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Sample records for fsa project cell

  1. Developing a Projective Drawing Test: Experiences with the Face Stimulus Assessment (FSA).

    Science.gov (United States)

    Betts, Donna J.

    2003-01-01

    Describes the experience of creating and working with the Face Stimulus Assessment (FSA). Six samples of the FSA completed by clients with multiple disabilities are presented. As the FSA is a work in progress and has yet to be established as a valid and reliable assessment, implications for further research are also discussed. (Contains 32…

  2. SU-C-204-05: Magnetic Resonance-Induced Adaptive Response to Orthovoltage Radiation Therapy in FSa and SA-NH Mouse Tumor Cell Lines

    Energy Technology Data Exchange (ETDEWEB)

    Mendel, K; Miller, R; Murley, J; Sadinski, M; Grdina, D [University of Chicago, Chicago, IL (United States)

    2016-06-15

    Purpose: To assess the effect of pre-treatment Magnetic Resonance Imaging (MRI) on cell survival following orthovoltage radiation therapy. Methods: This in vitro study examined the survival of FSa cells (extracted from methylcholanthrene-induced fibrosarcoma in the flank of a C3H female mouse) and SA-NH cells (derived from a spontaneously arising murine sarcoma tumor) having undergone an MRI scan prior to radiation exposure. Cell cultures were kept at 37 C, in a humidified environment with 5% CO2, and were grown to confluence prior to the start of the experiment. Each cell culture underwent two, 25 minute MRIs spaced 24 hours apart using a standard brain imaging protocol. The cultures were exposed to a 2 Gy dose of radiation beginning 15 minutes after the end of each MRI scan. Irradiations were performed by a Philips RT250 X-ray generator at 250 kVp and 15 mA. All MR imaging was performed on a 1.5 T Philips Achieva scanner using a head and neck vasculature coil. Results: Cells given an MRI scan prior to radiation exhibited an increase in mean surviving fraction of 10.8% and 9.6% in FSa and SA-NH cells, respectively. The difference was found to be statistically significant in both cell types by a student two-tailed t test with P = 0.011 and P < 0.001 for FSa and SA-NH, respectively. Conclusion: MRI may cause an increase in radio-resistance in FSa and SA-NH cells. If this biological effect is found to be consistent across other cell types and voltage ranges, these results could help inform treatment planning by improving our understanding of the joint effects of MRI and ionizing radiation. This work was supported in part under NIH grant numbers T32 EB002103, NCI R01-CA 132998, DOE Low Dose Program/Project Grant DE-413 SC0001271. DJ Grdina is a paid consultant to Pinnacle Biologics. DJ Grdina and JS Murley are minority equity partners in Pinnacle Oncology LLC.

  3. SU-C-204-05: Magnetic Resonance-Induced Adaptive Response to Orthovoltage Radiation Therapy in FSa and SA-NH Mouse Tumor Cell Lines

    International Nuclear Information System (INIS)

    Mendel, K; Miller, R; Murley, J; Sadinski, M; Grdina, D

    2016-01-01

    Purpose: To assess the effect of pre-treatment Magnetic Resonance Imaging (MRI) on cell survival following orthovoltage radiation therapy. Methods: This in vitro study examined the survival of FSa cells (extracted from methylcholanthrene-induced fibrosarcoma in the flank of a C3H female mouse) and SA-NH cells (derived from a spontaneously arising murine sarcoma tumor) having undergone an MRI scan prior to radiation exposure. Cell cultures were kept at 37 C, in a humidified environment with 5% CO2, and were grown to confluence prior to the start of the experiment. Each cell culture underwent two, 25 minute MRIs spaced 24 hours apart using a standard brain imaging protocol. The cultures were exposed to a 2 Gy dose of radiation beginning 15 minutes after the end of each MRI scan. Irradiations were performed by a Philips RT250 X-ray generator at 250 kVp and 15 mA. All MR imaging was performed on a 1.5 T Philips Achieva scanner using a head and neck vasculature coil. Results: Cells given an MRI scan prior to radiation exhibited an increase in mean surviving fraction of 10.8% and 9.6% in FSa and SA-NH cells, respectively. The difference was found to be statistically significant in both cell types by a student two-tailed t test with P = 0.011 and P < 0.001 for FSa and SA-NH, respectively. Conclusion: MRI may cause an increase in radio-resistance in FSa and SA-NH cells. If this biological effect is found to be consistent across other cell types and voltage ranges, these results could help inform treatment planning by improving our understanding of the joint effects of MRI and ionizing radiation. This work was supported in part under NIH grant numbers T32 EB002103, NCI R01-CA 132998, DOE Low Dose Program/Project Grant DE-413 SC0001271. DJ Grdina is a paid consultant to Pinnacle Biologics. DJ Grdina and JS Murley are minority equity partners in Pinnacle Oncology LLC.

  4. FSA 2002 Digital Orthophoto Metadata

    Data.gov (United States)

    Minnesota Department of Natural Resources — Metadata for the 2002 FSA Color Orthophotos Layer. Each orthophoto is represented by a Quarter 24k Quad tile polygon. The polygon attributes contain the quarter-quad...

  5. 7 CFR 1230.634 - FSA county office report.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... report. The FSA county office will notify the FSA State office of the results of the referendum. Each FSA county office will transmit the results of the referendum in its county to the FSA State office. Such...

  6. FSA 2003-2004 Digital Orthophoto Metadata

    Data.gov (United States)

    Minnesota Department of Natural Resources — Metadata for the 2003-2004 FSA Color Orthophotos Layer. Each orthophoto is represented by a Quarter 24k Quad tile polygon. The polygon attributes contain the...

  7. Electricity from photovoltaic solar cells: Flat-Plate Solar Array Project final Report. Volume II: Silicon material

    OpenAIRE

    Lutwack, R.

    1986-01-01

    The Flat-Plate Solar Array (FSA) Project, funded by the U.S. Government and managed by the Jet Propulsion Laboratory, was formed in 1975 to develop the module/array technology needed to attain widespread terrestrial use of photovoltaics by 1985. To accomplish this, the FSA Project established and managed an Industry, University, and Federal Government Team to perform the needed research and development. The goal of the Silicon Material Task, a part of the FSA Project, was to develop and ...

  8. Fuel cells: Project Volta

    Energy Technology Data Exchange (ETDEWEB)

    Vellone, R.; Di Mario, F.

    1987-09-01

    This paper discusses research and development in the field of fuel cell power plants. Reference is made to the Italian research Project Volta. Problems related to research program financing and fuel cell power plant marketing are discussed.

  9. 7 CFR 1230.635 - FSA State office report.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING.... Each FSA State office will transmit to the Administrator, FSA, a written summary of the results of the... on the referendum results contained in the reports from all county offices within each State and be...

  10. Pilot study with fly ash stabilised sewage sludge as hydraulic barrier layer; Pilotfoersoek med flygaskastabiliserat avloppsslam (FSA) som taetskikt

    Energy Technology Data Exchange (ETDEWEB)

    Macsik, Josef; Maurice, Christian; Mossakowska, Agnes; Eklund, Caroline

    2005-10-01

    A lot of landfills will be closed and finally covered during the next five to ten years. The design and construction of final closure caps, especially the landfill liner, are carried out to reduce the amount of water percolating through the landfill as to minimize the effect on the surrounding environment for a long time span. Earlier studies has indicated that sewage sludge stabilized with fly ash, resulting in a product called FSA, has a good potential to be used as landfill liner. In this project a large field test with FSA was carried out at a landfill under closure. The objective of the project was to study the following in depth: Manufacturing and construction regarding mainly technical and economical aspects; Permeability, stability and settlement as well as leachability; Durability, a key aspect. Environmental authorities advice that a closure cap shall guarantee function for several hundreds of years. The field tests were conducted at the landfill Dragmossen which is located south of Aelvkarleby in Sweden. During the field test approximately 1,500 tonnes FSA was manufactured. The FSA liner was installed on an area of 2,400 m{sup 2} with a thickness of 0,55 m. Parallel to the ongoing investigations at the landfill, laboratory studies were carried out to study the rate of biological decomposition of the liner. The results show that the manufactured FSA can be used as landfill liner in a large scale. The homogeneous quality, strength and low permeability of FSA is even better than the set criteria. The demands on the contained materials, fly ash and sewage sludge, are high and have to fulfil certain quality requirements for example regarding the water and dry solid content. The field test also showed that it is feasible to store fly ash and sewage sludge during at least two weeks to enable manufacturing in a larger scale. Mixing fly ash and sewage sludge will result in an odour due to bad smell and exit of ammonium gases. The odour fades away quickly after

  11. 33 CFR 105.305 - Facility Security Assessment (FSA) requirements.

    Science.gov (United States)

    2010-07-01

    ... evacuation routes and assembly stations; and (viii) Existing security and safety equipment for protection of... protection systems; (iv) Procedural policies; (v) Radio and telecommunication systems, including computer... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Facility Security Assessment (FSA...

  12. 7 CFR 782.12 - Filing FSA-750, End-Use Certificate for Wheat.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Filing FSA-750, End-Use Certificate for Wheat. 782.12... Certificate Program § 782.12 Filing FSA-750, End-Use Certificate for Wheat. (a) Each entity that imports wheat originating in Canada shall, for each entry into the U.S., obtain form FSA-750, End-Use Certificate for Wheat...

  13. A new FSA approach for in situ γ ray spectroscopy

    International Nuclear Information System (INIS)

    Caciolli, A.; Baldoncini, M.; Bezzon, G.P.; Broggini, C.; Buso, G.P.; Callegari, I.; Colonna, T.; Fiorentini, G.; Guastaldi, E.; Mantovani, F.; Massa, G.; Menegazzo, R.; Mou, L.; Alvarez, C. Rossi

    2012-01-01

    An increasing demand of environmental radioactivity monitoring comes both from the scientific community and from the society. This requires accurate, reliable and fast response preferably from portable radiation detectors. Thanks to recent improvements in the technology, γ spectroscopy with sodium iodide scintillators has been proved to be an excellent tool for in-situ measurements for the identification and quantitative determination of γ ray emitting radioisotopes, reducing time and costs. Both for geological and civil purposes not only 40 K, 238 U, and 232 Th have to be measured, but there is also a growing interest to determine the abundances of anthropic elements, like 137 Cs and 131 I, which are used to monitor the effect of nuclear accidents or other human activities. The Full Spectrum Analysis (FSA) approach has been chosen to analyze the γ spectra. The Non Negative Least Square (NNLS) and the energy calibration adjustment have been implemented in this method for the first time in order to correct the intrinsic problem related with the χ 2 minimization which could lead to artifacts and non physical results in the analysis. A new calibration procedure has been developed for the FSA method by using in situ γ spectra instead of calibration pad spectra. Finally, the new method has been validated by acquiring γ spectra with a 10.16 cm × 10.16 cm sodium iodide detector in 80 different sites in the Ombrone basin, in Tuscany. The results from the FSA method have been compared with the laboratory measurements by using HPGe detectors on soil samples collected particular, the 137 Cs isotopes has been implemented in the analysis since it has been found not negligible during the in-situ measurements. - Highlights: ► The Full Spectrum Analysis technique is investigated with sodium iodide scintillator. ► Artifacts due to the free chi 2 minimization in standard FSA are solved applying the NNLS. ► New calibration approach has been developed without using

  14. Summary of flat-plate solar array project documentation: Abstracts of published documents, 1975-1986, revision 1

    Science.gov (United States)

    Phillips, M. J.

    1986-01-01

    Abstracts of final reports, or the latest quarterly or annual, of the Flat-Plate Solar Array (FSA) Project Contractor of Jet Propulsion Laboratory (JPL) in-house activities are presented. Also presented is a list of proceedings and publications, by author, of work connected with the project. The aim of the program has been to stimulate the development of technology that will enable the private sector to manufacture and widely use photovoltaic systems for the generation of electricity in residential, commercial, industrial, and Government applications at a cost per watt that is competitive with utility generated power. FSA Project activities have included the sponsoring of research and development efforts in silicon refinement processes, advanced silicon sheet growth techniques, higher efficiency solar cells, solar cell/module fabrication processes, encapsulation, module/array engineering and reliability, and economic analyses.

  15. Flat-plate solar array project. Volume 7: Module encapsulation

    Science.gov (United States)

    Cuddihy, E.; Coulbert, C.; Gupta, A.; Liang, R.

    1986-01-01

    The objective of the Encapsulation Task was to develop, demonstrate, and qualify photovoltaic (PV) module encapsulation systems that would provide 20 year (later decreased to 30 year) life expectancies in terrestrial environments, and which would be compatible with the cost and performance goals of the Flat-Plate Solar Array (FSA) Project. The scope of the Encapsulation Task included the identification, development, and evaluation of material systems and configurations required to support and protect the optically and electrically active solar cell circuit components in the PV module operating environment. Encapsulation material technologies summarized include the development of low cost ultraviolet protection techniques, stable low cost pottants, soiling resistant coatings, electrical isolation criteria, processes for optimum interface bonding, and analytical and experimental tools for evaluating the long term durability and structural adequacy of encapsulated modules. Field testing, accelerated stress testing, and design studies have demonstrated that encapsulation materials, processes, and configurations are available that meet the FSA cost and performance goals.

  16. Navy fuel cell demonstration project.

    Energy Technology Data Exchange (ETDEWEB)

    Black, Billy D.; Akhil, Abbas Ali

    2008-08-01

    This is the final report on a field evaluation by the Department of the Navy of twenty 5-kW PEM fuel cells carried out during 2004 and 2005 at five Navy sites located in New York, California, and Hawaii. The key objective of the effort was to obtain an engineering assessment of their military applications. Particular issues of interest were fuel cell cost, performance, reliability, and the readiness of commercial fuel cells for use as a standalone (grid-independent) power option. Two corollary objectives of the demonstration were to promote technological advances and to improve fuel performance and reliability. From a cost perspective, the capital cost of PEM fuel cells at this stage of their development is high compared to other power generation technologies. Sandia National Laboratories technical recommendation to the Navy is to remain involved in evaluating successive generations of this technology, particularly in locations with greater environmental extremes, and it encourages their increased use by the Navy.

  17. Maritime Fuel Cell Generator Project.

    Energy Technology Data Exchange (ETDEWEB)

    Pratt, Joseph William [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2017-07-01

    Fuel costs and emissions in maritime ports are an opportunity for transportation energy efficiency improvement and emissions reduction efforts. Ocean-going vessels, harbor craft, and cargo handling equipment are still major contributors to air pollution in and around ports. Diesel engine costs continually increase as tighter criteria pollutant regulations come into effect and will continue to do so with expected introduction of carbon emission regulations. Diesel fuel costs will also continue to rise as requirements for cleaner fuels are imposed. Both aspects will increase the cost of diesel-based power generation on the vessel and on shore. Although fuel cells have been used in many successful applications, they have not been technically or commercially validated in the port environment. One opportunity to do so was identified in Honolulu Harbor at the Young Brothers Ltd. wharf. At this facility, barges sail regularly to and from neighbor islands and containerized diesel generators provide power for the reefers while on the dock and on the barge during transport, nearly always at part load. Due to inherent efficiency characteristics of fuel cells and diesel generators, switching to a hydrogen fuel cell power generator was found to have potential emissions and cost savings.

  18. 76 FR 14370 - Information Collection; Representation for CCC and FSA Loans Authorization To File a Financing...

    Science.gov (United States)

    2011-03-16

    ...; Representation for CCC and FSA Loans Authorization To File a Financing Statement AGENCY: Commodity Credit... Commodity Credit Corporation or Farm Service Agency Loans and Authorization To File A Financing Statement... Financing Statement and Related Documents. OMB Control Number: 0560-0215. Expiration Date of Approval...

  19. USGS public distribution of FSA 10:1 NAIP Imagery Downloadable Data Collection from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set collection contains imagery from the National Agriculture Imagery Program (NAIP). The NAIP program is administered by USDA FSA and has been established...

  20. A FSA Model for Performance Evaluation over Mobile Ad Hoc Networks with Low Traffic Volume

    Directory of Open Access Journals (Sweden)

    Heng LUO

    2014-07-01

    Full Text Available A Mobile Ad hoc network (MANET, which is composed of nodes that are able to move arbitrarily, differs from a direct connection network in the way that it is multi-hopping and self- organizing and thus able to operate without the help of prefixed infrastructures. However, problems such as unfavorable wireless links and dynamic topology are challenging, resulting in the proposal of a collection of routing protocols for MANETs. Nevertheless the performance of protocols may deteriorate dramatically as deployment scenario changes due to the application dependent philosophy behind algorithms. In this paper, the performance evaluation problem for MANETs and is explored and a novel performance ranking model, termed FSA, is proposed. For simplicity but without loss of generality, the performance of two routing protocols DSDV and DSR are studies. The FSA is able to rank the performance of DSDV and DSR depending on the average value and standard deviation results. Extensive simulations show that an overall 20.74 %, at most, gain may be achieved based on the FSA model.

  1. On a systematic perspective on risk for formal safety assessment (FSA)

    International Nuclear Information System (INIS)

    Montewka, Jakub; Goerlandt, Floris; Kujala, Pentti

    2014-01-01

    In the maritime domain, risk is evaluated within the framework of the Formal Safety Assessment (FSA), introduced by the International Maritime Organization in 2002. Although the FSA has become an internationally recognized and recommended method, the definition, which is adopted there, to describe the risk, seems to be too narrow to reflect the actual content of the FSA. Therefore this article discusses methodological requirements for the risk perspective, which is appropriate for risk management in the maritime domain with special attention to maritime transportation systems. A perspective that is proposed here considers risk as a set encompassing the following: a set of plausible scenarios leading to an accident, the likelihoods of unwanted events within the scenarios, the consequences of the events and description of uncertainty. All these elements are conditional upon the available knowledge (K) about the analyzed system and understanding (N) of the system behavior. Therefore, the quality of K and the level of N of a risk model should be reflected in the uncertainty description. For this purpose we introduce a qualitative scoring system, and we show its applicability on an exemplary risk model for a RoPax ship. - Highlights: • We present a risk perspective for the maritime domain. • A distinction between knowledge and understanding is made. • We describe risk as (Scenario, Consequences, Uncertainty/Knowledge, Understanding). • The perspective highlights the strength and weaknesses of a given risk analysis

  2. American fuel cell bus project : first analysis report.

    Science.gov (United States)

    2013-06-01

    This report summarizes the experience and early results from the American Fuel Cell Bus Project, a fuel cell electric bus demonstration : funded by the Federal Transit Administration (FTA) under the National Fuel Cell Bus Program. A team led by CALST...

  3. Validation of the FSA nutrient profiling system dietary index in French adults-findings from SUVIMAX study.

    Science.gov (United States)

    Julia, Chantal; Méjean, Caroline; Touvier, Mathilde; Péneau, Sandrine; Lassale, Camille; Ducrot, Pauline; Hercberg, Serge; Kesse-Guyot, Emmanuelle

    2016-08-01

    Population-wide nutritional recommendations give guidance on food groups' consumption, though a wide variability in nutritional quality within groups may subsist. Nutrient profiling systems may help capturing such variability. We aimed to apply and validate a dietary index based on the British Food Standards Agency nutrient profiling system (FSA-NPS DI) in French middle-aged adults. Dietary data were collected through repeated 24-h dietary records in participants of the Supplémentation en Vitamines et Minéraux Antioxydants study (N = 5882). An aggregated dietary index at the individual level was computed using the FSA-NPS for each food consumed as well as compliance to the French nutritional guidelines using the Programme National Nutrition Santé-Guideline Score (PNNS-GS). Cross-sectional associations between FSA-NPS DI and nutrient intake, PNNS-GS, socio-demographic factors, lifestyle and nutritional biomarkers were computed using ANOVAs. The FSA-NPS DI was able to characterize the quality of the diets at the individual level in terms of nutrient intake and of adherence to nutritional recommendations: +37.6 % in beta-carotene intakes between subjects with a healthier diet versus subjects with a poorer diet, +42.8 % in vitamin C intakes; +17 % in PNNS-GS, all P < 0.001. FSA-NPS-DI was also associated with nutritional status at the biological level: +21.4 % in beta-carotene levels between subjects with a healthier diet versus subjects with a poorer diet, +12.8 % in vitamin C levels, all P < 0.001. The FSA-NPS DI is a useful and validated tool to discriminate individuals according to the quality of the diet, accounting for nutritional quality within food groups. Taking into account nutritional quality of individual foods allows monitoring change in dietary patterns beyond food groups.

  4. Operations and Maintenance Manual for Full-Scale Bioventing System at FSA-1, Air Force Plant 4, Fort Worth, Texas

    National Research Council Canada - National Science Library

    1996-01-01

    This Operations and Maintenance (O&M) Manual has been created as a guide for monitoring and maintaining the performance of the full-scale bioventing blower system and vent well plumbing at FSA-1 at Air Force Plant 4 (AFP4), Texas...

  5. 29 CFR 458.38 - Deprivation of rights under the CSRA or FSA by violence or threat of violence.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Deprivation of rights under the CSRA or FSA by violence or threat of violence. 458.38 Section 458.38 Labor Regulations Relating to Labor OFFICE OF LABOR-MANAGEMENT... by violence or threat of violence. No labor organization or any officer, agent, shop steward, or...

  6. Formal Safety Assessment (FSA for Analysis of Ship Collision Using AIS Data

    Directory of Open Access Journals (Sweden)

    Muhammad Badrus Zaman

    2015-03-01

    Full Text Available Currently, Maritime safety is the best issue in the world. International Maritime organization (IMO have recommended FSA methodology to enhance maritime safety. In this paper, the research conducted in the Malacca Strait. Malacca Strait is an area that has a high risk for shipping navigation. Many accidents occur in the area are like collision, fire, grounding and so on. Therefore a study on improving safety in this area is very important. it is to produce an output that can be used to provide input to the master and multiple stakeholders to improve safety on board at the time of sailing. In this study, AIS is used as a data source. Sea condition data collected actual traffic through the Automatic Identification System (AIS equipment installed at Kobe University, Japan, and Universiti Teknologi Malaysia (UTM in Johor, Malaysia. The data is applied to define a method with the help of Geographic Information Systems (GIS.

  7. Fuel Cell Car Design Project for Freshman Engineering Courses

    Science.gov (United States)

    Duke, Steve R.; Davis, Virginia A.

    2014-01-01

    In the Samuel Ginn College of Engineering at Auburn University, we have integrated a semester long design project based on a toy fuel cell car into our freshman "Introduction to Chemical Engineering Class." The project provides the students a basic foundation in chemical reactions, energy, and dimensional analysis that facilitates…

  8. Framework of Sustainability Assessment (FSA) method for manufacturing industry in Malaysia

    Science.gov (United States)

    Soliha Sahimi, Nur; Turan, Faiz Mohd; Johan, Kartina

    2018-04-01

    In recent years, our planet faced massive social, environmental and economic challenges. Moreover, Environmental Democracy Index (EDI) published that Malaysia has been ranked as the second worst environmental democracy among 70 countries in May 2015. This is due to lack of participation in sustainability compliance and less awareness on sustainability by Malaysia’s business partners. By combating and achieving these, the Sustainable Development Goals (SDGs) defines global priorities and inspirations through Agenda 2030 that recognize by United Nation. This paper attempts to propose Framework Sustainability Assessment (FSA) to assess sustainability for the various sector in Malaysia. This framework will give an overview to reduce the noise from wide data collection to a single element. Lastly, it will integrate the current performance with the linkage of the SDGs and the sustainability elements by dividing into three phase which is baselining, clustering and correlation. Now it is time for business to take action especially every sector or industry in Malaysia and it will improve the awareness and enhance Environmental Democracy Index to a better rank in future.

  9. Project analysis and integration economic analyses summary

    Science.gov (United States)

    Macomber, H. L.

    1986-01-01

    An economic-analysis summary was presented for the manufacture of crystalline-silicon modules involving silicon ingot/sheet, growth, slicing, cell manufacture, and module assembly. Economic analyses provided: useful quantitative aspects for complex decision-making to the Flat-plate Solar Array (FSA) Project; yardsticks for design and performance to industry; and demonstration of how to evaluate and understand the worth of research and development both to JPL and other government agencies and programs. It was concluded that future research and development funds for photovoltaics must be provided by the Federal Government because the solar industry today does not reap enough profits from its present-day sales of photovoltaic equipment.

  10. The pore of the leaf cavity of Azolla species: teat cell differentiation and cell wall projections.

    Science.gov (United States)

    Veys, P; Lejeune, A; Van Hove, C

    2002-02-01

    The differentiation of the specialized secretory teat cells of the leaf cavity pore of Azolla species was investigated at the ultrastructural level with emphasis on their peculiar cell wall projections. The results indicated that the projections are formed as soon as the teat cells complete their differentiation and that their production is principally associated with changes in endoplasmic reticulum profiles. The number of projections increases with the teat cell age and is stimulated under salt and P deficiency stresses. Salt stress also promotes their emergence on Azolla species that under normal conditions do not produce projections. Cytochemical tests on different Azolla species showed that the projection composition is almost identical: proteins, acidic polysaccharides, and pectin are always detected. This study revealed that Azolla teat cell projections differ fundamentally from other types of hitherto described cell wall projections that are considered as remnant structures from cell separation. In contrast, in Azolla teat cells projections are actively produced and compounds are excreted by an exocytotic mechanism. The possible role of the projections in the symbiosis of Azolla spp. with Anabaena azollae is discussed.

  11. Flat-plate solar array project. Volume 3: Silicon sheet: Wafers and ribbons

    Science.gov (United States)

    Briglio, A.; Dumas, K.; Leipold, M.; Morrison, A.

    1986-01-01

    The primary objective of the Silicon Sheet Task of the Flat-Plate Solar Array (FSA) Project was the development of one or more low cost technologies for producing silicon sheet suitable for processing into cost-competitive solar cells. Silicon sheet refers to high purity crystalline silicon of size and thickness for fabrication into solar cells. Areas covered in the project were ingot growth and casting, wafering, ribbon growth, and other sheet technologies. The task made and fostered significant improvements in silicon sheet including processing of both ingot and ribbon technologies. An additional important outcome was the vastly improved understanding of the characteristics associated with high quality sheet, and the control of the parameters required for higher efficiency solar cells. Although significant sheet cost reductions were made, the technology advancements required to meet the task cost goals were not achieved.

  12. UMTRA project disposal cell cover biointrusion sensitivity assessment, Revision 1

    International Nuclear Information System (INIS)

    1995-10-01

    This study provides an analysis of potential changes that may take place in a Uranium Mill Tailings Remedial Action (UMTRA) Project disposal cell cover system as a result of plant biointrusion. Potential changes are evaluated by performing a sensitivity analysis of the relative impact of root penetrations on radon flux out of the cell cover and/or water infiltration into the cell cover. Data used in this analysis consist of existing information on vegetation growth on selected cell cover systems and information available from published studies and/or other available project research. Consistent with the scope of this paper, no new site-specific data were collected from UMTRA Project sites. Further, this paper does not focus on the issue of plant transport of radon gas or other contaminants out of the disposal cell cover though it is acknowledged that such transport has the potential to be a significant pathway for contaminants to reach the environment during portions of the design life of a disposal cell where plant growth occurs. Rather, this study was performed to evaluate the effects of physical penetration and soil drying caused by plant roots that have and are expected to continue to grow in UMTRA Project disposal cell covers. An understanding of the biological and related physical processes that take place within the cover systems of the UMTRA Project disposal cells helps the U.S. Department of Energy (DOE) determine if the presence of a plant community on these cells is detrimental, beneficial, or of mixed value in terms of the cover system's designed function. Results of this investigation provide information relevant to the formulation of a vegetation control policy

  13. Dorsal raphe nucleus projecting retinal ganglion cells: Why Y cells?

    Science.gov (United States)

    Pickard, Gary E.; So, Kwok-Fai; Pu, Mingliang

    2015-01-01

    Retinal ganglion Y (alpha) cells are found in retinas ranging from frogs to mice to primates. The highly conserved nature of the large, fast conducting retinal Y cell is a testament to its fundamental task, although precisely what this task is remained ill-defined. The recent discovery that Y-alpha retinal ganglion cells send axon collaterals to the serotonergic dorsal raphe nucleus (DRN) in addition to the lateral geniculate nucleus (LGN), medial interlaminar nucleus (MIN), pretectum and the superior colliculus (SC) has offered new insights into the important survival tasks performed by these cells with highly branched axons. We propose that in addition to its role in visual perception, the Y-alpha retinal ganglion cell provides concurrent signals via axon collaterals to the DRN, the major source of serotonergic afferents to the forebrain, to dramatically inhibit 5-HT activity during orientation or alerting/escape responses, which dis-facilitates ongoing tonic motor activity while dis-inhibiting sensory information processing throughout the visual system. The new data provide a fresh view of these evolutionarily old retinal ganglion cells. PMID:26363667

  14. American Fuel Cell Bus Project Evaluation. Second Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, Leslie [National Renewable Energy Lab. (NREL), Golden, CO (United States); Post, Matthew [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-09-01

    This report presents results of the American Fuel Cell Bus (AFCB) Project, a demonstration of fuel cell electric buses operating in the Coachella Valley area of California. The prototype AFCB was developed as part of the Federal Transit Administration's (FTA's) National Fuel Cell Bus Program. Through the non-profit consortia CALSTART, a team led by SunLine Transit Agency and BAE Systems developed a new fuel cell electric bus for demonstration. SunLine added two more AFCBs to its fleet in 2014 and another in 2015. FTA and the AFCB project team are collaborating with the U.S. Department of Energy (DOE) and DOE's National Renewable Energy Laboratory to evaluate the buses in revenue service. This report summarizes the performance results for the buses through June 2015.

  15. Solar Hydrogen Fuel Cell Projects at Brooklyn Tech

    Science.gov (United States)

    Fedotov, Alex; Farah, Shadia; Farley, Daithi; Ghani, Naureen; Kuo, Emmy; Aponte, Cecielo; Abrescia, Leo; Kwan, Laiyee; Khan, Ussamah; Khizner, Felix; Yam, Anthony; Sakeeb, Khan; Grey, Daniel; Anika, Zarin; Issa, Fouad; Boussayoud, Chayama; Abdeldayem, Mahmoud; Zhang, Alvin; Chen, Kelin; Chan, Kameron Chuen; Roytman, Viktor; Yee, Michael

    2010-01-01

    This article describes the projects on solar hydrogen powered vehicles using water as fuel conducted by teams at Brooklyn Technical High School. Their investigations into the pure and applied chemical thermodynamics of hydrogen fuel cells and bio-inspired devices have been consolidated in a new and emerging sub-discipline that they define as solar…

  16. 77 FR 5489 - Identification of Human Cell Lines Project

    Science.gov (United States)

    2012-02-03

    ... individual or species. With the advent of standardized, simple, and rapid methods for human cell line... project will undergo STR profiling, a DNA profiling method that examines/screens for STRs (DNA elements 2... distinct DNA profile and when the STR DNA fragment sizes are converted to numeric values, the DNA profiles...

  17. American Fuel Cell Bus Project Evaluation: Third Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, Leslie [National Renewable Energy Lab. (NREL), Golden, CO (United States); Post, Matthew [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jeffers, Matthew [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-05-01

    This report presents results of the American Fuel Cell Bus (AFCB) Project, a demonstration of fuel cell electric buses operating in the Coachella Valley area of California. The prototype AFCB, which was developed as part of the Federal Transit Administration's (FTA) National Fuel Cell Bus Program, was delivered to SunLine in November 2011 and was put in revenue service in mid-December 2011. Two new AFCBs with an upgraded design were delivered in June/July of 2014 and a third new AFCB was delivered in February 2015. FTA and the AFCB project team are collaborating with the U.S. Department of Energy (DOE) and DOE's National Renewable Energy Laboratory to evaluate the buses in revenue service. This report covers the performance of the AFCBs from July 2015 through December 2016.

  18. HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case.

    Science.gov (United States)

    Napolitano, José G; Lankin, David C; Graf, Tyler N; Friesen, J Brent; Chen, Shao-Nong; McAlpine, James B; Oberlies, Nicholas H; Pauli, Guido F

    2013-04-05

    This study demonstrates how regio- and diastereo-isomers with near-identical NMR spectra can be distinguished and unambiguously assigned using quantum mechanical driven (1)H iterative Full Spin Analysis (HiFSA). The method is illustrated with four natural products, the flavonolignans silybin A, silybin B, isosilybin A, and isosilybin B, which exhibit extremely similar coupling patterns and chemical shift differences well below the commonly reported level of accuracy of 0.01 ppm. The HiFSA approach generated highly reproducible (1)H NMR fingerprints that enable distinction of all four isomers at (1)H frequencies from 300 to 900 MHz. Furthermore, it is demonstrated that the underlying numeric (1)H NMR profiles, combined with iterative computational analysis, allow parallel quantification of all four isomers, even in difficult to characterize reference materials and mixtures. The results shed new light on the historical challenges to the qualitative and quantitative analysis of these therapeutically relevant flavonolignans and open new opportunities to explore hidden diversity in the chemical space of organic molecules.

  19. Fuel Cell Balance-of-Plant Reliability Testbed Project

    Energy Technology Data Exchange (ETDEWEB)

    Sproat, Vern [Stark State College of Technology, North Canton, OH (United States); LaHurd, Debbie [Lockheed Martin Corp., Oak Ridge, TN (United States)

    2016-10-29

    Reliability of the fuel cell system balance-of-plant (BoP) components is a critical factor that needs to be addressed prior to fuel cells becoming fully commercialized. Failure or performance degradation of BoP components has been identified as a life-limiting factor in fuel cell systems.1 The goal of this project is to develop a series of test beds that will test system components such as pumps, valves, sensors, fittings, etc., under operating conditions anticipated in real Polymer Electrolyte Membrane (PEM) fuel cell systems. Results will be made generally available to begin removing reliability as a roadblock to the growth of the PEM fuel cell industry. Stark State College students participating in the project, in conjunction with their coursework, have been exposed to technical knowledge and training in the handling and maintenance of hydrogen, fuel cells and system components as well as component failure modes and mechanisms. Three test beds were constructed. Testing was completed on gas flow pumps, tubing, and pressure and temperature sensors and valves.

  20. Photovoltaic Test and Demonstration Project. [for solar cell power systems

    Science.gov (United States)

    Forestieri, A. F.; Brandhorst, H. W., Jr.; Deyo, J. N.

    1976-01-01

    The Photovoltaic Test and Demonstration Project was initiated by NASA in June, 1975, to develop economically feasible photovoltaic power systems suitable for a variety of terrestrial applications. Objectives include the determination of operating characteristic and lifetimes of a variety of solar cell systems and components and development of methodology and techniques for accurate measurements of solar cell and array performance and diagnostic measurements for solar power systems. Initial work will be concerned with residential applications, with testing of the first prototype system scheduled for June, 1976. An outdoor 10 kW array for testing solar power systems is under construction.

  1. 7 CFR Appendix C to Subpart C of... - FSA-2514, Notice of Availability of Loan Servicing to Borrowers Who Are in Non-Monetary Default

    Science.gov (United States)

    2010-01-01

    ... Borrowers Who Are in Non-Monetary Default C Appendix C to Subpart C of Part 766 Agriculture Regulations of... PROGRAMS DIRECT LOAN SERVICING-SPECIAL Loan Servicing Programs Pt. 766, Subpt. C, App. C Appendix C to Subpart C of Part 766—FSA-2514, Notice of Availability of Loan Servicing to Borrowers Who Are in Non...

  2. Diesel fueled ship propulsion fuel cell demonstration project

    Energy Technology Data Exchange (ETDEWEB)

    Kumm, W.H. [Arctic Energies Ltd., Severna Park, MD (United States)

    1996-12-31

    The paper describes the work underway to adapt a former US Navy diesel electric drive ship as a 2.4 Megawatt fuel cell powered, US Coast Guard operated, demonstrator. The Project will design the new configuration, and then remove the four 600 kW diesel electric generators and auxiliaries. It will design, build and install fourteen or more nominal 180 kW diesel fueled molten carbonate internal reforming direct fuel cells (DFCs). The USCG cutter VINDICATOR has been chosen. The adaptation will be carried out at the USCG shipyard at Curtis Bay, MD. A multi-agency (state and federal) cooperative project is now underway. The USCG prime contractor, AEL, is performing the work under a Phase III Small Business Innovation Research (SBIR) award. This follows their successful completion of Phases I and II under contract to the US Naval Sea Systems (NAVSEA) from 1989 through 1993 which successfully demonstrated the feasibility of diesel fueled DFCs. The demonstrated marine propulsion of a USCG cutter will lead to commercial, naval ship and submarine applications as well as on-land applications such as diesel fueled locomotives.

  3. Texas LPG fuel cell development and demonstration project

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2004-07-26

    The State Energy Conservation Office has executed its first Fuel Cell Project which was awarded under a Department of Energy competitive grant process. The Texas LPG Fuel Processor Development and Fuel Cell Demonstration Program is a broad-based public/private partnership led by the Texas State Energy Conservation Office (SECO). Partners include the Alternative Fuels Research and Education Division (AFRED) of the Railroad Commission of Texas; Plug Power, Inc., Latham, NY, UOP/HyRadix, Des Plaines, IL; Southwest Research Institute (SwRI), San Antonio, TX; the Texas Natural Resource Conservation Commission (TNRCC), and the Texas Department of Transportation (TxDOT). The team proposes to mount a development and demonstration program to field-test and evaluate markets for HyRadix's LPG fuel processor system integrated into Plug Power's residential-scale GenSys(TM) 5C (5 kW) PEM fuel cell system in a variety of building types and conditions of service. The program's primary goal is to develop, test, and install a prototype propane-fueled residential fuel cell power system supplied by Plug Power and HyRadix in Texas. The propane industry is currently funding development of an optimized propane fuel processor by project partner UOP/HyRadix through its national checkoff program, the Propane Education and Research Council (PERC). Following integration and independent verification of performance by Southwest Research Institute, Plug Power and HyRadix will produce a production-ready prototype unit for use in a field demonstration. The demonstration unit produced during this task will be delivered and installed at the Texas Department of Transportation's TransGuide headquarters in San Antonio, Texas. Simultaneously, the team will undertake a market study aimed at identifying and quantifying early-entry customers, technical and regulatory requirements, and other challenges and opportunities that need to be addressed in planning commercialization of the units

  4. Leading fuel cell projects ``PEM``; Brennstoffzellen-Leitprojekte ``PEM``

    Energy Technology Data Exchange (ETDEWEB)

    Isenberg, G

    1996-12-31

    Polymer electrolyte diaphragm fuel cells (PEMFC) are distinguished by high specific power densities which are necessary in the field of electrical drives, high efficiencies and no or very low emission of harmful substances, depending on the fuel. In the context of a leading project supported by BMBF, the development of improved and above all, more reasonably priced components for the PEMFC and the reforming of methanol is to work out the important technical basis for the subsequent economic conversion into a vehicle drive. (orig.) [Deutsch] Polymer-Elektrolyt-Membran-Brennstoffzellen (PEMFC) zeichnen sich durch hohe spezifische Leistungsdichten, wie sie im Bereich elektrischer Antriebe notwendig sind, hohe Wirkungsgrade und treibstoffabhaengig keine bzw. sehr niedrige Schadstoffemission aus. Im Rahmen eines BMBF-gefoerderten Leitprojekts sollen mit der Entwicklung verbesserter, vor allem kostenguenstiger Komponenten fuer die PEMFC und die Methanol-Reformierung wesentliche technologische Grundlagen fuer die anschliessende wirtschaftliche Umsetzung als Fahrzeugantrieb erarbeitet werden. (orig.)

  5. Fuel cell propulsion for urban duty vehicles: Bavarian fuel cell bus project

    International Nuclear Information System (INIS)

    Wurster, R.; Altmann, M.; Sillat, D.; Kalk, K. W.; Hammerschmidt, A.; Stuehler, W.; Holl, E.

    1998-01-01

    Following a feasibility study and a detailed specification phase, the realization of a fuel cell city bus prototype was started in autumn 1996. The project is a joint development effort of Siemens, MAN and Linde, which receives a 50 % funding by the Bavarian State Ministry for Economic Affairs, Transport and Technology (BStMWVT) in the context of the Hydrogen Initiative Bavaria. An MAN low-floor bus will be equipped with the components for a fuel cell drive system. The PEM fuel cell is developed by the power generation division of Siemens. Four fuel cell modules deliver a total electrical output of 120 kW to the two electric motors, which are linked by a summation gearbox by the Siemens Transportation Systems Division. MAN Technologie AG is responsible for the compressed hydrogen storage system allowing for a driving range of more than 250 km, while Linde AG takes care of the hydrogen periphery and delivers the hydrogen for the test operation scheduled for the beginning of the year 2000. Project coordination is done by Ludwig-Boelkow System-technik GmbH. The project is divided into four phases. The conceptual design phase is scheduled to last until the end of 1997. The partly overlapping system integration phase will end in the first quarter of 1999. The subsequent test and commissioning phase will prepare the test operation at the beginning of 2000 with a bus operator yet to be defined. (author)

  6. Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry.

    Science.gov (United States)

    Halpern, H J; Yu, C; Peric, M; Barth, E D; Karczmar, G S; River, J N; Grdina, D J; Teicher, B A

    1996-05-01

    We have used very low-frequency electron paramagnetic resonance (EPR) oximetry to measure the change in oxygen concentration (delta pO2) due to change in breathing atmosphere in FSa and NFSa fibrosarcomas implanted in the legs of C3H mice infused with perfluoro-octylbromine (PFOB). Measurements in each tumor were made before and after the administration of the high-density (47% v/v) perfluorocarbon PFOB, perflubron (Alliance Pharmaceutical Corporation, San Diego, CA). Measurements in each tumor were also made, after the administration of the PFOB, both before (PFOB/air) and after the administration of carbogen (95% O2 + 5% CO2, PFOB/carbogen). Large changes (delta p02) relative to PFOB/air oxygenation were seen with the administration of PFOB/carbogen. No significant difference in oxygen concentration was seen between air-breathing mice with and without PFOB. The mean delta pO2 for FSa tumors was 13 +/- 6 torr, while the mean for NFSa fibrosarcomas was 28 +/- 7 torr. There were such large intertumor differences that the trend toward a smaller change in the more hypoxic FSa tumors was not significant (P = 0.13). This paper describes a novel method of measuring differences in oxygenation in tumor tissues. The results of such measurements indicate large differences in pO2 response to different breathing atmospheres in PFOB-infused tumors of similar histology. The intertumor delta pO2 differences may correlate with differences in radiation response.

  7. Real-time Risk Assessment for Aids to Navigation Using Fuzzy-FSA on Three-Dimensional Simulation System

    Directory of Open Access Journals (Sweden)

    Jinbiao Chen

    2014-06-01

    Full Text Available The risk level of the Aids to Navigation (AtoNs can reflect the ship navigation safety level in the channel to some extent. In order to appreciate the risk level of the aids to navigation (AtoNs in a navigation channel and to provide some decision-making suggestions for the AtoNs Maintenance and Management Department, the risk assessment index system of the AtoNs was built considering the advanced experience of IALA. Under the Formal Safety Assessment frame, taking the advantages of the fuzzy comprehensive evaluation method, the fuzzy-FSA model of risk assessment for aids to navigation was established. The model was implemented for the assessment of aids to navigation in Shanghai area based on the aids to navigation three-dimensional simulation system. The real-time data were extracted from the existing information system of aids to navigation, and the real-time risk assessment for aids to navigation of the chosen channel was performed on platform of the three-dimensional simulation system, with the risk assessment software. Specifically, the deep-water channel of the Yangtze River estuary was taken as an example to illustrate the general assessment procedure. The method proposed presents practical significance and application prospect on the maintenance and management of the aids to navigation.

  8. Project Profile: Hydrogen Fuel Cell Mobile Lighting Tower (HFCML)

    Science.gov (United States)

    McLaughlin, Russell

    2013-01-01

    NASA is committed to finding innovative solutions that improve the operational performance of ground support equipment while providing environment and cost benefits, as well. Through the Hydrogen Fuel Cell Mobile Lighting Tower (HFCML) project, NASA gained operational exposure to a novel application of high efficiency technologies. Traditionally, outdoor lighting and auxiliary power at security gates, launch viewing sites, fallback areas, outage support, and special events is provided by diesel generators with metal halide lights. Diesel generators inherently contribute to C02, NOx, particulate emissions, and are very noisy. In 2010, engineers from NASA's Technology Evaluation for Environmental Risk Mitigation Principal Center (TEERM) introduced KSC operations to a novel technology for outdoor lighting needs. Developed by a team led by Sandia National Laboratory (SNL), the technology pairs a 5kW hydrogen fuel cell with robust high efficiency plasma lights in a towable trailer. Increased efficiency, in both the fuel cell power source and lighting load, yields longer run times between fueling operations while providing greater auxiliary power. Because of the unit's quiet operation and no exhaust fumes, it is capable of being used indoors and in emergency situations, and meets the needs of all other operational roles for metal halide/diesel generators. The only discharge is some water and warm air. Environmental benefits include elimination of diesel particulate emissions and estimated 73% greenhouse gas emissions savings when the hydrogen source is natural gas (per GREET model). As the technology matures the costs could become competitive for the fuel cell units which are approximately 5 times diesel units. Initial operational . concerns included the hydrogen storage tanks and valves, lightning safety/grounding, and required operating and refueling procedures. TEERM facilitated technical information exchange (design drawings, technical standards, and operations

  9. Process Intensification in Fuel Cell CHP Systems, the ReforCELL Project

    Directory of Open Access Journals (Sweden)

    José Luis Viviente

    2016-10-01

    Full Text Available This paper reports the findings of a FP7/FCH JU project (ReforCELL that developed materials (catalysts and membranes and an advance autothermal membrane reformer for a micro Combined Heat and Power (CHP system of 5 kWel based on a polymer electrolyte membrane fuel cell (PEMFC. In this project, an active, stable and selective catalyst was developed for the reactions of interest and its production was scaled up to kg scale (TRL5 (TRL: Technology Readiness Level. Simultaneously, new membranes for gas separation were developed. In particular, dense supported thin palladium-based membranes were developed for hydrogen separation from reactive mixtures. These membranes were successfully scaled up to TRL4 and used in lab-scale reactors for fluidized bed steam methane reforming (SMR and autothermal reforming (ATR and in a prototype reactor for ATR. Suitable sealing techniques able to integrate the different membranes in lab-scale and prototype reactors were also developed. The project also addressed the design and optimization of the subcomponents (BoP for the integration of the membrane reformer to the fuel cell system.

  10. Flat-plate solar array project. Volume 1: Executive summary

    Science.gov (United States)

    Callaghan, W.; Mcdonald, R.

    1986-01-01

    In 1975, the U.S. Government contracted the Jet Propulsion Lab. to develop, by 1985, in conjunction with industry, the photovoltaics (PV) module and array technology required for widespread use of photovoltaics as a significant terrestrial energy source. As a result, a project that eventually became known as the Flat Plate Solar Array (FSA) Project was formed to manage an industry, university, and Government team to perform the necessary research and development. The original goals were to achieve widespread commercial use of PV modules and arrays through the development of technology that would allow them to be profitably sold for $1.07/peak watts (1985 dollars). A 10% module conversion efficiency and a 20 year lifetime were also goals. It is intended that the executive summary provide the means by which one can gain a perspective on 11 years of terrestrial photovoltaic research and development conducted by the FSA Project.

  11. The logic of single-cell projections from visual cortex.

    Science.gov (United States)

    Han, Yunyun; Kebschull, Justus M; Campbell, Robert A A; Cowan, Devon; Imhof, Fabia; Zador, Anthony M; Mrsic-Flogel, Thomas D

    2018-04-05

    Neocortical areas communicate through extensive axonal projections, but the logic of information transfer remains poorly understood, because the projections of individual neurons have not been systematically characterized. It is not known whether individual neurons send projections only to single cortical areas or distribute signals across multiple targets. Here we determine the projection patterns of 591 individual neurons in the mouse primary visual cortex using whole-brain fluorescence-based axonal tracing and high-throughput DNA sequencing of genetically barcoded neurons (MAPseq). Projections were highly diverse and divergent, collectively targeting at least 18 cortical and subcortical areas. Most neurons targeted multiple cortical areas, often in non-random combinations, suggesting that sub-classes of intracortical projection neurons exist. Our results indicate that the dominant mode of intracortical information transfer is not based on 'one neuron-one target area' mapping. Instead, signals carried by individual cortical neurons are shared across subsets of target areas, and thus concurrently contribute to multiple functional pathways.

  12. Connecticut nutmeg fuel cell bus project : first analysis report.

    Science.gov (United States)

    2012-07-01

    This report summarizes the experience and early results from a fuel cell bus demonstration funded by the Federal Transit Administra-tion (FTA) under the National Fuel Cell Bus Program (NFCBP). A team led by the Northeast Advanced Vehicle Consortium a...

  13. Using cell phones to improve language skills: the Hadeda project

    CSIR Research Space (South Africa)

    Butgereit, L

    2009-12-01

    Full Text Available is required for tertiary education. Unfortunately, cell phones are often blamed for the degradation of language skills. There have been many studies blaming cell phone usage and instant messaging as being responsible for the lack of language skills of children...

  14. Using Cell Phones to Improve Language Skills: The Hadeda Project

    Science.gov (United States)

    Butgereit, Laurie; Botha, Adele; van Niekerk, Daniel

    Language skills are essential for education and economic development. Many countries (especially in Africa) have more than one official language and even more unofficial languages. Being able to express oneself effectively in the written word is required for tertiary education. Unfortunately, cell phones are often blamed for the degradation of language skills. There have been many studies blaming cell phone usage and instant messaging as being responsible for the the lack of language skills of children, teenagers, and young adults. Hadeda is a facility where teachers and parents can create spelling lists for pupils and children using either a cell phone or an internet based workstation. Hadeda then generates a fun and enjoyable cell phone midlet (computer program) which pupils and children can download onto their personal cell phone. Hadeda pronounces the words with electronic voices and the pupils and children can then practice their spelling on a medium they enjoy.

  15. Learning Cell Biology as a Team: A Project-Based Approach to Upper-Division Cell Biology

    Science.gov (United States)

    Wright, Robin; Boggs, James

    2002-01-01

    To help students develop successful strategies for learning how to learn and communicate complex information in cell biology, we developed a quarter-long cell biology class based on team projects. Each team researches a particular human disease and presents information about the cellular structure or process affected by the disease, the cellular…

  16. BIPM project: Intercomparison of water triple-point cells

    Science.gov (United States)

    Chattle, M. V.; Butler, J.

    1994-12-01

    The paper presents the results of an intercomparison between 3 triple point of water cells circulated by the Bureau International des Poids et Measures (BIPM), and a cell which is one of those used as a reference cell at the National Physical Laboratory (NPL). All 4 cells were prepared, stored and measured in the manner normally adopted at NPL. The results of the intercomparison show that over the course of about 6 weeks the temperatures of the 3 circulated cells generally agreed within 0.20 mK, with a maximum difference of 0.27(7) mK. Over the same period, the total variations of temperature measured in the 3 individual cells were 0.04 mK, 0.08 mK and 0.18 mK, respectively; the NPL cell varied by 0.10 mK. Gallium point measurements made over a similar period confirmed that these differences were partly due to small drifts in the thermometer resistance or in the measuring system.

  17. Massachusetts Fuel Cell Bus Project: Demonstrating a Total Transit Solution for Fuel Cell Electric Buses in Boston

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-22

    The Federal Transit Administration's National Fuel Cell Bus Program focuses on developing commercially viable fuel cell bus technologies. Nuvera is leading the Massachusetts Fuel Cell Bus project to demonstrate a complete transit solution for fuel cell electric buses that includes one bus and an on-site hydrogen generation station for the Massachusetts Bay Transportation Authority (MBTA). A team consisting of ElDorado National, BAE Systems, and Ballard Power Systems built the fuel cell electric bus, and Nuvera is providing its PowerTap on-site hydrogen generator to provide fuel for the bus.

  18. Scientific projection paper for mutagenesis, transformation and cell killing

    International Nuclear Information System (INIS)

    Todd, P.

    1980-01-01

    Our knowledge about mutagenesis, transformation, and cell killing by ionizing radiation consists of large bodies of data, which are potentially useful in terms of application to human risk assessment and to the constructive use of radiation, as in cancer treatment. The three end-points discussed above are united by at least five significant concepts in radiation research strategy: (1) The inter-relationships among the important end-points, mutation, carcinogenesis, and cell killing. Research on one is meaningful only in the context of information about the other two. (2) The interaction of radiations with other agents in producing these end-points. (3) The mechanisms of action of other environmental mutagenic, carcinogenic, and cytotoxic agents. (4) The use of repair deficient human mutant cells. (5) The study of radiation damage mechanisms. There is no better way to extrapolate laboratory data to the clinical and public worlds than to understand the underlying biological mechanisms that produced the data

  19. Energizing Engineering Students with Hydrogen Fuel Cell Project

    Science.gov (United States)

    Cannell, Nori; Zavaleta, Dan

    2010-01-01

    At Desert Vista High School, near Phoenix, Arizona, Perkins Innovation Grant funding is being used to fund a program that is helping to prepare students for careers in engineering by giving them hands-on experience in areas like hydrogen generation and fuel cell utilization. As one enters Dan Zavaleta's automotive and engineering classroom and lab…

  20. Final Project Closeout Report for Sprint Hydrogen Fuel Cell (HFC) Deployment Project in California, Gulf Coast and Eastern Seaboard Markets

    Energy Technology Data Exchange (ETDEWEB)

    Kenny, Kevin [Sprint, Reston, VA (United States); Bradley, Dwayne [Burns & McDonnell, Kansas City, MO (United States)

    2015-09-01

    Sprint is one of the telecommunications industry leaders in the deployment of hydrogen fuel cell (HFC) systems to provide backup power for their mission critical wireless network facilities. With several hundred fuel cells commissioned in California, states in the gulf coast region, and along the upper eastern seaboard. A strong incentive for advancing the integration of fuel cells into the Sprint network came through the award of a Department of Energy (DOE) grant focused on Market Transformation activities for project (EE0000486). This grant was funded by the 2009 American Recovery and Reinvestment Act (ARRA). The funding provided by DOE ($7.295M) was allocated to support the installation of 260 new HFC systems, equipped with an on-site refillable Medium Pressure Hydrogen Storage Solution (MPHSS), as well as for the conversion of 21 low pressure hydrogen systems to the MPHSS, in hopes of reducing barriers to market acceptance.

  1. Multiweek Cell Culture Project for Use in Upper-Level Biology Laboratories

    Science.gov (United States)

    Marion, Rebecca E.; Gardner, Grant E.; Parks, Lisa D.

    2012-01-01

    This article describes a laboratory protocol for a multiweek project piloted in a new upper-level biology laboratory (BIO 426) using cell culture techniques. Human embryonic kidney-293 cells were used, and several culture media and supplements were identified for students to design their own experiments. Treatments included amino acids, EGF,…

  2. BC Transit Fuel Cell Bus Project: Evaluation Results Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Post, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-02-01

    This report evaluates a fuel cell electric bus demonstration led by British Columbia Transit (BC Transit) in Whistler, Canada. BC Transit is collaborating with the California Air Resources Board and the U.S. Department of Energy's National Renewable Energy Laboratory to evaluate the buses in revenue service. This evaluation report covers two years of revenue service data on the buses from April 2011 through March 2013.

  3. Flat-plate solar array project. Volume 2: Silicon material

    Science.gov (United States)

    Lutwack, R.

    1986-10-01

    The goal of the Silicon Material Task, a part of the Flat Plate Solar Array (FSA) Project, was to develop and demonstate the technology for the low cost production of silicon of suitable purity to be used as the basic material for the manufacture of terrestrial photovoltaic solar cells. Summarized are 11 different processes for the production of silicon that were investigated and developed to varying extent by industrial, university, and Government researchers. The silane production section of the Union Carbide Corp. (UCC) silane process was developed completely in this program. Coupled with Siemens-type chemical vapor deposition reactors, the process was carried through the pilot stage. The overall UCC process involves the conversion of metallurgical-grade silicon to silane followed by decomposition of the silane to purified silicon. The other process developments are described to varying extents. Studies are reported on the effects of impurities in silicon on both silicon-material properties and on solar cell performance. These studies on the effects of impurities yielded extensive information and models for relating specific elemental concentrations to levels of deleterious effects.

  4. Flat-plate solar array project. Volume 2: Silicon material

    Science.gov (United States)

    Lutwack, R.

    1986-01-01

    The goal of the Silicon Material Task, a part of the Flat Plate Solar Array (FSA) Project, was to develop and demonstate the technology for the low cost production of silicon of suitable purity to be used as the basic material for the manufacture of terrestrial photovoltaic solar cells. Summarized are 11 different processes for the production of silicon that were investigated and developed to varying extent by industrial, university, and Government researchers. The silane production section of the Union Carbide Corp. (UCC) silane process was developed completely in this program. Coupled with Siemens-type chemical vapor deposition reactors, the process was carried through the pilot stage. The overall UCC process involves the conversion of metallurgical-grade silicon to silane followed by decomposition of the silane to purified silicon. The other process developments are described to varying extents. Studies are reported on the effects of impurities in silicon on both silicon-material properties and on solar cell performance. These studies on the effects of impurities yielded extensive information and models for relating specific elemental concentrations to levels of deleterious effects.

  5. BC Transit Fuel Cell Bus Project Evaluation Results: Second Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L.; Post, M.

    2014-09-01

    Second report evaluating a fuel cell electric bus (FCEB) demonstration led by British Columbia Transit (BC Transit) in Whistler, Canada. BC Transit is collaborating with the California Air Resources Board and the U.S. Department of Energy's National Renewable Energy Laboratory to evaluate the buses in revenue service. NREL published its first report on the demonstration in February 2014. This report is an update to the previous report; it covers 3 full years of revenue service data on the buses from April 2011 through March 2014 and focuses on the final experiences and lessons learned.

  6. Financial investments in fuel cells and hydrogen projects in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Brito de Matos, Maiana; Neves, Newton Pimenta Jr.; Silva, Ennio Peres da; Silva Pinto, Cristiano [Universidade Estadual de Campinas (UNICAMP), SP (Brazil)

    2010-07-01

    This work aims to identify, classify and account for the investments in hydrogen and fuel cells from 1999 to 2007 made by the public and private sectors in Brazil. Two methodologies were applied to obtain the data for this study. The Top-Down methodology was used to obtain the information from the sponsoring agencies, institutions and funds that promote science and technology in Brazil, such as CNPq, FINEP, P and D ANEEL and Regional Foundations for Research Support. The Bottom-Up methodology consisted in obtaining data directly from the research groups granted by those agencies. After accounting the total Brazilian investment in the period, this was compared with the investments made by the other BRIC countries (Russia, India and China). Next, BRIC countries investment was compared with those made by the European Union, Japan and the United States. The results show that in order to participate in the market share related to equipment and services for the hydrogen economy, Brazil needs to increase the efforts in research, development and innovation in the area. It will be also necessary to apply resources in other important research issues besides ethanol reforming, polymer electrolyte and solid oxide fuel cells, which are the current technologies supported by the Brazilian funding agencies. To achieve this, resources that are already available could be used more efficiently. Another important evidence is that the total annual investment made BRIC countries together is of the same order of magnitude as the investments made separately by the European Union, Japan and the United States. (orig.)

  7. Adaptive function projective synchronization of two-cell Quantum-CNN chaotic oscillators with uncertain parameters

    International Nuclear Information System (INIS)

    Sudheer, K. Sebastian; Sabir, M.

    2009-01-01

    This work investigates function projective synchronization of two-cell Quantum-CNN chaotic oscillators using adaptive method. Quantum-CNN oscillators produce nano scale chaotic oscillations under certain conditions. By Lyapunove stability theory, the adaptive control law and the parameter update law are derived to make the state of two chaotic systems function projective synchronized. Numerical simulations are presented to demonstrate the effectiveness of the proposed adaptive controllers.

  8. Projectables

    DEFF Research Database (Denmark)

    Rasmussen, Troels A.; Merritt, Timothy R.

    2017-01-01

    CNC cutting machines have become essential tools for designers and architects enabling rapid prototyping, model-building and production of high quality components. Designers often cut from new materials, discarding the irregularly shaped remains. We introduce ProjecTables, a visual augmented...... reality system for interactive packing of model parts onto sheet materials. ProjecTables enables designers to (re)use scrap materials for CNC cutting that would have been previously thrown away, at the same time supporting aesthetic choices related to wood grain, avoiding surface blemishes, and other...... relevant material properties. We conducted evaluations of ProjecTables with design students from Aarhus School of Architecture, demonstrating that participants could quickly and easily place and orient model parts reducing material waste. Contextual interviews and ideation sessions led to a deeper...

  9. Differential Axonal Projection of Mitral and Tufted Cells in the Mouse Main Olfactory System

    Directory of Open Access Journals (Sweden)

    Shin Nagayama

    2010-09-01

    Full Text Available In the past decade, much has been elucidated regarding the functional organization of the axonal connection of olfactory sensory neurons to olfactory bulb (OB glomeruli. However, the manner in which projection neurons of the OB process odorant input and send this information to higher brain centers remains unclear. Here, we report long-range, large-scale tracing of the axonal projection patterns of OB neurons using two-photon microscopy. Tracer injection into a single glomerulus demonstrated widely distributed mitral/tufted cell axonal projections on the lateroventral surface of the mouse brain, including the anterior/posterior piriform cortex (PC and olfactory tubercle (OT. We noted two distinct groups of labeled axons: PC-orienting axons and OT-orienting axons. Each group occupied distinct parts of the lateral olfactory tract. PC-orienting axons projected axon collaterals to a wide area of the PC but only a few collaterals to the OT. OT-orienting axons densely projected axon collaterals primarily to the anterolateral OT (alOT. Different colored dye injections into the superficial and deep portions of the OB external plexiform layer revealed that the PC-orienting axon populations originated in presumed mitral cells and the OT-orienting axons in presumed tufted cells. These data suggest that although mitral and tufted cells receive similar odor signals from a shared glomerulus, they process the odor information in different ways and send their output to different higher brain centers via the PC and alOT.

  10. Hydrogen fueling stations in Japan hydrogen and fuel cell demonstration project

    International Nuclear Information System (INIS)

    Koseki, K.; Tomuro, J.; Sato, H.; Maruyama, S.

    2004-01-01

    A new national demonstration project of fuel cell vehicles, which is called Japan Hydrogen and Fuel Cell Demonstration Project (JHFC Project), has started in FY2002 on a four-year plan. In this new project, ten hydrogen fueling stations have been constructed in Tokyo and Kanagawa area in FY2002-2003. The ten stations adopt the following different types of fuel and fueling methods: LPG reforming, methanol reforming, naphtha reforming, desulfurized-gasoline reforming, kerosene reforming, natural gas reforming, water electrolysis, liquid hydrogen, by-product hydrogen, and commercially available cylinder hydrogen. Approximately fifty fuel cell passenger cars and a fuel cell bus are running on public roads using these stations. In addition, two hydrogen stations will be constructed in FY2004 in Aichi prefecture where The 2005 World Exposition (EXPO 2005) will be held. The stations will service eight fuel cell buses used as pick-up buses for visitors. We, Engineering Advancement Association of Japan (ENAA), are commissioned to construct and operate a total of twelve stations by Ministry of Economy Trade and Industry (METI). We are executing to demonstrate or identify the energy-saving effect, reduction of the environmental footprint, and issues for facilitating the acceptance of hydrogen stations on the basis of the data obtained from the operation of the stations. (author)

  11. Organization of spinocerebellar projection map in three types of agranular cerebellum: Purkinje cells vs. granule cells as organizer element

    International Nuclear Information System (INIS)

    Arsenio Nunes, M.L.; Sotelo, C.; Wehrle, R.

    1988-01-01

    The organization of the spinocerebellar projection was analysed by the anterograde axonal WGA-HRP (horseradish peroxidase-wheat germ agglutinin conjugate) tracing method in three different types of agranular cerebellar cortex either induced experimentally by X-irradiation or occurring spontaneously in weaver (wv/wv) and staggerer (sg/sg) mutant mice. The results of this study show that in the X-irradiated rat and weaver mouse, in both of which the granule cells are directly affected and die early in development, the spinal axons reproduce, with few differences, the normal spinocerebellar pattern. Conversely, in staggerer mouse, in which the Purkinje cells are intrinsically affected and granule neurons do not seem to be primarily perturbed by the staggerer gene action, the spinocerebellar organization is severely modified. These findings appear somewhat paradoxical because if granule cells, the synaptic targets of mossy spinocerebellar fibers, were necessary for the organization of spinocerebellar projection, the staggerer cerebellum would exhibit a much more normal projectional map than the weaver and the X-irradiated cerebella. It is, therefore, obvious that granule cells, and even specific synaptogenesis, are not essential for the establishment of the normal spinocerebellar topography. On the other hand, the fact that the Purkinje cells are primarily affected in the unique agranular cortex in which the spinocerebellar organization is severely modified suggests that these neurons could be the main element in the organization of the spinocerebellar projection map. This hypothesis is discussed in correlation with already-reported findings on the zonation of the cerebellar cortex by biochemically different clusters of Purkinje cells

  12. Lithium Battery Safety/Cell-to-Cell Failure Project FY14 Progress Report

    Science.gov (United States)

    2015-03-06

    as the cell remained a closed system. In an actual application, cells lose heat to the ambient 31 environment and to expelled materials during...that specific heat was unchanged from that of the virgin cell. We fit three polynomial functions to the data shown in Figure 19, and these

  13. Nucleus retroambiguous projections to lumbosacral motoneuronal cell groups in the male cat

    NARCIS (Netherlands)

    Vanderhorst, VGJM; Holstege, G

    1997-01-01

    Recently, in the female cat, nucleus retroambiguus (NRA) projections have been described as distinct motoneuronal cell groups in the lumbar enlargement, possibly involved in lordosis behavior. The present study deals with the NRA-lumbosacral pathway in the male cat, Lumbosacral injections of wheat

  14. Experiences from Swedish demonstration projects with phosphoric acid fuel cells; Erfarenheter fraan svenska demonstrationsprojekt med fosforsyrabraensleceller

    Energy Technology Data Exchange (ETDEWEB)

    Carlsson, Per [Sycon Energikonsult AB, Stockholm (Sweden); Sarkoezi, Laszlo [Vattenfall Utveckling AB, Stockholm (Sweden)

    1999-10-01

    In Sweden, there are today two phosphoric acid fuel cells installed, one PC25A which have been in operation in more than 4 years, and one PC25C which have been in operation for two years. The aim with this project has been two compare operation characteristics, performance, and operation experiences for these two models.

  15. Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC

    DEFF Research Database (Denmark)

    Becker, Juergen C.; Stang, Andreas; zur Hausen, Axel

    2018-01-01

    Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its carcinogenesis may be either caused by the clonal integration of the Merkel cell polyomavirus into the host genome or by UV-induced mutations. Notably, virally-encoded oncoproteins and UV-induced mutations...... knowledge on epidemiology, biology and therapy of MCC as conclusion of the project 'Immune Modulating strategies for treatment of Merkel Cell Carcinoma', which was funded over a 5-year period by the European Commission to investigate innovative immunotherapies for MCC....

  16. Flat-plate solar array project. Volume 8: Project analysis and integration

    Science.gov (United States)

    Mcguire, P.; Henry, P.

    1986-01-01

    Project Analysis and Integration (PA&I) performed planning and integration activities to support management of the various Flat-Plate Solar Array (FSA) Project R&D activities. Technical and economic goals were established by PA&I for each R&D task within the project to coordinate the thrust toward the National Photovoltaic Program goals. A sophisticated computer modeling capability was developed to assess technical progress toward meeting the economic goals. These models included a manufacturing facility simulation, a photovoltaic power station simulation and a decision aid model incorporating uncertainty. This family of analysis tools was used to track the progress of the technology and to explore the effects of alternative technical paths. Numerous studies conducted by PA&I signaled the achievement of milestones or were the foundation of major FSA project and national program decisions. The most important PA&I activities during the project history are summarized. The PA&I planning function is discussed and how it relates to project direction and important analytical models developed by PA&I for its analytical and assessment activities are reviewed.

  17. Vegetation growth patterns on six rock-covered UMTRA Project disposal cells

    International Nuclear Information System (INIS)

    1992-02-01

    This study assessed vegetation growth patterns, the potential impacts of vegetation growth on disposal cell cover integrity, and possible measures that could be taken to monitor and/or control plant growth, where necessary, on six Uranium Mill Tailings Remedial Action (UMTRA) Project rock-covered disposal cells. A large-scale invasion of volunteer plants was observed on the Shiprock and Burrell disposal cells. Plant growth at the South Clive, Green River, and Tuba City disposal cells was sparse except for the south rock apron and south slope of the Tuba City disposal cell, where windblown sand had filled up part of the rock cover and plant growth was observed. The rock-covered topslope of the Collins Ranch disposal cell was intentionally covered with topsoil and vegetated. Plant roots growing on the disposal cells are changing the characteristics of the cover by drying out the radon barrier, encouraging the establishment of soil-building processes in the bedding and radon barrier layers, creating channels in the radon barrier, and facilitating ecological succession, which could lead to the establishment of additional deep-rooted plants on the disposal cells. If left unchecked, plant roots would reach the tailings at the Burrell and Collins Ranch disposal cells within a few years, likely resulting in the transport of contaminants out of the cells

  18. Collateral Projections Innervate the Mammillary Bodies and Retrosplenial Cortex: A New Category of Hippocampal Cells

    Science.gov (United States)

    O’Mara, Shane M.

    2018-01-01

    To understand the hippocampus, it is necessary to understand the subiculum. Unlike other hippocampal subfields, the subiculum projects to almost all distal hippocampal targets, highlighting its critical importance for external networks. The present studies, in male rats and mice, reveal a new category of dorsal subiculum neurons that innervate both the mammillary bodies (MBs) and the retrosplenial cortex (RSP). These bifurcating neurons comprise almost half of the hippocampal cells that project to RSP. The termination of these numerous collateral projections was visualized within the medial mammillary nucleus and the granular RSP (area 29). These collateral projections included subiculum efferents that cross to the contralateral MBs. Within the granular RSP, the collateral projections form a particularly dense plexus in deep Layer II and Layer III. This retrosplenial termination site colocalized with markers for VGluT2 and neurotensin. While efferents from the hippocampal CA fields standardly collateralize, subiculum projections often have only one target site. Consequently, the many collateral projections involving the RSP and the MBs present a relatively unusual pattern for the subiculum, which presumably relates to how both targets have complementary roles in spatial processing. Furthermore, along with the anterior thalamic nuclei, the MBs and RSP are key members of a memory circuit, which is usually described as both starting and finishing in the hippocampus. The present findings reveal how the hippocampus simultaneously engages different parts of this circuit, so forcing an important revision of this network. PMID:29527569

  19. Cation and anion dependence of stable geometries and stabilization energies of alkali metal cation complexes with FSA(-), FTA(-), and TFSA(-) anions: relationship with physicochemical properties of molten salts.

    Science.gov (United States)

    Tsuzuki, Seiji; Kubota, Keigo; Matsumoto, Hajime

    2013-12-19

    Stable geometries and stabilization energies (Eform) of the alkali metal complexes with bis(fluorosulfonyl)amide, (fluorosulfonyl)(trifluoromethylslufonyl)amide and bis(trifluoromethylsulfonyl)amide (FSA(-), FTA(-) and TFSA(-)) were studied by ab initio molecular orbital calculations. The FSA(-) complexes prefer the bidentate structures in which two oxygen atoms of two SO2 groups have contact with the metal cation. The FTA(-) and TFSA(-) complexes with Li(+) and Na(+) prefer the bidentate structures, while the FTA(-) and TFSA(-) complexes with Cs(+) prefer tridentate structures in which the metal cation has contact with two oxygen atoms of an SO2 group and one oxygen atom of another SO2 group. The two structures are nearly isoenergetic in the FTA(-) and TFSA(-) complexes with K(+) and Rb(+). The magnitude of Eform depends on the alkali metal cation significantly. The Eform calculated for the most stable TFSA(-) complexes with Li(+), Na(+), K(+), Rb(+) and Cs(+) cations at the MP2/6-311G** level are -137.2, -110.5, -101.1, -89.6, and -84.1 kcal/mol, respectively. The viscosity and ionic conductivity of the alkali TFSA molten salts have strong correlation with the magnitude of the attraction. The viscosity increases and the ionic conductivity decreases with the increase of the attraction. The melting points of the alkali TFSA and alkali BETA molten salts also have correlation with the magnitude of the Eform, which strongly suggests that the magnitude of the attraction play important roles in determining the melting points of these molten salts. The anion dependence of the Eform calculated for the complexes is small (less than 2.9 kcal/mol). This shows that the magnitude of the attraction is not the cause of the low melting points of alkali FTA molten salts compared with those of corresponding alkali TFSA molten salts. The electrostatic interactions are the major source of the attraction in the complexes. The electrostatic energies for the most stable TFSA

  20. Multiweek cell culture project for use in upper-level biology laboratories.

    Science.gov (United States)

    Marion, Rebecca E; Gardner, Grant E; Parks, Lisa D

    2012-06-01

    This article describes a laboratory protocol for a multiweek project piloted in a new upper-level biology laboratory (BIO 426) using cell culture techniques. Human embryonic kidney-293 cells were used, and several culture media and supplements were identified for students to design their own experiments. Treatments included amino acids, EGF, caffeine, epinephrine, heavy metals, and FBS. Students researched primary literature to determine their experimental variables, made their own solutions, and treated their cells over a period of 2 wk. Before this, a sterile technique laboratory was developed to teach students how to work with the cells and minimize contamination. Students designed their experiments, mixed their solutions, seeded their cells, and treated them with their control and experimental media. Students had the choice of manipulating a number of variables, including incubation times, exposure to treatment media, and temperature. At the end of the experiment, students observed the effects of their treatment, harvested and dyed their cells, counted relative cell numbers in control and treatment flasks, and determined the ratio of living to dead cells using a hemocytometer. At the conclusion of the experiment, students presented their findings in a poster presentation. This laboratory can be expanded or adapted to include additional cell lines and treatments. The ability to design and implement their own experiments has been shown to increase student engagement in the biology-related laboratory activities as well as develop the critical thinking skills needed for independent research.

  1. Hydrogen Research for Spaceport and Space-Based Applications: Fuel Cell Projects

    Science.gov (United States)

    Anderson, Tim; Balaban, Canan

    2008-01-01

    The activities presented are a broad based approach to advancing key hydrogen related technologies in areas such as fuel cells, hydrogen production, and distributed sensors for hydrogen-leak detection, laser instrumentation for hydrogen-leak detection, and cryogenic transport and storage. Presented are the results from research projects, education and outreach activities, system and trade studies. The work will aid in advancing the state-of-the-art for several critical technologies related to the implementation of a hydrogen infrastructure. Activities conducted are relevant to a number of propulsion and power systems for terrestrial, aeronautics and aerospace applications. Fuel cell research focused on proton exchange membranes (PEM), solid oxide fuel cells (SOFC). Specific technologies included aircraft fuel cell reformers, new and improved electrodes, electrolytes, interconnect, and seals, modeling of fuel cells including CFD coupled with impedance spectroscopy. Research was conducted on new materials and designs for fuel cells, along with using embedded sensors with power management electronics to improve the power density delivered by fuel cells. Fuel cell applications considered were in-space operations, aviation, and ground-based fuel cells such as; powering auxiliary power units (APUs) in aircraft; high power density, long duration power supplies for interplanetary missions (space science probes and planetary rovers); regenerative capabilities for high altitude aircraft; and power supplies for reusable launch vehicles.

  2. Neutron thermalization in reactor lattice cells: An NPY-project report

    International Nuclear Information System (INIS)

    Stamm'ler, R.J.J.; Takac, S.M.; Weiss, Z.J.

    1966-01-01

    The NPY-Project is a joint research programme in reactor physics between Norway, Poland, Yugoslavia and the International Atomic Energy Agency. One of the tasks of the project was to make a theoretical and experimental investigation of the phenomena of neutron thermalization in lattice cells, and this work is covered by the present monograph. The different lattices of the zero-power assemblies in the NPY countries offered ample opportunity for the theoreticians and experimentalists to test and compare their methods, and the exchange of experiences was stimulating and valuable. 85 refs, 26 figs, 19 tabs

  3. Fuel Cell-Powered Lift Truck Fleet Deployment Projects Final Technical Report May 2014

    Energy Technology Data Exchange (ETDEWEB)

    Klingler, James J [GENCO Infrastructure Solutions, Inc.

    2014-05-06

    The overall objectives of this project were to evaluate the performance, operability and safety of fork lift trucks powered by fuel cells in large distribution centers. This was accomplished by replacing the batteries in over 350 lift trucks with fuel cells at five distribution centers operated by GENCO. The annual cost savings of lift trucks powered by fuel cell power units was between $2,400 and $5,300 per truck compared to battery powered lift trucks, excluding DOE contributions. The greatest savings were in fueling labor costs where a fuel cell powered lift truck could be fueled in a few minutes per day compared to over an hour for battery powered lift trucks which required removal and replacement of batteries. Lift truck operators where generally very satisfied with the performance of the fuel cell power units, primarily because there was no reduction in power over the duration of a shift as experienced with battery powered lift trucks. The operators also appreciated the fast and easy fueling compared to the effort and potential risk of injury associated with switching heavy batteries in and out of lift trucks. There were no safety issues with the fueling or operation of the fuel cells. Although maintenance costs for the fuel cells were higher than for batteries, these costs are expected to decrease significantly in the next generation of fuel cells, making them even more cost effective.

  4. Spectral network based on component cells under the SOPHIA European project

    Energy Technology Data Exchange (ETDEWEB)

    Núñez, Rubén, E-mail: ruben.nunez@ies-def.upm.es; Antón, Ignacio; Askins, Steve; Sala, Gabriel [Instituto de Energía Solar - Universidad Politécnica de Madrid, Ciudad Universitaria, 28040 Madrid (Spain); Domínguez, César; Voarino, Philippe [CEA-INES, 50 avenue du Lac Léman, 73375 Le Bourget-du-Lac (France); Steiner, Marc; Siefer, Gerald [Fraunhofer ISE, Heidenhofstr. 2, 79110 Freiburg (Germany); Fucci, Rafaelle; Roca, Franco [ENEA, P.le E.Fermi 1, Località Granatello, 80055 Portici (Italy); Minuto, Alessandro; Morabito, Paolo [RSE, Via Rubattino 54, 20134 Milan (Italy)

    2015-09-28

    In the frame of the European project SOPHIA, a spectral network based on component (also called isotypes) cells has been created. Among the members of this project, several spectral sensors based on component cells and collimating tubes, so-called spectroheliometers, were installed in the last years, allowing the collection of minute-resolution spectral data useful for CPV systems characterization across Europe. The use of spectroheliometers has been proved useful to establish the necessary spectral conditions to perform power rating of CPV modules and systems. If enough data in a given period of time is collected, ideally a year, it is possible to characterize spectrally the place where measurements are taken, in the same way that hours of annual irradiation can be estimated using a pyrheliometer.

  5. Fuel cells in railway systems. Project report; Brennstoffzellen im Schienenverkehr. Projektbericht

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-06-01

    The project report describes the state of the art of fuel cell technology and the specific requirements of railway systems. Potential applications in the state of Schleswig-Holstein are gone into. [German] In diesem Projektbericht wird der Stand der Brennstoffzellentechnik und die Entwicklung von Anforderungen des Schienenverkehrs an diese Technik ermittelt. Darueber hinaus wird untersucht, inwieweit eine Modellregion Schleswig-Holstein zur weiteren Entwicklung der Technik beitragen kann.

  6. Advanced Manufacturing Technologies (AMT): Additive Manufactured Hot Fire Planning and Testing in GRC Cell 32 Project

    Science.gov (United States)

    Fikes, John C.

    2014-01-01

    The objective of this project is to hot fire test an additively manufactured thrust chamber assembly TCA (injector and thrust chamber). GRC will install the additively manufactured Inconel 625 injector, two additively manufactured (SLM) water cooled Cu-Cr thrust chamber barrels and one additively manufactured (SLM) water cooled Cu-Cr thrust chamber nozzle on the test stand in Cell 32 and perform hot fire testing of the integrated TCA.

  7. Characterization of the Process Mechanical Cell at the West Valley Demonstration Project

    International Nuclear Information System (INIS)

    Drake, John; Schneider, Ken; Choroser, Jeff; Hughes, Karl

    2003-01-01

    The West Valley Demonstration Project has initiated decontamination and dismantlement (D and D) of the most highly radioactive and contaminated cells in a former spent nuclear fuel reprocessing plant. The goals of the D and D project are to remove loose debris in the cells and estimate the residual radioactivity level of legacy plant equipment. To support accomplishment of these goals, a unique characterization approach was developed to gather the information to meet anticipated Waste Isolation Pilot Plant (WIPP) acceptance criteria for remote-handled transuranic waste, and to facilitate segregation and packaging operations. Implementation of the characterization approach included the development and use of innovative, remote technology for measuring gamma radiation within the hot cell. The technology was used to identify and quantify radiation from individual debris items in radiation fields up to 2,000 R/hr (20 sieverts/hr). Sampling and analysis of the debris were also performed via remote handling means. Significant challenges associated with characterizing the highly radioactive and highly contaminated hot cells were encountered. The innovative solutions for meeting these challenges are applicable throughout the Department of Energy Complex and help support the goal of targeting D and D efforts toward reducing risks to public health and the environment

  8. Projection specificity in heterogeneous locus coeruleus cell populations: implications for learning and memory

    Science.gov (United States)

    Uematsu, Akira; Tan, Bao Zhen

    2015-01-01

    Noradrenergic neurons in the locus coeruleus (LC) play a critical role in many functions including learning and memory. This relatively small population of cells sends widespread projections throughout the brain including to a number of regions such as the amygdala which is involved in emotional associative learning and the medial prefrontal cortex which is important for facilitating flexibility when learning rules change. LC noradrenergic cells participate in both of these functions, but it is not clear how this small population of neurons modulates these partially distinct processes. Here we review anatomical, behavioral, and electrophysiological studies to assess how LC noradrenergic neurons regulate these different aspects of learning and memory. Previous work has demonstrated that subpopulations of LC noradrenergic cells innervate specific brain regions suggesting heterogeneity of function in LC neurons. Furthermore, noradrenaline in mPFC and amygdala has distinct effects on emotional learning and cognitive flexibility. Finally, neural recording data show that LC neurons respond during associative learning and when previously learned task contingencies change. Together, these studies suggest a working model in which distinct and potentially opposing subsets of LC neurons modulate particular learning functions through restricted efferent connectivity with amygdala or mPFC. This type of model may provide a general framework for understanding other neuromodulatory systems, which also exhibit cell type heterogeneity and projection specificity. PMID:26330494

  9. From Never Born Proteins to Minimal Living Cells: two projects in synthetic biology.

    Science.gov (United States)

    Luisi, Pier Luigi; Chiarabelli, Cristiano; Stano, Pasquale

    2006-12-01

    The Never Born Proteins (NBPs) and the Minimal Cell projects are two currently developed research lines belonging to the field of synthetic biology. The first deals with the investigation of structural and functional properties of de novo proteins with random sequences, selected and isolated using phage display methods. The minimal cell is the simplest cellular construct which displays living properties, such as self-maintenance, self-reproduction and evolvability. The semi-synthetic approach to minimal cells involves the use of extant genes and proteins in order to build a supramolecular construct based on lipid vesicles. Results and outlooks on these two research lines are shortly discussed, mainly focusing on their relevance to the origin of life studies.

  10. CAUDAL MEDULLARY PATHWAYS TO LUMBOSACRAL MOTONEURONAL CELL GROUPS IN THE CAT - EVIDENCE FOR DIRECT PROJECTIONS POSSIBLY REPRESENTING THE FINAL COMMON PATHWAY FOR LORDOSIS

    NARCIS (Netherlands)

    VANDERHORST, VGJM; HOLSTEGE, G

    1995-01-01

    The nucleus retroambiguus (NRA) projects to distinct brainstem and cervical and thoracic cord motoneuronal cell groups. The present paper describes NRA projections to distinct motoneuronal cell groups in the lumbar enlargement. Lumbosacral injections of wheat germ agglutinin-horseradish peroxidase

  11. Caudal Medullary Pathways To Lumbosacral Motoneuronal Cell Groups In The Cat; Evidence For Direct Projections Possibly Representing The Final Common Pathway For Lordosis.

    NARCIS (Netherlands)

    VanderHorst, Veronique G.J.M.; Holstege, Gert

    1995-01-01

    The nucleus retroambiguus (NRA) projects to distinct brainstem and cervical and thoracic cord motoneuronal cell groups. The present paper describes NRA projections to distinct motoneuronal cell groups in the lumbar enlargement. Lumbosacral injections of wheat germ agglutinin-horseradish peroxidase

  12. Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections.

    Science.gov (United States)

    Kay, Jeremy N; De la Huerta, Irina; Kim, In-Jung; Zhang, Yifeng; Yamagata, Masahito; Chu, Monica W; Meister, Markus; Sanes, Joshua R

    2011-05-25

    The retina contains ganglion cells (RGCs) that respond selectively to objects moving in particular directions. Individual members of a group of ON-OFF direction-selective RGCs (ooDSGCs) detect stimuli moving in one of four directions: ventral, dorsal, nasal, or temporal. Despite this physiological diversity, little is known about subtype-specific differences in structure, molecular identity, and projections. To seek such differences, we characterized mouse transgenic lines that selectively mark ooDSGCs preferring ventral or nasal motion as well as a line that marks both ventral- and dorsal-preferring subsets. We then used the lines to identify cell surface molecules, including Cadherin 6, CollagenXXVα1, and Matrix metalloprotease 17, that are selectively expressed by distinct subsets of ooDSGCs. We also identify a neuropeptide, CART (cocaine- and amphetamine-regulated transcript), that distinguishes all ooDSGCs from other RGCs. Together, this panel of endogenous and transgenic markers distinguishes the four ooDSGC subsets. Patterns of molecular diversification occur before eye opening and are therefore experience independent. They may help to explain how the four subsets obtain distinct inputs. We also demonstrate differences among subsets in their dendritic patterns within the retina and their axonal projections to the brain. Differences in projections indicate that information about motion in different directions is sent to different destinations.

  13. I Want More and Better Cells! - An Outreach Project about Stem Cells and Its Impact on the General Population.

    Science.gov (United States)

    Varela Amaral, Sara; Forte, Teresa; Ramalho-Santos, João; Girão da Cruz, M Teresa

    2015-01-01

    Although science and technology impact every aspect of modern societies, there is still an extensive gap between science and society, which impairs the full exercise of citizenship. In the particular case of biomedical research increased investment should be accompanied by parallel efforts in terms of public information and engagement. We have carried out a project involving the production and evaluation of educational contents focused on stem cells - illustrated newspaper chronicles, radio interviews, a comic book, and animated videos - and monitored their impact on the Portuguese population. The study of the outreach materials in a heterogeneous sample of the population suggests that they are valuable tools to disseminate scientific messages, and that this is especially true for the comic-book format. Furthermore, the data showed that clear and stimulating outreach materials, that are able to teach new concepts and to promote critical thinking, increase engagement in science at different levels, depending on the depth of the concepts involved. Additionally, these materials can influence political, social and personal attitudes toward science. These results, together with the importance attributed to scientific research in stem cells by the population sampled, validates the diffusion of such materials as a significant contribution towards an overall public understanding and engagement in contemporary science, and this strategy should thus be considered in future projects. Regardless, stringent quality control must be implemented in order to efficiently communicate accurate scientific developments, and the public stimulated in terms of finding additional sources of reliable information.

  14. I Want More and Better Cells! – An Outreach Project about Stem Cells and Its Impact on the General Population

    Science.gov (United States)

    Varela Amaral, Sara; Forte, Teresa; Ramalho-Santos, João; Girão da Cruz, M. Teresa

    2015-01-01

    Although science and technology impact every aspect of modern societies, there is still an extensive gap between science and society, which impairs the full exercise of citizenship. In the particular case of biomedical research increased investment should be accompanied by parallel efforts in terms of public information and engagement. We have carried out a project involving the production and evaluation of educational contents focused on stem cells - illustrated newspaper chronicles, radio interviews, a comic book, and animated videos - and monitored their impact on the Portuguese population. The study of the outreach materials in a heterogeneous sample of the population suggests that they are valuable tools to disseminate scientific messages, and that this is especially true for the comic-book format. Furthermore, the data showed that clear and stimulating outreach materials, that are able to teach new concepts and to promote critical thinking, increase engagement in science at different levels, depending on the depth of the concepts involved. Additionally, these materials can influence political, social and personal attitudes toward science. These results, together with the importance attributed to scientific research in stem cells by the population sampled, validates the diffusion of such materials as a significant contribution towards an overall public understanding and engagement in contemporary science, and this strategy should thus be considered in future projects. Regardless, stringent quality control must be implemented in order to efficiently communicate accurate scientific developments, and the public stimulated in terms of finding additional sources of reliable information. PMID:26222053

  15. Development of analytical cell support for vitrification at the West Valley Demonstration Project. Topical report

    Energy Technology Data Exchange (ETDEWEB)

    Barber, F.H.; Borek, T.T.; Christopher, J.Z. [and others

    1997-12-01

    Analytical and Process Chemistry (A&PC) support is essential to the high-level waste vitrification campaign at the West Valley Demonstration Project (WVDP). A&PC characterizes the waste, providing information necessary to formulate the recipe for the target radioactive glass product. High-level waste (HLW) samples are prepared and analyzed in the analytical cells (ACs) and Sample Storage Cell (SSC) on the third floor of the main plant. The high levels of radioactivity in the samples require handling them in the shielded cells with remote manipulators. The analytical hot cells and third floor laboratories were refurbished to ensure optimal uninterrupted operation during the vitrification campaign. New and modified instrumentation, tools, sample preparation and analysis techniques, and equipment and training were required for A&PC to support vitrification. Analytical Cell Mockup Units (ACMUs) were designed to facilitate method development, scientist and technician training, and planning for analytical process flow. The ACMUs were fabricated and installed to simulate the analytical cell environment and dimensions. New techniques, equipment, and tools could be evaluated m in the ACMUs without the consequences of generating or handling radioactive waste. Tools were fabricated, handling and disposal of wastes was addressed, and spatial arrangements for equipment were refined. As a result of the work at the ACMUs the remote preparation and analysis methods and the equipment and tools were ready for installation into the ACs and SSC m in July 1995. Before use m in the hot cells, all remote methods had been validated and four to eight technicians were trained on each. Fine tuning of the procedures has been ongoing at the ACs based on input from A&PC technicians. Working at the ACs presents greater challenges than had development at the ACMUs. The ACMU work and further refinements m in the ACs have resulted m in a reduction m in analysis turnaround time (TAT).

  16. Development of analytical cell support for vitrification at the West Valley Demonstration Project. Topical report

    International Nuclear Information System (INIS)

    Barber, F.H.; Borek, T.T.; Christopher, J.Z.

    1997-12-01

    Analytical and Process Chemistry (A ampersand PC) support is essential to the high-level waste vitrification campaign at the West Valley Demonstration Project (WVDP). A ampersand PC characterizes the waste, providing information necessary to formulate the recipe for the target radioactive glass product. High-level waste (HLW) samples are prepared and analyzed in the analytical cells (ACs) and Sample Storage Cell (SSC) on the third floor of the main plant. The high levels of radioactivity in the samples require handling them in the shielded cells with remote manipulators. The analytical hot cells and third floor laboratories were refurbished to ensure optimal uninterrupted operation during the vitrification campaign. New and modified instrumentation, tools, sample preparation and analysis techniques, and equipment and training were required for A ampersand PC to support vitrification. Analytical Cell Mockup Units (ACMUs) were designed to facilitate method development, scientist and technician training, and planning for analytical process flow. The ACMUs were fabricated and installed to simulate the analytical cell environment and dimensions. New techniques, equipment, and tools could be evaluated m in the ACMUs without the consequences of generating or handling radioactive waste. Tools were fabricated, handling and disposal of wastes was addressed, and spatial arrangements for equipment were refined. As a result of the work at the ACMUs the remote preparation and analysis methods and the equipment and tools were ready for installation into the ACs and SSC m in July 1995. Before use m in the hot cells, all remote methods had been validated and four to eight technicians were trained on each. Fine tuning of the procedures has been ongoing at the ACs based on input from A ampersand PC technicians. Working at the ACs presents greater challenges than had development at the ACMUs. The ACMU work and further refinements m in the ACs have resulted m in a reduction m in

  17. Cardiac cell modelling: Observations from the heart of the cardiac physiome project

    KAUST Repository

    Fink, Martin; Niederer, Steven A.; Cherry, Elizabeth M.; Fenton, Flavio H.; Koivumä ki, Jussi T.; Seemann, Gunnar; Thul, Rü diger; Zhang, Henggui; Sachse, Frank B.; Beard, Dan; Crampin, Edmund J.; Smith, Nicolas P.

    2011-01-01

    In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In particular we focus on the relationship between experimental data and model parameterisation across a range of model types and cellular physiological systems. Finally, in the context of parameter identification and model reuse within the Cardiac Physiome, we suggest some future priority areas for this field. © 2010 Elsevier Ltd.

  18. Quality assurance program plan for 324 Building B-Cell safety cleanout project (BCCP)

    International Nuclear Information System (INIS)

    Tanke, J.M.

    1997-01-01

    This Quality Assurance Program Plan (QAPP) provides information on how the Quality Assurance Program is implemented for the 324 Building B-Cell Safety Cleanout Project (BCCP). This QAPP is responsive to the Westinghouse Hanford Company Quality Assurance Program and Implementation Plan, WHC-SP-1131, for 10 CFR 830.120, Nuclear Safety Management, Quality Assurance Requirements; and DOE Order 5700.6C, Quality Assurance. This QAPP supersedes PNNL PNL-MA-70 QAP Quality Assurance Plan No. WTC-050 Rev. 2, issue date May 3, 1996. This QAPP has been developed specifically for the BCCP. It applies to those items and tasks which affect the completion of activities identified in the work breakdown structure of the Project Management Plan (PMP). These activities include all aspects of decontaminating B-Cell and project related operations within the 324 Building as it relates to the specific activities of this project. General facility activities (i.e. 324 Building Operations) are covered in the Building 324 QAPP. In addition, this QAPP supports the related quality assurance activities addressed in CM-2-14, Hazardous Material Packaging and Shipping, and HSRCM-1, Hanford Site Radiological Control Manual, The 324 Building is currently transitioning from being a Pacific Northwest National Laboratory (PNNL) managed facility to a B and W Hanford Company (BWHC) managed facility. During this transition process existing, PNNL procedures and documents will be utilized until replaced by BWHC procedures and documents. These documents conform to the requirements found in PNL-MA-70, Quality Assurance Manual and PNL-MA-8 1, Hazardous Materials Shipping Manual. The Quality Assurance Program Index (QAPI) contained in Table 1 provides a matrix which shows how project activities relate to 10 CFR 83 0.120 and 5700.6C criteria. Quality Assurance program requirements will be addressed separate from the requirements specified in this document. Other Hanford Site organizations/companies may be

  19. Teaching Cell Biology to Dental Students with a Project-Based Learning Approach.

    Science.gov (United States)

    Costa-Silva, Daniela; Côrtes, Juliana A; Bachinski, Rober F; Spiegel, Carolina N; Alves, Gutemberg G

    2018-03-01

    Although the discipline of cell biology (CB) is part of the curricula of predoctoral dental schools, students often fail to recognize its practical relevance. The aim of this study was to assess the effectiveness of a practical-theoretical project-based course in closing the gaps among CB, scientific research, and dentistry for dental students. A project-based learning course was developed with nine sequential lessons to evaluate 108 undergraduate dental students enrolled in CB classes of a Brazilian school of dentistry during 2013-16. To highlight the relevance of in vitro studies in the preclinical evaluation of dental materials at the cellular level, the students were challenged to complete the process of drafting a protocol and performing a cytocompatibility assay for a bone substitute used in dentistry. Class activities included small group discussions, scientific database search and article presentations, protocol development, lab experimentation, and writing of a final scientific report. A control group of 31 students attended only one laboratory class on the same theme, and the final reports were compared between the two groups. The results showed that the project-based learning students had superior outcomes in acknowledging the relevance of in vitro methods during biocompatibility testing. Moreover, they produced scientifically sound reports with more content on methodological issues, the relationship with dentistry, and the scientific literature than the control group (p<0.05). The project-based learning students also recognized a higher relevance of scientific research and CB to dental practice. These results suggest that a project-based approach can help contextualize scientific research in dental curricula.

  20. High Density Radiation Shielding Concretes for Hot Cells of 99mTc Project

    International Nuclear Information System (INIS)

    Sakr, K.

    2006-01-01

    High density concrete [more than 3.6 ton/m 3 (3.6x10 3 kg/m 3 )] was prepared to be used as a radiation shielding concrete (RSC) for hot-cells in gel technetium project at inshas to attenuate gamma radiation emitted from radioactive sources. different types of concrete were prepared by mixing local mineral aggregates mainly gravel and ilmenite . iron shots were added to the concrete mixture proportion as partial replacement of heavy aggregates to increase its density. the physical properties of prepared concrete in both plastic and hardened phases were investigated. compressive strength and radiation attenuation of gamma rays were determined. Results showed that ilmenite concrete mixed with iron shots had the highest density suitable to be use as RSC according to the chinese hot cell design requirements. Recommendations to avoid some technical problems of manufacturing radiation shielding concrete were maintained

  1. Learning how scientists work: experiential research projects to promote cell biology learning and scientific process skills.

    Science.gov (United States)

    DebBurman, Shubhik K

    2002-01-01

    Facilitating not only the mastery of sophisticated subject matter, but also the development of process skills is an ongoing challenge in teaching any introductory undergraduate course. To accomplish this goal in a sophomore-level introductory cell biology course, I require students to work in groups and complete several mock experiential research projects that imitate the professional activities of the scientific community. I designed these projects as a way to promote process skill development within content-rich pedagogy and to connect text-based and laboratory-based learning with the world of contemporary research. First, students become familiar with one primary article from a leading peer-reviewed journal, which they discuss by means of PowerPoint-based journal clubs and journalism reports highlighting public relevance. Second, relying mostly on primary articles, they investigate the molecular basis of a disease, compose reviews for an in-house journal, and present seminars in a public symposium. Last, students author primary articles detailing investigative experiments conducted in the lab. This curriculum has been successful in both quarter-based and semester-based institutions. Student attitudes toward their learning were assessed quantitatively with course surveys. Students consistently reported that these projects significantly lowered barriers to primary literature, improved research-associated skills, strengthened traditional pedagogy, and helped accomplish course objectives. Such approaches are widely suited for instructors seeking to integrate process with content in their courses.

  2. The SCD - Stem Cell Differentiation ESA Project: Preparatory Work for the Spaceflight Mission

    Science.gov (United States)

    Versari, Silvia; Barenghi, Livia; van Loon, Jack; Bradamante, Silvia

    2016-04-01

    Due to spaceflight, astronauts experience serious, weightlessness-induced bone loss because of an unbalanced process of bone remodeling that involves bone marrow mesenchymal stem cells (BMSCs), as well as osteoblasts, osteocytes, and osteoclasts. The effects of microgravity on osteo-cells have been extensively studied, but it is only recently that consideration has been given to the role of BMSCs. Previous researches indicated that human BMSCs cultured in simulated microgravity (sim-μg) alter their proliferation and differentiation. The spaceflight opportunities for biomedical experiments are rare and suffer from a number of operative constraints that could bias the validity of the experiment itself, but remain a unique opportunity to confirm and explain the effects due to microgravity, that are only partially activated/detectable in simulated conditions. For this reason, we carefully prepared the SCD - STEM CELLS DIFFERENTIATION experiment, selected by the European Space Agency (ESA) and now on the International Space Station (ISS). Here we present the preparatory studies performed on ground to adapt the project to the spaceflight constraints in terms of culture conditions, fixation and storage of human BMSCs in space aiming at satisfying the biological requirements mandatory to retrieve suitable samples for post-flight analyses. We expect to understand better the molecular mechanisms governing human BMSC growth and differentiation hoping to outline new countermeasures against astronaut bone loss.

  3. Finite state projection based bounds to compare chemical master equation models using single-cell data

    Energy Technology Data Exchange (ETDEWEB)

    Fox, Zachary [School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado 80523 (United States); Neuert, Gregor [Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 (United States); Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232 (United States); Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, Tennessee 37232 (United States); Munsky, Brian [School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado 80523 (United States); Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado 80523 (United States)

    2016-08-21

    Emerging techniques now allow for precise quantification of distributions of biological molecules in single cells. These rapidly advancing experimental methods have created a need for more rigorous and efficient modeling tools. Here, we derive new bounds on the likelihood that observations of single-cell, single-molecule responses come from a discrete stochastic model, posed in the form of the chemical master equation. These strict upper and lower bounds are based on a finite state projection approach, and they converge monotonically to the exact likelihood value. These bounds allow one to discriminate rigorously between models and with a minimum level of computational effort. In practice, these bounds can be incorporated into stochastic model identification and parameter inference routines, which improve the accuracy and efficiency of endeavors to analyze and predict single-cell behavior. We demonstrate the applicability of our approach using simulated data for three example models as well as for experimental measurements of a time-varying stochastic transcriptional response in yeast.

  4. FSA 2008 Digital Orthophoto Metadata

    Data.gov (United States)

    Minnesota Department of Natural Resources — This data set contains lines and/or polygons delineating the boundary between DOQQ imagery used in the creation of a compressed county mosaic (CCM). The DOQQ and CCM...

  5. Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics.

    Science.gov (United States)

    Paulson, Kelly G; Park, Song Youn; Vandeven, Natalie A; Lachance, Kristina; Thomas, Hannah; Chapuis, Aude G; Harms, Kelly L; Thompson, John A; Bhatia, Shailender; Stang, Andreas; Nghiem, Paul

    2018-03-01

    Merkel cell carcinoma (MCC) incidence rates are rising and strongly age-associated, relevant for an aging population. Determine MCC incidence in the United States and project incident cases through the year 2025. Registry data were obtained from the SEER-18 Database, containing 6600 MCC cases. Age- and sex-adjusted projections were generated using US census data. During 2000-2013, the number of reported solid cancer cases increased 15%, melanoma cases increased 57%, and MCC cases increased 95%. In 2013, the MCC incidence rate was 0.7 cases/100,000 person-years in the United States, corresponding to 2488 cases/year. MCC incidence increased exponentially with age, from 0.1 to 1.0 to 9.8 (per 100,000 person-years) among age groups 40-44 years, 60-64 years, and ≥85 years, respectively. Due to aging of the Baby Boomer generation, US MCC incident cases are predicted to climb to 2835 cases/year in 2020 and 3284 cases/year in 2025. We assumed that the age-adjusted incidence rate would stabilize, and thus, the number of incident cases we projected might be an underestimate. An aging population is driving brisk increases in the number of new MCC cases in the United States. This growing impact combined with the rapidly evolving therapeutic landscape warrants expanded awareness of MCC diagnosis and management. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  6. The seed of change in society. Diffusion of solar cell systems in housing by means of pilot projects

    International Nuclear Information System (INIS)

    Van Mierlo, B.C.

    2002-01-01

    The central question in this thesis is: in what way can pilot projects contribute to the diffusion of new sustainable technologies, in particular solar cell systems in housing units. The reason for this is, in the first place, that trials, demonstration projects, practical experiments and market introduction projects are often launched by firms and subsidised by the state. The objective of such projects, referred to here as pilot projects, is in general to prepare the market introduction of new technologies. However, these projects are often realised and financed without much information being available on how they operate: about how they could prepare the market launch and how this function could be optimised. The second reason is that since the end of the 1980s the expectations in the Netherlands in respect of solar cell systems (PV systems) connected to the electricity grid have been high. These systems could have great advantages for the environment and after 2010 could be the most important source of sustainable energy. The government sees housing as the most promising market segment for these systems. It is recognised that certain major bottlenecks have to be solved before a large-scale diffusion is possible. According to the niche approach, the basic starting point of this thesis, this means that the existing social-technological regime needs to change: the rules and infrastructure according to which the existing technologies are, as it were, considered self-evident, and which hinder the introduction of new technologies. Subsidised pilot projects form a protected market niche that can stimulate a change in the regime by learning and by the social embedding of the learning experiences. According to this approach, a protected market niche is a necessary component of state-supported innovation policy if market niches do not arise spontaneously. It is, however, a limited instrument since the ultimate impact on existing regimes depends mainly on external factors

  7. Identification of retinal ganglion cells and their projections involved in central transmission of information about upward and downward image motion.

    Directory of Open Access Journals (Sweden)

    Keisuke Yonehara

    Full Text Available The direction of image motion is coded by direction-selective (DS ganglion cells in the retina. Particularly, the ON DS ganglion cells project their axons specifically to terminal nuclei of the accessory optic system (AOS responsible for optokinetic reflex (OKR. We recently generated a knock-in mouse in which SPIG1 (SPARC-related protein containing immunoglobulin domains 1-expressing cells are visualized with GFP, and found that retinal ganglion cells projecting to the medial terminal nucleus (MTN, the principal nucleus of the AOS, are comprised of SPIG1+ and SPIG1(- ganglion cells distributed in distinct mosaic patterns in the retina. Here we examined light responses of these two subtypes of MTN-projecting cells by targeted electrophysiological recordings. SPIG1+ and SPIG1(- ganglion cells respond preferentially to upward motion and downward motion, respectively, in the visual field. The direction selectivity of SPIG1+ ganglion cells develops normally in dark-reared mice. The MTN neurons are activated by optokinetic stimuli only of the vertical motion as shown by Fos expression analysis. Combination of genetic labeling and conventional retrograde labeling revealed that axons of SPIG1+ and SPIG1(- ganglion cells project to the MTN via different pathways. The axon terminals of the two subtypes are organized into discrete clusters in the MTN. These results suggest that information about upward and downward image motion transmitted by distinct ON DS cells is separately processed in the MTN, if not independently. Our findings provide insights into the neural mechanisms of OKR, how information about the direction of image motion is deciphered by the AOS.

  8. DOD Residential Proton Exchange Membrane (PEM) Fuel Cell Demonstration Program. Volume 2. Summary of Fiscal Year 2001-2003 Projects

    Science.gov (United States)

    2005-09-01

    produced many of the Beatles 1970s recordings. This facility was selected to host the UK PEM demonstration project from a selection of four potential sites...funded the Department of Defense (DOD) Residential PEM Demonstration Project to demonstrate domestically-produced, residential Proton Exchange Membrane...PEM) fuel cells at DOD Facilities. The objectives were to: (1) assess PEM fuel cells’ role in supporting sustainability at military installations

  9. Requirements for future control room and visualisation features in the Web-of-Cells framework defined in the ELECTRA project

    DEFF Research Database (Denmark)

    Tornelli, Carlo; Zuelli, Roberto; Marinell, Mattia

    2017-01-01

    project, that proposes a new Web-of-Cell (WoC) power system control architecture. Dedicated visualisation features are proposed, aimed to support the control room operators activities in a WoC-oriented approach. Furthermore, the work takes into account the point of view of network operators about future...

  10. Susceptibility of cancer cells to β-lapachone is enhanced by ionizing radiation

    International Nuclear Information System (INIS)

    Park, Heon Joo; Ahn, Ki-Jung; Ahn, Seung-Do; Choi, Eunkyung; Lee, Sang Wook; Williams, Brent; Kim, Eun Jung; Griffin, Robert; Bey, Erik A.; Bornmann, William G.; Gao, Jinming; Park, Heon Jin; Boothman, David A.; Song, Chang W.

    2005-01-01

    Purpose: To reveal the interaction between β-lapachone (β-lap) and ionizing radiation (IR) in causing clonogenic death in cancer cells and to elucidate the potential usefulness of β-lap treatment in combination with radiotherapy of cancer. Methods and materials: FSaII tumor cells of C3H mice were used. The cytotoxicity of β-lap alone or in combination with IR in vitro was determined using clonogenic survival assay method. The IR-induced changes in the expression and the enzymatic activity of NAD(P)H:quinone oxidoreductase (NQO1), a mediator of β-lap cytotoxicity, were elucidated and the relationship between the NQO1 level and the sensitivity of cells to β-lap was investigated. The combined effect of IR and β-lap to suppress tumor growth was studied using FSaII tumors grown subcutaneously in the thigh of C3H mice. Results: β-Lap caused clonogenic death of FSaII tumor cells in vitro in a dose- and time-dependent manner. When cells were treated first with β-lap and then exposed to IR in vitro, the resultant cell death was only additive. On the contrary, exposing cells to IR at 2.5 Gy first and then treating the cells with β-lap killed the cells in a synergistic manner. Importantly, the 2.5 Gy cells were sensitive to β-lap as long as 10 h after irradiation, which was long after the sublethal radiation damage was repaired. Irradiation of FSaII cells in vitro with 2.5 Gy significantly increased the expression and enzymatic activity of NQO1. The growth delay of FSaII tumors caused by an intraperitoneal injection of β-lap in combination with 20 Gy irradiation of tumor was significantly greater than that caused by β-lap or 20 Gy irradiation alone. Conclusion: The sensitivity of cells to β-lap is dependent on NQO1 activity. IR caused a long-lasting increase in NQO1 activity in cancer cells, thereby sensitizing cells to β-lap and treatment of experimental mouse tumors with IR and β-lap suppressed tumor growth in a synergistic manner. The combination of

  11. Silicon-Light: a European FP7 Project Aiming at High Efficiency Thin Film Silicon Solar Cells on Foil

    DEFF Research Database (Denmark)

    Soppe, W.; Haug, F.-J.; Couty, P.

    2011-01-01

    Silicon-Light is a European FP7 project, which started January 1st, 2010 and aims at development of low cost, high-efficiency thin film silicon solar cells on foil. Three main routes are explored to achieve these goals: a) advanced light trapping by implementing nanotexturization through UV Nano...... calculations of ideal nanotextures for light trapping in thin film silicon solar cells; the fabrication of masters and the replication and roll-to-roll fabrication of these nanotextures. Further, results on ITO variants with improved work function are presented. Finally, the status of cell fabrication on foils...

  12. The MicroActive project: automatic detection of disease-related molecular cell activity

    Science.gov (United States)

    Furuberg, Liv; Mielnik, Michal; Johansen, Ib-Rune; Voitel, Jörg; Gulliksen, Anja; Solli, Lars; Karlsen, Frank; Bayer, Tobias; Schönfeld, Friedhelm; Drese, Klaus; Keegan, Helen; Martin, Cara; O'Leary, John; Riegger, Lutz; Koltay, Peter

    2007-05-01

    The aim of the MicroActive project is to develop an instrument for molecular diagnostics. The instrument will first be tested for patient screening for a group of viruses causing cervical cancer. Two disposable polymer chips with reagents stored on-chip will be inserted into the instrument for each patient sample. The first chip performs sample preparation of the epithelial cervical cells while mRNA amplification and fluorescent detection takes place in the second chip. More than 10 different virus markers will be analysed in one chip. We report results on sub-functions of the amplification chip. The sample is split into smaller droplets, and the droplets move in parallel channels containing different dried reagents for the different analyses. We report experimental results on parallel droplet movement control using one external pump only, combined with hydrophobic valves. Valve burst pressures are controlled by geometry. We show droplet control using valves with burst pressures between 800 and 4500 Pa. We also monitored the re-hydration times for two necessary dried reagents. After sample insertion, uniform concentration of the reagents in the droplet was reached after respectively 60 s and 10 min. These times are acceptable for successful amplification. Finally we have shown positive amplification of HPV type 16 using dried enzymes stored in micro chambers.

  13. Models and simulations for the Danish cell project. Running PowerFactory with OPC and cell controller

    Energy Technology Data Exchange (ETDEWEB)

    Martensen, Nis; Troester, Eckehard [energynautics GmbH, Langen (Germany); Lund, Per [Energinet.dk, Fredericia (Denmark); Holland, Rod [Spirae Inc., Fort Collins, CO (United States)

    2009-07-01

    In emergency situations, the Cell Controller disconnects a distribution grid from the high-voltage network and controls the cell's island operation. The controller thus activates the existing local generation plants to improve the security of supply. The Cell Controller can operate the Cell as a Virtual Power Plant during normal grid-connected operation, thereby implementing an exemplary Smart Grid. Modeling and simulation work is presented. (orig.)

  14. An assessment of plant biointrusion at the Uranium Mill Tailings Remedial Action Project rock-covered disposal cells

    International Nuclear Information System (INIS)

    1990-10-01

    This study is one of a number of special studies that have been conducted regarding various aspects of the Uranium Mill Tailings Remedial Action (UMTRA) Project. This special study was proposed following routine surveillance and maintenance surveys and observations reported in a special study of vegetative covers (DOE, 1988), in which plants were observed growing up through the rock erosion layer at recently completed disposal cells. Some of the plants observed were deep-rooted woody species, and questions concerning root intrusion into disposal cells and the need to control plant growth were raised. The special study discussed in this report was designed to address some of the ramifications of plant growth on disposal cells that have rock covers. The NRC has chosen rock covers over vegetative covers in the arid western United States because licenses cannot substantiate that the vegetative covers ''will be significantly greater than 30 percent and preferably 70 percent,'' which is the amount of ''vegetation required to reduce flow to a point of stability.'' The potential impacts of vegetation growing in rock covers are not addressed by the NRC (1990). The objectives, then, of this study were to determine the species of plants growing on two rock-covered disposal cells, study the rooting pattern of plants on these cells, and identify possible impacts of plant root penetration on these and other UMTRA Project rock-covered cells

  15. Peripheral T cell lymphoma, not otherwise specified (PTCL-NOS). A new prognostic model developed by the International T cell Project Network.

    Science.gov (United States)

    Federico, Massimo; Bellei, Monica; Marcheselli, Luigi; Schwartz, Marc; Manni, Martina; Tarantino, Vittoria; Pileri, Stefano; Ko, Young-Hyeh; Cabrera, Maria E; Horwitz, Steven; Kim, Won S; Shustov, Andrei; Foss, Francine M; Nagler, Arnon; Carson, Kenneth; Pinter-Brown, Lauren C; Montoto, Silvia; Spina, Michele; Feldman, Tatyana A; Lechowicz, Mary J; Smith, Sonali M; Lansigan, Frederick; Gabus, Raul; Vose, Julie M; Advani, Ranjana H

    2018-04-19

    Different models to investigate the prognosis of peripheral T cell lymphoma not otherwise specified (PTCL-NOS) have been developed by means of retrospective analyses. Here we report on a new model designed on data from the prospective T Cell Project. Twelve covariates collected by the T Cell Project were analysed and a new model (T cell score), based on four covariates (serum albumin, performance status, stage and absolute neutrophil count) that maintained their prognostic value in multiple Cox proportional hazards regression analysis was proposed. Among patients registered in the T Cell Project, 311 PTCL-NOS were retained for study. At a median follow-up of 46 months, the median overall survival (OS) and progression-free survival (PFS) was 20 and 10 months, respectively. Three groups were identified at low risk (LR, 48 patients, 15%, score 0), intermediate risk (IR, 189 patients, 61%, score 1-2), and high risk (HiR, 74 patients, 24%, score 3-4), having a 3-year OS of 76% [95% confidence interval 61-88], 43% [35-51], and 11% [4-21], respectively (P < 0·001). Comparing the performance of the T cell score on OS to that of each of the previously developed models, it emerged that the new score had the best discriminant power. The new T cell score, based on clinical variables, identifies a group with very unfavourable outcomes. © 2018 The Authors British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.

  16. Variations in the spectrum of lesions produced in the DNA of cells from mouse tissues after exposure to γ-rays in air-breathing or in artificially anoxic animals

    International Nuclear Information System (INIS)

    Murray, D.; Meyn, R.E.; Vanankeren, S.C.

    1988-01-01

    Few DNA-protein crosslinks (dpc) were detected in the DNA from tumor cells γ-irradiated in vitro; however, in cells from both FSa and NFSa tumors irradiated in situ there was a significant level of protein-concealed ssb, and thus of dpc. These data are most likely the result of the relative hypoxia of a proportion of cells from both the FSa and NFSa tumor in the air-breathing animals. Induction of dpc was further enhanced in the DNA from tumor cells irradiated under anoxic conditions. A significant level of dpc was also observed in jejunal and spleen cells irradiated in vivo; however, since a significant level of protein-concealed breaks was also observed in cells irradiated in vitro, oxygenation appears not to be the only parameter capable of modifying the proportion of protein-concealed ssb, and the effects of proteinase K on the DNA elution rate for normal mouse tissues may be complex. (author)

  17. Translating sickle cell guidelines into practice for primary care providers with Project ECHO

    Directory of Open Access Journals (Sweden)

    Lisa M. Shook

    2016-11-01

    Full Text Available Background: Approximately 100,000 persons with sickle cell disease (SCD live in the United States, including 15,000 in the Midwest. Unfortunately, many patients experience poor health outcomes due to limited access to primary care providers (PCPs who are prepared to deliver evidence-based SCD care. Sickle Treatment and Outcomes Research in the Midwest (STORM is a regional network established to improve care and outcomes for individuals with SCD living in Indiana, Illinois, Michigan, Minnesota, Ohio, and Wisconsin. Methods: STORM investigators hypothesized that Project ECHO® methodology could be replicated to create a low-cost, high-impact intervention to train PCPs in evidence-based care for pediatric and young adult patients with SCD in the Midwest, called STORM TeleECHO. This approach utilizes video technology for monthly telementoring clinics consisting of didactic and case-based presentations focused on the National Heart, Lung and Blood Institute (NHLBI evidence-based guidelines for SCD. Results: Network leads in each of the STORM states assisted with developing the curriculum and are recruiting providers for monthly clinics. To assess STORM TeleECHO feasibility and acceptability, monthly attendance and satisfaction data are collected. Changes in self-reported knowledge, comfort, and practice patterns will be compared with pre-participation, and 6 and 12 months after participation. Conclusions: STORM TeleECHO has the potential to increase implementation of the NHLBI evidence-based guidelines, especially increased use of hydroxyurea, resulting in improvements in the quality of care and outcomes for children and young adults with SCD. This model could be replicated in other pediatric chronic illness conditions to improve PCP knowledge and confidence in delivering evidence-based care.

  18. Central projections of intrinsically photosensitive retinal ganglion cells in the macaque monkey

    DEFF Research Database (Denmark)

    Hannibal, J; Kankipati, L; Strang, C E

    2014-01-01

    ). The ipRGCs regulate other nonimage-forming visual functions such as the pupillary light reflex, masking behavior, and light-induced melatonin suppression. To evaluate whether PACAP-immunoreactive retinal projections are useful as a marker for central projection of ipRGCs in the monkey brain, we......, supporting previous retrograde tracer studies demonstrating that melanopsin-containing retinal projections reach areas in the primate brain involved in both image- and nonimage-forming visual processing....

  19. Fuel Cell Demonstration Project - 200 kW - Phosphoric Acid Fuel Cell Power Plant Located at the National Transportation Research Center: FINAL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Berry, JB

    2005-05-06

    Oak Ridge National Laboratory (ORNL) researches and develops distributed generation technology for the Department of Energy, Energy Efficiency and Renewable Energy Distributed Energy Program. This report describes installation and operation of one such distributed generation system, a United Technology Corporation fuel cell located at the National Transportation Research Center in Knoxville, Tennessee. Data collected from June 2003 to June of 2004, provides valuable insight regarding fuel cell-grid compatibility and the cost-benefit of the fuel cell operation. The NTRC fuel cell included a high-heat recovery option so that use of thermal energy improves project economics and improves system efficiency to 59% year round. During the year the fuel cell supplied a total of 834MWh to the NTRC and provided 300MBtu of hot water. Installation of the NTRC fuel cell was funded by the Distributed Energy Program with partial funding from the Department of Defense's Climate Change Fuel Cell Buy Down Program, administered by the National Energy Technology Laboratory. On-going operational expenses are funded by ORNL's utility budget and are paid from operational cost savings. Technical information and the benefit-cost of the fuel cell are both evaluated in this report and sister reports.

  20. Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CRS-8 ISS space mission - The SPHEROIDS project.

    Science.gov (United States)

    Pietsch, Jessica; Gass, Samuel; Nebuloni, Stefano; Echegoyen, David; Riwaldt, Stefan; Baake, Christin; Bauer, Johann; Corydon, Thomas J; Egli, Marcel; Infanger, Manfred; Grimm, Daniela

    2017-04-01

    Human endothelial cells (ECs) were sent to the International Space Station (ISS) to determine the impact of microgravity on the formation of three-dimensional structures. For this project, an automatic experiment unit (EU) was designed allowing cell culture in space. In order to enable a safe cell culture, cell nourishment and fixation after a pre-programmed timeframe, the materials used for construction of the EUs were tested in regard to their biocompatibility. These tests revealed a high biocompatibility for all parts of the EUs, which were in contact with the cells or the medium used. Most importantly, we found polyether ether ketones for surrounding the incubation chamber, which kept cellular viability above 80% and allowed the cells to adhere as long as they were exposed to normal gravity. After assembling the EU the ECs were cultured therein, where they showed good cell viability at least for 14 days. In addition, the functionality of the automatic medium exchange, and fixation procedures were confirmed. Two days before launch, the ECs were cultured in the EUs, which were afterwards mounted on the SpaceX CRS-8 rocket. 5 and 12 days after launch the cells were fixed. Subsequent analyses revealed a scaffold-free formation of spheroids in space. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells

    Science.gov (United States)

    Song, Chang W.; Lee, Hyemi; Dings, Ruud P. M.; Williams, Brent; Powers, John; Santos, Troy Dos; Choi, Bo-Hwa; Park, Heon Joo

    2012-01-01

    The anti-cancer effects of metformin, the most widely used drug for type 2 diabetes, alone or in combination with ionizing radiation were studied with MCF-7 human breast cancer cells and FSaII mouse fibrosarcoma cells. Clinically achievable concentrations of metformin caused significant clonogenic death in cancer cells. Importantly, metformin was preferentially cytotoxic to cancer stem cells relative to non-cancer stem cells. Metformin increased the radiosensitivity of cancer cells in vitro, and significantly enhanced the radiation-induced growth delay of FSaII tumors (s.c.) in the legs of C3H mice. Both metformin and ionizing radiation activated AMPK leading to inactivation of mTOR and suppression of its downstream effectors such as S6K1 and 4EBP1, a crucial signaling pathway for proliferation and survival of cancer cells, in vitro as well as in the in vivo tumors. Conclusion: Metformin kills and radiosensitizes cancer cells and eradicates radioresistant cancer stem cells by activating AMPK and suppressing mTOR. PMID:22500211

  2. 76 FR 16609 - Proposed Information Collection; Comment Request; Identification of Human Cell Lines Project

    Science.gov (United States)

    2011-03-24

    ... differentiate among cell lines, as described in Designation: ASN-0002 Authentication of Human Cell Lines... NIST (contact information above). III. Data OMB Control Number: None. Form Number: None. Type of Review...

  3. Manufacturing of cells and stacks for SOFC development, test and demonstration projects and SOFC hotbox design development

    Energy Technology Data Exchange (ETDEWEB)

    2008-09-15

    The purpose of this project is to support the continued SOFC development through manufacturing process optimization and manufacturing of SOFC cells and stacks. These cells and stacks will serve as a necessary base for the development activities and for the establishment of a number of test and demonstration activities. The manufacture will also help provide operating experience and reduce manufacturing cost. Another main focus of the manufacturing is to assure technical improvements and reliability. It is imperative to the eventual success of the technology that test and demonstration is carried out in the pre-market conditions that will exist for the next years in the three market segments targeted by TOFC (Distributed generation, micro CHP and APU incl. marine APU). Finally, the project also includes development activities focusing on the stack-system interface (hotbox design development) and on dealing with transients and start up and shut down times, which is of particular importance for APU and micro CHP applications. Three topics are addressed:1) Cell manufacture, including production development, capacity lift and manuf. of cells for test and demonstration; 2) Stack manufacture and test, including a test facility, stack manuf. and test of stacks in a system at HCV; 3) Hotbox design development, including design, prototype construction and testing. The progress of this project is documented. Major achievements are successful manufacture of adequate amounts of cells and stacks according to the application. Furthermore significant over-performance in design, construction and test of a methanol based hotbox prototype as well as publication of this. (au)

  4. Solar cells for Bolivia. Two project supported by the Dutch Ministry of Development Assistance

    International Nuclear Information System (INIS)

    Hassing, P.; Rijssenbeek, W.; De Winter, J.

    1998-01-01

    Since 1992 the Netherlands Development Assistance (NEDA) supports the energy sector in Bolivia, South-America. Next to support on the policy level demonstration projects in the field of renewable energy are financed successfully. Two solar energy projects form the start of a broad introduction of Solar Home Systems in rural areas of Bolivia. The main obstacle is the financing of the plans. 3 refs

  5. Silicon materials task of the Low Cost Solar Array Project: Effect of impurities and processing on silicon solar cells

    Science.gov (United States)

    Hopkins, R. H.; Davis, J. R.; Rohatgi, A.; Hanes, M. H.; Rai-Choudhury, P.; Mollenkopf, H. C.

    1982-01-01

    The effects of impurities and processing on the characteristics of silicon and terrestrial silicon solar cells were defined in order to develop cost benefit relationships for the use of cheaper, less pure solar grades of silicon. The amount of concentrations of commonly encountered impurities that can be tolerated in typical p or n base solar cells was established, then a preliminary analytical model from which the cell performance could be projected depending on the kinds and amounts of contaminants in the silicon base material was developed. The impurity data base was expanded to include construction materials, and the impurity performace model was refined to account for additional effects such as base resistivity, grain boundary interactions, thermal processing, synergic behavior, and nonuniform impurity distributions. A preliminary assessment of long term (aging) behavior of impurities was also undertaken.

  6. The SCD - Stem Cell Differentiation ESA project: preparatory work for the spaceflight mission

    NARCIS (Netherlands)

    Versari, S.; Barenghi, L.; van Loon, J.; Bradamante, S.

    2016-01-01

    Due to spaceflight, astronauts experience serious, weightlessness-induced bone loss because of an unbalanced process of bone remodeling that involves bone marrow mesenchymal stem cells (BMSCs), as well as osteoblasts, osteocytes, and osteoclasts. The effects of microgravity on osteo-cells have been

  7. End of project report on degradation processes in hydrogen fuel cells.

    Science.gov (United States)

    2008-01-01

    Proton exchange membrane (PEM) fuel cells are one of the most popular types of fuel cells. They operate similarly to others with the electrolyte material inbetween the electrodes being a patented polymer called Nafion, made by DuPont. This polyelec...

  8. Cell-Specific Loss of SNAP25 from Cortical Projection Neurons Allows Normal Development but Causes Subsequent Neurodegeneration.

    Science.gov (United States)

    Hoerder-Suabedissen, Anna; Korrell, Kim V; Hayashi, Shuichi; Jeans, Alexander; Ramirez, Denise M O; Grant, Eleanor; Christian, Helen C; Kavalali, Ege T; Wilson, Michael C; Molnár, Zoltán

    2018-05-30

    Synaptosomal associated protein 25 kDa (SNAP25) is an essential component of the SNARE complex regulating synaptic vesicle fusion. SNAP25 deficiency has been implicated in a variety of cognitive disorders. We ablated SNAP25 from selected neuronal populations by generating a transgenic mouse (B6-Snap25tm3mcw (Snap25-flox)) with LoxP sites flanking exon5a/5b. In the presence of Cre-recombinase, Snap25-flox is recombined to a truncated transcript. Evoked synaptic vesicle release is severely reduced in Snap25 conditional knockout (cKO) neurons as shown by live cell imaging of synaptic vesicle fusion and whole cell patch clamp recordings in cultured hippocampal neurons. We studied Snap25 cKO in subsets of cortical projection neurons in vivo (L5-Rbp4-Cre; L6-Ntsr1-Cre; L6b-Drd1a-Cre). cKO neurons develop normal axonal projections, but axons are not maintained appropriately, showing signs of swelling, fragmentation and eventually complete absence. Onset and progression of degeneration are dependent on the neuron type, with L5 cells showing the earliest and most severe axonal loss. Ultrastructural examination revealed that cKO neurites contain autophagosome/lysosome-like structures. Markers of inflammation such as Iba1 and lipofuscin are increased only in adult cKO cortex. Snap25 cKO can provide a model to study genetic interactions with environmental influences in several disorders.

  9. Decontamination and decommissioning of Extraction Cell 3 at the West Valley Demonstration Project. Topical report, January 1982-April 1985

    International Nuclear Information System (INIS)

    Jones, E.D.

    1985-12-01

    This report describes the decontamination and decommissioning (D and D) of Extraction Cell 3 (XC-3) at the West Valley Demonstration Project. XC-3 is one of several cells in the former reprocessing plant required for use in support of the solidification of high-level waste. It became radioactively contaminated during nuclear fuel reprocessing from 1966 to 1972. XC-3 contained systems used in the final uranium extraction cycle. Several pump niche and sample box drains were routed into the cell. The report describes the work performed to accomplish the D and D objectives of removing existing piping and equipment from XC-3 and to reducing radiation and contamination levels, to allow installation of equipment for the Liquid-Waste Treatment System (LWTS). Contaminated debris and equipment inside the cell were removed, packaged and stored for future disposition. Interior surfaces (walls, floor, and ceiling) of the cell were then decontaminated to a radiation level that allowed entry without the use of protective clothing or respiratory protection

  10. DQO Summary Report for 324 and 327 Building Hot Cells D4 Project Waste Characterization

    Energy Technology Data Exchange (ETDEWEB)

    T.A. Lee

    2006-02-06

    This data quality objective (DQO) summary report provides the results of the DQO process conducted for waste characterization activities for the 324 and 327 Building hot cells decommission, deactivate, decontaminate, and demolish activities. This DQO summary report addresses the systems and processes related to the hot cells, air locks, vaults, tanks, piping, basins, air plenums, air ducts, filters, an adjacent elements that have high dose rates, high contamination levels, and/or suspect transuranic waste, which will require nonstandard D4 techniques.

  11. The phylogenetic analysis of tetraspanins projects the evolution of cell-cell interactions from unicellular to multicellular organisms.

    Science.gov (United States)

    Huang, Shengfeng; Yuan, Shaochun; Dong, Meiling; Su, Jing; Yu, Cuiling; Shen, Yang; Xie, Xiaojin; Yu, Yanhong; Yu, Xuesong; Chen, Shangwu; Zhang, Shicui; Pontarotti, Pierre; Xu, Anlong

    2005-12-01

    In animals, the tetraspanins are a large superfamily of membrane proteins that play important roles in organizing various cell-cell and matrix-cell interactions and signal pathways based on such interactions. However, their origin and evolution largely remain elusive and most of the family's members are functionally unknown or less known due to difficulties of study, such as functional redundancy. In this study, we rebuilt the family's phylogeny with sequences retrieved from online databases and our cDNA library of amphioxus. We reveal that, in addition to in metazoans, various tetraspanins are extensively expressed in protozoan amoebae, fungi, and plants. We also discuss the structural evolution of tetraspanin's major extracellular domain and the relation between tetraspanin's duplication and functional redundancy. Finally, we elucidate the coevolution of tetraspanins and eukaryotes and suggest that tetraspanins play important roles in the unicell-to-multicell transition. In short, the study of tetraspanin in a phylogenetic context helps us understand the evolution of intercellular interactions.

  12. Proceedings of the Flat-Plate Solar Array Project Workshop on Crystal Gowth for High-Efficiency Silicon Solar Cells

    Science.gov (United States)

    Dumas, K. A. (Editor)

    1985-01-01

    A Workshop on Crystal Growth for High-Efficiency Silicon Solar Cells was held December 3 and 4, 1984, in San Diego, California. The Workshop offered a day and a half of technical presentations and discussions and an afternoon session that involved a panel discussion and general discussion of areas of research that are necessary to the development of materials for high-efficiency solar cells. Topics included the theoretical and experimental aspects of growing high-quality silicon crystals, the effects of growth-process-related defects on photovoltaic devices, and the suitability of various growth technologies as cost-effective processes. Fifteen invited papers were presented, with a discussion period following each presentation. The meeting was organized by the Flat-Plate Solar Array Project of the Jet Propulsion Laboratory. These Proceedings are a record of the presentations and discussions, edited for clarity and continuity.

  13. A discrete dopaminergic projection from the incertohypothalamic A13 cell group to the dorsolateral periaqueductal gray in rat

    Directory of Open Access Journals (Sweden)

    Fany eMessanvi

    2013-12-01

    Full Text Available Several findings have indicated an involvement of dopamine in panic and defensive behaviors. The dorsolateral column of the periaqueductal gray (dlPAG is crucially involved in the expression of panic attacks in humans and defensive behaviors, also referred to as panic-like behaviors, in animals. Although the dlPAG is known to receive a specific innervation of dopaminergic fibers and abundantly expresses dopamine receptors, the origin of this dopaminergic input is largely unknown. This study aimed at mapping the dopaminergic projections to the dlPAG in order to provide further insight into the panic-like related behavior circuitry of the dlPAG. For this purpose, the retrograde tracer cholera toxin subunit b (CTb was injected into the dlPAG of male Wistar rats and double immunofluorescence for CTb and tyrosine hydroxylase (TH, the rate-limiting enzyme in the synthesis of dopamine, was performed. Neurons labeled for both CTb and TH were counted in different dopaminergic cell groups. The findings indicate that the dopaminergic nerve terminals present in the dlPAG originate from multiple dopamine-containing cell groups in the hypothalamus and mesencephalon. Interestingly, the A13 cell group is the main source of dopaminergic afferents to the dlPAG and contains at least 45% of the total number of CTb/TH-positive neurons. Anterograde tracing with biotinylated dextran amine (BDA combined with double immunofluorescence for BDA and TH confirmed the projections from the A13 cell group to the dlPAG. The remainder of the dopamine-positive terminals present in the dlPAG was found to originate from the extended A10 cell group and the A11 group. The A13 cell group is known to send dopaminergic efferents to several other brain regions implicated in defensive behavior, including the central amygdala and ventromedial hypothalamus. Therefore, although direct behavioral evidence is lacking, our finding that the A13 cell group is also the main source of dopaminergic

  14. Fluorescence Exclusion: A Simple Method to Assess Projected Surface, Volume and Morphology of Red Blood Cells Stored in Blood Bank

    Directory of Open Access Journals (Sweden)

    Camille Roussel

    2018-05-01

    Full Text Available Red blood cells (RBC ability to circulate is closely related to their surface area-to-volume ratio. A decrease in this ratio induces a decrease in RBC deformability that can lead to their retention and elimination in the spleen. We recently showed that a subpopulation of “small RBC” with reduced projected surface area accumulated upon storage in blood bank concentrates, but data on the volume of these altered RBC are lacking. So far, single cell measurement of RBC volume has remained a challenging task achieved by a few sophisticated methods some being subject to potential artifacts. We aimed to develop a reproducible and ergonomic method to assess simultaneously RBC volume and morphology at the single cell level. We adapted the fluorescence exclusion measurement of volume in nucleated cells to the measurement of RBC volume. This method requires no pre-treatment of the cell and can be performed in physiological or experimental buffer. In addition to RBC volume assessment, brightfield images enabling a precise definition of the morphology and the measurement of projected surface area can be generated simultaneously. We first verified that fluorescence exclusion is precise, reproducible and can quantify volume modifications following morphological changes induced by heating or incubation in non-physiological medium. We then used the method to characterize RBC stored for 42 days in SAG-M in blood bank conditions. Simultaneous determination of the volume, projected surface area and morphology allowed to evaluate the surface area-to-volume ratio of individual RBC upon storage. We observed a similar surface area-to-volume ratio in discocytes (D and echinocytes I (EI, which decreased in EII (7% and EIII (24%, sphero-echinocytes (SE; 41% and spherocytes (S; 47%. If RBC dimensions determine indeed the ability of RBC to cross the spleen, these modifications are expected to induce the rapid splenic entrapment of the most morphologically altered RBC

  15. The Value and Relevance of the T Cell Lymphoma Registries and International Collaborations: the Case of COMPLETE and the T-Cell Project.

    Science.gov (United States)

    Bellei, Monica; Nabhan, Chadi; Pesce, Emanuela Anna; Conte, Luana; Vose, Julie M; Foss, Francine; Federico, Massimo

    2015-12-01

    Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of lymphoid malignancies that portend a poor prognosis and have an undefined optimal therapeutic strategy. Data on best practices stem from prior studies that have generally included B cell lymphomas. However, the enhanced ability to diagnose PTCLs, the development of newer agents specific for PTCLs, and its increased incidence have called the scientific community to develop better strategies to combat these neoplasms. To that end, T cell lymphoma registries were developed in an attempt to answer relevant questions on the prognosis and management of PTCLs. The largest registries currently enrolling patients are the Comprehesive Oncology Measures for PeripheraL T-cEll Lymphoma TrEatment (COMPLETE) and the T-Cell Project. Despite the inherent limitations of these studies, valuable information are being collected to refine our management approaches and to aid in designing future clinical trials. This review illustrates the value of these registries and describes the critical questions that need to be answered.

  16. Project Plan 7930 Cell G PaR Remote Handling System Replacement

    International Nuclear Information System (INIS)

    Kinney, Kathryn A.

    2009-01-01

    For over 40 years the US Department of Energy (DOE) and its predecessors have made Californium-252 ( 252 Cf) available for a wide range of industries including medical, nuclear fuels, mining, military and national security. The Radiochemical Engineering Development Center (REDC) located within the Oak Ridge National Laboratory (ORNL) processes irradiated production targets from the High Flux Isotope Reactor (HFIR). Operations in Building 7930, Cell G provide over 70% of the world's demand for 252 Cf. Building 7930 was constructed and equipped in the mid-1960s. Current operations for 252 Cf processing in Building 7930, Cell G require use of through-the-wall manipulators and the PaR Remote Handling System. Maintenance and repairs for the manipulators is readily accomplished by removal of the manipulator and relocation to a repair shop where hands-on work can be performed in glove boxes. Contamination inside cell G does not currently allow manned entry and no provisions were created for a maintenance area inside the cell. There has been no maintenance of the PaR system or upgrades, leaving operations vulnerable should the system have a catastrophic failure. The Cell G PaR system is currently being operated in a run to failure mode. As the manipulator is now 40+ years old there is significant risk in this method of operation. In 2006 an assessment was completed that resulted in recommendations for replacing the manipulator operator control and power centers which are used to control and power the PaR manipulator in Cell G. In mid-2008 the chain for the bridge drive failed and subsequent examinations indicated several damaged links (see Figure 1). To continue operations the PaR manipulator arm is being used to push and pull the bridge as a workaround. A retrieval tool was fabricated, tested and staged inside Cell G that will allow positioning of the bridge and manipulator arm for removal from the cell should the PaR system completely fail. A fully functioning and

  17. Space Station Biological Research Project (SSBRP) Cell Culture Unit (CCU) and incubator for International Space Station (ISS) cell culture experiments

    Science.gov (United States)

    Vandendriesche, Donald; Parrish, Joseph; Kirven-Brooks, Melissa; Fahlen, Thomas; Larenas, Patricia; Havens, Cindy; Nakamura, Gail; Sun, Liping; Krebs, Chris; de Luis, Javier; hide

    2004-01-01

    The CCU and Incubator are habitats under development by SSBRP for gravitational biology research on ISS. They will accommodate multiple specimen types and reside in either Habitat Holding Racks, or the Centrifuge Rotor, which provides selectable gravity levels of up to 2 g. The CCU can support multiple Cell Specimen Chambers, CSCs (18, 9 or 6 CSCs; 3, 10 or 30 mL in volume, respectively). CSCs are temperature controlled from 4-39 degrees C, with heat shock to 45 degrees C. CCU provides automated nutrient supply, magnetic stirring, pH/O2 monitoring, gas supply, specimen lighting, and video microscopy. Sixty sample containers holding up to 2 mL each, stored at 4-39 degrees C, are available for automated cell sampling, subculture, and injection of additives and fixatives. CSCs, sample containers, and fresh/spent media bags are crew-replaceable for long-term experiments. The Incubator provides a 4-45 degrees C controlled environment for life science experiments or storage of experimental reagents. Specimen containers and experiment unique equipment are experimenter-provided. The Specimen Chamber exchanges air with ISS cabin and has 18.8 liters of usable volume that can accommodate six trays and the following instrumentation: five relocatable thermometers, two 60 W power outlets, four analog ports, and one each relative humidity sensor, video port, ethernet port and digital input/output port.

  18. My Dog's Cheeks: A PBL Project on Collagen for Cell Biology and Genetics Courses

    Science.gov (United States)

    Casla, Alberto Vicario; Zubiaga, Isabel Smith

    2010-01-01

    Students often have an oversimplified view of biological facts, which may hinder subsequent understanding when conceptual complexity gives rise to cognitive conflicts. To avoid this situation here, we present a PBL approach for the analysis of Ehlers-Danlos syndrome (EDS), which integrates a variety of topics in cell biology, genetics, and…

  19. Fuel Cell-Powered Go-Kart: Project Mimics Real-World Product Development

    Science.gov (United States)

    Fuller, Amanda

    2010-01-01

    Five years ago, Leon Strecker's technology education class at Darien High School came up with the idea of building a fuel cell-powered go-kart. In previous years, the class had worked on other creations, such as electric cars that competed in a state-sponsored race and a full-size hovercraft. But students had not taken on anything anywhere near…

  20. Follow up of test areas with FSS liners. Gaerstad and Sofielund landfills; Uppfoeljning av provytor med taetskikt av FSA. Gaerstad deponi och Sofielunds deponi

    Energy Technology Data Exchange (ETDEWEB)

    Laendell, Maerta; Carling, Maria; Haakansson, Karsten; Myrhede, Elke; Svensson, Bo

    2009-03-19

    In the coming years, a large number of landfills will be closed as a result of new environmental legislation and more stringent requirements. The availability of suitable material for covering and sealing is limited, especially in large urban areas. Sludge and ash are potentially useful materials for this purpose. The project 'Covering landfill with sludge and ash' was carried out from 2003 to 2005. The project involved the establishment and monitoring of different test areas having liners (sealing layers) of sewage sludge and fly ash. The experience gained from this project has also been used in the development of guidelines for using fly-ash-stabilised sewage sludge (FSS) as a liner. In the current project, two test areas have been monitored for a three-year period. Investigations have focused on the permeability of the materials, chemical properties of both runoff water and percolating water, resistance to decomposition, subsidence/compaction, strength, etc. The project was financed by Vaermeforsk, Svensk Vatten Utveckling and the two participating facilities (Tekniska Verken in Linkoeping and SRV Aatervinning in Huddinge). The study was carried out by Geo Innova in collaboration with both facilities, and the Department for Water and Environmental Studies at Linkoeping University. The project involved sampling and analysis of water, pore gas and solid material. In the field, subsidence and water levels have been measured. The results have been compared with the guideline levels for surface water, between different sampling and measurement locations (above and below the liner, with and without drainage, steep and flat areas, etc), and at different times. The results show that the FSS liner is impermeable. The requirement for landfills for non-hazardous waste is satisfied; in some cases the permeability is on a par with the requirement for hazardous waste landfills. Some decomposition of the material occurs, as indicated by the detection of methane and

  1. Two dimensional point of use fuel cell : a final LDRD project report.

    Energy Technology Data Exchange (ETDEWEB)

    Zavadil, Kevin Robert; Hickner, Michael A. (Pennsylvania State University, University Park, PA); Gross, Matthew L. (Pennsylvania State University, University Park, PA)

    2011-03-01

    The Proliferation Assessment (program area - Things Thin) within the Defense Systems and Assessment Investment Area desires high energy density and long-lived power sources with moderate currents (mA) that can be used as building blocks in platforms for the continuous monitoring of chemical, biological, and radiological agents. Fuel cells can be an optimum choice for a power source because of the high energy densities that are possible with liquid fuels. Additionally, power generation and fuel storage can be decoupled in a fuel cell for independent control of energy and power density for customized, application-driven power solutions. Direct methanol fuel cells (DMFC) are explored as a possible concept to develop into ultrathin or two-dimensional power sources. New developments in nanotechnology, advanced fabrication techniques, and materials science are exploited to create a planar DMFC that could be co-located with electronics in a chip format. Carbon nanotubes and pyrolyzed polymers are used as building block electrodes - porous, mechanically compliant current collectors. Directed assembly methods including surface functionalization and layer-by-layer deposition with polyelectrolytes are used to pattern, build, and add functionality to these electrodes. These same techniques are used to incorporate nanoscale selective electrocatalyst into the carbon electrodes to provide a high density of active electron transfer sites for the methanol oxidation and oxygen reduction reactions. The resulting electrodes are characterized in terms of their physical properties, electrocatalytic function, and selectivity to better understand how processing impacts their performance attributes. The basic function of a membrane electrode assembly is demonstrated for several prototype devices.

  2. D and D Toolbox Project - Technology Demonstration of Fixatives Applied to Hot Cell Facilities via Remote Sprayer Platforms

    International Nuclear Information System (INIS)

    Lagos, L.; Shoffner, P.; Espinosa, E.; Pena, G.; Kirk, P.; Conley, T.

    2009-01-01

    The objective of the US Department of Energy Office of Environmental Management's (DOE-EM's) D and D Toolbox Project is to use an integrated systems approach to develop a suite of decontamination and decommissioning (D and D) technologies, a D and D toolbox, that can be readily used across the DOE complex to improve safety, reduce technical risks, and limit uncertainty within D and D operations. Florida International University's Applied Research Center (FIU-ARC) is supporting this initiative by identifying technologies suitable to meet specific facility D and D requirements, assessing the readiness of those technologies for field deployment, and conducting technology demonstrations of selected technologies at FIU-ARC facilities in Miami, Florida. To meet the technology gap challenge for a technology to remotely apply strippable/fixative coatings, FIU-ARC identified and demonstrated of a remote fixative sprayer platform. During this process, FIU-ARC worked closely with the Oak Ridge National Laboratory in the selection of typical fixatives and in the design of a hot cell mockup facility for demonstrations at FIUARC. For this demonstration and for future demonstrations, FIU-ARC built a hot cell mockup facility at the FIU-ARC Technology Demonstration/Evaluation site in Miami, Florida. FIU-ARC selected the International Climbing Machines' (ICM's) Robotic Climber to perform this technology demonstration. The selected technology was demonstrated at the hot cell mockup facility at FIU-ARC during the week of November 10, 2008. Fixative products typically used inside hot cells were investigated and selected for this remote application. The fixatives tested included Sherwin Williams' Promar 200 and DTM paints and Bartlett's Polymeric Barrier System (PBS). The technology evaluation documented the ability of the remote system to spray fixative products on horizontal and vertical concrete surfaces. The technology performance, cost, and health and safety issues were evaluated

  3. In situ testing to determination field-saturated hydraulic conductivity of UMTRA Project disposal cell covers, liners, and foundation areas

    International Nuclear Information System (INIS)

    1994-02-01

    This special study was conducted to prepare a guidance document for selecting in situ hydraulic conductivity (K) tests, comparing in situ testing methods, and evaluating the results of such tests. This report may be used as a practical decision-making tool by the Uranium Mill Tailings Remedial Action (UMTRA) Project staff to determine which testing method will most efficiently achieve the field-saturated K results needed for long-term planning. A detailed section on near-surface test methods discusses each method which may be applicable to characterization of UMTRA disposal cell covers, liners and foundation materials. These potentially applicable test methods include the sealed double-ring infiltrometer (SDRI), the air-entry permeameter (AEP), the guelph permeameter, the two-stage borehole technique (TSB), the pressure infiltrometer, and the disk permeameter. Analytical solutions for these methods are provided, and limitations of these solutions are discussed, and a description of testing equipment design and installation are provided

  4. Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex.

    Science.gov (United States)

    Klein, Carsten; Evrard, Henry C; Shapcott, Katharine A; Haverkamp, Silke; Logothetis, Nikos K; Schmid, Michael C

    2016-04-06

    Electrical microstimulation and more recently optogenetics are widely used to map large-scale brain circuits. However, the neuronal specificity achieved with both methods is not well understood. Here we compare cell-targeted optogenetics and electrical microstimulation in the macaque monkey brain to functionally map the koniocellular lateral geniculate nucleus (LGN) projection to primary visual cortex (V1). Selective activation of the LGN konio neurons with CamK-specific optogenetics caused selective electrical current inflow in the supra-granular layers of V1. Electrical microstimulation targeted at LGN konio layers revealed the same supra-granular V1 activation pattern as the one elicited by optogenetics. Taken together, these findings establish a selective koniocellular LGN influence on V1 supra-granular layers, and they indicate comparable capacities of both stimulation methods to isolate thalamo-cortical circuits in the primate brain. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Final Report of Project Nanometer Structures for Fuel Cells and Displays, etc.

    Energy Technology Data Exchange (ETDEWEB)

    Ji, Qing

    2011-12-15

    Low-energy ion beam bombardment induced self-assembly has been used to form various periodic nano-size wave-ordered structures (WOS). Such WOS can be used as hard etching masks to produce nanowire arrays, trenches etc., on other materials by means of traditional etching or ion sputtering. These periodic nano-size structures have a wide range of applications, including flat panel displays, optical electronics, and clean energy technologies (solar and fuel cells, lithium batteries). In order to achieve high throughput of the above processes, a large area RF-driven multicusp nitrogen ion source has been developed for the application of nitrogen ion beam induced surface modification. An integrated ion beam system, which can house either a large area RF-driven multicusp ion source or a commercially available microwave ion source (Roth & Rau AG Tamiris 400-f) have been designed, manufactured, assembled, and tested.

  6. Vessel Cold-Ironing Using a Barge Mounted PEM Fuel Cell: Project Scoping and Feasibility.

    Energy Technology Data Exchange (ETDEWEB)

    Pratt, Joseph William [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Harris, Aaron P. [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2013-01-01

    A barge-mounted hydrogen-fueled proton exchange membrane (PEM) fuel cell system has the potential to reduce emissions and fossil fuel use of maritime vessels in and around ports. This study determines the technical feasibility of this concept and examines specific options on the U.S. West Coast for deployment practicality and potential for commercialization.The conceptual design of the system is found to be straightforward and technically feasible in several configurations corresponding to various power levels and run times.The most technically viable and commercially attractive deployment options were found to be powering container ships at berth at the Port of Tacoma and/or Seattle, powering tugs at anchorage near the Port of Oakland, and powering refrigerated containers on-board Hawaiian inter-island transport barges. Other attractive demonstration options were found at the Port of Seattle, the Suisun Bay Reserve Fleet, the California Maritime Academy, and an excursion vessel on the Ohio River.

  7. Chemomobilization: Overview of an Educational Quality Improvement Project for Recipients of Autologous Stem Cell Transplantation
.

    Science.gov (United States)

    Rivera, Zandra R; Nurse, Rachelle; Fellman, Bryan; Brunelle, Nicole; Brassil, Kelly J

    2017-08-01

    In preparation for an autologous stem cell transplantation, patients undergo chemomobilization; however, a dearth of standardized, evidence-based patient education on chemomobilization exists in the literature and in practice.
. The purpose of this quality improvement educational initiative is to identify an 
evidence-based approach to appraise the educational needs of patients and their caregivers and to enhance chemomobilization education. 
. A review of the literature related to chemomobilization was conducted, as well as an informal survey of educational practices at five 
National Cancer Institute-designated comprehensive cancer centers. A 14-item survey was administered to 50 patients who underwent chemomobilization to assess their educational needs, experiences, and preferences. 
. Patients prefer written information to review. Receiving verbal education from reliable healthcare providers in a structured format may enhance effective comprehension and retention. Patients identified timing, process, side effects, and expectations about chemomobilization as the most important topics to include in education.

  8. High power tests of the prototype 352 MHz beta 0.85 five cell cavity for the TRASCO project

    International Nuclear Information System (INIS)

    Chiaveri, E.; Losito, R.; Calatroni, S.

    2003-01-01

    The Five-cell beta 0.85 cavities built at CERN for the development of the TRASCO project is fully tested at the CERN SL-CT Test Bench. The cavity, built using the standard Niobium on Copper technique, was previously tested in a vertical cryostat, showing Qo and Field exceeding the design goal for the TRASCO Project (2.5x10 9 and 5.5 MV/m at 4.5 K). After the successful test we decided to check the performances of the cavity installed in a horizontal Cryostat and equipped with a LEP-II Type high power main coupler and HOM couplers. The cavity was equipped with the Helium Tank, Tuners and couplers at CERN and tested at the SL-CT facility at CERN under a collaboration agreement between INFN and CERN. The behavior of the fully equipped cavity substantially confirmed the results of the preliminary production tests in the vertical Cryostat. The quality factor at low field was substantially unchanged. No MP activity was detected confirming the soundness of the design and the quality of the surface treatment. (author)

  9. In-situ recording of ionic currents in projection neurons and Kenyon cells in the olfactory pathway of the honeybee.

    Directory of Open Access Journals (Sweden)

    Jan Kropf

    Full Text Available The honeybee olfactory pathway comprises an intriguing pattern of convergence and divergence: ~60.000 olfactory sensory neurons (OSN convey olfactory information on ~900 projection neurons (PN in the antennal lobe (AL. To transmit this information reliably, PNs employ relatively high spiking frequencies with complex patterns. PNs project via a dual olfactory pathway to the mushroom bodies (MB. This pathway comprises the medial (m-ALT and the lateral antennal lobe tract (l-ALT. PNs from both tracts transmit information from a wide range of similar odors, but with distinct differences in coding properties. In the MBs, PNs form synapses with many Kenyon cells (KC that encode odors in a spatially and temporally sparse way. The transformation from complex information coding to sparse coding is a well-known phenomenon in insect olfactory coding. Intrinsic neuronal properties as well as GABAergic inhibition are thought to contribute to this change in odor representation. In the present study, we identified intrinsic neuronal properties promoting coding differences between PNs and KCs using in-situ patch-clamp recordings in the intact brain. We found very prominent K+ currents in KCs clearly differing from the PN currents. This suggests that odor coding differences between PNs and KCs may be caused by differences in their specific ion channel properties. Comparison of ionic currents of m- and l-ALT PNs did not reveal any differences at a qualitative level.

  10. In-situ recording of ionic currents in projection neurons and Kenyon cells in the olfactory pathway of the honeybee.

    Science.gov (United States)

    Kropf, Jan; Rössler, Wolfgang

    2018-01-01

    The honeybee olfactory pathway comprises an intriguing pattern of convergence and divergence: ~60.000 olfactory sensory neurons (OSN) convey olfactory information on ~900 projection neurons (PN) in the antennal lobe (AL). To transmit this information reliably, PNs employ relatively high spiking frequencies with complex patterns. PNs project via a dual olfactory pathway to the mushroom bodies (MB). This pathway comprises the medial (m-ALT) and the lateral antennal lobe tract (l-ALT). PNs from both tracts transmit information from a wide range of similar odors, but with distinct differences in coding properties. In the MBs, PNs form synapses with many Kenyon cells (KC) that encode odors in a spatially and temporally sparse way. The transformation from complex information coding to sparse coding is a well-known phenomenon in insect olfactory coding. Intrinsic neuronal properties as well as GABAergic inhibition are thought to contribute to this change in odor representation. In the present study, we identified intrinsic neuronal properties promoting coding differences between PNs and KCs using in-situ patch-clamp recordings in the intact brain. We found very prominent K+ currents in KCs clearly differing from the PN currents. This suggests that odor coding differences between PNs and KCs may be caused by differences in their specific ion channel properties. Comparison of ionic currents of m- and l-ALT PNs did not reveal any differences at a qualitative level.

  11. Review of alternative residual contamination guides for the 324 Building B-Cell Cleanout Project. Phase 1

    International Nuclear Information System (INIS)

    Vargo, G.J.; Durham, J.S.; Brackenbush, L.W.

    1995-09-01

    This report provides a proposed residual contamination guide (RCG) for the 324 Building B-Cell Cleanout Project, Phase 1, at the Hanford Site. The RCG is expressed as a fraction of the amount of highly dispersible radioactive material that would result in offsite doses equal to the Pacific Northwest Laboratory radiological risk guidelines following the worst credible accident scenario for release of the holdup material. The proposed RCG is 10 -1 to 10 -2 of the PNL radiological risk guidelines. As part of the development of the RCG, a number of factors were considered. These include the need to provide an appropriate level of flexibility for other activities within the 324 Building that could contribute to the facility's overall radiological risk, uncertainties inherent in safety analyses, and the possible contribution of other 300 Area facilities to overall radiological risk. Because of these factors and the nature of the cleanout project, the RCG is expressed as a range rather than a point value. This report also provides guidance on determining conformance to the RCG, including inspection and measurement techniques, quality assurance requirements, and consideration of uncertainty

  12. Pitfalls and major issues in the histologic diagnosis of peripheral T-cell lymphomas: results of the central review of 573 cases from the T-Cell Project, an international, cooperative study.

    Science.gov (United States)

    Bellei, Monica; Sabattini, Elena; Pesce, Emanuela Anna; Ko, Young-Hyeh; Kim, Won Seog; Cabrera, Maria Elena; Martinez, Virginia; Dlouhy, Ivan; Paes, Roberto Pinto; Barrese, Tomas; Vassallo, Josè; Tarantino, Vittoria; Vose, Julie; Weisenburger, Dennis; Rüdiger, Thomas; Federico, Massimo; Pileri, Stefano

    2017-12-01

    Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of neoplasms that are derived from post-thymic lymphoid cells at different stages of differentiation with different morphological patterns, phenotypes and clinical presentations. PTCLs are highly diverse, reflecting the diverse cells from which they can originate and are currently sub-classified using World Health Organization (WHO) 2008 criteria. In 2006 the International T-Cell Lymphoma Project launched the T-Cell Project, building on the retrospective study previously carried on by the network, with the aim to prospectively collect accurate data to improve knowledge on this group of lymphomas. Based on previously published reports from International Study Groups it emerged that rendering a correct classification of PTCLs is quite difficult because the relatively low prevalence of these diseases results in a lack of confidence by most pathologists. This is the reason why the T-Cell Project requested the availability of diagnostic material from the initial biopsy of each patient registered in the study in order to have the initial diagnosis centrally reviewed by expert hematopathologists. In the present report the results of the review process performed on 573 cases are presented. Overall, an incorrect diagnosis was centrally recorded in 13.1% cases, including 8.5% cases centrally reclassified with a subtype eligible for the project and 4.6% cases misclassified and found to be disorders other than T-cell lymphomas; 2.1% cases were centrally classified as T-Cell disorders not included in the study population. Thus, the T-Cell Project confirmed the difficulties in providing an accurate classification when a diagnosis of PTCLs is suspected, singled out the major pitfalls that can bias a correct histologic categorization and confirmed that a centralized expert review with the application of adequate diagnostic algorithms is mandatory when dealing with these tumours. Copyright © 2016 John Wiley & Sons

  13. UPS Project for GSM base stations with a fuel cell (PEM fuel cell back-up system) - Final report; Projekt USV fuer GSM-Basisstationen mit BZ (PEM fuel cell back-up system) - Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Trachte, U.

    2007-07-01

    The University of applied sciences HTA Lucerne designed a prototype of an uninterruptible power supply (UPS) with Fuel Cell technology instead of lead-acid batteries and put it into operation. The delayed start-up of the Fuel Cell was bridged with ultra capacitor technology. In a first project stage the system was designed, assembled and tested in laboratory. In a second stage the installation was connected to a real base station of a telecommunication antenna and put to field tests for one year. The field test included monthly simulations of power failure with antenna load of about 2.4 kW as well as tests with external load up to 8.5 kW to establish the characteristic diagram. Hydrogen was provided by two 50 l pressure tanks. The full quantity of hydrogen secured a stand-alone operation of the Fuel Cell system for about 6 hours under antenna load. The results of the 101 grid-failure simulations demonstrate a very reliable start-up behaviour of the Fuel Cell System. Also during a real power failure due to a thunderstorm the installation provided the demanded power without any problem. The total duration of operation of the Fuel Cell during the field tests was 39 hours. No degradation could be noticed. The project takes place in collaboration with the industrial partners APC Industrial Systems, as a producer and market leader of UPS-Systems, and Swisscom Mobile AG, as a user of UPS-systems in telecommunications. Following the good results and in order to get more experience in long-term operation of the Fuel Cell system the tests will go on for two more years. (author)

  14. Expression of SPIG1 reveals development of a retinal ganglion cell subtype projecting to the medial terminal nucleus in the mouse.

    Directory of Open Access Journals (Sweden)

    Keisuke Yonehara

    Full Text Available Visual information is transmitted to the brain by roughly a dozen distinct types of retinal ganglion cells (RGCs defined by a characteristic morphology, physiology, and central projections. However, our understanding about how these parallel pathways develop is still in its infancy, because few molecular markers corresponding to individual RGC types are available. Previously, we reported a secretory protein, SPIG1 (clone name; D/Bsp120I #1, preferentially expressed in the dorsal region in the developing chick retina. Here, we generated knock-in mice to visualize SPIG1-expressing cells with green fluorescent protein. We found that the mouse retina is subdivided into two distinct domains for SPIG1 expression and SPIG1 effectively marks a unique subtype of the retinal ganglion cells during the neonatal period. SPIG1-positive RGCs in the dorsotemporal domain project to the dorsal lateral geniculate nucleus (dLGN, superior colliculus, and accessory optic system (AOS. In contrast, in the remaining region, here named the pan-ventronasal domain, SPIG1-positive cells form a regular mosaic and project exclusively to the medial terminal nucleus (MTN of the AOS that mediates the optokinetic nystagmus as early as P1. Their dendrites costratify with ON cholinergic amacrine strata in the inner plexiform layer as early as P3. These findings suggest that these SPIG1-positive cells are the ON direction selective ganglion cells (DSGCs. Moreover, the MTN-projecting cells in the pan-ventronasal domain are apparently composed of two distinct but interdependent regular mosaics depending on the presence or absence of SPIG1, indicating that they comprise two functionally distinct subtypes of the ON DSGCs. The formation of the regular mosaic appears to be commenced at the end of the prenatal stage and completed through the peak period of the cell death at P6. SPIG1 will thus serve as a useful molecular marker for future studies on the development and function of ON DSGCs.

  15. The Pan-European Reference Grid Developed in the ELECTRA Project for Deriving Innovative Observability Concepts in the Web-of-Cells Framework

    DEFF Research Database (Denmark)

    Marinelli, Mattia; Pertl, Michael; Rezkalla, Michel M.N.

    2016-01-01

    In the ELECTRA EU project, an innovative approach for frequency and voltage control is investigated, with reference to future power system scenarios characterized by massive amounts of distributed energy resources. A control architecture based on dividing the power system into a web of subsystems...... at system-wide scale. The methodology proposed in the task analyzes the system performance by investigating typical phenomena peculiar to each stability type and by developing observables necessary for the novel Web-of-Cells based control methods to operate properly at cell- and inter-cell level. Crucial...

  16. Vesicular glutamate transporter 2 (VGLUT2) is co-stored with PACAP in projections from the rat melanopsin-containing retinal ganglion cells

    DEFF Research Database (Denmark)

    Engelund, Anna Iversen; Fahrenkrug, Jan; Harrison, Adrian Paul

    2010-01-01

    The retinal ganglion cell layer of the eye comprises a subtype of cells characterized by their intrinsic photosensitivity and expression of melanopsin (ipRGCs). These cells regulate a variety of non-image-forming (NIF) functions such as light entrainment of circadian rhythms, acute suppression......-localized in their projections in the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus. We conclude that there is evidence to support the use of glutamate and PACAP as neurotransmitters in NIF photoperception by rat ipRGCs, and that these neurotransmitters are co-stored and probably...

  17. USDA-FSA-APFO Dugutak Ortho Mosaic

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — This data set contains imagery from the National Agricultural Imagery Program (NAIP). NAIP acquires digital ortho imagery during the agricultural growing seasons in...

  18. USDA-FSA-APFO Digital Ortho Mosaic

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — This data set contains imagery from the National Agricultural Imagery Program (NAIP). NAIP acquires digital ortho imagery during the agricultural growing seasons in...

  19. USDA-FSA-APFO Digital Ortho Mosaic

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Digital orthographic imagery datasets contain georeferenced images of the Earth's surface, collected by a sensor in which object displacement has been removed for...

  20. Farm Services Administration (FSA) Color Orthophotos 2002

    Data.gov (United States)

    Minnesota Department of Natural Resources — This data set contains photographic information obtained for the National Agricultural Imagery Program (NAIP) and is comprised of scanned photographs that were...

  1. Neurokinin B-producing projection neurons in the lateral stripe of the striatum and cell clusters of the accumbens nucleus in the rat.

    Science.gov (United States)

    Zhou, Ligang; Furuta, Takahiro; Kaneko, Takeshi

    2004-12-06

    Neurons producing preprotachykinin B (PPTB), the precursor of neurokinin B, constitute 5% of neurons in the dorsal striatum and project to the substantia innominata (SI) selectively. In the ventral striatum, PPTB-producing neurons are collected mainly in the lateral stripe of the striatum (LSS) and cell clusters of the accumbens nucleus (Acb). In the present study, we first examined the distribution of PPTB-immunoreactive neurons in rat ventral striatum and found that a large part of the PPTB-immunoreactive cell clusters was continuous to the LSS, but a smaller part was not. Thus, we divided the PPTB-immunoreactive cell clusters into the LSS-associated and non-LSS-associated ones. We next investigated the projection targets of the PPTB-producing ventral striatal neurons by combining immunofluorescence labeling and retrograde tracing. After injection of Fluoro-Gold into the basal component of the SI (SIb) and medial part of the interstitial nucleus of posterior limb of the anterior commissure, many PPTB-immunoreactive neurons were retrogradely labeled in the LSS-associated cell clusters and LSS, respectively. When the injection site included the ventral part of the sublenticular component of the SI(SIsl), retrogradely labeled neurons showed PPTB-immunoreactivity frequently in non-LSS-associated cell clusters. Furthermore, these PPTB-immunoreactive projections were confirmed by the double-fluorescence method after anterograde tracer injection into the ventral striatum containing the cell clusters. Since the dorsalmost part of the SIsl is known to receive strong inputs from PPTB-producing dorsal striatal neurons, the present results indicate that PPTB-producing ventral striatal neurons project to basal forebrain target regions in parallel with dorsal striatal neurons without significant convergence. 2004 Wiley-Liss, Inc.

  2. Project implementation plan: ASTD remote deployment

    International Nuclear Information System (INIS)

    CRASS, D.W.

    1999-01-01

    This document is the project implementation plan for the ASTD Remote Deployment Project. The Plan identifies the roles and responsibilities for the project and defines the integration between the ASTD Project and the B-Cell Cleanout Project

  3. Final Project Report: Development of Micro-Structural Mitigation Strategies for PEM Fuel Cells: Morphological Simulations and Experimental Approaches

    Energy Technology Data Exchange (ETDEWEB)

    Wessel, Silvia [Ballard Materials Products; Harvey, David [Ballard Materials Products

    2013-06-28

    The durability of PEM fuel cells is a primary requirement for large scale commercialization of these power systems in transportation and stationary market applications that target operational lifetimes of 5,000 hours and 40,000 hours by 2015, respectively. Key degradation modes contributing to fuel cell lifetime limitations have been largely associated with the platinum-based cathode catalyst layer. Furthermore, as fuel cells are driven to low cost materials and lower catalyst loadings in order to meet the cost targets for commercialization, the catalyst durability has become even more important. While over the past few years significant progress has been made in identifying the underlying causes of fuel cell degradation and key parameters that greatly influence the degradation rates, many gaps with respect to knowledge of the driving mechanisms still exist; in particular, the acceleration of the mechanisms due to different structural compositions and under different fuel cell conditions remains an area not well understood. The focus of this project was to address catalyst durability by using a dual path approach that coupled an extensive range of experimental analysis and testing with a multi-scale modeling approach. With this, the major technical areas/issues of catalyst and catalyst layer performance and durability that were addressed are: 1. Catalyst and catalyst layer degradation mechanisms (Pt dissolution, agglomeration, Pt loss, e.g. Pt in the membrane, carbon oxidation and/or corrosion). a. Driving force for the different degradation mechanisms. b. Relationships between MEA performance, catalyst and catalyst layer degradation and operational conditions, catalyst layer composition, and structure. 2. Materials properties a. Changes in catalyst, catalyst layer, and MEA materials properties due to degradation. 3. Catalyst performance a. Relationships between catalyst structural changes and performance. b. Stability of the three-phase boundary and its effect on

  4. The genetic interaction network of CCW12, a Saccharomyces cerevisiae gene required for cell wall integrity during budding and formation of mating projections

    Science.gov (United States)

    2011-01-01

    Background Mannoproteins construct the outer cover of the fungal cell wall. The covalently linked cell wall protein Ccw12p is an abundant mannoprotein. It is considered as crucial structural cell wall component since in baker's yeast the lack of CCW12 results in severe cell wall damage and reduced mating efficiency. Results In order to explore the function of CCW12, we performed a Synthetic Genetic Analysis (SGA) and identified genes that are essential in the absence of CCW12. The resulting interaction network identified 21 genes involved in cell wall integrity, chitin synthesis, cell polarity, vesicular transport and endocytosis. Among those are PFD1, WHI3, SRN2, PAC10, FEN1 and YDR417C, which have not been related to cell wall integrity before. We correlated our results with genetic interaction networks of genes involved in glucan and chitin synthesis. A core of genes essential to maintain cell integrity in response to cell wall stress was identified. In addition, we performed a large-scale transcriptional analysis and compared the transcriptional changes observed in mutant ccw12Δ with transcriptomes from studies investigating responses to constitutive or acute cell wall damage. We identified a set of genes that are highly induced in the majority of the mutants/conditions and are directly related to the cell wall integrity pathway and cell wall compensatory responses. Among those are BCK1, CHS3, EDE1, PFD1, SLT2 and SLA1 that were also identified in the SGA. In contrast, a specific feature of mutant ccw12Δ is the transcriptional repression of genes involved in mating. Physiological experiments substantiate this finding. Further, we demonstrate that Ccw12p is present at the cell periphery and highly concentrated at the presumptive budding site, around the bud, at the septum and at the tip of the mating projection. Conclusions The combination of high throughput screenings, phenotypic analyses and localization studies provides new insight into the function of Ccw

  5. Incorporation of (14)C-cholesterol in human adrenal corticocarcinoma H295R cell line and online-radiodetection of produced (14)C-steroid hormone metabolites

    DEFF Research Database (Denmark)

    Abdel-Khalik, Jonas; Björklund, Erland; Nielsen, Frederik Knud

    2017-01-01

    in the steroidogenesis of H295R cells, radioactive cholesterol may potentially only need to be added just before the cells are incubated for 72h in well plates. Based on the obtained HPLC-FSA chromatograms, and confirmation of the observations by studies in the literature, a qualitative time profile for the production......, the concept of radiolabeling the steroidogenesis in H295R cells with (14)C-cholesterol and detecting the radiolabeled steroid hormones online was proved and may assist in further toxicological studies....

  6. Towards a framework for evaluation of renewable energy storage projects: A study case of hydrogen and fuel cells in Denmark

    DEFF Research Database (Denmark)

    Tambo, Torben; Enevoldsen, Peter

    2015-01-01

    worldwide, and market potentials are projected as immense. RES is complicated, and projects persistently fail to present operational scale of operations except for a few “classical” storage technologies: Variants of lead-acid batteries and pumped hydro-power reservoirs. Most RES projects are relying...... trajectories as done today. The papers findings contribute to improved assessment of RES technologies by emphasizing risk reduction and operational viability....

  7. Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery

    Energy Technology Data Exchange (ETDEWEB)

    Song, Chang W., E-mail: songx001@umn.edu [Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, Minnesota (United States); Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Lee, Yoon-Jin [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Griffin, Robert J. [Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Park, Inhwan [Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, Minnesota (United States); Koonce, Nathan A. [Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Hui, Susanta [Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, Minnesota (United States); Kim, Mi-Sook [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Dusenbery, Kathryn E. [Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, Minnesota (United States); Sperduto, Paul W. [Minneapolis Radiation Oncology and Gamma Knife Center, University of Minnesota, Minneapolis, Minnesota (United States); Cho, L. Chinsoo [Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, Minnesota (United States)

    2015-09-01

    Purpose: The purpose of this study was to reveal the biological mechanisms underlying stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS). Methods and Materials: FSaII fibrosarcomas grown subcutaneously in the hind limbs of C3H mice were irradiated with 10 to 30 Gy of X rays in a single fraction, and the clonogenic cell survival was determined with in vivo–in vitro excision assay immediately or 2 to 5 days after irradiation. The effects of radiation on the intratumor microenvironment were studied using immunohistochemical methods. Results: After cells were irradiated with 15 or 20 Gy, cell survival in FSaII tumors declined for 2 to 3 days and began to recover thereafter in some but not all tumors. After irradiation with 30 Gy, cell survival declined continuously for 5 days. Cell survival in some tumors 5 days after 20 to 30 Gy irradiation was 2 to 3 logs less than that immediately after irradiation. Irradiation with 20 Gy markedly reduced blood perfusion, upregulated HIF-1α, and increased carbonic anhydrase-9 expression, indicating that irradiation increased tumor hypoxia. In addition, expression of VEGF also increased in the tumor tissue after 20 Gy irradiation, probably due to the increase in HIF-1α activity. Conclusions: Irradiation of FSaII tumors with 15 to 30 Gy in a single dose caused dose-dependent secondary cell death, most likely by causing vascular damage accompanied by deterioration of intratumor microenvironment. Such indirect tumor cell death may play a crucial role in the control of human tumors with SBRT and SRS.

  8. Social basis for solar cells on rented houses. Decision making in the PV-project in Heerhugowaard and the experiences of residents and neighbours

    International Nuclear Information System (INIS)

    Van Mierlo, B.; Van Roekel, A.; Westra, C.

    1994-11-01

    At the end of ten solar homes were officially opened in the newly built area Butterhuizen in Heerhugowaard, Netherlands. Those houses are provided with grid-connected solar cell systems on the roof to generate electricity that is supplied to the grid. The solar panels are owned by the regional energy utility (PEN) and allowed by the renter of the dwellings. In this report of the demonstration project three years of experiences and opinions of organizations and residents, involved in the project, are evaluated. The results give a first indication of the chances and constraints to apply solar cells in the housing construction in the Netherlands. 4 figs., 3 ills., 17 tabs., 13 refs., 3 appendices

  9. Comparative assessment of hydrogen storage and international electricity trade for a Danish energy system with wind power and hydrogen/fuel cell technologies. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Bent (Roskilde University, Energy, Environment and Climate Group, Dept. of Environmental, Social and Spatial Change (ENSPAC) (DK)); Meibom, P.; Nielsen, Lars Henrik; Karlsson, K. (Technical Univ. of Denmark, Risoe National Laboratory for Sustainable Energy, Systems Analysis Dept., Roskilde (DK)); Hauge Pedersen, A. (DONG Energy, Copenhagen (DK)); Lindboe, H.H.; Bregnebaek, L. (ea Energy Analysis, Copenhagen (DK))

    2008-02-15

    This report is the final outcome of a project carried out under the Danish Energy Agency's Energy Research Programme. The aims of the project can be summarized as follows: 1) Simulation of an energy system with a large share of wind power and possibly hydrogen, including economic optimization through trade at the Nordic power pool (exchange market) and/or use of hydrogen storage. The time horizon is 50 years. 2) Formulating new scenarios for situations with and without development of viable fuel cell technologies. 3) Updating software to solve the abovementioned problems. The project has identified a range of scenarios for all parts of the energy system, including most visions of possible future developments. (BA)

  10. In response to an open invitation for comments on AAAS project 2061's Benchmark books on science. Part 1: documentation of serious errors in cell biology.

    Science.gov (United States)

    Ling, Gilbert

    2006-01-01

    Project 2061 was founded by the American Association for the Advancement of Science (AAAS) to improve secondary school science education. An in-depth study of ten 9 to 12th grade biology textbooks led to the verdict that none conveyed "Big Ideas" that would give coherence and meaning to the profusion of lavishly illustrated isolated details. However, neither the Project report itself nor the Benchmark books put out earlier by the Project carries what deserves the designation of "Big Ideas." Worse, in the two earliest-published Benchmark books, the basic unit of all life forms--the living cell--is described as a soup enclosed by a cell membrane, that determines what can enter or leave the cell. This is astonishing since extensive experimental evidence has unequivocally disproved this idea 60 years ago. A "new" version of the membrane theory brought in to replace the discredited (sieve) version is the pump model--currently taught as established truth in all high-school and college biology textbooks--was also unequivocally disproved 40 years ago. This comment is written partly in response to Bechmark's gracious open invitation for ideas to improve the books and through them, to improve US secondary school science education.

  11. Microchannel-connected SU-8 honeycombs by single-step projection photolithography for positioning cells on silicon oxide nanopillar arrays

    International Nuclear Information System (INIS)

    Larramendy, Florian; Paul, Oliver; Blatche, Marie Charline; Mazenq, Laurent; Laborde, Adrian; Temple-Boyer, Pierre

    2015-01-01

    We report on the fabrication, functionalization and testing of SU-8 microstructures for cell culture and positioning over large areas. The microstructure consists of a honeycomb arrangement of cell containers interconnected by microchannels and centered on nanopillar arrays designed for promoting cell positioning. The containers have been dimensioned to trap single cells and, with a height of 50 µm, prevent cells from escaping. The structures are fabricated using a single ultraviolet photolithography exposure with focus depth in the lower part of the SU-8 resist. With optimized process parameters, microchannels of various aspect ratios are thus produced. The cell containers and microchannels serve for the organization of axonal growth between neurons. The roughly 2 µm-high and 500 nm-wide nanopillars are made of silicon oxide structured by deep reactive ion etching. In future work, beyond their cell positioning purpose, the nanopillars could be functionalized as sensors. The proof of concept of the novel microstructure for organized cell culture is given by the successful growth of interconnected PC12 cells. Promoted by the honeycomb geometry, a dense network of interconnections between the cells has formed and the intended intimate contact of cells with the nanopillar arrays was observed by scanning electron microscopy. This proves the potential of these new devices as tools for the controlled cell growth in an interconnected container system with well-defined 3D geometry. (paper)

  12. Flat-plate solar array project. Volume 6: Engineering sciences and reliability

    Science.gov (United States)

    Ross, R. G., Jr.; Smokler, M. I.

    1986-01-01

    The Flat-Plate Solar Array (FSA) Project activities directed at developing the engineering technology base required to achieve modules that meet the functional, safety, and reliability requirements of large scale terrestrial photovoltaic systems applications are reported. These activities included: (1) development of functional, safety, and reliability requirements for such applications; (2) development of the engineering analytical approaches, test techniques, and design solutions required to meet the requirements; (3) synthesis and procurement of candidate designs for test and evaluation; and (4) performance of extensive testing, evaluation, and failure analysis of define design shortfalls and, thus, areas requiring additional research and development. A summary of the approach and technical outcome of these activities are provided along with a complete bibliography of the published documentation covering the detailed accomplishments and technologies developed.

  13. Incorporation of 14C-cholesterol in human adrenal corticocarcinoma H295R cell line and online-radiodetection of produced 14C-steroid hormone metabolites

    DEFF Research Database (Denmark)

    Abdel-Khalik, Jonas; Björklund, Erland; Nielsen, Frederik Knud

    2017-01-01

    in the steroidogenesis of H295R cells, radioactive cholesterol may potentially only need to be added just before the cells are incubated for 72h in well plates. Based on the obtained HPLC-FSA chromatograms, and confirmation of the observations by studies in the literature, a qualitative time profile for the production......, the concept of radiolabeling the steroidogenesis in H295R cells with (14)C-cholesterol and detecting the radiolabeled steroid hormones online was proved and may assist in further toxicological studies....

  14. UMTRA Project remedial action planning and disposal cell design to comply with the proposed EPA [Environmental Protection Agency] standards (40 CFR Part 192)

    International Nuclear Information System (INIS)

    1989-01-01

    The Uranium Mill Tailings Remedial Action (UMTRA) Project involves stabilizing 24 inactive uranium mill tailings piles in 10 states. Remedial work must meet standards established by the US Environmental Protection Agency (EPA). Remedial action must be designed and constructed to prevent dispersion of the tailings and other contaminated materials, and must prevent the inadvertent use of the tailings by man. This report is prepared primarily for distribution to parties involved in the UMTRA Project, including the US Nuclear Regulatory Commission (NRC), and states and tribes. It is intended to record the work done by the DOE since publication of the proposed EPA groundwater protection standards, and to show how the DOE has attempted to respond and react in a positive way to the new requirements that result from the proposed standards. This report discusses the groundwater compliance strategies now being defined and implemented by the DOE, and details the changes in disposal cell designs that result from studies to evaluate ways to facilitate compliance with the proposed EPA groundwater protection standards. This report also serves to record the technical advances, planning, and progress made on the UMTRA Project since the appearance of the proposed EPA groundwater protection standards. The report serves to establish, document, and disseminate technical approaches and engineering and groundwater information to people who may be interested or involved in similar or related projects. 24 refs., 27 figs., 8 tabs

  15. Recent progress of national banking project on homozygous HLA-typed induced pluripotent stem cells in South Korea.

    Science.gov (United States)

    Rim, Yeri Alice; Park, Narae; Nam, Yoojun; Ham, Dong-Sik; Kim, Ji-Won; Ha, Hye-Yeong; Jung, Ji-Won; Jung, Seung Min; Baek, In Cheol; Kim, Su-Yeon; Kim, Tai-Gyu; Song, Jihwan; Lee, Jennifer; Park, Sung-Hwan; Chung, Nak-Gyun; Yoon, Kun-Ho; Ju, Ji Hyeon

    2018-03-01

    Induced pluripotent stem cells (iPSCs) can be generated by introducing several factors into mature somatic cells. Banking of iPSCs can lead to wider application for treatment and research. In an economical view, it is important to store cells that can cover a high percentage of the population. Therefore, the use of homozygous human leukocyte antigen-iPSCs (HLA-iPSCs) is thought as a potential candidate for effective iPSC banking system for further clinical use. We screened the database stored in the Catholic Hematopoietic Stem Cell Bank of Korea and sorted the most frequent homozygous HLA types of the South Korean population. Blood cells with the selected homozygous HLA types were obtained and transferred to the GMP facility in the Catholic Institute of Cell Therapy. Cells were reprogrammed to iPSCs inside the facility and went through several quality controls. As a result, a total of 13 homozygous GMP-grade iPSC lines were obtained in the facility. The generated iPSCs showed high pluripotency and normal karyotype after reprogramming. Five HLA-homozygous iPSCs had the type that was included in the top five most frequent HLA types. Homozygous HLA-iPSCs can open a new opportunity for further application of iPSCs in clinical research and therapy. Copyright © 2017 John Wiley & Sons, Ltd.

  16. Decontamination of hot cells K-1, K-3, M-1, M-3, and A-1, M-Wing, Building 200: Project final report Argonne National Laboratory-East

    International Nuclear Information System (INIS)

    Cheever, C.L.; Rose, R.W.

    1996-09-01

    The purpose of this project was to remove radioactively contaminated materials and equipment from the hot cells, to decontaminate the hot cells, and to dispose of the radioactive waste. The goal was to reduce stack releases of Rn-220 and to place the hot cells in an emptied, decontaminated condition with less than 10 microSv/h (1 mrem/h) general radiation background. The following actions were needed: organize and mobilize a decontamination team; prepare decontamination plans and procedures; perform safety analyses to ensure protection of the workers, public, and environment; remotely size-reduce, package, and remove radioactive materials and equipment for waste disposal; remotely decontaminate surfaces to reduce hot cell radiation background levels to allow personnel entries using supplied air and full protective suits; disassemble and package the remaining radioactive materials and equipment using hands-on techniques; decontaminate hot cell surfaces to remove loose radioactive contaminants and to attain a less than 10 microSv/h (1 mrem/h) general background level; document and dispose of the radioactive and mixed waste; and conduct a final radiological survey

  17. Process research of non-cz silicon material. Low cost solar array project, cell and module formation research area

    Science.gov (United States)

    1982-01-01

    Liquid diffusion masks and liquid applied dopants to replace the CVD Silox masking and gaseous diffusion operations specified for forming junctions in the Westinghouse baseline process sequence for producing solar cells from dendritic web silicon were investigated.

  18. Hijacked then lost in translation: the plight of the recombinant host cell in membrane protein structural biology projects.

    Science.gov (United States)

    Bill, Roslyn M; von der Haar, Tobias

    2015-06-01

    Membrane protein structural biology is critically dependent upon the supply of high-quality protein. Over the last few years, the value of crystallising biochemically characterised, recombinant targets that incorporate stabilising mutations has been established. Nonetheless, obtaining sufficient yields of many recombinant membrane proteins is still a major challenge. Solutions are now emerging based on an improved understanding of recombinant host cells; as a 'cell factory' each cell is tasked with managing limited resources to simultaneously balance its own growth demands with those imposed by an expression plasmid. This review examines emerging insights into the role of translation and protein folding in defining high-yielding recombinant membrane protein production in a range of host cells. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  19. Early Detection of Baby-Rain-Cell Aloft in a Severe Storm and Risk Projection for Urban Flash Flood

    Directory of Open Access Journals (Sweden)

    Eiichi Nakakita

    2017-01-01

    Full Text Available In July 2008, five people were killed by a tragic flash flood caused by a local torrential heavy rainfall in a short time in Toga River. From this tragic accident, we realized that a system which can detect hazardous rain-cells in the earlier stage is strongly needed and would provide an additional 5 to 10 min for evacuation. By analyzing this event, we verified that a first radar echo aloft, by volume scan observation, is a practical and important sign for early warning of flash flood, and we named a first echo as a “baby-rain-cell” of Guerrilla-heavy rainfall. Also, we found a vertical vorticity criterion for identifying hazardous rain-cells and developed a heavy rainfall prediction system that has the important feature of not missing any hazardous rain-cell. Being able to detect heavy rainfall by 23.6 min on average before it reaches the ground, this system is implemented in XRAIN in the Kinki area. Additionally, to resolve the relationship between baby-rain-cell growth and vorticity behavior, we carried out an analysis of vorticity inside baby-rain-cells and verified that a pair of positive and negative vertical vortex tubes as well as an updraft between them existed in a rain-cell in the early stage.

  20. Three-dimensional gyrokinetic particle-in-cell simulation of plasmas on a massively parallel computer: Final report on LDRD Core Competency Project, FY 1991--FY 1993

    International Nuclear Information System (INIS)

    Byers, J.A.; Williams, T.J.; Cohen, B.I.; Dimits, A.M.

    1994-01-01

    One of the programs of the Magnetic fusion Energy (MFE) Theory and computations Program is studying the anomalous transport of thermal energy across the field lines in the core of a tokamak. We use the method of gyrokinetic particle-in-cell simulation in this study. For this LDRD project we employed massively parallel processing, new algorithms, and new algorithms, and new formal techniques to improve this research. Specifically, we sought to take steps toward: researching experimentally-relevant parameters in our simulations, learning parallel computing to have as a resource for our group, and achieving a 100 x speedup over our starting-point Cray2 simulation code's performance

  1. Low cost solar array project. Cell and module formation research area. Process research of non-CZ silicon material

    Science.gov (United States)

    1983-01-01

    Liquid diffusion masks and liquid dopants to replace the more expensive CVD SiO2 mask and gaseous diffusion processes were investigated. Silicon pellets were prepared in the silicon shot tower; and solar cells were fabricated using web grown where the pellets were used as a replenishment material. Verification runs were made using the boron dopant and liquid diffusion mask materials. The average of cells produced in these runs was 13%. The relationship of sheet resistivity, temperature, gas flows, and gas composition for the diffusion of the P-8 liquid phosphorus solution was investigated. Solar cells processed from web grown from Si shot material were evaluated, and results qualified the use of the material produced in the shot tower for web furnace feed stock.

  2. Decontamination Project for Cell G of the Metal Recovery Facility at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    Mandry, G.J.; Grisham, R.W.

    1994-02-01

    The goal of the decontamination effort in Cell G at the Metal Recovery Facility, Building 3505, located at the Oak Ridge National Laboratory, was two-fold: to determine the effectiveness of the dry decontamination technique employed and to provide data required to assess whether additional decontamination using this method would be beneficial in the eventual decommissioning of the facility. Allied Technology Group (ATG) was contracted to remove a portion of the concrete surface in Cell G by a technique known as scabbling. Some metallic cell components were also scabbled to remove paint and other surface debris. Generally, the scabbling operation was a success. Levels of contamination were greatly reduced. The depth of contaminant penetration into the concrete surfaces of certain areas was much greater than had been anticipated, necessitating the removal of additional concrete and extending ATG's period of performance. Scabbling and other related techniques will be extremely useful in the decontamination and decommissioning of other nuclear facilities with similar radiological profiles

  3. Repair and cell-cycle response in cells exposed to environmental biohazards. Comprehensive project report, June 1, 1979-May 31, 1982

    International Nuclear Information System (INIS)

    Billen, D.

    1982-01-01

    Agents which cause damage to DNA leading to inhibition of DNA synthesis or faulty DNA replication or repair may cause cell death or mutation. Many organisms possess the ability to circumvent some or all of this DNA damage. Many DNA mutants of E. coli and B. subtilis provide a genetic approach to measuring the role of individual components of the DNA repair and replicative system. The information obtained with prokaryotes provides leads to assess the details of DNA repair and replication in mammalian systems including man. Escherichia coli cells treated with a low concentration of toluene become permeable to a variety of compounds, including the precursors and cofactors necessary for DNA synthesis. By their manipulation various aspects of DNA replication and repair can be selectively emphasized. Observations made by use of this system include: (1) Repair synthesis induced by x irradiation or exposure to alkylating chemicals of toluene-treated cells is more extensive if polynucleotide ligase is inhibited. (2) DNA replication in E. coli is carried out by DNA polymerase III. The replication of DNA is strongly inhibited by methylmethansulfonate, N-methyl-N-nitrosourea, and N-methyl-N'-nitro-N-nitrosoguanidine. (3) Using a po1A1 po1B100 dnaB (po1I - , po1II - , po1III + ) mutant of E. coli, it was demonstrated that the dnaB gene product is not necessary for Po1III directed repair synthesis. (4) The physiological stage of cells and tissues affects their response to environmental hazards. (5) Procedures for permeabilizing mammalian cells have been developed or further refined; and (6) In earlier studies involving both alkylating agents and x rays, it was observed that the number of DNA single-strand breaks increased with dose along with repair synthesis. It appears that non-repaired sites do not serve as primer ends for Po1I-dependent repair synthesis in toluene-treated cells

  4. South African hydrogen infrastructure (HySA infrastructure) for fuel cells and energy storage: Overview of a projects portfolio

    CSIR Research Space (South Africa)

    Bessarabov, D

    2017-05-01

    Full Text Available The paper provides brief introduction to the National South African Program, branded HySA (Hydrogen South Africa) as well as discusses potential business cases for deployment of hydrogen and fuel cell technology in South Africa. This paper also...

  5. Project Notes

    Science.gov (United States)

    School Science Review, 1978

    1978-01-01

    Presents sixteen project notes developed by pupils of Chipping Norton School and Bristol Grammar School, in the United Kingdom. These Projects include eight biology A-level projects and eight Chemistry A-level projects. (HM)

  6. Final technical report for project titled Quantitative Characterization of Cell Aggregation/Adhesion as Predictor for Distribution and Transport of Microorganisms in Subsurface Environment

    Energy Technology Data Exchange (ETDEWEB)

    Gu, April Z. [Northeastern Univ., Boston, MA (United States); Wan, Kai-tak [Northeastern Univ., Boston, MA (United States)

    2014-09-02

    This project aims to explore and develop enabling methodology and techniques for nano-scale characterization of microbe cell surface contact mechanics, interactions and adhesion quantities that allow for identification and quantification of indicative properties related to microorganism migration and transport behavior in porous media and in subsurface environments. Microbe transport has wide impact and therefore is of great interest in various environmental applications such as in situ or enhanced subsurface bioremediation,filtration processes for water and wastewater treatments and protection of drinking water supplies. Although great progress has been made towards understanding the identities and activities of these microorganisms in the subsurface, to date, little is known of the mechanisms that govern the mobility and transport of microorganisms in DOE’s contaminated sites, making the outcomes of in situ natural attenuation or contaminant stability enhancement unpredictable. Conventionally, movement of microorganisms was believed to follows the rules governing solute (particle) transport. However, recent studies revealed that cell surface properties, especially those pertaining to cell attachment/adhesion and aggregation behavior, can cause the microbe behavior to deviate from non-viable particles and hence greatly influence the mobility and distribution of microorganisms in porous media.This complexity highlights the need to obtain detailed information of cell-cell and cell-surface interactions in order to improve and refine the conceptual and quantitative model development for fate and transport of microorganisms and contaminant in subsurface. Traditional cell surface characterization methods are not sufficient to fully predict the deposition rates and transport behaviors of microorganism observed. A breakthrough of methodology that would allow for quantitative and molecular-level description of intrinsic cell surface properties indicative for cell

  7. The AMERE project: Enabling real-time detection of radiation effects in individual cells in deep space

    Science.gov (United States)

    De Vos, Winnok H.; Meesen, Geert; Szpirer, Cedric; Scohy, Sophie; Cherukuri, Chaitanya; Evrard, Olivier; Hutsebaut, Xavier; Beghuin, Didier

    2012-12-01

    A major concern for long-term deep space missions is the detrimental impact of cosmic radiation on human health. Especially the presence of high-energy particles of high atomic mass (HZE) represents a serious threat. To contribute to a fundamental understanding of space radiation effects and to help improving risk assessment for humans on the Moon, the ESA Lunar Lander mission model payload includes a package dedicated to cell-based radiobiology experiments in the form of an Autonomous Microscope for Examination of Radiation Effects (AMERE). The purpose of this setup is to enable real-time visualization of DNA damage repair in living cells after traversal of HZE particles on the Moon. To assess the feasibility of this challenging experiment, we have analysed the biological and technological demands. In this article, we discuss the experimental concept, the biological considerations and describe the implications for system design.

  8. Development of technique for AR coating and nickel and copper metallization of solar cells: FPS project, product development

    Science.gov (United States)

    Rominger, C. G.

    1981-01-01

    Silicon nitride and nickel pastes are investigated in conjunction with a brush copper plating process for the purpose of identifying one or more fabrication sequences which yield at least 10 percent efficient N(+)/P(+) flat plate solar cells. The adhesion of all nickel pastes is reduced significantly when subjected to acidic and alkaline brush copper plating solutions as a result of a combination of thermally induced stress and chemical attack of the frit, which occurs at the interface with the silicon solar cell. The AgF is penetrating the 800 a of Si3N4 and ohmic contact is occurring at all fire-in tempertures. During the brush plating process, fingers and buss bars tend to spread.

  9. Low cost solar array project cell and module formation research area: Process research of non-CZ silicon material

    Science.gov (United States)

    1981-01-01

    Liquid diffusion masks and liquid applied dopants to replace the CVD Silox masking and gaseous diffusion operations specified for forming junctions in the Westinghouse baseline process sequence for producing solar cells from dendritic web silicon were investigated. The baseline diffusion masking and drive processes were compared with those involving direct liquid applications to the dendritic web silicon strips. Attempts were made to control the number of variables by subjecting dendritic web strips cut from a single web crystal to both types of operations. Data generated reinforced earlier conclusions that efficiency levels at least as high as those achieved with the baseline back junction formation process can be achieved using liquid diffusion masks and liquid dopants. The deliveries of dendritic web sheet material and solar cells specified by the current contract were made as scheduled.

  10. Data Mining Approaches for Genomic Biomarker Development: Applications Using Drug Screening Data from the Cancer Genome Project and the Cancer Cell Line Encyclopedia.

    Directory of Open Access Journals (Sweden)

    David G Covell

    Full Text Available Developing reliable biomarkers of tumor cell drug sensitivity and resistance can guide hypothesis-driven basic science research and influence pre-therapy clinical decisions. A popular strategy for developing biomarkers uses characterizations of human tumor samples against a range of cancer drug responses that correlate with genomic change; developed largely from the efforts of the Cancer Cell Line Encyclopedia (CCLE and Sanger Cancer Genome Project (CGP. The purpose of this study is to provide an independent analysis of this data that aims to vet existing and add novel perspectives to biomarker discoveries and applications. Existing and alternative data mining and statistical methods will be used to a evaluate drug responses of compounds with similar mechanism of action (MOA, b examine measures of gene expression (GE, copy number (CN and mutation status (MUT biomarkers, combined with gene set enrichment analysis (GSEA, for hypothesizing biological processes important for drug response, c conduct global comparisons of GE, CN and MUT as biomarkers across all drugs screened in the CGP dataset, and d assess the positive predictive power of CGP-derived GE biomarkers as predictors of drug response in CCLE tumor cells. The perspectives derived from individual and global examinations of GEs, MUTs and CNs confirm existing and reveal unique and shared roles for these biomarkers in tumor cell drug sensitivity and resistance. Applications of CGP-derived genomic biomarkers to predict the drug response of CCLE tumor cells finds a highly significant ROC, with a positive predictive power of 0.78. The results of this study expand the available data mining and analysis methods for genomic biomarker development and provide additional support for using biomarkers to guide hypothesis-driven basic science research and pre-therapy clinical decisions.

  11. Achievement report on research and development in the Sunshine Project in fiscal 1980. Research on fuel cells (Research on aqueous alkaline solution electrolyte fuel cells); 1980 nendo nenryo denchi no kenkyu seika hokokusho. Arukari suiyoeki denkaishitsu nenryo denchi no kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1981-03-01

    This paper describes the achievements in fiscal 1980 in the Sunshine Project on developing aqueous alkaline solution electrolyte fuel cells. The oxygen electrode is a silver catalyst electrode using as carriers carbon lack and graphite powders having good corrosion resistance. A continuous discharge test was performed on the electrode for 3,000 hours. Furnace black having large surface area and naturally colloidal graphite showed stable performance. The hydrogen electrode, which is a catalyst electrode made of Raney-Ni containing third elements was given a 3000-hour continuous discharge test, where Zr addition presented stable performance. Activated carbon was found a good carrier in platinum added electrodes. For electrodes operating under high pressure gases, electrodes attached with sintered nickel film are suitable. With regard to prototype cells, laminated cells with high volume efficiency structured mainly with gasket seals were designed and fabricated. The IV characteristics measurement and continuous discharge test thereon revealed no functional problems. Furthermore, cells having electrode area of 100 cm{sup 2} and using bipolar sheets made of carbon were verified capable of withstanding 2000-hour continuous discharge. A non-conductive resin mold was proposed to prevent electrolytic corrosion of the carbon sheets. Discussions were given also on corrosion resistance of bonding agents. (NEDO)

  12. Image and diagnosis quality of X-ray image transmission via cell phone camera: a project study evaluating quality and reliability.

    Directory of Open Access Journals (Sweden)

    Hans Goost

    Full Text Available INTRODUCTION: Developments in telemedicine have not produced any relevant benefits for orthopedics and trauma surgery to date. For the present project study, several parameters were examined during assessment of x-ray images, which had been photographed and transmitted via cell phone. MATERIALS AND METHODS: A total of 100 x-ray images of various body regions were photographed with a Nokia cell phone and transmitted via email or MMS. Next, the transmitted photographs were reviewed on a laptop computer by five medical specialists and assessed regarding quality and diagnosis. RESULTS: Due to their poor quality, the transmitted MMS images could not be evaluated and this path of transmission was therefore excluded. Mean size of transmitted x-ray email images was 394 kB (range: 265-590 kB, SD ± 59, average transmission time was 3.29 min ± 8 (CI 95%: 1.7-4.9. Applying a score from 1-10 (very poor - excellent, mean image quality was 5.8. In 83.2 ± 4% (mean value ± SD of cases (median 82; 80-89%, there was agreement between final diagnosis and assessment by the five medical experts who had received the images. However, there was a markedly low concurrence ratio in the thoracic area and in pediatric injuries. DISCUSSION: While the rate of accurate diagnosis and indication for surgery was high with a concurrence ratio of 83%, considerable differences existed between the assessed regions, with lowest values for thoracic images. Teleradiology is a cost-effective, rapid method which can be applied wherever wireless cell phone reception is available. In our opinion, this method is in principle suitable for clinical use, enabling the physician on duty to agree on appropriate measures with colleagues located elsewhere via x-ray image transmission on a cell phone.

  13. ENVISION Project

    CERN Multimedia

    Ballantine, A; Dixon-Altaber, H; Dosanjh, M; Kuchina, L

    2011-01-01

    Hadrontherapy is a highly advanced technique of cancer radiotherapy that uses beams of charged particles (ions) to destroy tumour cells. While conventional X-rays traverse the human body depositing radiation as they pass through, ions deliver most of their energy at one point. Hadrontherapy is most advantageous once the position of the tumour is accurately known, so that healthy tissues can be protected. Accurate positioning is a crucial challenge for targeting moving organs, as in lung cancer, and for adapting the irradiation as the tumour shrinks with treatment. Therefore, quality assurance becomes one of the most relevant issues for an effective outcome of the cancer treatment. In order to improve the quality assurance tools for hadrontherapy, the European Commission is funding ENVISION, a 4-year project that aims at developing solutions for: real-• time non invasive monitoring • quantitative imaging • precise determination of delivered dose • fast feedback for optimal treatment planning • real-t...

  14. Development of technique for AR coating and nickel and copper metallization of solar cells. FPS Project: Product development

    Science.gov (United States)

    Taylor, W.

    1982-01-01

    Printed nickel overplated with copper and applied on top of a predeposited silicon nitride antireflective coating system for metallizing solar cells was analyzed. The ESL D and E paste formulations, and the new formulations F, G, H, and D-1 were evaluated. The nickel thick films were tested after firing for stability in the cleaning and plating solutions used in the Vanguard-Pacific brush plating process. It was found that the films are very sensitive to the leaning and alkaline copper solutions. Less sensitivity was displayed to the neutral copper solution. Microscopic and SEM observations show segregation of frit at the silicon nitride thick film interface with loose frit residues after lifting off plated grid lines.

  15. In vitro sensitivity of granulo-monocytic progenitors as a new toxicological cell system and endpoint in the ACuteTox Project

    International Nuclear Information System (INIS)

    Cerrato, Laura; Valeri, Antonio; Bueren, Juan A.; Albella, Beatriz

    2009-01-01

    The ACuteTox Project (part of the EU 6th Framework Programme) was started up in January 2005. The aim of this project is to develop a simple and robust in vitro strategy for prediction of human acute systemic toxicity, which could replace animal tests used for regulatory purposes. Our group is responsible for the characterization of the effect of the reference chemicals on the hematopoietic tissue. CFU-GM assay based on the culture of human mononuclear cord blood cells has been used to characterize the effects of the selected compounds on the myeloid progenitors. Previous results have shown the relevance of the CFU-GM assay for the prediction of human acute neutropenia after treatment of antitumoral compounds, and this assay has been recently approved by the ECVAM's Scientific Advisory Committee. Among the compounds included in the study there were pharmaceuticals, environmental pollutants and industrial chemicals. Eleven out of 55 chemicals did not show any cytotoxic effect at the maximum concentration tested. The correlation coefficients of CFU-GM IC50, IC70 and IC90 values with human LC50 values (50% lethal concentration calculated from time-related sublethal and lethal human blood concentrations) were 0.4965, 0.5106 and 0.5142 respectively. Although this correlation is not improve respect to classical in vitro basal cytotoxicity tests such as 3T3 Neutral Red Uptake, chemicals which deviate substantially in the correlation with these assays (colchicine, digoxin, 5-Fluorouracil and thallium sulfate) fitted very well in the linear regression analysis of the CFU-GM progenitors. The results shown in the present study indicate that the sensitivity of CFU-GM progenitors correlates better than the sensitivity of HL-60 cells with human LC50 values and could help to refine the predictability for human acute systemic toxicity when a given chemical may affect to the hematopoietic myeloid system.

  16. PEM fuel cells for mobile applications. Project part: Membrane development. Final report; PEM-Brennstoffzellen fuer mobile Anwendungen. Teilprojekt: Membranentwicklung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Frank, G

    1999-01-20

    Polymer-Electrolyte-Membrane Fuel Cells (PEMFC) are attractive candidates for next century propulsion systems in passenger cars. The technical feasibility has been demonstrated by several car manufacturers. Today, PEMFC lack economical viability. One of the reasons is the cost of currently used materials, e.g. membranes. This project target towards the development of low cost, non-fluorinated membranes, which fulfil all technical requirements in PEMFC systems. In the frame of this project we were able to successfully develop new membranes based on polyaromatic polymers, which can be produced on a technical scale. These membranes enabled high power densities, exceeding 700 mW/cm{sup 2} at 80 C and their longevity has been demonstrated successfully up to 5,000 hours. Therefore, these membranes have sufficient electrochemical stability for the application in fuel cells. The prices in mass production for these new membranes can get significantly below prices of fluorinated membranes. (orig.) [Deutsch] Polymer-Elektrolyt-Membran-Brennstoffzellen (PEMFC) gelten als aussichtsreiche Kandidaten fuer alternative Fahrzeugantriebe fuer das naechste Jahrzehnt. Die technische Machbarkeit ist bereits mehrfach demonstriert worden. Allerdings sind die Kosten der PEMFC-Systeme noch zu hoch u.a. durch zu hohe Kosten der eingesetzten Materialien, so auch der Membranen. Ziel des Projektes war daher die Entwicklung kostenguenstiger, nichtfluorierter Membranen, die die technischen Anforderungen fuer die Anwendung in der PEM-Brennstoffzelle erfuellen. Im Projekt konnten erfolgreich Membranen auf Basis polyaromatischer Polymere entwickelt werden, die sich auch im technischen Massstab herstellen lassen. Die Membranen ermoeglichen hohe Leistungsdichten groesser 700 mW/cm{sup 2} bei Betriebstemperaturen von 80 C. Die Lebensdauer der Membranen wurde erfolgreich ueber 5.000 Stunden nachgewiesen. Die elektrochemische Stabilitaet der untersuchten Materialien ist damit gegeben. Die Preise dieser

  17. Evaluation of robustness of fly ash stabilized sewage sludge (FSS) as liner - Durability, percolation and drainage water quality; Bedoemning av laangtidsegenskaper hos taetskikt bestaaende av flygaskastabiliserat avloppsslam, FSA - Bestaendighet, taethet och ytutlakning

    Energy Technology Data Exchange (ETDEWEB)

    Macsik, Josef; Laendell, Maerta; Haakansson, Karsten

    2012-02-15

    This project shows that fly ash stabilized sewage sludge (FSS) is watertight and resistant as liner in landfills. The presented results can lead to that more landfills will use FSS as liner, and landfills already using FSS together with geomembrane, can leave out the latter without risking contamination of the drainage water collected by the closure construction

  18. Comorbidity, Pain, Utilization, and Psychosocial Outcomes in Older versus Younger Sickle Cell Adults: The PiSCES Project

    Directory of Open Access Journals (Sweden)

    Donna K. McClish

    2017-01-01

    Full Text Available Background. Patients with SCD now usually live well into adulthood. Whereas transitions into adulthood are now often studied, little is published about aging beyond the transition period. We therefore studied age-associated SCD differences in utilization, pain, and psychosocial variables. Methods. Subjects were 232 adults in the Pain in Sickle Cell Epidemiology Study (PiSCES. Data included demographics, comorbidity, and psychosocial measures. SCD-related pain and health care utilization were recorded in diaries. We compared 3 age groups: 16–25 (transition, 26–36 (younger adults, and 37–64 (older adults years. Results. Compared to the 2 adult groups, the transition group reported fewer physical challenges via comorbidities, somatic complaints, and pain frequency, though pain intensity did not differ on crisis or noncrisis pain days. The transition group utilized opioids less often, made fewer ambulatory visits, and had better quality of life, but these differences disappeared after adjusting for pain and comorbidities. However, the transition group reported more use of behavioral coping strategies. Conclusion. We found fewer biological challenges, visits, and better quality of life, in transition-aged versus older adults with SCD, but more behavioral coping. Further study is required to determine whether age-appropriate health care, behavioral, or other interventions could improve age-specific life challenges of patients with SCD.

  19. Blood Outgrowth Endothelial Cells Increase Tumor Growth Rates and Modify Tumor Physiology: Relevance for Therapeutic Targeting

    Energy Technology Data Exchange (ETDEWEB)

    Pagan, Jonathan, E-mail: jdpagan@uams.edu; Przybyla, Beata; Jamshidi-Parsian, Azemat [Department of Radiation Oncology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205 (United States); Gupta, Kalpna [Vascular Biology Center and Division of Hematology-Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, MN 72223 (United States); Griffin, Robert J. [Department of Radiation Oncology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205 (United States)

    2013-02-18

    Endothelial cell precursors from human peripheral blood have been shown to home to areas of neovascularization and may assist tumor growth by increasing or fortifying blood vessel growth. In the present study, the influence of these cells on tumor growth and physiology was investigated and the role of these cells as a therapeutic target or in determining treatment sensitivity was tested. After isolation from human blood and expansion in vitro, actively growing cells with verified endothelial phenotype (Blood Outgrowth Endothelial Cell, BOEC) were injected i.v. into tumor bearing mice for three consecutive days. The growth rate was significantly enhanced in relatively small RERF human lung tumors (i.e., less than 150 mm{sup 3}) grown in immunocompromised mice by an average of 1.5-fold while it had no effect when injections were given to animals bearing larger tumors. There were no signs of toxicity or unwanted systemic effects. We also observed evidence of increased perfusion, vessel number, response to 15 Gy radiation and oxygenation in RERF tumors of animals injected with BOECs compared to control tumors. In addition, FSaII murine fibrosarcoma tumors were found to grow faster upon injection of BOECs. When FSaII tumors were subjected to a partial thermal ablation treatment using high intensity focused ultrasound (HIFU) there was consistently elevated detection of fluorescently labeled and i.v. injected endothelial precursors in the tumor when analyzed with optical imaging and/or histological preparations. Importantly, we also observed that BOECs treated with the novel anti-angiogenic peptide anginex in-vitro, show decreased proliferation and increased sensitivity to radiation. In vivo, the normal increase in FSaII tumor growth induced by injected BOECs was blunted by the addition of anginex treatment. It appears that endothelial precursors may significantly contribute to tumor vessel growth, tumor progression and/or repair of tumor damage and may improve the

  20. Blood Outgrowth Endothelial Cells Increase Tumor Growth Rates and Modify Tumor Physiology: Relevance for Therapeutic Targeting

    International Nuclear Information System (INIS)

    Pagan, Jonathan; Przybyla, Beata; Jamshidi-Parsian, Azemat; Gupta, Kalpna; Griffin, Robert J.

    2013-01-01

    Endothelial cell precursors from human peripheral blood have been shown to home to areas of neovascularization and may assist tumor growth by increasing or fortifying blood vessel growth. In the present study, the influence of these cells on tumor growth and physiology was investigated and the role of these cells as a therapeutic target or in determining treatment sensitivity was tested. After isolation from human blood and expansion in vitro, actively growing cells with verified endothelial phenotype (Blood Outgrowth Endothelial Cell, BOEC) were injected i.v. into tumor bearing mice for three consecutive days. The growth rate was significantly enhanced in relatively small RERF human lung tumors (i.e., less than 150 mm 3 ) grown in immunocompromised mice by an average of 1.5-fold while it had no effect when injections were given to animals bearing larger tumors. There were no signs of toxicity or unwanted systemic effects. We also observed evidence of increased perfusion, vessel number, response to 15 Gy radiation and oxygenation in RERF tumors of animals injected with BOECs compared to control tumors. In addition, FSaII murine fibrosarcoma tumors were found to grow faster upon injection of BOECs. When FSaII tumors were subjected to a partial thermal ablation treatment using high intensity focused ultrasound (HIFU) there was consistently elevated detection of fluorescently labeled and i.v. injected endothelial precursors in the tumor when analyzed with optical imaging and/or histological preparations. Importantly, we also observed that BOECs treated with the novel anti-angiogenic peptide anginex in-vitro, show decreased proliferation and increased sensitivity to radiation. In vivo, the normal increase in FSaII tumor growth induced by injected BOECs was blunted by the addition of anginex treatment. It appears that endothelial precursors may significantly contribute to tumor vessel growth, tumor progression and/or repair of tumor damage and may improve the

  1. Does Adipose-derived Stromal Cell Adjuvant Therapy for Fragmented Medial Coronoid Process in Dogs Influence Outcome? A Pilot Project

    Directory of Open Access Journals (Sweden)

    Kristina M Kiefer

    2016-11-01

    Full Text Available Objective: The primary objective of this study was to identify adverse events associated with multiple intra-articular injections of adipose stromal cell (ASC therapy and secondarily to objectively assess the therapeutic effect of ASC therapy for treatment of fragmented medial coronoid process (FMCP in dogs when used as an adjuvant to standard of care (SOC treatment. Background: Preliminary trials assessing autologous ASC therapy to treat osteoarthritis indicate a positive impact on clinical signs, but assessment of donated, allogeneic ASC therapy is lacking.Evidentiary value: This prospective, randomised, controlled trial in dogs (n=30 provides objective evidence for clinical practitioners regarding ASC therapy in a naturally occurring osteoarthritic disease model.Methods: Dogs diagnosed with FMCP and osteoarthritis were enrolled. All dogs had arthroscopic fragment removal and proximal ulnar osteotomy (PUO and were assigned into three groups (n=10/group: 1 control group with no further treatment beyond the PUO and fragment removal (SOC, 2 PUO + autologous ASCs and 3 PUO+ allogeneic ASCs. Each dog had force platform gait analysis, Canine Brief Pain Inventory (CBPI questionnaires, and delayed gadolinium enhanced magnetic resonance imaging scores prior to and six months after therapeutic intervention.Results: No serious adverse events were reported in any participant. 3/10 dogs in the control group, 3/10 autologous ASC group and 7/10 allogeneic ASC group participants were assessed as successful outcomes.Conclusion: This study provides preliminary safety data for the use of intra-articular allogeneic ASC therapy to treat osteoarthritis, and justification for larger clinical studies.Application: Clinical practitioners considering ASC therapy within their practice are provided with additional evidence of autologous ASC therapy for osteoarthritis. Researchers committed to developing and generating effective ASC therapies are provided with safety

  2. Cell viability and PSA secretion assays in LNCaP cells: a tiered in vitro approach to screen chemicals with a prostate-mediated effect on male reproduction within the ReProTect project.

    Science.gov (United States)

    Lorenzetti, Stefano; Marcoccia, Daniele; Narciso, Laura; Mantovani, Alberto

    2010-08-01

    Prostate function is critical for male fertility; nevertheless, prostate was so far overlooked in reproductive toxicity assays. Within the EU project ReProTect, the human prostate cell line LNCaP was utilized to identify molecules targeting prostate function by the integrated assessment of cell viability (MTS assay) and prostate-specific antigen (PSA) secretion as specific marker; a training set - five (anti)androgenic chemicals - and a ReProTect feasibility set - ten chemicals - were used. Several compounds reduced PSA only at cytotoxic concentrations. Androgens (DHT, MT) markedly increased PSA as did the herbicide glufosinate ammonium, not known as androgen agonist. Anti-androgens (2OH-flutamide, linuron, vinclozolin, di-n-butyl phthalate) also increased PSA, but the effect of magnitude was much lower than for androgens. The ER-binder bisphenol A reduced PSA, while increasing cell viability. At this stage, the approach can identify chemicals able to interfere with prostate function: further refinements may allow to include prostate effects in reproductive toxicity in vitro testing. Copyright 2010 Elsevier Inc. All rights reserved.

  3. Define Project

    DEFF Research Database (Denmark)

    Munk-Madsen, Andreas

    2005-01-01

    "Project" is a key concept in IS management. The word is frequently used in textbooks and standards. Yet we seldom find a precise definition of the concept. This paper discusses how to define the concept of a project. The proposed definition covers both heavily formalized projects and informally...... organized, agile projects. Based on the proposed definition popular existing definitions are discussed....

  4. Project Management

    DEFF Research Database (Denmark)

    Project Management Theory Meets Practice contains the proceedings from the 1st Danish Project Management Research Conference (DAPMARC 2015), held in Copenhagen, Denmark, on May 21st, 2015.......Project Management Theory Meets Practice contains the proceedings from the 1st Danish Project Management Research Conference (DAPMARC 2015), held in Copenhagen, Denmark, on May 21st, 2015....

  5. Project Management

    DEFF Research Database (Denmark)

    Pilkington, Alan; Chai, Kah-Hin; Le, Yang

    2015-01-01

    This paper identifies the true coverage of PM theory through a bibliometric analysis of the International Journal of Project Management from 1996-2012. We identify six persistent research themes: project time management, project risk management, programme management, large-scale project management......, project success/failure and practitioner development. These differ from those presented in review and editorial articles in the literature. In addition, topics missing from the PM BOK: knowledge management project-based organization and project portfolio management have become more popular topics...

  6. Project financing

    International Nuclear Information System (INIS)

    Cowan, A.

    1998-01-01

    Project financing was defined ('where a lender to a specific project has recourse only to the cash flow and assets of that project for repayment and security respectively') and its attributes were described. Project financing was said to be particularly well suited to power, pipeline, mining, telecommunications, petro-chemicals, road construction, and oil and gas projects, i.e. large infrastructure projects that are difficult to fund on-balance sheet, where the risk profile of a project does not fit the corporation's risk appetite, or where higher leverage is required. Sources of project financing were identified. The need to analyze and mitigate risks, and being aware that lenders always take a conservative view and gravitate towards the lowest common denominator, were considered the key to success in obtaining project financing funds. TransAlta Corporation's project financing experiences were used to illustrate the potential of this source of financing

  7. Photovoltaic concentrator technology development project. Sixth project integration meeting

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    Thirty-three abstracts and short papers are presented which describe the current status of research, development, and demonstration of concentrator solar cell technology. Solar concentrators discussed include the parabolic trough, linear focus Fresnel lens, point focus Fresnel lens, and the parabolic dish. Solar cells studied include silicon, GaAs, and AlGaAs. Research on multiple junction cells, combined photovoltaic/thermal collectors, back contact solar cells, and beam splitter modules is described. Concentrator solar cell demonstration programs are reported. Contractor status summaries are given for 33 US DOE concentrator solar cell contracts; a description of the project, project status, and key results to date is included. (WHK)

  8. Project descriptions

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    This part specifies the activities and project tasks of each project broken down according to types of financing, listing the current projects Lw 1 through 3 funded by long-term provisions (budget), the current projects LB 1 and 2, LG 1 through 5, LK1, LM1, and LU 1 through 6 financed from special funds, and the planned projects ZG 1 through 4 and ZU 1, also financed from special funds. (DG) [de

  9. Project studies

    DEFF Research Database (Denmark)

    Geraldi, Joana; Söderlund, Jonas

    2018-01-01

    Project organising is a growing field of scholarly inquiry and management practice. In recent years, two important developments have influenced this field: (1) the study and practice of projects have extended their level of analysis from mainly focussing on individual projects to focussing on micro......, and of the explanations of project practices they could offer. To discuss avenues for future research on projects and project practice, this paper suggests the notion of project studies to better grasp the status of our field. We combine these two sets of ideas to analyse the status and future options for advancing...... project research: (1) levels of analysis; and (2) type of research. Analysing recent developments within project studies, we observe the emergence of what we refer to as type 3 research, which reconciles the need for theoretical development and engagement with practice. Type 3 research suggests pragmatic...

  10. Sensitivity of whole-body CT and MRI versus projection radiography in the detection of osteolyses in patients with monoclonal plasma cell disease

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, Maya B., E-mail: m.mueller-wolf@dkfz.de [Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg Germany (Germany); Department of Radiology, German Cancer Research Center (Dkfz), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany); Murray, Fritz, E-mail: fritz.murray@hotmail.de [Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg Germany (Germany); Kilk, Kerstin, E-mail: k_fechtner@hotmail.com [Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg Germany (Germany); Hillengass, Jens, E-mail: jens.hillengass@med.uni-heidelberg.de [Department of Haematology, Oncology, Rheumatology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg (Germany); Delorme, Stefan, E-mail: s.delorme@dkfz-heidelberg.de [Department of Radiology, German Cancer Research Center (Dkfz), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany); Heiss, Christiane, E-mail: c.heiss@dkfz-heidelberg.de [Department of Biostatistics, German Cancer Research Center (Dkfz), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany); Neben, Kai, E-mail: k.neben@klinikum-mittelbaden.de [Department of Haematology, Oncology, Rheumatology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg (Germany); Goldschmidt, Hartmut, E-mail: hartmut.goldschmidt@med.uni-heidelberg.de [Department of Haematology, Oncology, Rheumatology, University Hospital Heidelberg and National Center for Tumour Diseases, Im Neuenheimer Feld 410, 69120 Heidelberg (Germany); Kauczor, Hans-Ulrich, E-mail: hu.kauczor@med.uni-heidelberg.de [Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg Germany (Germany); and others

    2014-07-15

    Purpose: To compare sensitivity of whole-body Computed Tomography (wb-CT) and whole-body Magnetic Resonance Imaging (wb-MRI) with Projection Radiography (PR) regarding each method's ability to detect osteolyses in patients with monoclonal plasma cell disease. Patients and methods: The bone status of 171 patients was evaluated. All patients presented with multiple myeloma (MM) of all stages, monoclonal gammopathy of unknown significance (MGUS) or solitary plasmacytoma. Two groups were formed. Group A consisted of 52 patients (26 females, 26 males) with an average age of 62 years (range, 45–89 years) who received, both, PR and wb-CT as part of their diagnostic work-up. Group B comprised 119 patients (58 females, 61 males) averaging 57 years of age (range, 20–80 years) who received, both, PR and wb-MRI. Two experienced radiologists were blinded regarding the disease status and assessed the number and location of osteolyses in consensus. A distinction was made between axial and extra-axial lesions. Results: In group A, wb-CT revealed osteolyses in 12 patients (23%) that were not detected in PR. CT was superior in detecting lesions in patients with osteopenia and osteoporosis. Compared with PR, wb-CT was significantly more sensitive in detecting osteolyses than PR (p < 0.001). This was particularly true for axial lesions. Additionally, CT revealed clinically relevant incidental findings in 33 patients (63%). In group B, wb-MRI revealed lesions in 19 patients (16%) that were not detected in PR. All lesions detected by PR were also detected by wb-MRI and wb-CT. Wb-MRI and wb-CT are each superior to PR in detecting axial lesions. Conclusion: Wb-CT can detect 23% more focal lesions than PR, especially in the axial skeleton. Therefore, this imaging method should be preferred over PR in the diagnostic work-up and staging of patients with monoclonal plasma cell disease.

  11. Virtual projects

    DEFF Research Database (Denmark)

    Svejvig, Per; Commisso, Trine Hald

    2012-01-01

    that the best practice knowledge has not permeated sufficiently to the practice. Furthermore, the appropriate application of information and communication technology (ICT) remains a big challenge, and finally project managers are not sufficiently trained in organizing and conducting virtual projects....... The overall implications for research and practice are to acknowledge virtual project management as very different to traditional project management and to address this difference.......Virtual projects are common with global competition, market development, and not least the financial crisis forcing organizations to reduce their costs drastically. Organizations therefore have to place high importance on ways to carry out virtual projects and consider appropriate practices...

  12. Project financing

    International Nuclear Information System (INIS)

    Alvarez, M.U.

    1990-01-01

    This paper presents the basic concepts and components of the project financing of large industrial facilities. Diagrams of a simple partnership structure and a simple leveraged lease structure are included. Finally, a Hypothetical Project is described with basic issues identified for discussion purposes. The topics of the paper include non-recourse financing, principal advantages and objectives, disadvantages, project financing participants and agreements, feasibility studies, organization of the project company, principal agreements in a project financing, insurance, and an examination of a hypothetical project

  13. Analysis of power balancing with fuel cells and hydrogen production plants in Denmark. Project report; CanDan 1.5

    Energy Technology Data Exchange (ETDEWEB)

    2009-03-15

    In the past few years electric vehicles and other electric storage devices ability to hybridize the electric grid have gained increasing interest. Electric vehicles and their ability to hybridize the electric grid are especially interesting in a Danish context for two reasons. There is limited storage capacity in the Danish electric grid and it is therefore expensive to hybridize (balance power and energy supply and usage) in the Danish electric grid. An increasing use of fluctuating renewable energy, especially in the form of electricity from wind power, will make it more and more difficult and expensive to hybridise the Danish electricity grid. On top of this electric vehicles are getting closer and closer to the market because of better electric drive trains, better batteries, better fuel cells etc. The purpose of this report is therefore to analyse how future hydrogen production and hydrogen use in stationary fuel cells as well as fuel cells in vehicles can help balance power and energy in a future electric grid with high shares of fluctuating renewable energy. Emphasis is on future hydrogen production using high temperature solid oxide electrolysers and the use of this in 500.000 hydrogen fuel cell vehicles (HFCV) or in 500.000 plug-in hybrid hydrogen fuel cell vehicles (hybrid HFCV). Analysis made by Aalborg University in the project show that vehicles using hydrogen are generally better at using excess electricity, i.e. to integrate fluctuating renewable energy than the battery electric vehicles. Already in 2012 the battery electric vehicles, which have the ability to charge at the right times, as well as hydrogen based vehicles may remove the excess electricity consumption. Although the hydrogen production at electrolysers may be able to remove excess electricity production, the efficiency is rather low. The battery electric vehicles have the lowest fuel consumption, already in the present energy system. The CO{sub 2}-emissions are also the lowest for the

  14. Final report on LDRD project : elucidating performance of proton-exchange-membrane fuel cells via computational modeling with experimental discovery and validation.

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Chao Yang (Pennsylvania State University, University Park, PA); Pasaogullari, Ugur (Pennsylvania State University, University Park, PA); Noble, David R.; Siegel, Nathan P.; Hickner, Michael A.; Chen, Ken Shuang

    2006-11-01

    In this report, we document the accomplishments in our Laboratory Directed Research and Development project in which we employed a technical approach of combining experiments with computational modeling and analyses to elucidate the performance of hydrogen-fed proton exchange membrane fuel cells (PEMFCs). In the first part of this report, we document our focused efforts on understanding water transport in and removal from a hydrogen-fed PEMFC. Using a transparent cell, we directly visualized the evolution and growth of liquid-water droplets at the gas diffusion layer (GDL)/gas flow channel (GFC) interface. We further carried out a detailed experimental study to observe, via direct visualization, the formation, growth, and instability of water droplets at the GDL/GFC interface using a specially-designed apparatus, which simulates the cathode operation of a PEMFC. We developed a simplified model, based on our experimental observation and data, for predicting the onset of water-droplet instability at the GDL/GFC interface. Using a state-of-the-art neutron imaging instrument available at NIST (National Institute of Standard and Technology), we probed liquid-water distribution inside an operating PEMFC under a variety of operating conditions and investigated effects of evaporation due to local heating by waste heat on water removal. Moreover, we developed computational models for analyzing the effects of micro-porous layer on net water transport across the membrane and GDL anisotropy on the temperature and water distributions in the cathode of a PEMFC. We further developed a two-phase model based on the multiphase mixture formulation for predicting the liquid saturation, pressure drop, and flow maldistribution across the PEMFC cathode channels. In the second part of this report, we document our efforts on modeling the electrochemical performance of PEMFCs. We developed a constitutive model for predicting proton conductivity in polymer electrolyte membranes and compared

  15. Microsoft project

    OpenAIRE

    Markić, Lucija; Mandušić, Dubravka; Grbavac, Vitomir

    2005-01-01

    Microsoft Project je alat čije su prednosti u svakodnevnom radu nezamjenjive. Pomoću Microsoft Projecta omogućeno je upravljanje resursima, stvaranje izvještaja o projektima u vremenu, te analize različitih scenarija. Pojavljuje u tri verzije: Microsoft Project Professional, Microsoft Project Server i Microsoft Project Server Client Access Licenses. Upravo je trend da suvremeni poslovni ljudi zadatke povjeravaju Microsoft Projectu jer on znatno povećava produktivnost rada. Te prednos...

  16. Project ethics

    CERN Document Server

    Jonasson, Haukur Ingi

    2013-01-01

    How relevant is ethics to project management? The book - which aims to demystify the field of ethics for project managers and managers in general - takes both a critical and a practical look at project management in terms of success criteria, and ethical opportunities and risks. The goal is to help the reader to use ethical theory to further identify opportunities and risks within their projects and thereby to advance more directly along the path of mature and sustainable managerial practice.

  17. The Methanol Economy Project

    Energy Technology Data Exchange (ETDEWEB)

    Olah, George [Univ. of Southern California, Los Angeles, CA (United States); Prakash, G. K. [Univ. of Southern California, Los Angeles, CA (United States)

    2014-02-01

    The Methanol Economy Project is based on the concept of replacing fossil fuels with methanol generated either from renewable resources or abundant natural (shale) gas. The full methanol cycle was investigated in this project, from production of methanol through bromination of methane, bireforming of methane to syngas, CO2 capture using supported amines, co-electrolysis of CO2 and water to formate and syngas, decomposition of formate to CO2 and H2, and use of formic acid in a direct formic acid fuel cell. Each of these projects achieved milestones and provided new insights into their respective fields.

  18. Energy Storage Project

    Science.gov (United States)

    Mercer, Carolyn R.; Jankovsky, Amy L.; Reid, Concha M.; Miller, Thomas B.; Hoberecht, Mark A.

    2011-01-01

    NASA's Exploration Technology Development Program funded the Energy Storage Project to develop battery and fuel cell technology to meet the expected energy storage needs of the Constellation Program for human exploration. Technology needs were determined by architecture studies and risk assessments conducted by the Constellation Program, focused on a mission for a long-duration lunar outpost. Critical energy storage needs were identified as batteries for EVA suits, surface mobility systems, and a lander ascent stage; fuel cells for the lander and mobility systems; and a regenerative fuel cell for surface power. To address these needs, the Energy Storage Project developed advanced lithium-ion battery technology, targeting cell-level safety and very high specific energy and energy density. Key accomplishments include the development of silicon composite anodes, lithiated-mixed-metal-oxide cathodes, low-flammability electrolytes, and cell-incorporated safety devices that promise to substantially improve battery performance while providing a high level of safety. The project also developed "non-flow-through" proton-exchange-membrane fuel cell stacks. The primary advantage of this technology set is the reduction of ancillary parts in the balance-of-plant--fewer pumps, separators and related components should result in fewer failure modes and hence a higher probability of achieving very reliable operation, and reduced parasitic power losses enable smaller reactant tanks and therefore systems with lower mass and volume. Key accomplishments include the fabrication and testing of several robust, small-scale nonflow-through fuel cell stacks that have demonstrated proof-of-concept. This report summarizes the project s goals, objectives, technical accomplishments, and risk assessments. A bibliography spanning the life of the project is also included.

  19. Project Temporalities

    DEFF Research Database (Denmark)

    Tryggestad, Kjell; Justesen, Lise; Mouritsen, Jan

    2013-01-01

    Purpose – The purpose of this paper is to explore how animals can become stakeholders in interaction with project management technologies and what happens with project temporalities when new and surprising stakeholders become part of a project and a recognized matter of concern to be taken...... into account. Design/methodology/approach – The paper is based on a qualitative case study of a project in the building industry. The authors use actor-network theory (ANT) to analyze the emergence of animal stakeholders, stakes and temporalities. Findings – The study shows how project temporalities can...... multiply in interaction with project management technologies and how conventional linear conceptions of project time may be contested with the emergence of new non-human stakeholders and temporalities. Research limitations/implications – The study draws on ANT to show how animals can become stakeholders...

  20. Development and test of 2 kW natural gas reformers for high and low temperature PEM fuel cells. Project report 2; Udvikling/afproevning af 2 kW naturgasreformere for hoej- og lavtemperatur PEM-braendselsceller. Projektrapport 2

    Energy Technology Data Exchange (ETDEWEB)

    Wit, J. de [Dansk Gasteknisk Center (Denmark); Bech-Madsen, J. [IRD (Denmark); Bandur, V. [DTU (Denmark); Bartholin, N. [DPS (Denmark)

    2005-11-15

    The use of fuel cells for combined heat and power generation has advantages as regards technology and usability compared to existing CHP technology. Special characteristics for a fuel cell plant are: 1) It can be constructed in modules over a wide power range, 2) The efficiency is significantly independent of size, 3) It is noiseless, 4) A flexible coupling between power and heat production, 5) As there is no movable parts, long service check intervals can be expected, 6) Low emissions. The fuel for fuel cells is hydrogen and optimal utilization and CO{sub 2} reduction will require a 'hydrogen society'. While waiting for a 'hydrogen society' to arise, it is possible to use central or on-site reformers that convert natural gas to hydrogen. There will be some CO{sub 2} emission connected to energy use. The objective of the present project has been development and test of on-site reformers (fuel processors) for hydrogen supply to respectively high and low temperature PEM fuel cells aiming at use in single family houses. Sulphur cleaning, reformers, and lab-scale coupling with fuel cell KV units have been developed and tested during the project, as well as development and test of periphery equipment. (BA)

  1. LEX Project

    DEFF Research Database (Denmark)

    Damkilde, Lars; Larsen, Torben J.; Walbjørn, Jacob

    This document is aimed at helping all parties involved in the LEX project to get a common understanding of words, process, levels and the overall concept.......This document is aimed at helping all parties involved in the LEX project to get a common understanding of words, process, levels and the overall concept....

  2. OMEGA project

    International Nuclear Information System (INIS)

    Shibuya, E.H.

    1989-01-01

    The OMEGA - Observation of Multiple particle production, Exotic Interactions and Gamma-ray Air Shower-project is presented. The project try to associate photosensitive detectors from experiences of hadronic interactions with electronic detectors used by experiences that investigate extensive atmospheric showers. (M.C.K.)

  3. Watchdog Project

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Rhett [Schweitzer Engineering Laboratories, Inc., Pullman, WA (United States); Campbell, Jack [CenterPoint Energy Houston Electric, TX (United States); Hadley, Mark [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-12-30

    The Watchdog Project completed 100% of the project Statement of Project Objective (SOPO). The Watchdog project was a very aggressive project looking to accomplish commercialization of technology that had never been commercialized, as a result it took six years to complete not the original three that were planned. No additional federal funds were requested from the original proposal and SEL contributed the additional cost share required to complete the project. The result of the Watchdog Project is the world’s first industrial rated Software Defined Network (SDN) switch commercially available. This technology achieved the SOPOO and DOE Roadmap goals to have strong network access control, improve reliability and network performance, and give the asset owner the ability to minimize attack surface before and during an attack. The Watchdog project is an alliance between CenterPoint Energy Houston Electric, Pacific Northwest National Laboratories (PNNL), and Schweitzer Engineering Laboratories, Inc. (SEL). SEL is the world’s leader in microprocessor-based electronic equipment for protecting electric power systems. PNNL performs basic and applied research to deliver energy, environmental, and national security for our nation. CenterPoint Energy is the third largest publicly traded natural gas delivery company in the U.S and third largest combined electricity and natural gas delivery company. The Watchdog Project efforts were combined with the SDN Project efforts to produce the entire SDN system solution for the critical infrastructure. The Watchdog project addresses Topic Area of Interest 5: Secure Communications, for the DEFOA- 0000359 by protecting the control system local area network itself and the communications coming from and going to the electronic devices on the local network. Local area networks usually are not routed and have little or no filtering capabilities. Combine this with the fact control system protocols are designed with inherent trust the control

  4. Freedom Project

    Directory of Open Access Journals (Sweden)

    Alejandra Suarez

    2014-02-01

    Full Text Available Freedom Project trains prisoners in nonviolent communication and meditation. Two complementary studies of its effects are reported in this article. The first study is correlational; we found decreased recidivism rates among prisoners trained by Freedom Project compared with recidivism rates in Washington state. The second study compared trained prisoners with a matched-pair control group and found improvement in self-reported anger, self-compassion, and certain forms of mindfulness among the trained group. Ratings of role-plays simulating difficult interactions show increased social skills among the group trained by Freedom Project than in the matched controls.

  5. HSAPS market analysis project

    Energy Technology Data Exchange (ETDEWEB)

    Gloeckner, Ronny; Aaberg, Rolf Jarle

    2006-12-15

    The H-SAPS (Hydrogen Stand-Alone Power System) project, an EU project within the ALTENER programme in the period 2002-2004, was initiated to determine the potential for the introduction of environmentally benign hydrogen technology in what is believed to be a near-term market, namely stand-alone power systems (SAPS). The objective of the project was to examine the technological, political, social and economical factors affecting the emergence of hydrogen technology in the stand-alone power system market today and in the future. The scope of the project was limited to small and medium sized stand-alone power systems, up to a few hundred kilowatts (kW) power rating and based on renewable energy as the primary energy source. The work was divided into five phases: (1) Inception, (2) Data collection and analysis, (3) Market analysis and barrier removal, (4) Dissemination, and (5) Final report. Separate reports were written on these topics, and later summarised this final report. The H-SAPS-project identified the following critical technical barriers (in prioritized order): (1) High costs of both electrolyser and fuel cell solutions, (2) Short lifetime warranties and little lifetime experience for PEM electrolysers and PEM fuel cells, (3) Low energy efficiency of the hydrogen energy system (critical for small systems), and (4) The need to develop easy-to-use and energy efficient gas and electricity control systems. One of the main conclusions from the project is that there is a need to focus on interim solutions, based on conventional energy technologies (e.g., internal combustion engines instead of fuel cells), in order for H-SAPS to compete in the near-term SAPS-market (author) (ml)

  6. HSAPS market analysis project

    International Nuclear Information System (INIS)

    Gloeckner, Ronny; Aaberg, Rolf Jarle

    2006-12-01

    The H-SAPS (Hydrogen Stand-Alone Power System) project, an EU project within the ALTENER programme in the period 2002-2004, was initiated to determine the potential for the introduction of environmentally benign hydrogen technology in what is believed to be a near-term market, namely stand-alone power systems (SAPS). The objective of the project was to examine the technological, political, social and economical factors affecting the emergence of hydrogen technology in the stand-alone power system market today and in the future. The scope of the project was limited to small and medium sized stand-alone power systems, up to a few hundred kilowatts (kW) power rating and based on renewable energy as the primary energy source. The work was divided into five phases: (1) Inception, (2) Data collection and analysis, (3) Market analysis and barrier removal, (4) Dissemination, and (5) Final report. Separate reports were written on these topics, and later summarised this final report. The H-SAPS-project identified the following critical technical barriers (in prioritized order): (1) High costs of both electrolyser and fuel cell solutions, (2) Short lifetime warranties and little lifetime experience for PEM electrolysers and PEM fuel cells, (3) Low energy efficiency of the hydrogen energy system (critical for small systems), and (4) The need to develop easy-to-use and energy efficient gas and electricity control systems. One of the main conclusions from the project is that there is a need to focus on interim solutions, based on conventional energy technologies (e.g., internal combustion engines instead of fuel cells), in order for H-SAPS to compete in the near-term SAPS-market (author) (ml)

  7. EBFA project

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    An engineering project office was established during the fall of 1976 to manage and coordinate all of the activities of the Electron Beam Fusion Project. The goal of the project is to develop the Electron Beam Fusion Accelerator (EBFA) and its supporting systems, and integrate these systems into the new Electron Beam Fusion Facility (EBFF). Supporting systems for EBFA include a control/monitor system, a data acquistion/automatic data processing system, the liquid transfer systems, the insulating gas transfer systems, etc. Engineers and technicians were assigned to the project office to carry out the engineering design, initiate procurement, monitor the fabrication, perform the assembly and to assist the pulsed power research group in the activation of the EBFA

  8. Project Reptile!

    Science.gov (United States)

    Diffily, Deborah

    2001-01-01

    Integrating curriculum is important in helping children make connections within and among areas. Presents a class project for kindergarten children which came out of the students' interests and desire to build a reptile exhibit. (ASK)

  9. Project Soar.

    Science.gov (United States)

    Austin, Marion

    1982-01-01

    Project Soar, a Saturday enrichment program for gifted students (6-14 years old), allows students to work intensively in a single area of interest. Examples are cited of students' work in crewel embroidery, creative writing, and biochemistry. (CL)

  10. EUROFANCOLEN Project

    International Nuclear Information System (INIS)

    Bueren, J. A.

    2014-01-01

    The first follow-up report of European Project EUROFANCOLEN, the purpose of which is to develop a gene therapy clinical trial to resolve bone marrow failure in patients with a genetic disease known as Fanconi anemia (FA), was sent to the European Commission in September. The main objective of project EUROFANCOLEN is to develop a gene therapy trial for patients with Fanconi anemia Type A (FA-A), which affects 80% of the patients with FA in Spain. (Author)

  11. Project Management

    DEFF Research Database (Denmark)

    Kampf, Constance

    2009-01-01

    In this video Associate Professor Constance Kampf talks about the importance project management. Not only as a tool in implementation, but also as a way of thinking, and as something that needs to be considered from idea conception......In this video Associate Professor Constance Kampf talks about the importance project management. Not only as a tool in implementation, but also as a way of thinking, and as something that needs to be considered from idea conception...

  12. Pilot project of a small 300 W fuel-cell-powered electrical boat; Projet pilote d'une petite embarcation mue par pile a combustible de 300 W

    Energy Technology Data Exchange (ETDEWEB)

    Affolter, J.-F.

    2000-07-01

    The important demand at the European level for electrical boats shows the great interest for such a technology. We can expect an important growth of electric boats production. Thus, two means could be used to provide a maximum of comfort, reliability, silence, absence of pollution and respect of the environment: photovoltaics and fuel cells. The purpose of the present project is to explore the second solution. A small boat 'Hydroxy100' has been designed as first prototype in the field of a diploma work. A larger boat, 'Hydroxy300', with the use of a 300-watt PEFC fuel cell was realised and successfully presented at the international fuel cells meeting in Lucerne (June 99) and other occasions. The subject is also an excellent didactical application for the electrical degree students of our technical university. (author)

  13. Project mobilisation

    International Nuclear Information System (INIS)

    Clark, J.; Limbrick, A.

    1996-01-01

    This paper identifies and reviews the issues to be addressed and the procedures to be followed during the mobilisation of projects using LFG as an energy source. Knowledge of the procedures involved in project mobilisation, their sequence and probable timescales, is essential for efficient project management. It is assumed that the majority of projects will be situated on existing, licensed landfill sites and, in addition to complying with the relevant conditions of the waste management licence and original planning consent, any proposed developments on the site will require a separate planning consent. Experience in the UK indicates that obtaining planning permission rarely constitutes a barrier to the development of schemes for the utilisation of LFG. Even so, an appreciation of the applicable environmental and planning legislation is essential as this will enable the developer to recognise the main concerns of the relevant planning authority at an early stage of the project, resulting in the preparation of an informed and well-structured application for planning permission. For a LFG utilisation scheme on an existing landfill site, the need to carry out an environmental assessment (EA) as part of the application for planning permission will, in vitually all cases, be discretionary. Even if not deemed necessary by the planning authority, an EA is a useful tool at the planning application stage, to identify and address potential problems and to support discussions with bodies such as the Environment Agency, from whom consents or authorisations may be required. Carrying out an EA can thus provide for more cost-effective project development and enhanced environmental protection. Typically, the principal contractual arrangements, such as the purchase of gas or the sale of electricity, will have been established before the project mobilisation phase. However, there are many other contractural arrangements that must be established, and consents and permits that may be

  14. Validity of the People Risk Framework: Evidence from the FSA

    OpenAIRE

    Chrysostomou, Xenia

    2013-01-01

    The recent Global Financial Crisis was the ultimate manifestation for the recognition and appreciation of people risk, one of the dimensions constituting operational risk, highlighting the necessity of people risk management within the financial industry. In recognition of the magnitude of its impact, ‘people risk’ became a ’hot’ topic amongst the financial regulators, which resulted in the stipulation of assigning capital reserves, exclusively dedicated to its coverage. However, the nature o...

  15. FSA of the Navigational Safety in Baltic West

    DEFF Research Database (Denmark)

    Friis-Hansen, Peter; Ravn, Erik Sonne; Hartmann, J.P.

    2004-01-01

    This paper is the result of a pilot study carried out in the spring of 2004 by the Technical University of Denmark, The Royal Danish Administration of Navigation and Hydrography's and the Danish Maritime Authority. The objective of the pilot study was to illustrate a procedure that allowed a risk...

  16. 33 CFR 106.305 - Facility Security Assessment (FSA) requirements.

    Science.gov (United States)

    2010-07-01

    ... available to maintain essential services; (vi) The essential maintenance equipment and storage areas; (vii... procedures relating to essential services; (v) Measures to protect radio and telecommunication equipment... property, or economic disruption, of an attack on or at the OCS facility; and (7) Locations where access...

  17. 7 CFR 1955.107 - Sale of FSA property (CONACT).

    Science.gov (United States)

    2010-01-01

    ... BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE..., the advertisement should be conditional on that possibility. Real property will be managed in... expires or is terminated. There will be a preference for beginning farmers or ranchers. The advertisement...

  18. Overview of the Facility Safeguardability Analysis (FSA) Process

    Energy Technology Data Exchange (ETDEWEB)

    Bari, Robert A.; Hockert, John; Wonder, Edward F.; Johnson, Scott J.; Wigeland, Roald; Zentner, Michael D.

    2012-08-01

    Executive Summary The safeguards system of the International Atomic Energy Agency (IAEA) is intended to provide the international community with credible assurance that a State is fulfilling its safeguards obligations. Effective and cost-efficient IAEA safeguards at the facility level are, and will remain, an important element of IAEA safeguards as those safeguards evolve towards a “State-Level approach.” The Safeguards by Design (SBD) concept can facilitate the implementation of these effective and cost-efficient facility-level safeguards (Bjornard, et al. 2009a, 2009b; IAEA, 1998; Wonder & Hockert, 2011). This report, sponsored by the National Nuclear Security Administration’s Office of Nuclear Safeguards and Security, introduces a methodology intended to ensure that the diverse approaches to Safeguards by Design can be effectively integrated and consistently used to cost effectively enhance the application of international safeguards.

  19. USDA/FSA Imagery Programs - Public Map Gallery

    Data.gov (United States)

    Farm Service Agency, Department of Agriculture — Imagery programs are an important part of maintaining, creating and updating geospatial data at the USDA Farm Service Agency. Imagery acquisition is provided by the...

  20. 7 CFR 1280.630 - FSA State office report.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... for a period of not less than 12 months after the results have been released and available for public inspection after the results have been released. ...

  1. 7 CFR 1220.627 - FSA State office report.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... summary shall be filed for a period of not less than 12 months after the results have been released and available for public inspection after the results have been released. ...

  2. Farm Services Administration (FSA) Color Orthophotos 2003-2004

    Data.gov (United States)

    Minnesota Department of Natural Resources — This 1 meter resolution, natural color imagery is derived directly from the original uncompressed TIFF quarter-quad orthophotos as provided by LMIC. The Minnesota...

  3. Projective mapping

    DEFF Research Database (Denmark)

    Dehlholm, Christian; Brockhoff, Per B.; Bredie, Wender Laurentius Petrus

    2012-01-01

    by the practical testing environment. As a result of the changes, a reasonable assumption would be to question the consequences caused by the variations in method procedures. Here, the aim is to highlight the proven or hypothetic consequences of variations of Projective Mapping. Presented variations will include...... instructions and influence heavily the product placements and the descriptive vocabulary (Dehlholm et.al., 2012b). The type of assessors performing the method influences results with an extra aspect in Projective Mapping compared to more analytical tests, as the given spontaneous perceptions are much dependent......Projective Mapping (Risvik et.al., 1994) and its Napping (Pagès, 2003) variations have become increasingly popular in the sensory field for rapid collection of spontaneous product perceptions. It has been applied in variations which sometimes are caused by the purpose of the analysis and sometimes...

  4. Isotopes Project

    International Nuclear Information System (INIS)

    Dairiki, J.M.; Browne, E.; Firestone, R.B.; Lederer, C.M.; Shirley, V.S.

    1984-01-01

    The Isotopes Project compiles and evaluates nuclear structure and decay data and disseminates these data to the scientific community. From 1940-1978 the Project had as its main objective the production of the Table of Isotopes. Since publication of the seventh (and last) edition in 1978, the group now coordinates its nuclear data evaluation efforts with those of other data centers via national and international nuclear data networks. The group is currently responsible for the evaluation of mass chains A = 167-194. All evaluated data are entered into the International Evaluated Nuclear Structure Data File (ENSDF) and are published in Nuclear Data Sheets. In addition to the evaluation effort, the Isotopes Project is responsible for production of the Radioactivity Handbook

  5. LLAMA Project

    Science.gov (United States)

    Arnal, E. M.; Abraham, Z.; Giménez de Castro, G.; de Gouveia dal Pino, E. M.; Larrarte, J. J.; Lepine, J.; Morras, R.; Viramonte, J.

    2014-10-01

    The project LLAMA, acronym of Long Latin American Millimetre Array is very briefly described in this paper. This project is a joint scientific and technological undertaking of Argentina and Brazil on the basis of an equal investment share, whose mail goal is both to install and to operate an observing facility capable of exploring the Universe at millimetre and sub/millimetre wavelengths. This facility will be erected in the argentinean province of Salta, in a site located at 4830m above sea level.

  6. 125I-[Tyr0,D-Trp8]somatostatin-14 binding sites in the locus coeruleus of the rat are located on both ascending and descending projecting noradrenergic cells

    International Nuclear Information System (INIS)

    Epelbaum, J.; Bluet-Pajot, M.T.; Llorens-Cortes, C.; Kordon, C.; Mounier, F.; Senut, M.C.; Videau, C.

    1990-01-01

    Radioautographic determinations of 125I-[Tyr0,D-Trp8]somatostatin-14 (125I-SRIF) binding sites were performed on frozen serial sections of the locus coeruleus (LC) of control rats and of rats subjected to either bilateral microinjections of 6 hydroxydopamine (6-OHDA) into the LC or unilateral microinjection into the ascending noradrenergic bundles. These experiments were performed in order to determine whether 125I-SRIF binding was localized to noradrenergic-containing cells and in which regions the cells which contain the binding sites are projecting. The extent of the lesions was assessed by measuring norepinephrine (NE) levels in the hippocampus (88% decrease as compared to sham-operated animals) for bilateral LC lesions and in the frontal cortex (87% reduction vs. contralateral side) for unilateral bundle lesions. In control rats, 125I-SRIF binding sites were restricted to the boundaries of the LC and followed closely the distribution of tyrosine hydroxylase-labeled cells. Three weeks after bilateral injections of 6-OHDA, 125I-SRIF binding decreased by 79% in all regions of the LC. In contrast, unilateral destruction of the ascending noradrenergic bundles resulted in a moderate decrease only in the middle part of the LC with a more important effect in the dorsal (55%) than in the ventral (24%) portion of the nucleus. These data demonstrate that: (1) most SRIF receptors in the LC are located in the vicinity of NE-containing cell bodies and (2) NE-containing cells bearing SRIF receptors project to the forebrain as well as to other terminal areas located more caudally in the brain. These data suggest a general role for SRIF in the control of the multiple functions of the LC

  7. FY 1993 report on the results of the commissioned research and development project. R and D of SOFC (solid oxide fuel cells); 1983 nendo nenryo denchi hatsuden gijutsu kaihatsu seika hokokusho. SOFC kotai denkaishitsugata nenryo denchi no kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-05-01

    The research and development project is carried out for fuel cell power generation technologies and solid electrolyte type fuel cells, and the reports on the FY 1993 results issued by the participant organizations are summarized. For R and D of the modules, Fuji Electric conducted the R and D for the large-area, cell-stacked type, and Sanyo Electric for the composite cell-stacked type. For R and D of the materials and fundamental technologies, Fine Ceramics Center conducted the R and D for microscopic structures of the electrode, Fujikura for electrode structures produced by spraying or the like, Mitsubishi Heavy Industries for multi-functional fuel electrodes, Murata Seisakusho for co-sintering technologies, and Mitsui Shipbuilding for current collecting technologies. For R and D of the systems, Central Research Institute of Electric Power Industry conducted the R and D for the systems, Electric Power Development and Mitsubishi Heavy Industries jointly for designs of the cell peripheries, and the Japan Research and Development Center for Metals for elementary technologies for the peripheral devices. (NEDO)

  8. FY 1992 report on the results of the commissioned research and development project. R and D of SOFC (solid oxide fuel cells); 1992 nendo nenryo denchi hatsuden gijutsu kaihatsu seika hokokusho. SOFC kotai denkaishitsugata nenryo denchi no kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1983-05-01

    The research and development project is carried out for fuel cell power generation technologies and solid electrolyte type fuel cells, and the reports on the FY 1992 results issued by the participant organizations are summarized. For R and D of the modules, Fuji Electric conducted the R and D for the large-area, cell-stacked type, and Sanyo Electric for the composite cell-stacked type. For R and D of the materials and fundamental technologies, Fine Ceramics Center is conducted the R and D for microscopic structures of the electrode, Fujikura for electrode structures produced by spraying or the like, Mitsubishi Heavy Industries for multi-functional fuel electrodes, Murata Seisakusho for co-sintering technologies, and Mitsui Shipbuilding for current collecting technologies. For R and D of the systems, Central Research Institute of Electric Power Industry conducted the R and D for the systems, Electric Power Development and Mitsubishi Heavy Industries jointly for designs of the cell peripheries, and the Japan Research and Development Center for Metals for elementary technologies for the peripheral devices. (NEDO)

  9. Project Avatar

    DEFF Research Database (Denmark)

    Juhlin, Jonas Alastair

    'Project Avatar' tager udgangspunkt i den efterretningsdisciplin, der kaldes Open Source Intelligence og indebærer al den information, som ligger frit tilgængeligt i åbne kilder. Med udbredelsen af sociale medier åbners der op for helt nye typer af informationskilder. Spørgsmålet er; hvor nyttig er...

  10. Project Baltia

    Index Scriptorium Estoniae

    2007-01-01

    Uus arhitektuuriajakiri "Project Baltia" tutvustab Baltimaade, Soome ja Peterburi regiooni arhitektuuri, linnaehitust ja disaini. Ilmub neli korda aastas inglise- ja venekeelsena. Väljaandja: kirjastus Balticum Peterburis koostöös Amsterdami ja Moskva kirjastusega A-Fond. Peatoimetaja Vladimir Frolov

  11. Tedese Project

    Science.gov (United States)

    Buforn, E.; Davila, J. Martin; Bock, G.; Pazos, A.; Udias, A.; Hanka, W.

    The TEDESE (Terremotos y Deformacion Cortical en el Sur de España) project is a joint project of the Universidad Complutense de Madrid (UCM) and Real Instituto y Observatorio de la Armada de San Fernando, Cadiz (ROA) supported by the Spanish Ministerio de Ciencia y Tecnologia with the participation of the GeoforschungZen- trum, Potsdam (GFZ). The aim is to carry out a study of the characteristics of the oc- currence and mechanism of earthquakes together with measurements of crustal struc- ture and deformations in order to obtain an integrated evaluation of seismic risk in southern Spain from. As part of this project a temporal network of 10 broad-band seismological stations, which will complete those already existing in the zone, have been installed in southern Spain and northern Africa for one year beginning in October 2001. The objectives of the project are the study in detail of the focal mechanisms of earthquakes in this area, of structural in crust and upper mantle, of seismic anisotropy in crust and mantle as indicator for tectonic deformation processed and the measure- ments of crustal deformations using techniques with permanent GPS and SLR stations and temporary GPS surveys. From these studies, seismotectonic models and maps will be elaborated and seismic risk in the zone will be evaluated.

  12. Project Boomerang

    Science.gov (United States)

    King, Allen L.

    1975-01-01

    Describes an experimental project on boomerangs designed for an undergraduate course in classical mechanics. The students designed and made their own boomerangs, devised their own procedures, and carried out suitable measurements. Presents some of their data and a simple analysis for the two-bladed boomerang. (Author/MLH)

  13. Project Narrative

    Energy Technology Data Exchange (ETDEWEB)

    Driscoll, Mary C. [St. Bonaventure University, St Bonaventure, NY(United States)

    2012-07-12

    The Project Narrative describes how the funds from the DOE grant were used to purchase equipment for the biology, chemistry, physics and mathematics departments. The Narrative also describes how the equipment is being used. There is also a list of the positive outcomes as a result of having the equipment that was purchased with the DOE grant.

  14. Radiochemistry Project

    International Nuclear Information System (INIS)

    Anon.

    Researches carried out in the 'Radiochemistry Project' of the Agricultural Nuclear Energy Center, Piracicaba, Sao Paulo State, Brazil, are described. Such researches comprise: dosimetry and radiological protection; development of techniques and methods of chemical analysis and radiochemistry. (M.A.) [pt

  15. FLOAT Project

    DEFF Research Database (Denmark)

    Sørensen, Eigil V.; Aarup, Bendt

    The objective of the FLOAT project is to study the reliability of high-performance fibre-reinforced concrete, also known as Compact Reinforced Composite (CRC), for the floats of wave energy converters. In order to reach a commercial breakthrough, wave energy converters need to achieve a lower price...

  16. Hydrology Project

    International Nuclear Information System (INIS)

    Anon.

    Research carried out in the 'Hydrology Project' of the Centro de Energia Nuclear na Agricultura', Piracicaba, Sao Paulo State, Brazil, are described. Such research comprises: Amazon hydrology and Northeast hydrology. Techniques for the measurement of isotope ratios are used. (M.A.) [pt

  17. CHEMVAL project

    International Nuclear Information System (INIS)

    Chandratillake, M.; Falck, W.E.; Read, D.

    1992-01-01

    This report summarises the development history of the CHEMVAL Thermodynamic Database, the criteria employed for data selection and the contents of Version 4.0, issued to participants on the completion of the project. It accompanies a listing of the database constructed using the dBase III + /IV database management package. (Author)

  18. Project COLD.

    Science.gov (United States)

    Kazanjian, Wendy C.

    1982-01-01

    Describes Project COLD (Climate, Ocean, Land, Discovery) a scientific study of the Polar Regions, a collection of 35 modules used within the framework of existing subjects: oceanography, biology, geology, meterology, geography, social science. Includes a partial list of topics and one activity (geodesic dome) from a module. (Author/SK)

  19. Swedish projects

    International Nuclear Information System (INIS)

    Thunell, J.

    1993-01-01

    The main sources of the financing of Swedish research on gas technology are listed in addition to names of organizations which carry out this research. The titles and descriptions of the projects carried out are presented in addition to lists of reports published with information on prices. (AB)

  20. Descending Projections From The Nucleus Retroambiguus To The Iliopsoas Motoneuronal Cell Groups In The Female Golden Hamster : Possible role in reproductive behavior

    NARCIS (Netherlands)

    Gerrits, Peter O.; Holstege, Gert

    1999-01-01

    In the cat, the nucleus retroambiguus (NRA) projects to expiratory motoneurons in the brainstem and spinal cord. Recently, it has been demonstrated that the NRA sends fibers to a specific set of motoneurons in the lumbosacral cord, which pathway is thought to play a crucial role in mating behavior.

  1. SDN Project

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Rhett [Schweitzer Engineering Laboratories Inc, Pullman, WA (United States)

    2016-12-23

    The SDN Project completed on time and on budget and successfully accomplished 100% of the scope of work outlined in the original Statement of Project Objective (SOPO). The SDN Project formed an alliance between Ameren Corporation, University of Illinois Urbana- Champaign (UIUC), Pacific Northwest National Laboratories (PNNL), and Schweitzer Engineering Laboratories, Inc. (SEL). The objective of the SDN Project is to address Topic Area of Interest 2: Sustain critical energy delivery functions while responding to a cyber-intrusion under Funding Opportunity Announcement DE-FOA-0000797. The goal of the project is to design and commercially release technology that provides a method to sustain critical energy delivery functions during a cyber intrusion and to do this control system operators need the ability to quickly identify and isolate the affected network areas, and re-route critical information and control flows around. The objective of the SDN Project is to develop a Flow Controller that monitors, configures, and maintains the safe, reliable network traffic flows of all the local area networks (LANs) on a control system in the Energy sector. The SDN team identified the core attributes of a control system and produced an SDN flow controller that has the same core attributes enabling networks to be designed, configured and deployed that maximize the whitelisted, deny-bydefault and purpose built networks. This project researched, developed and commercially released technology that: Enables all field networks be to configured and monitored as if they are a single asset to be protected; Enables greatly improved and even precalculated response actions to reliability and cyber events; Supports pre-configured localized response actions tailored to provide resilience against failures and centralized response to cyber-attacks that improve network reliability and availability; Architecturally enables the right subject matter experts, who are usually the information

  2. Project proposals on the creation of Russian-American joint enterprise for investigation, development and manufacture of power plants on the basis of solid oxide fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Smotrov, N.V.; Kleschev, Yu.N.

    1996-04-01

    This paper describes a proposal for a joint Russian-American enterprise for performing scientific investigations, development, and manufacture of fuel cell power plants on the basis of the solid oxide fuel cell. RASOFCo. Russian-American Solid Oxide Fuel Cells Company. RASOFCo will provide the series output of the electrochemical generator (ECG) of 1kW power, then of 5kW and 10kW as well as the development and the output of 10kW power plant with the subsequent output of a power plant of greater power. An ECG based on solid oxide fuel cells uses methane as a fuel. Predicted technical characteristics, market analysis, assessment of potential demands for power plants of low power for Tyumentransgas, participants of the joint enterprise and their founding contributions, strategy for manufacture and financing, and management of RASOFCo are discussed.

  3. Projective geometry and projective metrics

    CERN Document Server

    Busemann, Herbert

    2005-01-01

    The basic results and methods of projective and non-Euclidean geometry are indispensable for the geometer, and this book--different in content, methods, and point of view from traditional texts--attempts to emphasize that fact. Results of special theorems are discussed in detail only when they are needed to develop a feeling for the subject or when they illustrate a general method. On the other hand, an unusual amount of space is devoted to the discussion of the fundamental concepts of distance, motion, area, and perpendicularity.Topics include the projective plane, polarities and conic sectio

  4. Projective measure without projective Baire

    DEFF Research Database (Denmark)

    Schrittesser, David; Friedman, Sy David

    We prove that it is consistent (relative to a Mahlo cardinal) that all projective sets of reals are Lebesgue measurable, but there is a ∆13 set without the Baire property. The complexity of the set which provides a counterexample to the Baire property is optimal.......We prove that it is consistent (relative to a Mahlo cardinal) that all projective sets of reals are Lebesgue measurable, but there is a ∆13 set without the Baire property. The complexity of the set which provides a counterexample to the Baire property is optimal....

  5. Instrument validation project

    International Nuclear Information System (INIS)

    Reynolds, B.A.; Daymo, E.A.; Geeting, J.G.H.; Zhang, J.

    1996-06-01

    Westinghouse Hanford Company Project W-211 is responsible for providing the system capabilities to remove radioactive waste from ten double-shell tanks used to store radioactive wastes on the Hanford Site in Richland, Washington. The project is also responsible for measuring tank waste slurry properties prior to injection into pipeline systems, including the Replacement of Cross-Site Transfer System. This report summarizes studies of the appropriateness of the instrumentation specified for use in Project W-211. The instruments were evaluated in a test loop with simulated slurries that covered the range of properties specified in the functional design criteria. The results of the study indicate that the compact nature of the baseline Project W-211 loop does not result in reduced instrumental accuracy resulting from poor flow profile development. Of the baseline instrumentation, the Micromotion densimeter, the Moore Industries thermocouple, the Fischer and Porter magnetic flow meter, and the Red Valve Pressure transducer meet the desired instrumental accuracy. An alternate magnetic flow meter (Yokagawa) gave nearly identical results as the baseline fischer and Porter. The Micromotion flow meter did not meet the desired instrument accuracy but could potentially be calibrated so that it would meet the criteria. The Nametre on-line viscometer did not meet the desired instrumental accuracy and is not recommended as a quantitative instrument although it does provide qualitative information. The recommended minimum set of instrumentation necessary to ensure the slurry meets the Project W-058 acceptance criteria is the Micromotion mass flow meter and delta pressure cells

  6. Morbidity and mortality according to latest CD4+ cell count among HIV positive individuals in South Africa who enrolled in project Phidisa.

    Directory of Open Access Journals (Sweden)

    Patrick H Maduna

    Full Text Available Short-term morbidity and mortality rates for HIV positive soldiers in the South African National Defence Force (SANDF would inform decisions about deployment and HIV disease management. Risks were determined according to the latest CD4+ cell count and use of antiretroviral therapy (ART for HIV positive individuals in the SANDF and their dependents.A total of 7,114 participants were enrolled and followed for mortality over a median of 4.7 years (IQR: 1.9, 7.1 years. For a planned subset (5,976, progression of disease (POD and grade 4, potentially life-threatening events were also ascertained. CD4+ count and viral load were measured every 3 to 6 months. Poisson regression was used to compare event rates by latest CD4+ count (<50, 50-99, 100-199, 200-349, 350-499, 500+ with a focus on upper three strata, and to estimate relative risks (RRs (ART/no ART. Median entry CD4+ was 207 cells/mm3. During follow-up over 70% were prescribed ART. Over follow-up 1,226 participants died; rates ranged from 57.6 (< 50 cells to 0.8 (500+ cells per 100 person years (py. Compared to those with latest CD4+ 200-349 (2.2/100 py, death rates were significantly lower (p<0.001, as expected, for those with 350-499 (0.9/100 py and with 500+ cells (0.8/100 py. The composite outcome of death, POD or grade 4 events occurred in 2,302 participants (4,045 events; rates were similar in higher CD4+ count strata (9.4 for 350-499 and 7.9 for 500+ cells and lower than those with counts 200-349 cells (13.5 (p<0.001. For those with latest CD4+ 350+ cells, 63% of the composite outcomes (680 of 1,074 were grade 4 events.Rates of morbidity and mortality are lowest among those with CD4+ count of 350 or higher and rates do not differ for those with counts of 350-499 versus 500+ cells. Grade 4 events are the predominant morbidity for participants with CD4+ counts of 350+ cells.

  7. Project Radon

    International Nuclear Information System (INIS)

    Ekholm, S.

    1988-01-01

    The project started in March 1987. The objective is to perform radon monitoring in 2000 dwellings occupied by people employed by State Power Board and to continue to contribute to the development of radon filters. The project participates in developing methods for radon measurement and decontamination and in adapting the methods to large scale application. About 400 so called radon trace measurements (coarse measurement) and about 10 action measurements (decontamination measurement) have been made so far. Experience shows that methods are fully applicable and that the decontamination measures recommended give perfectly satisfactory results. It is also established that most of the houses with high radon levels have poor ventilation Many of them suffer from moisture and mould problems. The work planned for 1988 and 1989 will in addition to measurements be directed towards improvement of the measuring methods. An activity catalogue will be prepared in cooperation with ventilation enterprises. (O.S.)

  8. PARTNER Project

    CERN Multimedia

    Ballantine, A; Dixon-Altaber, H; Dosanjh, M; Kuchina, L

    2011-01-01

    Hadrontherapy uses particle beams to treat tumours located near critical organs and tumours that respond poorly to conventional radiation therapy. It has become evident that there is an emerging need for reinforcing research in hadrontherapy and it is essential to train professionals in this rapidly developing field. PARTNER is a 4-year Marie Curie Training project funded by the European Commission with 5.6 million Euros aimed at the creation of the next generation of experts. Ten academic institutes and research centres and two leading companies are participating in PARTNER, that is coordinated by CERN, forming a unique multidisciplinary and multinational European network. The project offers research and training opportunities to 25 young biologists, engineers, physicians and physicists and is allowing them to actively develop modern techniques for treating cancer in close collaboration with leading European Institutions. For this purpose PARTNER relies on cutting edge research and technology development, ef...

  9. Swedish projects

    International Nuclear Information System (INIS)

    Thunell, J.

    1992-01-01

    A description is given of research activities, concerning heating systems, which were carried out in Sweden during 1991. The main subject areas dealt with under the gas technology group within the area of heating systems were catalytic combustion, polyethylene materials, and gas applications within the paper and pulp industries. A list is given of the titles of project reports published during 1991 and of those begun during that year. Under the Swedish Centre for Gas Technology (SGC), the main areas of research regarding gas applications were polyethylene materials, industrial applications and the reduction of pollutant emissions. A detailed list is given of research projects which were in progress or proposed by March 1992 under the heating system gas technology research group in Sweden. This list also presents the aims and descriptions of the methods, etc. (AB)

  10. AVE project

    International Nuclear Information System (INIS)

    2004-01-01

    During 1998, ANAV began to optimize Human Resources to cope with the ERE and ANA-ANV integration. Project AVE was intended to achieve an orderly transfer of know-how, skills, attitudes and experiences. The most complex part was renovation of personnel with Operating Licenses. Nearly 140 people had joined the organization by late December 2003. This opportunity was seized to draw up a new Training Manual, and a common Initial Training Plan was designed for the two plants, accounting for the singularities of each one. The plan is divided into 5 modules: Common Training, Specific Training, PEI/CAT, Management, and on-the-job Training. The training environments were defined according to the nature of the capabilities to be acquired. Project AVE resulted in the merger of the Asco and Vandellos II Training services. (Author)

  11. Spent Nuclear Fuel project, project management plan

    International Nuclear Information System (INIS)

    Fuquay, B.J.

    1995-01-01

    The Hanford Spent Nuclear Fuel Project has been established to safely store spent nuclear fuel at the Hanford Site. This Project Management Plan sets forth the management basis for the Spent Nuclear Fuel Project. The plan applies to all fabrication and construction projects, operation of the Spent Nuclear Fuel Project facilities, and necessary engineering and management functions within the scope of the project

  12. ARTIST Project

    CSIR Research Space (South Africa)

    Ferguson, K

    2012-10-01

    Full Text Available Biennial Conference Presented by: Keith Ferguson Date: 9 October 2012 Mobile IPTV Broadcasting Platform Consortium: CSIR, UCT, ECA Funded by TIA 2008-2011 ARTIST Project Min time - sacrifice quality Max quality - sacrifice time Application Context... idth > ARTIST Platform Advertiser Client 1 Client 2 Client 3 Client 4 Sport channel News channel Wildlife channel Advert database Transaction database Transcoder Servers Media Switching Servers INTERNET Channel viewing Advert upload...

  13. CARA project

    International Nuclear Information System (INIS)

    Bergallo, Juan E.; Brasnarof, Daniel O.

    2000-01-01

    The CARA (Advanced Fuels for Argentine Reactors) Project successfully completed its first stage, phase one, last year. The performance of this fuel has been partially examined, using CNEA and CONUAR facilities and personnel. With the results obtained in this stage, determined by the corresponding tests and verification of the fuel behavior, the performance of the second stage started immediately afterwards. Works performed and results obtained during the development of the second stage are generally described in this paper. (author)

  14. Polytope projects

    CERN Document Server

    Iordache, Octavian

    2013-01-01

    How do you know what works and what doesn't? This book contains case studies highlighting the power of polytope projects for complex problem solving. Any sort of combinational problem characterized by a large variety of possibly complex constructions and deconstructions based on simple building blocks can be studied in a similar way. Although the majority of case studies are related to chemistry, the method is general and equally applicable to other fields for engineering or science.

  15. Projection Methods

    DEFF Research Database (Denmark)

    Wagner, Falko Jens; Poulsen, Mikael Zebbelin

    1999-01-01

    When trying to solve a DAE problem of high index with more traditional methods, it often causes instability in some of the variables, and finally leads to breakdown of convergence and integration of the solution. This is nicely shown in [ESF98, p. 152 ff.].This chapter will introduce projection...... methods as a way of handling these special problems. It is assumed that we have methods for solving normal ODE systems and index-1 systems....

  16. Project Phaseolus

    International Nuclear Information System (INIS)

    Anon.

    Research carried out through the Phaseolus Project of the 'Centro de Energia Nuclear na Agricultura' (CENA) Piracicaba, Sao Paulo State, Brazil, is described. It comprises the following subject s: plant breeding; nitrogen fixation; tissue cultures; proteins; photosynthetic efficiency; soil-plant interactions; electron microscopy of the golden mosaic virus; pest control; production of 15 N-enriched ammonium sulfate, and determination of elements in the beans plant. (M.A.) [pt

  17. Numatron project

    Energy Technology Data Exchange (ETDEWEB)

    Sugimoto, K [Osaka Univ., Toyonaka (Japan). Dept. of Physics; Hirao, Yasuo

    1977-04-01

    A project of high energy heavy ion acceleration is under consideration. The high energy heavy ions can produce highly condensed states of nuclei. A new phase of nucleus would be seen at the incident energy higher than 140 MeV/nucleon. High energy heavy ions causing high density states and meson emission will produce various new nuclides. Process of formation of atomic elements will be studied. Various fields of science can be also investigated by the high energy heavy ions. Spectroscopic study of multi-valent ions will be made high energy uranium. Study of materials for the fusion reactor is important. Impurity heavy ion from the wall of the fusion reactor may lose the energy of the reactor, and the characteristic features of heavy ions should be investigated. The highly ionized states of atoms are also produced by heavy ion injection into material. Several projects of heavy ion acceleration are in progress in the world. The Numatron project in Japan is to construct a combination machine of a Cockcroft type machine, three linear accelerator and a synchrotron. The planned energy of the machine is 670 MeV/nucleon. Technical problems are under investigation.

  18. FY 2000 report on the results of the infrastructure construction project for spreading high-efficiency fuel cell systems/development of test apparatuses for evaluation of fuel cell systems for automobiles; 2000 nendo kokoritsu nenryo denchi system kiban gijutsu kaihatsu / jidoshayo nenryo denchi system hyoka shiken sochi no kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    This project studies the testing/evaluation methods for spreading fuel cells for automobiles. Described herein are the FY 2000 results. The problems involved in evaluation of the single cell units are classified into those involved in the cell construction and methods of evaluating the operation performances of the single cell units. These problems are analyzed mainly by literature survey. The mode simulation tests will be greatly simplified, if the system can be tested on the bench without being actually boarded on the vehicle. Therefore, this project is aimed at development of a comprehensive mode simulator which can be automatically operated corresponding to the running modes of various countries, to test the performance of FCEV and to examine the effects of each component independently on the vehicle performance. The factors required to reproduce the actual driving states of an FCEV on the bench are analyzed, and the conceptual designs are drawn for the controlling algorithms. It is necessary to standardize the stack and reformer testing methods, in order to evaluate the fuel cell system components. For these objects, the prototype units are constructed to evaluate 10kW direct hydrogen type stacks and 5kW methanol reformers. The units are also constructed to evaluate the high-pressure (1MPa) reformer reactors and hydrogen separation membrane systems. (NEDO)

  19. Fiscal 1999 research cooperation project. Research cooperation on community-oriented practical photovoltaic power systems (Practical methane gas fermentation fuel cell power systems); 1999 nendo metan hakko gas nenryo denchi hatsuden system no jitsuyoka ni kansuru kenkyu kyoryoku

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This report describes the research cooperation with developing countries on practical methane gas fermentation fuel cell power systems in 1999-2002. This research aims to construct the methane gas fermentation fuel cell power facility using livestock excreta which can supply power to the facility and peripheral areas. The facility controls various substance concentrations in waste water within environmental standards, and uses waste as compost. This project is very promising in use of environment-friendly energy, effective use of unused energy and power supply to unelectrified areas for China under serious conditions such as rapid increase in energy demand and various environment problems. There are such various issues to achieve this target as securing livestock (pig breeders) and excreta, and fermentation and recovery of suitable methane gas necessary for fuel cell power systems from excreta. This report is composed of 2 parts, (1) Current use of energy resources and use of unused energy in Guangdong province, and (2) Technical requirements for practical methane gas fermentation fuel cell power systems. (NEDO)

  20. FY 1994 Report on the results of the joint research project for optimum introduction of development of fuel cell technologies for urban energy centers; 1994 nendo toshi energy center nado nenryo denchi gijutsu kaihatsu saiteki donyu chosa seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    Described herein are the FY 1994 results of the joint research project for optimum introduction of development of fuel cell technologies for urban energy centers or the like. The necessary economic conditions for introduction of a fuel cell system to be competitive with the conventional system which individually supplies electric power and heat are 250,000 yen/kW as the construction unit cost, 0.10m{sup 2}/kW as the installation area, 5 years as the cell body life, use of an inexpensive fuel gas (2 to 6 yen/Mcal). Moreover, it is an indoor system which shall have the operational characteristics to follow daily demand fluctuations while operating under the optimum conditions in the urban redevelopment area considered. A 5,000kW-class fuel cell plant burning fuel gas (2 yen/Mcal) will need a total floor area of approximately 400,000 m{sup 2} in an energy-intensive office type demand area. These conditions shall be met in order to economically introduce the 5,000kW-class plant. It is also necessary to compare the plant with the competitive cogeneration plants. The specifications for the prototype now under consideration are sufficient for the energy-saving effect, and it is premised that these specifications and characteristics are secured. (NEDO)

  1. Coloss project

    International Nuclear Information System (INIS)

    2005-01-01

    The COLOSS project was a shared-cost action, co-ordinated by IRSN within the Euratom Research Framework Programme 1998-2002. Started in February 2000, the project lasted three years. The work-programme performed by 19 partners was shaped around complementary activities aimed at improving severe accident codes. Unresolved risk-relevant issues regarding H2 production, melt generation and the source term were studied, through a large number of experiments such as a) dissolution of fresh and high burn-up UO 2 and MOX by molten Zircaloy, b) simultaneous dissolution of UO 2 and ZrO 2 by molten Zircaloy, c) oxidation of U-O-Zr mixtures by steam, d) degradation-oxidation of B 4 C control rods. Significant results have been produced from separate-effects, semi-global and large-scale tests on COLOSS topics. Break-through were achieved on some issues. Nevertheless, more data are needed for consolidation of the modelling on burn-up effects on UO 2 and MOX dissolution and on oxidation of U-O-Zr and B 4 C-metal mixtures. There was experimental evidence that the oxidation of these mixtures can contribute significantly to the large H2 production observed during the reflooding of degraded cores under severe accident conditions. Based on the experimental results obtained on the COLOSS topics, corresponding models were developed and were successfully implemented in several severe accident codes. Upgraded codes were then used for plant calculations to evaluate the consequences of new models on key severe accident sequences occurring in different plants designs involving B 4 C control rods (EPR, BWR, VVER- 1000) as well as in the TMI-2 accident. The large series of plant calculations involved sensitivity studies and code benchmarks. Main severe accident codes in use in the EU for safety studies were used such as ICARE/CATHARE, SCDAP/RELAP5, ASTEC, MELCOR and MAAP4. This activity enabled: a) the assessment of codes to calculate core degradation, b) the identification of main

  2. The Start-Up of the first Hematopoietic Stem Cell Transplantation Center in the Iraqi Kurdistan: a Capacity-Building Cooperative Project by the Hiwa Cancer Hospital, Sulaymaniyah, and the Italian Agency for Development Cooperation: an Innovative Approach.

    Science.gov (United States)

    Majolino, Ignazio; Othman, Dosti; Rovelli, Attilio; Hassan, Dastan; Rasool, Luqman; Vacca, Michele; Abdalrahman, Nigar; Abdullah, Chra; Ahmed, Zhalla; Ali, Dlir; Ali, Kosar; Broggi, Chiara; Calabretta, Cinzia; Canesi, Marta; Ciabatti, Gloria; Del Fante, Claudia; De Sapio, Elisabetta; Dore, Giovanna; Frigato, Andrea; Gabriel, Marcela; Ipsevich, Francesco; Kareem, Harem; Karim, Dana; Leone, Rosa; Mahmood, Tavan; Manna, Annunziata; Massei, Maria Speranza; Mastria, Andrea; Mohammed, Dereen; Mohammed, Rebar; Najmaddin, Khoshnaw; Noori, Diana; Ostuni, Angelo; Palmas, Angelo; Possenti, Marco; Qadir, Ali; Real, Giorgio; Shrif, Rebwar; Valdatta, Caterina; Vasta, Stefania; Verna, Marta; Vittori, Mariangela; Yousif, Awder; Zallio, Francesco; Calisti, Alessandro; Quattrocchi, Sergio; Girmenia, Corrado

    2017-01-01

    We describe the entire process leading to the start-up of a hematopoietic stem cell transplantation center at the Hiwa Cancer Hospital, in the city of Sulaymaniyah, Kurdistan Iraqi Region. This capacity building project was funded by the Italian Development Cooperation Agency and implemented with the support of the volunteer work of Italian professionals, either physicians, nurses, biologists and technicians. The intervention started in April 2016, was based exclusively on training and coaching on site, that represent a significant innovative approach, and led to a first autologous transplant in June 2016 and to the first allogeneic transplant in October. At the time of reporting, 9 months from the initiation of the project, 18 patients have been transplanted, 15 with an autologous and 3 with an allogeneic graft. The center at the HCH represents the first transplantation center in Kurdistan and the second in wide Iraq. We conclude that international development cooperation may play an important role also in the field of high-technology medicine, and contribute to improved local centers capabilities through country to country scientific exchanges. The methodology to realize this project is innovative, since HSCT experts are brought as volunteers to the center(s) to be started, while traditionally it is the opposite, i.e. the local professionals to be trained are brought to the specialized center(s).

  3. Sun light European Project

    Science.gov (United States)

    Soubielle, Marie-Laure

    2015-04-01

    innovative devices. Outcome: In this project students will carry out various experiments to have a better optical understanding of sunlight. They will shoot tutorials and use these experiments to make a digital pen. Solar Impulse Project Model aircraft Technology, Electricity and English project Context : Solar Impulse is a solar plane that flew around the world with no stop using only the energy of the solar cells situated on its wings. The plane only requires an external source energy for take off unlike gliders. The pilot in the cockpit is one of the conception engineers. The plane can store enough energy for an 8-hour night flight. Outcome : This project will create a tutorial and a model aircraft of the plane Solar Impulse with solar cells providing energy for 4 engines, batteries, LED lighting and a tension reader. This plane will not fly.

  4. Proceedings of the Flat-plate Solar Array Project Research Forum on the High-speed Growth and Characterization of Crystals for Solar Cells

    Science.gov (United States)

    Dumas, K. A. (Editor)

    1984-01-01

    Theoretical and experimental phenomena, applications, and characterization including stress/strain and other problem areas that limit the rate of growth of crystals suitable for processing into efficient, cost-effective solar cells are discussed. Melt spinning, ribbon growth, rapid solidification, laser recrystallization, and ignot growth of silicon and metals are also discussed.

  5. Delayed post-treatment with bone marrow-derived mesenchymal stem cells is neurorestorative of striatal medium-spiny projection neurons and improves motor function after neonatal rat hypoxia-ischemia.

    Science.gov (United States)

    Cameron, Stella H; Alwakeel, Amr J; Goddard, Liping; Hobbs, Catherine E; Gowing, Emma K; Barnett, Elizabeth R; Kohe, Sarah E; Sizemore, Rachel J; Oorschot, Dorothy E

    2015-09-01

    Perinatal hypoxia-ischemia is a major cause of striatal injury and may lead to cerebral palsy. This study investigated whether delayed administration of bone marrow-derived mesenchymal stem cells (MSCs), at one week after neonatal rat hypoxia-ischemia, was neurorestorative of striatal medium-spiny projection neurons and improved motor function. The effect of a subcutaneous injection of a high-dose, or a low-dose, of MSCs was investigated in stereological studies. Postnatal day (PN) 7 pups were subjected to hypoxia-ischemia. At PN14, pups received treatment with either MSCs or diluent. A subset of high-dose pups, and their diluent control pups, were also injected intraperitoneally with bromodeoxyuridine (BrdU), every 24h, on PN15, PN16 and PN17. This permitted tracking of the migration and survival of neuroblasts originating from the subventricular zone into the adjacent injured striatum. Pups were euthanized on PN21 and the absolute number of striatal medium-spiny projection neurons was measured after immunostaining for DARPP-32 (dopamine- and cAMP-regulated phosphoprotein-32), double immunostaining for BrdU and DARPP-32, and after cresyl violet staining alone. The absolute number of striatal immunostained calretinin interneurons was also measured. There was a statistically significant increase in the absolute number of DARPP-32-positive, BrdU/DARPP-32-positive, and cresyl violet-stained striatal medium-spiny projection neurons, and fewer striatal calretinin interneurons, in the high-dose mesenchymal stem cell (MSC) group compared to their diluent counterparts. A high-dose of MSCs restored the absolute number of these neurons to normal uninjured levels, when compared with previous stereological data on the absolute number of cresyl violet-stained striatal medium-spiny projection neurons in the normal uninjured brain. For the low-dose experiment, in which cresyl violet-stained striatal medium-spiny neurons alone were measured, there was a lower statistically

  6. California Hydrogen Infrastructure Project

    Energy Technology Data Exchange (ETDEWEB)

    Heydorn, Edward C

    2013-03-12

    Air Products and Chemicals, Inc. has completed a comprehensive, multiyear project to demonstrate a hydrogen infrastructure in California. The specific primary objective of the project was to demonstrate a model of a real-world retail hydrogen infrastructure and acquire sufficient data within the project to assess the feasibility of achieving the nation's hydrogen infrastructure goals. The project helped to advance hydrogen station technology, including the vehicle-to-station fueling interface, through consumer experiences and feedback. By encompassing a variety of fuel cell vehicles, customer profiles and fueling experiences, this project was able to obtain a complete portrait of real market needs. The project also opened its stations to other qualified vehicle providers at the appropriate time to promote widespread use and gain even broader public understanding of a hydrogen infrastructure. The project engaged major energy companies to provide a fueling experience similar to traditional gasoline station sites to foster public acceptance of hydrogen. Work over the course of the project was focused in multiple areas. With respect to the equipment needed, technical design specifications (including both safety and operational considerations) were written, reviewed, and finalized. After finalizing individual equipment designs, complete station designs were started including process flow diagrams and systems safety reviews. Material quotes were obtained, and in some cases, depending on the project status and the lead time, equipment was placed on order and fabrication began. Consideration was given for expected vehicle usage and station capacity, standard features needed, and the ability to upgrade the station at a later date. In parallel with work on the equipment, discussions were started with various vehicle manufacturers to identify vehicle demand (short- and long-term needs). Discussions included identifying potential areas most suited for hydrogen fueling

  7. Project Exodus

    Science.gov (United States)

    1990-01-01

    Project Exodus is an in-depth study to identify and address the basic problems of a manned mission to Mars. The most important problems concern propulsion, life support, structure, trajectory, and finance. Exodus will employ a passenger ship, cargo ship, and landing craft for the journey to Mars. These three major components of the mission design are discussed separately. Within each component the design characteristics of structures, trajectory, and propulsion are addressed. The design characteristics of life support are mentioned only in those sections requiring it.

  8. CAREM Project

    International Nuclear Information System (INIS)

    Ishida, Viviana; Gomez, Silvia

    2001-01-01

    CAREM project consists on the development and design of an advanced nuclear power plant. CAREM is a very low power innovative reactor conceived with new generation design solutions. Based on an indirect cycle integrated light water reactor using enriched uranium, CAREM has some distinctive features that greatly simplify the reactor and also contribute to a high level of safety: integrated primary system, primary system cooling by natural convection, self pressurization, and passive safety systems. In order to verify its innovative features the construction of a prototype is planned. (author)

  9. PORTNUS Project

    Energy Technology Data Exchange (ETDEWEB)

    Loyal, Rebecca E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-07-14

    The objective of the Portunus Project is to create large, automated offshore ports that will the pace and scale of international trade. Additionally, these ports would increase the number of U.S. domestic trade vessels needed, as the imported goods would need to be transported from these offshore platforms to land-based ports such as Boston, Los Angeles, and Newark. Currently, domestic trade in the United States can only be conducted by vessels that abide by the Merchant Marine Act of 1920 – also referred to as the Jones Act. The Jones Act stipulates that vessels involved in domestic trade must be U.S. owned, U.S. built, and manned by a crew made up of U.S. citizens. The Portunus Project would increase the number of Jones Act vessels needed, which raises an interesting economic concern. Are Jones Act ships more expensive to operate than foreign vessels? Would it be more economically efficient to modify the Jones Act and allow vessels manned by foreign crews to engage in U.S. domestic trade? While opposition to altering the Jones Act is strong, it is important to consider the possibility that ship-owners who employ foreign crews will lobby for the chance to enter a growing domestic trade market. Their success would mean potential job loss for thousands of Americans currently employed in maritime trade.

  10. FLORAM project

    Energy Technology Data Exchange (ETDEWEB)

    Zulauf, W E [Sao Paolos Environmental Secretariat, Sao Paolo (Brazil); Goelho, A S.R. [Riocell, S.A. (Brazil); Saber, A [IEA-Instituto de Estudos Avancados (Brazil); and others

    1996-12-31

    The project FLORAM was formulated at the `Institute for Advanced Studies` of the University of Sao Paulo. It aims at decreasing the level of carbon dioxide in the atmosphere and thus curbing the green-house effect by way of a huge effort of forestation and reforestation. The resulting forests when the trees mature, will be responsible for the absorption of about 6 billion tons of excess carbon. It represents 5 % of the total amount of CO{sub 2} which is in excess in the earth`s atmosphere and represents 5 % of the available continental surfaces which can be forested as well. Therefore, if similar projects are implemented throughout the world, in theory all the exceeding CO{sub 2}, responsible for the `greenhouse effect`, (27 % or 115 billion tons of carbon) would be absorbed. Regarding this fact, there would be a 400 million hectar increase of growing forests. FLORAM in Brazil aims to plant 20.000.000 ha in 2 years at a cost of 20 billion dollars. If it reaches its goals that will mean that Brazil will have reforested an area almost half as big as France. (author)

  11. FLORAM project

    Energy Technology Data Exchange (ETDEWEB)

    Zulauf, W.E. [Sao Paolos Environmental Secretariat, Sao Paolo (Brazil); Goelho, A.S.R. [Riocell, S.A. (Brazil); Saber, A. [IEA-Instituto de Estudos Avancados (Brazil)] [and others

    1995-12-31

    The project FLORAM was formulated at the `Institute for Advanced Studies` of the University of Sao Paulo. It aims at decreasing the level of carbon dioxide in the atmosphere and thus curbing the green-house effect by way of a huge effort of forestation and reforestation. The resulting forests when the trees mature, will be responsible for the absorption of about 6 billion tons of excess carbon. It represents 5 % of the total amount of CO{sub 2} which is in excess in the earth`s atmosphere and represents 5 % of the available continental surfaces which can be forested as well. Therefore, if similar projects are implemented throughout the world, in theory all the exceeding CO{sub 2}, responsible for the `greenhouse effect`, (27 % or 115 billion tons of carbon) would be absorbed. Regarding this fact, there would be a 400 million hectar increase of growing forests. FLORAM in Brazil aims to plant 20.000.000 ha in 2 years at a cost of 20 billion dollars. If it reaches its goals that will mean that Brazil will have reforested an area almost half as big as France. (author)

  12. SISCAL project

    Science.gov (United States)

    Santer, Richard P.; Fell, Frank

    2003-05-01

    The first "ocean colour" sensor, Coastal Zone Color Scanner (CZCS), was launched in 1978. Oceanographers learnt a lot from CZCS but it remained a purely scientific sensor. In recent years, a new generation of satellite-borne earth observation (EO) instruments has been brought into space. These instruments combine high spectral and spatial resolution with revisiting rates of the order of one per day. More instruments with further increased spatial, spectral and temporal resolution will be available within the next years. In the meantime, evaluation procedures taking advantage of the capabilities of the new instruments were derived, allowing the retrieval of ecologically important parameters with higher accuracy than before. Space agencies are now able to collect and to process satellite data in real time and to disseminate them via the Internet. It is therefore meanwhile possible to envisage using EO operationally. In principle, a significant demand for EO data products on terrestrial or marine ecosystems exists both with public authorities (environmental protection, emergency management, natural resources management, national parks, regional planning, etc) and private companies (tourist industry, insurance companies, water suppliers, etc). However, for a number of reasons, many data products that can be derived from the new instruments and methods have not yet left the scientific community towards public or private end users. It is the intention of the proposed SISCAL (Satellite-based Information System on Coastal Areas and Lakes) project to contribute to the closure of the existing gap between space agencies and research institutions on one side and end users on the other side. To do so, we intend to create a data processor that automatically derives and subsequently delivers over the Internet, in Near-Real-Time (NRT), a number of data products tailored to individual end user needs. The data products will be generated using a Geographical Information System (GIS

  13. Project Financing

    OpenAIRE

    S. GATTI

    2005-01-01

    Στην εισαγωγή της παρούσας εργασίας δίνεται ο ορισμός του project financing, τα ιστορικά στοιχεία και οι τάσεις αγοράς του. Στο πρώτο κεφάλαιο αναφέρεται γιατί οι εταιρείες προτιμούν την χρηματοδότηση με project financing. Γίνεται λόγος για τα πλεονεκτήματά του έναντι της άμεσης χρηματοδότησης, καθώς και για τα μειονεκτήματα του project financing. Στο δεύτερο κεφάλαιο παρουσιάζονται τα χρηματοοικονομικά στοιχεία και ο ρόλος του χρηματοοικονομικού συμβούλου. Στην τρίτη ενότητα γίνεται η αναγνώ...

  14. Fiscal 1996 survey report. Data collection and evaluation analysis in the project on field tests on the fuel cell generation; 1996 nendo kenkyu hokokusho. Nenryo denchi hatsuden field test jigyo ni okeru data shuyaku oyobi hyoka kaiseki

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The paper installed fuel cell power generation equipment experimentally at various facilities which are the final diffusion form of the new energy power generation, conducted long-term operation under the actual load, collected/analyzed various data, arranged them as data useful for full scale introduction/diffusion, aiming at forming the base for general diffusion of the fuel cell power generation. The number of the systems installed for field test execution has been 24 places/28 units since the start of the project, and the system capacity totaled 4,250kW. The actual operation hours in five years are 6,000-28,000. In fiscal 1996, the average cumulative accumulated operational rate was approximately 68%, a little over that in fiscal 1995, 65%. The average load factor was 69% in fiscal 1995 and 70% in fiscal 1996. The utilization rate increased as a whole to about 57% on average if seeing only fiscal 1996, as compared with that in fiscal 1995, about 48%. The power generating efficiency was approximately 34% on average. As to the status of shutdown of the fuel cell power generation, the paper surveyed the average interval of failure, the rate of frequency of shutdown, the analysis of shutdown, etc. 250 figs., 29 tabs.

  15. Project: Ultracentrifuges

    International Nuclear Information System (INIS)

    Olea C, O.

    1990-07-01

    The trans elastic ultracentrifuge of magnetic suspension, is an instrument that arose of an interdisciplinary group directed by the Dr. James Clark Keith where it was projected, designed and built a centrifuge that didn't exist, to be applied in forced diffusion of uranium, like one of the many application fields. The written present, has as purpose to give to know the fundamental physical principles of this technology, its fundamental characteristics of design, the application of this in the separation process of isotopes, as well as the previous studies and essential control parameters in the experimental processes, the same thing that, the most outstanding results and the detection systems used in the confirmation and finally, the carried out potential applications of the principles of the ultracentrifugation technology. (Author)

  16. EUROTRAC projects

    International Nuclear Information System (INIS)

    Slanina, J.; Arends, B.G.; Wyers, G.P.

    1992-07-01

    The projects discussed are BIATEX (BIosphere-ATmosphere EXchange of pollutants), ACE (Acidity in Clouds Experiment) and GCE (Ground-based Cloud Experiment). ECN also coordinates BIATEX and contributes to the coordination of EUROTRAC. Research in BIATEX is aimed at the development of equipment, by which atmosphere-surface interactions of air pollution can be quantified. A ion chromatograph, connected to a rotating denuder, is developed to be applicated in the field for on-line analysis of denuder extracts and other samples. To investigate dry deposition of ammonia a continuous-flow denuder has been developed. A thermodenuder system to measure the concentrations of HNO 3 and NH 4 NO 3 in the ambient air is optimized to determine depositions and is part of the ECN monitoring station in Zegveld, Netherlands. An aerosol separation technique, based on a cyclone separator, has also been developed. All this equipment has been used in field experiments above wheat and heather. An automated monitoring station for long-term investigations of NH 3 , HNO 3 and SO 2 dry deposition on grassland and the impact of the deposition on the presence and composition of water films has been set up and fully tested. Research in GCE concerns the uptake and conversion of air pollution in clouds (cloud chemistry). Measuring equipment from several collaborative institutes has been specified and calibrated in a cloud chamber at ECN. The ECN contribution is the determination of the gas phase composition and the micro-physical characterization of the clouds. Measurement campaigns were carried out in the Po area (Italy) in fog, and in Kleiner Feldberg near Frankfurt, Germany, in orographic clouds. Estimations are given of the deposition of fog water and cloud water on forests in the Netherlands and the low mountain range in Germany. The project ACE was not started because of financial reasons and will be reconsidered. 26 figs., 1 tab., 3 apps., 34 refs

  17. Electricity from photovoltaic solar cells. Flat-Plate Solar Array Project of the US Department of Energy's National Photovoltaics Program: 10 years of progress

    Science.gov (United States)

    Christensen, Elmer

    1985-01-01

    The objectives were to develop the flat-plate photovoltaic (PV) array technologies required for large-scale terrestrial use late in the 1980s and in the 1990s; advance crystalline silicon PV technologies; develop the technologies required to convert thin-film PV research results into viable module and array technology; and to stimulate transfer of knowledge of advanced PV materials, solar cells, modules, and arrays to the PV community. Progress reached on attaining these goals, along with future recommendations are discussed.

  18. Photovoltaic technologies and the genesis project

    International Nuclear Information System (INIS)

    Kuwano, Y.

    1994-01-01

    In this paper, the author first presents briefly global environmental problems and energy problems, as well as recent trends in representative types of solar cell. Next, he gives examples of applications for these solar cells, and finally discusses future prospects for solar cells in the form of the GENESIS project. (TEC). 12 figs., 4 refs

  19. Project Success in IT Project Management

    OpenAIRE

    Siddiqui, Farhan Ahmed

    2010-01-01

    The rate of failed and challenged Information Technology (IT) projects is too high according to the CHAOS Studies by the Standish Group and the literature on project management (Standish Group, 2008). The CHAOS Studies define project success as meeting the triple constraints of scope, time, and cost. The criteria for project success need to be agreed by all parties before the start of the project and constantly reviewed as the project progresses. Assessing critical success factors is another ...

  20. Project LASER

    Science.gov (United States)

    1990-01-01

    NASA formally launched Project LASER (Learning About Science, Engineering and Research) in March 1990, a program designed to help teachers improve science and mathematics education and to provide 'hands on' experiences. It featured the first LASER Mobile Teacher Resource Center (MTRC), is designed to reach educators all over the nation. NASA hopes to operate several MTRCs with funds provided by private industry. The mobile unit is a 22-ton tractor-trailer stocked with NASA educational publications and outfitted with six work stations. Each work station, which can accommodate two teachers at a time, has a computer providing access to NASA Spacelink. Each also has video recorders and photocopy/photographic equipment for the teacher's use. MTRC is only one of the five major elements within LASER. The others are: a Space Technology Course, to promote integration of space science studies with traditional courses; the Volunteer Databank, in which NASA employees are encouraged to volunteer as tutors, instructors, etc; Mobile Discovery Laboratories that will carry simple laboratory equipment and computers to provide hands-on activities for students and demonstrations of classroom activities for teachers; and the Public Library Science Program which will present library based science and math programs.

  1. Project Longshot

    Science.gov (United States)

    West, J. Curtis; Chamberlain, Sally A.; Stevens, Robert; Pagan, Neftali

    1989-01-01

    Project Longshot is an unmanned probe to our nearest star system, Alpha Centauri, 4.3 light years away. The Centauri system is a trinary system consisting of two central stars (A and B) orbiting a barycenter, and a third (Proxima Centauri) orbiting the two. The system is a declination of -67 degrees. The goal is to reach the Centauri system in 50 years. This time space was chosen because any shorter time would be impossible of the relativistic velocities involved, and any greater time would be impossible because of the difficulty of creating a spacecraft with such a long lifetime. Therefore, the following mission profile is proposed: (1) spacecraft is assembled in Earth orbit; (2) spacecraft escapes Earth and Sun in the ecliptic with a single impulse maneuver; (3) spacecraft changed declination to point toward Centauri system; (4) spacecraft accelerates to 0.1c; (5) spacecraft coasts at 0.1c for 41 years; (6) spacecraft decelerates upon reaching Centauri system; and (7) spacecraft orbits Centauri system, conducts investigations, and relays data to Earth. The total time to reach the Centauri system, taking into consideration acceleration and deceleration, will be approximately 50 years.

  2. Reproducible diagnosis of chronic lymphocytic leukemia by flow cytometry: An European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) Harmonisation project.

    Science.gov (United States)

    Rawstron, Andy C; Kreuzer, Karl-Anton; Soosapilla, Asha; Spacek, Martin; Stehlikova, Olga; Gambell, Peter; McIver-Brown, Neil; Villamor, Neus; Psarra, Katherina; Arroz, Maria; Milani, Raffaella; de la Serna, Javier; Cedena, M Teresa; Jaksic, Ozren; Nomdedeu, Josep; Moreno, Carol; Rigolin, Gian Matteo; Cuneo, Antonio; Johansen, Preben; Johnsen, Hans E; Rosenquist, Richard; Niemann, Carsten Utoft; Kern, Wolfgang; Westerman, David; Trneny, Marek; Mulligan, Stephen; Doubek, Michael; Pospisilova, Sarka; Hillmen, Peter; Oscier, David; Hallek, Michael; Ghia, Paolo; Montserrat, Emili

    2018-01-01

    The diagnostic criteria for CLL rely on morphology and immunophenotype. Current approaches have limitations affecting reproducibility and there is no consensus on the role of new markers. The aim of this project was to identify reproducible criteria and consensus on markers recommended for the diagnosis of CLL. ERIC/ESCCA members classified 14 of 35 potential markers as "required" or "recommended" for CLL diagnosis, consensus being defined as >75% and >50% agreement, respectively. An approach to validate "required" markers using normal peripheral blood was developed. Responses were received from 150 participants with a diagnostic workload >20 CLL cases per week in 23/150 (15%), 5-20 in 82/150 (55%), and 97% concordance with current approaches. A pilot study to validate staining quality was completed in 11 centers. Markers considered as "required" for the diagnosis of CLL by the participants in this study (CD19, CD5, CD20, CD23, Kappa, and Lambda) are consistent with current diagnostic criteria and practice. Importantly, a reproducible approach to validate and apply these markers in individual laboratories has been identified. Finally, a consensus "recommended" panel of markers to refine diagnosis in borderline cases (CD43, CD79b, CD81, CD200, CD10, and ROR1) has been defined and will be prospectively evaluated. © 2017 International Clinical Cytometry Society. © 2017 The Authors. Cytometry Part B: Clinical Cytometry published by Wiley Periodicals, Inc. on behalf of International Clinical Cytometry Society.

  3. Achievement report on research and development in the Sunshine Project in fiscal 1979. Research on fuel cells (Research on aqueous alkaline solution electrolyte fuel cells); 1979 nendo nenryo denchi no kenkyu seika hokokusho. Arukari suiyoeki denkaishitsu nenryo denchi no kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1980-03-01

    This paper describes achievements in fiscal 1979 in research on aqueous alkaline solution electrolyte fuel cells. Trial fabrication and tests for an oxygen electrode were performed on a catalytic electrode added with silver using carbonblack and graphites as carriers having excellent corrosion resistance and large surface area. Characteristics not inferior to electrodes using activated carbon as a carrier were obtained in both of the initial characteristics and continuous discharge characteristics. A platinum added electrode also showed the same performance as the silver added electrode. A hydrogen electrode containing Zr and iron among those containing Raney-Ni was found to have high oxidation resistance and stability in terms of life. A platinum added electrode using graphite as a carrier provided satisfactory initial characteristics as a hydrogen electrode. Research on a single cell construction has used and tested eight-cell laminated cells with an area of 1,000 cm{sup 2} using bipolar sheets made of carbon. The test verified appropriate the removal of produced water and heat using mainly the hydrogen circulation, which has been discussed in the summary design. The paper describes heat cycles, for which tests of ten and odds times in total were performed to have demonstrated that they are free of any anomaly. Furthermore, a manifold was attached as a means to improve the volume efficiency. Its function was also tested. (NEDO)

  4. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Nitin S. Baliga and Leroy Hood

    2008-11-12

    The proposed overarching goal for this project was the following: Data integration, simulation and visualization will facilitate metabolic and regulatory network prediction, exploration, and formulation of hypotheses. We stated three specific aims to achieve the overarching goal of this project: (1) Integration of multiple levels of information such as mRNA and protein levels, predicted protein-protein interactions/associations and gene function will enable construction of models describing environmental response and dynamic behavior. (2) Flexible tools for network inference will accelerate our understanding of biological systems. (3) Flexible exploration and queries of model hypotheses will provide focus and reveal novel dependencies. The underlying philosophy of these proposed aims is that an iterative cycle of experiments, experimental design, and verification will lead to a comprehensive and predictive model that will shed light on systems level mechanisms involved in responses elicited by living systems upon sensing a change in their environment. In the previous years report we demonstrated considerable progress in development of data standards, regulatory network inference and data visualization and exploration. We are pleased to report that several manuscripts describing these procedures have been published in top international peer reviewed journals including Genome Biology, PNAS, and Cell. The abstracts of these manuscripts are given and they summarize our accomplishments in this project.

  5. Project Success in Agile Development Software Projects

    Science.gov (United States)

    Farlik, John T.

    2016-01-01

    Project success has multiple definitions in the scholarly literature. Research has shown that some scholars and practitioners define project success as the completion of a project within schedule and within budget. Others consider a successful project as one in which the customer is satisfied with the product. This quantitative study was conducted…

  6. Ace Project as a Project Management Tool

    Science.gov (United States)

    Cline, Melinda; Guynes, Carl S.; Simard, Karine

    2010-01-01

    The primary challenge of project management is to achieve the project goals and objectives while adhering to project constraints--usually scope, quality, time and budget. The secondary challenge is to optimize the allocation and integration of resources necessary to meet pre-defined objectives. Project management software provides an active…

  7. Organizations, projects and culture

    NARCIS (Netherlands)

    J. van Cleeff; Pieter van Nispen tot Pannerden

    2016-01-01

    Purpose: to explore and demonstrate the effects of organizational culture on projects, in particular project culture and project management style. Methodology/approach: descriptive and explorative; through students’ groups. Findings: the cultural relationship between organizations, their projects

  8. Emergency Department Sickle Cell Assessment of Needs and Strengths (ED-SCANS), a Focus Group and Decision Support Tool Development Project

    Science.gov (United States)

    Tanabe, Paula; Reddin, Christopher; Thornton, Victoria L.; Todd, Knox H.; Wun, Ted; Lyons, John S.

    2010-01-01

    Objectives A decision support tool may guide emergency clinicians in recognizing assessment, analgesic and overall management, and health service delivery needs for patients with sickle cell disease (SCD) in the emergency department (ED). We aimed to identify data and process elements important in making decisions regarding evaluation and management of adult patients in the ED with painful episodes of sickle cell disease. Methods Qualitative methods using a series of focus groups and grounded theory were used. Eligible participants included adult clients with SCD, and emergency physicians and nurses with a minimum of one year of experience providing care to patients with SCD in the ED. Patients were recruited in conjunction with annual SCD meetings, and providers included clinicians who were and were not affiliated with sickle cell centers. Groups were conducted until saturation was reached, and included a total of two patient groups, three physician groups, and two nurse groups. Focus groups were held in New York, Durham, Chicago, New Orleans, and Denver. Clinician participants were asked the following three questions to guide the discussion: 1) what information would be important to know about patients with SCD in the ED setting to effectively care for them and help you identify patient analgesic, treatment, and referral needs? 2) what treatment decisions would you make with this information? and 3) what characteristics would a decision support tool need to have to make it meaningful and useful? Client participants were asked the same questions with re-wording to reflect what they believed providers should know to provide the best care, and what they should do with the information. All focus groups were audio taped and transcribed. The constant comparative method was used to analyze the data. Two coders independently coded participant responses and identified focal themes based on the key questions. An investigator and assistant independently reviewed the

  9. Nicotinamide Promotes Adipogenesis in Umbilical Cord-Derived Mesenchymal Stem Cells and Is Associated with Neonatal Adiposity: The Healthy Start BabyBUMP Project.

    Directory of Open Access Journals (Sweden)

    Allison L B Shapiro

    Full Text Available The cellular mechanisms whereby excess maternal nutrition during pregnancy increases adiposity of the offspring are not well understood. However, nicotinamide (NAM, a fundamental micronutrient that is important in energy metabolism, has been shown to regulate adipogenesis through inhibition of SIRT1. Here we tested three novel hypotheses: 1 NAM increases the adipogenic response of human umbilical cord tissue-derived mesenchymal stem cells (MSCs through a SIRT1 and PPARγ pathway; 2 lipid potentiates the NAM-enhanced adipogenic response; and 3 the adipogenic response to NAM is associated with increased percent fat mass (%FM among neonates. MSCs were derived from the umbilical cord of 46 neonates born to non-obese mothers enrolled in the Healthy Start study. Neonatal %FM was measured using air displacement plethysmography (Pea Pod shortly after birth. Adipogenic differentiation was induced for 21 days in the 46 MSC sets under four conditions, +NAM (3mM/-lipid (200 μM oleate/palmitate mix, +NAM/+lipid, -NAM/+lipid, and vehicle-control (-NAM/-lipid. Cells incubated in the presence of NAM had significantly higher PPARγ protein (+24%, p <0.01, FABP4 protein (+57%, p <0.01, and intracellular lipid content (+51%, p <0.01. Lipid did not significantly increase either PPARγ protein (p = 0.98 or FABP4 protein content (p = 0.82. There was no evidence of an interaction between NAM and lipid on adipogenic response of PPARγ or FABP4 protein (p = 0.99 and p = 0.09. In a subset of 9 MSC, SIRT1 activity was measured in the +NAM/-lipid and vehicle control conditions. SIRT1 enzymatic activity was significantly lower (-70%, p <0.05 in the +NAM/-lipid condition than in vehicle-control. In a linear model with neonatal %FM as the outcome, the percent increase in PPARγ protein in the +NAM/-lipid condition compared to vehicle-control was a significant predictor (β = 0.04, 95% CI 0.01-0.06, p <0.001. These are the first data to support that chronic NAM exposure

  10. Evaluation of Project Achievements in VOMARE -project

    OpenAIRE

    Kokkarinen, Eeva

    2011-01-01

    The purpose of the thesis is to study the achievements of VOMARE –project from the Finnish Lifeboat Institutions perspective. The organisation is a roof organisation for voluntary maritime rescue operation in Finland. The Finnish Lifeboat Institution is a lead partner in VOMARE –project which is EU funded project and the aim of the project is to start voluntary rescue operations in Estonia. The theoretical part of the work is divided into two main categories; project management and planni...

  11. Electrorefining cell evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Bronson, M.C.; Thomas, R.L. (ed.)

    1989-04-14

    Operational characteristics of the LANL electrorefining cell, a modified LANL electrorefining cell, and an advanced electrorefining cell (known as the CRAC cell) were determined. Average process yields achieved were: 75% for the LANL cell, 82% for the modified LANL cell, and 86% for the CRAC cell. All product metal from the LANL and modified LANL cells was within foundry specifications. Metal from one run in the CRAC cell exceeded foundry specifications for tantalum. The LANL and modified LANL cells were simple in design and operation, but product separation was more labor intensive than with the CRAC cell. The CRAC cell was more complicated in design but remained relatively simple in operation. A decision analysis concluded that the modified LANL cell was the preferred cell. It was recommended that the modified LANL cell be implemented by the Plutonium Recovery Project at Rocky Flats and that development of the CRAC cell continue. 8 refs., 22 figs., 12 tabs.

  12. All projects related to Canada | Page 2 | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Bolivian public justice performance research study. Project ... A functioning immune system is critical for successful treatment of cancer. Region: ... Regulation of stem-cell mediated host immunity by the sphingolipid pathway. Project.

  13. Project Plan Remote Target Fabrication Refurbishment Project

    International Nuclear Information System (INIS)

    Bell, Gary L.; Taylor, Robin D.

    2009-01-01

    In early FY2009, the DOE Office of Science - Nuclear Physics Program reinstated a program for continued production of 252 Cf and other transcurium isotopes at the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). The FY2009 major elements of the workscope are as follows: (1) Recovery and processing of seven transuranium element targets undergoing irradiation at the High Flux Isotope Reactor (HFIR) at ORNL; (2) Development of a plan to manufacture new targets for irradiation beginning in early- to mid-FY10 to supply irradiated targets for processing Campaign 75 (TRU75); and (3) Refurbishment of the target manufacturing equipment to allow new target manufacture in early FY10 The 252 Cf product from processing Campaign 74 (recently processed and currently shipping to customers) is expected to supply the domestic demands for a period of approximately two years. Therefore it is essential that new targets be introduced for irradiation by the second quarter of FY10 (HFIR cycle 427) to maintain supply of 252 Cf; the average irradiation period is ∼10 HFIR cycles, requiring about 1.5 calendar years. The strategy for continued production of 252 Cf depends upon repairing and refurbishing the existing pellet and target fabrication equipment for one additional target production campaign. This equipment dates from the mid-1960s to the late 1980s, and during the last target fabrication campaign in 2005- 2006, a number of component failures and operations difficulties were encountered. It is expected that following the target fabrication and acceptance testing of the targets that will supply material for processing Campaign 75 a comprehensive upgrade and replacement of the remote hot-cell equipment will be required prior to subsequent campaigns. Such a major refit could start in early FY 2011 and would take about 2 years to complete. Scope and cost estimates for the repairs described herein were developed, and authorization for the work

  14. GreenSynFuels. Economical and technological statement regarding integration and storage of renewable energy in the energy sector by production of green synthetic fuels for utilization in fuel cells. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Lebaek, J. (Danish Technological Institute, Aarhus (Denmark)); Boegild Hansen, J. (Haldor Topsoee, Kgs. Lyngby (Denmark)); Mogensen, Mogens (Technical Univ. of Denmark, Risoe National Lab. for Sustainable Energy, Roskilde (Denmark)) (and others)

    2011-03-15

    The purpose of the project is to select and validate technology concepts for the establishment of a Danish production of green synthetic fuels primarily for fuel cells. The feasibility of the selected concepts is assessed trough a techno-economical calculation, which includes mass and energy balances and economics including CAPEX and OPEX assessments. It is envisioned by the project partners that a production of green synthetic fuels, such as methanol, can 1) bring stability to a future electricity grid with a high share of renewable energy, 2) replace fossil fuels in the transport sector, and 3) boost Danish green technology export. In the project, two technology concepts were derived through carefully considerations and plenum discussions by the project group members: Concept 1): Methanol/DME Synthesis based on Electrolysis assisted Gasification of Wood. Concept 2): Methanol/DME synthesis based on biogas temporarily stored in the natural gas network. Concept 1) is clearly the most favored by the project group and is therefore analyzed for its techno-economic feasibility. Using mass and energy balances the technical perspectives of the concept were investigated, along with an economic breakdown of the CAPEX and OPEX cost of the methanol production plant. The plant was technically compared to a traditional methanol production plant using gasified biomass. The project group has decided to focus on large scale plants, as the scale economics favor large scale plants. Therefore, the dimensioning input of the concept 1) plant is 1000 tons wood per day. This is truly a large scale gasification plant; however, in a methanol synthesis context the plant is not particularly large. The SOEC electrolyzer unit is dimensioned by the need of hydrogen to balance the stoichiometric ratio of the methanol synthesis reaction, which will result in 141 MW installed SOEC. The resulting methanol output is 1,050 tons methanol per day. In comparison to a traditional methanol synthesis plant

  15. Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580 000 subjects within the Me-Can project

    International Nuclear Information System (INIS)

    Lindkvist, Björn; Nagel, Gabriele; Jonsson, Håkan; Selmer, Randi; Ulmer, Hanno; Tretli, Steinar; Stattin, Pär; Manjer, Jonas; Johansen, Dorthe; Stocks, Tanja; Concin, Hans; Bjørge, Tone; Almquist, Martin; Häggström, Christel; Engeland, Anders; Hallmans, Göran

    2014-01-01

    Obesity is associated with an increased risk of esophageal adenocarcinoma (EAC) and a decreased risk of esophageal squamous cell carcinoma (ESCC). However, little is known about the risk of EAC and ESCC related to other metabolic risk factors. We aimed to examine the risk of EAC and ESCC in relation to metabolic risk factors, separately and combined in a prospective cohort study. The Metabolic Syndrome and Cancer cohort includes prospective cohorts in Austria, Norway and Sweden, with blood pressure, lipids, glucose and BMI available from 578 700 individuals. Relative risk (RR) for EAC and ESCC was calculated using Cox’s proportional hazards analysis for metabolic risk factors categorized into quintiles and transformed into z-scores. The standardized sum of all z-scores was used as a composite score for the metabolic syndrome (MetS). In total, 324 histologically verified cases of esophageal cancer were identified (114 EAC, 184 ESCC and 26 with other histology). BMI was associated with an increased risk of EAC (RR 7.34 (95% confidence interval, 2.88-18.7) top versus bottom quintile) and negatively associated with the risk of ESCC (RR 0.38 (0.23-0.62)). The mean value of systolic and diastolic blood pressure (mid blood pressure) was associated with the risk of ESCC (RR 1.77 (1.37-2.29)). The composite MetS score was associated with the risk of EAC (RR 1.56 (1.19-2.05) per one unit increase of z-score) but not ESCC. In accordance with previous studies, high BMI was associated with an increased risk of EAC and a decreased risk of ESCC. An association between high blood pressure and risk of ESCC was observed but alcohol consumption is a potential confounding factor that we were not able to adjust for in the analysis. The MetS was associated with EAC but not ESCC. However this association was largely driven by the strong association between BMI and EAC. We hypothesize that this association is more likely to be explained by factors directly related to obesity than the

  16. Managing projects using a project management approach

    Directory of Open Access Journals (Sweden)

    Marko D. Andrejić

    2011-04-01

    Full Text Available Modern management theory treats all complex tasks and duties like projects and make these projects possible to be managed by a particular organizational-management concept in order to achieve a goal effectively. A large number of jobs and tasks performed in the system of defense or for defense purposes have the characteristics of projects. Project management is both a skill and a science of monitoring human, material, financial, energy and other resources to achieve required objectives within the given limits: deadlines, time, budget, possibility of realization and the satisfaction of the interests of all project participants. Project management is a traditional area of applied (or functional management focused on managing complex and uncertain situations with defined goals. Introduction In conditions of rapid change and high uncertainty, only adaptive organizations survive, i. e. those that are able not only to react quickly to changes but also to proactively take advantage of changes. Development of project management The biggest influence on the development of the area had complex jobs within the engineering profession. In parallel with the traditional approach new approaches began to develop, while the traditional one still remained in use. Contrary to the traditional engineering approach, a dynamic model first developed in order to respond to demands for greater control of costs. Project management Project management is a skill and knowledge of human and material resources to achieve set objectives within prescribed limits: deadlines, time, budget, possibility of realization, and the satisfaction of all participants in the project. In order to realize a project effectively, it is necessary to manage it rationally. Planning and project management A project plan is a document that allows all team members insight on where to go, when to start and when to arrive, what is necessary to be done in order to achieve the project objectives and what

  17. Storytelling in Projects

    DEFF Research Database (Denmark)

    Munk-Madsen, Andreas; Andersen, Peter Bøgh

    2006-01-01

    project managers should not only be concerned with project plans, but also with project stories. In this paper we explore some basic principles for transforming project plans into appealing stories. We discuss what may happen to stories once they are released into public space. And we illustrate how......Plans and stories are two different ways of communicating about projects. Project plans are formalized descriptions, primarily supporting coordination. Project stories are accounts whose primary function is emotional appeal. Project stories influence the projects’ chances of success. Therefore...... the possibilities of telling favorable stories may have repercussions on the project planning....

  18. The Ethiopian Flora Project

    DEFF Research Database (Denmark)

    Demissew, Sebsebe; Brochmann, Christian; Kelbessa, Ensermu

    2011-01-01

    The account reviews and analyses the scietific projects derived from activities in connection with the Ethiopian Flora Project, including the [Ethiopian] Monocot Project, the Afro-alpine "Sky-island" project, the Vegetation and Ecological Conditions of Plantations Project, the Fire Ecology Projec...

  19. Capital projects coordination

    Directory of Open Access Journals (Sweden)

    Zubović Jovan

    2004-01-01

    Full Text Available This paper looks at the difficulties of managing modem capital projects and endeavors to reduce the complexities to simpler and more understandable terms. It examines the project environment, defines project management and discusses points of difference from traditional management. In the second part of the paper are presented fundamentals for project success for different types of projects.

  20. From project management to project leadership

    NARCIS (Netherlands)

    Braun, F.; Avital, M.

    2010-01-01

    It is virtually a truism that good leadership practices can help project managers with attaining the desired project outcome. However, a better understanding of which leadership practices enable project managers to be more effective warrants further investigation. Subsequently, in this study, we

  1. An IS Project Management Course Project

    Science.gov (United States)

    Frank, Ronald L.

    2010-01-01

    Information Systems curricula should provide project management (PM) theory, current practice, and hands-on experience. The schedule usually does not allow time in Analysis and Design courses for development oriented project management instruction other than a short introduction. Similarly, networking courses usually don't put project management…

  2. Managing Projects for Change: Contextualised Project Management

    Science.gov (United States)

    Tynan, Belinda; Adlington, Rachael; Stewart, Cherry; Vale, Deborah; Sims, Rod; Shanahan, Peter

    2010-01-01

    This paper will detail three projects which focussed on enhancing online learning at a large Australian distance education University within a School of Business, School of Health and School of Education. Each project had special funding and took quite distinctive project management approaches, which reflect the desire to embed innovation and…

  3. Tuft (caveolated) cells in two human colon carcinoma cell lines.

    OpenAIRE

    Barkla, D. H.; Whitehead, R. H.; Foster, H.; Tutton, P. J.

    1988-01-01

    The presence of an unusual cell type in two human colon carcinoma cell lines is reported. The cells show the same morphology as "tuft" (caveolated) cells present in normal gastrointestinal epithelium. Tuft cells were seen in cell line LIM 1863 growing in vitro and in human colon carcinoma cell line LIM 2210 growing as subcutaneous solid tumour xenografts in nude mice. Characteristic morphologic features of tuft cells included a wide base, narrow apex and a tuft of long microvilli projecting f...

  4. Efficient Regular Perovskite Solar Cells Based on Pristine [70]Fullerene as Electron-Selective Contact.

    Science.gov (United States)

    Collavini, Silvia; Kosta, Ivet; Völker, Sebastian F; Cabanero, German; Grande, Hans J; Tena-Zaera, Ramón; Delgado, Juan Luis

    2016-06-08

    [70]Fullerene is presented as an efficient alternative electron-selective contact (ESC) for regular-architecture perovskite solar cells (PSCs). A smart and simple, well-described solution processing protocol for the preparation of [70]- and [60]fullerene-based solar cells, namely the fullerene saturation approach (FSA), allowed us to obtain similar power conversion efficiencies for both fullerene materials (i.e., 10.4 and 11.4 % for [70]- and [60]fullerene-based devices, respectively). Importantly, despite the low electron mobility and significant visible-light absorption of [70]fullerene, the presented protocol allows the employment of [70]fullerene as an efficient ESC. The [70]fullerene film thickness and its solubility in the perovskite processing solutions are crucial parameters, which can be controlled by the use of this simple solution processing protocol. The damage to the [70]fullerene film through dissolution during the perovskite deposition is avoided through the saturation of the perovskite processing solution with [70]fullerene. Additionally, this fullerene-saturation strategy improves the performance of the perovskite film significantly and enhances the power conversion efficiency of solar cells based on different ESCs (i.e., [60]fullerene, [70]fullerene, and TiO2 ). Therefore, this universal solution processing protocol widens the opportunities for the further development of PSCs. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Cytotoxic effect of x-irradiation of mouse tumor cells in the presence of Korean ginseng extract

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Hyoung Cheol; Kim, Jin Ki; Kim, Jung Soo [College of Medicine, Chonbuk National Univ., Junju (Korea, Republic of); Choi, Dong Seong [College of Medicine, Woosuck Univ., Wanju (Korea, Republic of)

    2000-09-01

    We already reported the results that aqueous extract of Korean ginseng roots showed a marked cytotoxicity. In this study, we investigated whether combined ginseng product with X-irradiation increase the cytotoxicity of tumor cells than X-irradiation or not. Fifty gram of Korean ginseng powder mixed with 1 L of distilled water was extracted with reflux flask under condition of 100 .deg. C for 5 hrs. This aqueous ginseng extract was filtered, centrifuged and then was freezed under condition of -90 .deg. C for 16-18 hrs. The freezing extract was dried with freeze drier, and then diluted. X-irradiation was given to tumor cells by 6 MeV linear accelerator. The cytotoxicity of ginseng in vitro was evaluated from its ability to reduce the clonogenecity of fibrosarcoma (FSa ll) cells. In X-irradiation alone group, each 2, 4, 6 and 8 Gy was given to tumor cells. In X-irradiation with ginseng group, 0.2 mg/mL or ginseng extract was exposed to tumor cells for 1 hour before X-irradiation. The yield for 50 g of ginseng extract which was treated with freezing drier was 3.13 g(6.3%). Cytotoxicity in vitro was measured as survival fraction which was judged from the curve, at ginseng concentration of 0.001, 0.01, 0.1 and 1 mg/ml were 0.89{+-}0.04, 0.86{+-}0.06, 0.73{+-}0.01 and 0.09{+-}0.02, respectively. Survival fraction at X-irradiation alone of 2, 4, 6 and 8 Gy were 0.81{+-}0.07, 0.42{+-}0.08, 0.15{+-}0.02, 0.03{+-}0.01, respectively. But, survival fraction in combined group of X-irradiation and ginseng (0.2mg/mL) at each same radiation dose were 0.28{+-}0.01, 0.18{+-}0.03, 0.08{+-}0.02, 0.006{+-}0.002, respectively (p<0.05). The yield for ginseng extract which was treated with freezing drier was 6.3%. Cytotoxicity of Fsa II in combined ginseng with X-irradiation group was increased than that at X-irradiation alone group, and its enhancing effect seemed to be added.

  6. Cytotoxic effect of x-irradiation of mouse tumor cells in the presence of Korean ginseng extract

    International Nuclear Information System (INIS)

    Kwon, Hyoung Cheol; Kim, Jin Ki; Kim, Jung Soo; Choi, Dong Seong

    2000-01-01

    We already reported the results that aqueous extract of Korean ginseng roots showed a marked cytotoxicity. In this study, we investigated whether combined ginseng product with X-irradiation increase the cytotoxicity of tumor cells than X-irradiation or not. Fifty gram of Korean ginseng powder mixed with 1 L of distilled water was extracted with reflux flask under condition of 100 .deg. C for 5 hrs. This aqueous ginseng extract was filtered, centrifuged and then was freezed under condition of -90 .deg. C for 16-18 hrs. The freezing extract was dried with freeze drier, and then diluted. X-irradiation was given to tumor cells by 6 MeV linear accelerator. The cytotoxicity of ginseng in vitro was evaluated from its ability to reduce the clonogenecity of fibrosarcoma (FSa ll) cells. In X-irradiation alone group, each 2, 4, 6 and 8 Gy was given to tumor cells. In X-irradiation with ginseng group, 0.2 mg/mL or ginseng extract was exposed to tumor cells for 1 hour before X-irradiation. The yield for 50 g of ginseng extract which was treated with freezing drier was 3.13 g(6.3%). Cytotoxicity in vitro was measured as survival fraction which was judged from the curve, at ginseng concentration of 0.001, 0.01, 0.1 and 1 mg/ml were 0.89±0.04, 0.86±0.06, 0.73±0.01 and 0.09±0.02, respectively. Survival fraction at X-irradiation alone of 2, 4, 6 and 8 Gy were 0.81±0.07, 0.42±0.08, 0.15±0.02, 0.03±0.01, respectively. But, survival fraction in combined group of X-irradiation and ginseng (0.2mg/mL) at each same radiation dose were 0.28±0.01, 0.18±0.03, 0.08±0.02, 0.006±0.002, respectively (p<0.05). The yield for ginseng extract which was treated with freezing drier was 6.3%. Cytotoxicity of Fsa II in combined ginseng with X-irradiation group was increased than that at X-irradiation alone group, and its enhancing effect seemed to be added

  7. I-15 North Project

    Science.gov (United States)

    2013-11-05

    Goals of this project were as follows: (1) Conduct a comprehensive evaluation study on Nevada's I-15 North Design Build Project; (2) Analyze project implementation with respect to construction zone rules by which the contractor had to abide; (3) Anal...

  8. Web Project Management

    OpenAIRE

    Suralkar, Sunita; Joshi, Nilambari; Meshram, B B

    2013-01-01

    This paper describes about the need for Web project management, fundamentals of project management for web projects: what it is, why projects go wrong, and what's different about web projects. We also discuss Cost Estimation Techniques based on Size Metrics. Though Web project development is similar to traditional software development applications, the special characteristics of Web Application development requires adaption of many software engineering approaches or even development of comple...

  9. The 4D Nucleome Project

    Science.gov (United States)

    Dekker, Job; Belmont, Andrew S.; Guttman, Mitchell; Leshyk, Victor O.; Lis, John T.; Lomvardas, Stavros; Mirny, Leonid A.; O’Shea, Clodagh C.; Park, Peter J.; Ren, Bing; Ritland Politz, Joan C.; Shendure, Jay; Zhong, Sheng

    2017-01-01

    Preface The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic understanding of how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental approaches will be combined with biophysical modeling to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells. PMID:28905911

  10. USAID Anticorruption Projects Database

    Data.gov (United States)

    US Agency for International Development — The Anticorruption Projects Database (Database) includes information about USAID projects with anticorruption interventions implemented worldwide between 2007 and...

  11. Project 2010 Bible

    CERN Document Server

    Marmel, Elaine

    2010-01-01

    A comprehensive reference on the latest version of the leading enterprise project management software: Microsoft Project 2010. Microsoft Project allows users to manage business activities effectively by sharing project information, performing modeling and scenario analyses, standardizizing reporting processes, and more. This soup-to-nuts reference covers both the professional and standard versions of the latest iteration of Microsoft Project, as well as Project Server, so that you can efficiently manage your business projects. Veteran author Elaine Marmel begins with an overview of project man

  12. Project 2010 For Dummies

    CERN Document Server

    Muir, Nancy C

    2010-01-01

    A friendly reference guide to Microsoft Project, the leading enterprise project management software. As project management software, Microsoft Project allows you to oversee your business activities effectively. You can manage resources, share project info, perform modeling and scenario analysis, and standardize reporting processes. This easy-to-understand guide is completely updated to cover the latest changes and newest enhancements to Project 2010 and shows you how to get Project 2010 to work for you. After an introduction to basic project management concepts, you'll discover the mechanics o

  13. Performance of NCAP projection displays

    Science.gov (United States)

    Jones, Philip J.; Tomita, Akira; Wartenberg, Mark

    1991-08-01

    Prototypes of projection displays based on dispersions of liquid crystal in polymer matrices are beginning to appear. The principle of operation depends on electrically switchable light scattering. They are potentially much brighter than current cathode ray tube (CRT) or twisted nematic liquid crystal (TN LC) cell based displays. Comparisons of efficacy and efficiency show this. The contrast and brightness of such displays depend on a combination of the f- number of the projection system and the scattering characteristics of the light valve. Simplified equations can be derived to show these effects. The degree of scattering of current NCAP formulations is sufficient to produce good contrast projection displays, at convenient voltages, that are around three times brighter than TN LC projectors because of the lack of polarizers in the former.

  14. Japan's Sunshine Project

    Science.gov (United States)

    1992-07-01

    A summary report is given on the results of hydrogen energy research and development achieved during 1991 under the Sunshine Project. In hydrogen manufacturing, regenerative cells that can also generate power as fuel cells were discussed by using solid macromolecular electrolytic films for the case where no electrolysis is carried out with water electrolysis. Yttria stabilized zirconia (YSZ), an oxide solid electrolyte was used for the basic research on high-temperature steam electrolysis. Compositions of hydrogen storage alloys and their deterioration mechanisms were investigated to develop hydrogen transportation and storage technologies. High-density hydrides were searched, and fluidization due to paraffin was discussed. Electrode materials and forming technologies were discussed to develop a hydrogen to power conversion system using hydrogen storage alloys as reversible electrodes. Hydrogen-oxygen combustion was studied in terms of reactive theories, and so was the control of ignition and combustion using ultraviolet ray ignition plasma. Studies were made on hydrogen brittlement in welds on materials in hydrogen utilization and its preventive measures. Surveys were given on technical movements and development problems in high-efficiency, pollution-free hydrogen combustion turbines.

  15. Computer applications in project KARP

    International Nuclear Information System (INIS)

    Raju, R.P.; Siddiqui, H.R.

    1992-01-01

    For effective project implementation of Kalpakkam Reprocessing Plant (KARP) at Kalpakkam, an elaborate Management Information Systems (MIS) was developed in-house for physical and financial progress monitoring and reporting. Computer aided design software for design of process piping layout was also developed and implemented for generation of process cell piping drawings for construction purposes. Modelling and simulation studies were carried out to optimize process parameters and fault tree analysis techniques utilised for evaluating plant availability factors. (author). 2 tabs

  16. Project development symposium

    Energy Technology Data Exchange (ETDEWEB)

    1983-01-01

    Papers were presented on the following: project evaluation; case studies - minerals; finance; applied finance; legal; manpower/industrial relations; and new technologies. Those papers on the coal industry were: mine planning for coal project development; the planning and management of a lignite exploration contract in Thailand; development of the West Cliff extended project; Ulan: a resource development; Saxonvale mine development a case study in project planning and project management; the role of marketing in the development of a new coal project; technical support for coal marketing; infrastructure development for the Ulan project; underground mine project developments; the bucketwheel excavator at Goonyella - a case study; tax aspects of mining development projects; cost of capital mining development projects; and trends in development project finance. 16 papers were abstracted separately.

  17. Mozambique Cell Phone Savings Project: Endline Survey

    Data.gov (United States)

    US Agency for International Development — Smallholders in rural Mozambique are typically characterized by low agricultural productivity, which is in part caused by very low levels of input usage. In the...

  18. Mozambique Cell Phone Savings Project: Baseline Survey

    Data.gov (United States)

    US Agency for International Development — Smallholders in rural Mozambique are typically characterized by low agricultural productivity, which is in part caused by very low levels of input usage. In the...

  19. PROJECT SCOPE MANAGEMENT PROCESS

    Directory of Open Access Journals (Sweden)

    Yana Derenskaya

    2018-01-01

    Full Text Available The purpose of the article is to define the essence of project scope management process, its components, as well as to develop an algorithm of project scope management in terms of pharmaceutical production. Methodology. To carry out the study, available information sources on standards of project management in whole and elements of project scope management in particular are analysed. Methods of system and structural analysis, logical generalization are used to study the totality of subprocesses of project scope management, input and output documents, and to provide each of them. Methods of network planning are used to construct a precedence diagram of project scope management process. Results of the research showed that components of the project scope management are managing the scope of the project product and managing the content of project work. It is the second component is investigated in the presented work as a subject of research. Accordingly, it is defined that project scope management process is to substantiate and bring to the realization the necessary amount of work that ensures the successful implementation of the project (achievement of its goal and objectives of individual project participants. It is also determined that the process of managing the project scope takes into account the planning, definition of the project scope, creation of the structure of project work, confirmation of the scope and management of the project scope. Participants of these subprocesses are: customer, investor, and other project participants – external organizations (contractors of the project; project review committee; project manager and project team. It is revealed that the key element of planning the project scope is the formation of the structure of design work, the justification of the number of works, and the sequence of their implementation. It is recommended to use the following sequence of stages for creating the structure of project work

  20. Introduction to the Project

    DEFF Research Database (Denmark)

    Kuhn, Johan M.; Malchow-Møller, Nikolaj; Sørensen, Anders

    In this note a short introduction to the project “Employment Effects of Entrepreneurs” is presented. First, we describe the purpose of the project; second, we present the background; third, we briefly describe the three papers that constitute the output of the project, and fourth, we discuss two...... important qualifications for the understanding of the contributions and results established in the project....

  1. The virtual GULLIVER project

    NARCIS (Netherlands)

    Trappl, R.; Nijholt, Antinus; Stuk, M.; Zwiers, Jakob

    2002-01-01

    In this paper we discuss our virtual reality project Gulliver. This project is part of a more comprehensive project conceived by two artists, Matjaž Štuk and Alena Hudcovicová, called “Gulliver’s Museum of Living Art��?. Our part of the project involves a virtual reality version of Swift’s Gulliver

  2. Innovations in project activities

    Directory of Open Access Journals (Sweden)

    Serbskaya O.V.

    2016-11-01

    Full Text Available this article considers the ways of project management, models of project management: classical model and the model of flexible designing Agile, pays more attention to the process of project management using Agile model and to the problems of using the project management models in modern conditions.

  3. The 100 People Project

    Science.gov (United States)

    McLeod, Keri

    2007-01-01

    This article describes the 100 People Project and how the author integrates the project in her class. The 100 People Project is a nonprofit organization based in New York City. The organization poses the question: If there were only 100 people in the world, what would the world look like? Through the project, students were taught about ethics in…

  4. Earth System Science Project

    Science.gov (United States)

    Rutherford, Sandra; Coffman, Margaret

    2004-01-01

    For several decades, science teachers have used bottles for classroom projects designed to teach students about biology. Bottle projects do not have to just focus on biology, however. These projects can also be used to engage students in Earth science topics. This article describes the Earth System Science Project, which was adapted and developed…

  5. Projects as value constellations

    DEFF Research Database (Denmark)

    Laursen, Markus

    Creating value has been outlined as very central to projects applying the organizational perspective to projects. It has been suggested that value is created in value constellations or project networks, where actors work together to create value. However, research on the value creation process...... in value constellations is scarce, and through an exploratory study of two project networks in a cultural setting we investigate how value is created in value constellations. We outline how each project may be a distinct type of value constellation, one project creates value for the partners of the network...... as a consortium, and the project creates value primarily for others as a facilitator....

  6. Project stakeholder management

    CERN Document Server

    Eskerod, Pernille

    2013-01-01

    Carrying out a project as planned is not a guarantee for success. Projects may fail because project management does not take the requirements, wishes and concerns of stakeholders sufficiently into account. Projects can only be successful though contributions from stakeholders. And in the end, it is the stakeholders that evaluate whether they find that the project is a success. To manage stakeholders effectively, you need to know your stakeholders, their behaviours and attitudes towards the project. In Project Stakeholder Management, the authors give guidance on how to adopt an analytical and s

  7. Modern project-management

    CERN Multimedia

    CERN. Geneva

    2003-01-01

    This lecture will focus on the following issues: - The current state of the art in Project Management, especially the integration of Project Management with general management activities, and the integrated view of resources allocation. - Overview of the project life cycle, the phases and the deliverables - Necessity and limits of planning in a research environment - Organizational aspects of the projects the roles of the stakeholders - How to get the resources when they are needed - Risk Management in Projects - Earned value - How to keep a project on track (schedule and budget) - Management of the suppliers - Closing of the project

  8. Introduction to the Project

    DEFF Research Database (Denmark)

    Kuhn, Johan M.; Malchow-Møller, Nikolaj; Sørensen, Anders

    In this note a short introduction to the project “Employment Effects of Entrepreneurs” is presented. First, we describe the purpose of the project; second, we present the background; third, we briefly describe the three papers that constitute the output of the project, and fourth, we discuss two ...... important qualifications for the understanding of the contributions and results established in the project.......In this note a short introduction to the project “Employment Effects of Entrepreneurs” is presented. First, we describe the purpose of the project; second, we present the background; third, we briefly describe the three papers that constitute the output of the project, and fourth, we discuss two...

  9. Choice of large projects

    Energy Technology Data Exchange (ETDEWEB)

    Harris, R

    1978-08-01

    Conventional cost/benefit or project analysis has generally not taken into account circumstances in which the project under consideration is large enough that its introduction to the economy would have significant general equilibrium effects. In this paper, rules are examined that would indicate whether such large projects should be accepted or rejected. The rules utilize information yielded by before-project and after-project equilibrium prices and production data. Rules are developed for the undistorted ''first-best'' case, the case in which the fixed costs of the project are covered by distortionary taxation, and for the case of projects producing public goods. 34 references.

  10. Project Half Double

    DEFF Research Database (Denmark)

    Svejvig, Per; Gerstrøm, Anna; Frederiksen, Signe Hedeboe

    The Half Double mission: Project Half Double has a clear mission. We want to succeed in finding a project methodology that can increase the success rate of our projects while increasing the development speed of new products and services. We are convinced that by doing so we can strengthen...... the competitiveness of Denmark and play an important role in the battle for jobs and future welfare. The overall goal is to deliver “Projects in half the time with double the impact” where projects in half the time should be understood as half the time to impact (benefit realization, effect is achieved......) and not as half the time for project execution. The Half Double project journey: It all began in May 2013 when we asked ourselves: How do we create a new and radical project paradigm that can create successful projects? Today we are a movement of hundreds of passionate project people, and it grows larger...

  11. Project Finance: Basic Components

    OpenAIRE

    Alfieri Li Ojeda, Jaime

    2015-01-01

    The natural speed of the contemporary world demands large investment projects which require specialized financial techniques such as Project Finance, defined as a fund to finance investment projects of great magnitude. Every Project Finance involves a wide range of elements such as promoters, government, contractors andsuppliers, among others, that will ensure project success. La rapidez del mundo contemporáneo exige que los grandes proyectos de inversión requieran de técnicas financieras ...

  12. Project delivery system (PDS)

    CERN Document Server

    2001-01-01

    As business environments become increasingly competitive, companies seek more comprehensive solutions to the delivery of their projects. "Project Delivery System: Fourth Edition" describes the process-driven project delivery systems which incorporates the best practices from Total Quality and is aligned with the Project Management Institute and ISO Quality Standards is the means by which projects are consistently and efficiently planned, executed and completed to the satisfaction of clients and customers.

  13. IT Project Management Metrics

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available Many software and IT projects fail in completing theirs objectives because different causes of which the management of the projects has a high weight. In order to have successfully projects, lessons learned have to be used, historical data to be collected and metrics and indicators have to be computed and used to compare them with past projects and avoid failure to happen. This paper presents some metrics that can be used for the IT project management.

  14. Methodologies of Project Management

    Directory of Open Access Journals (Sweden)

    Wojciech Macek

    2011-07-01

    Full Text Available This paper presents comparison of three most popular project management standardsbelonging to a wider group of models (for example, PMBOK, Prince 2, CMMI, ISO 10006,BS 6079, IPMA Competence Baseline, European Commission Project Cycle ManagementGuidelines. The author discusses methods of project management according to PMBoK,Prince 2 and ISO 10006, some chosen criteria and fields of knowledge, such as generalregulations of standards, project range management, resources management, and processesconnected with risk, systems of project quality management.

  15. Comparison of primary tumour volumes delineated on four-dimensional computed tomography maximum intensity projection and 18F-fluorodeoxyglucose positron emission tomography computed tomography images of non-small cell lung cancer

    International Nuclear Information System (INIS)

    Duan, Yili; Li, Jianbin; Zhang, Yingjie; Wang, Wei; Fan, Tingyong; Shao, Qian; Xu, Min; Guo, Yanluan; Sun, Xiaorong; Shang, Dongping

    2015-01-01

    The study aims to compare the positional and volumetric differences of tumour volumes based on the maximum intensity projection (MIP) of four-dimensional CT (4DCT) and 18 F-fluorodexyglucose ( 18 F-FDG) positron emission tomography CT (PET/CT) images for the primary tumour of non-small cell lung cancer (NSCLC). Ten patients with NSCLC underwent 4DCT and 18 F-FDG PET/CT scans of the thorax on the same day. Internal gross target volumes (IGTVs) of the primary tumours were contoured on the MIP images of 4DCT to generate IGTV MIP . Gross target volumes (GTVs) based on PET (GTV PET ) were determined with nine different threshold methods using the auto-contouring function. The differences in the volume, position, matching index (MI) and degree of inclusion (DI) of the GTV PET and IGTV MIP were investigated. In volume terms, GTV PET2.0 and GTV PET20% approximated closely to IGTV MIP with mean volume ratio of 0.93 ± 0.45 and 1.06 ± 0.43, respectively. The best MI was between IGTV MIP and GTV PET20% (0.45 ± 0.23). The best DI of IGTV MIP in GTV PET was IGTV MIP in GTV PET20% (0.61 ± 0.26). In 3D PET images, the GTVPET contoured by standardised uptake value (SUV) 2.0 or 20% of maximal SUV (SUV max ) approximate closely to the IGTV MIP in target size, while the spatial mismatch is apparent between them. Therefore, neither of them could replace IGTV MIP in spatial position and form. The advent of 4D PET/CT may improve the accuracy of contouring the perimeter for moving targets.

  16. Project Half Double

    DEFF Research Database (Denmark)

    Svejvig, Per; Ehlers, Michael; Adland, Karoline Thorp

    activities carried out within the framework of the projects. The formal part of Project Half Double was initiated in June 2015. We started out by developing, refining and testing the Half Double methodology on seven pilot projects in the first phase of the project, which will end June 2016. The current......Project Half Double has a clear mission to succeed in finding a project methodology that can increase the success rate of our projects while increasing the speed at which we generate new ideas and develop new products and services. Chaos and complexity should be seen as a basic condition...... and as an opportunity rather than a threat and a risk. We are convinced that by doing so, we can strengthen Denmark’s competitiveness and play an important role in the battle for jobs and future welfare. The overall goal is to deliver “projects in half the time with double the impact”, where projects in half the time...

  17. Mammalian cell biology

    International Nuclear Information System (INIS)

    Elkind, M.M.

    1975-01-01

    Progress is reported on the following research projects: the effects of N-ethyl-maleimide and hydroxyurea on hamster cells in culture; sensitization of synchronized human cells to x rays by N-ethylmaleimide; sensitization of hypoxic mammalian cells with a sulfhydryl inhibitor; damage interaction due to ionizing and nonionizing radiation in mammalian cells; DNA damage relative to radioinduced cell killing; spurious photolability of DNA labeled with methyl- 14 C-thymidine; radioinduced malignant transformation of cultured mouse cells; a comparison of properties of uv and near uv light relative to cell function and DNA damage; Monte Carlo simulation of DNA damage and repair mechanisms; and radiobiology of fast neutrons

  18. Project management case studies

    CERN Document Server

    Kerzner, Harold R

    2013-01-01

    A new edition of the most popular book of project management case studies, expanded to include more than 100 cases plus a ""super case"" on the Iridium Project Case studies are an important part of project management education and training. This Fourth Edition of Harold Kerzner''s Project Management Case Studies features a number of new cases covering value measurement in project management. Also included is the well-received ""super case,"" which covers all aspects of project management and may be used as a capstone for a course. This new edition:Contains 100-plus case studies drawn from re

  19. The USE Project

    DEFF Research Database (Denmark)

    Frøkjær, E.; Hornbæk, K.; Høegh, Rune Thaarup

    2006-01-01

    This paper provides experience from activities in the USE project. The USE project is a research project that aims at bridging the gap between usability evaluation and user interface design. It is conducted from 2005 to 2008 in collaboration between researchers from Aalborg University and Copenha......This paper provides experience from activities in the USE project. The USE project is a research project that aims at bridging the gap between usability evaluation and user interface design. It is conducted from 2005 to 2008 in collaboration between researchers from Aalborg University...... and Copenhagen University, and developers and managers working in software development organizations....

  20. IT Project Selection

    DEFF Research Database (Denmark)

    Pedersen, Keld

    2016-01-01

    for initiation. Most of the research on project selection is normative, suggesting new methods, but available empirical studies indicate that many methods are seldom used in practice. This paper addresses the issue by providing increased understanding of IT project selection practice, thereby facilitating...... the development of methods that better fit current practice. The study is based on naturalistic decision-making theory and interviews with experienced project portfolio managers who, when selecting projects, primarily rely on political skills, experience and personal networks rather than on formal IT project......-selection methods, and these findings point to new areas for developing new methodological support for IT project selection....

  1. Fuel cells

    International Nuclear Information System (INIS)

    Niederdoeckl, J.

    2001-01-01

    Europe has at present big hopes on the fuel cells technology, in comparison with other energy conversion technologies, this technology has important advantages, for example: high efficiency, very low pollution and parallel use of electric and thermal energy. Preliminary works for fuel cells developing and its commercial exploitation are at full speed; until now the European Union has invested approx. 1.7 billion Schillings, 60 relevant projects are being executed. The Austrian industry is interested in applying this technique to drives, thermal power stations and the miniature fuel cells as replacement of batteries in electronic products (Notebooks, mobile telephones, etc.). A general description of the historic development of fuel cells including the main types is given as well as what is the situation in Austria. (nevyjel)

  2. 17th Symposium of NEDO projects. Introducing/spreading project subcommittee; Donyu fukyu jigyo bunkakai. Dai 17kai jigyo hokokukai

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    The results of the following themes are presented in this subcommittee; (1) outline of the new energy introduction promotion department, (2) the project results, and (3) introduction of the examples. For the theme (1), NEDO is supporting the projects for introducing and promoting new energy systems, feasibility studies for introduction of these systems, and field test (FT) projects to accumulate the experiences, e.g., collecting the data by operating these systems under actual loads, development and technology demonstration projects for introduction of new energy systems, and advisory projects for supporting introduction of new energy systems. For the theme (2), those results reported include the results and examples of the FT projects for power generation by photovoltaic cells and wind power generation, results of the FT project for power generation by fuel cells and creation of the FT projects for pioneer high-efficiency energy systems, current status of the environment-friendly energy community projects (heat supply systems), results and examples of the environment- friendly energy community projects (power generation projects), demonstration tests for establishing the distributed power supply systems of the next generation, tests for establishing techniques for, e.g., load-leveling in power generation by photovoltaic cells for residential purposes, results of the project for technology of utilizing unutilized energy, survey on the techniques for power generation by wastes, and advisory projects for supporting introduction of new energy. (NEDO)

  3. Chinese Manned Space Utility Project

    Science.gov (United States)

    Gu, Y.

    Since 1992 China has been carrying out a conspicuous manned space mission A utility project has been defined and created during the same period The Utility Project of the Chinese Manned Space Mission involves wide science areas such as earth observation life science micro-gravity fluid physics and material science astronomy space environment etc In the earth observation area it is focused on the changes of global environments and relevant exploration technologies A Middle Revolution Image Spectrometer and a Multi-model Micro-wave Remote Sensor have been developed The detectors for cirrostratus distribution solar constant earth emission budget earth-atmosphere ultra-violet spectrum and flux have been manufactured and tested All of above equipment was engaged in orbital experiments on-board the Shenzhou series spacecrafts Space life science biotechnologies and micro-gravity science were much concerned with the project A series of experiments has been made both in ground laboratories and spacecraft capsules The environmental effect in different biological bodies in space protein crystallization electrical cell-fusion animal cells cultural research on separation by using free-low electrophoresis a liquid drop Marangoni migration experiment under micro-gravity as well as a set of crystal growth and metal processing was successfully operated in space The Gamma-ray burst and high-energy emission from solar flares have been explored A set of particle detectors and a mass spectrometer measured

  4. One project's waste is another project's resource

    International Nuclear Information System (INIS)

    Short, J.

    1997-01-01

    The author describes the efforts being made toward pollution prevention within the DOE complex, as a way to reduce overall project costs, in addition to decreasing the amount of waste to be handled. Pollution prevention is a concept which is trying to be ingrained into project planning. Part of the program involves the concept that ultimately the responsibility for waste comes back to the generator. Parts of the program involve efforts to reuse materials and equipment on new projects, to recycle wastes to generate offsetting revenue, and to increase awareness, accountability and incentives so as to stimulate action on this plan. Summaries of examples are presented in tables

  5. Integrated project support environments the ASPECT project

    CERN Document Server

    Brown, Alan W

    1991-01-01

    A major part of software engineering developments involve the use of computing tools which facilitate the management, maintenance, security, and building of long-scale software engineer projects. Consequently, there have been a proliferation of CASE tools and IPSES. This book looks at IPSES in general and the ASPECT project in particular, providing design and implementation details, as well as locating ASPECT in IPSE developments.Survey of integrated project support environments for more efficient software engineering**Description of a large scale IPSE--ASPECT**Evaluation of formal methods in

  6. Savannah River bus project

    Energy Technology Data Exchange (ETDEWEB)

    Summers, W.A. [Westinghouse Savannah River Co., Aiken, SC (United States)

    1998-08-01

    The H2Fuel Bus is the world`s first hybrid hydrogen electric transit bus. It was developed through a public/private partnership involving several leading technology and industrial organizations in the Southeast, with primary funding and program management provided by the Department of Energy. The primary goals of the project are to gain valuable information on the technical readiness and economic viability of hydrogen buses and to enhance the public awareness and acceptance of emerging hydrogen technologies. The bus has been operated by the transit agency in Augusta, Georgia since April, 1997. It employs a hybrid IC engine/battery/electric drive system, with onboard hydrogen fuel storage based on the use of metal hydrides. Initial operating results have demonstrated an overall energy efficiency (miles per Btu) of twice that of a similar diesel-fueled bus and an operating range twice that of an all-battery powered electric bus. Tailpipe emissions are negligible, with NOx less than 0.2 ppm. Permitting, liability and insurance issues were addressed on the basis of extensive risk assessment and safety analyses, with the inherent safety characteristic of metal hydride storage playing a major role in minimizing these concerns. Future plans for the bus include continued transit operation and use as a national testbed, with potential modifications to demonstrate other hydrogen technologies, including fuel cells.

  7. Cesium legacy safety project management work plan

    International Nuclear Information System (INIS)

    Durham, J.S.

    1998-01-01

    This Management Work Plan (MWP) describes the process flow, quality assurance controls, and the Environment, Safety, and Health requirements of the Cesium Legacy Safety Project. This MWP provides an overview of the project goals and methods for repackaging the non-conforming Type W overpacks and packaging the CsCl powder and pellets. This MWP is not intended to apply to other activities associated with the CsCl Legacy Safety Program (i.e., clean out of South Cell)

  8. MANAGING MULTICULTURAL PROJECT TEAMS

    Directory of Open Access Journals (Sweden)

    Cezar SCARLAT

    2014-06-01

    Full Text Available The article is based on literature review and authors’ own recent experience in managing multicultural project teams, in international environment. This comparative study considers two groups of projects: technical assistance (TA projects versus information technology (IT projects. The aim is to explore the size and structure of the project teams – according to the team formation and its lifecycle, and to identify some distinctive attributes of the project teams – both similarities and differences between the above mentioned types of projects. Distinct focus of the research is on the multiculturalism of the project teams: how the cultural background of the team members influences the team performance and team management. Besides the results of the study are the managerial implications: how the team managers could soften the cultural clash, and avoid inter-cultural misunderstandings and even conflicts – in order to get a better performance. Some practical examples are provided as well.

  9. Construction project management handbook.

    Science.gov (United States)

    2012-03-01

    The purpose of the FTA Construction Project Management Handbook is to provide guidelines for use by public transit agencies (Agen-cies) undertaking substantial construction projects, either for the first time or with little prior experience with cons...

  10. BioProject

    Data.gov (United States)

    U.S. Department of Health & Human Services — The BioProject database provides an organizational framework to access information about research projects with links to data that have been or will be deposited...

  11. The Phebus FP project

    International Nuclear Information System (INIS)

    Delchambre, P.; Von der Hardt, P.

    1989-01-01

    This report summarizes the pre-project studies concerning the PHEBUS FP facility. After recalling the programme objectives, it describes the projected modifications to the PHEBUS reactor, outlines new installations and justifies the selected options

  12. Number projection method

    International Nuclear Information System (INIS)

    Kaneko, K.

    1987-01-01

    A relationship between the number projection and the shell model methods is investigated in the case of a single-j shell. We can find a one-to-one correspondence between the number projected and the shell model states

  13. Successful project management

    CERN Document Server

    Young, Trevor L

    2016-01-01

    Successful Project Management, 5th edition, is an essential guide for anyone who wants to improve the success rate of their projects. It will help managers to maintain a balance between the demands of the customer, the project, the team and the organization. Covering the more technical aspects of a project from start to completion it contains practised and tested techniques, covering project conception and start-up, how to manage stake holders, effective risk management, project planning and launch and execution. Also including a brand new glossary of key terms, it provides help with evaluating your project as well as practical checklists and templates to ensure success for any ambitious project manager. With over one million copies sold, the hugely popular Creating Success series covers a wide variety of topic, with the latest editions including new chapters such as Tough Conversations and Treating People Right. This indispensable business skills collection is suited to a variety of roles, from someone look...

  14. Unicycle Project Report

    OpenAIRE

    Thomson, S

    2010-01-01

    The Unicycle project implemented an institutional Open Educational Resource repository with a view to ensuring sustainability in approach by embedding OER as an Assessment, Learning and Teaching strategy. This is the final submitted report for the project.

  15. Collaborative Contracting in Projects

    NARCIS (Netherlands)

    Suprapto, M.

    2016-01-01

    Project practitioners have increasingly recognized the importance of collaborative relationships to ensure successful executions of projects. However, the ability to sustain and consistenly drive real collaborative attitudes and behavior for achieving the desired outcomes remains of enduring

  16. Project Tasks in Robotics

    DEFF Research Database (Denmark)

    Sørensen, Torben; Hansen, Poul Erik

    1998-01-01

    Description of the compulsary project tasks to be carried out as a part of DTU course 72238 Robotics......Description of the compulsary project tasks to be carried out as a part of DTU course 72238 Robotics...

  17. Venezuela's Bolivarian Schools Project.

    Science.gov (United States)

    Diaz, Maria Magnolia Santamaria

    2002-01-01

    Discusses efforts by the Venezuelan government to improve the nation's school infrastructure through the Bolivarian Schools Project administered by the Ministry of Education, Culture and Sport. The project set educational principles which are guiding current school building efforts. (EV)

  18. Project management process.

    Science.gov (United States)

    2007-03-01

    This course provides INDOT staff with foundational knowledge and skills in project management principles and methodologies. INDOTs project management processes provide the tools for interdisciplinary teams to efficiently and effectively deliver pr...

  19. The Alzheimer's Project

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues The Alzheimer's Project Past Issues / Spring 2009 Table of Contents ... of this page please turn Javascript on. The Alzheimer's Project A 4-Part Documentary Series Starting May ...

  20. Capital Projects Application (CPA)

    Data.gov (United States)

    General Services Administration — Capital Projects application (CPA) provides users with the ability to maintain project related financial data for Budget Activity (BA) 51, 55, 64, 01, 02, 03, 04....

  1. Earned value project management

    CERN Document Server

    Fleming, Quentin W

    2010-01-01

    Organizations that follow the principles of good Earned Value Management (EVM) create an environment that allows teams to successfully operate and thrive ? even in the face of challenges that could negatively impact their projects. Earned Value Project Management (EVPM) is a methodology used to measure and communicate the real physical progress of a project taking into account the work completed, the time taken and the costs incurred to complete that work. As a result, EVPM allows more educated and effective management decision-making, which helps evaluate and control project risk by measuring project progress in monetary terms. In the first two editions of Earned Value Project Management, Quentin W. Fleming and Joel M. Koppelman provided guidance for project management practitioners already familiar with EVPM, was well as those who were new to the use of this technique. The third edition expanded the information available on of EVPM for medium and smaller projects while still being relevant for larger projec...

  2. IX Disposition Project - project management plan

    International Nuclear Information System (INIS)

    Choi, I.G.

    1994-01-01

    This report presents plans for resolving saving and disposal concerns for ion exchange modules, cartridge filters and columns. This plan also documents the project baselines for schedules, cost, and technical information

  3. Project Management Performance Drivers

    OpenAIRE

    Ra’ad, Mohammed A.; Najdawi, Mohammad K.

    2010-01-01

    The practice of project management has gained enormous importance over the past several years in various business industries. “In industries as diverse as pharmaceuticals, software, and aerospace, projects drive business” (Wheatley). This gain of importance can be attributed to the magnitude of the impact project performance results in terms of time, cost, and scope have over the project performing entity. “On the basis of data released by the Bureau of Economic Analysis, part of the US De...

  4. Managing clinical improvement projects.

    Science.gov (United States)

    Phillips, Joanna; Simmonds, Lorraine

    This paper, the second of a three-part series looking at change management tools, provides a practical guide on how to use common project management principles in practice. Much of the literature on project management focuses on the business arena, with little reference to clinical settings. Identifying this literature and understanding its relevance to managing projects in healthcare can be difficult. This article provides a practical guide to identifying the key principles of good project management and applying these in health settings.

  5. The Dwarf Project: Vidojevica

    Science.gov (United States)

    Vince, O.

    2013-05-01

    The DWARF project is an important international project for observing eclipsing binary stars and searching for third companion which orbit around both stars. Recently, a group of researchers at the Astronomical Observatory of Belgrade joined this project using the 60 cm telescope at the Astronomical Station Vidojevica for observations. All the equipment and the human potential involved with this project from Serbia will be described in this paper.

  6. Project Management Techniques

    OpenAIRE

    Mihalache Anita; Salagean Liana

    2010-01-01

    Project management is a technique that can aid in the planning, scheduling, and monitoring of complex projects characterized by numerous, non repetitive jobs called activities. Examples of projects that would use project management include: - developing a mass rapid – transit system for a metropolitan area; - organizing the relocation of a corporate headquarters; - planning the production of a concert, film, or play; - developing and marketing a new automobile; - constructing a high – rise of...

  7. Project evaluation: main characteristics

    OpenAIRE

    Moutinho, Nuno

    2010-01-01

    — The evaluation process of real investment projects must consider not only the traditional financial approach, but also non-financial aspects. Non financial analysis can provide additional relevant information about projects. We investigate financial and non-financial areas most relevant in project appraisal. We present main critical success factors and areas of analysis that lead to the perception of project success. Finally, companies are segmented to verify its financial and non-financial...

  8. Project mechanisms challenges

    International Nuclear Information System (INIS)

    Perthuis, Ch. de

    2005-06-01

    The project mechanism complete the quotas systems concerning the carbon dioxide emissions market. The author explains and discusses these mechanisms and provides a panorama of the existing and developing projects. More specially she brings information on the mechanism of clean developments and renewable energies, the coordinated mechanisms, the agricultural projects, the financing of the projects and the exchange systeme of the New south Wales. (A.L.B.)

  9. ORGANIZATIONAL PROJECT MANAGEMENT MATURITY

    Directory of Open Access Journals (Sweden)

    Yana Derenskaya

    2017-11-01

    Full Text Available The present article is aimed at developing a set of recommendations for achieving a higher level of organizational project maturity at a given enterprise. Methodology. For the purposes of the current research, the available information sources on the components of project management system are analysed; the essence of “organizational maturity” and the existing models of organizational maturity are studied. The method of systemic and structural analysis, as well as the method of logical generalization, are employed in order to study the existing models of organizational maturity, to describe levels of organizational maturity, and finally to develop a set of methodological recommendations for achieving a higher level of organizational project maturity at a given enterprise. The results of the research showed that the core elements of project management system are methodological, organizational, programtechnical, and motivational components. Project management encompasses a wide range of issues connected with organizational structure, project team, communication management, project participants, etc. However, the fundamental basis for developing project management concept within a given enterprise starts with defining its level of organizational maturity. The present paper describes various models of organizational maturity (staged, continuous, petal-shaped and their common types (H. Кеrzner Organizational Maturity Model, Berkeley PM Maturity Model, Organizational Project Management Maturity Model, Portfolio, Program & Project Management Maturity Model. The analysis of available theoretic works showed that the notion “organizational project maturity” refers to the capability of an enterprise to select projects and manage them with the intention of achieving its strategic goals in the most effective way. Importantly, the level of maturity can be improved by means of formalizing the acquired knowledge, regulating project-related activities

  10. Pilot Project: analysis, development and projection

    OpenAIRE

    Tapia Abril, Verónica Emilia; Chérrez Rodas, Karina; García Pesántez, Gabriela Rosana; Maldonado Marchán, María Elisa; Bustamante Montesdeoca, José Luis

    2014-01-01

    Since the introduction of ICT in architecture and teaching, pedagogies of education have faced their learning paradigms change. Institutes of higher education have folded to this motion and have undergone a process of change by implementing multimedia elements in their subjects. Through the pilot project educational videos that aim to meet the highest standards of educational videos described by Van Dam have been developed. The project expects to generate educational videos for different depa...

  11. Building Project Competence

    DEFF Research Database (Denmark)

    Pemsel, Sofia; Wiewiora, Anna

    This research investigates the development of project competence, and particularly, three related dynamic capabilities (shifting, adapting, leveraging) that contribute to project competence development. In doing so, we make use of the emerging literature on knowledge governance and theorize how...... of dynamic capability building promoting project competence development....

  12. The Llama Project.

    Science.gov (United States)

    Ganzel, Candy; Stuglik, Jan

    2003-01-01

    At a suburban Indiana elementary school, the Project Approach serves as the basis of the curriculum in all Kindergarten classrooms. The four classes of 5- and 6-year-old children at this school chose to study llamas. This article discusses how the project evolved, describes the three phases of the project, and provides teachers' reflections on the…

  13. Nuclear safety projects 1995

    International Nuclear Information System (INIS)

    Carl-Erik Christoffersen

    1996-01-01

    Action plans for the prevention of contamination in the Arctic regions is concretized in a number of international projects. The Norwegian Radiation Protection Authority is responsible for the follow-up of 13 projects. The report describes the development of these projects in 1995

  14. Projection: A Bibliography.

    Science.gov (United States)

    Pedrini, D. T.; Pedrini, Bonnie C.

    Sigmund Freud and his associates did much clinical work with the dynamic of projection, especially with regard to paranoid symptoms and syndromes. Much experimental work has also been done with projection. Sears evaluated the results of some of those studies. Murstein and Pryer sub-classified projection and reviewed typical studies. The…

  15. Mayan Forest Road Projects

    DEFF Research Database (Denmark)

    Conde, Dalia Amor

    2008-01-01

    Road-building projects in the Mayan Biosphere Reserve to connect Mexico and Guatemala were subjected to a cost-benefit evaluation. Up to an estimated 311,000 hectares of jaguar habitat were found to be at risk of deforestation due to these projects. Some of the projects were shown to have negativ...... of continued conservation rather than road development....

  16. Projection Models 2010

    DEFF Research Database (Denmark)

    Illerup, J. B.; Birr-Pedersen, K.; Mikkelsen, M. H

    Models for projection of SO2-, NOx-, NMVOC- and NH3-emissions to the atmosphere have been developed and the Danish emissions have been projected until 2010 from a basis scenario including all implemented and planned measures. The projections of the four pollutants indicate that it may be difficult...

  17. Project Communications Management

    OpenAIRE

    José C. Santiago-Guevara; Mauricio Rojas-Contreras; Luis A. Esteban-Villamizar

    2013-01-01

    This article presents a review in relation to the object of study: Communications Management as an important factor in the management of projects. The review includes the most relevant and most renowned authors in the field of project management, focusing on telecommunications projects, which lets you define a communications management model.

  18. Designing Project Management

    NARCIS (Netherlands)

    Heintz, John Linke; Lousberg, L.; Wamelink, J.W.F.; Saari, A.; Huovinen, P.

    2016-01-01

    In this paper we introduce the concept of Designing Project Management. On the basis of our earlier work, we suggest that there is still a gap between what is known from recent project management literature and what project managers can structurally help in the effectiveness of their work. Assuming

  19. Humane Education Projects Handbook.

    Science.gov (United States)

    Junior League of Ogden, UT.

    This handbook was developed to promote interest in humane education and to encourage the adoption of humane education projects. Although specifically designed to assist Junior Leagues in developing such projects, the content should prove valuable to animal welfare organizations, zoos, aquariums, nature centers, and other project-oriented groups…

  20. MRS project management

    International Nuclear Information System (INIS)

    Doman, J.W.; Vlahakis, J.

    1992-01-01

    Management of projects under the control of the Office of Civilian Radioactive Waste Management within the Department of Energy is subject to overview by a variety of internal and external entities. This paper reports that effective project management often requires balancing of conflicting directions and conflicting agendas of the different entities in order to proceed with implementation of the Monitored Retrievable Storage project

  1. Risks management in project planning

    OpenAIRE

    Stankevičiūtė, Roberta

    2017-01-01

    Project management consists of two very important aspects – managing the right project and managing the project right. To know that you are managing the right project you need to ensure that your project is based on an actual requirement and that your project goal is relevant and beneficial. And professional project planning assists in managing project the right way. The project planning process is very time consuming and is one of the most important parts of the project management process. T...

  2. Project report - an overview of the project and experiences with project management

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard; Mikkelsen, Bent Egberg

    1996-01-01

    A collection of the project planning and the experiences with project management from the Catering 2000 project.As appendieces articles etc. from journals, newspapers etc. about the project.......A collection of the project planning and the experiences with project management from the Catering 2000 project.As appendieces articles etc. from journals, newspapers etc. about the project....

  3. FY 1977 Annual report on Sunshine Project results. Research and development of photovoltaic power generation systems. (Research and development of solar cells of II-VI group compound semiconductor); 1977 nendo taiyoko hatsuden system no kenkyu kaihatsu seika hokokusho. II-VI zoku kagobutsu handotai taiyo denchi no kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1978-03-31

    This project is aimed at establishment of techniques for pollution-free production of II-VI group compound semiconductor type solar cells. The research items are (1) measures against aging, (2) methods for production of II-VI group compound semiconductors and for forming their joints, and (3) method for assembling solar cell devices.For the item (1), the aging tests are conducted for sintered film type CdS/CdTe solar cells. The C electrode is found to be less aged than the others. The aging tests for the CdS/Cu{sub 2}S cells indicate that it takes 10 years or longer for the performance to be halved under commercial conditions. For the item (2), the sintered film type CdS/CdTe solar cells can be produced by a mass-producible process of screen printing and belt furnace. This production method is promising for producing the solar cells at low cost. For the item (3), it is found that series resistance of the solar cell devices increases as the assembly area increases, resulting in decreased conversion efficiency. The divided structure of the CdTe layer is desired to avoid the above problem. Dividing each unit device increases intrinsic conversion efficiency, but decreases effective power generation area ratio. It is therefore necessary to improve printing precision. (NEDO)

  4. Underestimation of Project Costs

    Science.gov (United States)

    Jones, Harry W.

    2015-01-01

    Large projects almost always exceed their budgets. Estimating cost is difficult and estimated costs are usually too low. Three different reasons are suggested: bad luck, overoptimism, and deliberate underestimation. Project management can usually point to project difficulty and complexity, technical uncertainty, stakeholder conflicts, scope changes, unforeseen events, and other not really unpredictable bad luck. Project planning is usually over-optimistic, so the likelihood and impact of bad luck is systematically underestimated. Project plans reflect optimism and hope for success in a supposedly unique new effort rather than rational expectations based on historical data. Past project problems are claimed to be irrelevant because "This time it's different." Some bad luck is inevitable and reasonable optimism is understandable, but deliberate deception must be condemned. In a competitive environment, project planners and advocates often deliberately underestimate costs to help gain project approval and funding. Project benefits, cost savings, and probability of success are exaggerated and key risks ignored. Project advocates have incentives to distort information and conceal difficulties from project approvers. One naively suggested cure is more openness, honesty, and group adherence to shared overall goals. A more realistic alternative is threatening overrun projects with cancellation. Neither approach seems to solve the problem. A better method to avoid the delusions of over-optimism and the deceptions of biased advocacy is to base the project cost estimate on the actual costs of a large group of similar projects. Over optimism and deception can continue beyond the planning phase and into project execution. Hard milestones based on verified tests and demonstrations can provide a reality check.

  5. Seventh Edition Fuel Cell Handbook

    Energy Technology Data Exchange (ETDEWEB)

    NETL

    2004-11-01

    Provides an overview of fuel cell technology and research projects. Discusses the basic workings of fuel cells and their system components, main fuel cell types, their characteristics, and their development status, as well as a discussion of potential fuel cell applications.

  6. Description of the EuroTARGET cohort: A European collaborative project on TArgeted therapy in renal cell cancer-GEnetic- and tumor-related biomarkers for response and toxicity.

    Science.gov (United States)

    van der Zanden, Loes F M; Vermeulen, Sita H; Oskarsdottir, Arna; Maurits, Jake S F; Diekstra, Meta H M; Ambert, Valentin; Cambon-Thomsen, Anne; Castellano, Daniel; Fritsch, Achim; Garcia Donas, Jesus; Guarch Troyas, Rosa; Guchelaar, Henk-Jan; Hartmann, Arndt; Hulsbergen-van de Kaa, Christina; Jaehde, Ulrich; Junker, Kerstin; Martinez-Cardus, Anna; Masson, Gisli; Oosterwijk-Wakka, Jeannette; Radu, Marius T; Rafnar, Thorunn; Rodriguez-Antona, Cristina; Roessler, Max; Ruijtenbeek, Rob; Stefansson, Kari; Warren, Anne; Wessels, Lodewyk; Eisen, Tim; Kiemeney, Lambertus A L M; Oosterwijk, Egbert

    2017-08-01

    For patients with metastatic renal cell cancer (mRCC), treatment choice is mainly based on clinical parameters. With many treatments available and the limited response to treatment and associated toxicities, there is much interest in identifying better biomarkers for personalized treatment. EuroTARGET aims to identify and characterize host- and tumor-related biomarkers for prediction of response to tyrosine kinase inhibitor therapy in mRCC. Here, we describe the EuroTARGET mRCC patient cohort. EuroTARGET is a European collaborative project designed as an observational study for which patients with mRCC were recruited prospectively in 62 centers. In addition, 462 patients with mRCC from previous studies were included. Detailed clinical information (baseline and follow-up) from all patients was entered in web-based case record forms. Blood was collected for germline DNA and pharmacokinetic/pharmacodynamic analyses and, where available, fresh-frozen tumor material was collected to perform tumor DNA, RNA, kinome, and methylome analyses. In total, 1,210 patients with mRCC were included. Of these, 920 received a tyrosine kinase inhibitor as first-line targeted treatment (sunitinib [N = 713, 78%], sorafenib [N = 41, 4%], or pazopanib [N = 166, 18%]) and had at least 6 months of outcome assessment (median follow-up 15.3 months [interquartile range: 8.5-30.2 months]). Germline DNA samples were available from 824 of these patients, fresh-frozen tumor material from 142 patients, fresh-frozen normal kidney tissue from 95 patients, and tissue microarrays created from formalin-fixed paraffin-embedded tumor material from 247 patients. Of the 920 patients, germline DNA variant chip data were successfully generated for 811 patients (Illumina HumanOmniExpress BeadChip). For 80 patients, next-generation exome sequencing of germline and tumor DNA was performed, tumor RNA sequencing was performed for 124 patients, kinome activity measured and processed for 121 patients (PamChip), and

  7. Fundamentals of Project Management

    CERN Document Server

    Heagney, Joseph

    2011-01-01

    With sales of more than 160,000 copies, Fundamentals of Project Management has helped generations of project managers navigate the ins and outs of every aspect of this complex discipline. Using a simple step-by-step approach, the book is the perfect introduction to project management tools, techniques, and concepts. Readers will learn how to: ò Develop a mission statement, vision, goals, and objectives ò Plan the project ò Create the work breakdown structure ò Produce a workable schedule ò Understand earned value analysis ò Manage a project team ò Control and evaluate progress at every stage.

  8. Visualizations as Projection Devices

    DEFF Research Database (Denmark)

    Harty, Chris; Holm Jacobsen, Peter; Tryggestad, Kjell

    The aim of this paper is to inquire into the role of project visualizations in shaping healthcare spaces and practices. The study draws upon an ethnographic field study from a large on-going hospital construction project in Denmark, and focuses on the early phases of on-boarding the design team...... into the project organization. During the on-boarding visualizations multiplies in form, content and purpose, ranging from paper and digitally based projections of clinical work spaces and practices for the future hospital building in use, to paper and digitally based projections of the cost budget and time...

  9. Managing Projects with KPRO

    Science.gov (United States)

    Braden, Barry M.

    2004-01-01

    How does a Project Management Office provide: Consistent, familiar, easily used scheduling tools to Project Managers and project team members? Provide a complete list of organization resources available for use on the project? Facilitate resource tracking and visibility? Provide the myriad reports that the organization requires? Facilitate consistent budget planning and cost performance information? Provide all of this to the entire organization? Provide for the unique requirement of the organization? and get people to use it? Answer: Implementation of the Kennedy space Center Projects and Resources Online (KPRO), a modified COTS solution.

  10. Project Decision Chain

    DEFF Research Database (Denmark)

    Rolstadås, Asbjørn; Pinto, Jeffrey K.; Falster, Peter

    2015-01-01

    To add value to project performance and help obtain project success, a new framework for decision making in projects is defined. It introduces the project decision chain inspired by the supply chain thinking in the manufacturing sector and uses three types of decisions: authorization, selection......, and plan decision. A primitive decision element is defined where all the three decision types can be accommodated. Each task in the primitive element can in itself contain subtasks that in turn will comprise new primitive elements. The primitive elements are nested together in a project decision chain....

  11. Scheduling for decommissioning projects

    International Nuclear Information System (INIS)

    Podmajersky, O.E.

    1987-01-01

    This paper describes the Project Scheduling system being employed by the Decommissioning Operations Contractor at the Shippingport Station Decommissioning Project (SSDP). Results from the planning system show that the project continues to achieve its cost and schedule goals. An integrated cost and schedule control system (C/SCS) which uses the concept of earned value for measurement of performance was instituted in accordance with DOE orders. The schedule and cost variances generated by the C/SCS system are used to confirm management's assessment of project status. This paper describes the types of schedules and tools used on the SSDP project to plan and monitor the work, and identifies factors that are unique to a decommissioning project that make scheduling critical to the achievement of the project's goals. 1 fig

  12. Managing Distributed Software Projects

    DEFF Research Database (Denmark)

    Persson, John Stouby

    Increasingly, software projects are becoming geographically distributed, with limited face-toface interaction between participants. These projects face particular challenges that need careful managerial attention. This PhD study reports on how we can understand and support the management...... of distributed software projects, based on a literature study and a case study. The main emphasis of the literature study was on how to support the management of distributed software projects, but also contributed to an understanding of these projects. The main emphasis of the case study was on how to understand...... the management of distributed software projects, but also contributed to supporting the management of these projects. The literature study integrates what we know about risks and risk-resolution techniques, into a framework for managing risks in distributed contexts. This framework was developed iteratively...

  13. ASEAN projects reviewed.

    Science.gov (United States)

    1980-01-01

    The ASEAN Population Expert Group met in Manila and was followed by a meeting of the ASEAN heads of population programs, during the period November 5-10, 1979. Heads of population programs from Indonesia, Malaysia, Singapore, Thailand, and the Philippines attended. The meetings were held to review progress-to-date on phase 1 projects and to consider the development of an expanded population program. 5 projects funded by UNFPA are reviewed in tabular form with the project, the sponsoring country, date of implementation, data analysis, and date of completion. Suggestions were made for improving and extending these projects and it was also suggested that all projects being developed and proposed should include a section on use of research. 7 new projects were proposed as phase 2 projects. The 1st, sponsored by Malaysia, deals with women in development; project 2, lead by Thailand, will investigate population movement and its effect on development; project 3, led by the Philippines, will develop and strengthen national population information systems and networks in ASEAN countries; project 4, led by Indonesia, is directed towards institutional development and exchanges of personnel; project 5, led by the Philippines, will examine population and development dynamics and the man/resources balance; project 6, led by Thailand, will develop ASEAN social indicators; and project 7, led by Indonesia and Malaysia, will make a comprehensive analysis of existing medical/health care and family planning systems. It was recommended that an executive director of the proposed ASEAN population coordination unit should be appointed to expedite the recommendations of the meeting related to preparation and submission of phase 2 project proposals.

  14. Photovoltaic Programme, Edition 2006. Summary report. Project list. Annual project reports 2005 (abstracts)

    Energy Technology Data Exchange (ETDEWEB)

    Nowak, S.

    2006-07-01

    This comprehensive, illustrated report for the Swiss Federal Office of Energy (SFOE) presents an overview of the work done as part of the 2005 research programme, along with the abstracts of the annual reports of the project leaders on research projects. It presents the programme's main points of focus, discusses the work done and the results obtained. Areas covered include cell technology (13 reports), solar modules and building integration (3 reports) , system technology (4 reports) as well as various further projects (5) that are connected with photovoltaics. Four further reports concern international co-operation. Further, several pilot and demonstration (P+D) projects are discussed. Lists of all research and development projects and pilot and demonstration projects are supplied. Work done at several institutions in Switzerland and at leading commercial companies is described.

  15. Perspectives on projects, project success and team work

    OpenAIRE

    Thompson, Karen

    2015-01-01

    This paper brings together perspectives on projects, project success and team work as a background to two graphical tools for considering project success and individual capabilities for working in a project team.

  16. Quality Assurance Project Plan for Citizen Science Projects

    Science.gov (United States)

    The Quality Assurance Project Plan is necessary for every project that collects or uses environmental data. It documents the project planning process and serves as a blueprint for how your project will run.

  17. Project Management and the Project Manager: A Strategy for ...

    African Journals Online (AJOL)

    International Journal of Development and Management Review ... collapse, project failure, project abandonment, project cost and time overruns, etc. ... component parts that constitute project management in the building construction industry.

  18. Theory of Abelian projection

    International Nuclear Information System (INIS)

    Ogilvie, M.C.

    1999-01-01

    Analytic methods for Abelian projection are developed. A number of results are obtained related to string tension measurements. It is proven that even without gauge fixing, Abelian projection yields string tensions of the underlying non-Abelian theory. Strong arguments are given for similar results in the case where gauge fixing is employed. The methods used emphasize that the projected theory is derived from the underlying non-Abelian theory rather than vice versa. In general, the choice of subgroup used for projection is not very important, and need not be Abelian. While gauge fixing is shown to be in principle unnecessary for the success of Abelian projection, it is computationally advantageous for the same reasons that improved operators, e.g., the use of fat links, are advantageous in Wilson loop measurements. Two other issues, Casimir scaling and the conflict between projection and critical universality, are also discussed. copyright 1999 The American Physical Society

  19. Battleground Energy Recovery Project

    Energy Technology Data Exchange (ETDEWEB)

    Bullock, Daniel [USDOE Gulf Coast Clean Energy Application Center, Woodlands, TX (United States)

    2011-12-31

    In October 2009, the project partners began a 36-month effort to develop an innovative, commercial-scale demonstration project incorporating state-of-the-art waste heat recovery technology at Clean Harbors, Inc., a large hazardous waste incinerator site located in Deer Park, Texas. With financial support provided by the U.S. Department of Energy, the Battleground Energy Recovery Project was launched to advance waste heat recovery solutions into the hazardous waste incineration market, an area that has seen little adoption of heat recovery in the United States. The goal of the project was to accelerate the use of energy-efficient, waste heat recovery technology as an alternative means to produce steam for industrial processes. The project had three main engineering and business objectives: Prove Feasibility of Waste Heat Recovery Technology at a Hazardous Waste Incinerator Complex; Provide Low-cost Steam to a Major Polypropylene Plant Using Waste Heat; and Create a Showcase Waste Heat Recovery Demonstration Project.

  20. J-PARC project

    International Nuclear Information System (INIS)

    Nagamiya, Shoji

    2004-01-01

    From Japanese fiscal year JFY01, which started on April 1, 2001, a new accelerator project to provide high-intensity proton beams proceeded into its construction phase. This project, which is now called the Japan Proton Accelerator Research Complex (J-PARC) project, is conducted under a cooperation of two institutions, KEK and Japan Atomic Energy Research Institution. We set a goal to achieve 1 MW proton beams at 3 GeV and 0.75 MW beams at 50 GeV. The project will be completed within six years, with the anticipated first beams in the spring of 2007. In this article I will describe (a) the project itself, (b) sciences to be pursued at this new accelerator complex and (c) the present status and future plans of the project

  1. Photovoltaic demonstration projects

    Energy Technology Data Exchange (ETDEWEB)

    Kaut, W [Commission of the European Communities, Brussels (Belgium); Gillett, W B; Hacker, R J [Halcrow Gilbert Associates Ltd., Swindon (GB)

    1992-12-31

    This publication, comprising the proceedings of the fifth contractor`s meeting organized by the Commission of the European Communities, Directorate-General for Energy, provides an overview of the photovoltaic demonstration projects which have been supported in the framework of the energy demonstration programme since 1983. It includes reports by each of the contractors who submitted proposals in 1987 and 1988, describing progress within their projects. Projects accepted from earlier calls for proposals and not yet completed were reviewed by a rapporteur and are discussed in the summary section. The results of the performance monitoring of all projects and the lessons drawn from the practical experience of the projects are also presented in the summaries and conclusions. Contractors whose projects were submitted in 1989 were also present at the meeting and contributed to the reported discussions. This proceeding is divided into four sessions (General, Housing, technical presentations, other applications) and 24 papers are offered.

  2. AAEC nuclear power projections

    International Nuclear Information System (INIS)

    Khoe, G.; Fredsall, J.; Scurr, I.; Plotnikoff, W.

    1981-01-01

    The nuclear power capacity projections developed in the May-June period of 1981 by the AAEC are presented. There have been downward revisions for nearly all countries with centrally planned economies. Projections for the year 2000 for the Western World have decreased in aggregate by 4.7% (27Gw) compared to those of 1980. However, this reduction is less than the previous estimate reduction and there appears to have been a stabilisation in the projection

  3. What is project finance?

    OpenAIRE

    João M. Pinto

    2017-01-01

    Project finance is the process of financing a specific economic unit that the sponsors create, in which creditors share much of the venture’s business risk and funding is obtained strictly for the project itself. Project finance creates value by reducing the costs of funding, maintaining the sponsors financial flexibility, increasing the leverage ratios, avoiding contamination risk, reducing corporate taxes, improving risk management, and reducing the costs associated with market ...

  4. Computer Assets Recovery Project

    Science.gov (United States)

    CortesPena, Aida Yoguely

    2010-01-01

    This document reports on the project that was performed during the internship of the author. The project involved locating and recovering machines in various locations that Boeing has no need for, and therefore requires that they be transferred to another user or transferred to a non-profit organization. Other projects that the author performed was an inventory of toner and printers, loading new computers and connecting them to the network.

  5. Operational Waste Volume Projection

    Energy Technology Data Exchange (ETDEWEB)

    STRODE, J.N.

    2000-08-28

    Waste receipts to the double-shell tank system are analyzed and wastes through the year 2015 are projected based on generation trends of the past 12 months. A computer simulation of site operations is performed, which results in projections of tank fill schedules, tank transfers, evaporator operations, tank retrieval, and aging waste tank usage. This projection incorporates current budget planning and the clean-up schedule of the Tri-Party Agreement. Assumptions were current as of June. 2000.

  6. Organization of project management

    International Nuclear Information System (INIS)

    Schmidt, R.

    1975-01-01

    When speaking about interfaces within a project and their management, one has to understand and define what an interface is. In general, each component facing another one and each person working on a project with another person represents an interface. Therefore a project will consist practically in its entirety of interfaces with components and people sandwiched between them. This paper is limited to the most important interfaces with a focus on the problems occuring at them and their resolution. (orig.) [de

  7. Operational waste volume projection

    International Nuclear Information System (INIS)

    Koreski, G.M.; Strode, J.N.

    1995-06-01

    Waste receipts to the double-shell tank system are analyzed and wastes through the year 2015 are projected based on generation trends of the past 12 months. A computer simulation of site operations is performed, which results in projections of tank fill schedules, tank transfers, evaporator operations, tank retrieval, and aging waste tank usage. This projection incorporates current budget planning and the clean-up schedule of the tri-party agreement. Assumptions are current as of June 1995

  8. PPP projects in transport

    DEFF Research Database (Denmark)

    Petersen, Ole Helby; Carpintero, Samuel

    2014-01-01

    Public–private partnerships (PPPs) have been extensively used in Spain for the procurement of light rail systems. This paper analyses five projects that have been in operation for more than five years. The authors examine the reasoning behind the selection of the PPP projects, risk......-sharing mechanisms, competition among private providers, and overall cost-effectiveness. The paper demonstrates a need for more rigorous assessments of the merits of PPP projects before they are initiated....

  9. Operational Waste Volume Projection

    International Nuclear Information System (INIS)

    STRODE, J.N.

    2000-01-01

    Waste receipts to the double-shell tank system are analyzed and wastes through the year 2015 are projected based on generation trends of the past 12 months. A computer simulation of site operations is performed, which results in projections of tank fill schedules, tank transfers, evaporator operations, tank retrieval, and aging waste tank usage. This projection incorporates current budget planning and the clean-up schedule of the Tri-Party Agreement. Assumptions were current as of June. 2000

  10. Existence of Projective Planes

    OpenAIRE

    Perrott, Xander

    2016-01-01

    This report gives an overview of the history of finite projective planes and their properties before going on to outline the proof that no projective plane of order 10 exists. The report also investigates the search carried out by MacWilliams, Sloane and Thompson in 1970 [12] and confirms their result by providing independent verification that there is no vector of weight 15 in the code generated by the projective plane of order 10.

  11. Microwave solidification project overview

    Energy Technology Data Exchange (ETDEWEB)

    Sprenger, G.

    1993-01-01

    The Rocky Flats Plant Microwave Solidification Project has application potential to the Mixed Waste Treatment Project and the The Mixed Waste Integrated Program. The technical areas being addressed include (1) waste destruction and stabilization; (2) final waste form; and (3) front-end waste handling and feed preparation. This document covers need for such a program; technology description; significance; regulatory requirements; and accomplishments to date. A list of significant reports published under this project is included.

  12. Oskarshamn 1-project FENIX

    International Nuclear Information System (INIS)

    Sjoeqvist, N.G.

    1994-01-01

    This paper summarizes the actions to be taken in a large re-start and backfitting project such as the Fenix project. It describes the organization, planning and financial management, safety criteria and licensing procedures, safety concept report, health and safety. The results from the unique full system decontamination of the reactor pressure vessel is described. The project is still ongoing and therefore other results and lessons learnt are not reported. (author) 9 figs

  13. Microwave solidification project overview

    International Nuclear Information System (INIS)

    Sprenger, G.

    1993-01-01

    The Rocky Flats Plant Microwave Solidification Project has application potential to the Mixed Waste Treatment Project and the The Mixed Waste Integrated Program. The technical areas being addressed include (1) waste destruction and stabilization; (2) final waste form; and (3) front-end waste handling and feed preparation. This document covers need for such a program; technology description; significance; regulatory requirements; and accomplishments to date. A list of significant reports published under this project is included

  14. Initial Results of Peripheral-Blood Stem-Cell Mobilization, Collection, Cryopreservation, and Engraftment After Autologous Transplantation Confirm That the Capacity-Building Approach Offers Good Chances of Success in Critical Contexts: A Kurdish-Italian Cooperative Project at the Hiwa Cancer Hospital, Sulaymaniyah

    Directory of Open Access Journals (Sweden)

    Ignazio Majolino

    2017-12-01

    Full Text Available Introduction: At Hiwa Cancer Hospital (Sulaymaniyah, Iraqi Kurdistan after the center was started by a cooperative project in June 2016, autologous transplantation was developed. Patients and Methods: To develop the project, the capacity-building approach was adopted, with on-site training and coaching of personnel, educational meetings, lectures, on-the-job training, and the implementation of quality management planning. Results: Here, we report initial results of peripheral-blood stem-cell mobilization and collection of the first 27 patients (age 12 to 61 years; 19 males and 8 females; multiple myeloma, n = 10; plasma cell leukemia, n = 1; Hodgkin lymphoma, n = 12; non-Hodgkin lymphoma, n = 3; and acute myeloid leukemia, n = 1. Only three (11.5% of 26 patients experienced a failure of mobilization. A median of 6.1 × 106/kg CD34-positive cells per patient were collected (range, 2.4 to 20.8, with two apheretic runs. Twenty-four patients underwent autologous transplantation. All but one transplantation engrafted fully and steadily, with 0.5 and 1.0 × 109/L polymorphonucleates on day 10.5 (range, 8 to 12 and day 11 (range, 9 to 15, respectively, and with 20 and 50 × 109/L platelets on day 13 (range, 10 to 17 and day 17 (range, 2 to 44, respectively. More than 95% of patients are projected to survive 1 year after autograft. Conclusion: These data are the result of an Italian effort to establish in Iraqi Kurdistan a leading center for hemopoietic stem-cell transplantation. The capacity building approach was used, with on-site training and coaching as instruments for the development of provider ability and problem solving. With future limitations for immigration, this method will be helpful, especially in the field of high-technology medicine.

  15. Embedded Linux projects using Yocto project cookbook

    CERN Document Server

    González, Alex

    2015-01-01

    If you are an embedded developer learning about embedded Linux with some experience with the Yocto project, this book is the ideal way to become proficient and broaden your knowledge with examples that are immediately applicable to your embedded developments. Experienced embedded Yocto developers will find new insight into working methodologies and ARM specific development competence.

  16. Project Risk Management

    Science.gov (United States)

    Jr., R. F. Miles

    1995-01-01

    Project risk management is primarily concerned with performance, reliability, cost, and schedule. Environmental risk management is primarily concerned with human health and ecological hazards and likelihoods. This paper discusses project risk management and compares it to environmental risk management, both with respect to goals and implementation. The approach of the Jet Propulsion Laboratory to risk management is presented as an example of a project risk management approach that is an extension to NASA NHB 7120.5: Management of Major System Programs and Projects.

  17. HERMES project management I

    CERN Multimedia

    CERN. Geneva

    2013-01-01

    A two-hours course on the HERMES Project Management Methodology to the attention of Project Leaders and Project Participants. The methodology is quickly presented; the focus is put on the roles and responsibilities and on the project initiation phase. The course is given in French with slides in English. On April 22nd 2013, a new version of the HERMES methodology was made public. For practical reasons, this course is still given based on the 2009 version of HERMES (a.k.a. HERMES 4).

  18. Scrum Project Management

    CERN Document Server

    Pries, Kim H

    2010-01-01

    Scrum, which was originally invented solely for software development, can now be applied to all types of projects. This book shows project managers how to implement Scrum by explaining the artifacts, rituals, and roles used. The text provides Scrum planning methods to control project scope and schedule as well as Scrum tracking methods to focus teams on improving throughput and streamlining communications. The authors show how to combine traditional project methods with Scrum and how to adapt the familiar work breakdown structure to create Scrum backlogs and sprints. They also demonstrate how

  19. Severe fuel damage projects

    International Nuclear Information System (INIS)

    Sdouz, G.

    1987-10-01

    After the descriptions of the generation of a Severe Fuel Damage Accident in a LWR the hypothetical course of such an accident is explained. Then the most significant projects are described. At each project the experimental facility, the most important results and the concluding models and codes are discussed. The selection of the projects is concentrated on the German Projekt Nukleare Sicherheit (PNS), tests performed at the Idaho National Engineering Laboratory (INEL) and smaller projects in France and Great Britain. 25 refs., 26 figs. (Author)

  20. Assessment of Students Projects

    DEFF Research Database (Denmark)

    Kofoed, Lise B.; Stachowicz, Marian S.

    2012-01-01

    The evaluation and assessment of engineering programmes is a big issue, and there exist many concepts and methods. This paper deals with the assessment methods which can be used when assessing the knowledge, skills and competences developed in projects using PBL (problem based and project organized...... learning) pedagogical approaches. The experience of assessing first year projects from the Medialogy education at Aalborg University and third year projects from the Electrical and Computer Engineering Department at University of Minnesota, Duluth are presented, and the different methods discussed....... The conclusion is that process as well as product has to be assessed in a way which evaluates all aspects of students’ learning outcomes....

  1. The HGF strategy project

    International Nuclear Information System (INIS)

    Knebel, J.U.; Fellmoser, F.; Lefhalm, C.; Mack, K.; Pettan, C.; Piecha, H.; Konys, J.; Adelhelm, C.; Glasbrenner, H.; Muscher, H.; Novotny, J.; Voss, Z.; Wedemeyer, O.; Mueller, G.; Heinzel, A.; Schumacher, G.; Huber, R.; Zimmermann, F.; Groetzbach, G.; Dorr, B.; Carteciano, L.N.

    2000-01-01

    Within the Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF) an HGF-Strategy Fund Project entitled 'Innovative Technologies to Reduce Radiotoxicity' is funded since October 1999. The objectives of this HGF-Strategy Fund Project is the development of new methods and technologies to design and manufacture thin-walled and highly thermally-loaded surfaces which are cooled by a corrosive heavy liquid metal (lead-bismuth eutectic). The result of this project will be the basic scientific-technical tool which allows the conception and the design of a European Demonstrator of an ADS system (cf. 32.23.05). The work performed at Forschungszentrum Karlsruhe is embedded in a broad European research and development programme on ADS systems. The project is divided in three sub-projects: Sub-Project 1: Thermalhydraulic Investigations, Sub-Project 2: Material Specific Investigations, Sub-Project 3: Oxygen Control System. This progress report gives a general description of the project and its envisaged objectives. As a selection of the results achieved, first, FLUTAN calculations for the COULI beam window design and, second, the oxygen control system for the KArlsruhe Lead LAboratory KALLA are described in detail. Finally, the design and status of KALLA is given. (orig.)

  2. Environmental Science: 49 Science Fair Projects. Science Fair Projects Series.

    Science.gov (United States)

    Bonnet, Robert L.; Keen, G. Daniel

    This book contains 49 science fair projects designed for 6th to 9th grade students. Projects are organized by the topics of soil, ecology (projects in habitat and life cycles), pests and controls (projects in weeds and insects), recycling (projects in resources and conservation), waste products (projects in decomposition), microscopic organisms,…

  3. The CHPRC Columbia River Protection Project Quality Assurance Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    Fix, N. J.

    2008-11-30

    Pacific Northwest National Laboratory researchers are working on the CHPRC Columbia River Protection Project (hereafter referred to as the Columbia River Project). This is a follow-on project, funded by CH2M Hill Plateau Remediation Company, LLC (CHPRC), to the Fluor Hanford, Inc. Columbia River Protection Project. The work scope consists of a number of CHPRC funded, related projects that are managed under a master project (project number 55109). All contract releases associated with the Fluor Hanford Columbia River Project (Fluor Hanford, Inc. Contract 27647) and the CHPRC Columbia River Project (Contract 36402) will be collected under this master project. Each project within the master project is authorized by a CHPRC contract release that contains the project-specific statement of work. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by the Columbia River Project staff.

  4. The CHPRC Columbia River Protection Project Quality Assurance Project Plan

    International Nuclear Information System (INIS)

    Fix, N.J.

    2008-01-01

    Pacific Northwest National Laboratory researchers are working on the CHPRC Columbia River Protection Project (hereafter referred to as the Columbia River Project). This is a follow-on project, funded by CH2M Hill Plateau Remediation Company, LLC (CHPRC), to the Fluor Hanford, Inc. Columbia River Protection Project. The work scope consists of a number of CHPRC funded, related projects that are managed under a master project (project number 55109). All contract releases associated with the Fluor Hanford Columbia River Project (Fluor Hanford, Inc. Contract 27647) and the CHPRC Columbia River Project (Contract 36402) will be collected under this master project. Each project within the master project is authorized by a CHPRC contract release that contains the project-specific statement of work. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by the Columbia River Project staff

  5. Sustainable Energy (SUSEN) project

    International Nuclear Information System (INIS)

    Richter, Jiri

    2012-01-01

    Research Centre Rez and University of West Bohemia started preparatory work on the 'Sustainable Energy' project, financed from EU structural funds. The goals and expected results of the project, its organization, estimated costs, time schedule and current status are described. (orig.)

  6. Managing Stress. Project Seed.

    Science.gov (United States)

    Muto, Donna; Wilk, Jan

    One of eight papers from Project Seed, this paper describes a stress management project undertaken with high school sophomores. Managing Stress is described as an interactive workshop that offers young people an opportunity to examine specific areas of stress in their lives and to learn effective ways to deal with them. The program described…

  7. The Cool Colors Project

    Science.gov (United States)

    Gov. Arnold Schwarzenegger, second from left, a sample from the Cool Colors Project, a roof product ) (Jeff Chiu - AP) more Cool Colors make the front page of The Sacramento Bee (3rd highest circulation newspaper in California) on 14 August 2006! Read the article online or as a PDF. The Cool Colors Project

  8. Lower Churchill project

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, B. [Nalcor Energy, St. John' s, Newfoundland (Canada)

    2011-07-01

    This paper discusses the Lower Churchill Hydroelectric Generation Project in Newfoundland Labrador. The project is of national interest as it creates jobs and benefits across Canada. It provides inter provincial electricity grid integration, provides significant contribution to lower emissions and enables development of other renewable generation.

  9. Poverty alleviation project review

    CSIR Research Space (South Africa)

    Braun, AL

    2003-01-01

    Full Text Available seven pure cashmere rams from project. EC (Emerging farmers) farmers have also received 43 upgraded cashmere rams from Dept. of Agric. EC From the plus minus 1800 goats involved in the project at least 450 kids / offspring of the improved goats have been...

  10. Conservation Science Fair Projects.

    Science.gov (United States)

    Soil Conservation Society of America, Ankeny, IA.

    Included are ideas, suggestions, and examples for selecting and designing conservation science projects. Over 70 possible conservation subject areas are presented with suggested projects. References are cited with each of these subject areas, and a separate list of annotated references is included. The references pertain to general subject…

  11. The ANTARES project

    International Nuclear Information System (INIS)

    Amram, Ph.; Anvar, S.; Aslanides, E.; Aubert, J.J.; Azoulay, R.; Basa, S.; Benhammou, Y.; Bernard, F.; Berthier, R.; Bertin, V.; Billault, M.; Biller, S.; Blanc, F.; Blanc, P.E.; Bland, R.W.; Blondeau, F.; Botton, N. de; Bottu, N.; Boulesteix, J.; Brooks, B.; Brunner, J.; Calzas, A.; Carloganu, C.; Carr, J.; Carton, P.H.; Cartwright, S.; Cases, R.; Cassol, F.; Charles, F.; Charles, J.; Desages, F.; Destelle, J.J.; Dispau, G.; Duval, P.Y.; Engelen, J.; Feinstein, F.; Flores, E.C.; Fopma, J.; Fuda, J.L.; Goret, P.; Gosset, L.; Gournay, J.F.; Hernandez, J.J.; Hubaut, F.; Hubbard, R.; Huss, D.; Jaquet, M.; Jelley, N.; Kajfasz, E.; Kouchner, A.; Kudryavtsev, V.; Lachartre, D.; Lafoux, H.; Lamare, P.; Languillat, J.C.; Laugier, J.P.; Le Provost, H.; Loiseau, D.; Loucatos, S.; Magnier, P.; Marc, K.; Marcelin, M.; Martin, L.; Mazeau, B.; Mazure, A.; McMillan, J.; Meessen, C.; Millot, C.; Mols, P.; Montanet, F.; Moorhead, M.; Moscoso, L.; Navas, S.; Nooren, Van; Olivetto, C.; Palanque-Delabrouille, N.; Pallares, A.; Payre, P.; Perrin, P.; Poinsignon, J.; Potheau, R.; Qian, Z.; Raymond, M.; Roberts, J.; Sacquin, Y.; Schuller, J.P; Schuster, W.; Spooner, N.; Stolarczyk, T.; Tabary, A.; Talby, M; Tao, C.; Thompson, L.; Triay, R.; Valdy, M.; Velasco, J.; Vigeolas, E.; Vignaud, D.; Vilanova, D.; Wark, D.; Zuniga, J.

    1999-01-01

    The ANTARES project is an international collaboration with the aim of building a deep-sea large area neutrino telescope within the next decade. The achievements and status of the project as at the time of the conference are briefly discussed, and short term steps as well as longer term plans are described

  12. The Comic Book Project

    Science.gov (United States)

    Bitz, Michael

    2008-01-01

    The Comic Book Project (CBP) celebrates its eighth anniversary this year. The project, which just originated with one school in New York City, had grown to encompass thousands of students nationwide. The goal of the CBP is not to create comics the "Marvel way" or to develop the next Stan Lee. Rather, the goal is to give students the opportunity to…

  13. Project Identification and Formulation

    DEFF Research Database (Denmark)

    Lund, Søren; Lønholdt, Jens

    2005-01-01

    Provides the necessary conceptual framework and tools to assess all appropriate aspects of water and sanitation projects in developing countries. Appeals to graduate environmental engineering students, practitioners, economists, sociologists, and institutional planners working with water...... and sanitation projects in developing countries....

  14. Climate projections FAQ

    Science.gov (United States)

    A.E. Daniels; J.F. Morrison; L.A. Joyce; N.L. Crookston; S.C. Chen; S.G. McNulty

    2012-01-01

    Climate scenarios offer one way to identify and examine the land management challenges posed by climate change. Selecting projections, however, requires careful consideration of the natural resources under study, and where and how they are sensitive to climate. Selection also depends on the robustness of different projections for the resources and geographic area of...

  15. Plant Biology Science Projects.

    Science.gov (United States)

    Hershey, David R.

    This book contains science projects about seed plants that deal with plant physiology, plant ecology, and plant agriculture. Each of the projects includes a step-by-step experiment followed by suggestions for further investigations. Chapters include: (1) "Bean Seed Imbibition"; (2) "Germination Percentages of Different Types of Seeds"; (3)…

  16. Private Water Projects

    OpenAIRE

    Izaguirre, Ada Karina; Hunt, Catherine

    2005-01-01

    Drawing on the World Bank's Private Participation in Infrastructure Project Database, this Note reviews developments in the water and sewerage sector of developing countries in 2004 and changes in private participation in the sector since 2001. Data for 2004 show that total investment in water and sewerage projects with private participation amounted to nearly US$2 billion. Recent private ...

  17. Classifying IS Project Problems

    DEFF Research Database (Denmark)

    Munk-Madsen, Andreas

    2006-01-01

    The literature contains many lists of IS project problems, often in the form of risk factors. The problems sometimes appear unordered and overlapping, which reduces their usefulness to practitioners as well as theoreticians. This paper proposes a list of criteria for formulating project problems...

  18. Creatvity in Project Work

    DEFF Research Database (Denmark)

    Bjørner, Thomas; Kofoed, Lise B.; Bruun-Pedersen, Jon Ram

    2012-01-01

    that they are creative during all stages in the project work. However, it is also significant that the Medialogy students believe that they are more creative in the beginning of their projects and during the design and implementation stages, whereas the analysis is a less creative part. In general, the Medialogy...

  19. Financing landfill gas projects

    International Nuclear Information System (INIS)

    Bull, R.

    1992-01-01

    The problems of financing landfill gas projects in the UK in the last few years are discussed. The approach of the author in setting up a company to finance such projects in the power generation field and a separate company to design and supply turnkey packages is reported. (UK)

  20. The Nordwrite Project.

    Science.gov (United States)

    Evensen, Lars, Sigfred

    A planned 3-year joint project of the Nordic research council for the humanities that focuses on writing development in school-age children is described. Four Nordic countries are involved in the project: Finland, Sweden, Norway, and Denmark. In the study, discourse-level performance analyses of student writing in English as a Second Language are…

  1. The Okapi Projects.

    Science.gov (United States)

    Keen, Michael

    1997-01-01

    Examines general issues in conducting information retrieval research. Topics include the Okapi information retrieval system and its probabilistic model; the Cranfield projects, concerning recall and precision; the SMART project with its vector-space model; evaluation methodology, including laboratory evaluation of interactive systems; and…

  2. The TULIP Project.

    Science.gov (United States)

    Gusack, Nancy, Ed.; And Others

    1995-01-01

    Contains 11 articles that describe different university access systems designed and built to provide access to journals via The University Licensing Program (TULIP), a science journal access project, involving Elsevier Science Publishing and major universities. The project produced insights to help with future electronic information delivery…

  3. Impact of Project Leadership Facets on Project Outcome

    Directory of Open Access Journals (Sweden)

    Arslan Ayub

    2015-08-01

    Full Text Available The study analyzes the role of project leadership facets on effective project outcome. Numerous such initiatives have already been taken on project outcome/performance in the context of apposite leadership styles or project management. However, the current study is unique in the milieu of project outcome that it introduces a new leadership approach, which throws light on the significance of variant leadership facets on project outcome. The study uses explanatory approach; primary data is collected from project management professionals working in different project organizations. The study uses structural equation model (SEM technique to test the hypothesis. The study found a positive relationship between project leadership facets and project outcome.

  4. Solar renovation demonstration projects

    Energy Technology Data Exchange (ETDEWEB)

    Bruun Joergensen, O [ed.

    1998-10-01

    In the framework of the IEA SHC Programme, a Task on building renovation was initiated, `Task 20, Solar Energy in Building Renovation`. In a part of the task, Subtask C `Design of Solar Renovation Projects`, different solar renovation demonstration projects were developed. The objective of Subtask C was to demonstrate the application of advanced solar renovation concepts on real buildings. This report documents 16 different solar renovation demonstration projects including the design processes of the projects. The projects include the renovation of houses, schools, laboratories, and factories. Several solar techniques were used: building integrated solar collectors, glazed balconies, ventilated solar walls, transparent insulation, second skin facades, daylight elements and photovoltaic systems. These techniques are used in several simple as well as more complex system designs. (au)

  5. Strategy as Projects

    DEFF Research Database (Denmark)

    Lund Pedersen, Carsten; Ritter, Thomas; Andersen, Torben Juul

    This paper proposes the adoption of a project-based view to analyze strategy formation and strategic renewal over time. Projects are resource-committing, empirically-tracable investments, and as such, particularly suitable for the analysis of different manifestations of intended strategies as well...... as post-hoc manifestations of deviant, even rebellious, actions taken in opposition to the initial strategy announcement. The paper presents an analytical framework (a 5x2 matrix) of ten different project categories that together allows researchers to investigate how strategic renewal is realized through...... the enactment of different types of project initiatives throughout the organization. The developed framework is validated by two field studies that outline the robustness of the proposed matrix. In addition to the demonstration of the advantages of the framework, we discuss the limitations of the strategy-as-projects...

  6. Project management for engineers

    CERN Document Server

    Bennett, Michael J

    2014-01-01

    Project Management for Engineers, as the title suggests, is a direct attempt at addressing the ever-increasing and specific needs for better project management of engineering students, practicing engineers and managers in the industry. It aims not only to present the principles and techniques of Project Management, but also to discuss project management standards, processes and requirements, such as PMBOK, IEEE and PRINCE. Each chapter begins with the basics of the theme being developed at a level understandable to an undergraduate, before more complex topics are introduced at the end of each section that are suitable for graduate students. For the practicing professionals or managers in the industry, the book also provides many real illustrations of practical application of the principles of Project Management. Through a realistic blend of theory and practical examples, as well as an integration of the engineering technical issues with business issues, this book seeks to remove the veil of mystery that has...

  7. EDUCATIONAL PROJECTS STAKEHOLDER MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Юлія Юріївна ГУСЄВА

    2016-02-01

    Full Text Available An approach based on an integration of requirements breakdown structure and work breakdown structure of the project is proposed. It can complement existing methods of project stakeholders classification with the indicator of resource input, which can be defined in monetary terms. A method of requirements monitoring is proposed, which allows you to track the requirements of project stakeholders over time according to the actual amount of resources spent by analogy with the earned value method. Proposed indexes are the basis not only for monitoring but for the forecast of the project. The need of creating of a mechanism for getting baseline data taking into account the existence of different types of requirements of project stakeholders is grounded.

  8. Distributed Project Work

    DEFF Research Database (Denmark)

    Borch, Ole; Kirkegaard, B.; Knudsen, Morten

    1998-01-01

    for information exchange in the traditional project environment is performed. A group of teachers and a student group using small project examples test the method. The first test group used a prototype for testing and found the new activity synchronization difficult to adapt, so the method was finally adjusted...... to be very precises and with success used on the second test group. Distributed project work is coming pretty soon and with little improvement in server tools, projects in different topics with a large and inhomogeneous profile of users are realistic.......Project work has been used for many years at Aalborg University to improve learning of theory and methods given in courses. In a closed environment where the students are forming a group in a single room, the interaction behaviour is more or less given from the natural life. Group work...

  9. Bioenergy/Biotechnology projects

    Energy Technology Data Exchange (ETDEWEB)

    Napper, Stan [Louisiana Tech Univ., Ruston, LA (United States); Palmer, James [Louisiana Tech Univ., Ruston, LA (United States); Wilson, Chester [Louisiana Tech Univ., Ruston, LA (United States); Guilbeau, Eric [Louisiana Tech Univ., Ruston, LA (United States); Allouche, Erez [Louisiana Tech Univ., Ruston, LA (United States)

    2012-06-30

    This report describes the progress of five different projects. The first is an enzyme immobilization study of cellulase to reduce costs of the cellulosic ethanol process. High reusability and use of substrates applicable to large scale production were focus areas for this study. The second project was the development of nanostructured catalysts for conversion of syngas to diesel. Cobalt nanowire catalyst was used in Fischer-Tropsch synthesis. The third project describes work on developing a microfluidic calorimeter to measure reaction rates of enzymes. The fourth project uses inorganic polymer binders that have the advantage of a lower carbon footprint than Portland cement while also providing excellent performance in elevated temperature, high corrosion resistance, high compressive and tensile strengths, and rapid strength gains. The fifth project investigates the potential of turbines in drop structures (such as sewer lines in tall buildings) to recover energy.

  10. VT Biodiversity Project - Landforms

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) This is a raster (cell-based) dataset depicting landforms in Vermont. Cells are 30 meters. Landforms are topographic units of landscapes that...

  11. Fiscal 1974 Sunshine Project result report. R and D on photovoltaic power generation system (R and D on new type solar cells); 1974 nendo taiyoko hatsuden system no kenkyu kaihatsu seika hokokusho. Shingatashiki taiyo denchi no kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1975-05-27

    This report summarizes the fiscal 1974 research result on R and D of new type solar cells, which includes researches on (1) solar cell structure, (2) packaging, and (3) improvement of a conversion efficiency. In the 1st research, theoretical study was made on the relation between a solar cell efficiency and various design factors to obtain basic data for ordinary cell structure and vertical junction type cell structure. As impurity source, a thermal diffusion method using doped oxide by CVD was compared with that using boron nitride, resulting in no difference in solar cell characteristics between both methods. The measurement results on contact resistances of Al, Fe and Ni with electrodes prepared by electron beam deposition showed that these materials are applicable to Si more than 10{sup 18}/cm{sup 3} in impurity density as electrode materials. In the 2nd research, exposure tests were made on some kinds of specimens, resulting in no troubles. Study was made on production costs and structures suitable for automatic production of 4 kinds of packages with different basic structures. In the 3rd research, the prototype solar cell was prepared to use under solar radiation within 20SUNS. (NEDO)

  12. projecting pARTicles, a STEAM project

    CERN Document Server

    Goldfarb, Steven; The ATLAS collaboration

    2016-01-01

    Agnes Chavez is a media artist based in the US (New Mexico) and involved in STEM Art Labs. An informal partnership initiated with some ATLAS physicists will develop further in 2016 through a series of workshops where Virtual Visits, Master Class material and the presence of a physicist will be gradually integrated. The project can be seen as an illustration of constructive and long term collaboration between artists, students and scientists.

  13. All projects related to Brazil | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    All projects related to Brazil ... Cellular senescence is a programmed response to oncogenic (tumour-causing) stress that aims to halt the expansion of cells ... Tackling online inequality: Making digital platforms work for inclusive development.

  14. BODIES OF KNOWLEDGE IN PROJECT MANAGEMENT AND PROJECT QUALITY MANAGEMENT

    OpenAIRE

    Tamara Gvozdenovic; Mirjana Miljanovic; Aleksandar Jegdic; Zeljko Crnogorcic

    2008-01-01

    One of the main trends is standardization of project management. Some of the most important bodies of knowledge in project management, which were created by professional associations for project management are given in this paper. The main of the project management, apart from minimization of time, resources and costs, is to finish the project in the required quality, i.e. it is very important during the whole process of project management to provide realizing the project without any deviatio...

  15. Projection from the prefrontal cortex to histaminergic cell groups in the posterior hypothalamic region of the rat. Anterograde tracing with Phaseolus vulgaris leucoagglutinin combined with immunocytochemistry of histidine decarboxylase

    NARCIS (Netherlands)

    Wouterlood, F.G.; Steinbusch, H.W.M.; Luiten, P.G.M.; Bol, J.G.J.M.

    1987-01-01

    We investigated the projection from the infralimbic division of the prefrontal cortex (area 25) to histaminergic neurons in the posterior hypothalamic area. Phaseolus vulgaris-leucoagglutinin (PHA-L) was injected in the prefrontal cortex of rats. Frozen brain sections were subjected to combined

  16. Financing of Chamera project

    International Nuclear Information System (INIS)

    Jain, A.K.; Chakraborty, D.K.

    1994-01-01

    Chamera Hydroelectric Project was selected by National Hydroelectric Power Corporation (NHPC) as a pilot project for accelerated development of hydro-power in the country. This project was considered to have certain distinct specialties from different aspects in comparison with other projects. In the first place, the field investigation for the project was completed in a record time of only eight months by deploying the most modern techniques. Secondly, Chamera was the first NHPC project with external aid both technically and financially. The third and most important of all the specialties was in the planned reduction of construction period to 6 years from the original estimate of 8 years. Such reduction of gestation period was considered to be the direct outcome of modern method of management, monitoring and improved imported technology. The investment decision in the project was taken in April '84 with an estimated cost of energy at busbar 44.12 paise/unit exclusive of return on equity capital and royalty payable to the home state. The all inclusive rate of power was estimated 75.86 paise/unit. (author). 4 tabs

  17. Improving Project Manufacturing Coordination

    Directory of Open Access Journals (Sweden)

    Korpivaara Ville

    2014-09-01

    Full Text Available The objective of this research is to develop firms’ project manufacturing coordination. The development will be made by centralizing the manufacturing information flows in one system. To be able to centralize information, a deep user need assessment is required. After user needs have been identified, the existing system will be developed to match these needs. The theoretical background is achieved through exploring the literature of project manufacturing, development project success factors and different frameworks and tools for development project execution. The focus of this research is rather in customer need assessment than in system’s technical expertise. To ensure the deep understanding of customer needs this study is executed by action research method. As a result of this research the information system for project manufacturing coordination was developed to respond revealed needs of the stakeholders. The new system improves the quality of the manufacturing information, eliminates waste in manufacturing coordination processes and offers a better visibility to the project manufacturing. Hence it provides a solid base for the further development of project manufacturing.

  18. Projected coupled cluster theory.

    Science.gov (United States)

    Qiu, Yiheng; Henderson, Thomas M; Zhao, Jinmo; Scuseria, Gustavo E

    2017-08-14

    Coupled cluster theory is the method of choice for weakly correlated systems. But in the strongly correlated regime, it faces a symmetry dilemma, where it either completely fails to describe the system or has to artificially break certain symmetries. On the other hand, projected Hartree-Fock theory captures the essential physics of many kinds of strong correlations via symmetry breaking and restoration. In this work, we combine and try to retain the merits of these two methods by applying symmetry projection to broken symmetry coupled cluster wave functions. The non-orthogonal nature of states resulting from the application of symmetry projection operators furnishes particle-hole excitations to all orders, thus creating an obstacle for the exact evaluation of overlaps. Here we provide a solution via a disentanglement framework theory that can be approximated rigorously and systematically. Results of projected coupled cluster theory are presented for molecules and the Hubbard model, showing that spin projection significantly improves unrestricted coupled cluster theory while restoring good quantum numbers. The energy of projected coupled cluster theory reduces to the unprojected one in the thermodynamic limit, albeit at a much slower rate than projected Hartree-Fock.

  19. RCA's regional industrial project

    International Nuclear Information System (INIS)

    Ali, A.T.

    1988-01-01

    The Regional Cooperation Agreement (RCA) for Research Development and Training Related to Nuclear Science and Technology, formulated under the auspices of the International Atomic Energy Agency (IAEA), came into force in June 1972. The overall objective of RCA is to promote technical cooperation among the developing and developed countries in the Asia Pacific region in the peaceful uses of nuclear energy and related technology. Currently, the biggest project under RCA is the Regional Project on the Industrial Applications of Isotopes and Radiation Technology for Asia and the Pacific. The project was established in 1982 for a period of five years and was completed in December 1986. The first phase of the project has generated a high degree of awareness on the industrial potential of isotopes and radiation technology throughout the region; produced a cadre of trained manpower in all areas covered by the project; identified the expertise available in the region; and developed in the region, a unique network of people and institutions involved with the utilization of isotope and radiation technology. A Phase II of the project, which cover all but one of the sub-projects under Phase I, was approved in early 1987 for another five years until 1991. (Nogami, K.)

  20. New Accelerator Projects

    International Nuclear Information System (INIS)

    Delahaye, J.P.

    2010-01-01

    There is large number of ambitious accelerator projects with promising performances in the near (and short term) future which aims at exploring energy and/or luminosity frontiers and Complementary aspects of various particles species. High Energy Physics requirements are extremely demanding with challenging parameters: entering into the new territories of the tera-scale data, high Energy or/and High (Integrated) Luminosity, high performance, high availability, long lifetime, luminosity leveling etc.. New projects are more and more challenging: larger, more powerful, more expensive, technology above present standard. Innovative ideas and breakthrough on novel technologies are key for HEP adventure. Aggressive R and D is imperative on beam and Technology related, on cost and power consumption mitigation.. There is ambitious Test Facilities to address feasibility. More and more time and (M and P) resources are required from first ideas to project proposal: it is of prime importance to launch R and D early, explore all possible options of schemes and technologies (anticipating future Physics requests), make realistic status and schedule estimates (preserve credibility and make reasonable plans). Global Collaboration is mandatory from the R and D phase to the construction and operation in order to make best use of limited resources and available expertise as inspired from successful collaborations on Detectors. The global strategy of new accelerator projects in truly world-wide collaboration aims at: - defining all various Projects and Technology options worth exploring, - taking advantage of global teams made of world-wide experts, and of synergies to address common issues (generic R and D) of various projects, - preparing together plethora of project proposals to cover Physics Landscape (ready for window opportunity), - developing Collaborative/Competition (Experts in Collaboration, Technology and Projects options in Competition), - Joining resources on (few) selected

  1. Freedom and Responsibility in Synthetic Genomics: The Synthetic Yeast Project

    OpenAIRE

    Sliva, Anna; Yang, Huanming; Boeke, Jef D.; Mathews, Debra J. H.

    2015-01-01

    First introduced in 2011, the Synthetic Yeast Genome (Sc2.0) Project is a large international synthetic genomics project that will culminate in the first eukaryotic cell (Saccharomyces cerevisiae) with a fully synthetic genome. With collaborators from across the globe and from a range of institutions spanning from do-it-yourself biology (DIYbio) to commercial enterprises, it is important that all scientists working on this project are cognizant of the ethical and policy issues associated with...

  2. The Project of Success

    DEFF Research Database (Denmark)

    Kreiner, Kristian

    more complicated matter than meeting targets. While success may ultimately be justified in terms of a correspondence between aims and achievements, the understanding of both aspects is highly dependent on the project process. An example of a successful project that did not meet the original performance...... targets will serve to show that success is at matter of perspective as much as it is a matter of achievement. Other types of research, e.g. social psychology, have addressed the issue of success more explicitly. I draw on such literature to conceptualize project success anew and to reestablish...

  3. IT Project Prioritization Process

    DEFF Research Database (Denmark)

    Shollo, Arisa; Constantiou, Ioanna

    2013-01-01

    In most of the large companies IT project prioritization process is designed based on principles of evidencebased management. We investigate a case of IT project prioritization in a financial institution, and in particular, how managers practice evidence-based management during this process. We use...... a rich dataset built from a longitudinal study of the prioritization process for the IT projects. Our findings indicate that managers reach a decision not only by using evidence but from the interplay between the evidence and the judgment devices that managers employ. The interplay between evidence...

  4. Raspberry Pi projects

    CERN Document Server

    Robinson, Andrew

    2013-01-01

    Learn to build software and hardware projects featuring the Raspberry Pi! Raspberry Pi represents a new generation of computers that encourages the user to play and to learn and this unique book is aimed at the beginner Raspberry Pi user who is eager to get started creating real-world projects. Taking you on a journey of creating 15 practical projects, this fun and informative resource introduces you to the skills you need to have in order to make the most of the Pi. The book begins with a quick look at how to get the Pi up and running and then encourages you to dive into the array of exciti

  5. The CORMAN project

    DEFF Research Database (Denmark)

    Bregnballe, Thomas

    2013-01-01

    The CORMAN project (‘Sustainable Management of Cormorant Populations’) is now in its final year. The main goals have been (1) to collaborate with the CRG in order to assess the number and distribution of Cormorants in Europe during breeding and wintertime, and (2) to create the EU Cormorant...... Platform in order to disseminate information. The project has also engaged with key European stakeholder groups and formed a Stakeholders Liaison Group to support information exchange and discuss relevant issues. The project is carried out on behalf of DG Environment under the European Commission....

  6. Making energy projects happen

    International Nuclear Information System (INIS)

    Gilliland, S.F.; Utt, W.P.; Neff, N.T.

    1988-01-01

    In today's business environment, control of energy cost is a major challenge for businesses, institutions, and governmental agencies. New technologies are available to reduce energy costs through cogeneration, cheaper fuels, or other means. Often it is not possible for a Plant Owner to undertake such a project, regardless of how desirable it may be. The authors of this paper show that by applying the principles of Project Structuring and developing a comprehensive project team, the desired reduction in energy costs can be achieved. Various examples are cited, and guidelines are given for an Owner to use

  7. Status of APE projects

    CERN Document Server

    Alfieri, R; Onofri, E; Bartoloni, A; Battista, C; Cabibbo, Nicola; Cosimi, M; Lonardo, A; Michelotti, A; Proietti, B; Rapuano, F; Rossetti, D; Sacco, G; Tassa, S; Torelli, M; Vicini, P; Pène, O; Errico, W; Magazzù, G; Sartori, L; Schiiano, F; Tripiccione, R; De Riso, P; Petronzio, Roberto; Destri, C; Frezzotti, R; Marchesini, G; Gensch, Ulrich; Jansen, K; Kretzschmann, A; Leich, H; Paschedag, N; Pleiter, D; Schwendicke, U; Simma, H; Sommer, Rainer; Sulanke, K; Wegner, P; Fucci, A; Martin, B; Pech, J; Panizzi, E; Petricola, A

    2001-01-01

    This talk is divided in two parts. In the first part, we will summarize the status of the APEmille project that will be completed by the end of the year. We will then devote the rest of the talk to the description of a new project for a multi-TeraFlop machine, ape NEXT. The interested reader will find a much more detailed discussion of all the items touched upon here in the full proposal of the project that will shortly appear on hep-lat. (9 refs).

  8. WFIRST Project Science Activities

    Science.gov (United States)

    Gehrels, Neil

    2012-01-01

    The WFIRST Project is a joint effort between GSFC and JPL. The project scientists and engineers are working with the community Science Definition Team to define the requirements and initial design of the mission. The objective is to design an observatory that meets the WFIRST science goals of the Astr02010 Decadal Survey for minimum cost. This talk will be a report of recent project activities including requirements flowdown, detector array development, science simulations, mission costing and science outreach. Details of the interim mission design relevant to scientific capabilities will be presented.

  9. Arduino projects for dummies

    CERN Document Server

    Craft, Brock

    2013-01-01

    Discover all the amazing things you can do with Arduino Arduino is a programmable circuit board that is being used by everyone from scientists, programmers, and hardware hackers to artists, designers, hobbyists, and engineers in order to add interactivity to objects and projects and experiment with programming and electronics. This easy-to-understand book is an ideal place to start if you are interested in learning more about Arduino's vast capabilities. Featuring an array of cool projects, this Arduino beginner guide walks you through every step of each of the featured projects so

  10. Adaptive projective filters

    International Nuclear Information System (INIS)

    Dikusar, N.D.

    1993-01-01

    The new approach to solving of the finding problem is proposed. The method is based on Discrete Projective Transformations (DPT), the List Square Fitting (LSF) and uses the information feedback in tracing for linear or quadratic track segments (TS). The fast and stable with respect to measurement errors and background points recurrent algorithm is suggested. The algorithm realizes the family of digital adaptive projective filters (APF) with known nonlinear weight functions-projective invariants. APF can be used in adequate control systems for collection, processing and compression of data, including tracking problems for the wide class of detectors. 10 refs.; 9 figs

  11. 3D Projection Installations

    DEFF Research Database (Denmark)

    Halskov, Kim; Johansen, Stine Liv; Bach Mikkelsen, Michelle

    2014-01-01

    Three-dimensional projection installations are particular kinds of augmented spaces in which a digital 3-D model is projected onto a physical three-dimensional object, thereby fusing the digital content and the physical object. Based on interaction design research and media studies, this article ...... Fingerplan to Loop City, is a 3-D projection installation presenting the history and future of city planning for the Copenhagen area in Denmark. The installation was presented as part of the 12th Architecture Biennale in Venice in 2010....

  12. Baltic nuclear projects

    International Nuclear Information System (INIS)

    Adlys, Gediminas; Adliene, Diana

    2009-01-01

    The Authors discuss the Baltic energy policy with respect to new nuclear power plants for Lithuania, Belarus and the Kaliningrad region. The construction of a new nuclear power plant in Lithuania would threaten Russian interests in the region. Therefore Lithuania is looking to Russian plans to build a new nuclear power plant in the Kaliningrad region as an attempt to subvert Lithuania's foreign partners and potential investors from participating in the Visaginas NPP project. However, the authors conclude, that the Visaginas NPP project is and must be the preferential project for the EU and NATO member states.

  13. The VIRGO project

    International Nuclear Information System (INIS)

    Yvert, M.

    1991-01-01

    The detection of gravitational waves is, nowadays, technologically possible. The Virgo project, proposed by a French-Italian collaboration, is now on the verge of being fully approved and funded. The goal of the Virgo project is, first, to detect gravitational waves. The next will be to perform, in conjunction with other similar detectors, more precise measurements (i.e. the spin of the graviton) and start gravitational wave astrophysical observations. The method is proposed to use a large Michelson interferometer as a detector. The main motivations, characteristics and expected sensitivity of this project are described. (R.P.) 14 refs., 6 figs

  14. One project`s waste is another project`s resource

    Energy Technology Data Exchange (ETDEWEB)

    Short, J.

    1997-02-01

    The author describes the efforts being made toward pollution prevention within the DOE complex, as a way to reduce overall project costs, in addition to decreasing the amount of waste to be handled. Pollution prevention is a concept which is trying to be ingrained into project planning. Part of the program involves the concept that ultimately the responsibility for waste comes back to the generator. Parts of the program involve efforts to reuse materials and equipment on new projects, to recycle wastes to generate offsetting revenue, and to increase awareness, accountability and incentives so as to stimulate action on this plan. Summaries of examples are presented in tables.

  15. Leading global projects for professional and accidental project leaders

    CERN Document Server

    Moran, Robert T

    2008-01-01

    This book is a must-read for anyone responsible for projects and initiatives that span functional and geographical divides. Authors Moran and Youngdahl bring extensive experience and learning from industry practice to present a clear and straightforward treatment of the leadership skills and knowledge required to lead projects that are global in nature. They have written the first book of its kind to address the three essential skills of global project leaders - strategic project management, project leadership, and cross-cultural leadership. The authors argue that global project leadership is an essential skill in our project-based world and that we are all either intentional or accidental project leaders. Intentional project leaders pursue formal project management education and even certification whereas accidental project leaders find themselves leading global projects and initiatives as a result of a special assignment or promotion. Moran and Youndahl have found that the vast majority of global projects ...

  16. The application of project management in construction projects ...

    African Journals Online (AJOL)

    Project management is critical for successful project development. A crucial responsibility of the project manager is ensuring that the client is certified and the scope of work is of high quality, within the agreed budget and time frame. In some way, project financing is completed from the time of project conception. Indeed ...

  17. Organization of BSc and MSc projects in project families

    DEFF Research Database (Denmark)

    Ottosen, Lisbeth M.; Goltermann, Per; Jensen, Pernille Erland

    2014-01-01

    This work reports organization of student thesis projects in project families, with the benefit to both teaching and learning. The project organization went from student projects broadly distributed on topics related to different research issues and individual supervision to project families with...

  18. Hilar mossy cell circuitry controlling dentate granule cell excitability

    Directory of Open Access Journals (Sweden)

    Seiichiro eJinde

    2013-02-01

    Full Text Available Glutamatergic hilar mossy cells of the dentate gyrus can either excite or inhibit distant granule cells, depending on whether their direct excitatory projections to granule cells or their projections to local inhibitory interneurons dominate. However, it remains controversial whether the net effect of mossy cell loss is granule cell excitation or inhibition. Clarifying this controversy has particular relevance to temporal lobe epilepsy, which is marked by dentate granule cell hyperexcitability and extensive loss of dentate hilar mossy cells. Two diametrically opposed hypotheses have been advanced to explain this granule cell hyperexcitability – the dormant basket cell and the irritable mossy cell hypotheses. The dormant basket cell hypothesis proposes that mossy cells normally exert a net inhibitory effect on granule cells and therefore their loss causes dentate granule cell hyperexcitability. The irritable mossy cell hypothesis takes the opposite view that mossy cells normally excite granule cells and that the surviving mossy cells in epilepsy increase their activity, causing granule cell excitation. The inability to eliminate mossy cells selectively has made it difficult to test these two opposing hypotheses. To this end, we developed a transgenic toxin-mediated, mossy cell-ablation mouse line. Using these mutants, we demonstrated that the extensive elimination of hilar mossy cells causes granule cell hyperexcitability, although the mossy cell loss observed appeared insufficient to cause clinical epilepsy. In this review, we focus on this topic and also suggest that different interneuron populations may mediate mossy cell-induced translamellar lateral inhibition and intralamellar recurrent inhibition. These unique local circuits in the dentate hilar region may be centrally involved in the functional organization of the dentate gyrus.

  19. Information on Stem Cell Research

    Science.gov (United States)

    ... Home » Current Research » Focus on Research Focus on Stem Cell Research Stem cells possess the unique ability to differentiate into ... virus infection. To search the complete list of stem cell research projects funded by NIH please go to NIH ...

  20. Innovations in redevelopment projects

    Directory of Open Access Journals (Sweden)

    Radushinsky Dmitry

    2018-01-01

    Full Text Available Some examples of redevelopment of industrial territories (lofting abroad and in Russia for the purpose of qualitative research and classification, identification of the main features of process innovations are considered in the article. The following main parameters were established, according to which the differences in the implementation of various types of redevelopment projects were determined: the composition of the consumers of the services (the result of the implemented project, the opportunities and the intensity of the flow of high-class specialists to the jobs created during the redevelopment of municipal and regional facilities, area, value (budget and terms of project implementation. A perspective project of RTOs (museum-entertainment complex for machine-building in Kolpino, as well as opportunities to expand the ecosystem of innovation Sochi Innovation Valley, was considered.