulated, and the peptide hormone hepcidin is considered to be a principal regulator of iron metabolism. Previous studies in a limited number of mouse strains found equivocal sex- and strain-dependent differences in mRNA and serum levels of hepcidin and reported conflicting data on the relationship between hepcidin ( Hamp1 ) mRNA levels and iron status. Our aim was to clarify the relationships between strain, sex, and hepcidin expression by examining multiple tissues and the effects of different dietary conditions in multiple inbred strains. Two studies were done: first, Hamp1 mRNA, liver iron, and plasma diferric transferrin levels were measured in 14 inbred strains on a control diet; and second, Hamp1 mRNA and plasma hepcidin levels in both sexes and iron levels in the heart, kidneys, liver, pancreas, and spleen in males were measured in nine inbred/recombinant inbred strains raised on an iron-sufficient or high-iron diet. Both sex and strain have a significant effect on both hepcidin mRNA (primarily a sex effect) and plasma hepcidin levels (primarily a strain effect). However, liver iron and diferric transferrin levels are not predictors of Hamp1 mRNA levels in mice fed iron-sufficient or high-iron diets, nor are the Hamp1 mRNA and plasma hepcidin levels good predictors of tissue iron levels, at least in males. We also measured plasma erythroferrone, performed RNA-sequencing analysis of liver samples from six inbred strains fed the iron-sufficient, low-iron, or high-iron diets, and explored differences in gene expression between the strains with the highest and lowest hepcidin levels. NEW & NOTEWORTHY Both sex and strain have a significant effect on both hepcidin mRNA (primarily a sex effect) and plasma hepcidin levels (primarily a strain effect). Liver iron and diferric transferrin levels are not predictors of Hamp1 mRNA levels in mice, nor are the Hamp1 mRNA and plasma hepcidin levels good predictors of tissue iron levels, at least

  11. Effects of muscarinic receptor antagonists on cocaine discrimination in wild-type mice and in muscarinic receptor M1, M2, and M4 receptor knockout mice.

    Joseph, Lauren; Thomsen, Morgane

    2017-06-30

    Muscarinic M 1 /M 4 receptor stimulation can reduce abuse-related effects of cocaine and may represent avenues for treating cocaine addiction. Muscarinic antagonists can mimic and enhance effects of cocaine, including discriminative stimulus (S D ) effects, but the receptor subtypes mediating those effects are not known. A better understanding of the complex cocaine/muscarinic interactions is needed to evaluate and develop potential muscarinic-based medications. Here, knockout mice lacking M 1 , M 2 , or M 4 receptors (M 1 -/- , M 2 -/- , M 4 -/- ), as well as control wild-type mice and outbred Swiss-Webster mice, were trained to discriminate 10mg/kg cocaine from saline. Muscarinic receptor antagonists with no subtype selectivity (scopolamine), or preferential affinity at the M 1 , M 2 , or M 4 subtype (telenzepine, trihexyphenidyl; methoctramine, AQ-RA 741; tropicamide) were tested alone and in combination with cocaine. In intact animals, antagonists with high affinity at M 1 /M 4 receptors partially substituted for cocaine and increased the S D effect of cocaine, while M 2 -preferring antagonists did not substitute, and reduced the S D effect of cocaine. The cocaine-like effects of scopolamine were absent in M 1 -/- mice. The cocaine S D attenuating effects of methoctramine were absent in M 2 -/- mice and almost absent in M 1 -/- mice. The findings indicate that the cocaine-like S D effects of muscarinic antagonists are primarily mediated through M 1 receptors, with a minor contribution of M 4 receptors. The data also support our previous findings that stimulation of M 1 receptors and M 4 receptors can each attenuate the S D effect of cocaine, and show that this can also be achieved by blocking M 2 autoreceptors, likely via increased acetylcholine release. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine.

    Seid, Christopher A; Curti, Elena; Jones, R Mark; Hudspeth, Elissa; Rezende, Wanderson; Pollet, Jeroen; Center, Lori; Versteeg, Leroy; Pritchard, Sonya; Musiychuk, Konstantin; Yusibov, Vidadi; Hotez, Peter J; Bottazzi, Maria Elena

    2015-01-01

    Over 400 million people living in the world's poorest developing nations are infected with hookworms, mostly of the genus Necator americanus. A bivalent human hookworm vaccine composed of the Necator americanus Glutathione S-Transferase-1 (Na-GST-1) and the Necator americanus Aspartic Protease-1 (Na-APR-1 (M74)) is currently under development by the Sabin Vaccine Institute Product Development Partnership (Sabin PDP). Both monovalent vaccines are currently in Phase 1 trials. Both Na-GST-1 and Na-APR-1 antigens are expressed as recombinant proteins. While Na-GST-1 was found to express with high yields in Pichia pastoris, the level of expression of Na-APR-1 in this host was too low to be suitable for a manufacturing process. When the tobacco plant Nicotiana benthamiana was evaluated as an expression system, acceptable levels of solubility, yield, and stability were attained. Observed expression levels of Na-APR-1 (M74) using this system are ∼300 mg/kg. Here we describe the achievements and obstacles encountered during process development as well as characterization and stability of the purified Na-APR-1 (M74) protein and formulated vaccine. The expression, purification and analysis of purified Na-APR-1 (M74) protein obtained from representative 5 kg reproducibility runs performed to qualify the Na-APR-1 (M74) production process is also presented. This process has been successfully transferred to a pilot plant and a 50 kg scale manufacturing campaign under current Good Manufacturing Practice (cGMP) has been performed. The 50 kg run has provided a sufficient amount of protein to support the ongoing hookworm vaccine development program of the Sabin PDP.

  13. Reexamination of M2,3 atomic level widths and L1M2,3 transition energies of elements 69≤Z≤95

    Fennane, K.; Berset, M.; Dousse, J.-Cl.; Hoszowska, J.; Raboud, P.-A.; Campbell, J. L.

    2013-11-01

    We report on high-resolution measurements of the photoinduced L1M2 and L1M3 x-ray emission lines of 69Tm, 70Yb, 71Lu, 73Ta, 74W, 75Re, 77Ir, 81Tl, 83Bi, and 95Am. From the linewidths of the measured transitions an accurate set of M2 and M3 level widths is determined assuming for the L1 level widths the values reported by Raboud [P.-A. Raboud et al., Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.65.022512 65, 022512 (2002)]. Furthermore, the present experimental M2,3 data set is extended to 80Hg, 90Th, and 92U, using former L1M2,3 high-resolution x-ray emission spectroscopy measurements performed by our group. A detailed comparison of the M2 and M3 level widths determined in the present work with those recommended by Campbell and Papp [J. L. Campbell and T. Papp, At. Data Nucl. Data TablesADNDAT0092-640X10.1006/adnd.2000.0848 77, 1 (2001)] and other available experimental data as well as theoretical predictions is done. The observed abrupt changes of the M2,3 level widths versus atomic number Z can be explained satisfactorily by the cutoffs and onsets of the M2M4N1, respectively M3M4N3,4,5 and M3M5N2,3 Coster-Kronig transitions deduced from the semiempirical (Z+1) approximation. As a spin-off result of this study, precise L1M2 and L1M3 transition energies are obtained for the investigated elements. A very good agreement with transition energies calculated within the many-body perturbation theory is found.

  14. β-glucuronidase use as a single internal control gene may confound analysis in FMR1 mRNA toxicity studies.

    Kraan, Claudine M; Cornish, Kim M; Bui, Quang M; Li, Xin; Slater, Howard R; Godler, David E

    2018-01-01

    Relationships between Fragile X Mental Retardation 1 (FMR1) mRNA levels in blood and intragenic FMR1 CGG triplet expansions support the pathogenic role of RNA gain of function toxicity in premutation (PM: 55-199 CGGs) related disorders. Real-time PCR (RT-PCR) studies reporting these findings normalised FMR1 mRNA level to a single internal control gene called β-glucuronidase (GUS). This study evaluated FMR1 mRNA-CGG correlations in 33 PM and 33 age- and IQ-matched control females using three normalisation strategies in peripheral blood mononuclear cells (PBMCs): (i) GUS as a single internal control; (ii) the mean of GUS, Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) and succinate dehydrogenase complex flavoprotein subunit A (SDHA); and (iii) the mean of EIF4A2 and SDHA (with no contribution from GUS). GUS mRNA levels normalised to the mean of EIF4A2 and SDHA mRNA levels and EIF4A2/SDHA ratio were also evaluated. FMR1mRNA level normalised to the mean of EIF4A2 and SDHA mRNA levels, with no contribution from GUS, showed the most significant correlation with CGG size and the greatest difference between PM and control groups (p = 10-11). Only 15% of FMR1 mRNA PM results exceeded the maximum control value when normalised to GUS, compared with over 42% when normalised to the mean of EIF4A2 and SDHA mRNA levels. Neither GUS mRNA level normalised to the mean RNA levels of EIF4A2 and SDHA, nor to the EIF4A2/SDHA ratio were correlated with CGG size. However, greater variability in GUS mRNA levels were observed for both PM and control females across the full range of CGG repeat as compared to the EIF4A2/SDHA ratio. In conclusion, normalisation with multiple control genes, excluding GUS, can improve assessment of the biological significance of FMR1 mRNA-CGG size relationships.

  15. Evaluation of folate receptor 1 (FOLR1) mRNA expression, its specific promoter methylation and global DNA hypomethylation in type I and type II ovarian cancers

    Notaro, Sara; Reimer, Daniel; Fiegl, Heidi; Schmid, Gabriel; Wiedemair, Annamarie; Rössler, Julia; Marth, Christian; Zeimet, Alain Gustave

    2016-01-01

    In this retrospective study we evaluated the respective correlations and clinical relevance of FOLR1 mRNA expression, FOLR1 promoter specific methylation and global DNA hypomethylation in type I and type II ovarian cancer. Two hundred fifty four ovarian cancers, 13 borderline tumours and 60 samples of healthy fallopian epithelium and normal ovarian epithelium were retrospectively analysed for FOLR1 expression with RT-PCR. FOLR1 DNA promoter methylation and global DNA hypomethylation (measured by means of LINE1 DNA hypomethylation) were evaluated with MethyLight technique. No correlation between FOLR1 mRNA expression and its specific promoter DNA methylation was found neither in type I nor in type II cancers, however, high FOLR1 mRNA expression was found to be correlated with global DNA hypomethylation in type II cancers (p = 0.033). Strong FOLR1 mRNA expression was revealed for Grades 2-3, FIGO stages III-IV, residual disease > 0, and serous histotype. High FOLR1 expression was found to predict increased platinum sensitivity in type I cancers (odds ratio = 3.288; 1.256-10.75; p = 0.020). One-year survival analysis showed in type I cancers an independent better outcome for strong expression of FOLR1 in FIGO stage III and IV. For the entire follow up period no significant independent outcome for FOLR1 expression was revealed. In type I cancers LINE 1 DNA hypomethylation was found to exhibit a worse PFS and OS which were confirmed to be independent in multivariate COX regression model for both PFS (p = 0.026) and OS (p = 0.012). No correlations were found between FOLR1 expression and its specific promoter methylation, however, high FOLR1 mRNA expression was associated with DNA hypomethylation in type II cancers. FOLR1 mRNA expression did not prove to predict clinical outcome in type II cancers, although strong FOLR1 expression generally denotes ovarian cancers with highly aggressive phenotype. In type I cancers, however, strong FOLR1 expression has been found to be a

  16. MODIFICACIONES DE LA CAPACIDAD DE SALTO EN LAS PRUEBAS DEL TEST DE BOSCO TRAS LA APLICACIÓN DE UN ENTRENAMIENTO DE FUERZA BASADO EN EL MÉTODO DE CONTRASTE ENTRE SUJETOS DE 50 A 70 AÑOS CON DIFERENTES NIVELES DE ACTIVIDAD FÍSICA

    J.M. González

    2010-09-01

    Full Text Available

     

    RESUMEN

    El objetivo de este estudio fue el análisis de las modificaciones producidas en la capacidad de salto de los miembros inferiores, tras un programa de entrenamiento de fuerza realizado a través del uso de la combinación de cargas pesadas y ligeras durante 16 semanas medidas a través del test de Bosco: SJ, CMJ y DJ. 23 sujetos, 13 hombres y 10 mujeres divididos en dos grupos: deportistas(GD y físicamente activos(GND se sometieron al programa de entrenamiento. El instrumental utilizado para la medición fue la plataforma de presión (licencia Fac. Ciencias Activ. Física y Deporte Univ. Granada Se realizó un diseño experimental con un diseño de medida pretratamiento, aplicación de un tratamiento y medida post-tratamiento a dos grupos diferentes. Los resultados muestran que la fuerza explosiva, la elástico-explosiva, la explosivo-elástico-reactiva y la resistencia de fuerza rápida medidas indirectamente a través de la altura de salto son mayores en sujetos deportistas respecto a sujetos físicamente activos antes del entrenamiento de fuerza. La aplicación de un entrenamiento de fuerza basado en el método de contraste en la sesión durante 16 semanas ha mejorado significativamente en las extremidades inferiores las diferentes manifestaciones de fuerza previamente referidas en el GND y en el GD.
    PALABRAS CLAVE: entrenamiento, contraste, mayores, fuerza.

    ABSTRACT

    The aim of this study is to examine the differences of force production in 50 -70 year old athletes and active subjects, both before and after the strength training and, on the other hand the effects of such a 16 week strength training on height jump in bosco protocol (SJ, CMJ, DJ. The strength training is based on the alternative use of light and heavy leads

  17. Preparation of chromatographically pure specimens, crystallization, and X-ray diffraction study of the periplasmatic chaperone protein Caf1M from Y. Pestis

    Mikhailov, A.M.; Vainshtein, B.K.; Chernovskaya, T.V.; Vasil'ev, A.M.; Rudenko, E.G.; Abramov, V.M.; Zav'yalov, V.P.; Kornev, A.N.; Kornilov, V.V.; Karlyshev, A.V.; MacIntyre, Sh.

    1999-01-01

    The for growing conditions perfect single crystals of the protein Caf1M have been established. The unit-cell parameters of the crystals are (a=112.6 A, b=78.1 A, c=65.3 A, sp. gr. P2 1 2 1 2 1 ), molecular weight is 28 kDa), which is a representative of molecular periplasmatic chaperones, were found. This investigation is the first necessary stage of determination the three-dimensional structure of this biomacromolecule at atomic resolution. Taking into account that the primary amino acid sequences of the protein Caf1M and of the structurally studied protein PapD and also their secondary structures are homologous, the phase problem can be solved by the molecular replacement method

  18. The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals

    Vogel, Lotte K; Saebø, Mona; Skjelbred, Camilla F

    2006-01-01

    .001) and severe (p ratio than corresponding normal tissue from healthy control individuals (p ... that the ratio of matriptase to HAI-1 influences the malignant progression. The aim of this study has been to determine the ratio of matriptase to HAI-1 mRNA expression in affected and normal tissue from individuals with colorectal cancer adenomas and carcinomas as well as in healthy individuals, in order...... to determine at which stages a dysregulated ratio of matriptase/HAI-1 mRNA is present during carcinogenesis. METHODS: Using quantitative RT-PCR, we have determined the mRNA levels for matriptase and HAI-1 in colorectal cancer tissue (n = 9), severe dysplasia (n = 15), mild/moderate dysplasia (n = 21...

  19. Matching of heavy-light flavour currents between HQET at order 1/m and QCD. I. Strategy and tree-level study

    Della Morte, Michele [Instituto de Fisica Corpuscular IFIC (CSIC), Paterna (Spain); Dooling, Samantha; Heitger, Jochen [Muenster Univ. (Germany). Inst. fuer Theoretische Physik 1; Hesse, Dirk [Parma Univ. degli Studi (Italy); Simma, Hubert [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Collaboration: ALPHA Collaboration

    2013-12-15

    We present a strategy how to match the full set of components of the heavy-light axial and vector currents in Heavy Quark Effective Theory (HQET), up to and including 1/m{sub h}-corrections, to QCD. While the ultimate goal is to apply these matching conditions non-perturbatively, in this study we first have implemented them at tree-level, in order to find good choices of the matching observables with small O(1/m{sup 2}{sub h}) contributions. They can later be employed in the non-perturbative matching procedure which is a crucial part of precision HQET computations of semileptonic decay form factors in lattice QCD.

  20. Influence of the nature of conductive support on the electrocatalytic activity of electrodeposited Ni films towards methanol oxidation in 1 M KOH

    Singh, R.N.; Singh, A.; Anindita; Mishra, D. [Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005 (India)

    2008-12-15

    The study of electrochemical behaviour of dispersed Ni on graphite, glassy carbon, and Ti electrodes, obtained by an electro-deposition method, is carried out in 1 M KOH + 1 M CH{sub 3}OH at 25 C. Results show that the nature of substrate influences the apparent electrocatalytic activities of the Ni over layer greatly. It is observed that at E = 0.50 V vs. Hg/HgO (25 C), the dispersed Ni on graphite is approx. 300 times more active than that dispersed on Ti and is approx. 260 times more active than that dispersed on glassy carbon. Further, these electrodes show quite good resistance against electrode poisoning by the methanol oxidation intermediates/products. (author)

  1. K1M4 METAR

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  2. An ultrathin polymer coating of carboxylate self-assembled monolayer adsorbed on passivated iron to prevent iron corrosion in 0.1 M Na2SO4

    Aramaki, Kunitsugu; Shimura, Tadashi

    2010-01-01

    For preparing an ultrathin two-dimensional polymer coating adsorbed on passivated iron, a 16-hydroxyhexadecanoate ion HO(CH 2 ) 15 CO 2 - self-assembled monolayer (SAM) was modified with 1,2-bis(triethoxysilyl)ethane (C 2 H 5 O) 3 Si(CH 2 ) 2 Si(OC 2 H 5 ) 3 and octadecyltriethoxysilane C 18 H 37 Si(OC 2 H 5 ) 3 . Protection of passivated iron against passive film breakdown and corrosion of iron was investigated by monitoring of the open-circuit potential and repeated polarization measurements in an aerated 0.1 M Na 2 SO 4 solution during immersion for many hours. The time required for passive film breakdown of the polymer-coated electrode was markedly higher in this solution than that of the passivated one, indicating protection of the passive film from breakdown by coverage with the polymer coating. The protective efficiencies of the passive film covered with the coating were extremely high, more than 99.9% in 0.1 M Na 2 SO 4 before the passive film was broken down, showing prominent cooperative suppression of iron corrosion in the solution by coverage with the passive film and polymer coating. The polymer-coated surface was characterized by contact angle measurement and electron-probe microanalysis (EPMA). Prevention of passive film breakdown and iron corrosion for the polymer-coated electrode healed in 0.1 M NaNO 3 was also examined in 0.1 M Na 2 SO 4 .

  3. Polarographic study of the Cu(II)/Cu(I) system in the presence of 1-ascorbic acid and 0,1 M ClK

    Alonso Lopez, J.

    1969-01-01

    While studying the catalytic effect of Cu ↓ 2 ions on the oxidation process of 1-ascorbic acid, it has been observed that, in a 0,1 M solution of K1 at a pH 6 to 7, the above acid gives rise in the presence of Cu ↓ 2 ions to a polarographic wave of half-wave potential of -0,41 V (vs. S.C.E.). (Author) 14 refs

  4. Alkaloids extract of Retama monosperma (L.) Boiss. seeds used as novel eco-friendly inhibitor for carbon steel corrosion in 1 M HCl solution: Electrochemical and surface studies

    El Hamdani, Naoual; Fdil, Rabiaa [Laboratoire de Chimie Bioorganique, Faculté des Sciences, Université Chouaib Doukkali, B.P. 20, M-24000 El Jadida (Morocco); Tourabi, Mustapha [Laboratoire de Catalyse et de Corrosion des Matériaux (LCCM), Faculté des Sciences, Université Chouaib Doukkali, B.P. 20, M-24000 El Jadida (Morocco); Jama, Charafeddine [UMET-PSI, CNRS UMR 8207, ENSCL, Université Lille 1, CS 90108, F-59652 Villeneuve d’Ascq Cedex (France); Bentiss, Fouad, E-mail: fbentiss@enscl.fr [Laboratoire de Catalyse et de Corrosion des Matériaux (LCCM), Faculté des Sciences, Université Chouaib Doukkali, B.P. 20, M-24000 El Jadida (Morocco); UMET-PSI, CNRS UMR 8207, ENSCL, Université Lille 1, CS 90108, F-59652 Villeneuve d’Ascq Cedex (France)

    2015-12-01

    Graphical abstract: - Highlights: • AERS is good eco-friendly corrosion inhibitor for carbon steel in 1 M HCl. • AERS acts as mixed-type inhibitor in 1 M HCl medium. • AERS adsorption is well described by Langmuir isotherm. • Surface analyses were used to explain the AERS mechanism of carbon steel corrosion inhibition. - Abstract: Current research efforts now focus on the development of non-toxic, inexpensive and environmentally friendly corrosion inhibitors as alternatives to different organic and non-organic compounds. In this field, alkaloids extract of Retama monosperma (L.) Boiss. seeds (AERS) was tested for the first time as corrosion inhibitor for carbon steel in 1 M HCl medium using electrochemical and surface characterization techniques. The obtained results showed that this plant extract's acts as an efficient corrosion inhibitor for carbon steel in 1 M HCl and an inhibition efficiency of 94.4% was reached with 400 mg/L of AERS at 30 °C. Ac impedance experimental data revealed a frequency distribution of the capacitance, simulated as constant phase element. Impedance results demonstrated that the addition of the AERS in the corrosive solution decreases the charge capacitance and simultaneously increases the function of the charge/discharge of the interface, facilitating the formation of an adsorbed layer over the steel surface. Polarization curves indicated that AERS is a mixed inhibitor. Adsorption of such alkaloid extract on the steel surface obeyed to the Langmuir adsorption isotherm. X-ray photoelectron spectroscopy (XPS) showed that the inhibition of steel corrosion in normal hydrochloric solution by AERS is mainly controlled by a physisorption process and the inhibitive layer is composed of an iron oxide/hydroxide mixture where AERS molecules are incorporated.

  5. Flow distribution experimental study on the emergency core cooling system of the IEA-R1m - IPEN-CNEN/SP - Brazil

    Torres, Walmir Maximo; Baptista Filho, Benedito Dias; Ting, Daniel Kao Sun

    1999-01-01

    This paper presents a brief description of Emergency Core Cooling System designed by the IEA-R1m Reactor and the experimental results of flow distribution over the core. Several parameters were evaluated, such as: relative position of spray header to the reactor core; type and quantity of spray nozzles; spray nozzles position on spray header; and total spray flow. The main conclusions are presented. (author)

  6. PAI-1 mRNA expression and plasma level in rheumatoid arthritis: relationship with 4G/5G PAI-1 polymorphism.

    Muñoz-Valle, José Francisco; Ruiz-Quezada, Sandra Luz; Oregón-Romero, Edith; Navarro-Hernández, Rosa Elena; Castañeda-Saucedo, Eduardo; De la Cruz-Mosso, Ulises; Illades-Aguiar, Berenice; Leyva-Vázquez, Marco Antonio; Castro-Alarcón, Natividad; Parra-Rojas, Isela

    2012-12-01

    Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the synovial membrane, cartilage and bone. PAI-1 is a key regulator of the fibrinolytic system through which plasminogen is converted to plasmin. The plasmin activates the matrix metalloproteinase system, which is closely related with the joint damage and bone destruction in RA. The aim of this study was to investigate the relationship between 4G/5G PAI-1 polymorphism with mRNA expression and PAI-1 plasma protein levels in RA patients. 113 RA patients and 123 healthy subjects (HS) were included in the study. The 4G/5G PAI-1 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism method; the PAI-1 mRNA expression was determined by real-time PCR; and the soluble PAI-1 (sPAI-1) levels were quantified using an ELISA kit. No significant differences in the genotype and allele frequencies of 4G/5G PAI-1 polymorphism were found between RA patients and HS. However, the 5G/5G genotype was the most frequent in both studied groups: RA (42%) and HS (44%). PAI-1 mRNA expression was slightly increased (0.67 fold) in RA patients with respect to HS (P = 0.0001). In addition, in RA patients, the 4G/4G genotype carriers showed increased PAI-1 mRNA expression (3.82 fold) versus 4G/5G and 5G/5G genotypes (P = 0.0001), whereas the sPAI-1 plasma levels did not show significant differences. Our results indicate that the 4G/5G PAI-1 polymorphism is not a marker of susceptibility in the Western Mexico. However, the 4G/4G genotype is associated with high PAI-1 mRNA expression but not with the sPAI-1 levels in RA patients.

  7. One-loop corrections of orders (Zα)6m1/m2 and (Zα)7 to the fine structure of muonium

    Martynenko, A.P.; Faustov, R.N.

    2003-01-01

    Corrections of orders (Zα) 6 m 1 /m 2 and (Zα) 7 from one-loop two-photon amplitudes to the energy spectra of hydrogen-like atoms are calculated by expanding the relevant integrand in a Taylor series. A method for averaging the resulting quasipotential in the d-dimensional coordinate representation is formulated. Numerical values are obtained for the corresponding contributions to the fine structure of the muonium, hydrogen, and positronium atoms

  8. Benefit of adjuvant chemotherapy after resection of stage II (T1-2N1M0) non-small cell lung cancer in elderly patients.

    Berry, Mark F; Coleman, Brooke K; Curtis, Lesley H; Worni, Mathias; D'Amico, Thomas A; Akushevich, Igor

    2015-02-01

    We evaluated the use and efficacy of adjuvant chemotherapy after resection of T1-2N1M0 non-small cell lung cancer (NSCLC) in elderly patients. Factors associated with the use of adjuvant chemotherapy in patients older than 65 years of age who underwent surgical resection of T1-2N1M0 NSCLC without induction chemotherapy or radiation in the Surveillance, Epidemiology, and End Results-Medicare database from 1992 to 2006 were assessed using a multivariable logistic regression model that included treatment, patient, tumor, and census tract characteristics. Overall survival (OS) was analyzed using the Kaplan-Meier approach and inverse probability weight-adjusted Cox proportional hazard models. Overall, 2,781 patients who underwent surgical resection as the initial treatment for T1-2N1M0 NSCLC and survived at least 31 days after surgery were identified, with adjuvant chemotherapy given to 784 patients (28.2 %). Factors that predicted adjuvant chemotherapy use were younger age and higher T status. The 5-year OS was significantly better for patients who received adjuvant chemotherapy compared with patients not given adjuvant chemotherapy: 35.8 % (95 % confidence interval [CI] 31.9-39.6) vs. 28.0 % (95 % CI 25.9-30.0) (p = 0.008). In the inverse probability weight-adjusted Cox proportional hazard regression model, adjuvant chemotherapy use predicted significantly improved survival (hazard ratio 0.84; 95 % CI 0.76-0.92; p = 0.0002). Adjuvant chemotherapy after resection of T1-2N1M0 NSCLC is associated with significantly improved survival in patients older than 65 years. These data can be used to provide elderly patients with realistic expectations of the potential benefits when considering adjuvant chemotherapy in this setting.

  9. Autoradiography of H-3-pirenzepine and H-3-AFDX-384 in Mouse Brain Regions: Possible Insights into M-1, M-2, and M-4 Muscarinic Receptors Distribution

    Valuskova, P.; Farar, V.; Forczek, Sándor; Křížová, I.; Mysliveček, J.

    2018-01-01

    Roč. 9, FEB 20 (2018), č. článku 124. ISSN 1663-9812 Institutional support: RVO:61389030 Keywords : 3 h-afdx-384 * 3 H-pirenzepine * 3 h-qnb * Autoradiography * M muscarinic receptor 1 * M muscarinic receptor 2 * M muscarinic receptor 4 Subject RIV: FH - Neurology OBOR OECD: Neurosciences (including psychophysiology Impact factor: 4.400, year: 2016

  10. Classification of acute myeloid leukemia subtypes M1, M2 and M3 using active contour without edge segmentation and momentum backpropagation artificial neural network

    Harjoko Agus

    2018-01-01

    Full Text Available Acute Myeloid Leukemia (AML is a type of cancer which attacks white blood cells from myeloid. AML has eight subtypes, namely: M0, M1, M2, M3, M4, M5, M6, and M7. AML subtypes M1, M2 and M3 are affected by the same type of cells, myeloblast, making it needs more detailed analysis to distinguish. To overcome these obstacles, this research is applying digital image processing with Active Contour Without Edge (ACWE and Momentum Backpropagation artificial neural network for AML subtypes M1, M2 and M3 classification based on the type of the cell. Six features required as training parameters from every cell obtained by using feature extraction. The features are: cell area, perimeter, circularity, nucleus ratio, mean and standard deviation. The results show that ACWE can be used for segmenting white blood cells with 83.789% success percentage of 876 total cell objects. The whole AML slides had been identified according to the cell types predicted number through training with momentum backpropagation. Five times testing calibration with the best parameter generated averages value of 84.754% precision, 75.887% sensitivity, 95.090% specificity and 93.569% accuracy.

  11. Ten minutes of 1 mA transcranial direct current stimulation was well tolerated by children and adolescents: Self-reports and resting state EEG analysis.

    Moliadze, Vera; Andreas, Saskia; Lyzhko, Ekaterina; Schmanke, Till; Gurashvili, Tea; Freitag, Christine M; Siniatchkin, Michael

    2015-10-01

    Transcranial direct current stimulation (tDCS) is a promising and well-tolerated method of non-invasive brain stimulation, by which cortical excitability can be modulated. However, the effects of tDCS on the developing brain are still unknown, and knowledge about its tolerability in children and adolescents is still lacking. Safety and tolerability of tDCS was assessed in children and adolescents by self-reports and spectral characteristics of electroencephalogram (EEG) recordings. Nineteen typically developing children and adolescents aged 11-16 years participated in the study. Anodal and cathodal tDCS as well as sham stimulation were applied for a duration of 10 min over the left primary motor cortex (M1), each with an intensity of 1 mA. Subjects were unable to identify whether they had received active or sham stimulation, and all participants tolerated the stimulation well with a low rate of adverse events in both groups and no serious adverse events. No pathological oscillations, in particular, no markers of epileptiform activity after 1mA tDCS were detected in any of the EEG analyses. In summary, our study demonstrates that tDCS with 1mA intensity over 10 min is well tolerated, and thus may be used as an experimental and treatment method in the pediatric population. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

    Ri, M; Tashiro, E; Oikawa, D; Shinjo, S; Tokuda, M; Yokouchi, Y; Narita, T; Masaki, A; Ito, A; Ding, J; Kusumoto, S; Ishida, T; Komatsu, H; Shiotsu, Y; Ueda, R; Iwawaki, T; Imoto, M; Iida, S

    2012-01-01

    The IRE1α-XBP1 pathway, a key component of the endoplasmic reticulum (ER) stress response, is considered to be a critical regulator for survival of multiple myeloma (MM) cells. Therefore, the availability of small-molecule inhibitors targeting this pathway would offer a new chemotherapeutic strategy for MM. Here, we screened small-molecule inhibitors of ER stress-induced XBP1 activation, and identified toyocamycin from a culture broth of an Actinomycete strain. Toyocamycin was shown to suppress thapsigargin-, tunicamycin- and 2-deoxyglucose-induced XBP1 mRNA splicing in HeLa cells without affecting activating transcription factor 6 (ATF6) and PKR-like ER kinase (PERK) activation. Furthermore, although toyocamycin was unable to inhibit IRE1α phosphorylation, it prevented IRE1α-induced XBP1 mRNA cleavage in vitro. Thus, toyocamycin is an inhibitor of IRE1α-induced XBP1 mRNA cleavage. Toyocamycin inhibited not only ER stress-induced but also constitutive activation of XBP1 expression in MM lines as well as primary samples from patients. It showed synergistic effects with bortezomib, and induced apoptosis of MM cells including bortezomib-resistant cells at nanomolar levels in a dose-dependent manner. It also inhibited growth of xenografts in an in vivo model of human MM. Taken together, our results suggest toyocamycin as a lead compound for developing anti-MM therapy and XBP1 as an appropriate molecular target for anti-MM therapy

  13. Multiparameter imaging of calcium and abscisic acid and high-resolution quantitative calcium measurements using R-GECO1-mTurquoise in Arabidopsis.

    Waadt, Rainer; Krebs, Melanie; Kudla, Jörg; Schumacher, Karin

    2017-10-01

    Calcium signals occur in specific spatio-temporal patterns in response to various stimuli and are coordinated with, for example, hormonal signals, for physiological and developmental adaptations. Quantification of calcium together with other signalling molecules is required for correlative analyses and to decipher downstream calcium-decoding mechanisms. Simultaneous in vivo imaging of calcium and abscisic acid has been performed here to investigate the interdependence of the respective signalling processes in Arabidopsis thaliana roots. Advanced ratiometric genetically encoded calcium indicators have been generated and in vivo calcium calibration protocols were established to determine absolute calcium concentration changes in response to auxin and ATP. In roots, abscisic acid induced long-term basal calcium concentration increases, while auxin triggered rapid signals in the elongation zone. The advanced ratiometric calcium indicator R-GECO1-mTurquoise exhibited an increased calcium signal resolution compared to commonly used Förster resonance energy transfer-based indicators. Quantitative calcium measurements in Arabidopsis root tips using R-GECO1-mTurquoise revealed detailed maps of absolute calcium concentration changes in response to auxin and ATP. Calcium calibration protocols using R-GECO1-mTurquoise enabled high-resolution quantitative imaging of resting cytosolic calcium concentrations and their dynamic changes that revealed distinct hormonal and ATP responses in roots. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  14. Acute and chronic effects of exposure to a 1-mT magnetic field on the cytoskeleton, stress proteins, and proliferation of astroglial cells in culture

    Bodega, G.; Forcada, I.; Suarez, I.; Fernandez, B.

    2005-01-01

    This paper reports the effects of exposure to static, sinusoidal (50 Hz), and combined static/sinusoidal magnetic fields on cultured astroglial cells. Confluent primary cultures of astroglial cells were exposed to a 1-mT sinusoidal, static, or combined magnetic field for 1 h. In another experiment, cells were exposed to the combined magnetic field for 1, 2, and 4 h. The hsp25, hsp60, hsp70, actin, and glial fibrillary acidic protein contents of the astroglial cells were determined by immunoblotting 24 h after exposure. No significant differences were seen between control and exposed cells with respect to their contents of these proteins, neither were any changes in cell morphology observed. In a third experiment to determine the effect of a chronic (11-day) exposure to a combined 1-mT static/sinusoidal magnetic field on the proliferation of cultured astroglial cells, no significant differences were seen between control, sham-exposed, or exposed cells. These results suggest that exposure to 1-mT sinusoidal, static, or combined magnetic fields has no significant effects on the stress, cytoskeletal protein levels in, or proliferation of cultured astroglial cells

  15. Evaluación electromiográfica de los músculos masticadores durante la fuerza máxima de mordedura Electromyography evaluations of the masticator muscles during the maximum bite force

    M.J.P. Coelho-Ferraz

    2008-12-01

    Full Text Available La actividad de los músculos masetero y de la porción anterior temporal de ambos lados, derecho e izquierdo, respectivamente, durante la fuerza máxima de mordedura fue estudiada en voluntarios sanos. El estudio incluyó a 17 voluntarios adultos de ambos sexos, edad promedia de 25 años, que no evidenciaban ningún indicio de disfunción temporomandibular y eran relacionados con la Facultad de Odontología de Piracicaba. Se registraron los datos electromiográficos en ambos lados de la cara del masetero y de la porción anterior de los músculos temporal y suprahioideo en las posiciones postural e isométrica. Se utilizaron electrodos de superficie pasivos para niños, de Ag/AgCl, con forma circular y descargables de Meditrace® Kendall-LTP, modelo Chicopee MA01. Éstos se conectaron a un preamplificador con una ganancia de 20x que formaba un circuito de diferenciales. Se captaron los registros de las señales eléctricas utilizando un equipo EMG-8OOC de EMG System of Brazil, Ltd., de ocho canales, a una frecuencia de 2 KHz con 16 bitios de resolución y un filtro digital con un paso de banda de 20 a 500 Hz. Se utilizó también un transductor de presión que consistía en un tubo de goma con un sensor de presión (MPX 5700* (Motorola SPS, Austin, TX, EE.UU. para registrar la fuerza máxima de mordedura. El análisis estadístico incluyó la correlación lineal, la prueba t emparejada y el análisis de la varianza. Se consideró estadísticamente significativa una probabilidad de pHealthy individuals were examined in terms of the pattern of activity of the masseter and temporal muscles in their anterior portion of both right and left sides, respectively, with the maximum bite force. The study consisted in seventeen adult volunteers with no sign of apparent temporomandibular dysfunction, of both genders, connected to the School of Dentistry of Piracicaba, with average age of 25 years old. The electromyography data were obtained, bilaterally, of

  16. MODIFICACIONES AGUDAS DE LOS NIVELES SÉRICOS DE CREATINA QUINASA EN ADULTOS JÓVENES SOMETIDOS AL TRABAJO DE FLEXIBILIDAD ESTÁTICA Y DE FUERZA MÁXIMA

    E. H. Dantas

    2010-09-01

    Full Text Available RESUMENLa fuerza y flexibilidad, muy importantes en entrenamiento, obtienen sus valores máximos a través de test específicos. Se sabe poco sobre sus efectos perjudiciales en el aparato músculo tendinoso. El objetivo fue verificar las modificaciones séricas de CK 24h después de estiramientos, flexibilidad estática y test 1-RM. Muestra de 14 individuos, ambos sexos (28 ± 6 años, grupo control (GC N = 7 y grupo experimental (GE N = 7, el GE fue sometido a una rutina de estiramientos (GE-AL, flexibilidad estática (GE-FLEX y test 1-RM (GE-1-RM. La antropometría con una balanza digital con estadiómetro. Las tomas de sangre, obtenidas con jeringuillas desechables y depositadas en recipientes cerrados y enviados al laboratorio. Se utilizó la técnica De Lorme y Watkins en ejercicios Supino Horizontal y Leg Press para determinar carga de 1-RM. Se realizaron 3 series de 20s de flexibilidad estática y 3 de 6 segundos de estiramiento asistido. La estadística fue el Test de Friedman con post hoc de Tukey. En el análisis intergrupos se encontraron diferencias significativas (p < .05 en valores del GE-1RM (D= 118,7 U/L, p= .02 comparando con GC. Como conclusión, los ejercicios dinámicos de fuerza máxima fueron capaces de aumentar los niveles de CK post-ejercicio. Palabras Clave: Flexibilidad estática, 1-RM, CK, daño muscular ABSTRACTStrength and flexibility, important components of a training and their maximal values are obtained through specific tests. However, little information about the damage effect in a skeletal muscle is known. The aim was to verify a serum CK changes 24 h after a lengthening and static flexibilizing routine and a maximal dynamic strength tests. The sample, was by 14 subjects (man and women, 28 ± 6 yr., control group (CG N = 7 and experimental group (EG N = 4 that was submitted a lengthening routine (EG-LG, a static flexibilizing routine (EG-FLEX and a 1-RM test (EG-1-RM. The anthropometrics were obtained by

  17. Sequence, 'subtle' alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors

    Vitale, Lorenza; Coppola, Domenico; Strippoli, Pierluigi; Frabetti, Flavia; Huntsman, Shane A; Canaider, Silvia; Casadei, Raffaella; Lenzi, Luca; Facchin, Federica; Carinci, Paolo; Zannotti, Maria

    2007-01-01

    CYYR1 is a recently identified gene located on human chromosome 21 whose product has no similarity to any known protein and is of unknown function. Analysis of expressed sequence tags (ESTs) have revealed high human CYYR1 expression in cells belonging to the diffuse neuroendocrine system (DNES). These cells may be the origin of neuroendocrine (NE) tumors. The aim of this study was to conduct an initial analysis of sequence, splicing and expression of the CYYR1 mRNA in human NE tumors. The CYYR1 mRNA coding sequence (CDS) was studied in 32 NE tumors by RT-PCR and sequence analysis. A subtle alternative splicing was identified generating two isoforms of CYYR1 mRNA differing in terms of the absence (CAG - isoform, the first described mRNA for CYYR1 locus) or the presence (CAG + isoform) of a CAG codon. When present, this specific codon determines the presence of an alanine residue, at the exon 3/exon 4 junction of the CYYR1 mRNA. The two mRNA isoform amounts were determined by quantitative relative RT-PCR in 29 NE tumors, 2 non-neuroendocrine tumors and 10 normal tissues. A bioinformatic analysis was performed to search for the existence of the two CYYR1 isoforms in other species. The CYYR1 CDS did not show differences compared to the reference sequence in any of the samples, with the exception of an NE tumor arising in the neck region. Sequence analysis of this tumor identified a change in the CDS 333 position (T instead of C), leading to the amino acid mutation P111S. NE tumor samples showed no significant difference in either CYYR1 CAG - or CAG + isoform expression compared to control tissues. CYYR1 CAG - isoform was significantly more expressed than CAG + isoform in NE tumors as well as in control samples investigated. Bioinformatic analysis revealed that only the genomic sequence of Pan troglodytes CYYR1 is consistent with the possible existence of the two described mRNA isoforms. A new 'subtle' splicing isoform (CAG + ) of CYYR1 mRNA, the sequence and

  18. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA

    Zhang, Weiying; Lu, Zhanping; Gao, Yuen [State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin (China); Ye, Lihong [State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin (China); Song, Tianqiang, E-mail: tjchi@hotmai.com [Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin (China); Zhang, Xiaodong, E-mail: zhangxd@nankai.edu.cn [State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin (China)

    2015-05-08

    Accumulating evidence indicates that microRNAs are able to act as oncogenes or tumor suppressor genes in human cancer. We previously reported that miR-520b was down-regulated in hepatocellular carcinoma (HCC) and its deregulation was involved in hepatocarcinogenesis. In the present study, we report that miR-520b suppresses cell proliferation in HCC through targeting the ten-eleven translocation 1 (TET1) mRNA. Notably, we identified that miR-520b was able to target 3′-untranslated region (3′UTR) of TET1 mRNA by luciferase reporter gene assays. Then, we revealed that miR-520b was able to reduce the expression of TET1 at the levels of mRNA and protein using reverse transcription-polymerase chain reaction and Western blotting analysis. In terms of function, 5-ethynyl-2-deoxyuridine (EdU) incorporation and colony formation assays demonstrated that the forced miR-520b expression remarkably inhibited proliferation of hepatoma cells, but TET1 overexpression could rescue the inhibition of cell proliferation mediated by miR-520b. Furthermore, anti-miR-520b enhanced proliferation of hepatoma cells, whereas silencing of TET1 abolished anti-miR-520b-induced acceleration of cell proliferation. Then, we validated that the expression levels of miR-520b were negatively related to those of TET1 mRNA in clinical HCC tissues. Thus, we conclude that miR-520b depresses proliferation of liver cancer cells through targeting 3′UTR of TET1 mRNA. Our finding provides new insights into the mechanism of hepatocarcinogenesis. - Highlights: • TET1 is a novel target gene of miR-520b. • TET1 is upregulated in clinical HCC tissues. • MiR-520b is negatively correlated with TET1 in clinical HCC tissues. • MiR-520b depresses the proliferation of HCC cells through targeting TET1 mRNA.

  19. MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA

    Feng, Guoxing [State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin (China); Shi, Hui [State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin (China); Li, Jiong; Yang, Zhe [State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin (China); Fang, Runping; Ye, Lihong [State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin (China); Zhang, Weiying, E-mail: zhwybao@nankai.edu.cn [State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin (China); Zhang, Xiaodong, E-mail: zhangxd@nankai.edu.cn [State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin (China)

    2016-04-08

    Aberrant microRNA expression has been shown to be characteristic of many cancers. It has been reported that the expression levels of miR-30e are decreased in liver cancer tissues. However, the role of miR-30e in hepatocellular carcinoma remains poorly understood. In the present study, we investigated the significance of miR-30e in hepatocarcinogenesis. Bioinformatics analysis reveals a putative target site of miR-30e in the 3′-untranslated region (3′UTR) of prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA. Moreover, luciferase reporter gene assays verified that miR-30e directly targeted 3′UTR of P4HA1 mRNA. Then, we demonstrated that miR-30e was able to reduce the expression of P4HA1 at the levels of mRNA and protein using reverse transcription-polymerase chain reaction and Western blot analysis. Enforced expression of miR-30e suppressed proliferation of HepG2 cells by 5-ethynyl-2-deoxyuridine (EdU) assay and reduced colony formation of these cells by colony formation analysis. Conversely, anti-miR-30e enhanced the proliferation of hepatoma cells in vitro. Interestingly, the ectopic expression of P4HA1 could efficiently rescue the inhibition of cell proliferation mediated by miR-30e in HepG2 cells. Meanwhile, silencing of P4HA1 abolished the anti-miR-30e-induced proliferation of cells. Clinically, quantitative real-time PCR showed that miR-30e was down-regulated in liver tumor tissues relative to their peritumor tissues. The expression levels of miR-30e were negatively correlated to those of P4HA1 mRNA in clinical liver tumor tissues. Thus, we conclude that miR-30e suppresses proliferation of hepatoma cells through targeting P4HA1 mRNA. Our finding provides new insights into the mechanism of hepatocarcinogenesis. - Highlights: • P4HA1 is a novel target gene of miR-30e. • P4HA1 is increased in clinical HCC tissues. • MiR-30e is negatively correlated with P4HA1 in clinical HCC tissues. • MiR-30e suppresses the proliferation of HCC cells through

  20. Transformación de los modelos mentales sobre los conceptos de fuerza y campo eléctrico mediante la metodología Webquest, en estudiantes universitarios de Ingeniería

    Ester López D

    2014-09-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2015v32n1p2 El presente trabajo describe una investigación experimental, realizada en educación superior que persigue transformar los modelos mentales alternativos de los estudiantes sobre los conceptos de fuerza y campo eléctrico[1]. La experiencia se diseña, desarrolla y explica a la luz de tres referentes teóricos: la teoría de aprendizaje significativo de Ausubel, la teoría de los modelos mentales de Johnson-Laird y la teoría Socio histórica de Vygotsky. Se utilizó la metodología Webquest (WQ, que ha mostrado ser eficiente para promover la motivación o disposición hacia el aprendizaje y el trabajo cooperativo de los estudiantes. La muestra corresponde a un grupo de estudiantes de Ingeniería informática que cursan la asignatura Electromagnetismo. La modalidad pre-postest, a través de un cuestionario, que permite “externalizar” los modelos mentales que los alumnos construyen, determina que los estudiantes logran transformar sus modelos mentales iniciales, alternativos, hacia una construcción conceptual más acorde con las leyes físicas correspondientes, lo que, además, permite inferir sobre la efectividad de su aprendizaje. También se logra fomentar y fortalecer en los alumnos, el trabajo cooperativo, la discusión critica así como la apropiación del lenguaje científico adecuado para expresar en forma asertiva las ideas. [1] En este trabajo colaboraron como tesistas de la carrera de Pedagogía en Física los alumnos Catalina Pulgar Silva, Juan Carlos Ibacache Vera y Marco Toledo Ibáñez.

  1. Análisis de las adaptaciones agudas al entrenamiento de fuerza máxima mediante el estudio de las modificaciones del rendimiento mecánico del tren superior

    Eliseo Iglesias Soler

    2007-03-01

    Full Text Available El propósito del presente trabajo fue valorar el efecto agudo de dos sesiones de fuerza máxima sobre el rendimiento mecánico inmediatamente posterior. En 10 sujetos varones se obtuvieron las cargas correspondientes a una repetición máxima (1RM y a la máxima potencia en la ejecución concéntrica de press banca. Cinco días más tarde se realizaron dos sesiones de entrenamiento. En cada una se llevaron a cabo 6 series de 2 repeticiones de press banca concéntrico, al 90 % de 1RM, con pausas mínimas de 3'. Antes e inmediatamente después de cada sesión se midió la potencia desarrollada, tanto con la carga de máxima potencia como con el 90 % de 1RM. El análisis de los resultados no reflejó diferencias significativas en el rendimiento con cargas de máxima potencia. Con el 90 % disminuyó de forma significativa (p < 0,05 al final de la segunda sesión. No se halló correlación significativa entre 1RM y las diferencias entre los valores finales e iniciales con las cargas de máxima potencia individual. La correlación fue significativa entre 1RM y las diferencias entre la potencia final e inicial al 90 % de 1RM en la primera sesión, tanto en valores reales como porcentuales (r = –0,631 y r = –0,678 respectivamente

  2. La terminación de políticas y organizaciones públicas. El caso de la extinción de Luz y Fuerza del Centro en México

    Jesús Rubio Campos

    2016-05-01

    Full Text Available Esta investigación analiza los modelos y estrategias utilizadas durante el proceso de terminación de políticas públicas, tema que ha sido poco estudiado hasta el momento. Para cumplir con dicho objetivo, se decidió utilizar un estudio de caso instrumental, el de la extinción de Luz y Fuerza del Centro (LyFC en México, a fin de identificar variables y su comportamiento en los patrones de terminación que sirvan de marco de análisis para casos similares. Los marcos teóricos sobre la terminación de políticas y organizaciones públicas descritos en la literatura sobre el tema resultaron muy apropiados para explicar el proceso de extinción de LyFC. Destacan la figura del “terminador”, la compensación por encima de lo establecido bajo condiciones normales a los afectados por la política, la desacreditación de la oposición con el uso de los medios de comunicación, el elemento sorpresa, la no intromisión del legislativo, crear divisiones organizacionales, dar claridad respecto a los pasos siguientes y el contar con una clara estrategia para la implementación del plan de terminación. Las excepciones al modelo fueron el uso sorpresivo de la fuerza pública para tomar las instalaciones de LyFC, así como el congelamiento de las cuentas bancarias del Sindicato Mexicano de Electricistas (SME por la falta de “toma de nota” y la colaboración de un grupo adverso al SME, conformado por trabajadores de la Comisión Federal de Electricidad (CFE afiliados al Sindicato Único de Trabajadores Electricistas de la República Mexicana (SUTERM. Otro aprendizaje que nos deja el caso, es que en este tipo de intervenciones para la terminación de políticas y organizaciones públicas, debería prevalecer el cuidado de la ética en el ejercicio de la función pública, pues la terminación de políticas públicas no debe abordarse solamente desde un punto de vista meramente técnico, sino que debe entenderse que las decisiones de pol

  3. Desarrollo de un modelo generalizado para realimentación de fuerza y torque en cirugía cardiotorácica robótica mínimamente invasiva: determinación de condiciones y restricciones Development of a generalized model for force and torque feedback in robotic minimally invasive cardiothoracic surgery: identification of conditions and restrictions

    Vera Pérez

    2011-07-01

    Full Text Available INTRODUCCIÓN: los procedimientos de cirugía cardiotorácica mínimamente invasiva (MICS, su sigla en Inglés buscan reducir las complicaciones de las grandes disecciones. No obstante, ante la falta de contacto directo con el tejido por parte del cirujano, éste recibe una sensación parcial de tacto y fuerza, lo que puede originar errores de procedimiento, inadecuada fuerza aplicada al tejido y fatiga durante el acto quirúrgico. La inclusión de dispositivos robóticos con la técnica MICS ha potencializado las habilidades del cirujano para la manipulación de los tejidos, y aunque los desarrollos del mercado no cuentan aún con retroalimentación táctil, se trabaja en prototipos robóticos que incorporan realimentación de fuerza y torque. OBJETIVO: proponer las condiciones y restricciones relacionadas con la incorporación de realimentación de fuerza y torque en MICS robótica, aplicables a diferentes configuraciones de manipuladores, y analizar la implementación de dichas condiciones en un simulador quirúrgico. MATERIAL Y MÉTODOS: partiendo del análisis de necesidades durante procedimientos cardiotorácicos y las condiciones de cirugía mínimamente invasiva, se identificaron los requerimientos para garantizar reflexión de fuerza y se realizó un análisis matemático de dichas consideraciones. Finalmente, se verificaron los análisis matemáticos mediante técnicas de modelización y simulación utilizando la plataforma computacional Matlab®. RESULTADOS: se argumentaron tres tipos de consideraciones: a Cinemático: la existencia de un punto fijo, las formas de garantizarlo durante procedimientos MICS robóticos, y las trayectorias de movimiento que el manipulador sigue en aplicaciones de cirugía cardiotorácica; b Dinámico: la repercusión de fuerzas externas en el manipulador y la manera de considerarlas en el desarrollo de controladores que permitan al cirujano percibir una sensación de contacto con el tejido; c Sensorial

  4. Adrenal-dependent and -independent stress-induced Per1 mRNA in hypothalamic paraventricular nucleus and prefrontal cortex of male and female rats.

    Chun, Lauren E; Christensen, Jenny; Woodruff, Elizabeth R; Morton, Sarah J; Hinds, Laura R; Spencer, Robert L

    2018-01-01

    Oscillating clock gene expression gives rise to a molecular clock that is present not only in the body's master circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN), but also in extra-SCN brain regions. These extra-SCN molecular clocks depend on the SCN for entrainment to a light:dark cycle. The SCN has limited neural efferents, so it may entrain extra-SCN molecular clocks through its well-established circadian control of glucocorticoid hormone secretion. Glucocorticoids can regulate the normal rhythmic expression of clock genes in some extra-SCN tissues. Untimely stress-induced glucocorticoid secretion may compromise extra-SCN molecular clock function. We examined whether acute restraint stress during the rat's inactive phase can rapidly (within 30 min) alter clock gene (Per1, Per2, Bmal1) and cFos mRNA (in situ hybridization) in the SCN, hypothalamic paraventricular nucleus (PVN), and prefrontal cortex (PFC) of male and female rats (6 rats per treatment group). Restraint stress increased Per1 and cFos mRNA in the PVN and PFC of both sexes. Stress also increased cFos mRNA in the SCN of male rats, but not when subsequently tested during their active phase. We also examined in male rats whether endogenous glucocorticoids are necessary for stress-induced Per1 mRNA (6-7 rats per treatment group). Adrenalectomy attenuated stress-induced Per1 mRNA in the PVN and ventral orbital cortex, but not in the medial PFC. These data indicate that increased Per1 mRNA may be a means by which extra-SCN molecular clocks adapt to environmental stimuli (e.g. stress), and in the PFC this effect is largely independent of glucocorticoids.

  5. Low ERCC1 mRNA and protein expression are associated with worse survival in cervical cancer patients treated with radiation alone

    Doll, Corinne M.; Prystajecky, Michael; Eliasziw, Misha; Klimowicz, Alexander C.; Petrillo, Stephanie K.; Craighead, Peter S.; Hao, Desiree; Diaz, Roman; Lees-Miller, Susan P.; Magliocco, Anthony M.

    2010-01-01

    Purpose: To evaluate the association of excision repair cross-complementation group 1 (ERCC1) expression, using both mRNA and protein expression analysis, with clinical outcome in cervical cancer patients treated with radical radiation therapy (RT). Experimental design: Patients (n = 186) with locally advanced cervical cancer, treated with radical RT alone from a single institution were evaluated. Pre-treatment FFPE biopsy specimens were retrieved from 112 patients. ERCC1 mRNA level was determined by real-time PCR, and ERCC1 protein expression (FL297, 8F1) was measured using quantitative immunohistochemistry (AQUA (registered) ). The association of ERCC1 status with local response, 10-year disease-free (DFS) and overall survival (OS) was analyzed. Results: ERCC1 protein expression levels using both FL297 and 8F1 antibodies were determined for 112 patients; mRNA analysis was additionally performed in 32 patients. Clinical and outcome factors were comparable between the training and validation sets. Low ERCC1 mRNA expression status was associated with worse OS (17.9% vs 50.1%, p = 0.046). ERCC1 protein expression using the FL297 antibody, but not the 8F1 antibody, was significantly associated with both OS (p = 0.002) and DFS (p = 0.010). After adjusting for pre-treatment hemoglobin in a multivariate analysis, ERCC1 FL297 expression status remained statistically significant for OS [HR 1.9 (1.1-3.3), p = 0.031]. Conclusions: Pre-treatment tumoral ERCC1 mRNA and protein expression, using the FL297 antibody, are predictive factors for survival in cervical cancer patients treated with RT, with ERCC1 FL297 expression independently associated with survival. These results identify a subset of patients who may derive the greatest benefit from the addition of cisplatin chemotherapy.

  6. The Drosophila nerfin-1 mRNA requires multiple microRNAs to regulate its spatial and temporal translation dynamics in the developing nervous system.

    Kuzin, Alexander; Kundu, Mukta; Brody, Thomas; Odenwald, Ward F

    2007-10-01

    The mRNA encoding the Drosophila Zn-finger transcription factor Nerfin-1, required for CNS axon pathfinding events, is subject to post-transcriptional silencing. Although nerfin-1 mRNA is expressed in many neural precursor cells including all early delaminating CNS neuroblasts, the encoded Nerfin-1 protein is detected only in the nuclei of neural precursors that divide just once to generate neurons and then only transiently in nascent neurons. Using a nerfin-1 promoter-controlled reporter transgene, replacement of the nerfin-1 3' UTR with the viral SV-40 3' UTR releases the neuroblast translational block and prolongs reporter protein expression in neurons. Comparative genomics analysis reveals that the nerfin-1 mRNA 3' UTR contains multiple highly conserved sequence blocks that either harbor and/or overlap 21 predicted binding sites for 18 different microRNAs. To determine the functional significance of these microRNA-binding sites and less conserved microRNA target sites, we have studied their ability to block or limit the expression of reporter protein in nerfin-1-expressing cells during embryonic development. Our results indicate that no single microRNA is sufficient to fully inhibit protein expression but rather multiple microRNAs that target different binding sites are required to block ectopic protein expression in neural precursor cells and temporally restrict expression in neurons. Taken together, these results suggest that multiple microRNAs play a cooperative role in the post-transcriptional regulation of nerfin-1 mRNA, and the high degree of microRNA-binding site evolutionary conservation indicates that all members of the Drosophila genus employ a similar strategy to regulate the onset and extinction dynamics of Nerfin-1 expression.

  7. Increased expression of cyclin B1 mRNA coincides with diminished G2-phase arrest in irradiated HeLa cells treated with staurosporine or caffeine

    Bernhard, E.J.; Maity, A.; McKenna, W.G.; Muschel, R.J.

    1994-01-01

    The irradiation of cells results in delayed progression through the G 2 phase of the cell cycle. Treatment of irradiated HeLa cells with caffeine greatly reduces the G 2 -phase delay, while caffeine does not alter progression of cells through the cell cycle in unirradiated cells. In this report we demonstrate that treatment of HeLa cells with the kinase inhibitor staurosporine, but not with the inhibitor H7, also results in a reduction of the G 2 -phase arrest after irradiation. Cell cycle progression in unirradiated cells is unaffected by 4.4 nM (2ng/ml) staurosporine, which releases the radiation-induced G 2 -phase arrest. In HeLa cells, the G 2 -phase delay after irradiation in S phase is accompanied by decreased expression of cyclin B1 mRNA. Coincident with the reduction in G 2 -phase delay, we observed an increase in cyclin B1 mRNA accumulation in irradiated, staurosporine-treated cells compared to cells treated with irradiation alone. Caffeine treatment of irradiated HeLa cells also resulted in an elevation in the levels of cyclin B1 message. These results support the hypothesis that diminished cyclin B1 mRNA levels influence G 2 -phase arrest to some degree. The findings that both staurosporine and caffeine treatments reverse the depression in cyclin B1 expression suggest that these two compounds may act on a common pathway of cell cycle control in response to radiation injury. 33 refs., 6 figs

  8. Improved differentiation of umbilical cord blood-derived mesenchymal stem cells into insulin-producing cells by PDX-1 mRNA transfection.

    Van Pham, Phuc; Thi-My Nguyen, Phuoc; Thai-Quynh Nguyen, Anh; Minh Pham, Vuong; Nguyen-Tu Bui, Anh; Thi-Tung Dang, Loan; Gia Nguyen, Khue; Kim Phan, Ngoc

    2014-06-01

    Numerous studies have sought to identify diabetes mellitus treatment strategies with fewer side effects. Mesenchymal stem cell (MSC) therapy was previously considered as a promising therapy; however, it requires the cells to be trans-differentiated into cells of the pancreatic-endocrine lineage before transplantation. Previous studies have shown that PDX-1 expression can facilitate MSC differentiation into insulin-producing cells (IPCs), but the methods employed to date use viral or DNA-based tools to express PDX-1, with the associated risks of insertional mutation and immunogenicity. Thus, this study aimed to establish a new method to induce PDX-1 expression in MSCs by mRNA transfection. MSCs were isolated from human umbilical cord blood and expanded in vitro, with stemness confirmed by surface markers and multipotentiality. MSCs were transfected with PDX-1 mRNA by nucleofection and chemically induced to differentiate into IPCs (combinatorial group). This IPC differentiation was then compared with that of untransfected chemically induced cells (inducer group) and uninduced cells (control group). We found that PDX-1 mRNA transfection significantly improved the differentiation of MSCs into IPCs, with 8.3±2.5% IPCs in the combinatorial group, 3.21±2.11% in the inducer group and 0% in the control. Cells in the combinatorial group also strongly expressed several genes related to beta cells (Pdx-1, Ngn3, Nkx6.1 and insulin) and could produce C-peptide in the cytoplasm and insulin in the supernatant, which was dependent on the extracellular glucose concentration. These results indicate that PDX-1 mRNA may offer a promising approach to produce safe IPCs for clinical diabetes mellitus treatment. Copyright © 2014 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

  9. Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model

    Maryna Perepelyuk

    2016-01-01

    Full Text Available Small interfering RNA (siRNA is effective in silencing critical molecular pathways in cancer. The use of this tool as a treatment modality is limited by lack of an intelligent carrier system to enhance the preferential delivery of this molecule to specific targets in vivo. In the present study, the in vivo behavior of novel anti-NTSR1-mAb-functionalized antimutant K-ras siRNA-loaded hybrid nanoparticles, delivered by i.p. injection to non-small-cell lung cancer in mice models, was investigated and compared to that of a naked siRNA formulation. The siRNA in anti-NTSR1-mAb-functionalized hybrid nanoparticles was preferentially accumulated in tumor-bearing lungs and metastasized tumor for at least 48 hours while the naked siRNA formulation showed lack of preferential accumulation in all of the organs monitored. The plasma terminal half-life of nanoparticle-delivered siRNA was 11 times higher (17–1.5 hours than that of the naked siRNA formulation. The mean residence time and AUClast were 3.4 and 33 times higher than the corresponding naked siRNA formulation, respectively. High-performance liquid chromatography analysis showed that the hybrid nanoparticle carrier system protected the encapsulated siRNA against degradation in vivo. Our novel anti-NTSR1-mAb-functionalized hybrid nanoparticles provide a useful platform for in vivo targeting of siRNA for both experimental and clinical purposes.

  10. Pubertal Escape From Estradiol Negative Feedback in Ewe Lambs Is Not Accounted for by Decreased ESR1 mRNA or Protein in Kisspeptin Neurons.

    Bedenbaugh, Michelle N; D'Oliveira, Marcella; Cardoso, Rodolfo C; Hileman, Stanley M; Williams, Gary L; Amstalden, Marcel

    2018-01-01

    In this study, we investigated whether decreased sensitivity to estradiol negative feedback is associated with reduced estrogen receptor α (ESR1) expression in kisspeptin neurons as ewe lambs approach puberty. Lambs were ovariectomized and received no implant (OVX) or an implant containing estradiol (OVX+E). In the middle arcuate nucleus (mARC), ESR1 messenger RNA (mRNA) was greater in OVX than OVX+E lambs but did not differ elsewhere. Post hoc analysis of luteinizing hormone (LH) secretion from OVX+E lambs revealed three patterns of LH pulsatility: low [1 to 2 pulses per 12 hours; low frequency (LF), n = 3], moderate [6 to 7 pulses per 12 hours; moderate frequency (MF), n = 6], and high [>10 pulses per 12 hours; high frequency (HF), n = 5]. The percentage of kisspeptin neurons containing ESR1 mRNA in the preoptic area did not differ among HF, MF, or LF groups. However, the percentage of kisspeptin neurons containing ESR1 mRNA in the mARC was greater in HF (57%) than in MF (36%) or LF (27%) lambs and did not differ from OVX (50%) lambs. A higher percentage of kisspeptin neurons contained ESR1 protein in all regions of the arcuate nucleus (ARC) in OVX compared with OVX+E lambs. There were no differences in ESR1 protein among the HF, MF, or LF groups in the preoptic area or ARC. Contrary to our hypothesis, increases in LH pulsatility were associated with enhanced ESR1 mRNA abundance in kisspeptin neurons in the ARC, and absence of estradiol increased the percentage of kisspeptin neurons containing ESR1 protein in the ARC. Therefore, changes in the expression of ESR1, particularly in kisspeptin neurons in the ARC, do not explain the pubertal escape from estradiol negative feedback in ewe lambs. Copyright © 2018 Endocrine Society.

  11. Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5'-UTR.

    McAninch, Damian S; Heinaman, Ashley M; Lang, Cara N; Moss, Kathryn R; Bassell, Gary J; Rita Mihailescu, Mihaela; Evans, Timothy L

    2017-07-25

    G quadruplex structures have been predicted by bioinformatics to form in the 5'- and 3'-untranslated regions (UTRs) of several thousand mature mRNAs and are believed to play a role in translation regulation. Elucidation of these roles has primarily been focused on the 3'-UTR, with limited focus on characterizing the G quadruplex structures and functions in the 5'-UTR. Investigation of the affinity and specificity of RNA binding proteins for 5'-UTR G quadruplexes and the resulting regulatory effects have also been limited. Among the mRNAs predicted to form a G quadruplex structure within the 5'-UTR is the survival motor neuron domain containing 1 (SMNDC1) mRNA, encoding a protein that is critical to the spliceosome. Additionally, this mRNA has been identified as a potential target of the fragile X mental retardation protein (FMRP), whose loss of expression leads to fragile X syndrome. FMRP is an RNA binding protein involved in translation regulation that has been shown to bind mRNA targets that form G quadruplex structures. In this study we have used biophysical methods to investigate G quadruplex formation in the 5'-UTR of SMNDC1 mRNA and analyzed its interactions with FMRP. Our results show that SMNDC1 mRNA 5'-UTR forms an intramolecular, parallel G quadruplex structure comprised of three G quartet planes, which is bound specifically by FMRP both in vitro and in mouse brain lysates. These findings suggest a model by which FMRP might regulate the translation of a subset of its mRNA targets by recognizing the G quadruplex structure present in their 5'-UTR, and affecting their accessibility by the protein synthesis machinery.

  12. Circulating Tyrosinase and MART-1 mRNA does not Independently Predict Relapse or Survival in Patients with AJCC Stage I–II Melanoma

    Schmidt, Henrik; Sørensen, Boe S; Sjoegren, Pia

    2006-01-01

    The detection of melanoma cells in peripheral blood has been proposed to select patients with a high risk of relapse. In this study, tyrosinase and melanoma antigen recognized by T cells 1 (MART-1) mRNA expression was evaluated in serial samples obtained before definitive surgery and during follow......-up in patients with American Joint Committee on Cancer stage I-II melanoma. Serial samples (n=2,262) were collected from 236 patients from 1997 to 2002. Analyses of the RNA samples were performed with a calibrated reverse transcriptase-PCR assay. Gender, age, primary tumor site, ulceration, thickness, Clark...

  13. Is the standard dose rate for de-contamination, 0.23 mc-Sv/hr, truly 1 mSv/year?

    Furuta, Sadaaki

    2014-01-01

    Examined is the validity of the standard dose rates in the title, which have been additionally defined by Ministry of the Environment (ME) to the measures of Fukushima Nuclear Power Plant Accident. The standard 0.23 mc-Sv/hr is the sum of natural ambient dose rate 0.04 mc-Sv/hr in average of Japan as measured with NaI scintillation surveymeter, plus additional accidental exposure dose 1 mSv/y, which is defined equivalent to 0.19 mc-Sv/hr. Here, the equation of addition 0.04+0.19 mc-Sv/hr is not exactly correct because the unit of each dose value has different means as follows. The natural dose is derived from the value 5.8 mc-R/hr (0.038 mc-Sv/hr, effective dose) of the average national natural dose data (2011) of Ministry of Education, Culture, Sports, Science and Technology. However, if the measurement is done with the surveymeter which practically gives 1 cm dose equivalent, the rate is calculated to be 0.06 mc-Sv/hr. When the Fukushima prefectural natural dose rate 6.4 mc-R/hr is employed, the calculation gives 0.07 mc-Sv/hr. ME defines the additional doses to be 0.19 mc-Sv/hr and 1 mSv/y, which are derived from the calculation: (0.19 mc-Sv/hr x 8 hr outdoor + 0.19 mc-Sv/hr x 0.4 indoor, shielded) x 365 d/y= 1 mSv/y. The dose is assumed to be measurable with the surveymeter (1 cm dose equivalent) and thereby calculation, if the source is mainly "1"3"4Cs and "1"3"7Cs, gives the effective dose of 0.32 mc-Sv/hr to be managed by the meter. As this, the effective dose unit and 1 cm equivalent dose unit are used for calculation of the administrative standard dose rate of 1 mSv/y, which should be recognized by both radiological experts and administration for the explanation to general public. (T.T.)

  14. Design, fabrication and testing of a 56 mm bore twin-aperture 1 m long dipole magnet made with SSC type cable

    Ostler, J.; Perini, D.; Russenschuck, S.; Siegel, N.; Siemko, A.; Trinquart, G.; Walckiers, L.; Weterings, W. [CERN, Geneva (Switzerland)

    1996-07-01

    In the framework of the LHC superconducting dipole magnet model program, a 56 mm bore, twin-aperture dipole model 1 m long, using existing cables of the standard SSC type, was launched to initiate studies of lower field magnets with smaller strand size cables for a 7 TeV collider. This model was designed, built, assembled and tested at CERN and reached a peak field of 9.7 T at 1.8 K. The paper reviews the main design principles, presents the fabrication and assembly procedures and finally discusses the overall test results.

  15. Design, fabrication and testing of a 56 mm bore twin-aperture 1 m long dipole magnet made with SSC type cable

    Ostler, J.; Perini, D.; Russenschuck, S.; Siegel, N.; Siemko, A.; Trinquart, G.; Walckiers, L.; Weterings, W.

    1996-01-01

    In the framework of the LHC superconducting dipole magnet model program, a 56 mm bore, twin-aperture dipole model 1 m long, using existing cables of the standard SSC type, was launched to initiate studies of lower field magnets with smaller strand size cables for a 7 TeV collider. This model was designed, built, assembled and tested at CERN and reached a peak field of 9.7 T at 1.8 K. The paper reviews the main design principles, presents the fabrication and assembly procedures and finally discusses the overall test results

  16. Relationship between serum IGF-1 and skeletal muscle IGF-1 mRNA expression to phosphocreatine recovery after exercise in obese men with reduced GH.

    Hamarneh, Sulaiman R; Murphy, Caitlin A; Shih, Cynthia W; Frontera, Walter; Torriani, Martin; Irazoqui, Javier E; Makimura, Hideo

    2015-02-01

    GH and IGF-1 are believed to be physiological regulators of skeletal muscle mitochondria. The objective of this study was to examine the relationship between GH/IGF-1 and skeletal muscle mitochondria in obese subjects with reduced GH secretion in more detail. Fifteen abdominally obese men with reduced GH secretion were treated for 12 weeks with recombinant human GH. Subjects underwent (31)P-magnetic resonance spectroscopy to assess phosphocreatine (PCr) recovery as an in vivo measure of skeletal muscle mitochondrial function and percutaneous muscle biopsies to assess mRNA expression of IGF-1 and mitochondrial-related genes at baseline and 12 weeks. At baseline, skeletal muscle IGF-1 mRNA expression was significantly associated with PCr recovery (r = 0.79; P = .01) and nuclear respiratory factor-1 (r = 0.87; P = .001), mitochondrial transcription factor A (r = 0.86; P = .001), peroxisome proliferator-activated receptor (PPAR)γ (r = 0.72; P = .02), and PPARα (r = 0.75; P = .01) mRNA expression, and trended to an association with PPARγ coactivator 1-α (r = 0.59; P = .07) mRNA expression. However, serum IGF-1 concentration was not associated with PCr recovery or any mitochondrial gene expression (all P > .10). Administration of recombinant human GH increased both serum IGF-1 (change, 218 ± 29 μg/L; P IGF-1 mRNA in muscle (fold change, 2.1 ± 0.3; P = .002). Increases in serum IGF-1 were associated with improvements in total body fat (r = -0.53; P = .04), trunk fat (r = -0.55; P = .03), and lean mass (r = 0.58; P = .02), but not with PCr recovery (P > .10). Conversely, increase in muscle IGF-1 mRNA was associated with improvements in PCr recovery (r = 0.74; P = .02), but not with body composition parameters (P > .10). These data demonstrate a novel association of skeletal muscle mitochondria with muscle IGF-1 mRNA expression, but independent of serum IGF-1 concentrations.

  17. Solubility of La, Pr, Eu, Er and Lu in a media of 1M ionic force of NaCl by 303 K

    Ramirez G, J.J.; Solache R, M.J.; Jimenez R, M.; Rojas H, A.

    2002-01-01

    The solubility and the solubility product of La, Pr, Eu, Er and Lu in media of 1M ionic force of NaCl by 303 K was determined, by means of a radiochemical method and the pLn - pCH diagrams in free conditions of CO 2 were constructed. Moreover, the non saturation and the saturated zones and with them the pCH precipitation bound were determined. Finally a comparison among the obtained data in this work and those reported in the literature in several media was realized. (Author)

  18. Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing.

    Satoshi Iizuka

    Full Text Available Head and neck squamous cell carcinoma (HNSCC exhibits increased expression of cyclin D1 (CCND1. Previous studies have shown a correlation between poor prognosis of HNSCC and cyclin D1 overexpression. tRNase ZL-utilizing efficacious gene silencing (TRUE gene silencing is one of the RNA-mediated gene expression control technologies that have therapeutic potential. This technology is based on a unique enzymatic property of mammalian tRNase ZL, which is that it can cleave any target RNA at any desired site by recognizing a pre-tRNA-like complex formed between the target RNA and an artificial small guide RNA (sgRNA. In this study, we designed several sgRNAs targeting human cyclin D1 mRNA to examine growth inhibition of HNSCC cells. Transfection of certain sgRNAs decreased levels of cyclin D1 mRNA and protein in HSC-2 and HSC-3 cells, and also inhibited their proliferation. The combination of these sgRNAs and cisplatin showed more than additive inhibition of cancer cell growth. These findings demonstrate that TRUE gene silencing of cyclin D1 leads to inhibition of the growth of HNSCC cells and suggest that these sgRNAs alone or combined with cisplatin may be a useful new therapy for HNSCCs.

  19. Selective regulation of YB-1 mRNA translation by the mTOR signaling pathway is not mediated by 4E-binding protein.

    Lyabin, D N; Ovchinnikov, L P

    2016-03-02

    The Y-box binding protein 1 (YB-1) is a key regulator of gene expression at the level of both translation and transcription. The mode of its action on cellular events depends on its subcellular distribution and the amount in the cell. So far, the regulatory mechanisms of YB-1 synthesis have not been adequately studied. Our previous finding was that selective inhibition of YB-1 mRNA translation was caused by suppression of activity of the mTOR signaling pathway. It was suggested that this event may be mediated by phosphorylation of the 4E-binding protein (4E-BP). Here, we report that 4E-BP alone can only slightly inhibit YB-1 synthesis both in the cell and in vitro, although it essentially decreases binding of the 4F-group translation initiation factors to mRNA. With inhibited mTOR kinase, the level of mRNA binding to the eIF4F-group factors was decreased, while that to 4E-BP1 was increased, as was observed for both mTOR kinase-sensitive mRNAs and those showing low sensitivity. This suggests that selective inhibition of translation of YB-1 mRNA, and probably some other mRNAs as well, by mTOR kinase inhibitors is not mediated by the action of the 4E-binding protein upon functions of the 4F-group translation initiation factors.

  20. Effect of metal properties of casts of steel-15Kh1M1FL on the crack resistance at 565 deg C

    Gladshtejn, V.I.; Sheshenev, M.F.

    1976-01-01

    Results are given of prolonged tests of the metal of industrial casts with various fluidity limits. It has been shown experimentally that a quite satisfactory crack resistance is characteristic of a metal with a fluidity limit in the range 30-50 kgf/mm 2 . Metallographic studies have been conducted. Upon variation of the structure and properties of the 15Kh1M1FL steel during operation, the rate of growth of small cracks (up to 2.0 mm) decreases almost by 3 orders of ten (from 1.4x10 -4 to 2.0x10 -7 mm/hour). Subsequent structural changes during prolonged operation (over 50000 hours) result in a gradual increase in the rate of crack growth. At the same time resistance towards appearance of the impermissible high rate of the crack growth, Ksub(10sup(-3)), diminishes monotonically with the operation time. The metal of industrial 15Kh1M1FL steel casts has good crack resistance (Ksub(10sup(-3)) =30-70 kgf/mmsup(3/2) and Vsub(ef) =) kgf/mm 2 ) and a satisfactory local plasticity (critical opening being no more than 0.20 mm for 10 3 hours)