The 150 Credit-Hour Requirement and CPA Examination Pass Rates--A Four Year Study

Science.gov (United States)

Briggs, Gary P.; He, Lerong

2012-01-01

Debate concerning the minimum educational requirements of certified public accountant (CPA) candidates in the USA has been taking place for decades. This paper compares the sectional pass rates of CPA candidates from jurisdictions requiring 150 credit hours of college study with the pass rates of candidates from jurisdictions not requiring 150…

Formulation development of the biocontrol agent Bacillus subtilis strain CPA-8 by spray-drying.

Science.gov (United States)

Yánez-Mendizábal, V; Viñas, I; Usall, J; Torres, R; Solsona, C; Abadias, M; Teixidó, N

2012-05-01

To prepare commercially acceptable formulations of Bacillus subtilis CPA-8 by spray-drying with long storage life and retained efficacy to control peach and nectarine brown rot caused by Monilinia spp. CPA-8 24-h- and 72-h-old cultures were spray dried using 10% skimmed milk, 10% skimmed milk plus 10% MgSO(4) , 10% MgSO(4) and 20% MgSO(4) as carriers/protectants. All carriers/protectants gave good percentages of powder recovery (28-38%) and moisture content (7-13%). CPA-8 survival varied considerably among spray-dried 24-h- and 72-h-old cultures. Seventy-two hours culture spray dried formulations showed the highest survival (28-32%) with final concentration products of 1·6-3·3 × 10(9) CFU g(-1) , while viability of 24-h-old formulations was lower than 1%. Spray-dried 72-h-old formulations were selected to subsequent evaluation. Rehydration of cells with water provided a good recovery of CPA-8 dried cells, similar to other complex rehydration media tested. Spray-dried formulations stored at 4 ± 1 and 20 ± 1°C showed good shelf life during 6 months, and viability was maintained or slightly decreased by 0·2-0·3-log. CPA-8 formulations after 4- and 6 months storage were effective in controlling brown rot caused by Monilinia spp. on nectarines and peaches resulting in a 90-100% reduction in disease incidence. Stable and effective formulations of biocontrol agent B. subtilis CPA-8 could be obtained by spray-drying. New shelf-stable and effective formulations of a biocontrol agent have been obtained by spray-drying to control brown rot on peach. © 2012 The Authors. Journal of Applied Microbiology © 2012 The Society for Applied Microbiology.

Development of an Electrolyte CPA Equation of state for Applications in the Petroleum and Chemical Industries

DEFF Research Database (Denmark)

Maribo-Mogensen, Bjørn

to the CPA EoS in the absence of electrolytes, making it possible to extend the applicability of the CPA EoS while retaining backwards compatibility and resuing the parameters for non-electrolyte systems . There are many challenges related to thermodynamic modeling of mixtures containing electrolytes......This thesis extends the Cubic Plus Association (CPA) equation of state (EoS) to handle mixtures containing ions from fully dissociated salts. The CPA EoS has during the past 18 years been applied to thermodynamic modeling of a wide range of industrially important chemicals, mainly in relation...... rarely been applied to all types of thermodynamic equilibrium calculations relevant to electrolyte solutions. This project has aimed to determine the best recipe to deliver a complete thermodynamic model capable of handling electrolytes in mixed solvents and at a wide range of temperature and pressure...

The CPA Exam as a Postcurriculum Accreditation Assessment

Science.gov (United States)

Barilla, Anthony G.; Jackson, Robert E.; Mooney, J. Lowell

2008-01-01

Business schools often attain accreditation to demonstrate program efficacy. J. A. Marts, J. D. Baker, and J. M. Garris (1988) hypothesized that candidates from Association to Advance Collegiate Schools of Business International (AACSB)-accredited accounting programs perform better on the CPA exam than do candidates from non-AACSB-accredited…

Process Design of Industrial Triethylene Glycol Processes Using the Cubic-Plus-Association (CPA) Equation of State

DEFF Research Database (Denmark)

Arya, Alay; Maribo-Mogensen, Bjørn; Tsivintzelis, Ioannis

2014-01-01

The Cubic-Plus-Association (CPA) equation of state (EoS) has already been proven to be a successful model for phase equilibrium calculations for systems containing glycols. In the present work, we interface a thermodynamic property package (Thermo System), based on CPA, with Aspen HYSYS through...

Protection of neuroblastoma Neuro2A cells from hypoxia-induced apoptosis by cyclic phosphatidic acid (cPA.

Directory of Open Access Journals (Sweden)

Mari Gotoh

Full Text Available Cyclic phosphatidic acid (cPA is a naturally occurring phospholipid mediator with a unique cyclic phosphate ring at the sn-2 and sn-3 positions of its glycerol backbone. We have previously shown that cPA significantly suppresses ischemia-induced delayed neuronal death and the accumulation of glial fibrillary acidic protein in the CA1 region of the rat hippocampus. These results indicated that the systemic administration of cPA can protect hippocampal neurons against ischemia-induced delayed neuronal cell death. In the current study, we investigated the effects of cPA on neuronal cell death caused by hypoxia in vitro and the molecular mechanisms underlying these effects. We used cobalt chloride (CoCl(2 to expose cells to hypoxic conditions in vitro. Treating mouse neuroblastoma (Neuro2A cells with CoCl(2 induced nuclear DNA condensation and phosphatidylserine exposure. However, adding cPA led to the suppression of CoCl(2-induced apoptosis in a cPA dose-dependent manner and attenuated the increase in the Bax/Bcl-2 ratio caused by CoCl(2. Quantitative PCR analysis showed that Neuro2A cells strongly express the LPA(1, LPA(2, and LPA(6, which are G-protein coupled receptors that can be activated by cPA. To date, LPA(1 and LPA(2 have been reported to exhibit antiapoptotic activity. Therefore, to assess the roles of LPA(1 and LPA(2 on cPA-induced neuroprotective functions, Ki16425, a selective LPA(1 and LPA(3 antagonist, was adopted to know the LPA(1 function and siRNA was used to knockdown the expression of LPA(2. On the basis of our results, we propose that cPA-induced protection of Neuro2A cells from CoCl(2-induced hypoxia damage is mediated via LPA(2.

Distribution of MEG and methanol in well-defined hydrocarbon and water systems: Experimental measurement and modeling using the CPA EoS

DEFF Research Database (Denmark)

Riaz, Muhammad; Yussuf, Mustafe A.; Kontogeorgis, Georgios

2013-01-01

+ water. These data are satisfactorily correlated (binaries) and predicted (ternaries) using Cubic Plus Association (CPA) equation of state (EoS). CPA is also applied to binary LLE of aromatic hydrocarbon + water and VLE of methane + methanol. Finally the distribution of water and inhibitors (methanol...... and MEG) in various phases is modeled using CPA. The hydrocarbon phase consists of mixture-1 (methane, ethane, n-butane) or mixture-2 (methane, ethane, propane, n-butane, n-heptane, toluene and n-decane). CPA can satisfactorily predict the water content in the gas phase of the multicomponent systems...

Fast numerical solution of KKR-CPA equations: Testing new algorithms

Energy Technology Data Exchange (ETDEWEB)

Bruno, E.; Florio, G.M.; Ginatempo, B.; Giuliano, E.S. (Universita di Messina (Italy))

1994-04-01

Some numerical methods for the solution of KKR-CPA equations are discussed and tested. New, efficient, computational algorithms are proposed, allowing a remarkable reduction of computing time and a good reliability in evaluating spectral quantities. 16 refs., 7 figs.

Modeling of phase equilibria with CPA using the homomorph approach

DEFF Research Database (Denmark)

Breil, Martin Peter; Tsivintzelis, Ioannis; Kontogeorgis, Georgios

2011-01-01

For association models, like CPA and SAFT, a classical approach is often used for estimating pure-compound and mixture parameters. According to this approach, the pure-compound parameters are estimated from vapor pressure and liquid density data. Then, the binary interaction parameters, kij, are ...

7 CFR 1773.20 - CPA's submission of the auditor's report, report on compliance, report on compliance and on...

Science.gov (United States)

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false CPA's submission of the auditor's report, report on... for the Submission and Review of the Auditor's Report, Report on Compliance and on Internal Control Over Financial Reporting, and Management Letter § 1773.20 CPA's submission of the auditor's report...

The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms.

Science.gov (United States)

Vidal, Jorge E; Shak, Joshua R; Canizalez-Roman, Adrian

2015-06-01

Clostridium perfringens strains produce severe diseases, including myonecrosis and enteritis necroticans, in humans and animals. Diseases are mediated by the production of potent toxins that often damage the site of infection, e.g., skin epithelium during myonecrosis. In planktonic cultures, the regulation of important toxins, such as CPA, CPB, and PFO, is controlled by the C. perfringens Agr-like (CpAL) quorum sensing (QS) system. Strains also encode a functional LuxS/AI-2 system. Although C. perfringens strains form biofilm-like structures, the regulation of biofilm formation is poorly understood. Therefore, our studies investigated the role of CpAL and LuxS/AI-2 QS systems and of QS-regulated factors in controlling the formation of biofilms. We first demonstrate that biofilm production by reference strains differs depending on the culture medium. Increased biomass correlated with the presence of extracellular DNA in the supernatant, which was released by lysis of a fraction of the biofilm population and planktonic cells. Whereas ΔagrB mutant strains were not able to produce biofilms, a ΔluxS mutant produced wild-type levels. The transcript levels of CpAL-regulated cpa and pfoA genes, but not cpb, were upregulated in biofilms compared to planktonic cultures. Accordingly, Δcpa and ΔpfoA mutants, in type A (S13) or type C (CN3685) backgrounds, were unable to produce biofilms, whereas CN3685Δcpb made wild-type levels. Biofilm formation was restored in complemented Δcpa/cpa and ΔpfoA/pfoA strains. Confocal microscopy studies further detected CPA partially colocalizing with eDNA on the biofilm structure. Thus, CpAL regulates biofilm formation in C. perfringens by increasing levels of certain toxins required to build biofilms. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

The CpAL Quorum Sensing System Regulates Production of Hemolysins CPA and PFO To Build Clostridium perfringens Biofilms

Science.gov (United States)

Shak, Joshua R.; Canizalez-Roman, Adrian

2015-01-01

Clostridium perfringens strains produce severe diseases, including myonecrosis and enteritis necroticans, in humans and animals. Diseases are mediated by the production of potent toxins that often damage the site of infection, e.g., skin epithelium during myonecrosis. In planktonic cultures, the regulation of important toxins, such as CPA, CPB, and PFO, is controlled by the C. perfringens Agr-like (CpAL) quorum sensing (QS) system. Strains also encode a functional LuxS/AI-2 system. Although C. perfringens strains form biofilm-like structures, the regulation of biofilm formation is poorly understood. Therefore, our studies investigated the role of CpAL and LuxS/AI-2 QS systems and of QS-regulated factors in controlling the formation of biofilms. We first demonstrate that biofilm production by reference strains differs depending on the culture medium. Increased biomass correlated with the presence of extracellular DNA in the supernatant, which was released by lysis of a fraction of the biofilm population and planktonic cells. Whereas ΔagrB mutant strains were not able to produce biofilms, a ΔluxS mutant produced wild-type levels. The transcript levels of CpAL-regulated cpa and pfoA genes, but not cpb, were upregulated in biofilms compared to planktonic cultures. Accordingly, Δcpa and ΔpfoA mutants, in type A (S13) or type C (CN3685) backgrounds, were unable to produce biofilms, whereas CN3685Δcpb made wild-type levels. Biofilm formation was restored in complemented Δcpa/cpa and ΔpfoA/pfoA strains. Confocal microscopy studies further detected CPA partially colocalizing with eDNA on the biofilm structure. Thus, CpAL regulates biofilm formation in C. perfringens by increasing levels of certain toxins required to build biofilms. PMID:25824838

Design and performance of a fast thermal response miniature Chromium Potassium Alum (CPA) salt pill for use in a millikelvin cryocooler

Science.gov (United States)

Bartlett, J.; Hardy, G.; Hepburn, I. D.

2015-01-01

The design and performance of a fast thermal response miniature (24 mm outer diameter by 30 mm long) Chromium Potassium Alum (CPA) salt pill is described. The need for a fast thermal response has been driven by the development of a continuously operating millikelvin cryocooler (mKCC) which uses 2 T superconducting magnets that can be ramped to full field in 30 s. The consequence of magnetising and demagnetising the CPA pill in such a short time is that thermal boundary resistance and eddy current heating have a significant impact on the performance of the pill, which was investigated in detail using modelling. The complete design of a prototype CPA pill is described in this paper, including the methods used to minimise thermal boundary resistance and eddy current heating as well as the manufacturing and assembly processes. The performance of the prototype CPA pill operated from a 3.6 K bath is presented, demonstrating that a complete CPA cycle (magnetising, cooling to bath and demagnetising) can be accomplished in under 2.5 min, with magnetisation and demagnetisation taking just 30 s each. The cold finger base temperature of the prototype varies with demagnetisation speed as a consequence of eddy current heating; for a 30 s demagnetisation, a base temperature of 161 mK is obtained, whilst for a 5 min demagnetisation, a base temperature of 149 mK was measured (both from a 3.6 K and 2 T starting position). The measured hold times of the CPA pill at 200 mK, 300 mK, and 1 K are given, proving that the hold time far exceeds the recycle time and demonstrating the potential for continuous operation when two ADRs are used in a tandem configuration. The ease and speed at which the CPA pill temperature can be changed and controlled when stepping between operating temperatures in the range of 200 mK to 4 K using a servo control program is also shown, once again highlighting the excellent thermal response of the pill. All of the test results are in good agreement with the

Modelling the phase equilibria of multicomponent mixtures containing CO₂, alkanes, water, and/or alcohols using the quadrupolar CPA equation of state

DEFF Research Database (Denmark)

Bjørner, Martin Gamel; Kontogeorgis, Georgios

2016-01-01

In this work, a quadrupolar cubic plus association (qCPA) equation of state is evaluated for its ability to predict the phase equilibria of multicomponent mixtures containing CO2 and alkanes, alcohols, and/or water. A single binary interaction parameter is employed in qCPA for all binary combinat...... CPA yields the best results of all the models for the prediction of dew point pressures....

A CPA study of the phonon structure of disordered superlattices

International Nuclear Information System (INIS)

Shijie Xiong; Gendi Pang; Chienhua Tsai.

1985-08-01

The phonon structure of superlattices or modulated alloys with substitutional disorder is studied in the Coherent Phase Approximation (CPA). We consider first the case with diagonal disorder only, by adopting a virtual crystal approximation for the force constants. Then we treat the more complicated case with inclusion of off-diagonal disorder. Numerical examples are also studied in both cases. (author)

Comparison of the SRK and CPA equations of state for physical properties of water and methanol

DEFF Research Database (Denmark)

Lundstrøm, Carsten; Michelsen, Michael Locht; Kontogeorgis, Georgios

2006-01-01

produced together with water, properties of water and additives like methanol and glycol is another target area. Being more polar than hydrocarbons, water, alcohols and glycols may require more advanced models for example an association model like CPA (CubicPlus-Association). This type of model has...... previously been found to be well suited for phase equilibrium calculations on mixtures of hydrocarbons and polar compounds. In this work, SRK (with and without Peneloux volume correction) and CPA are compared for pure water, pure methanol and water-methanol binary mixtures with the purpose of evaluating...

Structure Features and Anti-Gastric Ulcer Effects of Inulin-Type Fructan CP-A from the Roots of Codonopsis pilosula (Franch.) Nannf.

Science.gov (United States)

Li, Jiankuan; Wang, Tao; Zhu, Zhichuan; Yang, Fengrong; Cao, Lingya; Gao, Jianping

2017-12-18

Radix Codonopsis has been used in traditional Chinese medicine for strengthening the immune system, improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis and so on. In the present study, an inulin-type fructan CP-A was obtained from the roots of Codonopsis pilosula (Franch.) Nannf. and its structure was confirmed by MS and NMR as (2 → 1) linked-β-d-fructofuranose. The protective effects of CP-A against ethanol-induced acute gastric ulcer in rats were intensively investigated. A Lacy assay demonstrated that CP-A-treated group (50 mg/kg) showed the gastric damage level 1, which was similar to the positive control group, while the model group exhibited the gastric damage level 3. The Guth assay demonstrated that the mucosa ulcer index for CP-A groups at the doses of 50 mg/kg and 25 mg/kg significantly decreased compared with that in the model group ( p CP-A significantly increased the activities of SOD and GSH-Px, and decreased the contents of MDA and NO, and the activity of MPO in gastric tissue in a dose-dependent manner ( p CP-A were likely the potential component in Radix Codonopsis for treatment of acute gastric ulcers.

Implementing Assessment Engineering in the Uniform Certified Public Accountant (CPA) Examination

Science.gov (United States)

Burke, Matthew; Devore, Richard; Stopek, Josh

2013-01-01

This paper describes efforts to bring principled assessment design to a large-scale, high-stakes licensure examination by employing the frameworks of Assessment Engineering (AE), the Revised Bloom's Taxonomy (RBT), and Cognitive Task Analysis (CTA). The Uniform CPA Examination is practice-oriented and focuses on the skills of accounting. In…

Extension of the cubic-plus-association (CPA) equation of state to amines

DEFF Research Database (Denmark)

Kaarsholm, Mads Kristian; Derawi, Samer; Michelsen, Michael Locht

2005-01-01

The cubic-plus-association (CPA) equation of state has been extended to modeling mixtures containing amines. Special focus was given to primary and secondary amines, which are known to self-associate, thus forming hydrogen bonds in mixtures with alkanes. Pure-compound parameters have been determi...

100 TW CPA Nd: Glass laser for fast ignition research

International Nuclear Information System (INIS)

Fujita, H.; Daido, H.; Jitsuno, T.

2001-01-01

A 100 TW chirped pulse amplification (CPA) Nd:glass laser has been developed to investigate the fast ignition concept. The ultrashort-pulse (60 TW, 42 J, 0.7 ps) was focused on plane targets, plane targets with preformed plasma, and high density compressed plasmas produced by the GEKKO-XII (12 beam, 20 kJ) laser. Focus intensity of >10 19 W/cm 2 has been achieved. (author)

Comparative performance of Aspergillus galactomannan ELISA and PCR in sputum from patients with ABPA and CPA.

Science.gov (United States)

Fayemiwo, Samuel; Moore, Caroline B; Foden, Philip; Denning, David W; Richardson, Malcolm D

2017-09-01

Galactomannan (GM) and Aspergillus DNA detection are useful tools for the diagnosis of invasive pulmonary aspergillosis (IPA), primarily in blood and bronchoscopy samples. This study aimed to evaluate the utility of both markers for detection of Aspergillus in sputum from patients with allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA). ABPA or CPA demographic patient data were retrieved. This retrospective observational audit included 159 patients with at least one sputum pair. 223 sputum sample pairs were analysed, as well as six control samples for GM only. Real time PCR was performed following sputum DNA extraction using the MycAssay™ Aspergillus kit and cycle thresholds were subtracted from 38 to give positive values (transformed Ct, TCt). The mean age of the patients was 61.81years (SD: ±11.06; range 29-100). One hundred and twenty-six (79.2%) had CPA. Cultures were positive for fungi in 13.1% of the samples, and A. fumigatus was the commonest (11.9%) fungus isolated. Receiver operating characteristic (ROC curve) analysis of sputum GM comparing TCt of >0.0, and >2.0 to derive GMI cut-off values showed a cut-off of 6.5. About 50% of sputa with strongly positive PCR values had GM values>6.5. Two of six (33%) control samples had GM indices>6.5. It is not clear that GM determinations in sputum are useful for diagnosis of either CPA or ABPA, or following therapy. Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.

Comprehension-Driven Program Analysis (CPA) for Malware Detection in Android Phones

Science.gov (United States)

2015-07-01

Android source . 3.1.2.2 Analyzers An analyzer conforms to specifications defined by the Security Toolbox. Specifically an analyzer encapsulates a...COMPREHENSION-DRIVEN PROGRAM ANALYSIS (CPA) FOR MALWARE DETECTION IN ANDROID PHONES IOWA STATE UNIVERSITY JULY 2015 FINAL...average 1 hour per response, including the time for reviewing instructions, searching existing data sources , gathering and maintaining the data needed

Establishment of A Novel Chinese Human Lung Adenocarcinoma Cell Line CPA-Yang3 and Its Real Bone Metastasis Clone CPA-Yang3BM in Immunodeficient Mice

Directory of Open Access Journals (Sweden)

Shunfang YANG

2011-02-01

Full Text Available Background and objective The recurrence and metastasis of lung cancer is a tough problem worldwide. The aim of this study is to establish a novel Chinese lung adenocarcinoma cell line and its real bone-seeking clone sub-line for exploring the molecular mechanism of lung cancer metastasis. Methods The cells came from the pleural effusion of a sixtyfive years old female patient with lung adenocarcinoma and supraclavicular lymph node metastases. The gene expression was detected by real-time quantitative PCR. Intracardiac injection of the cells into nude mice was performed and in vivo imaging was obtained by bone scintigraphy and conventional radiography. Bone metastases were determined on bone scintigraphy and then the lesions were resected under deep anesthesia for bone metastasis cancer cell culture. The process was repeated for four cycles to obtain a real bone-seeking clone. Results The tumorigenesis rate started at 4th passage in immunodeficient mice via subcutaneously and as well as later passages. Approximately 1×106 cancer cells were injected into left cardiac ventricle of immunodeficient mice resulted bone metastasis sites were successfully revealed by bone scintigraphy and pathological diagnosis, the mandible (100%, scapula (33%, humerus (50%, vertebral column (50%, femur (66.7% and accompanied invasion with other organs, the adrenal gland (17%, pulmonary (33%, liver (50%, submaxillary gland (33% in the mice after inoculation two-three weeks. The chromosome karyotype analysis of the cells was subdiploid. Quantitative real-time PCR was used to examined and compared with SPC-A-1 lung adenocarcinoma, ESM1, VEGF-C, IL-6, IL-8, AR, SVIL, FN1 genes were overexpress. The novel cell was named CPA-Yang3. The femur metastasis cell was repeated in vivo-in vitro-in vivo with three cycles and harvested a real bone metastasis clone. It was named CPA-Yang3BM. Conclusion Tne characteristics of novel strain CPAYang3 is a highly metastasis cell line of

Assessment of ASTEC-CPA pool scrubbing models against POSEIDON-II and SGTR-ARTIST data

International Nuclear Information System (INIS)

Herranz, Luis E.; Fontanet, Joan

2009-01-01

Aerosol scrubbing in pools mitigates the potential source term in key severe accident scenarios in PWRs and BWRs. Even though models were extensively validated in the past, a thorough and systematic validation under key challenging conditions is missing. Some of those conditions are high injection velocity, high pool temperature and/or presence of submerged structures. In particular, in-code models have been neither updated nor validated based on the most recent experimental data. The POSEIDON-II and the SGTR-ARTIST projects produced sets of data under conditions of utmost interest for pool scrubbing validation: high temperature and submerged structures. This paper investigates the response of models encapsulated in the CPA module of the ASTEC code in the simulation of those experimental set-ups. The influence of key pool scrubbing variables like steam fraction, water depth, gas flow-rate and particle size has been analyzed. Additionally, comparisons to stand-alone code (i.e., SPARC90) responses have also been obtained, so that prediction-to-data deviations can be discussed and attributed to either model grounds and/or model implementation in integral accident codes. This work has demonstrated that ASTEC-CPA limitations to capture fundamental trends of aerosol pool scrubbing are substantial (although the SGTR scenarios should not be properly considered within the CPA scope) and they stem from both original models (i.e., SPARC90) and model implementation. This work has been carried out within the European SARNET project of the VI Framework Program of EURATOM. (author)

Modeling systems relevant to the biodiesel production using the CPA equation of state

DEFF Research Database (Denmark)

Tsivintzelis, Ioannis; Ali, Shahid; Kontogeorgis, Georgios

2016-01-01

In this study, CPA parameters for heavy esters, glycerides, organic acids, and glycerol are presented, together with trends of these parameters against the van der Waals volume. Such trends allow the prediction of parameters for compounds for which data are not available. Pure fluid parameters we...

Modelling phase equilibria for acid gas mixtures using the CPA equation of state. Part V: Multicomponent mixtures containing CO₂ and alcohols

DEFF Research Database (Denmark)

Tsivintzelis, Ioannis; Kontogeorgis, Georgios M.

2015-01-01

of CPA for ternary and multicomponent CO2 mixtures containing alcohols (methanol, ethanol or propanol) water and hydrocarbons. This work belongs to a series of studies aiming to arrive in a single "engineering approach" for applying CPA to acid gas mixtures, without introducing significant changes...... to the model. In this direction, CPA results were obtained using various approaches, i.e. different association schemes for pure CO2 (assuming that it is a non-associating compound, or that it is a self-associating fluid with two, three or four association sites) and different possibilities for modelling...... mixtures of CO2 with water and alcohols (only use of one interaction parameter kij or assuming cross-association interactions and obtaining the relevant parameters either via a combining rule or using an experimental value for the cross-association energy). It is concluded that CPA is a powerful model...

Candidate Performance on the Business Environment and Concepts Section of the CPA Exam

Science.gov (United States)

Lindsay, D. H.; Tan, K. B.; Campbell, Annhenrie

2009-01-01

This paper examines how differences in curricular design of undergraduate accounting programs influence pass rates on the Business Environment and Concepts Section of the CPA Exam. The association of the pass rate of a school's accounting graduates to the design of the schools accounting program and to other school characteristics was examined…

An Analysis of CPA Firm Recruiters' Perceptions of Online Masters of Accounting Degrees

Science.gov (United States)

Metrejean, Eddie; Noland, Thomas G.

2011-01-01

Online education continues to grow at a rapid pace. Assessment of the effectiveness of online programs is needed to differentiate legitimate programs from diploma mills. The authors examined the perceptions of CPA firm recruiters on whether an online Master of Accounting (MACC) matters in the hiring decision. Results show that recruiters do not…

Application of the cubic-plus-association (CPA) equation of state to complex mixtures with aromatic hydrocarbons

DEFF Research Database (Denmark)

Folas, Georgios; Kontogeorgis, Georgios; Michelsen, Michael Locht

2006-01-01

The cubic-plus-association (CPA) equation of state is applied to phase equilibria of mixtures containing alcohols, glycols, water, and aromatic or olefinic hydrocarbons. Previously, CPA has been successfully used for mixtures containing various associating compounds (alcohols, glycols, amines......, organic acids, and water) and aliphatic hydrocarbons. We show in this work that the model can be satisfactorily extended to complex vapor-liquid-liquid equilibria with aromatic or olefinic hydrocarbons. The solvation between aromatics/olefinics and polar compounds is accounted for. This is particularly...... important for mixtures containing water and glycols, but less so for mixtures with alcohols. For water/hydrocarbons, a single binary interaction parameter which accounts for the solvation is fitted to the experimental liquid-liquid equilibria (LLE) data. The interaction parameter of the physical term...

Educational Competencies That Mid-Sized CPA Firms Value in Their Professional Accounting Staff

Science.gov (United States)

Margheim, Loren; Hora, Judith A.; Pattison, Diane

2010-01-01

This study examined the educational competencies mid-sized accounting firm partners value in their professional staff when making promotion decisions to senior, manager, and partner. Mid-sized firms were defined in this study to include all of the non-Big 4 national firms, the large regional CPA firms, and several large local firms. Over 1,380…

Hybridization effect on generation capability of an embedded CPA

Directory of Open Access Journals (Sweden)

M. Klach

2016-03-01

Full Text Available The purpose of this paper is to compare performances of two configurations of an embedded Claw Pole Alternator (CPA where the excitation winding is transferred to the stator side. These configurations are: the Simple Excited Automotive Alternator (SE2A and the Hybrid Excited Automotive Alternator (HE2A. Performed study is based on test at no-load and under load operation regimes, using Magnetic Equivalent Circuit (MEC models validated experimentally. It has been found that the hybrid Excited claw pole alternator provides higher performances, due to the increase of leakage flux through the integration of permanent magnets between adjacent rotor claws.

Application of artificial neural networks for the determination of proteins with CPA-pI by rayleigh light scattering technique

Energy Technology Data Exchange (ETDEWEB)

Dong Lijun [Department of Chemistry, Lanzhou University, Lanzhou 730000 (China); Chen Xingguo [Department of Chemistry, Lanzhou University, Lanzhou 730000 (China)]. E-mail: chenxg@lzu.edu.cn; Hu Zhide [Department of Chemistry, Lanzhou University, Lanzhou 730000 (China)

2007-05-15

The determination of proteins with 2-(4-chloro-2-phosphonophenylazo)-7-(4-iodophenylazo) -1,8-dihydroxynaphthalene-3,6-disulfonic acid (CPA-pI) by Rayleigh light scattering (RLS) was studied in this paper. The weak RLS of CPA-pI and BSA can be enhanced greatly by the addition of Al{sup 3+} at the pH 5.6 and an enhanced RLS signal was produced at 365-385 nm. Based on the reaction of CPA-pI, Al{sup 3+} and proteins, a new quantitative determination method for proteins has been developed. The effect of three variables for the determination of proteins was optimized by means of artificial neural networks (ANNs) using extended delta-bar-delta (EDBD) algorithms with the optimal network structure of 3-5-1. This method is very sensitive (2.5-35.4 {mu}g/ml for bovine serum albumin (BSA)), rapid (<2 min), simple (one step) and tolerance of most interfering substances. Six samples of protein in human serum were determined and the maximum relative error is no more than 2% and the recovery is between 95% and 105%.

Modeling vapor-liquid interfaces with the gradient theory in combination with the CPA equation of state

DEFF Research Database (Denmark)

Queimada, Antonio; Miqueu, C; Marrucho, IM

2005-01-01

and the correct phase equilibrium of water + hydrocarbon systems already obtained from CPA. In this work, preliminary studies involving the vapor-liquid interfacial tensions of some selected associating and non-associating pure components (water, ethanol, n-butane, n-pentane, n-hexane, n-heptane) are presented...

La naturaleza de la disputa entre el Norte y el Sur y las implicaciones del Tratado General de Paz para el proceso de formación de Sudán del Sur

OpenAIRE

Silva de Freitas, Jeane; Loyolla Kuhlmann, Paulo Roberto

2015-01-01

Este artículo tiene como objetivo analizar el proceso de formación de la República del Sudán del Sur y la implementación del Tratado General de Paz (CPA) en el ámbito de los factores que influenciaron la evolución del conflicto sudanés. Por lo tanto, el objetivo es resaltar la relevancia y las consecuencias de la implementación del CPA para los dos Estados Sudaneses a partir de algunas interrogantes: ¿Por qué este tratado fue pactado? ¿Qué objetivos esperaban alcanzar y por qué se...

A Community-Engaged Approach to Developing a Mobile Cancer Prevention App: The mCPA Study Protocol.

Science.gov (United States)

Smith, Selina Ann; Whitehead, Mary Smith; Sheats, Joyce; Mastromonico, Jeff; Yoo, Wonsuk; Coughlin, Steven Scott

2016-03-02

Rapid growth of mobile technologies has resulted in a proliferation of lifestyle-oriented mobile phone apps. However, most do not have a theoretical framework and few have been developed using a community-based participatory research approach. A community academic team will develop a theory-based, culturally tailored, mobile-enabled, Web-based app-the Mobile Cancer Prevention App (mCPA)-to promote adherence to dietary and physical activity guidelines. The aim of this study is to develop mCPA content with input from breast cancer survivors. Members of SISTAAH (Survivors Involving Supporters to Take Action in Advancing Health) Talk (N=12), treated for Stages I-IIIc breast cancer for less than 1 year, 75 years of age or younger, and English-speaking and writing, will be recruited to participate in the study. To develop the app content, breast cancer survivors will engage with researchers in videotaped and audiotaped sessions, including (1) didactic instructions with goals for, benefits of, and strategies to enhance dietary intake and physical activity, (2) guided discussions for setting individualized goals, monitoring progress, and providing or receiving feedback, (3) experiential nutrition education through cooking demonstrations, and (4) interactive physical activity focused on walking, yoga, and strength training. Qualitative (focus group discussions and key informant interviews) and quantitative (sensory evaluation) methods will be used to evaluate the participatory process and outcomes. Investigators and participants anticipate development of an acceptable (frequency and duration of usage) feasible (structure, ease of use, features), and accessible mobile app available for intervention testing in early 2017. Depending on the availability of research funding, mCPA testing, which will be initiated in Miami, will be extended to Chicago, Houston, Philadelphia, and Los Angeles.

Phase equilibria modeling of methanol-containing systems with the CPA and sPC-SAFT equations of state

DEFF Research Database (Denmark)

Tybjerg, Peter Chr. V.; Kontogeorgis, Georgios; Michelsen, Michael Locht

2010-01-01

Proper representation at various conditions of phase equilibria of methanol-containing mixtures (with hydrocarbons, water, etc.) is Important for oil flow assurance purposes In this work two association equations of state. CPA and sPC-SAFT, are applied to methanol-containing mixtures The purpose ...

Online versus Face-to-Face Accounting Education: A Comparison of CPA Exam Outcomes across Matched Institutions

Science.gov (United States)

Morgan, John Daniel

2015-01-01

Programmatic-level comparisons are made between the certified public accountant (CPA) exam outcomes of two types of accounting programs: online or distance accounting programs and face-to-face or classroom accounting programs. After matching programs from each group on student selectivity at admission, the two types of programs are compared on CPA…

Metal organic framework Cu9Cl2(cpa)6 as tunable molecular magnet

Science.gov (United States)

Hamilton, Heather S. C.; Farmer, William M.; Skinner, Samuel F.; ter Haar, Leonard W.

2018-05-01

Chemical modifications of the magnetic metal organic framework (MOF) Cu9X2(cpa)6.42H2O (X = F, Cl, Br; cpa = anion of 2-carboxypentonicacid) have been investigated as a means of modifying, in a tunable manner, the magnetism of this 2-D material best described as a triangles-in-triangles (TIT) or triangulated-Kagomé-latttice (TKL). Since numerous theoretical studies have already attempted to describe the enigmatic ground state of this Heisenberg lattice, tunable chemical modifications should provide an excellent opportunity to expand this class of materials for studies concerning fundamental physics of frustrated spins, and applications such as adiabatic demagnetization refrigeration (ADR) that depend on the magnetocaloric effect (MCE). The chemical modification investigated is the intercalation of d- and f-orbital ions into the voids of the framework (channels of nearly 20 Å diameter). Magnetic measurements in the temperature range 1.8 - 300 K confirm signature features of TKL magnetism in intercalated samples persist, specifically: i) large negative Weiss constant (θCW); ii) absence of a phase transition down to 1.8 K; iii) minimum in χMT; iv) low temperature χMT values increasingly divergent at low fields indicating net ferromagnetic correlations; and, v) increasing field dependence of magnetization at low temperatures suggestive of intermediate plateaus, or ferrimagnetism, not saturation.

A Community-Engaged Approach to Developing a Mobile Cancer Prevention App: The mCPA Study Protocol

Science.gov (United States)

2016-01-01

Background Rapid growth of mobile technologies has resulted in a proliferation of lifestyle-oriented mobile phone apps. However, most do not have a theoretical framework and few have been developed using a community-based participatory research approach. A community academic team will develop a theory-based, culturally tailored, mobile-enabled, Web-based app—the Mobile Cancer Prevention App (mCPA)—to promote adherence to dietary and physical activity guidelines. Objective The aim of this study is to develop mCPA content with input from breast cancer survivors. Methods Members of SISTAAH (Survivors Involving Supporters to Take Action in Advancing Health) Talk (N=12), treated for Stages I-IIIc breast cancer for less than 1 year, 75 years of age or younger, and English-speaking and writing, will be recruited to participate in the study. To develop the app content, breast cancer survivors will engage with researchers in videotaped and audiotaped sessions, including (1) didactic instructions with goals for, benefits of, and strategies to enhance dietary intake and physical activity, (2) guided discussions for setting individualized goals, monitoring progress, and providing or receiving feedback, (3) experiential nutrition education through cooking demonstrations, and (4) interactive physical activity focused on walking, yoga, and strength training. Qualitative (focus group discussions and key informant interviews) and quantitative (sensory evaluation) methods will be used to evaluate the participatory process and outcomes. Results Investigators and participants anticipate development of an acceptable (frequency and duration of usage) feasible (structure, ease of use, features), and accessible mobile app available for intervention testing in early 2017. Conclusions Depending on the availability of research funding, mCPA testing, which will be initiated in Miami, will be extended to Chicago, Houston, Philadelphia, and Los Angeles. PMID:26935995

LA VIDEOCONFERENCIA DE ESCRITORIO COMO UNA HERRAMIENTA PARA EL DESARROLLO Y COLABORACIÓN A DISTANCIA

Directory of Open Access Journals (Sweden)

Ana Aurora Vidal Martínez

2014-01-01

Full Text Available Este ensayo propone una herramienta de interacción entre docentes y estudiantes de la Coordinación de Programas Académicos (CPA del Centro de Investigación en Alimentación y Desarrollo, A.C. (CIAD, A.C., situados en diferentes lugares geográficos de México, para compartir ideas, conocimiento, resolver problemas y planear estrategias de investigación. El proyecto se dividió en dos etapas. En la primera etapa se entrevistó a la coordinadora de la CPA, para conocer las necesidades específicas de interacción entre docentes y estudiantes, con el propósito de establecer las características mínimas que debería incluir la herramienta propuesta. Para el análisis de las diferentes alternativas se consideraron varios aspectos: la experiencia de los autores en el uso de equipos de videoconferencia de salón, consultas a proveedores, opiniones de colegas expertos en el área de videoconferencia de otras instituciones educativas y en bibliografía relacionada con el tema. Los involucrados coincidieron que la videoconferencia de escritorio es la herramienta que más se ajusta a los requerimientos expuestos, por considerarla: económica, ubicua y de uso simplificado para la transmisión-recepción de video, voz y datos. En la segunda etapa, después de utilizar la herramienta por un semestre, se realizaron entrevistas y encuestas a los usuarios, con el fin de evaluar el grado de satisfacción, comportamiento de docentes y estudiantes y la calidad de los materiales utilizados durante las sesiones de videoconferencia de escritorio. Los resultados obtenidos en la evaluación permiten concluir que la videoconferencia de escritorio fue la herramienta con la cual se logró alcanzar el objetivo planteado.

Ten years with the CPA (Cubic-Plus-Association) equation of state. Part 2. Cross-associating and multicomponent systems

DEFF Research Database (Denmark)

Kontogeorgis, Georgios; Michelsen, Michael Locht; Folas, Georgios

2006-01-01

In this second article of the review on the applications of the CPA (Cubic-Plus-Association) equation of state, the focus is placed on cross-associating systems. Various such mixtures are investigated, including (i) systems with two self-associating compounds ( e. g., water-alcohol systems...

The CPA Equation of State and an Activity Coefficient Model for Accurate Molar Enthalpy Calculations of Mixtures with Carbon Dioxide and Water/Brine

Energy Technology Data Exchange (ETDEWEB)

Myint, P. C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hao, Y. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Firoozabadi, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2015-03-27

Thermodynamic property calculations of mixtures containing carbon dioxide (CO₂) and water, including brines, are essential in theoretical models of many natural and industrial processes. The properties of greatest practical interest are density, solubility, and enthalpy. Many models for density and solubility calculations have been presented in the literature, but there exists only one study, by Spycher and Pruess, that has compared theoretical molar enthalpy predictions with experimental data [1]. In this report, we recommend two different models for enthalpy calculations: the CPA equation of state by Li and Firoozabadi [2], and the CO₂ activity coefficient model by Duan and Sun [3]. We show that the CPA equation of state, which has been demonstrated to provide good agreement with density and solubility data, also accurately calculates molar enthalpies of pure CO₂, pure water, and both CO₂-rich and aqueous (H₂O-rich) mixtures of the two species. It is applicable to a wider range of conditions than the Spycher and Pruess model. In aqueous sodium chloride (NaCl) mixtures, we show that Duan and Sun’s model yields accurate results for the partial molar enthalpy of CO₂. It can be combined with another model for the brine enthalpy to calculate the molar enthalpy of H₂O-CO₂-NaCl mixtures. We conclude by explaining how the CPA equation of state may be modified to further improve agreement with experiments. This generalized CPA is the basis of our future work on this topic.

The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study.

Science.gov (United States)

Touret, M; Sarda, N; Gharib, A; Geffard, M; Jouvet, M

1991-01-01

In the rat, the insomnia which follows the administration of parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, is transiently reversed either by intra-cisternal injection of L-5-HTP or by an associated injection of 5-HTP and an L-aromatic-acid-decarboxylase inhibitor (benserazide). Histochemical, immunohistochemical and chemical investigations showed that 5-HTP administration does not lead to a detectable increase in cerebral 5-HT. These findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP.

Expression, purification and preliminary X-ray characterization of dl-2-haloacid dehalogenase from Methylobacterium sp. CPA1

Energy Technology Data Exchange (ETDEWEB)

Omi, Rie [Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011 (Japan); Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585 (Japan); Jitsumori, Keiji; Yamauchi, Takahiro; Ichiyama, Susumu; Kurihara, Tatsuo; Esaki, Nobuyoshi [Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011 (Japan); Kamiya, Nobuo; Hirotsu, Ken, E-mail: hirotsu@sci.osaka-cu.ac.jp; Miyahara, Ikuko [Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585 (Japan); Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011 (Japan)

2007-07-01

A recombinant form of dl-2-haloacid dehalogenase from Methylobacterium sp. CPA1 has been expressed in E. coli, purified and crystallized. The crystal belongs to space group P6{sub 3}. Diffraction data have been collected to 1.75 Å resolution. dl-2-Haloacid dehalogenase from Methylobacterium sp. CPA1 (dl-DEX Mb) is a unique enzyme that catalyzes the dehalogenation reaction without the formation of an ester intermediate. A recombinant form of dl-DEX Mb has been expressed in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion method. The crystal belongs to the hexagonal space group P6{sub 3}, with unit-cell parameters a = b = 186.2, c = 114.4 Å. The crystals are likely to contain between four and eight monomers in the asymmetric unit, with a V{sub M} value of 4.20–2.10 Å{sup 3} Da{sup −1}. A self-rotation function revealed peaks on the χ = 180° section. X-ray data have been collected to 1.75 Å resolution.

78 FR 9731 - Gulf of Mexico, Outer Continental Shelf (OCS), Central Planning Area (CPA) Oil and Gas Lease Sale...

Science.gov (United States)

2013-02-11

... Environmental Impact Statement (Multisale FEIS). Authority: This NOA is published pursuant to the regulations... the NEPA process. The Multisale FEIS evaluated the environmental and socioeconomic impacts for CPA... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management Gulf of Mexico, Outer Continental...

Simultaneous Description of Activity Coefficients and Solubility with eCPA

DEFF Research Database (Denmark)

Schlaikjer, Anders; Thomsen, Kaj; Kontogeorgis, Georgios

2017-01-01

with salt specific parameters. The focus is on accurate description of the salt solubility, and low deviation correlations are obtained for all salts investigated. The inclusion of the solubility data in the parametrization has, compared to parameters only parametrized to osmotic coefficients and activity...... coefficients, not significantly affected the deviations of the osmotic coefficients and activity coefficients. The average deviations of the activity coefficient does increase slightly and it was found that the increase in deviations was almost entirely due to reduced accuracy at high temperature and high...... molality. The model is, furthermore, compared to the activity coefficient model, Extended UNIQUAC. It is shown that the eCPA provides more accurate solubility description at higher temperatures than Extended UNIQUAC but also that Extended UNIQUAC is slightly better at describing the activity coefficients...

La videoconferencia de escritorio como un instrumento para el desarrollo y colaboración a distancia

Directory of Open Access Journals (Sweden)

Ana Aurora Vidal Martínez

2014-05-01

Full Text Available Este ensayo propone una herramienta de interacción entre docentes y estudiantes de la Coordinación de Programas Académicos (CPA del Centro de Investigación en Alimentación y Desarrollo, A.C. (CIAD, A.C., situados en diferentes lugares geográficos de México, para compartir ideas, conocimiento, resolver problemas y planear estrategias de investigación. El proyecto se dividió en dos etapas. En la primera etapa se entrevistó a la coordinadora de la CPA, para conocer las necesidades específicas de interacción entre docentes y estudiantes, con el propósito de establecer las características mínimas que debería incluir la herramienta propuesta. Para el análisis de las diferentes alternativas se consideraron varios aspectos: la experiencia de los autores en el uso de equipos de videoconferencia de salón, consultas a proveedores, opiniones de colegas expertos en el área de videoconferencia de otras instituciones educativas y en bibliografía relacionada con el tema. Los involucrados coincidieron que la videoconferencia de escritorio es la herramienta que más se ajusta a los requerimientos expuestos, por considerarla: económica, ubicua y de uso simplificado para la transmisión-recepción de video, voz y datos. En la segunda etapa, después de utilizar la herramienta por un semestre, se realizaron entrevistas y encuestas a los usuarios, con el fin de evaluar el grado de satisfacción, comportamiento de docentes y estudiantes y la calidad de los materiales utilizados durante las sesiones de videoconferencia de escritorio. Los resultados obtenidos en la evaluación permiten concluir que la videoconferencia de escritorio fue la herramienta con la cual se logró alcanzar el objetivo planteado. This essay proposes an interaction tool between teachers and students of the Coordination of Academic Programs (CPA Center for Food Research and Development, AC (CIAD, AC, located in different geographical locations, to share ideas, knowledge, solve

Solid-Liquid Equilibria for Many-component Mixtures Using Cubic-Plus-Association (CPA) equation of state

DEFF Research Database (Denmark)

Fettouhi, André; Thomsen, Kaj

2010-01-01

In the creation of liquefied natural gas the formation of solids play a substantial role, hence detailed knowledge is needed about solid-liquid equilibria (SLE). In this abstract we shortly summarize the work we have carried out at CERE over the past year with SLE for many-component mixtures usin...... the Cubic-Plus-Association (CPA) equation of state. Components used in this work are highly relevant to the oil and gas industry and include light and heavy hydrocarbons, alcohols, water and carbon dioxide....

THE CPA QUALIFICATION METHOD BASED ON THE GAUSSIAN CURVE FITTING

Directory of Open Access Journals (Sweden)

M.T. Adithia

2015-01-01

Full Text Available The Correlation Power Analysis (CPA attack is an attack on cryptographic devices, especially smart cards. The results of the attack are correlation traces. Based on the correlation traces, an evaluation is done to observe whether significant peaks appear in the traces or not. The evaluation is done manually, by experts. If significant peaks appear then the smart card is not considered secure since it is assumed that the secret key is revealed. We develop a method that objectively detects peaks and decides which peak is significant. We conclude that using the Gaussian curve fitting method, the subjective qualification of the peak significance can be objectified. Thus, better decisions can be taken by security experts. We also conclude that the Gaussian curve fitting method is able to show the influence of peak sizes, especially the width and height, to a significance of a particular peak.

Equation of state modelling of systems with ionic liquids: Literature review and application with the Cubic Plus Association (CPA) model

DEFF Research Database (Denmark)

Maia, Filipa Meireles; Tsivintzelis, Ioannis; Rodriguez, Oscar

2012-01-01

For the last decade ionic liquids have been regarded as compounds of interest by the academic and industrial communities. These compounds present several advantages when compared to other typical solvents. However, because of their novelty, a deep understanding of their phase behaviour and their ......For the last decade ionic liquids have been regarded as compounds of interest by the academic and industrial communities. These compounds present several advantages when compared to other typical solvents. However, because of their novelty, a deep understanding of their phase behaviour...... and their interactions with other components is still needed. In this work, we made a review of literature studies on modelling systems with ionic liquids using equation of state models. Furthermore, we applied the Cubic Plus Association (CPA) equation of state to describe the phase behaviour of two ionic liquids, 1...... is in progress for improving the modelling of LLE with the CPA equation of state....

On the predictive capabilities of CPA for applications in the chemical industry: Mulficomponent mixtures containing methyl-methacrylate, dimethyl-ether or acetic acid

DEFF Research Database (Denmark)

Tsivintzelis, Ioannis; Kontogeorgis, Georgios

2014-01-01

mixtures exhibiting vapor-liquid (VLE) and/or liquid-liquid (LLE) equilibrium. The first two cases include mixtures of methyl-methacrylate with acetone or methanol and dimethyl-ether with ethanol, respectively. In these two cases, the classical form of CPA is used. The third case involves aqueous mixtures...... for the acetic acid-water system for which different parameter sets at different temperatures can be recommended. Even with the use of CPA-HV mixing rules, modeling of the acetic acid-water system with few interaction parameters remains a challenging task. Excellent simultaneous VLE and LLE correlation...... is obtained for complex systems such as aqueous mixtures with ethers and esters. The multicomponent results are, with a few exceptions, very satisfactory, especially for the vapor-liquid equilibrium cases. For the demanding aqueous acetic acid-water containing systems, one parameter set is recommended...

Modeling phase equilibria for acid gas mixtures using the CPA equation of state. Part II: Binary mixtures with CO2

DEFF Research Database (Denmark)

Tsivintzelis, Ioannis; Kontogeorgis, Georgios; Michelsen, Michael Locht

2011-01-01

In Part I of this series of articles, the study of H2S mixtures has been presented with CPA. In this study the phase behavior of CO2 containing mixtures is modeled. Binary mixtures with water, alcohols, glycols and hydrocarbons are investigated. Both phase equilibria (vapor–liquid and liquid–liqu...

Recent applications of the cubic-plus-association (CPA) equation of state to industrially important systems

DEFF Research Database (Denmark)

Folas, Georgios; Derawi, Samer; Michelsen, Michael Locht

2005-01-01

. Very satisfactory VLE and SLE prediction is achieved for alcohol-hydrocarbon systems, while the sensitivity of the LLE to the interaction parameter is demonstrated. It has been shown that CPA can perform VLE/LLE/SLE calculations in the case of alcohol-hydrocarbon binary systems with a single...... interaction parameter. Satisfactory SLE correlation of alcohol/glycol-water systems is achieved using a single interaction parameter over an extended temperature range. Moreover, satisfactory prediction was achieved for the multiphase equilibria of the mixture acetic acid-water-hexane based solely on binary...

[An experimental study on the Chinese lung adenocarcinoma cell clone CPA-Yang1-BR with brain metastasis potency in nude mice and in vivo imaging research].

Science.gov (United States)

Lei, Bei; Cao, Jie; Shen, Jie; Zhao, Lanxiang; Liang, Sheng; Meng, Qinggang; Xie, Wenhui; Yang, Shunfang

2013-08-20

Lung cancer is the leading cause of cancer-related death in men and women. It is also the most common cause of brain metastases. A brain metastasis model is difficult to be established because of the presence of the blood-brain barrier (BBB) and the lack of optimal methods for detecting brain metastasis in nude mice. Thus, the establishment of a Chinese lung adenocarcinoma cell line and its animal model with brain metastasis potency and in vivo research is of great significance. CPA-Yang1 cells were obtained from a patient with human lung adenocarcinoma by lentiviral vector-mediated transfection of green fluorescence protein. Intracardiac inoculation of the cells was performed in nude mice, and brain metastatic lesions were detected using micro ¹⁸F FDG-PET/CT scanners, small animal in vivo imaging system for fluorescence, radionuclide and X ray fused imaging, magnetic resonance imaging (MRI) with sense body detection, and resection. The samples were divided into two parts for cell culture and histological diagnosis. The process was repeated in vivo and in vitro for four cycles to obtain a novel cell clone, CPA-Yang1-BR. A novel cell clone, CPA-Yang1-BR, was obtained with a brain metastatic rate of 50%. The use of MRI for the detection of brain metastases has obvious advantages. An experimental Chinese lung adenocarcinoma cell clone (CPA-Yang1-BR) and its animal model with brain metastasis potency in nude mice were established. MRI with sense body or micro MRI may be used as a sensitive, accurate, and noninvasive method to detect experimental brain metastases in intact live immunodeficient mice. The results of this study may serve as a technical platform for brain metastases from lung adenocarcinoma.

Solid–liquid equilibria for binary and ternary systems with the Cubic-Plus-Association (CPA) equation of state

DEFF Research Database (Denmark)

Fettouhi, André; Thomsen, Kaj

2010-01-01

A systematic investigation of the CPA model's performance within solid-liquid equilibria (SLE) in binary mixtures (methane + ethane, methane + heptane, methane + benzene, methane + CO2, ethane + heptane, ethane + CO2, 1-propanol + 1,4-dioxane, ethanol + water, 2-propanol + water) is presented. Th....... The results from the binary mixtures are used to predict SLE behaviour in ternary mixtures (methane + ethane + heptane, methane + ethane + CO2). Our results are compared with experimental data found in the literature....

Application of the cubic-plus-association (CPA) equation of state to model the fluid phase behaviour of binary mixtures of water and tetrahydrofuran

DEFF Research Database (Denmark)

Herslund, Peter Jørgensen; Thomsen, Kaj; Abildskov, Jens

2013-01-01

The complex fluid phase behaviour, of the binary system comprised of water and tetrahydrofuran (THF) is modelled by use of the cubic-plus-association (CPA) equation of state. A total of seven modelling approaches are analysed, differing only in their way of describing THF and its interactions...

Modeling of Asphaltene Onset Precipitation Conditions with Cubic Plus Association (CPA) and Perturbed Chain Statistical Associating Fluid Theory (PC-SAFT) Equations of State

DEFF Research Database (Denmark)

Arya, Alay; Liang, Xiaodong; von Solms, Nicolas

2016-01-01

using various equations of state and empirical models. In the past few years, association models based on CPA and SAFT equations of state have been found to be promising models for studies of asphaltene precipitation. In this work, we compare asphaltene precipitation results obtained from different...

Modelling phase equilibria for acid gas mixtures using the CPA equation of state. Part VI. Multicomponent mixtures with glycols relevant to oil and gas and to liquid or supercritical CO2 transport applications

DEFF Research Database (Denmark)

Tsivintzelis, Ioannis; Kontogeorgis, Georgios M.

2016-01-01

to data on ternary and multicomponent mixtures) to model the phase behaviour of ternary and quaternary systems with CO2 and glycols. It is concluded that CPA performs satisfactorily for most multicomponent systems considered. Some differences between the various modelling approaches are observed....... This work is the last part of a series of studies, which aim to arrive in a single "engineering approach" for applying CPA to acid gas mixtures, without introducing significant changes to the model. An overall assessment, based also on the obtained results of this series (Tsivintzelis et al., 2010, 2011...

Evaluation of the PC-SAFT, SAFT and CPA equations of state in predicting derivative properties of selected non-polar and hydrogen-bonding compounds

DEFF Research Database (Denmark)

de Villiers, A.J.; Schwarz, C.E.; Burger, A.J.

2013-01-01

-temperature derivative. For 1-alcohols, both CPA and PC-SAFT accurately predict the isobaric heat capacity when modelled with the 3B association scheme, while SAFT is unable to capture the singularities present in the property irrespective of the association scheme used. None of the models are able to predict the speed...

CPA theory of the magnetization in rare earth transition metal alloys

International Nuclear Information System (INIS)

Szpunar, B.; Lindgaard, P.A.

1976-11-01

Calculations were made of the magnetic moment per atom of the transition metal and the rare earth metal in the intermetallic compounds, Gdsub(1-x)Nisub(x), Gdsub(1-x)Fesub(x), Gdsub(1-x)Cosub(x), and Ysub(1-x)Cosub(x). A simple model of the disordered alloy consisting of spins localized on the rare earth atoms and interacting with a narrow d-band is considered. The magnetic moment of the alloy at zero temperature is calculated within the molecular field and Hartree-Fock approximations. Disorder is treated in the coherent potential approximation. Results are in good agreement with the experimental data obtained for the crystalline and amorphous intermetallic compounds. It is shown that the temperature dependence of the magnetic moments and Curie and ferrimagnetic compensation temperatures can be accounted for by a simple model assuming a RKKY interaction between the rare-earth moments and the transition metal pseudo spin. The interaction is mediated by an effective alloy medium calculated using the CPA theory and elliptic densities of states. (Auth.)

The Effects of the 150-Credit-Hour Requirement for the Certified Public Accountant (CPA) Exam On the Career Intentions of Women and Minorities

Science.gov (United States)

Bierstaker, James Lloyd; Howe, Martha A.; Seol, Inshik

2005-01-01

In most states, students who sit for the certified public accountant (CPA) examination are now required to have 150 credit hours of college education. In this article, the authors examined the effects of this requirement on the career intentions of women and minorities. The authors collected data from 600 accounting students and the results…

Reação de clones de bananeira(Musa spp. ao nematóide Meloidogyne incognita (Kofoid & White, 1919 Chitwood, 1949, Raça 2

Directory of Open Access Journals (Sweden)

Vilas Boas Lenisa Cezar

2002-01-01

Full Text Available O trabalho teve por objetivo estudar em condições de casa de vegetação a reação de clones de bananeira, em relação a Meloidogyne incognita raça 2. Mudas micropropagadas foram inoculadas, utilizando-se da suspensão de M. incognita, formada de ovos e de juvenis do segundo estádio, totalizando 20.000 / muda. A inoculação foi feita após cinco dias do transplante das mudas para sacos de plástico preto de cinco litros de capacidade, contendo solo, areia e esterco, na proporção 3:1:1, esterilizado em caldeira a 100ºC, por duas horas. O delineamento experimental foi o inteiramente casualizado, com quatro repetições. Após 120 dias, os clones foram avaliados. Determinou-se o número de ovos e juvenis contido no sistema radicular, sendo utilizado o clone CPA-34, a cultivar Grande Naine, como padrão de suscetibilidade. Amostras de 200 cm³ de solo foram coletadas para a determinação do número de nematóides no solo. De acordo com os fatores de reprodução (Pf/Pi, verificou-se que o clone CPA-34 apresentou-se suscetível ao nematóide, como era esperado, com o maior fator de reprodução, seguido do clone CPA-49, da cultivar Maçã, com índice superior a um. Os demais clones testados apresentaram fator de reprodução menor que um, indicando certa resistência ao nematóide M. incognita raça 2. Entretanto, nas análises estatísticas, foram verificadas diferenças significativas entre o clone-padrão CPA-34, quando comparado com os clones CPA-58 e CPA-54. Para os resultados de peso de raízes e peso da parte aérea, a diferença foi significativa (1% para todos os clones testados, apresentando os maiores valores para os clones não inoculados.

Mutual Solubility of MEG, Water and Reservoir Fluid: Experimental Measurements and Modeling using the CPA Equation of State

DEFF Research Database (Denmark)

Riaz, Muhammad; Kontogeorgis, Georgios; Stenby, Erling Halfdan

2011-01-01

This work presents new experimental phase equilibrium data of binary MEG-reservoir fluid and ternary MEG-water-reservoir fluid systems at temperatures 275-326 K and at atmospheric pressure. The reservoir fluid consists of a natural gas condensate from a Statoil operated gas field in the North Sea...... compounds. It has also been extended to reservoir fluids in presence of water and polar chemicals using a Pedersen like characterization method with modified correlations for critical temperature, pressure and acentric factor. In this work CPA is applied to the prediction of mutual solubility of reservoir...

Modeling MEA with the CPA equation of state: A parameter estimation study adding local search to PSO algorithm

DEFF Research Database (Denmark)

Santos, Letícia Cotia dos; Tavares, Frederico Wanderley; Ahón, Victor Rolando Ruiz

2015-01-01

parameters for MEA. This work proposes adding LLE information systematically in the CPA parameter estimation procedure. At first, the parameter search space is defined by the results from the PSO sensitivity analysis for VLE considering the experimental error for vapor pressures and liquid densities...... (objective function cut off). Then, two possible methodologies are discussed: the first one uses all the possible parameter sets and check them against the LLE and VLE experimental data. The second method explicitly incorporates LLE information into the objective function and uses both PSO and PSO...

Electrolyte CPA equation of state for very high temperature and pressure reservoir and basin applications

Science.gov (United States)

Courtial, Xavier; Ferrando, Nicolas; de Hemptinne, Jean-Charles; Mougin, Pascal

2014-10-01

In this work, an electrolyte version of the Cubic Plus Association (eCPA) equation of state has been adapted to systems containing CH4, CO2, H2O and NaCl (up to 5 molal) at pressures up to 200 MPa and temperatures up to 773 K for salt-free systems and 573 K for salt-containing systems. Its purpose is to represent the phase behavior (including salting-out effect and critical point) and the phase densities in a range of temperature and pressure encountered in deep reservoirs and basins. The goal of the parameterization proposed is not to reach a very high accuracy for phase equilibrium and volumetric properties, but rather to develop a semi-predictive approach to model the phase and volumetric behavior of this system while allowing an easy extension to other compounds. Without salt, predictions for pure component vapor pressures and liquid molar volumes present an average absolute deviation (AAD) lower than 3% compared to experimental reference values. The pure component molar volumes out of saturation show an AAD lower than 4%. The highest deviations in densities are observed as expected in the vicinity of the critical coordinates of pure water and this effect increases when gases or salts are added to the system. For each binary system, CH4 + CO2, CH4 + H2O and CO2 + H2O, binary interaction parameters have been fitted to correctly represent the shape of the fluid phase envelopes (including all critical points) in the entire temperature and pressure range considered (219 K to 633 K and up to 250 MPa). The methane concentration in both phases of the CH4 + CO2 binary system is represented with an AAD lower than 9%. The methane solubility in water is represented within 16% and 8% for the methane content of the vapor. The CO2 solubility in water is within 26%, while the CO2 in the vapor phase shows an average deviation of 12%. All molar volumes are represented with an AAD lower than 3%. The few VLE experimental data for the CH4 + CO2 + H2O ternary system are fairly well

Contradicción, imparcialidad e inmediación en la ley de enjuiciamiento civil española: algunos problemas para la consolidación de estos principios en la práctica Contradiction, impartiality and inmediacy in Spanish civil procedure act: Some problems for the consolidation of this principles in practice

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Fernando Santelices Ariztía

2012-01-01

Full Text Available El presente trabajo constituye la investigación final realizada por el autor para el Máster en Ciencias Jurídicas en la Universidad Pompeu Fabra en Barcelona. El texto incorpora algunas correcciones para efectos de su publicación. En el mismo, se efectúa un análisis de la Ley de Enjuiciamiento Civil española (LEC a partir de la observación de audiencias, la realización de entrevistas y la revisión de doctrina y jurisprudencia con la finalidad de verificar en la práctica la materialización de los principios de Oralidad, Contradicción e Inmediación que consagra la ley. El trabajo presenta una breve descripción del estado actual del sistema de justicia civil en España y de las principales audiencias consagradas en la LEC para los procesos declarativos. Luego, el autor describe y desarrolla una serie de aspectos problemáticos que, a su juicio, se presentan en la práctica a partir de ciertas normas de la LEC y desde las técnicas de litigación oral. Consciente de la influencia que representa la LEC para el proceso de reforma a la justicia civil en Chile el autor efectúa un breve repaso del proyecto de Código Procesal Civil chileno del año 2009, constatando como éste supera algunos de los problemas observados en la LEC pero que a su vez mantiene otros, los que, a juicio del autor, pueden influir en la correcta implementación y desarrollo en la práctica de la reforma al proceso civil en Chile. Finalmente, se presentan algunas propuestas concretas para corregir y mejorar los problemas observados en la LEC. Como señala su autor, este trabajo tiene por finalidad constituir un aporte al debate sobre la reforma procesal civil, haciendo presente la importancia que tiene recoger las buenas y malas experiencias que en la práctica presentan otros sistemas procesales orales, incluyendo la reforma procesal penal chilena, dada la distancia que muchas veces se produce entre la teoría y la práctica.This text is the final study conducted

Experimental measurement of phase equilibrium for gas hydrates of refrigerants, and thermodynamic modeling by SRK, VPT and CPA EOSs

International Nuclear Information System (INIS)

Karamoddin, Maryam; Varaminian, Farshad

2013-01-01

Highlights: • Three-phase equilibrium data, (VL W H), were measured for HCFC22 and HFC134a hydrates. • The pressures were evaluated by simple EoSs (modified mixing rule) and CPA EOS. • The Kihara potential parameters were obtained by optimizing scheme for refrigerants. -- Abstract: In this study, three-phase equilibrium conditions of hydrate-liquid–vapor, (VL W H), were experimentally determined for chlorodifluoromethane and 1,1,1,2-tetrafluoroethane gas hydrates at temperatures ranging from (278 to 290) K and (280 to 285) K respectively, at pressures ranging from (0.2 to 0.8) MPa. Then the different models were presented for estimating of the hydrate dissociation conditions of chlorodifluoromethane, 1,1,1,2-tetrafluoroethane and 1,1-difluoroethane refrigerants. The cubic simple equations of state (SRK and VPT) and the cubic plus association equation of state (CPA) were employed for modeling the vapor and liquid phases, also van der Waals–Platteeuw statistical model was used for the solid hydrate phase. In this paper, the binary interaction parameters of classic and modified mixing rules were optimized by using two-phase equilibrium data (VL W H). The Kihara potential parameters in each refrigerant were estimated using obtained experimental equilibrium data (VL W H) and based on the optimization scheme by the Nelder Mead optimization method. The agreement between the experimental and the predicted pressure is acceptable by using these models. The average deviation of models for chlorodifluoromethane, 1,1,1,2-tetrafluoroethane, and 1,1-difluoroethane hydrates is about 3%, 4.3%, and 3.6%, respectively

High pressure measurement and CPA equation of state for solubility of carbon dioxide and hydrogen sulfide in 1-butyl-3-methylimidazolium acetate

International Nuclear Information System (INIS)

Haghtalab, Ali; Kheiri, Alireza

2015-01-01

Highlights: • Solubility of carbon dioxide in pure [bmim][acetate] is measured. • Simultaneous solubility of CO 2 + H 2 S in [bmim][acetate] is measured. • Both physical and chemical models are applied to modelling the (acid gas + IL) systems. • The CPA EoS is used for phase equilibrium calculation. • A reaction thermodynamic equilibrium model is used in liquid phase. - Abstract: Removal of acid gases such as CO 2 and H 2 S from natural gas is essential for commercial, safety and environmental protection that demonstrate the importance of gas sweetening process. Ionic liquids (IL) have been highly demanded as a green solvent to remove acid gases from sour natural gas and capturing of CO 2 from flue gases. In this work, the solubility of CO 2 in 1-butyl-3-methylimidazolium acetate ([bmim][Ac]) is measured at temperatures (303.15, 328.15, 343.15) K and pressure range of (0.1 to 3.9) MPa. Moreover, the experiments are carried out for simultaneous measurements of (CO 2 + H 2 S) (70% + 30% on a mole basis) solubility in the same ionic liquid at T = (303.15, 323.15, 343.15) K and a pressure range of (0.1 to 2.2) MPa. To model the solubility of acid gases in IL, both physical and chemical equilibria are applied so that the (vapour + liquid) equilibrium calculation is carried out through Cubic-Plus-Association (CPA) EoS. The reaction equilibrium thermodynamic model is used in liquid phase so that the chemical reaction is taking place between IL and acid gasses. The Henry’s and reaction equilibrium constants are obtained though optimization of the solubility data. Using CPA EOS, the pure parameters of [bmim][acetate] are optimised and consequently using these parameters, gas partial pressure calculation is performed for the (CO 2 + IL) and (CO 2 + H 2 S + IL) systems. For the (CO 2 + IL) system, the percent average absolute deviation (AAD%) of 4.83 is resulted and for the (H 2 S + CO 2 + IL) system the values of 18.8 and 13.7 are obtained for H 2 S and CO 2

Vapor-liquid, liquid-liquid and vapor-liquid-liquid equilibrium of binary and multicomponent systems with MEG modeling with the CPA EoS and an EoS/G(E) model

DEFF Research Database (Denmark)

Folas, Georgios; Kontogeorgis, Georgios; Michelsen, Michael Locht

2006-01-01

The cubic-plus-association (CPA) EoS is applied to multicomponent multiphase equilibria of systems containing MEG as a hydrate inhibitor. It is shown that the model provides very satisfactory prediction of the phase behavior for the systems tested. A more conventional engineering model for handling...

Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes.

Science.gov (United States)

Rotroff, Daniel M; Yee, Sook Wah; Zhou, Kaixin; Marvel, Skylar W; Shah, Hetal S; Jack, John R; Havener, Tammy M; Hedderson, Monique M; Kubo, Michiaki; Herman, Mark A; Gao, He; Mychaleckyi, Josyf C; McLeod, Howard L; Doria, Alessandro; Giacomini, Kathleen M; Pearson, Ewan R; Wagner, Michael J; Buse, John B; Motsinger-Reif, Alison A

2018-04-12

Metformin is the first line treatment for type 2 diabetes (T2D). Although widely prescribed, the glucose-lowering mechanism for metformin is incompletely understood. Here we used a genome-wide association approach in a diverse group of individuals with T2D from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) clinical trial to identify common and rare variants associated with HbA1c response to metformin treatment, and followed up these findings in four replication cohorts. Common variants in PRPF31 and CPA6 , were associated with worse and better metformin response, respectively (p<5×10 -6 ), and meta-analysis in independent cohorts displayed similar associations with metformin response (p=1.2×10 -8 and p=0.005, respectively). Previous studies have shown that PRPF31 (+/-) knockout mice have increased total body fat (p=1.78×10 -6 ) and increased fasted circulating glucose (p=5.73×10 -6 ). Furthermore, rare variants in STAT3 associated with worse metformin response( q <0.1). STAT3 is a ubiquitously expressed pleiotropic transcriptional activator that participates in the regulation of metabolism and feeding behavior. Here we provide novel evidence for associations of common and rare variants in PRPF31, CPA6, and STAT3 with metformin response that may provide insight into mechanisms important for metformin efficacy in T2D. © 2018 by the American Diabetes Association.

Establishment and Characterization of a Novel Chinese Human Lung Adenocarcinoma Cell Line CPA-Yang2 in Immunodeficient Mice

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Shunfang YANG

2009-10-01

Full Text Available Background and objective The recurrence, metastasis and multidrug resistance (MDR in lung cancer are the tough problems worldwide. This study was to establish a novel chinese lung adenocarcinoma cell line with high metastasis potential for exploring the mechanism of reccurrence, development and MDR in lung cancer. Methods The cell came from the abdominal dropsy of a fifty-six years old female patient with lung adenocarcinoma and the tumor markers CA125, CYFRA21-1, CEA, NSE were detected to be higher secretion by radioimmunoassay in the abdominal dropsy. Tumorigenicity of immunodeficient mice was confirmed in 8th passage. The cell growth curve was mapped. Analysis of chromosome karyotype was tested. The gene expression was measured by real-time quantitative PCR. Results The tumorigenesis rate started at 8th passage in 3/10 immunodeficient mice via subcutaneously and the fully tumorigenicity was at 11th passage as well as later passages. Under the microscope, the cell showed oval-shap and adherence. The chromosome karyotype analysis of the cells was sub-triploid. Approximately 1×106 and 1.5×106 cancerous cells were injected into left cardiac ventricle and tail vein of immunodeficient mice respectively. The results showed multiorgan metastasis in the mice after three-four weeks, including mandible, scapula, humerus, vertebral column, femur, rib and brain, liver, adrenal gland, pulmonary in the mice after inoculation. The bone metastasis rate was 100% in the tumor bearing mice by bone scintigraphy and pathology. Quantitative real-time PCR was used to examined and compared with SPC-A-1 lung adenocarcinoma, ESM1, VEGF-C, IL-6, IL-8, AR genes were overexpressed. The novel cell was named CPA-Yang2. Conclusion The characteristics of novel strain CPA-Yang2 is a highly metastasis cell line of Chinese lung adenocarcinoma. It has stable traits, highly metastasis ability and maybe is a MDR lung cancerous cell line. Of course, it’s a good experimental

Modeling phase equilibria for acid gas mixtures using the CPA equation of state. Part IV. Applications to mixtures of CO2 with alkanes

DEFF Research Database (Denmark)

Tsivintzelis, Ioannis; Ali, Shahid; Kontogeorgis, Georgios

2015-01-01

The thermodynamic properties of pure gaseous, liquid or supercritical CO2 and CO2 mixtures with hydrocarbons and other compounds such as water, alcohols, and glycols are very important in many processes in the oil and gas industry. Design of such processes requires use of accurate thermodynamic...... models, capable of predicting the complex phase behavior of multicomponent mixtures as well as their volumetric properties. In this direction, over the last several years, the cubic-plus-association (CPA) thermodynamic model has been successfully used for describing volumetric properties and phase...

KKR-CPA calculations of density of states and soft X-ray emission from disordered Li-Mg alloys

International Nuclear Information System (INIS)

Rajput, S.S.; Singru, R.M.; Prasad, R.

1994-01-01

The density of states (DOS) and soft X-ray spectra from disordered Li 1-x Mg x alloys have been calculated by using the charge self-consistent KKR-CPA method. We find that the DOS at the Fermi energy (E F ) shows an interesting behaviour as a function of x; it first increases in the range x=0.0 to 0.14, then shows a flat behaviour in the range x approx. 0.14 to 0.20 and finally decreases smoothly from x=0.20 to 0.60. We show that this behaviour of the DOS is related to the development of a neck in the Fermi surface and its smearing due to disorder scattering. Theoretical results for the soft X-ray emission spectra are compared with experimental results and are found to be in good accord. (author). 14 refs, 4 figs, 1 tab

Modelling phase equilibria for acid gas mixtures using the CPA equation of state. Part VI. Multicomponent mixtures with glycols relevant to oil and gas and to liquid or supercritical CO_2 transport applications

International Nuclear Information System (INIS)

Tsivintzelis, Ioannis; Kontogeorgis, Georgios M.

2016-01-01

Highlights: • CPA EoS was applied to predict the phase behaviour of multicomponent mixtures containing CO_2, glycols, water and alkanes. • Mixtures relevant to oil and gas, CO_2 capture and liquid or supercritical CO_2 transport applications were investigated. • Results are presented using various modelling approaches/association schemes. • The predicting ability of the model was evaluated against experimental data. • Conclusions for the best modelling approach are drawn. - Abstract: In this work the Cubic Plus Association (CPA) equation of state is applied to multicomponent mixtures containing CO_2 with alkanes, water, and glycols. Various modelling approaches are used i.e. different association schemes for pure CO_2 (assuming that it is a non-associating compound, or that it is a self-associating fluid with two, three or four association sites) and different possibilities for modelling mixtures of CO_2 with other hydrogen bonding fluids (only use of one interaction parameter k_i_j or assuming cross association interactions and obtaining the relevant parameters either via a combining rule or using an experimental value for the cross association energy). Initially, new binary interaction parameters were estimated for (CO_2 + glycol) binary mixtures. Having the binary parameters from the binary systems, the model was applied in a predictive way (i.e. no parameters were adjusted to data on ternary and multicomponent mixtures) to model the phase behaviour of ternary and quaternary systems with CO_2 and glycols. It is concluded that CPA performs satisfactorily for most multicomponent systems considered. Some differences between the various modelling approaches are observed. This work is the last part of a series of studies, which aim to arrive in a single “engineering approach” for applying CPA to acid gas mixtures, without introducing significant changes to the model. An overall assessment, based also on the obtained results of this series (Tsivintzelis

Simulation of experiment on aerosol behaviour at severe accident conditions in the LACE experimental facility with the ASTEC CPA code

International Nuclear Information System (INIS)

Kljenak, I.; Mavko, B.

2007-01-01

The experiment LACE LA4 on thermal-hydraulics and aerosol behavior in a nuclear power plant containment, which was performed in the LACE experimental facility, was simulated with the ASTEC CPA module of the severe accident computer code ASTEC V1.2. The specific purpose of the work was to assess the capability of the module (code) to simulate thermal-hydraulic conditions and aerosol behavior in the containment of a light-water-reactor nuclear power plant at severe accident conditions. The test was simulated with boundary conditions, described in the experiment report. Results of thermal-hydraulic conditions in the test vessel, as well as dry aerosol concentrations in the test vessel atmosphere, are compared to experimental results and analyzed. (author)

Development of all solid-state, high average power ultra-short pulse laser for X-ray generation. High average power CPA system and wavefront control of ultra short laser pulse

Energy Technology Data Exchange (ETDEWEB)

Harayama, Sayaka; Akaoka, Katsuaki; Tei, Kazuyoku; Kato, Masaaki; Niwa, Yoshito; Maruyama, Yoichiro; Matoba, Toru; Arisawa, Takashi; Takuma, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1998-03-01

We developed a prototype CPA laser system which is pumped by a all solid-state Nd:YAG laser. In a preliminary experiment, the output energy of 52mJ before compression was obtained when the pumping energy was 250mJ. To compensate the wavefront distortion, an adaptive optics has been developed. By using this wavefront control system, the laser beam with the distortion of 0.15{lambda} was obtained. (author)

Modeling Phase Equilibria for Acid Gas Mixtures Using the CPA Equation of State. I. Mixtures with H2S

DEFF Research Database (Denmark)

Tsivintzelis, Ioannis; Kontogeorgis, Georgios; Michelsen, Michael Locht

2010-01-01

(water, methanol, and glycols) are modeled assuming presence or not of cross-association interactions. Such interactions are accounted for using either a combining rule or a cross-solvation energy obtained from spectroscopic data. Using the parameters obtained from the binary systems, one ternary......The Cubic-Plus-Association (CPA) equation of state is applied to a large variety of mixtures containing H2S, which are of interest in the oil and gas industry. Binary H2S mixtures with alkanes, CO2, water, methanol, and glycols are first considered. The interactions of H2S with polar compounds...... and three quaternary mixtures are considered. It is shown that overall excellent correlation for binary, mixtures and satisfactory prediction results for multicomponent systems are obtained. There are significant differences between the various modeling approaches and the best results are obtained when...

Development of laser diode-pumped high average power solid-state laser for the pumping of Ti:sapphire CPA system

Energy Technology Data Exchange (ETDEWEB)

Maruyama, Yoichiro; Tei, Kazuyoku; Kato, Masaaki; Niwa, Yoshito; Harayama, Sayaka; Oba, Masaki; Matoba, Tohru; Arisawa, Takashi; Takuma, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1998-03-01

Laser diode pumped all solid state, high repetition frequency (PRF) and high energy Nd:YAG laser using zigzag slab crystals has been developed for the pumping source of Ti:sapphire CPA system. The pumping laser installs two main amplifiers which compose ring type amplifier configuration. The maximum amplification gain of the amplifier system is 140 and the condition of saturated amplification is achieved with this high gain. The average power of fundamental laser radiation is 250 W at the PRF of 200 Hz and the pulse duration is around 20 ns. The average power of second harmonic is 105 W at the PRF of 170 Hz and the pulse duration is about 16 ns. The beam profile of the second harmonic is near top hat and will be suitable for the pumping of Ti:sapphire laser crystal. The wall plug efficiency of the laser is 2.0 %. (author)

Liquid-liquid equilibria for binary and ternary systems containing glycols, aromatic hydrocarbons, and water: Experimental measurements and modeling with the CPA EoS

DEFF Research Database (Denmark)

Folas, Georgios; Kontogeorgis, Georgios; Michelsen, Michael Locht

2006-01-01

Liquid-liquid equilibrium data of four binary glycol + aromatic hydrocarbon systems and three ternary systems containing water have been measured at atmospheric pressure. The measured systems are monoethylene glycol (MEG) + benzene or toluene, triethylene glycol (TEG) + benzene or toluene, MEG...... + water + benzene, MEG + water + toluene, and TEG + water + toluene. The binary systems are correlated with the Cubic-Plus-Association (CPA) equation of state while the ternary systems are predicted from interaction parameters obtained from the binary systems. Very satisfactory liquid-liquid equilibrium...... correlations are obtained for the binary systems using temperature-independent interaction parameters, while adequate predictions are achieved for multicomponent water + glycol + aromatic hydrocarbons systems when accounting for the solvation between the aromatic hydrocarbons and glycols or water....

Tradução e adaptação para a língua portuguesa do In-hospital Utstein Style Traducción y adaptación al idioma portugués del instrumento In-hospital Utstein Style Translation and adaptation of the In-Hospital Utstein Style into the portuguese language

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Patrícia do Amaral Avansi

2008-09-01

Full Text Available A parada cardiorrespiratória (PCR é um evento potencialmente letal e a qualidade do atendimento prestado depende da agilidade, conhecimento e habilidade de toda a equipe envolvida. Desenvolvido em 1997, o In-hospital Utstein Style é um relatório padrão para coleta de dados significativos em PCR. O estudo objetivou realizar a tradução e adaptação à língua portuguesa do instrumento. O instrumento foi submetido ao processo de tradução e adaptação cultural. O resultado deste processo gerou um instrumento aplicado em fase de pré-teste a 20 pacientes vítimas de PCR. As variáveis de resultado não foram coletadas, pois pressupõe o acompanhamento destes pacientes ao longo do tempo. O ritmo de PCR mais comum foi atividade elétrica sem pulso (65%; o tempo médio para desfibrilar foi de 1,25 minutos. Houve itens sem resposta. Podemos concluir que o instrumento é aplicável à realidade brasileira, buscando melhor atendimento ao evento da PCR.El paro cardiopulmonar (PCP es un estado potencialmente letal, donde la calidad del servicio depende de la agilidad, conocimiento y habilidad del equipo involucrado. El In-hospital Utstein Style fue elaborado en 1997. Este instrumento que recolecta datos de importancia durante un PCP fue traducido y adaptado al portugués. De esta forma fue sometido al proceso de traducción y adaptación cultural. Se obtuvo como resultado un instrumento, el cual fue aplicado a 20 victimas de PCP a través de un pre-test. Las variables de resultado no fueron consideradas en la recolección de datos, pues suponía el seguimiento de los pacientes por un periodo prolongado. El ritmo del PCP más común fue la actividad eléctrica sin pulso (65% y el tiempo promedio de desfibrilación fue de 1,25 minutos. Algunos ítems no fueron respondidos. Se concluye que el instrumento puede ser aplicado al contexto brasileño, en busca de una mejor atención en casos de PCP.Cardiopulmonary arrest (CPA is a potentially lethal event

5-HT has contrasting effects in the frontal cortex, but not the hypothalamus, on changes in noradrenaline efflux induced by the monoamine releasing-agent, d-amphetamine, and the reuptake inhibitor, BTS 54 354.

Science.gov (United States)

Géranton, Sandrine M; Heal, David J; Stanford, S Clare

2004-03-01

There is extensive evidence for functional interactions between central noradrenergic and serotonergic neurones. Here, dual-probe microdialysis was used in freely-moving rats to compare the effects of 5-HT on noradrenergic transmission in the rat frontal cortex and hypothalamus. We studied the effects of the 5-HT synthesis inhibitor, para-chlorophenylalanine (pCPA; which depleted 5-HT stores in both the frontal cortex and the hypothalamus), on spontaneous efflux of noradrenaline and on the noradrenergic responses to d-amphetamine, and the monoamine reuptake inhibitor, BTS 54 354. pCPA pretreatment alone did not affect spontaneous noradrenaline efflux in either brain region, whether or not alpha2-autoreceptors were inactivated by administration of the alpha2-antagonist, atipamezole (1 mg/kg i.p). However, in the frontal cortex, pCPA pretreatment augmented the amplitude of, and prolonged, the noradrenergic response to local infusion of d-amphetamine (10 microM). In contrast, pCPA abolished the increase in cortical noradrenaline efflux induced by local infusion of BTS 54 354 (50 microM). In the hypothalamus, pCPA did not affect the amplitude of the response to either of these agents but did prolong the effects of d-amphetamine on noradrenaline efflux. These findings suggest that serotonergic transmission has complex effects on the noradrenergic response to drugs that increase noradrenergic transmission in the frontal cortex, but has less influence in the hypothalamus.

Independent control of arbitrary orders of dispersion at the high power end of CPA lasers

International Nuclear Information System (INIS)

Goerbe, M.; Jojart, P.; Szeged University, Szeged; Kovacs, M.; Osvay, K.

2010-01-01

Complete text of publication follows. One of the most crucial issues in chirped pulse amplification (CPA) systems is the precise temporal recompression of the pulses hitting the target. In case of few cycle high intensity lasers, the stabilization of the carrier-envelope phase (CEP) of the pulses is also required. An acousto-optical programmable dispersion filter can satisfy both aims, providing dispersion (pre)compensation up to the fourth order of dispersion and make the CEP shift stable. Its use is, however, limited to a pulse intensity of 100 MW/cm 2 , hence its application is restricted to the front end of the (OP)CPA laser systems. A simple optical arrangement consisting of wedges with different materials and different apex angles was proposed recently for isochronic control of CEP of a pulse train. In this paper we show that assembly of wedges can be specifically designed to tune only one of the dispersion coefficients, while all the others, including CEP, remain practically unchanged. Wedge pairs changing solely the zeroth (CEP) and second order (group delay) dispersion (GDD) are experimentally presented along with a triplet of wedges tuning the third order dispersion (TOD) only. The experiment was carried out with the use of spectrally resolved interferometry (SRI). A Michelson-interferometer was illuminated by 100 nm bandwidth laser pulses of a Ti:Sapphire oscillator. The sample arm of the interferometer contained the wedge assembly, set to near Brewster-angle incidence at each surfaces, designed for tuning the required order of dispersion. At the output of the interferometer the spectral interference between the pulses from the sample and reference arms was resolved with a spectrograph. The dispersion was tuned by perpendicular shift of the entire wedge assembly to the laser beam. In the measurements spectral interferograms were recorded and evaluated at each spatial position of the assembly. Three different wedge combinations, two doublets and a triplet

Liquid–liquid equilibria for reservoir fluids+monoethylene glycol and reservoir fluids+monoethylene glycol+water: Experimental measurements and modeling using the CPA EoS

DEFF Research Database (Denmark)

Frost, Michael; Kontogeorgis, Georgios; Stenby, Erling Halfdan

2013-01-01

for critical temperature, pressure and acentric factor.This work presents new phase equilibrium data for binary MEG/reservoir fluid and ternary MEG/water/reservoir fluid systems, where two reservoir fluids from Statoil operated fields are used. The solubility data are reported over a range of temperatures......The complex phase equilibrium between reservoir fluids and associating compounds like water and glycols has become more and more important as the increasing global energy demand pushes the oil industry to use advanced methods to increase oil recovery, such as increasing the use of various chemicals...... to ensure a constant and safe production. The CPA equation of state has been successfully applied in the past to well defined systems and gas condensates, containing associating compounds. It has also been extended to reservoir fluids in presence of water and polar chemicals using modified correlations...

Diseño de un sistema para el aprovechamiento integral de la cáscara de arroz; Design of a system for integral use of the rice husk

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Michel Errasti Cabrera

2015-04-01

Full Text Available El presente trabajo tiene como objetivo realizar el diseño de un horno que permitirá la combustión controlada de la cáscara de arroz para obtener una ceniza con propiedades puzolánicas; el cual es un producto demandado para la elaboración de materiales refractarios y como adición reactiva en los hormigones de altas prestaciones. El estudio estará centrado en la CPA productora de arroz “Eulalio García”, donde se pretende aprovechar la energía térmica de los gases de la combustión en distintos procesos agroindustriales. Los resultados muestran que la dimensión volumétrica de la cámara de combustión será de 0,72×0,72×1,06 m, mientras que la altura y el diámetro de la chimenea serán de 6,40 m y 0,42 m, respectivamente. El coeficiente de exceso de aire será de 1,55 y el volumen de aire a suministrar 4,34 m3/kgCA. La eficiencia del horno se estimó en 86,63 % y el calor útil en 10585,74 kJ/kgCA. The present paper aims to make the design of a furnace that allow controlled burning of rice husk for obtain a pozzolanic ash, which is a product demanded for the production of refractory materials and as an reactive addition in high performance concretes. The study will focus on CPA "Eulalio Garcia", which aims to exploit the thermal energy from the combustion gases in different agro-industrial processes. The results show that the volumetric dimension of the combustion chamber will be 0.72 × 0.72 × 1.06 m, while the height and diameter of the stack will be of 6.40 m and 0.42 m, respectively. The excess air ratio will be 1.55 and the volume of air to provide 4.34 m3/kgCA. Furnace efficiency was estimated to be 86.63 % and useful heat in 10585.74 kJ / KgCA.

Implementation of perturbed-chain statistical associating fluid theory (PC-SAFT), generalized (G)SAFT+cubic, and cubic-plus-association (CPA) for modeling thermophysical properties of selected 1-alkyl-3-methylimidazolium ionic liquids in a wide pressure range.

Science.gov (United States)

Polishuk, Ilya

2013-03-14

This study is the first comparative investigation of predicting the isochoric and the isobaric heat capacities, the isothermal and the isentropic compressibilities, the isobaric thermal expansibilities, the thermal pressure coefficients, and the sound velocities of ionic liquids by statistical associating fluid theory (SAFT) equation of state (EoS) models and cubic-plus-association (CPA). It is demonstrated that, taking into account the high uncertainty of the literature data (excluding sound velocities), the generalized for heavy compounds version of SAFT+Cubic (GSAFT+Cubic) appears as a robust estimator of the auxiliary thermodynamic properties under consideration. In the case of the ionic liquids the performance of PC-SAFT seems to be less accurate in comparison to ordinary compounds. In particular, PC-SAFT substantially overestimates heat capacities and underestimates the temperature and pressure dependencies of sound velocities and compressibilities. An undesired phenomenon of predicting high fictitious critical temperatures of ionic liquids by PC-SAFT should be noticed as well. CPA is the less accurate estimator of the liquid phase properties, but it is advantageous in modeling vapor pressures and vaporization enthalpies of ionic liquids. At the same time, the preliminary results indicate that the inaccuracies in predicting the deep vacuum vapor pressures of ionic liquids do not influence modeling of phase equilibria in their mixtures at much higher pressures.

El fracaso escolar y los enfoques de aprendizaje: medidas para la inclusión educativa

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Ana Belén Mirete Ruiz

2015-01-01

Full Text Available El índice de fracaso escolar existente actualmente en España resulta muy preocupante a pesar de las numerosas reformas educativas que se han llevado a cabo en los últimos años. Para analizar los factores motivacionales y de estrategias de aprendizaje que pueden estar incidiendo en la calidad del aprendizaje de los estudiantes se ha realizado una investigación con 281 estudiantes de Educación Secundaria Obligatoria a los que se ha aplicado el Cuestionario sobre Procesos de Aprendizaje (CPA. También se les ha planteado una serie de cuestiones sobre aspectos relacionados con la inclusión, los factores que pueden estar influyendo en el fracaso escolar y las medidas de mejora del rendimiento académico aplicadas por los estudiantes según sus enfoques de aprendizaje. Con ello se ha podido identificar las características de los aprendizajes de este grupo de estudiantes y se han planteado una serie de propuestas de mejora que de ser aplicadas podrían repercutir en la calidad de sus aprendizajes, en la mejora de su rendimiento académico y en minimizar los nefastos efectos del fracaso escolar en este nivel educativo.

Para-Hermitian and para-quaternionic manifolds

International Nuclear Information System (INIS)

Ivanov, S.; Zamkovoy, S.

2003-10-01

A set of canonical para-Hermitian connections on an almost para-Hermitian manifold is defined. A Para-hermitian version of the Apostolov-Gauduchon generalization of the Goldberg-Sachs theorem in General Relativity is given. It is proved that the Nijenhuis tensor of a Nearly para-Kaehler manifolds is parallel with respect to the canonical connection. Salamon's twistor construction on quaternionic manifold is adapted to the para-quaternionic case. A locally conformally hyper-para-Kaehler (hypersymplectic) flat structure with parallel Lee form on the Kodaira-Thurston complex surfaces modeled on S 1 x SL (2, R)-tilde is constructed. Anti-self-dual locally conformally hyper-para-Kaehler (hypersymplectic) neutral metrics with non vanishing Weyl tensor are obtained on the Inoe surfaces. An example of anti-self-dual neutral metric which is not locally conformally hyper-para-Kaehler (hypersymplectic) is constructed. (author)

Para-Hermitian and para-quaternionic manifolds

Energy Technology Data Exchange (ETDEWEB)

Ivanov, S [University of Sofia ' St. Kl. Ohridski' , Faculty of Mathematics and Informatics, Sofia (Bulgaria) and Abdus Salam International Centre for Theoretical Physics, Trieste (Italy); Zamkovoy, S [University of Sofia ' St. Kl. Ohridski' , Faculty of Mathematics and Informatics, Sofia (Bulgaria)

2003-10-01

A set of canonical para-Hermitian connections on an almost para-Hermitian manifold is defined. A Para-hermitian version of the Apostolov-Gauduchon generalization of the Goldberg-Sachs theorem in General Relativity is given. It is proved that the Nijenhuis tensor of a Nearly para-Kaehler manifolds is parallel with respect to the canonical connection. Salamon's twistor construction on quaternionic manifold is adapted to the para-quaternionic case. A locally conformally hyper-para-Kaehler (hypersymplectic) flat structure with parallel Lee form on the Kodaira-Thurston complex surfaces modeled on S{sup 1} x SL (2, R)-tilde is constructed. Anti-self-dual locally conformally hyper-para-Kaehler (hypersymplectic) neutral metrics with non vanishing Weyl tensor are obtained on the Inoe surfaces. An example of anti-self-dual neutral metric which is not locally conformally hyper-para-Kaehler (hypersymplectic) is constructed. (author)

Impacto de una intervención alimentaria con un concentrado proteico de Medicago sativa L (alfalfa, en niños pre escolares con desnutrición crónica

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María Soberón

2009-09-01

Full Text Available Introducción: Estudios realizados a nivel preclínico han demostrado el valor biológico del concentrado proteico obtenido de Medicago sativa L, alfalfa (CPA, por lo que este producto puede ser una alternativa para reducir la desnutrición. Objetivo: Evaluar el efecto del consumo de CPA por niños preescolares con desnutrición crónica, mediante indicadores bioquímicos y hematológicos. Diseño: Estudio analítico de intervención, de tipo longitudinal y prospectivo. Institución: Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Participantes: Niños preescolares con desnutrición crónica, provenientes de una comunidad de Pampas, Huancavelica, Perú. Intervenciones: Previo consentimiento informado de los padres, se evaluó el estado alimentario-nutricional, bioquímico y hematológico de 23 niños menores de seis años, para establecer la condición de desnutrición. Luego, se desarrolló una intervención alimentario nutricional con el CPA como complemento alimenticio, por 25 días, en niños seleccionados. Finalmente, se repitió la evaluación una vez concluido el período de intervención. Las determinaciones bioquímicas fueron hemoglobina, proteínas totales, albúmina y globulina, creatinina, transaminasas, y las hematológicas, hematocrito, recuento de reticulocitos. Se utilizó el programa Excel y t-student, a fin de obtener la inferencia en los resultados. Resultados: Para el indicador talla/edad, 84,5% de los niños padecía desnutrición crónica; respecto a calorías y nutrientes consumidos por los niños, los valores de energía estuvieron entre 563 kcal y 2 597 kcal; de proteína, 9,7 g a 78 g; de grasas, 5,1 g a 53,8 g; carbohidratos, 79,8 g a 495,1 g; calcio, entre 180,9 mg y 986 mg; y hierro, 1,9 mg y 21,5 mg. Los valores de hemoglobina, proteínas totales, globulinas, creatinina, transaminasas y hematocrito obtenidos antes y después de la ingesta de

三叉神经痛与面肌痉挛显微血管减压的显微解剖%Microdissection study of CPA for the functional neuprosurgery

Institute of Scientific and Technical Information of China (English)

黄建军; 马东; 伊志强; 白永文; 武日富; 马喜; 殷凤义; 鲍圣德

2009-01-01

目的 研究小脑脑桥角区的解剖结构,为三叉神经痛与面肌痉挛微血管减压手术提供解剖学依据.方法 16例成人头颅湿标本,采用乙状窦后入路,对小脑脑桥角区行显微解剖研究.结果 (1)上界为上项线中点下2 cm,下界为枕骨大孔上缘1 cm,内侧界距枕窦缘3 cm,外侧界为乳突基底内侧0.5 cm的骨窗中心恰与面听神经垂直对应,是微血管减压的最佳骨窗.(2)脑池段三叉神经与面听神经最宽距离平均为(11.19±0.12)mm.(3)岩静脉距离面听神经平均为(10.05±0.11)mm.结论 该区手术骨窗中心位置可行最佳选择.利用岩静脉与面听神经的间隙行微血管减压术无需切断岩静脉.%Objective To study the anatomy relationship among the vessles, nerves and bone landmarks in the region of CPA and provide operation-related anatomy knowledge for microvascular decompression of trigeminal neuralgia and hemifacial spasm. Method 16 cadaver specimens were used. 32 sides of CPA region were dissected with retrosigmoid approach. The optimal bone window center for Ⅶ,Ⅷ cranial nerves was localized and the relationship of nerves and vessels were observed and measured. Results (1)The bone window was 2 cm under the midpoint of superior nuchal line superiorly, 1 cm above superior margin of foramen magnum inferiorly, 3 cm lateral to occipital sinus medially, 0.5 cm medial to mamillary process base laterally. The center of the bone window was properly above the Ⅶ,Ⅷ cranial nerves. (2)The widest distance between the Ⅶ,Ⅷ cranial nerves and trigeminal nerve was 10.20～12.18 mm, mean (11.19±0. 12)mm in the cistern. (3)The distance between Ⅶ,Ⅷ cranial nerve and petrosal vein is 9.10±11.22 mm, mean(10.05±0.11)mm,and this interspace can be used to perform microvascular decompression without cutting off petrosal vein. Conclusions The bone window for microvascular decompression in CPA can be optimized to a special location. The locations of trigeminal

RELIGIÃO E NEGAÇÃO DA MODERNIDADE: A LEITURA FUNDAMENTALISTA DA BÍBLIA NAS REVISTAS DE ESCOLA BÍBLICA DOMINICAL DA ASSEMBLÉIA DE DEUS

OpenAIRE

Bertone de Oliveira Sousa

2010-01-01

Este artigo investiga as peculiaridades da leitura da Bíblia realizada pelos redatores das revistas de Escola Bíblica Dominical da Assembléia de Deus no Brasil, tendo como ponto de partida a ortodoxia doutrinária professada pela igreja e o fundamentalismo religioso presente em suas representações. Para isso, faz uma breve historicização da igreja, bem como uma problematização do conceito de fundamentalismo, para depois analisar-se as revistas de faixa etária de jovens e adultos da editora CPA...

Minimização da produção de lodo no tratamento de águas de abastecimento mediante uso do cloreto de polialumínio e sua disposição em estações de tratamento de esgotos Minimization of water treatment plant sludge production with polyaluminium chloride application and its disposal in wastewater treatment plants

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Sidney Seckler Ferreira Filho

2009-09-01

Full Text Available Uma das possibilidades para a redução da produção de lodo em estações de tratamento de água (ETAs é o uso do cloreto de polialumínio (CPA como coagulante, que pode ser aplicado de forma isolada ou em conjunto com sais de ferro. Este trabalho objetivou estudar o uso do CPA no que diz respeito à produção de lodo, bem como avaliar o impacto do lançamento de lodos de ETAs em estações de tratamento de esgoto (ETEs do tipo lodos ativados convencional. Observou-se que a produção de lodo do CPA apresentou valores próximos em comparação ao sulfato de alumínio, em torno de 4,75 mg de massa seca para cada 1 mg de Al, e o seu eventual lançamento para posterior processamento em ETEs deverá alterar a qualidade físico-química do lodo desidratado, sendo esta função do tipo e dosagem de coagulante e suas impurezas.One possible strategy to reduce sludge production in water treatment plant (WTP is the application of polyaluminium chloride (PAC as the sole coagulant or together with iron salts. The purpose of this paper was to investigate PAC usage with regard to sludge production as well as to evaluate impacts of discharging WTP sludge in activated sludge wastewater treatment plants (WWTPs. It was observed that PAC-based sludge production presented values close to aluminum sulfate-based sludge production, which was around 4.75 mg of dry solids per mg of Al. Furthermore, eventual discharge of PAC-based sludge in a WWTP should change the physical and chemical quality of the dry sludge, which is a function of coagulant type, coagulant dosage and of the impurities present in the coagulan's formulation.

Storage and methods for overcoming dormancy of the coral tree seedsArmazenamento e métodos para a superação da dormência de sementes de mulungu

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Ana Claudia da Silva

2013-03-01

� dificultado pela ocorrência de dormência tegumentar nas sementes. Assim, o objetivo do presente trabalho foi avaliar o efeito de diferentes métodos para superar a dormência em sementes de mulungu armazenadas em diferentes condições e períodos. O delineamento experimental foi inteiramente casualizado em esquema fatorial 5 x 2 (métodos para superar a dormência e tipos de armazenamento, em quatro repetições de 25 sementes. Os métodos foram (S1 testemunha; (S2 sementes escarificadas do lado oposto à micrópila; (S3 sementes escarificadas junto à micrópila; (S4 sementes imersas em água a 80 °C por cinco minutos e (S5 sementes imersas em água a 100 ºC por dois minutos. Os tipos de armazenamento foram por 25 meses em câmara fria e por um mês em ambiente do Laboratório. As características avaliadas foram porcentagem de emergência de plântulas (PE, tempo médio de emergência (TM, comprimento da parte aérea (CPA e da raiz (CR, diâmetro do colo (D, número de folhas (NF, biomassa seca das raízes (MSR e parte aérea das plântulas (MSPA. A porcentagem de emergência foi baixa nos tratamentos S1, S4 e S5 e as sementes armazenadas por apenas um mês foram mais afetadas quando imersas em água quente. Os maiores valores de CPA, CR, MSPA e NF foram observados nos tratamentos S2 e S3, nos quais ocorreu o menor tempo médio de emergência de plântulas. A dormência tegumentar das sementes de Erythrina velutina é superada com escarificação em lixa na extremidade oposta à micrópila ou junto à mesma. A dormência não é afetada pelos tipos de armazenamento e não é superada pela imersão em água quente.

Reliability of self-reported childhood physical abuse by adults and factors predictive of inconsistent reporting.

Science.gov (United States)

McKinney, Christy M; Harris, T Robert; Caetano, Raul

2009-01-01

Little is known about the reliability of self-reported child physical abuse (CPA) or CPA reporting practices. We estimated reliability and prevalence of self-reported CPA and identified factors predictive of inconsistent CPA reporting among 2,256 participants using surveys administered in 1995 and 2000. Reliability of CPA was fair to moderate (kappa = 0.41). Using a positive report from either survey, the prevalence of moderate (61.8%) and severe (12.0%) CPA was higher than at either survey alone. Compared to consistent reporters of having experienced CPA, inconsistent reporters were less likely to be > or = 30 years old (vs. 18-29) or Black (vs. White) and more likely to have report one type (vs. > or = 2) of CPA. These findings may assist researchers conducting and interpreting studies of CPA.

Determination of enterotoxigenic Clostridium perfringens by detecting of the cpa and cpe genes in stool samples of human origin, associated to gastrointestinal disease

International Nuclear Information System (INIS)

Oropeza Barrios, Gletty

2014-01-01

A molecular methodology is provided to the Centro Nacional de Referencia de Bacteriologia (CNRB) of the Instituto Costarricense de Investigacion y Ensenanza en Nutricion y Salud. An opportune diagnosis is realized of enterotoxigenic Clostridium perfringens in stool samples of sporadic cases and cases associated to foodborne disease outbreaks. DNA extraction of the white microorganism was performed through the methodology implemented in the CNRB. The technique of polymerase chain reaction (PCR) were adapted and standardized to establish the identification of C. perfringens to species level and detection of cpe gene coding for enterotoxin. The sensitivity of the method was determined in a selective culture medium for C. perfringens (Tryptose sulfite cycloserine Agar). A detection limit of about 2,3 x 10 4 CFU/ml was reached for the cpe gene and at least 2,8 x 10 2 CFU/ml for the cpa gene. Retrospective analysis of 61 samples of diarrheal stool suspicious by C. perfringens is performed to evaluate the efficacy of the technique. Three outbreaks caused by C. perfringens were identified and a 10% of positivity in the samples were obtained analyzed during the period between July 2012-March 2014 [es

Child physical abuse and the related PTSD in Taiwan: The role of Chinese cultural background and victims' subjective reactions.

Science.gov (United States)

Chou, Chia-Ying; Su, Yi-Jen; Wu, Ho-Mao; Chen, Sue-Huei

2011-01-01

This study aimed to investigate child physical abuse (CPA) while taking into account the more rigorous definitions of CPA in the Chinese societies. The prevalence of CPA and CPA-related PTSD were estimated, together with the examination of peri-traumatic subjective reactions and their impacts on PTSD. In a Taiwanese sample of 1966 4th to 8th graders, the Chinese version of UCLA PTSD Reaction Index for DSM-IV (Steinberg, Brymer, Decker, & Pynoos, 2004) was used to investigate the lifetime exposure to CPA. A sub-sample of 236 traumatized CPA victims was examined with respect to related PTSD symptoms. Thirty-four percent of the children had been exposed to CPA. The estimated current prevalence of full and partial PTSD was 13.6% and 16.9%, respectively. The current CPA prevalence was found to be higher than the Western countries, but lower than the previous findings in other East Asian societies. The full PTSD prevalence was close to the findings in the Western countries, whereas sub-clinical PTSD was less observed in Taiwan. Peri-traumatic subjective reactions, that is, Criterion A2 and perceived threat, were shown to be major predictors of PTSD symptom severity. The role of attitudes of child discipline in the Chinese societies in the prevalence of CPA and CPA-related PTSD is discussed. By providing explicit epidemiological information of CPA and CPA-related PTSD in Taiwan, the current study extends our understanding of CPA and CPA-related PTSD more broadly from Western countries to the Eastern societies. By separately investigating CPA relating to different perpetrators, cross-study comparison is enhanced. In the current study, the significance of considering cultural background in defining CPA and examining CPA-related PTSD was pointed out. Meanwhile, the role of victims' subjective reactions in the psychopathology of PTSD is highlighted. The findings and discussions could contribute for generating a more sophisticated clinical practice, especially with Asian or

Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases

International Nuclear Information System (INIS)

Reynolds, D.S.; Gurley, D.S.; Stevens, R.L.; Austen, K.F.; Serafin, W.E.; Sugarbaker, D.J.

1989-01-01

Human skin and lung mast cells and rodent peritoneal cells contain a carboxypeptidase in their secretory granules. The authors have screened human lung cDNA libraries with a mouse mast cell carboxypeptidase A (MC-CPA) cDNA probe to isolate a near-full-length cDNA that encodes human MC-CPA. The 5' end of the human MC-CPA transcript was defined by direct mRNA sequencing and by isolation and partial sequencing of the human MC-CPA gene. Human MC-CPA is predicted to be translated as a 417 amino acid preproenzyme which includes a 15 amino acid signal peptide and a 94-amino acid activation peptide. The mature human MC-CPA enzyme has a predicted size of 36.1 kDa, a net positive charge of 16 at neutral pH, and 86% amino acid sequence identity with mouse MC-CPA. DNA blot analyses showed that human MC-CPA mRNA is transcribed from a single locus in the human genome. Comparison of the human MC-CPA with mouse MC-CPA and with three rat pancreatic carboxypeptidases shows that these enzymes are encoded by distinct but homologous genes

New guidelines for cardiopulmonary resuscitation Nuevas directrices para la resucitación cardiopulmonar Novas diretrizes da ressuscitação cardiopulmonar

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Maria Celia Barcellos Dalri

2008-12-01

Full Text Available Cardiopulmonary arrest (CPA poses a severe threat to life; cardiopulmonary resuscitation (CPR represents a challenge for research and assessment by nurses and their team. This study presents the most recent international recommendations for care in case of cardiopulmonary heart arrest, based on the 2005 Guidelines by the American Heart Association (AHA. These CPR guidelines are based on a large-scale review process, organized by the International Liaison Committee on Resuscitation (ILCOR. High-quality basic and advanced CPR maneuvers can save lives.La parada cardiorrespiratoria (PCR es una ocurrencia que presenta una grave amenaza a la vida; la resucitación cardiopulmonar (RCP representa un desafío para la investigación y la evaluación por parte del enfermero y su equipo. Este estudio presenta las más recientes recomendaciones internacionales sobre la atención a la parada cardiorrespiratoria, basada en las Directrices de 2005 de la American Heart Asociation (AHA. Esas directrices sobre RCP se fundamentan en un proceso de revisión extenso, organizado por el International Liasion Committee on Resuscitation (ILCOR. Las maniobras básicas y avanzadas de RCP ofrecidas con calidad pueden salvar vidas.A parada cardiorrespiratória (PCR é intercorrência de grave ameaça à vida; a ressuscitação cardiopulmonar (RCP representa desafio para a investigação e a avaliação por parte do enfermeiro e sua equipe. Esse estudo apresenta as mais recentes recomendações internacionais sobre atendimento da parada cardiorrespiratória, baseado nas Diretrizes de 2005 da American Heart Association (AHA. Essas diretrizes sobre RCP fundamentam-se num processo de revisão extenso, organizado pelo International Liasion Committee on Resuscitation (ILCOR. As manobras básicas e avançadas de RCP com qualidade podem salvar vidas.

Rice genotypes evaluate under the interactive phytotoxic effect of acetic, propionic and butyric acidsAvaliação de genótipos de arroz sob o efeito fitotóxico interativo dos ácidos acético, propiônico e butírico

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Antonio Costa de Oliveira

2012-05-01

pelo ácido e as regressões estabelecidas para as variáveis CR e CPA revelaram 2 genótipos com estabilidade de crescimento radicular e 3 com estabilidade de crescimento de parte aérea frente ao estresse por ácidos orgânicos. Genótipos de maior rusticidade e desenvolvidas para sistema de irrigação por inundação se mostraram mais tolerântes ao ácido.

Monitoramento in situ e em tempo real de variáveis morfológicas do poli(cloreto de vinila usando espectroscopia NIR Monitoring in situ and in real time the morphological variables of pvc using NIR spectroscopy

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João M. de Faria Jr.

2009-06-01

Full Text Available Este trabalho ilustra o uso de espectroscopia do infravermelho próximo (NIRS para fins de monitoramento da polimerização em suspensão de cloreto de vinila em tempo real. Resultados inéditos mostraram que é possível acompanhar a evolução de importantes propriedades morfológicas de resinas de PVC [poli(cloreto de vinila], como por exemplo, BD (densidade aparente, CPA (absorção de plastificante a frio, DTP (distribuição de tamanho de partículas e Dp (diâmetro de partícula. Mostrou-se também, pela primeira vez, que é possível analisar quantitativamente, com o auxílio da sonda NIRS in situ, a estrutura morfológica da partícula de PVC. Com a possibilidade de predizer a evolução dinâmica dos parâmetros morfológicos em tempo real, mostrou-se que é possível injetar dispersantes e variar a velocidade de agitação durante a reação para fins de controle das variáveis BD, CPA e DTP do PVC, até que o ponto de identificação da partícula seja atingido. Por meio do monitoramento e da estratégia de controle proposta, é possível antecipar fugas de temperatura no reator, aumentar a segurança do processo, diminuir o tempo de desenvolvimento de resinas com características morfológicas diferenciadas, evitando perdas de margem oriundas da venda de produtos fora de especificação, e otimizar os recursos para o desenvolvimento de novos produtos.This work illustrates the use of near infrared spectroscopy (NIRS for monitoring of the suspension polymerization of vinyl chloride in real time. Obtained results showed that it is possible to track in situ and in real time important morphological properties of PVC resins, such as BD (bulk density, CPA (cold plasticizer absorption, PSD (particle size distribution and Dp (average particle diameter. It was also shown for the first time that it is possible to analyze quantitatively, with the help of in situ NIRS probe, the morphological structure of the PVC particles. As a consequence, it

Child Physical Abuse and the Related PTSD in Taiwan: The Role of Chinese Cultural Background and Victims' Subjective Reactions

Science.gov (United States)

Chou, Chia-Ying; Su, Yi-Jen; Wu, Ho-Mao; Chen, Sue-Huei

2011-01-01

Objective: This study aimed to investigate child physical abuse (CPA) while taking into account the more rigorous definitions of CPA in the Chinese societies. The prevalence of CPA and CPA-related PTSD were estimated, together with the examination of peri-traumatic subjective reactions and their impacts on PTSD. Methods: In a Taiwanese sample of…

Serie: Madera para construcción Acabados para madera

OpenAIRE

Sáenz-Muñoz, Marta; Instituto Tecnológico de Costa Rica

2012-01-01

Durante mucho tiempo, la madera ha sido utilizada como material de construcción para resolver principalmente objetivos estructurales; sin embargo, actualmente, el uso de la madera ha tomado mucho auge en la estética de las construcciones, para brindar apariencia y calidez. En la actualidad, el mercado ofrece una amplia gama productos para dar diversos “acabados” a la madera, los cuales sirven para resaltar la belleza de algunas de ellas, realzar características como el color y la veta, o bien...

L-2-Chloropropionic acid metabolism and disposition in male rats: relevance to cerebellar injury

International Nuclear Information System (INIS)

Wyatt, I.; Farnworth, M.; Gyte, A.J.; Lock, E.A.

1997-01-01

L-CPA produces selective necrosis to the granule cell layer of the rat cerebellum. As part of a study to understand the mechanism of selective toxicity we have investigated the metabolism and disposition of [2- 14 C]L-CPA in the rat, with particular emphasis on the brain. Following a single oral non-toxic dose of 250 mg/kg or a neurotoxic dose of 750 mg/kg or 250 mg/kg per day for 3 days, L-CPA is very rapidly absorbed from the gastrointestinal tract into the blood stream. Peak plasma concentrations of 2 mM and 6 mM L-CPA occurred within 1 h of dosing, and the compound was readily cleared from the plasma with a half-life of 2.6 h. The only metabolite detected in the plasma was 2-S-cysteinylpropanoic acid. About 60% of the dose is excreted in the urine in the first 24 h as unchanged L-CPA, with a smaller amount excreted as the mercapturate, 2-S-N-acetylcysteinylpropanoic acid. Little radiolabel from L-CPA is excreted in the faeces; however, ∝18% of a 250 mg/kg dose of L-CPA is eliminated as carbon dioxide. The radiolabel from [2- 14 C]L-CPA present in the cerebellum, forebrain and liver at all time intervals examined was L-CPA. There was some indication of retention of L-CPA in the brain relative to the plasma with a small but consistently higher concentration found in the cerebellum. Whole body autoradiography studies indicated some selective retention of radiolabel in the cerebellum after the third dose of 250 mg/kg [2- 14 C]L-CPA. Our findings indicate that the initial insult to the cerebellum following L-CPA administration is probably due to the parent compound however, the prolonged presence of 2-S-cysteinylpropanoic acid in the plasma and concomitant depletion of glutathione in the cerebellum may also play a role in the toxicity. The relevance of the slightly greater retention of L-CPA in the cerebellum to the selective neurotoxicity of L-CPA requires further study. (orig./MG). With 4 figs., 3 tabs

Childhood physical abuse, non-suicidal self-harm and attempted suicide amongst regular injecting drug users.

Science.gov (United States)

Darke, Shane; Torok, Michelle

2013-12-01

Childhood physical abuse (CPA), non-suicidal self-harm and attempted suicide are all highly prevalent amongst injecting drug users (IDU). This paper reported on the association of CPA with self-harm and attempted suicide. Cross-sectional study, with 300 IDU administered a structured interview examining the prevalence of CPA, non-suicidal self-harm and suicide attempts. CPA was reported by 74.3%, and severe CPA by 40.3%. A history of non-suicidal self-harm was reported by 23.7%, and 25.7% had attempted suicide. Non-suicidal self-harm preceded the suicide attempt in 83.3% of cases where both had occurred. Independent correlates of non-suicidal self-harm were: female gender (OR 3.62), avoided home due to conflict (OR 2.28) and more extensive polydrug use (OR 1.32). Independent correlates of attempted suicide were: severe CPA (OR 3.18), frequent CPA (OR 2.54), avoided home due to conflict (OR 3.95), female gender (OR 2.99), a positive screen for Conduct Disorder (OR 3.53), and more extensive polydrug use (OR 1.52). Those presenting to treatment agencies are highly likely to have a history of CPA, that may still influence their behaviours. Screening for histories of CPA and non-suicidal self-harm appears warranted when determining suicide risk for this population. At the population level, reductions in the rate of CPA, could possibly reduce the rate of subsequent suicidality. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

(±)-2-Chloropropionic acid elevates reactive oxygen species formation in human neutrophil granulocytes

International Nuclear Information System (INIS)

Aam, B.B.; Fonnum, F.

2006-01-01

(±)-2-Chloropropionic acid (2-CPA) is a neurotoxic compound which kills cerebellar granule cells in vivo, and makes cerebellar granule cells in vitro produce reactive oxygen species (ROS). We have studied the effect of 2-CPA on ROS formation in human neutrophil granulocytes in vitro. We found an increased formation of ROS after 2-CPA exposure using three different methods; the fluorescent probe DCFH-DA and the chemiluminescent probes lucigenin and luminol. Four different inhibitors of ROS formation were tested on the cells in combination with 2-CPA to characterize the signalling pathways. The spin-trap s-PBN, the ERK1/2 inhibitor U0126 and the antioxidant Vitamin E inhibited the 2-CPA-induced ROS formation completely, while the mitochondrial transition permeability pore blocker cyclosporine A inhibited the ROS formation partly. We also found that 2-CPA induced an increased nitric oxide production in the cells by using the Griess reagent. The level of reduced glutathione, measured with the DTNB assay, was decreased after exposure to high concentrations of 2-CPA. Western blotting analysis showed that 2-CPA exposure led to an elevated phosphorylation of ERK MAP kinase. This phosphorylation was inhibited by U0126. Based on these experiments it seems like the mechanisms for 2-CPA induced toxicity involves ROS formation and is similar in neutrophil granulocytes as earlier shown in cerebellar granule cells. This also implies that 2-CPA may be immunotoxic

Dry formulations of the biocontrol agent Candida sake CPA-1 using fluidised bed drying to control the main postharvest diseases on fruits.

Science.gov (United States)

Carbó, Anna; Torres, Rosario; Usall, Josep; Fons, Estanislau; Teixidó, Neus

2017-08-01

The biocontrol agent Candida sake CPA-1 is effective against several diseases. Consequently, the optimisation of a dry formulation of C. sake to improve its shelf life and manipulability is essential for increasing its potential with respect to future commercial applications. The present study aimed to optimise the conditions for making a dry formulation of C. sake using a fluidised bed drying system and then to determine the shelf life of the optimised formulation and its efficacy against Penicillium expansum on apples. The optimal conditions for the drying process were found to be 40 °C for 45 min and the use of potato starch as the carrier significantly enhanced the viability. However, none of the protective compounds tested increased the viability of the dried cells. A temperature of 25 °C for 10 min in phosphate buffer was considered as the optimum condition to recover the dried formulations. The dried formulations should be stored at 4 °C and air-packaged; moreover, shelf life assays indicated good results after 12 months of storage. The formulated products maintained their biocontrol efficacy. A fluidised bed drying system is a suitable process for dehydrating C. sake cells; moreover, the C. sake formulation is easy to pack, store and transport, and is a cost-effective process. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Serotonin depletion induces pessimistic-like behavior in a cognitive bias paradigm in pigs.

Science.gov (United States)

Stracke, Jenny; Otten, Winfried; Tuchscherer, Armin; Puppe, Birger; Düpjan, Sandra

2017-05-15

Cognitive and affective processes are highly interrelated. This has implications for neuropsychiatric disorders such as major depressive disorder in humans but also for the welfare of non-human animals. The brain serotonergic system might play a key role in mediating the relationship between cognitive functions and affective regulation. The aim of our study was to examine the influence of serotonin depletion on the affective state and cognitive processing in pigs, an important farm animal species but also a potential model species for biomedical research in humans. For this purpose, we modified a serotonin depletion model using para-chlorophenylalanine (pCPA) to decrease serotonin levels in brain areas involved in cognitive and affective processing (part 1). The consequences of serotonin depletion were then measured in two behavioral tests (part 2): the spatial judgement task (SJT), providing information about the effects of the affective state on cognitive processing, and the open field/novel object (OFNO) test, which measures behavioral reactions to novelty that are assumed to reflect affective state. In part 1, 40 pigs were treated with either pCPA or saline for six consecutive days. Serotonin levels were assessed in seven different brain regions 4, 5, 6, 11 and 13days after the first injection. Serotonin was significantly depleted in all analyzed brain regions up to 13days after the first application. In part 2, the pCPA model was applied to 48 animals in behavioral testing. Behavioral tests, the OFNO test and the SJT, were conducted both before and after pCPA/saline injections. While results from the OFNO tests were inconclusive, an effect of treatment as well as an effect of the phase (before and after treatment) was observed in the SJT. Animals treated with pCPA showed more pessimistic-like behavior, suggesting a more negative affective state due to serotonin depletion. Thus, our results confirm that the serotonergic system is a key player in cognitive

Bilateral cerebellopontine arachnoid cyst: A rare entity.

Science.gov (United States)

Sharma, Anand; Sharma, Achal; Mittal, Radhey S; Gandhi, Ashok

2015-01-01

Bilateral cerebellopontine angle (CPA) arachnoid cysts (ACs) are very rare: only one case is reported in literature. Pathogenesis of those cysts is unknown; they are thought to be congenital. The presenting symptoms of CPA AC are frequently nonspecific or otological. The management of ACs of the CPA is controversial. We are reporting two cases of bilateral CPA AC with their pathophysiology and review of literature.

Para-bosons and Para-fermions in Quantum Mechanics

International Nuclear Information System (INIS)

Cattani, M.S.D.; Fernandes, N.C.

1982-01-01

Within the framework of the ordinary quantum mechanics, a detailed study of the energy eigenfunctions of N identical particles using the irreducible representations of the permutation group in the Hilbert space is performed. It is shown that the para-states, as occurs with the boson and fermion states, are compatible with the postulates of quantum mechanics and with the principle of indistinguishability. A mathematical support for the existence of para-bosons and para-fermions is given. Gentile's quantum statistics is, in a certain sense, justified. (Author) [pt

Characterization of the pharmacokinetics, brain distribution, and therapeutic efficacy of the adenosine A1 receptor partial agonist 2'-deoxy-N6-cyclopentyladenosine in sarin-poisoned rats

International Nuclear Information System (INIS)

Bueters, Tjerk J.H.; IJzerman, Ad P.; Helden, Herman P.M. van; Danhof, Meindert

2003-01-01

Characterization of the pharmacokinetics, brain distribution, and therapeutic efficacy of the adenosine A 1 receptor partial agonist 2'-deoxy-N 6 -cyclopentyladenosine in sarin-poisoned rats. Bueters, T.J.H., IJzerman, A.P., Van Helden, H.P.M., and Danhof, M. (2003). The objective of the present study was to determine (1) the influence of sarin poisoning (144 μg/kg sc) on the pharmacokinetics and brain distribution of the adenosine A 1 receptor partial agonist 2'-deoxy-N 6 -cyclopentyladenosine (2'dCPA), and (2) the effect of 2'dCPA (20 mg/kg iv) on the central acetylcholine (ACh) release and protection against sarin toxicity. A five-compartment model successfully described the pharmacokinetic profile of 2'dCPA in blood and brain microdialysate. A covariate analysis revealed that the volume of distribution of 2'dCPA in blood was different in sarin-poisoned rats, 177 ± 7 versus 148 ± 8 ml in control rats. However, the transport of 2'dCPA from blood to the brain was unaffected as reflected by the values of the intercompartmental transport clearances, 0.21 ± 0.02 and 0.21 ± 0.04 μl/min in control and sarin-poisoned rats, respectively. Also the area-under-curve (AUC) ratios of brain microdialysate and blood were identical with values of 0.02 ± 0.001 and 0.02 ± 0.002, respectively, demonstrating the restricted transport of 2'dCPA into the brain in both treatment groups. Treatment of sarin-poisoned rats by 2'dCPA did not adequately prevent the accumulation of ACh in the central nervous system. 2'dCPA delayed the emergence of concomitant symptoms compared to untreated rats, but eventually only 29% of the animals survived 24 h. In conclusion, the pharmacokinetic profile of 2'dCPA in blood was slightly changed by sarin, but not the distribution of 2'dCPA into the brain. The therapeutic efficacy of 2'dCPA against sarin was limited, presumably due to insufficient quantities of 2'dCPA reaching the brain

Marcadores para la Realidad Aumentada para fines educativos

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María Reina Zarate Nava

2013-12-01

Full Text Available La Realidad Aumentada (AR es considerada por algunos expertos como la tecnología en crecimiento para el 2014, en diferentes sectores: ingeniería, educación, juegos y negocios, siendo este último el más usado en él 2013. Sin embargo en el sector educativo la AR se presenta en algunos proyectos que se han desarrollado para diferentes áreas de las ciencias, como Química, Física y Matemáticas, lo anterior con el objetivo de facilitar el proceso de Enseñanza-Aprendizaje. En el presente artículo se presenta el modelo de patrones utilizado para un Proyecto AR enfocado en Química, el cual presenta un conjunto de patrones que fueron valorados para facilitar el rastreo de los objetos y a su vez el entendimiento de algunos materiales de los laboratorios de Química I.

Increased Tumor Oxygenation and Drug Uptake During Anti-Angiogenic Weekly Low Dose Cyclophosphamide Enhances the Anti-Tumor Effect of Weekly Tirapazamine

Science.gov (United States)

Doloff, J.C.; Khan, N.; Ma, J.; Demidenko, E.; Swartz, H.M.; Jounaidi, Y.

2010-01-01

Metronomic cyclophosphamide treatment is associated with anti-angiogenic activity and is anticipated to generate exploitable hypoxia using hypoxia-activated prodrugs. Weekly administration of tirapazamine (TPZ; 5 mg/kg body weight i.p.) failed to inhibit the growth of 9L gliosarcoma tumors grown s.c. in scid mice. However, the anti-tumor effect of weekly cyclophosphamide (CPA) treatment (140 mg/kg BW i.p.) was substantially enhanced by weekly TPZ administration. An extended tumor free period and increased frequency of tumor eradication without overt toxicity were observed when TPZ was given 3, 4 or 5 days after each weekly CPA treatment. Following the 2nd CPA injection, Electron Paramagnetic Resonance (EPR) Oximetry indicated significant increases in tumor pO2, starting at 48 hr, which further increased after the 3rd CPA injection. pO2 levels were, however, stable in growing untreated tumors. A strong negative correlation (−0.81) between tumor pO2 and tumor volume during 21 days of weekly CPA chemotherapy was observed, indicating increasing tumor pO2 with decreasing tumor volume. Furthermore, CPA treatment resulted in increased tumor uptake of activated CPA. CPA induced increases in VEGF RNA, which reached a maximum on day 1, and in PLGF RNA which was sustained throughout the treatment, while anti-angiogenic host thrombospondin-1 increased dramatically through day 7 post-CPA treatment. Weekly cyclophosphamide treatment was anticipated to generate exploitable hypoxia. However, our findings suggest that weekly CPA treatment induces a functional improvement of tumor vasculature, which is characterized by increased tumor oxygenation and drug uptake in tumors, thus counter-intuitively, benefiting intratumoral activation of TPZ and perhaps other bioreductive drugs. PMID:19754361

Clinical characteristics of patients with Aspergillus species isolation from respiratory samples: Comparison of chronic pulmonary aspergillosis and colonization.

Science.gov (United States)

Ohara, Sayaka; Tazawa, Yoko; Tanai, Chiharu; Tanaka, Yoshiaki; Noda, Hiromichi; Horiuchi, Hajime; Usui, Kazuhiro

2016-03-01

With advancements in anti-fungal drugs, it has become more important to correctly diagnose chronic pulmonary aspergillosis (CPA); however, it is not easy to distinguish CPA from colonization when Aspergillus species are isolated from respiratory samples. The aim of the study was to clarify the particular clinical characteristics of patients with CPA vs. those with colonization. We retrospectively reviewed the medical records of 110 patients with Aspergillus species isolation from respiratory samples, to analyze and compare the differences between CPA and colonization of the Aspergillus species. The median age of all analyzed was 71 years (range: 31-92 years); 64 were female (58%). The most frequently cultured Aspergillus species was Aspergillus fumigatus (48.3%), followed by A. niger (29.2%). Thirty patients (27.4%) were diagnosed with CPA, vs. 75 (68.2%) with colonization and 5 (4.5%) with allergic bronchopulmonary aspergillosis. Compared with the colonization group, the CPA group included more males (CPA vs. colonization: 49.3% vs. 13.3%) and subjects with a low body mass index (18.45 kg/m2 vs. 21.09 kg/m2). As for the underlying pulmonary diseases, the patients with CPA showed a significantly higher prevalence of sequelae of pulmonary tuberculosis (40% vs. 8%) and a history of thoracic surgery (43% vs. 13%) than those with colonization. Asthma was less frequent in the CPA group than in the colonization group (0% vs. 20%). We found no significantly important underlying extrapulmonary diseases. Patients with CPA display clinical characteristics distinct from those seen in subjects with colonization. Copyright © 2015 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.

Generating para-water from para-hydrogen: A Gedankenexperiment.

Science.gov (United States)

Ivanov, Konstantin L; Bodenhausen, Geoffrey

2018-07-01

A novel conceptual approach is described that is based on the transfer of hyperpolarization from para-hydrogen in view of generating a population imbalance between the two spin isomers of H 2 O. The approach is analogous to SABRE (Signal Amplification By Reversible Exchange) and makes use of the transfer of spin order from para-hydrogen to H 2 O in a hypothetical organometallic complex. The spin order transfer is expected to be most efficient at avoided level crossings. The highest achievable enrichment levels of para- and ortho-water are discussed. Copyright © 2018 Elsevier Inc. All rights reserved.

Cost and performance analysis of conceptual designs of physical protection systems

International Nuclear Information System (INIS)

Hicks, M.J.; Snell, M.S.; Sandoval, J.S.; Potter, C.S.

1998-01-01

CPA -- Cost and Performance Analysis -- is a methodology that joins Activity Based Cost (ABC) estimation with performance based analysis of physical protection systems. CPA offers system managers an approach that supports both tactical decision making and strategic planning. Current exploratory applications of the CPA methodology are addressing analysis of alternative conceptual designs. To support these activities, the original architecture for CPA, is being expanded to incorporate results from a suite of performance and consequence analysis tools such as JTS (Joint Tactical Simulation), ERAD (Explosive Release Atmospheric Dispersion) and blast effect models. The process flow for applying CPA to the development and analysis conceptual designs is illustrated graphically

Conditional Probability Analysis: A Statistical Tool for Environmental Analysis.

Science.gov (United States)

The use and application of environmental conditional probability analysis (CPA) is relatively recent. The first presentation using CPA was made in 2002 at the New England Association of Environmental Biologists Annual Meeting in Newport. Rhode Island. CPA has been used since the...

Uma ferramenta para planejamento de estudos para concursos

Directory of Open Access Journals (Sweden)

Leonardo Pimentel

2015-11-01

Full Text Available De acordo com a constituição brasileira, a única forma de se tornar um empregado do governo é passar em um concurso público. O exame de conhecimento do cargo é um dos componentes mais importantes de um concurso. Estudar para esse exame é uma tarefa que requer planejamento. Um meio de obter um bom planejamento é construir uma grade de horários que relacione as matérias a serem estudadas com os respectivos horários disponíveis para o estudo. Esse tipo de problema se assemelha bastante à gerência de projetos, em que se procura estabelecer a distribuição das atividades ao longo do tempo disponível. Assim, torna-se interessante explorar a dinâmica de estudos para concursos como um projeto. O presente trabalho apresenta a ferramenta de apoio ao estudos - Passe-me, baseada no ciclo PDCA (do inglês, Plan-Do-Check-Act. Por se tratar de uma ferramenta web, o tempo de resposta para produzir uma grade de estudos é fundamental. A ferramenta faz uso de algoritmo genético para calcular a grade de horários priorizando a velocidade de resposta. A ferramenta foi avaliada em diferentes cenários de uso e obteve desempenho satisfatório durante a produção da grade de estudos.

Docencia para el logro y educación para emprender

Directory of Open Access Journals (Sweden)

Luis Gerardo Rodríguez Gómez

1994-05-01

Full Text Available RESUMEN En el primer artículo, el autor plasmó los elementos relevantes para una propuesta de educación para emprender. En este describe el desarrollo docente como expresión de una intensión, saber y un quehacer, encaminados a la formación del hombre emprendedor. El artículo se divide en tres partes. En la primera, se reseña los factores que orientan la intensión docente para emprender, a partir de un discurso y formas metodológicas establecidas con esa intención. En segundo lugar, se asume el espacio y tiempo la clase como unidad de análisis, para lograr objetivos de tipo institucional, programático y temático y en la parte final, se examina la evaluación docente y se hacen consideraciones generales para una propuesta de evaluación,  que surge al investigar la actuación del maestro.

Fabrication of chitosan-g-poly(acrylamide)/CuS nanocomposite for controlled drug delivery and antibacterial activity

Energy Technology Data Exchange (ETDEWEB)

Pathania, Deepak, E-mail: dpathania74@gmail.com [School of Chemistry, Shoolini University of Biotechnology and Management Sciences, Solan, H.P. (India); Gupta, Divya [School of Chemistry, Shoolini University of Biotechnology and Management Sciences, Solan, H.P. (India); Agarwal, Shilpi [Department of Applied Chemistry, University of Johannesburg, Johannesburg (South Africa); Asif, M. [Chemical Engineering Department, King Suad University Riyadh (Saudi Arabia); Gupta, Vinod Kumar [Department of Applied Chemistry, University of Johannesburg, Johannesburg (South Africa); Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667 (India)

2016-07-01

In present study, we reported the synthesis of chitosan-g-poly(acrylamide)/CuS (CPA/CS) nanocomposite for controlled delivery of ofloxacin. The CPA/CS nanocomposites were characterized by Fourier transmission infrared spectroscopy (FTIR), UV–visible spectroscopy (UV), scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis. From the FTIR spectra, the various groups present in CPA/CS nanocomposite were monitored. The homogeneity, morphology and crystallinity of the CPA/CS nanocomposite were ascertained from SEM/EDX and XRD data, respectively. The kinetics of ofloxacin drug delivery was investigated at different pH. The drug released studies were investigated at different pH (2.2, 7.4 and 9.4) and time intervals (2, 4, 6, 8, 10, 12, 14, 16 h). The drug release behavior depends upon the pH of medium and the nature of matrix. The maximum drug loading efficiency of 85% was recorded for CPA/CS. The maximum drug release of 76% was observed at 2.2. pH after 18 h onto CPA/CS. Nanocomposites were also tested for antibacterial activity against Escherichia coli bacteria. About 97% killing of E. coli was observed after 24 h. - Highlights: • Chitosan-g-poly(acrylamide)/CuS (CPA/CS) nanocomposite has been synthesized in microwave reactor. • Different spectral techniques confirmed the formation of nanocomposite. • The drug release behavior of CPA/CS nanocomposites were studied at different pH and different time interval. • CPA/CS has been investigated for an excellent antibacterial activity against E. coli bacterial culture.

Fabrication of chitosan-g-poly(acrylamide)/CuS nanocomposite for controlled drug delivery and antibacterial activity

International Nuclear Information System (INIS)

Pathania, Deepak; Gupta, Divya; Agarwal, Shilpi; Asif, M.; Gupta, Vinod Kumar

2016-01-01

In present study, we reported the synthesis of chitosan-g-poly(acrylamide)/CuS (CPA/CS) nanocomposite for controlled delivery of ofloxacin. The CPA/CS nanocomposites were characterized by Fourier transmission infrared spectroscopy (FTIR), UV–visible spectroscopy (UV), scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis. From the FTIR spectra, the various groups present in CPA/CS nanocomposite were monitored. The homogeneity, morphology and crystallinity of the CPA/CS nanocomposite were ascertained from SEM/EDX and XRD data, respectively. The kinetics of ofloxacin drug delivery was investigated at different pH. The drug released studies were investigated at different pH (2.2, 7.4 and 9.4) and time intervals (2, 4, 6, 8, 10, 12, 14, 16 h). The drug release behavior depends upon the pH of medium and the nature of matrix. The maximum drug loading efficiency of 85% was recorded for CPA/CS. The maximum drug release of 76% was observed at 2.2. pH after 18 h onto CPA/CS. Nanocomposites were also tested for antibacterial activity against Escherichia coli bacteria. About 97% killing of E. coli was observed after 24 h. - Highlights: • Chitosan-g-poly(acrylamide)/CuS (CPA/CS) nanocomposite has been synthesized in microwave reactor. • Different spectral techniques confirmed the formation of nanocomposite. • The drug release behavior of CPA/CS nanocomposites were studied at different pH and different time interval. • CPA/CS has been investigated for an excellent antibacterial activity against E. coli bacterial culture.

Non-Gaussian Systems Control Performance Assessment Based on Rational Entropy

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Jinglin Zhou

2018-05-01

Full Text Available Control loop Performance Assessment (CPA plays an important role in system operations. Stochastic statistical CPA index, such as a minimum variance controller (MVC-based CPA index, is one of the most widely used CPA indices. In this paper, a new minimum entropy controller (MEC-based CPA method of linear non-Gaussian systems is proposed. In this method, probability density function (PDF and rational entropy (RE are respectively used to describe the characteristics and the uncertainty of random variables. To better estimate the performance benchmark, an improved EDA algorithm, which is used to estimate the system parameters and noise PDF, is given. The effectiveness of the proposed method is illustrated through case studies on an ARMAX system.

Kroniske pulmonale aspergilloser

DEFF Research Database (Denmark)

Davidsen, Jesper Rømhild; Rosenvinge, Flemming S; Assing, Kristian

2018-01-01

Chronic pulmonary aspergillosis (CPA) is an overlooked disease category in which delay of diagnosis and treatment is associated with increased mortality. A prerequisite for prognostic optimization of CPA is an increased focus on predisposing factors and patients at risk. Diagnosis of CPA is chall...

The detection of T-Nos, a genetic element present in GMOs, by cross-priming isothermal amplification with real-time fluorescence.

Science.gov (United States)

Zhang, Fang; Wang, Liu; Fan, Kai; Wu, Jian; Ying, Yibin

2014-05-01

An isothermal cross-priming amplification (CPA) assay for Agrobacterium tumefaciens nopaline synthase terminator (T-Nos) was established and investigated in this work. A set of six specific primers, recognizing eight distinct regions on the T-Nos sequence, was designed. The CPA assay was performed at a constant temperature, 63 °C, and detected by real-time fluorescence. The results indicated that real-time fluorescent CPA had high specificity, and the limit of detection was 1.06 × 10(3) copies of rice genomic DNA, which could be detected in 40 min. Comparison of real-time fluorescent CPA and conventional polymerase chain reaction (PCR) was also performed. Results revealed that real-time fluorescent CPA had a comparable sensitivity to conventional real-time PCR and had taken a shorter time. In addition, different contents of genetically modified (GM)-contaminated rice seed powder samples were detected for practical application. The result showed real-time fluorescent CPA could detect 0.5 % GM-contaminated samples at least, and the whole reaction could be finished in 35 min. Real-time fluorescent CPA is sensitive enough to monitor labeling systems and provides an attractive method for the detection of GMO.

Liver collagen in cirrhosis correlates with portal hypertension and liver dysfunction

DEFF Research Database (Denmark)

Nielsen, Kåre; Clemmesen, Jens Otto; Vassiliadis, Efstathios

2014-01-01

livers. In 20 of the livers, CPA was measured in more than one tissue sample. CPA showed significant correlations with HVPG and with various surrogate markers of hepatic dysfunction including albumin, bilirubin, INR, MELD score and Child-Pugh score. CPA reliably discriminated HVPG ≥10 mmHg, termed...

Modelos para estimar consumo e exigências nutricionais para poedeiras comerciais

OpenAIRE

Palma Bendezu, Hilda Cristina [UNESP

2016-01-01

O objetivo deste trabalho foi elaborar um modelo para calcular as ingestões de aminoácidos e energia para a fase de maturação sexual e produção de ovos. As exigências de energia, aminoácidos e consumo de ração foram calculados pelo método fatorial, considerando na fase de maturação sexual a quantidade de nutrientes requerida para mantença e a quantidade de nutrientes necessários para crescimento e deposição de nutrientes corporais em cada componente do corpo (ovário, oviduto, corpo livre de ...

Modeling of the Thermodynamics of the Acetic Acid−Water Mixture Using the Cubic-Plus-Association Equation of State

DEFF Research Database (Denmark)

Breil, Martin Peter; Kontogeorgis, Georgios; Behrens, Paul K.

2011-01-01

The cubic-plus-association (CPA) equation of state is applied in this work to mixtures containing acetic acid and water. A previously developed modification of the model, the so-called CPA-Huron−Vidal (CPA-HV), is used. New CPA parameters have been estimated based on the vapor pressure, liquid...... density, enthalpy of vaporization, and vapor-phase compressibility factor data. The CPA-HV parameters have been fitted to, among others, experimental vapor compressibility factor data and experimental relative volatility data at different temperature ranges. The purpose of the work was to investigate...... that satisfactory results are overall obtained, but if an excellent match is needed over the whole temperature range, then different interaction parameters need to be used at the various temperature ranges....

Análisis de la biomecánica de la marcha en mujeres con hipertrofia mamaria

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G.R. Schütz

2013-12-01

Full Text Available La hipertrofia mamaria se define como un aumento anormal de las mamas y provoca en las mujeres que la padecen diversas adaptaciones en la marcha y en el equilibrio. El objetivo de este trabajo es llevar a cabo un análisis de las características cinéticas y cinemáticas de la marcha en las mujeres con hipertrofia mamaria. Participan en nuestro estudio 13 mujeres con hipertrofia mamaria. Empleamos una plataforma de fuerza para medir el componente vertical de la marcha y analizamos diversas variables: primer pico de fuerza (PPF, segundo pico de fuerza (SPF, tasa de aceptación de peso (TAP y fuerza de apoyo media (SMF. Para el análisis cinemático empleamos dos cámaras filmadoras (30 Hz, analizando las siguientes variables espacio-temporales: TAS (tiempo de apoyo simple derecho e izquierdo, TDA (tiempo de doble apoyo, TTP (tiempo total del paso, TA y TB (tiempo de apoyo y equilibro, CPO (longitud del paso a derecha e izquierda, CPA (longitud de la zancada, LPO (anchura de la zancada y v (velocidad de desplazamiento. Encontramos que las variables cinéticas PPF, SPF y TAP y las variables espacio-temporales TDA, TA, TB, CPO, CPA, LPO y v, presentaron valores diferentes de los considerados como normales para mujeres de la misma franja de edad. Creemos por tanto que las mujeres analizadas se desplazan más lentamente, con pasos más cortos y más anchos, lo que genera un tiempo mayor de contacto del peso con el pie plano en el apoyo inicial. Como conclusión podemos establecer que la marcha en las mujeres con hipertrofia mamaria presenta características que la hacen diferente de los patrones biomecánicos presentes en las mujeres que no la padecen para la misma franja de edad, características que la hacen semejante a la de las mujeres obesas.

Modelos para estimar as exigências de energia metabolizável para poedeiras

OpenAIRE

Sakomura,Nilva Kazue; Basaglia,Roberta; Sá-Fortes,Cristina M. L.; Fernandes,João Batista K.

2005-01-01

Objetivou-se, com este trabalho, elaborar um modelo para estimar as exigências de energia metabolizável (EM) para poedeiras leves da linhagem Lohmann LSL, utilizando-se o método fatorial. Para determinar o efeito da temperatura sobre as exigências de EM para mantença, foram conduzidos experimentos em câmaras climáticas com temperaturas constantes de 12, 22 e 31ºC, utilizando a técnica do abate comparativo. A exigência de energia líquida para o ganho de peso foi determinada por meio da regress...

The use of cyproterone acetate in a forensic psychiatric cohort of male sex offenders and its associations with sexual activity and sexual functioning

Directory of Open Access Journals (Sweden)

Gian Lippi

2017-03-01

Full Text Available Background: Cyproterone acetate (CPA is a steroidal anti-androgenic medication used in the field of psychiatry for the treatment of paraphilic disorders, hypersexuality, and inappropriate sexual behaviour which may be present in patients with disorders such as mild and major neurocognitive disorders. In the forensic psychiatric population, it is prescribed for these indications especially for patients with a history of committing a sexual offence or who are at moderate to high risk of recidivism. Objectives: To investigate the use of CPA in a forensic psychiatric cohort of male sex offenders and its associations with sexual activity and sexual functioning. Methods: Seventy-six forensic psychiatric patients from Weskoppies Hospital in Pretoria, South Africa, participated in the study which measured their sexual functioning. A specifically designed questionnaire was used to capture relevant background information. The use of CPA was studied. The Changes in Sexual Functioning Questionnaire, Male Clinical Version (CSFQ-M-C was used to measure sexual functioning of participants. The CSFQ-M-C scores, and those of all its subscales, of participants on CPA were compared to those not on the drug. Relevant statistical analyses were performed. Results: Thirteen out of the 76 participants were being treated with CPA (17.11%. In total, 53.85% of the participants on CPA and 65.08% not on CPA had scores indicating the presence of sexual dysfunction. The total CSFQ-M-C scores for participants on CPA (mean = 40.54; median = 42 were not statistically significantly lower than those not on the drug (mean = 41.22; median = 41. More notable is that the use of CPA in this population was associated with lower levels of desire, frequency of and pleasure from sexual activity. There was an association between having intellectual disability and being treated with CPA. Conclusion: That all the participants were being treated with psychotropic medication could account for

Phase Equilibria of Mixtures Containing Organic Sulfur Species (OSS) and Water/Hydrocarbons: VLE Measurements and Modeling Using the Cubic-Plus-Association Equation of State

DEFF Research Database (Denmark)

Awan, Javeed; Tsivintzelis, Ioannis; Breil, Martin

2010-01-01

with the cubic-plus-association (CPA) equation of state. Useful remarks are presented about the application of Henry’s constant values to estimate binary interaction parameters of the CPA EoS for the description of whole vapor−liquid equilibria. The results using CPA EoS show that the cross association...

Improving cardiopulmonary resuscitation with a CPR feedback device and refresher simulations (CPR CARES Study): a randomized clinical trial.

Science.gov (United States)

Cheng, Adam; Brown, Linda L; Duff, Jonathan P; Davidson, Jennifer; Overly, Frank; Tofil, Nancy M; Peterson, Dawn T; White, Marjorie L; Bhanji, Farhan; Bank, Ilana; Gottesman, Ronald; Adler, Mark; Zhong, John; Grant, Vincent; Grant, David J; Sudikoff, Stephanie N; Marohn, Kimberly; Charnovich, Alex; Hunt, Elizabeth A; Kessler, David O; Wong, Hubert; Robertson, Nicola; Lin, Yiqun; Doan, Quynh; Duval-Arnould, Jordan M; Nadkarni, Vinay M

2015-02-01

The quality of cardiopulmonary resuscitation (CPR) affects hemodynamics, survival, and neurological outcomes following pediatric cardiopulmonary arrest (CPA). Most health care professionals fail to perform CPR within established American Heart Association guidelines. To determine whether "just-in-time" (JIT) CPR training with visual feedback (VisF) before CPA or real-time VisF during CPA improves the quality of chest compressions (CCs) during simulated CPA. Prospective, randomized, 2 × 2 factorial-design trial with explicit methods (July 1, 2012, to April 15, 2014) at 10 International Network for Simulation-Based Pediatric Innovation, Research, & Education (INSPIRE) institutions running a standardized simulated CPA scenario, including 324 CPR-certified health care professionals assigned to 3-person resuscitation teams (108 teams). Each team was randomized to 1 of 4 permutations, including JIT training vs no JIT training before CPA and real-time VisF vs no real-time VisF during simulated CPA. The proportion of CCs with depth exceeding 50 mm, the proportion of CPR time with a CC rate of 100 to 120 per minute, and CC fraction (percentage CPR time) during simulated CPA. The quality of CPR was poor in the control group, with 12.7% (95% CI, 5.2%-20.1%) mean depth compliance and 27.1% (95% CI, 14.2%-40.1%) mean rate compliance. JIT training compared with no JIT training improved depth compliance by 19.9% (95% CI, 11.1%-28.7%; P 89.0%) in all groups. Combining both interventions showed the highest compliance with American Heart Association guidelines but was not significantly better than either intervention in isolation. The quality of CPR provided by health care professionals is poor. Using novel and practical technology, JIT training before CPA or real-time VisF during CPA, alone or in combination, improves compliance with American Heart Association guidelines for CPR that are associated with better outcomes. clinicaltrials.gov Identifier: NCT02075450.

Significados da gravidez e da maternidade: discursos de primíparas e multíparas

OpenAIRE

Silva, Flavia Baroni; Souza, Laura Vilela e; Scorsolini-Comin, Fabio

2013-01-01

Resumo: O objetivo foi compreender os sentidos sobre maternidade e as vivências da gravidez em gestantes primíparas e multíparas. Foram entrevistadas seis gestantes, sendo três primíparas e três multíparas. Nas falas, foram trazidos temas como dificuldades físicas, alterações corporais, repercussão da gravidez no relacionamento conjugal, planejamento da gravidez e envolvimento paterno. Observou-se, nas primíparas, que a inexperiência trouxe insegurança, ao passo que, em algumas multíparas, ho...

Estrategias para negociaciones exitosas.

OpenAIRE

José B. Parra V; Evelinda Santiago J.; Misael Murillo M.; Candy Atonal N.

2010-01-01

Las estrategias de negociación son herramientas para disminuir conflictos o para intercambiar bienes y servicios. Una negociación exitosa crea relaciones de solidaridad y propicia reciprocidad, cooperación y confianza para quienes tendrán relaciones permanentes de negociación con beneficios para ambas partes. Una estrategia de negociación exitosa requiere manejar el desarrollo del ambiente social del grupo de personas, con la finalidad de tener presente las fronteras que no pueden irrumpirse....

Simple Response Surface Methodology: Investigation on Advance Photocatalytic Oxidation of 4-Chlorophenoxyacetic Acid Using UV-Active ZnO Photocatalyst.

Science.gov (United States)

Lee, Kian Mun; Hamid, Sharifah Bee Abd

2015-01-19

The performance of advance photocatalytic degradation of 4-chlorophenoxyacetic acid (4-CPA) strongly depends on photocatalyst dosage, initial concentration and initial pH. In the present study, a simple response surface methodology (RSM) was applied to investigate the interaction between these three independent factors. Thus, the photocatalytic degradation of 4-CPA in aqueous medium assisted by ultraviolet-active ZnO photocatalyst was systematically investigated. This study aims to determine the optimum processing parameters to maximize 4-CPA degradation. Based on the results obtained, it was found that a maximum of 91% of 4-CPA was successfully degraded under optimal conditions (0.02 g ZnO dosage, 20.00 mg/L of 4-CPA and pH 7.71). All the experimental data showed good agreement with the predicted results obtained from statistical analysis.

Cerebellopontine angle medulloblastoma with extensive nodularity in a child: case report and review of the literature.

Science.gov (United States)

Noiphithak, Raywat; Yindeedej, Vich; Thamwongskul, Chatchai

2017-05-01

Cerebellar medulloblastomas (MBs) are one of the most common posterior fossa tumors in children but rarely occur in the cerebellopontine angle (CPA). Only 39 cases of CPA MBs were reported in the literature, and most of them were classic and desmoplastic MBs. A 22-month-old girl presented with progressive cerebellar ataxia. Magnetic resonance imaging showed a large tumor in the right CPA and obstructive hydrocephalus. Surgical resection was performed and achieved total tumor removal. Microscopic examination and immunohistochemical staining revealed the diagnosis of MB with extensive nodularity. The patient recovered from her symptoms during follow-up and was transferred for adjuvant chemotherapy. MB should be considered as a differential diagnosis of a lesion in the CPA. The treatment and outcome of CPA MBs are similar to cerebellar MBs.

Cyclopiazonic acid biosynthesis in Aspergillus sp.: characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan.

Science.gov (United States)

Liu, Xinyu; Walsh, Christopher T

2009-09-15

The fungal neurotoxin alpha-cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca2+-ATPase, has a pentacyclic indole tetramic acid scaffold that arises from one molecule of tryptophan, acetyl-CoA, malonyl-CoA, and dimethylallyl pyrophosphate by consecutive action of three enzymes, CpaS, CpaD, and CpaO. CpaS is a hybrid, two module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) that makes and releases cyclo-acetoacetyl-L-tryptophan (cAATrp), the tetramic acid that serves as substrate for subsequent prenylation and oxidative cyclization to the five ring CPA scaffold. The NRPS module in CpaS has a predicted four-domain organization of condensation, adenylation, thiolation, and reductase* (C-A-T-R*), where R* lacks the critical Ser-Tyr-Lys catalytic triad of the short chain dehydrogenase/reductase (SDR) superfamily. By heterologous overproduction in Escherichia coli of the 56 kDa Aspergillus flavus CpaS TR* didomain and the single T and R* domains, we demonstrate that CpaS catalyzes a Dieckmann-type cyclization on the N-acetoacetyl-Trp intermediate bound in thioester linkage to the phosphopantetheinyl arm of the T domain to form and release cAATrp. This occurs without any participation of NAD(P)H, so R* does not function as a canonical SDR family member. Use of the T and R* domains in in trans assays enabled multiple turnovers and evaluation of specific mutants. Mutation of the D3803 residue in the R* domain, conserved in other fungal tetramate synthetases, abolished activity both in in trans and in cis (TR*) activity assays. It is likely that cyclization of beta-ketoacylaminoacyl-S-pantetheinyl intermediates to released tetramates represents a default cyclization/release route for redox-incompetent R* domains embedded in NRPS assembly lines.

Molecular cloning and immunochemical characterization of a novel major Japanese cedar pollen allergen belonging to the aspartic protease family.

Science.gov (United States)

Ibrahim, Ahmed Ragaa Nour; Kawamoto, Seiji; Aki, Tsunehiro; Shimada, Yayoi; Rikimaru, Satoshi; Onishi, Nobukazu; Babiker, Elfadil Elfadl; Oiso, Isao; Hashimoto, Kunihiko; Hayashi, Takaharu; Ono, Kazuhisa

2010-01-01

Japanese cedar (Cryptomeria japonica) pollen is a major cause of seasonal pollinosis in Japan. Protease activity in the pollen grains may trigger pro-allergic responses but no such proteases have yet been identified as pollen allergens. We report the molecular cloning and immunochemical characterization of a novel C. japonica pollen allergen belonging to the aspartic protease family. We focused on the C. japonica pollen allergen spot No. 63 (CPA63, 47.5% IgE binding frequency) on our 2-dimensional IgE immunoblot map. The internal amino acid sequences were determined using time-of-flight mass spectrometry. Full-length cpa63 cDNA was cloned by rapid amplification of cDNA ends (RACE)-PCR. Recombinant CPA63 (r-CPA63) was expressed using the baculovirus-insect cell culture system and its IgE binding capacity was analyzed by enzyme-linked immunosorbent assay (ELISA). The proteolytic activity of r-CPA63 was also assessed using a putative mature enzyme produced upon autolysis. cpa63 cDNA encoded a 472 amino acid polypeptide showing about 40% sequence identity to members of the plant atypical aspartic protease family. ELISA showed that r-CPA63 was recognized by IgE antibodies in the serum of 58% (18/31) of Japanese cedar pollinosis patients. We also demonstrated an aspartic protease-like enzyme activity of the putative mature r-CPA63. We have identified the first plant aspartic protease allergen from Japanese cedar pollen. The availability of the CPA63 sequence and its recombinant allergen production system are useful not only for pharmaceutical applications but also for further examination of the role of protease activity in the pathogenesis of cedar pollinosis. 2010 S. Karger AG, Basel.

The Influence of the Consumer Protection Act 68 of 2008 on the ...

African Journals Online (AJOL)

The implementation of the Consumer Protection Act 68 of 2008 (CPA) has great implications for the South African common law of sale. In this contribution the influence of the CPA on the seller's common law duty to warrant the buyer against eviction is investigated. Upon evaluation of the relevant provisions of the CPA, the ...

Critical coupling and coherent perfect absorption for ranges of energies due to a complex gain and loss symmetric system

International Nuclear Information System (INIS)

Hasan, Mohammad; Ghatak, Ananya; Mandal, Bhabani Prasad

2014-01-01

We consider a non-Hermitian medium with a gain and loss symmetric, exponentially damped potential distribution to demonstrate different scattering features analytically. The condition for critical coupling (CC) for unidirectional wave and coherent perfect absorption (CPA) for bidirectional waves are obtained analytically for this system. The energy points at which total absorption occurs are shown to be the spectral singular points for the time reversed system. The possible energies at which CC occurs for left and right incidence are different. We further obtain periodic intervals with increasing periodicity of energy for CC and CPA to occur in this system. -- Highlights: •Energy ranges for CC and CPA are obtained explicitly for complex WS potential. •Analytical conditions for CC and CPA for PT symmetric WS potential are obtained. •Conditions for left and right CC are shown to be different. •Conditions for CC and CPA are shown to be that of SS for the time reversed system. •Our model shows the great flexibility of frequencies for CC and CPA

Genome-wide identification and comparative analysis of the cation proton antiporters family in pear and four other Rosaceae species.

Science.gov (United States)

Zhou, Hongsheng; Qi, Kaijie; Liu, Xing; Yin, Hao; Wang, Peng; Chen, Jianqing; Wu, Juyou; Zhang, Shaoling

2016-08-01

The monovalent cation proton antiporters (CPAs) play essential roles in plant nutrition, development, and signal transduction by regulating ion and pH homeostasis of the cell. The CPAs of plants include the Na(+)/H(+) exchanger, K(+) efflux antiporter, and cation/H(+) exchanger families. However, currently, little is known about the CPA genes in Rosaceae species. In this study, 220 CPA genes were identified from five Rosaceae species (Pyrus bretschneideri, Malus domestica, Prunus persica, Fragaria vesca, and Prunus mume), and 53 of which came from P. bretschneideri. Phylogenetic, structure, collinearity, and gene expression analyses were conducted on the entire CPA genes of pear. Gene expression data showed that 35 and 37 CPA genes were expressed in pear fruit and pollen tubes, respectively. The transcript analysis of some CPA genes under abiotic stress conditions revealed that CPAs may play an important role in pollen tubes growth. The results presented here will be useful in improving understanding of the complexity of the CPA gene family and will promote functional characterization in future studies.

Rapid on-site detection of Acidovorax citrulli by cross-priming amplification.

Science.gov (United States)

Zhang, Jing; Tian, Qian; Zhu, Shui-fang; Zhao, Wen-jun; Liu, Feng-quan

2012-08-01

Cross-priming amplification (CPA) for Acidovorax citrulli detection was evaluated in this study. The sensitivity of CPA assay for pure bacterial culture was 3.7 × 10(3) CFU/ml. Bacteria on naturally infected watermelon seeds were detected using CPA assay, suggesting this method is suitable for A. citrulli on-site detection from watermelon seeds. Copyright © 2012 Elsevier Ltd. All rights reserved.

Dental health care providers' views on child physical abuse in Malaysia.

Science.gov (United States)

Hussein, A S; Ahmad, R; Ibrahim, N; Yusoff, A; Ahmad, D

2016-10-01

To assess the knowledge, attitudes and experience of a group of Malaysian dental health care providers regarding child physical abuse (CPA) cases in terms of frequency of occurrence, diagnosis, risk factors and reporting. A questionnaire was distributed to all dental health care providers attending a national paediatric dentistry conference in Kuantan, Malaysia, and demographical variables, knowledge, attitudes and experience about CPA, risk factors and the reasons for not reporting abuse cases were collected. Descriptive statistics and bivariance analysis were performed. A 5 % level of statistical significance was applied for the analyses (p ≤ 0.05). The response rate was 74.7 %. Half of the respondents (52.8 %) stated that the frequency of occurrence of CPA is common in Malaysia. Full agreement between dental health care providers was not determined concerning the identification of signs of CPA and its risk factors. Although 83.3 % were aware that reporting CPA is a legal requirement in Malaysia, only 14.8 % have reported such cases. Lack of adequate history was the main reason for not reporting. Virtually two-thirds of the respondents (62 %) indicated that they had not received sufficient information about CPA and were willing to be educated on how to diagnose and report child abuse cases (81.5, 78.7 %, respectively). There were considerable disparities in respondents' knowledge and attitudes regarding the occurrence, signs of suspected cases, risk factors and reporting of CPA. Despite being aware of such cases, only a handful was reported. Enhancement in the education of Malaysian dental health care providers on recognising and reporting CPA is recommended.

The Word Game: an innovative strategy for assessing implicit processes in parents at risk for child physical abuse.

Science.gov (United States)

Crouch, Julie L; Irwin, Lauren M; Wells, Brett M; Shelton, Christopher R; Skowronski, John J; Milner, Joel S

2012-06-01

Contemporary theories of child physical abuse (CPA) emphasize the proximal role of social cognitive processes (many of which are implicit in nature) in the occurrence of parental aggression. However, methods that allow for the systematic examination of implicit cognitive processes during the course of aggressive interactions are needed. To address this need, the present study was designed to examine the utility of the Word Game, an innovative procedure designed to assess implicit changes in schema accessibility during the course of an interpersonal exchange involving aggressive response options. The game involves a series of competitive reaction time trials which are actually lexical decision making trials designed to determine the accessibility of schema throughout the game. Each parent was led to believe that they were competing against another player with whom they exchanged sound blasts of varying intensities. Participants in the present study were parents who were either low (n=50) or high (n=20) risk for CPA. Results revealed that high CPA risk parents behaved more aggressively than low CPA risk parents and that provocation augmented the aggressiveness of all participants. Among high CPA risk parents, positive schema became less accessible (whereas negative schema became more accessible) following lost rounds. At the conclusion of the game, high CPA risk parents reported more aggressive motives than low CPA risk parents. Further, aggressive motives significantly mediated the association between CPA risk status and aggressiveness (i.e., mean sound blast selections). Collectively, results support the potential utility of the Word Game as a means of advancing the study of social cognitive processes involved in parental aggression. Published by Elsevier Ltd.

Para-equilibrium phase diagrams

International Nuclear Information System (INIS)

Pelton, Arthur D.; Koukkari, Pertti; Pajarre, Risto; Eriksson, Gunnar

2014-01-01

Highlights: • A rapidly cooled system may attain a state of para-equilibrium. • In this state rapidly diffusing elements reach equilibrium but others are immobile. • Application of the Phase Rule to para-equilibrium phase diagrams is discussed. • A general algorithm to calculate para-equilibrium phase diagrams is described. - Abstract: If an initially homogeneous system at high temperature is rapidly cooled, a temporary para-equilibrium state may result in which rapidly diffusing elements have reached equilibrium but more slowly diffusing elements have remained essentially immobile. The best known example occurs when homogeneous austenite is quenched. A para-equilibrium phase assemblage may be calculated thermodynamically by Gibbs free energy minimization under the constraint that the ratios of the slowly diffusing elements are the same in all phases. Several examples of calculated para-equilibrium phase diagram sections are presented and the application of the Phase Rule is discussed. Although the rules governing the geometry of these diagrams may appear at first to be somewhat different from those for full equilibrium phase diagrams, it is shown that in fact they obey exactly the same rules with the following provision. Since the molar ratios of non-diffusing elements are the same in all phases at para-equilibrium, these ratios act, as far as the geometry of the diagram is concerned, like “potential” variables (such as T, pressure or chemical potentials) rather than like “normal” composition variables which need not be the same in all phases. A general algorithm to calculate para-equilibrium phase diagrams is presented. In the limit, if a para-equilibrium calculation is performed under the constraint that no elements diffuse, then the resultant phase diagram shows the single phase with the minimum Gibbs free energy at any point on the diagram; such calculations are of interest in physical vapor deposition when deposition is so rapid that phase

Does accessibility of positive and negative schema vary by child physical abuse risk?

Science.gov (United States)

Crouch, Julie L; Risser, Heather J; Skowronski, John J; Milner, Joel S; Farc, Magdalena M; Irwin, Lauren M

2010-11-01

To examine differences in accessibility of positive and negative schema in parents with high and low risk for child physical abuse (CPA). This study combined picture priming and lexical decision making methods to assess the accessibility of positive and negative words following presentation of child and adult faces. The child and adult faces depicted positive, ambiguous, and negative affective valences. The sample included 67 (51 low and 16 high CPA risk) general population parents. CPA risk status was associated with accessibility of positive/negative words only following priming with faces of the opposite affective valence. More specifically, high CPA risk parents were slower to respond to positive (negative) words following priming with negative (positive) faces. Exploratory analyses indicated that this pattern of findings was more clearly apparent when picture primes involved adult faces. The present findings suggest that high and low CPA risk parents differ in how they process affectively incongruent information. Research is needed to further examine schema accessibility, as well as to examine whether processes involved in attention and affect integration play a role in CPA risk. Copyright © 2010 Elsevier Ltd. All rights reserved.

Study of the Relationship between Taste Sensor Response and the Amount of Epigallocatechin Gallate Adsorbed Onto a Lipid-Polymer Membrane

Directory of Open Access Journals (Sweden)

Yuhei Harada

2015-03-01

Full Text Available A taste sensor using lipid-polymer membranes has been developed to evaluate the taste of foods, beverages and medicines. The response of the taste sensor, measured as a change in the membrane potential caused by adsorption (CPA, corresponds to the aftertaste felt by humans. The relationships between the CPA value and the amount of adsorbed taste substances, quinine and iso-α acid (bitterness, and tannic acid (astringency, have been studied so far. However, that of epigallocatechin gallate (EGCg has not been clarified, although EGCg is abundantly present in green tea as one of its astringent substances. This study aimed at clarifying the response of the taste sensor to EGCg and its relationship with the amount of EGCg adsorbed onto lipid-polymer membranes. The lipid concentration dependence of the CPA value was similar to that of the amount of adsorbed EGCg, indicating a high correlation between the CPA value and the amount of adsorbed EGCg. The CPA value increased with increasing amount of adsorbed EGCg; however, the CPA value showed a tendency of leveling off when the amount of adsorbed EGCg further increased.

Lattice vibrations in K/sub c/Rb/sub 1-c/ alloys

International Nuclear Information System (INIS)

Kaplan, T.; Mostoller, M.; Gray, L.J.

1985-01-01

The authors have already studied this system theoretically using the mass defect coherent potential approximation (CPA) and the CPA-F. The deficiencies in the mass defect CPA and CPA-F theories have led them to apply a more sophisticated approximation which was developed by Kaplan, Leath, Gray and Diehl (KLGD). This approximation is a generalization of the CPA which is not restricted to single site averaging, but can include cluster scattering. More important, it can incorporate force constant changes without any restrictions. As a first application of KLGD, they have included nearest neighbor radial and tangential force constant changes with single site averaging. As in the previous cases, all longer range forces are included in a virtual crystal approximation. In this study they have not tried to fit the force constants. Instead they have used a pseudopotential approximation by Gruenewald and Scharnberg to determine the force constants in K-Rb alloys

Cerebellopontine angle lipomas: magnetic resonance imaging findings in two cases

Energy Technology Data Exchange (ETDEWEB)

Borges, Rafael S. [Clinica de Diagnostico por Imagem Multi-Imagem, Rio de Janeiro, RJ (Brazil); Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Dept. de Radiologia; Brito, Cecilia Castelo Branco [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Fac. de Medicina; Carvalho, Gustavo A. [Clinica Bambina, Rio de Janeiro, RJ (Brazil). Dept. de Neurocirurgia; Hospital Silvestre, Rio de Janeiro, RJ (Brazil); Domingues, Romeu C. [Clinicas CDPI e Multi-Imagem, Rio de Janeiro RJ (Brazil); Gasparetto, Emerson L. [Clinicas CDPI e Multi-Imagem, Rio de Janeiro RJ (Brazil)

2009-07-01

Vestibular schwannomas and meningiomas are the most common lesions of the cerebellopontine angle (CPA), accounting for approximately 85-90% of the tumors seen in this location. Lipomas are rare at this topography, representing about 0.15% of the CPA lesions. These tumors are mal developmental masses that arise from abnormal differentiation of the meninx primitive. Clinically, CPA lipomas can cause slowly progressive neurological symptoms and signs affecting cranial nerves or brain stem. Because these lesions usually are strongly attached to the surrounding structures, any surgical attempts of complete resection can result in neural or vascular damage, reinforcing the importance of the pre-operative imaging diagnosis. Although the CT findings of CPA lipomas can be typical, the magnetic resonance (MR) imaging, especially the fat suppression sequences, had improved the identification of these lesions. We aimed to report two patients with a CPA lipoma, emphasizing the MR imaging findings. (author)

Cerebellopontine angle lipomas: magnetic resonance imaging findings in two cases

International Nuclear Information System (INIS)

Borges, Rafael S.; Domingues, Romeu C.; Gasparetto, Emerson L.

2009-01-01

Vestibular schwannomas and meningiomas are the most common lesions of the cerebellopontine angle (CPA), accounting for approximately 85-90% of the tumors seen in this location. Lipomas are rare at this topography, representing about 0.15% of the CPA lesions. These tumors are mal developmental masses that arise from abnormal differentiation of the meninx primitive. Clinically, CPA lipomas can cause slowly progressive neurological symptoms and signs affecting cranial nerves or brain stem. Because these lesions usually are strongly attached to the surrounding structures, any surgical attempts of complete resection can result in neural or vascular damage, reinforcing the importance of the pre-operative imaging diagnosis. Although the CT findings of CPA lipomas can be typical, the magnetic resonance (MR) imaging, especially the fat suppression sequences, had improved the identification of these lesions. We aimed to report two patients with a CPA lipoma, emphasizing the MR imaging findings. (author)

Development of a Collaborative Practice Agreement Template to Promote the Role of the Pharmacist in Managing Urinary Tract Infections in Long-term Care Residents

Science.gov (United States)

Fehrenbacher, Lynne; McDevitt, Kimberly; Palmer, Matthew; Traynor, Laura; Boero, Joe; Crnich, Christopher

2017-01-01

Abstract Background One of the CDC core elements of antimicrobial stewardship in nursing homes emphasizes the promotion of clinical practice change and integration of the dispensing and consultant pharmacist to improve antibiotic use. An opportunity to support this element is via collaborative practice agreements (CPA). A CPA is a voluntary agreement between one or more prescribers and pharmacists which delegates physician authority under defined conditions and/or limitations toward a common goal. The Wisconsin Healthcare-Associated Infections (HAI) in Long-term Care (LTC) Coalition aims to reduce and eliminate HAIs among LTC residents. A coalition emphasis has been to educate caregivers about appropriate evaluation and treatment of suspected urinary tract infection (UTI). Given this focus, we targeted the same cohort for CPA design. Methods A literature review resulted in no report of CPAs being applied to LTC residents on antibiotics for UTI. Recognizing the dispensing and consultant pharmacist role varies by organization, we drafted a multi-layered CPA that can be customized by facility. The draft was reviewed by physicians, pharmacists, and nurses with expertise in infectious diseases, LTC, and CPAs. Through frequent meetings and collaborative editing, consensus was achieved. The final CPA includes antibiotic renal dose adjustment, discontinuation of antibiotics in asymptomatic patients with negative urinalysis or culture, and oral antibiotic modification based on organism susceptibility. Results The CPA template is supported by the WI HAI in LTC Coalition. It has been presented at the state level and is available for use by LTC facilities and pharmacists that may apply any/all level(s) of the CPA. An organization policy template and initial CPA competency for pharmacists have been designed to support implementation. Committed pilot sites have been identified. Conclusion A CPA is an innovative approach to expand the role of the dispensing and consultant

Estrategia para elevar la motivación laboral; factor imprescindible para mejorar nuestra productividad.

OpenAIRE

Reina de los Ángeles Carballé Piñón

2015-01-01

Este trabajo "Estrategia para elevar la motivación laboral; factor imprescindible para mejorar nuestra productividad" resulta de la investigación realizada para tesis de maestría; se realizó el estudio de 2 entidades, nos permitió conocer las principales posiciones que sobre motivación existen, factores que la influencian, cómo incide en el desempeño laboral y que acciones diseñar para elevarla. Las 2 entidades seleccionadas, claves en el desempeño empresarial son un centro de interfase y un...

Estrategias para negociaciones exitosas.

Directory of Open Access Journals (Sweden)

José B. Parra V

2010-01-01

Full Text Available Las estrategias de negociación son herramientas para disminuir conflictos o para intercambiar bienes y servicios. Una negociación exitosa crea relaciones de solidaridad y propicia reciprocidad, cooperación y confianza para quienes tendrán relaciones permanentes de negociación con beneficios para ambas partes. Una estrategia de negociación exitosa requiere manejar el desarrollo del ambiente social del grupo de personas, con la finalidad de tener presente las fronteras que no pueden irrumpirse. Otro aspecto importante, es el lenguaje corporal utilizado por las personas y las tácticas que se practican. El manejo de esta información permite diseñar diferentes modelos de negociaciones para cada caso específico. Este documento propone la utilización de la herramienta MONACO, diseñada por los autores, que es un software útil para encontrar los mejores tácticas posibles dentro de una negociación; basándose en el lenguaje corporal que muestra el negociante oponente durante cada oferta monetaria. El uso de este software da al negociador la oportunidad de manejar las negociaciones con mayor control, el negociador que usa el software puede elegir una estrategia de acuerdo a las relaciones que espera mantener con el negociador oponente.

The implementation of the Care Programme Approach for service users with a learning disability. Building Bridges to the same Old Horizons?

Science.gov (United States)

Kelly, M

2017-08-01

WHAT IS KNOWN ON THE SUBJECT?: People with mental health problems and learning disabilities often do not receive the care they require. The Care Programme Approach (CPA) is meant to help with this. However, there have been many problems in the past with the introduction of the CPA into mental health services. There is no literature which explores what factors help or hinder the introduction of the CPA for service users with a mental health and learning disability, especially from the perspective of those responsible for overseeing this process. WHAT DOES THIS ARTICLE ADD TO EXISTING KNOWLEDGE?: The implementation of the CPA for this service user group is fragmented, and services are not working together in partnership. The CPA is being effectively implemented for people who are deemed to present with a risk to themselves or others. If a service user does not present with a high risk, they are not provided care through the CPA. Service users were not involved in the development or introduction of the policy in practice. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Services need to work better at engaging service users when they are developing and introducing new policies. Rather than applying the CPA for all service users, across all services, it should only be considered for those deemed to present with a high risk. It is effectively implemented for these people. For those not deemed to present with a high risk, services should consider using alternative service user led care planning frameworks. Introduction The Care Programme Approach was introduced in England to ensure services met the needs of people with mental health problems and a concurrent learning disability (dual diagnosis). The CPA implementation was patchy and services failed to work in partnership. Aim This study aimed to explore the factors shaping the recent implementation of the CPA for service users with a dual diagnosis. Method A single case study approach was undertaken. Data were collected through

Comparison of Cole-Cole and Constant Phase Angle modeling in time-domain induced polarization

DEFF Research Database (Denmark)

Lajaunie, Myriam; Maurya, Pradip Kumar; Fiandaca, Gianluca

The Cole-Cole model and the constant phase angle (CPA) model are two prevailing phenomenological descriptions of the induced polarization (IP), used for both frequency domain (FD) and time domain (TD) modeling. The former one is a 4-parameter description, while the latest one involves only two......, forward modeling of quadrupolar sequences on 1D and 2D heterogeneous CPA models shows that the CPA decays differ among each other only by a multiplication factor. Consequently, the inspection of field data in log-log plots gives insight on the modeling needed for fitting them: the CPA inversion cannot...... is reflected in TDIP data, and therefore, at identifying (1) if and when it is possible to distinguish, in time domain, between a Cole-Cole description and a CPA one, and (2) if features of time domain data exist in order to know, from a simple data inspection, which model will be the most adapted to the data...

Simultaneous realization of a coherent perfect absorber and laser by zero-index media with both gain and loss

KAUST Repository

Bai, Ping

2016-12-20

We investigate a unique type of zero-index medium with both gain and loss (ZIMGL), whose effective permittivity and permeability are both purely imaginary but of opposite signs. We analytically show that, by using a slab of ZIMGL with equal magnitude of loss and gain, simulation realization of a coherent perfect absorber (CPA) and laser, i.e., the so-called CPA laser, can be achieved. Previously the CPA laser was proposed in parity-time (PT) symmetric systems. However, the ZIMGL does not possess the PT symmetry and thus the underlying physics is distinctly different. By designing a photonic crystal (PC) composed of core-shell rods, with loss and gain distributed in either the core or the shell, we have realized such a ZIMGL. The CPA-laser functionality of such a PC is also confirmed in our numerical simulations. Our work provides a different approach for simultaneous realization of CPA and laser besides PT-symmetric systems.

Inhibition of neurotensin-stimulated mast cell secretion and carboxypeptidase A activity by the peptide inhibitor of carboxypeptidase A and neurotensin-receptor antagonist SR 48692.

Science.gov (United States)

Miller, L A; Cochrane, D E; Feldberg, R S; Carraway, R E

1998-06-01

Neurotensin (NT), a peptide found in brain and several peripheral tissues, is a potent stimulus for mast cell secretion and its actions are blocked by the specific NT receptor antagonist, SR 48692. Subsequent to stimulation, NT is rapidly degraded by mast cell carboxypeptidase A (CPA). In the experiments described here, we tested for the involvement of CPA activity in the activation of mast cell secretion by the peptide, NT. Mast cells were isolated from the peritoneal and pleural cavities of rats, purified over metrizamide gradients and incubated at 37 degrees C in Locke solution or Locke containing the appropriate inhibitors. For some experiments, media derived from mast cells stimulated by compound 48/80 were used as a source of mast cell CPA activity. Treatment of mast cells with the highly specific peptide inhibitor of CPA derived from potato (PCI) inhibited histamine release in response to NT and NT8-13 (the biologically active region of NT). This inhibition required some 20 min to develop and was only partially reversed by a 20-min wash period. PCI (10 microM) did not inhibit histamine release in response to NT1-12, bradykinin, compound 48/80, the calcium ionophore, A23187, or anti-IgE serum. PCI also inhibited mast cell CPA activity. SR 48692, a highly selective antagonist of the brain NT receptor and of NT-stimulated mast cell secretion, also inhibited mast cell CPA activity as well as bovine pancreatic CPA activity in a concentration-dependent manner. It is suggested that the mast cell binding site for NT and the active site for CPA may share similar characteristics. The results are discussed in terms of NT mechanism of action on the mast cell.

¿Argumentar para definir o definir para argumentar?

OpenAIRE

Silva, Luz; Samper, Carmen

2013-01-01

Se presenta y se ilustra un marco de referencia de un estudio en curso para obtener el título de Maestría en Docencia de la Matemática de la Universidad Pedagógica Nacional (Colombia); estudio sobre la conexión entre las acciones de definir y argumentar, que puede contribuir a la práctica de profesores en ejercicio y en formación. La habilidad para construir una definición es un posible indicio de comprensión, mientras que saberla de memoria no garantiza la comprensión del concepto (Vinner, 1...

Guias ópticos para sensores

OpenAIRE

Marcos de Castro Pacitti

1993-01-01

Neste trabalho foram estudados guias ópticos para atuarem como sensores ou em sistemas sensores. Ênfase especial foi dada em guias ópticos retangulares, para dispositivos ópticos integrados, e fibras ópticas elípticas. A analise de fibras ópticas elípticas resultou em um modelamento pratico para projeto das mesmas em aplicações onde se deseja operar com dois modos guiados, situação esta que se mostra muito atraente para implementação de diversos tipos de sensores a fibra óptica. A seguir es...

Labbtex: Toolbox para generación de informes en LATEX para Matlab

Directory of Open Access Journals (Sweden)

José Luis Almazán Gárate

2012-10-01

Full Text Available En este artículo se presenta el software desarrollado por el Equipo H3lite dentro del Departamento de Ingeneniería Civil. Transportes de la Escuela de Ingenieros de Caminos, Canales y Puertos de la Universidad Politécnica de Madrid para la generación de informes enLATEX mediante el software Matlab® y la integración en sus rutinas, Labbtex.La librería Labbtex proporciona un marco flexible para mezclar texto y código Matlab® para la generación automática de documentos. Un rchivo fuente simple contiene el texto de documentación y el código Matlab, al correr la aplicación se genera un documento final LATEX que contiene el texto, gráficos y tablas indicados con el formato de un documento LATEX. El código Matlab genera un documento LATEX usando la sintaxis. Así, LATEX (para composición de texto de alta calidad y Matlab® (para cálculo matemático pueden usarse simultáneamente. Esto permite la generación de informes en tiempo real con un uso de recursos mínimo.

Low-energy electron dose-point kernel simulations using new physics models implemented in Geant4-DNA

Energy Technology Data Exchange (ETDEWEB)

Bordes, Julien, E-mail: julien.bordes@inserm.fr [CRCT, UMR 1037 INSERM, Université Paul Sabatier, F-31037 Toulouse (France); UMR 1037, CRCT, Université Toulouse III-Paul Sabatier, F-31037 (France); Incerti, Sébastien, E-mail: incerti@cenbg.in2p3.fr [Université de Bordeaux, CENBG, UMR 5797, F-33170 Gradignan (France); CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan (France); Lampe, Nathanael, E-mail: nathanael.lampe@gmail.com [Université de Bordeaux, CENBG, UMR 5797, F-33170 Gradignan (France); CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan (France); Bardiès, Manuel, E-mail: manuel.bardies@inserm.fr [CRCT, UMR 1037 INSERM, Université Paul Sabatier, F-31037 Toulouse (France); UMR 1037, CRCT, Université Toulouse III-Paul Sabatier, F-31037 (France); Bordage, Marie-Claude, E-mail: marie-claude.bordage@inserm.fr [CRCT, UMR 1037 INSERM, Université Paul Sabatier, F-31037 Toulouse (France); UMR 1037, CRCT, Université Toulouse III-Paul Sabatier, F-31037 (France)

2017-05-01

When low-energy electrons, such as Auger electrons, interact with liquid water, they induce highly localized ionizing energy depositions over ranges comparable to cell diameters. Monte Carlo track structure (MCTS) codes are suitable tools for performing dosimetry at this level. One of the main MCTS codes, Geant4-DNA, is equipped with only two sets of cross section models for low-energy electron interactions in liquid water (“option 2” and its improved version, “option 4”). To provide Geant4-DNA users with new alternative physics models, a set of cross sections, extracted from CPA100 MCTS code, have been added to Geant4-DNA. This new version is hereafter referred to as “Geant4-DNA-CPA100”. In this study, “Geant4-DNA-CPA100” was used to calculate low-energy electron dose-point kernels (DPKs) between 1 keV and 200 keV. Such kernels represent the radial energy deposited by an isotropic point source, a parameter that is useful for dosimetry calculations in nuclear medicine. In order to assess the influence of different physics models on DPK calculations, DPKs were calculated using the existing Geant4-DNA models (“option 2” and “option 4”), newly integrated CPA100 models, and the PENELOPE Monte Carlo code used in step-by-step mode for monoenergetic electrons. Additionally, a comparison was performed of two sets of DPKs that were simulated with “Geant4-DNA-CPA100” – the first set using Geant4′s default settings, and the second using CPA100′s original code default settings. A maximum difference of 9.4% was found between the Geant4-DNA-CPA100 and PENELOPE DPKs. Between the two Geant4-DNA existing models, slight differences, between 1 keV and 10 keV were observed. It was highlighted that the DPKs simulated with the two Geant4-DNA’s existing models were always broader than those generated with “Geant4-DNA-CPA100”. The discrepancies observed between the DPKs generated using Geant4-DNA’s existing models and “Geant4-DNA-CPA100” were

An investigation into the application of customer profitability analysis as a strategic decision-making tool in a hospitality environment

OpenAIRE

Noone, Breffni M

1997-01-01

The primary objective of this study was to investigate the Applicability of Customer Profitability Analysis as a strategic decision-making technique in a hospitality environment. The study commenced with a review of literature in the fields of Yield Management, Customer Profitability Analysis (CPA) and Activity-Based Costing (ABC), with ABC being identified as an appropriate method of costing to use in CPA. Issues arising from the implementation of an Activity-Based CPA including the purpose ...

Intermittent Metronomic Drug Schedule Is Essential for Activating Antitumor Innate Immunity and Tumor Xenograft Regression

Directory of Open Access Journals (Sweden)

Chong-Sheng Chen

2014-01-01

Full Text Available Metronomic chemotherapy using cyclophosphamide (CPA is widely associated with antiangiogenesis; however, recent studies implicate other immune-based mechanisms, including antitumor innate immunity, which can induce major tumor regression in implanted brain tumor models. This study demonstrates the critical importance of drug schedule: CPA induced a potent antitumor innate immune response and tumor regression when administered intermittently on a 6-day repeating metronomic schedule but not with the same total exposure to activated CPA administered on an every 3-day schedule or using a daily oral regimen that serves as the basis for many clinical trials of metronomic chemotherapy. Notably, the more frequent metronomic CPA schedules abrogated the antitumor innate immune and therapeutic responses. Further, the innate immune response and antitumor activity both displayed an unusually steep dose-response curve and were not accompanied by antiangiogenesis. The strong recruitment of innate immune cells by the 6-day repeating CPA schedule was not sustained, and tumor regression was abolished, by a moderate (25% reduction in CPA dose. Moreover, an ~20% increase in CPA dose eliminated the partial tumor regression and weak innate immune cell recruitment seen in a subset of the every 6-day treated tumors. Thus, metronomic drug treatment must be at a sufficiently high dose but also sufficiently well spaced in time to induce strong sustained antitumor immune cell recruitment. Many current clinical metronomic chemotherapeutic protocols employ oral daily low-dose schedules that do not meet these requirements, suggesting that they may benefit from optimization designed to maximize antitumor immune responses.

Internet como instrumento para la Yihad

Directory of Open Access Journals (Sweden)

Alfonso Merlos García

2006-01-01

Full Text Available Las extraordinarias ventajas que ofrece Internet lo han convertido en un instrumento clave y dinámico en la estrategia de los yihadistas. Los medios de comunicación, la clase política y las agencias de seguridad e información han tendido a concentrar sus esfuerzos en la neutralización del ciberterrorismo sin prestar suficiente atención a los múltiples usos de Internet que están haciendo los neosalafistas: para la propaganda y para la guerra psicológica, para el reclutamiento y para la financiación, para la documentación y para la planificación de atentados. Las democracias deberían considerar el coste que tendrá la derrota frente al movimiento yihadista globalizado en la batalla por el ciberespacio

Cost and performance analysis of physical protection systems - a case study

International Nuclear Information System (INIS)

Hicks, M.J.; Snell, M.S.; Sandoval, J.S.; Potter, C.S.

1998-01-01

Design and analysis of physical protection systems requires (1) identification of mission critical assets; (2) identification of potential threats that might undermine mission capability; (3) identification of the consequences of loss of mission-critical assets (e.g., time and cost to recover required capability and impact on operational readiness); and (4) analysis of the effectiveness of physical protection elements. CPA -- Cost and Performance Analysis -- addresses the fourth of these four issues. CPA is a methodology that joins Activity Based Cost estimation with performance-based analysis of physical protection systems. CPA offers system managers an approach that supports both tactical decision making and strategic planning. Current exploratory applications of the CPA methodology address analysis of alternative conceptual designs. Hypothetical data is used to illustrate this process

Tunable fractional-order capacitor using layered ferroelectric polymers

KAUST Repository

Agambayev, Agamyrat

2017-09-05

Pairs of various Polyvinylidene fluoride P(VDF)-based polymers are used for fabricating bilayer fractional order capacitors (FOCs). The polymer layers are constructed using a simple drop casting approach. The resulting FOC has two advantages: It can be easily integrated with printed circuit boards, and its constant phase angle (CPA) can be tuned by changing the thickness ratio of the layers. Indeed, our experiments show that the CPA of the fabricated FOCs can be tuned within the range from -83° to -65° in the frequency band changing from 150 kHz to 10 MHz. Additionally, we provide an empirical formula describing the relationship between the thickness ratio and the CPA, which is highly useful for designing FOCs with the desired CPA.

THE INFLUENCE OF THE CONSUMER PROTECTION ACT 68 OF 2008 ON THE COMMON LAW WARRANTY AGAINST EVICTION: A COMPARATIVE OVERVIEW

Directory of Open Access Journals (Sweden)

J Barnard

2012-12-01

Full Text Available The implementation of the Consumer Protection Act 68 of 2008 (CPA has great implications for the South African common law of sale. In this contribution the influence of the CPA on the seller’s common law duty to warrant the buyer against eviction is investigated. Upon evaluation of the relevant provisions of the CPA, the legal position in the United Kingdom – specifically the provisions of the Sales of Goods Act of 1979 – is investigated.

Cross-elicitation responses to 2-methoxymethyl-para-phenylenediamine in para-phenylenediamine-allergic individuals

NARCIS (Netherlands)

Schuttelaar, M.-L.; Coenraads, P.-J.; Blömeke, B.; Goebel, C.

2016-01-01

The introduction of a methoxymethyl side chain into para-phenylenediamine (PPD) resulted in the development of a new hair dye molecule: 2-methoxymethyl-para-phenylenediamine (Me-PPD). Besides having excellent hair colouring properties, this PPD derivate has significantly lower skin-sensitizing

Oro para Colombia

OpenAIRE

Rubio Forero, María Claudia

2016-01-01

Las mujeres han debido atravesar un largo camino partiendo de la discriminación hasta empezar un proceso de equidad en la sociedad y en el deporte, de esta manera llegar a ser parte de un evento como los Juegos Olímpicos. Esta tesis toma el caso de tres atletas colombianas y describe su proceso de formación para lograr dos medallas de oro para el país.

Analytical applications of condensed phosphoric acid-I Determination of ferrous and total iron in iron ores after decomposition with condensed phosphoric acid.

Science.gov (United States)

Mizoguchi, T; Ishii, H

1978-06-01

A simple method is described for the determination of ferrous and total iron in iron ores. Iron ores are dissolved by condensed phosphoric acid (CPA) very rapidly without any tedious and time-consuming manipulations such as elimination of silica and filtration. Under the proposed conditions (amount of sample 100 mg, amount of CPA added 10 g, heating temperature 290 degrees , heating time 30 min), magnetite, limonite and hematite are completely dissolved. The iron content can be determined in the presence of condensed phosphoric acid by titration with dichromate solution, if a slight modification is made. The total iron in iron ores, determined by the present method, is in agreement with that found by the JIS method. The ferrous iron in iron ores can be determined by dissolving the samples with CPA in a nitrogen atmosphere and titrating with dichromate solution. Chelatometric titration of iron after solvent extraction with MIBK from solutions prepared by use of CPA is found to be accurate for samples such as pyrite cinder. The ability of CPA to dissolve various materials has been investigated.

Systematic examination of publicly-available information reveals the diverse and extensive corporate political activity of the food industry in Australia.

Science.gov (United States)

Mialon, Melissa; Swinburn, Boyd; Allender, Steven; Sacks, Gary

2016-03-22

The political influence of the food industry, referred to as corporate political activity (CPA), represents a potential barrier to the development and implementation of effective public health policies for non-communicable diseases prevention. This paper reports on the feasibility and limitations of using publicly-available information to identify and monitor the CPA of the food industry in Australia. A systematic search was conducted for information from food industry, government and other publicly-available data sources in Australia. Data was collected in relation to five key food industry actors: the Australian Food and Grocery Council; Coca Cola; McDonald's; Nestle; and Woolworths, for the period January 2012 to February 2015. Data analysis was guided by an existing framework for classifying CPA strategies of the food industry. The selected food industry actors used multiple CPA strategies, with 'information and messaging' and 'constituency building' strategies most prominent. The systematic analysis of publicly-available information over a limited period was able to identify diverse and extensive CPA strategies of the food industry in Australia. This approach can contribute to accountability mechanisms for NCD prevention.

The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists

Directory of Open Access Journals (Sweden)

Tamotsu Tsukahara

2012-01-01

Full Text Available In recent years, peroxisome proliferator-activated receptor gamma (PPARγ has been reported to be a target for the treatment of type II diabetes. Furthermore, it has received attention for its therapeutic potential in many other human diseases, including atherosclerosis, obesity, and cancers. Recent studies have provided evidence that the endogenously produced PPARγ antagonist, 2,3-cyclic phosphatidic acid (cPA, which is similar in structure to lysophosphatidic acid (LPA, inhibits cancer cell invasion and metastasis in vitro and in vivo. We recently observed that cPA negatively regulates PPARγ function by stabilizing the binding of the corepressor protein, silencing mediator of retinoic acid and thyroid hormone receptor. We also showed that cPA prevents neointima formation, adipocyte differentiation, lipid accumulation, and upregulation of PPARγ target gene transcription. We then analyzed the molecular mechanism of cPA's action on PPARγ. In this paper, we summarize the current knowledge on the mechanism of PPARγ-mediated transcriptional activity and transcriptional repression in response to novel lipid-derived ligands, such as cPA.

Interferometric Control of Dual-Band Terahertz Perfect Absorption Using a Designed Metasurface

Science.gov (United States)

Kang, Ming; Zhang, Huifang; Zhang, Xueqian; Yang, Quanlong; Zhang, Weili; Han, Jiaguang

2018-05-01

The coherent perfect absorber (CPA), a time-reversed counterpart to the laser emission, could cause all energy fed to the system to be absorbed. It can also be used as an absorptive interferometer, which could provide applications in controllable optical energy transfer. Here, in order to achieve a terahertz CPA, we propose a designed metasurface and experimentally demonstrate that it can serve as a polarization-insensitive CPA at a one-frequency channel under normal symmetric excitation, while a transverse-electric CPA at two-frequency channels around oblique 40° symmetric incidence. Such phenomena in this system can be attributed to Fano resonance consisting of interacting one bright and one dark mode under normal incidence and an additional operative dark mode under oblique symmetric excitation. The experimental results find good agreement with the fitted coupled-mode theory. Moreover, we show that the output amplitude can be effectively tuned from 0 to 1 only by varying the relative phase between the two input waves. The designed CPA could find potential application in effectively controlling absorption for terahertz imaging and terahertz switches.

Infraestructura para laboratorios de acceso remoto

Directory of Open Access Journals (Sweden)

López Luro, Francisco

2009-01-01

Full Text Available Las tecnologías de Internet permiten el uso de sistemas de software distribuido para el acceso en forma remota a laboratorios físicos y virtuales, para llevar a cabo actividades de investigación experimental a distancia. A partir de los marcos teóricos que definen los estructurantes de los laboratorios, los implementadores de laboratorios de acceso remoto deben diseñar y desarrollar arquitecturas de servicios que permitan un acceso flexible y controlado. Este trabajo define una infraestructura para la implementación de aplicaciones para el acceso remoto a laboratorios físicos y virtuales y para la gestión de los mismos. Se presentan conceptos que permiten extender la modalidad tradicional de conexión con un dispositivo, para llevar adelante actividades prácticas de laboratorio colaborativas y concurrentes.

Development and validation of a high-performance liquid chromatographic method for the determination of cyproterone acetate in human skin.

Science.gov (United States)

Henry de Hassonville, Sandrine; Chiap, Patrice; Liégeois, Jean-François; Evrard, Brigitte; Delattre, Luc; Crommen, Jacques; Piel, Géraldine; Hubert, Philippe

2004-09-21

In the framework of a preliminary study on the transdermal penetration of cyproterone acetate (CPA), a simple and rapid procedure involving an extraction step coupled to a HPLC-UV determination has been developed for the separation and quantification of CPA in the two main skin layers-epidermis and dermis-after local application. The separation of epidermis and dermis layers was carefully carried out by means of a sharp spatula after skin immersion in heated water at 65 degrees C. The two skin layers were then treated separately according to the same process: (1) sample homogenization by vibration after freezing with liquid nitrogen in a Mikro-Dismembrator; (2) CPA extraction with methanol after addition of the internal standard (betamethasone dipropionate); (3) centrifugation; (4) evaporation of a supernatant aliquot; (5) dissolution of the dry residue in methanol and addition of water; (6) centrifugation; (7) injection of a supernatant aliquot into the HPLC system. The separation was achieved on octadecylsilica stationary phase using a mobile phase consisting in a mixture of acetonitrile and water (40:60 (v/v)). The method was then validated using a new approach based on accuracy profiles over a CPA concentration range from 33 to 667 ng/ml for each skin layer. Finally, the method was successfully applied to the determination of CPA to several skin samples after topical application of different gel formulations containing CPA.

Metabolic borderzone in acutely ischemic canine myocardium demonstrated by positron-CT (PCT)

International Nuclear Information System (INIS)

Schwaiger, M.; Hansen, H.; Selin, C.; Wittmer, S.; Barrio, J.; Schelbert, H.R.

1984-01-01

Acute coronary ligation in dogs results in an area of myocardial dysfunction that exceeds the area of subsequent necrosis suggesting the existence of an ischemic ''borderzone'' of reversibly injured myocardium. The authors tested this hypothesis in 9 closed chest dogs with C-11 plamitate (CPA) and serial PCT imaging after an LAD occlusion. Using a blood flow (MBF) image obtained with iv N-13 ammonia prior to CPA, regions of interest were assigned on the serial CPA cross-sectional images to the center (IC) and border (IB) of the ischemic segment and to control myocardium (CO). CPA uptake was closely related to MBF (r=0.88) implicating flow as a major determinant of CPA uptake. Clearance helftimes (T 1/2) and relative sizes (RS) of the early rapid phase on the C-11 tissue time activity curves were determined for IC, IB and CO. In IC, MBF, RS and T 1/2 were markedly depressed indicating impaired CPA utilization and oxidation. In IB, MBF was less than in CO though only insignificantly, while RS and T 1/2 were highly abnormal. The authors conclude that FFA metabolism in areas adjacent to ischemic segments but without significant MBF decreases in abnormal, presenting evidence for a metabolic borderzone which now can be identified noninvasively with positron emission tomography

Attenuation of the cyproterone acetate-induced testicular hypofunction by a novel nutraceutical lycopene: a genomic approach.

Science.gov (United States)

Tripathy, A; Ghosh, A; Dey, A; Pakhira, B P; Ghosh, D

2017-10-01

This study was designed to explore the cyproterone acetate (CPA)-induced andrological hypofunction and its correction by oral administration of lycopene. In this concern, spermatogenic, biochemical, histological and genomic profiles were studied. Cyproterone acetate administration for 1 month helped to develop infertile model rats. A significant recovery was noted in sperm motility, sperm count, sperm viability, hypo-osmotic swelling tail-coiled spermatozoa; activities of testicular ∆ 5 , 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, catalase (CAT) and superoxide dismutase (SOD); and levels of conjugated diene (CD), malondialdehyde (MDA), testicular cholesterol and serum testosterone after the administration of lycopene at 1.5 mg/0.5 ml Tween-80/100 g body weight/day for last 1 month to infertile model rats. Simultaneously, qRT-PCR study of Bax, Bcl-2, caspase-3, ∆ 5 , 3β-HSD and 17β-HSD genes in testicular tissue showed a significant rectification towards the control in CPA-pre-treated cum CPA-lycopene-cotreated rats. Side-by-side histological and histometric studies showed a significant correction in qualitative analysis of spermatogenesis and seminiferous tubular diameter (STD) in CPA-pre-treated cum CPA-lycopene-cotreated rats. Lycopene showed outstanding efficacy in the management of CPA-induced testicular hypofunction with special reference to correction in oxidative stress-induced testicular apoptosis at genomic level. © 2016 Blackwell Verlag GmbH.

Green function theory of random ferromagnets with large exchange anisotropy

International Nuclear Information System (INIS)

Patterson, J.D.

1977-01-01

Spin 1/2 systems which are coupled with an Ising-like Hamiltonian with fluctuating exchange are discussed by the use of thermodynamic Green functions in four different approximations. The first is equivalent to a local mean field approximation and the second is an approximation to the first in which the local mean field is assumed to be proportional to the overall magnetization and to the sum of the neighboring exchange 'bonds'. The third is also a special case of the first, but the local mean field is approximated in such a way as to be appropriate for the discussion of spin glasses. The fourth is a coherent potential-like approximation (CPA). The second approximation can be shown to imply no reduction of the Curie temperature (T sub(c)) due to exchange fluctuations, while the CPA does result in a lowering of T sub(c) (assuming small fluctuations about an average positive exchange in both cases). However, the CPA that was used is also an approximation to the second method. Hence, even though the CPA does result in a lowering of T sub(c) (which is generally conceded to be correct for the original model), this fact cannot be used as an argument for the validity of the CPA. This calculation thus emphasizes the necessity of critically examining any CPA-like calculation before accepting its predictions as valid [pt

Role of Adult Attachment in the Intergenerational Transmission of Violence: Mediator, Moderator, or Independent Predictor?

National Research Council Canada - National Science Library

Merrill, Lex L; Thomsen, Cynthia J; Crouch, Julie L; May, Patricia; Gold, Steven R; Milner, Joel S

2002-01-01

...], child sexual abuse [CSA], domestic violence [DV]) on adult CPA risk and examined whether adult attachment serves as a mediator or moderator of these relationships, or as an independent predictor of CPA risk...

Characterization of the differences in the cyclopiazonic acid binding mode to mammalian and P. Falciparum Ca2+ pumps: a computational study.

KAUST Repository

Di Marino, Daniele

2015-03-01

Despite the investments in malaria research, an effective vaccine has not yet been developed and the causative parasites are becoming increasingly resistant to most of the available drugs. PfATP6, the sarco/endoplasmic reticulum Ca2+ pump (SERCA) of P. falciparum, has been recently genetically validated as a potential antimalarial target and cyclopiazonic acid (CPA) has been found to be a potent inhibitor of SERCAs in several organisms, including P. falciparum. In position 263, PfATP6 displays a leucine residue, whilst the corresponding position in the mammalian SERCA is occupied by a glutamic acid. The PfATP6 L263E mutation has been studied in relation to the artemisinin inhibitory effect on P. falciparum and recent studies have provided evidence that the parasite with this mutation is more susceptible to CPA. Here, we characterized, for the first time, the interaction of CPA with PfATP6 and its mammalian counterpart to understand similarities and differences in the mode of binding of the inhibitor to the two Ca2+ pumps. We found that, even though CPA does not directly interact with the residue in position 263, the presence of a hydrophobic residue in this position in PfATP6 rather than a negatively charged one, as in the mammalian SERCA, entails a conformational arrangement of the binding pocket which, in turn, determines a relaxation of CPA leading to a different binding mode of the compound. Our findings highlight differences between the plasmodial and human SERCA CPA-binding pockets that may be exploited to design CPA derivatives more selective toward PfATP6.

Characterization of the differences in the cyclopiazonic acid binding mode to mammalian and P. Falciparum Ca2+ pumps: a computational study.

KAUST Repository

Di Marino, Daniele; D'Annessa, Ilda; Coletta, Andrea; Via, Allegra; Tramontano, Anna

2015-01-01

Despite the investments in malaria research, an effective vaccine has not yet been developed and the causative parasites are becoming increasingly resistant to most of the available drugs. PfATP6, the sarco/endoplasmic reticulum Ca2+ pump (SERCA) of P. falciparum, has been recently genetically validated as a potential antimalarial target and cyclopiazonic acid (CPA) has been found to be a potent inhibitor of SERCAs in several organisms, including P. falciparum. In position 263, PfATP6 displays a leucine residue, whilst the corresponding position in the mammalian SERCA is occupied by a glutamic acid. The PfATP6 L263E mutation has been studied in relation to the artemisinin inhibitory effect on P. falciparum and recent studies have provided evidence that the parasite with this mutation is more susceptible to CPA. Here, we characterized, for the first time, the interaction of CPA with PfATP6 and its mammalian counterpart to understand similarities and differences in the mode of binding of the inhibitor to the two Ca2+ pumps. We found that, even though CPA does not directly interact with the residue in position 263, the presence of a hydrophobic residue in this position in PfATP6 rather than a negatively charged one, as in the mammalian SERCA, entails a conformational arrangement of the binding pocket which, in turn, determines a relaxation of CPA leading to a different binding mode of the compound. Our findings highlight differences between the plasmodial and human SERCA CPA-binding pockets that may be exploited to design CPA derivatives more selective toward PfATP6.

THREE DECADES OF CONSUMER PROTECTION OF RIGHTS ACT: RURAL INDIA NEEDS FOCUSED ATTENTION

OpenAIRE

Dr. Amrit Patel

2017-01-01

India has been observing December 24 each year since 1986 as “National Consumer Rights Day”, when the Consumer Protection Act [CPA], 1986 came into force on this day. Despite the implementation of the CPA has completed three decades in the country, the rural India has yet to understand the meaning of consumer’s rights & the procedure to protect the right enshrined in the CPA,1986. This has its significance because according to the National Council of Applied Economic Research survey report th...

Diseño de imágenes para ciegos, material didáctico para niños con discapacidad visual.

OpenAIRE

FUENTES NIEVES, FABIOLA MIREYA

2014-01-01

El objetivo de este proyecto es contribuir investigación para la creación, la aplicación, la transformación del quehacer profesional del diseño gráfico en el conocimiento y las habilidades, en la formación de profesionales en el área del diseño para material didáctico para esta disciplina, por lo cual es necesario cambiar respuestas para lo local y/o para la globalización. En la historia del diseño, se plantea, proyectar para la globalización, para la humanidad. Ahora el planteamiento de r...

Next generation Chirped Pulse Amplification

Energy Technology Data Exchange (ETDEWEB)

Nees, J; Biswal, S; Mourou, G [Univ. Michigan, Center for Ultrafast Optical Science, Ann Arbor, MI (United States); Nishimura, Akihiko; Takuma, Hiroshi

1998-03-01

The limiting factors of Chirped Pulse Amplification (CPA) are discussed and experimental results of CPA in Yb:glass regenerative amplifier are given. Scaling of Yb:glass to the petawatt level is briefly discussed. (author)

Synthesis and characterization of acrylate copolymer containing fluorescein functional group

International Nuclear Information System (INIS)

Hui, Guodong; Huang, Weiyun; Song, Yunzhao; Chen, Deben; Zhong, Anyong

2013-01-01

We report a novel method to fabricate fluorescent polymer (F-CPA) based on the esterification between acrylate copolymer (CPA) and fluorescein using N, N-dicyclohexylcarbodiimide (DCC)/4-dimethylaminopyridine (DMAP) as catalyst. The resulting copolymer was characterized by Fourier transform-infrared spectroscopy (FT-IR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), ultraviolet-visible spectroscopy (UV-Vis) and fluorescence spectroscopy. In addition, the influences of concentration, solvents, pH and metal cations (Cu"2"+, Fe"3"+ and Zn"2"+) on the fluorescent behaviors of F-CPA are discussed in detail. All those observations suggest that the synthesized F-CPA is an excellent luminescent macromolecular material with simple synthesis method and excellent solubility. Moreover, its sensitive fluorescence response behaviors to solvents, pH and metal cations make it to become a polymer-based probe

The para-petroleum industry

International Nuclear Information System (INIS)

2002-07-01

The para-petroleum industry includes societies that realize studies and installations for the deposits exploitation. This document presents the situation of the para-petroleum industry in 2001, the world investment growth of the activity, the french societies financial results and an inventory of the main operations in the amalgamation domain. (A.L.B.)

Adesao ao guia alimentar para populacao brasileira

Directory of Open Access Journals (Sweden)

Eliseu Verly Junior

2013-12-01

Full Text Available OBJETIVO : Analisar a adesão ao Guia Alimentar para População Brasileira. MÉTODOS : Amostra composta por participantes do Inquérito de Saúde de São Paulo (n = 1.661 que preencheram dois recordatórios de 24 horas. Foi utilizado modelo bivariado de efeito misto para a razão entre o consumo de energia do grupo de alimentos e o consumo calórico total. A razão estimada foi utilizada para calcular o percentual de indivíduos com consumo abaixo ou acima da recomendação. RESULTADOS : Pelo menos 80,0% da população consome abaixo do recomendado para: leite e derivados; frutas e sucos de frutas; e cereais, tubérculos e raízes; aproximadamente 60,0% para legumes e verduras; 30,0% para feijões; e 8,0% para carnes e ovos. Adolescentes apresentaram a maior inadequação para legumes e verduras (90,0%, e o estrato de maior renda foi associado à menor inadequação para óleos, gorduras e sementes oleaginosas (57,0%. CONCLUSÕES : Foi observado consumo inadequado dos grupos de alimentos relacionados com aumento do risco de doenças crônicas.

Nonvestibular schwannoma tumors in the cerebellopontine angle: A structured approach and management guidelines

DEFF Research Database (Denmark)

Springborg, J.B.; Poulsgaard, L.; Thomsen, Jens Christian

2008-01-01

The most common cerebellopontine angle (CPA) tumor is a vestibular schwannoma, but one in five CPA tumors are not vestibular schwannomas. These tumors may require different management strategies. Compared with vestibular schwannomas, symptoms and signs from cranial nerve VIII are less frequent......: other cranial nerve and cerebellar symptoms and signs predominate in patients with these less common CPA tumors. Computed tomography and magnetic resonance imaging often show features leading to the correct diagnosis. Treatment most often includes surgery, but a policy of observation or subtotal...

Comprehensive protein profiling by multiplexed capillary zone electrophoresis using cross-linked polyacrylamide coated capillaries.

Science.gov (United States)

Liu, Shaorong; Gao, Lin; Pu, Qiaosheng; Lu, Joann J; Wang, Xingjia

2006-02-01

We have recently developed a new process to create cross-linked polyacrylamide (CPA) coatings on capillary walls to suppress protein-wall interactions. Here, we demonstrate CPA-coated capillaries for high-efficiency (>2 x 10(6) plates per meter) protein separations by capillary zone electrophoresis (CZE). Because CPA virtually eliminates electroosmotic flow, positive and negative proteins cannot be analyzed in a single run. A "one-sample-two-separation" approach is developed to achieve a comprehensive protein analysis. High throughput is achieved through a multiplexed CZE system.

Algoritmos para problemas de empacotamento

OpenAIRE

Eduardo Candido Xavier

2006-01-01

Resumo: Neste trabalho estudamos diversos problemas de empacotamento considerados NP-difíceis. Assumindo a hipótese de que P ? NP, sabemos que não existem algoritmos eficientes (complexidade de tempo polinomial) exatos para resolver tais problemas. Uma das abordagens consideradas para tratar tais problemas é a de algoritmos de aproximação, que são algoritmos eficientes e que geram soluções com garantia de qualidade. Neste trabalho apresentamos alguns algoritmos aproximados para problemas de e...

Relação entre as palavras eliciadas na Avaliação Fonológica da Criança e as variáveis idade, gênero e gravidade do desvio fonológico Relationship between words elicited in the Children Phonological Assessment and the variables age, gender and severity level of the phonological disorders

Directory of Open Access Journals (Sweden)

Angélica Savoldi

2012-01-01

Full Text Available OBJETIVO: Verificar a relação entre as palavras pertencentes e não pertencentes à Avaliação Fonológica da Criança (AFC e as variáveis idade, gênero e gravidade do desvio fonológico (DF, e analisar as palavras produzidas e as palavras substituídas com maior frequência na AFC. MÉTODOS: Fizeram parte do estudo 45 crianças com DF, de ambos os gêneros, com idades entre 4 anos e 7 anos e 11 meses. O corpus de fala foi composto por 6463 palavras, que foram divididas em palavras pertencentes ou não à AFC. A amostra foi dividida quanto à faixa etária, à gravidade do desvio fonológico e ao gênero. Os dados foram analisados estatisticamente. RESULTADOS: Houve maior produção de palavras não pertencentes à AFC e relação significativa entre a palavra pertencer ou não ao AFC quanto à faixa etária, gênero e gravidade do DF. As palavras-alvo enunciadas com maior frequência foram equivalentes a nomes de objetos do dia a dia da criança, ao contrário das substituições, que foram mais frequentes quando a palavra-alvo correspondia a objetos não conhecidos visualmente pelas crianças. CONCLUSÃO: A produção de palavras pertencentes à AFC é influenciada pela idade, gênero e gravidade do DF. É fundamental que nas palavras selecionadas para uma avaliação fonológica sejam consideradas tais variáveis, bem como, aspectos regionais, classe gramatical de substantivo, e o repertório da criança.PURPOSE: To verify the relationship between words belonging and not belonging to the Children Phonological Assessment (CPA and the variables age, gender, and severity level of phonological disorders (PD, and to analyze the most frequently produced and substituted words in the CPA. METHODS: Participants were 45 children with PD of both genders, aged between 4 years and 7 years and 11 months. The speech corpus was composed of 6463 words, divided into belonging and not belonging in the CPA. The sample was divided according to age, gender

Effects of antiandrogenic progestins, chlormadinone and cyproterone acetate, and the estrogen 17α-ethinylestradiol (EE2), and their mixtures: Transactivation with human and rainbowfish hormone receptors and transcriptional effects in zebrafish (Danio rerio) eleuthero-embryos

Energy Technology Data Exchange (ETDEWEB)

Siegenthaler, Patricia Franziska [University of Applied Sciences and Arts Northwestern Switzerland (FHNW), School of Life Sciences, Gründenstrasse 40, CH-4132 Muttenz (Switzerland); Bain, Peter [Commonwealth Scientific and Industrial Research Organisation (CSIRO), Land and Water Flagship, PMB2, Glen Osmond, 5064 South Australia (Australia); Riva, Francesco [IRCCS – Istituto di Ricerche Farmacologiche “Mario Negri”, Environmental Biomarkers Unit, Department of Environmental Health Sciences, Via La Masa 19, I-20156 Milan (Italy); Fent, Karl, E-mail: karl.fent@fhnw.ch [University of Applied Sciences and Arts Northwestern Switzerland (FHNW), School of Life Sciences, Gründenstrasse 40, CH-4132 Muttenz (Switzerland); Swiss Federal Institute of Technology (ETH Zürich), Institute of Biogeochemistry and Pollution Dynamics, Department of Environmental System Sciences, CH-8092 Zürich (Switzerland)

2017-01-15

Highlights: • Agonistic and antagonistic activity of CMA and CPA were assessed in vitro. • CMA and CPA showed different interaction with human and fish receptors. • No progestogenic but antiandrogenic and antiglucocorticoid activity occurred in fish. • CMA and CPA showed transcriptional changes in zebrafish embryos. • Binary mixtures of the progestins with EE2 were assessed in vitro and in vivo. - Abstract: Synthetic progestins act as endocrine disrupters in fish but their risk to the environment is not sufficiently known. Here, we focused on an unexplored antiandrogenic progestin, chlormadinone acetate (CMA), and the antiandrogenic progestin cyproterone acetate (CPA). The aim was to evaluate whether their in vitro interaction with human and rainbowfish (Melanotaenia fluviatilis) sex hormone receptors is similar. Furthermore, we investigated their activity in zebrafish (Danio rerio) eleuthero-embryos. First, we studied agonistic and antagonistic activities of CMA, CPA, and 17α-ethinylestradiol (EE2), in recombinant yeast expressing either the human progesterone (PGR), androgen (AR), or estrogen receptor. The same compounds were also investigated in vitro in a stable transfection cell system expressing rainbowfish nuclear steroid receptors. For human receptors, both progestins exhibited progestogenic, androgenic and antiestrogenic activity with no antiandrogenic or estrogenic activity. In contrast, interactions with rainbowfish receptors showed no progestogenic, but antiandrogenic, antiglucocorticoid, and some antiestrogenic activity. Thus, interaction with and transactivation of human and rainbowfish PGR and AR were distinctly different. Second, we analyzed transcriptional alterations in zebrafish eleuthero‐embryos at 96 and 144 h post fertilization after exposure to CPA, CMA, EE2, and binary mixtures of CMA and CPA with EE2, mimicking the use in oral contraceptives. CMA led to slight down-regulation of the ar transcript, while CPA down-regulated ar

Towards a Collaborative Research: A Case Study on Linking Science to Farmers’ Perceptions and Knowledge on Arabica Coffee Pests and Diseases and Its Management

Science.gov (United States)

Liebig, Theresa; Läderach, Peter; Poehling, Hans-Michael; Kucel, Patrick; Van Asten, Piet; Avelino, Jacques

2016-01-01

The scientific community has recognized the importance of integrating farmer’s perceptions and knowledge (FPK) for the development of sustainable pest and disease management strategies. However, the knowledge gap between indigenous and scientific knowledge still contributes to misidentification of plant health constraints and poor adoption of management solutions. This is particularly the case in the context of smallholder farming in developing countries. In this paper, we present a case study on coffee production in Uganda, a sector depending mostly on smallholder farming facing a simultaneous and increasing number of socio-ecological pressures. The objectives of this study were (i) to examine and relate FPK on Arabica Coffee Pests and Diseases (CPaD) to altitude and the vegetation structure of the production systems; (ii) to contrast results with perceptions from experts and (iii) to compare results with field observations, in order to identify constraints for improving the information flow between scientists and farmers. Data were acquired by means of interviews and workshops. One hundred and fifty farmer households managing coffee either at sun exposure, under shade trees or inter-cropped with bananas and spread across an altitudinal gradient were selected. Field sampling of the two most important CPaD was conducted on a subset of 34 plots. The study revealed the following findings: (i) Perceptions on CPaD with respect to their distribution across altitudes and perceived impact are partially concordant among farmers, experts and field observations (ii) There are discrepancies among farmers and experts regarding management practices and the development of CPaD issues of the previous years. (iii) Field observations comparing CPaD in different altitudes and production systems indicate ambiguity of the role of shade trees. According to the locality-specific variability in CPaD pressure as well as in FPK, the importance of developing spatially variable and

Estimation of the burden of chronic and allergic pulmonary aspergillosis in India.

Directory of Open Access Journals (Sweden)

Ritesh Agarwal

Full Text Available It would be of considerable interest to clinicians if the burden of chronic pulmonary aspergillosis (CPA and allergic bronchopulmonary aspergillosis (ABPA in India were known. Herein, we estimate the burden of CPA following pulmonary tuberculosis (PTB, and ABPA (and severe asthma with fungal sensitization [SAFS] complicating asthma.We used the population estimates for India from the 2011 census data. The burden of asthma was estimated using three different methods (Global Initiative against Asthma [GINA] report statement, World Health Survey [WHS] estimates, Indian study on the epidemiology of asthma and chronic bronchitis [INSEARCH]. Global and India-specific figures were used for calculating the prevalence of ABPA and SAFS. The World Health Organization estimates were used for calculating PTB rates while the frequency of CPA was assessed from a previously published scoping review. Sensitivity analysis was performed to determine the burden in various scenarios.The total Indian population in 2011 was 1.2 billion. The asthma prevalence in adults was estimated at about 27.6 (range, 17-30 million. The burden of ABPA ranged from 0.12-6.09 million with different assumptions (best estimate, 1.38 [range, 0.86-1.52] million. The prevalence of SAFS was approximated at about 0.52-1.21 million (best estimate, 0.96 [range, 0.6-1.06] million. The incident TB cases were about 2.1 million while the annual incidence of CPA varied 27,000-0.17 million cases, with different estimates. If the mortality of CPA is estimated as 15% annually, the 5-year prevalence of CPA was placed at 290,147 cases with 5-year prevalence rate being 24 per 100,000.There is a significant burden of ABPA, SAFS and CPA in India. Prospective community-based studies are required to accurately determine the prevalence of these disorders.

Towards a Collaborative Research: A Case Study on Linking Science to Farmers' Perceptions and Knowledge on Arabica Coffee Pests and Diseases and Its Management.

Science.gov (United States)

Liebig, Theresa; Jassogne, Laurence; Rahn, Eric; Läderach, Peter; Poehling, Hans-Michael; Kucel, Patrick; Van Asten, Piet; Avelino, Jacques

2016-01-01

The scientific community has recognized the importance of integrating farmer's perceptions and knowledge (FPK) for the development of sustainable pest and disease management strategies. However, the knowledge gap between indigenous and scientific knowledge still contributes to misidentification of plant health constraints and poor adoption of management solutions. This is particularly the case in the context of smallholder farming in developing countries. In this paper, we present a case study on coffee production in Uganda, a sector depending mostly on smallholder farming facing a simultaneous and increasing number of socio-ecological pressures. The objectives of this study were (i) to examine and relate FPK on Arabica Coffee Pests and Diseases (CPaD) to altitude and the vegetation structure of the production systems; (ii) to contrast results with perceptions from experts and (iii) to compare results with field observations, in order to identify constraints for improving the information flow between scientists and farmers. Data were acquired by means of interviews and workshops. One hundred and fifty farmer households managing coffee either at sun exposure, under shade trees or inter-cropped with bananas and spread across an altitudinal gradient were selected. Field sampling of the two most important CPaD was conducted on a subset of 34 plots. The study revealed the following findings: (i) Perceptions on CPaD with respect to their distribution across altitudes and perceived impact are partially concordant among farmers, experts and field observations (ii) There are discrepancies among farmers and experts regarding management practices and the development of CPaD issues of the previous years. (iii) Field observations comparing CPaD in different altitudes and production systems indicate ambiguity of the role of shade trees. According to the locality-specific variability in CPaD pressure as well as in FPK, the importance of developing spatially variable and relevant

Towards a Collaborative Research: A Case Study on Linking Science to Farmers' Perceptions and Knowledge on Arabica Coffee Pests and Diseases and Its Management.

Directory of Open Access Journals (Sweden)

Theresa Liebig

Full Text Available The scientific community has recognized the importance of integrating farmer's perceptions and knowledge (FPK for the development of sustainable pest and disease management strategies. However, the knowledge gap between indigenous and scientific knowledge still contributes to misidentification of plant health constraints and poor adoption of management solutions. This is particularly the case in the context of smallholder farming in developing countries. In this paper, we present a case study on coffee production in Uganda, a sector depending mostly on smallholder farming facing a simultaneous and increasing number of socio-ecological pressures. The objectives of this study were (i to examine and relate FPK on Arabica Coffee Pests and Diseases (CPaD to altitude and the vegetation structure of the production systems; (ii to contrast results with perceptions from experts and (iii to compare results with field observations, in order to identify constraints for improving the information flow between scientists and farmers. Data were acquired by means of interviews and workshops. One hundred and fifty farmer households managing coffee either at sun exposure, under shade trees or inter-cropped with bananas and spread across an altitudinal gradient were selected. Field sampling of the two most important CPaD was conducted on a subset of 34 plots. The study revealed the following findings: (i Perceptions on CPaD with respect to their distribution across altitudes and perceived impact are partially concordant among farmers, experts and field observations (ii There are discrepancies among farmers and experts regarding management practices and the development of CPaD issues of the previous years. (iii Field observations comparing CPaD in different altitudes and production systems indicate ambiguity of the role of shade trees. According to the locality-specific variability in CPaD pressure as well as in FPK, the importance of developing spatially variable

Construcción de un indicador para medir competencias básicas para la vida

Directory of Open Access Journals (Sweden)

Andrea Collado Chaves

2006-01-01

Full Text Available La necesidad de construir un indicador para cuantificar el nivel de Competencias Básicas para la Vida (CBV, nace con la evaluación los resultados de un proyecto dirigido a población joven. El propósito de ese proyecto es construir capital humano y empleabilidad en hombres y mujeres con edades entre 13 y 18 años, desertores o en riesgo de desertar del sistema educativo, sin empleo formal y que viven en ambientes de pobreza y exclusión. Una de las dimensiones de empleabilidad son las Competencias Básicas para la Vida. La dimensión de competencias básicas para la vida se refiere a aspectos de personalidad asociados con el desempeño del individuo en sus relaciones consigo mismo y con los demás. Los datos provienen de una investigación cuyo propósito consiste en evaluar los resultados de una intervención en población joven de comunidades pobres y excluidas. La construcción del indicador uso técnicas psicométricas para la validación de las distintas subdimensiones que pertenecen al concepto de competencias básicas para la vida. Según el marco conceptual este indicador está compuesto por seis dimensiones, la validación empírica hecha en este artículo incluye solamente cuatro de ellas, todas de carácter actitudinal. El indicador posee algunas ventajas en términos de la capacidad de discriminación debido a que su distribución tiende a ser normal. Sin embargo se ve afectaba por valores extremos a la izquierda del promedio y valores modales a una desviación estándar (positiva del promedio. Estos resultados serán útiles para discusiones futuras sobre los puntos de corte (baremos, el comportamiento del indicador cuando se correlaciona con deseabilidad social y la integración de la dimensión de Competencias Básicas para la Vida en el indicador de empleabilidad.

Systematic examination of publicly-available information reveals the diverse and extensive corporate political activity of the food industry in Australia

Directory of Open Access Journals (Sweden)

Melissa Mialon

2016-03-01

Full Text Available Abstract Background The political influence of the food industry, referred to as corporate political activity (CPA, represents a potential barrier to the development and implementation of effective public health policies for non-communicable diseases prevention. This paper reports on the feasibility and limitations of using publicly-available information to identify and monitor the CPA of the food industry in Australia. Methods A systematic search was conducted for information from food industry, government and other publicly-available data sources in Australia. Data was collected in relation to five key food industry actors: the Australian Food and Grocery Council; Coca Cola; McDonald’s; Nestle; and Woolworths, for the period January 2012 to February 2015. Data analysis was guided by an existing framework for classifying CPA strategies of the food industry. Results The selected food industry actors used multiple CPA strategies, with ‘information and messaging’ and ‘constituency building’ strategies most prominent. Conclusions The systematic analysis of publicly-available information over a limited period was able to identify diverse and extensive CPA strategies of the food industry in Australia. This approach can contribute to accountability mechanisms for NCD prevention.

[Prognostic factors after cardiac arrest. Usefulness of early video-electroencephalogram].

Science.gov (United States)

Arméstar, Fernando; Becerra Cuñat, Juan Luis; León Chan, Yariela; Mesalles Sanjuan, Eduard; Moreno, José Antonio; Jiménez González, Marta; Roca, Josep

2015-05-08

Predictors of unfavorable outcome in patients after cardiopulmonary arrest (CPA) are important to make decisions about the limitation of therapeutic efforts. The aim was to analyze the clinical variables in the prognosis of patients recovered after CPA. Retrospective study on comatose patients with recovered CPA. The variables were: age, sex, Glasgow Coma Score (GCS), pupillary light reflex, other variables related to CPA (cause, duration, witnessed or not witnessed), myoclonic status and electroencephalographic (EEG) patterns. Fifty patients were studied. The variables associated with mortality were the absence of pupillary light reflex (hazard ratio [HR] 0.277, 95% confidence interval [95% CI] 0.103-0.741, P=.01), a low GCS (HR 0.701, 95% CI 0.542-0.908, P=.007) and myoclonic state (HR 0.38, 95% CI 0.176-0.854, P=.01). We evaluated the EEG patterns in 22 patients. No statistical significance was observed. The absence of pupillary light reflex, a low GCS and myoclonic state are prognostic factors in patients recovered after a CPA. The EEG patterns showed a nonsignificant association with prognosis. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

Rapid Detection of Prunus Necrotic Ringspot Virus by Reverse Transcription-cross-priming Amplification Coupled with Nucleic Acid Test Strip Cassette.

Science.gov (United States)

Huo, Ya-Yun; Li, Gui-Fen; Qiu, Yan-Hong; Li, Wei-Min; Zhang, Yong-Jiang

2017-11-23

Prunus necrotic ringspot virus (PNRSV) is one of the most devastating viruses to Prunus spp. In this study, we developed a diagnostic system RT-CPA-NATSC, wherein reverse transcription-cross-priming amplification (RT-CPA) is coupled with nucleic acid test strip cassette (NATSC), a vertical flow (VF) visualization, for PNRSV detection. The RT-CPA-NATSC assay targets the encoding gene of the PNRSV coat protein with a limit of detection of 72 copies per reaction and no cross-reaction with the known Prunus pathogenic viruses and viroids, demonstrating high sensitivity and specificity. The reaction is performed on 60 °C and can be completed less than 90 min with the prepared template RNA. Field sample test confirmed the reliability of RT-CPA-NATSC, indicating the potential application of this simple and rapid detection method in routine test of PNRSV.

Synthesis and characterization of acrylate copolymer containing fluorescein functional group

Energy Technology Data Exchange (ETDEWEB)

Hui, Guodong; Huang, Weiyun; Song, Yunzhao; Chen, Deben; Zhong, Anyong [Sichuan University, Chengdu (China)

2013-08-15

We report a novel method to fabricate fluorescent polymer (F-CPA) based on the esterification between acrylate copolymer (CPA) and fluorescein using N, N-dicyclohexylcarbodiimide (DCC)/4-dimethylaminopyridine (DMAP) as catalyst. The resulting copolymer was characterized by Fourier transform-infrared spectroscopy (FT-IR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), ultraviolet-visible spectroscopy (UV-Vis) and fluorescence spectroscopy. In addition, the influences of concentration, solvents, pH and metal cations (Cu{sup 2+}, Fe{sup 3+} and Zn{sup 2+}) on the fluorescent behaviors of F-CPA are discussed in detail. All those observations suggest that the synthesized F-CPA is an excellent luminescent macromolecular material with simple synthesis method and excellent solubility. Moreover, its sensitive fluorescence response behaviors to solvents, pH and metal cations make it to become a polymer-based probe.

Central diabetes insipidus following cardiopulmonary arrest in a dog.

Science.gov (United States)

Bellis, Tara; Daly, Meredith; Davidson, Benjamin

2015-01-01

To describe a clinical case of transient central diabetes insipidus (CDI) occurring post cardiopulmonary arrest (CPA) in a dog. An 8-week-old dog presented for intensive care after successful resuscitation following CPA. The patient exhibited neurologic deficits at initial presentation and over the following days developed marked polyuria, isosthenuria, and low urine osmolality. Treatment with synthetic vasopressin resulted in a reduction in urine output, increase in urine specific gravity (>50%), and increase in urine osmolality, suggesting a diagnosis of partial CDI. Clinical signs resolved over the following weeks and treatment was discontinued. CPA has been described as a cause of ischemic injury to the pituitary gland resulting in CDI in people. To the authors' knowledge, this is the first report of a dog developing transient partial CDI following CPA and successful resuscitation. © Veterinary Emergency and Critical Care Society 2015.

R7T7 glass alteration in the presence of mortar: effect of the cement grade

International Nuclear Information System (INIS)

Andriambololona, Z.; Godon, N.; Vernaz, E.

1991-01-01

R7T7 glass alteration was investigated in the presence of four mortars prepared from four different cement grades: 'CPA' Portland cement (mortar M1), CPA with pozzolana additive (M2), CPA with amorphous silica additive (M3) and 'CLK' blast furnace slag cement (M4). Glass specimens were also altered in Volvic mineral water and in a cement effluent. Glass corrosion in the cement media was greater than in Volvic water, but well below what could be expected from the high pH (approx 12.5). The relatively low alteration was probably related to the protective action of the calcium-enriched gel layer that formed at the glass surface. The glass corrosion rate was 2 to 3 times lower with cement containing pozzolana or silica gel additives or with CLK cement than with CPA cement alone. 8 refs., 8 figs

Experimental determination and modeling of the phase behavior for the direct synthesis of dimethyl carbonate from methanol and carbon dioxide

DEFF Research Database (Denmark)

Tsivintzelis, Ioannis; Musko, Nikolai E.; Baiker, Alfons

2013-01-01

to predict the phase behavior of the multicomponent systems. It was shown that CPA is capable of predicting the phase behavior of such complex systems containing polar and associating components at high temperatures and pressures with reasonable accuracy considering the non-ideality of such mixtures......-Plus-Association (CPA) equation of state was applied to model the phase behavior of the experimentally studied systems. In this regard, the CPA binary interaction parameters were estimated based on experimental data for the corresponding binary systems available in the literature, and subsequently the model was applied...

Propuesta metodológica para hacer un diagnóstico de la Educación para el Desarrollo

Directory of Open Access Journals (Sweden)

Francisco Javier Gómez González

2012-01-01

Full Text Available El presente artículo quiere dar a conocer el diseño metodológico para la elaboración de un diagnóstico de situación de la educación para el desarrollo en Castilla y León, que se ha ideado desde el Observatorio de Cooperación Internacional de la Universidad de Valladolid con el fin de que el conocimiento sobre la situación actual de la educación para el desarrollo en Castilla y León sirva de base para la formulación de una futura estrategia de acción en educación para el desarrollo en la Comunidad.

Requisitos de clientes para o desenvolvimento de um implemento a fim de fechar taipas abertas para drenagem

Directory of Open Access Journals (Sweden)

Ulisses Giacomini Frantz

2015-04-01

Full Text Available O arroz irrigado é cultivado na maior parte do RS com aplainamento da superfície do solo em desnível e sistema de cultivo mínimo. Com a semeadura em solo seco, há necessidade de conformar drenos, que cortam transversalmente as taipas, na área de cultivo. Para o estabelecimento da lâmina de água definitiva, essas taipas abertas para drenagem devem ser fechadas e, para essa finalidade, não existe um equipamento específico que execute tal atividade com devida agilidade e qualidade, sendo necessário o desenvolvimento de um implemento com este fim. Ainda, para o processo de desenvolvimento de máquinas agrícolas, faz-se necessário o levantamento de uma série de informações. Na fase de projetação, essas informações são necessárias para o estabelecimento das necessidades dos clientes/usuários e dos requisitos dos clientes, para posteriormente serem transformadas em requisitos de projeto e estabelecidas as especificações de projeto. Desse modo, este trabalho objetivou determinar os requisitos dos clientes, a partir das suas necessidades, para o projeto de um implemento com a função de fechamento de taipas abertas para drenagem no arroz irrigado. As informações foram levantadas a partir de pesquisas bibliográficas e aplicação de questionários a futuros clientes/usuários. Como resultados, foram identificadas as necessidades dos clientes, assim como 25 requisitos de clientes

Hiperacumulación de metales : ¿una ventaja para la planta y para el hombre?

OpenAIRE

Llugany i Ollé, Mercè; Tolrà Pérez, Roser; Poschenrieder, Charlotte; Barceló Coll, Juan

2007-01-01

La hiperacumulación es la capacidad que tienen algunas plantas para concentrar metales en sus tejidos a niveles muy por encima de los normales sin presentar síntomas de toxicidad. Estas plantas hiperacumuladoras han desarrollado mecanismos internos de tolerancia a la toxicidad por metales. Esta peculiaridad las hace útiles para el hombre como herramienta en las nuevas tecnologías de fitoremediación. Sin embargo, ¿cual es el beneficio de esta hiperacumulación de metales para la propia planta? ...

Hiperacumulación de metales: ¿una ventaja para la planta y para el hombre?

OpenAIRE

M. Llugany; R. Tolrà; C. Poschnrieder; J. Barceló

2007-01-01

La hiperacumulación es la capacidad que tienen algunasplantas para concentrar metales en sus tejidos a niveles muy por encima de los normales sin presentar síntomas de toxicidad. Estas plantas hiperacumuladoras han desarrollado mecanismos internos de tolerancia a la toxicidad por metales. Esta peculiaridad las hace útiles para el hombre como herramienta en las nuevas tecnologías de fitoremediación. Sin embargo, ¿cual es el beneficio de esta hiperacumulación de metales para la propia planta? S...

¿Para que la historia?

OpenAIRE

Jaime Jaramillo Uribe

1998-01-01

Para qué sirve la historia?. ¿Puede el conocimiento del pasado darnos pautas para comprender el presente? Sobre este, como sobre tantos problemas teóricos de la historia, se han realizado largos e inacabados debates entre historiadores y filósofos. En este ensayo se acepta como eficaz la hipótesis de que conocer el origen y el desarrollo de un proceso es buen fundamento para explicarse una situación final. En el caso de la historia colombiana, se parte de la base de que al producirse la indep...

Subvenciones para instituciones Directrices para gastos de ...

International Development Research Centre (IDRC) Digital Library (Canada)

IDRC CRDI

División de Administración de Subvenciones ... En la Parte 2 del Acuerdo de Subvención estándar de IDRC se incluyen los límites ... pagar los costos de sustitución (tiempo libre para personal académico) de los investigadores principales.

Zoneamento agroclimático da palma forrageira (Opuntia sp. para o estado da Paraíba

Directory of Open Access Journals (Sweden)

Bergson G. Bezerra

2014-07-01

Full Text Available A palma forrageira tornou-se, ao longo dos anos, uma importante alternativa forrageira no semiárido brasileiro (SAB principalmente em longos períodos de estiagens. Apesar de sua magnitude para a agropecuária, seu cultivo tem dispensando tratos culturais básicos e embasamento técnico-científico quanto às suas exigências climáticas. Assim, o principal objetivo deste estudo foi elaborar o zoneamento agroclimático da cultura da palma forrageira (Opuntia sp. para o estado da Paraíba. O zoneamento agroclimático da palma forrageira foi elaborado com base nos indicadores climáticos delineados na literatura e nos dados climatológicos de precipitação e temperatura (média, máxima e mínima de 97 localidades do estado da Paraíba. De acordo com os resultados obtidos, a mesorregião da Borborema é a que apresenta as condições climáticas mais favoráveis para o cultivo da palma forrageira. As mesorregiões do Agreste, Sertão e a parte do Litoral, são aptas porém com restrições. No entanto, recomenda-se o cultivo da palma forrageira em todo o território do estado da Paraíba, exceto para a parte costeira da mesorregião do Litoral e região em torno de Areia. Em ambos os casos a inaptidão ocorre em função do excesso de precipitação.

Plan estratégico para la empresa Global Logistics (GL) para el periodo 2017-2019

OpenAIRE

Castello Manky, Luis Fernando; Grados Iturrizaga, Miguel Augusto; Hudson Okumura, Ciro

2017-01-01

El presente trabajo de investigación tiene como finalidad el desarrollo de un plan estratégico para la empresa Global Logistics (GL) para los años 2017 a 2019. Inicia con el análisis y diagnóstico situacional, donde se analiza el macroentorno en base al análisis PESTEL y luego se procede a analizar la industria considerando las cinco fuerzas de Porter, para, finalmente, determinar las oportunidades y amenazas que enfrenta la empresa. Una vez concluido el análisis y diagnóstico situacional, se...

Procedimiento para el cierre de canteras de materiales para construcción en Cuba

Directory of Open Access Journals (Sweden)

Julio Montero-Matos

2016-03-01

Full Text Available Con el propósito de facilitar a los concesionarios de canteras de materiales para la construcción una herramienta metodológica para efectuar el cierre de estas y garantizar una minería sostenible se propuso un procedimiento en seis etapas a partir del diagnóstico realizado en 22 canteras, ubicadas en tres regiones mineras cubanas. El procedimiento busca disminuir los impactos ambientales provocados por la explotación de las canteras y ofrecer a la industria un estándar para lograr uniformidad en la planificación y ejecución del cierre con un costo mínimo.

Desenvolvimento de filmes biodegradáveis para cobertura de solo, ensacamento de frutos e sacos para mudas

OpenAIRE

Ana Paula Bilck

2010-01-01

Filmes plásticos de polietileno e polipropileno derivados do petróleo são amplamente utilizados na agricultura para a confecção de estufas, sacos para produção de mudas e filmes para cobertura do solo. Estes filmes constituem um sério problema ambiental, pois devido ao seu elevado peso molecular e propriedades hidrofóbicas, possuem alta estabilidade química, levando um longo tempo para se decompor totalmente e também são de difícil reciclagem. A utilização de polímeros biodegradáveis é uma al...

Taller para desarrollar la creatividad

OpenAIRE

MARTÍNEZ GUEROLA, BEATRIZ

2015-01-01

[ES] Partimos de la base de que la creatividad es una capacidad realmente valiosa, no solo para el ámbito artístico, si no para cualquier aspecto de la vida. Este proyecto está enfocado a un taller diseñado para que a partir de técnicas de expresión gráfico-plásticas podamos estimular y desarrollar la creatividad, principalmente en niños de tercer ciclo de primaria. Con este proyecto relacionamos el arte y la creatividad que se asocia a esté con la educación. Martínez Guerola, B. (2015). T...

Monitoring the behaviour of 4-ketocyclophosphamide versus cyclophosphamide during capillary gas chromatography by mass spectrometry

NARCIS (Netherlands)

Bruijn, de E.A.; Oosterom, van A.T.; Leclercq, P.A.; Haan, de J.W.; Ven, van de L.J.M.; Tjaden, U.R.

1987-01-01

Capillary Gas Chromatography (CGC) is capable of determining underivatized cyclophosphamide (CPA) using SCOT OV 275 columns. Then CPA is subjected to in situ degradation resulting in formation of a cyclization product which can be determined selectively in biological fluids. In routine bioanalysis

Sistema solar para aquecimento ambiente e aquecimento de piscinas: uma solução promissora para climas do Sul da Europa

OpenAIRE

Carvalho, M. J.; Neves, Ana

2006-01-01

A avaliação do sistema apresentado neste trabalho foi focada em sistemas que podem fornecer água quente, aquecimento ambiente e aquecimento de piscinas, e que são projectados para climas do Sul da Europa, especialmente para habitações uni-familiares. Pelas características climáticas do Sul da Europa, o aquecimento ambiente é apenas necessário para um curto período do ano, sendo para esta avaliação considerado um período de seis meses para aquecimento ambiente e um período de seis meses para a...

MODELO PARA DETERMINAR FUNÇÕES TRANSFERÊNCIA PARA ANÁLISE DE ESTABILIDADE DE VANTS

Directory of Open Access Journals (Sweden)

Igor Mayer Soares

2017-01-01

Full Text Available Neste trabalho foi apresentado um modelo para determinar as funções de transferência para análise da estabilidade longitudinal de Veículos Aéreos Não Tripulados (VANT através do desenvolvimento simplificado das equações do movimento de aeronaves. O sistema foi simplificado considerando que o motor e o arrasto na superfície de comando não influenciam na dinâmica do veículo, pois o mesmo é significativamente menor que um avião. Analisamos também a resposta em função do tempo para as deflexões das superfícies de comando. Nos resultados apresentados é possível perceber que mesmo simples, o modelo oferece uma boa aproximação para análise dinâmica de VANTs e predizer sua estabilidade e qualidade de voo.

Modeling Phase Equilibria for Acid Gas Mixtures using the Cubic-Plus-Association Equation of State. 3. Applications Relevant to Liquid or Supercritical CO2 Transport

DEFF Research Database (Denmark)

Tsivintzelis, Ioannis; Ali, Shahid; Kontogeorgis, Georgios

2014-01-01

density data for both CO2 and CO2–water and for vapor–liquid equilibrium for mixtures of CO2 with various compounds present in transport systems. In all of these cases we consider various possibilities for modeling CO2 (inert, self-associating using two-, three-, and four sites) and the possibility......The CPA (cubic-plus-association) equation of state is applied in this work to a wide range of systems of relevance to CO2 transport. Both phase equilibria and densities over extensive temperature and pressure ranges are considered. More specifically in this study we first evaluate CPA against......” for applying CPA to acid gas mixtures. The overall conclusion is that CPA performs satisfactorily; the model in most cases correlates well binary data and predicts with good accuracy multicomponent vapor–liquid equilibria. Among the various approaches investigated, the best ones are when cross association...

MODELO PARA LA CREACIÓN DEL CONOCIMIENTO PARA PYMES

Directory of Open Access Journals (Sweden)

Marino Valencia Rodríguez

2009-01-01

Full Text Available La creciente importancia del conocimiento, como nuevo factor de producción, hace que la creación y transferencia se convierta en una de las principales prioridades de las organizaciones. El presente artículo describe tanto los fundamentos de la teoría de los recursos y capacidades de la empresa como el enfoque de la gestión del conocimiento, con sus procesos de generación y transferencia del conocimiento. Estos sirven de guía básica teórica para alcanzar el siguiente objetivo: Diseñar un modelo de generación y transferencia de conocimiento para los procesos de dirección, gestión humana y del conocimiento para PyMES, con el fin de que éstas alcancen mayores niveles de competitividad. El modelo se diseña, a partir del direccionamiento estratégico de la organización. Está conformado por tres etapas, articuladas con elementos y actividades. Las acciones se enfocan en dos factores clave de éxito: la cultura organizacional y la formación. La utilización del modelo permitirá a las PyMES optimizar los recursos y capacidades disponibles, lo cual se refleja en el desempeño del trabajador y en el fortalecimiento de la cultura organizacional.

Flora da Paraíba, Brasil: Loganiaceae Flora of Paraíba, Brazil: Loganiaceae

Directory of Open Access Journals (Sweden)

Kiriaki Nurit

2005-06-01

Full Text Available Neste trabalho apresenta-se o tratamento taxonômico da família Loganiaceae, como parte do projeto "Flora da Paraíba", que vem sendo realizado com o objetivo de identificar e catalogar as espécies da flora local. Realizouse coletas e observações de campo para as identificações, descrições e ilustrações botânicas que foram efetuadas após estudos morfológicos, com o auxílio da bibliografia especializada, complementados pela análise de fotos de tipos, espécimes dos herbários EAN, JPB e IPA, e comparação com material identificado por especialistas. Registrou-se para a Paraíba quatro espécies: Spigelia anthelmia L., com ampla distribuição, e três espécies de Strychnos, somente coletadas em remanescentes de Mata Atlântica, S. atlantica Krukoff & Barneby, S. parvifolia A. DC. e S. trinervis (Vell. Mart.This work constitutes a taxonomic treatment of the Loganiaceae family as part of the project "Flora da Paraíba", which have been carried out with the objective to identify and catalogue the species of the local flora. The botanical identifications and illustrations were made by morphological studies supported by bibliography, analysis of the types, specimens from herbaria EAN, JPB and IPA, and comparison with samples previously identified by specialists, complemented by field observations. Four species of Loganiaceae belonging two genera were found in State of Paraíba: Spigelia anthelmia L. that has wide distribution and three species of Strychnos, found on remains of Atlantic forest, which are S. atlantica Krukoff & Barneby, S. parvifolia A. DC. and S. trinervis (Vell. Mart.

Educación para emprender una alternativa para el siglo XXI

Directory of Open Access Journals (Sweden)

Luis Gerardo Rodríguez Gómez

2015-05-01

Full Text Available RESUMEN El artículo describe la experiencia educativa del programa Físico- Deportivo orientado a estimular la actitud para emprender dentro de una concepción de forma integral, mediante Asignaturas de contenido Sico- físico, como parte del desarrollo curricular en Facultades de Administración de Empresas e ingeniería de Sistemas en la Escuela de Administración de Negocios (EAN. El desarrollo temático hace énfasis en un proceso orientado  a superar formas de educación encaminadas al logro de habilidades técnicas para el ejercicio de un empleo y propone desde  la educación delas conductas  motrices, modos de encausar la energía sicosomática con el fin de asimilar la incertidumbre del momento histórico que se vive en los países de lento desarrollo, para corresponder a un mundo que empuña la bandera de la diversidad, el cambio acelerado y la competencia tecnológica.

La carrera profesional para el profesorado

Directory of Open Access Journals (Sweden)

José Gimeno Sacristán

2010-01-01

Full Text Available La carrera del profesorado es un instrumento para el reconocimiento del mérito de los profesores en el desarrollo de su profesionalidad -lo cual supone atender a la mejora de sus capacidades cognitivas como a su competencia reflexivo-práctica- cuyos fines son la motivación para el ejercicio de sus funciones, reforzar su compromiso con la educación en general y como forma de reconocer con justicia el mérito de los mejores profesionales. Desde un punto de vista estrictamente educativo, la carrera debe servir para la mejora de las prácticas de enseñanza que incidan en la mejora de los aprendizajes. Esta pretensión nos exige explicitar los criterios para determinar lo que entendemos como buenas prácticas y precisar los criterios para su evaluación. La complejidad de la enseñanza requiere metodologías adecuadas para abordar procesos de índole cualitativa. La regulación de la carrera docente tiene que superar tanto el cuantitativismo fácil en los métodos y la regulación burocrática de niveles de calidad, así como contemplar un conjunto de incentivos no solamente salariales.

Control of foodborne pathogens on fresh-cut fruit by a novel strain of Pseudomonas graminis.

Science.gov (United States)

Alegre, Isabel; Viñas, Inmaculada; Usall, Josep; Teixidó, Neus; Figge, Marian J; Abadias, Maribel

2013-06-01

The consumption of fresh-cut fruit has substantially risen over the last few years, leading to an increase in the number of outbreaks associated with fruit. Moreover, consumers are currently demanding wholesome, fresh-like, safe foods without added chemicals. As a response, the aim of this study was to determine if the naturally occurring microorganisms on fruit are "competitive with" or "antagonistic to" potentially encountered pathogens. Of the 97 and 107 isolates tested by co-inoculation with Escherichia coli O157:H7, Salmonella and Listeria innocua on fresh-cut apple and peach, respectively, and stored at 20 °C, seven showed a strong antagonistic capacity (more than 1-log unit reduction). One of the isolates, CPA-7, achieved the best reduction values (from 2.8 to 5.9-log units) and was the only isolate able to inhibit E. coli O157:H7 at refrigeration temperatures on both fruits. Therefore, CPA-7 was selected for further assays. Dose-response assays showed that CPA-7 should be present in at least the same amount as the pathogen to adequately reduce the numbers of the pathogen. From the results obtained in in vitro assays, competition seemed to be CPA-7's mode of action against E. coli O157:H7. The CPA-7 strain was identified as Pseudomonas graminis. Thus, the results support the potential use of CPA-7 as a bioprotective agent against foodborne pathogens in minimally processed fruit. Copyright © 2013 Elsevier Ltd. All rights reserved.

HIFU as a Neoadjuvant Therapy in Cancer Treatment

Science.gov (United States)

Zhong, P.; Xing, F.; Huang, X.; Zhu, H.; Lo, H. W.; Zhong, X.; Pruitt, S.; Robertson, C.

2011-09-01

To broaden the application spectrum of HIFU in cancer therapy, we performed a pilot experiment to evaluate the potential of using HIFU as a neoadjuvant therapy prior to surgery. Mice bearing wild-type B16F10 melanoma inoculated subcutaneously were either untreated (control) or treated by HIFU, CPA-7 or HIFU+CPA-7 before surgical resection of the primary tumor two days after HIFU treatment. The animals were then followed for four weeks or up to the humane endpoint to determine local recurrence, distant metastasis, and survival rate. The results demonstrate that animals treated by HIFU+CPA-7 (which is a small molecule that suppresses STAT3 activity) had a significantly lower recurrence rate, and slower growth of the recurrent tumor, with concomitantly higher survival rate, followed by those treated with CPA-7 and HIFU, respectively. Immunological assays revealed that CPA-7 treatment could significantly lower STAT3, and subsequently, Treg activities. In particular, the combination of HIFU and CPA-7 can induce a much stronger anti-tumor immune response than HIFU or surgery alone, as assessed by CTL and IFN-γ secretion. Overall, our results suggest that HIFU in combination with immunotherapy strategies has the potential to be used as a neoadjuvant therapy to prime the host with a strong anti-tumor immune response before surgical resection of the primary tumor. This multimodality, combinational therapy has the potential to greatly broaden the range of HIFU applications in cancer therapy with lower tumor recurrence and improved survival rate.

Tiempo para un cambio

Science.gov (United States)

Woltjer, L.

1987-06-01

En la reunion celebrada en diciembre dei ano pasado informe al Consejo de mi deseo de terminar mi contrato como Director General de la ESO una vez que fuera aprobado el proyecto dei VLT, que se espera sucedera hacia fines de este aAo. Cuando fue renovada mi designacion hace tres aAos, el Consejo conocia mi intencion de no completar los cinco aAos dei contrato debido a mi deseo de disponer de mas tiempo para otras actividades. Ahora, una vez terminada la fase preparatoria para el VLT, Y habiendose presentado el proyecto formalmente al Consejo el dia 31 de marzo, y esperando su muy probable aprobacion antes dei termino de este ano, me parece que el 10 de enero de 1988 presenta una excelente fecha para que se produzca un cambio en la administracion de la ESO.

7 CFR 1773.43 - Capital and equity accounts.

Science.gov (United States)

2010-01-01

... AGRICULTURE (CONTINUED) POLICY ON AUDITS OF RUS BORROWERS RUS Required Audit Procedures and Documentation... must include analyses of all stock transactions during the audit period. Based upon the CPA's determination of materiality, an appropriate sample of transactions must be selected for testing. The CPA's...

78 FR 42544 - Outer Continental Shelf (OCS), Gulf of Mexico (GOM), Oil and Gas Lease Sale, Western Planning...

Science.gov (United States)

2013-07-16

... Prepare a Supplemental Environmental Impact Statement (EIS) SUMMARY: Consistent with the regulations... 248; Central Planning Area (CPA) Lease Sales 227, 231, 235, 241, and 247, Final Environmental Impact... Supplemental Environmental Impact Statement (OCS EIS/EA BOEM 2013-0118) (WPA 233/CPA 231 Supplemental EIS). The...

The implementation of customer profitability analysis: a case study

NARCIS (Netherlands)

van Raaij, E.M.; Vernooij, M.J.A.; Vernooij, Maarten J.A.; van Triest, S.P.

2003-01-01

By using customer profitability analysis (CPA), firms can determine the profit contribution of customer segments and/or individual customers. This article presents an approach for the implementation of CPA. The implementation process is illustrated using a case study of a firm producing and selling

Characterization of toxigenic and atoxigenic Aspergillus flavus isolates from pistachio

Science.gov (United States)

Thirty eight Aspergillus flavus isolates collected from a pistachio orchard in California were analyzed for production of aflatoxin (AF), cyclopiazonic acid (CPA), vegetative compatibility groups (VCGs) and mating types. All toxigenic isolates produced both AFB1 and CPA. Twenty-one percent of the i...

Gastric serosal tear due to congenital pyloric atresia: A rare anomaly ...

African Journals Online (AJOL)

Congenital pyloric atresia (CPA) is a very rare malformation with unknown aetiology. It has has numerous complications including gastric perforation, aspiration pneumonia. Gastric perforations in newborns occur by three mechanisms: trauma, ischaemia, or spontaneous. Here, we report a newborn with CPA presenting with ...

Leasing: una alternativa de financiamiento para PYMES

OpenAIRE

Bedjan, María Belén

2008-01-01

En la actualidad las pequeñas y medianas empresas encuentran dificultades para acceder a las líneas tradicionales de créditos bancarios. Por otro lado las empresas necesitan actualizarse constantemente para poder ser competitivas en el mercado. Es aquí donde el leasing nace como una alternativa de financiación para las PyMEs. Este trabajo pretendió demostrar la conveniencia financiera del leasing con respecto a los préstamos bancarios para la compra de maquinarias agrícolas ...

Estrategia para elevar la motivación laboral; factor imprescindible para mejorar nuestra productividad.

Directory of Open Access Journals (Sweden)

Reina de los Ángeles Carballé Piñón

2015-12-01

Full Text Available Este trabajo "Estrategia para elevar la motivación laboral; factor imprescindible para mejorar nuestra productividad" resulta de la investigación realizada para tesis de maestría; se realizó el estudio de 2 entidades, nos permitió conocer las principales posiciones que sobre motivación existen, factores que la influencian, cómo incide en el desempeño laboral y que acciones diseñar para elevarla. Las 2 entidades seleccionadas, claves en el desempeño empresarial son un centro de interfase y un centro generador de conocimientos, nuestro objetivo principal es sugerir propuestas que eleven la motivación de los trabajadores del CIGET(centro de interfase y la Universidad de Sancti Spíritus(centro generador de conocimientos por desempeñar una mejor labor y lograr así aumento de la eficacia, eficiencia y productividad; este se concreta específicamente en determinar qué factores ocasionan desmotivación en los trabajadores del CIGET y la Universidad, identificar aquellos factores que realmente motivan a estas personas, de manera individual como colectivamente y trazar una estrategia con el objetivo de elevar la motivación de los trabajadores hacia la actividad que realizan y dotar a estos de herramientas para la identificación de actitudes positivas o negativas en el ámbito laboral y cómo potenciarlas o minimizarlas según sea el caso.

High-pressure vapor-liquid equilibria of systems containing ethylene glycol, water and methane - Experimental measurements and modeling

DEFF Research Database (Denmark)

Folas, Georgios; Berg, Ole J.; Solbraa, Even

2007-01-01

This work presents new experimental phase equilibrium measurements of the binary MEG-methane and the ternary MEG-water-methane system at low temperatures and high pressures which are of interest to applications related to natural gas processing. Emphasis is given to MEG and water solubility...... measurements in the gas phase. The CPA and SRK EoS, the latter using either conventional or EoS/G(E) mixing rules are used to predict the solubility of the heavy components in the gas phase. It is concluded that CPA and SRK using the Huron-Vidal mixing rule perform equally satisfactory, while CPA requires...

Fast identification of cyclopiazonic acid in milk by capillary electrophoresis

Directory of Open Access Journals (Sweden)

G.F. Greppi

2011-03-01

Full Text Available Cyclopiazonic acid (CPA (Figure 1 is a toxic, indole tetramic acid that was originally isolated from Penicillium cyclopium (Holzapfel, 1968 and subsequentely reported to be produced by numerous species of Penicillium and Aspergillus (Dorner et al., 1985. Natural occurrence of CPA has been reported in a variety of commodities including corn peanuts (Urano et al., 1992, cheese, millet, sunflower, and various feed and feedstuffs (Balachandranand Parthasarathy, 1996. The toxin has also been shown to accumulate in meat and eggs of chickens and the milk of sheep (Dorner et al., 1994 dosed with CPA...

Towards Predictive Association Theories

DEFF Research Database (Denmark)

Kontogeorgis, Georgios; Tsivintzelis, Ioannis; Michelsen, Michael Locht

2011-01-01

Association equations of state like SAFT, CPA and NRHB have been previously applied to many complex mixtures. In this work we focus on two of these models, the CPA and the NRHB equations of state and the emphasis is on the analysis of their predictive capabilities for a wide range of applications....... We use the term predictive in two situations: (i) with no use of binary interaction parameters, and (ii) multicomponent calculations using binary interaction parameters based solely on binary data. It is shown that the CPA equation of state can satisfactorily predict CO2–water–glycols–alkanes VLE...

Competencia para desarrollar la alfabetización digital

OpenAIRE

González Rodríguez, José Santiago; Navarrete Aguirre, Mariana; Molina Zacate, Ma. Gabriela

2011-01-01

Introducción, Objetivos Generales, Temario: (1) ¿Qué significa la competencia para desarrollar la alfabetización digital? (2) ¿Por qué es relevante que adquiera la competencia para desarrollar la alfabetización digital en mi formación? (3) ¿Cómo aprendo la competencia para desarrollar la alfabetización digital? (4) ¿Cómo aplico la competencia para desarrollar la alfabetización digital? (5) ¿Cómo puedo autoevaluar mi competencia para desarrollar la alfabetización digital (...

A systematic review of universal campaigns targeting child physical abuse prevention.

Science.gov (United States)

Poole, Mary Kathryn; Seal, David W; Taylor, Catherine A

2014-06-01

The purpose of this review was to better understand the impact of universal campaign interventions with a media component aimed at preventing child physical abuse (CPA). The review included 17 studies featuring 15 campaigns conducted from 1989 to 2011 in five countries. Seven studies used experimental designs, but most were quasi-experimental. CPA incidence was assessed in only three studies and decreased significantly in two. Studies also found significant reductions in relevant outcomes such as dysfunctional parenting, child problem behaviors and parental anger as well as increases in parental self-efficacy and knowledge of concepts and actions relevant to preventing child abuse. The following risk factors were most frequently targeted in campaigns: lack of knowledge regarding positive parenting techniques, parental impulsivity, the stigma of asking for help, inadequate social support and inappropriate expectations for a child's developmental stage. The evidence base for universal campaigns designed to prevent CPA remains inconclusive due to the limited availability of rigorous evaluations; however, Triple-P is a notable exception. Given the potential for such interventions to shift population norms relevant to CPA and reduce rates of CPA, there is a need to further develop and rigorously evaluate such campaigns. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Motivacao para o tratamento. Dados psicometricos da escala SOCRATES 8D e estrategias psicoterapeuticas para motivar para o tratamento

OpenAIRE

Janeiro, Luís; Faísca, Luís

2008-01-01

A motivação para o tratamento é considerada um factor fundamental para o processo de mudança e tratamento do toxicodependente. Prochaska, Diclemente, e Norcross (1992) consideram que a motivação que o sujeito possui no início do tratamento determina directamente os resultados alcançados no mesmo. Diclemente, Bellino, e Neavins (1999) acrescentam, ainda, que a estreita relação entre os resultados obtidos no tratamento e a motivação aquando do seu início pode ser medida pela formação precoce de...

La estrategia educativa 2020 o las limitaciones del Banco Mundial para promover el "aprendizaje para todos"

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Antoni Verger

2011-12-01

Full Text Available LA NUEVA Estrategia Educativa 2020 del Banco Mundial establece las prioridades de reforma educativa en países en vías de desarrollo para la década siguiente. El título explícito de la estrategia, Aprendizaje para Todos, es un claro reconocimiento de que, más allá de políticas centradas en el acceso, se debe hacer algo más para asegurar que la educación derive en experiencias positivas de aprendizaje. Sin embargo, como este artículo sostiene, las opciones de políticas explícitas y latentes en la Estrategia 2020 no son las más adecuadas para lograr el Aprendizaje para Todos. El artículo desarrolla tres tipos de argumentos al respecto. El primero se refiere al fuerte apego del Banco a un conocimiento disciplinario y un enfoque metodológico que es insuficiente para entender lo que aprenden los niños en la escuela y por qué. El segundo argumento se refiere al sesgo pro-mercado de la Estrategia por lo que respecta a la reforma del sector público y a nuevas formas de oferta educativa. En tercer lugar, el artículo señala las principales ausencias de la Estrategia, con especial atención a las omisiones relacionadas con la compleja relación entre educación y pobreza.

Inteligencia Emocional para tiempos de crisis

OpenAIRE

Fernández-Berrocal, Pablo

2014-01-01

La Inteligencia Emocional se concibe como un conjunto de habilidades, tanto básicas como complejas, dirigidas a “unificar las emociones y el razonamiento”, esto es, usar las emociones para facilitar el razonamiento y los procesos de pensamiento, y usar nuestro razonamiento para pensar de forma inteligente acerca de nuestras emociones (Mayer y Salovey, 1997). En concreto, la IE se define como una habilidad mental que incluye “la capacidad para percibir, valorar y expresar las emociones con...

GRASP para o PQA: um limite de aceitação para soluções iniciais

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Range Maria Cristina

2000-01-01

Full Text Available O Problema Quadrático de Alocação (PQA pertence à classe dos problemas NP-Hard e desafia os pesquisadores tanto em sua teoria quanto em sua parte computacional. Pela sua alta complexidade muitos métodos heurísticos têm sido desenvolvidos para tentar resolvê-lo aproximadamente. A metaheurística GRASP (greedy randomized adaptive search procedures se mostrou bastante eficiente. Neste trabalho, uma proposta para descartar soluções iniciais supostamente ruins é apresentada com base na normalização de custos calculadas num intervalo entre limites de solução. Para este GRASP restrito, foi observada uma redução do tempo computacional para encontrar as soluções ótimas ou soluções viáveis de boa qualidade quando comparado ao GRASP original.

Paisajes para un desarrollo sustentable y participativo

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Rafael Mata Olmo

2014-11-01

Para terminar, el texto recoge una experiencia de proyecto territorial de paisaje, la del Plan Insular de Menorca (Islas Baleares, España, aprobado en 2003. Se sintetizan sus determinaciones sobre la protección de determinados terrenos por sus altos valores paisajísticos, sus directrices para que las políticas sectoriales (turismo, agricultura, infraestructuras, etc. incorporen criterios paisajísticos, y sus iniciativas para la gestión y mejora del paisaje y para el fomento del acceso público a su contemplación y disfrute.

Sistema de realidad aumentada para aplicaciones Android

OpenAIRE

Fernández Sánchez, Natalia Mercedes

2012-01-01

El objetivo principal de este proyecto es la creación de un sistema de realidad aumentada para el sistema operativo Android con idea de que sea utilizado para la creación de un videojuego, pero que a su vez sea lo suficientemente versátil como para poder utilizarse en otro tipo de aplicaciones. De este objetivo principal podemos obtener los objetivos secundarios: - Conocer las características que ofrecen los teléfonos móviles y como éstas pueden ser aprovechadas para la crea...

Marco de referencia para el desarrollo de un sistema de apoyo para la toma de decisiones para la gestión de inventarios

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Carlos Alberto Castro Zuluaga

2014-01-01

Full Text Available El principal objetivo de este artículo es presentar un marco de referencia para desarrollar un sistema de soporte a la toma de decisiones para la gestión de inventarios que permita definir técnicamente los parámetros de una política de control de inventario específica. El modelo propuesto puede ser utilizado de forma genérica en casi cualquier tipo de industria, el cual incluye las entradas fundamentales, una descripción de los procesos internos requeridos y las salidas esperadas. En la investigación se utilizaron métodos inductivos-deductivos para definir el marco de referencia propuesto, el cual se fundamenta en dos indicadores clave en la gestión de inventario: niveles de servicio y costos. Finalmente, mediante una simulación es posible concluir que utilizando los parámetros teóricos para el modelo de inventario punto de reorden-cantidad fija, que son encontrados por el marco de referencia propuesto, se obtienen aproximadamente los valores esperados tanto de los niveles de servicio como de los costos.

Meios e fins do desenvolvimento para Celso Furtado

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Fabio Antonio de Campos

2014-10-01

Full Text Available O objetivo desse artigo é expor o conceito de desenvolvimento para Celso Furtado. Para tanto, nos interessa apresentar o desenvolvimento nacional como um fim em sua abordagem sobre a formação social brasileira Para atingir tal estágio, os meios para o autor seriam assegurados por um típico desenvolvimento capitalista. Dentro dessa problemática, mostraremos também o alcance e os limites dessa concepção para o caráter dependente e subdesenvolvido do capitalismo brasileiro.

Metodología para un proceso de planeación estratégica para las PYMES

OpenAIRE

Bonilla Zhindón, Daniela

2014-01-01

Todas las organizaciones, grandes, medianas, pequeñas, públicas y privadas, requieren de un plan estratégico estructurado para determinar las posiciones futuras en las que desean estar, por este motivo el propósito del presente estudio es construir una metodología transversal para el levantamiento de la planeación estratégica para el sector de calzado en la ciudad de Cuenca, mediante un análisis del estado en la que se encuentran las empresas en cuanto al proceso de planificación estratégica,...

Coccocypselum pulchellum (Rubiaceae, nuevo registro para Argentina

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Elsa L. Cabral

2007-01-01

Full Text Available Se cita Coccocypselum pulchellum por primera vez para Argentina, en Predio Guaraní, Misiones. Esta es la tercera especie de Coccocypselum registrada para la flora de Argentina junto con C. hasslerianum y C. lanceolatum. Se incluyen descripciones, ilustraciones y una clave para reconocer las tres especies argentinas de Coccocypselum.

Modelo para determinar as exigências de proteína para poedeiras Modelling protein utilization in laying hens

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Nilva Kazue Sakomura

2002-11-01

Full Text Available O objetivo do trabalho foi elaborar um modelo para estimar as exigências de proteína bruta (PB para poedeiras leves, usando o método fatorial. Para determinar as exigências de proteína bruta (PB para manutenção foi utilizada a técnica do balanço de nitrogênio. A exigência de proteína bruta para o ganho de peso foi determinada em função do conteúdo de nitrogênio na carcaça e a eficiência de utilização do nitrogênio da dieta. A exigência de PB, para produção de ovos, foi determinada considerando o teor de PB determinado nos ovos e a eficiência de deposição do nitrogênio no ovo. A partir dos valores das exigências para manutenção, para o ganho e produção foi elaborada uma equação para predizer as exigências diárias de PB (g/ ave/ dia para poedeiras: PB = 1,94. P0,75 + 0,48.G + 0,301.O, em que P = peso corporal (kg, G = ganho de peso diário (g/dia e O = massa de ovos produzida (g/ave/dia.The objective of this study was to determine a model for crude protein requirements (CP for laying hen by the factorial method. The protein maintenance requirement was determine by the nitrogen balance technique . The crude protein requirement for weight gain was determined based on body nitrogen content and nitrogen efficiency for body deposition. The crude protein requirement for egg production was determined based on the nitrogen content of eggs and nitrogen efficiency for egg deposition. Considering the requirements for maintenance, egg production and weight gain, it was elaborated a protein requirement model for laying hen: PB = 1.94xW.75 + 0.480xG + 0,301x E, where PB = requirement (g/bird/day, W = body weight (kg, G = daily weight gain (g/day and E = egg mass (g/bird/day.

Determination of asphaltene onset conditions using the cubic plus association equation of state

DEFF Research Database (Denmark)

Arya, Alay; von Solms, Nicolas; Kontogeorgis, Georgios M.

2015-01-01

The cubic-plus-association (CPA) equation of state (EoS) has already been proven to be a successful model for phase equilibrium calculations for systems containing associating components and has already been applied for asphaltene modeling by few researchers. In the present work, we apply the CPA...

Sensing of chlorpheniramine in pharmaceutical applications by sequential injector coupled with potentiometer

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Tawfik A. Saleh

2011-11-01

Full Text Available This paper reports on development of a system consisting of a portable sequential injector coupled with potentiometric unit for sensing of chlorpheniramine (CPA, based on the reaction of CPA with potassium permanganate in acidic media. Various experimental conditions affecting the potential intensity were studied and incorporated into the procedure. Under the optimum conditions, linear relationship between the CPA concentration and peak area was obtained for the concentration range of 0.1–50 ppm. The method reflects good recovery with relative standard deviation (RSD<3%. The detection limit was 0.05 ppm. The developed method was successfully applied for determination of CPA in pure form and in pharmaceutical dosage forms. The results, obtained using the method, are in accord with the results of the British pharmacopoeia method. In addition to its accuracy and precision, the method has the advantages of being simple, inexpensive and rapid. Keywords: Sensing, Flow injection, Chlorpheniramine, Potentiometry

Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications

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Nguyen Thi Hiep

2016-01-01

Full Text Available The purpose of this study was to fabricate chitosan/poly(vinyl alcohol/Ag nanoparticles (CPA gels with microwave-assistance for skin applications. Microwave irradiation was employed to reduce silver ions to silver nanoparticles and to crosslink chitosan (CS with polyvinyl alcohol (PVA. The presence of silver nanoparticles in CPA gels matrix was examined using UV-Vis spectroscopy, transmission electron microscopy, and X-ray diffraction. The interaction of CS and PVA was analysed by Fourier transform infrared spectroscopy. The release of silver ions was determined by atomic absorption spectrometry. The antimicrobial properties of CPA gels against P. aeruginosa and S. aureus were investigated using agar diffusion method. Finally, the biocompatibility and wound-healing ability of the gels were studied using fibroblast cells (in vitro and mice models (in vivo. In conclusion, the results showed that CPA gels were successfully fabricated using microwave irradiation method. These gels can be applied to heal an open wound thanks to their antibacterial activity and biocompatibility.

Awareness of Consumer Protection Act among Doctors in Udaipur City, India.

Science.gov (United States)

Singh, K; Shetty, S; Bhat, N; Sharda, A; Agrawal, A; Chaudhary, H

2010-01-01

To compare the awareness of provisions of consumer protection act among dental and medical professionals in Udaipur city, Rajasthan, India. In a cross sectional study, a total of 448 professionals (253 males, 195 females) belonging to dental (222) and medical (226) categories were surveyed using a self administered structured questionnaire. The questionnaire comprised of 22 questions about the awareness of consumer protection art (CPA) and whether these professionals were following the recommendations of CPA. The student's t-test, ANOVA test, and Scheffe's test were used as tests of significance. The awareness scores were significantly higher for medical professionals compared with those of dental professionals. Similarly, postgraduates showed more awareness in both the professions and it was found that private practitioners significantly have more awareness than the academic sector. Though medical professionals have more awareness of CPA compared to dental professionals, considering the present scenario, better knowledge of CPA is necessary for both professionals in order to be on the safer side.

Tuberculose em Salvador: custos para o sistema de saúde e para as famílias

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Costa João G

2005-01-01

Full Text Available OBJETIVO: A tuberculose é uma das maiores causas de mortalidade no mundo, porém seus efeitos econômicos são pouco conhecidos. O objetivo do estudo foi o de estimar os custos do tratamento e prevenção da tuberculose para o sistema de saúde (público e privado e para as famílias. MÉTODOS: O estudo foi realizado no município de Salvador, BA, em 1999. Os dados para estimação dos custos para o sistema de saúde foram coletados nas secretarias de saúde, centros de saúde e em uma entidade filantrópica. Os custos públicos e privados foram estimados pela metodologia da contabilidade de custos. Os dados de custos para as famílias foram coletados por meio de questionários e incluem despesas com transporte, alimentação e outros, bem como as perdas de renda associadas à doença. RESULTADOS: O custo médio para tratamento de um caso novo de tuberculose foi de aproximadamente R$186,00 (US$103; para o tratamento de um paciente multiresistente o custo foi 27 vezes mais alto. Os custos para o serviço público corresponderam a 65% em internações, 32% em tratamento e apenas 3% em prevenção. As famílias comprometeram cerca de 33% da sua renda com despesas relacionadas a tuberculose. CONCLUSÕES: Apesar do fato das famílias não terem que pagar por medicamentos e tratamento, dado que este serviço é oferecido pelo Estado, os custos familiares ligados a perda de rendimentos devido a doença foram muito elevados. A proporção utilizada em prevenção pelo serviço público é pequena. Um maior investimento em campanhas de prevenção poderia não somente diminuir o número de casos, mas também, levar a um diagnósticos precoce, diminuindo os custos associados à hospitalização. A falta de um sistema integrado de custos não permite a visualização dos custos nos diversos setores.

Sex differences between CRF1 receptor deficient mice following naloxone-precipitated morphine withdrawal in a conditioned place aversion paradigm: implication of HPA axis.

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Juan-Antonio García-Carmona

Full Text Available Extinction period of positive affective memory of drug taking and negative affective memory of drug withdrawal, as well as the different response of men and women might be important for the clinical treatment of drug addiction. We investigate the role of corticotropin releasing factor receptor type one (CRF1R and the different response of male and female mice in the expression and extinction of the aversive memory.We used genetically engineered male and female mice lacking functional CRF1R. The animals were rendered dependent on morphine by intraperitoneally injection of increasing doses of morphine (10-60 mg/kg. Negative state associated with naloxone (1 mg/kg s.c.-precipitated morphine withdrawal was examined by using conditioned place aversion (CPA paradigm. No sex differences for CPA expression were found in wild-type (n = 29 or CRF1R knockout (KO mice (n = 29. However, CRF1R KO mice presented less aversion score than wild-type mice, suggesting that CRF1R KO mice were less responsive than wild-type to continuous associations between drug administration and environmental stimuli. In addition, CPA extinction was delayed in wild-type and CRF1R KO male mice compared with females of both genotypes. The genetic disruption of the CRF1R pathway decreased the period of extinction in males and females suggesting that CRF/CRF1R is implicated in the duration of aversive memory. Our results also showed that the increase in adrenocorticotropic hormone (ACTH levels observed in wild-type (n = 11 mice after CPA expression, were attenuated in CRF1R KO mice (n = 10. In addition, ACTH returned to the baseline levels in males and females once CPA extinction was finished.These results suggest that, at least, CPA expression is partially due to an increase in plasma ACTH levels, through activation of CRF1R, which can return when CPA extinction is finished.

Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Cav3.2 in mice.

Science.gov (United States)

Ozaki, Tomoka; Matsuoka, Junki; Tsubota, Maho; Tomita, Shiori; Sekiguchi, Fumiko; Minami, Takeshi; Kawabata, Atsufumi

2018-01-15

Ca v 3.2 T-type Ca 2+ channel activity is suppressed by zinc that binds to the extracellular histidine-191 of Ca v 3.2, and enhanced by H 2 S that interacts with zinc. Ca v 3.2 in nociceptors is upregulated in an activity-dependent manner. The enhanced Ca v 3.2 activity by H 2 S formed by the upregulated cystathionine-γ-lyase (CSE) is involved in the cyclophosphamide (CPA)-induced cystitis-related bladder pain in mice. We thus asked if zinc deficiency affects the cystitis-related bladder pain in mice by altering Ca v 3.2 function and/or expression. Dietary zinc deficiency for 2 weeks greatly decreased zinc concentrations in the plasma but not bladder tissue, and enhanced the bladder pain/referred hyperalgesia (BP/RH) following CPA at 200mg/kg, a subeffective dose, but not 400mg/kg, a maximal dose, an effect abolished by pharmacological blockade or gene silencing of Ca v 3.2. Acute zinc deficiency caused by systemic N,N,N',N'-tetrakis-(2-pyridylmethyl)-ethylendiamine (TPEN), a zinc chelator, mimicked the dietary zinc deficiency-induced Ca v 3.2-dependent promotion of BP/RH following CPA at 200mg/kg. CPA at 400mg/kg alone or TPEN plus CPA at 200mg/kg caused Ca v 3.2 overexpression accompanied by upregulation of Egr-1 and USP5, known to promote transcriptional expression and reduce proteasomal degradation of Ca v 3.2, respectively, in the dorsal root ganglia (DRG). The CSE inhibitor, β-cyano-l-alanine, prevented the BP/RH and upregulation of Ca v 3.2, Egr-1 and USP5 in DRG following TPEN plus CPA at 200mg/kg. Together, zinc deficiency promotes bladder pain accompanying CPA-induced cystitis by enhancing function and expression of Ca v 3.2 in nociceptors, suggesting a novel therapeutic avenue for treatment of bladder pain, such as zinc supplementation. Copyright © 2017 Elsevier B.V. All rights reserved.

UNA PROPUESTA EVALUATIVA PARA ACTIVIDADES DE EDUCACIÓN AMBIENTAL PARA LA SOSTENIBILIDAD

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Rosa M. Medir Huerta

2016-01-01

Full Text Available El propósito de este artículo es presentar una propuesta evaluativa para ac - tividades de educación ambiental para la sostenibilidad en el ámbito escolar ofrecidas desde entidades externas a la escuela. Para ello, se realiza una eva - luación real de un programa educativo de una administración pública que se orienta al refuerzo del currículo de educación infantil, primaria y secundaria. El objetivo de la evaluación es diagnosticar la presencia, en las actividades estudiadas, de principios clave de la educación ambiental para la sosteni - bilidad identificados por el equipo de investigación a partir de referencias internacionales. La metodología es la investigación evaluativa de programas dentro del paradigma crítico de la investigación educativa y con herramientas de tipo cuantitativo. Se utiliza, básicamente, un cuestionario expresamente diseñado que valora la presencia y la ausencia de los principios establecidos de la educación ambiental para la sostenibilidad. Los resultados nos aportan nuevas informaciones acerca de las fortalezas y las debilidades del desarrollo de actividades de educación ambiental. Se llega a una valoración cuantificada de los principios definidos en tres grupos, según su necesidad de mejora, y se determina que los principios mejor tratados en las actividades son los que se relacionan con los contenidos disciplinares más clásicos, tratados con buenos y distintos métodos didácticos. En cambio, las debilidades detectadas se refieren a aspectos cruciales de la educación ambiental tales como experimentar nuevas sensaciones, aprender a buscar información, pensamiento crítico, sentimiento de pertenencia a un lugar, trabajo en colaboración, adquirir una visión global de la realidad, y reflexionar sobre la vida cotidiana y sobre el futuro deseado.

Computational Psycholinguistic Analysis and Its Application in Psychological Assessment of College Students

Science.gov (United States)

Kucera, Dalibor; Havigerová, Jana M.

2015-01-01

The paper deals with the issue of computational psycholinguistic analysis (CPA) and its experimental application in basic psychological and pedagogical assessment. CPA is a new method which may potentially provide interesting, psychologically relevant information about the author of a particular text, regardless of the text's factual (semantic)…

Cryopreservation of preimplantation embryos of cattle, sheep, and goats.

Science.gov (United States)

Youngs, Curtis R

2011-08-05

Preimplantation embryos from cattle, sheep, and goats may be cryopreserved for short- or long-term storage. Preimplantation embryos consist predominantly of water, and the avoidance of intracellular ice crystal formation during the cryopreservation process is of paramount importance to maintain embryo viability. Embryos are placed into a hypertonic solution (1.4 - 1.5 M) of a cryoprotective agent (CPA) such as ethylene glycol (EG) or glycerol (GLYC) to create an osmotic gradient that facilitates cellular dehydration. After embryos reach osmotic equilibrium in the CPA solution, they are individually loaded in the hypertonic CPA solution into 0.25 ml plastic straws for freezing. Embryos are placed into a controlled rate freezer at a temperature of -6°C. Ice crystal formation is induced in the CPA solution surrounding the embryo, and crystallization causes an increase in the concentration of CPA outside of the embryo, causing further cellular dehydration. Embryos are cooled at a rate of 0.5°C/min, enabling further dehydration, to a temperature of -34°C before being plunged into liquid nitrogen (-196°C). Cryopreserved embryos must be thawed prior to transfer to a recipient (surrogate) female. Straws containing the embryos are removed from the liquid nitrogen dewar, held in room temperature air for 3 to 5 sec, and placed into a 37°C water bath for 25 to 30 sec. Embryos cryopreserved in GLYC are placed into a 1 M solution of sucrose for 10 min for removal of the CPA before transfer to a recipient (surrogate) female. Embryos cryopreserved in EG, however, may be directly transferred to the uterus of a recipient.

Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice

Science.gov (United States)

Touil, Yasmine S.; Seguin, Johanne; Scherman, Daniel; Chabot, Guy G.

2011-01-01

Purpose The natural flavonoid fisetin was recently identified as a lead compound that stabilizes endothelial cell microtubules. In this study we investigated the antiproliferative and antiangiogenic properties of fisetin in vitro and in vivo. Methods Fisetin cytotoxicity was evaluated using Lewis lung carcinoma cells (LLC), endothelial cells and NIH 3T3 cells. Endothelial cell (EC) migration and capillary-like structure formation were evaluated using EAhy 926 cells. In vivo tumour growth inhibition studies were performed using LLC bearing mice treated with fisetin and/or cyclophosphamide (CPA). Results The fisetin IC50 was 59 μM for LLC and 77 μM for EC cells, compared to 210 μM for normal NIH 3T3 cells (24 h). Fisetin inhibited EC migration and capillary-like structure formation at non-cytotoxic concentrations (22–44 μM). In mice, fisetin inhibited angiogenesis assessed using the Matrigel plug assay. In LLC bearing mice, fisetin produced a 67% tumour growth inhibition (223 mg/kg, intraperitoneal), similar to the 66% produced by low dose CPA (30 mg/kg, subcutaneous). When fisetin and CPA were combined, however, a marked improvement in antitumour activity was observed (92% tumour growth inhibition), with low systemic toxicity. Tumour histology showed decreased microvessel density with either fisetin or CPA alone, and a dramatic decrease after the fisetin/CPA combination. Conclusions We have shown that fisetin not only displays in vitro and in vivo antiangiogenic properties, but that it can also markedly improve the in vivo antitumour effect of CPA. We propose that this drug combination associating a non-toxic dietary flavonoid with a cytotoxic agent could advantageously be used in the treatment of solid tumours. PMID:21069336

Dorsal hippocampal microinjection of chlorpheniramine reverses the anxiolytic-like effects of l-histidine and impairs emotional memory in mice.

Science.gov (United States)

Canto-de-Souza, L; Garção, D C; Romaguera, F; Mattioli, R

2015-02-05

Several findings have pointed to the role of histaminergic neurotransmission in the modulation of anxiety-like behaviors and emotional memory. The elevated plus-maze (EPM) test has been widely used to investigate the process of anxiety and also has been used to investigate the process of learning and memory. Visual cues are relevant to the formation of spatial maps, and as the hippocampus is involved in this task, experiment 1 explored this issue. Experiment 2 investigated the effects of intraperitoneal (i.p.) injections of l-histidine (LH, a precursor of histamine) and of intra-dorsal hippocampus (intra-DH) injections of chlorpheniramine (CPA, an H1 receptor antagonist) on anxiety and emotional memory in mice re-exposed to the EPM. Mice received saline (SAL) or LH i.p. and SAL or CPA (0.016, 0.052, and 0.16 nmol/0.1 μl) intra-DH prior to Trial 1 (T1) and Trial 2 (T2). No significant changes were observed in the number of enclosed-arm entries (EAE) in T1, an EPM index of general exploratory activity. LH had an anxiolytic-like effect that was reversed by intra-DH injections of CPA. T2 versus T1 analysis revealed that only the lower dose of CPA resulted in impaired emotional memory. Combined injections of LH and CPA revealed that higher doses of CPA impair emotional memory. Taken together, these results suggest that LH and H1 receptors present in the dorsal hippocampus are involved in anxiety-related behaviors and emotional memory in mice submitted to EPM. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Analysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model.

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Andrew T N Tebbenkamp

Full Text Available N-terminal fragments of mutant huntingtin (htt that terminate between residues 90-115, termed cleavage product A or 1 (cp-A/1, form intracellular and intranuclear inclusion bodies in the brains of patients with Huntington's disease (HD. These fragments appear to be proteolytic products of the full-length protein. Here, we use an HEK293 cell culture model to investigate huntingtin proteolytic processing; previous studies of these cells have demonstrated cleavage of htt to cp-A/1 like htt fragments.Recombinant N-terminal htt fragments, terminating at residue 171 (also referred to as cp-B/2 like, were efficiently cleaved to produce cp-A/1 whereas fragments representing endogenous caspase, calpain, and metalloproteinase cleavage products, terminating between residues 400-600, were inefficiently cleaved. Using cysteine-labeling techniques and antibody binding mapping, we localized the C-terminus of the cp-A/1 fragments produced by HEK293 cells to sequences minimally limited by cysteine 105 and an antibody epitope composed of residues 115-124. A combination of genetic and pharmacologic approaches to inhibit potential proteases, including γ-secretase and calpain, proved ineffective in preventing production of cp-A/1.Our findings indicate that HEK293 cells express a protease that is capable of efficiently cleaving cp-B/2 like fragments of htt with normal or expanded glutamine repeats. For reasons that remain unclear, this protease cleaves longer htt fragments, with normal or expanded glutamine expansions, much less efficiently. The protease in HEK293 cells that is capable of generating a cp-A/1 like htt fragment may be a novel protease with a high preference for a cp-B/2-like htt fragment as substrate.

Fatores sociodemográficos associados aos diferentes domínios da atividade física em adultos de etnia negra Sociodemographic factors associated with different domains of physical activity in adults of black ethnicity

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Francisco José Gondim Pitanga

2012-06-01

Full Text Available OBJETIVO: Analisar a prevalência e os fatores sociodemográficos associados aos diferentes domínios da atividade física em adultos de etnia negra. MÉTODOS: Estudo transversal com amostra de 2.305 adultos negros de 20 a 96 anos de idade, sendo 902 (39,1% homens, residentes na cidade de Salvador, BA, Brasil. Foram analisadas as variáveis sociodemográficas sexo, idade, escolaridade, nível socioeconômico (NSE, estado civil, discriminação racial no trabalho/escola (DRTE, em ambientes públicos (DRAPU e privados (DRAPR e percepção de policiamento (PPB/violência no bairro (PVB, além da atividade física total (AFT e em diferentes domínios: tempo livre (AFTL, trabalho (AFTR, deslocamento (AFDL e doméstico (AFDM. As associações foram analisadas por meio dos testes qui-quadrado, qui-quadrado de tendência e razão de prevalência (RP. Utilizou-se também regressão logística para estimar a razão de chances (RC com intervalo de confiança de 95%. RESULTADOS: As proporções de indivíduos ativos foram 39,1% para AFT, 11,2% para AFTL, 9,6% para AFTR, 23,7% para AFDL e 33,7% para AFDM. A AFT associou-se positivamente com escolaridade e inversamente com sexo masculino, idade maior que 60 anos e com não PPB. A AFTL associou-se positivamente com sexo masculino, maior escolaridade e maior NSE. A AFTR associou-se inversamente à idade maior que 60 anos e positivamente com o sexo masculino, maior escolaridade e não PPB. A AFDL associou-se inversamente à idade maior que 60 anos e positivamente ao sexo masculino. A AFDM associou-se inversamente com o sexo masculino, idade maior que 60 anos e não PPB; e positivamente com maior escolaridade e NSE. CONCLUSÕES: Os fatores sociodemográficos, principalmente sexo, idade e escolaridade se mostraram associados aos diferentes domínios da atividade física em adultos de etnia negra.OBJECTIVE: To analyze the prevalence and sociodemographic factors associated with different domains of physical activity

TRABALHAR PARA ESTUDAR / ESTUDAR PARA TRABALHAR: REALIDADE E POSSIBILIDADES

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Janes Siqueira

2011-07-01

Full Text Available O trabalho que apresentamos é parte da pesquisa com os estudantes das licenciaturas e da pedagogia da Universidade de Santa Cruz do Sul-UNISC-RS-Brasil. Este está inserido na linha de pesquisa: educação, trabalho e emancipação. Queremos compreender, à luz do materialismo histórico e dialético e das categorias da crítica da economia política, os significados atribuídos pelos estudantes universitários ao fenômeno trabalho e estudo. É uma pesquisa preferentemente qualitativa de natureza dialética. Para Marx, a essência da realidade humana reside no trabalho, mas a fonte de toda a riqueza está na natureza. Logo, trabalho, natureza e sociedade estão em relação dialética. Trabalho, portanto, é a ideia central articuladora, e natureza e sociedade devem ser estudadas em conexão com o trabalho. Marx trata o trabalho, no modo de produção capitalista, como impedimento ao desenvolvimento humano. Propõe o mesmo como um ato de criação e auto-expressão humana que não deve ter um valor. A compreensão dessa premissa é necessária para que os trabalhadores possam significar e ressignificar o trabalho para além da ideologia dominante. Algumas categorias aparecem como relevantes para a análise: condições de trabalho e de estudo, necessidade de formação, predominância do trabalho sobre o estudo, dificuldade de conciliar tempo de estudo e de trabalho. Na relação com o objeto de estudo, ressaltaremos a crise estrutural do capital, a desregulamentação das leis do trabalho e sua flexibilização e as contradições entre trabalho e estudo bem como quais possibilidades emancipatórias são visualizadas ou sonhadas pelos trabalhadores-estudantes. PALAVRAS-CHAVE: contradições entre trabalho e educação, condições e significados, realidade e possibilidades.

Educación para la sostenibilidad

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Educadores por la sostenibilidad

2006-04-01

Full Text Available La importancia dada por los expertos en sostenibilidad al papel de la educación queda reflejada en el lanzamiento mismo de la Década de la Educación para el Desarrollo Sostenible o, mejor, para un futuro sostenible (2005-2014 a cuyo impulso y desarrollo esta destinado este artículo, así como la página web que la Organización de Estados Iberoamericanos ha habilitado dentro de su portal digital, para la celebración de la Década.

Obtención de ferromanganeso alto carbono y escoria para el desarrollo de materiales para soldar

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Lorenzo Perdomo-González

2000-03-01

Full Text Available En el presente trabajo se realiza un análisis de la posibilidad de empleo de pirolusita en el desarrollo de aleaciones al manganeso y escorias con un sistema de óxidos MnO-SiO2-CaO con características propias para el desarrollo de fundentes para la soldadura automática para arco sumergido (SAAS. A partir de la composición química del mineral de manganeso se realizan los cálculos del proceso de reducción con el empleo de la tecnología sin fundente en presencia de coque como reductor, obteniéndose las adecuadas composiciones y las propiedades de los productos del proceso. Se realiza una corrida experimental de obtención de ferromanganeso con adiciones de dolomita, caolín y fluorita como correctores de la escoria. Se conforma una matriz de fundente para arco sumergido con la escoria y se le evalúan las propiedades tecnológicas de soldadura.

Circular polarization analyzer with polarization tunable focusing of surface plasmon polaritons

Energy Technology Data Exchange (ETDEWEB)

Wang, Sen; Zhang, Yan, E-mail: yzhang@mail.cnu.edu.cn [Department of Physics, Harbin Institute of Technology, Harbin 150001 (China); Beijing Key Laboratory for Metamaterials and Devices, and Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Department of Physics, Capital Normal University, Beijing 100048 (China); Wang, Xinke [Beijing Key Laboratory for Metamaterials and Devices, and Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Department of Physics, Capital Normal University, Beijing 100048 (China); Kan, Qiang [State Key Laboratory for Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083 (China); Qu, Shiliang [Optoelectronics Department, Harbin Institute of Technology at Weihai, Weihai 264209 (China)

2015-12-14

A practical circular polarization analyzer (CPA) that can selectively focus surface plasmon polaritons (SPPs) at two separate locations, according to the helicity of the circularly polarized light, is designed and experimentally verified in the terahertz frequency range. The CPA consists of fishbone-slit units and is designed using the simulated annealing algorithm. By differentially detecting the intensities of the two SPPs focuses, the helicity of the incident circularly polarized light can be obtained and the CPA is less vulnerable to the noise of incident light. The proposed device may also have wide potential applications in chiral SPPs photonics and the analysis of chiral molecules in biology.

Inhibition of platelet aggregation by tartrazine and a pyrazolone analogue in normal and allergic individuals.

Science.gov (United States)

Gallagher, J S; Splansky, G L; Bernstein, I L

1980-11-01

The effect of tartrazine (T) (yellow dye No. 5) and one of its metabolites an aminopyrazolone analogue (1-sulphophenyl-3-carboxy-5-hydroxypyrazole, SCHP) upon collagen-induced platelet aggregation (C-PA) was investigated in fourteen atopic patients and fourteen normal subjects. Both T and SCHP inhibited C-PA in atopic patients at significantly lower doses than in normal volunteers. The mean inhibitory concentrations of SCHP were similar to aspirin in both atopic and normal individuals. Although the precise mechanism by which these chemicals block C-PA has not been elucidated, this in vitro system may be a useful method of assessing non-immune mechanisms involved in reactions to tartrazine.

A ferromagnetic chain in a random weak field

Science.gov (United States)

Avgin, I.

1996-10-01

The harmonic magnon modes in a Heisenberg ferromagnetic chain in a random weak field are studied. The Lyapunov exponent for the uniform ( k = 0) mode is computed using the coherent potential approximation (CPA) in the weak-disorder limit. The CPA results are compared with the numerical and weak-disorder expansions of various random systems. We have found that the inverse localization length and the integrated density of states have anomalous power law behaviour as reported earlier. The CPA also reproduces the dispersion law for the same system, calculated by Pimentel and Stinchcombe using the real space renormalization scaling technique. A brief comment is also made for the uniform weak-field case.

In vivo evaluation of anticlastogenicity of extracts from medicinal plants of Miconia genus using the micronucleus test Avaliação in vivo da anticlastogenicidade de extratos de plantas medicinais do gênero Miconia através do teste do micronúcleo

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Ilce Mara S. Cólus

2008-10-01

Full Text Available The genus Miconia is comprised of approximately 1000 species. For some of them, biological activities have already been described such as the analgesic and the anti-microbial ones. The purpose of this work was to evaluate the possible protective and cytotoxic effects of the methanolic extract from M. albicans, M. cabucu, M. rubiginosa and M. stenostachya and the chloroformic extract from M. albicans in mice bone marrow cells in 540 mg/kg p.c. dose. The extracts were administered by means of forced feeding and the cyclophosphamide (CPA was applied intraperitonially one hour after supplementation with extracts. All animals were submitted to euthanasia 30 hours after the treatment. The analyzed cells were extracted from mice bone marrow according to protocol described by Schmid (1975. The cytotoxicity of the extracts was evaluated through the percentage of polychromatic erythrocytes (PCE in 200 erythrocytes (PCE + NCE. Two thousand PCEs of each animal were analyzed and the micronucleated polychromatic erythrocytes (MNPCEs frequencies were scored. The results obtained indicated that none of the extracts associated with the CPA showed cytotoxic effect and only the extracts of M. rubiginosa and M. stenostachya showed protective effect to DNA. Chemical analyses of the extracts showed that the four species studied contain mainly flavonoids, phenolic compounds and tannins. The phytochemical characterization of these extracts could contribute to elucidate the protective effect presented only by the species M. rubiginosa and M. stenostachya, besides making it possible the study of other therapeutic activities. O gênero Miconia possui aproximadamente 1000 espécies, e para algumas, já foram descritas atividades biológicas como a analgésica e antimicrobiana. Esse trabalho teve como objetivo avaliar os possíveis efeitos protetores e citotóxicos dos extratos metanólicos de M. albicans, M. cabucu, M. rubiginosa e M. stenostachya e do extrato clorof

Avaliação das competências de professores de enfermagem para desenvolver programas educativos para adultos

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Patricia Bover Draganov

2013-08-01

Full Text Available Avaliar o desempenho que o enfermeiro docente de enfermagem atribui a si, nas competências para desenvolver programas educativos para adultos, foi objetivo desse estudo descritivo, comparativo, transversal e quantitativo, desenvolvido com 226 docentes enfermeiros de cursos de graduação em enfermagem paulistanos. Os dados foram colhidos por escala de Likert, lançados em planilha Excel® e analisados por estatística descritiva e testes não paramétricos de Wilcoxon e Friedman. A população tinha predominantemente entre 46-55 anos (87/38,49%, eram mulheres (198/87, 61% e mestres (180/79, 65%. Os professores consideraram-se distantes das competências que almejavam alcançar. A menor habilidade esteve em construir desenhos de programas para atender às situações de aprendizagem e a maior, em avaliar programas de ensino. O maior desejo esteve em desenhar programas com formatos criativos e o menor desejo para usar conselhos, comitês e força-tarefa. Concluiuse que desenhar programas educativos para adultos ainda é algo pouco explorado e pouco experenciado por esses docentes.

Application of association models to mixtures containing alkanolamines

DEFF Research Database (Denmark)

Avlund, Ane Søgaard; Eriksen, Daniel Kunisch; Kontogeorgis, Georgios

2011-01-01

Two association models,the CPA and sPC-SAFT equations of state, are applied to binarymixtures containing alkanolamines and hydrocarbons or water. CPA is applied to mixtures of MEA and DEA, while sPC-SAFT is applied to MEA–n-heptane liquid–liquid equilibria and MEA–water vapor–liquid equilibria. T...

Global Comparative Public Administration: Are Graduate Programs Responding to the Call?

Science.gov (United States)

Manoharan, Aroon P.; Mirbel, Wendel; Carrizales, Tony J.

2018-01-01

Within the past two decades, globalization has led to increased literature on comparative public administration (CPA) research, and it has enhanced analyses of administrative systems in various societies. Our paper examines CPA education among Master of Public Administration and Master of Public Policy programs in the United States. The findings…

Hostility Ratings by Parents at Risk for Child Abuse: Impact of Chronic and Temporary Schema Activation

Science.gov (United States)

Farc, Maria-Magdalena; Crouch, Julie L.; Skowronski, John J.; Milner, Joel S.

2008-01-01

Objective: Two studies examined whether accessibility of hostility-related schema influenced ratings of ambiguous child pictures. Based on the social information processing model of child physical abuse (CPA), it was expected that CPA risk status would serve as a proxy for chronic accessibility of hostile schema, while priming procedures were used…

Caminhos para a gestão integrada do território no Vale do Paraíba de 1950 a 2004

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José Luiz Ronca Caruso

2004-01-01

Full Text Available The Paraíba Valley region and its political-administrative frame. The region and its two phases of Planning: the economic development and the sustainable one. The Paraíba Valley Road System as a policy of the economic planning. The Paraíba Valley Region and its physical conformation: the Paraíba do Sul river basin. The water resources management in the Paraíba do Sul river basin. Two levels of management: the federal and the one of the State. The water resources Planning and its possibilities for a sustainable development of the region, through a comprehensive management

Universidades accesibles para todos

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Roxana Stupp Kupiec

2001-01-01

Full Text Available Este trabajo pretende hacer conciencia sobrelos factores que inciden en la construcción colectiva deuniversidades dispuestas a innovar y transformar suideología, sus políticas, el currículum, los servicios estu-diantiles, la infraestructura física y administrativa y lasestrategias de comunicación e información, bajo el para-digma de la accesibilidad en el entorno. Se hace referen-cia al marco legal internacional y nacional que orientalas acciones que deben planificarse e implementarse enlas instituciones de Educación Superior.En la construcción de universidades accesibles para to-dos se requiere de un cambio en la concepción curricu-lar. Se analizan conceptos como la flexibilidad en la for-mación y el acceso a los planes de estudio para respondera las necesidades educativas de todos los estudiantes. Para promover estas transformaciones se proponen prin-cipios y prácticas tales como la interdisciplinareidad y lainclusión del tema de la discapacidad en todas las carre-ras. Además, se presentan ejemplos de aplicación en dife-rentes áreas del perfil profesional, en la formación deldocente universitario y en actividades de proyección so-cial, vida estudiantil e investigación. En el ámbito estu-diantil, se describen algunos servicios y procesos que sehan desarrollado en la Universidad de Costa Rica

Propuesta para el cálculo del Índice Dm para la validez de los ítemes

OpenAIRE

Dominguez Lara, Sergio

2013-01-01

Se presenta un programa en formato MS Excel para calcular el índice Dm para la validez de los ítemes. La validez es un proceso de acumulación de pruebas para apoyar la interpretación y el uso de las puntuaciones de los tests psicológicos, siendo las relaciones de los puntajes con otras variables externas una importante fuente de validación. Una variante es la llamada validez relacionada al criterio, en la cual se espera una correlación significativa con aquellos criterios externos que son teó...

Educación para el Ocio: Ha llegado la hora de un nuevo objetivo para una vieja idea.

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Susan Hutchinson

2012-01-01

Full Text Available La Educación para el Ocio nos sitúa ante una vieja idea, que está siendo examinada con renovado vigor en Canadá. Profesionales e investigadores de diversas disciplinas (por ejemplo, en el ámbito de Salud, la Justicia, la Educación o la Recreación reconocen, cada vez más, que son muchas las personas que pueden beneficiarse del ocio y de las oportunidades de recreación en sus comunidades, aún cuando son bastantes las no pueden hacerlo porque carecen de alfabetización en ocio. Esto es, de los conocimientos, habilidades y confianza que se necesitan para darle un significado personal, que incida positivamente en su bienestar y calidad de vida. La Educación para el Ocio es un medio clave para mejorar la alfabetización en ocio. El texto presenta un modelo de educación para el ocio desarrollado por la Dra. Brenda Robertson, argumentando cómo y por qué la Educación para el Ocio es necesaria para abordar la salud mental y el bienestar de las personas que sufren marginación en sus comunidades. Complementariamente se presentan algunas recomendaciones para avanzar esta Educación, como un componente fundamental de la agenda nacional para la recreación en Canadá.--------------------------------------------------------------------Leisure education is an old idea that is being examined with renewed vigour in Canada. Practitioners and researchers from various disciplines (e.g., health, justice, education, recreation are recognising anew that many people who could benefit from leisure or recreation opportunities in their communities are unable to do so because they lack leisure literacy. Leisure literacy refers to the knowledge, skills and confidence to engage in personally meaningful, health-enhancing leisure. Leisure education is a key means to enhance leisure literacy. The paper presents a model of leisure education developed by Dr. Brenda Robertson and argues for how and why leisure education is needed to address the mental health and well

O efeito trabalhador adicional para filhos no Brasil

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Elzira Lúcia de Oliveira

2014-06-01

Full Text Available O objetivo deste trabalho é testar a hipótese da existência do efeito trabalhador adicional para filhos no Brasil, procurando identificar se a situação de desemprego do chefe de família fará com que algum membro da família, cuja condição seja filho, transite para a População Economicamente Ativa - PEA. A base de dados utilizada foi a Pesquisa Mensal de Emprego - PME realizada pelo IBGE, que permite a construção de painéis para análise longitudinal de dados. A hipótese foi testada para pelo menos um filho com idade de 10 a 18 anos, entre 2002 e 2013, para as regiões metropolitanas de Belo Horizonte, Salvador, Porto Alegre, São Paulo, Rio de Janeiro e Recife, que compõem a área de abrangência da PME. Este trabalho admite a existência de diferencial por sexo do chefe para o efeito trabalhador adicional de filhos de 10 a 18 anos. Os resultados mostraram haver um efeito positivo maior para chefes homens do que para chefes mulheres, sendo que a variável de transição do filho para a atividade não apresentou significância estatística que permitisse assumir a existência do efeito. Corroborou-se a hipótese da existência de diferencial por sexo, contudo no sentido oposto ao da hipótese assumida.

The Acute Administration of the Selective Dopamine D3 Receptor Antagonist SB-277011A Reverses Conditioned Place Aversion Produced by Naloxone Precipitated Withdrawal From Acute Morphine Administration in Rats

Science.gov (United States)

RICE, ONARAE V.; GARDNER, ELIOT L.; HEIDBREDER, CHRISTIAN A.; ASHBY, CHARLES R.

2014-01-01

We examined the effect of SB-277011A, a selective D3 receptor antagonist, on the conditioned place aversion (CPA) response associated with naloxone-induced withdrawal from acute morphine administration in male Sprague-Dawley rats. Morphine (5.6 mg/kg i.p.) was given, followed 4 hrs later by naloxone (0.3 mg/kg i.p.) and prior to placing the animals in one specific chamber of the test apparatus. All animals were subjected to 2 of these trials. A significant CPA occurred in animals that received an i.p. injection of vehicle 30 minutes prior to the measurement of chamber preference. The pretreatment of animals (30 minutes prior to testing) with 3 mg/kg i.p. of SB-277011A did not significantly alter the CPA compared to animals treated with vehicle (1 ml/kg i.p. of deionized distilled water). In contrast, the acute pretreatment of animals with 6, 12 or 24 mg/kg i.p. of SB-277011A significantly decreased the CPA compared to vehicle-treated animals. In fact, the 12 and 24 mg/kg doses of SB-277011A significantly increased the time spent in the chamber where animals were paired with morphine and naloxone. These results suggest that the selective antagonism of D3 receptors attenuates the CPA produced by a model of naloxone-induced withdrawal from acute morphine dependence. PMID:21905128

Reappraisal of cerebellopontine angle medulloblastomas: Report of a fatal case and lessons learned

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Sachin Ranganatha Goudihalli, M.Ch. Neurosurgery

2018-06-01

Full Text Available CPA Medulloblastomas are rare in adults. We describe a case of medulloblastoma in the right CPA in a middle aged male patient who presented with short history and was preoperatively diagnosed as vestibular schwannoma. Intra-operatively it turned out to be a highly vascular and malignant lesion. Histopathology demonstrated medulloblastoma with high ki67 index. Patient was re-explored for hematoma evacuation and remained vegetative postoperatively. This is a unique case considering the older age at presentation, short duration of symptoms with atypical presentation of only 7th, 8th and lower cranial nerve involvement. MRI showed a lobulated heterogeneous extra axial right CPA mass lesion extending in the right acoustic meatus and causing mass effect and effacement of the fourth ventricle with heterogeneous enhancement post-gadolinium, suggestive of vestibular schwannoma. The aggressive behaviour of this tumor with short history has to prompt one to keep less common lesions like medulloblastomas as differential diagnosis in the CPA region. Though medulloblastomas are rare lesions in the CPA they have to be considered in the differential diagnosis based on atypical clinical behaviour, a suspicion of such diagnosis preoperatively can alter the treatment strategy, focusing on tumor embolization, safe surgical excision and adjuvant chemoradiation, aiming towards a better quality of life, in the post-operative period. Keywords: Medulloblastoma, Cerebellopontine angle, Desmoplastic

Comparison of lipid profile between degrees of severity of hepatic cirrhosis in Haji Adam Malik general hospital Medan

Science.gov (United States)

Siregar, G. A.; Tampubolon, S. E.

2018-03-01

Lipid metabolism disorders usually occurred in chronic liver disease. A cross- sectional study was conducted in liver cirrhosis (LC) patients who came to Central Hospital Haji Adam Malik, Medan on July-December 2016 to evaluatethe comparison of total cholesterol, LDL, HDL, triglyceride in Child-Pugh class. Inclusions criteria were apatient diagnosed with LC from anamnesis, physic diagnostic, laboratory, and imaging. The patientswere being evaluated with Child-Pugh (CP). P-value was calculated by using univariate and bivariate analysis of variance test (ANOVA). There were 80 subjects which included 45 men (56.3%) and 35 women (43.8%). Mean age was 51.36±12.6 years. There were 40% with HBsAg(+) and 12.5% with Anti-HCV (+). There was 60% patient with CP-C, 21.3% CP-B, and 18.8% CP-A. There were significant differences between LDL and HDL level among LC patient grade in CP-A, B, and C (p<0.05). HDL and LDL level significantly lower in CP-C compared with CP-A. There were significantly differences between LDL and HDL level among LC patient grade in CP-A, B, and C (p<0.05). HDL and LDL level significantly lower in CP-C compared with CP-A. There weren’t any statistically difference between total cholesterol and triglyceride level in LC patients with CP- A, B, and C.

Reporting and identifying child physical abuse: How well are we doing?

Science.gov (United States)

Ho, Grace W K; Bettencourt, Amie; Gross, Deborah A

2017-12-01

Entry into the child protection system in the US begins with a child maltreatment report. Some evidence suggests that report source and child age are related to report outcomes, but there has been no national study of these relationships. The purpose of this secondary data analysis was to describe the distribution of report sources for child physical abuse (CPA), and examine whether (a) the source of a report and (b) child age contribute to the likelihood of substantiation of the reported abuse. Multilevel logistic regressions were conducted using a US national sample of 204,414 children investigated for CPA in 2013 in a dataset obtained from the National Child Abuse and Neglect Data System. Results showed that fewer than one in seven children reported for CPA were confirmed victims of abuse. Professionally mandated reporters initiated the majority of CPA reports, and their reports were more likely to be substantiated compared with nonprofessionals. However, reports made by even the most accurate professional group (legal/law enforcement) had only a 26% chance of substantiation, and some professional groups had a lower likelihood of substantiation than nonprofessionals. Reports made by professionals were less likely to be substantiated as child age increased. More research is warranted to develop and test the effectiveness of training programs to improve CPA reporting and identification. © 2017 Wiley Periodicals, Inc.

Biocomercio: una alternativa para el desarrollo sostenible

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Carlos Murillo R.

2008-01-01

Full Text Available El desarrollo sostenible en países ricos en biodiversidad dependerá de la capacidad de los gobiernos de implementar los arreglos institucionales necesarios para conciliar la preservación de los recursos naturales con el uso de los mismos para la producción de bienes y servicios que puedan potenciar el crecimiento económico y un mayor bienestar para las comunidades locales donde estos recursos se encuentren. Este es el objetivo de la Iniciativa de Biocomercio que ha venido impulsando la Conferencia de Naciones Unidas para el Comercio y el Desarrollo (UNCTAD en distintos países de Latinoamérica. En el tanto estos principios y los establecidos en el CDB se puedan viabilizar e inspiren los distintos Programas Nacionales de Biocomercio en los países de la región, parecería no haber dudas de que la Iniciativa abre nuevas puertas para el uso, aprovechamiento y desarrollo sostenible de los mismos.

ANÁLISE, MODELAGEM E IMPRESSÃO 3D DE UM FRAME PARA VANTs DO TIPO QUADRÍCOPTEROS PARA VOOS EM AMBIENTE INDOOR

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Rafael Rocha Gomes

2017-01-01

Full Text Available O foco do projeto de pesquisa foi analisar, modelar e construir utilizando uma impressora 3D, um frame de um Veículo Aéreo Não Tripulado (VANT para voos em ambiente indoor. Esta aeronave será usada para experimentos laboratoriais, que exijam características especiais para ambientes indoor e de pesquisa, tais como, ser compacto, leve e uma estrutura que minimize os riscos aos operadores, pois dividirá espaço com pessoas. A motivação desta pesquisa se deu pelo fato dos frames disponíveis no mercado serem voltados para voos outdoor, como por exemplo, os utilizados para monitoramento. Com o intuito de proporcionar uma solução de aeronave para espaço laboratorial indoor, a proposta deste trabalho foi de modelar e imprimir em 3D um protótipo de frame que atenda todos os requisitos necessários para este tipo de voo.

Para una Mejor Comprensión del Desarrollo: Análisis conceptual, lógica para su abordaje e instrumentos para su medición

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Héctor Cárcamo

2006-01-01

cross nacional para la realización de estudios vinculados al desarrollo. Se plantea una revisión de conceptos fundamentales como el de desarrollo y la necesidad de la equivalencia funcional. El documento continúa con una reflexión guiada desde la noción de desarrollo social; asumiendo críticamente que el desarrollo se ha plasmado como un intento por lograr una radiografía del todo que ha olvidado la integración de sus partes constituyentes, negando de esta manera la diversidad como condición esencial para dar sentido a la idea de una visión integradora. Finalmente se realiza una revisión de CASEN como instrumento para medir el desarrollo social en Chile.

Presença do arilo na produção de mudas de Maytenus ilicifolia Presence of arils over Maytenus ilicifolia seedlings production

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Márcio Paim Mariot

2005-04-01

Full Text Available A propagação da espinheira-santa (Maytenus ilicifolia é feita por sementes, sendo indicada a retirada do arilo para a semeadura, prática que demanda muito tempo e mão-de-obra. O experimento foi instalado com o objetivo de avaliar a influência do arilo na produção de mudas de espinheira-santa. Foram utilizados dois acessos do Banco Ativo de Germoplasma de M. ilicifolia da Embrapa Clima Temperado, 30 e 91. Os tratamentos utilizados foram: T1 - sementes com arilo retirado logo após a abertura das cápsulas (armazenadas em câmara fria sem arilo; T2 - sementes com arilo retirado no dia da semeadura (armazenadas em câmara fria com arilo e T3 - sementes sem a retirada do arilo. Foram avaliados: dias da semeadura à emergência (DSE; porcentagem de emergência em canteiros (%EC; comprimento da parte aérea (CPA; diâmetro da base do caule (DBC e número de folhas/planta (NF. A presença do arilo nas sementes de M. ilicifolia não influenciou os caracteres DSE, %G, DBC e NF, podendo influenciar apenas no caráter comprimento da parte aérea, dependendo da constituição genética da população, não sendo necessária a retirada do arilo para a semeadura.Maytenus ilicifolia is propagated by seeds and it is indicated to remove arils before sowing, what requires much time and work. An experiment to evaluate the influence of arils over seedlings production was installed in Embrapa Clima Temperado, in Pelotas, RS. Two accesses (30 and 91 of M. ilicifolia Gene Bank were used. The treatments were: T1 - seeds with arils removed immediately after the capsules (fruits being opened (stored in cold room without arils; T2 - seeds with arils removed in the sowing’s day (stored in cold room with arils; T3 - seeds with arils. The characters evaluated were: days of sowing to emergence (DSE; emergence percentage (%G; aerial part length (CPA; stem base diameter (DBC and number of leaves/seedling (NF. The arils in the seeds of M. ilicifolia did not influence

GOOGLE DRIVE: POTENCIALIDADES PARA O DESIGN DE MATERIAL EDUCACIONAL DIGITAL (MED PARA ENSINO DE LÍNGUAS

Directory of Open Access Journals (Sweden)

Rosinda de Castro Guerra RAMOS

2017-07-01

Full Text Available Este trabalho tem como objetivo apresentar uma experiência sobre como o Google Drive pode ser usado para o desenho de MED (Material Educacional Digital para o ensino-aprendizagem de línguas, devido ao crescente uso das TDICs (Tecnologias Digitais de Informação e Comunicação na área de educação e aos desafios que o design de materiais educacionais para o ambiente digital nos lançam.  Para apresentar nossa experiência, faremos uma discussão teórica sobre os conceitos de desenvolvimento de material didático (TOMLINSON, 2003; RAMOS, 2009, de material educacional digital –MED – (BEHAR, 2009, multimodalidade (ROJO e BARBOSA, 2015, a lacuna existente em relação ao  letramento digital na formação de professores (LEFFA, 2013, os níveis/tipos  de interação em ambiente digital (HIRUMI, 2013 e sua relação na coconstrução de novos conhecimentos (VIGOTSKY, 1989, 1998; OLIVEIRA, 1997; BRASIL, 1998. Em seguida, descreveremos o Google Drive e as funcionalidades dos aplicativos de produtividade Google Documentos, Planilhas, Apresentações e Formulários. Finalizaremos com considerações sobre essa experiência e suas contribuições para a área de formação de professores de línguas.

Factores de riesgo para el neonato pequeño para la edad gestacional en un hospital de Lima, Perú

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J. Eduardo Tejeda-Mariaca

Full Text Available Objetivos. Identificar factores de riesgo para neonatos a término pequeños para la edad gestacional. Materiales y métodos. Cohorte retrospectiva que utilizó datos del Sistema Informático Materno Perinatal del Hospital María Auxiliadora de Lima, del período 2000 a 2010. Se evaluó la edad materna, paridad, nivel educativo, estado civil, índice de masa corporal pregestacional, número de controles prenatales, presencia de patologías como preeclampsia, eclampsia, infección urinaria y diabetes gestacional como factores de riesgo en pequeños para edad gestacional. El peso para la edad gestacional fue calculado sobre la base de percentiles peruanos. Se calcularon los riesgos relativos crudos (RR y ajustados (RRa con sus intervalos de confianza al 95% usando modelos lineales generalizados log binomial. Resultados. Se incluyeron 64 670 gestantes. La incidencia de pequeños para la edad gestacional fue 7,2%. La preeclampsia (RRa 2,0; IC 95%: 1,86-2,15, eclampsia (RRa 3,22; IC 95%: 2,38-4,35, bajo peso materno (RRa 1,38; IC 95%: 1,23-1,54, nuliparidad (RRa 1,32; IC 95%: 1,23-1,42, edad ≥35 años (RRa 1,16; IC 95%: 1,04-1,29, tener controles prenatales de 0 a 2 (RRa 1,43; IC 95%: 1,32-1,55 y 3 a 5 (RRa 1,22; IC 95%: 1,14-1,32 fueron factores de riesgo para ser pequeños para la edad gestacional. Conclusiones. Es necesario identificar a las gestantes con factores de riesgo como los encontrados para disminuir la condición de pequeños para la edad gestacional. Se debe actuar poniendo énfasis en factores modificables, tales como la frecuencia de sus controles prenatales

Ciclo Hápticos: Para Quinteto de Sopros

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Jorge Luiz de Lima Santos

2016-06-01

Full Text Available Memorial e partitura de Ciclo Hápticos, escrita em 2014 para quinteto de sopros. O memorial descreve brevemente as ferramentas metodológicas empregadas para o planejamento e criação da obra. De um lado, para produção do material melódico-harmônico foi empregado o Sistema-Gr de composição musical, desenvolvido por Carlos Almada (2014. Do outro lado, para organização formal, utilizamos o software Partitions - que faz parte do conjunto de programas do Parsemat, elaborado por Pauxy Gentil-Nunes (2009 – o qual informa o conjunto total de possibilidades de partições de um dado número.

Effects of alternative cryoprotectants, diluents, straw size and cholesterol addition on cryopreserved rooster sperm

Science.gov (United States)

Rooster sperm do not cryopreserve well. This is due in part to osmotic changes that sperm undergo during addition and removal of cryoprotectant (CPA), as well as membrane damage during the membrane phase transition from fluid at 37 degrees C to gel at low temperatures. When a CPA is removed from spe...

The Courage to Critique Policies and Practices from within: Youth Participatory Action Research as Critical Policy Analysis. A Response to ""Buscando la Libertad": Latino Youths in Search of Freedom in School"

Science.gov (United States)

Welton, Anjale

2011-01-01

This response to ""Buscando la Libertad": Latino Youths in Search of Freedom in School" by Jason G. Irizarry demonstrates how youth participatory action research (YPAR) as an instrument of subverting oppressive school policies and structures is a form of critical policy analysis (CPA). As an evolving method, CPA acknowledges the absent voices in…

Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes

DEFF Research Database (Denmark)

Andersen, Valdemar Lykke; Herth, Matthias Manfred; Lehel, Szabolcs

2013-01-01

of free amines. Aryl boronic esters containing primary, secondary, and tertiary amines were successfully converted into corresponding labeled methyl derivatives in suf¿cient radiochemical yield to apply this method for tracer development. This procedure was applied to the labeling of CIMBI-712......Cross-couplings are an alternative to conventional 11C-methylations which are generally employed in PET tracer synthesis. Therefore, we set out to develop a general procedure for the synthesis of para-11CH3 labeled aromatic amines from the corresponding para-aminoarylboronic esters in the presence...

Sistema de autenticidad para aplicaciones de análisis de eventos para seguridad.

OpenAIRE

ESCAMILLA PARDO, TONI

2017-01-01

[ES] En este proyecto se afronta la creación de un sistema distribuido capaz de garantizar, en aplicaciones empleadas para el análisis de eventos de seguridad, la autenticidad de los datos transmitidos entre el host cliente y servidor con el fin de asegurar la integridad de los mismos en la transmisión entre ambas partes, así como evitar la posible alteración en el destino. Para ello, se utilizará la tecnología blockchain a modo de base de datos en la que se almacenen los hashe...

Para uma abordagem virtuosa do Jornalismo

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Rogério Christofoletti

2012-06-01

Full Text Available As últimas décadas têm favorecido o crescimento do interesse e dos estudos sobre a ética jornalística. No Brasil e em outras praças, as abordagens deste tema têm sido na maioria das vezes por um caráter deontológico ou utilitarista. Neste artigo, chamamos a atenção para uma perspectiva que privilegie as virtudes como pontos de partida para os debates acerca das condutas dos profissionais. Uma ética das virtudes remete a Aristóteles e aos estoicos, mas vem sendo retomada por autores mais contemporâneos, como Macintyre e Comte-Sponville, entre outros. No jornalismo, esta abordagem não é definitiva ou totalizante, mas contribui para uma compreensão mais ampla da discussão, chamando inclusive a atenção para recomendações éticas úteis, práticas e atuais.

Educación para la Salud: espacio curricular optativo para los estudiantes de la carrera de Medicina

OpenAIRE

Susacasa, Sandra; Candreva, Anna; Cerasa, Silvana; Azanza, Marisa

2016-01-01

La educación para la salud adquiere relevancia en los programas institucionales internacionales. Estos se orientan a promover un mayor nivel de salud en la población. Sin embargo, las problemáticas vinculadas al campo de la educación para la salud, de acuerdo con los informes epidemiológicos, no están mejorando. Aún más, la situación se vuelve más crítica. En nuestro país las demandas sociales expresan la urgente necesidad de instalar la Educación para la Salud en espacios educativos y de sal...

Modelo para la implementación de controles internos para empresas constructoras.

OpenAIRE

Choez Chiquito, Wilton Antonio

2015-01-01

La presente investigación se refiere al tema Metodología para la implementación de nuevos métodos de Control para las empresas de construcción en el Ecuador. Donde las características principales de este sector ha sido su rápido crecimiento en las últimas dos décadas, con un alto número de trabajadores de obras con bajo o ningún nivel de educación, falta de compromiso por parte de los empleados de obra por el alto nivel de rotación que puede existir debido a que las construcciones son por per...

ELEMENTOS PARA LA CONSTRUCION DE UN PERFIL PARA EL GERENTE SOCIAL EN UN ENTORNO GLOBALIZADO

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Antonio Bastidas Unigarro

2009-07-01

Full Text Available El perfil del gerente social adecuado para enfrentar los retos del mundo globalizado se ha estructurado a partir de cuatro requerimientos fundamentales: los conocimientos, la experiencia, las habilidades y las actitudes, los cuales se analizan como competencias indispensables para administrar la problemática compleja, llena de incertidumbres y desafíos del nuevo milenio. La propuesta para la construcción de un perfil de este gerente parte de considerar tres tipos de competencias: las funcionales, las comportamentales y los requisitos de estudio y experiencia. Su construcción parte del análisis de la Gerencia Social en el estado neoliberal, escenario, que reclama la formación de gerentes sociales comprometidos en la construcción de una sociedad mas justa, incluyente, participativa, democrática y solidaria.

The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABAA Receptor Endocytosis in the vmPFC.

Science.gov (United States)

Wang, Weisheng; Ju, Yun-Yue; Zhou, Qi-Xin; Tang, Jian-Xin; Li, Meng; Zhang, Lei; Kang, Shuo; Chen, Zhong-Guo; Wang, Yu-Jun; Ji, Hui; Ding, Yu-Qiang; Xu, Lin; Liu, Jing-Gen

2017-07-26

Extinction of aversive memories has been a major concern in neuropsychiatric disorders, such as anxiety disorders and drug addiction. However, the mechanisms underlying extinction of aversive memories are not fully understood. Here, we report that extinction of conditioned place aversion (CPA) to naloxone-precipitated opiate withdrawal in male rats activates Rho GTPase Rac1 in the ventromedial prefrontal cortex (vmPFC) in a BDNF-dependent manner, which determines GABA A receptor (GABA A R) endocytosis via triggering synaptic translocation of activity-regulated cytoskeleton-associated protein (Arc) through facilitating actin polymerization. Active Rac1 is essential and sufficient for GABA A R endocytosis and CPA extinction. Knockdown of Rac1 expression within the vmPFC of rats using Rac1-shRNA suppressed GABA A R endocytosis and CPA extinction, whereas expression of a constitutively active form of Rac1 accelerated GABA A R endocytosis and CPA extinction. The crucial role of GABA A R endocytosis in the LTP induction and CPA extinction is evinced by the findings that blockade of GABA A R endocytosis by a dynamin function-blocking peptide (Myr-P4) abolishes LTP induction and CPA extinction. Thus, the present study provides first evidence that Rac1-dependent GABA A R endocytosis plays a crucial role in extinction of aversive memories and reveals the sequence of molecular events that contribute to learning experience modulation of synaptic GABA A R endocytosis. SIGNIFICANCE STATEMENT This study reveals that Rac1-dependent GABA A R endocytosis plays a crucial role in extinction of aversive memories associated with drug withdrawal and identifies Arc as a downstream effector of Rac1 regulations of synaptic plasticity as well as learning and memory, thereby suggesting therapeutic targets to promote extinction of the unwanted memories. Copyright © 2017 the authors 0270-6474/17/377096-15$15.00/0.

A1 adenosine receptor-induced phosphorylation and modulation of transglutaminase 2 activity in H9c2 cells: A role in cell survival.

Science.gov (United States)

Vyas, Falguni S; Hargreaves, Alan J; Bonner, Philip L R; Boocock, David J; Coveney, Clare; Dickenson, John M

2016-05-01

The regulation of tissue transglutaminase (TG2) activity by the GPCR family is poorly understood. In this study, we investigated the modulation of TG2 activity by the A1 adenosine receptor in cardiomyocyte-like H9c2 cells. H9c2 cells were lysed following stimulation with the A1 adenosine receptor agonist N(6)-cyclopentyladenosine (CPA). Transglutaminase activity was determined using an amine incorporating and a protein cross linking assay. TG2 phosphorylation was assessed via immunoprecipitation and Western blotting. The role of TG2 in A1 adenosine receptor-induced cytoprotection was investigated by monitoring hypoxia-induced cell death. CPA induced time and concentration-dependent increases in amine incorporating and protein crosslinking activity of TG2. CPA-induced increases in TG2 activity were attenuated by the TG2 inhibitors Z-DON and R283. Responses to CPA were blocked by PKC (Ro 31-8220), MEK1/2 (PD 98059), p38 MAPK (SB 203580) and JNK1/2 (SP 600125) inhibitors and by removal of extracellular Ca(2+). CPA triggered robust increases in the levels of TG2-associated phosphoserine and phosphothreonine, which were attenuated by PKC, MEK1/2 and JNK1/2 inhibitors. Fluorescence microscopy revealed TG2-mediated biotin-X-cadaverine incorporation into proteins and proteomic analysis identified known (Histone H4) and novel (Hexokinase 1) protein substrates for TG2. CPA pre-treatment reversed hypoxia-induced LDH release and decreases in MTT reduction. TG2 inhibitors R283 and Z-DON attenuated A1 adenosine receptor-induced cytoprotection. TG2 activity was stimulated by the A1 adenosine receptor in H9c2 cells via a multi protein kinase dependent pathway. These results suggest a role for TG2 in A1 adenosine receptor-induced cytoprotection. Copyright © 2016 Elsevier Inc. All rights reserved.

H1-histamine receptors in the amygdala are involved in emotional memory but do not mediate anxiety-related behaviors in mice submitted to EPM testing.

Science.gov (United States)

Serafim, K R; Gianlorenço, A C L; Daher, F P; Mattioli, R

2012-10-01

This study investigated the role of amygdala H(1) receptors in state-dependent memory deficits induced by l-histidine (LH). Tests using an elevated plus-maze (EPM) were performed on two consecutive days: Trial 1 (T1) and Trial 2 (T2). Before each trial, mice were intraperitoneally (IP) injected with LH (500mg/kg). Two hours later, they were microinjected with the H(1) receptor antagonist, chlorpheniramine (CPA 0.016, 0.052, or 0.16 nmol/0.1μl), or saline (SAL) into the amygdala and submitted to the EPM. LH-CPA did not affect trial 1 performances in the EPM, which indicated that these drugs did not affect anxiety. Emotional memory, as revealed by a reduction in open arm exploration between both trials, was present in the SAL-SAL groups as well as in the SAL-CPA groups for the lower doses of CPA (0.016 and 0.052nmol). On the contrary, neither the LH-SAL group nor the LH-CPA groups exhibited this decrease in open arm activity between both trials, which reveals that LH impaired emotional memory. While intra-amygdalar CPA did not interact with LH effect, it impaired per se the emotional memory performances at the highest dose (0.16nmol). No significant changes were observed in the number of enclosed arm entries (EAE), an EPM index of general exploratory activity. These results may be attributed to a combined effect in the different nucleus of the amygdala. Taken together, these results suggest that the H(1) receptors in the amygdala are not implicated in anxiety-like behaviors but are involved in emotional states induced by the T1/T2 EPM protocol in mice. Copyright © 2012 Elsevier Inc. All rights reserved.

Relationship between the Amount of Bitter Substances Adsorbed onto Lipid/Polymer Membrane and the Electric Response of Taste Sensors

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Kiyoshi Toko

2014-09-01

Full Text Available The bitterness of bitter substances can be measured by the change in the membrane electric potential caused by adsorption (CPA using a taste sensor (electronic tongue. In this study, we examined the relationship between the CPA value due to an acidic bitter substance and the amount of the bitter substance adsorbed onto lipid/polymer membranes, which contain different lipid contents, used in the taste sensor. We used iso-α-acid which is an acidic bitter substance found in several foods and beverages. The amount of adsorbed iso-α-acid, which was determined by spectroscopy, showed a maximum at the lipid concentration 0.1 wt % of the membrane, and the same phenomenon was observed for the CPA value. At the higher lipid concentration, however, the amount adsorbed decreased and then remained constant, while the CPA value decreased monotonically to zero. This constant adsorption amount was observed when the membrane potential in the reference solution did not change with increasing lipid concentration. The decrease in CPA value in spite of the constant adsorption amount is caused by a decrease in the sensitivity of the membrane as the surface charge density increases. The reason why the peaks appeared in both the CPA value and adsorption amount is based on the contradictory adsorption properties of iso-α-acid. The increasing charged lipid concentration of the membrane causes an increasing electrostatic attractive interaction between iso-α-acid and the membrane, but simultaneously causes a decreasing hydrophobic interaction that results in decreasing adsorption of iso-α-acid, which also has hydrophobic properties, onto the membrane. Estimates of the amount of adsorption suggest that iso-α-acid molecules are adsorbed onto both the surface and interior of the membrane.

Exposure to Childhood Sexual and Physical Abuse and Adjustment in Early Adulthood

Science.gov (United States)

Fergusson, David M.; Boden, Joseph M.; Horwood, L. John

2008-01-01

Objective: This research examined linkages between exposure to childhood sexual abuse (CSA) and childhood physical punishment/abuse (CPA) and mental health issues in early adulthood. Method: The investigation analyzed data from a birth cohort of over 1,000 New Zealand young adults studied to the age of 25. Results: Exposure to CSA and CPA was…

Considering Critical Turns in Research on Educational Leadership and Policy

Science.gov (United States)

Diem, Sarah; Young, Michelle D.

2015-01-01

Purpose: The purpose of this paper is to explore the use of critical policy analysis (CPA) in the fields of educational leadership and policy. In addition to exploring how CPA compares to traditional research approaches in educational leadership and policy, the authors consider the influence of long-established ways of knowing, why scholars choose…

Nuevo lenguaje para un nuevo medio

Directory of Open Access Journals (Sweden)

Inma Martín Herrera

2014-12-01

Full Text Available El concepto tradicional de comunicación unidereccional se ha roto para convertirse en comunicación pluridireccional que permitirá la retroalimentación informativa. Las nuevas formas de redactar, contar diseñar y presentar la información en Internet exige nuevos hábitos de lectura por parte de la audiencia. El lector deberá tomar conciencia de que está frente a un medio diferente con el que debe familiarizarse para hacer uso correcto del soporte digital, se informará adecuadamente para disfrutar de las ventajas del innovador medio, conocido como Periodismo de servicios o Nuevo Periodismo.

Ionic double layer of atomically flat gold formed on mica templates

International Nuclear Information System (INIS)

Chilcott, Terry C.; Wong, Elicia L.S.; Coster, Hans G.L.; Coster, Adelle C.F.; James, Michael

2009-01-01

Electrical impedance spectroscopy characterisations of gold surfaces formed on mica templates in contact with potassium chloride electrolytes were performed at the electric potential of zero charge over a frequency range of 6 x 10 -3 to 100 x 10 3 Hz. They revealed constant-phase-angle (CPA) behaviour with a frequency exponent value of 0.96 for surfaces that were also characterised as atomically flat using atomic force microscopy (AFM). As the frequency exponent value was only marginally less than unity, the CPA behaviour yielded a realistic estimate for the capacitance of the ionic double layer. The retention of the CPA behaviour was attributed to specific adsorption of chloride ions which was detected as an adsorption conductance element in parallel with the CPA impedance element. Significant variations in the ionic double layer capacitance as well as the adsorption conductance were observed for electrolyte concentrations ranging from 33 μM to 100 mM, but neither of these variations correlated with concentration. This is consistent with the electrical properties of the interface deriving principally from the inner or Stern region of the double layer.

Pairing and recombination features during meiosis in Cebus paraguayanus (Primates: Platyrrhini

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Garcia-Cruz Raquel

2009-06-01

Full Text Available Abstract Background Among neotropical Primates, the Cai monkey Cebus paraguayanus (CPA presents long, conserved chromosome syntenies with the human karyotype (HSA as well as numerous C+ blocks in different chromosome pairs. In this study, immunofluorescence (IF against two proteins of the Synaptonemal Complex (SC, namely REC8 and SYCP1, two recombination protein markers (RPA and MLH1, and one protein involved in the pachytene checkpoint machinery (BRCA1 was performed in CPA spermatocytes in order to analyze chromosome meiotic behavior in detail. Results Although in the vast majority of pachytene cells all autosomes were paired and synapsed, in a small number of nuclei the heterochromatic C-positive terminal region of bivalent 11 remained unpaired. The analysis of 75 CPA cells at pachytene revealed a mean of 43.22 MLH1 foci per nucleus and 1.07 MLH1 foci in each CPA bivalent 11, always positioned in the region homologous to HSA chromosome 21. Conclusion Our results suggest that C blocks undergo delayed pairing and synapsis, although they do not interfere with the general progress of pairing and synapsis.

Limitations of the Conventional Phase Advance Method for Constant Power Operation of the Brushless DC Motor

International Nuclear Information System (INIS)

Lawler, J.S.

2001-01-01

The brushless dc motor (BDCM) has high-power density and efficiency relative to other motor types. These properties make the BDCM well suited for applications in electric vehicles provided a method can be developed for driving the motor over the 4 to 6:1 constant power speed range (CPSR) required by such applications. The present state of the art for constant power operation of the BDCM is conventional phase advance (CPA)[1]. In this paper, we identify key limitations of CPA. It is shown that the CPA has effective control over the developed power but that the current magnitude is relatively insensitive to power output and is inversely proportional to motor inductance. If the motor inductance is low, then the rms current at rated power and high speed may be several times larger than the current rating. The inductance required to maintain rms current within rating is derived analytically and is found to be large relative to that of BDCM designs using high-strength rare earth magnets. Th us, the CPA requires a BDCM with a large equivalent inductance

Early-life adversity-induced long-term epigenetic programming associated with early onset of chronic physical aggression: Studies in humans and animals.

Science.gov (United States)

Chistiakov, Dimitry A; Chekhonin, Vladimir P

2017-06-05

To examine whether chronic physical aggression (CPA) in adulthood can be epigenetically programmed early in life due to exposure to early-life adversity. Literature search of public databases such as PubMed/MEDLINE and Scopus. Children/adolescents susceptible for CPA and exposed to early-life abuse fail to efficiently cope with stress that in turn results in the development of CPA later in life. This phenomenon was observed in humans and animal models of aggression. The susceptibility to aggression is a complex trait that is regulated by the interaction between environmental and genetic factors. Epigenetic mechanisms mediate this interaction. Subjects exposed to stress early in life exhibited long-term epigenetic programming that can influence their behaviour in adulthood. This programming affects expression of many genes not only in the brain but also in other systems such as neuroendocrine and immune. The propensity to adult CPA behaviour in subjects experienced to early-life adversity is mediated by epigenetic programming that involves long-term systemic epigenetic alterations in a whole genome.

Molecular mechanism of mast cell–mediated innate defense against endothelin and snake venom sarafotoxin

Science.gov (United States)

Schneider, Lars A.; Schlenner, Susan M.; Feyerabend, Thorsten B.; Wunderlin, Markus; Rodewald, Hans-Reimer

2007-01-01

Mast cells are protective against snake venom sarafotoxins that belong to the endothelin (ET) peptide family. The molecular mechanism underlying this recently recognized innate defense pathway is unknown, but secretory granule proteases have been invoked. To specifically disrupt a single protease function without affecting expression of other proteases, we have generated a mouse mutant selectively lacking mast cell carboxypeptidase A (Mc-cpa) activity. Using this mutant, we have now identified Mc-cpa as the essential protective mast cell enzyme. Mass spectrometry of peptide substrates after cleavage by normal or mutant mast cells showed that removal of a single amino acid, the C-terminal tryptophan, from ET and sarafotoxin by Mc-cpa is the principle molecular mechanism underlying this very rapid mast cell response. Mast cell proteases can also cleave ET and sarafotoxin internally, but such “nicking” is not protective because intramolecular disulfide bridges maintain peptide function. We conclude that mast cells attack ET and sarafotoxin exactly at the structure required for toxicity, and hence sarafotoxins could not “evade” Mc-cpa's substrate specificity without loss of toxicity. PMID:17923505

“Libros para niñas y libros para niños”: Presencia de estereotipos de género en una colección de libros para dibujar

Directory of Open Access Journals (Sweden)

Yolanda Cabrera García-Ochoa

2014-06-01

Full Text Available Los aprendizajes que se producen a partir de las propuestas imaginarias y simbólicas en los materiales didácticos pueden contener elementos sexistas. El objetivo del estudio consiste en determinar, a través de un análisis de contenido, si la colección de libros para dibujar “Doodle para niñas” y “Doodle para niños” representa roles estereotipados de género en sus imágenes y en el texto escrito. Tanto a nivel de representación gráfica como escrita, ambos libros utilizan roles estereotipados sobre todo en detrimento de la mujer. Aunque el sistema educativo español señala hace años un modelo igualitario para eliminar la discriminación, los avances conseguidos desde un prisma constitucional y legal, van muy por delante de unos sistemas culturales y sociales que apenas han evolucionado.

Plan de mercadeo para una promotora de eventos corporativos

OpenAIRE

Burbano Zhindon, Andrea Cristina; Chavez Lopez, Maria Cecilia; Orlando Haro, Sofia Pierina; Miranda, Jorge Luis

2009-01-01

Este proyecto presenta una alternativa para todas aquellas empresas que realizan eventos frecuentemente, ofreciéndoles un servicio personalizado para la coordinación de cada uno de los detalles que conlleva la organización de un evento. El objetivo fundamental de este estudio es desarrollar un plan de mercadeo para el servicio antes mencionado, aplicando los principios del marketing para su correcta implementación.

Agricultura familiar para el desarrollo rural incluyente

Directory of Open Access Journals (Sweden)

Laksmi Reddiar Krishnamurthy

2017-04-01

Full Text Available Las comunidades indígenas Mayas de la península de Yucatán han practicado la antigua tradición de agricultura familiar, en particular los huertos caseros, para garantizar su seguridad alimentaria. Con el objetivo de mejorar la práctica tradicional considerando paradigmas de la ciencia moderna, por una parte, se colectaron datos para definir la complejidad estructural y diversidad funcional a partir de 20 huertos familiares en cinco comunidades: X - Maben, X - Pichil, X - Yatil, San José II y Melchor Ocampo; y por otra, se organizaron grupos de discusión para dilucidar la estrategia de gestión practicada por las comunidades nativas. Los resultados mostraron que los huertos son manejados principalmente por las mujeres. También mostraron que el propósito principal del crecimiento y mantenimiento de los huertos familiares es garantizar la producción de alimentos nutritivos durante todo el año. Y, por último que los huertos caseros también sirven para propósitos secundarios tales como la provisión de productos y servicios para la medicina tradicional. El estudio sugiere que se debe de promover e invertir en huertos caseros para mejorar las estrategias de desarrollo incluyente en ambientes socio-culturales y biofísicos similares.

Patrones de diseño para mejorar la accesibilidad y uso de aplicaciones sociales para adultos mayores

Directory of Open Access Journals (Sweden)

Huizilopoztli Luna García

2015-07-01

Full Text Available El objetivo de este artículo fue proponer una colección no exhaustiva de 36 patrones para el diseño de interacciones en aplicaciones sociales para adultos mayores. La propuesta representa un punto de partida confiable para facilitar, a diseñadores/desarrolladores, la integración de usabilidad en las interfaces de estas tecnologías con el fin de fomentar su aceptación, uso y adopción entre los adultos mayores. Esta propuesta se basa en esfuerzos previos comúnmente expresados como criterios y guías de diseño para definir los posibles problemas de usabilidad en este tipo de interfaces, y se concentra en reforzar estos enfoques mediante la integración de una mayor descripción de tales anomalías y alternativas de solución bajo una estructura de patrones útil para los diseñadores/desarrolladores. Se realizó un estudio de usabilidad con la técnica «evaluación heurística» (comúnmente utilizada en interacción hombre-máquina para obtener la percepción de los usuarios sobre un diseño particular. El trabajo se llevó a cabo desde dos perspectivas: el punto de vista de expertos técnicos y la percepción de un grupo social de adultos mayores. Los resultados reflejaron que los patrones propuestos propician la creación de interfaces bien diseñadas capaces de ofrecer una mejor experiencia de uso y promueven un impacto positivo en la calidad de vida de los adultos mayores.

Alimentos balanceados para perros en Costa Rica

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Ruth Vargas

2001-01-01

Full Text Available Diagnóstico de la comercialización de alimentos balanceados para perros en Costa Rica. Para ampliar los reportes oficiales de la comercialización de alimentos para perros se creó una base de datos que incluyó cantidad, costo, empaque y formulación durante el período 1998 a agosto del 2000. De 1995 a 1998 y de 1996 a 1999 la producción nacional incrementó un 90,4% y la importación un 42,56% respectivamente, ocupando los alimentos nacionales un 72% del tonelaje y un 70% del valor en dólares americanos. No fue posible determinar cuál es el empaque más comercializado, pero si que los alimentos extrusados son los que ocupan el primer lugar y que los alimentos recomendados para cachorros y adultos son los que más se comercializan. La ausencia de datos en las declaraciones sugiere la necesidad de incrementar el control en las mismas en caso de requerirse un estudio de mercado, ya que contrariamente a esta situación el mayor número de garantías inscritas corresponden separadamente para las fases de cachorros y adultos. Merece también atención que las garantías indican mayores porcentajes de proteína cruda que los recomendados por la AAFCO y que al menos 36 fórmulas son recomendadas para estados sanitarios específicos (p.e. para perros con problemas de alergias, cálculos renales, pérdidas de pelo, etc. sin que oficialmente se encuentre registrada ninguna fórmula medicada

Exposure to Childhood Sexual and Physical Abuse and Subsequent Educational Achievement Outcomes

Science.gov (United States)

Boden, Joseph M.; Horwood, L. John; Fergusson, David M.

2007-01-01

Objective: This paper examined the relationship between exposure to sexual and physical abuse (CSA and CPA) in childhood and later educational achievement outcomes in late adolescence and early adulthood in a birth cohort of over 1,000 children studied to age 25. Method: Retrospective data on CSA and CPA were gathered at ages 18 and 21 and used to…

Slow return of displaced Southern Sudanese

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Tim Morris

2007-07-01

Full Text Available The pace of repatriation of Sudanese refugees and return of IDP s to South Sudan has picked up but expectations at the time of the signing of the Comprehensive Peace Agreement (CPA CPA in January 2005 have yet to be realised. With all eyes on Darfur, assistance to sustain returns to South Sudan remains inadequate.

The involvement of CRF1 receptor within the basolateral amygdala and dentate gyrus in the naloxone-induced conditioned place aversion in morphine-dependent mice.

Science.gov (United States)

Valero, E; Gómez-Milanés, I; Almela, P; Ribeiro Do Couto, B; Laorden, M L; Milanés, M V; Núñez, C

2018-06-08

Drug withdrawal-associated aversive memories trigger relapse to drug-seeking behavior. Corticotrophin-releasing factor (CRF) is an important mediator of the reinforcing properties of drugs of abuse. However, the involvement of CRF1 receptor (CRF1R) in aversive memory induced by opiate withdrawal has yet to be elucidated. We used the conditioned-place aversion (CPA) paradigm to evaluate the role of CRF1R on opiate withdrawal memory acquisition, along with plasticity-related processes that occur after CPA within the basolateral amygdala (BLA) and dentate gyrus (DG). Male mice were rendered dependent on morphine and injected acutely with naloxone before paired to confinement in a naloxone-associated compartment. The CPA scores as well as the number of TH-positive neurons (in the NTS-A2 noradrenergic cell group), and the expression of the transcription factors Arc and pCREB (in the BLA and DG) were measured with and without CRF1R blockade. Mice subjected to conditioned naloxone-induced morphine withdrawal robustly expressed CPA. Pre-treatment with the selective CRF1R antagonist CP-154,526 before naloxone conditioning session impaired morphine withdrawal-induced aversive memory acquisition. CP-154,526 also antagonized the enhanced number of TH-positive neurons in the NTS-A2 that was seen after CPA. Increased Arc expression and Arc-pCREB co-localization were seen in the BLA after CPA, which was not modified by CP-154,526. In the DG, CPA was accompanied by a decrease of Arc expression and no changes in Arc-pCREB co-localization, whereas pre-treatment with CP-154,526 induced an increase in both parameters. These results indicate that CRF-CRF1R pathway could be a critical factor governing opiate withdrawal memory storage and retrieval and might suggest a role for TH-NA pathway in the effects of withdrawal on memory. Our results might indicate that the blockade of CRF1R could represent a promising pharmacological treatment strategy approach for the attenuation of the relapse

Actitud Positiva: la base para la competitividad

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Marco Anderson Espinoza

2008-04-01

Full Text Available Una estrategia empresarial enfocado en el mejoramiento continuo de la productividad para la competitividad, depende significativamente del manejo inteligente de tres variables visibles:Calidad, Entrega oportuna y Costo. No obstante, estas tres variables no suelen sersuficientes. La estrategia debe ser complementada con el manejo adecuado de variables intangibles como la Motivación y las Condiciones de Trabajo, con la aplicación de Tecnología Ambientalmente Amigable, en un marco de Actitud Positiva.A final de cuentas, la Actitud Positiva es fundamental para el recurso humano de cualquier organización, a fin de construir una plataforma sólida y estable que sirva de base para soportar un proceso sostenible de mejoramiento de la productividad, para aumentar la competitividad como estrategia empresarial exitosa.

Technological properties of kaolin from Para; Propriedades tecnologicas do caulin do Para

Energy Technology Data Exchange (ETDEWEB)

Hildebrando, E.; Martin-Cortes, G.R.; Esper, F.J.; Wiebeck, H.; Alves Junior, P.; Valenzuela-Diaz, F.R., E-mail: germac@usp.br [Universidade de Sao Paulo (PMT/EP/USP), Sao Paulo, SP (Brazil). Escola Politecnica. Departamento de Engenharia Metalurgica e de Materiais

2011-07-01

The NE of the State of Para, is notable for its large reserves of kaolin for paper. Kaolin is a mineral composed of hydrated aluminum silicates such as kaolinite and halloysite. The exploitation of these reserves to generate products with higher commercial value, especially in the industries of adsorbents and catalysts, is what motivates the continuous study of technological properties of the Amazon kaolin's. Thus, this paper presents a technological characterization of a sample of kaolin from Para State by X-ray diffraction, SEM - scanning electron microscopy and infrared spectroscopy. The results of preliminary tests indicate that the sample consists for the most part by kaolinite present in low concentrations of quartz and anatase. (author)

Desarrollo de manuales para la inspección y revisión de instalaciones petrolíferas para uso propio, para suministro a vehículos y transporte de mercancías peligrosas por carretera

OpenAIRE

Cardell Bilbao, Pablo Juan

2010-01-01

El objetivo de este proyecto es la realización de un manual que aúne y clarifique toda la documentación, la normativa y los procedimientos necesarios para cumplir las auditorías (revisiones e inspecciones) en las instalaciones existentes, los trámites para la apertura de nuevas instalaciones para suministro a vehículos (especialmente las Estaciones de Servicio (EESS), y para Usos Propios (UUPP) en Canarias, y el transporte de mercancías peligrosas por carretera (ADR), mostrando el procedimien...

Oxitocina: nuevas perspectivas para una droga antigua

OpenAIRE

Steven L. CLARK; Kathleen Rice SIMPSON; G. Eric KNOX; Thomas J. GARITE

2010-01-01

La oxitocina es el medicamento más comúnmente asociada con la prevención de complicaciones perinatales y recientemente fue incluida por el Instituto para la Administración Medicamentosa Segura (Institute for Safe Medication Practices - ISMP) en una pequeña lista de medicamentos “con alto grado de riesgos”, lo que puede “necesitar salvaguardas especiales para reducir el riesgo de error”. Las recomendaciones actuales para administrar este medicamento son vagas en relación a la indicación, tiemp...

INICIATIVAS PARA EL CAMBIO

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César Alfonso Defrancisco-Larrañaga

2013-07-01

Full Text Available El planeta no atraviesa por su mejor momento en materia de conservación y renovación de sus recursos naturales. Claramente en los últimos tiempos los recursos hídricos han venido haciéndose cada vez menores; el hombre ha notado con preocupación y vivido en carne propia este fenómeno, que de no ser tratado a tiempo, podría atentar contra la existencia misma. Esto lo ha alentado a buscar métodos que sirvan como solución para contrarrestar éste mal y crear conciencia entre sus iguales, para así poder garantizar su permanencia y la de su entorno durante muchas generaciones. En países desarrollados del continente europeo y en algunos lugares de América del norte, el uso de sistemas de reutilización y tratamiento de aguas grises y aprovechamiento de las aguas lluvias se ha convertido en una constante y nos están dando las pautas para poder seguir el ejemplo y así de esta manera poder aportar a la causa ambiental y a su vez crear un ahorro en nuestros gastos mensuales de consumo.

AUTONOMÍA PARA APRENDER Y AUTONOMÍA PARA VIVIR

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Miryam Narváez Rivero

2005-04-01

Full Text Available RESUMEN: El sistema educativo tiene el reto actual de formar individuos autónomos. Esta autonomía no implica solo el que las personas tengan los recursos necesarios para aprender a aprender, sino que puedan convivir armónicamente en comunidad, escuchándose a sí mismos para tomar sus propias decisiones, sin estar determinados por deseos instintivos ni modelos coercitivos impuestos por la sociedad. Así, para desarrollar autonomía, le corresponde a la educación trabajar tres elementos: la voluntad, la libertad y la autoestima. De esta forma, una educación promotora de una verdadera autonomía deberá tener un carácter dialógico, haciendo hincapié en la integración solidaria de la persona con su comunidad. Nos referimos a una persona que no ha renunciado a sus metas ni aspiraciones, sino que sabe cómo guiarlas hacia un proyecto común de bienestar general. ABSTRACT: The educative system’s latest challenge is to educate independent individuals. This autonomy does not just imply that people have the necessary resources to learn to learn, but the ones they need to live together in harmony with others, listening to themselves to make their own decisions without being determined by instinctive desires nor coercive models imposed by the society. It is so, that to develop autonomy, the educational system must work with these three elements: will, freedom and self-esteem. Also, an educational system which promotes a true autonomy must have a dialogic character, insisting on the individual solidarity integration with the community; with this, we mean a person who has not resigned to his goals or aspirations, but that knows how to guide them towards a common project for the community well-being.

Knowledge and awareness of the Consumer Protection Act among dental professionals in India: A systematic review.

Science.gov (United States)

Singh, Gurminder; Gambhir, Ramandeep Singh; Singh, Simarpreet; Talwar, Puneet Singh; Munjal, Vaibhav

2014-07-01

The medical profession has been included in the Consumer Protection Act (CPA), to protect the interests of the patients in case of any unethical treatment rendered by the doctor. The present systematic review was conducted to assess the knowledge and awareness of CPA among dental professionals in India. A systematic review of relevant cross-sectional observational studies was conducted regarding the level of knowledge and awareness of CPA among dental professionals in India. Five studies out of 44 were finally included in the present review, after conducting both an electronic and manual search of scientific databases. The potential biases were reported and appropriate data was extracted by the concerned investigators. More than 90% of the study subjects in one of the studies were aware of the CPA, as compared to other studies. In two studies, when queried about the correct time period during which a patient can sue a doctor, very few subjects (18 and 23.2%) answered correctly. Almost 90% of the subjects were taking some form of consent in one of the studies. Private practitioners had more awareness as compared to academicians and combined practitioners. The results of the present review showed that a majority of the subjects were aware of the existence of CPA, but knowledge about the basic rules and regulations was lacking in a few studies. Therefore, dental professionals need to keep themselves updated on the various rules and latest amendments to save themselves from any litigation.

Reservoir simulation with the cubic plus (cross-) association equation of state for water, CO2, hydrocarbons, and tracers

Science.gov (United States)

Moortgat, Joachim

2018-04-01

This work presents an efficient reservoir simulation framework for multicomponent, multiphase, compressible flow, based on the cubic-plus-association (CPA) equation of state (EOS). CPA is an accurate EOS for mixtures that contain non-polar hydrocarbons, self-associating polar water, and cross-associating molecules like methane, ethane, unsaturated hydrocarbons, CO2, and H2S. While CPA is accurate, its mathematical formulation is highly non-linear, resulting in excessive computational costs that have made the EOS unfeasible for large scale reservoir simulations. This work presents algorithms that overcome these bottlenecks and achieve an efficiency comparable to the much simpler cubic EOS approach. The main applications that require such accurate phase behavior modeling are 1) the study of methane leakage from high-pressure production wells and its potential impact on groundwater resources, 2) modeling of geological CO2 sequestration in brine aquifers when one is interested in more than the CO2 and H2O components, e.g. methane, other light hydrocarbons, and various tracers, and 3) enhanced oil recovery by CO2 injection in reservoirs that have previously been waterflooded or contain connate water. We present numerical examples of all those scenarios, extensive validation of the CPA EOS with experimental data, and analyses of the efficiency of our proposed numerical schemes. The accuracy, efficiency, and robustness of the presented phase split computations pave the way to more widespread adoption of CPA in reservoir simulators.

Zinc Transport Differs in Rat Spermatogenic Cell Types and Is Affected by Treatment with Cyclophosphamide1

Science.gov (United States)

Downey, Anne Marie; Hales, Barbara F.; Robaire, Bernard

2016-01-01

Adequate zinc levels are required for proper cellular functions and for male germ cell development. Zinc transport is accomplished by two families of zinc transporters, the ZIPs and the ZnTs, that increase and decrease cytosolic zinc levels, respectively. However, very little is known about zinc transport in the testis. Furthermore, whether cytotoxic agents such as cyclophosphamide (CPA), a known male germ cell toxicant, can affect zinc transport and homeostasis is unknown. We examined zinc transporter expression and zinc transport in pachytene spermatocytes (PS) and round spermatids (RS) in a normal state and after exposure to CPA. We observed differences in the expression of members of the ZnT and ZIP families in purified populations of PS and RS. We also observed that RS accumulate more zinc over time than PS. The expression of many zinc binding genes was altered after CPA treatment. Interestingly, we found that the expression levels of ZIP5 and ZIP14 were increased in PS from animals treated daily with 6 mg/kg CPA for 4 wk but not in RS. This up-regulation led to an increase in zinc uptake in PS but not in RS from treated animals compared to controls. These data suggest that CPA treatment may alter zinc homeostasis in male germ cells leading to an increased need for zinc. Altered zinc homeostasis may disrupt proper germ cell development and contribute to infertility and effects on progeny. PMID:27281708

Significado de la calidad de vida del adulto mayor para sí mismo y para su familia

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Martha Vera

2007-09-01

Full Text Available Objetivo: Comprender el significado que la expresión lingüística ‘calidad de vida del adulto mayor’ tiene para el adulto mayor y para su familia. Diseño: Estudio cualitativo, descriptivo, interpretativo - comprensivo, fundamentado en la Teoría de las Representaciones Sociales. Lugar: Asentamiento Humano Laura Caller, en Los Olivos. Participantes: Adultos mayores y sus respectivos grupos familiares. Métodos: Las técnicas e instrumentos utilizados fueron la observación, entrevista a profundidad y grupos focales; guía de observación y dos cuestionarios con ocho preguntas norteadoras, previamente validados. Principales medidas de resultados: Significado de calidad de vida para el adulto mayor y para la familia. Resultados: Participaron dieciséis adultos mayores con sus respectivos grupos familiares, entre 2004 y 2006. Los discursos a través de la ‘objetivación’ y el ‘anclaje’ y los análisis general, ideográfico-axial y nomotético-selectivo permitieron la emergencia de cuatro representaciones sociales: a conocimiento sobre la vejez y ser un adulto mayor; b elementos principales y secundarios del significado de calidad de vida del adulto mayor; c valores y actitudes del adulto mayor y familia sobre la calidad de vida; y, d necesidades del adulto mayor como ser social y la calidad de vida. Conclusiones: Para el adulto mayor, calidad de vida significa tener paz y tranquilidad, ser cuidado y protegido por la familia con dignidad, amor y respeto, y tener satisfechas como ser social sus necesidades de libre expresión, decisión, comunicación e información. Para la familia, que el adulto mayor satisfaga sus necesidades de alimentación, vestido, higiene y vivienda.

ÉTICA PARA O DESENVOLVIMENTO SUSTENTÁVEL – UMA RESPONSABILIDADE PARA COM AS GERAÇÕES FUTURAS

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Patrícia Melo Silva

2011-02-01

Full Text Available O trabalho apresenta uma discussão sobre como a ética pode contribuir para a ciência se desenvolver de maneira sustentável com o intuito de garantir a biodiversidade em uma sociedade que cresce de acordo com a moral utilitarista. Os principais aspectos analisados foram questões da ética como proposta oposta à moral utilitarista, além de aspectos relacionados à economia global, ao sistema capitalista e à interdisciplinaridade. O principal objetivo do trabalho é analisar como a ética pode contribuir para o desenvolvimento sustentável e para o respeito à biodiversidade. A metodologia utilizada foi a de análise bibliográfica.

Nueva Sede para la Academia

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Mario Camacho Pinto

1994-06-01

Full Text Available

Una nueva sede adecuadamente dotada siempre estuvo en la mente de nuestros expresidentes Académicos César Augusto Pantoja, Hernando Groot, Pablo Gómez Martínez, Jorge Cavelier Gaviria y Efraim Otero-Ruiz, con quienes me tocó en suerte trabajar 12 años consecutivos, cerca de ellos a través de mi cargo de Coordinardor de la Comisión Permanente de Biblioteca y Publicaciones y de la Revista MEDICINA que se ha venido publicando sin interrupciones dentro de un compañerismo ejemplar; además de otras distinciones operativas que me inducen a expresar gratitud.

Ahora, además, como Secretario de la Coporación por elección unánime de la Asamblea hace dos años, he sido testigo ático de una intensa, inteligente e inagotable actividad que nuestro Presidente Académico Juan Jacobo Muñoz Delgado quien siempre con el visto bueno de la Junta Directiva, mediante un acelerado ritmo de trabajo se impuso la tarea de convertir en realidad inmediata tan anhelada y necesaria idea.

En efecto, la nueva sede fue inaugurada oficialmente el día 2 de septiembre de 1993.

Este Editorial es la constancia escrita de tal febril actividad que para proporcionar evidencia a los lectores de “MEDICINA” resumo en breves incisos que muestran el tránsito a un estado con superávit de excepción para esta clase de instituciones:

1. Terminación de la obra ya iniciada de la remodelación arquitectónica, tanto exterior de seguridad y aspecto como interior con suficientes y modernas instalaciones.

2. Cerramiento total con altas y elegantes rejas metálicas y doble portería por la calle 69 y la carrera 7a.

3. Aparcadero lujosamente adoquinado, amplio y seguro para 30 automóviles.

4. Decoración interior estéticamente consultada, bien lograda en cortinas y clásicas lámparas de cristal obsequiadas por conocidos académicos. Un par de originales urnas precolombianas en el hall de entrada.

5. Zona social doble, amplia

Hacia un nuevo diseño para el aprendizaje: escenarios educativos para la Web 2.0

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Alejandro Canales Cruz

2014-10-01

Full Text Available En este artículo se retoma la caracterización de pedagogía en la virtualidad, la cual se fundamenta en la apropiación tecnológica en función de la educación y voluntad de los participantes. Se propone la convergencia del diseño tecnopedagógico, unido a la apropiación creativa y a los usos pedagógicos efectivos para maximizar el proceso educativo. Se plantea el empleo de la especificación IMS Learning Design (LD para la construcción de escenarios educativos como un proceso sistémico con actividades interrelacionadas que permiten crear ambientes que en verdad faciliten, de forma mediada, el proceso educativo. Finalmente, se presenta una herramienta para la autoría de escenarios educativos.

Modelo de negocio para bebidas funcionales Ceiba

OpenAIRE

Gil Giraldo, Jhonatan; Restrepo Mesa, Juan Eduardo

2017-01-01

El presente documento, modelo de negocio para bebidas naturales Ceiba, es el trabajo de grado realizado por los autores con el fin de optar al título de magíster en Administración (MBA) de la Universidad EAFIT -- El cual esta soportado en los diferentes conceptos y metodologías de modelo de negocio y planes de negocio -- Por tratarse de un prototipo que busca definir los elementos estratégicos necesarios para su desarrollo, arrojó como resultado que la metodología más adecuada para ser aplica...

Middleware Cerberus usando RFID para rastreabilidade bovina

OpenAIRE

Silva, Márcio Roberto

2009-01-01

A gerência na zootecnia de precisão é cada vez mais necessária para garantia de lucros e a conquista de novos mercados os quais exigem qualidade e certificação. Nesta dissertação é abordado um sistema de rastreabilidade para o controle na bovinocultura utilizando chips RFID. Sendo que a identificação segura dos animais é a base para a rastreabilidade bovina e bubalina. Em vista as exigências do mercado consumidor o governo brasileiro instituiu o Sistema Brasileiro de Identificação e Certifica...

Test para la profilaxis de la prematuridad

OpenAIRE

Cruz Laguna, Gladys María

2008-01-01

La prematuridad constituye un problema mundial de salud, la comunidad científica busca predictores para disminuir su incidencia. La investigación persiguió obtener una escala de puntuación que modele las características cervicales y permita diagnosticar la condición de riesgo de las gestantes para extender el período de gestación y lograr nacimientos al término. Se realizó un cuasiexperimento en gestantes con factores de riesgo para la prematuridad del municipio Holguín. La muestra fue confor...

para mujeres y niños vulnerables

International Development Research Centre (IDRC) Digital Library (Canada)

... a nivel global . 73. Generar confianza y crear espacio para el compromiso . 75 .... para construir sistemas de salud sólidos y han colaborado inmensamente con ..... instituciones sanitarias se ve obligado a recolectar información y a registrar ...

Modelo para la Gestión de la Innovación por Proyectos para Empresas que aplican el Perfeccionamiento Empresarial en Cuba

OpenAIRE

Antonio M. Navarro López

2008-01-01

Las Empresas que aplican el Perfeccionamiento Empresarial, no cuentan con un Modelo para la Gestión de la Innovación para el desarrollo Empresarial. Por lo que se propone éste Modelo para las mismas y generalizándose de esta forma el conocimiento de Gestión de la Innovación de la Empresa de Proyectos de Arquitectura e Ingeniería de Matanzas, Cuba, lo que permite el desarrollo Empresarial y la Implantación del Sub Sistema de Innovación para estas Empresas en Perfeccionamiento Empresarial. Se p...

Retos para la agricultura en Costa Rica

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Oscar Arias M.

2005-01-01

Full Text Available Retos para la agricultura en Costa Rica es un análisis crítico del desarrollo agrícola de Costa Rica de los últimos 25 años. La diversificación agrícola que promovió Costa Rica en la década de los ochenta, permitió ampliar la oferta exportable y reducir la vulnerabilidad de la dependencia económica de productos tradicionales, como café y banano. Los retos de la economía global y el establecimiento de tratados comerciales con muchos países, hacen necesario que el país promueva en el sector agrícola la exportación con mayor valor agregado, para lo cual es necesario una modernización y reconversión productiva, ya que el modelo actual está agotado. Debemos mejorar sustancialmente los bienes y servicios que ofrecemos; para este propósito, algunos aspectos como la imagen de marca del país con tradición democrática, respeto a los derechos laborales, así como las buenas prácticas de manejo ambiental, deben publicitarse. Como una herramienta clave para la incorporación de mayor valor agregado a nuestra producción agrícola, debemos promover la inversión en investigación y desarrollo, que históricamente ha sido escasa (0,4% del PIB. En vista de que el Estado Costarricense ha demostrado una incapacidad crónica para impulsar la ciencia y la tecnología como una herramienta para nuestro desarrollo, se propone un estímulo a la inversión privada y el fortalecimiento de una alianza con el Estado y las universidades. Se analiza la conveniencia del fortalecimiento de la autosuficiencia alimentaria y de que las empresas pequeñas y medianas jueguen un papel más activo en la agro-exportación. Respecto a los tratados comerciales que se han venido negociando, se considera la conveniencia para el país, ya que son instrumentos para integrar nuestro quehacer económico a nivel mundial, y nuestro deber es el de luchar para que el sector agropecuario tenga oportunidad de subsistir competitivamente según esas nuevas reglas y

Matemática para la familia

OpenAIRE

Cittadino, José

1994-01-01

Para muchos profesores de matemáticas ha sido de primordial interés encontrar estrategias didácticas apropiadas para orientar el aprendizaje de las matemáticas escolares de los niños (as) y jóvenes de manera que las clases se conviertan en encuentros agradables y la relación matemática-aprendizaje- profesor sea la mejor.

Educación para emprender, una opción para el mundo en desarrollo

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Luis Gerardo Rodríguez

2015-05-01

Full Text Available RESUMEN La búsqueda de las formas educativas para corresponder con el momento histórico que vive el mundo de hoy, ha sacudido de reformas, adecuaciones y reconversiones, la geografía de nuestros países aspirantes al desarrollo. En Latinoamérica la reforma educativa es una constante y este fenómeno implica, que como educadores estemos obligados a asumir en mayor o menor proporción, el impacto de tal explosión reformista. Construir desde el quehacer cotidiano, formas de educación para orientar de manera coherente la formación de hombres para dirigir organizaciones en el mundo  de hoy, implica general un proceso educativo acorde con la reforma de la educación superior en el macro de la apertura y globalización  de la economía, y  la cual problemática social en la que se vislumbran la inestabilidad del futuro, plasmada en la crisis de la certeza y el reto de la complejidad

Um Termômetro para as Macro-Prudenciais

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Fabio Kanczuk

2013-12-01

Full Text Available Desenvolvemos um modelo com fricções no crédito tanto para firmas como famílias. Crédito às firmas é tratado como nos modelos de acelerador financeiro (e.g. Bernanke e Gilchrist (1999. Os juros sobre os recursos emprestados às famílias dependem de seu endividamento, como em Curdia e Woodford (2010. O modelo é estimado para o Brasil, utilizado para estudar os episódios de desaceleração, e para a extração dos prêmios de financiamento (destilados a partir de dados não financeiros, os quais são comparados com informações sobre crédito às pessoas físicas e jurídicas. Dessa forma, o obtém-se um termômetro para mensurar como medidas prudenciais sobre o crédito afetam atividade e inflação.

105 K east ion exchange and cartridge filter restart instrumentation acceptance test report

International Nuclear Information System (INIS)

Whitehurst, R.

1996-01-01

Acceptance Test Report following the completion of ATP-012 for the 105KE CP-A and CP-A Computer and PLC Panels. The test was conducted from 11/13/95 to 12/11/95. Three test discrepancies were generated during the ATP and all were dispositioned and closed. All sections were completed except Section 5.9 which was deleted per ECN 190556

Metodologia de la Administración Federal de Aviación para el Diseño de estructuras de Pavimento flexible para aeropuertos

Directory of Open Access Journals (Sweden)

Julián Rodrigo Quintero González

2013-08-01

Full Text Available Se representan los aspectos técnicos fundamentales y principalesconsideraciones de la metodologia propuesta por la Administracion Federal de Aviación FAA para el diseño de estructuras de pavimento para aeropuertos. Se exponen los aspectos sobre las variables consideradas en el diseño (estructurales tránsito, factores ambientales y factores intrinsecos, se establecen las caracteristicas de las variables consideradas por el metodo (subrasante y materiales para la estructura, geometría del tren de aterrizaje, número de decolajes equivalentes y peso bruto maximo del decolaje y se explica el procedimiento utilizado para el tratamiento de la información requerida en diseño estructural de pavimentos flexibles para aeropuertos.

Construyendo campos para el aprendizaje creativo. Método del juego

Directory of Open Access Journals (Sweden)

Paco Cerezo Sánchez

2008-01-01

Full Text Available Este documento presenta el marco teórico, el camino recorrido y los resultados de una experiencia piloto para la formación de formadores y de trabajadores del sector de transportes, experiencia hecha para desarrollar competencias interpersonales.Avanzamos desde el constructivismo y proponemos un método de aprendizaje en grupo, denominado Método del juego porque se basa en juegos sociales experienciados por los participantes (alumnos durante el taller.Aquí, hablo de los contenidos formativos - dirigidos especialmente a la formación de formadores- y también de la forma de aprender y de la estructura oculta en los procesos de aprendizaje. Describo un marco teórico que permite aplicar métodos de aprendizaje grupal y creativo para la formación continua, y aporto herramientas para que los formadores las adapten y construyan sus propios juegos didácticos. El marco creativo de aprendizaje y este método del juego nacen de experiencias entrenando a actores de teatro de calle (desde 1983, formadores y directivos (desde 1991 y aplicaciones para eLearning (1996-2007 en diferentes sectores y países europeos; experiencia consolidada con el equipo de www.formador.org (2005-2008. Al principio usaba juegos extraídos del circo, ahora son juegos sociales o de mesa.El marco creativo y el método del juego aquí propuestos sirven para desarrollar: el potencial humano, la autonomía personal, la creatividad y la innovación, las competencias interpersonales, de trabajo en equipo, para comprender y solucionar conflictos; la habilidad para comprender y solucionar problemas complejos; la habilidad para aprender a aprender.Así, esta propuesta para aprender jugando en grupo recoge las experiencias acumuladas durante 20 años formando formadores y complementa a otras investigaciones y productos1, muchos de ellos específicos para la formación de formadores. Para Aprender jugando en grupo hemos creado un paquete integrado por el marco teórico creador de

A Multilevel Consideration of Service Design Conditions

DEFF Research Database (Denmark)

Karpen, Ingo; Gemser, Gerda; Calabretta, Giulia

2017-01-01

Purpose: The purpose of this paper is to advance the current understanding of organisational conditions that facilitate service design. Specifically, the focus is on organisational capabilities, interactive practices and individual abilities as units of analysis across service system levels....... Grounded in design principles, the paper conceptualises and delineates illustrative service design conditions and introduces a respective service design capability-practice-ability (CPA) portfolio. In doing so, an emerging microfoundations perspective in the context of service design is advanced. Design....../methodology/approach: Conceptual paper. Findings: This paper identifies and delineates a CPA that contributes to service design and ultimately customer experiences. The service design CPA consists of six illustrative constellations of service design capabilities, practices and abilities, which operate on different organisational...

Confianza y capital social: evidencia para México

Directory of Open Access Journals (Sweden)

Rubén Martínez-Cárdenas

2015-01-01

Full Text Available Desde la perspectiva económica la confianza entre los miembros de una sociedad está asociada al funcionamiento eficiente de los mercados, al reforzamiento de contratos y, en general, a la capacidad para generar desarrollo y bienestar. En este artículo exploramos empíricamente los determinantes de la confianza en México, en particular, aislamos la relación entre dos medidas de capital social, una para el individuo y otra para su entorno. Nuestros resultados muestran que la confianza aumenta con estas medidas de capital social y con ausencia de se - gregación es mayor en comunidades pequeñas, a mayor edad y para habitantes del centro-occidente, entre otras.

ESPIRITUALIDADE PARA OUTRO MUNDO POSSÍVEL

Directory of Open Access Journals (Sweden)

Agenor Brighent

2007-01-01

Full Text Available Teve lugar, em Nairobi, o II Fórum Mundial de Teologia e Libertação, entre os dias 16e 19de janeiro de 2007.O primeiro havia sido realizado em Porto Alegre, em janeiro de 2005, cujos resultados estão publicados em L.C. SUSIN (org., Teologia para outro mundo possível, São Paulo: Paulinas, 2006 (485 pp.. O segundo teve como tema - "espiritualidade para outro mundo possível". Fizeram-se presentes 300participantes, oriundos dos cinco Continentes, em sua maioria da África, especialmente de Nairobi, seguida da Europa, América, Ásia e Oceania, respectivamente. Para além da reflexão e dos conteúdos, o simples encontro e cruzamento de buscas e realizações em esfera planetária, já justifica por si só o evento. Em tempos de crise de paradigmas e dos metarrelatos, a experiência se erige como lugar privilegiado para repensar a razão e as razões do existir, do mundo e da fé. Os trabalhos tiveram lugar no Carmelite Center, nos arredores da contrastante capital do Quênia.

Tithonia diversifolia: especie para ramoneo en sistemas silvopastoriles y métodos para estimar su consumo.

Directory of Open Access Journals (Sweden)

Estefanía Mejía-Díaz

2016-12-01

Full Text Available El objetivo del presente trabajo fue recopilar avances investigativos sobre aspectos agronómicos, nutricionales y productivos de T. diversifolia Hemsl. A Gray en sistemas silvopastorils (SSP como estrategia de producción ganadera y conocer metodologías para estimar el consumo de forraje de vacas bajo SSP. La introducción de sistemas silvopastoriles proporciona una vegetación estrati cada, además de generar diversos bienes, servicios ambientales y bienestar animal, constituyéndose, desde el punto de vista productivo, ecológico, económico y social, en una de las modalidades más prometedoras de los sistemas agroforestales. En la presente revisión se realizó una descripción de la arbustiva T. diversifolia Hemsl. A Gray, como especie estratégica para ser introducida en los sistemas silvopastoriles sean estos de baja o alta densidad, la cual por su calidad composicional ha sido reportada como una arbustiva con potencial para ser utilizada en la nutrición de rumiantes, teniendo un posible efecto positivo sobre índices productivos y económicos. Se discutieron tres técnicas utilizadas para estimar el consumo de forraje por bovinos en pastoreo, las cuales pueden ser aplicadas tanto en sistemas tradicionales como en sistemas silvopastoriles.

ParaChoice Model.

Energy Technology Data Exchange (ETDEWEB)

Heimer, Brandon Walter [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Levinson, Rebecca Sobel [Sandia National Lab. (SNL-CA), Livermore, CA (United States); West, Todd H. [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

2017-12-01

Analysis with the ParaChoice model addresses three barriers from the VTO Multi-Year Program Plan: availability of alternative fuels and electric charging station infrastructure, availability of AFVs and electric drive vehicles, and consumer reluctance to purchase new technologies. In this fiscal year, we first examined the relationship between the availability of alternative fuels and station infrastructure. Specifically, we studied how electric vehicle charging infrastructure affects the ability of EVs to compete with vehicles that rely on mature, conventional petroleum-based fuels. Second, we studied how the availability of less costly AFVs promotes their representation in the LDV fleet. Third, we used ParaChoice trade space analyses to help inform which consumers are reluctant to purchase new technologies. Last, we began analysis of impacts of alternative energy technologies on Class 8 trucks to isolate those that may most efficaciously advance HDV efficiency and petroleum use reduction goals.

Modificación del caldo extracto de levadura manitol para la producción a mediana escala de inoculantes para leguminosas

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Ernesto Ormeño-Orrillo

2014-06-01

Full Text Available El caldo extracto de levadura manitol (LM, un medio ampliamente utilizado para el cultivo de rizobios, fue modificado para reducir su costo y utilizarlo en la producción a mediana escala de inoculantes para leguminosas. Los dos ingredientes más costosos, el extracto de levadura y el manitol, fueron reducidos o reemplazados con substratos más económicos. Se pudo reducir la concentración de extracto de levadura a 0,05 g/L sin afectar el crecimiento cuando se agregó 1,1 g/L de ácido glutámico o glutamato de sodio grado alimento. El manitol pudo ser substituido por 12,5 g/L de glicerina grado farmacéutico para las cepas de Bradyrhizobium o por 10 g/L de azúcar grado alimento para las cepas de Rhizobium. No se alteraron las propiedades simbióticas de las cepas cultivados en los medios modificados.

Plan de negocio para una empresa que alquila bombas sumergibles para el sector minero

OpenAIRE

Pérez León Corzo, Stepahnie Pamela

2016-01-01

El presente trabajo de investigación evalúa la viabilidad operativa y financiera para operar una pequeña empresa dedicada al alquiler de bombas sumergibles para la actividad de desagüe de medianas y pequeñas empresas del sector minero. Estructuralmente, la empresa estará constituida por la alta dirección conformada por tres socios quienes aportarán el 30% de la inversión inicial, el 70% restante se obtendrá mediante un financiamiento a mediano plazo con un banco local. La línea media estará c...

Experimental study of para- and ortho-H3+ recombination

International Nuclear Information System (INIS)

Plasil, R; Varju, J; Hejduk, M; Dohnal, P; KotrIk, T; Glosik, J

2011-01-01

Recombination of H 3 + with electrons is a key process for many plasmatic environments. Recent experiments on storage ring devices used ion sources producing H 3 + with enhanced populations of H 3 + ions in the para nuclear spin configuration to shed light on the theoretically predicted faster recombination of para states. Although increased recombination rates were observed, no in situ characterization of recombining ions was performed. We present a state selective recombination study of para- and ortho-H 3 + ions with electrons at 77 K in afterglow plasma in a He/Ar/H 2 gas-mixture. Both spin configurations of H 3 + have been observed in situ with a near infrared cavity ring down spectrometer (NIR-CRDS) using the two lowest energy levels of H 3 + . Using hydrogen with an enhanced population of H 2 molecules in para states allowed us to influence the [para-H 3 + ]/[ortho-H 3 + ] ratio in the discharge and in the afterglow. We observed an increase in the measured effective recombination rate coefficients with the increase of the fraction of para-H 3 + . Measurements with different fractions of para-H 3 + at otherwise identical conditions allowed us to determine the binary recombination rate coefficients for pure para-H 3 + p α bin (77 K) = (2.0±0.4)x10 -7 cm 3 s -1 and pure ortho-H 3 + o α bin (77 K) = (4±3)x10 -8 cm 3 s -1 .

Experimental study of para- and ortho-H3+ recombination

Science.gov (United States)

Plašil, R.; Varju, J.; Hejduk, M.; Dohnal, P.; Kotrík, T.; Glosík, J.

2011-07-01

Recombination of H3+ with electrons is a key process for many plasmatic environments. Recent experiments on storage ring devices used ion sources producing H3+ with enhanced populations of H3+ ions in the para nuclear spin configuration to shed light on the theoretically predicted faster recombination of para states. Although increased recombination rates were observed, no in situ characterization of recombining ions was performed. We present a state selective recombination study of para- and ortho-H3+ ions with electrons at 77 K in afterglow plasma in a He/Ar/H2 gas-mixture. Both spin configurations of H3+ have been observed in situ with a near infrared cavity ring down spectrometer (NIR-CRDS) using the two lowest energy levels of H3+. Using hydrogen with an enhanced population of H2 molecules in para states allowed us to influence the [para-H3+]/[ortho-H3+] ratio in the discharge and in the afterglow. We observed an increase in the measured effective recombination rate coefficients with the increase of the fraction of para-H3+. Measurements with different fractions of para-H3+ at otherwise identical conditions allowed us to determine the binary recombination rate coefficients for pure para-H3+ pαbin(77 K) = (2.0±0.4)×10-7 cm3s-1 and pure ortho-H3+ oαbin(77 K) = (4±3)×10-8 cm3s-1.

Exhibidor de cinturones para Montagne

OpenAIRE

Galletti, Julia

2017-01-01

En el exhibidor de cinturones diseñado para la marca de ropa deportiva Montagne se produjo un trabajo estético-formal en relación a la simbología característica de la marca. Su principal característica es ser un exhibidor 360°, es decir que desde cualquier punto de vista se puede obtener un buen panorama del producto expuesto. Está confeccionado en materiales livianos para facilitar su movilidad dentro del local estipulado (exhibición en vidriera o mostrador). Asimismo, es totalmente desarmab...

Educación para un nuevo humanismo

Directory of Open Access Journals (Sweden)

GUILLERMO HOYOS-VÁSQUEZ

2009-01-01

Full Text Available Se parte del tema de la responsabilidad social universitaria, evaluada muchas veces con base en indicadores, especialmente de pertinencia. Se advierten los peligros que esto conlleva para la educación en general, si no se toma como punto de partida el sentido mismo de universidad y de educación, es decir, si no se parte de la identidad propia de las instituciones educativas. Se sugiere, por tanto, volver a retomar la discusión en torno a la formación humanista en los procesos educativos, para lo cual se analizan muy brevemente la Carta sobre el humanismo, de Martin Heidegger; las Normas para el parque humano, de Peter Sloterdijk; la Universidad sin condición, de Jacques Derrida y El cultivo de la humanidad, de Martha Nussbaum. Se cierra el ensayo con la propuesta de Jürgen Habermas de una teoría comunicativa de la educación para la ciudadanía.

Actividad Física: Pasaporte Para La Salud

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Sandra M.M. MATSUDO

2012-05-01

Full Text Available Las nuevas recomendaciones de actividad física para la salud, que cuentan con la aprobación de la oms, el cdc, el Colegio Americano de Medicina Deportiva (acsm y la American Heart Association, enfatizan que al menos 30 minutos diarios, por lo menos cinco días de la semana (de preferencia todos los días de la semana, de forma continua o en sesiones acumuladas de 10 o 15 minutos, de una actividad de intensidad moderada pueden ser suficientes para traer beneficios para la salud y la prevención, tratamiento, control y rehabilitación de las enfermedades crónicas no transmisibles. Por lo tanto, los especialistas en ciencias del deporte y las autoridades sanitarias recomiendan que toda persona incluya en su vida cotidiana, ya sea en el hogar, en el trabajo o en la comunidad, una actividad física regular para recuperar o mantener la salud.

Proposta de um instrumento para avaliar eventos adversos em odontologia

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Claudia Dolores Trierweiler Sampaio de Oliveira Corrêa

2017-11-01

Full Text Available Resumo: O objetivo deste estudo foi propor um conjunto de rastreadores para a pesquisa de eventos adversos em odontologia ambulatorial no Brasil. O instrumento foi elaborado em duas etapas: (i para construir um conjunto preliminar de rastreadores foi realizada uma revisão da literatura, a fim de identificar a composição das ferramentas de rastreamento utilizadas nas demais áreas da saúde e os principais eventos adversos encontrados em odontologia; (ii para validar os rastreadores preliminarmente construídos foi organizado um painel de especialistas empregando o método Delphi modificado. Foram elaborados quatorze rastreadores para compor um instrumento com critérios explícitos para identificar potenciais eventos adversos no cuidado odontológico, essenciais para os estudos de revisão retrospectiva de prontuários. Pesquisas relacionadas à segurança do paciente em odontologia ainda são bastante incipientes em relação às demais áreas da saúde. Este trabalho pretendeu contribuir para a investigação nesse campo. O aporte da literatura e a ajuda da expertise do painel de especialistas permitiram a elaboração de um conjunto de rastreadores para a detecção de eventos adversos odontológicos, no entanto, são necessários estudos adicionais para testar a validade do instrumento.

Sistemática para avaliação da conformidade: uma proposta para uso de cão-guia

OpenAIRE

Brito, Joana D'Arc de

2009-01-01

O objetivo do presente estudo é identificar e propor quais os principais requisitos para a Avaliação dos Centros de Treinamento, de Treinadores e dos Instrutores Autônomos de cães-guia, de forma a atender o que prescreve a Lei n.º 11.126, de 27 de junho de 2005 no concernente às necessidades de adaptação dos segmentos envolvidos. Esta pesquisa foi estruturada em 3 (três) etapas. No primeiro momento utilizou-se de fontes bibliográficas para o levantamento de obras de referência para o desenvol...

Creación de materiales didácticos orales para la clase de lengua para la traducción

OpenAIRE

González Royo, Carmen; Chiapello, Stefania; Martín Sánchez, Teresa; Pascual Escagedo, Consuelo; Puigdevall Balafuy, Núria; Mura, G. Angela; Regagliolo, Alberto

2016-01-01

“Creación de materiales didácticos orales para la clase de lengua para la traducción” (3546) es una red que, desde una perspectiva de investigación-acción, investiga la implementación de materiales docentes para los currículos de lengua y traducción en las asignaturas de E/LE e I/LE en los grados de Lenguas Extranjeras y Traducción e Interpretación de la Universidad de Alicante, Università Suor Orsola Benincasa de Nápoles y Università degli Studi di Salerno. A partir de los materiales produci...

Knowledge and awareness of Consumer Protection Act among private dentists in Tricity, Punjab.

Science.gov (United States)

Gambhir, Ramandeep Singh; Dhaliwal, Jagjit Singh; Anand, Samir; Bhardwaj, Arvind

2015-01-01

Consumer Protection Act (CPA) aims to protect the interests of the patients in case of any unethical treatment rendered by a medical or a dental health professional. The present study was conducted to assess knowledge and awareness of CPA among dental professionals in a Tricity in India. A cross-sectional study was conducted among 265 private dental practitioners in Tricity. A close-ended self-structured questionnaire was administered which contained 15 questions on knowledge and awareness regarding CPA. Categorization of knowledge scores was done at three levels-low, medium and high. Statistical analysis was done using ANOVA and Student t-test. 54.7% (145) of subjects were having low knowledge scores, 23.3% (62) had a medium score and 21.8% (58) had a high score. Mean knowledge score according to educational level was statistically significant (P 0.05). The results of the present study showed that majority of the subjects were aware of the existence of CPA but knowledge regarding basic rules and regulations was lacking in few studies. Therefore, dental professionals need to keep them updated of various rules and latest amendments to save themselves from any litigation.

Weaving the health and pharmaceutical care agenda through the themes of the commonwealth heads of government meeting (CHOGM), London 2018.

Science.gov (United States)

Rutter, Victoria; Chan, Amy Hai Yan; Tuck, Chloe; Bader, Lina; Babar, Zaheer-Ud-Din; Bates, Ian

2018-01-01

The biennial Commonwealth Heads of Government Meeting (CHOGM) this year is based around four key themes: prosperity, fairness, sustainability and security. This is an opportune time to consider the role of pharmacists in healthcare delivery, and particularly their contribution to achieving the United Nations Sustainable Development Goals (SDGs). As a member of the Commonwealth Health Professions Alliance (CHPA), the Commonwealth Pharmacists Association (CPA) has been working to ensure that pharmacy-related aspects of health are represented in the advocacy papers submitted by Civil Society. Echoing the CHPA's priorities around SDG 3 (health) and the attainment of sustainable universal health coverage (UHC), the CPA has been raising the profile of key priorities for our members, including: addressing the shortage of healthcare workers (with an emphasis on pharmacists); need for access to quality medicines and medicines information; tackling anti-microbial resistance and substandard/falsified medicines; and championing the role of digitalisation and partnerships. This editorial discusses how the work of the CPA links with the themes of CHOGM, the CPA's input into this meeting and the direction of travel 'Towards a Common Future' for health and pharmacy in the Commonwealth.

Production and characterization of biodiesel using palm kernel oil; fresh and recovered from spent bleaching earth

Directory of Open Access Journals (Sweden)

Abiodun Aladetuyi

2014-12-01

Full Text Available Palm kernel oil (PKO was recovered from spent bleaching earth with a yield of 16 %, using n-hexane while the fresh oil was extracted from palm kernel with n-hexane and a yield of 40.23% was obtained. These oils were trans-esterified with methanol under the same reaction conditions: 100 oC, 2 h reaction time, and oil-methanol ratio of 5:1 (w/v. The cocoa pod ash (CPA was compared with potassium hydroxide (KOH as catalyst. The percentage yields of biodiesel obtained from PKO catalysed by CPA and KOH were 94 and 90%, respectively. While the yields achieved using the recovered oil catalysed by CPA and KOH were measured at 86 and 81.20 %. The physico-chemical properties of the biodiesel produced showed that the flash point, viscosity, density, ash content, percentage carbon content, specific gravity and the acid value fell within American Society for Testing and Materials (ASTM specifications for biodiesel. The findings of this study suggest that agricultural residues such as CPA used in this study could be explored as alternatives for KOH catalyst for biodiesel production.

Knowledge and awareness of Consumer Protection Act among private dentists in Tricity, Punjab

Directory of Open Access Journals (Sweden)

Ramandeep Singh Gambhir

2015-01-01

Full Text Available Background: Consumer Protection Act (CPA aims to protect the interests of the patients in case of any unethical treatment rendered by a medical or a dental health professional. The present study was conducted to assess knowledge and awareness of CPA among dental professionals in a Tricity in India. Materials and Methods: A cross-sectional study was conducted among 265 private dental practitioners in Tricity. A close-ended self-structured questionnaire was administered which contained 15 questions on knowledge and awareness regarding CPA. Categorization of knowledge scores was done at three levels-low, medium and high. Statistical analysis was done using ANOVA and Student t-test. Results: 54.7% (145 of subjects were having low knowledge scores, 23.3% (62 had a medium score and 21.8% (58 had a high score. Mean knowledge score according to educational level was statistically significant (P 0.05. Conclusion: The results of the present study showed that majority of the subjects were aware of the existence of CPA but knowledge regarding basic rules and regulations was lacking in few studies. Therefore, dental professionals need to keep them updated of various rules and latest amendments to save themselves from any litigation.

Theory of bulk and interface constant phase elements in electrode- electrolyte systems

International Nuclear Information System (INIS)

Liu, S.H.

1991-01-01

This paper summarizes the progress gained in the last few years in our understanding of bulk and interface constant-phase-angle (CPA) behavior in electrode-electrolyte systems. It is now fairly well established that the interface constant-phase element originates from the fractal nature of the interface. The complex geometry gives rise to a fractal distribution of parallel current paths, and the competition between these paths results in the fractional power law behavior of the impedance across the interface. On the other hand, the early hope of relating the CPA exponent to the fractal dimension of the interface has been shown to be unattainable. Our understanding of the bulk CPA behavior, which is most prevalent in solid electrolytes, is only tentative. It is illustrated using a simple model that, under nonlinear dynamical laws that govern the flow of ions in the electrolyte, a current in the solid can generate a fractal distribution of vacancies which tend to impede the flow. The current is forced to negotiate a complex path through the solid, and the resulting fluctuation in path length and flow rate could be a source of the CPA behavior. 32 refs., 18 figs

Sensorineural hearing loss among cerebellopontine-angle tumor patients examined with pure tone audiometry and brainstem-evoked response audiometry

Science.gov (United States)

Rinindra, A. M.; Zizlavsky, S.; Bashiruddin, J.; Aman, R. A.; Wulani, V.; Bardosono, S.

2017-08-01

Tumor in the cerebellopontine angle (CPA) accurs for approximately 5-10% of all intracranial tumors, where unilateral hearing loss and tinnitus are the most frequent symptoms. This study aimed to collect data on sensorineural hearing loss in CPA tumor patients in Dr. Cipto Mangunkusumo Hospital (CMH) using pure tone audiometry and brainstem-evoked response audiometry (BERA). It also aimed to obtaine data on CPA-tumor imaging through magnetic resonance imaging (MRI). This was a descriptive, analytic, and cross-sectional study. The subjects of this study were gathered using a total sampling method from secondary data between July 2012 and November 2016. From 104 patients, 30 matched the inclusion criteria. The CPA-tumor patients in the ENT CMH outpatient clinic were mostly female, middle-aged patients (41-60 years) whose clinical presentation was mostly tinnitus and severe, asymmetric sensorineural hearing loss in 10 subjects. From 30 subjects, 29 showed ipsilaterally impaired BERA results, and 17 subjects showed contralaterally impaired BERA results. There were 24 subjects who with large-sized tumors and 19 subjects who had intracanal tumors that had spread until they were extracanal in 19 subjects.

TV Móvel: onde estamos e para onde vamos

Directory of Open Access Journals (Sweden)

Clara-Luz Álvarez

2010-05-01

Full Text Available O artigo apresenta (1 as características técnicas da TV Móvel [Mobile TV] e sua diferença para o IPTV e a TV pela Internet [Internet TV], (2 as questões relativas a rede, espectro e equipamento que influenciarão o arcabouço normativo, (3 as oportunidades geradas para a TV Móvel quando da migração para a TV digital, e (4 um estudo de caso do México pertinente ao marco regulatório dos serviços de telecomunicações e de radiodifusão, aos atores do mercado, à disponibilidade de espectro, à migração para a TV digital e outras questões proeminentes para a TV Móvel.

Preparar para el futuro: el rol del educador

Directory of Open Access Journals (Sweden)

Myrna A. Cuevas Ruiz

2000-12-01

Full Text Available El artículo aborda el problema de la educación a la luz de las esperanzas y exigencias que se le plantean y de sus posibilidades reales para responder a los retos. En este marco, ubica la figura del educador, las cualidades que deben caracterizarlo para responder a las demandas de los retos educativos y los requerimientos que, en el contexto de la profesión docente, deben satisfacerse para impulsar los cambios.

QRLabel y Blackbird: 2 aplicaciones accesibles para Android

OpenAIRE

Mercade Aguila, Gisela

2012-01-01

El objetivo de este proyecto es el de realizar dos aplicaciones para dispositivos móviles con sistema operativo Android. Estas aplicaciones están ideadas para ser usadas por una persona invidente o con deficiencias visuales. El transcurso del desarrollo de cada aplicacion sirve para conocer y experimentar con diferentes herramientas que dispone este sistema operativo, y de este modo estudiar sus ventajas y limitaciones. Se presentan dispositivos y prototipos de dispositivos diseñados exclusiv...

Análise do EIA/RIMA do Terminal de Combustíveis da Paraíba (TECOP para fins de licenciamento ambiental

Directory of Open Access Journals (Sweden)

Valdeniza Delmondes Pereira

2016-09-01

Full Text Available O estudo de impacto ambiental precede ao licenciamento ambiental, sendo obrigatório para atividades efetiva ou potencialmente poluidoras ou capazes de degradar o meio ambiente. Este trabalho teve como objetivo fazer a análise do EIA/RIMA do Terminal de Combustíveis da Paraíba Ltda-TECOP, observando se foram cumpridas as exigências legais para a caracterização dos impactos ambientais, e verificando também a existência de medidas mitigadoras para os impactos adversos e indicação de monitoramento para os referidos impactos identificados. Trata-se de uma pesquisa descritiva e documental, que teve como objetos de estudo, o EIA/RIMA e o Processo de Licenciamento Ambiental do TECOP, cujos dados foram coletados junto ao Setor de Documentação da SUDEMA. O EIA/RIMA se mostrou extremamente superficial no que diz respeito à caracterização dos impactos ambientais, estes não sendo devidamente caracterizados conforme determina a Resolução Conama 01/86, artigo 6, inciso II. Os atributos para a correta caracterização dos impactos não foram levados em consideração sequer para os principais impactos adversos passíveis de ocorrerem na fase de operação do empreendimento. O estudo também não mostrou clareza quanto à proposição das medidas mitigadoras e monitoramento para os impactos identificados, pois nem todos os impactos adversos continham a indicação de mitigação e como seriam monitorados.

Modelos para gestão de riscos em cadeias de suprimentos: revisão, análise e diretrizes para futuras pesquisas

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Robson Nogueira Tomas

2013-01-01

Full Text Available O objetivo deste artigo é apresentar uma revisão bibliográfica, que possa ser considerada completa e inédita na literatura científica nacional, tendo como foco modelos para gestão de riscos em cadeias de suprimentos. Para tanto, foram revisados 103 artigos científicos publicados entre 2000 e 2012. Inicialmente, buscou-se categorizar os tipos de riscos abordados nos artigos científicos segundo a descrição proposta por Christopher e Peck (2004, a saber: internos à empresa focal (operações, processo e controle; externos para a empresa focal, mas internos para a cadeia (fornecimento e demanda; e externos à cadeia (macroambiente. Buscou-se, também, identificar as etapas elementares na composição de um modelo para gestão de riscos em cadeias de suprimentos. Uma vez categorizados os tipos de riscos e identificadas as quatro etapas elementares, efetuou-se uma análise a partir de três perspectivas: i as opções de modelos disponíveis na literatura para a prática de tal gestão, considerando-se os tipos de riscos e etapas que os compõem; ii um modelo final a ser proposto; e iii elementos que podem ser acrescentados ao modelo final. As principais contribuições deste trabalho dizem respeito a possibilitar melhor entendimento dos tipos de riscos que podem incidir sobre uma cadeia de suprimentos, discutir os modelos mais adequados para geri-los, além de oferecer diretrizes para futuras pesquisas na temática em questão.

Construcción de un indicador para medir competencias básicas para la vida

OpenAIRE

Andrea Collado Chaves

2006-01-01

La necesidad de construir un indicador para cuantificar el nivel de Competencias Básicas para la Vida (CBV), nace con la evaluación los resultados de un proyecto dirigido a población joven. El propósito de ese proyecto es construir capital humano y empleabilidad en hombres y mujeres con edades entre 13 y 18 años, desertores o en riesgo de desertar del sistema educativo, sin empleo formal y que viven en ambientes de pobreza y exclusión. Una de las dimensiones de empleabilidad son las Competenc...

MODELO PARA LA GESTIÓN DEL CONOCIMIENTO ORGANIZACIONAL EN LA SUITE PARA LA DIRECCIÓN INTEGRADA POR PROYECTOS GESPRO

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Anisleiby Fernández Hernández

2014-06-01

Full Text Available La economía mundial se dirige hacia un nuevo modelo basado en el conocimiento, aportando ventajas competitivas gracias a su gestión. La Dirección Integrada por Proyectos requiere de la aplicación de un modelo para la gestión del conocimiento, con el objetivo de garantizar la elevación de la calidad de los nuevos proyectos. En el trabajo se presenta un modelo que combina y complementa diferentes estrategias para identificar, adquirir, retener, desarrollar y utilizar el conocimiento necesario en la realización de los proyectos, apoyadas por el uso de las Tecnologías de la Informática y las Comunicaciones. Este modelo responde y está en correspondencia con la versión 13.05 de la Suite para la Dirección Integrada por Proyectos Gespro de Software libre perteneciente a la Universidad de las Ciencias Informáticas, que se presenta como proceso para la gestión del conocimiento.

"Colaborar para Competir"

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Martha Liliana Hijuelos-Cárdenas

2015-06-01

Full Text Available De acuerdo con Michael Porter, los Clusters se definen como “Una agrupación de empresas e instituciones relacionadas entre sí, pertenecientes a un mismo sector o segmento de mercado, que se encuentran próximas geográficamente y que colaboran para ser más competitivas”. Los Clusters son en última instancia una herramienta de competitividad basada en la cooperación de sus miembros, y es una de las estrategias recientes, en el país, para incrementar la productividad y competitividad y las apuestas productivas desde el nivel local. Y es precisamente esta cercanía geográfica de las empresas de un mismo sector, lo que a la vez que genera la competencia entre ellas, también les facilita el acceso a insumos y a conocimientos específicos y en última instancia les permite promover la innovación.

ParaTrough v1.0: Librería en Modelica para Simulación de Plantas Termosolares

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Juan A. Romera Cabrerizo

2017-10-01

Full Text Available Resumen: El presente trabajo describe una librería desarrollada en Modelica que utiliza el entorno Dymola 6.1 para modelar y simular plantas termosolares de tecnología de colector cilindro-parabólico. El actual software de modelado y simulación es cada vez más potente gracias a los avances en computación y programación, pudiendo conseguir estimaciones muy precisas del comportamiento de estas plantas térmicas. Como mejora a otras propuestas actuales, la librería ParaTrough se ofrece como una herramienta pública, gratuita bajo licencia Modelica License 2, de código libre, flexible, modular, y por lo tanto fácilmente ampliable y modificable para los requerimientos específicos de cada planta y proceso en particular. En la versión 1.0 contemplada en este artículo, esta librería se puede usar para el modelado y simulación del recurso solar y del sistema de fluido de transferencia calorífica sin cambio de fase. Los modelos han sido validados con datos reales de una planta en operación, Andasol 3, en los términos municipales de Aldeire y La Calahorra (Granada. El objetivo de ParaTrough es poder ser utilizada gratuitamente y de forma amigable por analistas de procesos para uno o varios de los siguientes casos: evaluación del rendimiento, detección de fallos, exploración de nuevos modos de operación y optimización de la planta. Aunque en futuras versiones se puedan añadir otros elementos, esta aportación cubre una nueva área de aplicación específica para el software de Modelica y en su estado actual facilita la operación y mantenimiento de estas plantas. Abstract: This paper describes a Modelica-based library developed to the modeling and simulation of solar thermal plants with parabolic trough collectors. The Dymola 6.1 environment has been used. Unlike other commercial tools, the ParaTrough library is offered as a free open source tool, under Modelica License 2. Its modular code makes it easily extensible and modifiable to

Framework Multi-LIBRAS para integração e colaboração de soluções para deficientes auditivos

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Luciana Pereira Oliveira

2017-08-01

Full Text Available Vem crescendo o número de soluções para pessoas com deficiência auditiva. Por exemplo, vêm surgindo diversas soluções de tradutores de Português para LIBRAS para facilitar a comunicação entre ouvintes e surdos. Por outro lado, muitos projetos de pesquisa estão descontinuados, não sendo possível executar os aplicativos desenvolvidos e muito menos repetir experimentos descritos nos artigos. Então, como os pesquisadores poderiam trabalhar de maneira colaborativa a construção de novos aplicativos e melhorias dos softwares existentes? Seria possível distintos grupos de pesquisa criarem um dicionário de Português e LIBRAS aberto? Objetivando-se esse ambiente colaborativo, definiu-se o framework Multi-LIBRAS, que oferece flexibilidade e extensibilidade para integrar qualquer solução para LIBRAS e algoritmos de avaliação. O artigo irá apresentar uma visão geral, as camadas externas e internas do framework bem como exemplificar o uso do Multi-LIBRAS, que dá suporte a soluções descritas em qualquer linguagem de programação.

Comparison of the Calcaneal Pitch Angle and Modified Projection Area Per Length Squared Method for Medial Longitudinal Arch Evaluation of the Foot

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Esat Kıter2

2012-12-01

Full Text Available Objective: To compare the calcaneal pitch angle (CPA values measured on direct lateral radiographs of feet, and the modified projection area per length squared (PAL, which was calculated as a new method for the evaluation of the medial longitudinal arch (MLA of the foot.Material and Methods: Direct lateral radiographs of patients who had weightbearing feet radiographies for any reason except trauma were retrospectively obtained from the archives. Direct lateral radiographs of the feet were printed and a transparent sheet was placed on it. A straight line was drawn between the most plantar process of the calcaneus and the head of the first metatarsal bone for the calculation of the PAL of the MLA. Two semilunar arcs were drawn upon this straight line. PAL1 and PAL2 were estimated using a point-counting technique. The CPA, lateral talo-calcaneal angles (LTCA, and talo-first metatarsal angles (TFMA were measured. The correlations between PAL1, PAL2 of right and left feet and CPA, LTCA, and TFMA were explored.Results: Fifty patients (27 females, 23 males with a mean age of 40.12 (4-78 years were evaluated. Significant correlations were detected between PAL1, PAL2 and CPA, and TFMA for both right and left feet (p<0.05. Conclusion: A significant correlation was detected between the modified PAL method as a new technique and the standard CPA method for MLA evaluation. The PAL method is suggested as a simple and practical method for MLA evaluation.

A novel model of invasive fungal rhinosinusitis in rats.

Science.gov (United States)

Zhang, Fang; An, Yunfang; Li, Zeqing; Zhao, Changqing

2013-01-01

Invasive fungal rhinosinusitis (IFRS) is a life-threatening inflammatory disease that affects immunocompromised patients, but animal models of the disease are scarce. This study aimed to develop an IFRS model in neutropenic rats. The model was established in three consecutive steps: unilateral nasal obstruction with Merocel sponges, followed by administration of cyclophosphamide (CPA), and, finally, nasal inoculation with Aspergillus fumigatus. Fifty healthy Wistar rats were randomly divided into five groups, with group I as the controls, group II undergoing unilateral nasal obstruction alone, group III undergoing nasal obstruction with fungal inoculation, group IV undergoing nasal obstruction with administration of CPA, and group V undergoing nasal obstruction with administration of CPA and fungal inoculation. Hematology, histology, and mycology investigations were performed. The changes in the rat absolute neutrophil counts (ANCs) were statistically different across the groups. The administration of CPA decreased the ANCs, whereas nasal obstruction with fungal inoculation increased the ANCs, and nasal obstruction did not change them. Histological examination of the rats in group V revealed the hyphal invasion of sinus mucosa and bone, thrombosis, and tissue infarction. No pathology indicative of IFRS was observed in the remaining groups. Positive rates of fungal culture in tissue homogenates from the maxillary sinus (62.5%) and lung (25%) were found in group V, whereas groups I, II, III, and IV showed no fungal culture in the homogenates. A rat IFRS model was successfully developed through nasal obstruction, CPA-induced neutropenia, and fungal inoculation. The disease model closely mimics the pathophysiology of anthropic IFRS.

Research on the Changes to the Lipid/Polymer Membrane Used in the Acidic Bitterness Sensor Caused by Preconditioning

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Yuhei Harada

2016-02-01

Full Text Available A taste sensor that uses lipid/polymer membranes can evaluate aftertastes felt by humans using Change in membrane Potential caused by Adsorption (CPA measurements. The sensor membrane for evaluating bitterness, which is caused by acidic bitter substances such as iso-alpha acid contained in beer, needs an immersion process in monosodium glutamate (MSG solution, called “MSG preconditioning”. However, what happens to the lipid/polymer membrane during MSG preconditioning is not clear. Therefore, we carried out three experiments to investigate the changes in the lipid/polymer membrane caused by the MSG preconditioning, i.e., measurements of the taste sensor, measurements of the amount of the bitterness substance adsorbed onto the membrane and measurements of the contact angle of the membrane surface. The CPA values increased as the preconditioning process progressed, and became stable after 3 d of preconditioning. The response potentials to the reference solution showed the same tendency of the CPA value change during the preconditioning period. The contact angle of the lipid/polymer membrane surface decreased after 7 d of MSG preconditioning; in short, the surface of the lipid/polymer membrane became hydrophilic during MSG preconditioning. The amount of adsorbed iso-alpha acid was increased until 5 d preconditioning, and then it decreased. In this study, we revealed that the CPA values increased with the progress of MSG preconditioning in spite of the decrease of the amount of iso-alpha acid adsorbed onto the lipid/polymer membrane, and it was indicated that the CPA values increase because the sensor sensitivity was improved by the MSG preconditioning.

Pequenos para idade gestacional: fator de risco para mortalidade neonatal

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Almeida Márcia Furquim de

1998-01-01

Full Text Available OBJETIVO: Estudar as variáveis contempladas na Declaração de Nascimento (DN como possíveis fatores de risco para nascimentos pequenos para a idade gestacional (PIG e o retardo de crescimento intra-uterino como fator de risco para a mortalidade neonatal. MATERIAL E MÉTODO: As variáveis existentes na DN foram obtidas diretamente de prontuários hospitalares. Os dados referem-se a uma coorte de nascimentos obtida por meio da vinculação das declarações de nascimento e óbito, correspondendo a 2.251 nascimentos vivos hospitalares, de mães residentes, ocorridos no Município de Santo André, Região Metropolitana de São Paulo, no período de l/1 a 30/6/1992, e aos óbitos neonatais verificados nessa coorte. RESULTADOS: Obteve-se a proporção de 4,3% de nascimentos PIG, significativamente maior entre os recém-nascidos de pré-termo e pós-termo, entre os nascimentos cujas mães tinham mais de 35 anos de idade e grau de instrução inferior ao primeiro grau completo. Os recém-nascidos PIG apresentam maior risco de morte neonatal que aqueles que não apresentavam sinais de retardo de crescimento intra-uterino. CONCLUSÕES: Em áreas com menor freqüência de baixo peso ao nascer, é importante investigar a presença de retardo de crescimento intra-uterino entre os nascimentos prematuros e não apenas nos nascimentos de termo. O registro da data da última menstruação (ou da idade gestacional em semanas não agregadas na DN facilitaria a detecção de PIGs na população de recém-nascidos.

An investigation into a contactless photoplethysmographic mobile application to record heart rate post-exercise: Implications for field testing

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Peart Daniel J.

2015-08-01

Full Text Available Study aim: the aim of this study was to compare the accuracy of a contactless photoplethysmographic mobile application (CPA to record post-exercise heart rate and estimate maximal aerobic capacity after the Queen’s College Step Test. It was hypothesised that the CPA may present a cost effective heart rate measurement tool for educators and practitioners with limited access to specialised laboratory equipment.

Propuesta de implementación de un modelo de calidad para la selección de software base para servidores.

OpenAIRE

Espinel Mena, Gonzalo Patricio; Montaluisa Yugla, Franklin Javier

2012-01-01

La propuesta de implementación plantea la utilización de un modelo de calidad estructurado para ayudar a resolver el problema de adquirir paquetes de software de base que encajen normalmente dentro de un entorno organizacional. El modelo de calidad estructurado para un dominio de un paquete dado proporcionará una taxonomía de características de software de calidad, y métricas para calcular su valor. El modelo de calidad se basa la norma ISO/IEC 9126 de la ISO (Organización Internacional de No...

Desenvolvimento de uma abordagem computacional para a descoberta de compostos-líderes para fármacos anticancerígenos

OpenAIRE

Cruz, Sara Miguel Dinis Mamede da

2016-01-01

Atualmente o cancro é uma das principais causas de morte, causando uma crescente demanda para a descoberta de fármacos para o seu tratamento. O objetivo desta dissertação foi a construção de modelos computacionais para auxiliar a descoberta de novos compostos líder anticancerígenos contra o cancro do cólon. Foram realizados dois diferentes estudos da Relação Quantitativa Estrutura Atividade (QSAR), o primeiro intitulado Modelo A, que utilizou conjuntos de descritores estruturais e fingerpr...

Cubierta de madera para una nave industrial

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Hossdorf, Heinz

1958-05-01

Full Text Available Para la ampliación de los talleres de Hans Schmidlin, de Basilea, Suiza, dedicados a la prefabricación de elementos de construcción de madera y metales ligeros para fachadas, se ha construido una nueva nave, rectangular, de 49x55,4 m en planta.

Comparison and avoidance of toxicity of penetrating cryoprotectants.

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Edyta A Szurek

Full Text Available The objective of this study was to elucidate the toxicity of widely used penetrating cryoprotective agents (CPAs to mammalian oocytes. To this end, mouse metaphase II (M II oocytes were exposed to 1.5 M solutions of dimethylsulfoxide (DMSO, ethylene glycol (EG, or propanediol (PROH prepared in phosphate buffered saline (PBS containing 10% fetal bovine serum. To address the time- and temperature-dependence of the CPA toxicity, M II oocytes were exposed to the aforementioned CPAs at room temperature (RT, ∼23°C and 37°C for 15 or 30 minutes. Subsequently, the toxicity of each CPA was evaluated by examining post-exposure survival, fertilization, embryonic development, chromosomal abnormalities, and parthenogenetic activation of treated oocytes. Untreated oocytes served as controls. Exposure of MII oocytes to 1.5 M DMSO or 1.5 M EG at RT for 15 min did not adversely affect any of the evaluated criteria. In contrast, 1.5 M PROH induced a significant increase in oocyte degeneration (54.2% and parthenogenetic activation (16% under same conditions. When the CPA exposure was performed at 37°C, the toxic effect of PROH further increased, resulting in lower survival (15% and no fertilization while the toxicity of DMSO and EG was still insignificant. Nevertheless, it was possible to completely avoid the toxicity of PROH by decreasing its concentration to 0.75 M and combining it with 0.75 M DMSO to bring the total CPA concentration to a cryoprotective level. Moreover, combining lower concentrations (i.e., 0.75 M of PROH and DMSO significantly improved the cryosurvival of MII oocytes compared to the equivalent concentration of DMSO alone. Taken together, our results suggest that from the perspective of CPA toxicity, DMSO and EG are safer to use in slow cooling protocols while a lower concentration of PROH can be combined with another CPA to avoid its toxicity and to improve the cryosurvival as well.

Analysis of the corporate political activity of major food industry actors in Fiji.

Science.gov (United States)

Mialon, Melissa; Swinburn, Boyd; Wate, Jillian; Tukana, Isimeli; Sacks, Gary

2016-05-10

Non-communicable diseases (NCDs) are the leading cause of mortality in Fiji, a middle-income country in the Pacific. Some food products processed sold and marketed by the food industry are major contributors to the NCD epidemic, and the food industry is widely identified as having strong economic and political power. However, little research has been undertaken on the attempts by the food industry to influence public health-related policies and programs in its favour. The "corporate political activity" (CPA) of the food industry includes six strategies (information and messaging; financial incentives; constituency building; legal strategies; policy substitution; opposition fragmentation and destabilisation). For this study, we aimed to gain a detailed understanding of the CPA strategies and practices of major food industry actors in Fiji, interpreted through a public health lens. We implemented a systematic approach to monitor the CPA of the food industry in Fiji for three months. It consisted of document analysis of relevant publicly available information. In parallel, we conducted semi-structured interviews with 10 stakeholders involved in diet- and/or public health-related issues in Fiji. Both components of the study were thematically analysed. We found evidence that the food industry adopted a diverse range of strategies in an attempt to influence public policy in Fiji, with all six CPA strategies identified. Participants identified that there is a substantial risk that the widespread CPA of the food industry could undermine efforts to address NCDs in Fiji. Despite limited public disclosure of information, such as data related to food industry donations to political parties and lobbying, we were able to identify many CPA practices used by the food industry in Fiji. Greater transparency from the food industry and the government would help strengthen efforts to increase their accountability and support NCD prevention. In other low- and middle-income countries, it

Threat evaluation for impact assessment in situation analysis systems

Science.gov (United States)

Roy, Jean; Paradis, Stephane; Allouche, Mohamad

2002-07-01

Situation analysis is defined as a process, the examination of a situation, its elements, and their relations, to provide and maintain a product, i.e., a state of situation awareness, for the decision maker. Data fusion is a key enabler to meeting the demanding requirements of military situation analysis support systems. According to the data fusion model maintained by the Joint Directors of Laboratories' Data Fusion Group, impact assessment estimates the effects on situations of planned or estimated/predicted actions by the participants, including interactions between action plans of multiple players. In this framework, the appraisal of actual or potential threats is a necessary capability for impact assessment. This paper reviews and discusses in details the fundamental concepts of threat analysis. In particular, threat analysis generally attempts to compute some threat value, for the individual tracks, that estimates the degree of severity with which engagement events will potentially occur. Presenting relevant tracks to the decision maker in some threat list, sorted from the most threatening to the least, is clearly in-line with the cognitive demands associated with threat evaluation. A key parameter in many threat value evaluation techniques is the Closest Point of Approach (CPA). Along this line of thought, threatening tracks are often prioritized based upon which ones will reach their CPA first. Hence, the Time-to-CPA (TCPA), i.e., the time it will take for a track to reach its CPA, is also a key factor. Unfortunately, a typical assumption for the computation of the CPA/TCPA parameters is that the track velocity will remain constant. When a track is maneuvering, the CPA/TCPA values will change accordingly. These changes will in turn impact the threat value computations and, ultimately, the resulting threat list. This is clearly undesirable from a command decision-making perspective. In this regard, the paper briefly discusses threat value stabilization

Secadores solares - térmicos para granos y frutas para utilizarlo en zonas remotas

OpenAIRE

Delgado, E.; Peralta, J.; Barriga, A.

2009-01-01

Los objetivos principales de esta investigación son: • Dar a conocer la ventaja que tiene el uso de la utilización de la energía solar térmica para sistemas de secadores solares en la disminución de la humedad de los producto. • Valorar la importancia de la conservación energética y ambiental a través del uso de energía limpia. • Dar a conocer diseños de sistema de secado solar para alimentos, principalmente granos y frutas acorde a las características del producto, geográficas, técnicas y so...

Novo teste para diagnóstico das afasias

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José G. Albernaz

1953-06-01

Full Text Available Um novo teste para diagnóstico e contrôle do tratamento das diferentes formas de afasia, especialmente adaptado para a língua portuguêsa, é apresentado e descrito em detalhe. O teste, que será de valor para clínicos e psicólogos interessados no tratamento e reabilitação de pacientes afásicos, se executa em cêrca de 30 minutos, interpreta-se fàcilmente e fornece os elementos necessários para o planejamento da reeducação da linguagem. Além disso, a repetição do teste de tempos em tempos indicará os progressos do paciente e sugerirá modificações do plano de tratamento no momento oportuno.

AKTIVITAS PENGENDALIAN MUTU JASA AUDIT LAPORAN KEUANGAN HISTORIS (Studi Kasus pada Beberapa Kantor Akuntan Publik di Surabaya

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Yulius Jogi Christiawan

2005-01-01

Full Text Available The objective of this study was to get the descriptive in depth and holistic the quality control activities in several CPAs%2C in Surabaya in order to answer the audit quality questioned by the audit report user. This study was a qualitative research with multiple case studies and multiple unit analysis approach. The study was focused on the competence and independence standards as well as the control procedures and its activities by partners and managers in CPA firms. There were%3A 1%29 the CPA firms face difficult in establishing independence in fact standards and objectives%2C 2%29 the CPA firms applied the professional standard to establish independence in appearance standards and objectives%2C 3%29 the CPA firms applied human resources management function to secure personnel educational competence%2C 4%29 the CPA firms applied planning%2C supervising and performance evaluating in order to obtain experience personnel%2C and 5%29 the CPA firms give strict punishment for violation of independence and competence. Abstract in Bahasa Indonesia : Penelitian ini bertujuan mengetahui secara mendalam %28in depth%29 dan menyeluruh tentang aktivitas pengendalian mutu audit yang terjadi di beberapa Kantor Akuntan Publik di Surabaya%2C sehingga diharapkan bisa menjawab keraguan pengguna jasa audit terhadap mutu audit yang ada di kantor akuntan publik. Penelitian ini adalah penelitian kualitatif dengan menggunakan pendekatan multiple case study dengan multiple unit analysis. Penelitian diarahkan pada standar independensi dan kompetensi di Kantor Akuntan Publik serta aktivitas dan prosedur pengendalian oleh partner dan manajer Kantor Akuntan Publik. Penelitian dilakukan terhadap empat dari lima puluh satu Kantor Akuntan Publik di Surabaya. Hasil penelitian ini sedikitnya menunjukkan lima fenomena terkait dengan aktivitas pengendalian mutu Kantor Akuntan Publik. Lima fenomena tersebut adalah%3A 1%29 Kantor Akuntan Publik sulit menetapkan suatu standar%2

Os motivos das relações entre orientação para mercado, orientação para aprendizagem e sucesso de novos produtos

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Mauren do Couto Soares

2016-04-01

Full Text Available O objetivo deste trabalho é identificar os motivos das relações entre os construtos de orientação para mercado, orientação para aprendizagem e sucesso de novos produtos. Neste sentido, foram coletadas 32 entrevistas com executivos de empresas de setores representativos da economia brasileira. Os principais resultados indicam que: (1 grande parte dos motivos encontrados nas entrevistas corrobora as evidências levantadas na literatura; (2 algumas variáveis podem moderar as relações entre orientação para mercado, orientação para aprendizagem e sucesso de novos produtos, entre elas a motivação, a burocracia e os recursos humanos; e, (3 empresas que integram os construtos de orientação para mercado, orientação para aprendizagem e sucesso de novos produtos podem potencializar sua performance, facilitando a obtenção de uma vantagem competitiva sustentável.

Entrenamiento de fuerza para la salud

OpenAIRE

Ortiz Cervera, Vicente

1996-01-01

Este artículo describe de manera breve y clara los efectos del entrenamiento de fuerza sobre la salud, al mismo tiempo da pautas para la realización y programación de los entrenamientos de fuerza para la salud en distintas edades. Se muestran las diferentes variables del entrenamiento de la fuerza junto con ejemplos de entrenamientos, basándose en las pautas marcadas en la revisión bibliográfica descrita.

Páginas web para el aprendizaje

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Isabel ÁLVAREZ

2016-04-01

Full Text Available Este artículo plantea la construcción de paginas web como vehículo para facilitar la integracion de las tecnologias de la informacion y la comunicacion en el aula para futuros maestros. El término Página Web Coherente enfatiza la utilización de páginas cuyo objetivo principal es promover el aprendizaje siguiendo un proceso colaborativo, una estructura integradora y un contenido educativo.

Movement and equipositioning of plasmids by ParA filament disassembly

DEFF Research Database (Denmark)

Ringgaard, Simon; van Zon, Jeroen; Howard, Martin

2009-01-01

, plasmids consistently migrate behind disassembling ParA cytoskeletal structures, suggesting that ParA filaments pull plasmids by depolymerization. The perpetual cycles of ParA assembly and disassembly result in continuous relocation of plasmids, which, on time averaging, results in equidistribution...

Application of the cubic-plus-association equation of state to mixtures with polar chemicals and high pressures

DEFF Research Database (Denmark)

Folas, Georgios; Kontogeorgis, Georgios; Michelsen, Michael Locht

2006-01-01

was given to low pressures and liquid-liquid equilibria. In this work, CPA is applied to two classes of mixtures containing polar chemicals for which high-pressure data are available: acetone-containing systems and dimethyl ether mixtures. They are of both scientific and industrial importance. Moreover, CPA......The cubic-plus-association (CPA) equation of state has been previously applied to vapor-liquid, liquid-liquid, and solid-liquid equilibria of mixtures containing associating compounds (water, alcohols, glycols, acids, amines). Although some high-pressure applications have been presented, emphasis...... to conventional models such as MHV2. Very good results are also obtained for multicomponent vapor-liquid-liquid equilibria for mixtures containing gases, water, and dimethyl ether. Finally, it is shown that high-pressure SLE can be predicted based on interaction parameters obtained from low-pressure SLE data....

Decoherence and Fidelity in Teleportation of Coherent Photon-Added Two-Mode Squeezed Thermal States

Science.gov (United States)

Li, Heng-Mei; Yuan, Hong-Chun; Wan, Zhi-Long; Wang, Zhen

2018-04-01

We theoretically introduce a kind of non-Gaussian entangled resources, i.e., coherent photon-added two-mode squeezed thermal states (CPA-TMSTS), by successively performing coherent photon addition operation to the two-mode squeezed thermal states. The normalization factor related to bivariate Hermite polynomials is obtained. Based upon it, the nonclassicality and decoherence process are analyzed by virtue of the Wigner function. It is shown that the coherent photon addition operation is an effective way in generating partial negative values of Wigner function, which clearly manifests the nonclassicality and non-Gaussianity of the target states. Additionally, the fidelity in teleporting coherent states using CPA-TMSTS as entangled resource is quantified both analytically and numerically. It is found that the CPA-TMSTS is an entangled resource of high-efficiency and high-fidelity in quantum teleportation.

Cerebellopontine angle and internal auditory canal: neurovascular anatomy on gas CT cisternograms

International Nuclear Information System (INIS)

Bird, C.R.; Hasso, A.N.; Drayer, B.P.; Hinshaw, D.B. Jr.; Thompson, J.R.

1985-01-01

The authors reviewed 103 normal gas CT cisternograms to delineate the appearance of normal neurovascular structures in the cerebellopontine angle (CPA) and internal auditory canal (IAC). Cranial nerves VII and VIII were identified in the CPA in 97% of cases, either separately (53%) or as a bundle (44%). Intracanalicular branches of the VIIIth cranial nerve were identified in 20% of cases, and cranial nerve V was visualized in the CPA in 14%. The characteristic vascular loop, usually the anterior inferior cerebellar artery, was visible in 35% of cases, and, in 22% of visualized cases, was in an intracanalicular location. In 10% of cases, greater than 66% of the IAC was occupied by the neurovascular bundle. Familiarity with the normal anatomy and variations seen on gas CT cisternograms is necessary to prevent false-positive interpretations

Contribuição para o estudo de sistemas de tratamento de água para abastecimento associados à remoção de compostos farmacêuticos

OpenAIRE

Cid, Joana Ferraz Leal de Sobral

2011-01-01

Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do grau de Mestre em Engenharia do Ambiente, perfil Engenharia Sanitária Este trabalho pretende contribuir para o estudo de sistemas de tratamento de água para abastecimento associados à remoção de compostos farmacêuticos. Assim, para melhor compreender a importância da remoção dos compostos farmacêuticos da água para abastecimento surge uma abordagem sobre a presença dos compostos...

EL SOL COMO ALTERNATIVA PARA PRODUCIR ENERGÍA ELÉCTRICA: PROPUESTA PARQUE INFANTIL PARA LA CIUDAD DE CÚCUTA

Directory of Open Access Journals (Sweden)

Karla Yohana Sánchez-Mojica

2015-06-01

Full Text Available La problemática del consumo descontrolado de energía eléctrica en el mundo y su constante crecimiento, es el escenario para el desarrollo de esta investigación que busca adelantar una propuesta para crear un parque infantil por parte de estudiantes de la Institución educativa Carlos Ramírez Paris, que funcione con energía solar como estrategia de sensibilización a la comunidad en general sobre el uso de energías limpias en la ciudad y en Colombia. Los estudiantes plantean la idea desde el programa ondas en una investigación que responde a una necesidad inmediata que los motiva como lo es un parque de diversiones público, sin embargo, es una alternativa para pensar en proyectos macro de desarrollo para la ciudad. Con esta propuesta se pretende diseñar una maqueta de un parque infantil a pequeña escala donde los estudiantes plasmen su iniciativa y se muestre la aplicación de la energía solar para el funcionamiento de algunos atractivos; una de los principales objetivos del proyecto es responder a la curiosidad de los estudiantes por saber cómo es el funcionamiento de este tipo de energía haciendo uso de los paneles solares.

El concepto de desarrollo y las propuestas de comunicación para el desarrollo: hojas de ruta de la comunicación para la paz

OpenAIRE

Sala Valdés, Cristina

2011-01-01

La comunicación para el desarrollo y la comunicación para la paz han evolucionado de forma paralela durante los últimos cuarenta años, siendo la comunicación para la paz un área menos explorada teóricamente y por tanto más asentada en la práctica. El repaso histórico y análisis de los paradigmas que han ido vertebrando tanto el concepto de desarrollo como el de comunicación para el desarrollo permiten descubrir cuáles son los ejes teóricos y prácticos que pueden orientar la comunicación para ...

Plan de Mercadeo para una “FinTech”.

OpenAIRE

Escalante Lee, Maria Alejandra

2016-01-01

Las empresas deben contar con una misión clara, estableciendo los objetivos de apoyo, diseñando una cartera de negocio sólida y coordinar sus estrategias a futuro, con el fin de cumplir las metas propuestas para entregar e intercambiar ofertas que tienen valor para los consumidores, clientes, socios y la sociedad en general. El presente trabajo de grado tiene como objetivo proponer un plan de mercadeo para la empresa Comyno una FinTech ubicada en Frankfurt am Main, en Alemania. Este tiene ...

Oxitocina: nuevas perspectivas para una droga antigua

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Steven L. CLARK

2010-12-01

Full Text Available La oxitocina es el medicamento más comúnmente asociada con la prevención de complicaciones perinatales y recientemente fue incluida por el Instituto para la Administración Medicamentosa Segura (Institute for Safe Medication Practices - ISMP en una pequeña lista de medicamentos “con alto grado de riesgos”, lo que puede “necesitar salvaguardas especiales para reducir el riesgo de error”. Las recomendaciones actuales para administrar este medicamento son vagas en relación a la indicación, tiempo de uso, dosis y el monitoreo de los efectos maternos y fetales. Una revisión de los datos clínicos y farmacológicos disponibles sugiere que las orientaciones específicas y basadas en evidencias para administrar oxitocina durante el parto puede derivarse de datos disponibles. Si implementadas, estas prácticas pueden reducir la probabilidad de daños al paciente. Esto sugiere el foco de las orientaciones para la administración electiva limitada de oxitocina, considerar estrategias que disminuyan la necesidad de usar oxitocina, confiar en terapéuticas de bajas dosis de oxitocina, la adhesión a definiciones semicuantitativas específicas sobre parto adecuado e inadecuado, y la aceptación de que, una vez que la actividad uterina adecuada sea alcanzada, es generalmente preferible esperar más tiempo que aumentar la infusión de oxitocina. El uso de protocolos conservadores y específicos para monitorear los efectos de la oxitocina en la madre y en el bebé tiende no sólo a aumentar los resultados, mas también a reducir los conflictos entre miembros del equipo obstétrico. Implementar estas orientaciones parece ser apropiada en una cultura cada vez más focalizada en la seguridad del paciente.

Estrategias de mercado para el frijol centroamericano

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Lourdes Mart\\u00EDnez

2004-01-01

Full Text Available Estrategias de mercado para el frijol centroamericano. En los últimos años, el sub-sector de frijol en Centro América ha sido testigo de varios cambios dinámicos. Si no se encuentran medidas para incrementar la competitividad regional de este sub-sector, los países centroamericanos experimentarán impactos negativos en las áreas sociales y económicas de considerable magnitud, especialmente ahora que Centro América necesita ajustar su economía a los nuevos requerimientos de mercados mas abiertos, como el Tratado Centroamericano de Libre Comercio con USA (TLC. Vendedores de frijoles a nivel intermediario y de consumo final, así como técnicos de oficinas gubernamentales dedicadas al mercadeo de frijoles en Centro América fueron entrevistados para documentar los cambios experimentados, identificar los obstáculos que frenan la viabilidad del sub-sector e identificar las oportunidades de incremento de mercados en el futuro para los productores y vendedores de frijol. Los resultados muestran que para que continúen siendo competitivos, los países centroamericanos deben incrementar la productividad a través del apoyo a las investigaciones para el mejoramiento de variedades de frijol, especialmente aquellas que los consumidores prefieren por características específicas (e.g. color. También es imprescindible el fortalecimiento de los programas de distribución de variedades mejoradas a los productores; las mejoras en la transmisión de información de mercado a los productores; el fortalecimiento de los contactos entre productores, comercializadores a nivel mayorista y supermercados; y una política más específica de apertura de mercados de exportación, especialmente con los Estados Unidos.

LOS DERECHOS HUMANOS EN AMÉRICA LATINA: POR QUÉ, PARA QUÉ Y PARA QUIÉN

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Carmen M. Rodríguez Salgado

2001-01-01

Full Text Available Los interrogantes por qué, para qué y para quién hacen que cobre vigencia la importancia de seguir luchando por el respeto y defensa de los Derechos Humanos en América Latina. En este artículo se examina la situación en la cual gobiernos supuestamente democráticos agreden de manera brutal a la población civil al imponer leyes que perdonan las violaciones pasadas, e implementan y promueven condiciones de vida en las que el 1/3 de la población latinoamericana vive debajo del límite de pobreza. Debemos analizar esto junto a la carencia total de algunos derechos básicos. La situación social de violencia económica-política, física y psicológica a la que cotidianamente están sometidos los argentinos, la desocupación estructural, las muertes evitables, no son episodios extraordinarios sino situaciones cotidianas. Lo anterior ejercita la continuidad del autoritarismo, la impunidad, la estigmatización y la discriminación. En el siglo XX los fascismos construyeron sobre la base del odio una comunidad para la muerte. El terror impuesto por la última dictadura militar en la Argentina se vuelve a vivir con un Estado que hace desaparecer a los ciudadanos de su lugar social. Los trabajadores de la salud, sostiene la autora de este artículo, deben participar activamente para generar políticas que permitan transformar esta sociedad, y reconoce la memoria como la forma de resistencia al olvido.

MÁS QUE TÁCTICAS PARA SOBREVIVIR

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ANA MARÍA ARBOLEDA ARANGO

2009-01-01

Full Text Available HOP es una empresa líder en suministros de oficina que enfrenta la problemática de contar con una gran variedad de eventos comerciales dirigidos a clientes de los diferentes canales. Permanentemente implementa nuevas tácticas para llegar al cliente y para estar notoriamente en el punto de venta. Sin embargo, la diversidad de actividades del canal está afectando su rentabilidad. Este comportamiento es sustentado por el departamento comercial como el único camino para ser competitivos. Además, la multiplicidad de actividades comerciales parece no estar jugando a favor sino en contra del cumplimento de los objetivos de venta. Con este marco, una serie de preguntas llevan al estudiante a pensar más allá de las tácticas con las que HOP reacciona en el día a día, para pasar a pensar en una estrategia comercial de largo plazo teniendo en cuenta un plan a tres años y una propuesta de evaluación y seguimiento.

AÇÕES EDUCATIVAS PARA TERCEIRA IDADE

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Rejane Millions Viana Meneses

2013-01-01

Full Text Available En el proceso del envejecimiento, anciano se enfrentan a la aparición de enfermedades crónicas que muchas veces reflejan en dificultades para el mantenimiento de la salud. En este contexto, es importante el trabajo con la tercera edad para promover la mejora del consiguiente estilo de vida. Este trabajo es un relato de experiencia de la ejecución de un proyecto de investigación de la Universidad Federal de Rio Grande do Norte , que lleva acciones educativas a la Asociación Inaraí (Natal/RN, con objetivo de divulgar actividades, así estimulando la formación de los grupos a que tienen como objetivo la promoción a salud de ancianos . Para desarrollar las acciones, según la informaciones recogidas en el perfil epidemiológico llevado previamente en la Asociación, por medio de reuniones semanales con anciano s, se buscó estimular buenos hábitos de vida , para llevar a cabo posible la mejora de lo estilo de vida y por lo tanto, promover salud de ese grupo.

The Regulation of para-Nitrophenol Degradation in Pseudomonas putida DLL-E4.

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Qiongzhen Chen

Full Text Available Pseudomonas putida DLL-E4 can efficiently degrade para-nitrophenol and its intermediate metabolite hydroquinone. The regulation of para-nitrophenol degradation was studied, and PNP induced a global change in the transcriptome of P. putida DLL-E4. When grown on PNP, the wild-type strain exhibited significant downregulation of 2912 genes and upregulation of 845 genes, whereas 2927 genes were downregulated and 891 genes upregulated in a pnpR-deleted strain. Genes related to two non-coding RNAs (ins1 and ins2, para-nitrophenol metabolism, the tricarboxylic acid cycle, the outer membrane porin OprB, glucose dehydrogenase Gcd, and carbon catabolite repression were significantly upregulated when cells were grown on para-nitrophenol plus glucose. pnpA, pnpR, pnpC1C2DECX1X2, and pnpR1 are key genes in para-nitrophenol degradation, whereas pnpAb and pnpC1bC2bDbEbCbX1bX2b have lost the ability to degrade para-nitrophenol. Multiple components including transcriptional regulators and other unknown factors regulate para-nitrophenol degradation, and the transcriptional regulation of para-nitrophenol degradation is complex. Glucose utilization was enhanced at early stages of para-nitrophenol supplementation. However, it was inhibited after the total consumption of para-nitrophenol. The addition of glucose led to a significant enhancement in para-nitrophenol degradation and up-regulation in the expression of genes involved in para-nitrophenol degradation and carbon catabolite repression (CCR. It seemed that para-nitrophenol degradation can be regulated by CCR, and relief of CCR might contribute to enhanced para-nitrophenol degradation. In brief, the regulation of para-nitrophenol degradation seems to be controlled by multiple factors and requires further study.

UMA METODOLOGIA VOLTADA PARA O DESENVOLVIMENTO DE LÍDERES

OpenAIRE

Carvalho, Leila de Moura

2003-01-01

Este trabalho aborda uma metodologia voltada para o desenvolvimento do grupo de líderes da Divisão Logística de uma empresa do setor de varejo. Em uma pesquisa realizada pela empresa, detectou-se uma deficiência no estilo de supervisão atual adotada pelo grupo de líderes e as conseqüências negativas geradas para a organização. A proposta deste trabalho é promover a educação e o treinamento do grupo de líderes para uma mudança de estilo de supervisão. Para isso, propõe-se a utilizar como base ...

APUNTES PARA EL DESARROLLO DE INTERVENCIONES DE PREVENCIÓN DE VIH/ITS PARA JÓVENES EN PUERTO RICO

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Patricia L. Noboa-Ortega

2017-01-01

Full Text Available En este artículo presentamos los resultados de la implantación de tres grupos focales utilizados para adaptar una intervención para la prevención del VIH/ITS en jóvenes. Uno de los grupos fue celebrado con hombres, uno con mujeres, y otro con parejas donde participaron un total de 27 personas . Auscultamos el conocimiento sobre el VIH/ITS, las situaciones que los exponen a riesgo, el formato y contenido que una intervención debía ten er. Encontramos que aunque los y las jóvenes tenían un conocimiento básico, también tenían concepciones equivocadas como que el VIH/ITS se transmite por el beso y la saliva, y que la Clamidia se transmite por sentarse en inodoros públicos. Expresaron que una intervención debe abordar las diversas dificultades que los y las jóvenes enfrentan para el uso del condón y que debe utilizar testimonios reales de personas. El uso de grupos focales es una herramienta muy útil para identificar el formato y contenid o de intervenciones. .

Criterios para una acompañamiento familiar integral, con orientación personalista, para instituciones educativas

OpenAIRE

Marroquín Valdiviezo, Carmen Isabel del Pilar

2016-01-01

Frente a la crisis familiar que vivimos actualmente, la presente investigación cualitativa buscó proponer los criterios para un acompañamiento familiar integral, con orientación personalista, para instituciones educativas. En un primer momento, hemos identificado las bases teóricas: las perspectivas de la persona desde el personalismo y las teorías psicológicas sobre las familias. Dichas bases nos han permitido conocer diversas posturas en torno a la persona y su vínculo familiar. Además, se ...

Libertad religiosa, camino para la paz

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Antonio Alonso

2011-01-01

Full Text Available La libertad religiosa es el núcleo del Mensaje para la XLIV Jornada Mundial de la Paz que ha dirigido Benedicto XVI. Cuestión, sin duda, extraordinariamente delicada, pues comporta graves implicaciones en materia de seguridad principalmente por dos motivos: primero, porque su violación supone una injusticia difícil de compaginar con el respeto a los Derechos Humanos; segundo, porque dicha libertad no puede ser esgrimida como pretexto para atropellar los derechos de los demás conciudadanos o incluso socavar la propia seguridad del Estado. El Santo Padre denuncia, a su vez, los estragos del relativismo y de los fanatismos, tanto religioso como anti-religioso, y propone el ejercicio del diálogo basado en la razón para superar los obstáculos en la convivencia interpuestos por estas amenazas a la paz y la seguridad.

Programa de conservacion para aves migratorias neotropicales

Science.gov (United States)

Deborah Finch; Marcia Wilson; Roberto Roca

1992-01-01

Mas de 250 especies de aves terrestres migran a Norte America durante la epoca reproductiva para aprovechar los sistemas templados. No obstante, las aves migratorias neotropicales pasan la mayor parte de su ciclo de vida en los habitat tropicales y subtropicales de paises latinoamericanos y caribefios donde viven en una asociacion cercana con las aves residentes. Para...

Kaatsu training : novas perspectivas para o treinamento resistido

OpenAIRE

Deus, Lysleine Alves de

2012-01-01

Para que um treinamento resistido possa contribuir de forma eficaz para o aumento de força e hipertrofia, muitos são os fatores que interferem na sua elaboração. Estudos ao longo dos anos vinham relatando que o treinamento resistido executado com cargas altas era o método mais eficaz para o aumento de força e hipertrofia. Em contradição a essas teorias pesquisadores japoneses desenvolveram uma nova técnica em que o treinamento resistido (TR) é executado com baixa intensidade e pouco peso asso...

HERRAMIENTAS PARA LA ESTIMACIÓN DEL RIESGO CARDIOVASCULAR

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Dra. Sonia Kunstmann

2018-01-01

Existen diferentes herramientas para medir el riesgo cardiovascular, siendo las tablas de estratificación las más utilizadas para estos fines. Existen marcadores de riesgo que añaden poco a la estratificación y se recomiendan solo en evaluaciones del especialista. Algunas imágenes como Score de Calcio, son una nueva herramienta de evaluación del riesgo de presentar un evento cardiovascular en los próximos años. Esta revisión analiza diversas herramientas para la prevención cardiovascular

Pedagogía de la memoria y educación para el "nunca más" para la construcción de la democracia

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Susana Sacavino

2015-01-01

Full Text Available La educación en derechos humanos es una mediación importante para la afirmación y la construcción de la democracia. En Brasil, en 2014, se cumplieron cincuenta años del golpe civil-militar que dio inicio a una larga dictadura de más de dos décadas, con prácticas sistemáticas de violación de los derechos humanos por parte del Estado. En este contexto es de fundamental importancia desarrollar una pedagogía de la memoria para educar para el nunca más en la línea de la cualificación y mejoramiento de la democracia. Desde un enfoque de (desconmemoración del cincuentenario de la dictadura civil-militar, este artículo se estructura en tres partes. En la primera, se presenta el origen de la expresión nunca más, su incorporación en la educación en derechos humanos y su relación con la memoria. Se profundiza también en diferentes sentidos de la memoria y sus contribuciones y articulaciones para la educación para el nunca más. Por último, se argumenta sobre por qué educar para el nunca más. En la segunda parte se presentan tres propuestas pedagógicas desde una óptica de (desconmemoración de los cincuenta años de la dictadura civil-militar para educar para el nunca más: una propuesta de carácter general, otra orientada a la formación de los docentes, y la tercera, para que el maestro pueda trabajar con sus alumnos en el aula de clase. Luego, se tejen algunas consideraciones sobre el tema del trabajo de la(s memoria(s y la educación para el nunca más.

AS CONSTANTES BARREIRAS ENFRENTADAS PARA ESCOLHA DO TEMA DE TCC

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Gabriel Aparecido Zucoloto

2016-11-01

Full Text Available O presente artigo busca analisar quais são as principais dificuldades encontradas na escolha de um tema para Trabalho de Conclusão de Curso - TCC. Para resolver este problema de pesquisa, foi necessário levantar as principais dificuldades encontradas por alunos na hora de escolher o tema do TCC. Para tanto, foi aplicado um questionário eletrônico, via Google Docs, como método de coleta de dados, cujo resultado fora tabulado e apontado um resultado estatístico para a pesquisa. O público-alvo da pesquisa foram 130 alunos do curso superior de análise de sistema de uma instituição de ensino público. Com o resultado encontrado a partir dos questionários, nota-se dificuldades como o a inexperiência das normas a serem seguidas para formatação de projetos, além do pouco conhecimento sobre o tema que gostariam de abordar, pode-se apurar que a escolha para um tema pode ser muito difícil levando-se em consideração fatores como conhecimento adquirido durante o curso e tempo para se dedicar ao trabalho.

Development of a Collaborative Practice Agreement Template to Promote the Role of the Pharmacist in Managing Urinary Tract Infections in Long-term Care Residents

OpenAIRE

Fehrenbacher, Lynne; McDevitt, Kimberly; Palmer, Matthew; Traynor, Laura; Boero, Joe; Crnich, Christopher

2017-01-01

Abstract Background One of the CDC core elements of antimicrobial stewardship in nursing homes emphasizes the promotion of clinical practice change and integration of the dispensing and consultant pharmacist to improve antibiotic use. An opportunity to support this element is via collaborative practice agreements (CPA). A CPA is a voluntary agreement between one or more prescribers and pharmacists which delegates physician authority under defined conditions and/or limitations toward a common ...

Para hydrogen equilibration in the atmospheres of the outer planets

International Nuclear Information System (INIS)

Conrath, B.J.

1986-01-01

The thermodynamic behavior of the atmospheres of the Jovian planets is strongly dependent on the extent to which local thermal equilibration of the ortho and para states of molecular hydrogen is achieved. Voyager IRIS data from Jupiter imply substantial departures of the para hydrogen fraction from equilibrium in the upper troposphere at low latitudes, but with values approaching equilibrium at higher latitudes. Data from Saturn are less sensitive to the orth-para ratio, but suggest para hydrogen fractions near the equilibrium value. Above approximately the 200 K temperature level, para hydrogen conversion can enhance the efficiency of convection, resulting in a substantial increase in overturning times on all of the outer planets. Currently available data cannot definitively establish the ortho-para ratios in the atmospheres of Uranus and Neptune, but suggest values closer to local equilibrium than to the 3.1 normal ratio. Modeling of sub-millimeter wavelength measurements of these planets suggest thermal structures with frozen equilibrium lapse rates in their convective regions

FOTOBIORREACTOR: HERRAMIENTA PARA CULTIVO DE CIANOBACTERIAS

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Luis Guillermo Ramírez Mérida

2014-05-01

Full Text Available Las cianobactérias son organismos eficientes en la conversión de energía solar y producen una gran variedad de metabolitos. En la actualidad son el centro de atención para la producción de biocombustible, son usadas como biofertilizantes, control de contaminación ambiental y como fuente de nutrientes en alimentación humana y animal. Con el fin de proporcionar crecimiento y aprovechar el potencial de las cianobacterias, se requieren fotobiorreactores eficientes. Aunque se han propuesto muchos tipos de fotobiorreactores, no existe un reactor ideal, solo unos pocos pueden utilizarse para la producción de biomasa de cianobacterias. De hecho, la elección del fotobiorreactor más adecuado depende de la situación, ya que tanto las especies de algas disponibles y el destino final jugarán un papel importante. Uno de los principales factores que limita su aplicación práctica en cultivos de biomasa es la transferencia de masa. Por esto, entender el coeficiente de transferencia de masa en los fotobiorreactores es necesario para una operación eficiente del cultivo de biomasa en cianobacterias. En esta revisión, se discuten varios tipos de fotobiorreactores muy promisorios para la producción de biomasa de cianobacterias.

para asegurar un hijo sano

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Carmen Amarilis Guerra de Castillo

2006-01-01

Full Text Available Esta investigación etnográfica focalizada exploró las creencias, los valores, los hábitos y los padrones comportamentales de las embarazadas diabéticas atendidas en el Hospital Doctor Enrique Tejera, quienes residen en tres comunidades urbanas pobres de la ciudad de Valencia - Venezuela, con el objetivo de encontrar el significado del cuidado de si para dichas grávidas. Se utilizó como referencial teórico el Modelo del Análisis de la Salud y la Teoría Antropológica de la Salud, siendo fundamentales para revelar aquello que estaba implícito en el comportamiento de las mujeres con relación a su cuidado. Surgieron tres temas: la salud y la enfermedad - valores culturales del cuidado de si; las prácticas del cuidado de la salud y cuidándose en el embarazo garantiza tener un hijo más saludable. Los temas culturales revelaron que las creencias, los valores, los hábitos y los patrones culturales comportamentales, conforme las tres maneras de acción identificadas, pueden ser preservadas, acomodadas y re-estructuradas para proporcionar un cuidado culturalmente congruente.

Condiciones para el aprendizaje organizacional

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Delio Ignacio Castañeda

2015-01-01

Full Text Available El propósito de esta investigación es contribuir al entendimiento de algunas condiciones que favorecen el aprendizaje en las organizaciones, específicamente el rol de la cultura del aprendizaje, la formación, la claridad estratégica y el soporte organizacional. Se emplea una metodología cuantitativa con 613 participantes, empleados de una organización pública y 2 compañías privadas, las 3 entidades ubicadas en Bogotá, Colombia. Para la realización del estudio se conformó una muestra por conveniencia, con el apoyo de los jefes de recursos humanos de 3 organizaciones con sede en la ciudad de Bogotá, Colombia. Para la recolección de los datos se utilizó una escala Likert de 5 niveles de respuesta. Los resultados sugieren que las 4 condiciones estudiadas contribuyen al aprendizaje organizacional. Los hallazgos de este trabajo orientan a profesionales sobre dónde focalizar esfuerzos para promover la adquisición y la generación de conocimiento organizacional y aporta al trabajo investigativo ampliando la evidencia empírica sobre este campo de relevancia organizacional.

Condiciones para el aprendizaje organizacional

Directory of Open Access Journals (Sweden)

Delio Ignacio Castañeda

2015-01-01

Full Text Available El propósito de esta investigación es contribuir al entendimiento de algunas condiciones que favorecen el aprendizaje en las organizaciones, específicamente el rol de la cultura del aprendizaje, la formación, la claridad estratégica y el soporte organizacional. Se emplea una metodología cuantitativa con 613 participantes, empleados de una organización pública y 2 compa˜nías privadas, las 3 entidades ubicadas en Bogotá, Colombia. Para la realización del estudio se conformó una muestra por conveniencia, con el apoyo de los jefes de recursos humanos de 3 organizaciones con sede en la ciudad de Bogotá, Colombia. Para la recolección de los datos se utilizó una escala Likert de 5 niveles de respuesta. Los resultados sugieren que las 4 condiciones estudiadas contribuyen al aprendizaje organizacional. Los hallazgos de este trabajo orientan a profesionales sobre dónde focalizar esfuerzos para promover la adquisición y la generación de conocimiento organizacional y aporta al trabajo investigativo ampliando la evidencia empírica sobre este campo de relevancia organizacional.

Plan de marketing para un vivero de planta ornamental

OpenAIRE

MARCH CUBERTORET, PAULA

2017-01-01

[ES] Se ha realizado un plan de marketing de un vivero de planta ornamental interior en Petrés (Valencia), así como un estudio de mercado para analizar las necesidades del consumidor y proponer mejorar el posicionamiento de la empresa para finalmente aumentar las ventas de sus productos. March Cubertoret, P. (2017). Plan de marketing para un vivero de planta ornamental. http://hdl.handle.net/10251/92819 TFGM

Propuesta para un plan de marketing para el Hotel Haro ubicado en la ciudad de Cuenca

OpenAIRE

López Zúniga, Susana Cristina; Yanza Barrera, Mariana de Jesús

2008-01-01

El plan de marketing es una herramienta de gestión que sirve de base para los otros planes de la empresa como puede ser el plan de producción o el financiero, determina responsabilidades, permite revisiones y controles periódicos para resolver los problemas con anticipación, evitar pérdidas económicas y ayuda a la empresa a estar lista frente a los riegos y oportunidades que se presenten en el mercado. En el espacio donde el mercado se convierte cada vez más competitivo hay menos posibilid...

Residencias estudiantiles universitarias, una oportunidad para la equidad y la educación para la salud

OpenAIRE

Vargas Benavides, D.; Avendaño Salas, M.

2017-01-01

Introducción: Desde el año 2000 se han realizado actividades para promover en la población de estudiantes, conductas de vida saludables, en el 2016 se reestructura el programa y se define: Promover el liderazgo estudiantil de la población residente, mediante el desarrollo de estrategias que favorezcan la equidad y la educación en salud, para contribuir al desarrollo de conductas saludables. Material y método: El Programa de Residencias estudiantiles de la UNA, atiende un total de 256 estudian...

Colombia competente para la paz

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Norma Sofía Vanegas Torres

2013-07-01

Full Text Available La paz y la convivencia en Colombia demandan el desarrollo de un enfoque humanístico, una competencia particular que como las restantes competencias implican un saber y un saber hacer dentro de un contexto, pero que en este caso se relacionan más concretamente con el saber vivir. Este artículo analiza el desarrollo de una posible de competencia para la paz y analiza la importancia de la academia como medio para su desarrollo e instrumentalización. Se analizan al mismo tiempo las connotaciones de esta competencia en el marco de la sociedad posmoderna contemporánea.

Compilador para lenguaje basado en continuaciones

OpenAIRE

Ramos Carreño, Carlos

2015-01-01

Las continuaciones son una construcción de algunos lenguajes de programación a partir de las cuales pueden elaborarse elementos más complejos, como fibras, generadores, excepciones y corrutinas. Sin embargo, hay poco soporte nativo para ellas en los lenguajes más populares, como por ejemplo Java. En este trabajo se estudia este concepto en profundidad, centrándonos en las llamadas “continuaciones delimitadas”. Para ello se ha implementado un lenguaje de bajo nivel con soport...

Augusto Boal: teatro para a transformação

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Irene Leonore Goldschmidt

2012-05-01

Full Text Available Embora o uso do teatro para mediar e enriquecer processos educacionais não seja uma ideia nova, a forma como é desenvolvido pode servir para a reprodução ou para a transformação da sociedade. O teatrólogo Augusto Boal desenvolveu uma metodologia, à qual denominou de Teatro do Oprimido, para, através da linguagem teatral promover autonomia e capacidade crítica, tornando o espectador em ator. Na sua última obra, editada em 2009, A Estética do Oprimido, levanta uma importante questão contemporânea sobre o papel da estética e suas relações com o poder.

Un almuerzo para llevar saludable (Packing Smart)

Centers for Disease Control (CDC) Podcasts

2011-08-22

En este podcast para niños, los chicos de Kidtastics hablan sobre almuerzos creativos para llevarse a la escuela, que ayuden a mantenerse con energía el resto del día.  Created: 8/22/2011 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 1/3/2012.

EL POLVO DE COCO COMO SUSTRATO ALTERNATIVO PARA LA OBTENCIÓN DE PLANTAS ORNAMENTALES PARA TRASPLANTE

Directory of Open Access Journals (Sweden)

A. Ayala-Sierra

2008-01-01

Full Text Available La presente investigación se realizó con el objeto de evaluar la factibilidad de utilizar sustratos elaborados a base de polvo de coco para la germinación de semillas y desarrollo inicial de plantas para trasplante de seis especies ornamentales y determinar la posibilidad de remplazar al Peat Moss. Las especies seleccionadas para el estudio fueron: Dianthus chinensis (clavelina, Gazania rigens (gazania, Tagetes erecta (marigold, Viola wittrockiana (pensamiento, Antirrhinum majus (dragón y Petunia x hybrida (petunia. Las semillas de las seis especies fueron sembradas en tres sustratos: polvo de coco, Peat Moss y Peat Lite. Previo a la siembra, el polvo de coco fue acondicionado mediante el ajuste del pH a 6.2, la adición de cal dolomítica y KNO3 como carga de nutrientes. Posteriormente, se elaboró una mezcla a base de polvo de coco, perlita y vermiculita a razón de 70, 20 y 10 % (v/v, y Peat Moss, perlita y vermiculita en las mismas proporciones. El Peat Lite contenía 50 % de Peat Moss y 50 % de perlita (v/v. Se evaluó el efecto de los sustratos en la altura de planta, el peso seco del vástago y de raíz, el porcentaje de germinación y el porcentaje de plantas con valor comercial. Aunque el polvo de coco causó una disminución significativa en la altura de plantas de gazania (21 %, dragones (30 % y petunias (13 %, y en el peso seco del vástago de dragones (24 % y en el peso seco de raíz de clavelina (22 %, esto no estuvo asociado con una disminución en la calidad de las plantas. Por lo tanto, se concluye que el polvo de coco puede utilizarse como sustrato para la producción de plantas para trasplante de especies ornamentales.

Producción de microorganismos probióticos como aditivo para alimentos concentrados para ganado vacuno.

Directory of Open Access Journals (Sweden)

Edgar Mauricio Vargas.

2004-11-01

Full Text Available Por años, las industrias y los laboratorios de investigación han buscado las aplicaciones de los organismos probióticos en animales. El uso de los probióticos como alternativa natural para mejorar el funcionamiento del metabolismo animal; ha demostrado resultados muy interesantes. Modernas granjas utilizan dietas alimenticias (a base probióticos que disminuyen el estrés, aumentan la microflora intestinal, lo que conlleva al animal a aumentar su resistencia a las infecciones (sistema inmunológico. Mejorar la salud animal, rendimiento en peso y funcionamiento metabólico, ha sido siempre la meta para los productores de ganado de carne y leche. Por esta razón el actual estudio fue concebido para evaluar el microencapsulamiento de microorganismos prebióticos (Lactobacillus Thuringenesis y Bifidobacterium Pseudulongum por los métodos de Emulsión y Extrusión. para obtener un alimento para levante de becerros, que ofrecería no solamente las ventajas de un suplemento de la alta calidad, sino también un producto con las ventajas de tener probióticos incorporados. / For years, industries and research labs have investigated probiotics for nonhuman applications. The use of probiotics as an alternative natural way of enhancing animal performance has shown promising results. Modern farm methods which include rearing conditions and diets induce stress and cause changes in the composition of the microflora, which compromises the animal's resistance to infection. The aim of the probiotic approach is to repair the deficiencies in the microflora and restore the animal's resistance to disease. Improving animal health and performance has always been the goal for farm and livestock producers. For this reason the present study was conducted to develop the microencapsulation of Probiotics (Lactobacillus Thuringenesis and Bifidobacterium Pseudulongum by the methods of Emulsion and Extrusion, to obtain a daily diet for calves that could offer not only the

Consentimiento Informado para Biobancos: Un debate ético abierto

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Norma Serrano-Díaz

2016-06-01

Full Text Available Los Biobancos con fines de Investigación están aumentando en número e importancia, con un gran potencial que contribuye a la generación de conocimiento pertinente para la solución de problemas en salud. El reclutamiento de donantes es vital para su éxito. Sin embargo, este proceso tiene implicaciones importantes de carácter ético, legal y social. El consentimiento informado requerido para la participación del donante impone desafíos éticos importantes en torno a la privacidad, confidencialidad, uso secundario de muestras y datos para estudios futuros, retorno de resultados, intercambio de datos, distribución de beneficios entre otras. Diferentes modelos de consentimiento informado han sido propuestos para responder a algunos de estos retos éticos . Sin embargo, no se ha llegado a un acuerdo, por lo tanto la discusión continúa abierta. Este trabajo pretende contribuir con la discusión, considerando fundamental el significado y el valor del proceso de consentimiento informado para la participación en investigación biomédica. Se discuten los diferentes tipos de consentimiento que se están utilizando actualmente evaluando el nivel de control y autodeterminación por parte del donante.

Escalas de depresión y ansiedad para personas transexuales

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José Miguel Rodríguez Molina

2015-01-01

Full Text Available La transexualidad es un fenómeno emergente. Es necesario evaluar no solo la presencia de transexualidad sino también todas las variables de proceso. Este estudio tuvo como objetivo presentar y analizar las propiedades psicométricas de dos instrumentos de evaluación en población transexual; uno para evaluar ansiedad y otro depresión. Se llevó a cabo la construcción cualitativa de las dos escalas y se validó su contenido mediante su aplicación a 154 sujetos. Se calcularon la validez de criterio y la fiabilidad mediante el Alfa de Cronbach y se ejecutó un Análisis Factorial Exploratorio. Se obtuvieron datos de alta significación estadística para la fiabilidad de las escalas (para ESANTRA un Alfa de Cronbach de .958 y correlación entre mitades de .926 y para ESDETRA un Alfa de Cronbach de .967 y correlación entre mitades de .958 y también para todos los elementos de ambas, así como una alta validez de criterio (para ESANTRA de .782 con p< .001 con el ISRA y para ESDETRA .829 con p< .001 con el BDI. El AFE mostró un único factor explicativo en cada escala (con varianza explicada del 45.71% ESANTRA y 51.55% ESDETRA. Las escalas ESANTRA y ESDETRA parecen ser útiles para la evaluación de ansiedad y depresión en personas transexuales.

Evaluación distintas metodologías para la preservación de Clostridium tetani, empleado en la producción de vacunas para uso humano.

Directory of Open Access Journals (Sweden)

Elsie Iglesias

2000-03-01

Full Text Available En el presente estudio se evaluaron diferentes metodologías para la preservación de Clostridium tetani. Para verificar el sustento del cultivo se realizó un adecuado control de calidad, que incluyó comprobación de pureza, viabilidad y estabilidad de las propiedades de interés. En este trabajo se compararon dos procedimientos para liofilizar y se evaluó el método de congelación a –20 0C para preservar C. tetani. Para medir determinados parámetros se realizaron procesos a escala industrial, empleándose para esto un Biorreactor Chemap de 35 L. Con este trabajo se buscó Alternativas y soluciones a problemas presentados en su conservación. Los resultados obtenidos sugieren la posible inclusión en el Programa de Mantenimiento establecido

Cuestionarios Interactivos para Autoevaluación

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Sánchez García, Juan Francisco

2007-01-01

Full Text Available La autoevaluación es un instrumento valioso para que el propio alumno pueda medir el grado de conocimientos adquiridos de la materia en cuestión, al tiempo sirve para adiestrarlo en el tipo de prueba que se utilizará posteriormente en el examen. Por otro lado, dado que en la adaptación al Espacio Europeo de Educación Superior (E3S tiene particular importancia la labor realizada por el propio alumno, los pruebas de autoevalución adquieren, si cabe, una mayor relevancia. Por todo ello, hemos elaborado unos test interactivos con hoja de calculo, para cubrir el doble propósito de evaluar los conocimientos alcanzados por nuestros alumnos, relativos tanto a la materia, como al manejo en sí de la propia herramienta informática de la hoja de cálculo. Se muestran ejemplos concretos relacionados con las matemáticas y la hoja de cálculo Excel.

El sistema de trabajo metodológico para las disciplinas que conforman las carreras en la SUM. Una estrategia para San Luis

Directory of Open Access Journals (Sweden)

Tania Alina Mena Silva

2009-09-01

Full Text Available La Globalización Neoliberal, la caída del Campo Socialista y los intentos de los Estados Unidos de adjudicarse el liderazgo internacional como protector de un mundo unipolar, han ejercido una gran influencia en el contexto sociopolítico latinoamericano actual al que la educación superior y las ciencias que se relacionan con su estudio no han estado ajenas. El propio perfeccionamiento que ha tenido lugar en la Educación Superior en Cuba ha obligado a redimensionar el trabajo metodológico de las disciplinas para poder lograr que se interactúe de forma tal, que se pueda aplicar el modelo de formación del profesional que se requiere en las condiciones de la Universalización. Para lo que se han reconsiderado los conceptos, las formas y las vías para las disciplinas de la SUM. Este trabajo persigue el objetivo de fundamentar teóricamente un sistema para el proceso de trabajo metodológico de las disciplinas en la SUM, de tal manera que permita elaborar el diseño de una Estrategia, para la gestión del proceso docente educativo en las condiciones de semipresencialidad y lograr que este sea, íntegro, sistémico y eficiente, pero flexible y centrado en el estudiante, teniendo en cuenta sus peculiaridades y las de los docentes así como el medio social donde se están formando, para lo que se necesita estar bien identificado con el proceso de transformación y adecuación, para poder implementar estos fundamentos en las disciplinas que conforman las carreras de la SUM.

Por y para en los manuales de ELE

Directory of Open Access Journals (Sweden)

Sidoti, Rossana

2008-12-01

Full Text Available La oposición por / para es una de las cuestiones gramaticales que comportan mayor dificultad a la hora de acercarse al estudio del español como L2 sobre todo cuando remiten a conceptos lingüísticos difíciles de entender por no tener ésta referente alguno en el mundo extralingüístico. Si, por un lado, nos resulta fácil entender lo que tiene un referente en el mundo concreto; por otro, no podemos advertir el referente extralingüístico de preposiciones como por / para, si este no existe. Si las preposiciones son elementos abstractos, difíciles de aferrar de por sí, podemos sólo examinar los elementos que éstas ponen en relación y en qué contextos esta relación se determina. Para poder utilizar con precisión las dos preposiciones, es importante no reducirlas a una sola preposición como ocurre en otros idiomas, y sobre todo no relacionarlas sólo a los conceptos de causa y finalidad. Este trabajo se propone individualizar los manuales de español como lengua extranjera más utilizados en las universidades italianas para luego comparar las distintas fuentes de información sobre por / para y exponer comentarios, reflexiones y sugerencias sobre el tema con el fin de precisar en qué medida se puede mejorar lo que los manuales reducen o generalizan, puesto que para los estudiantes de ELE estos representan una herramienta valiosa a la que acudir.

Inmunopotenciadores para la acuicultura

Directory of Open Access Journals (Sweden)

Rocmira Pérez

2014-04-01

Full Text Available La acuicultura es una de las actividades económicas de mayor crecimiento para la producción de alimentos. Uno de sus principales retos es la obtención de grandes volúmenes de producción con la mayor calidad posible. Esto conlleva a una reducción de la aplicación de antibióticos y productos quimioterapéuticos. Una de las estrategias más prometedoras es la aplicación de inmunopotenciadores, principalmente en los cultivos intensivos. El objetivo de este trabajo fue revisar los principales inmunopotenciadores, así como las tendencias y retos de su uso mundial. Se resumen las particularidades moleculares y funcionales de los mismos y se hace énfasis en los más estudiados: levamisol, ß-glucanos, lipopolisacárido, vitamina C, extractos de plantas y hormonas. Todos estos compuestos de naturaleza heterogénea inciden mayoritariamente en los componentes de la inmunidad innata de los peces, fortaleciendo y potenciando la resistencia a enfermedades; adicionalmente algunos de ellos tienen funciones antiestrés y favorecen su crecimiento. Se concluye que los inmunopotenciadores constituyen una estrategia viable para reducir las pérdidas por problemas sanitarios en el sector de la acuicultura; pero aún quedan por solucionar aspectos como la vía de administración y la etapa de inmunización adecuada para cada especie y tipo de cultivo.

Application of change-point analysis to determine winter sleep patterns of the raccoon dog (Nyctereutes procyonoides) from body temperature recordings and a multi-faceted dietary and behavioral study of wintering

Science.gov (United States)

2012-01-01

Background A multi-faceted approach was used to investigate the wintertime ecophysiology and behavioral patterns of the raccoon dog, Nyctereutes procyonoides, a suitable model for winter sleep studies. By utilizing GPS tracking, activity sensors, body temperature (Tb) recordings, change-point analysis (CPA), home range, habitat and dietary analyses, as well as fatty acid signatures (FAS), the impact of the species on wintertime food webs was assessed. The timing of passive bouts was determined with multiple methods and compared to Tb data analyzed by CPA. Results Raccoon dogs displayed wintertime mobility, and the home range sizes determined by GPS were similar or larger than previous estimates by radio tracking. The preferred habitats were gardens, shores, deciduous forests, and sparsely forested areas. Fields had close to neutral preference; roads and railroads were utilized as travel routes. Raccoon dogs participated actively in the food web and gained benefit from human activity. Mammals, plants, birds, and discarded fish comprised the most important dietary classes, and the consumption of fish could be detected in FAS. Ambient temperature was an important external factor influencing Tb and activity. The timing of passive periods approximated by behavioral data and by CPA shared 91% similarity. Conclusions Passive periods can be determined with CPA from Tb recordings without the previously used time-consuming and expensive methods. It would be possible to recruit more animals by using the simple methods of data loggers and ear tags. Hunting could be used as a tool to return the ear-tagged individuals allowing the economical extension of follow-up studies. The Tb and CPA methods could be applied to other northern carnivores. PMID:23237274

Awareness about medico legal aspects and Consumer Protection Act among dentists.

Science.gov (United States)

Radhika, T; Nadeem, J; Arthi, R; Nithya, S

2017-07-01

The practice of medicine in India has undergone considerable change affecting delivery of health in both positive and negative directions. As a result, there was a growing feeling that medical treatment should be made accountable and this led to doctors and dentists becoming subject to the process of law. Patients have become more aware of their right to compensation and as a consequence doctors and dentists should be knowledgeable about the laws that govern them. To assess the awareness about Medico legal aspects and Consumer Protection Act [CPA] among Dental professionals. A self-structured validated questionnaire comprising of 20 questions related to medico legal aspects and CPA was designed. A total of 450 dental professionals were surveyed from 4 prime dental institutions in Chennai, India. Of the 450 professionals that were surveyed 150 were MDS faculty, 150 were BDS faculty and 150 were PG students. The data was subjected to SPSS, version 16 and statistically analysed using Chi square test and Fisher's exact test. A- p value less than 0.05 was considered to be statistically significant. BDS faculty, MDS faculty and PG students were found to possess similar level of understanding and there was no significant difference between the groups. Knowledge was found to be equal between male and female dentists. The young practitioners were found to be more informed about CPA than the senior practitioners. It was found that most of the participants were aware of relevant Medico legal aspects, but were less aware of CPA. This study emphasises the need for education relevant to Medico legal aspects and CPA for dental professionals.

Molecular Regulation of Alternative Polyadenylation (APA) within the Drosophila Nervous System.

Science.gov (United States)

Vallejos Baier, Raul; Picao-Osorio, Joao; Alonso, Claudio R

2017-10-27

Alternative polyadenylation (APA) is a widespread gene regulatory mechanism that generates mRNAs with different 3'-ends, allowing them to interact with different sets of RNA regulators such as microRNAs and RNA-binding proteins. Recent studies have shown that during development, neural tissues produce mRNAs with particularly long 3'UTRs, suggesting that such extensions might be important for neural development and function. Despite this, the mechanisms underlying neural APA are not well understood. Here, we investigate this problem within the Drosophila nervous system, focusing on the roles played by general cleavage and polyadenylation factors (CPA factors). In particular, we examine the model that modulations in CPA factor concentration may affect APA during development. For this, we first analyse the expression of the Drosophila orthologues of all mammalian CPA factors and note that their expression decreases during embryogenesis. In contrast to this global developmental decrease in CPA factor expression, we see that cleavage factor I (CFI) expression is actually elevated in the late embryonic central nervous system, suggesting that CFI might play a special role in neural tissues. To test this, we use the UAS/Gal4 system to deplete CFI proteins from neural tissue and observe that in this condition, multiple genes switch their APA patterns, demonstrating a role of CFI in APA control during Drosophila neural development. Furthermore, analysis of genes with 3'UTR extensions of different length leads us to suggest a novel relation between 3'UTR length and sensitivity to CPA factor expression. Our work thus contributes to the understanding of the mechanisms of APA control within the developing central nervous system. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats.

Science.gov (United States)

Yan, Ni; Cao, Bing; Xu, Jiahe; Hao, Chun; Zhang, Xu; Li, Ying

2012-01-01

Studies of both humans and animals suggest that anterior cingulate cortex (ACC) is important for processing pain perception. We identified that perigenul ACC (pACC) sensitization and enhanced visceral pain in a visceral hypersensitive rat in previous studies. Pain contains both sensory and affective dimensions. Teasing apart the mechanisms that control the neural pathways mediating pain affect and sensation in nociceptive behavioral response is a challenge. In this study, using a rodent visceral pain assay that combines the colorectal distension (CRD)-induced visceromotor response (VMR) with the conditioning place avoidance (CPA), we measured a learned behavior that directly reflects the affective component of visceral pain. When CRD was paired with a distinct environment context, the rats spent significantly less time in this compartment on the post-conditioning test days as compared with the pre-conditioning day. Effects were lasted for 14 days. Bilateral pACC lesion significantly reduced CPA scores without reducing acute visceral pain behaviors (CRD-induced VMR). Bilateral administration of non-NMDA receptor antagonist CNQX or NMDA receptor antagonist AP5 into the pACC decreased the CPA scores. AP5 or CNQX at dose of 400 mM produced about 70% inhibition of CRD-CPA in the day 1, 4 and 7, and completely abolished the CPA in the day 14 after conditioning. We concluded that neurons in the pACC are necessary for the "aversiveness" of visceral nociceptor stimulation. pACC activation is critical for the memory processing involved in long-term negative affective state and prediction of aversive stimuli by contextual cue. Copyright © 2011 Elsevier Inc. All rights reserved.

Application of change-point analysis to determine winter sleep patterns of the raccoon dog (Nyctereutes procyonoides from body temperature recordings and a multi-faceted dietary and behavioral study of wintering

Directory of Open Access Journals (Sweden)

Mustonen Anne-Mari

2012-12-01

Full Text Available Abstract Background A multi-faceted approach was used to investigate the wintertime ecophysiology and behavioral patterns of the raccoon dog, Nyctereutes procyonoides, a suitable model for winter sleep studies. By utilizing GPS tracking, activity sensors, body temperature (Tb recordings, change-point analysis (CPA, home range, habitat and dietary analyses, as well as fatty acid signatures (FAS, the impact of the species on wintertime food webs was assessed. The timing of passive bouts was determined with multiple methods and compared to Tb data analyzed by CPA. Results Raccoon dogs displayed wintertime mobility, and the home range sizes determined by GPS were similar or larger than previous estimates by radio tracking. The preferred habitats were gardens, shores, deciduous forests, and sparsely forested areas. Fields had close to neutral preference; roads and railroads were utilized as travel routes. Raccoon dogs participated actively in the food web and gained benefit from human activity. Mammals, plants, birds, and discarded fish comprised the most important dietary classes, and the consumption of fish could be detected in FAS. Ambient temperature was an important external factor influencing Tb and activity. The timing of passive periods approximated by behavioral data and by CPA shared 91% similarity. Conclusions Passive periods can be determined with CPA from Tb recordings without the previously used time-consuming and expensive methods. It would be possible to recruit more animals by using the simple methods of data loggers and ear tags. Hunting could be used as a tool to return the ear-tagged individuals allowing the economical extension of follow-up studies. The Tb and CPA methods could be applied to other northern carnivores.

Application of change-point analysis to determine winter sleep patterns of the raccoon dog (Nyctereutes procyonoides) from body temperature recordings and a multi-faceted dietary and behavioral study of wintering.

Science.gov (United States)

Mustonen, Anne-Mari; Lempiäinen, Terttu; Aspelund, Mikko; Hellstedt, Paavo; Ikonen, Katri; Itämies, Juhani; Vähä, Ville; Erkinaro, Jaakko; Asikainen, Juha; Kunnasranta, Mervi; Niemelä, Pekka; Aho, Jari; Nieminen, Petteri

2012-12-13

A multi-faceted approach was used to investigate the wintertime ecophysiology and behavioral patterns of the raccoon dog, Nyctereutes procyonoides, a suitable model for winter sleep studies. By utilizing GPS tracking, activity sensors, body temperature (Tb) recordings, change-point analysis (CPA), home range, habitat and dietary analyses, as well as fatty acid signatures (FAS), the impact of the species on wintertime food webs was assessed. The timing of passive bouts was determined with multiple methods and compared to Tb data analyzed by CPA. Raccoon dogs displayed wintertime mobility, and the home range sizes determined by GPS were similar or larger than previous estimates by radio tracking. The preferred habitats were gardens, shores, deciduous forests, and sparsely forested areas. Fields had close to neutral preference; roads and railroads were utilized as travel routes. Raccoon dogs participated actively in the food web and gained benefit from human activity. Mammals, plants, birds, and discarded fish comprised the most important dietary classes, and the consumption of fish could be detected in FAS. Ambient temperature was an important external factor influencing Tb and activity. The timing of passive periods approximated by behavioral data and by CPA shared 91% similarity. Passive periods can be determined with CPA from Tb recordings without the previously used time-consuming and expensive methods. It would be possible to recruit more animals by using the simple methods of data loggers and ear tags. Hunting could be used as a tool to return the ear-tagged individuals allowing the economical extension of follow-up studies. The Tb and CPA methods could be applied to other northern carnivores.

A mixed methods evaluation of paediatric trainee preparedness to manage cardiopulmonary arrests.

Science.gov (United States)

Walsh, Órla; Lydon, Sinéad; O'Connor, Paul

2017-12-01

Paediatric cardiopulmonary arrest (CPA) survival rates are strongly linked to the training of the doctors responding to the event. This study sought to characterise the level of experience in managing CPAs among paediatric trainees and to investigate the nontechnical (NTS) required to effectively lead a paediatric CPA team. A mixed-methods research design was used. For the quantitative phase, a questionnaire was developed to assess training, confidence, and experiences related to CPA management. During the qualitative phase, 17 paediatric trainees participated in a series of critical incident technique (CIT) interviews to explore the NTS used during the management of paediatric CPAs. A total of 56 of 131 (37.1% response rate) trainees responded to the preparedness questionnaire. A total of 48.2% of respondents expressed low confidence in their skill as a team leader during the management of a CPA. The CIT interviews highlighted deficiencies in specific NTS (identifying options, prioritising, and identifying and utilising resources). Our results indicate that there is a desire for more training in CPA management among paediatric trainees, in particular as a team leader, which includes a focus on key NTS. What is Known • Levels of preparedness to be a paediatric cardiopulmonary arrests team member/leader are generally lower than desirable. • The importance of nontechnical skills to the effective performance of adult cardiopulmonary arrests teams has been identified. What is New • Levels of preparedness to be a cardiopulmonary arrests team member were higher than reported in US studies. • There is a need for greater training in cardiopulmonary arrest management which includes a focus on key nontechnical skills to include identifying options, prioritising, identifying and utilising resources.

POTENTIAL PRODUCTION OF CYCLOPIAZONIC ACID BY PENICILLIUM CAMEMBERTI STRAINS ISOLATED FROM CAMEMBERT TYPE CHEESE

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Miroslava Císarová

2012-10-01

Full Text Available The aim of this study was to isolate the strains of fungi from Camembert type cheese, identify them and to test isolated strains of Penicillium camemberti for their ability to produce cyclopiazonic acid. The description of micro- and macromorphological features was used for identification of Penicillium camemberti strains. Strains were subsequently in vitro tested on their potential ability to produce mycotoxin cyclopiazonic acid (CPA. All of the 14 strains of Penicillium camemberti, which were obtained from 20 samples of Camembert type cheese, were cultivated 7, 14, 21, 27 and 30 days on CYA medium at 10±1°C, 15±1°C and 25±1°C in the dark. For determination of CPA production ability by P. camemberti isolates in vitro was TLC used. After 7 days of cultivation cyclopiazonic acid was produced only by 5 from 14 strains cultivated at all cultivation temperatures. After 14 and 21 days of cultivation was CPA produced by 6 strains at all of cultivation temperatures. After 27 and 30 days of cultivation was CPA identified in 7 strains cultivated at all temperatures of cultivation. The other strains also produced mycotoxin, however, not at each temperature. The most productive at all temperatures and after all days were 5 out of 14 tested strains (S9, S10, S13, S18 and S19. Strains S6 and S16 did not produce CPA at any temperature. The lowest production after all days of cultivation was found at 10±1 °C (44% and the highest at 25±1 °C (85%.

The invisible addiction: Cell-phone activities and addiction among male and female college students

Science.gov (United States)

PETNJI YAYA, LUC HONORE; MANOLIS, CHRIS

2014-01-01

Background and aims: The primary objective of the present study was to investigate which cell-phone activities are associated with cell-phone addiction. No research to date has studied the full-range of cell-phone activities, and their relationship to cell-phone addiction, across male and female cell-phone users. Methods: College undergraduates (N = 164) participated in an online survey. Participants completed the questionnaire as part of their class requirements. The questionnaire took 10 and 15 minutes to complete and contained a measure of cell-phone addiction and questions that asked how much time participants spent daily on 24 cell-phone activities. Results: Findings revealed cell-phone activities that are associated significantly with cell-phone addiction (e.g., Instagram, Pinterest), as well as activities that one might logically assume would be associated with this form of addiction but are not (e.g., Internet use and Gaming). Cell-phone activities that drive cell-phone addiction (CPA) were found to vary considerably across male and female cell-phone users. Although a strong social component drove CPA for both males and females, the specific activities associated with CPA differed markedly. Conclusions: CPA amongst the total sample is largely driven by a desire to connect socially. The activities found to be associated with CPA, however, differed across the sexes. As the functionality of cell-phones continues to expand, addiction to this seemingly indispensable piece of technology becomes an increasingly realistic possibility. Future research must identify the activities that push cell-phone use beyond its “;tipping point” where it crosses the line from a helpful tool to one that undermines our personal well-being and that of others. PMID:25595966

The invisible addiction: cell-phone activities and addiction among male and female college students.

Science.gov (United States)

Roberts, James A; Yaya, Luc Honore Petnji; Manolis, Chris

2014-12-01

The primary objective of the present study was to investigate which cell-phone activities are associated with cell-phone addiction. No research to date has studied the full-range of cell-phone activities, and their relationship to cell-phone addiction, across male and female cell-phone users. College undergraduates (N = 164) participated in an online survey. Participants completed the questionnaire as part of their class requirements. The questionnaire took 10 and 15 minutes to complete and contained a measure of cell-phone addiction and questions that asked how much time participants spent daily on 24 cell-phone activities. Findings revealed cell-phone activities that are associated significantly with cell-phone addiction (e.g., Instagram, Pinterest), as well as activities that one might logically assume would be associated with this form of addiction but are not (e.g., Internet use and Gaming). Cell-phone activities that drive cell-phone addiction (CPA) were found to vary considerably across male and female cell-phone users. Although a strong social component drove CPA for both males and females, the specific activities associated with CPA differed markedly. CPA amongst the total sample is largely driven by a desire to connect socially. The activities found to be associated with CPA, however, differed across the sexes. As the functionality of cell-phones continues to expand, addiction to this seemingly indispensable piece of technology becomes an increasingly realistic possibility. Future research must identify the activities that push cell-phone use beyond its “tipping point” where it crosses the line from a helpful tool to one that undermines our personal well-being and that of others.

The 170ms Response to Faces as Measured by MEG (M170 Is Consistently Altered in Congenital Prosopagnosia.

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Andreas Lueschow

Full Text Available Modularity of face processing is still a controversial issue. Congenital prosopagnosia (cPA, a selective and lifelong impairment in familiar face recognition without evidence of an acquired cerebral lesion, offers a unique opportunity to support this fundamental hypothesis. However, in spite of the pronounced behavioural impairment, identification of a functionally relevant neural alteration in congenital prosopagnosia by electrophysiogical methods has not been achieved so far. Here we show that persons with congenital prosopagnosia can be distinguished as a group from unimpaired persons using magnetoencephalography. Early face-selective MEG-responses in the range of 140 to 200ms (the M170 showed prolonged latency and decreased amplitude whereas responses to another category (houses were indistinguishable between subjects with congenital prosopagnosia and unimpaired controls. Latency and amplitude of face-selective EEG responses (the N170 which were simultaneously recorded were statistically indistinguishable between subjects with cPA and healthy controls which resolves heterogeneous and partly conflicting results from existing studies. The complementary analysis of categorical differences (evoked activity to faces minus evoked activity to houses revealed that the early part of the 170ms response to faces is altered in subjects with cPA. This finding can be adequately explained in a common framework of holistic and part-based face processing. Whereas a significant brain-behaviour correlation of face recognition performance and the size of the M170 amplitude is found in controls a corresponding correlation is not seen in subjects with cPA. This indicates functional relevance of the alteration found for the 170ms response to faces in cPA and pinpoints the impairment of face processing to early perceptual stages.

Evaluation of clinical characteristics and prognosis of chronic pulmonary aspergillosis depending on the underlying lung diseases: Emphysema vs prior tuberculosis.

Science.gov (United States)

Koyama, Kazuya; Ohshima, Nobuharu; Suzuki, Junko; Kawashima, Masahiro; Okuda, Kenichi; Sato, Ryota; Suzukawa, Maho; Nagai, Hideaki; Matsui, Hirotoshi; Ohta, Ken

2015-11-01

There have been scarce data evaluating the differences of clinical characteristics and prognosis of chronic pulmonary aspergillosis (CPA) depending on underlying pulmonary diseases. We tried to clarify them in CPA patients who had pulmonary emphysema or previous pulmonary tuberculosis. We reviewed and evaluated CPA patients diagnosed between 2007 and 2013 with pulmonary emphysema (PE group; n = 29), with previous pulmonary tuberculosis (PT group; n = 47) and with combination of these 2 underlying conditions (CTE group; n = 24). In CT findings, fungus balls were rare in PE group (7% in PE group and 36% in PT group; p = 0.006). Compared with PT group, PE group patients exhibited more frequent preceding antibiotics administration (45% vs 11%; p = 0.002) and fever (52% vs 17%; p = 0.002), less frequent hemosputum (24% vs 57%; p = 0.008), and more frequent consolidations in imaging (79% vs 38%; p = 0.001) and respiratory failure (34% vs 13%; p = 0.020), possibly suggesting more acute clinical manifestations of CPA in emphysematous patients. Trend of the differences between PT and PE group was not changed when patients with fungal balls were excluded. Multivariate Cox regression analysis of risks for all-cause mortality revealed age (HR, 1.079; p = 0.002) and emphysema (HR, 2.45; p = 0.040) as risk factors. Assessment of underlying lung diseases is needed when we estimate prognosis and consider treatment of CPA patients. Particularly, emphysematous patients can be presented as refractory pneumonia and show poor prognosis. Copyright © 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Por que, Para que uma revista (tradução

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Doralicia Furtado da Rosa

2007-06-01

Full Text Available Tempo. Poder-se-ia vê-la assim: mais que um desafio ao tempo, a revista é um desafío no tempo. A literatura seria essa possibilidade de desafiar o tempo em um lapso maior que o da proximidade, que o do próximo do presente. A revista, pelo contrário, trabalha para o presente, para a difusão do conto ou do poema ou do artigo ou do capítulo de romance. Logo, com sorte, esses textos estarão destinados a circular em livro ou então a ficarem pendentes no espaço cibernético até que alguém os recolha, até que alguém os “baixe” da internet. Ou se perderão para sempre ou se transformarão em referência de nota de rodapé em alguma tese de doutorado, para regozijo de eruditos ou como monótono insumo para a obtenção de um grau ou de um cargo universitário. Isso significa, como cria Borges, que “um periódico se lê para o olvido”, ao passo que “um livro se lê para a memória”? (BORGES, 1979, p.25.

UMA PROSPOSTA DEDUTIVISTA PARA PRINCÍPIOS CONTÁBEIS

OpenAIRE

Paulo Schmidt

2009-01-01

A proposta deste estudo a apresentar um breve relato sobre a evolução do pensamento cientifico ocorrida na física com a substituição dos princípios contábeis e filosófico, desde a Antiguidade grega ate os dias de hoje, como forma de fundamentar o posicionamento contrario ao raciocínio indutivo para o estabelecimento de uma estrutura conceitual para a contabilidade e para o desenvolvimento dos princípios contábeis. Apos essa incursão pelo campo filosófico, será aduzido um dos trabalhos d...

Un nuevo contexto para la experiencia de usuario

OpenAIRE

Capossio, Ana Paula

2014-01-01

¿Cómo afecta la incorporación de metodologías de diseño centrado en el usuario (DCU) al momento de diseñar una experiencia para una instalación interactiva? Uno de los factores más importantes para una obra de arte interactivo es el usuario, ya que es el que interactúa directamente con la interfaz de la obra. El desafío del artista es conseguir diseñar una interfaz que los usuarios comprendan y entiendan el significado de la obra. Para poder lograr una mejor experiencia de usuario, el arti...

Plan integral de negocios para la Empresa Rodeport

OpenAIRE

Banegas Lucero, Tania Maribel; Tacuri Flores, Diana Patricia

2007-01-01

El siguiente trabajo de investigación está dividido en 5 capítulos los cuales son de suma importancia para el desarrollo y aplicación de las estrategias para la empresa Rodeport. En el primer capítulo se habla sobre los conceptos principales de un área funcional muy importante en cualquier organización y esta es FINANZAS. La cual habla la manera en que la gente asigna recursos y divide el dinero, los costos que intervienen en esta área para el cálculo pero sobre todo, los principales estad...

Toxin genotyping of Clostridium perfringens strains using a polymerase chain reaction protocol

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Elisabetta Di Giannatale

2010-03-01

Full Text Available A polymerase chain reaction protocol consisting of a multiplex to identify the cpa, cpb1, cpetx, cpi genes and a duplex to identify the cpe and cpb2 genes encoding for a, b1, e, i, enterotoxin and b2 toxins, respectively, was applied to DNA extracted from two collections of Clostridium perfringens strains. The first collection involved 19 isolates from rabbits. The second collection of 41 isolates came from routine necropsies. The cpa gene alone, or in association with the cpb2 gene, was detected in all DNA samples examined. The cpa gene, together with cpb2 gene, were detected in seven of the rabbit C. perfringens strains (36.8% and in nine isolates from necropsies (21.9%. The cpa gene was found in 63.2% of rabbit strains and 76.9% of strains from other animal species. In rabbits, the pathological lesions associated with C. perfringens detection were predominantly forms of non-inflammatory enteropathies. In other species, C. perfringens was mainly associated with congestive-haemorrhagic enteropathy, but also with fatal traumatic lesions, degenerative diseases and organs with post-mortem autolysis. No clear correlation was observed between detection of b2 toxin gene and species-specific pathological features.

Anticipatory and Compensatory Postural Adjustments in Response to External Lateral Shoulder Perturbations in Subjects with Parkinson's Disease.

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Alexandre Kretzer E Castro de Azevedo

Full Text Available The purpose of this study was to investigate the anticipatory (APA and compensatory (CPA postural adjustments in individuals with Parkinson's disease (PD during lateral instability of posture. Twenty-six subjects (13 individuals with PD and 13 healthy matched controls were exposed to predictable lateral postural perturbations. The electromyographic (EMG activity of the lateral muscles and the displacement of the center of pressure (COP were recorded during four time intervals that are typical for postural adjustments, i.e., immediately before (APA1, APA2 and after (CPA1 and CPA2 the postural disturbances. The magnitude of the activity of the lateral muscles in the group with PD was lower only during the CPA time intervals and not during the anticipatory adjustments (APAs. Despite this finding, subjects with PD exhibit smaller COP excursions before and after the disturbance, probably due to lack of flexibility and proprioceptive impairments. The results of this study suggest that postural instability in subjects with PD can be partially explained by decreased postural sway, before and after perturbations, and reduced muscular activity after body disturbances. Our findings can motivate new studies to investigate therapeutic interventions that optimize the use of postural adjustment strategies in subjects with PD.

Solid phase excitation-emission fluorescence method for the classification of complex substances: Cortex Phellodendri and other traditional Chinese medicines as examples.

Science.gov (United States)

Gu, Yao; Ni, Yongnian; Kokot, Serge

2012-09-13

A novel, simple and direct fluorescence method for analysis of complex substances and their potential substitutes has been researched and developed. Measurements involved excitation and emission (EEM) fluorescence spectra of powdered, complex, medicinal herbs, Cortex Phellodendri Chinensis (CPC) and the similar Cortex Phellodendri Amurensis (CPA); these substances were compared and discriminated from each other and the potentially adulterated samples (Caulis mahoniae (CM) and David poplar bark (DPB)). Different chemometrics methods were applied for resolution of the complex spectra, and the excitation spectra were found to be the most informative; only the rank-ordering PROMETHEE method was able to classify the samples with single ingredients (CPA, CPC, CM) or those with binary mixtures (CPA/CPC, CPA/CM, CPC/CM). Interestingly, it was essential to use the geometrical analysis for interactive aid (GAIA) display for a full understanding of the classification results. However, these two methods, like the other chemometrics models, were unable to classify composite spectral matrices consisting of data from samples of single ingredients and binary mixtures; this suggested that the excitation spectra of the different samples were very similar. However, the method is useful for classification of single-ingredient samples and, separately, their binary mixtures; it may also be applied for similar classification work with other complex substances.

Exploring the Impact of Childhood Abuse on HIV Social and Attitudinal Factors Among Adults With and Without this History in Sub-Saharan Africa: Findings from NIMH Project Accept (HPTN 043).

Science.gov (United States)

Richter, Linda; Makusha, Tawanda; Komárek, Arnošt; Daniels, Joseph; Coates, Tom

2016-04-01

Using data from four sites in three African countries, this community randomized study examined the association between childhood sexual and/or physical abuse (CSA and/or CPA) and HIV disclosure, HIV-related stigma, stress, and social support among adults with and without a history of abuse. A history of abuse among men was associated with higher levels of adult-reported stress and HIV-related stigma, and with significantly lower rates of HIV test result disclosure to current partners. Women with a history of CSA and/or CPA had significantly higher perceived stigma, discrimination and stress. Although childhood abuse was significantly associated with adult stress and stigmatization, participants with histories of CSA and/or CPA also reported significantly higher perceived social support compared to people without such experiences. These findings may reflect support received in response to disclosure of CSA or CPA or emotional ambivalence in relationships that have been found to be associated with child abuse. We conclude that it is critical for HIV prevention interventions to advocate for the primary prevention of child abuse, for early identification of adolescents and adults who report experiencing childhood abuse, and to address stigma and stress-related attitudinal, behavioral and relationship difficulties experiences as an aftermath of early abuse that increase their risk of HIV.

Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency

Science.gov (United States)

Weng, Rui; Shen, Sensen; Tian, Yonglu; Burton, Casey; Xu, Xinyuan; Liu, Yi; Chang, Cuilan; Bai, Yu; Liu, Huwei

2015-07-01

Serotonin is an important neurotransmitter that broadly participates in various biological processes. While serotonin deficiency has been associated with multiple pathological conditions such as depression, schizophrenia, Alzheimer’s disease and Parkinson’s disease, the serotonin-dependent mechanisms remain poorly understood. This study therefore aimed to identify novel biomarkers and metabolic pathways perturbed by serotonin deficiency using metabolomics approach in order to gain new metabolic insights into the serotonin deficiency-related molecular mechanisms. Serotonin deficiency was achieved through pharmacological inhibition of tryptophan hydroxylase (Tph) using p-chlorophenylalanine (pCPA) or genetic knockout of the neuronal specific Tph2 isoform. This dual approach improved specificity for the serotonin deficiency-associated biomarkers while minimizing nonspecific effects of pCPA treatment or Tph2 knockout (Tph2-/-). Non-targeted metabolic profiling and a targeted pCPA dose-response study identified 21 biomarkers in the pCPA-treated mice while 17 metabolites in the Tph2-/- mice were found to be significantly altered compared with the control mice. These newly identified biomarkers were associated with amino acid, energy, purine, lipid and gut microflora metabolisms. Oxidative stress was also found to be significantly increased in the serotonin deficient mice. These new biomarkers and the overall metabolic pathways may provide new understanding for the serotonin deficiency-associated mechanisms under multiple pathological states.

An evaluation of aflatoxin and cyclopiazonic acid production in Aspergillus oryzae.

Science.gov (United States)

Kim, Nam Yeun; Lee, Jin Hee; Lee, Inhyung; Ji, Geun Eog

2014-06-01

To date, edible fungi such as Aspergillus flavus var. oryzae (A. oryzae) has been considered as safe. However, some strains can produce mycotoxins. Thus, the biosynthetic ability to produce mycotoxins should be reevaluated to determine the safety of edible fungi. We analyzed the production of aflatoxins and cyclopiazonic acid (CPA) from edible fungi such as A. oryzae isolated from various Korean foods using multiplex PCR, enzyme-linked immunosorbent assay, and high-performance liquid chromatography (HPLC). In the multiplex PCR analysis of aflatoxin biosynthetic genes omtB, aflR, ver-1, and omtA, 5 of 19 Aspergillus strains produced all PCR products. Among them, aflatoxin B1 and aflatoxin B2 were detected from only A. flavus KACC 41403 by HPLC. Aflatoxins were not detected from the other four strains that produced all positive PCR bands. Aflatoxin also was not detected from 12 strains that had PCR patterns without aflR or ver-1 and from 2 strains that did not produce any of the expected PCR products. Only the seven A. oryzae strains that produced all of the positive PCR bands including the CPA biosynthetic genes maoA, dmaT, and pks-nrps produced CPA. CPA and aflatoxin production must be evaluated before A. oryzae strains are used for the development of fermented foods.

Analizador de Frecuencia: una nueva aplicación docente para Android

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José A. Gómez-Tejedor

2014-03-01

Full Text Available En este trabajo se presenta una aplicación para dispositivo móvil Android capaz de medir la frecuencia fundamental de un sonido de forma muy precisa. Esta aplicación puede ser utilizada en campos tan diversos como la música para afinar instrumentos musicales, en física para la medida del efecto Doppler o en sistemas de reconocimiento del habla para determinar la frecuencia fundamental de la voz. En concreto, en este trabajo presentamos algunos ejemplos en el campo de la física relacionados con el efecto Doppler para ondas acústicas.

El Derecho Agrario como derecho para la paz

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Ricardo Zeledón Zeledón

2015-01-01

Full Text Available Contenido: El Derecho agrario surgido de la paz y para la consolidación de la paz, como fuente e instrumento para su cumplimiento. La visión de Carrozza como conjunto de reglas destinadas al fin de la paz, y la equidad. Explicación de un Derecho agrario vinculado a la paz por su origen en los Derechos Humanos Económicos y Sociales. Evolución del Derecho Agrario en los Derechos Humanos de la tercera generación (principalmente ambiente, desarrollo y paz, en las nuevas dimensiones del Derecho agrario del futuro. Derecho agrario como derecho para la paz y el respeto de los derechos humanos. Desarrollo sostenible y agricultura del futuro. La nueva orientación de los institutos del derecho agrario como instrumentos de paz, dirigidos a cumplir los fines de la justicia social, el desarrollo económico y el equilibrio ambiental. Desarrollo como respuesta a los problemas del ambiente, alimentario, de la pobreza, indígena y de la mujer rural. El rol de la justicia agraria y ambiental como derecho para la paz. El derecho agrario, disciplina forjada en una concepción iushumanista, acorde con los derechos humanos y la paz. El derecho agrario como derecho para la paz.

Proyecto curricular institucional: Una alternativa para el cambio

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Ruth Vallejo

2002-01-01

Full Text Available Enfrentar el desafío de la construcción del proyecto curricular institucional representa para la educación de este milenio una prioridad, esto sin lugar a dudas, requiere de un cambio en la estructura organizativa y de gestión en cada plantel; el Currículo Básico Nacional, en marcha, representa un avance significativo, para superar esta situación. Para que esta reforma constituya una alternativa válida, es necesario abordar la formación del docente de forma sistemática, continúa desde su praxis por medio de la investigación-acción, utilizando herramientas metodológicas para el diagnóstico y acompañando todo el proceso con una evaluación institucional que al mismo tiempo que se analiza e implementa permita la formación de los actores involucrados; la revisión y los ajustes permanentes conducen a la construcción de aproximaciones sucesivas que con el trabajo concertado garantizan la viabilidad del proyecto. Se recomienda asumirlo con un carácter cíclico y dinámico para decidir si se puede o no mantener a la luz de los cambios que ocurran dentro y fuera del proceso.

Imaging of limbic para-neoplastic encephalitis

International Nuclear Information System (INIS)

Rimmelin, A.; Sellat, F.; Morand, G.; Quoix, E.; Clouet, P.L.; Dietemann, J.L.

1997-01-01

Para-neoplastic limbic encephalitis is a rare syndrome mostly associated with small cell lung cancer. We present the case of a 69-year-old man with selective amnesia suggesting limbic encephalitis. A neuroendocrine cell lung cancer was found, confirming the diagnostics of para-neoplastic limbic encephalitis. Contrast-enhanced cerebral CT was normal whether magnetic resonance imaging showed signal abnormalities of the medial part of temporal lobes and hippocampal regions. Because neurologic improvement may follow treatment of the primary tumor, early diagnosis is important. (authors)

Coherent-potential approximation for vibrations in Ga/sub 1-x/In/sub x/Sb and Ga/sub 1-x/In/sub x/As mixed crystals

International Nuclear Information System (INIS)

Kleinert, P.

1982-01-01

The vibrational properties of the mixed crystals Ga/sub 1-x/In/sub x/As and Ga/sub 1-x/In/sub x/Sb are investigated using the coherent-potential approximation (CPA). These III-V systems switch from one-mode to two-mode behaviour as the composition is changed. Results are obtained for a one-dimensional model including self-consistently mass defects and force constant changes. The calculated density of states and the dielectric susceptibility are compared with results of the mass CPA. In addition, a three-dimensional CPA Bethe lattice treatment is carried out to calculate the optical properties of these disordered systems showing mixed-mode behaviour. The force-constant change is included by a virtual-crystal interpolation. The theory explains the mode switching behaviour and agrees fairly well with experimental peak positions and line shapes of the response function. (author)

Performance assessment of static lead-lag feedforward controllers for disturbance rejection in PID control loops.

Science.gov (United States)

Yu, Zhenpeng; Wang, Jiandong

2016-09-01

This paper assesses the performance of feedforward controllers for disturbance rejection in univariate feedback plus feedforward control loops. The structures of feedback and feedforward controllers are confined to proportional-integral-derivative and static-lead-lag forms, respectively, and the effects of feedback controllers are not considered. The integral squared error (ISE) and total squared variation (TSV) are used as performance metrics. A performance index is formulated by comparing the current ISE and TSV metrics to their own lower bounds as performance benchmarks. A controller performance assessment (CPA) method is proposed to calculate the performance index from measurements. The proposed CPA method resolves two critical limitations in the existing CPA methods, in order to be consistent with industrial scenarios. Numerical and experimental examples illustrate the effectiveness of the obtained results. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

Electron beam production by a plasma focus

International Nuclear Information System (INIS)

Smith, J.R.; Luo, C.M.; Schneider, R.F.; Rhee, M.J.

1984-01-01

Operation of a plasma focus as a Compact Pulsed Accelerator (CPA) for ions has been previously reported. The CPA consists of: (1) a 15 μF, 3 kJ capacitor, (2) a triggered spark gap, (3) a coaxial transmission line, and (4) a Mather geometry plasma gun. Recently the authors have investigated application of the CPA as an accelerator for electrons. In the previously reported work using the standard Mather plasma gun geometry, ions were accelerated away from the plasma gun and were therefore conveniently extracted for analysis, but electrons were directed into the hollow anode where extraction is blocked by the coaxial transmission line. For investigation of accelerated electrons a new plasma gun design which allows extraction of electrons has been developed. Details of the new plasma gun design and further results of beam diagnostics are discussed

CT and MR Imaging Characteristics of Intravestibular and Cerebellopontine Angle Lipoma

International Nuclear Information System (INIS)

Buyukkaya, Ramazan; Buyukkaya, Ayla; Ozturk, Beyhan; Yaman, Huseyin; Belada, Abdullah

2014-01-01

Intracranial lipoma is an uncommon entity. A rare type of tumor in the internal auditory canal (IAC) and the cerebellopontine angle (CPA) is lipoma. There are a few case reports in the literature related to intravestibular lipoma. Herein, we report a case of lipomas within the cerebellopontine angle and vestibule of the inner ear in a patient with tinnitus and dizziness. The patient was evaluated with a 1.5 T magnetic resonance imaging (MRI) system. MRI and CT showed the masses in the left CPA and the left IAC. These lesions were hyperintense on both T1- and T2 weighted images and showed no enhancement after gadolinium administration. Conservative management was suggested. Histopathological diagnosis is rarely necessary with the widespread use of magnetic resonance imaging. Considering significant morbidity during resection, conservative follow-up is the best approach for CPA and IAC lipoma

CT and MR Imaging Characteristics of Intravestibular and Cerebellopontine Angle Lipoma

Energy Technology Data Exchange (ETDEWEB)

Buyukkaya, Ramazan [Department of Radiology, School of Medicine, Duzce University, Duzce (Turkey); Buyukkaya, Ayla [Department of Radiology, Duzce Ataturk Government Hospital, Duzce (Turkey); Ozturk, Beyhan [Department of Radiology, School of Medicine, Duzce University, Duzce (Turkey); Yaman, Huseyin; Belada, Abdullah [Department of Ear Nose and Throat, School of Medicine, Duzce University, Duzce (Turkey)

2014-06-15

Intracranial lipoma is an uncommon entity. A rare type of tumor in the internal auditory canal (IAC) and the cerebellopontine angle (CPA) is lipoma. There are a few case reports in the literature related to intravestibular lipoma. Herein, we report a case of lipomas within the cerebellopontine angle and vestibule of the inner ear in a patient with tinnitus and dizziness. The patient was evaluated with a 1.5 T magnetic resonance imaging (MRI) system. MRI and CT showed the masses in the left CPA and the left IAC. These lesions were hyperintense on both T1- and T2 weighted images and showed no enhancement after gadolinium administration. Conservative management was suggested. Histopathological diagnosis is rarely necessary with the widespread use of magnetic resonance imaging. Considering significant morbidity during resection, conservative follow-up is the best approach for CPA and IAC lipoma.

Fluid phase equilibria of the reaction mixture during the selective hydrogenation of 2-butenal in dense carbon dioxide

DEFF Research Database (Denmark)

Musko, Nikolai; Jensen, Anker Degn; Baiker, Alfons

2012-01-01

Knowledge of the phase behaviour and composition is of paramount importance for understanding multiphase reactions. We have investigated the effect of the phase behaviour in the palladium-catalysed selective hydrogenation of 2-butenal to saturated butanal in dense carbon dioxide. The reactions were...... cell. The results of the catalytic experiments showed that small amounts of carbon dioxide added to the system significantly decrease the conversion, whereas at higher loadings of CO2 the reaction rate gradually increases reaching a maximum. The CPA calculations revealed that this maximum is achieved...... performed using a 5wt% Pd on activated carbon in custom-designed high pressure autoclaves at 323K. The Cubic-Plus-Association (CPA) equation of state was employed to model the phase behaviour of the experimentally studied systems. CPA binary interaction parameters were estimated based on the experimental...

LOS BUENOS HÁBITOS DE ESCRITURA, EMPIEZAN EN LA ESCUELA, LO MISMO PARA DIESTROS QUE PARA ZURDOS

Directory of Open Access Journals (Sweden)

José Quintanal Díaz

2011-01-01

Full Text Available Los buenos hábitos de escritura, empiezan en la escuela, lo mismo para diestros que zurdos. La escritura es uno de los aprendizajes que se automatizan con mayor rapidez en los primeros estadios del desarrollo infantil. Esto supone que la escuela deba estar atenta para conseguir su correcta aplicación, de modo que los pequeños integren este hábito con corrección. Lo mismo diestros que zurdos; para todos, un buen aprendizaje de esta destreza les va a suponer no sólo contar con una mejora en su comunicación, pues su escrito resultará más legible y presentará una mayor calidad técnica, sino que se prevendrán las secuelas propias de su posterior ejecución. El presente estudio analiza cómo adecuar el proceso de enseñanza de la escritura desde la escuela infantil.

Rituximab para la oftalmopatía asociada a la tiroides

Directory of Open Access Journals (Sweden)

Neda Minakaran

2013-09-01

Conclusiones de los autores: Actualmente no hay pruebas suficientes para apoyar la administración de rituximab en los pacientes con OAT. Se necesitan ECA grandes que investiguen rituximab versus placebo o corticosteroides en pacientes con OAT activo para hacer valoraciones adecuadas sobre la eficacia y la seguridad de este tratamiento nuevo para esta enfermedad.

Jõhvis tuleb parasürrealistide näitus

Index Scriptorium Estoniae

2008-01-01

Jõhvi kontserdimajas avatakse parasürrealistide rühmituse PARA näitus "Panoraam". Osalevad Ilmar Malin (maalid), Jüri Palm (maalid), Elo Järv (nahkskulptuurid), Vello Vinn (graafika), Leonhard Lapin (akvarellid), Enn Tegova (maalid), Ahti Seppet (puuskulptuurid), Raivo Kelomees (maalid), Kristiina Viin (joonistused ja maalid)

para mejorar el %R

Directory of Open Access Journals (Sweden)

Alfredo Díaz Mata

2001-01-01

Full Text Available En este trabajo se revisan dos indicadores técnicos bursátiles que están estrechamente relacionados, el oscilador estocástico %K de Lane y el oscilador %R de Williams; asimismo, se evalúa el uso de dos mecanismos asociados con el primero y que no suelen utilizarse con el %R: el proceso de frenado (slowing y el uso de un promedio móvil del propio oscilador estocástico como disparadores de señales de compra y de venta. Realizando simulaciones con 27 acciones y el Índice de Precios y Cotizaciones de la Bolsa Mexicana de Valores se verifica la hipótesis principal y se comprueba que, efectivamente, en muchos casos, el uso del proceso de frenado con el oscilador %R de Williams permite tomar mejores decisiones. Por otro lado, se concluye que de los dos disparadores de señales el que mejor funciona, tanto para %K como para %R es el uso de cotas inferior y superior. Este artículo surgió en el curso de una investigación sobre el análisis técnico bursátil de acciones que se puede realizar en su totalidad por computadora y que, esencialmente, excluye el análisis gráfico. Uno de los propósitos del estudio es determinar si es posible, y bajo qué mecanismos, establecer un sistema de análisis bursátil que le permita al inversionista tomar decisiones de inversión en acciones en la Bolsa Mexicana de Valores sin tener que emplear la considerable cantidad de tiempo que es necesario para el análisis gráfico tradicional. Durante este estudio se realizó un análisis preliminar de unos 120 indicadores técnicos para, por un lado, conocerlos con cierto detalle y, por otra parte, aislar aquellos que prometían ser de utilidad para el objetivo de la investigación. Fue en este proceso cuando se detectó que existen dos indicadores que están relacionados y que permiten un análisis por separado que tiene, cuando menos, dos ventajas. En primer lugar está el placer que da a quien gusta de estos temas encontrarse con indicadores que, de acuerdo

para la Depresión en Adolescentes (EADA

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Mirella Díaz-Santos

2008-01-01

Full Text Available Los instrumentos que miden autoeficacia en jóvenes son mayormente escalas para adultos adaptadas para evaluar adolescentes o escalas de autoeficacia general. El propósito de este estudio fue desarrollar y evaluar las propiedades psicométricas de la Escala de Autoeficacia para la Depresión en Adolescentes (EADA. Además, administramos la versión en español de la subescala de Autoeficacia Emocional del Self-Efficacy Questionnaire for Children, así como el Inventario de Depresión en Niños/as-Versión Corta, para evaluar la validez concurrente entre estas medidas. Participaron 116 adolescentes entre 13 a 17 años. Los resultados indican que la EADA posee una consistencia interna y una validez concurrente excelente. Los mismos apoyan su adecuación como instrumento que evalúa la auto-percepción de confianza del/de la adolescente al enfrentar situaciones típicas del Trastorno Depresivo Mayor.

PERFIL PARA REPRESENTAR UNA ARQUITECTURA DE COMPONENTES EN UML

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Fernando Orejas Valdés

2006-04-01

Full Text Available

El lenguaje unificado de modelado (Unified Modeling Language, UML es un lenguaje de modelado estándar para problemas generales, sin embargo, es necesario extenderlo para dominios específicos como puede ser el caso de determinadas arquitecturas. Aquí se presenta una extensión mediante un perfil para una arquitectura de componentes y conectores genéricos.

Educación para la paz

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Federico Mayor Zaragoza

2003-01-01

Full Text Available La educación para la paz ha experimentado un desarrollo importante en los últimos 20 años, y el 2000 ha sido declarado Año Internacional para la Cultura de Paz. Exige un esfuerzo de pariicipación y una capacidad crítica para facilitar el paso de una cultura de guerra a un cultura de paz. Se trata de ayudar a todos los ciudadanos a observar y reflexionar sobre el conjunto de la tierra y de quienes la habitan. De escuchar a los jóvenes y ser escuchado. La educación para la paz ha de ser considerada como contenido transversal de la educación. La situación actual, los conflictos interétnicos e interculturales , la exclusión y la marginalidad, las sociedades pobres y las ricas son cuestiones que reclaman una educación par la paz. De la cultura de imposición hemos de pasar a la cultura del diálogo y parti-cipación, solidaridad, compromiso, tolerancia y respeto. Es necesario construir otro mundo en el que podamos asegurar a nuestros descendientes el futuro. La paz es un comportamiento, es traducir a la práctica los principios de con-vivencia, de solidaridad, de fraternidad. Sólo así «vendrá el amanecer (y brilla-rá mucha luz en nuestro camino»

High-performance mirror for space applications using anodic bonding technology

Science.gov (United States)

Otto, W.; Fischer, E.; Kemper, J.; Koch, S.; Kolberg, J.; Kramer, C.; Kunde, J.; Läger, M.

2017-11-01

Berliner Glas developed and manufactured the plane elliptical shaped mirrors for the Synopta Coarse Pointing Assembly (CPA) being one of the key elements of the TESAT Spacecom Laser Communication Terminals (LCT's). The first TESAT LCT containing a Synopta CPA was embarked on Sentinel 1A and is in orbit since April 2014. TESAT Spacecom LCT's have been successfully tested in space since 2007 and are now operationally used in commercial satellite communication systems.

A review of the nonmarket strategy literature: toward a multi-theoretical integration

OpenAIRE

Mellahi, Kamel; Frynas, Jedrzej George; Sun, Pei; Siegel, Donald

2016-01-01

Two parallel strands of nonmarket strategy research have emerged that are largely in isolation. One strand examines strategic corporate social responsibility (CSR) and the other examines corporate political activity (CPA), even though there is an overlap between the social and political aspects of corporate strategies. In this paper, we review and synthesize strategic CSR and CPA research published in top-tier and specialized academic journals between 2000 and 2014. Specifically, we (a) revie...

Facial Nerve Schwannoma of the Cerebellopontine Angle: A Diagnostic Challenge

OpenAIRE

Lassaletta, Luis; Roda, José María; Frutos, Remedios; Patrón, Mercedes; Gavilán, Javier

2002-01-01

Facial nerve schwannomas are rare lesions that may involve any segment of the facial nerve. Because of their rarity and the lack of a consistent clinical and radiological pattern, facial nerve schwannomas located at the cerebellopontine angle (CPA) and internal auditory canal (IAC) represent a diagnostic and therapeutic challenge for clinicians. In this report, a case of a CPA/IAC facial nerve schwannoma is presented. Contemporary diagnosis and management of this rare lesion are analyzed.

Processo de ensino e aprendizagem de Língua Portuguesa como L2 para surdos: elementos para o ensino de leitura

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Eliamar Godoi

2014-12-01

Full Text Available Esse estudo tem por finalidade compartilhar com o professor de salade aula de ensino regular que recebem surdos alfabetizados algunselementos para o ensino de leitura. Justifica-se pela escassez de pesquisassobre a prática pedagógica, recursos didáticos e tecnológicos para oensino de leitura para surdos. A partir de levantamento das principaisdificuldades relatadas por professores em relação ao ensino de leiturapara surdo, foi feita uma discussão que atualiza o docente em relaçãoàs frequentes dificuldades descritas nesse processo. Apresentamossugestões sobre como trabalhar e receber um aluno surdo na salaregular de ensino e ainda alguns aspectos linguísticos do ensino deLeitura para alunos surdos. A concepção desse trabalho permite váriosdesdobramentos, tanto na sua formulação teórica e prática quantona sua realização, uma vez que leva em consideração a formação deprofessores interessados em atuar na perspectiva inclusiva da Educação.O procedimento metodológico escolhido foi o debate mediado por umapesquisa bibliográfica pautada em abordagens de autores da LinguísticaTextual complementada pelos da Educação Especial e, ainda, por autoresdo ensino de Língua Portuguesa como L2 para Surdos. Dessa forma, estareflexão, busca apresentar a análise de algumas práticas de ensino de Leitura e de Língua Portuguesa para surdos e sugerir algumas ações. Apartir desse estudo, concluímos que, na sala regular de ensino, existemfatores que podem levar o surdo à produção de sentido e à constituiçãode um sujeito leitor que também escreve, nas aulas, sobretudo, deLíngua Portuguesa.

Polymorphism and modulation of para-substituted L-Phenylalanine

NARCIS (Netherlands)

Sögütoglu, Leyla-cann; Lutz, Martin; Meekes, Hugo; De Gelder, Rene; Vlieg, Elias

2017-01-01

The crystal structure of para-methyl-L-phenylalanine at 230 K resembles that of the para-fluorinated analogue from the literaturebut is commensurately modulated with seven molecules in the asymmetric unit (Z′ = 7). At 100 K, the superstructure loses its modulation, leading to a unit cell with Z′ =

Relojes de agua, una oportunidad para calcular integrales

OpenAIRE

Thiabut, Elena

2007-01-01

Este artículo propone una investigación sobre clepsidras (relojes de agua) para alumnos de 2º de bachillerato. El cálculo integral será la clave para descubrir cómo la geometría de los recipientes condiciona el funcionamiento de estos mecanismos milenarios.