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Sample records for fronto-orbital sphenoethmoidal fibrous

  1. Frontal mucocele with an accompanying orbital abscess mimicking a fronto-orbital mucocele: case report

    OpenAIRE

    Akkuzu Guzin; Aydin Erdinc; Akkuzu Babur; Bilezikci Banu

    2006-01-01

    Abstract Background Mucoceles are slowly expanding cystic lesions with respiratory epithelium containing mucus most commonly affecting the frontal and ethmoidal sinuses. They are caused by obstruction of sinus ostium. Mucoceles exert pressure on the bony boundaries and due to the proximity to the brain and orbit extension to these areas are common. Case presentation A case of a frontal mucocele with an accompanying orbital abscess mimicking a fronto-orbital mucocele is reported. A 77 year old...

  2. Frontal mucocele with an accompanying orbital abscess mimicking a fronto-orbital mucocele: case report

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    Akkuzu Guzin

    2006-04-01

    Full Text Available Abstract Background Mucoceles are slowly expanding cystic lesions with respiratory epithelium containing mucus most commonly affecting the frontal and ethmoidal sinuses. They are caused by obstruction of sinus ostium. Mucoceles exert pressure on the bony boundaries and due to the proximity to the brain and orbit extension to these areas are common. Case presentation A case of a frontal mucocele with an accompanying orbital abscess mimicking a fronto-orbital mucocele is reported. A 77 year old female patient suffering from left sided proptosis and pain around the left eye was admitted to our department. She had a history of left frontal sinus mucocele one year ago that was offered an osteoplastic frontal sinus surgery that the patient refused. Patient had limitation of eye movements. Fundoscopic examination revealed a minimal papilledema. Coronal computerized tomography and orbital magnetic resonance imaging showed a frontal mucocele with suspicious erosion of the orbital roof and a superiorly localized extraconal mass displacing the orbit lateroinferiorly. Frontal and orbital masses had similar intensities. Thus surgery was planned for a fronto-orbital mucocele. During surgery no defect was found on the orbital roof. Frontal mucocele and orbital cystic mass was removed separately. Pathological examination showed a frontal mucocele and an orbital abscess wall. Postoperatively eye movements returned to normal and papilledema resolved. Conclusion Fronto-orbital mucoceles are commonly encountered pathologies, but frontal mucocele with an orbital abscess is a rarely seen and should be kept in mind because their treatments differ.

  3. Magnetic resonance findings of spheno-ethmoidal mucocele

    Energy Technology Data Exchange (ETDEWEB)

    Balm, A.J.M. (Free University Hospital, Amsterdam (Netherlands). Department of Otolaryngology); Kole, F.D. (Free University Hospital, Amsterdam (Netherlands). Department of Ophthalmology); Slegte, R.G.M. de; Kaiser, M.C. (Free University Hospital, Amsterdam (Netherlands). Department of Neuroradiology)

    A mucocele of the spheno-ethmoidal sinus is described with symtoms of diplopia gradually leading to seriously impaired vision. This lesion was seen as a high signal intensity structure with all MRI pulse sequences due to deposits of methaemoglobulin consecutive to spontaneous bleedings inside the mucocele. These MRI findings have not been reported previously in the literature. (Author). 10 refs.; 1 fig.

  4. The Christmas tree foreheadplasty: a novel technique used in combination with a bandeau for fronto-orbital remodelling in craniosynostosis.

    Science.gov (United States)

    Britto, Jonathan A; Gwanmesia, Ivo; Leshem, David

    2012-09-01

    Craniosynostosis of the coronal, metopic and frontosphenoidal sutures results in deformity of the forehead. This may cause both functional and psychological difficulties for patient and parent. We describe a novel surgical technique, the 'Christmas tree foreheadplasty', used in combination with a supraorbital bandeau to achieve fronto-orbital remodelling. Between November 2008 and September 2011, 32 patients with craniosynostosis underwent fronto-orbital remodelling with a supraorbital bandeau in combination with Christmas tree foreheadplasty. Indications for surgery, age at surgery, blood transfusion requirements, length of hospital stay and perioperative complications were assessed. A 'blinded', independent reviewer, age-matched controlled, panel photograph study was also undertaken to review results of the surgery. A parental satisfaction survey by telephone questionnaire was undertaken. Mean age at surgery was 16 months. Average hospital stay was 3 days. Mean follow up time to this report was 19.5 months. Indications for the procedure included unicoronal, frontosphenoidal, metopic and bicoronal synostosis. Thirty of the 32 patients required a blood transfusion. One patient has required revision surgery following extrusion of prosthetic fixation plate. Surgical outcome measured by 'blinded' independent reviewers indicated that a significantly different preoperative score from normal was rendered to no significant difference from age-matched normal controls postoperatively. Parental satisfaction score of forehead appearance was significantly improved by the technique. The Christmas tree foreheadplasty is a commendable and reproducible technique for forehead remodelling in combination with supraorbital bandeau and is now used more widely for forehead reconstruction for congenital cases.

  5. Basal sphenoethmoidal encephalocele in association with midline cleft lip and palate: case report

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    Holanda, Maurus Marques de Almeida; Rocha, Artur Bastos; Santos, Rayan Haquim Pinheiro [Universidade Federal da Paraiba (UFPB), Joao Pessoa, PB (Brazil); Furtado, Paulo Germano Cavalcanti [Universidade Federal da Paraiba (UFPB), Joao Pessoa, PB (Brazil). Dept. de Pediatria e Genetica

    2011-11-15

    Association of basal sphenoethmoidal encephalocele with midline cleft lip and palate is extremely rare. The authors report the case of a nine-year-old girl presenting a midline facial cleft with meningocele that was noticeable through the palatine defect as a medial intranasal pulsatile mass. An analysis of clinical and radiological findings of the present case of cranial dysraphism is carried out. (author)

  6. Fibrous dysplasia

    Science.gov (United States)

    ... chap 22. Czerniak B. Fibrous dysplasia and related lesions. In: Czerniak B, ed. Bone Tumors. 2nd ... Assistant Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also ...

  7. An unusual variant of the common trunk of the fronto-orbital and frontopolar arteries associated with a ruptured aneurysm of the A1 segment of the anterior cerebral artery

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    Kenta Aso

    2015-01-01

    Full Text Available Background: The common trunk of the fronto-orbital artery (FOA and frontopolar artery (FPA arising from the A1 segment of the anterior cerebral artery (ACA associated with a ruptured aneurysm (AN, is rare. Case Description: The patient was a 52-year-old man who suffered from subarachnoid hemorrhage. Three-dimensional computed tomography angiography revealed an elongated and tortuous left A1 segment of the ACA and a saccular AN arising from the left A1 segment of the ACA at the origin of the cortical branch, defining its location just on the midline and behind the anterior communicating artery. This vessel had two branches. One branch ran along the inferior surface of the ipsilateral frontal lobe, and the other branch ran anteriorly and medially along the surface of the left hemisphere toward the frontal pole. The anomalous artery was interpreted as a common trunk of the FOA and FPA. Bifrontal craniotomy was performed. The anomalous artery arose from the A1 segment of the ACA at the origin of the AN, and the recurrent artery of Heubner branched off the anomalous artery. The AN was successfully obliterated, clipping with a bayonet-shaped Yasargil titanium clip. Complete AN occlusion and patency of both the A1 and the common trunk of the FOA and FPA, were confirmed intraoperatively by indocyanine green angiography. Conclusions: Recognizing this variant preoperatively, could be helpful in preventing the complications of surgery.

  8. Craniofacial fibrous dysplasia

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    Aakarsh Jhamb

    2012-01-01

    Full Text Available Fibrous dysplasia can present clinically in varied forms which may appear as collision of different pathologic processes. We report a rare case of craniofacial fibrous dysplasia with coexisting epithelial lined cyst and superimposed osteomyelitis with sequestrum formation. Its clinical features and management with possible hypotheses are described along with the post operative course. Pertinent literature has been reviewed with emphasis on pathogenesis of this unique occurrence.

  9. Strength of Fibrous Composites

    CERN Document Server

    Huang, Zheng-Ming

    2012-01-01

    "Strength of Fibrous Composites" addresses evaluation of the strength of a fibrous composite by using its constituent material properties and its fiber architecture parameters. Having gone through the book, a reader is able to predict the progressive failure behavior and ultimate strength of a fibrous laminate subjected to an arbitrary load condition in terms of the constituent fiber and matrix properties, as well as fiber geometric parameters. The book is useful to researchers and engineers working on design and analysis for composite materials. Dr. Zheng-Ming Huang is a professor at the School of Aerospace Engineering & Applied Mechanics, Tongji University, China. Mr. Ye-Xin Zhou is a PhD candidate at the Department of Mechanical Engineering, the University of Hong Kong, China.

  10. Benign Fibrous Histiocytoma

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    Pushpa Varma

    2014-01-01

    Full Text Available Fibrous histiocytomas (FHs are mesenchymal tumors that may be benign or malignant. Ocular involvement by FHs is infrequent and primarily limited to the orbit. Rarely, FHs can also involve the conjunctiva and perilimbal area. We report the case of a 38-year-old male with lid, conjunctival, and neck FHs. The diagnosis was confirmed by histopathology.

  11. Calvarial malignant fibrous histiocytoma

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    Chhabra R

    2004-07-01

    Full Text Available Primary malignant fibrous histiocytoma (MFH of the central nervous system (CNS is uncommon. We report cases of two young patients of MFH arising from the cranial meninges and involving the adjacent skull and scalp. There was infiltration of the brain in one case. Both the lesions were excised and primary scalp repair was performed.

  12. Gastric Calcifying Fibrous Tumour

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    Tan Attila

    2006-01-01

    Full Text Available Intramucosal gastric tumours are most commonly found to be gastrointestinal stromal tumours or leiomyomas (smooth muscle tumours; however, a variety of other uncommon mesenchymal tumours can occur in the stomach wall. A rare benign calcifying fibrous tumour is reported and the endoscopic appearance, ultrasound findings and morphology are documented. A review of the literature found only two similar cases.

  13. The nature of fibrous dysplasia

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    Lemmer Johan

    2009-11-01

    Full Text Available Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption.

  14. [Craniofacial fibrous dysplasia].

    Science.gov (United States)

    Couturier, A; Aumaître, O; Mom, T; Gilain, L; André, M

    2016-12-01

    Fibrous dysplasia of bone is a benign, uncommon, sporadic, congenital skeletal disorder resulting in deformity. This disease arises from activating somatic mutation in GNAS which encodes the α subunit of the G stimulatory protein associated with proliferation of undifferentiated osteogenic cells resulting in marrow fibrosis, abnormal matrix production, and stimulation of osteoclastic resorption upon overproduction of IL-6 observed in dysplastic cells. Fibrous dysplasia may be monostotic or polyostotic. This mutation affecting many tissues, café au lait skin macules and endocrinopathies (precocious puberty, hyperthyroidism, growth hormone excess, Cushing syndrome) may be associated in McCune-Albright syndrome, but also myxoma in Mazabraud syndrome or phosphate diabetes. Diagnosis of craniofacial fibrous dysplasia should be considered in the presence of headache, neuralgia, sensory disorders (vision, hearing, balance, smelling), functional disorders (nasal obstruction, nasolacrimal duct obstruction, non-matching occlusion), infectious complications (sinusitis, otitis, mastoiditis). Such symptoms should lead to perform craniofacial CT scan completed with MRI. Bone biopsy is not systematic. Surgical treatment is discussed in cases of nervous complication, facial deformity or active lesions. In case of pain resistant to conventional analgesics, intravenous bisphosphonates can be proposed. In non-responder patients, several case reports suggest the efficacy of a monoclonal antibody directed against the IL-6 receptor which requires to be confirmed by randomized studies.

  15. Solitary fibrous tumor

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    Manlio Mencoboni

    2010-12-01

    Full Text Available Solitary fibrous tumor (SFT is a rare mesenchymal neoplasm which may be found everywhere in the body. It is now distinguished into two forms, pleural and extrapleural, which morphologically resemble each other. Abdomi­nal localizations are quite rare, with 10 cases only reported in bladder; rarely they can be source of paraneoplastic syndromes (i.e., hypoglycemia secondary to insulin-like growth factor. In April 2006 a 74-year-old white male presented with chills, diaphoresis and acute abdominal pain with hematuria. At admission in emergency he underwent an abdominal X-ray (no pathological findings and an ultrasound examination of the kidneys and urinary tract, which revealed a pelvic hyperechogenic neoformation measuring approximately 10¥8¥7 cm, compressing the bladder. Blood chemistry at admission revealed only a mild neutrophilic leucocytosis (WBC 16600, N 80%, L 11%, elevated fibrinogen and ESR, and hypoglycemia (38 mg/dL. Macro­scopic hematuria was evident, while urinocolture was negative. Contrast enhanced CT scan of the abdomen and pelvic region revealed a large round neoformation dislocating the bladder, with an evident contrast-enhanced periphery and a central necrotic area. Continuous infusion of glucose 5% solution was necessary in order to maintain blood glucose levels above 50 mg/dL. The patient underwent complete surgical resection of an ovoidal mass coated by adipose tissue, with well delimited margins; histological findings were consistent with solitary fibrous tumor (SFT. Hypoglycemia resolved completely with removal of the growth. In this case report we describe a SFT growing in the bladder, a quite rare localization, which presented a unique hypoglycemia. In contrast to the majority of cases reported in the literature, the behavior of this SFT was not aggressive, and, since the patient is still alive, surgical resection was considered conclusive.

  16. Creep of fibrous composite materials

    DEFF Research Database (Denmark)

    Lilholt, Hans

    1985-01-01

    Models are presented for the creep behaviour of fibrous composite materials with aligned fibres. The models comprise both cases where the fibres remain rigid in a creeping matrix and cases where the fibres are creeping in a creeping matrix. The treatment allows for several contributions to the cr......Models are presented for the creep behaviour of fibrous composite materials with aligned fibres. The models comprise both cases where the fibres remain rigid in a creeping matrix and cases where the fibres are creeping in a creeping matrix. The treatment allows for several contributions...... such as Ni + W-fibres, high temperature materials such as Ni + Ni3Al + Cr3C2-fibres, and medium temperature materials such as Al + SiC-fibres. For the first two systems reasonable consistency is found for the models and the experiments, while for the third system too many unquantified parameters exist...

  17. Optic Nerve Decompression for Orbitofrontal Fibrous Dysplasia

    OpenAIRE

    Abe, Takumi; Sato, Kaneshige; Otsuka, Takaharu; Kawamura, Noriyoshi; Shimazu, Motohiko; Izumiyama, Hitoshi; Matsumoto, Kiyoshi

    2002-01-01

    Orbitofrontal fibrous dysplasia often involves the bony orbit and the optic canal. Although fibrous dysplasia reportedly produces compression of the optic nerve leading to visual distrubances, optic nerve decompression in patients without clinical signs of optic neuropathy is still controversial. We describe two patients with orbitofrontal fibrous dysplasia without signs of visual disturbance and one patient with McCune-Albright syndrome and progressive visual impairment. Optic nerve decompre...

  18. Oral benign fibrous histiocytoma: two case reports

    OpenAIRE

    Menditti, Dardo; Laino, Luigi; Mezzogiorno, Antonio; Sava, Sara; Bianchi, Alexander; Caruso, Giovanni; Di Maio, Luigi; Baldi, Alfonso

    2009-01-01

    Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body. The involvement of the oral cavity is rare. We report two cases of benign fibrous histiocytoma that localized in the oral cavity. The clinical and histological features of the lesion are reported. Finally, a literature revision of this pathology at the level of the oral cavity is reported.

  19. Fibrous histiocytoma of the laryngeal glottis

    Institute of Scientific and Technical Information of China (English)

    GE Pingjiang; ZHANG Baoquan; GAO Zhiqiang; Wang Hui; CUI Quancai

    2005-01-01

    A case of a fibrous histiocytoma (FH) of the larynx in a 54-year-old male is reported. Laryngeal fibrous histiocytoma is uncommon. The case recurred several times over 4-year period. Its pathology is described including arguments on potential malignancy and the way of management.

  20. Solitary Fibrous Tumor of the Stomach

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    Hussain, Qulsoom; Shafique, Khurram; Hurairah, Abu; Grossman, Evan B.

    2017-01-01

    Solitary fibrous tumor is a rare mesenchymal neoplasm that usually originates from the pleura, but has been reported in other extrapleural locations. We report a rare case of a solitary fibrous tumor of the stomach, which was successfully treated with endoscopic mucosal resection. PMID:28286800

  1. Nutritional fibrous osteodystrophy in goats

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    Paulo M Bandarra

    2011-10-01

    Full Text Available Seven out of 25 goats from a southern Brazilian flock developed nutritional fibrous osteodystrophy. Affected animals were younger than 1 year of age and were confined in stalls and fed a concentrate ration containing 1:6 calcium:phosphorus ratio. The remaining flock (35 goats was managed at pasture and showed no disease. Clinical signs were characterized by mandibular and maxillary enlargements, varying degrees of mouth opening and protruding tongue, dyspnea, apart of abnormalities of prehension and mastication. Affected animals had increased seric levels of phosphorus and parathormone, as well as higher alkaline phosphatase activity. Postmortem examination on three succumbed goats revealed bilateral enlargement of the maxilla and mandibula, and loose teeth, apart of multiple incomplete rib fractures in one of them. Severe diffuse proliferation of loose connective tissue surrounded the osteoid trabeculae, many of which were partially or completely non-mineralized. Mineralized osteoid trabeculae showed osteoclasts in the Howship's lacunae.

  2. Posttraumatic Cranial Cystic Fibrous Dysplasia

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    Arata Tomiyama

    2011-01-01

    Full Text Available A 14-year-old was girl admitted to our hospital with a subcutaneous mass of the occipital head. The mass had grown for 6 years, after she had sustained a head injury at the age of 6, and was located directly under a previous wound. Skull X-ray Photograph (xp, computed tomography (CT, and magnetic resonance imaging (MRI showed a bony defect and cystic changes in the skull corresponding to a subcutaneous mass. Bone scintigraphy revealed partial accumulation. The patient underwent total removal of the skull mass, and the diagnosis from the pathological findings of the cyst wall was fibrous dysplasia (FD. The radiographic findings for cystic cranial FD can be various. Progressive skull disease has been reported to be associated with head trauma, but the relationship between cranial FD and head trauma has not been previously reported. Previous studies have suggested that c-fos gene expression is a key mechanism in injury-induced FD.

  3. Fibrous-Ceramic/Aerogel Composite Insulating Tiles

    Science.gov (United States)

    White, Susan M.; Rasky, Daniel J.

    2004-01-01

    Fibrous-ceramic/aerogel composite tiles have been invented to afford combinations of thermal-insulation and mechanical properties superior to those attainable by making tiles of fibrous ceramics alone or aerogels alone. These lightweight tiles can be tailored to a variety of applications that range from insulating cryogenic tanks to protecting spacecraft against re-entry heating. The advantages and disadvantages of fibrous ceramics and aerogels can be summarized as follows: Tiles made of ceramic fibers are known for mechanical strength, toughness, and machinability. Fibrous ceramic tiles are highly effective as thermal insulators in a vacuum. However, undesirably, the porosity of these materials makes them permeable by gases, so that in the presence of air or other gases, convection and gas-phase conduction contribute to the effective thermal conductivity of the tiles. Other disadvantages of the porosity and permeability of fibrous ceramic tiles arise because gases (e.g., water vapor or cryogenic gases) can condense in pores. This condensation contributes to weight, and in the case of cryogenic systems, the heat of condensation undesirably adds to the heat flowing to the objects that one seeks to keep cold. Moreover, there is a risk of explosion associated with vaporization of previously condensed gas upon reheating. Aerogels offer low permeability, low density, and low thermal conductivity, but are mechanically fragile. The basic idea of the present invention is to exploit the best features of fibrous ceramic tiles and aerogels. In a composite tile according to the invention, the fibrous ceramic serves as a matrix that mechanically supports the aerogel, while the aerogel serves as a low-conductivity, low-permeability filling that closes what would otherwise be the open pores of the fibrous ceramic. Because the aerogel eliminates or at least suppresses permeation by gas, gas-phase conduction, and convection, the thermal conductivity of such a composite even at

  4. Radiation-induced intracranial malignant fibrous histiocytoma

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez-Vitale, J.C.; Slavin, R.E.; McQueen, J.D.

    1976-06-01

    An autopsy case of radiation-induced intracranial malignant fibrous histiocytoma (fibroxanthosarcoma) is reported. The tumor developed in the region of the sella turcica 11 years after high dose radiotherapy of a chromophobe adenoma of the pituitary. The tumor had infiltrated the base of the brain as well as the base of the skull. Metastases were not found. The tumor was composed of an admixture of bizarre fibroblasts, histiocytes and giant cells, xanthoma cells and siderophages, with a storiform fibrous stroma. This appears to be the first documented instance of a malignant fibrous histiocytoma occurring intracranially after local x irradiation.

  5. The "pirate sign" in fibrous dysplasia.

    Science.gov (United States)

    Singnurkar, Amit; Rush, Chris

    2006-11-01

    Fibrous dysplasia commonly involves the skull in both its monostotic and polyostotic variants. We present two cases of fibrous dysplasia involving the sphenoid wing, which were strikingly similar in their bone scan appearance. Both patients demonstrated intense increased uptake of Tc-99m MDP in a pattern reminding us of a "pirate wearing an eyepatch." We propose that this characteristic appearance of fibrous dysplasia of the sphenoid wing be called the "pirate sign." A review of the literature revealed several other pathologic conditions that have been reported to involve the sphenoid bone and should be considered in the differential diagnosis of abnormal bone tracer uptake in this region.

  6. Atypical Cutaneous Fibrous Histiocytoma: An Unusual and Misleading Variant of Fibrous Histiocytoma

    OpenAIRE

    Soumaya Ben Abdelkrim; Colondane Belajouza; Wafa Jomaa; Nadia Beizig; Zeineb Ben Said; Moncef Mokni; Rafia Nouira; Badreddine Sriha

    2011-01-01

    Atypical fibrous histiocytoma is a distinctive variant of cutaneous fibrous histiocytoma, which is often mistaken histologically for sarcoma and which have a tendency to recur locally and a capacity to metastasize, although very rarely. We report a new case of atypical cutaneous fibrous histiocytoma in a 31-year-old man who presented with a recurrent polypoid nodule on the abdominal wall. The diagnosis was made on the basis of morphological and immunohistochemical findings. We discuss through...

  7. Solitary Fibrous Tumor of the Uterus

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    Po-Wei Chu

    2006-12-01

    Conclusion: The behavior of solitary fibrous tumors arising from the uterus is difficult to evaluate; therefore, complete surgical excision featuring clear margins and comprehensive follow-up is recommended.

  8. [Solitary fibrous tumours of the kidney].

    Science.gov (United States)

    Gres, Pascal; Avances, Christophe; Ben Naoum, Kamel; Chapuis, Héliette; Costa, Pierre

    2004-02-01

    Solitary fibrous tumours (SFT) are mesenchymal tumours that usually arise from the pleura. Renal SFT are exceptional (9 cases reported in the literature). The authors report a new case discovered during assessment of HT and treated by radical right nephrectomy. The histological appearance is characteristic: a tumour with a fibrous centre, composed of a monomorphic proliferation of spindle cells, with positive CD 34, CD 99, and bcl 2 labelling. The prognosis after complete resection is generally favourable.

  9. Fibrous dysplasia of bone causing unilateral proptosis

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    Reshma Ramakrishnan

    2015-01-01

    Full Text Available Fibrous dysplasia (FD is a slow growing benign noninherited disorder in which normal bones are replaced by fibrous tissue and immature woven bones. Here we report a case of 30-year-old female who presented with unilateral proptosis and lagophthalmos without any visual loss; was diagnosed with polyostotic FD. Patient was taken up for surgery. Osseous reconturing was done by shaving of involved facial bones. Postoperatively, there was a decrease in proptosis and lagophthalmos.

  10. Fibrous dysplasia of bone: a clinicopathologic review

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    Mohan H

    2011-11-01

    Full Text Available Harsh Mohan1, Preeti Mittal1, Irneet Mundi1, Sudhir Kumar21Department of Pathology, 2Department of Orthopedics, Government Medical College, Sector 32, Chandigarh, IndiaAbstract: Fibrous dysplasia of the bones is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Its etiology has been linked to an activating mutation of Gsα and the downstream effects of the resultant increase in cAMP. Fibrous dysplasia is categorized as either monostotic or polyostotic, and may occur as a component of McCune-Albright syndrome or the rare Mazabraud syndrome. Long bones, skull bones, and ribs are the most commonly affected bones. The radiological picture is somewhat variable, including a ground-glass appearance, expansion of the bone, and sclerosis surrounding the lesion. Histologically, fibrous dysplasia shows irregularly-shaped trabeculae of immature, woven bone in a background of variably cellular, loosely arranged fibrous stroma. It may be complicated by pathologic fracture, and rarely by malignant transformation. This review examines interesting issues surrounding the etiology of fibrous dysplasia, its clinical and laboratory manifestations, radiological picture, utility of bone biopsy, gross and microscopic pathology, complications, and its differential diagnostic considerations.Keywords: fibrous dysplasia, McCune-Albright syndrome, monostotic form, polyostotic form

  11. Fibrous Dysplasia Characterization Using Lacunarity Analysis.

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    Cordeiro, Mirna S; Backes, André R; Júnior, Antônio F Durighetto; Gonçalves, Elmar H G; de Oliveira, Jefferson X

    2016-02-01

    Fibrous dysplasia (FD) is a developmental anomaly in which the normal medullary space of the affected bone is replaced by fibro-osseous tissue. This condition is typically encountered in adolescents and young adults. It affects the maxillofacial region and it can often cause severe deformity and asymmetry. Therefore, accurate diagnosis is critical to determine the appropriate treatment of each case. In this sense, computed tomography (CT) is a relevant resource among the imaging techniques for correct diagnosis of this condition. Thus, in this paper, we propose to analyze fibrous dysplasia through its texture pattern. To accomplish this task, we propose to use lacunarity analysis, a multiscale method for describing patterns of spatial dispersion. Results indicated lower lacunarity values for fibrous dysplasia in comparison to normal bone samples, an indication that their texture images are more homogeneous, and a high separability between the classes when using principal component analysis (PCA) and decision trees for statistical analysis.

  12. Congenital fibrous hamartoma of the knee

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    Arioni, Cesare; Bellini, Carlo; Risso, Francesco Maria; Scopesi, Fabio; Serra, Giovanni [University of Genoa, Neonatal Pathology Service, Department of Paediatrics, Institute G. Gaslini, Genoa (Italy); Oddone, Mauro; Toma, Paolo [Institute G. Gaslini, Radiology Service, Genoa (Italy); Nozza, Paolo [Institute G. Gaslini, U. O. di Anatomia Patologica, Genoa (Italy)

    2006-05-15

    A full-term male infant presented at birth with a hard swelling of the left knee. The lemon-sized lesion was fixed to the underlying knee muscles, while the overlying skin was stretched and shiny; there was no bruit. Radiography, sonography and MRI suggested a soft-tissue tumour. After surgical excision, histology showed the presence of fibrous and mesenchymal tissue, with mature adipose tissue. Fibrous hamartoma of infancy was diagnosed. Among soft-tissue tumours, fibrous hamartoma of infancy is a rare and benign lesion, occurring in the first 2 years of life. The tumour mainly affects the trunk, axilla, and upper extremities. This infant had unique involvement of the knee. The treatment of choice is local excision. (orig.)

  13. Malignant fibrous histiocytoma with skeletal involvement

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    Takechi,Hideo

    1978-10-01

    Full Text Available Malignant fibrous histiocytoma of soft part is rather common but malignant fibrous histiocytoma of the bone is rarely encountered clinically. Authors present five cases of malignant fibrous histiocytoma with skeletal involvement and discuss their clinical course, x-ray findings and histological features. This tumor has marked tendency for local recurrence and metastasis. Other bone tumors such as giant cell tumor, aneurysmal bone cyst, non ossifying fibroma, osteosarcoma, fibrosarcoma of bone and metastatic cancer can be excluded by several characteristic findings observed in x-rays as well as histopathological features. All information on the patient should be carefully analysed, because it is difficult to decide whether bone involvement is primary or secondary. Four out of five cases definitely originated within the bone.

  14. Fibrous Protein Structures: Hierarchy, History and Heroes.

    Science.gov (United States)

    Squire, John M; Parry, David A D

    2017-01-01

    During the 1930s and 1940s the technique of X-ray diffraction was applied widely by William Astbury and his colleagues to a number of naturally-occurring fibrous materials. On the basis of the diffraction patterns obtained, he observed that the structure of each of the fibres was dominated by one of a small number of different types of molecular conformation. One group of fibres, known as the k-m-e-f group of proteins (keratin - myosin - epidermin - fibrinogen), gave rise to diffraction characteristics that became known as the α-pattern. Others, such as those from a number of silks, gave rise to a different pattern - the β-pattern, while connective tissues yielded a third unique set of diffraction characteristics. At the time of Astbury's work, the structures of these materials were unknown, though the spacings of the main X-ray reflections gave an idea of the axial repeats and the lateral packing distances. In a breakthrough in the early 1950s, the basic structures of all of these fibrous proteins were determined. It was found that the long protein chains, composed of strings of amino acids, could be folded up in a systematic manner to generate a limited number of structures that were consistent with the X-ray data. The most important of these were known as the α-helix, the β-sheet, and the collagen triple helix. These studies provided information about the basic building blocks of all proteins, both fibrous and globular. They did not, however, provide detailed information about how these molecules packed together in three-dimensions to generate the fibres found in vivo. A number of possible packing arrangements were subsequently deduced from the X-ray diffraction and other data, but it is only in the last few years, through the continued improvements of electron microscopy, that the packing details within some fibrous proteins can now be seen directly. Here we outline briefly some of the milestones in fibrous protein structure determination, the role of the

  15. Enzymes in bast fibrous plant processing.

    Science.gov (United States)

    Kozlowski, Ryszard; Batog, Jolanta; Konczewicz, Wanda; Mackiewicz-Talarczyk, Maria; Muzyczek, Malgorzata; Sedelnik, Natalia; Tanska, Bogumila

    2006-05-01

    The program COST Action 847 Textile Quality and Biotechnology (2000-2005) has given an excellent chance to review the possibilities of the research, aiming at development of the industrial application of enzymes for bast fibrous plant degumming and primary processing. The recent advancements in enzymatic processing of bast fibrous plants (flax, hemp, jute, ramie and alike plants) and related textiles are given. The performance of enzymes in degumming, modification of bast fibres, roving, yarn, related fabrics as well as enzymatic bonding of lignocellulosic composites is provided.

  16. A case of intracranial malignant fibrous histiocytoma

    Directory of Open Access Journals (Sweden)

    Amir Hossein Sarrami

    2011-01-01

    Full Text Available We describe a case of intracranial malignant fibrous histiocytoma which had infiltrated pons, cerebellum and basal surface of left temporal lobe without any visible mass. The patient presented with a sudden loss of consciousness and vomiting. Clinical findings, laboratory tests, imaging and examination of the cerebrospinal fluid tended to establish the diagnosis of an infectious condition than a malignancy. Without any response to the antibiotics and with a progressive deterioration of neurologic and mental condition, the patient died after 20 days. In the autopsy, histological and immunohistochemical study of the brain revealed the diagnosis of malignant fibrous histiocytoma (MFH.

  17. Atypical cutaneous fibrous histiocytoma: an unusual and misleading variant of fibrous histiocytoma.

    Science.gov (United States)

    Ben Abdelkrim, Soumaya; Belajouza, Colondane; Jomaa, Wafa; Beizig, Nadia; Ben Said, Zeineb; Mokni, Moncef; Nouira, Rafia; Sriha, Badreddine

    2011-01-01

    Atypical fibrous histiocytoma is a distinctive variant of cutaneous fibrous histiocytoma, which is often mistaken histologically for sarcoma and which have a tendency to recur locally and a capacity to metastasize, although very rarely. We report a new case of atypical cutaneous fibrous histiocytoma in a 31-year-old man who presented with a recurrent polypoid nodule on the abdominal wall. The diagnosis was made on the basis of morphological and immunohistochemical findings. We discuss through this case and a review of the literature pathological and evolutive features and diagnostic difficulties of this entity.

  18. Atypical Cutaneous Fibrous Histiocytoma: An Unusual and Misleading Variant of Fibrous Histiocytoma

    Directory of Open Access Journals (Sweden)

    Soumaya Ben Abdelkrim

    2011-01-01

    Full Text Available Atypical fibrous histiocytoma is a distinctive variant of cutaneous fibrous histiocytoma, which is often mistaken histologically for sarcoma and which have a tendency to recur locally and a capacity to metastasize, although very rarely. We report a new case of atypical cutaneous fibrous histiocytoma in a 31-year-old man who presented with a recurrent polypoid nodule on the abdominal wall. The diagnosis was made on the basis of morphological and immunohistochemical findings. We discuss through this case and a review of the literature pathological and evolutive features and diagnostic difficulties of this entity.

  19. Clinicopathologic characteristics of fibrous mass-forming chronic pancreatitis

    Institute of Scientific and Technical Information of China (English)

    常雪姣

    2013-01-01

    Objective To investigate clinicopathological features of fibrous mass-forming chronic pancreatitis (FMCP) ,to compare clinicopathological and immunohistochemical characteristics between autoimmune pancreatitis (AIP) and fibrous mass-forming non-autoimmune pancreatitis

  20. Cervical spinal monostotic fibrous dysplasia: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ok Hwa [Dept. of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan (Korea, Republic of)

    2013-09-15

    Monostotic fibrous dysplasia of the cervical vertebra is quite unusual. The author reports a case of monostotic fibrous dysplasia affecting the second cervical vertebra with descriptions from the CT, MR and bone scanning findings.

  1. Optic nerve decompression for orbitofrontal fibrous dysplasia.

    Science.gov (United States)

    Abe, Takumi; Sato, Kaneshige; Otsuka, Takaharu; Kawamura, Noriyoshi; Shimazu, Motohiko; Izumiyama, Hitoshi; Matsumoto, Kiyoshi

    2002-08-01

    Orbitofrontal fibrous dysplasia often involves the bony orbit and the optic canal. Although fibrous dysplasia reportedly produces compression of the optic nerve leading to visual distrubances, optic nerve decompression in patients without clinical signs of optic neuropathy is still controversial. We describe two patients with orbitofrontal fibrous dysplasia without signs of visual disturbance and one patient with McCune-Albright syndrome and progressive visual impairment. Optic nerve decompression was performed prophylactically for two patients and therapeutically for one patient through the transcranial extradural route. Dystopias and craniofacial deformities induced by fibrous dysplasia also were corrected. The micropressure suction-irrigation system was especially effective for decreasing heat transfer and thereby preventing thermal injury of the optic nerve. The orbitofrontal area was reconstructed from cranial bone, iliac bone, and ribs. Postoperative follow-up revealed no disturbances in visual function and no evidence of cerebrospinal fluid leakage. These findings suggest that optic nerve decompression may be effective in preventing visual disturbances with minimal risk of other neurological sequelae. Subsequent orbital reconstruction yielded satisfactory cosmetic results.

  2. Prophylactic intramedullary nailing in monostotic fibrous dysplasia.

    Science.gov (United States)

    Demiralp, Bahtiyar; Ozturk, Cagatay; Ozturan, Kutay; Sanisoglu, Yavuz S; Cicek, Ilker E; Erler, Kaan

    2008-06-01

    Fibrous dysplasia of bone is an enigma with no known cure. Treatment currently consists of curettage and bone-grafting in an attempt to eradicate the lesion and to prevent progressive deformity. This study presents the results of prophylactic intramedullary nailing in 10 patients with monostotic fibrous dysplasia, pain increasing with movement, and scintigraphically established activity. Ten patients with monostotic fibrous dysplasia in their upper or lower extremities treated between 2001 and 2003 were included in the study. Seven patients were male and 3 were female; their mean age was 26.9 years. The mean duration of follow-up was 33.5 months. Closed intramedullary nail without reaming was used in all cases. Bone grafting was not performed. Patients were allowed full weight bearing on the affected extremities on the second postoperative day. Mean VAS for functional pain was 5.33 +/- 0.65 preoperatively and 2.26 +/- 0.57 at final follow-up (p < 0.05). Radiographs showed no changes in lesion size, and the intramedullary fixation appeared to be stable. Prophylactic intramedullary nailing appeared to be beneficial in monostotic fibrous dysplasia with scintigraphically proven activity and functional pain. It also avoids problems that may occur following pathological fracture.

  3. Giant solitary fibrous tumour of the liver

    NARCIS (Netherlands)

    T. Terkivatan (Türkan); M. Kliffen (Mike); J.H.W. de Wilt (Johannes); A.N. van Geel (Albert); A.M.M. Eggermont (Alexander); C. Verhoef (Kees)

    2006-01-01

    textabstractBackground: Solitary fibrous tumour (SFT) is an uncommon mesenchymal neoplasm that most frequently affects the pleura, although it has been reported with increasing frequency in various other sites such as in the peritoneum, pericardium and in non-serosal sites such as lung parenchyma,

  4. Craniofacial fibrous dysplasia: A 10-case series.

    Science.gov (United States)

    Couturier, A; Aumaître, O; Gilain, L; Jean, B; Mom, T; André, M

    2017-09-01

    Fibrous dysplasia of bone is a rare sporadic benign congenital condition in which normal cancellous bone is replaced by fibro-osseous tissue with immature osteogenesis. Sarcomatous transformation is exceptional. Lesions may involve one bone (monostotic) or several (polyostotic). Fibrous dysplasia may be associated with café-au-lait skin macules and endocrinopathy in McCune-Albright syndrome, or with myxoma in Mazabraud's syndrome. We report ten cases of patients followed up for craniofacial fibrous dysplasia in our center between 2010 and 2015. Mean age was 43 years (range, 10-72 years). Clinical symptoms comprised headache (n=3) and sensorineural disorder: recurrent anterior uveitis (n=1), visual acuity loss, epiphora and vestibular syndrome (n=1), and hearing loss (n=1). All cases were monostotic. The sphenoid bone was most commonly involved (n=5), followed by the ethmoid (n=1), frontal (n=1), fronto-ethmoid (n=1), temporal (n=1) and fronto-ethmoido-sphenoid (n=1) bones. Five patients were treated with intravenous pamidronate, a bisphosphonate: evolution was favorable for 3 of them at 1-6 months after treatment initiation, with resolution of headache or vestibular syndrome; the other 2 patients were stable. Two patients were operated on. Diagnosis of craniofacial fibrous dysplasia should be considered in case of headache, neuralgia, sensory disorder, functional disorder or infectious ENT complications. A medico-surgical approach is useful for these patients. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  5. Solitary fibrous tumour of the vagus nerve.

    Science.gov (United States)

    Scholsem, Martin; Scholtes, Felix

    2012-04-01

    We describe the complete removal of a foramen magnum solitary fibrous tumour in a 36-year-old woman. It originated on a caudal vagus nerve rootlet, classically described as the 'cranial' accessory nerve root. This ninth case of immunohistologically confirmed cranial or spinal nerve SFT is the first of the vagus nerve.

  6. POROSITY CALCULATION OF MIXTURES OF FIBROUS PARTICLES

    Institute of Scientific and Technical Information of China (English)

    Ruping Zou; Aibing Yu

    2003-01-01

    The initial forming of fiber blend to high green density, i.e. the packing of fibrous particles, is important to the reinforcement of composite materials. It is very useful to develop a general predictive method for the optimum selection of particle mixtures for the property control of ceramic or composite products. This paper presents such a mathematical model developed on the basis of the similarity analysis between the spherical and non-spherical particle packings and assesses its applicability to the packing of fibrous particles with discrete and/or continuous length distributions. The results indicate that the model can predict this packing system well and hence provide an effective way to solve various packing problems in the composite materials processing.

  7. Protease-degradable electrospun fibrous hydrogels

    Science.gov (United States)

    Wade, Ryan J.; Bassin, Ethan J.; Rodell, Christopher B.; Burdick, Jason A.

    2015-03-01

    Electrospun nanofibres are promising in biomedical applications to replicate features of the natural extracellular matrix (ECM). However, nearly all electrospun scaffolds are either non-degradable or degrade hydrolytically, whereas natural ECM degrades proteolytically, often through matrix metalloproteinases. Here we synthesize reactive macromers that contain protease-cleavable and fluorescent peptides and are able to form both isotropic hydrogels and electrospun fibrous hydrogels through a photoinitiated polymerization. These biomimetic scaffolds are susceptible to protease-mediated cleavage in vitro in a protease dose-dependent manner and in vivo in a subcutaneous mouse model using transdermal fluorescent imaging to monitor degradation. Importantly, materials containing an alternate and non-protease-cleavable peptide sequence are stable in both in vitro and in vivo settings. To illustrate the specificity in degradation, scaffolds with mixed fibre populations support selective fibre degradation based on individual fibre degradability. Overall, this represents a novel biomimetic approach to generate protease-sensitive fibrous scaffolds for biomedical applications.

  8. Nonlinear mechanics of soft fibrous materials

    CERN Document Server

    Ogden, Raymond

    2015-01-01

    The book presents a state-of-the-art overview of the fundamental theories, established models and ongoing research related to the modeling of these materials. Two approaches are conventionally used to develop constitutive relations for highly deformable fibrous materials. According to the phenomenological approach, a strain energy density function can be defined in terms of strain invariants. The other approach is based on kinetic theories, which treats a fibrous material as a randomly oriented inter-tangled network of long molecular chains bridged by permanent and temporary junctions. At the micro-level, these are associated with chemical crosslinks and active entanglements, respectively. The papers include carefully crafted overviews of the fundamental formulation of the three-dimensional theory from several points of view, and address their equivalences and differences. Also included are solutions to boundary-value problems which are amenable to experimental verification. A further aspect is the elasticity...

  9. First description of Phanerozoic radiaxial fibrous dolomite

    Science.gov (United States)

    Richter, D. K.; Heinrich, F.; Geske, A.; Neuser, R. D.; Gies, H.; Immenhauser, A.

    2014-05-01

    The petrographic analysis and crystallographic analysis of concretionary carbonate cements ("coal balls") from Carboniferous paralic swamp deposits reveal the presence of (length fast) radiaxial fibrous dolomite (RFD), a fabric not previously reported from the Phanerozoic. This finding is of significance as earlier reports of Phanerozoic radiaxial fibrous carbonates are exclusively of calcite mineralogy. Dolomite concretions described here formed beneath marine transgressive intervals within palustrine coal seams. This is of significance as seawater was arguably the main source of Mg2 + ions for dolomite formation. Here, data from optical microscopy, cathodoluminescence, electron backscattered diffraction, X-ray diffraction and geochemical analyses are presented to characterize three paragenetic dolomite phases and one calcite phase in these concretions. The main focus is on the earliest diagenetic, non-stoichiometric (degree of order: 0.41-0.46) phase I, characterized by botryoidal dolomite constructed of fibres up to 110 μm wide with a systematic undulatory extinction and converging crystal axes. Petrographic and crystallographic evidence clearly qualifies phase I dolomite as radiaxial fibrous. Conversely, fascicular optical fabrics were not found. Carbon-isotope ratios (δ13C) are depleted (between - 11.8 and - 22.1‰) as expected for carbonate precipitation from marine pore-fluids in organic-matter-rich, paralic sediment. Oxygen isotope (δ18O) ratios range between - 1.3 and - 6.0‰. The earliest diagenetic nature of these cements is documented by the presence of ubiquitous, non-compacted fossil plant remains encased in phase I dolomite as well as by the complex zoned luminescence patterns in the crystals and is supported by crystallographic and thermodynamic considerations. It is argued that organic matter, and specifically carboxyl groups, reduced thermodynamic barriers for dolomite formation and facilitated Mg/CaCO3 precipitation. The data shown here

  10. High surface area fibrous silica nanoparticles

    KAUST Repository

    Polshettiwar, Vivek

    2014-11-11

    Disclosed are high surface area nanoparticles that have a fibrous morphology. The nanoparticles have a plurality of fibers, wherein each fiber is in contact with one other fiber and each fiber has a length of between about 1 nm and about 5000 nm. Also disclosed are applications of the nanoparticles of the present invention, and methods of fabrication of the nanoparticles of the present invention.

  11. Monostotic fibrous dysplasia with Raynaud's phenomenon.

    Science.gov (United States)

    Kumar, K V S Hari; Aravinda, K; Narayanan, K

    2015-01-01

    Fibrous dysplasia (FD) is a benign bone disorder characterized by alteration in bone morphology. Monostotic FD is the commonest variant and affects the craniofacial bones. Raynaud's phenomenon is recurrent vasospasm of the fingers and toes due to cold exposure. The disease is usually idiopathic or secondary to connective tissue disorders. Raynaud's phenomenon is not described previously with FD. We recently encountered two interesting patients of craniofacial monostotic FD with Raynaud's phenomenon and report the same in this report.

  12. Malignant fibrous histiocytoma of the abdominal wall

    OpenAIRE

    Arif Aslaner; Burhan Mayir; Tuğrul Çakır; Umut Rıza Gündüz; Nurullah Bülbüller

    2015-01-01

    Malignant fibrous histiocytoma (MFH) or undifferentiated pleomorphic sarcoma is a type of malignt neoplasm that arises from any soft tissue and bone involving extremities, abdomen and retroperitoneum. MFH of the external oblique abdominis muscle is rare. Surgical resection of the mass is the treatment of choice depending on the stage of the disease and the invasion depth of the tumor. Radiotherapy, chemotherapy and immunotherapy are the other treatment methods. We present a case of a 71-year ...

  13. A Case of Extensive polyostotic fibrous dysplasia

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Hwang, Eui Hwan; Lee, Sang Rae [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Kyunghee University, Seoul (Korea, Republic of)

    2000-06-15

    Fibrous dysplasia is a benign disorder of bone consisting of intramedullary proliferation of fibrous tissue and irregularly distributed, poorly developed bone. The disease manifests itself in the monostotic form in which only one bone is involved and the polyostotic form in which multiple bones at different sites are affected. We reported a extensive case of polyostotic fibrous dysplasia with involvement of craniofacial bones, mandible, ribs, extremities. A 18-year-old man showed remarkable right facial swelling who had been treated on right femur 3 years ago with a bone graft for pathologic fracture and he recognized facial swelling 5 years ago. Extraoral radiograms and computed tomogram showed diffuse sclerosis with a ground glass appearance of the most calvarial bones, facial bones. The right mandibular lesion showed very expansible lesion with mottled appearance. Bone scans showed multifocal increased uptakes in craniofacial bones, right mandible, bilaterally in ribs, humerus, femur, tibia and characteristic various deformity of right femur (shepherd's crook deformity). This case showed exceptionally bilateral, extensive nature of bone lesion and didn't show any features of skin pigmentation and endocrine disturbances.

  14. Toxicity and Carcinogenicity Mechanisms of Fibrous Antigorite

    Directory of Open Access Journals (Sweden)

    Michael Balazy

    2007-03-01

    Full Text Available We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpentinite rocks found abundantly in the Western Alps. Particles containing antigorite are more abundant in the breathing air of this region than those typically found in urban ambient air. Exposure of MeT-5A and J774 cells to fibrous antigorite at concentrations of 5-100 μg/ml for 72 hr induced dose-dependent cytotoxicity. Antigorite also stimulated the ROS production, induced the generation of nitrite and PGE2. MeT-5A cells were more sensitive to antigorite than J774 cells. The results of this study revealed that the fibrous antigorite stimulates cyclooxygenase and formation of hydroxyl and nitric oxide radicals. These changes represent early cellular responses to antigorite fibers, which lead to a host of pathological and neoplastic conditions because free radicals and PGE2 play important roles as mediators of tumor pathogenesis. Understanding the mechanisms of the cellular responses to antigorite and other asbestos particles should be helpful in designing rational prevention and treatment approaches.

  15. Fibrous zinc anodes for high power batteries

    Science.gov (United States)

    Zhang, X. Gregory

    This paper introduces newly developed solid zinc anodes using fibrous material for high power applications in alkaline and large size zinc-air battery systems. The improved performance of the anodes in these two battery systems is demonstrated. The possibilities for control of electrode porosity and for anode/battery design using fibrous materials are discussed in light of experimental data. Because of its mechanical integrity and connectivity, the fibrous solid anode has good electrical conductivity, mechanical stability, and design flexibility for controlling mass distribution, porosity and effective surface area. Experimental data indicated that alkaline cells made of such anodes can have a larger capacity at high discharging currents than commercially available cells. It showed even greater improvement over commercial cells with a non-conventional cell design. Large capacity anodes for a zinc-air battery have also been made and have shown excellent material utilization at various discharge rates. The zinc-air battery was used to power an electric bicycle and demonstrated good results.

  16. Malignant transformation of fibrous dysplasia into chondroblastic osteosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Kaushik, Shaifali [Department of Radiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA (United States); Department of Radiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA (United States); Smoker, Wendy R.K. [Department of Radiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA (United States); Frable, William J. [Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA (United States)

    2002-02-01

    A case of malignant transformation of polyostotic fibrous dysplasia into maxillary chondroblastic osteosarcoma is presented. The clinical, radiographic, CT, MR imaging features and pathological findings of polyostotic fibrous dysplasia and its malignant transformation are described. Malignant transformation of fibrous dysplasia is rare and has not previously been described in the English literature in this location in McCune-Albright syndrome and in the absence of radiation treatment. (orig.)

  17. Fibrous dysplasia. Clinical review and therapeutic management.

    Science.gov (United States)

    Florez, Helena; Peris, Pilar; Guañabens, Núria

    2016-12-16

    Fibrous dysplasia is a skeletal disorder that is associated with a wide spectrum of clinical manifestations, including localized asymptomatic forms and extensive severe forms with severe bone deformities and endocrinological alterations, depending on age, location, extent and associated processes. Although the treatment of choice is based on bisphosphonates, the therapeutic efficacy of these agents in the control of disease activity remains uncertain. This article reviews the current data available on the treatment of this disease as well as the preliminary data on new therapeutic approaches. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  18. Compressibility of air in fibrous materials

    DEFF Research Database (Denmark)

    Tarnow, Viggo

    1996-01-01

    The dynamic compressibility of air in fibrous materials has been computed for two assumed configurations of fibers which are close to the geometry of real fiber materials. Models with parallel cylinders placed in a regular square lattice and placed randomly are treated. For these models...... the compressibility is computed approximately from the diameter and mean distances between cylinders. This requires calculation of the air temperature, which is calculated for cylinders in a regular lattive by the Wigner-Seitz cell approximation. In the case of random placement, the calculation is done by a summation...

  19. [Solitary naso-sinusal fibrous tumor].

    Science.gov (United States)

    Martínez, V; Jiménez, M L; Cuatrecasas, M; Jürgens, A; de Amesti, C; Orus, C; Fabra, J M

    1995-01-01

    Here we present two clinical cases of solitary naso-sinusal fibrous tumour. This tumour has a mesenchymal origin and has an evident pleural location, with well defined immunohistochemical and ultrastructural characteristics. The clinical manifestation is an apparent benign tumour with an inclination to local aggressiveness. The most effective treatment seems to be surgical removal, but given the low number of cases mentioned (there are only eight cases reported in international literature), and the tendency to eventual recurrence, called for cobalt therapy after surgery. The evolution of clinical cases is irregular.

  20. Angiomatoid fibrous histiocytoma: novel MR imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, Salutario J.; Vinson, Emily N. [Duke University Medical Center, Department of Radiology, Durham, NC (United States); Moreno, Courtney Coursey [Emory University School of Medicine, Department of Radiology and Imaging Sciences, Atlanta, GA (United States); Dodd, Leslie G. [University of North Carolina School of Medicine, Department of Pathology and Laboratory Medicine, Chapel Hill, NC (United States); Brigman, Brian E. [Duke University Medical Center, Department of Orthopedic Surgery, Durham, NC (United States)

    2016-05-15

    To describe novel MR imaging features, and clinical characteristics of soft tissue angiomatoid fibrous histiocytoma (AFH) at presentation, local recurrence, and metastases. We described the MRI findings of six cases of histologically proven AFH. Pathologic findings, clinical presentation, and outcome were reviewed. Lesions were primarily cystic. At initial presentation, tumors were surrounded by low signal intensity fibrous pseudocapsule. High signal intensity consistent with the lymphoplasmacytic infiltrate was seen in T2-weighted and post-contrast images as a rim over the hypointense pseudocapsule (double rim sign). High signal intensity infiltrating tumoral cords extended into adjacent tissues, through pseudocapsular defects on T2-weighted and post-contrast images. The cystic component and tumor cell nodularity were demonstrated at post-contrast images. Clinically, lesions were often thought to be benign, underwent marginal resection, developed local recurrence, and one developed second recurrence consisting of metastases. Recurrent tumors appeared as multiple masses, misinterpreted as post-surgical changes. An intramuscular recurrence demonstrated double rim and infiltrating margin. A predominantly well-circumscribed, primarily cystic mass with double-rim and marginal infiltration on MRI suggests the possibility of AFH, in particular in child or young adult. Inclusion of these novel observations in AFH differential diagnosis may have a significant impact on treatment and prevention of recurrence. (orig.)

  1. Self-Organization of Bioinspired Fibrous Surfaces

    Science.gov (United States)

    Kang, Sung Hoon

    Nature uses fibrous surfaces for a wide range of functions such as sensing, adhesion, structural color, and self-cleaning. However, little is known about how fiber properties enable them to self-organize into diverse and complex functional forms. Using polymeric micro/nanofiber arrays with tunable properties as model systems, we demonstrate how the combination of mechanical and surface properties can be harnessed to transform an array of anchored nanofibers into a variety of complex, hierarchically organized dynamic functional surfaces. We show that the delicate balance between fiber elasticity and surface adhesion plays a critical role in determining the shape, chirality, and hierarchy of the assembled structures. We further report a strategy for controlling the long-range order of fiber assemblies by manipulating the shape and movement of the liquid-vapor interface. Our study provides fundamental understanding of the pattern formation by self-organization of bioinspired fibrous surfaces. Moreover, our new strategies offer a foundation for designing a vast assortment of functional surfaces with adhesive, optical, water-repellent, capture and release, and many more capabilities with the structural and dynamic sophistication of their biological counterparts.

  2. Geometrical modeling of fibrous materials under compression

    Science.gov (United States)

    Maze, Benoit; Tafreshi, Hooman Vahedi; Pourdeyhimi, Behnam

    2007-10-01

    Many fibrous materials such as nonwovens are consolidated via compaction rolls in a so-called calendering process. Hot rolls compress the fiber assembly and cause fiber-to-fiber bonding resulting in a strong yet porous structure. In this paper, we describe an algorithm for generating three dimensional virtual fiberwebs and simulating the geometrical changes that happen to the structure during the calendering process. Fibers are assumed to be continuous filaments with square cross sections lying randomly in the x or y direction. The fibers are assumed to be flexible to allow bending over one another during the compression process. Lateral displacement is not allowed during the compaction process. The algorithm also does not allow the fibers to interpenetrate or elongate and so the mass of the fibers is conserved. Bending of the fibers is modeled either by considering a constant "slope of bending" or constant "span of bending." The influence of the bending parameters on the propagation of compression through the material's thickness is discussed. In agreement with our experimental observations, it was found that the average solid volume fraction profile across the thickness becomes U shaped after the calendering. The application of these virtual structures in studying transport phenomena in fibrous materials is also demonstrated.

  3. Solitary fibrous tumor surrounding the carotid sheath.

    Science.gov (United States)

    Gómez-Oliveira, Guillermo; Alvarez-Flores, Modesto; Arribas-García, Ignacio; Martínez-Gimeno, Carlos

    2010-03-01

    Solitary fibrous tumors (SFTs) are rare spindle cell neoplasms that are mostly found arising from the pleura. Although SFTs recently have been reported in other regions, they are rare in the head and neck and have often been misdiagnosed due to their rarity. SFTs are benign in most cases. Clinically, SFTs usually manifest as well-circumscribed, slow-growing, smooth and painless masses. Symptoms are often minimal, although they may include sore throat, difficulty in swallowing, change of voice or trismus. CT-Scan and MRI are the most sensitive imaging procedures used. The treatment of choice is complete surgical excision of the lesion. Because recurrences have been noted up to 30 years after surgery, long-term follow up is mandatory. In this article, we present a case of a Solitary Fibrous Tumor arising in the parapharyngeal space in a 20-year-old man, involving the carotid sheath, treated by surgical excision with no recurrence after 1 year. The clinical presentation, surgical management and pathological findings are described.

  4. Fibrous microcapsules and methods of assembly and use thereof

    Energy Technology Data Exchange (ETDEWEB)

    Stupp, Samuel; Rozkiewicz, Dorota

    2015-01-27

    The present invention relates to assembly of peptide amphiphiles and biopolymers into fibrous microcapsules, and uses thereof. In particular, the present invention provides devices, compositions, and methods for interfacial self-assembly of peptide amphiphiles and biopolyments into fibrous microcapsules, and uses thereof.

  5. Marfan syndrome with multiseptate pneumothorax and mandibular fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Kate A

    2009-01-01

    Full Text Available We describe a rare case of pneumothorax due to Marfan syndrome associated with fibrous dysplasia of the mandible. Marfan syndrome and fibrous dysplasia were possibly due to a common etiological factor. The association between the two and other tumors described in literature related to Marfan syndrome is discussed.

  6. Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications

    Science.gov (United States)

    Padmaraj, O.; Rao, B. Nageswara; Jena, Paramananda; Venkateswarlu, M.; Satyanarayana, N.

    2014-04-01

    Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl2O4)] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF6 in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl2O4 exhibits high ionic conductivity of 2.80 × 10-3 S/cm at room temperature. The charge-discharge capacity of Li/LiCoO2 coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl2O4] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator.

  7. A solitary fibrous tumor of the kidney

    Directory of Open Access Journals (Sweden)

    Anuruddha M Abeygunasekera

    2015-01-01

    Full Text Available A solitary fibrous tumor (SFT is an uncommon spindle cell neoplasm that usually occurs in the pleura, but may occur in extrapleural sites. Its occurrence in the kidney is rare. We report a SFT, clinically thought to be a renal cell carcinoma arising in the kidney of a 68-year-old female. The tumor was well-circumscribed and composed of a mixture of spindle cells and dense collagenous bands. Immunohistochemical studies revealed reactivity for CD34, CD99, and Bcl-2 protein, with no staining for keratin or muscle markers, confirming the diagnosis. The immunohistochemical study was the key to diagnosis. Several younger members of her family had colorectal and lung cancers suggesting the possibility of a familial or genetic susceptibility.

  8. Malignant fibrous histiocytoma of the abdominal wall

    Directory of Open Access Journals (Sweden)

    Arif Aslaner

    2015-01-01

    Full Text Available Malignant fibrous histiocytoma (MFH or undifferentiated pleomorphic sarcoma is a type of malignt neoplasm that arises from any soft tissue and bone involving extremities, abdomen and retroperitoneum. MFH of the external oblique abdominis muscle is rare. Surgical resection of the mass is the treatment of choice depending on the stage of the disease and the invasion depth of the tumor. Radiotherapy, chemotherapy and immunotherapy are the other treatment methods. We present a case of a 71-year old man with the diagnosis of MFH on external oblique muscle which was completely resected. We believe that adjuvant chemoradiotherapy following surgical resection of the tumor was the most appropriate treatment for this disease.

  9. Cutaneous changes in fibrous hamartoma of infancy

    Directory of Open Access Journals (Sweden)

    Pilar F-Eire

    2013-01-01

    Full Text Available Only a few published case of fibrous hamartoma of infancy (FHI have commented on the changes in the overlying skin. There are descriptions of individual cases with cutaneous hyperpigmentation, hypertrichosis and hyperhidrosis. It is interesting to describe our case because, to our knowledge, the altered pigmentation of the overlying skin, with hairs on the surface, and eccrine gland hyperplasia combined with abortive hair follicles has not been reported together in association with the FHI. We recommend that all the biopsies must be excisional including overlying skin, thus the epidermal and dermal adnexal changes can be assessed in the microscopic evaluation which could have relevant implications from clinical and embryological point of view.

  10. [Non-ossifying fibroma (metaphyseal fibrous defect)].

    Science.gov (United States)

    Rogozhin, D V; Konovalov, D M; Kozlov, A S; Talalaev, A G; Ektova, A P

    2016-01-01

    Non-ossifying fibroma (NOF) or metaphyseal fibrous defect (MFD) is benign fibroblast proliferation with the presence of osteoclast-like multinucleated giant cells. The most cases of NOF/MFD occur in the metaphysis of the long tubular bones of the lower extremities, more commonly in the metaphysis of the femur and in the proximal metaphysis of the tibia. This lesion has a characteristic X-ray pattern and requires no surgical intervention, except for cases of a pathologic fracture or a risk for the latter. The paper analyzes 35 NOF/MFD cases in children and adolescents. It has been found that one and all patients have undergone surgery, suggesting the low awareness of this abnormality among radiodiagnosticians, pathologists, and surgeons.

  11. Symptomatic fibrous lunato-triquetral coalition

    Energy Technology Data Exchange (ETDEWEB)

    Staebler, A.; Glaser, C.; Reiser, M. [Department of Diagnostic Radiology, Ludwig Maximilians University of Munich (Germany); Resnick, D. [Department of Radiology, Veterans Administration Medical Center, San Diego, CA (United States)

    1999-10-01

    In general, carpal coalitions are considered to be asymptomatic. Incomplete separated joints and associated changes similar to osteoarthritis and pseudoarthrosis are known as possible causes of wrist pain. We present the clinical history, plain-film, and MR imaging findings of two patients with symptomatic fibrous lunato-triquetral coalition. Conventional films disclosed a narrowed space between the lunate and triquetral bone with cysts and sclerosis similar to pseudoarthrosis. Magnetic resonance imaging showed bone marrow edema adjacent to the incomplete separated lunato-triquetral joint and Gd-DTPA enhancing fibrovascular tissue in the synovium and subarticular cysts, explaining the pain over the ulnar-sided wrist. Patients with congenital lunato-triquetral coalition may poorly tolerate stress loading or trauma, resulting in a symptomatic state similar to degenerative arthritis or pseudoarthrosis, which is demonstrated by enhanced MR imaging. (orig.) With 2 figs., 23 refs.

  12. Method of manufacturing fibrous hemostatic bandages

    Science.gov (United States)

    Larsen, Gustavo; Spretz, Ruben; Velarde-Ortiz, Raffet

    2012-09-04

    A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.

  13. Solitary Fibrous Tumor of the Cerebello-Pontine Angle

    Science.gov (United States)

    Biggs, Nigel D.; Fagan, Paul A.; Turner, Jennifer J.; Doust, Bruce

    1999-01-01

    A case is presented of solitary fibrous tumor occurring in the cerebello-pontine angle. There have been only two other reported cases of a solitary fibrous tumors in this region. Imaging studies showed the tumor to be characteristic in shape and position of an acoustic tumor. However, at surgery the tumor was found to have a “rock hard” consistency. Solitary fibrous tumor differs from acoustic schwannoma and meningioma in its histopathological features and in this case, regrowth, after incomplete excision, was extremely rapid. ImagesFigure 2Figure 3Figure 4Figure 5Figure 6 PMID:17171119

  14. Dielectric behavior characterization of functional fibrous-ceramic/polymer nanocomposites

    OpenAIRE

    Dağdeviren, Canan; Dagdeviren, Canan

    2009-01-01

    This study is mainly focused on forming fibrous-ceramic/polymer nanocomposites and characterizing their dielectric behavior. The fibrous-ZnO/PVDF nanocomposite is prepared in two steps. First, a network of nano-scale zinc oxide (ZnO) fibers is produced by sintering electrospun PVA/Zinc Acetate fibers. Second, the ZnO fibrous non-woven mat is sandwiched between two polyvinylidine fluoride (PVDF) thermoplastic polymer films by hot-press casting. Referring to the extensive literature search with...

  15. Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma.

    Science.gov (United States)

    Nair, Sreelakshmi N; Kini, Raghavendra; Rao, Prasanna Kumar; Bhandarkar, Gowri P; Kashyp, Roopashri Rajesh; Rai, Manjunath; Naik, Neel; Santhosh, Athul

    2016-01-01

    Fibrous dysplasia (FD) is a condition characterized by excessive proliferation of bone forming mesenchymal cells which can affect one bone (monostotic type) or multiple bones (polyostotic type). It is predominantly noticed in adolescents and young adults. Fibrous dysplasia affecting the jaws is an uncommon condition. The most commonly affected facial bone is the maxilla, with facial asymmetry being the chief complaint. The lesion in many instances is confused with ossifying fibroma (OF). Diagnosis of these two lesions has to be done based on clinical, radiographic, and microscopic findings. Here, we present a case of fibrous dysplasia of maxilla in a nine-year-old boy mimicking juvenile ossifying fibroma.

  16. Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma

    Science.gov (United States)

    Rao, Prasanna Kumar; Bhandarkar, Gowri P.; Rai, Manjunath; Naik, Neel; Santhosh, Athul

    2016-01-01

    Fibrous dysplasia (FD) is a condition characterized by excessive proliferation of bone forming mesenchymal cells which can affect one bone (monostotic type) or multiple bones (polyostotic type). It is predominantly noticed in adolescents and young adults. Fibrous dysplasia affecting the jaws is an uncommon condition. The most commonly affected facial bone is the maxilla, with facial asymmetry being the chief complaint. The lesion in many instances is confused with ossifying fibroma (OF). Diagnosis of these two lesions has to be done based on clinical, radiographic, and microscopic findings. Here, we present a case of fibrous dysplasia of maxilla in a nine-year-old boy mimicking juvenile ossifying fibroma. PMID:28101383

  17. Solitary fibrous tumor of the pleura.

    Science.gov (United States)

    Marak, Creticus P; Dorokhova, Olena; Guddati, Achuta K

    2013-01-01

    Solitary fibrous tumor of the pleura (SFTP) is a rare tumor of mesenchymal origin which can grow to a large size and present with symptoms of cough and pleuritic chest pain. No specific etiological factors for SFTPs are known and they may grow undetected for several years. These tumors are usually benign and may mimic a variety of malignancies. SFTPs are often detected as peripheral opacities on chest X-ray. Unfortunately, fine needle aspiration rarely provides adequate information for a definitive diagnosis. Imaging with computed tomography provides details about the size and extent of any invasion into adjacent tissues. Surgical resection is the mainstay of treatment, and immunohistochemistry of the resected tumor often provides confirmation of the diagnosis. Some SFTPs have been observed to be malignant, and surgical intervention is often lifesaving. There is no adequate data to support the usage of radiotherapy and chemotherapy in the treatment of SFTPs. This tumor exemplifies malignancies which require surgical resection to preempt worse outcomes. Awareness of their presentation and clinical course may help the clinician provide a prompt referral to the thoracic surgeon for resection.

  18. Treating Fibrous Insulation to Reduce Thermal Conductivity

    Science.gov (United States)

    Zinn, Alfred; Tarkanian, Ryan

    2009-01-01

    A chemical treatment reduces the convective and radiative contributions to the effective thermal conductivity of porous fibrous thermal-insulation tile. The net effect of the treatment is to coat the surfaces of fibers with a mixture of transition-metal oxides (TMOs) without filling the pores. The TMO coats reduce the cross-sectional areas available for convection while absorbing and scattering thermal radiation in the pores, thereby rendering the tile largely opaque to thermal radiation. The treatment involves a sol-gel process: A solution containing a mixture of transition-metal-oxide-precursor salts plus a gelling agent (e.g., tetraethylorthosilicate) is partially cured, then, before it visibly gels, is used to impregnate the tile. The solution in the tile is gelled, then dried, and then the tile is fired to convert the precursor salts to the desired mixed TMO phases. The amounts of the various TMOs ultimately incorporated into the tile can be tailored via the concentrations of salts in the solution, and the impregnation depth can be tailored via the viscosity of the solution and/or the volume of the solution relative to that of the tile. The amounts of the TMOs determine the absorption and scattering spectra.

  19. [Malignant fibrous histiocytoma of the penis].

    Science.gov (United States)

    Crisman, G; Margiotta, G; Calabresi, M; Discepoli, S; Leocata, P

    2015-07-01

    According to the most recent World Health Organization (WHO) guidelines a diagnosis of malignant fibrous histiocytoma (MFH) should be made only for lesions composed of tumor cells without evidence of a specific line of differentiation. This is therefore a diagnosis by exclusion which is why the name of undifferentiated high-grade pleomorphic sarcoma (UPS) should be preferred. Soft tissue sarcomas currently have an incidence in all body regions of approximately 20 cases per 1 million inhabitants per year. Soft tissue tumors of the penis represent approximately 5 % of all penile tumors and the incidence of penile sarcomas is estimated to be approximately 0.6-1 case per 100,000 patients. Only seven cases have so far been reported in the literature. This article describes the case of a 61-year-old Caucasian male who presented with a painless mass sited in the upper part of the corpus cavernosa. An incisional biopsy with a subsequent investigation using an extensive immunohistochemical panel were performed and a high-grade undifferentiated pleomorphic sarcoma or pleomorphic storiform MFH was diagnosed. In addition to the case report a literature review is presented to elaborate the discussion on the differential diagnoses of these kinds of lesions.

  20. Intracranial solitary fibrous tumor: Imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Clarencon, Frederic, E-mail: fredclare5@msn.com [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Bonneville, Fabrice [Department of Neuroradiology, Hopital Rangueil, Toulouse University Hospital, 31000 Toulouse (France); Rousseau, Audrey [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Galanaud, Damien [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Kujas, Michele [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Naggara, Olivier [Department of Neuroradiology, St Anne Hospital, 75014 Paris (France); Cornu, Philippe [Department of Neurosurgery, Pitie-Salpetriere Hospital (France); Chiras, Jacques [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France)

    2011-11-15

    Objective: To study the neuroimaging features of intracranial solitary fibrous tumors (ISFTs). Materials and methods: Retrospective study of neuroimaging features of 9 consecutive histopathologically proven ISFT cases. Location, size, shape, density, signal intensity and gadolinium uptake were studied at CT and MRI. Data collected from diffusion-weighted imaging (DWI) (3 patients), perfusion imaging and MR spectroscopy (2 patients), and DSA (4 patients) were also analyzed. Results: The tumors most frequently arose from the intracranial meninges (7/9), while the other lesions were intraventricular. Tumor size ranged from 2.5 to 10 cm (mean = 6.6 cm). They presented multilobular shape in 6/9 patients. Most ISFTs were heterogeneous (7/9) with areas of low T2 signal intensity that strongly enhanced after gadolinium administration (6/8). Erosion of the skull was present in about half of the cases (4/9). Components with decreased apparent diffusion coefficient were seen in 2/3 ISFTs on DWI. Spectroscopy revealed elevated peaks of choline and myo-inositol. MR perfusion showed features of hyperperfusion. Conclusion: ISFT should be considered in cases of extra-axial, supratentorial, heterogeneous, hypervascular tumor. Areas of low T2 signal intensity that strongly enhance after gadolinium injection are suggestive of this diagnosis. Restricted diffusion and elevated peak of myo-inositol may be additional valuable features.

  1. Reflective Coating on Fibrous Insulation for Reduced Heat Transfer

    Science.gov (United States)

    Hass, Derek D.; Prasad, B. Durga; Glass, David E.; Wiedemann, Karl E.

    1997-01-01

    Radiative heat transfer through fibrous insulation used in thermal protection systems (TPS) is significant at high temperatures (1200 C). Decreasing the radiative heat transfer through the fibrous insulation can thus have a major impact on the insulating ability of the TPS. Reflective coatings applied directly to the individual fibers in fibrous insulation should decrease the radiative heat transfer leading to an insulation with decreased effective thermal conductivity. Coatings with high infrared reflectance have been developed using sol-gel techniques. Using this technique, uniform coatings can be applied to fibrous insulation without an appreciable increase in insulation weight or density. Scanning electron microscopy, Fourier Transform infrared spectroscopy, and ellipsometry have been performed to evaluate coating performance.

  2. Fabrication of highly modulable fibrous 3D extracellular microenvironments

    KAUST Repository

    Zhang, Xixiang

    2017-06-13

    Three-dimensional (3D) in vitro scaffolds that mimic the irregular fibrous structures of in vivo extracellular matrix (ECM) are critical for many important biological applications. However, structural properties modulation of fibrous 3D scaffolds remains a challenge. Here, we report the first highly modulable 3D fibrous scaffolds self-assembled by high-aspect-ratio (HAR) microfibers. The scaffolds structural properties can be easily tailored to incorporate various physical cues, including geometry, stiffness, heterogeneity and nanotopography. Moreover, the fibrous scaffolds are readily and accurately patterned on desired locations of the substrate. Cell culture exhibits that our scaffolds can elicit strong bidirectional cell-material interactions. Furthermore, a functional disparity between the two-dimensional substrate and our 3D scaffolds is identified by cell spreading and proliferation data. These results prove the potential of the proposed scaffold as a biomimetic extracellular microenvironment for cell study.

  3. General Information about Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    Science.gov (United States)

    ... to the lung. Bone Metastasis or Bone with Lung Metastasis Osteosarcoma and malignant fibrous histiocytoma may spread to a distant bone and/or the lung. Treatment may include the following: Combination chemotherapy followed ...

  4. Treatment Option Overview (Osteosarcoma and Malignant Fibrous Histiocytoma of Bone)

    Science.gov (United States)

    ... to the lung. Bone Metastasis or Bone with Lung Metastasis Osteosarcoma and malignant fibrous histiocytoma may spread to a distant bone and/or the lung. Treatment may include the following: Combination chemotherapy followed ...

  5. MRI of fibrous cortical defect and non-ossifying fibroma

    Energy Technology Data Exchange (ETDEWEB)

    Mishima, Yoshiko; Aoki, Takatoshi; Watanabe, Hideyuki; Nakata, Hajime; Hashimoto, Hiroshi; Nakamura, Toshitaka [Univ. of Occupational and Environmental Health, Kitakyushu, Fukuoka (Japan). School of Medicine

    1999-02-01

    Fibrous cortical defect and non-ossifying fibroma are the benign fibrous lesions of bone commonly involving children. Their diagnosis is usually done with radiography, and MR examinations are rarely performed. We evaluated MRI findings of 11 lesions in 10 cases of fibrous cortical defect and non-ossifying fibroma. Signal intensity of the lesions was varied and large lesions (2 cm<) tended to show heterogeneous signal intensity on both T1-weighted and T2-weighted images corresponding to a mixture of components including fibrous tissue, hemosiderin and foam cells. MRI helps to delineate the extent of the involved bone and to assess the various histological components of the lesions. However, their diagnosis is basically made on the radiographic findings and the role of MRI is limited. (author)

  6. Ehlers-Danlos syndrome with monostotic fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Rao A

    1979-01-01

    Full Text Available An unusual case of Ehlers-Danlos syndrome with monostotic fibrous dysplasia of the humorus is presented. The other orthopae-dic manifestations, its complications and associated features are re-viewed and summarised.

  7. Fibrous epulis associated with impacted lower right third molar

    Directory of Open Access Journals (Sweden)

    Ni Putu Mira Sumarta

    2009-12-01

    Full Text Available Background: Epulis or epulides are lesions associated with gingival tissues. Fibrous epulis is a type of hyperplastic fibrous tissue mass located at the gingival which is slow growing, painless, having same color as the oral mucosa and firm on palpation. Anterior regions of the oral cavity are the frequently affected sites as these areas are more prone to be affected by calculus deposition and poor plaque control due to frequent teeth malposition. Removal of any irritating factors and excision of the lesion are the usual treatments. Purpose: This case report presents a rare case of fibrous epulis which occurred in the posterior region of the oral cavity and associated with impacted lower third molar. Case: A case of fibrous epulis at the lower right third molar area of three months duration is presented. The mass was slow growing, painless and on examination it was a pedunculated mass overlying the unerupted lower right third molar, having same color with the oral mucosa and firm on palpation. Clinically, the lesion was diagnosed as fibrous epulis associated with impacted lower right third molar. Case management: The treatment were surgical excision of the epulis and removal of the lower right third molar. The histopathology result showed tissue with squamous epithelial lining, achanthotic fibrous connective tissue, mononuclear inflammatory cells and few capillaries without signs of malignancy. This is consistent with the diagnosis of fibrous epulis. Conclusion: Fibrous epulis, although frequently occurred at the anterior region of the oral cavity, may rarely grow at the area of lower third molar. This phenomenon supports the theory that epulis can grow on any surface of oral mucous membrane as long as local irritants are present.

  8. Effects of compression on the sound absorption of fibrous

    DEFF Research Database (Denmark)

    Castagnede, Bernard; Akninen, Achour; Brouard, Achour

    2000-01-01

    During the compression of a fibrous mat, it is well known that the absorption properties are decreasing. In order to predict this change, some heuristic formulae are proposed which take into account the modifications of the physical parameters(porosity, resistivity, tortousity and shappe factors)......) which enter in the standard "equivalent fluid" model. Numerical predictions are then discussed and compared to experimental data obtained on a fibrous material(uncompressed and the compressed) used in automotive industry....

  9. Simulation and Analysis of Unbonded Nonwoven Fibrous Structures

    Directory of Open Access Journals (Sweden)

    Behnam Pourdeyhimi

    2006-11-01

    Full Text Available In this work we report on our algorithm for generating 3-D virtual structures resembling un-bonded fibrous webs. The paper discusses short and infinitely long fibers, each emulating a category of nonwoven fibrous medium. The structure Solid Volume Fraction (SVF, being the most important characteristic of a fibrous porous medium, is calculated for different fiberwebs and discussed in details. It is shown that the SVF of the fibrous structures generated by our algorithm is independent of the basis weight. In other words, the porosity of the medium is only a function of the fiber properties – this is as expected. It is also demonstrated that by decreasing the fiber diameter while keeping other properties of the virtual fiberweb constant causes the SVF to decrease almost linearly. The same is not observed for the fiber rigidity. The capability of our algorithm for generating fibrous webs made up of layers of different fibers is demonstrated and their properties are discussed. The application of such virtual fibrous structures in modeling transport phenomena in nonwoven materials and their potential applications in load-deformation studies are discussed.

  10. The usefulness of nucleomedical procedures in diagnosis of fibrous dysplasia

    Energy Technology Data Exchange (ETDEWEB)

    Otsuka, Nobuaki; Fukunaga, Masao; Ono, Shimato (Kawasaki Medical School, Kurashiki, Okayama (Japan)) (and others)

    1989-09-01

    Bone scintigraphy with {sup 99m}Tc-phosphorous compounds and {sup 67}Ga scintigraphy were performed in 8 patients (monostotic 3 cases, polyostotic 5 cases) with fibrous dysplasia. The tendency toward abnormal accumulation of radioactivity on bone scintigraphy was high in the tibia, maxilla, mandibule and ribs. The characteristics of the scintigraphic image at the sites of bone lesion in fibrous dysplasia were judged to be marked (++), moderate (+) or poor or minimal (-), according to the degree of accumulation of radioactivity. Eleven sites of fibrous dysplasia showed marked accumulation and 5 sites showed moderate accumulation. Poor or minimal accumulation was not observed in any fibrous dysplasia lesions. Sclerotic changes on bone roentgenograms appeared as marked accumulation of radionuclides on bone scintigraphy in all cases. Cystic changes on roentgenograms showed a tendency toward moderate accumulation on scintigrams. {sup 67}Ga scans were also all positive for 2 experimental cases (3 sites) of bone lesions of fibrous dysplasia. Thus, bone and {sup 67}Ga scintigraphies appear to be useful and essential in evaluating the pathophysiology of fibrous dysplasia. (author).

  11. Control and optimization of Clostridium tyrobutyricum ATCC 25755 adhesion into fibrous matrix in a fibrous bed bioreactor.

    Science.gov (United States)

    Jiang, Ling; Wang, Jufang; Liang, Shizhong; Cai, Jin; Xu, Zhinan

    2011-09-01

    The great performance of a fibrous bed bioreactor (FBB) is mainly dependent on the cell adhesion and immobilization into the fibrous matrix. Therefore, understanding the mechanism and factors controling cell adhesion in the fibrous matrix is necessary to optimize the FBB setup and further improve the fermentability. The adhesion behavior of a strain of Clostridium tyrobutyricum isolated from an FBB was studied, which was proven to be affected by the different environmental conditions, such as growth phase of cells, pH, ionic strength, ionic species, and composition of media. Our results also suggested that electrostatic interactions played an important role on bacteria adhesion into the fibrous matrix. This study demonstrated that the compositions of fermentation broth would have a significant effect on cell adhesion. Consequently, a two-stage glucose supply control strategy was developed to improve the performance of FBB with higher viable cell density in the operation of the FBB setup.

  12. Clinicopathological analysis of solitary fibrous tumor

    Institute of Scientific and Technical Information of China (English)

    Xiumei Zhang; Hai Wang; Shujing Wang; Jinfeng Miao; Zhengai Piao; Yingying Dong

    2012-01-01

    Objective: The aim of this study was to investigate the clinicopathologic characteristics, diagnosis and differential diagnosis, molecular genetics, treatment and prognosis of solitary fibrous tumor (SFT). Methods: The clinicopathological manifestations were analyzed retrospectively in 22 patients with surgically confirmed SFT. Results: There were 12 male patients and 10 female patients, with the age range 33–67 (mean 48.62) years. The SFTs originated from different from parts of the body, including 13 in the chest, 2 in the lungs, 3 in the abdomen, 1 in the lumbosacral area, 2 in the pelvis, and 1 in the left shoulder. There were 19 benign and 3 malignant tumors. Major clinical presentations were local masses and compression symptoms. Microscopy: the tumor was composed of areas of alternating hypercellularity and hypocellularity. The tumor cells were spindle to short-spindle shaped and arranged in fascicular or storiform pattern and hemangiopericytoma-like structure was presented. Immunohistochemically, Vimentin positive rate was 100% (22/22), Bcl-2 positive rate was 95.5% (21/22), CD99 positive rate was 86.4% (19/22), CD34 positive rate was 81.8 (18/22), focally positive for P53, as well as negative CK, S100 and Desmin. Ki67 labelling index was 2%–30%. Conclusion: SFT is a rare tumor which may be found in various parts of human body. SFT mostly is a benign tumor, but a few could be malignant. Its diagnosis mainly rely on its morphologic features and immunohistochemical profiles. The major treatment is to completely resect it by operation and long-term clinical follow-up is necessary.

  13. Gene expression profiling of solitary fibrous tumors.

    Directory of Open Access Journals (Sweden)

    François Bertucci

    Full Text Available BACKGROUND: Solitary fibrous tumors (SFTs are rare spindle-cell tumors. Their cell-of-origin and molecular basis are poorly known. They raise several clinical problems. Differential diagnosis may be difficult, prognosis is poorly apprehended by histoclinical features, and no effective therapy exists for advanced stages. METHODS: We profiled 16 SFT samples using whole-genome DNA microarrays and analyzed their expression profiles with publicly available profiles of 36 additional SFTs and 212 soft tissue sarcomas (STSs. Immunohistochemistry was applied to validate the expression of some discriminating genes. RESULTS: SFTs displayed whole-genome expression profiles more homogeneous and different from STSs, but closer to genetically-simple than genetically-complex STSs. The SFTs/STSs comparison identified a high percentage (∼30% of genes as differentially expressed, most of them without any DNA copy number alteration. One of the genes most overexpressed in SFTs encoded the ALDH1 stem cell marker. Several upregulated genes and associated ontologies were also related to progenitor/stem cells. SFTs also overexpressed genes encoding therapeutic targets such as kinases (EGFR, ERBB2, FGFR1, JAK2, histone deacetylases, or retinoic acid receptors. Their overexpression was found in all SFTs, regardless the anatomical location. Finally, we identified a 31-gene signature associated with the mitotic count, containing many genes related to cell cycle/mitosis, including AURKA. CONCLUSION: We established a robust repertoire of genes differentially expressed in SFTs. Certain overexpressed genes could provide new diagnostic (ALDH1A1, prognostic (AURKA and/or therapeutic targets.

  14. A call to expand regulation to all carcinogenic fibrous minerals

    Science.gov (United States)

    Baumann, F.; Steele, I.; Ambrosi, J.; Carbone, M.

    2013-05-01

    The regulatory term "asbestos" groups only the six fibrous minerals that were commercially used among approximately 400. The carcinogenicity of these six regulated minerals has been largely demonstrated and is related to fiber structure, fiber length/diameter ratio, and bio-persistence. From a public perception, the generic term "asbestos" refers to the fibrous minerals that cause asbestosis, mesothelioma and other cancers. However, other non-regulated fibrous minerals are potentially as dangerous as the regulatory asbestos because they share similar physical and chemical properties, epidemiological studies have demonstrated their relationship with asbestos-related diseases, and both in vitro and in vivo experiments have established the toxicity of these minerals. For example, the non-regulated asbestiform winchite and richterite minerals that contaminated the vermiculite mined from Libby, Montana, (USA) were associated with mesothelioma, lung cancer and asbestosis observed among the area's residents and miners. Many other examples of non-regulated carcinogenic fibrous minerals include, but are not limited to, antigorite, arfvedsonite, balangeroite, carlosturanite, erionite, fluoro-edenite, hornblende, mordenite, palygorskite, and sepiolite. To propose a regulatory definition that would provide protection from all carcinogenic fibers, we have conducted an interdisciplinary literature review to compare the characteristics of "asbestos" and of non-regulated mineral fibers that relate to carcinogenicity. We specifically studied two non-regulated fibrous minerals that are associated with asbestos-related diseases: the serpentine antigorite and the zeolite erionite. Both examples underscore the problem of regulation based on commercial, rather than scientific principles: 1) the occurrence of fibrous antigorite in materials used to pave roads has been correlated with high mesothelioma rates in New Caledonia. Antigorite was also the cause of asbestosis in Poland, and in

  15. Oxidative stress inhibition and oxidant activity by fibrous clays.

    Science.gov (United States)

    Cervini-Silva, Javiera; Nieto-Camacho, Antonio; Gómez-Vidales, Virginia

    2015-09-01

    Fibrous clays (sepiolite, palygorskite) are produced at 1.2m tonnes per year and have a wide range of industrial applications needing to replace long-fibre length asbestos. However, information on the beneficial effects of fibrous clays on health remains scarce. This paper reports on the effect of sepiolite (Vallecas, Spain) and palygorskite (Torrejón El Rubio, Spain) on cell damage via oxidative stress (determined as the progress of lipid peroxidation, LP). The extent of LP was assessed using the Thiobarbituric Acid Reactive Substances assay. The oxidant activity by fibrous clays was quantified using Electron-Paramagnetic Resonance. Sepiolite and palygorskite inhibited LP, whereby corresponding IC50 values were 6557±1024 and 4250±289μgmL(-1). As evidenced by dose-response experiments LP inhibition by palygorskite was surface-controlled. Fibrous clay surfaces did not stabilize HO species, except for suspensions containing 5000μgmL(-1). A strong oxidant (or weak anti-oxidant) activity favours the inhibition of LP by fibrous clays.

  16. Craniofacial fibrous dysplasia - A review of current management techniques

    Directory of Open Access Journals (Sweden)

    Yadavalli Guruprasad

    2012-01-01

    Full Text Available Fibrous dysplasia is a pathologic condition of bone of unknown etiology with no apparent familial, hereditary or congenital basis. Lichtenstein first coined the term in 1938 and in 1942 he and Jaffe separated it from other fibro-osseous lesions. It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton. Its management poses significant challenges to the surgeon. Craniofacial fibrous dysplasia is 1 of 3 types of fibrous dysplasia that can affect the bones of the craniofacial complex, including the mandible and maxilla. Fibrous dysplasia is a skeletal developmental disorder of the bone-forming mesenchyme that manifests as a defect in osteoblastic differentiation and maturation. It is a lesion of unknown etiology, uncertain pathogenesis, and diverse histopathology. Fibrous dysplasia represents about 2, 5% of all bone tumors and over 7% of all benign tumours. Over the years, we have gained a better understanding of its etiology, clinical behavior, and both surgical and non-surgical treatments.

  17. Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications

    Energy Technology Data Exchange (ETDEWEB)

    Padmaraj, O.; Rao, B. Nageswara; Jena, Paramananda; Satyanarayana, N., E-mail: nallanis2011@gmail.com [Department of Physics, Pondicherry University, Pondicherry-605014 (India); Venkateswarlu, M. [R and D, Amaraja batteries, Thirupathi-517501 (India)

    2014-04-24

    Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl{sub 2}O{sub 4})] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF{sub 6} in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl{sub 2}O{sub 4} exhibits high ionic conductivity of 2.80 × 10{sup −3} S/cm at room temperature. The charge-discharge capacity of Li/LiCoO{sub 2} coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl{sub 2}O{sub 4}] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator.

  18. Recurring fibrous dysplasia of anthro maxillary with cranial base invasion

    Directory of Open Access Journals (Sweden)

    Sousa, Kátia Maria Marabuco de

    2009-09-01

    Full Text Available Introduction: Fibrous dysplasia is an osseous lesion with an unknown etiology. It is characterized by the osseous maturation insufficiency. It may affect any bone, but the affection of craniofacial bones is the most critical for otorhinolaryngology. Maxilla is the most affected facial bone and the orbitary invasion is an uncommon event. The symptoms are unspecific and for its low suspicion and uncommonness, the diagnosis is generally late. The monostotic form presents a slow growth and asymptomatic course and needs to be followed up. The polyostotic type has a progressive behavior and is associated to recurrence and complications. Objective: To present two cases of patients with fibrous dysplasia diagnosis and describe the clinical presentation, radiological findings and the treatment of this pathology. Cases Report: Two cases of fibrous dysplasia are reported, which initially presented unspecific symptomatology, but with characteristic radiologic signs. They were submitted to surgical treatment for resection of the lesions and evolved with frequent recurrences with extensive affection of the facial sinuses, one patient had cranial base invasion and frontal craniotomy was needed for tumoral excision. Final Comments: Fibrous dysplasia is an uncommon osteopathy. The tomography is the choice method for characterization of the tumoral expansion, and helps in the surgical planning. The surgical strategy is indicated for symptomatic lesions, functions alterations or anatomic disorders. This article describes two uncommon manifestations of recurrent fibrous dysplasia with an extensive affection of anthro maxillary, ethmoidal and sphenoid sinuses, in addition to orbitary and cranial base invasion.

  19. [About a case of calcifying fibrous tumor of the pleura].

    Science.gov (United States)

    Rocas, Delphine; Thivolet-Béjui, Françoise; Tronc, François; Chalabreysse, Lara

    2015-12-01

    Calcifying fibrous tumor is a rare soft tissue benign tumor (OMS 2002). Some pleural localisations are described, which affect slightly older individuals than the other soft tissue forms. The calcifying fibrous tumor is included in the 2004 World Health Organization classification of pleural tumors. A pleural tumor located in the right inferior pulmonary lobe is diagnosed in a 59-year-old man. This pleural tumor is macroscopically well-circumscribed. Histologically, the rare spindle tumoral cells are located between bundles of a collagenous tissue, sometimes hyalinized, with psammomatous or dystrophic calcifications. The tumoral cells have a fibrohistiocytic origin. They stain positively for antibodies against vimentin, factor XIIIa, CD68, CD163, CD34. Antibodies against smooth muscle actin, desmin, PS100, ALK1 and EBV are negative. Main differencial diagnoses are other benign pleural tumors (solitary fibrous tumor, inflammatory myofibroblastique tumor), some malignant tumors (desmoplastic malignant pleural mesothelioma) and pleural pseudotumors (calcified pleural plaques, chronic fibrous pleuritis, amylose, hyalinizing granuloma). Our case is the 15th pleural calcifying fibrous tumor being reported. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. Computed tomographic features of fibrous dysplasia of maxillofacial region

    Energy Technology Data Exchange (ETDEWEB)

    Sontakke, Subodh Arun; Karjodka, Freny R [Nair Hospital Dental College, Mumba (India); Umarji, Hemant R [Government Dental College and Hospital, Mumbai (India)

    2011-03-15

    This study was to find the computed tomographic features of fibrous dysplasia of the maxillofacial region. All eight cases included in the study reported either to Government Dental College and Hospital or Nair Hospital Dental College, Mumbai between 2003 and 2009. The patients were prescribed computed tomogram in addition to conventional radiographs of maxillofacial region which were studied for characteristic features of fibrous dysplasia. The diagnosis of fibrous dysplasia was confirmed by histopathological report. All cases showed the ill-defined margins of lesions except in the region where the lesions were extending to cortex of the involved bone. Internal structure of all cases showed ground glass appearance. Four cases of maxillary lesion showed the displacement of maxillary sinus maintaining the shape of maxillary sinus. Two cases showed complete obliteration of maxillary sinus. Displacement of inferior alveolar canal did not follow any typical pattern in any of the cases but was displaced in different directions. The craniofacial type of fibrous dysplasia is as common as fibrous dysplasia of jaw. The margins, extent, internal structure and effect on surrounding structure are well detected on computed tomographic images.

  1. Radiological analysis of polyostotic fibrous dysplasia in skeletal system

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Ma Rie; Kim, Jin Sik; Kim, Han Suk [National Medical Center, Seoul (Korea, Republic of); Park, Soo Soung [Chung Ang University College of Medicine, Seoul (Korea, Republic of)

    1984-12-15

    Over a period of recent 3 years, the 5 cases of polyostotic fibrous dysplasia were proven histologically at National Medical Center, and they were evaluated and analyzed radiologically and clinically. The results were as follows: 1. The age of 5 patients ranged from 12 to 21. 2. In general, clinical symptoms of these patients were pain of affected sites and swelling , fracture, walking disturbance of lower extremities. 3. The order of frequent site of polyostotic fibrous dysplasia was skull (4 cases), femur (3 cases), maxilla (2 case), humerus, tibia, rib, radius, metacarpal bone and phalanx. 4. The characteristic radiological findings of polyostotic fibrous dysplasia were multicystic lesions with ground glass appearance, osteosclerosis, cortical thinning and pathologic fracture and deformity of long bones. Particularly, in the extremities, multicystic radiolucencies, groud glass appearance, shepherd's crook and coxa vara deformities were noticed, and in the skull and maxilla, sclerotic changes were principally demonstrated.

  2. Polyostotic Fibrous Dysplasia of Cranio-Maxillofacial Area

    Energy Technology Data Exchange (ETDEWEB)

    Han, Jin Woo; Kwon, Hyuk Rok; Lee, Jin Ho; Park, In Woo [Dept. of Oral and Maxillofacial Radiology, College of Dentistry, Kangnung National University, Kangnung (Korea, Republic of)

    2000-06-15

    Fibrous dysplasia is believed to be a hamartomatous developmental lesion of unknown origin. This disease is divided into monostotic and polyostotic fibrous dysplasia. Polyostotic type can be divided into craniofacial type, Lichtenstein-Jaffe type, and McCune-Albright syndrome. In this case, a 31-year-old female presented spontaneous loss of right mandibular teeth before 5 years and has shown continuous expansion of right mandibular alveolus. Through the radiographic view, the coarse pattern of the mixed radiopaque-lucent lesion was seen on the right mandibular body, and there was diffuse pattern of the mixed radiopaque-lucent lesion with ill-defined margin in the left mandibular body. In the right calvarium, the lesion had cotton-wool appearance. Partial excision for contouring, multiple extraction, and alveoloplasty were accomplished under general anesthesia for supportive treatment. Finally we could conclude this case was polyostotic fibrous dysplasia of cranio-maxillofacial area based on the clinical, radiologic finding, and histopathologic examination.

  3. 4D fibrous materials: characterising the deployment of paper architectures

    Science.gov (United States)

    Mulakkal, Manu C.; Seddon, Annela M.; Whittell, George; Manners, Ian; Trask, Richard S.

    2016-09-01

    Deployment of folded paper architecture using a fluid medium as the morphing stimulus presents a simple and inexpensive methodology capable of self-actuation; where the underlying principles can be translated to develop smart fibrous materials capable of programmable actuations. In this study we characterise different paper architectures and their stimuli mechanisms for folded deployment; including the influence of porosity, moisture, surfactant concentration, temperature, and hornification. We observe that actuation time decreases with paper grammage; through the addition of surfactants, and when the temperature is increased at the fluid-vapour interface. There is a clear effect of hydration, water transport and the interaction of hydrogen bonds within the fibrous architecture which drives the deployment of the folded regions. The importance of fibre volume fraction and functional fillers in shape recovery was also observed, as well as the effect of a multilayer composite paper system. The design guidelines shown here will inform the development of synthetic fibrous actuators for repeated deployment.

  4. Malign Fibrous Histiocytoma of the Bladder: A Rare Case Report

    Directory of Open Access Journals (Sweden)

    Ižbrahim Bozkurt

    2014-06-01

    Full Text Available Malignant fibrous histocytoma is a mesenchimal tumor, which was described in 1964. It is the most common soft tissue sarcoma in patients over the age of 40 years. There were very few reports about malignant fibrous histocytoma in urinary tract especially in bladder with 30 patients. Patients usually present with gross hematuria. Because of its agressive characteristics; recurrences, progressions and metastasis are likely. Tumor grade, tumor size, amount of invasion and histological type are the risk factors for metastasis. Early radical cystectomy is the first treatment option because of poor prognosis of these tumors but usually can not be sufficient. Chemotherapy and radiotherapy are used to as an alternative treatment or adjuvant treatment with surgery. We would like to present a bladder malignant fibrous histocytoma case to contribute to the lirature.

  5. Malignant fibrous histiocytoma of colon: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Hwan; Jee, Keum Nahn [Dankook University College of Medicine, Cheonan (Korea, Republic of)

    2006-03-15

    Gastrointestinal malignant fibrous histiocytomas (MFH) are very rare and only about 30 cases have been reported in the English literature, among which 20 cases were from colorectal MFHs. A small bowel MFH with intussusception has been the only reported case in the Korean medical literature. A 52-year-old male presented with complaints of recently developed and aggravated right upper abdominal pain. We present the CT appearance and the clinico-pathologic findings of his primary inflammatory malignant fibrous histiocytoma, which arose from the subserosal layer of the ascending colon with tumor infiltration in all the layers. The colon showed extensive hemorrhagic necrosis and repetitive multifocal microperforations with resultant panperitonitis.

  6. Focal electroencephalography rhythm asymmetry due to focal skull fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Michael A. Meyer

    2014-06-01

    Full Text Available An unusual pervasive and persistent asymmetry in background rhythm was found on surface electroencephalography (EEG recordings in a 22 year old with new onset of generalized seizure activity. Radiographic correlation with computed tomography, positron emission tomography and bone scan imaging uncovered that the higher amplitude left frontal-parietal background activity was related to a circumscribed area of left frontal-parietal fibrous dysplasia affecting the skull. This case report emphasizes that the presumed higher electrical conductance of fibrous dysplasia lead to a greater transparency of normal background rhythms, and must be taken into account as a form of breach rhythm for accurate EEG interpretation.

  7. Fibrous dysplasia localized to spine: a diagnostic dilemma

    Energy Technology Data Exchange (ETDEWEB)

    Gogia, Nidhi; Gulati, Manpreet [All India Institute of Medical Sciences, Department of Radiology, New Delhi (India); Marwaha, V. [All India Institute of Medical Sciences, Department of Radiology, New Delhi (India); All India Institute of Medical Sciences, Department of Medicine, New Delhi (India); Atri, S. [All India Institute of Medical Sciences, Department of Pathology, New Delhi (India); Gupta, Rajiva [All India Institute of Medical Sciences Ansari Nagar, Department of Medicine, Division of Rheumatology and Clinical Immunology, New Delhi (India)

    2007-06-15

    Fibrous dysplasia of the spine is uncommon, especially in monostotic form. Isolated vertebral involvement in polyostotic form is very rare. We report a case of polyostotic fibrous dysplasia with lesions localized to dorso-lumbar spine in a 45-year-old rheumatoid arthritis patient. No associated appendicular lesions, cutaneous manifestations or endocrinopathies were seen. The extreme rarity of this type of lesion can pose a diagnostic dilemma, and biopsy is required for diagnosis. The association with rheumatoid arthritis in our case seems to be a chance occurrence. (orig.)

  8. Non-steady-state aerosol filtration in nanostructured fibrous media.

    Science.gov (United States)

    Przekop, Rafal; Gradoń, Leon

    2011-06-28

    The filtration of aerosol particles using composites of nano- and microsized fibrous structures is a promising method for the effective separation of nanoparticles from gases. A multi-scale physical system describing the flow pattern and particle deposition at a non-steady-state condition requires an advanced method of modelling. The combination of lattice Boltzmann and Brownian dynamics was used for analysis of the particle deposition pattern in a fibrous system. The dendritic structures of deposits for neutral and charged fibres and particles are present. The efficiency of deposition, deposit morphology, porosity and fractal dimension were calculated for a selected operational condition of the process.

  9. Fibrous dysplasia of the jaws associated with secondary hyperparathyroidism: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Whi, Jung Hyun; Kim, Young Joo; Chun, Kyung Ah; Kim, Ki Tae; Chang, Eun Deok; Kim, Young Ok; Lee, Won [The Catholic University of Korea, Uijongbu (Korea, Republic of)

    2007-06-15

    There have been few reports on fibrous dyplasia associated with secondary hyperparathyroidism. We report a case of a hemodialysis patient with secondary hyperparathyroidism concomitant with fibrous dysplasia of the jaws causing an abnormal deformity.

  10. Filtration efficiency of an electrostatic fibrous filter: Studying filtration dependency on ultrafine particle exposure and composition

    DEFF Research Database (Denmark)

    Ardkapan, Siamak Rahimi; Johnson, Matthew S.; Yazdi, Sadegh

    2014-01-01

    The objective of the present study is to investigate the relationship between ultrafine particle concentrations and removal efficiencies for an electrostatic fibrous filter in a laboratory environment. Electrostatic fibrous filters capture particles efficiently, with a low pressure drop. Therefor...

  11. Malignant fibrous histiocytoma of the colon. Report of the case and review of the subject.

    Science.gov (United States)

    Baltaziak, M; Zimnoch, L; Sobaniec-Lotowska, M; Kemona, A; Dziecioł, J

    1993-01-01

    Primary and metastatic malignant fibrous histiocytoma of the alimentary tract is uncommon, even though it is the most frequently diagnosed malignant soft tissue tumor in adults. In this report, we describe a case of malignant fibrous histiocytoma of the colon.

  12. Localized fibrous tumor of the liver: imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Lecesne, R.; Drouillard, J.; Laurent, F. [Service d`Imagerie Medicale-Radiologie Diagnostique et Therapeutique, Hopital du Haut-Leveque, CHU Bordeaux, Pessac (France); Le Bail, B. [Department d`Anatomie et Cytologie Pathologiques, Groupe Hospitalier Pellegrin, CHU Bordeaux, Place Amelie Raba-Leon, Bordeaux (France); Saric, J. [Service de Chirurgie Digestive, Groupe Saint-Andre, CHU Bordeaux (France); Balabaud, C. [Service des Maladies de L`Appareil Digestif, Groupe Saint-Andre, CHU Bordeaux (France)

    1998-02-01

    We report the imaging of a localized fibrous tumor of the liver, focusing on color Doppler US, CT, MR imaging, and angiographic findings. We discuss the differential diagnosis of such a rare, benign lesion of the liver. Detailed imaging of this tumor has not been reported in the literature previously. (orig.) With 6 figs., 10 refs.

  13. Use of Zoledronic Acid in Paediatric Craniofacial Fibrous Dysplasia

    Directory of Open Access Journals (Sweden)

    Chiara Di Pede

    2016-01-01

    Full Text Available We describe a case of a paediatric patient affected by mandibular fibrous dysplasia (FD with severe and chronic pain who was successfully treated with zoledronic acid (ZOL: a third-generation bisphosphonate. Further research is needed to assess its safety and efficacy as a treatment option for FD in the paediatric population.

  14. Electrospinning of caseinates to create protective fibrous mats

    Science.gov (United States)

    Electrospinning is a nonthermal process that produces fibers on the micron- or nano-scale from a polymer solution. If produced by electrospinning of biopolymer solutions, fibrous mats may be created for protecting foods and allowing for the preservation and controlled release of bioactives for healt...

  15. Imitation model of destruction of aviation fibrous polymeric composite materials

    Directory of Open Access Journals (Sweden)

    В. М. Синеглазов

    2000-12-01

    Full Text Available Considered are models imitating influence of lighting on dielectric construction materials with elements of lighting protection. Described are models of current spreading in multilayer materials and thermal destruction of fibrous polymeric composite materials caused by lighting current flowing on such materials

  16. Transarterial Onyx Embolization of an Orbital Solitary Fibrous Tumor

    Science.gov (United States)

    Hashemi, Nafiseh; Ling, Jeanie D.; Soparkar, Charles; Sami, Mirwat; Ellezam, Benjamin; Klucznik, Richard; Lee, Andrew G.; Chévez-Barrios, Patricia

    2015-01-01

    Solitary fibrous tumor (SFT) is an uncommon mesenchymal neoplasm sometimes found in the orbit. We report a case of an aggressive orbital SFT with enlarged feeding vessels that was successfully resected immediately after transarterial embolization with Onyx (ethylene vinyl alcohol copolymer). To our knowledge, this is the first report showing the histopathology of Onyx embolization material in an orbital SFT. PMID:27171911

  17. Compressibility of CNT-Grafted Fibrous Reinforcements: A Theory

    NARCIS (Netherlands)

    Lomov, S.V.; Koissin, V.; Karahan, M.; Godara, A.; Gorbatikh, L.; Verpoest, I.

    2010-01-01

    The paper introduces a theoretical model of compressibility of a nanotube forest with randomly oriented nanotubes, which is applied to predict compressibility of a fibrous reinforcement with CNT-grafted fibres. It is shown that the pressure needed to achieve the target fibre volume fraction of the p

  18. [Poliostotic fibrous dysplasia with affectation of cervical rachis].

    Science.gov (United States)

    Lumbreras, Ruth; Aznar, Jose María; Castro, Angel; Modrego, Francisco Javier; Ballester, Juan José; Espallargas, Teresa

    2007-01-01

    The fibrous dysplasia is a benign although progressive dysfunction, in which a gene mutation originates the production of fibrous disorganized bony matrix. The bony tissue is replaced by bony tissue in expansion (amorph conjuntival tissue) that produces bony deformities in some patients, pain, pathological fractures or deambulation disorders. The diagnosis is important since ocasionally the first symptom is the fracture. We show up the case of a 21 year-old patient with pain clinic in high cervical region. The complementary tests (radiology, bone scintigrraphy and MRI) and anatomo-pathology confirmed the diagnosis of polyostotic fibrous dysplasia with cranial (occipital, esfenoides and right frontal and temporal bone), iliac, femoral, tibial and cervical (apophysis of C2) affectation. Our attitude was of carrying out a narrow observation by means of periodical strict controls, advising to avoid hard activities or contact sports. To the five years the patient is free of symptomatology. Radiologically the injuries have been stabilized. The fibrous dysplasia can affect to a single bone (monostotic) or to several (polyostotic). In occasions it is associated to endocrine dysfunctions and skin pigmentations in McCune-Albright's syndrome. We confront a pathology that specifies an anatomo-pathologic diagnosis to be confirmed, an extension diagnosis to detect asymptomatic focuses and whose treatment is symptomatic in most of the cases only using surgery in frank deformities or when the fracture risk is considerable, although the recurrence is frequent. The malignization is exceptional but possible that's why continuous observation is needed. The radiation therapy is radically contraindicated.

  19. Solitary fibrous tumor of the thyroid with capsular invasion.

    Science.gov (United States)

    Bohórquez, Concepción Lara; González-Cámpora, Ricardo; Loscertales, Miguel Congregado; Escudero, Antonio García; Mezquita, Jesús Congregado

    2003-01-01

    This report describes the clinical and pathologic findings of a peculiar case of solitary fibrous tumor of the thyroid gland that showed capsular invasion. After four and a half years of follow-up, neither local recurrence nor metastasis has developed.

  20. Compressibility of CNT-Grafted Fibrous Reinforcements: A Theory

    NARCIS (Netherlands)

    Lomov, S.V.; Koysin, V.; Karahan, M.; Godara, A.; Gorbatikh, L.; Verpoest, I.

    2010-01-01

    The paper introduces a theoretical model of compressibility of a nanotube forest with randomly oriented nanotubes, which is applied to predict compressibility of a fibrous reinforcement with CNT-grafted fibres. It is shown that the pressure needed to achieve the target fibre volume fraction of the

  1. Direct Numerical Simulation of Liquid Transport Through Fibrous Porous Media

    Science.gov (United States)

    Palakurthi, Nikhil Kumar

    Fluid flow through fibrous media occurs in many industrial processes, including, but not limited, to fuel cell technology, drug delivery patches, sanitary products, textile reinforcement, filtration, heat exchangers, and performance fabrics. Understanding the physical processes involved in fluid flow through fibrous media is essential for their characterization as well as for the optimization and development of new products. Macroscopic porous-media equations require constitutive relations, which account for the physical processes occurring at the micro-scale, to predict liquid transport at the macro-scale. In this study, micro-scale simulations were conducted using conventional computational fluid dynamics (CFD) technique (finite-volume method) to determine the macroscopic constitutive relations. The first part of this thesis deals with the single-phase flow in fibrous media, following which multi-phase flow through fibrous media was studied. Darcy permeability is an important parameter that characterizes creeping flow through a fibrous porous medium. It has a complex dependence on the medium's properties such as fibers' in-plane and through-plane orientation, diameter, aspect ratio, curvature, and porosity. A suite of 3D virtual fibrous structures with a wide range of geometric properties were constructed, and the permeability values of the structures were calculated by solving the 3D incompressible Navier-Stokes equations. The through-plane permeability was found to be a function of only the fiber diameter, the fibers' through-plane orientation, and the porosity of the medium. The numerical results were used to extend a permeability-porosity relation, developed in literature for 3D isotropic fibrous media, to a wide range of fibers' through-plane orientations. In applications where rate of capillary penetration is important, characterization of porous media usually involves determination of either the effective pore radius from capillary penetration experiments

  2. Restrictive lung disease and cor pulmonale secondary to polyostotic fibrous dysplasia.

    Science.gov (United States)

    Narayan, Rajeev L; Maldjian, Pierre D

    2009-01-09

    Polyostotic fibrous dysplasia is a rare benign pathological condition of bone in which proliferation of fibrous and osteoid elements results in expansile deformities of the skeleton. We present a case of polyostotic fibrous dysplasia in a young man in whom the severe deformities of the chest wall and spine produced restrictive lung disease, cor pulmonale and respiratory failure.

  3. Fibrous dysplasia of bone: craniofacial and dental implications.

    Science.gov (United States)

    Burke, A B; Collins, M T; Boyce, A M

    2016-08-05

    Fibrous dysplasia (FD) is a rare bone disease caused by postzygotic somatic activating mutations in the GNAS gene, which lead to constitutive activation of adenylyl cyclase and elevated levels of cyclic AMP, which act on downstream signaling pathways and cause normal bone to be replaced with fibrous tissue and abnormal (woven) bone. The bone disease may occur in one bone (monostotic), multiple bones (polyostotic), or in combination with hyperfunctioning endocrinopathies and hyperpigmented skin lesions (in the setting of McCune-Albright Syndrome). FD is common in the craniofacial skeleton, causing significant dysmorphic features, bone pain, and dental anomalies. This review summarizes the pathophysiology, clinical findings, and treatment of FD, with an emphasis on the craniofacial and oral manifestations of the disease.

  4. 3D CHARACTERIZATION OF WOOD BASED FIBROUS MATERIALS: AN APPLICATION

    Directory of Open Access Journals (Sweden)

    Jérôme Lux

    2011-05-01

    Full Text Available Morphological characterization of wood based fibrous materials is carried out using X-ray tomography. This technique allows the non destructive observation at the scales of a fibre (microscopic scale and of a network of fibres (mesoscopic scale. The 3D images are processed using classical tools of mathematical morphology. Measures of porosities and estimations of the size distributions of fibres and pores are carried out and compared to other results. An alternative method for the calculation of the local orientation of the fibres is also described to quantify the anisotropy of the fibres network. Finally, the individualization of the fibres is obtained from the representation of the fibrous network as a 3D skeleton, making possible further measurements on the isolated fibres.

  5. Retroperitoneal calcifying fibrous tumor mimicking an adrenal tumor.

    Science.gov (United States)

    Prochaska, Erica C; Sciallis, Andrew P; Miller, Barbra S

    2016-06-01

    Establishing the etiology of a retroperitoneal tumor may be difficult due to close proximity of multiple organs. Evaluation of retroperitoneal tumors often leads to surgery, many times to obtain a definitive diagnosis and rule out malignancy. Calcifying fibrous tumors (CFT) are very rare soft tissue tumors occurring most often in young patients. They are most often found arising in the thoracic cavity, mediastinum, abdominal cavity and extremities and usually have a benign clinical course. Macrocscopically, the tumors are well circumscribed and firm with a white-tan appearance. Histologically, CFT comprised a hypocellular proliferation of bland spindle cells, densely hyalinized collagen, chronic lymphoplasmacytic inflammation and dystrophic calcifications. Other considerations in the pathologic differential diagnosis include solitary fibrous tumor and inflammatory myofibroblastic tumor.

  6. The aerosol penetration through an electret fibrous filter

    Institute of Scientific and Technical Information of China (English)

    Jiang Wei; Cheung Chun-Shun; Chan Cheong-Ki; Zhu Chao

    2006-01-01

    The aim of this paper is to present a theoretical study of the aerosol penetration through an electret fibrous filter, using a numerical approach. The aerosol sizes considered in this study were in the submicron range, and in the numerical model, the conventional mechanical mechanisms (impaction, interception, diffusion and gravitationally settling) were taken into consideration along with the electrostatic mechanisms, including the Coulombic and dielectrophoretic effects. The aerosol penetration through an electret fibrous filter is heavily dependent on the aerosol penetration of a single fibre. The aerosol penetration through a single electret fibre under various filtration conditions was calculated. The effects of aerosol diameter, aerosol and fibre charge state, face velocity, packing density and aerosol dielectric constant on the aerosol penetration were investigated.

  7. Clinical guidelines for the management of craniofacial fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Lee JS

    2012-05-01

    Full Text Available Abstract Fibrous dysplasia (FD is a non-malignant condition caused by post-zygotic, activating mutations of the GNAS gene that results in inhibition of the differentiation and proliferation of bone-forming stromal cells and leads to the replacement of normal bone and marrow by fibrous tissue and woven bone. The phenotype is variable and may be isolated to a single skeletal site or multiple sites and sometimes is associated with extraskeletal manifestations in the skin and/or endocrine organs (McCune-Albright syndrome. The clinical behavior and progression of FD may also vary, thereby making the management of this condition difficult with few established clinical guidelines. This paper provides a clinically-focused comprehensive description of craniofacial FD, its natural progression, the components of the diagnostic evaluation and the multi-disciplinary management, and considerations for future research.

  8. Development of flame resistant treatment for Nomex fibrous structures

    Science.gov (United States)

    Toy, M. S.

    1977-01-01

    Flame resistant fibrous materials for space shuttle application were developed through chemical modification of commercially available aromatic polyamide fibrous products. The new surface treatment was achieved in the laboratory by ultraviolet activation of the fabric in the presence of fluoroolefin monomers and a diluent gas. The monomers grafted under these conditions provide the improved properties of the fabric in flame resistance, chemical inertness, and nonwettability without the sacrifice of color or physical properties. The laboratory reaction vessel was scaled-up to a batch continuous process, which treats ten yards of the commercial width textiles. The treated commercial width Nomex (HT-10-41) from the scaled-up reactor is self-extinguishing in an oxygen-enriched environment, water-repellent, soft, silky, and improved in chemical resistance. Unlike most textile processes, the grafting unit operates under dry conditions and no chemical by-products have to be washed out of the finished product.

  9. Aging-caused changes in optical anisotropy of fibrous tissues

    Science.gov (United States)

    Mikhailova, Alyona D.; Ermolenko, Sergey B.; Zimnyakov, Dmitry A.; Angelsky, Oleg V.

    2009-10-01

    Energy density approach as a modification of the coherent potential approximation was applied to analyze the influence of aging-caused changes in the fibrous tissue on its birefringence. The real fibrous tissue such as tendon was modeled by disordered array of partially oriented dielectric cylinders illuminated by a normally incident linearly polarized plane wave. The supraspinatus human tendon was taken as an object for theoretical modeling. The morphological features of the studied tissue were considered for a system of collagen fiber bundles embedded in a carbohydrate matrix. The latter one is a mixture of glycosaminoglycans and proteoglycans. Age-caused changes of the fibers and matrix influence on the spectral dependence of optical anisotropy spectrum.

  10. Fibrous dysplasia as a rare cause of nasolacrimal duct obstruction

    Directory of Open Access Journals (Sweden)

    Bahtiyar Polat

    2015-09-01

    Full Text Available Fibrous dysplasia of the paranasal sinuses is mostly asymptomatic, but sometimes may cause signs and symptoms de- pending on its location. We report two cases of maxillary fibrous dysplasia obstructing the lacrimal drainage system as a reason of chronic dacryocystitis, and reviewed the related literature. The first case underwent an endonasal endoscopic approach combined with external dacryocystorhinostomy. He had a patent lacrimal system at one-year follow-up. The le- sion was completely removed via an endonasal endoscopic approach in the second case, wherein the patient was asymp- tomatic of the six-month follow-up period. [Arch Clin Exp Surg 2015; 4(3.000: 172-175

  11. [Solitary fibrous tumor of endometrium--a case report].

    Science.gov (United States)

    Dvořák, O; Dvořáková, E; Laco, J; Spaček, J

    2013-06-01

    Solitary fibrous tumor (SFT) is an uncommon mesenchymal tumor. We present a case of SFT occurring in endometrium. Case report. Department of Obstetrics and Gynecology, The Fingerland Department of Pathology, Medical Faculty of Charles University and Faculty Hospital Hradec Králové. We report a case of 57 years old woman with SFT arising from the endometrium, which was diagnosed and treated at our department. Histological finding was supported by typical immunohistochemical profile of the tumor. Aggressive nature of the tumor wasnt showed. The patient underwent abdominal hysterectomy with bilateral adnexectomy and is followed up in regular periods. Occurence of solitary fibrous tumor (SFT) in the female genital tract is extremely rare. To the best of our knowledge, we report the first case of SFT occurring in endometrium. Because of potencial aggressive behaviour of the tumor complete surgical excision and close follow-up is highly recommended.

  12. [Fibrous pseudotumor of the vaginalis testis: report of a case].

    Science.gov (United States)

    Joual, A; Rabii, R; Guessous, H; Benjelloun, M; el Mrini, M; Benjelloun, S

    2000-06-01

    In this study, the authors have reported a case of a benign fibrous pseudotumor of the tunica vaginalis testis in a 24-year old man who was admitted with a left scrotal mass. Scrotal ultrasound and surgical investigation demonstrated the presence of a left testicular tumor; radical orchiectomy was performed by inguinal route. Microscopic examination revealed a pseudotumor of the testicular tunica vaginalis. As this is an uncommon lesion and preoperative diagnosis is difficult, unnecessary radical orchidectomy is often carried out.

  13. Focal fibrous overgrowths: A case series and review of literature

    OpenAIRE

    Kolte, Abhay P.; Rajshri A Kolte; Shrirao, Tushar S.

    2010-01-01

    Intraoral fibrous overgrowths of the soft tissues are relatively common and may be benign reactive or neoplastic lesions. A series of 10 lesions is presented which included pyogenic granuloma, fibroma and peripheral ossifying fibroma. Almost all the lesions occurred in the second and third decades and were present in the anterior segment of the jaws, with a distinct female predilection. Majority of these lesions were asymptomatic and the patients reported for treatment only due to the discomf...

  14. Solitary Fibrous Tumors and So-Called Hemangiopericytoma

    Directory of Open Access Journals (Sweden)

    Nicolas Penel

    2012-01-01

    Full Text Available We have reviewed the literature data regarding the spectrum of tumors including solitary fibrous tumor and hemangiopericytoma with special focus on definition of the disease, discussion of the criteria for malignancy, and the key elements of standard treatment of localized disease. We have discussed the emerging concepts on the tumor biology and the different systemic treatments (chemotherapy and molecular-targeted therapies.

  15. The ultrastructure of malignant fibrous histiocytoma (case report).

    Science.gov (United States)

    Lombardi, L; Pilotti, S; Carbone, A; Rilke, F

    1977-01-01

    A soft tissue malignant fibrous histiocytoma was studied by light and electron microscopy. The presence of fibroblast-like cells, histiocyte-like cells, undifferentiated stem cells, and xanthomatous cells was confirmed. Fibroblast- and histiocyte-like multinucleated giant cells were also observed. The observation of lysosomes in some fibroblast-like cells, the features of undifferentiated stem cells, and the presence of cells and intermediate characteristics common to xanthomatous, histiocytic, and stem cells suggest a strict relationship among these cellular types.

  16. Affine kinematics in planar fibrous connective tissues: an experimental investigation.

    Science.gov (United States)

    Jayyosi, C; Affagard, J-S; Ducourthial, G; Bonod-Bidaud, C; Lynch, B; Bancelin, S; Ruggiero, F; Schanne-Klein, M-C; Allain, J-M; Bruyère-Garnier, K; Coret, M

    2017-03-29

    The affine transformation hypothesis is usually adopted in order to link the tissue scale with the fibers scale in structural constitutive models of fibrous tissues. Thanks to the recent advances in imaging techniques, such as multiphoton microscopy, the microstructural behavior and kinematics of fibrous tissues can now be monitored at different stretching within the same sample. Therefore, the validity of the affine hypothesis can be investigated. In this paper, the fiber reorientation predicted by the affine assumption is compared to experimental data obtained during mechanical tests on skin and liver capsule coupled with microstructural imaging using multiphoton microscopy. The values of local strains and the collagen fibers orientation measured at increasing loading levels are used to compute a theoretical estimation of the affine reorientation of collagen fibers. The experimentally measured reorientation of collagen fibers during loading could not be successfully reproduced with this simple affine model. It suggests that other phenomena occur in the stretching process of planar fibrous connective tissues, which should be included in structural constitutive modeling approaches.

  17. Fibrous tissues growth and remodeling: Evolutionary micro-mechanical theory

    Science.gov (United States)

    Lanir, Yoram

    2017-10-01

    Living fibrous tissues are composite materials having the unique ability to adapt their size, shape, structure and mechanical properties in response to external loading. This adaptation, termed growth and remodeling (G&R), occurs throughout life and is achieved via cell-induced turnover of tissue constituents where some are degraded and new ones are produced. Realistic mathematical modeling of G&R provides insight into the basic processes, allows for hypotheses testing, and constitutes an essential tool for establishing clinical thresholds of pathological remodeling and for the production of tissue substitutes aimed to achieve target structure and properties. In this study, a general 3D micro-mechanical multi-scale theory of G&R in fibrous tissue was developed which connects between the evolution of the tissue structure and properties, and the underlying mechano-biological turnover events of its constituents. This structural approach circumvents a fundamental obstacle in modeling growth mechanics since the growth motion is not bijective. The model was realized for a flat tissue under two biaxial external loadings using data-based parameter values. The predictions show close similarity to characteristics of remodeled adult tissue including its structure, anisotropic and non-linear mechanical properties, and the onset of in situ pre-strain and pre-stress. The results suggest that these important features of living fibrous tissues evolve as they grow.

  18. Erosive separation of organic coatings from fibrous substrates.

    Science.gov (United States)

    Weiss, M; Momber, A W

    2004-11-01

    The separation of organic coatings from fibrous substrates is a key problem in recycling processes. This problem applies to carpets, technical textiles and automotive interior components. This paper reports about results of laboratory studies involving the application of high-speed liquid jets to solve this problem. Results from high-speed video images are used to qualify the principal erosion process. It is shown that the coating material is first ground by the jet; the generated erosion debris is then pushed through the permeable fibrous fabric of the substrate. It is also found that threshold conditions exist for the coating grinding process and for the debris transportation. These threshold conditions depend on target composition and process parameters. A phenomenological separation model is introduced. The influence of key process parameters, namely jet velocity, exposure time, stand-off distance and impact angle, is also investigated. It is found that high-speed liquid jets are suitable tools for separating organic coatings completely and selectively from fibrous substrates. Recommendations on how to optimise the erosion process are derived from the results.

  19. Monostotic fibrous dysplasia of the metacarpal: a case report

    Directory of Open Access Journals (Sweden)

    Kátia Tôrres Batista

    Full Text Available ABSTRACT Fibrous dysplasia is a bone disease characterized by abnormal differentiation of fibrous tissue in the bones; it is often asymptomatic. It may affect one bone (monostotic or several bones (polyostotic. The monostotic form primarily affects the ribs, but hardly ever affects the hand. It is important to make the differential diagnosis with malignant bone tumors. This article describes the treatment and outcome of a rare case of a patient admitted with a history of tumor growth in the right hand, diagnosed as fibrous dysplasia of the right second metacarpal. Male patient, 14 years of age, admitted to the Sarah Hospital with lesion on the dorsum of the right hand without pain complaints, previous history of trauma, nor local signs of inflammation. Physical examination revealed swelling on the dorsum of the second metacarpal, painless, with unaltered mobility and sensitivity. Radiography, computed tomography, and magnetic resonance imaging indicated the involvement of the entire length of the second metacarpal: only the distal epiphysis was preserved, with areas of bone lysis. After biopsy confirmation, the patient underwent surgery, using a long cortical graft for reconstructing the metacarpal. During the follow-up period of five years there were no signs of recurrence, and proper digital growth and functionality of the operated hand were observed.

  20. Essential Oil Bioactive Fibrous Membranes Prepared via Coaxial Electrospinning.

    Science.gov (United States)

    Yao, Zhi-Cheng; Chen, Si-Cong; Ahmad, Zeeshan; Huang, Jie; Chang, Ming-Wei; Li, Jing-Song

    2017-06-01

    A novel antimicrobial composite material was prepared by encapsulating orange essential oil (OEO) in zein prolamine (ZP) via the coaxial electrospinning (ES) technique. By manipulating process parameters, the morphological features of ZP/OEO fibers were modulated. Fine fibers with diameters ranging from 0.7 to 2.3 μm were obtained by regulating ZP solution concentration and process parameters during the ES process. Optimal loading capacity (LC) and encapsulation efficiency (EE) of OEO in fibrous ZP mats were determined to be 22.28% and 53.68%, respectively, and were achieved using a 35 w/v% ZP ES solution. The encapsulation of OEO was found to be reliant on ZP solution concentration (the enveloping medium). SEM analysis indicates the surface morphology of ZP/OEO electrospun fibers is dependent on ZP solution loading volume, with lower ZP concentrations yielding defective fibrous structures (for example, beaded and spindled-string like morphologies). Furthermore, this loading volume also influences OEO LC, EE, mat water contact angle and oil retention. CCK-8 assay and cell morphology assessment (HEK293T cells) indicate no significant change with electrospun ZP and ZP/OEO fibrous membranes over an 8 h period. Antimicrobial activity assessment using Escherichia coli, suggests composite nonwovens possess sterilization properties; elucidating potential application in active food packaging, food preservation and therefore sustainability. © 2017 Institute of Food Technologists®.

  1. Feed Technology of Fibrous Sugarcane Residues for Ruminants

    Directory of Open Access Journals (Sweden)

    Kuswandi

    2007-06-01

    Full Text Available Abundant sugarcane residue during shortage of roughage in dry season gives an opportunity to raise ruminants around sugarcane industries. However, these products are not widely used by farmers due to an assumption that the usage is inefficient and that the feed utilization technology is not widely recognized. Sugarcane fibrous residues (tops, bagasse and pith may be a potential feed component if pre-treated to increase its digestion and consumption by the animal, and/or supplemented by other ingredients to balance nutrients in the rumen as well as those for production purpose. Digestibility can be increased by chemical treatments such as ammoniation and other alkaline treatments, whereas consumption can be increased by physical treatments such as grinding, hammermilling or pelleting. Nutrients that are missing in these fibrous residues can be provided by addition of urea, molasses and minerals for maintenance need, and bypass nutrients (carbohydrates, protein and fats that are digested in the small intestine and available for tissue or milk synthesis. There are three options for development of livestock agribusiness based on fibrous sugarcane residues; however, these require several technologies to optimize the utilization of these residues.

  2. Hypotrichosis with keratosis pilaris: electrophoretical study of hair fibrous proteins from a patient.

    Science.gov (United States)

    Dekio, S; Nagashima, T; Watanabe, Y; Jidoi, J

    1989-01-01

    S-carboxymethylated (SCM) fibrous proteins from the scalp hair of a patient with hypotrichosis with keratosis pilaris (HTKP) and from that of a normal individual were analyzed using two-dimensional electrophoresis. One SCM fibrous protein component was different electrophoretically in the HTKP patient. It is suggested that the brittleness of the HTKP hair might result from this alteration of the fibrous protein composition of the hair.

  3. Angiomatoid fibrous histiocytoma in a 25-year-old male

    Directory of Open Access Journals (Sweden)

    David Dingli

    2010-06-01

    Full Text Available Angiomatoid fibrous histiocytoma (AFH is a rare disease that is often misdiagnosed initially. Patients can present with a clinical picture concerning for other diseases, and pathologic review is not always revealing. Molecular diagnostics are increasingly being utilized to detect gene fusions characteristic for AFH. Surgery remains the mainstay of management, and can effectively control local recurrences and metastases. Herein we describe a case report of a 25-year-old gentleman whose presentation was concerning for lymphoma. Subsequently we review of the relevant literature.

  4. Solitary Fibrous Tumor in Bladder:A Case Report

    Institute of Scientific and Technical Information of China (English)

    王涛; 陈瑞宝; 乔建坤; 胡涛; 刘继红; 杨为民; 叶章群

    2010-01-01

    Solitary fibrous tumor(SFT) in bladder is extremely rare.In this study,we reported one case of bladder SFT and reviewed the only ten cases of the disease that had been reported so far.The patient suffered from residual urine sensation and urethral pain.Cystoscopy revealed a 7-cm protruding mass at the dome of the bladder,and bladder mucosa biopsy showed normal differentiation of the bladder mucosa with a small amount of inflammatory cells.Radical resection of the tumor was performed in this patient.Patholog...

  5. Benign fibrous histiocytoma: A rare case involving jaw bone

    Directory of Open Access Journals (Sweden)

    Hitesh Shoor

    2015-01-01

    Full Text Available Benign fibrous histiocytoma (BFH is a soft tissue neoplasm which occurs mostly on the skin of extremities. BFH rarely occurs in bone and may affect femur, tibia, and pelvic bone. Jaw bone involvement is very unusual with only 11 cases reported till date. This report describes a case of BFH occurring in a 30-year-old female patient affecting left mandibular posterior region. Computed tomography revealed a well-defined expansile lytic lesion in the posterior mandible. Gross examination of the tumor revealed an admixture of fibroblasts and histiocytes in a fascicular and storiform pattern. Immunohistochemical staining was positive for CD68.

  6. Benign fibrous histiocytoma: A rare case involving jaw bone.

    Science.gov (United States)

    Shoor, Hitesh; Pai, Keerthilatha M; Shergill, Ankur Kaur; Kamath, Abhay Taranath

    2015-09-01

    Benign fibrous histiocytoma (BFH) is a soft tissue neoplasm which occurs mostly on the skin of extremities. BFH rarely occurs in bone and may affect femur, tibia, and pelvic bone. Jaw bone involvement is very unusual with only 11 cases reported till date. This report describes a case of BFH occurring in a 30-year-old female patient affecting left mandibular posterior region. Computed tomography revealed a well-defined expansile lytic lesion in the posterior mandible. Gross examination of the tumor revealed an admixture of fibroblasts and histiocytes in a fascicular and storiform pattern. Immunohistochemical staining was positive for CD68.

  7. Metastatic melanoma mimicking solitary fibrous tumor: report of two cases.

    Science.gov (United States)

    Bekers, Elise M; van Engen-van Grunsven, Adriana C H; Groenen, Patricia J T A; Westdorp, Harm; Koornstra, Rutger H T; Bonenkamp, Johannes J; Flucke, Uta; Blokx, Willeke A M

    2014-02-01

    Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We present one case each of recurrent and metastatic melanoma, both showing histological and immunohistochemical features of solitary fibrous tumor (SFT). Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma.

  8. The Experiment of Drying Process of the Fibrous Material

    Directory of Open Access Journals (Sweden)

    Jiří RASZKA

    2015-06-01

    Full Text Available The article describes the experiment of water evaporation from fibrous material (cotton. The material is placed in the tube and hot air flows through (process of drying. Temperature of air is measured by thermocouple. The textile represents porous medium with certain amount of water (wet textile. Porous layer makes pressure drop when airflow starts. Properties of air (temperature, relative humidity change during evaporation process. Values of pressure drop, temperature and humidity measured during experiment are used for set up of boundary condition, porous layer and evaporation model in Ansys Fluent 13.

  9. Aerosol Filtration Application Using Fibrous Media An Industrial Perspective

    Institute of Scientific and Technical Information of China (English)

    杨传芳

    2012-01-01

    Filtration of aerosol particles using non-woven fibrous media is a common practice for air cleaning. It has found wide applications in industries and our daily lives. This paper overviews some of these applications and provides an industrial perspective. It starts from discussing aerosol filtration theory, followed by a brief review on the advancement of filtration media. After that, filtration applications in respiratory protection, dust collection, and engine in-take air cleaning are elaborated. These are the areas that the author sees as the typical needed ones in China's fast pace economical development endeavor, where air filtration enables the protection of human health, environment and equipment for sustainability.

  10. Fibrous harmatoma of infancy in the scrotum: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hee Kyung; Kim, Kyu Soon; Kang, Dong Wook; Lee, Seung Yeon [Eulji University Hospital, Daejeon (Korea, Republic of)

    2017-02-15

    Fibrous hamartoma of infancy (FHI) is a rare, benign subcutaneous tumor occurring mainly before the age of 2 years. The most commonly reported locations of FHI are the extremities such as the shoulder or axilla. However, FHI arising in the genital area is extremely rare and has not been reported with correlated radiologic findings. In this case report, we present a case of 5-month-old male child diagnosed with FHI in the scrotum, with a focus on the correlation between the radiologic and pathologic findings.

  11. Fibrous dysplasia of maxilla: Report of two cases

    Directory of Open Access Journals (Sweden)

    Nisha Dua

    2015-01-01

    Full Text Available Fibrous dysplasia (FD is an idiopathic skeletal disorder in which the trabecular bone is replaced and distorted by poorly organized, structurally unsound fibro-osseous tissue. The lesion is classified into two forms: Monostotic (75-80% and polyostotic. A distinct form of Polyostotic FD, known as McCune-Albright Syndrome, is accompanied by cutaneous pigmentation and sexual precocity, and this occurs almost exclusively in women. Typical radiographic appearance shows an expanded osseous lesion having poorly defined margins covered by a thin "eggshell" cortex and lacking periosteal new bone formation. Here, we are presenting two case reports of FD involving the maxilla.

  12. Craniofacial surgery and optic canal decompression in adult fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Mahapatra A

    2003-01-01

    Full Text Available A 29-year-old female had a 3-year history of bony swelling over the right frontal area. For 3 months she noticed proptosis of her right eye. Investigations revealed fibrous dysplasia involving the right half of the frontal bone and the right greater and lesser wings of the sphenoid bone. Visual evoked potentials (VEP showed delayed latencies on the involved side. A craniofacial surgery with optic canal decompression was performed. Follow-up after 2 years revealed normalization of VEP.

  13. Solitary fibrous tumor arising in an intrathoracic goiter

    DEFF Research Database (Denmark)

    Larsen, Stine Rosenkilde; Godballe, Christian; Krogdahl, Annelise

    2010-01-01

    . CONCLUSION: The histological appearance and immunohistochemical reaction pattern of SFT is characteristic. The entity should be considered when dealing with a spindle cell lesion in the thyroid gland. All cases of this site of origin reported have had a benign clinical course. As only a small number of cases......BACKGROUND: Solitary fibrous tumor (SFT) is a rare spindle cell tumor most often found in the mediastinal pleura. Nineteen cases of SFT arising in the thyroid gland have been reported. We report a case of SFT of the thyroid gland with immunohistochemical and cytogenetic investigation. SUMMARY: A 58...

  14. Solitary fibrous tumor of the orbit presenting in pregnancy

    Directory of Open Access Journals (Sweden)

    Das Jayanta

    2009-01-01

    Full Text Available A 32-year-old woman, three months pregnant, reported with the complaint of protrusion of the right eye for six months. She gave history of rapid protrusion of eyeball for the last two months along with the history of double vision for the last one month. Computer tomography (CT scan revealed a well-defined mass lesion in the intraconal space of the right orbit which was excised through a lateral orbitotomy approach. Histological examination and immunohistochemistry revealed a solitary fibrous tumor, which showed a rapid progression in pregnancy.

  15. Structure-induced nonlinear viscoelasticity of non-woven fibrous matrices.

    Science.gov (United States)

    Rizvi, Mohd Suhail; Pal, Anupam; Das, Sovan Lal

    2016-12-01

    Fibrous materials are widely utilized as tissue engineering scaffolds for tissue regeneration and other bioengineering applications. The structural as well as mechanical characteristics of the fibrous matrices under static and dynamic mechanical loading conditions influence the response of the cells. In this paper, we study the mechanical response of the non-woven fibrous matrices under oscillatory loading conditions and its dependence on the structural properties of fibrous matrix. We demonstrate that under oscillatory shear and elongation, the fibrous matrices demonstrate nonlinear viscoelasticity at all strain amplitudes. This is contrary to the behavior of other soft polymeric materials for which nonlinearity in the viscoelastic response vanishes for small strains. These observations suggest that despite their prevalence, the measures of linear viscoelasticity (e.g., storage and loss moduli) are inadequate for the general description of the viscoelastic nature of the fibrous materials. It was, however, found that linear viscoelastic nature of fibrous matrices for small amplitudes is restored when a pre-stretch is applied to the fibrous matrix along with oscillatory strains. Further, we also explored the influence of the structural properties of the fibrous matrices (fiber orientation, alignment and curvature) on their viscoelastic nature.

  16. Epidermal nevus syndrome associated with polyostotic fibrous dysplasia, CNS lipoma, and aplasia cutis

    National Research Council Canada - National Science Library

    Cabanillas, Miguel; Aneiros, Angel; Monteagudo, Benigno; Santos-García, Diego; Suárez-Amor, Oscar; Ramírez-Santos, Aquilina

    2009-01-01

    ... and urogenital systems. We describe a patient with an extensive epidermal nevus associated with various organ abnormalities, particularly polyostotic fibrous dysplasia, central nervous system lipoma, and aplasia cutis...

  17. Permeability and compression of fibrous porous media generated from dilute suspensions of fiberglass debris during a loss of coolant accident

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Saya, E-mail: sayalee@tamu.edu; Abdulsattar, Suhaeb S.; Vaghetto, Rodolfo; Hassan, Yassin A.

    2015-09-15

    Highlights: • Experimental investigation on fibrous debris buildup was conducted. • Head loss through fibrous media was recorded at different approach velocities. • A head loss model through fibrous media was proposed for high porosity (>0.99). • A compression model of fibrous media was developed. - Abstract: Permeability of fibrous porous media has been studied for decades in various engineering applications, including liquid purifications, air filters, and textiles. In nuclear engineering, fiberglass has been found to be a hazard during a Loss-of-Coolant Accident. The high energy steam jet from a break impinges on surrounding fiberglass insulation materials, producing a large amount of fibrous debris. The fibrous debris is then transported through the reactor containment and reaches the sump strainers. Accumulation of such debris on the surface of the strainers produces a fibrous bed, which is a fibrous porous medium that can undermine reactor core cooling. The present study investigated the buildup of fibrous porous media on two types of perforated plate and the pressure drop through the fibrous porous media without chemical effect. The development of the fibrous bed was visually recorded in order to correlate the pressure drop, the approach velocity, and the thickness of the fibrous porous media. The experimental results were compared to semi-theoretical models and theoretical models proposed by other researchers. Additionally, a compression model was developed to predict the thickness and the local porosity of a fibrous bed as a function of pressure.

  18. [Malignant fibrous histiocytoma of the chest wall in a nonagenarian].

    Science.gov (United States)

    Kodama, K; Igase, M; Kazatani, Y; Matsuzaki, K; Murakami, E; Kokubu, T

    1995-01-01

    We report a case of malignant fibrous histiocytoma of the chest wall observed in a 94-year-old woman. She noticed appetite loss and general edema a week before admission. The patient was diagnosed as having congestive heart failure due to valvular heart disease on the basis of echocardiographic findings and became symptom-free by treatment with vasodilators and diuretics. However, chest roentgenogram disclosed a extrapleural mass in the left mid-lateral chest. About 2 months after admission, she experienced left lateral chest pain for the first time. The chest CT scan revealed a 5 x 5 x 2 cm mass, adjacent to the lateral-posterior chest wall and projecting into the thoracic cavity and rib osteolysis. Gallium-67 citrate scintigram showed abnormal isotope accumulation in the left middle chest. Biopsy was not done. The therapeutic approach was mainly pain relief, and no tumor resection, chemotherapy, or radiotherapy was performed. The mass increased in size, and increasingly extended into the thoracic cavity on follow-up CT scans. Furthermore, marked invasion of the tumor to subcutis and subscapula was found. She died of cachexia and respiratory failure 34 weeks after admission. Histologic examination revealed malignant fibrous histiocytoma.

  19. Heat Transfer Modeling for Rigid High-Temperature Fibrous Insulation

    Science.gov (United States)

    Daryabeigi, Kamran; Cunnington, George R.; Knutson, Jeffrey R.

    2012-01-01

    Combined radiation and conduction heat transfer through a high-temperature, high-porosity, rigid multiple-fiber fibrous insulation was modeled using a thermal model previously used to model heat transfer in flexible single-fiber fibrous insulation. The rigid insulation studied was alumina enhanced thermal barrier (AETB) at densities between 130 and 260 kilograms per cubic meter. The model consists of using the diffusion approximation for radiation heat transfer, a semi-empirical solid conduction model, and a standard gas conduction model. The relevant parameters needed for the heat transfer model were estimated from steady-state thermal measurements in nitrogen gas at various temperatures and environmental pressures. The heat transfer modeling methodology was evaluated by comparison with standard thermal conductivity measurements, and steady-state thermal measurements in helium and carbon dioxide gases. The heat transfer model is applicable over the temperature range of 300 to 1360 K, pressure range of 0.133 to 101.3 x 10(exp 3) Pa, and over the insulation density range of 130 to 260 kilograms per cubic meter in various gaseous environments.

  20. Coupled continuum and molecular model of flow through fibrous filter

    Science.gov (United States)

    Zhao, Shunliu; Povitsky, Alex

    2013-11-01

    A coupled approach combining the continuum boundary singularity method (BSM) and the molecular direct simulation Monte Carlo (DSMC) is developed and validated using Taylor-Couette flow and the flow about a single fiber confined between two parallel walls. In the proposed approach, the DSMC is applied to an annular region enclosing the fiber and the BSM is employed in the entire flow domain. The parameters used in the DSMC and the coupling procedure, such as the number of simulated particles, the cell size, and the size of the coupling zone are determined by inspecting the accuracy of pressure drop obtained for the range of Knudsen numbers between zero and unity. The developed approach is used to study flowfield of fibrous filtration flows. It is observed that in the partial-slip flow regime, Kn ⩽ 0.25, the results obtained by the proposed coupled BSM-DSMC method match the solution by BSM combined with the heuristic partial-slip boundary conditions. For transition molecular-to-continuum Knudsen numbers, 0.25 pressure drop and velocity between these two approaches is significant. This difference increases with the Knudsen number that confirms the usefulness of coupled continuum and molecular methods in numerical modeling of transition low Reynolds number flows in fibrous filters.

  1. [Malignant fibrous histiocytoma: pleomorphic sarcoma NOS or pleomorphic fibrosarcoma].

    Science.gov (United States)

    Meister, P

    2005-03-01

    The entity and nosology of pleomorphic malignant fibrous histiocytoma (MFH) is still ambiguous. The actual WHO-Classification uses pleomorphic malignant fibrous histiocytoma (MFH) and pleomorphic sarcoma NOS (not otherwise specified) synonymously. On the other hand text and illustrations convey the impression, that these tumors also could be pleomorphic lipo-, leio- or rhabdomyosarcomas etc. It would have been more informative to emphasize, that with the above mentioned specific sarcoma types MFH-like appearance may occur. Furthermore it would have been more up to date to consider pleomorphic sarcomas NOS as pleomorphic fibrosarcomas and include them in the chapter of fibroblastic and myofibroblastic tumors. This concept already has been carried out for the former myxoid variant of MFH, nowadays preferentially called myxofibrosarcoma. There is controversial discussion about the clinical significance of exact typing of pleomorphic sarcomas. Problems may also occur due to the lack of standards, which degree of desmin expression signifies leiomyosarcoma or just indicates myofibroblasts in MFH. The requirement of exclusion of other tumor-types before diagnosing pleomorphic fibrosarcoma still remains obligatory. After verification of the diagnosis pleomorphic sarcoma NOS or pleomorphic fibrosarcoma, grading e.g. according to criteria of the FFCCS can be carried out. Most cases of pleomorphic fibrosarcoma will qualify as high grade malignant.

  2. Electrospun 3D Fibrous Scaffolds for Chronic Wound Repair

    Directory of Open Access Journals (Sweden)

    Huizhi Chen

    2016-04-01

    Full Text Available Chronic wounds are difficult to heal spontaneously largely due to the corrupted extracellular matrix (ECM where cell ingrowth is obstructed. Thus, the objective of this study was to develop a three-dimensional (3D biodegradable scaffold mimicking native ECM to replace the missing or dysfunctional ECM, which may be an essential strategy for wound healing. The 3D fibrous scaffolds of poly(lactic acid-co-glycolic acid (PLGA were successfully fabricated by liquid-collecting electrospinning, with 5~20 µm interconnected pores. Surface modification with the native ECM component aims at providing biological recognition for cell growth. Human dermal fibroblasts (HDFs successfully infiltrated into scaffolds at a depth of ~1400 µm after seven days of culturing, and showed significant progressive proliferation on scaffolds immobilized with collagen type I. In vivo models showed that chronic wounds treated with scaffolds had a faster healing rate. These results indicate that the 3D fibrous scaffolds may be a potential wound dressing for chronic wound repair.

  3. Electrostatic layer-by-layer construction of fibrous TMV biofilms.

    Science.gov (United States)

    Tiu, Brylee David B; Kernan, Daniel L; Tiu, Sicily B; Wen, Amy M; Zheng, Yi; Pokorski, Jonathan K; Advincula, Rigoberto C; Steinmetz, Nicole F

    2017-01-26

    As nature's choice in designing complex architectures, the bottom-up assembly of nanoscale building blocks offers unique solutions in achieving more complex and smaller morphologies with wide-ranging applications in medicine, energy, and materials science as compared to top-down manufacturing. In this work, we employ charged tobacco mosaic virus (TMV-wt and TMV-lys) nanoparticles in constructing multilayered fibrous networks via electrostatic layer-by-layer (LbL) deposition. In neutral aqueous media, TMV-wt assumes an anionic surface charge. TMV-wt was paired with a genetically engineered TMV-lys variant that displays a corona of lysine side chains on its solvent-exposed surface. The electrostatic interaction between TMV-wt and TMV-lys nanoparticles became the driving force in the highly controlled buildup of the multilayer TMV constructs. Since the resulting morphology closely resembles the 3-dimensional fibrous network of an extracellular matrix (ECM), the capability of the TMV assemblies to support the adhesion of NIH-3T3 fibroblast cells was investigated, demonstrating potential utility in regenerative medicine. Lastly, the layer-by-layer deposition was extended to release the TMV scaffolds as free-standing biomembranes. To demonstrate potential application in drug delivery or vaccine technology, cargo-functionalized TMV biofilms were programmed.

  4. Fibrous Fillers to Manufacture Ultra High Ash/Performance Paper

    Energy Technology Data Exchange (ETDEWEB)

    Dr. VIjay K. Mathur

    2009-04-30

    The paper industry is one of the largest users of energy and emitters of CO2 in the US manufacturing industry. In addition to that, it is facing tremendous financial pressure due to lower cost imports. The fine paper industry has shrunk from 15 million tons per year production to 10 million tons per year in the last 5 years. This has resulted in mill closures and job loses. The AF&PA and the DOE formed a program called Agenda 2020 to help in funding to develop breakthrough technologies to provide help in meeting these challenges. The objectives of this project were to optimize and scale-up Fibrous Fillers technology, ready for commercial deployment and to develop ultra high ash/high performance paper using Fibrous Fillers. The goal was to reduce energy consumption, carbon footprint, and cost of manufacturing paper and related industries. GRI International (GRI) has been able to demonstrate the techno - economic feasibility and economic advantages of using its various products in both handsheets as well as in commercial paper mills. GRI has also been able to develop sophisticated models that demonstrate the effect of combinations of GRI's fillers at multiple filler levels. GRI has also been able to develop, optimize, and successfully scale-up new products for use in commercial paper mills.

  5. High-surface-area silica nanospheres (KCC-1) with a fibrous morphology

    KAUST Repository

    Polshettiwar, Vivek

    2010-08-02

    Fibrous nanosilica: A new family of high-surface-area silica nanospheres (KCC-1) have been prepared (see picture). KCC-1 features excellent physical properties, including high surface area, unprecedented fibrous surface morphology, high thermal (up to 950 °C) and hydrothermal stabilities, and high mechanical stability. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. INFILTRATION KINETICS MODEL OF LIQUID METAL INTO A FIBROUS PREFORM IN CENTRIFUGAL ACCELERATING FIELD

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The infiltration kinetics of the metal melt into a fibrous preform in centrifugal accelerating field is analyzed on the basis of Da rcy's law and the assumption that the fibrous preform is treated as “bundle of capillaries”. The critical rotating speed is analyzed with the established mo del. The influences of the metal melt mass,the rotating speed of the equipmen t,the casting height, the original outer radius of the metal melt and the fibrou s volume fraction in fibrous preform on infilatration are studied. The results show that the critical rotating speed is dependent on critical pressure, castin g height, metal melt mass and the character of fibrous preform. With the incr ease in the metal melt mass, rotating speed of the equipment and original outer radius of the metal melt, or the decrease in casting height and fibrous volume f raction in fibrous of the metal melt,or the decrease in casting height and fibro us volume fraction in fibrous preform,infiltration of metal melt for fibrous pre form becomes easier.

  7. Low level hydrogen peroxide generation from a nonwoven fibrous pectin-cellulose blend

    Science.gov (United States)

    Fibrous pectic-cellulose (FPC) (cellulose blended with primary cell wall pectin at 2 percent by weight of pectin) is product made from naturally occurring plant fibers. FPC is a fibrous mixture of polysaccharides with a low percent by weight of pectin-based primary cell wall and lipid components att...

  8. Evaluation of different measurements for effective thermal conductivity of fibrous materials

    Directory of Open Access Journals (Sweden)

    Tian Ming-Wei

    2014-01-01

    Full Text Available Effective thermal conductivity is generally recognized as the intrinsic factor to reveal the thermal responses of fibrous materials. Here, two typical measurements, the step-wise transient method and the guarded hot plate method, were utilized to identify their feasibility for the effective thermal conductivity of fibrous materials (non-woven fabric and twill fabric with different stacking layers.

  9. FIBROUS DYSPLASIA IN THE MAXILLO-MANDIBULAR REGION – case report

    Directory of Open Access Journals (Sweden)

    Radka Cholakova

    2010-07-01

    Full Text Available Craniofacial fibrous dysplasia is 1 of 3 types of fibrous dysplasia that can affect the bones of the craniofacial complex, including the mandible and maxilla.Fibrous displasia is a skeletal developmental disorder of the bone-forming mesenchyme that manifests as a defect in osteoblastic differentiation and maturation. It is a lesion of unknown etiology, uncertain pathogenesis, and diverse histopathology. Fibrous dysplasia represents about 2, 5% of all bone tumors and over 7% of all benign tumours.The aim of this article is to represent a rare case of bilateral fibrous dysplasia of the upper and lower jaws, in combination with Intellectual disability (previously called mental retardation. The clinical diagnostic approach including imaging studies: Orthopantomogram (OPG and 3D tomography is described. Histological examination was also essential for obtaining a definitive diagnosis.

  10. Fibrous scar in the infrapatellar fat pad after arthroscopy. MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Guangyu; Niitsu, Mamoru; Ikeda, Kotaro; Itai, Yuji [Tsukuba Univ., Ibaraki (Japan). Inst. of Clinical Medicine; Endo, Hideho

    2000-02-01

    We describe the MR appearance of fibrous scars in the infrapatellar fat pad after arthroscopy. The subjects were 96 patients who underwent arthroscope-assisted anterior cruciate ligament (ACL) reconstruction and were examined by oblique sagittal MR imaging at different follow-up intervals. Two observers evaluated the characteristics of the fibrous scars in the infrapatellar fat pad. All fibrous scars with low signal intensity were accentuated at the portal and coursed horizontally through the infrapatellar fat pad. The fibrous scar within the fat pad occurred and peaked within 6 months after arthroscopy. It then subsided gradually and had disappeared by one year later in nearly half of the patients. Identifying MR imaging characteristics of fibrous scars in the fat pad after arthroscopy may be clinically helpful to differentiate these scars from other abnormalities that involve the infrapatellar fat pad. (author)

  11. Fibrous dysplasia of the maxilla: diagnostic reliability of the study image. Literature review.

    Science.gov (United States)

    Fusconi, Massimo; Conte, Michela; Pagliarella, Martina; De Vincentiis, Chiara; De Virgilio, Armando; Benincasa, Anna Teresa; Alessi, Simone; Gallo, Andrea

    2013-12-01

    Objective Fibrous dysplasia (FD) is a benign bone disorder in facial bones. This study evaluates the possibility of diagnosing fibrous dysplasia on imaging alone, without biopsy of the lesion, which is often burdensome for the patient. Materials and Methods The authors bring their experience of four cases of bone lesions of the maxillofacial region and present a review of published studies. The imaging techniques evaluated are computed tomography (CT) and magnetic resonance imaging (MRI) with and without contrast. Results The literature review demonstrates that it is impossible to make diagnosis of fibrous dysplasia exclusively by imaging. Radiographic images often show a ground-glass appearance, which is characteristic but not pathognomonic of fibrous dysplasia. Conclusion Although CT and MRI images may in many cases suggest a diagnosis of fibrous dysplasia, histological examination or follow-up imaging should follow.

  12. Microstructure and properties of nano-fibrous PCL-b-PLLA scaffolds for cartilage tissue engineering

    Directory of Open Access Journals (Sweden)

    L He

    2009-10-01

    Full Text Available Nano-fibrous scaffolds which could potentially mimic the architecture of extracellular matrix (ECM have been considered a good candidate matrix for cell delivery in tissue engineering applications. In the present study, a semicrystalline diblock copolymer, poly(e-caprolactone-block-poly(L-lactide (PCL-b-PLLA, was synthesized and utilized to fabricate nano-fibrous scaffolds via a thermally induced phase separation process. Uniform nano-fibrous networks were created by quenching a PCL-b-PLLA/THF homogenous solution to -20ºC or below, followed by further gelation for 2 hours due to the presence of PLLA and PCL microcrystals. However, knot-like structures as well as continuously smooth pellicles appeared among the nano-fibrous network with increasing gelation temperature. DSC analysis indicated that the crystallization of PCL segments was interrupted by rigid PLLA segments, resulting in an amorphous phase at high gelation temperatures. Combining TIPS (thermally induced phase separation with salt-leaching methods, nano-fibrous architecture and interconnected pore structures (144±36 mm in diameter with a high porosity were created for in vitro culture of chondrocytes. Specific surface area and protein adsorption on the surface of the nano-fibrous scaffold were three times higher than on the surface of the solid-walled scaffold. Chondrocytes cultured on the nano-fibrous scaffold exhibited a spherical condrocyte-like phenotype and secreted more cartilage-like extracellular matrix (ECM than those cultured on the solid-walled scaffold. Moreover, the protein and DNA contents of cells cultured on the nano-fibrous scaffold were 1.2-1.4 times higher than those on the solid-walled scaffold. Higher expression levels of collagen II and aggrecan mRNA were induced on the nano-fibrous scaffold compared to on the solid-walled scaffold. These findings demonstrated that scaffolds with a nano-fibrous architecture could serve as superior scaffolds for cartilage tissue

  13. Axonal regeneration through the fibrous scar in lesioned goldfish spinal cord.

    Science.gov (United States)

    Takeda, A; Atobe, Y; Kadota, T; Goris, R C; Funakoshi, K

    2015-01-22

    Spontaneous nerve regeneration beyond the scar frequently occurs in fish after spinal cord lesions, in contrast to mammals. Here we examined the spatiotemporal relationship between the fibrous scar and axonal regeneration in the goldfish. Within 1 week after hemisection of the spinal cord, the open wound was closed by a fibrous scar that was demarcated from the surrounding nervous tissue by the glia limitans, which was immunoreactive for laminin. Within 1 week after hemisection, regenerating axons entered the fibrous scar, and were surrounded by laminin-coated tubular structures continuous with the glia limitans. Regenerating axons that initially entered the fibrous scar were usually accompanied by glial processes. Within 2-3 weeks after hemisection, the tubular structures became enlarged, and the regenerating axons increased in number, fasciculating in the tubules. Glial processes immunoreactive for glial fibrillary acid protein and 5-hydroxytryptamine neurons then entered the tubular structures to associate with the regenerating axons. The tubular structures developed further, creating tunnels that penetrated the fibrous scar, through which the regenerating axons passed. At 6-12 weeks after hemisection, the fibrous scar was smaller and the enlarged tunnels contained many glial processes and several axons. The findings of present study demonstrated that, following spinal lesions in goldfish, regenerating axons enter and pass the scar tissue. The regenerating axons first enter the fibrous scar with glial elements and then grow through laminin-coated tubular structures within the fibrous scar. Invasion by glial processes and neuronal elements into the tubular structures reduces the fibrous scar area and allows for more regenerating axons to pass beyond the fibrous scar.

  14. Malignant Fibrous Histiocytoma of the Breast: A Case Report

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    Dimosthenis Miliaras

    2012-01-01

    Full Text Available This paper concerns a case of Malignant Fibrous Histiocytoma (MFH of the Breast in a 73-years-old woman. A lump was found in her right breast, measuring 1.7 cm in diameter. Surgical excision followed, and pathology revealed a highly atypical spindle cell tumor. Immunohistochemistry along the histological features, excluded the possibility of carcinoma, malignant phyllodes tumor, or another type of pure sarcoma. There was no history of previous irradiation in the region. MFH is among the rarest types of sarcoma of the breast, and most of the times behaves aggressively. Excision with wide, free-of-tumor margins is the most effective treatment, when feasible.

  15. Determination of physical properties of fibrous thermal insulation

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    Jeandel G.

    2012-10-01

    Full Text Available The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a device developed in house. The radiative properties of the material are determined by an inverse method based on measurements of transmittance and reflectance using a FTIR spectrometer and by solving the equation of radiative heat transfer. These measures are compared to results of numerical simulations.

  16. Genetic engineering of fibrous proteins: spider dragline silk and collagen.

    Science.gov (United States)

    Wong Po Foo, Cheryl; Kaplan, David L

    2002-10-18

    Various strategies have been employed to genetically engineer fibrous proteins. Two examples, the subject of this review, include spider dragline silk from Nephila clavipes and collagen. These proteins are highlighted because of their unique mechanical and biological properties related to controlled release, biomaterials and tissue engineering. Cloning and expression of native genes and synthetic artificial variants of the consensus sequence repeats from the native genes has been accomplished. Expression of recombinant silk and collagen proteins has been reported in a variety of host systems, including bacteria, yeast, insect cells, plants and mammalian cells. Future utility for these proteins for biomedical materials is expected to increase as needs expand for designer materials with tailored mechanical properties and biological interactions to elicit specific responses in vitro and in vivo.

  17. Effect of microaerobic fermentation in preprocessing fibrous lignocellulosic materials.

    Science.gov (United States)

    Alattar, Manar Arica; Green, Terrence R; Henry, Jordan; Gulca, Vitalie; Tizazu, Mikias; Bergstrom, Robby; Popa, Radu

    2012-06-01

    Amending soil with organic matter is common in agricultural and logging practices. Such amendments have benefits to soil fertility and crop yields. These benefits may be increased if material is preprocessed before introduction into soil. We analyzed the efficiency of microaerobic fermentation (MF), also referred to as Bokashi, in preprocessing fibrous lignocellulosic (FLC) organic materials using varying produce amendments and leachate treatments. Adding produce amendments increased leachate production and fermentation rates and decreased the biological oxygen demand of the leachate. Continuously draining leachate without returning it to the fermentors led to acidification and decreased concentrations of polysaccharides (PS) in leachates. PS fragmentation and the production of soluble metabolites and gases stabilized in fermentors in about 2-4 weeks. About 2 % of the carbon content was lost as CO(2). PS degradation rates, upon introduction of processed materials into soil, were similar to unfermented FLC. Our results indicate that MF is insufficient for adequate preprocessing of FLC material.

  18. Hyperostotic esthesioneuroblasma: Rare variant and fibrous dysplasia mimicker

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    Ahmed, Manzoor [Neuroradiology Section, Imaging Institute, Cleveland Clinic Foundation, Cleveland (United States); Knott, Phillip Daniel [Director of Facial Plastic and Reconstructive Surgery, Associate Professor of Otolaryngology, UCSF School of Medicine, San Fransisco (United States)

    2014-02-15

    A 65-year-old male presented with a 3-year history of orbital symptoms. An imaging-based diagnosis of fibrous dysplasia involving the skull base was made at another institution. CT showed a diffuse sinonasal mass and ground-glass appearance of the bones of the anterior skull base with bony defects and mucocele formation. MRI demonstrated an accompanying intracranial and orbital rind of soft tissue mass along the hyperostotic bones. FDG-PET showed corresponding intense hypermetabolism. Small cysts were observed at the tumor-brain interface. Biopsy revealed esthesioneuroblastoma with bone infiltration that is compatible with the hyperostotic variant of esthesioneuroblastoma. There are a few cases of hyperostotic esthesioneuroblastoma reported in the literature.

  19. Determination of physical properties of fibrous thermal insulation

    Science.gov (United States)

    Tilioua, A.; Libessart, L.; Joulin, A.; Lassue, S.; Monod, B.; Jeandel, G.

    2012-10-01

    The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET) with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool) are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a device developed in house. The radiative properties of the material are determined by an inverse method based on measurements of transmittance and reflectance using a FTIR spectrometer and by solving the equation of radiative heat transfer. These measures are compared to results of numerical simulations.

  20. Focal fibrous overgrowths: a case series and review of literature.

    Science.gov (United States)

    Kolte, Abhay P; Kolte, Rajshri A; Shrirao, Tushar S

    2010-10-01

    Intraoral fibrous overgrowths of the soft tissues are relatively common and may be benign reactive or neoplastic lesions. A series of 10 lesions is presented which included pyogenic granuloma, fibroma and peripheral ossifying fibroma. Almost all the lesions occurred in the second and third decades and were present in the anterior segment of the jaws, with a distinct female predilection. Majority of these lesions were asymptomatic and the patients reported for treatment only due to the discomfort during function. Histopathologic examinations were done for diagnosis of these lesions. Surgical excision along with removal of causative irritants remains the treatment of choice. The extent of excision should depend on the severity of the lesion, as some of these lesions have a tendency for recurrence. All the patients in this series were closely followed up for a period of 2 years and showed no signs of recurrence.

  1. Focal fibrous overgrowths: A case series and review of literature

    Directory of Open Access Journals (Sweden)

    Abhay P Kolte

    2010-01-01

    Full Text Available Intraoral fibrous overgrowths of the soft tissues are relatively common and may be benign reactive or neoplastic lesions. A series of 10 lesions is presented which included pyogenic granuloma, fibroma and peripheral ossifying fibroma. Almost all the lesions occurred in the second and third decades and were present in the anterior segment of the jaws, with a distinct female predilection. Majority of these lesions were asymptomatic and the patients reported for treatment only due to the discomfort during function. Histopathologic examinations were done for diagnosis of these lesions. Surgical excision along with removal of causative irritants remains the treatment of choice. The extent of excision should depend on the severity of the lesion, as some of these lesions have a tendency for recurrence. All the patients in this series were closely followed up for a period of 2 years and showed no signs of recurrence.

  2. Case report 490: Monostotic fibrous dysplasia of the pubis

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    Buckwalter, J.A.; El-Khoury, G.; Bonfiglio, M.M.; Platz, C.C.

    1988-07-01

    An expansile lesion of the superior pubic ramus in a 32 year old man was discovered incidentally when roentgenograms were obtained to assess the possibility of fracture following an automobile accident. A technetium scan showed increased uptake in the lesion and computed tomography showed expansion of the superior pubic ramus and extension of the lesion from the pubic symphysis to the acetabulum. A needle aspirate of the lesion consisted of blood and giant cells. Based on the appearance of the lesion and the needle aspirate a preliminary diagnosis of giant cell tumor or aneurysmal bone cyst was made. When examined at the time of operation, the lesion was found to be firm and gritty. It was removed and the remaining bone surfaces curetted. Histological examination showed a pattern most consistent with fibrous dysplasia. The pubic ramus healed uneventfully.

  3. Carbon-Based Fibrous EDLC Capacitors and Supercapacitors

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    C. Lekakou

    2011-01-01

    Full Text Available This paper investigates electrochemical double-layer capacitors (EDLCs including two alternative types of carbon-based fibrous electrodes, a carbon fibre woven fabric (CWF and a multiwall carbon nanotube (CNT electrode, as well as hybrid CWF-CNT electrodes. Two types of separator membranes were also considered. An organic gel electrolyte PEO-LiCIO4-EC-THF was used to maintain a high working voltage. The capacitor cells were tested in cyclic voltammetry, charge-discharge, and impedance tests. The best separator was a glass fibre-fine pore filter. The carbon woven fabric electrode and the corresponding supercapacitor exhibited superior performance per unit area, whereas the multiwall carbon nanotube electrode and corresponding supercapacitor demonstrated excellent specific properties. The hybrid CWF-CNT electrodes did not show a combined improved performance due to the lack of carbon nanotube penetration into the carbon fibre fabric.

  4. Malignant fibrous histiocytoma presenting as hemoperitoneum mimicking hepatocellular carcinoma rupture

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Malignant fibrous histiocytoma (MFH) is a pleomorphic mesenchynal sarcoma. It is uncommonly arises primarily from the intra-peritoneal cavity. Primary peritoneal MFH with tumor bleeding and rupture is rare. We describe the imaging features of a 70-year-old patient presenting with ruptured hemorrhagic peritoneal MFH at subhepatic area, accompanied by massive hemoperitoneum,mimicking a ruptured pedunculated hepatocellular carcinoma. Computed tomography (CT) revealed a large heterogeneous enhanced subhepatic mass with adjacent liver, gallbladder and colon invasion. Tumor hemorrhage and rupture complicated with peritoneal seeding and massive bloody ascites were also detected.Angiography showed a hypervascular tumor fed by enlarged right hepatic arteries, cystic artery and omental branches of gastroepiploic artery. The patient underwent laparotomy for tumor resection, but the tumor recurred one month after operation. To our knowledge, the CT appearance of ruptured intraperitoneal MFH complicated by hemoperitoneum has not been previously described.

  5. Solitary fibrous tumor of the pleura: 3 case reports

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    Elias Amorim

    2015-06-01

    Full Text Available Summary Introduction: solitary fibrous tumor of the pleura (SFTP is a rare tumor arising from mesenchymatous cells in submesothelial pleural tissue which, unlike mesothelioma, is not related to asbestos or smoking. Methods: report of four patients who underwent surgical treatment for giant SFTP and review of the pertinent literature. Results: of the four patients operated, two presented symptoms including cough, chest pain and feeling of compression, whereas the other two subjects were asymptomatic. All patients underwent complete surgical resection by wide posterolateral thoracotomy, and surgical specimens removed with minimum bleeding. None of the cases required complementary lobectomy or segmentectomy. All tumors were histologically benign. Conclusion: complete resection of the lesion is the treatment of choice in all SFTP cases. Prognosis of the benign lesion is excellent, although close follow-up is necessary. In the rarer, more aggressive forms, treatment may be complemented by adjunctive chemotherapy or radiotherapy, the benefits of which have yet to be confirmed.

  6. Malignant fibrous histiocytoma of the lower lip: A case report

    Directory of Open Access Journals (Sweden)

    Pechalova Petia F

    2012-03-01

    Full Text Available Malignant fibrous histiocytoma (MFH represents the diagnosis that is still commonly used by both patients and physicians although in 2002., the World Health Organization (WHO declassified MFH as a formal diagnostic entity, renaming it as an undifferentiated pleomorphic sarcoma not specifying it further. MFH is extremely rare in the oral cavity. The aim of this article was to describe a newly diagnosed case of primary MFH in a 78-year-old male presented after 4-months history of rapidly increasing swelling of lower lip. Histopathology of the lesion showed highly malignant cell infiltration with epithelioid/spindle cell type morphology. Immunohistochemical study was positive for vimentin (++, S-100 protein (++ and negative for desmin and cytokeratin. The authors discussed the possibilities of immunohistochemical study and necessity of individual treatment plan in patients with MFH, comparing their point of view with other studies.

  7. Stabilized Lateritic Blocks Reinforced With Fibrous Coir Wastes

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    M G Sreekumar

    2013-11-01

    Full Text Available Tropical countries are rich in lateritic soil, a naturally available raw material for building construction. But its potential in block making is not yet satisfactorily explored. This paper focuses on an experimental investigation for improvising stabilized lateritic blocks (SLB with coir cutting wastes from coir industry as reinforcing elements. Lateritic soil used in this study showed a higher percentage of clay content. Hence it was pre-stabilized with sand and cement. Blocks were prepared by stabilizing it further with waste fibrous additives and tested for strength and durability. Considerable improvement in strength (compressive strength @19% and tensile strength @ 9% and durability characteristics were exhibited by the new fiber reinforced lateritic blocks (FRLB with fiber content of 0.5%. These blocks can be successfully proposed for load bearing construction and as well as for earthquake resistant structures

  8. Calcifying fibrous pseudotumor of pleura: radiologic features in three cases.

    Science.gov (United States)

    Erasmus, J J; McAdams, H P; Patz, E F; Murray, J G; Pinkard, N B

    1996-01-01

    Our goal was to describe the radiologic features of calcifying fibrous pseudotumor (CEPT) of pleura. Chest radiographs and CT images of three patients, aged 23-34 years, with pathologically proven CFPT of pleura were reviewed with regard to lesion size, location, and appearance. Chest radiographs showed well marginated, noncalcified pleural masses in all cases. Two patients had solitary masses and one had multifocal ipsilateral masses. All masses were located in the inferior aspect of the chest and measured 3-12 cm. All masses were calcified on CT. The calcifications were thick and band-like in two cases and punctate in one. There was no chest wall invasion, pleural effusion, or parenchymal disease. CFPTs of pleura are rare lesions that manifest as calcified pleural masses in young adults.

  9. An Empirical Formula for Sound Absorption of Fibrous Materials

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xin-an

    2008-01-01

    The sound absorption coefficient (SAC) curves of the nonwovens, fabrics, and thick fibrous layers with the frequency in the range of 125-3 200 Hz and cavity distances of 5 cm, 10 cm, 20 cm, 30 cm and 40 cm were measured.Based on analysis, it is found that the SAC is actually in direct proportion to the relative vibration amplitude of the sound wave, resulting in obtaining a mathematical expression showing that the SAC changes with the frequency for a given material. Additionally, a good corresponding relation between the maximal SAC and the permeability of the materials is discovered, thus an empirical formula is established. As a result, a complete SAC formula has been developed. In this formula, the SAC is solely a function of the sound wave frequency and permeability of the material. In comparison with sound absorption spectra of several materials, the calculated results and results measured with the formula coincide well with each other.

  10. [Solitary fibrous tumor of the pelvis: a rare extrathoracic manifestation].

    Science.gov (United States)

    Gessmann, J; Seybold, D; Helwing, M; Muhr, G; Schildhauer, T A

    2009-07-01

    Solitary fibrous tumors (SFT) are rare spindle cell neoplasms. To date only very few cases of pelvic SFT have been reported in the literature. SFT are characterized by unique microscopic and immunohistochemical findings. Complete local resection is the treatment of choice. Recurrence and metastasis may be related to infrequent malignant histological features, but histology is not always a reliable predictor for prognosis. Therefore long-term follow-up is necessary.We report about a male patient with a malignant pelvic SFT. After complete resection the tumor recurred after a short period of 6 months posterior to the original location in the pelvis. The differential diagnoses and the therapy options are discussed with a review of the present literature.

  11. A theoretical analysis of local thermal equilibrium in fibrous materials

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    Tian Mingwei

    2015-01-01

    Full Text Available The internal heat exchange between each phase and the Local Thermal Equilibrium (LTE scenarios in multi-phase fibrous materials are considered in this paper. Based on the two-phase heat transfer model, a criterion is proposed to evaluate the LTE condition, using derived characteristic parameters. Furthermore, the LTE situations in isothermal/adiabatic boundary cases with two different heat sources (constant heat flux and constant temperature are assessed as special transient cases to test the proposed criterion system, and the influence of such different cases on their LTE status are elucidated. In addition, it is demonstrated that even the convective boundary problems can be generally estimated using this approach. Finally, effects on LTE of the material properties (thermal conductivity, volumetric heat capacity of each phase, sample porosity and pore hydraulic radius are investigated, illustrated and discussed in our study.

  12. The Surface Groups and Active Site of Fibrous Mineral Materials

    Institute of Scientific and Technical Information of China (English)

    DONG Fa-qin; WAN Pu; FENG Qi-ming; SONG Gong-bao; PENG Tong-jiang; LI Ping; LI Guo-wu

    2004-01-01

    The exposed and transformed groups of fibrous brucite,wollastonite,chrysotile asbestos,sepiolite,palygorskite,clinoptilolite,crocidolite and diatomaceous earth mineral materials are analyzed by IR spectra after acid and alikali etching,strong mechanical and polarity molecular interaction.The results show the active sites concentrate on the ends in stick mineral materials and on the defect or hole edge in pipe mineral materials.The inside active site of mineral materials plays a main role in small molecular substance.The shape of minerals influence their distribution and density of active site.The strong mechanical impulsion and weak chemical force change the active site feature of minerals,the powder process enables minerals exposed more surface group and more combined types.The surface processing with the small polarity molecular or the brand of middle molecular may produce ionation and new coordinate bond,and change the active properties and level of original mineral materials.

  13. Non-fibrous inorganic particles in human bronchoalveolar lavage fluids.

    Science.gov (United States)

    Dumortier, P; De Vuyst, P; Yernault, J C

    1989-12-01

    Bronchoalveolar lavage (BAL) is a simple and non-invasive sampling technique of the deep lung. Analytical electron microscopy was used for the identification and quantification of non-fibrous inorganic particles recovered in BAL fluid samples from 51 subjects with various occupational exposures (silica, silicates, metals and alloys, metallic oxides, precious and hard metals, abrasives). Around 4750 particles were analysed. More than sixty different compounds were identified, among which silica, kaolinite, illite, mica, Fe oxides and hydroxides, appeared to be ubiquitous. Feldspar, talc, chlorite, Al oxide, Ti oxide, tungsten carbide, stainless steel, carbonaceous compounds and flyash were also frequently encountered. From 1 to 21 compounds were identified in each sample. Repeated BAL samples obtained for 2 subjects did not show significant differences. Particles characteristic of the occupational exposure were found in BAL up to 21 years after cessation. BAL content can also reflect mixed occupational exposures. Absolute particle concentrations measured in twelve samples ranged between 0.1 and 9.9 x 10(6) particles/ml BAL fluid and mean particle diameter ranged between 0.5 and 1.2 microns. Mineralogical analysis of non-fibrous particles in BAL can be a useful tool to investigate occupational exposures. It allows, in most cases, a better characterization of the exposure than medical questioning. It may be helpful in identifying pathogenic particles, however it must be kept in mind that a positive result is only a proof of exposure and never a proof of disease. The main limitations of this technique are difficulties in sampling severely diseased subjects and inaccuracy in detecting easily soluble compounds and particles with a high rate of alveolar clearance.

  14. Creation of Hybrid Nanorods From Sequences of Natural Trimeric Fibrous Proteins Using the Fibritin Trimerization Motif

    Science.gov (United States)

    Papanikolopoulou, Katerina; van Raaij, Mark J.; Mitraki, Anna

    Stable, artificial fibrous proteins that can be functionalized open new avenues in fields such as bionanomaterials design and fiber engineering. An important source of inspiration for the creation of such proteins are natural fibrous proteins such as collagen, elastin, insect silks, and fibers from phages and viruses. The fibrous parts of this last class of proteins usually adopt trimeric, β-stranded structural folds and are appended to globular, receptor-binding domains. It has been recently shown that the globular domains are essential for correct folding and trimerization and can be successfully substituted by a very small (27-amino acid) trimerization motif from phage T4 fibritin. The hybrid proteins are correctly folded nanorods that can withstand extreme conditions. When the fibrous part derives from the adenovirus fiber shaft, different tissue-targeting specificities can be engineered into the hybrid proteins, which therefore can be used as gene therapy vectors. The integration of such stable nanorods in devices is also a big challenge in the field of biomechanical design. The fibritin foldon domain is a versatile trimerization motif and can be combined with a variety of fibrous motifs, such as coiled-coil, collagenous, and triple β-stranded motifs, provided the appropriate linkers are used. The combination of different motifs within the same fibrous molecule to create stable rods with multiple functions can even be envisioned. We provide a comprehensive overview of the experimental procedures used for designing, creating, and characterizing hybrid fibrous nanorods using the fibritin trimerization motif.

  15. Radiographic Differential Diagnosis Between The Fibrous Dysplasia And The Ossifying Fibroma

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Karp Shik [Dept. of Dental Radiology, College of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    1999-02-15

    The author observed and compared the radiographic features of 49 cases of the fibrous dysplasia and 14 cases of the ossifying fibroma in the osteoblastic or mature stage radiologically and histopathologically. The obtained results were as follows: 1. Fibrous dysplasia occurred most frequently in the 2nd decade, but ossifying fibroma in the 3rd and 4th decades, and both lesions occurred with slight predilection in females. 2. In most cases, chief complaints were painless facial swelling. And 61.1% of fibrous dysplasia occurred in the maxilla, 92.9% of ossifying fibroma in the mandible, and most of these lesions occurred in the premolar-molar region. 3. In the mandibular lesions, ossifying fibroma was shown more oval and round shape, but fibrous dysplasia was shown fusiform shape. 4. Fibrous dysplasia was shown homogeneously distributed, complete radiopaque shadow at 63%, and ossifying fibroma was shown concentric, mixed appearance of radiolucent and radiopaque shadow at 92.9%. 5. Fibrous dysplasia was entirely shown poorly outlined and blended to normal surrounding bone, but ossifying fibroma was shown well-defined border. 6. Cortical thinning and expansion were observed in these lesions, but degree of cortical expansion was more severe in ossifying fibroma than fibrous dysplasia. 7. Loss of lamina dura, tooth displacement, and displacement of mandibular canal were observed in both lesions, but root resorption was observed in ossifying fibroma only.

  16. Fibrous capsule formation of the peritoneal catheter tip in ventriculoperitoneal shunt: Two case reports

    Directory of Open Access Journals (Sweden)

    Tomoaki Kano

    2014-01-01

    Full Text Available Background: A fibrous capsule formation of a peritoneal catheter tip has not previously been researched as a complication of ventriculoperitoneal (VP shunts. Case Description: Two adult patients who had undergone a VP shunt for communicative hydrocephalus following subarachnoid hemorrhage caused by a ruptured aneurysm have been identified with malfunction of the VP shunt system by mild disturbance of consciousness and gait disturbance or loss of appetite. Hydrocephalus was diagnosed by computed tomography and the obstruction of the peritoneal catheter was revealed by shuntgraphy. Laparoscopy was performed and the peritoneal catheter tips were obstructed by fibrous white capsules that covered them. One was a thin membranous capsule like a stocking with two small endoluminal granulomas of the peritoneal catheter, and other one was a fibrous glossy white capsule like a sock. These fibrous capsules were excised by laparoscopy forceps without the conversion to a new peritoneal catheter. Following the procedure, the shunt functioned normally. The pathological diagnoses were peritoneum with foreign body reaction or hyalinization of membranous tissue surrounded by fibrous tissue. Conclusion: These fibrous capsules might be formed by the peritoneal reaction to cerebrospinal fluid as a foreign material. As such, a periodic medical check should be scheduled since a fibrous capsule of the peritoneal catheter tip might be formed again.

  17. A large infiltrating fibrous hamartoma of infancy in the abdominal wall with rare associated tuberous sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Han, Hye-Jeong; Lim, Gye-Yeon [The Catholic University of Korea, Department of Radiology, St. Mary' s Hospital, Seoul (Korea); You, Chang-Young [The Catholic University of Korea, Department of Pathology, St. Mary' s Hospital, Seoul (Korea)

    2009-07-15

    Tuberous sclerosis is a complex autosomal-dominant neurocutaneous syndrome characterized by hamartomatous malformations of fibrous and connective tissues in various organs. Although various histologic types of soft-tissue masses can occur with tuberous sclerosis, we present a unique case of fibrous hamartoma of infancy presenting as large infiltrating cutaneous and subcutaneous masses in the abdominal wall in a 4-year-old boy with tuberous sclerosis. Although the co-occurrence of tuberous sclerosis and fibrous hamartoma of infancy is very rare, it should be considered in the differential diagnosis of subcutaneous soft-tissue masses found in children with tuberous sclerosis. (orig.)

  18. Fibrous Myopathy as a Complication of Repeated Intramuscular Injections for Chronic Headache

    Directory of Open Access Journals (Sweden)

    R Burnham

    2006-01-01

    Full Text Available Two cases of fibrous myopathy associated with repeated, long-term intramuscular injections for treatment of chronic temporomandibular joint pain and chronic headache, respectively, are described. Both patients developed severe, function-limiting contractures in upper and lower extremity muscles used as injection sites. In one of the cases, the contractures were painful. Electrophysiological testing, magnetic resonance imaging and muscle biopsy results were all consistent with myopathy and replacement of skeletal muscle with noncontractile fibrous tissue. These cases are presented to increase awareness of fibrous myopathy and to promote surveillance for this serious potential complication of long-term intramuscular injections in chronic headache and other pain patients.

  19. Case report 557: Solitary intramuscular myxoma in a patient with polyostotic fibrous dysplacia

    Energy Technology Data Exchange (ETDEWEB)

    Glass-Royal, M.C.; Nelson, M.C.; Albert, F.; Lack, E.E.; Bogumill, G.P. (Georgetown Univ., Washington, DC (USA). Medical Center)

    1989-08-01

    We report a case of solitary intramuscular myxoma in a patient with polyostotic fibrous dysplasia and pigmented macules. MR played an important role in the patient's pre-operative evaluation. It has been demonstrated in a review of the literature that a definite relationship exists between myxoma of soft tissues and fibrous dysplasia of the skeleton. Multiple myxomas in a patient with fibrous dysplasia are common and a relationship also exists between myxoma of the soft tissues and the McCune-Albright syndrome. (orig./GDG).

  20. Congenital costo-vertebral fibrous band and congenital kyphoscoliosis: a previously unreported combination.

    Science.gov (United States)

    Eid, Tony; Ghostine, Bachir; Kreichaty, Gaby; Daher, Paul; Ghanem, Ismat

    2013-05-01

    Congenital kyphoscoliosis (CKS) results from abnormal vertebral chondrification. Congenital fibrous bands occur in several locations with variable impact on vertebral development. We report a previously unreported case of a female infant with CKS presenting with an L2 hypoplastic vertebra and a costo-vertebral fibrous band extending to the skin in the form of a dimple. We also describe the therapeutic approach, consisting of surgical excision of the fibrous band and postoperative fulltime bracing, with a 7-year follow-up. We recommend a high index of suspicion in any unusual presentation of CKS and insist on case by case management in such cases.

  1. An ancillary CT finding of intrapulmonary solitary fibrous tumor: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Jun; Rho, Ji Young; Kwon, Ah Young [CHA Bundang Medical Center, CHA University, Seongnam (Korea, Republic of)

    2017-02-15

    Intrapulmonary solitary fibrous tumor is extremely rare. A few reports have presented typical CT findings such as well-defined, variable—sized, heterogeneously or homogenously well-enhanced intrapulmonary nodules. We report herein a rare case of intrapulmonary solitary fibrous tumor that showed typical clinical and CT features, and we also provide an ancillary CT finding that shows a distinguishable tubular vascular structure within the nodule. The tubular vascular structure was conjoined to the proximal pulmonary vein. In this study, we highlight an ancillary CT finding reported for the first time for the diagnosis of a patient with intrapulmonary solitary fibrous tumor.

  2. Preparation and Properties of Friction Materials by Using Two Kinds of Fibrous Industrial Minerals

    Institute of Scientific and Technical Information of China (English)

    SHEN Shang-yue; HU Shan; LI Zhen; ZHANG De; LIU Xin-hai; SONG Xu-bo

    2003-01-01

    The basic technology and properties of the brake blocks made of modified needle-like wollastonite and fibrous sepiolite were intensively researched.The impact strengthes and fixed velocity friction of the brake blocks prepared by different recipes were tested. The testing results show that it is feasible for needle-like wollastonite and fibrous sepiolite to take the place of asbestos as the reinforced materials of friction materials.The braking effect of the brake blocks is the best when the ratio of the needle-like wollastonite to the fibrous sepiolite was 1∶6.

  3. Fibrous Dysplasia Mimicking Malignancy on 68Ga-DOTATATE PET/CT.

    Science.gov (United States)

    Papadakis, Georgios Z; Millo, Corina; Sadowski, Samira M; Karantanas, Apostolos H; Bagci, Ulas; Patronas, Nicholas J

    2017-03-01

    Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on Ga-DOTATATE PET/CT. The presented data indicate cell surface overexpression of somatostatin receptors by fibrous dysplastic cells and highlight the need of cautious management of Ga-DOTATATE-avid bone lesions, which could mimic malignancy especially in patients with history of neuroendocrine tumors.

  4. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Rigali

    2001-10-01

    Published mechanical and thermal properties data on a variety of materials was gathered, with focus on materials that have potential with respect to developing wear resistant and damage tolerant composite for mining industry applications. Preliminary core materials of interest include but are not limited to: Diamond, Tungsten Carbide and Cemented Tungsten Carbides, Carbides of Boron, Silicon, Titanium and Aluminum, Diboride of Titanium and Aluminum, Nitrides of Aluminum, Silicon, Titanium, and Boron, Aluminum Oxide, Tungsten, Titanium, Iron, Cobalt and Metal Alloys. Preliminary boundary materials of interest include but are not limited to: W metal, WC-Co, W-Co, WFeNi, and Mo metal and alloys. Several FM test coupons were fabricated with various compositions using the above listed materials. These coupons were consolidated to varying degrees by uniaxial hot pressing, then cut and ground to expose the FM cell structure. One promising system, WC-Co core and WFeNi boundary, was consolidated to 97% of theoretical density, and demonstrates excellent hardness. Data on standard mechanical tests was gathered, and tests will begin on the consolidated test coupons during the upcoming reporting period. The program statements of work for ACR Inc. and its subcontractors, as well as the final contract negotiations, were finalized during the current reporting period. The program start date was February 22nd, 2001. In addition to the current subcontractors, Kennametal Inc., a major manufacturer of cutting tools and wear resistant tooling for the mining industry, expressed considerable interest in ACR's Fibrous Monolith composites for both machine and mining applications. At the request of Kennametal, ARC Inc fabricated and delivered several Fibrous Monolith coupons and components for testing and evaluation in the mining and machine tool applications. Additional samples of Diamond/Tungsten Carbide-6%Cobalt Fibrous Monolith were fabricated and delivered for testing Kennametal

  5. Meurigite, a new fibrous iron phosphate resembling kidwellite

    Science.gov (United States)

    Birch, W.D.; Pring, A.; Self, P.G.; Gibbs, R.B.; Keck, E.; Jensen, M.C.; Foord, E.E.

    1996-01-01

    Meurigite is a new hydrated potassium iron phosphate related to kidwellite and with structural similarities to other late-stage fibrous ferric phosphate species. It has been found at four localities so far - the Santa Rita mine, New Mexico, U.S.A.; the Hagendorf-Sud pegmatite in Bavaria, Germany; granite pegmatite veins at Wycheproof, Victoria. Australia; and at the Gold Quarry Mine, Nevada, U.S.A. The Santa Rita mine is the designated type locality. Meurigite occurs as tabular, elongated crystals forming spherical and hemispherical clusters and drusy coatings. The colour ranges from creamy white to pale yellow and yellowish brown. At the type locality, the hemispheres may reach 2 mm across, but the maximum diameter reached in the other occurrences is usually less than 0.5 mm. A wide variety of secondary phosphate minerals accompanies meurigite at each locality, with dufrenite, cyrilovite. beraunite, rockbridgeite and leucophosphite amongst the most common. Vanadates and uranates occur with meurigite at the Gold Quarry mine. Electron microprobe analysis and separate determination of H2O and CO2 on meurigite from the type locality gave a composition for which several empirical formulae could be calculated. The preferred formula, obtained on the basis of 35 oxygen atoms, is (K0.85Na0.03)??0.88(Fe7.013+Al0.16Cu0.02)??7.19 (PO4)5.11(CO3)0.20(OH) 6.7??7-7.25H2O, which simplifies to KFe73+(PO4)5(OH) 7??8H2O. Qualitative analyses only were obtained for meurigite from the other localities, due to the softness and openness of the aggregates. Because of the fibrous nature of meurigite, it was not possible to determine the crystal structure, hence the exact stoichiometry remains uncertain. The lustre of meurigite varies from vitreous to waxy for the Santa Rita mine mineral, to silky for the more open sprays and internal surfaces elsewhere. The streak is very pale yellow to cream and the estimated Mohs hardness is about 3. Cleavage is perfect on {001] and fragments from the

  6. In vitro biocompatibility of schwann cells on surfaces of biocompatible polymeric electrospun fibrous and solution-cast film scaffolds.

    Science.gov (United States)

    Sangsanoh, Pakakrong; Waleetorncheepsawat, Suchada; Suwantong, Orawan; Wutticharoenmongkol, Patcharaporn; Weeranantanapan, Oratai; Chuenjitbuntaworn, Boontharika; Cheepsunthorn, Poonlarp; Pavasant, Prasit; Supaphol, Pitt

    2007-05-01

    The in vitro responses of Schwann cells (RT4-D6P2T, a schwannoma cell line derived from a chemically induced rat peripheral neurotumor) on various types of electrospun fibrous scaffolds of some commercially available biocompatible and biodegradable polymers, i.e., poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), polycaprolactone (PCL), poly(l-lactic acid) (PLLA), and chitosan (CS), were reported in comparison with those of the cells on corresponding solution-cast film scaffolds as well as on a tissue-culture polystyrene plate (TCPS), used as the positive control. At 24 h after cell seeding, the viability of the attached cells on the various substrates could be ranked as follows: PCL film > TCPS > PCL fibrous > PLLA fibrous > PHBV film > CS fibrous approximately CS film approximately PLLA film > PHB film > PHBV fibrous > PHB fibrous. At day 3 of cell culture, the viability of the proliferated cells on the various substrates could be ranked as follows: TCPS > PHBV film > PLLA film > PCL film > PLLA fibrous > PHB film approximately PCL fibrous > CS fibrous > CS film > PHB fibrous > PHBV fibrous. At approximately 8 h after cell seeding, the cells on the flat surfaces of all of the film scaffolds and that of the PCL nanofibrous scaffold appeared in their characteristic spindle shape, while those on the surfaces of the PHB, PHBV, and PLLA macrofibrous scaffolds also appeared in their characteristic spindle shape, but with the cells being able to penetrate to the inner side of the scaffolds.

  7. Giant solitary fibrous tumor arising from greater omentum

    Institute of Scientific and Technical Information of China (English)

    Liang Zong; Ping Chen; Guang-Yao Wang; Qun-Shan Zhu

    2012-01-01

    Extrathoracic solitary fibrous tumors (SFTs) have been described at almost every anatomic location of human body,but reports of SFT in the abdominal cavity are rare.We herein present a rare case of SFT originating from greater omentum.Computed tomography revealed a 15.8 cm x 21.0 cm solid mass located at superior aspect of stomach.Open laparotomy confirmed its mesenchymal origin.Microscopically,its tissue was composed of non-organized and spindle-shaped cells exhibiting atypical nuclei,which were divided up by branching vessel and collagen bundles.Immunohistochemical staining showed that this tumor was negative for CD117,CD99,CD68,cytokeratin,calretinin,desmin,epithelial membrane antigen,F8 and S-100,but positive for CD34,bcl-2,α-smooth muscle actin and vimentin.The patient presented no evidence of recurrence during follow-up.SFT arising from abdominal cavity can be diagnosed by histological findings and immunohistochemical markers,especially for CD34 and bcl-2 positive cases.

  8. Fast numerical upscaling of heat equation for fibrous materials

    KAUST Repository

    Iliev, Oleg

    2010-08-01

    We are interested in numerical methods for computing the effective heat conductivities of fibrous insulation materials, such as glass or mineral wool, characterized by low solid volume fractions and high contrasts, i.e., high ratios between the thermal conductivities of the fibers and the surrounding air. We consider a fast numerical method for solving some auxiliary cell problems appearing in this upscaling procedure. The auxiliary problems are boundary value problems of the steady-state heat equation in a representative elementary volume occupied by fibers and air. We make a simplification by replacing these problems with appropriate boundary value problems in the domain occupied by the fibers only. Finally, the obtained problems are further simplified by taking advantage of the slender shape of the fibers and assuming that they form a network. A discretization on the graph defined by the fibers is presented and error estimates are provided. The resulting algorithm is discussed and the accuracy and the performance of the method are illusrated on a number of numerical experiments. © Springer-Verlag 2010.

  9. Fibrous adsorbent for removal of aqueous aromatic hydrocarbons.

    Science.gov (United States)

    Jung, Yong-Jun; Kiso, Yoshiaki; Oguchi, Tatsuo; Yamada, Toshiro; Takagi, Hiroo; Nishimura, Kazuyuki

    2007-01-01

    Bundles of a strongly hydrophobic fibrous material (p-phenylene-2,6-benzobisoxazole; PBO; Zylon) were employed as an adsorbent for the removal of aqueous aromatic compounds, because the PBO fibers are too rigid to be woven and did not entrap suspended solids. The removal performance for nine kinds of polyaromatic hydrocarbons (PAHs) and di-(2-ethylhexyl) phthalate (DEHP) was evaluated. PAHs and DEHP at initial concentrations of 50 microg L(-1) were removed at 72.5-99.9% and ca. 95%, respectively, although the removal efficiencies were affected by the phase ratio (fiber weight/solution volume). The logarithm of the partition coefficient (log K) for planar PAHs was linearly correlated with the logarithm of the n-octanol/water partition coefficient (log P), but nonplanar PAHs, such as cis-stilbene, p-terphenyl, and o-terphenyl, showed significantly lower adsorption performance. The adsorbed PAHs were not desorbed effectively with CH3CN, CH2Cl2, and toluene. On the other hand, DEHP was effectively desorbed with methanol.

  10. Applications of fibrous substrates containing insolubilized phase change polymers

    Science.gov (United States)

    Vigo, Tyrone L.; Bruno, Joseph S.

    1993-01-01

    Incorporation of polyethylene glycols into fibrous substrates produces several improved functional properties when they are insolubilized by crosslinking with a methylolamide resin or by polyacetal formation by their reaction with glyoxal. The range of molecular weights of polyols that may be insolubilized is broad as are the curing conditions (0.25-10 min at 80-200C). Most representative fiber types and blends (natural and synthetic) and all types of fabric constructions (woven, nonwoven and knit) have been modified by incorporation of the bound polyols. The most novel property is the thermal adaptability of the modified substrates to many climatic conditions. This adaptability is due to the high latent heat of the crosslinked polyols that function as phase change materials, the hydrophilic nature of the crosslinked polymer and its enhanced thermal conductivity. Other enhanced properties imparted to fabrics include flex and flat abrasion, antimicrobial activity, reduced static charge, resistance to oily soils, resiliency, wind resistance and reduced lint loss. Applications commercialized in the U.S. and Japan include sportswear and skiwear. Several examples of electric sets of properties useful for specific end uses are given. In addition, other uses are biomedical horticultural, aerospace, indoor insulation, automotive interiors and components and packaging material.

  11. Strength and deformation characteristics of steel fibrous concrete beams

    Institute of Scientific and Technical Information of China (English)

    SINGH Bhupinder; SINGH S.P.; KAUSHIK S.K.

    2007-01-01

    The results of an analytical investigation of the flexural behaviour of Steel Fibre Reinforced Concrete (SFRC) beams are presented. The complete response of the SFRC beams under displacement controlled static loading was obtained using nonlinear Finite Element (FE) techniques implemented with the help ofATENA 2D software. Issues relating to the behaviour of SFRC which have a direct bearing on the FE modelling are discussed with relevance to the software employed for the nonlinear analysis. Constitutive models amenable to numerical analysis for steel fibrous concrete are presented. The structural response throughout the loading regime was captured in terms of the load-deflection behaviour, which in addition to the post-peak response characterized the failure mode of the test beams. The crack patterns at crack initiation and at the end of the tests were also recorded. Experimental results from the specimens of two other investigators were used as control values for this investigation. The response of the specimens of this investigation was evaluated in terms of initial tangent stiffness, peak loads and toughness. Good match was obtained between the results from this investigation and corresponding experimentally obtained values, wherever available.The influence of the fibre content is reflected in the observed trends in peak loads, deflection at peak loads and toughness, which are in broad agreement with known behavioral patterns of SFRC.

  12. De novo malignant solitary fibrous tumor of the kidney

    Directory of Open Access Journals (Sweden)

    Chen Siu-Chung

    2011-10-01

    Full Text Available Abstract The kidney is a relatively infrequent site for solitary fibrous tumor (SFT. Among the previously reported cases, only two cases of malignant renal SFT developing via dedifferentiation from a pre-existing benign SFT have been reported. Here we reported a case of de novo malignant renal SFT clinically diagnosed as renal cell carcinoma in a 50-year-old woman. The tumor was circumscribed but unencapsulated and showed obvious hemorrhagic necrosis. Microscopically, the tumor was composed of patternless sheets of alternating hypercellular and hypocellular areas of spindle cells displaying mild to moderate nuclear atypia, frequent mitoses up to 8 per 10 high power fields, and a 20% Ki-67 proliferative index. Immunohistochemical studies revealed reactivity for CD34, CD99 and vimentin, with no staining for all other markers, confirming the diagnosis of SFT. No areas of dedifferentiation were seen after extensive sampling. Based on the pathologic and immunohistochemical features, a diagnosis of de novo malignant renal SFT was warranted. Our report expands the spectrum of malignant progression in renal SFTs. Even though this patient has been disease-free for 30 months, long-term follow-up is still mandatory.

  13. De novo malignant solitary fibrous tumor of the kidney.

    Science.gov (United States)

    Hsieh, Tsan-Yu; ChangChien, Yi-Che; Chen, Wen-Hsiang; Chen, Siu-Chung; Chang, Liang-Che; Hwang, Cheng-Cheng; Chein, Hui-Ping; Chen, Jim-Ray

    2011-10-05

    The kidney is a relatively infrequent site for solitary fibrous tumor (SFT). Among the previously reported cases, only two cases of malignant renal SFT developing via dedifferentiation from a pre-existing benign SFT have been reported. Here we reported a case of de novo malignant renal SFT clinically diagnosed as renal cell carcinoma in a 50-year-old woman. The tumor was circumscribed but unencapsulated and showed obvious hemorrhagic necrosis. Microscopically, the tumor was composed of patternless sheets of alternating hypercellular and hypocellular areas of spindle cells displaying mild to moderate nuclear atypia, frequent mitoses up to 8 per 10 high power fields, and a 20% Ki-67 proliferative index. Immunohistochemical studies revealed reactivity for CD34, CD99 and vimentin, with no staining for all other markers, confirming the diagnosis of SFT. No areas of dedifferentiation were seen after extensive sampling. Based on the pathologic and immunohistochemical features, a diagnosis of de novo malignant renal SFT was warranted. Our report expands the spectrum of malignant progression in renal SFTs. Even though this patient has been disease-free for 30 months, long-term follow-up is still mandatory.

  14. Fractal Model for Acoustic Absorbing of Porous Fibrous Metal Materials

    Directory of Open Access Journals (Sweden)

    Weihua Chen

    2016-01-01

    Full Text Available To investigate the changing rules between sound absorbing performance and geometrical parameters of porous fibrous metal materials (PFMMs, this paper presents a fractal acoustic model by incorporating the static flow resistivity based on Biot-Allard model. Static flow resistivity is essential for an accurate assessment of the acoustic performance of the PFMM. However, it is quite difficult to evaluate the static flow resistivity from the microstructure of the PFMM because of a large number of disordered pores. In order to overcome this difficulty, we firstly established a static flow resistivity formula for the PFMM based on fractal theory. Secondly, a fractal acoustic model was derived on the basis of the static flow resistivity formula. The sound absorption coefficients calculated by the presented acoustic model were validated by the values of Biot-Allard model and experimental data. Finally, the variation of the surface acoustic impedance, the complex wave number, and the sound absorption coefficient with the fractal dimensions were discussed. The research results can reveal the relationship between sound absorption and geometrical parameters and provide a basis for improving the sound absorption capability of the PFMMs.

  15. [A case of solitary fibrous tumor in the sella turcica].

    Science.gov (United States)

    Shimizu, Kiyoharu; Tominaga, Atsushi; Kinoshita, Yasuyuki; Usui, Satoshi; Sugiyama, Kazuhiko; Kurisu, Kaoru

    2013-10-01

    A 64-year-old male presented with an incidental tumor in the sella turcica during a brain medical checkup. Because he lacked any neurological symptoms or signs of pituitary dysfunction, the patient did not undergo surgery. Three years later, visual disturbances developed, including poor eyesight and visual field defects. The response to the growth hormone(GH)releasing peptide-2 demonstrated severe GH deficiency. MRI revealed an enlarged tumor appearing as a mosaic pattern of high and very low intensity on T2-weighted imaging. The region of very low intensity on T2-weighted imaging exhibited enhancement after T1 gadolinium-DTPA administration. The tumor was totally removed via the microscopic trans-sphenoidal approach in combination with endoscopic observation. The hard tumor adhered to the dura of the sella turcica and the medial wall of the left cavernous sinus. Histological verification confirmed a solitary fibrous tumor(SFT). Fourteen months after the operation, MRI revealed no recurrent tumors. SFT infrequently occurs in the sella turcica; however it should be included in the differential diagnosis in cases of enhanced tumors with marked low intensity on T2-weighted imaging.

  16. A Study of Failure Criteria of Fibrous Composite Materials

    Science.gov (United States)

    Paris, Federico; Jackson, Karen E. (Technical Monitor)

    2001-01-01

    The research described in this paper is focused on two areas: (1) evaluation of existing composite failure criteria in the nonlinear, explicit transient dynamic finite element code, MSC.Dytran, and (2) exploration of the possibilities for modification of material and failure models to account for large deformations, progressive failure, and interaction of damage accumulation with stress/strain response of laminated composites. Following a review of the MSC.Dytran user manual, a bibliographical review of existing failure criteria of composites was performed. The papers considered most interesting for the objective of this report are discussed in section 2. The failure criteria included in the code under consideration are discussed in section 3. A critical summary of the present procedures to perform analysis and design of composites is presented in section 4. A study of the most important historical failure criteria for fibrous composite materials and some of the more recent modifications proposed were studied. The result of this analysis highlighted inadequacies in the existing failure criteria and the need to perform some numerical analyses to elucidate the answer to questions on which some of the proposed criteria are based. A summary of these ideas, which is a proposal of studies to be developed, is presented in section 5. Finally, some ideas for future developments are summarized in section 6.

  17. Properties of nanoparticles affecting simulation of fibrous gas filter performance

    Science.gov (United States)

    Tronville, Paolo; Rivers, Richard

    2015-05-01

    Computational Fluid Dynamics (CFD) codes allow detailed simulation of the flow of gases through fibrous filter media. When the pattern of gas flow between fibers has been established, simulated particles of any desired size can be “injected” into the entering gas stream, and their paths under the influence of aerodynamic drag, Brownian motion and electrostatic forces tracked. Particles either collide with a fiber, or pass through the entire filter medium. They may bounce off the fiber surface, or adhere firmly to the surface or to particles previously captured. Simulated injection of many particles at random locations in the entering stream allows the average probability of capture to be calculated. Many particle properties must be available as parameters for the equations defining the forces on particles in the gas stream, at the moment of contact with a fiber, and after contact. Accurate values for all properties are needed, not only for predicting particle capture in actual service, but also to validate models for media geometries and computational procedures used in CFD. We present a survey of existing literature on the properties influencing nanoparticle dynamics and adhesion.

  18. Enhanced Vascularization in Hybrid PCL/Gelatin Fibrous Scaffolds with Sustained Release of VEGF

    National Research Council Canada - National Science Library

    Wang, Kai; Chen, Xuejiao; Pan, Yiwa; Cui, Yun; Zhou, Xin; Kong, Deling; Zhao, Qiang

    2015-01-01

    .... In this study, fibrous scaffolds that consist of PCL and gelatin fibers were fabricated. The gelatin fibers were further functionalized by heparin immobilization, which provides binding sites for VEGF and thus enables the sustained release of VEGF...

  19. Alternating magnetic field heat behaviors of PVDF fibrous mats filled with iron oxide nanoparticles

    Directory of Open Access Journals (Sweden)

    Jinu Kim

    2016-05-01

    Full Text Available To study the magnetic heat behaviors, iron oxide nanoparticles (IONPs and the polyvinylidene fluoride (PVDF fibrous mats filled with IONPs were prepared by using coprecipitaion method and the electrospinning technique. The synthesized IONPs exhibited a magnetization of about 72 emu/g with average diameter of about 10 nm. The magnetizations of PVDF fibrous mats filled with IONPs showed 2.6 emu/g, 5.5 emu/g and 9.9 emu/g for 5 wt.%, 10 wt.% and 20 wt.% IONPs concentration, respectively. The heat of the magnetic fibrous mats were measured under various alternating magnetic fields (90, 128, and 167 Oe, frequencies (190, 250 and 355 kHz. The maximum saturated temperature showed up to 62 °C for 20 wt.% IONPs filled in PVDF fibrous mat under 167 Oe and 355 kHz.

  20. Alternating magnetic field heat behaviors of PVDF fibrous mats filled with iron oxide nanoparticles

    Science.gov (United States)

    Kim, Jinu; Choi, Jung-Su; Yang, Heejae; Ko, Frank K.; Kim, Ki Hyeon

    2016-05-01

    To study the magnetic heat behaviors, iron oxide nanoparticles (IONPs) and the polyvinylidene fluoride (PVDF) fibrous mats filled with IONPs were prepared by using coprecipitaion method and the electrospinning technique. The synthesized IONPs exhibited a magnetization of about 72 emu/g with average diameter of about 10 nm. The magnetizations of PVDF fibrous mats filled with IONPs showed 2.6 emu/g, 5.5 emu/g and 9.9 emu/g for 5 wt.%, 10 wt.% and 20 wt.% IONPs concentration, respectively. The heat of the magnetic fibrous mats were measured under various alternating magnetic fields (90, 128, and 167 Oe), frequencies (190, 250 and 355 kHz). The maximum saturated temperature showed up to 62 °C for 20 wt.% IONPs filled in PVDF fibrous mat under 167 Oe and 355 kHz.

  1. Classical radiological aspects of fibrous dysplasia; Aspectos radiologicos classicos da displasia fibrosa nas radiografias do cranio

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Norma Selma Santos; Moraes e Silva, Denise; Lederman, Henrique M. [Escola Paulista de Medicina, Sao Paulo, SP (Brazil)

    1996-07-01

    The authors, after a review of the literature, show the features of fibrous dysplasia in the skull through conventional radiology, depicting the most common and classics aspects of this disease and its differential diagnosis. (author) 6 refs., 4 figs.

  2. Poliostotic fibrous dysplasia in the left maxilla sinus. Case of presentation

    National Research Council Canada - National Science Library

    Félix Dueñas Ros; Nery María Díaz Yanes; Dianarelys Villafuerte Delgado

    2007-01-01

    .... Paranasal x ray images didn’t permit to make the differential diagnosis between tumor or inflammatory lesions at the beginning, CT scan showed hiperdensy lesions like a tumor that suggest fibrous dysplasia...

  3. Vertical wicking tester for monitoring water transportation behavior in fibrous assembly

    Science.gov (United States)

    Singh, Pratibha; Chatterjee, Arobindo; Ghosh, Subrata

    2016-10-01

    An instrument based on the principle of change of resistance of fibrous assembly on wetting has been developed for precise monitoring of the water transportation behaviour in the fibrous assemblies. The conducting probes sense the change in resistance of a dry fibrous assembly on wetting. This change in resistance generates analog signals which trigger an amplifying circuit. This circuit produces an enlarged copy of the received signals which are further converted to digital signals by a Darlington pair and are encoded to measurable quantity with the help of a microcontroller. The data thus obtained are displayed on a suitable display device. Comparison between conventional strip test and experimental results obtained by the developed instrument shows its reliability. The developed instrument measures the initial rate of water transport with increased precision and hence could be used for detailed study of fluid flow in the fibrous structure.

  4. Study of application of hydrophobic fibrous sorbents for water purification from metal ions

    OpenAIRE

    Е. V. Petrova; Astashkina, А. P.; Filonenko, D. А.; Otmakhov, V. I.; Izaak, Т. I.; Volokitin, G. G.

    2007-01-01

    Sorption properties of hydrophobic fibrous sorbents on the basis of polypropylene and polyethylene terephthalate produced from thermoplastic polymer wastes to metal ion series in aqueous media has been studied. Based on the experimental data of extraction degree dependencies on fibre laying density, dispersity, presence of air in sorbent, volume of pass solution the mechanism of metal ion sorption from aqueous media with hydrophobic fibrous materials is suggested.

  5. Solitary fibrous tumor of the hard palate: a rare entity in oral cavity

    OpenAIRE

    Pinto, Antonione Santos Bezerra; Department of Oral Pathology – São Leopoldo Mandic Institute and Research Center – Campinas – SP – Brazil.; De Araújo, Vera Cavalcanti; Department of Oral Pathology – São Leopoldo Mandic Institute and Research Center – Campinas – SP – Brazil.; Santos, Fabrício Passador; Department of Oral Pathology – São Leopoldo Mandic Institute and Research Center – Campinas – SP – Brazil.; Filho, José Ferreira de Menezes; Antonio Carlos Institute of Tocantins – Araguaína – TO – Brazil.; Siqueira, Viviane; Department of Oral Pathology – São Leopoldo Mandic Institute and Research Center – Campinas – SP – Brazil.; Soares, Andresa Borges; Department of Oral Pathology – São Leopoldo Mandic Institute and Research Center – Campinas – SP – Brazil.

    2016-01-01

    A case of solitary fibrous tumor is reported. Solitary fibrous tumor is a rare neoplasia characterized by the proliferation of fusiform cells of mesenchymal origin accounting for at least 2% of all soft tissue tumors. In this present case, the initial diagnosis was salivary gland tumor because of the location in the hard palate. Histologically, the tumor was composed by conjunctive tissue with proliferation of oval and fusiform cells. The immunohistochemical analysis was positive for CD34 and...

  6. A fibrous hypercrosslinked sorbent prepared on PP-ST-DVB matrix via post-crosslinking reaction

    Institute of Scientific and Technical Information of China (English)

    Feng Liu; Si Guo Yuan; Xiao Li Wang; A.P. Polikarpov; A.A. Shunkevich

    2007-01-01

    A fibrous sorbent possessing abundant micropore structure was firstly prepared via post-crosslinking reaction on the PP-ST-DVB original fiber. Its micromorphology and sorptive properties were investigated, and the results. Demonstrated that the novel fibrous hypercrosslinked sorbent has narrow pore-size distribution, small average porous radius (1.90 nm), high specific surface area (362.31 m2/g), and fine sorptive properties for small organic molecules.

  7. Fibrous Pseudotumor of the Tunica Vaginalis Associated With Hydrocele and Testicular Atrophy

    Directory of Open Access Journals (Sweden)

    Pande Made Wisnu Tirtayasa

    2014-07-01

    Full Text Available Fibrous pseudotumors of the testicular tunics and paratesticular tissue are uncommon lesions. They typically arise as painless scrotal masses that may be associated with hydrocele or history of surgery, trauma, or infection. Although benign, these lesions often clinically indicate malignancy and usually remain undiagnosed preoperatively. Here, we report on a 59-year-old man with fibrous pseudotumor of the tunica vaginalis associated with hydrocele and testicular atrophy.

  8. Poliostotic fibrous dysplasia in the left maxilla sinus. Case of presentation.

    Directory of Open Access Journals (Sweden)

    Félix Dueñas Ros

    2007-04-01

    Full Text Available We present a clinic case of poliostotic fibrous dysplasia in the left maxilla sinus extended to Pterigopaltinar cavity and sphenoid sinus in a 26 year old woman who suffer from facial deformation. Paranasal x ray images didn’t permit to make the differential diagnosis between tumor or inflammatory lesions at the beginning, CT scan showed hiperdensy lesions like a tumor that suggest fibrous dysplasia. The final diagnosis was obtained by biopsy of the lesions.

  9. Cystic solitary fibrous tumor arising from the left occipital meninges: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Bae Geun; Hwang, Yoon Joon; Cha, Soon Joo; Hur, Gham; Kim, Yong Hoon; Kim, Su Young; Seo, Jung Wook; Lee, Ji Young; Kim, Han Seung [Ilsan Paik Hospital, Inje University, School of Medicine, Goyang (Korea, Republic of)

    2007-02-15

    Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm of a spindle-cell origin, and it usually involves the pleura. It's occurrence in various organs of the body has recently been described. Meningeal SFT is very rare. Radiologically, it is a strongly enhancing solid mass and is undistinguishable from fibrous meningioma and hemangiopericytoma. Yet we report here on a case of SFT with massive cystic degeneration that arose from the meninges of the left occipital region.

  10. BMP-2 immobilized PLGA/hydroxyapatite fibrous scaffold via polydopamine stimulates osteoblast growth.

    Science.gov (United States)

    Zhao, Xingyu; Han, Yu; Li, Jiawei; Cai, Bo; Gao, Hang; Feng, Wei; Li, Shuqiang; Liu, Jianguo; Li, Dongsong

    2017-09-01

    Combining biomaterials scaffolds with bone morphogenetic protein-2 (BMP-2) is currently used to promote the regeneration of bone tissue. However, the traditional strategies used to add BMP-2 into the polymer scaffolds directly suffer from limitations that can result in lower growth factor loading and damage the bioactivity of growth factors. In this study, we report the fabrication of poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) composite fibrous scaffolds via melt-spinning method to mimic native extracellular matrix (ECM). In order to effectively immobilize BMP-2 on PLGA/HA composite fibrous scaffolds, the surface of the scaffold was modified with polydopamine (PDA) (PDA-PLGA/HA). PDA was chosen as an adhesive polymeric bridge-layer between PLGA/HA fibrous scaffolds and BMP-2. Analysis of the scaffold using scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscope revealed that the PDA coating was attached to the scaffold surface. Moreover, analysis of the scaffold using water contact angle demonstrated an increased hydrophilicity via PDA modification. Furthermore, the PDA coating effectively immobilized BMP-2 on the PDA-PLGA/HA fibrous scaffold and a sustained release profile of BMP-2 was achieved in the BMP-2-immobilized PLGA/HA fibrous scaffold. In vitro experiments showed that BMP-2-immobilized PLGA/HA fibrous scaffold significantly promoted the attachment and proliferation of MC3T3-E1 cells. More importantly, the ALP activity, mRNA expression of osteosis-related genes and calcium deposition in MC3T3-E1 cells cultured on BMP-2-immobilized PLGA/HA fibrous scaffold were significantly increased. These results collectively demonstrate that the BMP-2-immobilized PLGA/HA fibrous scaffold is a promising candidate for bone regeneration. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. [Investigation of fibrous cultural materials by infrared spectroscopy].

    Science.gov (United States)

    Luo, Xi-yun; Du, Yi-ping; Shen, Mei-hua; Zhang, Wen-qing; Zhou, Xin-guang; Fang, Shu-ying; Zhang, Xuan

    2015-01-01

    Cultural fibrous material includes both important categories, i. e. textile and paper, consisting of precious cultural materials in museum, such as costume, painting, and manuscript. In recent years more and more connoisseur and conservator's concerns are, through nondestructive method, the authenticity and the ageing identification of these cultural relics especially made from fragile materials. In this research, we used attenuated total reflection infrared spectroscopy to identify five traditional textile fibers, alongside cotton, linen, wool, mulberry silk and tussah silk, and another five paper fibers alongside straw, wheat straw, long qisong, Chinese alpine rush and mulberry bar, which are commonly used for making Chinese traditional xuan paper. The research result showed that the animal fiber (wool, mulberry silk and tussah silk) and plant fiber (cotton and linen) were easier to be distinguished by comparing the peaks at 3 280 cm-1 belonging to NH stretching vibration and a serious peaks related to amide I to amide III. In the spectrum of wool, the peak at 1 076 cm-1 was assigned to the S-O stretching vibration absorption of cystine in wool structure and can be used to tell wool from silk. The spectrum of mulberry silk and tussah silk seems somewhat difficult to be identified, as well as the spectrum of cotton and linen. Five rural paper fibers all have obvious characteristic peaks at 3 330, 2 900 cm-1 which are related to OH and CH stretching vibration. In the fingerprint wavenumber range of 1 600 - 800 cm, the similar peaks also appeared at 1 370, 1 320 cm-1 and 1 162, 1 050 cm-1, both group peaks respectively are related to CH and CO vibration in the structure of cellulose and hemicellulose in paper fibers. Although there is more similarity of the infrared spectroscopy of these 5 paper fibers, some tiny difference in absorbance also can be found at 3 300 cm-1 and in the fingerprint range at 1 332, 1 203, and 1 050 cm-1 which are related to C-O-C vibration

  12. Fibrous osteodystrophy in two Northern Royal albatross chicks (Diomedea sanfordi).

    Science.gov (United States)

    Morgan, K J; Alley, M R; Gartrell, B D; Thompson, K G; Perriman, L

    2011-09-01

    In February 2004, two Northern Royal albatross chicks aged 20 and 25 days old were presented for necropsy. Both chicks had been hand-fed in situ at a breeding colony, from 2-3 days post-hatch. The hand-rearing diet consisted of boneless hoki fillets (Macraronus novaezelandiae), electrolytes, and sooty shearwater (Puffinus griseus) proventricular oil obtained as a by-product of cultural harvest. Routine necropsies on the affected chicks revealed many bones were soft and easily bent. Radiography and histopathology revealed decreased bone density, pathological fractures, and extensive remodelling suggestive of fibrous osteodystrophy. Nutritional secondary hyperparathyroidism, resulting from an imbalance in the dietary Ca:P ratio. The imbalance in the dietary Ca:P ratio was a result of feeding deboned and eviscerated fish. This investigation also highlighted potential health risks associated with the practice of feeding stored rancid proventricular oil, including the destruction of fat-soluble vitamins. It is therefore possible that oxidative degradation of vitamin D may have contributed to the development of nutritional secondary hyperparathyroidism. Subsequently, dietary recommendations for supplementary feeding of orphaned Northern Royal albatross chicks include the feeding of whole human-grade fish with an appropriate Ca:P ratio, and the exclusion of proventricular oil. These cases highlight the need for scientific input into wildlife conservation projects, as lack of appropriate nutritional advice resulted in the feeding of a nutritionally inadequate diet. Following the recommended changes in diet, no further cases of osteodystrophy have been diagnosed in hand-raised chicks in the albatross colony.

  13. Heat transfer in Rockwool modelling and method of measurement. Modelling radiative heat transfer in fibrous materials

    Energy Technology Data Exchange (ETDEWEB)

    Dyrboel, Susanne

    1998-05-01

    Fibrous materials are some of the most widely used materials for thermal insulation. In this project the focus of interest has been on fibrous materials for building application. Interest in improving the thermal properties of insulation materials is increasing as legislation is being tightened to reduce the overall energy consumption. A knowledge of the individual heat transfer mechanisms - whereby heat is transferred within a particular material is an essential tool to improve continuously the thermal properties of the material. Heat is transferred in fibrous materials by four different transfer mechanisms: conduction through air, conduction through fibres, thermal radiation and convection. In a particular temperature range the conduction through air can be regarded as a constant, and conduction through fibres is an insignificant part of the total heat transfer. Radiation, however, constitutes 25-40% of the total heat transfer in light fibrous materials. In Denmark and a number of other countries convection in fibrous materials is considered as non-existent when calculating heat transmission as well as when designing building structures. Two heat transfer mechanisms have been the focus of the current project: radiation heat transfer and convection. The radiation analysis serves to develop a model that can be used in further work to gain a wider knowledge of the way in which the morphology of the fibrous material, i.e. fibre diameter distribution, fibre orientation distribution etc., influences the radiation heat transfer under different conditions. The convection investigation serves to examine whether considering convection as non-existent is a fair assumption to use in present and future building structures. The assumption applied in practically is that convection makes a notable difference only in very thick insulation, at external temperatures below -20 deg. C, and at very low densities. For lager thickness dimensions the resulting heat transfer through the

  14. Compositional variation of fibrous callus and joint cartilage in different internal environments

    Institute of Scientific and Technical Information of China (English)

    SUN Xiao-tang; HU Yun-yu; ZHAO Li; L(U) Rong; WANG Jun; BAI Jian-ping

    2006-01-01

    Objective: To evaluate the compositional variation of fibrous callus in the fracture site and the joint cavity and joint cartilage after being transplanted in the muscle pouch.Methods: Thirty 2-month-old New Zealand white rabbits (weighing 1-1.5 kg) were randomly divided into two groups: a callus transplantation group (Group A, n =15) and a cartilage transplantation group ( Group B, n =15). In Group A, closed radius fracture was made and the autologous fibrous callus was transplanted in the right knee joint cavity at 12 days postoperatively. In Group B, the right knee joint cartilage of the animals was transplanted in the autologous back muscle pouches under anesthesia. Then all the animals were killed by overdose anesthetic 3 weeks after transplantation. And the transplanted fibrous callus,the healed bones in the fracture sites and the transplanted joint cartilage were obtained for assessment of compositional variation.Results: Pure fibrous composition was found in the callus at the fracture sites in Group A at 12 days postoperatively. And for 11 out of the 15 animals, the fibrous callus was transformed into cartilaginous tissues after 3 weeks of transplantation, but the fibrous callus was absent in the other 4 animals. The fibrous calluses at the original site and the fracture locus were differentiated into bony tissues. Bony tissue transformation was found in the transplanted joint cartilages in the muscle pouch of all the animals in Group B.Conclusions: The fracture sites or joint cavity may facilitate callus differentiation in different ways: the former is helpful for osteogenesis while the latter for the development and maintenance of cartilages, and the muscle pouch is inclined to induce the osteogenic phenotype for cartilages.

  15. Self-assembly studies of native and recombinant fibrous proteins

    Science.gov (United States)

    Wilson, Donna Lucille

    The structure of silk proteins consists of alternating amorphous (glycine-rich) and ordered crystalline regions (poly(alanine) and poly(glycine-alanine) repeats), where the organized regions are typically beta-sheet assemblies. In collagen, the basic helical repeat (glycine-proline-hydroxyproline and variants on this repeat) drives hierarchical assembly. Three polypeptide chains form left-handed poly-proline II-like helices, these three chains then self-assemble to form a right-handed triple helix. The focus of this thesis is on these proteins and defined variations thereof to reveal features of fibrous protein self-assembly. The amino acid sequences of native silk and collagen and their respective assembly environments have been systematically manipulated. Spider silk protein, based on the consensus sequence of Nephila clavipes dragline-silk, was genetically engineered to include methionines flanking the beta-sheet forming polyalanine regions. These methionines could be selectively oxidized and reduced, altering the bulkiness and charge of a methionine-based sulfoxide group to control beta-sheet formation by steric hindrance. A second version of the sterical trigger included a recognition site for Protein Kinase A allowing for the selective phosphorylation of a serine. Patterning a monolayer of precursor "director" molecules on length scales ranging from nanometer- to micrometer-length scales simplifies the interpretation of supramolecular assembly. Utilizing the atomic force microscopy (AFM)-based technique of dip-pen nanolithography, thiolated collagen and a collagen-like peptide were patterned at 30--50 nm line widths on evaporated gold surfaces. These are the largest molecules thus far positively printed on a surface at such small-length scales. The method preserved the triple helical structure and biological activity of collagen and even fostered the formation of characteristic higher-levels of structural organization. Nanopatterns were also achieved for

  16. Optical reflectance in fibrous tissues and skeletal muscles

    Science.gov (United States)

    Ranasinghesagara, Janaka C.

    We studied two biological tissues with optically anisotropic structures: high moisture soy protein extrudates and skeletal muscles. High moisture extrusion has been used to produce vegetable meat analogs that resemble real animal meat and have significant health benefits. Since visual and textural properties are key factors for consumer acceptance, assessing fiber formation in the extruded soy protein product is important for quality control purpose. A non-destructive method based on photon migration was developed to measure fiber formation in extruded soy proteins. The measured fiber formation index in intact samples showed good agreement with that obtained from image analysis on peeled samples. By implementing this new method in a fast laser scanning system, we have acquired two dimensional mappings of fiber formation and orientation in the entire sample in real time. In addition to fibrous structures, skeletal muscles have a unique periodic sarcomere structure which produces strong light diffractions. However, inconsistent experimental results have been reported in single fiber diffraction studies. By applying the three-dimensional coupled wave theory in a physical sarcomere model, we found that a variety of experimental observations can be explained if inhomogeneous muscle morphological profiles are considered. We also discovered that the sarcomere structure produced a unique optical reflectance pattern in whole muscle. None of the existing light propagation theories are able to describe this pattern. We developed a Monte Carlo model incorporating the sarcomere diffraction effect. The simulated results quantitatively resemble the unique patterns observed in experiments. We used a set of parameters to quantify the optical reflectance profiles produced by a point incident light in whole muscle. Two parameters, q and B, were obtained by numerically fitting the equi-intensity contours of the reflectance pattern. Two spatial gradients were calculated along the

  17. Preparation of poly(ethylene glycol/polylactide hybrid fibrous scaffolds for bone tissue engineering

    Directory of Open Access Journals (Sweden)

    Ni P

    2011-11-01

    Full Text Available PeiYan Ni, ShaoZhi Fu, Min Fan, Gang Guo, Shuai Shi, JinRong Peng, Feng Luo, ZhiYong QianState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People's Republic of ChinaAbstract: Polylactide (PLA electrospun fibers have been reported as a scaffold for bone tissue engineering application, however, the great hydrophobicity limits its broad application. In this study, the hybrid amphiphilic poly(ethylene glycol (PEG/hydrophobic PLA fibrous scaffolds exhibited improved morphology with regular and continuous fibers compared to corresponding blank PLA fiber mats. The prepared PEG/PLA fibrous scaffolds favored mesenchymal stem cell (MSC attachment and proliferation by providing an interconnected porous extracellular environment. Meanwhile, MSCs can penetrate into the fibrous scaffold through the interstitial pores and integrate well with the surrounding fibers, which is very important for favorable application in tissue engineering. More importantly, the electrospun hybrid PEG/PLA fibrous scaffolds can enhance MSCs to differentiate into bone-associated cells by comprehensively evaluating the representative markers of the osteogenic procedure with messenger ribonucleic acid quantitation and protein analysis. MSCs on the PEG/PLA fibrous scaffolds presented better differentiation potential with higher messenger ribonucleic acid expression of the earliest osteogenic marker Cbfa-1 and mid-stage osteogenic marker Col I. The significantly higher alkaline phosphatase activity of the PEG/PLA fibrous scaffolds indicated that these can enhance the differentiation of MSCs into osteoblast-like cells. Furthermore, the higher messenger ribonucleic acid level of the late osteogenic differentiation markers OCN (osteocalcin and OPN (osteopontin, accompanied by the positive Alizarin red S staining, showed better maturation of osteogenic induction on the PEG/PLA fibrous scaffolds at the

  18. PIV-based investigation of the skin friction of the flow over random fibrous media

    Science.gov (United States)

    Mirbod, Parisa; Gheisari, Reza

    2015-11-01

    Finite Reynolds number (Reflow over fibrous medium inside a rectangular duct was studied using a planar 2D PIV system. Three different fibrous materials with different porosities were used. Fibrous material lined the bottom wall of the duct along the length of the duct. The flow regime for all tests was laminar, and measurements were all done when the flow reached a steady state. Error and uncertainty sources in the experiments were also discussed. Shear rates were estimated at the surface of the fibrous media. As a conclusion to this study skin friction factor were calculated at the interface of all fibrous media at selected Reynolds number. Then using power function, curve fits with the Cf = a/Re form were found which could closely correlate skin friction and Reynolds number. To weaken the effect of near-wall errors in estimated shear rates and consequently skin friction, an average of shear rate estimation in a layer with thickness of 5 mm was calculated which was used to calculate an average skin friction. Correlations of average skin friction with average Reynolds number were also presented.

  19. Contrasting the morphology, anatomy and fungal colonization of new pioneer and fibrous roots.

    Science.gov (United States)

    Zadworny, Marcin; Eissenstat, David M

    2011-04-01

    Not all roots born as first-order branches are the same and this has important consequences for overall function. We hypothesized that, compared with fibrous roots, pioneer roots are built to live longer at the expense of absorptive capacity. We tested this hypothesis by investigating pioneer and fibrous roots in their first 14 d of life in the arbuscular mycorrhizal tree species: Acer negundo, Acer saccharum, Juglans nigra, Liriodendron tulipifera and Populus tremuloides. Root observations were made with root-access boxes that allowed roots to be sampled at known ages in field-grown trees. Compared to fibrous roots, pioneer roots had larger diameter, lower specific root length, greater average length and a lack of mycorrhizal or nonmycorrhizal fungal colonization. Pioneer roots < 14 d old had more layers of hypodermis with a lower percentage of putative passage cells and more protoxylem groups than similar age fibrous roots. Our results suggest that pioneer roots are constructed for defense against biotic and abiotic challenges, exploration of soil distal to the stem, high fibrous root branching and secondary development with high axial hydraulic conductivity at the expense of mycorrhizal colonization and high absorptive capacity for water and nutrients.

  20. IL-4 gene expression in adventitial layer (fibrous layer) of hepatic ovine and bovine hydatid cysts.

    Science.gov (United States)

    Dorosti, Zahra; Tolouei, Sepideh; Khanahmad, Hossein; Jafari, Rasool; Jafaee, Fereshteh; Sharafi, Seyedeh Marayam; Darani, Hossein Yousofi

    2016-09-01

    Cystic Echinococcosis is a parasitic disease with cosmopolitan distribution caused by the tape worm Echinococcus granulosus. Fibrous layer is developed around the cyst as a host immune response reaction. The aim of this study was to evaluate the rate of IL-4 gene expression in fibrous layer of bovine and ovine hepatic hydatid cysts using quantitative technique of Real-Time PCR. In this descriptive study the samples of hydatid cyst fibrous layer were taken from 6 bovine and 6 ovine hepatic hydatid cysts. Samples of normal liver tissue close to the cyst were also taken as controls. Total RNA from each sample was extracted and then converted to cDNA. Afterward, the rate of IL-4 gene expression for each sample was evaluated using real-time PCR technique. Data were analyzed by REST software (version 2.0.13, 2009). In sheep the rate of IL-4 gene expression in the fibrous layer of hepatic hydatid cysts was 1.98 times more than the rate of IL4 gene expression in control samples, but the difference was not significant (P = 0.561). In cattle the rate of IL-4 gene expression in the fibrous layer of hepatic hydatid cysts was 9.84 times more than that of control samples which was statistically significant (P layer of bovine hydatid cyst, it can be concluded that this interleukin may play an important role in host parasite relationship.

  1. Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face*

    Science.gov (United States)

    Henriques, Águida Cristina Gomes; Freitas, Roseana de Almeida; Pires, Bruno Cunha; Gurgel, Clarissa Araújo; dos Santos, Jean Nunes

    2016-01-01

    Background The morphological similarities between fibrous papules of the face and multiple sporadic oral fibromas were mentioned long ago and a relationship between them has been reported in the literature. Objective The aim of this study was to evaluate the participation of mast cells, elastin and collagen in a series of oral fibromas and fibrous papules of the face in order to better understand the possible role of these factors in fibrosis and the formation of these lesions. Methods Thirty cases of oral fibroma involving the buccal mucosa and 30 cases of fibrous papules of the face were selected. Tissue samples were submitted to picrosirius red staining and immunohistochemistry using anti-elastin and anti-tryptase antibodies. Results The percentage of tryptase-positive mast cells and expression of elastin were higher in cases of fibrous papules of the face (p < 0.05). In contrast, a higher intensity of collagen deposition was observed in oral fibromas. The results showed mast cell accumulation and higher elastin synthesis in fibrous papules of the face, and mast cell accumulation with higher collagen fiber synthesis in oral fibromas. Conclusion These findings support the hypothesis that mast cells influence the development and growth of these lesions through different mechanisms. PMID:27828630

  2. A dual-functional fibrous scaffold enhances P450 activity of cultured primary rat hepatocytes.

    Science.gov (United States)

    Chua, Kian-Ngiap; Tang, Yen-Ni; Quek, Chai-Hoon; Ramakrishna, Seeram; Leong, Kam W; Mao, Hai-Quan

    2007-09-01

    We have designed a novel dual-functional electrospun fibrous scaffold comprising two fiber mesh layers that were modified differently to induce two separate biological responses from hepatocytes. The first fiber layer was galactosylated on the surface to mediate hepatocyte attachment, while the second layer was loaded with 3-methylcholanthrene (3-Mc) to enhance cytochrome P450 activity of hepatocytes. Primary rat hepatocytes cultured on the galactosylated fibrous scaffolds loaded with different concentrations of 3-Mc were compared for their cell attachment efficiency, albumin secretion activity and cytochrome P450-dependent 7-ethoxycoumarin O-deethylase activity. This hybrid fibrous scaffold mediated hepatocyte attachment with slightly lower efficiency (76+/-2.3%) than a single-layer galactosylated fibrous scaffold (84+/-3.5%). More importantly, the cytochrome P450 activity of the hepatocytes cultured on the hybrid scaffold correlated well with the 3-Mc loading level. The results also showed that transfer of 3-Mc to hepatocytes through direct cell-fiber contact was the dominant transport route, with the induced cytochrome P450 activity being 1.9- to 4.8-fold higher than that of transfer of 3-Mc to hepatocytes via dissolution from fibers to medium. This study demonstrates the feasibility of creating multi-functional fibrous scaffolds that serve both as an adhesive substrate and as a delivery vehicle for bioactive molecules.

  3. Hypertrophied anal papillae and fibrous anal polyps, should they be removed during anal fissure surgery?

    Institute of Scientific and Technical Information of China (English)

    Pravin J. Gupta

    2004-01-01

    AIM: Hypertrophied anal papillae and fibrous anal polyps are not given due importance in the proctology practice.They are mostly ignored being considered as normal structures. The present study was aimed to demonstrate that hypertrophied anal papillae and fibrous anal polyps could cause symptoms to the patients and that they should be removed in treatment of patients with chronic fissure in anus.METHODS: Two groups of patients were studied. A hundred patients were studied in group A in which the associated fibrous polyp or papillae were removed by radio frequency surgical device after a lateral subcutaneous sphincterotomy for relieving the sphincter spasm. Another group of a hundred patients who also had papillae or fibrous polyps, were treated by lateral sphincterotomy alone. They were followed up for one year.RESULTS: Eighty-nine percent patients from group A expressed their satisfaction with the treatment in comparison to only 64% from group B who underwent sphincterotomy alone with the papillae or anal polyps left untreated. Group A patients showed a marked reduction with regard to pain and irritation during defecation (P= 0.0011),pricking or foreign body sensation in the anus (P = 0.0006)and pruritus or wetness around the anal verge (P = 0.0008).CONCLUSION: Hypertrophied anal papillae and fibrous anal polyps should be removed during treatment of chronic anal fissure. This would add to effectiveness and completeness of the procedure.

  4. The influence of fibrous bed bulk density on the bed properties

    Directory of Open Access Journals (Sweden)

    Šećerov-Sokolović Radmila M.

    2003-01-01

    Full Text Available The mean properties of seven different fibrous materials and the properties of their different bed bulk densities were investigated. The morphology of the surface, size and geometry were measured by optical microscopy. The bed porosity was measured by the weighing method. The experimental bed permeability, in a high range of bulk density, was calculated from the values of the sanitary water pressure drop at a constant temperature of 15°C, since the data followed Darcy's law. The Reynolds number for a fibrous bed was calculated using a relation from the literature. The Reynolds number was less than 1 for all ranges of fluid velocity. Three empirical relations for fibrous bed permeability were used and compared with the experimental data. It was determined that the empirical data depended on the fiber diameter and fraction of solid in the bed. The relative error linearly increased with increasing fiber diameter.

  5. Unilateral Bimaxillary Idiopathic Fibrous Gingival Hyperplasia with Alveolar Bone Loss- Report of a Rare Case

    Directory of Open Access Journals (Sweden)

    R S Sathawane

    2007-01-01

    Full Text Available Gingival enlargements are of many types and vary according to the etiologic factors and pathologic processes that produce them. Though there are many classifications of gingival enlargement, the most practical one is as follows: 1 Inflammatory gingival enlargement 2 Fibrous gingival hyperplasia 3 Combination of inflammatory and fibrous hyperplasia. Gingival hyperplasia is a heterogeneous group of disorder, which appears clinically as diffuse, firm, and massive enlargement of the gingiva covering most of the crown of the teeth. Idiopathic gingival enlargement is a rare condition of undetermined etiology, although some cases have definite hereditary basis. A case of unilateral idiopathic fibrous gingival hyperplasia on left side of both the jaws with severe bone resorption is presented.

  6. Solitary fibrous tumor of the male breast: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Sessa Fausto

    2008-02-01

    Full Text Available Abstract Extrapleural solitary fibrous tumors are very rare and occasionally they appear in extraserosal soft tissues or parenchymatous organs. In such cases the right preoperative diagnosis is often difficult and challenging, because both radiological and cytological examinations are not exhaustive. For these reasons, surgical excision is frequently the only way to reach the correct diagnosis and to achieve definitive treatment. A few cases of solitary fibrous tumors have been also described in the breast. Although rare, this lesion opens difficulties in preoperative diagnosis entering in differential diagnosis with other benign lesions as well as with breast cancer. In this article we describe a case of a solitary fibrous tumor of the breast in a 49-year-old man. Problems related to differential diagnosis and the possible pitfalls that can be encountered in the diagnostic iter of such rare tumor are discussed.

  7. Electrospinning polyvinylidene fluoride fibrous membranes containing anti-bacterial drugs used as wound dressing.

    Science.gov (United States)

    He, Ting; Wang, Jingnan; Huang, Peilin; Zeng, Baozhen; Li, Haihong; Cao, Qingyun; Zhang, Shiying; Luo, Zhuo; Deng, David Y B; Zhang, Hongwu; Zhou, Wuyi

    2015-06-01

    The aim of this study was to synthesis drug-loaded fibrous membrane scaffolds for potential applications as wound dressing. Polyvinylidene fluoride (PVDF) fibrous membranes were loaded with enrofloxacin (Enro) drugs by using an electrospinning process, and their mechanical strength, drug release profile and anti-bacterial properties were evaluated. Enro drug-loaded PVDF membranes exhibited good elasticity, flexibility and excellent mechanical strength. The electrospinning Enro/PVDF membranes showed a burst drug release in the initial 12h, followed by sustained release for the next 3 days, which was an essential property for antibiotic drugs applied for wound healing. The drug-loaded PVDF fibrous membranes displayed excellent anti-bacterial activity toward Escherichia coli and Staphylococcus aureus. The results suggest that electrospinning PVDF membrane scaffolds loaded with drugs can be used as wound dressing.

  8. Frontonasal and fibrous dysplasia in a patient with unilateral cleft lip and palate.

    Science.gov (United States)

    Weathers, William M; Wolfswinkel, Erik M; Albright, Steven B; Hollier, Larry H; Buchanan, Edward P

    2013-07-01

    Frontonasal dysplasia is a rare entity. It has characteristic physical deformities: hypertelorism, broad nasal root, median facial cleft of the upper lip or palate, clefting of the nasal alae, poorly formed nasal tip, cranium bifidum occultum, and a widow's peak hairline. Fibrous dysplasia is a benign bone tumor in which normal bone is replaced by fibrous, poorly formed osseus tissues. We present a patient with frontonasal dysplasia who desired correction of her hypertelorism. Incidentally, fibrous dysplasia was found in her left orbit complicating surgical correction. In addition, the patient has velopharyngeal insufficiency and a class III malocclusion. The interplay of all these craniofacial defects makes the sequencing and timing of surgery important in this unique patient.

  9. Fibrous dysplasia: rapid malignant transformation into osteogenic sarcoma - A rare occurance

    Directory of Open Access Journals (Sweden)

    S Gon

    2012-09-01

    Full Text Available Malignant transformation of fibrous dysplasia is rare, occurring in less than 1% of cases with a mean lag period of 13.5 years. We report a case of Osteogenic Sarcoma with chondroid differentiation in a pre-existing Fibrous Dysplasia occurring within one year of surgical resection and without any history of exposure to radiation. To the best of our knowledge and extensive search of literature, malignant transformation of Fibrous Dysplasia in such a short period of time, and without history of radiation exposure has never been reported from India.Journal of Pathology of Nepal (2012 Vol. 2, 335-337DOI: http://dx.doi.org/10.3126/jpn.v2i4.6891

  10. A structure-based extracellular matrix expansion mechanism of fibrous tissue growth.

    Science.gov (United States)

    Kalson, Nicholas S; Lu, Yinhui; Taylor, Susan H; Starborg, Tobias; Holmes, David F; Kadler, Karl E

    2015-05-20

    Embryonic growth occurs predominately by an increase in cell number; little is known about growth mechanisms later in development when fibrous tissues account for the bulk of adult vertebrate mass. We present a model for fibrous tissue growth based on 3D-electron microscopy of mouse tendon. We show that the number of collagen fibrils increases during embryonic development and then remains constant during postnatal growth. Embryonic growth was explained predominately by increases in fibril number and length. Postnatal growth arose predominately from increases in fibril length and diameter. A helical crimp structure was established in embryogenesis, and persisted postnatally. The data support a model where the shape and size of tendon is determined by the number and position of embryonic fibroblasts. The collagen fibrils that these cells synthesise provide a template for postnatal growth by structure-based matrix expansion. The model has important implications for growth of other fibrous tissues and fibrosis.

  11. Solitary fibrous tumor of the sellar region treated with adjuvant radiation therapy

    Science.gov (United States)

    Sahai, Puja; Singh, Geetika; Mondal, Dodul; Suri, Vaishali; Julka, Pramod Kumar

    2016-01-01

    The solitary fibrous tumor of central nervous system is rare. Herein, a case of solitary fibrous tumor arising from sellar region is described. A 60-year-old man underwent subtotal excision of the tumor because of extensive infiltration of optical and vascular structures. In view of the presence of residual tumor, he was treated with adjuvant radiation therapy. After a follow-up period of 1 year, there was no progression of the lesion evident on magnetic resonance imaging of the brain. Solitary fibrous tumor should be considered as one of the differential diagnosis of a mass lesion arising in sellar region. Immunohistochemistry with CD34 is valuable for discerning the diagnosis. Complete surgery should be the goal of treatment and adjuvant radiation therapy may be considered for residual or recurrent disease. PMID:27695561

  12. A Novel Method to Decrease Micro-residual Stresses of Fibrous Composites by Adding Carbon Nanotube

    Directory of Open Access Journals (Sweden)

    M. M. Shokrieh

    2013-12-01

    Full Text Available In this research, a novel method to decrease micro-residual stresses of fibrous composites by adding carbon nanotubes (CNTs is proposed in detail. The negative coefficient of thermal expansion and the high young’s modulus of CNTs can be utilized to counterbalance the process induced residual stresses in composites. To this end, first, the effects of adding CNTs to the matrix of fibrous composites in reducing the coefficient of thermal expansion (CTE and increasing of young’s modulus of matrix are studied theoretically. Then, a three phase micromechanical model (the energy method is used to model the effect of CNT in reducing the residual stresses of fibrous composites. The results show that by addition of CNTs, enhancements in properties of matrix are obtained and lead to decrease in micro-residual stresses of matrix and fiber up to 72%.

  13. A New Device for Characterisation of the Drainage Kinetics of Fibrous Suspensions Under Gravity

    Directory of Open Access Journals (Sweden)

    Przybysz Piotr

    2014-12-01

    Full Text Available Gravity dewatering of fibrous suspension is one of basic technological operations in paper production process. Although there are numerous methods to determine dewatering of such suspensions, none of them can measure undisturbed flow of removed water. In the paper the idea and design of a new apparatus for the determination of drainage rate of fibrous suspensions is presented. The apparatus differs from other known devices by minimisation of filtrate flow resistance in the outlet part of the equipment. In the second part of the paper measurements of the drainage rate have been presented. The flow resistance of the fluid through the bottom wire screen in the device was determined. The calculated flow resistance will be used in the developed model of dynamic drainage of fibrous suspensions, which will be discussed in our following paper (Przybysz et al., 2014.

  14. Anti-inflammatory, anti-bacterial, and cytotoxic activity of fibrous clays.

    Science.gov (United States)

    Cervini-Silva, Javiera; Nieto-Camacho, Antonio-; Ramírez-Apan, María Teresa; Gómez-Vidales, Virginia; Palacios, Eduardo; Montoya, Ascención; Ronquillo de Jesús, Elba

    2015-05-01

    Produced worldwide at 1.2m tons per year, fibrous clays are used in the production of pet litter, animal feed stuff to roof parcels, construction and rheological additives, and other applications needing to replace long-fiber length asbestos. To the authors' knowledge, however, information on the beneficial effects of fibrous clays on health remains scarce. This paper reports on the anti-inflammatory, anti-bacterial, and cytotoxic activity by sepiolite (Vallecas, Spain) and palygorskite (Torrejon El Rubio, Spain). The anti-inflammatory activity was determined using the 12-O-tetradecanoylphorbol-13-acetate (TPA) and myeloperoxidase (MPO) methods. Histological cuts were obtained for quantifying leukocytes found in the epidermis. Palygorkite and sepiolite caused edema inhibition and migration of neutrophils ca. 68.64 and 45.54%, and 80 and 65%, respectively. Fibrous clays yielded high rates of infiltration, explained by cleavage of polysomes and exposure of silanol groups. Also, fibrous clays showed high inhibition of myeloperoxidase contents shortly after exposure, but decreased sharply afterwards. In contrast, tubular clays caused an increasing inhibition of myeloperoxidase with time. Thus, clay structure restricted the kinetics and mechanism of myeloperoxidase inhibition. Fibrous clays were screened in vitro against human cancer cell lines. Cytotoxicity was determined using the protein-binding dye sulforhodamine B (SRB). Exposing cancer human cells to sepiolite or palygorskite showed growth inhibition varying with cell line. This study shows that fibrous clays served as an effective anti-inflammatory, limited by chemical transfer and cellular-level signals responding exclusively to an early exposure to clay, and cell viability decreasing significantly only after exposure to high concentrations of sepiolite.

  15. Electrospun PVdF-based fibrous polymer electrolytes for lithium ion polymer batteries

    Energy Technology Data Exchange (ETDEWEB)

    Jeong Rae Kim [Hanyang University, Seoul (France). Applied Chemical Engineering Division; Korea Institute of Science and Technology, Seoul (Korea). Polymer Hybrid Research Center; Sung Won Choi [Yonsei University, Seoul (Korea). Department of Chemistry; Seong Mu Jo; Wha Seop Lee [Korea Institute of Science and Technology, Seoul (Korea). Polymer Hybrid Research Center; Byung Chul Kim [Hanyang University, Seoul (France). Applied Chemical Engineering Division

    2004-11-15

    This paper discusses the preparation of microporous fibrous membranes from PVdF solutions with different polymer contents, using the electrospinning technique. Electrospun PVdF-based fibrous membranes with average fiber diameters (AFD's) of 0.45-1.38 {mu}m have an apparent porosity and a mean pore size (MPS) of 80-89% and 1.1-4.3 {mu}m, respectively. They exhibited a high uptake of the electrolyte solution (320-350%) and a high ionic conductivity of above 1 x 10{sup -3} s/cm at room temperature. Their ionic conductivity increased with the decrease in the AFD of the fibrous membrane due to its high electrolyte uptake. The interaction between the electrolyte molecules and the PVdF with a high crystalline content may have had a minor effect on the lithium ion transfer in the fibrous polymer electrolyte, unlike in a nanoporous gel polymer electrolyte. The fibrous polymer electrolyte that contained a 1 M LiPF{sub 6}-EC/DMC/DEC (1/1/1 by weight) solution showed a high electrochemical stability of above 5.0 V, which increased with the decrease in the AFD. The interfacial resistance (R{sub i}) between the polymer electrolyte and the lithium electrode slightly increased with the storage time, compared with the higher increase in the interfacial resistance of other gel polymer electrolytes. The prototype cell (MCMB/PVdF-based fibrous electrolyte/LiCoO{sub 2}) showed a very stable charge-discharge behavior with a slight capacity loss under constant current and voltage conditions at the C/2-rate of 20 and 60 {sup o}C. (author)

  16. Electrospun PVdF-based fibrous polymer electrolytes for lithium ion polymer batteries

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeong Rae [Applied Chemical Engineering Division, Hanyang University, 17, Haengdang-dong, Seongdong-Ku, Seoul 133-791 (Korea, Republic of); Polymer Hybrid Research Center, Korea Institute of Science and Technology, 39-1, Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea, Republic of); Choi, Sung Won [Department of Chemistry, Yonsei University, 134, Sinchon-dong, Seodaemun-gu, Seoul 120-749 (Korea, Republic of); Polymer Hybrid Research Center, Korea Institute of Science and Technology, 39-1, Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea, Republic of); Jo, Seong Mu [Polymer Hybrid Research Center, Korea Institute of Science and Technology, 39-1, Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea, Republic of)]. E-mail: smjo@kist.re.kr; Lee, Wha Seop [Polymer Hybrid Research Center, Korea Institute of Science and Technology, 39-1, Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea, Republic of); Kim, Byung Chul [Applied Chemical Engineering Division, Hanyang University, 17, Haengdang-dong, Seongdong-Ku, Seoul 133-791 (Korea, Republic of)

    2004-11-15

    This paper discusses the preparation of microporous fibrous membranes from PVdF solutions with different polymer contents, using the electrospinning technique. Electrospun PVdF-based fibrous membranes with average fiber diameters (AFD's) of 0.45-1.38 {mu}m have an apparent porosity and a mean pore size (MPS) of 80-89% and 1.1-4.3 {mu}m, respectively. They exhibited a high uptake of the electrolyte solution (320-350%) and a high ionic conductivity of above 1 x 10{sup -3} s/cm at room temperature. Their ionic conductivity increased with the decrease in the AFD of the fibrous membrane due to its high electrolyte uptake. The interaction between the electrolyte molecules and the PVdF with a high crystalline content may have had a minor effect on the lithium ion transfer in the fibrous polymer electrolyte, unlike in a nanoporous gel polymer electrolyte. The fibrous polymer electrolyte that contained a 1 M LiPF{sub 6}-EC/DMC/DEC (1/1/1 by weight) solution showed a high electrochemical stability of above 5.0 V, which increased with the decrease in the AFD The interfacial resistance (R{sub i}) between the polymer electrolyte and the lithium electrode slightly increased with the storage time, compared with the higher increase in the interfacial resistance of other gel polymer electrolytes. The prototype cell (MCMB/PVdF-based fibrous electrolyte/LiCoO{sub 2}) showed a very stable charge-discharge behavior with a slight capacity loss under constant current and voltage conditions at the C/2-rate of 20 and 60 deg. C.

  17. Cystic fibrous osteodystrophy of the jaw in two pet kinkajous (Potos flavus).

    Science.gov (United States)

    Garma-Aviña, A; Torres-Montoya, J

    1998-11-07

    Two kinkajous (Potos flavus), which were separately owned as pets and fed an inappropriate diet consisting almost exclusively of succulent fruits developed cystic fibrous osteodystrophy of the jaw. In both cases there was a prominent enlargement of the chin and lower jaw, decalcification of facial bones, softening of the gingiva, and severe malocclusion, but no other relevant changes. Clinical, radiographic and histological findings were consistent with cystic fibrous osteodystrophy. The findings suggest that kinkajous with this condition are particularly prone to developing a bulbous enlargement of the chin as the main clinical sign, and that this change is histologically similar to the cystic form of the disease observed in man and monkeys.

  18. Exploiting BSA to Inhibit the Fibrous Aggregation of Magnetic Nanoparticles under an Alternating Magnetic Field

    Directory of Open Access Journals (Sweden)

    Ning Gu

    2013-03-01

    Full Text Available The alternating magnetic field was discovered to be capable of inducing the fibrous aggregation of magnetic nanoparticles. However, this anisotropic aggregation may be unfavorable for practical applications. Here, we reported that the adsorption of BSA (bovine serum albumin on the surfaces of magnetic nanoparticles can effectively make the fibrous aggregation of γ-Fe2O3 nanoparticles turn into a more isotropic aggregation in the presence of the alternating magnetic field. Also, the heating curves with and without BSA adsorption under different pH conditions were measured to show the influence of the colloidal aggregation states on the collective calorific behavior of magnetic nanoparticles.

  19. Cushing syndrome, sexual precocity, and polyostotic fibrous dysplasia (Albright syndrome) in infancy.

    Science.gov (United States)

    Danon, M; Robboy, S J; Kim, S; Scully, R; Crawford, J D

    1975-12-01

    The sexual precocity of polyostotic fibrous dysplasia is occasionally accompanied by other endocrine disorders, but in only two previous instances has Cushing syndrome been reported. The history of a 6-month-old girl is presented, in whom this syndrome was complicated by congenital Cushings syndrome. Although endocrinopathies of polyostotic fibrous dysplasia have usually been ascribed to a central (hypothalamic) origin, the findings in this patient suggest autonomous hyperfunction of the peripheral endocrine glands, with the Cushing syndrome caused by hyperplastic nodules in the adrenal glands and the precocity by luteinized follicular cysts of the ovary.

  20. Malignant Solitary Fibrous Tumor of the Kidney: Report of the First Case Managed with Interferon

    Directory of Open Access Journals (Sweden)

    Javier Cuello

    2013-01-01

    Full Text Available Solitary fibrous tumors of the kidney are extremely rare tumors with unpredictable behavior. We describe a case of a patient with a solitary fibrous tumor of kidney with malignant findings with distant metastasis and nephrectomy managed with subcutaneous interferon achieving 23 months of progression-free survival. To date there is no prospective evaluation of any specific modality of treatment, but the surgical management and long-term followup are the only ones so far recommended strategies in the management of these patients. Studies are awaited with more patients to evaluate the different strategies of systemic therapy reported so far to allow adding survival benefit.

  1. Malignant solitary fibrous tumor of the kidney: report of the first case managed with interferon.

    Science.gov (United States)

    Cuello, Javier; Brugés, Ricardo

    2013-01-01

    Solitary fibrous tumors of the kidney are extremely rare tumors with unpredictable behavior. We describe a case of a patient with a solitary fibrous tumor of kidney with malignant findings with distant metastasis and nephrectomy managed with subcutaneous interferon achieving 23 months of progression-free survival. To date there is no prospective evaluation of any specific modality of treatment, but the surgical management and long-term followup are the only ones so far recommended strategies in the management of these patients. Studies are awaited with more patients to evaluate the different strategies of systemic therapy reported so far to allow adding survival benefit.

  2. Solitary fibrous tumor of the larynx: report of two new cases

    Directory of Open Access Journals (Sweden)

    Fábio Muradás Girardi

    2014-06-01

    Full Text Available Solitary fibrous tumor is a rare neoplasm. Few cases have been described in the head and neck area, and less than 11 were located in the larynx. We described two new cases of solitary fibrous tumor of the larynx. A man, 64-year-old, and a woman, 77-year-old, both with submucosal and nodular supraglottic lesions, were submitted to surgical treatment and both showed CD-34 and bcl-2 immunoreactivity and S-100 and smooth-muscle actin negativity. After 24 and 22 months of postoperative follow-up, respectively, they did not show signs of active disease.

  3. Massive fibrous epulis-a case report of a 10-year-old lesion

    Institute of Scientific and Technical Information of China (English)

    Gabriel MFonseca; Ricardo MFonseca; Mario Cantn

    2014-01-01

    The fibrous epulis, a common tumor-like lesion of the gingiva, appears in the interdental papilla as a result of local irritation. Lesions are asymptomatic and have a variable growth rate. A 75-year-old woman was referred for the evaluation of a large painless gingival mass. It had started 10 years back and has been increasing in size the last year. No bone involvement was noted. The tumor was totally removed by excision with surgical scalpel under local anesthesia without teeth extraction. The microscopic findings were suggestive of a fibrous epulis. Differential diagnosis, clinical considerations and factors to prevent recurrence are discussed.

  4. Monostostic fibrous dysplasia with nonspecific cystic degeneration: A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Afreen Nadaf

    2013-01-01

    Full Text Available Fibrous dysplasia (FD has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that FD is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor. Here we report a case of bilateral monostotic FD in a middle-aged female showing a classic histological picture, but radiologically presenting as a mixed radiolucent radiopaque lesion showing nonspecific cystic degeneration.

  5. Nanoscale Piezoelectric Properties of Self-Assembled Fmoc-FF Peptide Fibrous Networks.

    Science.gov (United States)

    Ryan, Kate; Beirne, Jason; Redmond, Gareth; Kilpatrick, Jason I; Guyonnet, Jill; Buchete, Nicolae-Viorel; Kholkin, Andrei L; Rodriguez, Brian J

    2015-06-17

    Fibrous peptide networks, such as the structural framework of self-assembled fluorenylmethyloxycarbonyl diphenylalanine (Fmoc-FF) nanofibrils, have mechanical properties that could successfully mimic natural tissues, making them promising materials for tissue engineering scaffolds. These nanomaterials have been determined to exhibit shear piezoelectricity using piezoresponse force microscopy, as previously reported for FF nanotubes. Structural analyses of Fmoc-FF nanofibrils suggest that the observed piezoelectric response may result from the noncentrosymmetric nature of an underlying β-sheet topology. The observed piezoelectricity of Fmoc-FF fibrous networks is advantageous for a range of biomedical applications where electrical or mechanical stimuli are required.

  6. Application of Transistors in Textiles: Monitoring Water Transportation Behaviour in Fibrous Assemblies

    Science.gov (United States)

    Chatterjee, Arobindo; Singh, Pratibha; Ghosh, Subrata

    2016-11-01

    Simple semiconductor device has been used for amplifying the analog signals, obtained with the change in electrical resistance in fibrous assembly and converting these amplified copies of signals to digital signals. This paper deals with the application of transistors as amplifier, as well as switch. Different circuit configurations using transistors have been tried for sensing and reciprocating the real time data on suitable display device. It is found that transistors configured as common-emitter amplifiers can precisely sense the liquid at the surface of fibrous assembly at different levels with respect to time.

  7. Endemic pleural disease associated with exposure to mixed fibrous dust in Turkey

    Energy Technology Data Exchange (ETDEWEB)

    Rohl, A.N.; Langer, A.M.; Moncure, G.; Selikoff, I.J.; Fischbein, A.

    1982-04-30

    Pleural mesothelioma, lung cancer, pleural calcification and fibrosis, and interstitial parenchymal fibrosis have been observed among inhabitants of several villages in south-central Turkey. Earlier reports have stated that environmental and lung tissue samples from this area contained the fibrous zeolite mineral erionite, and this mineral has generally been assumed to be the agent responsible for these endemic pathological conditions in the absence of asbestos outcroppings and usage. Several different kinds of asbestos minerals in addition to erionite have now been found in environmental samples taken from the villages where these diseases occur. The lung tissues of mesothelioma patients from these villages contain both fibrous zeolites and asbestos minerals.

  8. Nitridated fibrous silica (KCC-1) as a sustainable solid base nanocatalyst

    KAUST Repository

    Bouhrara, Mohamed

    2013-09-03

    We observed that support morphology has dramatic effects on the performance of nitridated silica as a base. By simply replacing conventional silica supports (such as SBA-15 and MCM-41) with fibrous nanosilica (KCC-1), we observed multifold enhancement in the catalytic activity of the nitridated solid base for Knoevenagel condensations and transesterification reactions. This enhancement of the activity can be explained by amine accessibility, which is excellent in KCC-1 due to its open and flexible fibrous structure, that facilitates penetration and interaction with basic amine sites. © 2013 American Chemical Society.

  9. Invasive fibrous thyroiditis (Riedel's struma): a manifestation of multifocal fibrosclerosis? A case report with review of the literature.

    NARCIS (Netherlands)

    Lange, W E de; Freling, N J; Molenaar, W M; Doorenbos, H

    1989-01-01

    A patient is described with Riedel's thyroiditis and invasive fibrous growth in parathyroid, lacrimal glands, and retroperitoneally. It is proposed that Riedel's thyroiditis is not a disease in its own right but a manifestation of a generalized disease of fibrous tissues.

  10. Antibacterial and anti-adhesion effects of the silver nanoparticles-loaded poly(L-lactide) fibrous membrane

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Shen [Department of Orthopaedics, Shanghai Sixth People' s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233 (China); Zhao, Jingwen [Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215007 (China); School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030 (China); Ruan, Hongjiang; Wang, Wei [Department of Orthopaedics, Shanghai Sixth People' s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233 (China); Wu, Tianyi [Department of Orthopaedic Surgery, 2nd Affiliated hospital of Nanjing Medical University, Nanjing Medical University, 121 Jiang Jia Yuan, Nanjing 210011 (China); Cui, Wenguo, E-mail: wgcui80@hotmail.com [Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215007 (China); School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030 (China); Fan, Cunyi, E-mail: fancunyi888@hotmail.com [Department of Orthopaedics, Shanghai Sixth People' s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233 (China)

    2013-04-01

    The complications of tendon injury are frequently compromised by peritendinous adhesions and tendon sheath infection. Physical barriers for anti-adhesion may increase the incidence of postoperative infection. This study was designed to evaluate the potential of silver nanoparticles (AgNPs)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes to prevent adhesion formation and infection. Results of an in vitro drug release study showed that a burst release was followed by sustained release from electrospun fibrous membranes with a high initial silver content. Fewer fibroblasts adhered to and proliferated on the AgNP-loaded PLLA electrospun fibrous membranes compared with pure PLLA electrospun fibrous membrane. In the antibacterial test, the AgNP-loaded PLLA electrospun fibrous membranes can prevent the adhesion of Gram-positive Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa. Taken together, these results demonstrate that AgNP-loaded PLLA electrospun fibrous membranes have the convenient practical medical potential of reduction of infection and adhesion formation after tendon injury. - Highlights: ► Silver nanoparticles are directly electrospun into PLLA fibrous membrane. ► Long-lasting release of Ag + ions is achieved. ► Cytotoxicity of silver ions benefits the anti-proliferation of physical barriers. ► Broad anti-microbial effect of drug-loaded fibrous membrane is revealed. ► Antibacterial and anti-adhesion effects of the physical barriers are combined.

  11. Design of multi-layered porous fibrous metals for optimal sound absorption in the low frequency range

    Directory of Open Access Journals (Sweden)

    Wenjiong Chen

    2016-01-01

    Full Text Available We present a design method for calculating and optimizing sound absorption coefficient of multi-layered porous fibrous metals (PFM in the low frequency range. PFM is simplified as an equivalent idealized sheet with all metallic fibers aligned in one direction and distributed in periodic hexagonal patterns. We use a phenomenological model in the literature to investigate the effects of pore geometrical parameters (fiber diameter and gap on sound absorption performance. The sound absorption coefficient of multi-layered PFMs is calculated using impedance translation theorem. To demonstrate the validity of the present model, we compare the predicted results with the experimental data. With the average sound absorption (low frequency range as the objective function and the fiber gaps as the design variables, an optimization method for multi-layered fibrous metals is proposed. A new fibrous layout with given porosity of multi-layered fibrous metals is suggested to achieve optimal low frequency sound absorption. The sound absorption coefficient of the optimal multi-layered fibrous metal is higher than the single-layered fibrous metal, and a significant effect of the fibrous material on sound absorption is found due to the surface porosity of the multi-layered fibrous.

  12. Fibrous dysplasia associated with primary hyperparathyroidism absent of McCune-albright syndrome: Tc-99m MDP findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong Jang; Seok, Ju Won; Kim, In Ju; Kim, Yong Ki; Kim, Dong Soo [Pusan National University College of Medicine, Pusan (Korea, Republic of)

    2003-04-01

    Fibrous dysplasia is a chronic disorder of the skeleton that causes expansion of one or more bones due to abnormal development of the fibrous, or connective tissue within the bone. The abnormality will cause uneven growth, brittleness and deformity in affected bones. Some patients have only one bone affected, whereas other patients have numerous bones affected. While any bone can be affected by fibrous dysplasia, the most common sites of the disease are the femur, tibia, ribs, skull, facial bones, humerus, and pelvis. In conclusion, Tc-99m MDP bone scan as well as Tc-99m MIBI scan may be useful for the detection of fibrous dysplasia. Also, factors responsible for the uptake of MIBI by fibrous dysplasia will need to be studied further.

  13. Identification of autotoxic compounds in fibrous roots of Rehmannia (Rehmannia glutinosa Libosch..

    Directory of Open Access Journals (Sweden)

    Zhen-Fang Li

    Full Text Available Rehmannia is a medicinal plant in China. Autotoxicity has been reported to be one of the major problems hindering the consecutive monoculture of Rehmannia. However, potential autotoxins produced by the fibrous roots are less known. In this study, the autotoxicity of these fibrous roots was investigated. Four groups of autotoxic compounds from the aqueous extracts of the fibrous roots were isolated and characterized. The ethyl acetate extracts of these water-soluble compounds were further analyzed and separated into five fractions. Among them, the most autotoxic fraction (Fr 3 was subjected to GC/MS analysis, resulting in 32 identified compounds. Based on literature, nine compounds were selected for testing their autotoxic effects on radicle growth. Seven out of the nine compounds were phenolic, which significantly reduced radicle growth in a concentration-dependent manner. The other two were aliphatic compounds that showed a moderate inhibition effect at three concentrations. Concentration of these compounds in soil samples was determined by HPLC. Furthermore, the autotoxic compounds were also found in the top soil of the commercially cultivated Rehmannia fields. It appears that a close link exists between the autotoxic effects on the seedlings and the compounds extracted from fibrous roots of Rehmannia.

  14. Shear-induced fibrous structure formation from a pectin/SPI blend

    NARCIS (Netherlands)

    Dekkers, Birgit L.; Nikiforidis, Costas; Goot, van der Atze Jan

    2016-01-01

    Well-defined shear flow can be applied to create fibrous, anisotropic samples from biopolymers when present at sufficiently high dry matter contents. Anisotropic biopolymer structures are of high interest especially when made from plant-based polymer blends due to novel food applications, like me

  15. Fibrous dysplasia of the rib presenting as a huge chest wall tumor: report of a case.

    Science.gov (United States)

    Chang, B S; Lee, S C; Harn, H J

    1994-07-01

    Fibrous dysplasia of the rib is not uncommon, but is rarely demonstrated as a huge chest wall mass with severe clinical symptoms. A 59-year-old patient, presenting with a huge, rapidly expanding chest wall tumor compressing the lung, liver and heart accompanied by chest pain and dyspnea, is reported. The tumor was success-fully excised by local radical resection.

  16. A novel apparatus for countercurrent sorption separation processes using fibrous sorbents

    NARCIS (Netherlands)

    Diederen, A.M.; Zee, G. van; Veenman, A.W.; Graauw, J. de

    1998-01-01

    This paper discusses a technical feasibility study on continuous countercurrent sorption equipment using mechanically transported fibrous sorbent materials such as fiber beds and open-cell foam. A pilot unit was developed and tested and the apparatus performed adequately. Under the conditions applie

  17. Meningeal solitary fibrous tumor: report of a case and literature review.

    Science.gov (United States)

    Deniz, Kemal; Kontas, Olgun; Tucer, Bulent; Kurtsoy, Ali

    2005-01-01

    Solitary fibrous tumor is a rare neoplasm that most often involves the pleura. The increasing numbers of this neoplasm have also been reported to date in extrapleural sites. We report a case of a twenty-four-year-old female with right frontal mass. Histologically, the tumor composed of spindle cell proliferation. Tumor cells were found to be positive for CD34 and CD117 with immunohistochemical studies. Ten months follow-up was uneventful. Seventy seven cases of meningeal solitary fibrous tumor from the literature are analysed and pathological, immunohistochemical and clinical features are discussed. Solitary fibrous tumor has a slight female predominance, with a male to female ratio of 1:1.5. Age distribution is similar to meningioma ranging from 7-81 years. Approximately 23% of cases originate in the spine which is the most common meningeal location. Histopathologic examination shows uniform spindle cell proliferation with various amount of collagen. CD34-positivity usually allows discrimination from schwannomas, meningiomas and hemangiopericytomas. A differential diagnosis is important because most of the solitary fibrous tumors usually behave in a benign fashion. In this study, we also showed CD117 (Kit) expression in a case of meningeal SFT. CD117-positivity can be a good strategy for treatment in malignant and recurrent cases. Further investigations are necessary for therapeutic implication of CD117-positivity in SFT.

  18. Three dimensional web-like fibrous CuInS{sub 2} film

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Hyun [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of); Kim, Min-woo [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of); Green School, Korea University, Seoul, 136-713 (Korea, Republic of); Kim, Hayong [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of); Al-Deyab, Salem S. [Petrochemicals Research Chair, Dept. of Chem., King Saud University, Riyadh 11451 (Saudi Arabia); James, Scott C. [Depts of Geology and Mechanical Engineering, Baylor University, Waco TX 76798-2534 (United States); Ahn, SeJin, E-mail: swisstel@kier.re.kr [Photovoltaic Laboratory, Korea Institute of Energy Research, 71-2 Jangdong, YuseongGu, DaeJeon 305-543 (Korea, Republic of); Yoon, Sam S., E-mail: skyoon@korea.ac.kr [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of)

    2015-10-01

    Graphical abstract: - Highlights: • Electrospun nanofibers were used to construct a 3D CuInS{sub 2} solar cell with enhanced surface area. • SEM images showed the 3D web-like, fibrous structure of the film. • The surface area had nearly doubled after incorporating the 3D nanostructure. - Abstract: To ensure effective collection of photo-generated minority electrons in a CuInS{sub 2} thin film solar cell, a three-dimensional nanostructure was constructed by electrospinning a copper-indium solution precursor onto a molybdenum substrate. The electrospun nanofibers adhered onto the underlying layers before undergoing sulfurization at 500 °C to produce a three-dimensional web-like fibrous CuInS{sub 2} film. This fibrous film was characterized by scanning electron microscopy, X-ray diffraction, and Auger electron spectroscopy, thereby characterizing the 3D fibrous nanostructure of the CuInS{sub 2} film. This 3D structure could lead to next-generation solar cells optimized for maximal charge separation to enhance photovoltaic efficiency of solution-processed thin film solar cells.

  19. Hydrogen peroxide production from fibrous pectic cellulose analogs and effect on dermal fibroblasts

    Science.gov (United States)

    Naturally derived products with folklore remedies have in recent years been reconsidered for their benefit to wound healing i.e., honey’s application to chronic wound dressing products. Similarly, we have undertaken an evaluation of Fibrous pectin-cellulose (FPC) (cellulose blended with primary cel...

  20. Solitary fibrous tumor of the greater omentum mimicking an ovarian tumor in a young woman

    Directory of Open Access Journals (Sweden)

    Elisabet Rodriguez Tarrega

    2016-08-01

    Full Text Available We report a case of solitary fibrous tumor (SFT of greater omentum in a young woman. SFT arising from the greater omentum can mimic a gynecologic neoplasm. SFTs are generally benign but some of them are malignant and have uncertain prognosis. An adequate follow-up is essential in these patients.

  1. Fibrous tumours in children: imaging features of a heterogeneous group of disorders

    Energy Technology Data Exchange (ETDEWEB)

    Eich, G.F.; Hoeffel, J.C.; Tschaeppeler, H.; Gassner, I.; Willi, U.V. [Division of Diagnostic Imaging and Radiology, The University Children`s Hospital, Steinwiesstrasse 75, CH-8032 Zurich (Switzerland)

    1998-07-01

    Background. Fibrous tumours are predominantly soft tissue lesions which are relatively frequent in childhood but are little known. Imaging is often used in the evaluation of these tumours but their characteristics, particularly on US or MRI, have not been studied systematically. Objectives. To provide an overview of the clinical and imaging features of the different disorders, and to correlate them with the currently used classification schemes. Material and methods. Twenty-five patients with fibrous tumours were evaluated retrospectively. Clinical histories were studied for the histopathological diagnosis, age, signs and symptoms at presentation, mode of therapy and follow-up where available. Imaging findings were analysed for the following variables: number, location, size, margin and architecture of soft tissue and/or visceral lesions and the presence and pattern of osseous involvement. Comparison with the available literature was performed. Results. The following tumour types were encountered: desmoid fibromatosis (n = 9), myofibromatosis (n = 7), fibromatosis colli (n = 2), congenital-infantile fibrosarcoma (n = 2), adult-type fibrosarcoma (n = 2), fibrous hamartoma of infancy (n = 1), angiofibroma (n = 1) and hyaline fibromatosis (n = 1). Conclusions. While some tumours were non-specific in their clinical and radiological manifestation, others such as myofibromatosis, fibromatosis colli, fibrous hamartoma of infancy and angiofibroma exhibited a characteristic pattern which allowed a diagnosis to be made even without histology. (orig.) With 10 figs., 1 tab., 20 refs.

  2. Estimating the Sabine absorption coefficient of fibrous materials for various backing conditions

    DEFF Research Database (Denmark)

    Jeong, Cheol-Ho

    2017-01-01

    conditions by extracting the air flow resistivity of the test specimen and the frequency-dependent effect of the chamber on the measured absorption coefficients. Two homogeneous fibrous absorbers are measured for experimental validation, showing good agreements between the predictions and measurements...

  3. 3D multi-layered fibrous cellulose structure using an electrohydrodynamic process for tissue engineering.

    Science.gov (United States)

    Kim, Minseong; Kim, GeunHyung

    2015-11-01

    Micro/nanofibrous structures have been applied widely in various tissue-engineering applications because the topological structures are similar to the extracellular matrix (ECM), which encourages a high degree of cell adhesion and growth. However, it has been difficult to produce a three-dimensional (3D) fibrous structure using controllable macro-pores. Recently, cellulose has been considered a high-potential natural-origin biomaterial, but its use in 3D biomedical structures has been limited due to its narrow processing window. Here, we suggest a new 3D cellulose scaffold consisting of multi-layered struts made of submicron-sized entangled fibers that were fabricated using an electrohydrodynamic direct jet (EHDJ) process that is spin-printing. By optimizing processing conditions (electric field strength, cellulose feeding rate, and distance between nozzle and target), we can achieve a multi-layered cellulose structure consisting of the cylindrically entangled cellulose fibers. To compare the properties of the fabricated 3D cellulose structure, we used a PCL fibrous scaffold, which has a similar fibrous morphology and pore geometry, as a control. The physical and in vitro biocompatibilities of both fibrous scaffolds were assessed using human dermal fibroblasts, and the cellulose structure showed higher cell adhesion and metabolic activities compared with the control. These results suggest the EHDJ process to be an effective fabricating tool for tissue engineering and the cellulose scaffold has high potential as a tissue regenerative material.

  4. Cell alignment induced by anisotropic electrospun fibrous scaffolds alone has limited effect on cardiomyocyte maturation

    Directory of Open Access Journals (Sweden)

    Jingjia Han

    2016-05-01

    Full Text Available Enhancing the maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs will facilitate their applications in disease modeling and drug discovery. Previous studies suggest that cell alignment could enhance hPSC-CM maturation; however, the robustness of this approach has not been well investigated. To this end, we examined if the anisotropic orientation of hPSC-CMs imposed by the underlying aligned fibers within a 3D microenvironment could improve the maturation of hPSC-CMs. Enriched hPSC-CMs were cultured for two weeks on Matrigel-coated anisotropic (aligned and isotropic (random polycaprolactone (PCL fibrous scaffolds, as well as tissue culture polystyrenes (TCPs as a control. As expected, hPSC-CMs grown on the two types of fibrous scaffolds exhibited anisotropic and isotropic orientations, respectively. Similar to cells on TCPs, hPSC-CMs cultured on these scaffolds expressed CM-associated proteins and were pharmacologically responsive to adrenergic receptor agonists, a muscarinic agonist, and a gap junction uncoupler in a dose-dependent manner. Although hPSC-CMs grown on anisotropic fibrous scaffolds displayed the highest expression of genes encoding a number of sarcomere proteins, calcium handling proteins and ion channels, their calcium transient kinetics were slower than cells grown on TCPs. These results suggest that electrospun anisotropic fibrous scaffolds, as a single method, have limited effect on improving the maturation of hPSC-CMs.

  5. Fibrous scaffolds made by co-electrospinning soluble eggshell membrane protein with biodegradable synthetic polymers.

    Science.gov (United States)

    Xiong, Xi; Li, Qiang; Lu, Jian-Wei; Guo, Zhao-Xia; Sun, Zhao-Hui; Yu, Jian

    2012-01-01

    Soluble eggshell membrane protein (SEP), isolated from natural eggshell membrane, was co-electrospun with biodegradable synthetic polymers poly(propylene carbonate) (PPC) and poly(lactic acid) (PLA) in various proportions from 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) solutions in order to prepare fibrous scaffolds having simultaneously good mechanical properties and biocompatibility. The fiber morphology was observed by field emission scanning electron microscopy, showing uniform fibers with diameter of 1.2-1.0 and 1.3-0.7 um for PPC/SEP and PLA/SEP blend fibers, respectively. Transmission electron microscopy observation shows that the blend fibers have domain-matrix phase morphology with fiber-like SEP domains in the PPC or PLA matrix, indicating the occurrence of phase separation, although interaction exists between PPC (or PLA) and SEP, as revealed by attenuated total reflectance Fourier transform infrared spectroscopy. The mechanical properties were evaluated by uniaxial tensile tests and showed that both the tensile strength and elongation at break increase with increasing incorporation of PPC (or PLA). The surface composition was investigated by X-ray photoelectron spectroscopy and SEP was found on the fiber surfaces, and as a result the surfaces of the fibrous scaffolds are superhydrophilic. NIH3T3 cell culture tests demonstrate that the PPC/SEP and PLA/SEP blend fibrous scaffolds have a much improved biocompatibility compared to pure PPC or PLA fibrous scaffolds.

  6. Controlled Smart Anisotropic Unidirectional Spreading of Droplet on a Fibrous Surface.

    Science.gov (United States)

    Zhang, Miaoxin; Wang, Lei; Hou, Yongping; Shi, Weiwei; Feng, Shile; Zheng, Yongmei

    2015-09-09

    Smart anisotropic-unidirectional spreading is displayed on a wettable-gradient-aligned fibrous surface due to a synergetic directing effect from the aligned structure and the ratio of hydrophilic components. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Osteoarthritis of the hip in fibrous dysplasia of the proximal femur.

    Science.gov (United States)

    Kim, H-S; Im, S B; Han, I

    2015-07-01

    Deformity of the proximal femur in fibrous dysplasia leads to deviation of the mechanical axis of the hip, which may lead to the development of secondary osteoarthritis (OA). This study investigated the prevalence and predisposing factors for the development of OA in patients with fibrous dysplasia of the proximal femur. We reviewed the records of 209 patients from our institutional database with fibrous dysplasia of the proximal femur, investigating possible predisposing factors including patient demographics, the extent of the coxa vara deformity, the presence of peri-articular disease, and the overall burden of skeletal disease. Of the 209 patients, 24 (12%) had radiological evidence of OA in the ipsilateral hip. The prevalence was significantly higher in patients with polyostotic fibrous dysplasia compared with those with monostotic disease (p dysplasia have a high risk of developing secondary OA of the hips. This risk is higher in patients with peri-articular disease, and those with a more severe deformity of proximal femur. ©2015 The British Editorial Society of Bone & Joint Surgery.

  8. CARBONIZED FIBROUS RESIN AS A NEW SORBENT FOR SAMPLING POLYCYCLIC AROMATIC HYDROCARBONS (PAHS) IN AMBIENT AIR

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A new sampling method of ambient air analysis using carbonized fibrous resin as asorbent for polycyclic aromatic hydrocarbons (PAHs) was reported.The physical and chemical properties of the carbonized fibrous resins were measured. Thesample pretreatment with ultrasonic extraction and subsequent clean-up ehition through a silica gelcolumn was optimized. The suitable ultrasonic extraction conditions were selected as follows: resinweight was 1.5 g, ultrasonic extraction time 20 min, volume of extraction solvent 100 mi andextraction operation times 2~3. The concentrated extractable organic matter was submitted to nextstep of clean-up procedure of adsorption chromatography on silica gel column/n-hexane and amixture of dichloromethene:n-hexane solution 2:3 (v/v). The PAHs fractions in the real samplesfrom Changzhou, China were particularly analyzed using GC-MS data system and the data of massspectra, retention times and scan numbers of the real samples were compared with that of thestandards of 16 PAHs listed by the US EPA as "priority pollutants" of the environment. Theanalysis of the real samples indicates that the carbonized fibrous resin is a good sorbent. Thepretreatment of samples of ambient air with carbonized fibrous resin as a sorbent for P,AHs isproved to be reliable and might be used for the procedure of the determination of PAHs inatmospheric environment.

  9. Maxillary fibrous dysplasia associated with McCune-Albright syndrome. A case study

    Directory of Open Access Journals (Sweden)

    Wójcik Sylwia

    2016-01-01

    Full Text Available McCune Albright syndrome (MCA is a rare complication of genetic origin. The authors present a case study of a patient with MCA diagnosed with multifocal fibrous dysplasia in his limb and craniofacial bones. The symptoms of the disease in the patient’s facial and oral tissue and the treatment administered have been described.

  10. Spinal polyostotic fibrous dysplasia in two adults: Does only biopsy unravel the mystery?

    Directory of Open Access Journals (Sweden)

    Abhay Gundgurthi

    2013-01-01

    Full Text Available Polyostotic fibrous dysplasia is a rare non-inheritable genetic disease due to mutation in GNAS gene. Here we present two adults who were accidentally detected lytic lesions in spine and after extensive evaluation for malignancies; was diagnosed on biopsy. Current concept of the disease and management is discussed.

  11. Maxillary fibrous dysplasia associated with McCune-Albright syndrome. A case study.

    Science.gov (United States)

    Wójcik, Sylwia; Koszowski, Rafał; Drozdowska, Bogna; Śmieszek-Wilczewska, Joanna; Raczkowska-Siostrzonek, Agnieszka

    2016-01-01

    McCune Albright syndrome (MCA) is a rare complication of genetic origin. The authors present a case study of a patient with MCA diagnosed with multifocal fibrous dysplasia in his limb and craniofacial bones. The symptoms of the disease in the patient's facial and oral tissue and the treatment administered have been described.

  12. Maxillary fibrous dysplasia associated with McCune-Albright syndrome. A case study

    OpenAIRE

    Wójcik Sylwia; Koszowski Rafał; Drozdowska Bogna; Śmieszek-Wilczewska Joanna; Raczkowska-Siostrzonek Agnieszka

    2016-01-01

    McCune Albright syndrome (MCA) is a rare complication of genetic origin. The authors present a case study of a patient with MCA diagnosed with multifocal fibrous dysplasia in his limb and craniofacial bones. The symptoms of the disease in the patient’s facial and oral tissue and the treatment administered have been described.

  13. Continuous Degradation of Chitosan in a Convoluted Fibrous Bed Bioreactor with Immobilized Trichoderma reesei

    Institute of Scientific and Technical Information of China (English)

    WUMianbin; XIALiming; 等

    2002-01-01

    Continuous hydrolysis of chitosan was performed in a convoluted fibrous bed bioreactor (CFBB) with immobilized T. reesei. At dilution rate of 0.4d-1 and substrate concentration of 2% (mass vs. volume), the average degree of polymerization of hydrolysate can be kept at 1.25-1.35, which can be easily regulated by changing dilution rate or inlet chitosan concentration.

  14. Surgical treatment of denture-induced fibrous hyperplasia with plasma rich in growth factors.

    Science.gov (United States)

    Mozzati, Marco; Mortellaro, Carmen; Gallesio, Giorgia; Ruggiero, Tiziana; Pol, Renato

    2015-05-01

    Denture-induced fibrous hyperplasia is a fibrous connective tissue lesion that commonly occurs in oral mucosa in patients showing important alveolar ridge atrophy. In this study, we propose Plasma Rich in Growth Factors (PRGF) to overcome constrains of traditional surgical treatment. Herein, we demonstrated that PRGF represents an autologous source of growth factors able to reduce the healing time of the alveolar mucosa and the discomfort of those patients. These properties are the result of PRGF's precise biological features that result in the following: reduction of duration and intensity of postsurgical pain, acceleration of re-epithelialization of the wound, and reduction of bleeding events and of edema. In conclusion, we showed that using PRGF on patients affected by denture-induced fibrous hyperplasia allows a short healing time, thereby reducing complications and overall improving their quality of life. The aims of this study were to evaluate the influence of PRGF-ENDORET on secondary re-epithelialization in vestibuloplasty after excision of denture irritation fibrous hyperplasia, with an explorative randomized case control trial with 10 patients, 5 patients treated with PRGF and 5 patients with traditional hemostasis, and to analyze differences with simple surgery, considering postoperative rapidity of re-epithelialization, comfort, and discomfort of patients, pain, swelling, and infections.

  15. Solitary Fibrous Tumor of the Prostate Which Was Initially Misdiagnosed as Prostate Cancer

    Science.gov (United States)

    Osamu, Soma; Murasawa, Hiromi; Yoneyama, Takahiro; Koie, Takuya; Ohyama, Chikara

    2017-01-01

    Solitary fibrous tumor (SFT) of the prostate is a very rare tumor. We report a case of 65-year-old man with SFT of the prostate which was initially misdiagnosed as prostate cancer. Finally, we performed total prostatectomy and the tumor was histologically diagnosed as SFT of the prostate. The patient's clinical course has progressed favorably with no obvious recurrence 18 months postoperatively.

  16. Atherosclerotic plaque fibrous cap assessment under an oblique scan plane orientation in carotid MRI

    NARCIS (Netherlands)

    Nieuwstadt, H.A.; Van der Lugt, A.; Kassar, Z.A.M.; Breeuwer, M.; Van der Steen, A.F.W.; Gijsen, F.J.H.

    2014-01-01

    Carotid magnetic resonance imaging (MRI) is used to noninvasively assess atherosclerotic plaque fibrous cap (FC) status, which is closely related to ischemic stroke. Acquiring anisotropic voxels improves in-plane visualization, however, an oblique scan plane orientation could then obscure a FC (i.e.

  17. Dedifferentiated chondrosarcoma arising in fibrous dysplasia: A case report and review of the current literature

    Directory of Open Access Journals (Sweden)

    Nicole MD Riddle

    2009-06-01

    Full Text Available Nicole MD Riddle1, Hideko Yamauchi2, Jamie T Caracciolo4, David Johnson2, G Douglas Letson2, Ardeshir Hakam1,3, Prudence V Smith1,2,3, Marilyn M Bui1,2,31Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA; 2Department of Sarcoma, 3Department of Anatomic Pathology, 4Department of Radiology, Moffitt Cancer Center, Tampa, FL, USABackground: Fibrous dysplasia is an uncommon bone disease that has rare but clear potential for malignant transformation. The frequency is increased in polyostotic forms, McCune–Albright syndrome, Mazabraud’s syndrome, and previously irradiated sites. Rapidly progressing pain unrelated to trauma is the most concerning symptom. The early radiological features of sarcomatous transformation are moth-eaten or cystic areas of osteolysis, cortical destruction, and gradual formation of a soft tissue mass. The prognosis is unfavorable as most of the cases are in an advanced stage at the time of diagnosis.Methods: This case was diagnosed at a large cancer center in Florida. Pertinent clinical findings were obtained from chart review and inter-departmental consultation.Results: Histopathological examination revealed dysplastic lamellar bone with no osteoblastic rimming and “Chinese letter” shapes, areas composed of lobulated hyaline cartilage with mild to severe nuclear atypia, and areas of poorly differentiated cells with a spindled appearance, consistent with chondrosarcoma arising within fibrous dysplasia.Conclusions: Sarcomatous transformation of fibrous dysplasia is an uncommon occurrence, yet has significant importance for those with the disease. There may be difficulty with diagnosis given the symptoms and radiologic findings of benign fibrous dysplasia. We report a case of chondrosarcoma rising in fibrous dysplasia and review the current literature. This case is of interest due to the fact that the diagnosis of monostotic fibrous dysplasia was first made at the age of 59 and

  18. Combined Heat Transfer in High-Porosity High-Temperature Fibrous Insulations: Theory and Experimental Validation

    Science.gov (United States)

    Daryabeigi, Kamran; Cunnington, George R.; Miller, Steve D.; Knutson, Jeffry R.

    2010-01-01

    Combined radiation and conduction heat transfer through various high-temperature, high-porosity, unbonded (loose) fibrous insulations was modeled based on first principles. The diffusion approximation was used for modeling the radiation component of heat transfer in the optically thick insulations. The relevant parameters needed for the heat transfer model were derived from experimental data. Semi-empirical formulations were used to model the solid conduction contribution of heat transfer in fibrous insulations with the relevant parameters inferred from thermal conductivity measurements at cryogenic temperatures in a vacuum. The specific extinction coefficient for radiation heat transfer was obtained from high-temperature steady-state thermal measurements with large temperature gradients maintained across the sample thickness in a vacuum. Standard gas conduction modeling was used in the heat transfer formulation. This heat transfer modeling methodology was applied to silica, two types of alumina, and a zirconia-based fibrous insulation, and to a variation of opacified fibrous insulation (OFI). OFI is a class of insulations manufactured by embedding efficient ceramic opacifiers in various unbonded fibrous insulations to significantly attenuate the radiation component of heat transfer. The heat transfer modeling methodology was validated by comparison with more rigorous analytical solutions and with standard thermal conductivity measurements. The validated heat transfer model is applicable to various densities of these high-porosity insulations as long as the fiber properties are the same (index of refraction, size distribution, orientation, and length). Furthermore, the heat transfer data for these insulations can be obtained at any static pressure in any working gas environment without the need to perform tests in various gases at various pressures.

  19. Electrochemical characterization of electrospun nanocomposite polymer blend electrolyte fibrous membrane for lithium battery.

    Science.gov (United States)

    Padmaraj, O; Rao, B Nageswara; Venkateswarlu, M; Satyanarayana, N

    2015-04-23

    Novel hybrid (organic/inorganic) electrospun nanocomposite polymer blend electrolyte fibrous membranes with the composition poly(vinylidene difluoride-co-hexafluoropropylene) [P(VdF-co-HFP)]/poly(methyl methacrylate) [P(MMA)]/magnesium aluminate (MgAl2O4)/LiPF6 were prepared by the electrospinning technique. All of the prepared electrospun P(VdF-co-HFP), PMMA blend [90% P(VdF-co-HFP)/10% PMMA], and nanocomposite polymer blend [90% P(VdF-co-HFP)/10% PMMA/x wt % MgAl2O4 (x = 2, 4, 6, and 8)] fibrous membranes were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. The fibrous nanocomposite separator-cum-polymer blend electrolyte membranes were obtained by soaking the nanocomposite polymer blend membranes in an electrolyte solution containing 1 M LiPF6 in ethylene carbonate (EC)/diethyl carbonate (DEC) (1:1, v/v). The newly developed fibrous nanocomposite polymer blend electrolyte [90% P(VdF-co-HFP)/10% PMMA/6 wt % MgAl2O4/LiPF6] membrane showed a low crystallinity, low average fiber diameter, high thermal stability, high electrolyte uptake, high conductivity (2.60 × 10(-3) S cm(-1)) at room temperature, and good potential stability above 4.5 V. The best properties of the fibrous nanocomposite polymer blend electrolyte (NCPBE) membrane with a 6 wt % MgAl2O4 filler content was used for the fabrication of a Li/NCPBE/LiCoO2 CR 2032 coin cell. The electrochemical performance of the fabricated CR 2032 cell was evaluated at a current density of 0.1 C-rate. The fabricated CR 2032 cell lithium battery using the newly developed NCPBE membrane delivered an initial discharge capacity of 166 mAh g(-1) and a stable cycle performance.

  20. Statistical model for the mechanical behavior of the tissue engineering non-woven fibrous matrices under large deformation.

    Science.gov (United States)

    Rizvi, Mohd Suhail; Pal, Anupam

    2014-09-01

    The fibrous matrices are widely used as scaffolds for the regeneration of load-bearing tissues due to their structural and mechanical similarities with the fibrous components of the extracellular matrix. These scaffolds not only provide the appropriate microenvironment for the residing cells but also act as medium for the transmission of the mechanical stimuli, essential for the tissue regeneration, from macroscopic scale of the scaffolds to the microscopic scale of cells. The requirement of the mechanical loading for the tissue regeneration requires the fibrous scaffolds to be able to sustain the complex three-dimensional mechanical loading conditions. In order to gain insight into the mechanical behavior of the fibrous matrices under large amount of elongation as well as shear, a statistical model has been formulated to study the macroscopic mechanical behavior of the electrospun fibrous matrix and the transmission of the mechanical stimuli from scaffolds to the cells via the constituting fibers. The study establishes the load-deformation relationships for the fibrous matrices for different structural parameters. It also quantifies the changes in the fiber arrangement and tension generated in the fibers with the deformation of the matrix. The model reveals that the tension generated in the fibers on matrix deformation is not homogeneous and hence the cells located in different regions of the fibrous scaffold might experience different mechanical stimuli. The mechanical response of fibrous matrices was also found to be dependent on the aspect ratio of the matrix. Therefore, the model establishes a structure-mechanics interdependence of the fibrous matrices under large deformation, which can be utilized in identifying the appropriate structure and external mechanical loading conditions for the regeneration of load-bearing tissues.

  1. Mobility of Power-law and Carreau Fluids through Fibrous Media

    CERN Document Server

    Shahsavari, Setareh

    2015-01-01

    The flow of generalized Newtonian fluids with a rate-dependent viscosity through fibrous media is studied with a focus on developing relationships for evaluating the effective fluid mobility. Three different methods have been used here: i) a numerical solution of the Cauchy momentum equation with the Carreau or power-law constitutive equations for pressure-driven flow in a fiber bed consisting of a periodic array of cylindrical fibers, ii) an analytical solution for a unit cell model representing the flow characteristics of a periodic fibrous medium, and iii) a scaling analysis of characteristic bulk parameters such as the effective shear rate, the effective viscosity, geometrical parameters of the system, and the fluid rheology. Our scaling analysis yields simple expressions for evaluating the transverse mobility functions for each model, which can be used for a wide range of medium porosity and fluid rheological parameters. While the dimensionless mobility is, in general, a function of the Carreau number an...

  2. Frontal sinus mucocele in association with fibrous dysplasia: review and report of two cases.

    Science.gov (United States)

    Derham, Chris; Bucur, Sorin; Russell, John; Liddington, Mark; Chumas, Paul

    2011-02-01

    We present two paediatric cases of fibrous dysplasia (FD) who presented to the craniofacial neurosurgical clinic with ophthalmological symptoms associated with sinus mucoceles. The first patient presented with a history of orbital cellulitis and an increasing bony swelling around the orbit associated with proptosis. Radiological imaging revealed monostotic FD associated with an obstructive mucocele in the frontal sinus with extension into the orbit. The second patient presented with recurrent conjunctivitis, painful proptosis, rhinitis and a bony peri-orbital swelling. Both patients had histological diagnoses of frontal mucoceles invading the orbit in association with FD. They both underwent frontal craniotomies and excision of the mucocele/fibrous dysplastic complex. In summary, mucocele development is an unusual complication of FD, likely to occur secondary to occlusion of the sinus drainage system. Orbital involvement may lead to visual disturbance caused by pressure effects. A multi-disciplinary approach including maxillofacial surgeons, plastic surgeons and neurosurgeons is advocated.

  3. High Temperature Thermal Physical Properties of High-alumina Fibrous Insulation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The thermal properties of high-alumina fibrous insulation which filled in metallic thermal protection system were investigated. The effective thermal conductivities of the fibrous insulation were measured under an atmospheric pressure from 10-2 to 105 Pa. In addition, the changes of the specific heat and Rosseland mean extinction coefficient were experimentally determined under various surrounding temperatures up to 973 K.The spectral extinction coefficients were obtained from transmittance data in the wavelength range of 2.5-25 μm using Beer's law. Rosseland mean extinction coefficients as a function of temperature were calculated based on spectral extinction coefficients at various temperatures. The results show that thermal conductivities of the sample increase with increasing temperature and pressure. Specific heat increases as temperature increases, which shows that the capacity of heat absorption increases gradually with temperature. Rosseland mean extinction coefficients of the sample decrease firstly and then increase with increasing the temperature.

  4. Preparation and Charactrization of Fibrous Crystals of Boron-containing MTW-type Zeolite

    Institute of Scientific and Technical Information of China (English)

    SONG, Mao-Ying(宋茂莹); ZHOU, Wei-Zheng(周伟正); LONG, Ying-Cai(龙英才)

    2004-01-01

    Fibrous crystals of boron-containing MTW-type zeolite have been hydrothermally synthesized in B2O3-SiO2-HF-H2O gel system at 170 ℃ in 20 to 28 d by using 1,4-diazabicyclo[2,2,2]octane (DABCO) and methylamine as the co-template, and characterized with XRD, SEM, TEM, HRTEM and SAED. The results of characterizations show that B atoms are incorporated into the zeolite framework as tetrahedron of B(Osi)4. The fibrous single crystals of 5-50 μm in length and 100-500 nm in width inter-grow along the c-axis of the zeolite, and the one dimension 12 oxygen ring channels are perpendicular to the fibber axis.

  5. Primary Giant Cell Malignant Fibrous Histiocytoma of the Kidney with Staghorn Calculi

    Directory of Open Access Journals (Sweden)

    Chen C

    2003-01-01

    Full Text Available Malignant fibrous histiocytomas (MFH as primary renal tumours are rare, with less than 50 cases described in the literature. We report a case of primary renal MFH of giant cell type in a 56-year-old man, who presented with bilateral dull flank pain, intermittent gross haematuria and body weight loss (6 kg in 3 months. Intravenous urography, computerized tomography (CT and magnetic resonance image (MRI showed right ureteral stones with mild hydronephrosis, and a solid mass at the lower pole of the left kidney associated with staghorn calculi, as well as tumour thrombi in the left renal vein and inferior vena cava. Left radical nephrectomy and evacuation of tumour thrombi from the left renal vein and inferior vena cava were performed. Histopathologic examination revealed malignant fibrous histiocytoma (MFH of giant cell type. To the best of our knowledge, this is the first report of primary renal MFH associated with staghorn calculi.

  6. Mimicking natural fibrous structures of opals by means of a microemulsion-mediated hydrothermal method.

    Science.gov (United States)

    Hassan, Natalia; Verdinelli, Valeria; Ruso, Juan M; Messina, Paula V

    2011-07-19

    Silica-based nanomaterials are of great interest because of their potential applications in constructing electronic and optoelectronic nanodevices. Especially significant are those that combine the properties of photonic crystal with a fibrous semiconductor structure. Here we report the use of microemulsion droplet systems as a simple and controllable route for the synthesis of 3D opals materials with an unusual fibrous microstructure similar to those that exist in nature. By this method, we demonstrate the creation of very long fibrils of 30-50 nm diameter and more than 20 μm length showing simultaneous short and long wavelength light emissions and band gap values (5.50 and 4.41 eV) comparable to those obtained for silicon-based metal oxide semiconductors.

  7. A Network Model for the Effective Thermal Conductivity of Rigid Fibrous Refractory Insulations

    Science.gov (United States)

    Marschall, Jochen; Cooper, D. M. (Technical Monitor)

    1995-01-01

    A procedure is described for computing the effective thermal conductivity of a rigid fibrous refractory insulation. The insulation is modeled as a 3-dimensional Cartesian network of thermal conductance. The values and volume distributions of the conductance are assigned to reflect the physical properties of the insulation, its constituent fibers, and any permeating gas. The effective thermal conductivity is computed by considering the simultaneous energy transport by solid conduction, gas conduction and radiation through a cubic volume of model insulation; thus the coupling between heat transfer modes is retained (within the simplifications inherent to the model), rather than suppressed by treating these heat transfer modes as independent. The model takes into account insulation composition, density and fiber anisotropy, as well as the geometric and material properties of the constituent fibers. A relatively good agreement, between calculated and experimentally derived thermal conductivity values, is obtained for a variety of rigid fibrous insulations.

  8. Gastric calcifying fibrous tumor: A case of suspected immunoglobulin G4-related gastric disease

    Directory of Open Access Journals (Sweden)

    Hejun Zhang

    2015-01-01

    Full Text Available Gastrointestinal lesions resulting from immunoglobulin G4-related disease are classified into two types: One is a gastrointestinal lesion showing marked thickening of the wall, and the other is an IgG4-related pseudotumor. We report the case of a woman with gastric calcifying fibrous tumor undergoing endoscopic resection that contained 62 IgG4+ plasma cells per high-power field and an IgG4-to-IgG ratio of 41% in lesional plasma cells, which shared clinical and histopathological features associated with gastric IgG4-related pseudotumor. So, we postulate that calcifying fibrous tumor as part of the spectrum of IgG4-related disease might be the unifying concept with IgG4-related pseudotumor. Meanwhile, the patient had coexistent autoimmune diseases, including autoimmune atrophic gastritis, Hashimoto's thyroiditis, and possible primary biliary cirrhosis. The clinical follow-up evaluation was uneventful.

  9. Theoretical study of the fibrous capsule tissue growth around a disk-shaped implant

    KAUST Repository

    Djellouli, Rabia

    2012-08-19

    We analyze the mathematical properties of the fibrous capsule tissue concentration around a disk-shaped implant. We establish stability estimates as well as monotonicity results that illustrate the sensitivity of this growth to the biocompatibility index parameters of the implant. In addition, we prove that the growth of the tissue increases exponentially in time toward an asymptotic regime. We also study the mathematical properties of the solution of the inverse problem consisting in the determination of the values of the biocompatibility index parameters from the knowledge of some fibrous capsule tissue measurements. We prove that this model calibration problem admits a unique solution, and establish a characterization of the index parameters. Furthermore, we demonstrate analytically that such a solution is not continuous with respect to the data, and therefore the considered inverse problem is ill-posed due to the lack of the stability requirement. © 2012 Springer-Verlag.

  10. Solitary fibrous tumor/hemangiopericytoma of the penis: Report of the first case.

    Science.gov (United States)

    Castellani, Daniele; Sebastiani, Giancarlo; Maurelli, Simone; Andrisano, Alessandro; Mazzone, Luigi; Feroce, Antonio; Primi, Francesca; Verrico, Giovanna; Rizzotto, Antonio

    2015-01-01

    Hemangiopericytoma (HPC) is an uncommon perivascular tumor, first described in 1942, occurring most frequently in the extremities (pelvis, meninges, head and neck), and rarely affecting the urogenital system. In 1870, Wagner published the first histological description of a Solitary Fibrous Tumor (SFT) of the pleura. It is now thought that the majority of lesions previously called hemangiopericytomas (HPCs) are essentially indistinguishable from solitary fibrous tumors (SFTs). Nowadays, the new WHO classification of soft tissue tumors categorizes most HPCs as SFTs. We report the first case of penile SFT-HPC in a 44-year-old man, presenting with a 3-year history of slow-growing penile mass. The patient underwent a tumor excision. Six months after surgery he is free of local recurrence and distant metastasis.

  11. Shepherd's Crook Deformity of Polyostotic Fibrous Dysplasia Treated with Corrective Osteotomy and Dynamic Hip Screw

    Directory of Open Access Journals (Sweden)

    Wei-Jen Chen

    2005-07-01

    Full Text Available Fibrous dysplasia, a condition in which the skeleton fails to develop normally, is characterized by fibroblastic stroma and immature bone. Bowing of the long bones occurs frequently in the polyostotic form, and stress fractures often result. Shepherd's crook deformity is a characteristic feature of fibrous dysplasia. The goal of its treatment is to obtain normal walking ability and relieve pain due to pathologic fracture secondary to the deformity; however, correction of the deformity is a surgical challenge. We present 2 cases of shepherd's crook deformity treated with corrective osteotomy and a dynamic hip screw. Both cases showed good bone healing and no recurrent deformity. The gross deformities were corrected, and both patients were pain-free after operation.

  12. Fat-forming variant of solitary fibrous tumor of the mediastinum

    Institute of Scientific and Technical Information of China (English)

    LIU Xi; ZHANG Hong-ying; BU Hong; MENG Guo-zhao; ZHANG Zhang; KE Qi

    2007-01-01

    @@ Fat-forming variant of solitary fibrous tumor (fat-forming variant of SFT), previously called lipomatous hemangiopericytoma (L-HPC), is a recently recognized rare variant of solitary fibrous tumor (SFT)with unpredictable biologic behavior. Fat-forming variant of SFT occurs predominately in the deep soft tissues of the lower extremities. Histologically, it is composed of an admixture of benign hemangiopericytomatous and lipomatous components. Up to now, only 37 cases have been reported in the English literature worldwide1-7 and the molecular analyses are sparse. Reported herein is the first Chinese case of fat-forming variant of SFT. Although one case of fat-forming variant of SFT in the mediastinum was briefly reported, this is the first case in the region with detailed histologic, immunohistochemical features and flow cytometric DNA analysis.

  13. Supporting structural components of fibrous composite materials in coach design; Tragende Strukturteile aus Faserverbundkunststoffen im Omnibusbau

    Energy Technology Data Exchange (ETDEWEB)

    Lee, R.; Bartha, E. [Gottlob Anwaerther GmbH und Co., Stuttgart (Germany)

    1997-11-01

    This article is dealing with the possibilities for coach designers in using Fibrous composite materials like FGRP ans CFK. There are examples shown for three dimensional curved prefabricated parts in Fibrous composite method of Building (Sandwhich) forsupporting components. On the examples of an `integral front` are the advantages shown of such a construction in few of weight, manufacturing costs, resistance and working life. Coach specific particularities are taken particulary in consideration. (orig.) [Deutsch] Die Verwendung faserverstaerkter Kunststoffe als Werkstoff fuer die Karosserieaussenhaut hat sich beim Omnibusbau insbesondere aus Gruenden der einfachen dreidimensionalen Formbarkeit grossflaechig durchgesetzt. Verglichen mit gepressten Stahlblech-Formteilen, wie bei Pkw-Karosserien ueblich, lassen sich die vergleichsweise geringen Stueckzahlen bei Omnibussen in Kunststoff-Formen wirtschaftlich fertigen. Am Beispiel des Cityliners, einem Fernreisebus von Neoplan, wird der Einsatz faserverstaerkter tragende Karosserieteile mit UP-Harz-Matrix dargestellt. (orig.)

  14. Welcome to Fibers—A New Open Access Journal for Fibrous Material Science

    Directory of Open Access Journals (Sweden)

    Stephen C. Bondy

    2012-08-01

    Full Text Available Fibers are materials in the form of elongated threads. They can possess elastic features that are relevant to the integrity and bonding of cells. These features also give man-made fibers a wide range of applications. The large ratio of length to width (aspect ratio, which defines fibers, strongly influences their physical and chemical properties. This quality gives them a relatively large surface area, which can lead to powerful tensile and absorptive characteristics, which are remarkably different from, and cannot be predicted by study of the non-fibrous parent materials. An example of this is asbestos, where the toxicity of the material is heavily influenced by its structural anatomy. Distinctive chemical processes can take place on fibrous surfaces that may themselves seem to be chemically inert. Certain commonalities result from the distinctive geometry of fibers, and lie behind the apparently great diversity of fiber types and materials. [...

  15. Two-Scale Modeling Approach to Predict Permeability of Fibrous Media

    OpenAIRE

    Sudhakar Jaganathan; Behnam Pourdeyhimi, Ph.D.; Hooman V. Tafreshi, Ph.D.

    2008-01-01

    We previously demonstrated how one can develop a 3-D geometry to model the fibrous microstructure of a nonwoven fiberweb and use it to simulate its permeability at fiber level [1-6]. Developing 3-D models of most nonwoven fabrics (bonded fiberwebs), however, is cumbersome, as in the case of hydroentangled fabrics, for instance. In such cases, microscopic techniques are often used to generate 3-D images of the media’s microstructures. Nevertheless, whether the microstructure is modeled or obta...

  16. AN ANISOTROPIC NANOFIBER/MICROSPHERE COMPOSITE WITH CONTROLLED RELEASE OF BIOMOLECULES FOR FIBROUS TISSUE ENGINEERING

    OpenAIRE

    Ionescu, Lara C.; Lee, Gregory C.; Sennett, Brian J.; Burdick, Jason A.; Mauck, Robert L.

    2010-01-01

    Aligned nanofibrous scaffolds can recapitulate the structural hierarchy of fiber-reinforced tissues of the musculoskeletal system. While these electrospun fibrous scaffolds provide physical cues that can direct tissue formation when seeded with cells, the ability to chemically guide a population of cells, without disrupting scaffold mechanical properties, would improve the maturation of such constructs and add additional functionality to the system both in vitro and in vivo. In this study, we...

  17. An Atypical Presentation of Multiple Central Osteomas Mimicking Craniofacial Fibrous Dysplasia – A Pictorial Essay

    Science.gov (United States)

    Mhapuskar, Amit A; Hebbale, Manjula; Tepan, Meenal; Ayushee

    2016-01-01

    Osteoma is benign neoplasm with slow growth characterized by deposition of compact lamellar cortical or cancellous bone creating a tumour mass. It is still unclear whether osteomas are benign neoplasms or hamartomas. They have typical clinical presentations and are easily diagnosed with the help of radiographs. We present a rare case of non-syndromic multiple osteomas in the craniofacial region which are typically restricted to the midline and presents radiographically as craniofacial fibrous dysplasia causing a diagnostic dilemma. PMID:28050513

  18. Gene expression profiling of craniofacial fibrous dysplasia reveals ADAMTS2 overexpression as a potential marker

    OpenAIRE

    Zhou, Shang-Hui; Yang, Wen-Jun; Liu, Sheng-Wen; Li, Jiang; Zhang, Chun-Ye; Zhu, Yun; Zhang, Chen-Ping

    2014-01-01

    Fibrous dysplasia (FD) as an abnormal bone growth is one of the common fibro-osseous leasions (FOL) in oral and maxillofacial region, however, its etiology still remains unclear. Here, we performed gene expression profiling of FD using microarray analysis to explore the key molecule events in FD development, and develop potential diagnostic markers or therapeutic targets for FD. We found that 1,881 genes exhibited differential expression with more than two-fold changes in FD compared to norma...

  19. Simulating transport in and entrainment form nonwoven fibrous, knitted, and opne-cell foam filters

    OpenAIRE

    Golkarfard, V.; Mullins, B; King, A.; Abishek, S.; Kasper, G; Heikamp, W.

    2016-01-01

    The movement and re-entrainment of liquid droplets from three different filter media, namely fibrous, knitted, and open-cell foam was investigated numerically using computational fluid dynamics (CFD). A range of face velocities were considered which resulted in a range of oil transform rates and steady state saturation levels. It will be shown that liquid volume fraction in filters depends on velocity and time. The minimum velocity required for detachment of droplets was also identified. The ...

  20. [Optimization of dissolution process for superfine grinding technology on total saponins of Panax ginseng fibrous root by response surface methodology].

    Science.gov (United States)

    Zhao, Ya; Lai, Xiao-Pin; Yao, Hai-Yan; Zhao, Ran; Wu, Yi-Na; Li, Geng

    2014-03-01

    To investigate the effects of superfine comminution extraction technology of ginseng total saponins from Panax ginseng fibrous root, and to make sure the optimal extraction condition. Optimal condition of ginseng total saponins from Panax ginseng fibrous root was based on single factor experiment to study the effects of crushing degree, extraction time, alcohol concentration and extraction temperature on extraction rate. Response surface method was used to investigate three main factors such as superfine comminution time, extraction time and alcohol concentration. The relationship between content of ginseng total saponins in Panax ginseng fibrous root and three factors fitted second degree polynomial models. The optimal extraction condition was 9 min of superfine comminution time, 70% of alcohol, 50 degrees C of extraction temperature and 70 min of extraction time. Under the optimal condition, ginseng total saponins from Panax ginseng fibrous root was average 94. 81%, which was consistent with the predicted value. The optimization of technology is rapid, efficient, simple and stable.

  1. Viability and activity of bifidobacteria during refrigerated storage of yoghurt containing Mangifera pajang fibrous polysaccharides.

    Science.gov (United States)

    Al-Sheraji, Sadeq Hasan; Ismail, Amin; Manap, Mohd Yazid; Mustafa, Shuhaimi; Yusof, Rokiah Mohd

    2012-11-01

    The viability and activity of Bifidobacterium pseudocatenulatum G4, B. longum BB 536 and yoghurt cultures (Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus) were studied in yoghurt containing 0.75% Mangefira pajang fibrous polysaccharides (MPFP) and inulin. Growth of probiotic organisms, their proteolytic activities, the production of short chain fatty acids (lactic, acetic and propionic) and the pH of the yoghurt samples were determined during refrigerated storage at 4 °C for 28 d. B. pseudocatenulatum G4 and B. longum BB 536 showed better growth and activity in the presence of MPFP and inulin, which significantly increased the production of short chain fatty acids as well as the proteolytic activity of these organisms. This is the first study reported on produce synbiotic yoghurt as a functional food for specified health uses contains bifidobacteria and M. pajang fibrous polysaccharides. M. pajang fibrous polysaccharides can be used as a prebiotic particularly in dairy products to increase the viability and activity of bifidobacteria which can be used as probiotic to exert health benefit to the human by yoghurt that is considered common use in society; thus, the benefits of synbiotic yoghurt are readily accessible to the member of society. © 2012 Institute of Food Technologists®

  2. Preparation of micro/nano-fibrous brushite coating on titanium via chemical conversion for biomedical applications

    Science.gov (United States)

    Liu, Bing; Guo, Yong-yuan; Xiao, Gui-yong; Lu, Yu-peng

    2017-03-01

    Calcium phosphate coatings have been applied on the surface of Ti implants to realize better osseointegration. The formation of dicalcium phosphate dihydrate (CaHPO4·2H2O), mineralogically named brushite on pure Ti substrate has been investigated via chemical conversion method. Coating composition and microstructure have been investigated by X-ray diffractometer, Fourier transform infrared spectrometer and field emission scanning electron microscope. The results reveal that the coatings are composed of high crystalline brushite with minor scholzite (CaZn2(PO4)2·2H2O). A micro/nano-scaled fibrous morphology can be produced in the acidic chemical conversion bath with pH 5.00. The surface of the fibrous brushite coating exhibits high hydrophilicity and corrosion resistance in the simulated body fluid. The osteoblast cells grow and spread actively on the coated samples and the proliferation numbers and alkaline phosphate activities of the cells improve significantly compared to the uncoated Ti. It is suggested that the micro/nano-fibrous brushite coating can be a potential approach to improve the osteoinductivity and osteoconductivity of Ti implant, due to its similarity in morphology and dimension to inorganic components of biological hard tissues, and favorable responses to the osteoblasts.

  3. Regulating Inflammation Using Acid-Responsive Electrospun Fibrous Scaffolds for Skin Scarless Healing

    Directory of Open Access Journals (Sweden)

    Ziming Yuan

    2014-01-01

    Full Text Available Skin injury in adult mammals brings about a series of events and inflammation in the wounded area is initiated first and provides lots of inflammatory factors, which is critical for the final scar formation. While the postinjured skin of fetus and nude mice heals scarlessly owing to the absence of inflammation or immunodeficient, we designed a feasible acid-responsive ibuprofen-loaded poly(L-lactide (PLLA fibrous scaffolds via doping sodium bicarbonate to prevent excessive inflammation and achieve scarless healing finally. The morphological results of in vivo experiments revealed that animals treated with acid-responsive ibuprofen-loaded PLLA fibrous scaffolds exhibited alleviative inflammation, accelerated healing process, and regulated collagen deposition via interference in the collagen distribution, the α-smooth muscle actin (α-SMA, and the basic fibroblast growth factor (bFGF expression. The lower ratios of collagen I/collagen III and TGF-β1/TGF-β3 and higher ratio of matrix metalloproteinase-1 (MMP-1/tissue inhibitor of metalloproteinase-1 (TIMP-1 in acid-responsive ibuprofen-loaded PLLA fibrous scaffolds group were confirmed by real-time qPCR as well. These results suggest that inhibiting the excessive inflammation will result in regular collagen distribution and appropriate ratio between the factors, which promote or suppress the scar formation, then decrease the scar area, and finally achieve the scarless healing.

  4. Regulating inflammation using acid-responsive electrospun fibrous scaffolds for skin scarless healing.

    Science.gov (United States)

    Yuan, Ziming; Zhao, Jingwen; Chen, Yigang; Yang, Zhili; Cui, Wenguo; Zheng, Qi

    2014-01-01

    Skin injury in adult mammals brings about a series of events and inflammation in the wounded area is initiated first and provides lots of inflammatory factors, which is critical for the final scar formation. While the postinjured skin of fetus and nude mice heals scarlessly owing to the absence of inflammation or immunodeficient, we designed a feasible acid-responsive ibuprofen-loaded poly(L-lactide) (PLLA) fibrous scaffolds via doping sodium bicarbonate to prevent excessive inflammation and achieve scarless healing finally. The morphological results of in vivo experiments revealed that animals treated with acid-responsive ibuprofen-loaded PLLA fibrous scaffolds exhibited alleviative inflammation, accelerated healing process, and regulated collagen deposition via interference in the collagen distribution, the α-smooth muscle actin (α-SMA), and the basic fibroblast growth factor (bFGF) expression. The lower ratios of collagen I/collagen III and TGF-β1/TGF-β3 and higher ratio of matrix metalloproteinase-1 (MMP-1)/tissue inhibitor of metalloproteinase-1 (TIMP-1) in acid-responsive ibuprofen-loaded PLLA fibrous scaffolds group were confirmed by real-time qPCR as well. These results suggest that inhibiting the excessive inflammation will result in regular collagen distribution and appropriate ratio between the factors, which promote or suppress the scar formation, then decrease the scar area, and finally achieve the scarless healing.

  5. Electrospinning of fibrous polymer scaffolds using positive voltage or negative voltage: a comparative study.

    Science.gov (United States)

    Tong, Ho-Wang; Wang, Min

    2010-10-01

    Electrospinning of fibrous tissue engineering scaffolds has been traditionally conducted using positive voltages. In the current study, positive voltage (PV) electrospinning and negative voltage (NV) electrospinning were investigated for forming fibrous membranes of poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV). In both PV-electrospinning and NV-electrospinning, the fiber diameter generally increased with increasing needle inner diameter and PHBV concentration but decreased with increasing working distance. The use of a conductivity-enhancing surfactant, benzyl triethylammonium chloride (BTEAC), significantly reduced PHBV fiber diameters from the micron scale to the sub-micron scale. Interestingly, with increasing applied voltage, the fiber diameter increased for PV-electrospinning but decreased for NV-electrospinning. The PV-electrospun fibrous membranes from solutions without BTEAC (PVEfm) and with BTEAC (PVEfm-B) and NV-electrospun membranes from solutions without BTEAC (NVEfm) and with BTEAC (NVEfm-B) were characterized in terms of their structure, wettability, thermal properties and tensile properties. Both PVEfm and NVEfm exhibited similar water contact angles (∼104°) but the contact angle of PVEfm-B or NVEfm-B was not measurable. The elongation at break of PVEfm-B or NVEfm-B was significantly higher than that of PVEfm or NVEfm. Using NV-electrospinning or a combination of NV- and PV-electrospinning may be very useful for developing suitable scaffolds for tissue engineering applications.

  6. Spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia: clinical and computed tomographic features in 8 cases.

    Science.gov (United States)

    Sun, Tao-Tao; Tao, Xiao-Feng; Shi, Hui-Min

    2014-07-01

    The aim of this study was to evaluate the patient demographic and computed tomography (CT) imaging findings of spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia. Ten cases of spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia diagnosed during 1993-2013 were reviewed. Eight cases with CT images were reviewed. The mean age of diagnosis of osteosarcoma was 37.8 years (range, 8-55 years). The presence of a soft tissue extension component beyond the area of cortical bone destruction was demonstrated radiographically in 7 out of 8 cases. Mineralization of tumor matrix was seen in 6 cases. Periosteal reaction was demonstrated in only 1 case; 1 out of 6 cases showed significant enhancement on postcontrast CT images. Nine patients had surgical resections of tumor. Seven of them died of tumor, with a mean survival time of 5.3 years. This study provides CT imaging features with clinical information of spontaneous osteosarcoma in craniomaxillofacial fibrous dysplasia. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Linking rock fabric to fibrous mineralisation: a basic tool for the asbestos hazard

    Directory of Open Access Journals (Sweden)

    G. Vignaroli

    2011-05-01

    Full Text Available In recent years, many studies have addressed the effect on human health caused by asbestos exposures. As asbestos is a group of fibrous minerals that mainly occurs in mafic and ultramafic rocks (ophiolitic sequences, a close relationship between asbestos occurrence and the geological history of host rocks should be expected. By reviewing the existing literature and presenting characteristic examples, it is proposed a direct correspondence exists between the presence of fibrous minerals in ophiolites and the rock fabric systematics due to the combined activity of deformation, metamorphism/metasomatism, and rock/fluid interaction. Understanding the geological factors that may be at the origin of the nucleation/growth of fibrous minerals constitutes a necessary requirement for developing a methodological and analytical procedure to evaluate asbestos hazard (AH in the natural prototype (ophiolitic rocks. A parameterisation of the AH in function of the main geological processes that produce the rock fabric systematics in different tectonic/geodynamic settings is discussed. A geological multidisciplinary approach (based on geological-structural field evidence combined with textural, mineralogical, petrological, and geochemical investigations is proposed as the prerequisite for the evaluation of AH in natural environments. This approach, in particular, can provide a robust basis to formulate a procedural protocol finalised to the mitigation of asbestos effects in environments where these effects are still a real threat.

  8. Carbon Xerogel-supported Iron as a Catalyst in Combustion Synthesis of Carbon Fibrous Nanostructures

    Institute of Scientific and Technical Information of China (English)

    Wojciech Kiciriski; Joanna Lasota

    2012-01-01

    The catalytically assisted self-propagating high-temperature synthesis of carbon fibrous nanostructures, where the iron-doped colloidal carbon xerogel is proposed as a catalyst system, was examined. The carbon xerogel was prepared through carbonization of an iron doped organic xerogel at temperatures ranging from 600 to 1050℃. The reaction between calcium carbide and hexachloroethane in the presence of sodium azide is exothermic enough to proceed at a high temperature, self-sustaining regime. The combustion reactions of those mixtures enriched with iron-doped carbon xerogels were conducted in a stainless steel reactor---calorimetric bomb under an initial pressure of 1 MPa of argon. Scanning electron microscopy analysis of the combustion products revealed low yield of various type of carbon fibers (presumably nanotubes), which grew via the tip-growth mechanism. The fibrous nanostructures were found in the vicinity of the spot of ignition, while in the outer and cooler area of the reactor, dusty products with soot-like morphology dominated. No significant correlation between the pyrolysis temperature of the carbon xerogel and the morphology of the obtained carbon fibrous nanostructures was observed.

  9. Fibrous hybrid of graphene and sulfur nanocrystals for high-performance lithium-sulfur batteries.

    Science.gov (United States)

    Zhou, Guangmin; Yin, Li-Chang; Wang, Da-Wei; Li, Lu; Pei, Songfeng; Gentle, Ian Ross; Li, Feng; Cheng, Hui-Ming

    2013-06-25

    Graphene-sulfur (G-S) hybrid materials with sulfur nanocrystals anchored on interconnected fibrous graphene are obtained by a facile one-pot strategy using a sulfur/carbon disulfide/alcohol mixed solution. The reduction of graphene oxide and the formation/binding of sulfur nanocrystals were integrated. The G-S hybrids exhibit a highly porous network structure constructed by fibrous graphene, many electrically conducting pathways, and easily tunable sulfur content, which can be cut and pressed into pellets to be directly used as lithium-sulfur battery cathodes without using a metal current-collector, binder, and conductive additive. The porous network and sulfur nanocrystals enable rapid ion transport and short Li(+) diffusion distance, the interconnected fibrous graphene provides highly conductive electron transport pathways, and the oxygen-containing (mainly hydroxyl/epoxide) groups show strong binding with polysulfides, preventing their dissolution into the electrolyte based on first-principles calculations. As a result, the G-S hybrids show a high capacity, an excellent high-rate performance, and a long life over 100 cycles. These results demonstrate the great potential of this unique hybrid structure as cathodes for high-performance lithium-sulfur batteries.

  10. Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging

    Science.gov (United States)

    He, Honghui; Sun, Minghao; Zeng, Nan; Du, E.; Liu, Shaoxiong; Guo, Yihong; Wu, Jian; He, Yonghong; Ma, Hui

    2014-10-01

    Polarization measurements are sensitive to the microstructure of tissues and can be used to detect pathological changes. Many tissues contain anisotropic fibrous structures. We obtain the local orientation of aligned fibrous scatterers using different groups of the backscattering Mueller matrix elements. Experiments on concentrically well-aligned silk fibers and unstained human papillary thyroid carcinoma tissues show that the m22, m33, m23, and m32 elements have better contrast but higher degeneracy for the extraction of orientation angles. The m12 and m13 elements show lower contrast, but allow us to determine the orientation angle for the fibrous scatterers along all directions. Moreover, Monte Carlo simulations based on the sphere-cylinder scattering model indicate that the oblique incidence of the illumination beam introduces some errors in the orientation angles obtained by both methods. Mapping the local orientation of anisotropic tissues may not only provide information on pathological changes, but can also give new leads to reduce the orientation dependence of polarization measurements.

  11. Primary Renal Malignant Fibrous Histiocytoma Four-Case Report and Review of the Literature

    Institute of Scientific and Technical Information of China (English)

    XinYao; BaocunSun; WenluLi; HuaChen; ZhaoxiangYe; CuiWang

    2004-01-01

    OBJECTIVE To evaluate the diagnosis and treatment for primary renal malignant fibrous histiocytoma, a rare tumor arising from the kidney.METHODS The clinical and pathological data from 4 cases of malignant fibrous histiocytoma of the kidney detected in our hospital are described.One case of special interest involved a giant cell subtype, the first to be reported in the oncology literature. The clinicopathologic features and prognostic factors of this tumor were analysed and summarized after reviewing 55 documented cases in the English and Chinese literature.RESULTS A palpable mass (71.2%), emaciation (54.2%) and pain (54,2%) were common manifestations in renal MFH, Of all the cases, 51 were identified as a storiform-pleomorphic subtype by pathologists. Inconsideration of all the prognosis related factors, the residual tumor and high TNM stage predicted a shortened survival duration, but the symptom of a fever served as a better prognostic factor.CONCLUSION Malignant fibrous histiocytoma which arises from the kidney is a rare pathologic type, and possesses a high tendency towards local recurrence and distant metastasis. Despite the poor prognosis, early detection and radical surgery can prolong survival in selected cases.

  12. Collagen immunostains can distinguish capsular fibrous tissue from septal fibrosis and may help stage liver fibrosis.

    Science.gov (United States)

    Chen, Wei; Rock, Jonathan B; Yearsley, Martha M; Hanje, A James; Frankel, Wendy L

    2014-01-01

    Core-needle biopsy remains essential for diagnosis of cirrhosis; however, evaluation of fibrosis in such biopsies is often challenging due to the fragmented nature of cirrhotic liver specimens. It is also common to see portions of liver capsules present in the biopsy which adds to the diagnostic challenge. The distinction between capsular/subcapsular fibrous tissue and septal fibrosis is critical to avoid potential overstaging of liver fibrosis. We compared the differential immunostaining in liver capsular and septal areas for collagens III, IV, V, VI, vitronectin, laminin, Orcein, and Trichrome in 15 whole sections of explanted cirrhotic livers and 5 simulated liver biopsies. Collagens III, IV, V, VI, Trichrome, and Orcein show distinct staining patterns in capsular fibrous tissue and septal fibrosis. Collagen IV shows strong diffuse septal staining and consistently weak to negative capsular staining. Collagens III and VI stain similar to IV for septal fibrosis, whereas collagen V, Trichrome, and Orcein show strong staining in both areas. Collagen IV, possibly with III or VI in addition to the routine Trichrome and hematoxylin and eosin stain, is useful in differentiating capsular fibrous tissue from septal fibrosis on challenging and fragmented liver biopsies.

  13. Controlled antiseptic/eosin release from chitosan-based hydrogel modified fibrous substrates.

    Science.gov (United States)

    Romano, Ilaria; Ayadi, Farouk; Rizzello, Loris; Summa, Maria; Bertorelli, Rosalia; Pompa, Pier Paolo; Brandi, Fernando; Bayer, Ilker S; Athanassiou, Athanassia

    2015-10-20

    Fibers of cellulose networks were stably coated with N-methacrylate glycol chitosan (MGC) shells using subsequent steps of dip coating and photo-curing. The photo-crosslinked MGC-coated cellulose networks preserved their fibrous structure. A model hydrophilic antiseptic solution containing eosin, chloroxylenol and propylene glycol was incorporated into the shells to study the drug release dynamics. Detailed drug release mechanism into phosphate buffered saline (PBS) solutions from coated and pristine fibers loaded with the antiseptic was investigated. The results show that the MGC-coated cellulose fibers enable the controlled gradual release of the drug for four days, as opposed to fast, instantaneous release from eosin coated pristine fibers. This release behavior was found to affect the antibacterial efficiency of the fibrous cellulose sheets significantly against Staphylococcus aureus and Candida albicans. In the case of the MGC-eosin functionalized system the antibacterial efficiency was as high as 85% and 90%, respectively, while for the eosin coated pristine cellulose system the efficiency was negative, indicating bacterial proliferation. Furthermore, the MGC-eosin system was shown to be efficacious in a model of wound healing in mice, reducing the levels of various pro-inflammatory cytokines that modulate early inflammatory phase responses. The results demonstrate good potential of these coated fibers for wound dressing and healing applications. Due to its easy application on common passive commercial fibrous dressings such as gauzes and cotton fibers, the method can render them active dressings in a cost effective way.

  14. Diode laser surgery versus scalpel surgery in the treatment of fibrous hyperplasia: a randomized clinical trial.

    Science.gov (United States)

    Amaral, M B F; de Ávila, J M S; Abreu, M H G; Mesquita, R A

    2015-11-01

    Fibrous hyperplasia is treated by surgical incision using a scalpel, together with removal of the source of chronic trauma. However, scalpel techniques do not provide the haemostasis that is necessary when dealing with highly vascular tissues. Diode laser surgery can be used in the management of oral tissues due to its high absorption by water and haemoglobin, and has provided good results in both periodontal surgery and oral lesions. The aim of the present study was to compare the effects of diode laser surgery to those of the conventional technique in patients with fibrous hyperplasia. A randomized clinical trial was performed in which surgical and postoperative evaluations were analyzed. On comparison of the laser-treated (study group) patients to those treated with a scalpel (control group), significant differences were observed in the duration of surgery and the use of analgesic medications. Over a 3-week period, clinical healing of the postoperative wound was significantly faster in the control group as compared to the study group. In conclusion, diode laser surgery proved to be more effective and less invasive when compared to scalpel surgery in the management of fibrous hyperplasia. However, wound healing proved to be faster when using scalpel surgery.

  15. Micro-poromechanics model of fluid-saturated chemically active fibrous media.

    Science.gov (United States)

    Misra, Anil; Parthasarathy, Ranganathan; Singh, Viraj; Spencer, Paulette

    2015-02-01

    We have developed a micromechanics based model for chemically active saturated fibrous media that incorporates fiber network microstructure, chemical potential driven fluid flow, and micro-poromechanics. The stress-strain relationship of the dry fibrous media is first obtained by considering the fiber behavior. The constitutive relationships applicable to saturated media are then derived in the poromechanics framework using Hill's volume averaging. The advantage of this approach is that the resultant continuum model accounts for the discrete nature of the individual fibers while retaining a form suitable for porous materials. As a result, the model is able to predict the influence of micro-scale phenomena, such as the fiber pre-strain caused by osmotic effects and evolution of fiber network structure with loading, on the overall behavior and in particular, on the poromechanics parameters. Additionally, the model can describe fluid-flow related rate-dependent behavior under confined and unconfined conditions and varying chemical environments. The significance of the approach is demonstrated by simulating unconfined drained monotonic uniaxial compression under different surrounding fluid bath molarity, and fluid-flow related creep and relaxation at different loading-levels and different surrounding fluid bath molarity. The model predictions conform to the experimental observations for saturated soft fibrous materials. The method can potentially be extended to other porous materials such as bone, clays, foams and concrete.

  16. Bionic electrospun ultrafine fibrous poly(L-lactic acid) scaffolds with a multi-scale structure

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Kai; Wang Xuefen; Jing Dazheng; Yang Yin; Zhu Meifang, E-mail: wangxf@dhu.edu.c [State Key Lab for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai, 201620 (China)

    2009-06-15

    Poly(L-lactic acid) (PLLA) tissue engineering scaffolds with porous inner structures of individual fibers and controllable architectures were successfully fabricated from the homogeneous polymer-solvent-nonsolvent system (PLLA, CH{sub 2}Cl{sub 2} and DMF) by a single capillary electrospinning with certain conductive patterned templates as fiber collectors. PLLA was dissolved in dimethylformamide (DMF) and methylene chloride (CH{sub 2}Cl{sub 2}) mixed solvent with different ratios. Semi-hollow fiber with porous inner structure and compact shell wall was formed by controlling the content of DMF in the mixed solvents. It is believed that the phase separation should be the key origin for the formation of this microstructure. In order to mimic the natural extracellular matrix (ECM) with a specific structure, conductive patterned collectors were designed and employed to manufacture PLLA ultrafine fibrous scaffolds with three-dimensional architectures. We believe these kinds of multi-scale biodegradable fibrous scaffolds with specific microstructure and macro-architectures could make the electrospun fibrous scaffold better mimic the natural extracellular matrix to satisfy tissue engineering.

  17. Bionic electrospun ultrafine fibrous poly(L-lactic acid) scaffolds with a multi-scale structure.

    Science.gov (United States)

    Zhang, Kai; Wang, Xuefen; Jing, Dazheng; Yang, Yin; Zhu, Meifang

    2009-06-01

    Poly(L-lactic acid) (PLLA) tissue engineering scaffolds with porous inner structures of individual fibers and controllable architectures were successfully fabricated from the homogeneous polymer-solvent-nonsolvent system (PLLA, CH(2)Cl(2) and DMF) by a single capillary electrospinning with certain conductive patterned templates as fiber collectors. PLLA was dissolved in dimethylformamide (DMF) and methylene chloride (CH(2)Cl(2)) mixed solvent with different ratios. Semi-hollow fiber with porous inner structure and compact shell wall was formed by controlling the content of DMF in the mixed solvents. It is believed that the phase separation should be the key origin for the formation of this microstructure. In order to mimic the natural extracellular matrix (ECM) with a specific structure, conductive patterned collectors were designed and employed to manufacture PLLA ultrafine fibrous scaffolds with three-dimensional architectures. We believe these kinds of multi-scale biodegradable fibrous scaffolds with specific microstructure and macro-architectures could make the electrospun fibrous scaffold better mimic the natural extracellular matrix to satisfy tissue engineering.

  18. Human aortic fibrolipid lesions. Progenitor lesions for fibrous plaques, exhibiting early formation of the cholesterol-rich core.

    OpenAIRE

    Bocan, T. M.; Guyton, J. R.

    1985-01-01

    The early development of the lipid-rich core and other features of atherosclerotic fibrous plaques has been elucidated by examining discrete, small regions of raised intima in human aorta, which often bear a resemblance to both fatty streaks and fibrous plaques. Approximately one-fourth of small raised lesions (less than 16 sq mm of surface area) contained little or no stainable lipid, while three-fourths had a characteristic appearance, which included a superficial layer of foam cells, a cor...

  19. Human aortic fibrolipid lesions. Progenitor lesions for fibrous plaques, exhibiting early formation of the cholesterol-rich core.

    OpenAIRE

    Bocan, T. M.; Guyton, J. R.

    1985-01-01

    The early development of the lipid-rich core and other features of atherosclerotic fibrous plaques has been elucidated by examining discrete, small regions of raised intima in human aorta, which often bear a resemblance to both fatty streaks and fibrous plaques. Approximately one-fourth of small raised lesions (less than 16 sq mm of surface area) contained little or no stainable lipid, while three-fourths had a characteristic appearance, which included a superficial layer of foam cells, a cor...

  20. Unexpected finding of elevated glucose uptake in fibrous dysplasia mimicking malignancy: contradicting metabolism and morphology in combined PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Stegger, Lars; Weckesser, Matthias [University Hospital of Muenster, Department of Nuclear Medicine (Germany); Juergens, Kai U.; Wormanns, Dag [University Hospital of Muenster, Department of Clinical Radiology (Germany); Kliesch, Sabine [University Hospital of Muenster, Department of Urology (Germany)

    2007-07-15

    Fibrous dysplasia is a common benign disorder of bone in which fibro-osseous tissue replaces bone spongiosa. Lesions have a typical appearance on computed tomography (CT) images and regularly show a markedly increased uptake in bone scintigraphy using {sup 99m}Tc-labelled methylene diphosphonate ({sup 99m}Tc-MDP) as radiotracer. The glucose avidity of these lesions depicted by positron emission tomography (PET) using the radiolabelled glucose derivative {sup 18}F-fluoro-2-deoxy-glucose (FDG) is less well known since FDG-PET does not have a role in the assessment of this disease. However, single cases have been reported in which fibrous dysplasia was present in patients undergoing FDG-PET scanning for oncological reasons, and no significant FDG uptake was observed for lesions identified as fibrous dysplasia. We report on a 24-year-old man with known fibrous dysplasia who underwent combined FDG-PET/CT scanning because of suspected recurrence of testicular cancer. In contrast to prior reports, a markedly elevated uptake of FDG was seen in numerous locations that were identified as fibrous dysplasia by CT. Based on this result, we conclude that fibrous dysplasia may mimick malignancy in FDG-PET and that coregistered CT may help to resolve these equivocal findings. (orig.)

  1. Simple synthesis of smart magnetically driven fibrous films for remote controllable oil removal

    Science.gov (United States)

    Wu, Jing; Wang, Nü; Zhao, Yong; Jiang, Lei

    2015-01-01

    Inspired by the marine mussel adhesive protein, smart, magnetically controllable, oil adsorption nanofibrous materials were successfully fabricated in this research. Taking advantage of the properties of dopamine whose molecular structure mimics the single unit of the marine mussel adhesive protein and can be polymerized in alkaline solution forming a ``glue'' layer on many kinds of material surfaces, magnetic iron(ii, iii) oxide (Fe3O4) nanoparticles were easily and robustly anchored on to electrospun poly(vinylidene fluoride) fibrous films. After fluorination, the as-prepared hierarchical structured films exhibited superhydrophobicity, superoleophilicity and an excellent oil adsorption capacity from water. Importantly, because of the magnetically controllable property endowed by the Fe3O4 nanoparticles, such fibrous films act as a ``smart magnetically controlled oil removal carrier'', which effectively overcome the drawbacks of other in situ oil adsorbant materials and can also be easily recovered. This work provides a simple strategy to fabricate magnetic responsive intelligent oil removal materials, which will find broad applications in complex environment oil-water separation.Inspired by the marine mussel adhesive protein, smart, magnetically controllable, oil adsorption nanofibrous materials were successfully fabricated in this research. Taking advantage of the properties of dopamine whose molecular structure mimics the single unit of the marine mussel adhesive protein and can be polymerized in alkaline solution forming a ``glue'' layer on many kinds of material surfaces, magnetic iron(ii, iii) oxide (Fe3O4) nanoparticles were easily and robustly anchored on to electrospun poly(vinylidene fluoride) fibrous films. After fluorination, the as-prepared hierarchical structured films exhibited superhydrophobicity, superoleophilicity and an excellent oil adsorption capacity from water. Importantly, because of the magnetically controllable property endowed by the Fe3

  2. Environmental controls for the precipitation of different fibrous calcite cement fabrics

    Science.gov (United States)

    Ritter, Ann-Christine; Wiethoff, Felix; Neuser, Rolf D.; Richter, Detlev K.; Immenhauser, Adrian

    2016-04-01

    Abiogenic calcite cements are widely used as climate archives. They can yield information on environmental change and climate dynamics at the time when the sediment was lithified in a (marine) diagenetic environment. Radiaxial-fibrous (RFC) and fascicular-optic fibrous (FOFC) calcite cements are two very common and similar pore-filling cement fabrics in Palaeozoic and Mesozoic carbonate rocks (Richter et al., 2011) and in Holocene Mg-calcitic speleothems (Richter et al., 2015). Both fabrics are characterised by distinct crystallographic properties. Current research has shown that these fabrics are often underexplored and that a careful combination of conservative and innovative proxies allows for a better applicability of these carbonate archives to paleoenvironmental reconstructions (Ritter et al., 2015). A main uncertainty in this context is that it is still poorly understood which parameters lead to the formation of either RFC or FOFC and if differential crystallographic parameters affect proxy data from these fabrics. This study aims at a better understanding of the environmental factors that may control either RFC or FOFC precipitation. Therefore, suitable samples (a stalagmite and a Triassic marine cement succession), each with clearly differentiable layers of RFC and FOFC, were identified and analysed in high detail using a multi-proxy approach. Detailed thin section and cathodoluminescence analysis of the samples allowed for a precise identification of layers consisting solely of either RFC or FOFC. Isotopic (δ13C, δ18O) as well as trace elemental compositions have been determined and the comparison of data obtained from these different carbonate archives sheds light on changes in environmental parameters during RFC or FOFC precipitation. References: Richter, D.K., et al., 2011. Radiaxial-fibrous calcites: A new look at an old problem. Sedimentary Geology, 239, 26-36 Richter, D.K., et al., 2015. Radiaxial-fibrous and fascicular-optic Mg-calcitic cave

  3. Characterization of fracture behavior of human atherosclerotic fibrous caps using a miniature single edge notched tensile test.

    Science.gov (United States)

    Davis, Lindsey A; Stewart, Samantha E; Carsten, Christopher G; Snyder, Bruce A; Sutton, Michael A; Lessner, Susan M

    2016-10-01

    One well-established cause of ischemic stroke is atherosclerotic plaque rupture in the carotid artery. Rupture occurs when a tear in the fibrous cap exposes highly thrombogenic material in the lipid core. Though some fibrous cap material properties have been measured, such as ultimate tensile strength and stress-strain responses, there has been very little, if any, data published regarding the fracture behavior of atherosclerotic fibrous caps. This study aims to characterize the qualitative and quantitative fracture behavior of human atherosclerotic plaque tissue obtained from carotid endarterectomy samples using two different metrics. Uniaxial tensile experiments along with miniature single edge notched tensile (MSENT) experiments were performed on strips of isolated fibrous cap. Crack tip opening displacement (CTOD) and stress in the un-cracked segment (UCS) were measured at failure in fibrous cap MSENT specimens subjected to uniaxial tensile loading. Both CTOD and the degree of crack blunting, measured as the radius of curvature of the crack tip, increased as tearing propagated through the tissue. Higher initial stress in the UCS is significantly correlated with higher collagen content and lower macrophage content in the fibrous cap (ρ=0.77, P=0.009; ρ=-0.64, P=0.047; respectively). Trends in the data show that higher CTOD is inversely related to collagen content, though the sample size in this study is insufficient to statistically substantiate this relationship. To the authors' knowledge, this is the pioneering study examining the fracture behavior of fibrous caps and the first use of the CTOD metric in vascular tissue. A tear in the fibrous cap of atherosclerotic plaque can lead to ischemic stroke or myocardial infarction. While there is some information in the literature regarding quantitative measures of fibrous cap failure, there is little information regarding the behavior of the tissue during failure. This study examines the failure behavior of fibrous

  4. Heat transfer in Rockwool modelling and method of measurement. The effect of natural convection on heat transfer in fibrous materials

    Energy Technology Data Exchange (ETDEWEB)

    Dyrboel, Susanne

    1998-05-01

    Fibrous materials are some of the most widely used materials for thermal insulation. In this project the focus of interest has been on fibrous materials for building application. Interest in improving the thermal properties of insulation materials is increasing as legislation is being tightened to reduce the overall energy consumption. A knowledge of the individual heat transfer mechanisms - whereby heat is transferred within a particular material is an essential tool to improve continuously the thermal properties of the material. Heat is transferred in fibrous materials by four different transfer mechanisms: conduction through air, conduction through fibres, thermal radiation and convection. In a particular temperature range the conduction through air can be regarded as a constant, and conduction through fibres is an insignificant part of the total heat transfer. Radiation, however, constitutes 25-40% of the total heat transfer in light fibrous materials. In Denmark and a number of other countries convection in fibrous materials is considered as non-existent when calculating heat transmission as well as when designing building structures. Two heat transfer mechanisms have been the focus of the current project: radiation heat transfer and convection. The radiation analysis serves to develop a model that can be used in further work to gain a wider knowledge of the way in which the morphology of the fibrous material, i.e. fibre diameter distribution, fibre orientation distribution etc., influences the radiation heat transfer under different conditions. The convection investigation serves to examine whether considering convection as non-existent is a fair assumption to use in present and future building structures. The assumption applied in practically is that convection makes a notable difference only in very thick insulation, at external temperatures below -20 deg. C, and at very low densities. For large thickness dimensions the resulting heat transfer through the

  5. Fibrous Platinum-Group Minerals in “Floating Chromitites” from the Loma Larga Ni-Laterite Deposit, Dominican Republic

    Directory of Open Access Journals (Sweden)

    Thomas Aiglsperger

    2016-11-01

    Full Text Available This contribution reports on the observation of enigmatic fibrous platinum-group minerals (PGM found within a chromitite body included in limonite (“floating chromitite” from Ni-laterites in the Dominican Republic. Fibrous PGM have a Ru-Os-Ir-Fe dominated composition and are characterized by fibrous textures explained by grain-forming fibers which are significantly longer (1–5 µm than they are wide (~100 nm. Back-scattered electron (BSE images suggest that these nanofibers are platinum-group elements (PGE-bearing and form <5 µm thick layers of bundles which are oriented orthogonal to grains’ surfaces. Trace amounts of Si are most likely associated with PGE-bearing nanofibers. One characteristic fibrous PGM was studied in detail: XRD analyses point to ruthenian hexaferrum. However, the unpolished fibrous PGM shows numerous complex textures on its surface which are suggestive for neoformation processes: (i features suggesting growth of PGE-bearing nanofibers; (ii occurrence of PGM nanoparticles within film material (biofilm? associated with PGE-bearing nanofibers; (iii a Si-rich and crater-like texture hosting PGM nanoparticles and an Ir-rich accumulation of irregular shape; (iv complex PGM nanoparticles with ragged morphologies, resembling sponge spicules and (v oval forms (<1 µm in diameter with included PGM nanoparticles, similar to those observed in experiments with PGE-reducing bacteria. Fibrous PGM found in the limonite may have formed due to supergene (bio-weathering of fibrous Mg-silicates which were incorporated into desulphurized laurite during stages of serpentinization.

  6. Fibrous Dysplasia

    Science.gov (United States)

    ... Size | S S M M L L Bone Basics Osteoporosis Osteogenesis Imperfecta Paget’s Disease of Bone Related Topics News Glossary ... focus(); */ } //--> Print-Friendly Page Home Bone Basics Osteoporosis Osteogenesis Imperfecta Paget’s Disease of Bone Related Topics About Us ...

  7. Fibrous hamartoma of infancy in the hand: unusual location and MR imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Song, You Seon; Lee, In Sook [Pusan National University School of Medicine, Department of Radiology, Busan (Korea); Pusan National University School of Medicine, Medical Research Institute, Busan (Korea); Kim, Hui Taek [Pusan National University Hospital, Department of Orthopaedic Surgery, Busan (Korea); Choi, Kyung-Un [Pusan National University School of Medicine, Medical Research Institute, Busan (Korea); Pusan National University Hospital, Department of Pathology, Busan (Korea); Song, Jong Woon [Inje University Pusan Paik Hospital, Department of Radiology, Busan (Korea)

    2010-10-15

    Fibrous hamartomas of infancy (FHIs) are benign, poorly-circumscribed, soft tissue growths presenting during the first 2 years of life and characteristically affecting the axilla, upper arm, upper trunk, inguinal region, and external genital area. Involvement of the hands and feet is extremely rare. We report a case of FHI unusually occurring in a deep portion of the hand. MRI revealed atypical features similar to that of a vascular malformation, hemangioma, fibromatosis, or neurofibromatosis of the hand. Partial resection of the mass was performed to correct the contracture of the second finger and an additional operation was not performed because of the benign nature of FHIs. (orig.)

  8. Ewing's sarcoma of the humerus mimicking fibrous dysplasia on imaging and biological behavior

    Energy Technology Data Exchange (ETDEWEB)

    Sundaram, Murali [Mayo Clinic, Department of Radiology, Rochester, Minnesota (United States); Cleveland Clinic, Diagnostic Radiology, Cleveland (United States); Inwards, Carrie Y. [Mayo Clinic, Department of Surgical Pathology, Rochester, Minnesota (United States); Shives, Thomas E. [Mayo Clinic, Department of Orthopedic Surgery, Rochester, Minnesota (United States); Anderson, Peter M. [Mayo Clinic, Department of Pediatric and Adolescent Medicine and Internal Medicine, Rochester, Minnesota (United States)

    2005-05-01

    We present the case of a 12-year-old girl who presented with a pathological fracture through a benign-appearing osteolytic lesion that was presumed to represent fibrous dysplasia. The fracture healed, and over the next 2.5 years there was further refracturing and healing with progressive osteolysis. A biopsy was performed and revealed Ewing's sarcoma. The disease was locally controlled by neoadjuvant chemotherapy and radiation therapy. The patient is disease free with excellent function 6 years following the discovery of the lesion. We illustrate and discuss the sequence of events. (orig.)

  9. Spontaneous Interlobar Pneumothorax in a Localized Fibrous Tumor of in the Pleura

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Tong [Dept. of Radiology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan (Korea, Republic of)

    2012-03-15

    We report a case of a localized fibrous tumor of in the pleura pleura; this tumor was associated with interlobar pneumothorax, which, to our knowledge, has not been reported to date. A 63-year-old woman presented with an incidentally-detected nodule, which was seen on her chest radiograph. It presented as a mural nodule within a cystic lesion, on the chest radiograph and axial CT, and a reformatted sagittal CT image could then be diagnosed as a pleural tumor associated with interlobar pneumothorax.

  10. Fibrous nano-silica (KCC-1)-supported palladium catalyst: Suzuki coupling reactions under sustainable conditions

    KAUST Repository

    Fihri, Aziz

    2011-11-15

    Noble amines recycled: Fibrous high-surface-area nano-silica functionalized with aminopropyl groups and loaded with well-dispersed Pd nanoparticles is evaluated for the Suzuki coupling of aromatic halides. It is active for the reaction of a range of aryl bromides and iodides as well as chlorides with aryl boronic acids in good to excellent yields. The catalyst can be recovered and reused for a number of cycles with negligible loss in activity. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Bone and gallium scan findings in malignant fibrous histiocytoma. Case report with radiographic and pathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Mackey, J.K.; Alexieva-Jackson, B.; Fetters, D.V.; Edwards, S.M.; McBride, J.P.; Cole, R.L.; Trapp, W.G.

    1987-01-01

    Malignant fibrous histiocytoma (MFH) is the most common soft tissue malignancy in adults. The Ga-67 citrate scan findings of an extremity-located MFH, the most common location of this neoplasm, have never been published in English language journals to the best of the authors' knowledge. Ga-67 citrate and Tc-99m MDP scans of the thigh mass accurately depicted the tumor's local extent, including the presence of central ischemic necrosis within the tumor, and the absence of adjacent osseous involvement and distant metastases, as correlated with computed tomography, angiography, and pathologic examinations.

  12. Electrochemical Tailoring of Fibrous Polyaniline and Electroless Decoration with Gold and Platinum Nanoparticles.

    Science.gov (United States)

    Abdelhamid, Muhammad E; Snook, Graeme A; O'Mullane, Anthony P

    2016-09-06

    Presented in this work is a facile and quick electrochemical method for controlling the morphology of thick polyaniline (PANi) films, without the use of templates. By stepping the polymerization potential from high voltages to a lower (or series of lower) voltage(s), we successfully controlled the morphology of the polymer, and fibrous structures, unique to each potential step, were achieved. In addition, the resultant film was tested electrochemically for its viability as an electrode material for flexible batteries and supercapacitors. Furthermore, the PANi film was decorated with gold and platinum nanoparticles via an electroless deposition process for possible electrocatalytic applications, whereby the oxidation of hydrazine at the composite was investigated.

  13. Huge solitary fibrous tumor of the pleura with hypoglycemia and hypokalemia: a case report.

    Science.gov (United States)

    Li, Zhi; Wang, Jun; Zhu, Quan; Li, Hai; Chen, Yijiang; Chen, Liang

    2014-01-01

    The occurrence of hypoglycemia with an intrathoracic tumor is referred to as Doege- Potter syndrome (DPS). However, the association between hypokalemia and DPS is rare. We report a case of a solitary fibrous tumor of the pleura with refractory hypoglycemia and hypokalemia. A 57-year-old male was admitted to our hospital for unconsciousness. His serum glucose and potassium levels were low. Radiological findings revealed a large tumor occupying the left hemithorax. Despite being treated with glucose and potassium replacement therapy, the patient still suffered from repetitive fasting hypoglycemic and hypokalemia episodes. After the tumor was completely resected, his serum levels of glucose and potassium returned to normal level.

  14. Gold Nanoparticles Supported on Fibrous Silica Nanospheres (KCC-1) as Efficient Heterogeneous Catalysts for CO Oxidation

    KAUST Repository

    Qureshi, Ziyauddin S.

    2016-04-13

    Gold nanoparticles (Au NPs) of different sizes were supported on fibrous silica nanospheres (KCC-1) by various methods. The size and the location of the Au NPs on the support were found to depend on the preparation method. The KCC-1-supported Au NPs were thoroughly characterized by using HR-TEM, XRD, X-ray photoelectron spectroscopy, UV, and Brunauer-Emmett-Teller surface area measurements and were applied in catalysis for the oxidation of CO. The catalytic performance is discussed in relation to the morphological properties of KCC-1. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Soft Tissue Paraspinal Inflammatory Malignant Fibrous Histiocytoma Presenting as a Lumbar Abscess

    Directory of Open Access Journals (Sweden)

    Emmanouil Liarmakopoulos

    2011-07-01

    Full Text Available The rarest subtype of malignant fibrous histiocytoma (MFH is the inflammatory type, which due to its peculiar clinical presentation may mimic an infectious process such as an abscess. The rarity of this disease and the unique features of its presentation may mislead the surgeon with consequent catastrophic results for the patient. In this study, a case report of a 65-year-old female patient with a soft-tissue inflammatory MFH presenting as a lumbar abscess and a review of the current literature are presented.

  16. Three-dimensional thermo-structural analysis of multidirectional fibrous composite plates

    Science.gov (United States)

    Mukherjee, Nilanjan; Sinha, P. K.

    A set of simple thermo-elastic constitutive relations are developed for a general n-directional fibrous composite. A typical multidirectional unit cell is assumed to consist of several unidirectional composite blocks. Transformation-based relationships are used to generate the thermo-elastic properties for the n-directional composite. The present material model is next used to analyze the thermostructural problem employing the finite element method. A quadratic isoparametric brick element is used to discretize both the thermal and structural fields. The material model is validated against an existing ideological model based on the laminate theory. Results reveal the effects of fibre directionality on several thermostructural parameters.

  17. Kinematics of fibrous vein growth: insights from stable isotopes and trace element data

    Science.gov (United States)

    Fischer, M. P.; Lefticariu, L.; Romanek, C.; Perry, E. C.

    2005-12-01

    Veins are important recorders of thermal, hydrological, structural, and geochemical conditions during deformation. Fibrous or bladed veins are particularly useful, because the mineral fibers are believed to grow continuously or episodically over what may be a significant geologic time period. Thus, individual mineral fibers document the complex, dynamic changes occurring coeval with vein growth and mineral precipitation. Geochemical and structural analyses have been used to constrain the kinematic history of a bed-parallel fibrous calcite vein from the Upper Jurassic La Casita Formation, Sierra Madre Oriental, Mexico. The La Casita Formation, correlative with the Smackover Formation of the northern US Gulf Coast, consists of shale and is part of a sedimentary succession that unconformably overlies evaporites of the Minas Viejas Formation. The fibrous vein examined in this study was taken from the backlimb of the frontal fold of the Monterrey salient near Saltillo. Optical petrographic observation reveals that the calcite fibers have blade or tapering lath shapes with widths from 0.1-1.0 mm. Other minerals present in the vein are pyrite, gypsum, bitumen, and iron oxides. High-resolution, closely spaced stable isotope and elemental analyses were carried out along five traverses across the vein width. The d18O values vary in a narrow range, with an average value of +20.8 permil (VSMOW). The d13C values increase systematically along the fibers, from the walls of the vein toward the suture plane. In all five traverses, the d13C increase is relatively constant, with lower values next to the vein wall (+1.2 to +1.6 permil PDB) and higher values along the suture line (+3.6 to +4.1 permil PDB). The vein minerals, fibrous calcite and accessory pyrite, are interpreted to be the products of high temperature reactions between light hydrocarbons and dissolved sulfate, known as thermochemical sulfate reduction (TSR). Reactants such as light hydrocarbons and products such as CO2

  18. Quantitative modelling of viscoelasticity of isotropic fibrous composites with viscoelastic matrices

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Despite the wide usage of isotropic fibrous composites with a viscoelastic polymer matrix,no analytic model for their mechanical behaviour is known.This paper develops such a model for time-dependent Young's modulus,showing that for typical constituents the time constants of composites are up to about 6% greater than the matrix shear time constant.Viscoelasticity is strongly suppressed for stiff fibres even at modest fibre volume fractions.Comparison with known results for particle and oriented fibre compos...

  19. Endoscopic Management in Fibrous Dysplasia of Ethmoid Sinus: One Case Report and Literatures Review

    Institute of Scientific and Technical Information of China (English)

    Zhaowei Gu; Zhiwei Cao; Yunxiu Wang

    2009-01-01

    @@ Introduction Fibrous dysplasia(FD)is a sporadic skeletal disorder in which normal bone structures and marrow are replaced by fibro-osseous tissue[1].It is classified into three types:monostotic FD,polyostotic FD,and McCune-Albright syndrome[2].The monostotic iS the most commen form of FD.The disease primarily affects the long bones of the patients,and may also develop in the craniofacial region.However,FD in the paranasal sinuses is uncommon.The case in this report was diagnosed as FD in the ethmoid sinus which is a rarely seen case.

  20. Flows induced by sorption on fibrous material in a two-layer oil-water system

    Science.gov (United States)

    Chaplina, T. O.; Chashechkin, Yu. D.; Stepanova, E. V.

    2016-09-01

    The processes of sorption on fibrous materials in the open elliptic cell filled with a two-layer oil-water liquid at rest are investigated experimentally. When the sorption efficiency dependent on the type of material proves to be reasonably high, large-scale flows are formed in the liquid. In this case, the uniformity of distribution of oil is violated and the free surface of the water is partially restored. The trajectories of motion of individual oil droplets on a released water surface are tracked, and the transfer rates are calculated in various phases of the process.

  1. BIRTH INJURY RELATED UNILATERAL ANTERIOR NARES PARTIAL FIBROUS ATRESIA: A RARE CASE REPORT

    Directory of Open Access Journals (Sweden)

    Jayagar

    2016-02-01

    Full Text Available Congenital atresia of anterior nares has been rarely reported and it may co-exist along with posterior choanal atresia. (1,2 In our case, birth injury caused by forceps delivery has caused unilateral anterior nares partial atresia. Twenty eight years old male patient came with the complaints of left nostril blocked sensation since birth, aggravated with attacks of upper respiratory tract infections. On examination he had left anterior nares partial atresia caused by fibrous bands as a result of birth injury due to instrumental delivery. Rhinoplasty performed to open-up left nostril and patient relieved of his symptoms and also on cosmetic appearance

  2. Obstructive jaundice caused by secondary pancreatic tumor from malignant solitary fibrous tumor of pleura: A case report

    Institute of Scientific and Technical Information of China (English)

    Norie Yamada; Hiroshi Yotsuyanagi; Michihiro Suzuki; Fumio Itoh; Chiaki Okuse; Masahito Nomoto; Mayu Orita; Yoshiki Katakura; Toshiya Ishii; Takuo Shinmyo; Hiroaki Osada; Ichiro Maeda

    2006-01-01

    A 77-year-old man on systemic chemotherapy against postoperative bilateral multiple lung metastases of malignant solitary fibrous tumor of the pleura suffered from pruritus and jaundice. Blood examination showed elevated levels of hepatobiliary enzymes. Abdominal computed tomography showed a tumor with peripheral enhancement in the pancreatic head, accompanied with the dilatation of intra- and extra-hepatic bile ducts. He was diagnosed as having obstructive jaundice caused by a pancreatic head tumor. The pancreatic head tumor was presumably diagnosed as the metastasis of malignant solitary fibrous tumor of the pleura, because the findings on the pancreatic head tumor on abdominal CT were similar to those on the primary lung lesion of malignant solitary fibrous tumor of the pleura. The pancreatic tumor grew rapidly after the implantation of metallic stent in the inferior part of the common bile duct. The patient died of lymphangitis carcinomatosa of the lungs. Autopsy revealed a tumor that spread from the pancreatic head to the hepatic hilum. Microscopically, spindle-shaped cells exhibiting nuclear atypicality or division together with collagen deposition were observed. Immunohistochemically the pancreatic head tumor cells were negative for staining of α-smooth muscle actin (α-SMA) or CD117, but positive for vimentin, CD34 and CD99. These findings are consistent with thoseon malignant solitary fibrous tumor of the pleura. We report the first case of obstructive jaundice caused by a secondary pancreatic tumor from malignant solitary fibrous tumor of the pleura.

  3. Tubing-Electrospinning: A One-Step Process for Fabricating Fibrous Matrices with Spatial, Chemical, and Mechanical Gradients.

    Science.gov (United States)

    Kim, Jung-Suk; Im, Byung Gee; Jin, Gyuhyung; Jang, Jae-Hyung

    2016-08-31

    Guiding newly generated tissues in a gradient pattern, thereby precisely mimicking inherent tissue morphology and subsequently arranging the intimate networks between adjacent tissues, is essential to raise the technical levels of tissue engineering and facilitate its transition into the clinic. In this study, a straightforward electrospinning method (the tubing-electrospinning technique) was developed to create fibrous matrices readily with diverse gradient patterns and to induce patterned cellular responses. Gradient fibrous matrices can be produced simply by installing a series of polymer-containing lengths of tubing into an electrospinning circuit and sequentially processing polymers without a time lag. The loading of polymer samples with different characteristics, including concentration, wettability, and mechanical properties, into the tubing system enabled unique features in fibrous matrices, such as longitudinal gradients in fiber density, surface properties, and mechanical stiffness. The resulting fibrous gradients were shown to arrange cellular migration and residence in a gradient manner, thereby offering efficient cues to mediate patterned tissue formation. The one-step process using tubing-electrospinning apparatus can be used without significant modifications regardless of the type of fibrous gradient. Hence, the tubing-electrospinning system can serve as a platform that can be readily used by a wide-range of users to induce patterned tissue formation in a gradient manner, which will ultimately improve the functionality of tissue engineering scaffolds.

  4. Fibrous Support Stabilizes Nitrification Performance of a Membrane-Aerated Biofilm: The Effect of Liquid Flow Perturbation

    DEFF Research Database (Denmark)

    Terada, Akihiko; Ito, J; Matsumoto, S

    2009-01-01

    Nitrification stability and biofilm robustness were examined by comparing a fibrous support membrane-aerated biofilm reactor (FS-MABR), where a woven fibrous support was surrounded on a silicone tube, with an MABR. The overall mass transfer coefficient of oxygen for the FS-MABR, assuming no bound......Nitrification stability and biofilm robustness were examined by comparing a fibrous support membrane-aerated biofilm reactor (FS-MABR), where a woven fibrous support was surrounded on a silicone tube, with an MABR. The overall mass transfer coefficient of oxygen for the FS-MABR, assuming...... liquid flow rate condition was 49% and 75% in the FS-MABR and MABR, exhibiting robust biofilms grown on the fibrous support. The FS-MABR provided more stable nitrification performance than the MABR irrespective of a high liquid flow rate. Both reactors have deteriorated ammonium (NH4+-N) removal without...... a high liquid flow rate condition to eliminate excessive biomass, indicating that regular maintenance is essential to eliminate excessive biofilm from a MABR for nitrification, which potentially acts as a NH4+ diffusion barrier....

  5. Calcifying fibrous pseudotumor of pleura. A report of three cases of a newly described entity involving the pleura.

    Science.gov (United States)

    Pinkard, N B; Wilson, R W; Lawless, N; Dodd, L G; McAdams, H P; Koss, M N; Travis, W D

    1996-02-01

    A newly recognized distinctive fibrous soft tissue lesion called "calcifying fibrous pseudotumor" (CFPT) was recently described in the soft tissues of the extremities, trunk, scrotum, groin, neck, or axilla. To date, CFPT has not been described in the pleura. The authors reviewed the clinical, radiologic, and pathologic features of three cases. A 23-year old woman and 34-year old man who presented with chest pain, and a 28-year old woman without chest symptoms were found to have a pleural mass on chest radiographs. Computed tomography (CT) scans of each patient revealed pleural-based nodular masses with central areas of increased attenuation due to calcifications. Each lesions consisted of circumscribed, but unencapsulated masses of hyalinized collagenous fibrotic tissue interspersed with lymphoplasmacytic infiltrates and calcifications, many of which had psammomatous features. The lesions were limited to the pleura and did not involve the underlying lung parenchyma. Electron microscopy in one case showed fibroblasts scattered in dense collagenous tissue. Calcifying fibrous pseudotumor is distinct from other pleural lesions such as fibrous tumor of pleura, calcified granulomas, calcified pleural plaques, and chronic fibrous pleuritis as well as intrapulmonary lesions such as hyalinizing granuloma, inflammatory pseudotumor, and amyloid. As in the soft tissues, local excision appears adequate therapy for CFPT of the pleura. If these lesions behave in a similar fashion to CFPT of soft tissues, one might expect a low frequency of local recurrence.

  6. Extracranial metastasizing solitary fibrous tumors (SFT) of meninges: histopathological features of a case with long-term follow-up.

    Science.gov (United States)

    Gessi, Marco; Gielen, Gerrit H; Roeder-Geyer, Eva-Dorette; Sommer, Clemens; Vieth, Michael; Braun, Veit; Kuchelmeister, Klaus; Pietsch, Torsten

    2013-02-01

    Extrapleural solitary fibrous tumors are uncommon mesenchymal neoplasms frequently observed in middle-aged adults and are classified, according to the WHO classification of soft tissue tumors, as part of the hemangiopericytoma tumor group. However, these two entities remain separated in the WHO classification of tumors of the central nervous system. In fact, meningeal solitary fibrous tumors are believed to be benign lesion and only in a minority of cases local relapses have been described, although detailed survival clinical studies on solitary fibrous tumors of meninges are rare. In contrast to hemangiopericytoma, which frequently shows distant extracranial metastases, such an event is exceptional in patients with meningeal solitary fibrous tumors and has been clinically reported in a handful of cases only and their histopathological features have not been investigated in detail. In this report, we describe the detailed clinico-pathological features of a meningeal solitary fibrous tumor presenting during a 17-year follow-up period, multiple intra-, extracranial relapses and lung metastases.

  7. Displasia fibrosa do clivus: relato de caso Fibrous dysplasia of the clivus: case report

    Directory of Open Access Journals (Sweden)

    Asdrubal Falavigna

    2006-06-01

    Full Text Available Relatamos o caso de uma paciente de 43 anos com história de cefaléia crônica e diplopia. O exame neurorradiológico demonstrou aumento de volume e alteração na densidade óssea do clivus. Foi submetida a cirurgia e o exame anatomopatológico evidenciou displasia fibrosa. Foram relatados na literatura outros 14 casos de displasia fibrosa envolvendo o clivus. Discutimos essa rara apresentação da doença segundo o quadro clínico, exames de imagem, histologia e tratamento.We describe the case of a 43 year-old woman with chronic headache and diplopia. The neurorradiologic exam showed volume increase and alteration in the bone density of the clivus. She was submitted to surgery and the anatomopathologic evidenced fibrous dysplasia. Other 14 of about fibrous dysplasia involving the clivus are related in the literature. We discuss clinical aspects, image exams, histology and treatment of this rare presentation of the disease.

  8. Flexible electrodes based on polypyrrole/manganese dioxide/polypropylene fibrous membrane composite for supercapacitor

    Energy Technology Data Exchange (ETDEWEB)

    Jin Ming [Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Shanxi University, Taiyuan 030006 (China); Han Gaoyi, E-mail: han_gaoyis@sxu.edu.cn [Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Shanxi University, Taiyuan 030006 (China); Chang Yunzhen; Zhao Hua; Zhang Huanyu [Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Shanxi University, Taiyuan 030006 (China)

    2011-11-30

    Highlights: > PPy/MnO{sub 2}/polypropylene fibrous film (PPF) is prepared by polymerizing pyrrole in gas. > The morphology and conductivity are influenced strongly by the content of PPy/MnO{sub 2}. > Specific capacitance of the capacitor reaches 110 F g{sup -1} based on amount of PPy/MnO{sub 2}. - Abstract: The composites of polypyrrole/manganese dioxide/polypropylene fibrous films (PPy/MnO{sub 2}/PPF) have been prepared in situ through chemical oxidation polymerization by using the mixture of FeCl{sub 3}.6H{sub 2}O and MnO{sub 2} adsorbed on PPF as oxidant in the atmosphere of pyrrole vapor at room temperature. The morphologies and structures of the composites are investigated by using scanning electron microscope and X-ray diffraction spectroscopy. The properties of the capacitor cells assembled by the composites of PPy/MnO{sub 2}/PPF are evaluated by cyclic voltammetry, galvanostatic charge/discharge and electrochemical impedance spectroscopy methods. The results reveal that the morphologies, conductivities and capacitance performance of the composites are influenced strongly by the content of MnO{sub 2} in the solution of oxidant. The capacitors assembled by PPy/MnO{sub 2}/PPF exhibit the property of quick charge/discharge, and the highest specific capacitance of about 110 F g{sup -1} is obtained when the PPy/MnO{sub 2} content in the composite is about 17.4%.

  9. A RARE CASE OF SOLITARY FIBROUS TUMOUR OF THE PLUERA IN MANIPUR, INDIA

    Directory of Open Access Journals (Sweden)

    Debobratta

    2014-11-01

    Full Text Available Solitary fibrous tumor (SFT is uncommon soft tissue tumors which most frequently occur in the pleura. Most of these tumors project into the pleural cavity in a pedunculated manner from the visceral pleura. Larger tumors in the thoracic cavity may present with dyspnea, chest pain and malaise while smaller tumors are usually asymptomatic. Since its first description in 1931, only 800 cases of such tumors have been reported so far. Here we present a case of a 40 year old housewife with complaints of right sided, vague, dull-aching chest pain for 2 months. Her medical history was unremarkable. Radiologic imaging revealed a large (16.5cm X 10cm lobulated mass lesion seen in the right hemi-thorax. Right sided postero-lateral thoracotomy was done and the tumor was excised. Histo-patological examination of the cut section showed benign spindle cell tumor. Immunohistochemistry was positive for CD34. Solitary Fibrous Tumor of the pleura is a rare neoplasm and no such case has been reported so far from Manipur, India. We were successful in detecting; planning and complete surgical removal of the SFT of the pleura in our patient and the patient is under monitoring and follow up to detect any recurrence in near future.

  10. Mechanical Cell-Cell Communication in Fibrous Networks: The Importance of Network Geometry.

    Science.gov (United States)

    Humphries, D L; Grogan, J A; Gaffney, E A

    2017-03-01

    Cells contracting in extracellular matrix (ECM) can transmit stress over long distances, communicating their position and orientation to cells many tens of micrometres away. Such phenomena are not observed when cells are seeded on substrates with linear elastic properties, such as polyacrylamide (PA) gel. The ability for fibrous substrates to support far reaching stress and strain fields has implications for many physiological processes, while the mechanical properties of ECM are central to several pathological processes, including tumour invasion and fibrosis. Theoretical models have investigated the properties of ECM in a variety of network geometries. However, the effects of network architecture on mechanical cell-cell communication have received little attention. This work investigates the effects of geometry on network mechanics, and thus the ability for cells to communicate mechanically through different networks. Cell-derived displacement fields are quantified for various network geometries while controlling for network topology, cross-link density and micromechanical properties. We find that the heterogeneity of response, fibre alignment, and substrate displacement fields are sensitive to network choice. Further, we show that certain geometries support mechanical communication over longer distances than others. As such, we predict that the choice of network geometry is important in fundamental modelling of cell-cell interactions in fibrous substrates, as well as in experimental settings, where mechanical signalling at the cellular scale plays an important role. This work thus informs the construction of theoretical models for substrate mechanics and experimental explorations of mechanical cell-cell communication.

  11. Evaluation of effective thermal diffusivity and conductivity of fibrous materials through computational micromechanics

    Science.gov (United States)

    Ahmadi, Isa

    2017-01-01

    The aim of present study is to investigate the effective thermal properties of composite material via micromechanical modeling of the composite material as a heterogeneous material. These properties mainly include the thermal diffusivity and the thermal conductivity of composites. For this purpose, a definition is presented for effective thermal diffusivity for heterogeneous materials based on heat diffusion rate into the material in a transient heat transfer. A micromechanical model based on the Representative Volume Element (RVE) is presented for modeling the heat conduction in the fibrous composite materials. An appropriate heat transfer problem for the RVE is defined so that by the analogy of the numerical results the effective properties of the RVE can be estimated. A numerical method is employed to analyze the steady-state and transient heat flux and temperature in the RVE. To validate the model, the predictions of present model are compared with results of analytical method, FEM and some available experimental data in the open literature. The effective thermal conductivity and thermal diffusivity are then obtained for fibrous composites via the present micromechanical model. The SiC/Ti, SiC/Ti6%Al4%V and Glass/Epoxy composites with various fiber volume fractions are considered in this study.

  12. Aligned Fibrous Scaffold Induced Aligned Growth of Corneal Stroma Cells in vitro Culture

    Institute of Scientific and Technical Information of China (English)

    GAO Yan; YAN Jing; CUI Xue-jun; WANG Hong-yan; WANG Qing

    2012-01-01

    To investigate the contribution of fibre arrangement to guiding the aligned growth of corneal stroma cells,aligned and randomly oriented fibrous scaffolds of gelatin and poly-L-lactic acid(PLLA) were fabricated by electrospinning.A comparative study of two different systems with corneal stroma cells on randomly organized and aligned fibres were conducted.The efficiency of the scaffolds for inducing the aligned growth of cells was assessed by morphological observation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide(MTT) assay.Results show that the cells cultured on both randomly oriented and aligned scaffolds maintained normal morphology and well spreading as well as long term proliferation.Importantly,corneal stroma cells grew high orderly on the aligned scaffold,while the cells grew disordered on the randomly oriented scaffold.Moreover,the cells exhibited higher viability in aligned scaffold than that in randomly oriented scaffold.These results indcate that electrospinng to prepare aligned fibrous scaffolds has provided an effective approach to the aligned growth of corneal stroma cells in vitro.Our findings that fiber arrangement plays a crucial role in guiding the aligned growth of cells may be helpful to the development of better biomaterials for tissue engineered cornea.

  13. An In Vitro Investigation of Pulmonary Alveolar Macrophage Cytotoxicity Introduced by Fibrous and Grainy Mineral Dusts

    Institute of Scientific and Technical Information of China (English)

    DONG Faqin; DENG Jianjun; WU Fengchun; PU Xiaoyong; John HUANG; FENG Qiming; HE Xiaochun

    2006-01-01

    In order to study the damage mechanism of mineral dusts on the pulmonary alveolar macrophage (AM), the changes in their death ratio, malandialdthyde (MDA) content and activities of lactate dehydrogenase (LDH) and superoxide dismutase (SOD) were measured, and the technique of cell culture in vitro was used to investigate the cytotoxicity of six mineral dusts (twelve crystal habits)from twelve mineral deposits. The results show that wollastonite and clinoptilolite have no AM cytotoxicity, while other fibrous and grainy mineral dusts damage pulmonary AM in various degrees.The cytotoxicity of fibrous mineral dusts was greater than that of the grainy ones, and the cytotoxicity of dusts was positively correlated with the active OH- content in dusts, but not necessarily so with its SiO2 content. The high pH values produced by dust was unfavorable for the survival of cells and the dusts with low bio-resistance were safe for cells. The content of variable valence elements in dusts might influence their cytotoxicity and the surface charge of dusts was not a stable factor for their toxicity. It is demonstrated that the shape of mineral dusts was one of the factors affecting cytotoxicity, and that the cytotoxicity of mineral dusts depends mainly on their properties.

  14. Microphase Separation Controlled beta-Sheet Crystallization Kinetics in Fibrous Proteins

    Energy Technology Data Exchange (ETDEWEB)

    Hu, X.; Lu, Q; Kaplan, D; Cebe, P

    2009-01-01

    Silk is a naturally occurring fibrous protein with a multiblock chain architecture. As such, it has many similarities with synthetic block copolymers, including the possibility for e-sheet crystallization restricted within the crystallizable blocks. The mechanism of isothermal crystallization kinetics of e-sheet crystals in silk multiblock fibrous proteins is reported in this study. Kinetics theories, such as Avrami analysis which was established for studies of synthetic polymer crystal growth, are for the first time extended to investigate protein self-assembly in e-sheet rich Bombyx mori silk fibroin samples, using time-resolved Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and synchrotron real-time wide-angle X-ray scattering (WAXS). The Avrami exponent, n, was close to 2 for all methods and crystallization temperatures, indicating formation of e-sheet crystals in silk proteins is different from the 3-D spherulitic crystal growth found in synthetic polymers. Observations by scanning electron microscopy support the view that the protein structures vary during the different stages of crystal growth, and show a microphase separation pattern after chymotrypsin enzyme biodegradation. We present a model to explain the crystallization of the multiblock silk fibroin protein, by analogy to block copolymers: crystallization of e-sheets occurs under conditions of geometrical restriction caused by phase separation of the crystallizable and uncrystallizable blocks. This crystallization model could be widely applicable in other proteins with multiblock (i.e., crystallizable and noncrystallizable) domains.

  15. Roles of the Fibrous Superficial Zone in the Mechanical Behavior of TMJ Condylar Cartilage.

    Science.gov (United States)

    Ruggiero, Leonardo; Zimmerman, Brandon K; Park, Miri; Han, Lin; Wang, Liyun; Burris, David L; Lu, X Lucas

    2015-11-01

    In temporomandibular joints (TMJs), the cartilage on the condylar head displays a unique ultrastructure with a dense layer of type I collagen in the superficial zone, different from hyaline cartilage in other joints. This study aims to elucidate the roles of this fibrous zone in the mechanical behaviors, particularly lubrication, of TMJ under physiological loading regimes. Mechanical tests on porcine condylar cartilage demonstrated that the superficial and middle-deep zones exhibit tension-compression nonlinearity. The tensile and compressive moduli of the superficial zone are 30.73 ± 12.97 and 0.028 ± 0.016 MPa, respectively, while those for the middle-deep zone are 2.43 ± 1.75 and 0.14 ± 0.09 MPa. A nonlinear finite element model of condylar cartilage was built to simulate sliding of a spherical probe over the articular surface. The presence of the superficial zone significantly promoted interstitial fluid pressurization (IFP) inside the loaded cartilage and reduced the friction force on the surface, compared to the case without the superficial zone. Finite element simulations showed that IFP depends on sliding speed but not normal load, which matches the experimental results. This study revealed the presence of the fibrous zone can significantly reduce the deformation of condylar cartilage under compression and the friction force on its surface during sliding.

  16. Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?

    Science.gov (United States)

    Sanchez, Vanesa C; Pietruska, Jodie R; Miselis, Nathan R; Hurt, Robert H; Kane, Agnes B

    2009-01-01

    Human diseases associated with exposure to asbestos fibers include pleural fibrosis and plaques, pulmonary fibrosis (asbestosis), lung cancer, and diffuse malignant mesothelioma. The critical determinants of fiber bioactivity and toxicity include not only fiber dimensions, but also shape, surface reactivity, crystallinity, chemical composition, and presence of transition metals. Depending on their size and dimensions, inhaled fibers can penetrate the respiratory tract to the distal airways and into the alveolar spaces. Fibers can be cleared by several mechanisms, including the mucociliary escalator, engulfment, and removal by macrophages, or through splitting and chemical modification. Biopersistence of long asbestos fibers can lead to inflammation, granuloma formation, fibrosis, and cancer. Exposure to synthetic carbon nanomaterials, including carbon nanofibers and carbon nanotubes (CNTs), is considered a potential health hazard because of their physical similarities with asbestos fibers. Respiratory exposure to CNTs can produce an inflammatory response, diffuse interstitial fibrosis, and formation of fibrotic granulomas similar to that observed in asbestos-exposed animals and humans. Given the known cytotoxic and carcinogenic properties of asbestos fibers, toxicity of fibrous nanomaterials is a topic of intense study. The mechanisms of nanomaterial toxicity remain to be fully elucidated, but recent evidence suggests points of similarity with asbestos fibers, including a role for generation of reactive oxygen species, oxidative stress, and genotoxicity. Considering the rapid increase in production and use of fibrous nanomaterials, it is imperative to gain a thorough understanding of their biologic activity to avoid the human health catastrophe that has resulted from widespread use of asbestos fibers.

  17. Tailoring degradation of AZ31 alloy by surface pre-treatment and electrospun PCL fibrous coating

    Energy Technology Data Exchange (ETDEWEB)

    Hanas, T. [Medical Materials Laboratory, Indian Institute of Technology Madras, Chennai 600036 (India); School of Nano Science and Technology, National Institute of Technology Calicut, Calicut, Kerala 673601 (India); Sampath Kumar, T.S., E-mail: tssk@iitm.ac.in [Medical Materials Laboratory, Indian Institute of Technology Madras, Chennai 600036 (India); Perumal, Govindaraj; Doble, Mukesh [Department of Biotechnology - Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036 (India)

    2016-08-01

    AZ31 magnesium alloy was coated with polycaprolactone (PCL) nano-fibrous layer using electrospinning technique so as to control degradation in physiological environment. Before coating, the alloy was treated with HNO{sub 3} to have good adhesion between the coating and substrate. To elucidate the role of pre-treatment and coating, samples only with PCL coating as well as HNO{sub 3} treatment only were prepared for comparison. Best coating adhesion of 4B grade by ASTM D3359–09 tape test was observed for pre-treated samples. The effect of coating on in vitro degradation and biomineralization was studied using supersaturated simulated body fluid (SBF 5 ×). The weight loss and corrosion results obtained by immersion test showed that the combination of HNO{sub 3} pre-treatment and PCL coating is very effective in controlling the degradation rate and improving bioactivity. Cytotoxicity studies using L6 cells showed that PCL coated sample has better cell adhesion and proliferation compared to uncoated samples. Nano-fibrous PCL coating combined with prior acid treatment seems to be a promising method to tailor degradation rate with enhanced bioactivity of Mg alloys. - Highlights: • PCL electrospun coating on HNO{sub 3} pre-treated AZ31 alloy controls biodegradation. • Acid pre-treatment stabilizes the substrate - coating interface. • Electrospun porous coating improves biomineralization. • Coating similar to extracellular matrix enhances cell adhesion.

  18. Inverse Problem of Air Filtration of Nanoparticles: Optimal Quality Factors of Fibrous Filters

    Directory of Open Access Journals (Sweden)

    Dahua Shou

    2015-01-01

    Full Text Available Application of nanofibers has become an emerging approach to enhance filtration efficiency, but questions arise about the decrease in Quality factor (QF for certain particles due to the rapidly increasing pressure drop. In this paper, we theoretically investigate the QF of dual-layer filters for filtration of monodisperse and polydisperse nanoparticles. The inverse problem of air filtration, as defined in this work, consists in determining the optimal construction of the two-layer fibrous filter with the maximum QF. In comparison to a single-layer substrate, improved QF values for dual-layer filters are found when a second layer with proper structural parameters is added. The influences of solidity, fiber diameter, filter thickness, face velocity, and particle size on the optimization of QF are studied. The maximum QF values for realistic polydisperse particles with a lognormal size distribution are also found. Furthermore, we propose a modified QF (MQF accounting for the effects of energy cost and flow velocity, which are significant in certain operations. The optimal MQF of the dual-layer filter is found to be over twice that of the first layer. This work provides a quick tool for designing and optimizing fibrous structures with better performance for the air filtration of specific nanoparticles.

  19. Effect of fibrous filter properties on the oil-in-water-emulsion separation and filtration performance.

    Science.gov (United States)

    Bansal, Swarna; von Arnim, Volkmar; Stegmaier, Thomas; Planck, Heinrich

    2011-06-15

    Separation of secondary emulsions of dispersed droplet size less than 10 μm, by means of fibrous medium is a very complex but important process. The study investigates the influence of thin fibrous filter properties, i.e. surface energy, pore size and porosity on the separation performance of an isooctane in water emulsion (0.2%, mean drop size 2 μm). Experiments were carried out on five different filter media with a wide variation in their pore size (2-51 μm), surface energy (14-46 mN/m) and porosity (0.46-0.87) at similar process conditions. Filter media with different wettability are obtained by applying various hydrophobic and hydrophilic coatings. All the used coatings contain nanoparticles (25 nm) to impart nanoscale surface roughness at the single fiber surface. Besides emulsion properties and operating conditions, the phase separation mechanism and performance highly depends on pore size, surface energy and porosity of the filter media. More complete coalescence takes place at reduced pore size and at a surface preferentially wetted by the dispersed phase. Whereas when the pore size equals to the influent droplet size, then the surface wettability of filter is less effective and the separation mechanism is governed by inflow velocity. The emulsion inflow velocity and pressure drop are significantly affected by the filter media air permeability but do not depend on filter surface energy.

  20. Intradural Solitary Fibrous Tumor of the Lumbar Spine: A Distinctive Case Report

    Directory of Open Access Journals (Sweden)

    Recep Basaran

    2015-01-01

    Full Text Available Background. Solitary fibrous tumors are ubiquitous mesenchymal neoplasms of putative fibroblastic origin. They were originally described in the pleura but subsequently have been reported in many extraserosal sites. Solitary fibrous tumors may also occur in the meninges, central nervous system parenchyma, and spinal cord. Case. A 67-year-old male patient with progressive lower extremity weakness, urinary urgency, and sexual dysfunction has been admitted to our hospital. On his lumbar MRI, we detected an intradural lesion posterior to the L3 vertebral corpus. We resected the lesion by L3 total laminectomy. Immunohistological findings revealed strong and diffuse immunopositivity with vimentin, CD34, and bcl-2. Ki-67 proliferation index was 5–8%. We did not detect any recurrence 12 months after his operation. Conclusion. SFT is mostly seen in young and middle-aged patients and should be considered among differential diagnosis in cases suffering from pain, hypoesthesia, and urinary dysfunction. Gross total resection should be primary treatment. Tumors that have high Ki-67 labeling should be followed up for potential recurrences.

  1. Report of a Rare Case of Malignant Fibrous Histiocytoma of Mandible

    Directory of Open Access Journals (Sweden)

    Fatemeh Ahmadi-Motamayel

    Full Text Available Introduction: Malignent Fibrous Histiocytoma (MFH is the most frequent soft tissue sarcoma of adulthood. The most common sites affected by MFH are limbs, orbit, retroperitoneum, pelvis and knee. Oral cavity and mandible involvements are very rare. Case Report: A 35-year-old male was visited in the oral medicine department of Hamadan dental school with the chief complaint of pain and teeth mobility. The patient also had a history of paresthesia in lower lip for two monthes. In intraoral examination, there was a crater like, deep and disseminated ulcer in lower buccal and ligual gingiva of right mandibular teeth and exophitic lesion with smooth surface, and color similar to normal mucosa with 2×2×3 cm in diameter in buccal and lingual part of right lateral and central teeth extended to left second premolar was observed. Gingival resorption was observed in all adjascent teeth. There was radiolucency with irregular border in all part of lesion. MFH was confirmed by histopathological report.Conclusion: The most common complaint of patients with malignant fibrous histiocytoma is the growing mass that could be ulcerative or painful. Early diagnosis and referral is very important in prognosis and survival of the patients.

  2. Case Report of a Satin Guinea Pig with Fibrous Osteodystrophy That Resembles Human Pseudohypoparathyroidism

    Directory of Open Access Journals (Sweden)

    Miguel Gallego

    2017-01-01

    Full Text Available A case report of a 2-year-old female satin guinea pig with a history of dental overgrowth and lameness and radiological lesions of fibrous osteodystrophy is presented. The most relevant clinical findings were bone demineralization, high level of parathyroid hormone (PTH, normophosphatemia, normal ionized calcium, and low total thyroxine (tT4 with a normal renal function. Long-term treatment was based on teeth coronal reduction and maintaining a balanced diet. PTH measurement was performed with a kit suitable for rats to test 4 different paired samples of guinea pigs and resulted in similar results for each pair of measurements. Two kits routinely employed in dogs and cats failed in measuring PTH in guinea pig serum samples. The ionized calcium, PTH, and tT4 values, not previously reported in similar cases, were obtained. The determination of tT4 could be useful in the diagnosis of fibrous osteodystrophy in guinea pigs. The observed findings show similarity with human pseudohypoparathyroidism type Ia, a disease caused by an inactivating heterozygous mutation of the stimulatory G protein α subunit from the maternal genome that induces multiple hormone resistance and that courses with a syndrome called Albright hereditary osteodystrophy. Naturally occurring pseudohypoparathyroidism in animals has been reported previously only in a ferret.

  3. Continuum theory of fibrous tissue damage mechanics using bond kinetics: application to cartilage tissue engineering.

    Science.gov (United States)

    Nims, Robert J; Durney, Krista M; Cigan, Alexander D; Dusséaux, Antoine; Hung, Clark T; Ateshian, Gerard A

    2016-02-06

    This study presents a damage mechanics framework that employs observable state variables to describe damage in isotropic or anisotropic fibrous tissues. In this mixture theory framework, damage is tracked by the mass fraction of bonds that have broken. Anisotropic damage is subsumed in the assumption that multiple bond species may coexist in a material, each having its own damage behaviour. This approach recovers the classical damage mechanics formulation for isotropic materials, but does not appeal to a tensorial damage measure for anisotropic materials. In contrast with the classical approach, the use of observable state variables for damage allows direct comparison of model predictions to experimental damage measures, such as biochemical assays or Raman spectroscopy. Investigations of damage in discrete fibre distributions demonstrate that the resilience to damage increases with the number of fibre bundles; idealizing fibrous tissues using continuous fibre distribution models precludes the modelling of damage. This damage framework was used to test and validate the hypothesis that growth of cartilage constructs can lead to damage of the synthesized collagen matrix due to excessive swelling caused by synthesized glycosaminoglycans. Therefore, alternative strategies must be implemented in tissue engineering studies to prevent collagen damage during the growth process.

  4. Quantification of the fungal fraction released from various preloaded fibrous filters during a simulated ventilation restart.

    Science.gov (United States)

    Morisseau, K; Joubert, A; Le Coq, L; Andres, Y

    2017-05-01

    This study aimed to demonstrate that particles, especially those associated with fungi, could be released from fibrous filters used in the air-handling unit (AHU) of heating, ventilation and air-conditioning (HVAC) systems during ventilation restarts. Quantification of the water retention capacity and SEM pictures of the filters was used to show the potential for fungal proliferation in unused or preloaded filters. Five fibrous filters with various particle collection efficiencies were studied: classes G4, M5, M6, F7, and combined F7 according to European standard EN779:2012. Filters were clogged with micronized rice particles containing the fungus Penicillium chrysogenum and then incubated for three weeks at 25°C and 90% relative humidity. The results indicated that the five clogged tested filters had various fungal growth capacities depending on their water retention capacity. Preloaded filters were subjected to a simulated ventilation restart in a controlled filtration device to quantify that the fraction of particles released was around 1% for the G4, 0.1% for the M5 and the M6, and 0.001% for the F7 and the combined F7 filter. The results indicate that the likelihood of fungal particle release by low efficiency filters is significantly higher than by high efficiency filters. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Direct E-jet printing of three-dimensional fibrous scaffold for tendon tissue engineering.

    Science.gov (United States)

    Wu, Yang; Wang, Zuyong; Ying Hsi Fuh, Jerry; San Wong, Yoke; Wang, Wilson; San Thian, Eng

    2017-04-01

    Tissue engineering (TE) offers a promising strategy to restore diseased tendon tissue. However, a suitable scaffold for tendon TE has not been achieved with current fabrication techniques. Herein, we report the development of a novel electrohydrodynamic jet printing (E-jetting) for engineering 3D tendon scaffold with high porosity and orientated micrometer-size fibers. The E-jetted scaffold comprised tubular multilayered micrometer-size fibrous bundles, with interconnected spacing and geometric anisotropy along the longitudinal direction of the scaffold. Fiber diameter, stacking pattern, and interfiber distance have been observed to affect the structural stability of the scaffold, of which the enhanced mechanical strength can be obtained for scaffolds with thick fibers as the supporting layer. Human tenocytes showed a significant increase in cellular metabolism on the E-jetted scaffolds as compared to that on conventional electrospun scaffolds (2.7-, 2.8-, and 3.1-fold increase for 150, 300, and 600 µm interfiber distance, respectively; p scaffolds provided structural support for human tenocytes to align with controlled orientation along the longitudinal direction of the scaffold, and promoted the expression of collagen type I. For the first time, E-jetting has been explored as a novel scaffolding approach for tendon TE, and offers a 3D fibrous scaffold to promote organized tissue reconstruction for potential tendon healing. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 616-627, 2017.

  6. Core-shell fibrous stem cell carriers incorporating osteogenic nanoparticulate cues for bone tissue engineering.

    Science.gov (United States)

    Olmos Buitrago, Jennifer; Perez, Roman A; El-Fiqi, Ahmed; Singh, Rajendra K; Kim, Joong-Hyun; Kim, Hae-Won

    2015-12-01

    Moldable hydrogels that incorporate stem cells hold great promise for tissue engineering. They secure the encapsulated cells for required periods while allowing a permeable exchange of nutrients and gas with the surroundings. Core-shell fibrous structured hydrogel system represents these properties relevant to stem cell delivery and defect-adjustable tissue engineering. A designed dual concentric nozzle is used to simultaneously deposit collagen and alginate with a core-shell structured continuous fiber form in the ionic calcium bath. We aimed to impart extrinsic osteogenic cues in the nanoparticulate form, i.e., bioactive glass nanoparticles (BGn), inside the alginate shell, while encapsulating rat mesenchymal stem cells in the collagen core. Ionic measurement in aqueous solution indicated a continuous release of calcium ions from the BGn-added and -free scaffolds, whereas silicon was only released from the BGn-containing scaffolds. The presence of BGn allowed higher number of cells to migrate into the scaffolds when implanted in subcutaneous tissues of rat. Cell viability was preserved in the presence of the BGn, with no significant differences noticed from the control. The presence of BGn enhanced the osteogenic differentiation of the encapsulated rat mesenchymal stem cells, presenting higher levels of alkaline phosphatase activity as well as bone related genes, including collagen type I, bone sialoprotein and osteocalcin. Taken together, the incorporated BGn potentiated the capacity of the core-shell fibrous hydrogel system to deliver stem cells targeting bone tissue engineering. Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  7. A Cyanine Dye Encapsulated Porous Fibrous Mat for Naked-Eye Ammonia Sensing.

    Science.gov (United States)

    Ji, Chendong; Ma, Lijing; Yin, Meizhen; Yang, Wantai; Pan, Kai

    2016-08-19

    Electrospun ultrathin fiber-based sensors are desirable because of their practicality and sensitivity. Ammonia-detection systems are in high demand in different areas, including the industrial and agricultural fields. However, current technologies rely on large and complex instruments that restrict their actual utilization. Herein, we report a flexible naked-eye ammonia sensor, the polylactic acid-cyanine (PLA-Cy) fibrous mat, which was fabricated by blending a carboxyl-functionalized cyanine dye (D1) into electospun PLA porous fibers. The sensing mat was shown to undergo a naked-eye-detectable color change from white to blue upon exposure to ammonia vapor. The mat showed high selectivity to ammonia gas with a detection limit of 3.3 ppm. Aggregated D1 was first encapsulated by PLA and was then ionized by NH3 . These mechanisms were examined by photophysical studies and scanning electron microscopy. The aggregation-deaggregation process of D1 in the PLA-Cy fibrous mat led to the color change. This work provides a facile method for the naked-eye detection of ammonia and a novel strategy for the use of organic dyes in ammonia sensing.

  8. Fibrous and protoplasmic astrocytes express GABAA receptors that differ in benzodiazepine pharmacology.

    Science.gov (United States)

    Rosewater, K; Sontheimer, H

    1994-02-04

    Astrocytes cultured from spinal cord contain two morphologically distinguishable types of astrocytes: fibrous and protoplasmic cells. Both astrocyte subtypes, in culture, are able to express GABAA receptors, and their activation results in inward currents at the resting potential. Using patch-clamp electrophysiology we characterized their basic receptor pharmacology and compared it to spinal cord neurons that were also present in small numbers in these cultures. As in neuronal GABAA receptors, the local anesthetic pentobarbital effectively potentiated GABA-induced currents in both astrocyte subtypes. Similarly, the benzodiazepine diazepam, on average doubled GABA-induced currents in both astrocytes subtypes. In contrast to these effects that were similar in both astrocytes types and similar to spinal cord neurons, the response to the convulsant methyl-4-ethyl-6,7-dimethoxy-beta-carboline-3-carboxylate (DMCM), which is an inverse benzodiazepine agonist differs between astrocyte subtypes. DMCM reduced GABA-induced currents by about 50% in fibrous astrocytes as we also observed with spinal cord neurons. In contrast, DMCM increased GABA currents in protoplasmic astrocytes by up to 150%, an effect never observed in neurons. DMCM potentiations of GABA currents have recently been attributed to differences in receptor subunit composition. Our results thus indicate that subtypes of astrocytes express GABAA receptors that differ pharmacologically and likely differ also in subunit composition.

  9. Fabrication of highly aligned fibrous scaffolds for tissue regeneration by centrifugal spinning technology

    Energy Technology Data Exchange (ETDEWEB)

    Loordhuswamy, Amalorpava Mary [Department of Textile Technology, Anna University, Chennai 600025 (India); Krishnaswamy, Venkat Raghavan; Korrapati, Purna Sai [Department of Biomaterials, CSIR-Central Leather Research Institute, Chennai 600020 (India); Thinakaran, Senthilram [Department of Textile Technology, Anna University, Chennai 600025 (India); Rengaswami, Giri Dev Venkateshwarapuram, E-mail: vrgiridev@yahoo.com [Department of Textile Technology, Anna University, Chennai 600025 (India)

    2014-09-01

    Centrifugal spinning (C-Spin) is an emerging technology which uses centrifugal force to produce ultrafine fibers. Being a voltage free technique it can overcome the limitations of electrospinning. Owing to the unique characteristic features such as high surface area to volume ratio, porosity, mechanical strength and fiber alignment, centrifugal spun (C-spun) fibrous mat has a wide range of scope in various biomedical applications. Higher degree of fiber alignment can be effortlessly achieved by the C-Spin process. In order to prove the versatility of C-Spin system with respect to fiber alignment, Polycaprolactone (PCL) and gelatin were spun taking them as model polymers. The morphological analysis revealed that highly aligned ultrafine fibers with smooth surface are achieved by C-Spinning. Hydrophilicity, porosity and mechanical property results confirm that the C-spun mat is more suitable for tissue engineering applications. In vitro and in vivo experiments proved that the scaffolds are biocompatible and can be efficiently used as a wound dressing material. - Highlights: • Highly aligned PCL/gelatin fibrous scaffolds were prepared by C-Spinning system. • Degree of fiber alignment was influenced by the proportion of gelatin in the blends. • Direction of cell growth was parallel to the direction of fiber alignment. • C-Spun matrices can efficiently accelerate faster wound healing.

  10. Effect of crystals and fibrous network polymer additives on cellular morphology of microcellular foams

    Science.gov (United States)

    Miyamoto, Ryoma; Utano, Tatsumi; Yasuhara, Shunya; Ishihara, Shota; Ohshima, Masahiro

    2015-05-01

    In this study, the core-back foam injection molding was used for preparing microcelluar polypropylene (PP) foam with either a 1,3:2,4 bis-O-(4-methylbenzylidene)-D-sorbitol gelling agent (Gel-all MD) or a fibros network polymer additive (Metablen 3000). Both agent and addiive could effectively control the celluar morphology in foams but somehow different ways. In course of cooling the polymer with Gel-all MD in the mold caity, the agent enhanced the crystal nucleation and resulted in the large number of small crystals. The crystals acted as effective bubble nucleation agent in foaming process. Thus, the agent reduced the cell size and increased the cell density, drastically. Furthermore, the small crystals provided an inhomogenuity to the expanding cell wall and produced the high open cell content with nano-scale fibril structure. Gell-all as well as Metablene 3000 formed a gel-like fibrous network in melt. The network increased the elongational viscosity and tended to prevent the cell wall from breaking up. The foaming temperature window was widened by the presence of the network. Especially, the temperature window where the macro-fibrous structure was formed was expanded to the higher temperature. The effects of crystal nucleating agent and PTFE on crystals' size and number, viscoelsticity, rheological propreties of PP and cellular morphology were compared and thorougly investigated.

  11. In situ degradability of dry matter and fibrous fraction of sorghum silage

    Directory of Open Access Journals (Sweden)

    Renê Ferreira Costa

    2016-05-01

    Full Text Available This study aimed to evaluate in situ degradability and degradation kinetics of DM, NDF and ADF of silage, with or without tannin in the grains. Two isogenic lines of grain sorghum (CMS-XS 114 with tannin and CMS-XS 165 without tannin and two sorghum hybrids (BR-700 dual purpose with tannin and BR-601 forage without tannin were ensiled; dried and ground silage samples were placed in nylon bags and introduced through the fistulas. After incubation for 6, 12, 24, 48, 72 and 96 hours, bags were taken for subsequent analysis of fibrous fractions. The experimental design was completely randomized with 4 replicates and 4 treatments and means compared by Tukey’s test at 5% probability. As for the DM degradation rate, silage of CMSXS165without tannin was superior. Silages of genotypes BR700 and CMSXS 114 with tannin showed the highest values of indigestible ADF (59.54 and 43.09%. Regarding the NDF, the potential degradation of silage of CMSXS165 line without tannin was superior. Tannin can reduce ruminal degradability of the dry matter and fibrous fractions.

  12. Living nano-micro fibrous woven fabric/hydrogel composite scaffolds for heart valve engineering.

    Science.gov (United States)

    Wu, Shaohua; Duan, Bin; Qin, Xiaohong; Butcher, Jonathan T

    2017-01-18

    Regeneration and repair of injured or diseased heart valves remains a clinical challenge. Tissue engineering provides a promising treatment approach to facilitate living heart valve repair and regeneration. Three-dimensional (3D) biomimetic scaffolds that possess heterogeneous and anisotropic features that approximate those of native heart valve tissue are beneficial to the successful in vitro development of tissue engineered heart valves (TEHV). Here we report the development and characterization of a novel composite scaffold consisting of nano- and micro-scale fibrous woven fabrics and 3D hydrogels by using textile techniques combined with bioactive hydrogel formation. Embedded nano-micro fibrous scaffolds within hydrogel enhanced mechanical strength and physical structural anisotropy of the composite scaffold (similar to native aortic valve leaflets) and also reduced its compaction. We determined that the composite scaffolds supported the growth of human aortic valve interstitial cells (HAVIC), balanced the remodeling of heart valve ECM against shrinkage, and maintained better physiological fibroblastic phenotype in both normal and diseased HAVIC over single materials. These fabricated composite scaffolds enable the engineering of a living heart valve graft with improved anisotropic structure and tissue biomechanics important for maintaining valve cell phenotypes.

  13. A case of primary malignant fibrous histiocytoma of the pancreas: CT and MRI findings

    Institute of Scientific and Technical Information of China (English)

    Ri-Sheng Yu; Jia-Wei Wang; Ying Chen; Wen-Hong Ding; Xiu-Fang Xu; Li-Rong Chen

    2008-01-01

    Primary malignant fibrous histiocytoma (MFH) of the pancreas is rare and a distinct clinical entity. We report a case of recurrence of pancreatic MFH with computed tomography (CT) and magnetic resonance imaging (MRI)findings. A 67-year-old man presented with a history of decreased body weight over the past 6 mo. Abdominal CT revealed a large, multilocular cystic mass in the head of the pancreas with obvious atrophy in the body and tail of the pancreas. After 6 mo postoperatively, MRI demonstrated a recurrent large mass in the primary area of the head of the pancreas. The lesion was heterogeneous, hypointense to the liver on Tl-weighted imaging, and heterogeneously hyperintense to the liver with a hypointense area in the central part of the tumor on fat-saturated T2-weighted imaging. Contrastenhanced Tl-weighted imaging demonstrated a large multilocular cystic mass with a cystic wall, fibrous septa and enhancement of solid components. To the best of our knowledge, this is the first report on recurrence of primary MFH of the pancreas, and the first with MRI findings.

  14. Room-temperature electrolytic coloration and spectral properties of natural fibrous gypsum using a pointed anode

    Energy Technology Data Exchange (ETDEWEB)

    Gu, Hongen, E-mail: jthgu@163.com; Hao, Xiaoqing; Tian, Pin

    2014-01-15

    Electrolysis experiments can be performed at room temperature and under various voltages using natural fibrous (NF) gypsum with a pointed anode and a flat cathode. The NF gypsum is colored electrolytically. SO{sub 4}{sup −}, SO{sub 3}{sup −}, SO{sub 2}{sup −}, O{sub 3}{sup −} and O{sup −} defect centers are produced in colored NF gypsum. The characteristic absorption bands of the defect centers are observed in the absorption spectra of the colored NF gypsum. The defect centers come mainly from electric-field-induced decomposition and/or direct electron loss of SO{sub 4}{sup 2−} radicals. Current is measured during electrolytic coloration. Electron exchanges from electron and charged radicals to electrodes induce complete current. -- Highlights: • We expanded the traditional electrolysis method. • Electrolysis experiments are performed at room temperature for the first time. • Natural fibrous gypsum is colored electrolytically. • SO{sub 4}{sup −}, SO{sub 3}{sup −}, SO{sub 2}{sup −}, O{sub 3}{sup −} and O{sup −} defect centers are produced in colored gypsum. • Defect centers come from electron transfers and decomposition of SO{sub 4}{sup 2−} radicals.

  15. An environmentally friendly process; Adsorption of radionuclide Tl-201 on fibrous waste tea

    Energy Technology Data Exchange (ETDEWEB)

    Eroglu, Hayrettin [Atatuerk Universitesi, Arastirma Hastanesi, Nuekleer Tip Ana Bilim Dali, 25240 Erzurum (Turkey); Yapici, Sinan [Atatuerk Universitesi, Muehendislik Fakueltesi, Kimya Muehendisligi Boeluemue, 25240 Erzurum (Turkey)], E-mail: syapici@atauni.edu.tr; Nuhoglu, Cigdem [Atatuerk Universitesi, Fen-Edebiyat Fakueltesi, Fizik Boeluemue, 25240 Erzurum (Turkey); Varoglu, Erhan [Atatuerk Universitesi, Arastirma Hastanesi, Nuekleer Tip Ana Bilim Dali, 25240 Erzurum (Turkey)

    2009-04-30

    This work presents an investigation of the adsorption of the radionuclide of Tl-201 from waste water on the fibrous tea factory waste. The experimental parameters were chosen as temperature, pH, stirring speed, adsorbent dose and nominal particle size in the ranges of 10.0-40.0 deg. C, 2.0-10.0, 300-720 rpm, 1.0-15.0 g/L and 0.15-0.71 mm, respectively. The most effective parameter on the adsorption yield was found to be pH of the solution. Fourier transforms infrared and electron paramagnetic resonance spectroscopy studies were performed for the characterisation of the adsorption on tea waste. The experimental data were found to be in good agreement with the isotherm models of Freundlich, Halsey, Handerson and Dubinin-Radushkevich. Thermodynamic analysis showed that the values of {delta}G and {delta}H are negative. It was obtained that the adsorption rate can be represented very well by second-order pseudo homogeneous kinetic model. All the results proved that fibrous tea plant waste makes an excellent adsorbent for Tl-201 radionuclide.

  16. Optimization of sound absorbing performance for gradient multi-layer-assembled sintered fibrous absorbers

    Science.gov (United States)

    Zhang, Bo; Zhang, Weiyong; Zhu, Jian

    2012-04-01

    The transfer matrix method, based on plane wave theory, of multi-layer equivalent fluid is employed to evaluate the sound absorbing properties of two-layer-assembled and three-layer-assembled sintered fibrous sheets (generally regarded as a kind of compound absorber or structures). Two objective functions which are more suitable for the optimization of sound absorption properties of multi-layer absorbers within the wider frequency ranges are developed and the optimized results of using two objective functions are also compared with each other. It is found that using the two objective functions, especially the second one, may be more helpful to exert the sound absorbing properties of absorbers at lower frequencies to the best of their abilities. Then the calculation and optimization of sound absorption properties of multi-layer-assembled structures are performed by developing a simulated annealing genetic arithmetic program and using above-mentioned objective functions. Finally, based on the optimization in this work the thoughts of the gradient design over the acoustic parameters- the porosity, the tortuosity, the viscous and thermal characteristic lengths and the thickness of each samples- of porous metals are put forth and thereby some useful design criteria upon the acoustic parameters of each layer of porous fibrous metals are given while applying the multi-layer-assembled compound absorbers in noise control engineering.

  17. Liquid perfluorochemical-supported hybrid cell culture system for proliferation of chondrocytes on fibrous polylactide scaffolds.

    Science.gov (United States)

    Pilarek, Maciej; Grabowska, Iwona; Senderek, Ilona; Wojasiński, Michał; Janicka, Justyna; Janczyk-Ilach, Katarzyna; Ciach, Tomasz

    2014-09-01

    CP5 bovine chondrocytes were cultured on biodegradable electrospun fibrous polylactide (PLA) scaffolds placed on a flexible interface formed between two immiscible liquid phases: (1) hydrophobic perfluorochemical (PFC) and (2) aqueous culture medium, as a new way of cartilage implant development. Robust and intensive growth of CP5 cells was achieved in our hybrid liquid-solid-liquid culture system consisting of the fibrous PLA scaffolds in contrast to limited growth of the CP5 cells in traditional culture system with PLA scaffold placed on solid surface. The multicellular aggregates of CP5 cells covered the surface of PLA scaffolds and the chondrocytes migrated through and overgrew internal fibers of the scaffolds. Our hybrid culture system simultaneously allows the adhesion of adherent CP5 cells to fibers of PLA scaffolds as well as, due to use of phase of PFC, enhances the mass transfer in the case of supplying/removing of respiratory gases, i.e., O2 and CO2. Our flexible (independent of vessel shape) system is simple, ready-to-use and may utilize a variety of polymer-based scaffolds traditionally proposed for implant development.

  18. Bilateral fibrous replacement of subclavius muscle in relation to nerve and artery compression of the upper limb

    Directory of Open Access Journals (Sweden)

    Georgiev GP

    2009-06-01

    Full Text Available Here, we report an interesting case of bilateral fibrous structures found in the costoclavicular space of a 58-year-old male cadaver during routine anatomical dissection. On the left side, a strong fibrous band extending between the inferior surface of the lateral two-thirds of the clavicle and the coracoid process to the medial end of the first rib was found. On the right side, a similar but thinner structure was discovered. On both sides the variant fibrous structures replacing the subclavius muscle, reduced the costoclavicular space thus led to a possible entrapment site for the brachial plexus and the subclavian/axillary vessels, and may be involved in the development of thoracic outlet syndrome.

  19. Integrated therapeutic approach to giant solitary fibrous tumor of the pleura: report of a case and review of the literature

    Directory of Open Access Journals (Sweden)

    Perrotta Fabio

    2016-01-01

    Full Text Available The fibrous tumors of the pleura are rare primary tumors, accounting for 5% of malignant pleural neoplasms, which generally originate from sub-mesothelial mesenchymal tissue of the visceral pleura. These tumours generally exhibit clinical benign behavior although 12% of solitary fibrous tumors can be malignant and have worse outcomes. These tumors are considered “giant” when the lesion > 15 cm. Surgical treatment is the best choice for both benign and malignant neoplasms. We retrospectively analyzed the main case series of giant fibrous tumors of the pleura. In addition we report our experience of a 76-year-old woman treated by pre-surgical embolization involving implantation of vascular plugs. Surgery was successfully carried out without complications; imaging and functional assessment 6 months post intervention demonstrated both the absence of recurrence and improvement of lung function parameters.

  20. Monitoring environmental risk in fibrous minerals in New Caledonia: a comparison between different analytical methods.

    Science.gov (United States)

    Petriglieri, Jasmine Rita; Laporte-Magoni, Christine; Salvioli-Mariani, Emma; Gunkel-Grillon, Peggy; Tribaudino, Mario; Mantovani, Luciana; Bersani, Danilo; Lottici, Pier Paolo; Tomatis, Maura

    2017-04-01

    The New Caledonia is covered by ultrabasic units for more than a third of its surface, and it is one of the largest world producers of nickel ore. Mining activity, focused on extraction from lateritic ore deposits formed by the alteration of ultramafic rocks, must deal with the natural occurrence of asbestos and fibrous minerals. Almost all outcrops of geological units in open mines contain serpentine and amphibole, also as asbestos varieties (Lahondère, 2007). Owing to humid tropical to sub-tropical conditions, weathering processes and supergene mineralization are one of the main responsible for fibrogenesis of asbestos minerals. The presence of fibrous minerals in mining and storage sites requires attention due to public health problems and for the safety of the operators. In this context, the evaluation of risk and health hazard to prevent the effects due to exposition is closely linked to the formation, alteration and release of fibers into the environment. It has been demonstrated that different fibrous minerals have different toxicity (Fubini & Otero-Arean, 1999; Fubini & Fenoglio, 2007). An analytical strategy to discriminate and characterize, with certainty, the different varieties of the asbestiform phases is required to the establishment of an environmental monitoring system. We have therefore analyzed by different methods a set of about fifty asbestos sampled for mapping environmental risk in fibrous minerals in New Caledonia. The samples contain serpentines (chrysotile, antigorite) and amphibole (tremolite), all fibrous and have been sorted by their different degree of alteration. Data obtained with the more traditional mineralogical and petrological analytical techniques - such as optical microscopy, X-ray diffraction, secondary electron microscopy (SEM-EDS), and transmission electron microscopy - have been completed by the employment of more specialized tools as phase contrast microscopy (PCM), Raman spectroscopy, and thermal analysis (DTA). Moreover

  1. Tailorable Release of Small Molecules Utilizing Plant Viral Nanoparticles and Fibrous Matrix

    Science.gov (United States)

    Cao, Jing

    We have engineered Red clover necrotic mosaic virus (RCNMV) derived plant viral nanoparticles (PVNs) within a fibrous matrix to optimize its application for delivery and controlled release of active ingredients. RCNMV's structure and unique response to divalent cation depletion and re-addition enables the infusion of small molecules into its viral capsid through a pore formation mechanism. While this PVN technology shows a potential use in nano-scale therapeutic drug delivery, its inherent molecular dynamics to environmental stimuli places a constraint on its application and functionality as a vehicle for tailorable release of loading cargo. In this study, we enhance the understanding of the PVN technology by elucidating its mechanism for loading and triggered release of doxorubicin (Dox), a chemotherapeutic drug for breast cancer. Of critical importance is the methodology for manipulation of Dox's loading capacity and its binding location on either the exterior or interior of the virion capsid. The ability to control the active ingredient binding location provides an additional approach of tunable release from the PVN delivery vehicle besides its inherent pH- and ion- responsive release of loading cargo. The efficacious and controlled release strategy for agricultural active ingredients, such as nematicides, is also a large social need right now. Crop infestation of plant parasite nematodes causes in excess of 157 billion in worldwide crop damage annually. If an effective control strategy for these pests could be developed, it is estimated that the current market for effective nematicides is between 700 million and $1 billion each year worldwide. In this study, we report on the utilization of PVN technology to encapsulate the biological nematicide, abamectin (Abm), within the PVN's interior capsid (PVNAbm). Creating PVNAbm addresses Abm's issues of soil immobility while rendering a controlled release strategy for its bioavailability to root knot nematodes (RKNs

  2. Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Yao Dianbo

    2012-01-01

    Full Text Available Abstract Background A malignant fibrous histiocytoma is a soft tissue tumor that most commonly occurs in the extremities, but rarely involves the liver. The clinical characteristics and therapeutic experiences of primary hepatic malignant fibrous histiocytoma are still limited. Methods Two cases of primary hepatic malignant fibrous histiocytoma were analyzed retrospectively, and all the literature concerning primary hepatic malignant fibrous histiocytoma was analyzed. Results In China, a total of 76 cases had been reported, among which 50 were men, with a male to female ratio of 1.9:1. Mean age of the patients was 51.0 years old, and more than 85 percent were older than 40 years. 82.9 percent (63/76 of hepatic MFH were solitary lesions, with tumor size ranging from 2.5 to 23.5 cm (average 10.3 cm. Major clinical presentation (78.4% was abdominal pain or discomfort, accompanied with some other non-specific symptoms such as malaise, anorexia, weight loss, jaundice and fever, and small cases (14.9% were asymptomatic. Computed tomography and ultrasound usually revealed the location of lesions. The rate of pre-operative misdiagnosis was extremely high, and 14.9 percent of patients were even misdiagnosed as a benign liver cyst, liver abscess or hematoma. Integrated resection was performed among the most cases (49/68, among which only a few ones (12 cases were introduced to have no recurrence or metastasis or be still alive with no detail information provided, while among the cases with palliative operation or only a biopsy, the cases that were followed-up all died. Conclusions Hepatic malignant fibrous histiocytoma is a rare malignant mesenchymal tumor. The variable features of clinical presentations and images make the diagnosis difficult. Though the prognosis of primary hepatic malignant fibrous histiocytoma was rather poor, integrated resection might provide a few cases a good opportunity for surviving, suggesting that surgery might be an effective

  3. Polydopamine Inter-Fiber Networks: New Strategy for Producing Rigid, Sticky, 3D Fluffy Electrospun Fibrous Polycaprolactone Sponges.

    Science.gov (United States)

    Choi, Wuyong; Lee, Slgirim; Kim, Seung-Hyun; Jang, Jae-Hyung

    2016-06-01

    Designing versatile 3D interfaces that can precisely represent a biological environment is a prerequisite for the creation of artificial tissue structures. To this end, electrospun fibrous sponges, precisely mimicking an extracellular matrix and providing highly porous interfaces, have capabilities that can function as versatile physical cues to regenerate various tissues. However, their intrinsic features, such as sheet-like, thin, and weak structures, limit the design of a number of uses in tissue engineering applications. Herein, a highly facile methodology capable of fabricating rigid, sticky, spatially expanded fluffy electrospun fibrous sponges is proposed. A bio-inspired adhesive material, poly(dopamine) (pDA), is employed as a key mediator to provide rigidity and stickiness to the 3D poly(ε-caprolactone) (PCL) fibrous sponges, which are fabricated using a coaxial electrospinning with polystyrene followed by a selective leaching process. The iron ion induced oxidation of dopamine into pDA networks interwoven with PCL fibers results in significant increases in the rigidity of 3D fibrous sponges. Furthermore, the exposure of catecholamine groups on the fiber surfaces promotes the stable attachment of the sponges on wet organ surfaces and triggers the robust immobilization of biomolecules (e.g., proteins and gene vectors), demonstrating their potential for 3D scaffolds as well as drug delivery vehicles. Because fibrous structures are ubiquitous in the human body, these rigid, sticky, 3D fibrous sponges are good candidates for powerful biomaterial systems that functionally mimic a variety of tissue structures. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Where is iron in erionite? A multidisciplinary study on fibrous erionite-Na from Jersey (Nevada, USA)

    OpenAIRE

    Gualtieri, Alessandro F.; Nicola Bursi Gandolfi; Simone Pollastri; Kilian Pollok; Falko Langenhorst

    2016-01-01

    Fibrous erionite is a mineral fibre of great concern but to date mechanisms by which it induces cyto- and geno-toxic damage, and especially the role of iron associated to this zeolite species, remain poorly understood. One of the reasons is that we still don’t know exactly where iron is in natural erionite. This work is focused on fibrous erionite-Na from Jersey (Nevada, USA) and attempts to draw a general model of occurrence of iron in erionite and relationship with toxicity mechanisms. It w...

  5. Rock physics of fibrous rocks akin to Roman concrete explains uplifts at Campi Flegrei Caldera

    Science.gov (United States)

    Vanorio, Tiziana; Kanitpanyacharoen, Waruntorn

    2015-08-01

    Uplifts in the Campi Flegrei caldera reach values unsurpassed anywhere in the world (~2 meters). Despite the marked deformation, the release of strain appears delayed. The rock physics analysis of well cores highlights the presence of two horizons, above and below the seismogenic area, underlying a coupled process. The basement is a calc-silicate rock housing hydrothermal decarbonation reactions, which provide lime-rich fluids. The caprock above the seismogenic area has a pozzolanic composition and a fibril-rich matrix that results from lime-pozzolanic reactions. These findings provide evidence for a natural process reflecting that characterizing the cementitious pastes in modern and Roman concrete. The formation of fibrous minerals by intertwining filaments confers shear and tensile strength to the caprock, contributing to its ductility and increased resistance to fracture.

  6. Calcifying fibrous pseudotumor in association with hyaline vascular type Castleman′s disease

    Directory of Open Access Journals (Sweden)

    Azam Muhammad

    2009-10-01

    Full Text Available Calcifying fibrous pseudotumor is a recently described rare entity. It is considered as sclerosing end stage of inflammatory myofibroblastic tumor. An association with hyaline vascular type Castleman′s disease has also been described. We report a case of a 13-year-old boy who presented with pain in epigastrium. Computed tomography scan of abdomen revealed a circumscribed mass arising from the gastric wall along the greater curvature. Histology revealed a tumor composed of spindle cells present within the dense hyalinized collagenous tissue. Lymphoplasmacytic infiltrate was seen along with lymphoid follicles, dystrophic and ossifying calcification. Tumor cells were focally positive for alpha smooth muscle actin and negative for anaplastic lymphoma kinase protein.

  7. Heat Transfer Modeling and Validation for Optically Thick Alumina Fibrous Insulation

    Science.gov (United States)

    Daryabeigi, Kamran

    2009-01-01

    Combined radiation/conduction heat transfer through unbonded alumina fibrous insulation was modeled using the diffusion approximation for modeling the radiation component of heat transfer in the optically thick insulation. The validity of the heat transfer model was investigated by comparison to previously reported experimental effective thermal conductivity data over the insulation density range of 24 to 96 kg/cu m, with a pressure range of 0.001 to 750 torr (0.1 to 101.3 x 10(exp 3) Pa), and test sample hot side temperature range of 530 to 1360 K. The model was further validated by comparison to thermal conductivity measurements using the transient step heating technique on an insulation sample at a density of 144 kg/cu m over a pressure range of 0.001 to 760 torr, and temperature range of 290 to 1090 K.

  8. Preparation and characterization of fibrous NiO particles by thermal decomposition of nickelous complex precursors

    Institute of Scientific and Technical Information of China (English)

    张传福; 湛菁; 邬建辉; 黎昌俊

    2004-01-01

    The influences of pyrolytic conditions, including temperature, time, the flow rate of air, and the heating rate, on the morphology, average size and specific surface area of the NiO particles were investigated, and the composition and morphologies of the products were characterized by using of XRD, SEM and BET. It is found that fibrous NiO particles were produced under the optimal conditions. A suitable range of pH for preparing dispersive precursors was chosen according to analysis of zeta potential. Based on the observations of NiO precursors growth and SEM morphology of the precursor, the oriented attachment was proposed for the well-aligned growth of the NiO precursor fibres. The final product NiO inherits the morphology of the precursor.

  9. Fabrication and characterization of electrospun poly(e-caprolactone) fibrous membrane with antibacterial functionality

    Science.gov (United States)

    Cerkez, Idris; Sezer, Ayse; Bhullar, Sukhwinder K.

    2017-02-01

    This research study is mainly targeted on fabrication and characterization of antibacterial poly(e-caprolactone) (PCL) based fibrous membrane containing silver chloride particles. Micro/nano fibres were produced by electrospinning and characterized with TGA, DSC, SEM and mechanical analysis. It was found that addition of silver particles slightly reduced onset of thermal degradation and increased crystallization temperature of neat PCL. Silver-loaded samples exhibited higher tensile stress and lower strain revealing that the particles behaved as reinforcing agent. Moreover, addition of silver chloride resulted in beaded surface texture and formation of finer fibres as opposed to the neat. Antibacterial properties were tested against Gram-negative and Gram-positive bacteria and remarkable biocidal functionalities were obtained with about six logs reduction of Staphylococcus aureus and Escherichia coli O157:H7.

  10. Preparation and Characterization of Polyvinylidene Fluoride/Graphene Superhydrophobic Fibrous Films

    Directory of Open Access Journals (Sweden)

    Rasoul Moradi

    2015-08-01

    Full Text Available A new strategy to induce superhydrophobicity via introducing hierarchical structure into the polyvinylidene fluoride (PVDF film was explored in this study. For this purpose nanofibrous composite films were prepared by electrospinning of PVDF and PVDF/graphene blend solution as the main precursors to produce a net-like structure. Various spectroscopy and microscopy methods in combination with crystallographic and wettability tests were used to evaluate the characteristics of the synthesized films. Mechanical properties have been studied using a universal stress-strain test. The results show that the properties of the PVDF nanofibrous film are improved by compositing with graphene. The incorporation of graphene flakes into the fibrous polymer matrix changes the morphology, enhances the surface roughness, and improves the hydrophobicity by inducing a morphological hierarchy. Superhydrophobicity with the water contact angle of about 160° can be achieved for the PVDF/graphene electrospun nanocomposite film in comparison to PVDF pristine film.

  11. Focal fibrocartilaginous dysplasia ("fibrous periosteal inclusion"): an additional series of eleven cases and literature review.

    Science.gov (United States)

    Jouve, Jean-Luc; Kohler, Remi; Mubarak, Scott J; Nelson, Scott C; Dohin, Bruno; Bollini, Gerard

    2007-01-01

    Focal fibrocartilaginous dysplasia (FFCD) is a benign condition first described in 1985 as a cause of tibia vara. We are reporting on 11 cases. The lesions involved proximal tibia (9 cases), distal femur (1 case), and distal ulna (1 case). We believe that this entity represents a bony anchor preventing natural sliding of the periosteum during growth (an "epiphysiodesis-like" effect). For the tibia, we believe this is the pes anserinus. We are suggesting that this entity be called a "fibrous periostal inclusion." Treatment indications result from this concept: (1) for tibial lesions with a metaphyseal-diaphyseal angle less than 20 degrees observation for 6 to 12 months; (2) if the deformity improves, the tether likely broke spontaneously, and no treatment is required; and (3) curettage early if the deformity worsens. This will be followed by rapid correction into physiological valgus (tibia) and prevent the need for osteotomy. Early curettage for other less common locations is recommended.

  12. Long Range Force Transmission in Fibrous Matrices Enabled by Tension-Driven Alignment of Fibers

    CERN Document Server

    Wang, Hailong; Chen, Christopher S; Wells, Rebecca G; Shenoy, Vivek B

    2014-01-01

    Cells can sense and respond to mechanical signals over relatively long distances across fibrous extracellular matrices. Here, we explore all of the key factors that influence long range force transmission in cell-populated collagen matrices: alignment of collagen fibers, responses to applied force, strain stiffening properties of the aligned fibers, aspect ratios of the cells, and the polarization of cellular contraction. A constitutive law accounting for mechanically-driven collagen fiber reorientation is proposed. We systematically investigate the range of collagen fiber alignment using both finite element simulations and analytical calculations. Our results show that tension-driven collagen fiber alignment plays a crucial role in force transmission. Small critical stretch for fiber alignment, large fiber stiffness and fiber strain hardening behavior enable long-range interaction. Furthermore, the range of collagen fiber alignment for elliptical cells with polarized contraction is much larger than that for ...

  13. Two Cases of Solitary Fibrous Tumor Involving Urinary Bladder and a Review of the Literature

    Science.gov (United States)

    Buonfiglio, Vitor Bonadia; Manzano, Joao Padua; Filippi, Renée Zon; Sadi, Marcus Vinicius

    2016-01-01

    Solitary fibrous tumor (SFT) is a rare neoplasia of mesenchymal origin, initially described in visceral pleura and lately discovered to have ubiquitous distribution. SFT of the urogenital tract is uncommon and appears to have similar morphologic features and biologic behaviors as SFTs found elsewhere. We present two new cases of SFT of the bladder and review 22 similar cases published in the literature. Due to the general indolent behavior of these lesions, a complete but organ sparing surgical excision should be considered when technically feasible. Therefore, proper identification and characterization of SFT through morphological and immunohistochemical criteria on biopsy specimens are mandatory in the differential diagnosis from other more aggressive spindle-cell tumors, thus avoiding unnecessary radical surgery.

  14. Design feasibility study of a divertor component reinforced with fibrous metal matrix composite laminate

    Energy Technology Data Exchange (ETDEWEB)

    You, J.-H. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Boltzmannstr. 2, D-85748 Garching (Germany)]. E-mail: j.h.you@ipp.mpg.de

    2005-01-01

    Fibrous metal matrix composites possess advanced mechanical properties compared to conventional alloys. It is expected that the application of these composites to a divertor component will enhance the structural reliability. A possible design concept would be a system consisting of tungsten armour, copper composite interlayer and copper heat sink where the composite interlayer is locally inserted into the highly stressed domain near the bond interface. For assessment of the design feasibility of the composite divertor concept, a non-linear multi-scale finite element analysis was performed. To this end, a micro-mechanics algorithm was implemented into a finite element code. A reactor-relevant heat flux load was assumed. Focus was placed on the evolution of stress state, plastic deformation and ductile damage on both macro- and microscopic scales. The structural response of the component and the micro-scale stress evolution of the composite laminate were investigated.

  15. Properties of composition sinter prepared from fibrous barium titanate and nanometer zirconia

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Fibrous Batium Titanate particles,30-50 μm long,prepared by a hydrothermal reaction,and the monoclinic phase and nanometer Zirconia,11.6 nm long were prepared by citric acid reaction respectively.Then,the two were composite sintered to produce a new functional material by making full use of crystal-axis orientation of fibers and the activity of nanometer powder.The analydid of composition and microstructure of the new material in terms of XRD and SEM.shows that the solid solution was formed between fibers and nanometer powder,and the distance between lattice(d value)of Barium Titanate changed.But the crystal-axis orientations of fibers remain unchanged.

  16. Charge transport in the electrospun nanofiber composite membrane's three-dimensional fibrous structure

    Science.gov (United States)

    DeGostin, Matthew B.; Peracchio, Aldo A.; Myles, Timothy D.; Cassenti, Brice N.; Chiu, Wilson K. S.

    2016-03-01

    In this paper, a Fiber Network (FN) ion transport model is developed to simulate the three-dimensional fibrous microstructural morphology that results from the electrospinning membrane fabrication process. This model is able to approximate fiber layering within a membrane as well as membrane swelling due to water uptake. The discrete random fiber networks representing membranes are converted to resistor networks and solved for current flow and ionic conductivity. Model predictions are validated by comparison with experimental conductivity data from electrospun anion exchange membranes (AEM) and proton exchange membranes (PEM) for fuel cells as well as existing theories. The model is capable of predicting in-plane and thru-plane conductivity and takes into account detailed membrane characteristics, such as volume fraction, fiber diameter, fiber conductivity, and membrane layering, and as such may be used as a tool for advanced electrode design.

  17. [Chronic subdural hematoma with a markedly fibrous hypertrophic membrane. Case report].

    Science.gov (United States)

    Sato, M; Kuwana, N; Kojima, Y; Tanaka, N; Kitamura, H

    1990-01-01

    A 40-year-old female, who had taken low-dose oral contraceptives for 2 months before onset, developed transient dysarthria, left hemiparesis, and left hemihypesthesia. One month later, a computed tomography (CT) scan revealed a uniformly enhanced, convex-shaped, hypertrophic membrane with a lobulated lumen in the subdural space of the right parietal region. A right parietal craniotomy was performed. The membrane, consisting of elastic-hard, hypertrophic granulation tissue and yellowish, sticky fluid in the lumen, was readily freed and totally extirpated. Subsequently, the patient recovered without persistent symptoms. Light microscopic examination detected the sinusoidal channel layer and the fibrous layer in an alternating configuration, along with intramembranous hemorrhagic foci. Such hypertrophy must have been caused by repeated intramembranous hemorrhages and reactive granulation. Such findings of hematoma membrane have never previously been reported. Thus, this is an interesting case, clearly distinguished from typical chronic subdural hematoma.

  18. Core-shell fibrous vascular grafts with the nitric oxide releasing property

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Small-diameter vascular grafts with the nitric oxide(NO) releasing property were designed and prepared.Diazeniumdiolated N,N’-dibutyl-1,6-hexanediamine(DBHD/N2O2) was first synthesized as the NO donor and doped into the biocompatible polymer poly(ε-caprolactone)(PCL).The fibrous vascular grafts were fabricated by electrospinning.Despite the reduced platelet adhesion observed on the NO releasing grafts,the cytotoxicity and burst release were apparent,especially at a higher loading level of the NO donor.In order to solve this problem,core-shell structured nanofibers,in which PCL or gelatin is the shell and PCL doped with the NO donor is the core,were fabricated via coaxial electrospinning.The core-shell structure made the NO release more steady and controllable,and the cell compatibility was improved.

  19. STUDY ON FIBROUS COMPOSITES BEHAVIOUR IN HYDRODYNAMIC PROCESS OF WINE FILTRATION

    Directory of Open Access Journals (Sweden)

    Petronela Nechita

    2009-11-01

    Full Text Available This study concerns the implementation and performance evaluation of fibrous composites in sterile filtration of wine. Conditions of preparation were established having in view that the separation of particulate contaminants from liquids by depth filtration is occurring by mechanical entrapment into structural pores and by electrokinetic adsorption, and both retention mechanisms are influenced by various factors. Functional characteristics and behaviour of the filtering composite in industrial filtration of wine were evaluated. It was found that the effectiveness with which micro-organisms were retained was substantially improved by a porous structure characterized by small pores, and respectively by high resistance to air filtration, as well as by a higher content of cationic charges in the system.

  20. Multi-scale modeling of soft fibrous tissues based on proteoglycan mechanics.

    Science.gov (United States)

    Linka, Kevin; Khiêm, Vu Ngoc; Itskov, Mikhail

    2016-08-16

    Collagen in the form of fibers or fibrils is an essential source of strength and structural integrity in most organs of the human body. Recently, with the help of complex experimental setups, a paradigm change concerning the mechanical contribution of proteoglycans (PGs) took place. Accordingly, PG connections protect the surrounding collagen fibrils from over-stretching rather than transmitting load between them. In this paper, we describe the reported PG mechanics and incorporate it into a multi-scale model of soft fibrous tissues. To this end, a nano-to-micro model of a single collagen fiber is developed by taking the entropic-energetic transition on the collagen molecule level into account. The microscopic damage occurring inside the collagen fiber is elucidated by sliding of PGs as well as by over-stretched collagen molecules. Predictions of this two-constituent-damage model are compared to experimental data available in the literature.

  1. Scanning electron microscopic observations of fibrous structure of cemento-dentinal junction in healthy teeth.

    Science.gov (United States)

    Pratebha, B; Jaikumar, N D; Sudhakar, R

    2014-01-01

    The cemento-dentinal junction (CDJ) is a structural and biologic link between cementum and dentin present in the roots of teeth. Conflicting reports about the origin, structure and composition of this layer are present in literature. The width of this junctional tissue is reported to be about 2-4 μm with adhesion of cementum and dentin by proteoglycans and by collagen fiber intermingling. The objective of this study is to observe and report the fibrous architecture of the CDJ of healthy tooth roots. A total of 15 healthy teeth samples were collected, sectioned into halves, demineralized in 5% ethylenediaminetetraacetic acid, processed using NaOH maceration technique and observed under a scanning electron microscope. The CDJ appeared to be a fibril poor groove with a width of 2-4 µm. Few areas of collagen fiber intermingling could be appreciated. A detailed observation of these tissues has been presented.

  2. Fibrous Agricultural Biomass as a Potential Source for Bioconversion to Vanillic Acid

    Directory of Open Access Journals (Sweden)

    Pei-Ling Tang

    2014-01-01

    Full Text Available This study was conducted to assess the potential of six fibrous agricultural residues, namely, oil palm empty fruit bunch fiber (OPEFBF, coconut coir fiber (CCF, pineapple peel (PP, pineapple crown leaves (PCL, kenaf bast fiber (KBF, and kenaf core fiber (KCF, as a source of ferulic acid and phenolic compounds for bioconversion into vanillic acid. The raw samples were pretreated with organosolv (NaOH-glycerol and alkaline treatment (NaOH, to produce phenol-rich black liquor. The finding showed that the highest amount of phenolic compounds and ferulic acid was produced from CCF and PP, respectively. This study also found that organosolv treatment was the superior method for phenolic compound extraction, whereas alkaline treatment was the selective method for lignin extraction. Vanillic acid production by Aspergillus niger I-1472 was only observed when the fermentation broth was fed with liquors from PP and PCL, possibly due to the higher levels of ferulic acid in those samples.

  3. Localized malignant pleural sarcomatoid mesothelioma misdiagnosed as benign localized fibrous tumor.

    Science.gov (United States)

    Kim, Kwan-Chang; Vo, Hong-Phuc

    2016-06-01

    Localized malignant pleural mesothelioma (LMPM) is a rare tumor with good prognosis by surgical resection. We report an atypical case of malignant pleural sarcomatoid mesothelioma (SM) in an asymptomatic 65-year-old woman, who had no history of exposure to asbestos. She presented with a small pleural mass without pleural effusion and was misdiagnosed as a benign localized fibrous tumor (BLFT) on pathologic examination through a surgical tumor specimen. However, seven months later, the patient returned with serious cancerous symptoms. A large recurrent tumor mass was found within the chest wall invading at the old surgical resection site. SM, a subtype of LMPM, was confirmed with histopathogy and immunohistochemisty. In conclusion, malignant pleural mesothelioma (MPM) can present with typical radiologic finding similar to a BLFT, and has a wide histopathologic presentation in biopsy specimen. A thorough pathologic investigation should be attempted even when a pleural mass resembles benign, localized, and small on radiologic studies.

  4. [Resection of malignant fibrous histiocytoma through a combined thoracic and abdominal wall approach].

    Science.gov (United States)

    Otsuka, T; Harada, A; Wakida, K; Aoki, M; Nagata, T; Kariatsumari, K; Sakasegawa, K; Nakamura, Y; Sato, M; Nakayama, H; Kitajima, S

    2012-05-01

    We report a case of resection of malignant fibrous histiocytoma (MFH) via combined thoracic and abdominal wall incision reconstructed using GORE DUALMESH. A 60-year-old woman underwent resection of a left lower chest wall tumor. Since the tumor infiltrated into the diaphragm, a part of the left diaphragm and left upper abdominal wall were resected together. The left chest was closed by suturing the diaphragm to the ribs. The resected area of the thoracic and abdominal wall was 12×12 cm and was reconstructed with GORE DUALMESH. She received adjuvant radiotherapy as the tumor cells were detected in the surgical margin of the diaphragm. The patient has remained well without signs of recurrence for 10 months after the operation.

  5. The Cation Exchange Capacity of Fibrous Feedstuff and Its Nutritive Characteristics

    Institute of Scientific and Technical Information of China (English)

    XING Ting-xian

    2003-01-01

    Current researches on the nutritive characteristics of fibrous feedstuff through determining thefeedstuff cation exchange capacity (CEC) to evaluate its nutritive value at home and abroad were comprehen-sively discribed, and the methods of determining CEC value and the correlation between CEC value and chemi-cal compositions, pH value, and the effect of CEC value on the digestion kinetics in ruminants were also em-phatically introduced. The results of research showed that the CEC values of different feedstuff are different,closely correlated with nitrogen and acid detergent fibre (ADF) and lignin (LIG) content of the feedstuff. Atthe same time, there are markedly effect of CEC value in diet on the nutrients flow of digesta in the digestivetract of ruminants, the degradation rate and digestibility of nutrients in the rumen.

  6. Electrocrystallization of fibrous silver deposits from nitrate melts: Experiments and modeling

    Directory of Open Access Journals (Sweden)

    Murashova I.B.

    2003-01-01

    Full Text Available Fibrous silver deposits have been obtained in molten nitrates on a moving cathode. Cylindrical silver cathode was lifted from the melt AgNO3-NaNO3-KNO3. It is found that the dimensions of the silver threads as well as their shape and thickness depend on the electrolysis parameters: the values of current and velocity of the cathode lifting. Systematic study of the silver dendrite structure has been performed on a scanning electron microscope. Geometric characteristics have been evaluated statistically and regression equations linking these constitutive properties of the deposits with the values of current and of lifting velocity have been obtained. A criterion for the description of dendrite shape under different conditions is proposed.

  7. A Hemiclamshell Incision for a Giant Solitary Fibrous Tumor of the Right Hemithorax

    Directory of Open Access Journals (Sweden)

    Nilgün Kanlıoğlu Kuman

    2012-01-01

    Full Text Available A 41-year-old female was admitted with respiratory distress. Chest radiographs showed opacity in the right hemithorax with mediastinal shift. Computed tomography (CT scan showed a pleural mass with a 22 cm diameter occupying the whole right hemithorax and causing atelectasis. Magnetic resonance imaging (MRI showed lower position of the right hemidiaphragm and the liver. Superior vena cava and heart were shifted to left. Presence of infiltration to the adjacent tissues could not be clearly evaluated because of pressure effect. Transthoracic needle biopsy specimen was reported to be benign. Because of the size and location of the mass, a hemiclamshell incision was chosen, which allowed excellent visualization and complete dissection of the giant tumor. The histopathology of the resected specimen confirmed solitary fibrous tumor. The patient was stabilized by careful observation and treatment. No complication except pneumonia in the postoperative first month occurred during the 22-month follow-up period.

  8. Effects of Contact Resistance on Heat Transfer Behaviors of Fibrous Insulation

    Institute of Scientific and Technical Information of China (English)

    Zhao Shuyuan; Zhang Boming; Du Shanyi

    2009-01-01

    In this article, a numerical model combining conduction and radiation is developed based on two flux approximation to predict the heat transfer behavior of fibrous insulation used in thermal protection systems. Monte Carlo method is utilized to determine the modified radiative properties with experimentally measured transient external temperature as high as 1 000 K. It is found that the estimated radiative properties become time-independent after about t = 3 000 s. By comparing the predicted to the measured results in transient state, the contact resistance exerts significant influences upon the temperature distribution in the specimen. Results show that the averaged absolute deviation is 3.25% when contact resistance is neglected in heat transfer model, while 1.82% with no contact resistance.

  9. Methods for determining deformation history for chocolate tablet boudinage with fibrous crystals

    Science.gov (United States)

    Casey, M.; Dietrich, D.; Ramsay, J. G.

    1983-02-01

    Chocolate tablet boudinage with fibrous crystal growths between the boudinaged plates from two localities were studied. In one, from Leytron, Valais, Switzerland, the deformation history was found to be a succession of plane strain increments with the shortening direction perpendicular to the boudinaged sheet and the extension direction showing a progressive change in orientation within the sheet. The incremental and finite strains were evaluated. The other specimen, from Parys Mountain, Anglesey Great Britain, was found to have a more complex history with diachronous break up of the competent layer and flattening strain increments. It was found that under these circumstances the direct graphical methods of determining finite and incremental strains gave inconsistent results. A numerical model was developed which allowed the simulation of chocolate tablet structure with a complex deformation history. The model was applied to the Anglesey specimen and three possible strain histories for this structure were tried.

  10. Physico-chemical Modification of the Fibrous Filter Nozzles for Purification Processes of Water and Air

    Science.gov (United States)

    Bordunov, S. V.; Galtseva, O. V.; Natalinova, N. M.; Rogachev, A. A.; Zhang, Ruizhi

    2017-01-01

    A set of experiments to study physical and chemical modification of the surface of fibers is conducted to expand the area of their application for purification of water, gas and air (including that in conditions of space). The possibility of modification of filter nozzles in the process of fiber formation by particles of coal of BAU type, copper sulfide and silver chloride is experimentally shown. The fraction of the copper sulfide powder less than 50 microns in size was crushed in a spherical mill; it was deposited on fiber at air temperature of 50° C and powder consumption of 0.5 g/l of air. The resulting material contained 6–18 CuS particles per 1 cm of the fiber length. An effective bactericidal fibrous material can be produced using rather cheap material – CuS and relatively cheap natural compounds of sulphides and oxides of heavy metals.

  11. Fibrous Filter to Protect Building Environments from Polluting Agents: A Review

    Science.gov (United States)

    Chavhan, Md. Vaseem; Mukhopadhyay, Arunangshu

    2016-04-01

    This paper discusses the use of fibrous filter to protect the building environments from air born polluting agents and especially of concern chemical, biological and radiological agents. Air-filtration includes removal of particulate from air and toxic gases from air. In air filtration, particulate which are mostly biological and radioactive types of agents can be removed by using mechanical and electrostatic filters. Some biological agents, which cannot be removed by air filtration alone, special techniques like antimicrobial finish, UV germicides, coated filters etc. are required. Biocide agent can be added into the fibre itself by grafting reaction to impart antimicrobial activity. Chemical agents like toxic gases can be removed by integrating adsorbents and sorbents in filters or by fibre modifications. It is also possible to impart catalytic conversion properties into the fibre to remove volatile gasous. Radioactive agents can be removed by particulate filter if present in the form of aerosol or by gas cleaning by the use of specific fibre impregnate.

  12. Calvarial aneurysmal bone cyst associated with fibrous dysplasia: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Harjus Birk, B.S.

    2017-03-01

    Full Text Available Aneurysmal bone cysts are benign, expansile bone lesions primary or secondary to other pathology. The majority are seen in long bones and the spine, rarely occurring within the cranial vault. Here we describe the case of a 17-year-old gentleman with McCune-Albright syndrome who developed a right parietal aneurysmal bone cyst in the setting of fibrous dysplasia. The patient was treated with lesion excision and in situ cranioplasty using methyl methacrylate and molded titanium mesh, ultimately rendering excellent cosmetic outcome. Our case report highlights the efficacy of in situ titanium cranioplasties in contouring to the native skull and enabling optimization of cosmesis, specifically through the use of titanium mesh plates with the bone flap as a template.

  13. Fibrous Dysplasia/McCune-Albright Syndrome: Clinical and Translational Perspectives.

    Science.gov (United States)

    Robinson, Cemre; Collins, Michael T; Boyce, Alison M

    2016-10-01

    Fibrous dysplasia (FD) is an uncommon and debilitating skeletal disorder resulting in fractures, deformity, functional impairment, and pain. It arises from post-zygotic somatic activating mutations in GNAS, in the cAMP-regulating transcript α-subunit, Gsα. Constitutive Gs signaling results in activation of adenylyl cyclase and dysregulated cAMP production. In the skeleton, this leads to the development of FD lesions with abnormal bone matrix, trabeculae, and collagen, produced by undifferentiated mesenchymal cells. FD may occur in isolation or in combination with extraskeletal manifestations, including hyperfunctioning endocrinopathies and café-au-lait macules, termed McCune-Albright syndrome (MAS). This review summarizes current clinical and translational perspectives in FD/MAS, with an emphasis on FD pathogenesis, natural history, pre-clinical and clinical investigation, and future directions.

  14. Dental perspectives in fibrous dysplasia and McCune-Albright syndrome.

    Science.gov (United States)

    Akintoye, Sunday O; Boyce, Alison M; Collins, Michael T

    2013-09-01

    McCune-Albright syndrome (MAS) is a rare multisystem disorder characterized by the triad of polyostotic fibrous dysplasia (FD), endocrine disorders, and café-au-lait skin pigmentation. Ninety percent of MAS patients have FD lesions in the craniofacial area, resulting in significant orofacial deformity, dental disorders, bone pain, and compromised oral health. Maxillomandibular FD is also associated with dental developmental disorders, malocclusion, and high caries index. There are limited data on the outcomes of dental treatments in maxillomandibular FD/MAS patients, because clinicians and researchers have limited access to patients, and there are concerns that dental surgery may activate quiescent jaw FD lesions to grow aggressively. This report highlights current perspectives on dental management issues associated with maxillomandibular FD within the context of MAS.

  15. Metastatic extrapleural malignant solitary fibrous tumor presenting with hypoglycemia (Doege–Potter syndrome

    Directory of Open Access Journals (Sweden)

    Andrew J. Degnan, MD, MPhil

    2017-03-01

    Full Text Available We report a rare case of metastatic malignant solitary fibrous tumor (SFT that presented with hypoglycemia because of insulin growth factor-2 production. Initial workup included computed tomography imaging that revealed a large, partially necrotic liver mass, a hypervascular pancreatic head lesion, and 2 renal lesions. Following hepatic resection, pancreatic head resection and nephrectomy, all these lesions demonstrated pathological findings that were consistent with SFT. The patient also had a history of an intracranial mass that had been previously resected and treated with gamma knife therapy at an outside institution, which was found to also be SFT. Six months after initial pancreatic head resection, the patient developed a new lesion involving the pancreatic tail that was found to represent recurrent metastatic SFT. This case emphasizes the highly aggressive nature of extrapleural SFT, while rare, and the role of imaging in follow-up for disease recurrence.

  16. Process of making titanium carbide (TiC) nano-fibrous felts

    Energy Technology Data Exchange (ETDEWEB)

    Fong, Hao; Zhang, Lifeng; Zhao, Yong; Zhu, Zhengtao

    2015-01-13

    A method of synthesizing mechanically resilient titanium carbide (TiC) nanofibrous felts comprising continuous nanofibers or nano-ribbons with TiC crystallites embedded in carbon matrix, comprising: (a) electrospinning a spin dope for making precursor nanofibers with diameters less than 0.5 J.Lm; (b) overlaying the nanofibers to produce a nanofibrous mat (felt); and then (c) heating the nano-felts first at a low temperature, and then at a high temperature for making electrospun continuous nanofibers or nano-ribbons with TiC crystallites embedded in carbon matrix; and (d) chlorinating the above electrospun nano-felts at an elevated temperature to remove titanium for producing carbide derived carbon (CDC) nano-fibrous felt with high specific surface areas.

  17. Solitary fibrous tumor of the liver expressing CD34 and vimentin: A case report

    Institute of Scientific and Technical Information of China (English)

    Dimitris P Korkolis; George N Zografos; Perikles P Vassilopoulos; Katerina Apostolaki; Chrysanthi Aggeli; George Plataniotis; Emmanuel Gontikakis; Dimitra Volanaki; Maria Sebastiadou; Dimitris Dimitroulopoulos; Dimitris Xinopoulos

    2008-01-01

    A case of a successfully treated solitary fibrous tumor(SFT) of the liver is reported. An 82-year-old femalepresented with left upper abdominal discomfort, afirm mass on palpation, and imaging studies revealeda large tumor, 15 cm in diameter, arising from theleft lobe of the liver. A formal left hepatectomy wasperformed. Microscopic evaluation showed spindleand fibroblast-like cells within the collagenous stroma.Immunohistochemistry disclosed diffuse CD34 andpositive vimentin, supporting the diagnosis of abenign SFT. The patient remained well 21 monthsafter surgery. SFT of the liver is a very rare neoplasmof mesenchymal origin. In most cases it is a benignlesion, although some may have malignant histologicalfeatures and recur locally or metastasize. With lessthan 30 reported cases in the literature, little canbe said regarding its natural history or the benefitsof adjuvant radiochemotherapy. Complete surgicalresection remains the cornerstone of its treatment.

  18. A case of primary malignant fibrous histiocytoma of the pancreas with liver metastasis

    Institute of Scientific and Technical Information of China (English)

    Wenlong Zhai; Jianwen Ye; Zhiwei Liang; Chuang Zhou; Longshuan Zhao

    2015-01-01

    Malignant fibrous histiocytoma (MFH) is one of most common types of soft-tissue sarcoma. However, it accounts for less than 1% of al human cancer types. In addition, primary MFH of the pancreas is very rare. Herein, we report of a 37-year-old man who presented with a pancreatic mass and did not show any specific symptoms. Pre-contrast computed tomography (CT) showed a heterogeneous, liquid-filed necrotic mass in the uncinate lobe of the pancreas. Contrast-enhanced CT showed a mild enhancement of solid components and the pancreaticoduodenal artery across the mass. The patient underwent a pancreatico-duodenectomy, ethanol ablation of the liver lesions, and chemotherapy with 4 cycles of ifosfamide and doxorubicin. The tumor recurred in the liver, but not in the pancreas, after 8 months.

  19. A Study on Nanoparticle Aerosol Filtration via Different Fibrous Filters by Using CFD Approach

    Institute of Scientific and Technical Information of China (English)

    Q. Wang; B. Maze; H. Vahedi Tafreshi; B. Pourdeyhimi

    2006-01-01

    Fibrous filters such as nonwoven media are generally characterized by their collection efficiency and pressure drop. The traditional computational studies in this area typically based on unrealistic over-simplified geometries with the fibers placed in a lattice perpendicular to the flow.This paper describes the filter properties made of different Nonwoven materials by using Computational Fluid Dynanics (CFD) approach. In this study, for the first time, a virtual 3 - D web is generated based on the fiber orientation information obtaining from analyzing microscopic images of both long-fiber and short-fiber nonwoven structures. Pressure drop and collection efficiency of our virtual filter are simulated and compared with the previous analytical and numerical models as well as experiment.

  20. Dental Perspectives in Fibrous Dysplasia and McCune-Albright Syndrome

    Science.gov (United States)

    Akintoye, Sunday O.; Boyce, Alison M.; Collins, Michael T.

    2013-01-01

    McCune-Albright syndrome (MAS) is a rare multisystem disorder characterized by the triad of polyostotic fibrous dysplasia (PFD), endocrine disorders and café-au-lait skin pigmentation. Ninety percent of MAS patients have FD lesions in the craniofacial area, resulting in significant orofacial deformity, dental disorders, bone pain and compromised oral health. Maxillo-mandibular FD is also associated with dental developmental disorders, malocclusion, and high caries index. There is limited data on the outcomes of dental treatments in maxillo-mandibular FD/MAS patients, because clinicians and researchers have limited access to patients, and there are concerns that dental surgery may activate quiescent jaw FD lesions to grow aggressively. This report highlights current perspectives on dental management issues associated with maxillo-mandibular FD within the context of MAS. PMID:23953425

  1. Antibacterial activities of surface modified electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) fibrous membranes

    Science.gov (United States)

    Yao, Chen; Li, Xinsong; Neoh, K. G.; Shi, Zhilong; Kang, E. T.

    2009-01-01

    Poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) membrane, with its excellent chemical and mechanical properties, has good potential for broad applications. However, due to its hydrophobic nature, microbial colonization is commonly encountered. In this work, electrospun PVDF-HFP fibrous membranes were surface modified by poly(4-vinyl- N-alkylpyridinium bromide) to achieve antibacterial activities. The membranes were first subjected to plasma pretreatment followed by UV-induced surface graft copolymerization of 4-vinylpyridine (4VP) and quaternization of the grafted pyridine groups with hexylbromide. The chemical composition of the surface modified PVDF-HFP electrospun membranes was studied by X-ray photoelectron spectroscopy (XPS). The morphology and mechanical properties of pristine and surface modified PVDF-HFP fibrous membranes were characterized by scanning electron microscopy (SEM) and tensile test, respectively. The antibacterial activities of the modified electrospun PVDF-HFP fibrous membranes were assessed against Gram-positive Staphylococcus aureus ( S. aureus) and Gram-negative Escherichia coli ( E. coli). The results showed that the PVDF-HFP fibrous membranes modified with quaternized pyridinium groups are highly effective against both bacteria with killing efficiency as high as 99.9999%.

  2. Antibacterial activities of surface modified electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) fibrous membranes

    Energy Technology Data Exchange (ETDEWEB)

    Yao Chen [School of Chemistry and Chemical Engineering, Southeast University, Sipailou 2, Nanjing 210018 (China); Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent, Ridge, 119260 Singapore (Singapore); Li Xinsong [School of Chemistry and Chemical Engineering, Southeast University, Sipailou 2, Nanjing 210018 (China)], E-mail: lixs@seu.edu.cn; Neoh, K.G. [Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent, Ridge, 119260 Singapore (Singapore)], E-mail: chenkg@nus.edu.sg; Shi Zhilong; Kang, E.T. [Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent, Ridge, 119260 Singapore (Singapore)

    2009-01-01

    Poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) membrane, with its excellent chemical and mechanical properties, has good potential for broad applications. However, due to its hydrophobic nature, microbial colonization is commonly encountered. In this work, electrospun PVDF-HFP fibrous membranes were surface modified by poly(4-vinyl-N-alkylpyridinium bromide) to achieve antibacterial activities. The membranes were first subjected to plasma pretreatment followed by UV-induced surface graft copolymerization of 4-vinylpyridine (4VP) and quaternization of the grafted pyridine groups with hexylbromide. The chemical composition of the surface modified PVDF-HFP electrospun membranes was studied by X-ray photoelectron spectroscopy (XPS). The morphology and mechanical properties of pristine and surface modified PVDF-HFP fibrous membranes were characterized by scanning electron microscopy (SEM) and tensile test, respectively. The antibacterial activities of the modified electrospun PVDF-HFP fibrous membranes were assessed against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). The results showed that the PVDF-HFP fibrous membranes modified with quaternized pyridinium groups are highly effective against both bacteria with killing efficiency as high as 99.9999%.

  3. A reappraisal of hemangiopericytoma of bone; analysis of cases reclassified as synovial sarcoma and solitary fibrous tumor of bone

    DEFF Research Database (Denmark)

    Verbeke, Sofie L J; Fletcher, Christopher D M; Alberghini, Marco

    2010-01-01

    Hemangiopericytoma (HPC) was first described as a neoplasm with distinct morphologic features, presumably composed of pericytes. In soft tissue, it is accepted that most such lesions are solitary fibrous tumors (SFTs), monophasic synovial sarcomas (SSs), or myofibromatoses. It is unclear whether...

  4. Attenuation coefficients for fibrous self-compacting concrete in the energy range of 50-3000 keV

    Energy Technology Data Exchange (ETDEWEB)

    Bento, W.V.; Magalhaes, L.A.M.; Conti, C.C., E-mail: ccconti@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2017-04-01

    The fibrous self-compacting concrete is a high performance concrete with uniformly distributed iron fibers. Transmission measurements, with {sup 137}Cs and {sup 60}Co sources were performed for the attenuation coefficients determination for both ordinary and fibrous self-compacting concretes. The results were compared to each other and to the values found in the literature for ordinary concrete. The mass attenuation coefficient for the fibrous self-compacting concrete showed to be higher than those for ordinary concrete of about 5%, depending on the gamma energy. However, it should be noted that the density of fibrous self-compacting concrete is higher than ordinary concrete, 2.4 g/cm{sup 3} and 1.9 g/cm{sup 3} respectively, increasing still further the difference in mass attenuation coefficient. In addition to that, by using Monte Carlo simulations, with MCNP5 Monte Carlo computer code, the data was extended to the 50-3000 keV gamma energy range. (author)

  5. Deep benign fibrous histiocytoma: computed tomography and histology findings; Histiocitoma fibroso benigno profundo: achados na tomografia computadorizada e histologia

    Energy Technology Data Exchange (ETDEWEB)

    Farage, Luciano; Castro, Mario Augusto Padula; Macedo, Tulio Augusto Alves [Uberlandia Univ., MG (Brazil). Hospital das Clinicas. Setor de Radiologia; Salomao, Eliana Chaves; Machado, Tania Alcantara; Souza, Lincoln Pereira de; Freitas, Luiz de Oliveira [Uberlandia Univ., MG (Brazil). Faculdade de Medicina. Dept. de Clinica Medica

    2005-04-01

    We present the computed tomography images of an 83-year-old male patient with a deep benign fibrous histiocytoma at the lateral aspect of the left leg. Computed tomography images showed a well-defined mass with marked peripheral enhancement by iodinated contrast medium. Only few reports of this rare soft tissue tumor can be found in the literature. (author)

  6. Heparin as a Bundler in a Self-Assembled Fibrous Network of Functionalized Protein-Based Polymers

    NARCIS (Netherlands)

    Wlodarczyk-Biegun, Gosia; Slingerland, Cornelis J.; Werten, Marc W.T.; Hees, van Ilse A.; Wolf, de Frits A.; Vries, de Renko; Cohen Stuart, Martien; Kamperman, Marleen

    2016-01-01

    Nature shows excellent control over the mechanics of fibrous hydrogels by assembling protein fibers into bundles of well-defined dimensions. Yet, obtaining artificial materials displaying controlled bundling remains a challenge. Here, we developed genetically engineered protein-based polymers

  7. Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis.

    Science.gov (United States)

    Wu, Di; Hiroshima, Kenzo; Matsumoto, Shinji; Nabeshima, Kazuki; Yusa, Toshikazu; Ozaki, Daisuke; Fujino, Michio; Yamakawa, Hisami; Nakatani, Yukio; Tada, Yuji; Shimada, Hideaki; Tagawa, Masatoshi

    2013-01-01

    The distinction between sarcomatoid mesothelioma and fibrous pleuritis is difficult based on histology, especially when the amount of tumor tissue examined via biopsy is small and immunohistochemical examination is inconclusive. We studied the usefulness of deletion of p16 with fluorescence in situ hybridization (FISH) and p16 hypermethylation with polymerase chain reaction for the diagnosis and prognosis of malignant pleural mesothelioma (MPM). We analyzed 50 MPMs, including 22 sarcomatoid mesothelioma cases and 10 fibrous pleuritis cases. We set the cutoff value of homozygous deletion pattern as 14.4% based on FISH signaling patterns using samples of fibrous pleuritis. The percentage of homozygous deletion pattern was higher than 14.4% in 55.6% of the epithelioid mesotheliomas (10/18) and in all of the sarcomatoid mesotheliomas (22/22). Methylation of p16 was observed in 7 (20.6%) of 34 informative cases. p16 FISH analysis can be a reliable test for distinguishing between sarcomatoid mesothelioma and fibrous pleuritis and a prognostic factor for MPM.

  8. McCune Albright syndrome - association of fibrous dysplasia, café-au-lait skin spots and hyperthyroidism - case report.

    Science.gov (United States)

    Raus, Iulian; Coroiu, Roxana Elena

    2016-01-01

    McCune-Albright syndrome is a rare sporadic disease characterized by bone fibrous dysplasia, café-au-lait skin spots and a variable association of hyperfunctional endocrine disorders. Fibrous dysplasia (FD), which can involve the craniofacial, axial, and appendicular skeleton, may range from an isolated, asymptomatic monostotic lesion to a severe disabling polyostotic disease involving the entire skeleton. A twenty-five-year old male patient presented to our clinic with recently developed heart palpitations. He had also been feeling pain in the right femur since he was younger, without any trauma history, leading to difficulties of ambulation and limping occasionally. His physical examination revealed café-au-lait spots with irregular borders and right testicular agenesis. Laboratory findings identified hyperthyroidism with hyperparathyroidism. Radiographs of the pelvis revealed multiple lytic lesions of the right femur and magnetic resonance imaging (MRI) characterized these lesions as specific to fibrous dysplasia of the bone, without any insufficiency fracture at this level. The association of café-au-lait skin spots with bone fibrous dysplasia, and hyperthyroidism in this patient suggested the diagnosis of McCune - Albright syndrome.

  9. Osteosarcoma of the mandible arising de novo in fibrous dysplasia. Case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Aikaterine TRIANTAFILLIDOU, Konstantinos PSOMADERIS, Fotis IORDANIDIS, Dimitris KARAKASIS

    2012-04-01

    Full Text Available SUMMARY: Introduction: Malignant transformation of fibrous dysplasia is rare, accounting 4% of cases with McCune-Albright syndrome and 0,5% of monostotic type.Case presentation: An 11-year old boy presented with hard swelling and disfigurement of his mandible in conjunction with alterations of his dental occlusion. Following biopsy, fibrous dysplasia was diagnosed. The patient underwent surgical contouring of the affected bone. Four years later a fast growing mass developed at the same site of the operated mandible. After an incisional biopsy the diagnosis of low-grade osteosarcoma was established. The patient underwent wide mandibulectomy and reconstruction of the defect with bonegraft and is free of the disease for the last 14 years.Conclusion: Most cases of malignant transformation of FD are associated with irradiation of the fibrous dysplasia.The spontaneous transformation of the monostotictype is extremely rare. The development of a soft tissue mass or elevation of serum alkaline phosphatase in a patient with fibrous dysplasia should be considered alarming features and require further investigation to exclude sarcoma.

  10. Transanal excision of a malignant fibrous histiocytoma of anal canal:A case report and literature review

    Institute of Scientific and Technical Information of China (English)

    Beom Gyu Kim; In Taik Chang; Jun Seok Park; Yoo Shin Choi; Gi Hyeon Kim; Eon Sub Park; Chang Hwan Choi

    2008-01-01

    Malignant fibrous histiocytoma,which is composed of spindle-shaped cells arranged in a pleomorphic and storiform pattern,is rarely found in the colorectum.Although complete surgical excision remains the main stem of therapy,an optimal treatment strategy according to the stage has not been elucidated.We report a case of a 63-year-old woman with an ulcerative lesion in the anorectal junction and a final diagnosis of malignant fibrous histiocytoma.We introduced an access for transanal local excision and adjuvant radiotherapy because the patient refused abdominoperineal resection.No local recurrences or distant metastases were observed 15 mo after the operation.To our knowledge,this is the first case reported in the English literature of a malignant fibrous histiocytoma treated with the transanal local excision and adjuvant radiotherapy.This report showed that this approach is selectively reserved for early-stage malignant fibrous histiocytoma and for those patients who refuse radical surgery because of the risk in a permanent colostomy.

  11. Chiral front propagation in liquid-crystalline materials: Formation of the planar monodomain twisted plywood architecture of biological fibrous composites.

    Science.gov (United States)

    De Luca, Gino; Rey, Alejandro D

    2004-01-01

    Biological fibrous composites commonly exhibit an architecture known as twisted plywood, which is similar to that of the cholesteric liquid-crystalline mesophases. The explanation for the structural similarity is that biological fibrous composites adopt a lyotropic cholesteric liquid-crystalline phase during their formation process. In this work, a mathematical model based on the Landau-de Gennes theory of liquid crystals has been developed to reproduce the process by which long chiral fibrous molecules form the twisted plywood structures observed in biological composites. The dynamics of the process was then further investigated by analytically solving a simplified version of the governing equations. Results obtained from the model are in good qualitative agreement with the theory of Neville [Biology of Fibrous Composites (Cambridge University Press, Cambridge, England, 1993)] who hypothesized the necessity of a constraining layer to lock the direction of the helical axis of the plywood in order to create a monodomain structure. Computational results indicate that the plywood architecture is obtained by a chiral front propagation process with a fully relaxed wake. The effects of chirality and concentration on the formation process kinetics are characterized.

  12. Biodegradable fibrous scaffolds with tunable properties formed from photo-cross-linkable poly(glycerol sebacate).

    Science.gov (United States)

    Ifkovits, Jamie L; Devlin, Jeffrey J; Eng, George; Martens, Timothy P; Vunjak-Novakovic, Gordana; Burdick, Jason A

    2009-09-01

    It is becoming increasingly apparent that the architecture and mechanical properties of scaffolds, particularly with respect to mimicking features of natural tissues, are important for tissue engineering applications. Acrylated poly(glycerol sebacate) (Acr-PGS) is a material that can be cross-linked upon exposure to ultraviolet light, leading to networks with tunable mechanical and degradation properties through simple changes during Acr-PGS synthesis. For example, the number of acrylate functional groups on the macromer dictates the concentration of cross-links formed in the resulting network. Three macromers were synthesized that form networks that vary dramatically with respect to their tensile modulus ( approximately 30 kPa to 6.6 MPa) and degradation behavior ( approximately 20-100% mass loss at 12 weeks) based on the extent of acrylation ( approximately 1-24%). These macromers were processed into biodegradable fibrous scaffolds using electrospinning, with gelatin as a carrier polymer to facilitate fiber formation and cell adhesion. The resulting scaffolds were also diverse with respect to their mechanics (tensile modulus ranging from approximately 60 kPa to 1 MPa) and degradation ( approximately 45-70% mass loss by 12 weeks). Mesenchymal stem cell adhesion and proliferation on all fibrous scaffolds was indistinguishable from those of controls. The scaffolds showed similar diversity when implanted on the surface of hearts in a rat model of acute myocardial infarction and demonstrated a dependence on the scaffold thickness and chemistry in the host response. In summary, these diverse scaffolds with tailorable chemical, structural, mechanical, and degradation properties are potentially useful for the engineering of a wide range of soft tissues.

  13. Solitary fibrous tumors of the central nervous system: clinical features and imaging findings in 22 patients.

    Science.gov (United States)

    Wang, Xiao-Qiang; Zhou, Qing; Li, Shi-Ting; Liao, Chen-Long; Zhang, Hua; Zhang, Bi-Yun

    2013-01-01

    Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm originating in the central nervous system (CNS), with imaging features currently not well known. The purposes were to describe and characterize clinical features and imaging findings of CNS SFT. We retrospectively reviewed computed tomographic (CT; n = 10) and magnetic resonance (MR) images (n = 18) of 22 patients with SFT (13 males and 9 females; mean, 47.6 years) with associated clinical records. Each lesion was found as a solitary, well-defined mass, ranging in size from 12 to 70 mm (mean, 38 mm). The tumor shape was roundlike in 16 cases (72.7%) and irregular in 6 cases (27.2%). The cerebellopontine angle zone was the most affected area (n = 6). On precontrast CT scans, 10 cases showed predominantly hyperattenuation (n = 9) and isoattenuation (n = 1). No lesion contained calcification, and 2 cases showed bone invasions. All 18 tumors examined by MR imaging showed homogeneous hypointensive (n = 5) or isointensive (n = 7) signal intensity and heterogeneous mixed isointense and hypointense signal intensity (n = 6) on T1-weighted images, whereas most tumors were predominantly isointense (n = 13) and hypointense (n = 4) to the cortex on T2-weighted images; on postcontrast CT and MR images, enhancement was marked homogeneous (n = 10) or heterogeneous (n = 12). Fourteen tumors had thickening of the meninges adjacent to the tumor. Although SFT is a rare neoplasm in the CNS, it should be considered in the differential diagnosis. The most affected area is the cerebellopontine angle zone. Solitary fibrous tumor tends to have some imaging features, such as high attenuation on CT, isointense to hypointense signal intensity on MR images, and marked enhancement.

  14. Myxoid Type of Malignant Fibrous Histiocytoma of the Maxillary Sinus: A Case Report

    Directory of Open Access Journals (Sweden)

    Amir Hossein Jafarian

    2011-04-01

    Full Text Available Introduction: Myxofibrosarcoma was originally described as the myxoid variant of Malignant Fibrous Histiocytoma (MFH, a high-grade and aggressive sarcoma, which is very uncommon in the head and neck region, with about 100 cases reported up to now. MFH occurring in the maxillary sinus is so rare that only 23 cases have been reported. We hereby report a case of myxofibrosarcoma in the maxillary sinus. Case Report: The case was a 54-year-old male with symptoms of toothache in the right posterior maxillary teeth, a swelling adjacent to maxillary molar region and symptoms of chronic maxillary sinusitis. In clinical examination, the teeth were sensitive to percussion and palpation, but no caries and restoration was detected on his molar teeth. He was suffering from local pain and tenderness over his midface and mild fever, fatigue and some nonspecific vague pain. CT scan showed a mass lesion involving right nasal cavity, maxillary and ethmoidal sinuses. A low-grade malignancy arising from the right maxillary sinus was highly suspected. A surgery was done to remove the mass. The histological and immunohistochemical studies proved the diagnosis of myxoid variant of Malignant Fibrous Histiocytoma. Therefore radiotherapy and chemotherapy was started for the patient but six months later the symptoms returned and CT scan showed a right maxillary and ethmoidal mass that extended to base of the skull. Maxillectomy and ethmoidectomy were performed for the patient, but 2 months later he died because of the extension of the tumor, which confirmed the necessity of early diagnosis. Conclusion: Amplified radical surgery is the first choice of treatment. The second surgery has special value to the recurrent patients. Radiotherapy alone or chemotherapy alone is not effective to MFH of head and neck region

  15. Retrospective Analysis of NIST Standard Reference Material 1450, Fibrous Glass Board, for Thermal Insulation Measurements.

    Science.gov (United States)

    Zarr, Robert R; Heckert, N Alan; Leigh, Stefan D

    2014-01-01

    Thermal conductivity data acquired previously for the establishment of Standard Reference Material (SRM) 1450, Fibrous Glass Board, as well as subsequent renewals 1450a, 1450b, 1450c, and 1450d, are re-analyzed collectively and as individual data sets. Additional data sets for proto-1450 material lots are also included in the analysis. The data cover 36 years of activity by the National Institute of Standards and Technology (NIST) in developing and providing thermal insulation SRMs, specifically high-density molded fibrous-glass board, to the public. Collectively, the data sets cover two nominal thicknesses of 13 mm and 25 mm, bulk densities from 60 kg·m(-3) to 180 kg·m(-3), and mean temperatures from 100 K to 340 K. The analysis repetitively fits six models to the individual data sets. The most general form of the nested set of multilinear models used is given in the following equation: [Formula: see text]where λ(ρ,T) is the predicted thermal conductivity (W·m(-1)·K(-1)), ρ is the bulk density (kg·m(-3)), T is the mean temperature (K) and ai (for i = 1, 2, … 6) are the regression coefficients. The least squares fit results for each model across all data sets are analyzed using both graphical and analytic techniques. The prevailing generic model for the majority of data sets is the bilinear model in ρ and T. [Formula: see text] One data set supports the inclusion of a cubic temperature term and two data sets with low-temperature data support the inclusion of an exponential term in T to improve the model predictions. Physical interpretations of the model function terms are described. Recommendations for future renewals of SRM 1450 are provided. An Addendum provides historical background on the origin of this SRM and the influence of the SRM on external measurement programs.

  16. [Asbestos-related diseases in a population near a fibrous cement factory].

    Science.gov (United States)

    Tarrés, Josep; Abós-Herràndiz, Rafael; Albertí, Constança; Martínez-Artés, Xavier; Rosell-Murphy, Magdalena; García-Allas, Isabel; Krier, Illona; Castro, Emilia; Cantarell, Gloria; Gallego, Miguel; Orriols, Ramón

    2009-09-01

    The first fibrous cement factory in Spain was set up in Cerdanyola, Barcelona, in 1907 and was a source of pollution there until it was closed in 1997. The aim of this study was to determine the clinical and epidemiologic characteristics of the population with by asbestos-related diseases who had worked in the factory and/or lived in the vicinity. We retrospectively collected information available on patients with asbestos-related diseases who at the time of diagnosis had resided in the area near the fibrous cement factory. Information was obtained from the medical records of the primary care centers of the 12 surrounding towns and the sole referral hospital in the area for cases diagnosed between January 1, 1970 and December 31, 2006. In the 559 patients diagnosed, 1107 cases of asbestos-related diseases were identified. Between 2000 and 2006, the average annual incidence was 9.5 cases per 100,000 inhabitants for the entire study area and 35.5 cases per 100,000 for the area nearest the factory. The prevalence of asbestos-related diseases as of December 31, 2006 was 91 cases per 100,000 inhabitants in the entire study area and 353.4 cases per 100,000 in the area nearest the factory. Of the 1107 asbestos-related disease cases identified, 86.5% were benign and 8.4% pleural mesothelioma. The factory introduced an important area-wide risk factor for asbestos-related diseases for both workers and for the nearby population. The number of cases of asbestos-related diseases detected annually showed an upward trend. The incidence was extremely high in the period studied.

  17. Electrospinning of multicomponent ultrathin fibrous nonwovens for semi-occlusive wound dressings.

    Science.gov (United States)

    Hong, Youliang; Li, Yanan; Zhuang, Xiuli; Chen, Xuesi; Jing, Xiabin

    2009-05-01

    This work describes the design and assembly of multifunctional and cost-efficient composite fiber nonwovens as semi-occlusive wound dressings using a simple electrospinning process to incorporate a variety of functional components into an ultrathin fiber. These components include non-hydrophilic poly(L-lactide) (PLLA) as fibrous backbone, hydrophilic poly(vinyl pyrrolidone)-iodine (PVP-I), TiO(2) nanoparticles, zinc chloride as antimicrobial, odor-controlling, and antiphlogistic agents, respectively. The process of synthesis starts with a multicomponent solution of PLLA, PVP, TiO(2) nanoparticles plus zinc chloride, in which TiO(2) nanoparticles are synthesized by in situ hydrolysis of TiO(2) precursors in a PVP solution for the sake of obtaining the particle-uniformly dispersive solution. Subsequent electrospinning generates the corresponding composite fibers. A further iodine vapor treatment to the composite fibers combines iodine with PVP to produce the PVP-I complexes. Experiments indicate that the assembled composite fibers (300-400 nm) possess the ointment-releasing characteristic and the phase-separate, core-sheath structures in which PVP-I residing in fiber surface layer becomes the sheath, and PLLA distributing inside the fiber acts as the core. Based on this design, the structural advantages combining active components endow the assembled composite nonwovens with a variety of functions, especially, the existence of PVP-I, endows the nonwoven with water absorbability, antimicrobial activity, adhesive ability, and transformable characteristic from hydrophilicity to non-hydrophilicity. The multifunctional, cost-efficient, and ointment-releasing characteristics make the multicomponent composite fibrous nonwovens potentially useful in applications such as initial stage of dressing of the cankerous or contaminated wounds.

  18. Fibrohistiocitoma benigno ósseo na coluna lombar Benign fibrous histiocytoma of the lumbar spine

    Directory of Open Access Journals (Sweden)

    Osmar Avanzi

    2005-01-01

    Full Text Available CONTEXTO: O fibrohistiocitoma benigno intra-ósseo é uma neoplasia rara, caracterizada por proliferação fibroblástica e fibras colágenas. A dor na região lombar é uma queixa freqüente em muitos pacientes, mas, na maioria das vezes está relacionada com causa muscular ou degenerativa. RELATO DE CASO: Relata-se aqui o caso de um paciente com diagnóstico de fibrohistiocitoma benigno ósseo na coluna lombar que apresentava queixa de lombalgia há cinco meses antes do diagnóstico. Foi submetida à biópsia aberta transpedicular na quarta vértebra lombar ,e, posteriormente realizada curetagem da lesão via anterior retroperitonial e artrodese vertebral de L3-L5 com enxerto de fíbula. CONCLUSÃO: Apesar de raro, o fibrohistiocitoma benigno intra-ósseo deve ser uma das hipóteses quando observamos uma lesão primária na coluna vertebral.CONTEXT: Benign intraosseous fibrous histiocytoma is a rare neoplasia, characterized by fibroblastic and collagenous fiber proliferation. Pain in the lumbar region is a frequent complaint in many patients, but most of times it is associated to muscular or degenerative causes. CASE REPORT: Here we report a case of a patient diagnosed with benign bone fibrous histiocytoma in the lumbar spine who complained of lumbar pain dating five months prior to diagnosis. The patient was submitted to open transpedicular biopsy in the forth lumbar vertebra, and subsequently, lesion curettage was performed via anterior retroperitoneal and L3-L5 vertebral arthrodesis using a fibular graft. CONCLUSION: Although rare, benign intraosseous fibrohistiocytoma should be taken into consideration when a primary lesion is observed in the spine.

  19. Promotion of initial anti-tumor effect via polydopamine modified doxorubicin-loaded electrospun fibrous membranes

    Science.gov (United States)

    Yuan, Ziming; Zhao, Xin; Wang, Xiaohu; Qiu, Wangwang; Chen, Xinliang; Zheng, Qi; Cui, Wenguo

    2014-01-01

    Drug-loaded electrospun PLLA membranes are not conducive to adhesion between materials and tissues due to the strong hydrophobicity of PLLA, which possibly attenuate the drugs’ effect loaded on the materials. In the present work, we developed a facile method to improve the hydrophilicity of doxorubicin (DOX)-loaded electrospun PLLA fibrous membranes, which could enhance the anti-tumor effect at the early stage after implantation. A mussel protein, polydopamine (PDA), could be easily grafted on the surface of hydrophobic DOX-loaded electrospun PLLA membranes (PLLA-DOX/pDA) in water solution. The morphology analysis of PLLA-DOX/pDA fibers displayed that though the fiber diameter was slightly swollen, they still maintained a 3D fibrous structure, and the XPS analysis certified that pDA had successfully been grafted onto the surface of the fibers. The results of surface wettability analysis showed that the contact angle decreased from 136.7° to 0° after grafting. In vitro MTT assay showed that the cytotoxicity of PLLA-DOX/pDA fibers was the strongest, and the stereologic cell counting assay demonstrated that the adhesiveness of PLLA/pDA fiber was significantly better than PLLA fiber. In vivo tumor-bearing mice displayed that, after one week of implantation, the tumor apoptosis and necrosis of PLLA-DOX/pDA fibers were the most obvious from histopathology and TUNEL assay. The caspase-3 activity of PLLA-DOX/pDA group was the highest using biochemical techniques, and the Bax: Bcl-2 ratio increased significantly in PLLA-DOX/pDA group through qRT-PCR analysis. All the results demonstrated that pDA can improve the affinity of the electrospun PLLA membranes and enhance the drug effect on tumors. PMID:25337186

  20. Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature

    Directory of Open Access Journals (Sweden)

    Mearini E

    2014-05-01

    Full Text Available Ettore Mearini,1 Giovanni Cochetti,1 Francesco Barillaro,1 Sonia Fatigoni,2 Fausto Roila2 1Department of Medical-Surgical Specialties and Public Health, Division of Urological Andrological Surgery and Minimally Invasive Techniques, University of Perugia, Terni, Italy; 2Medical Oncology, S Maria Hospital, Terni, Italy Abstract: Solitary fibrous tumors are rare mesenchymal spindle cell neoplasms that are usually found in the pleura. The kidneys are an uncommon site and only few cases of renal solitary fibrous tumor exhibit malignant behavior metastasizing to the liver, lung, and bone through the hematogenous pathway. Purpose: To describe the first case of lymph node metastasis from renal solitary fibrous tumor in order to increase the knowledge about the malignant behavior of these tumors. Patients and methods: A 19-year-old female patient had intermittent hematuria for several months without flank pain or other symptoms. A chest and abdomen CT scan was performed and showed a multi-lobed bulky solid mass of 170 × 98 × 120 mm in the left kidney. One day before the surgery, the left renal artery was catheterized and the kidney embolization was performed using a Haemostatic Absorbable Gelatin Sponge and polyvinyl alcohol. We then performed a radical nephrectomy with hilar, para-aortic, and inter-aortocaval lymphadenectomy. Results: Estimated intraoperative blood loss was 200 mL and the operative time was 100 minutes. No postoperative complications occurred. The hospital stay was 7 days long. The histological examination was malignant solitary fibrous tumor of the kidney. Cancerous tissue showed cellular atypia, with an increased mitotic index (up to 7 × 10 hpf. Immunohistochemical analysis showed positive results for CD34, BCL2, partial expression of HBME1, and occasionally of synaptophysin. Histological evaluation confirmed the presence of metastasis in one hilar node. The patient did not receive any other therapy. At 30-month follow-up, the

  1. Quaternized chitosan/κ-carrageenan/caffeic acid-coated poly(3-hydroxybutyrate) fibrous materials: Preparation, antibacterial and antioxidant activity.

    Science.gov (United States)

    Ignatova, Milena; Manolova, Nevena; Rashkov, Iliya; Markova, Nadya

    2016-11-20

    Novel fibrous materials with antioxidant and antibacterial properties from poly(3-hydroxybutyrate) (PHB), quaternized chitosan (QCh), κ-carrageenan (Car) and caffeic acid (CA) were obtained. These materials were prepared by applying electrospinning or electrospinning in conjunction with dip-coating and polyelectrolyte complex (PEC) formation. It was found that the CA release depended on the fiber composition. X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC) revealed that CA incorporated in the fibers was in the amorphous state, whereas CA included in the coating was in the crystalline state. In contrast to the neat PHB mats, the CA-containing mats and the PEC QCh/Car-coated mats were found to kill the Gram-positive bacteria S. aureus and the Gram-negative bacteria E. coli and were effective in suppressing the adhesion of pathogenic bacteria S. aureus. Enhancement of the antioxidant activity of the fibrous materials containing both CA and QCh/Car coating was observed.

  2. Electrospun Aligned Fibrous Arrays and Twisted Ropes: Fabrication, Mechanical and Electrical Properties, and Application in Strain Sensors

    Science.gov (United States)

    Zheng, Jie; Yan, Xu; Li, Meng-Meng; Yu, Gui-Feng; Zhang, Hong-Di; Pisula, Wojciech; He, Xiao-Xiao; Duvail, Jean-Luc; Long, Yun-Ze

    2015-12-01

    Electrospinning (e-spinning) is a versatile technique to fabricate ultrathin fibers from a rich variety of functional materials. In this paper, a modified e-spinning setup with two-frame collector is proposed for the fabrication of highly aligned arrays of polystyrene (PS) and polyvinylidene fluoride (PVDF) nanofibers, as well as PVDF/carbon nanotube (PVDF/CNT) composite fibers. Especially, it is capable of producing fibrous arrays with excellent orientation over a large area (more than 14 cm × 12 cm). The as-spun fibers are suspended and can be easily transferred to other rigid or flexible substrates. Based on the aligned fibrous arrays, twisted long ropes are also prepared. Compared with the aligned arrays, twisted PVDF/CNT fiber ropes show enhanced mechanical and electrical properties and have potential application in microscale strain sensors.

  3. Physical-chemical studies of proteins of squid nerve axoplasm, with special reference to the axon fibrous protein.

    Science.gov (United States)

    DAVISON, P F; TAYLOR, E W

    1960-03-01

    The proteins in the axoplasm of the squid, Dosidicus gigas, have been resolved electrophoretically into a major fraction including the fibrous protein, and possibly its structural subunits, and a minor fraction including at least two proteins with low sedimentation coefficients. A partially reversible change in the structure of the fibrous protein occurs under the action of 0.4 M salt or high pH. These experiments have been interpreted to indicate that in the intact fiber one, or a few, protofibrils are arranged helically or longitudinally along the fiber axis, and linked by electrostatic bonds. On the dissociation of these bonds the separated protofibrils assume a less extended form and sediment more rapidly than the intact fibers. Some material with a lower sedimentation rate is also released on the dissociation. This fraction may comprise smaller chain fragments. The volume fraction and the approximate refractive index of the fibers have been calculated.

  4. Odontogenic Sinusitis Caused by an Inflammation of a Dentigerous Cyst and Subsequent Finding of a Fibrous Dysplasia. A Case Report

    Science.gov (United States)

    López-Carriches, Carmen; López-Carriches, Inmaculada; Bryan, Rafael Baca-Perez

    2016-01-01

    We report the case of a 38-year old male patient with sinusitis caused by an infected follicular cyst due to an ectopic impacted third molar in the right maxillary sinus. A 10-day antibiotherapy regimen was administered; subsequently, the cyst and the third molar were removed achieving complete recovery. Fibrous dysplasia was diagnosed at follow-up examination (occupation of the maxillary sinus by bone tissue was observed in a radiographic examination) and confirmed by biopsy. In cases of odontogenic sinusitis, thorough examination is crucial, as evidenced by the case reported in this study. A Literature review was performed in order to identify the diagnostic methods currently available and the clinical features, complications and treatment for both, odontogenic maxillary sinusitis and fibrous dysplasia. PMID:28077969

  5. General Deposition of Metal-Organic Frameworks on Highly Adaptive Organic-Inorganic Hybrid Electrospun Fibrous Substrates.

    Science.gov (United States)

    Liu, Chang; Wu, Yi-Nan; Morlay, Catherine; Gu, Yifan; Gebremariam, Binyam; Yuan, Xiao; Li, Fengting

    2016-02-01

    Electrospun nanofibrous mats are ideal substrates for metal-organic frameworks (MOFs) crystal deposition because of their specific structural parameters and chemical tenability. In this work, we utilized organic-inorganic hybrid electrospun fibrous mats as support material to study the deposition of various MOF particles. HKUST-1 and MIL-53(Al) were produced through solvothermal method, while ZIF-8 and MIL-88B(Fe) were prepared using microwave-induced heating method. The synthesis procedure for both methods were simple and effective because the hybrid nanofibrous mats showed considerable affinity to MOF particles and could be used without additional modifications. The obtained MOF composites exhibited effective incorporation between MOF particles and the porous substrates. MIL-53(Al) composite was applied as fibrous sorbent and showed enhanced adsorption capacity and removal rate, as well as easier operation, compared with thepowdered sample. Moreover, MIL-53(Al) composite was easier to be regenerated compared with powder form.

  6. Hydrogen storage by carbon materials synthesized from oil seeds and fibrous plant materials

    Energy Technology Data Exchange (ETDEWEB)

    Sharon, Maheshwar; Bhardwaj, Sunil; Jaybhaye, Sandesh [Nanotechnology Research Center, Birla College, Kalyan 421304 (India); Soga, T.; Afre, Rakesh [Graduate School of Engineering, Nagoya Institute of Technology, Nagoya (Japan); Sathiyamoorthy, D.; Dasgupta, K. [Powder Metallurgy Division, BARC, Trombay 400 085 (India); Sharon, Madhuri [Monad Nanotech Pvt. Ltd., A702 Bhawani Tower, Powai, Mumbai 400 076 (India)

    2007-12-15

    Carbon materials of various morphologies have been synthesized by pyrolysis of various oil-seeds and plant's fibrous materials. These materials are characterized by SEM and Raman. Surface areas of these materials are determined by methylene blue method. These carbon porous materials are used for hydrogen storage. Carbon fibers with channel type structure are obtained from baggas and coconut fibers. It is reported that amongst the different plant based precursors studied, carbon from soyabean (1.09 wt%) and baggas (2.05 wt%) gave the better capacity to store hydrogen at 11kg/m{sup 2} pressure of hydrogen at room temperature. Efforts are made to correlate the hydrogen adsorption capacity with intensities and peak positions of G- and D-band obtained with carbon materials synthesized from plant based precursors. It is suggested that carbon materials whose G-band is around 1575cm{sup -1} and the intensity of D-band is less compared to G-band, may be useful material for hydrogen adsorption study. (author)

  7. Modeling the Residual Strength of a Fibrous Composite Using the Residual Daniels Function

    Science.gov (United States)

    Paramonov, Yu.; Cimanis, V.; Varickis, S.; Kleinhofs, M.

    2016-09-01

    The concept of a residual Daniels function (RDF) is introduced. Together with the concept of Daniels sequence, the RDF is used for estimating the residual (after some preliminary fatigue loading) static strength of a unidirectional fibrous composite (UFC) and its S-N curve on the bases of test data. Usually, the residual strength is analyzed on the basis of a known S-N curve. In our work, an inverse approach is used: the S-N curve is derived from an analysis of the residual strength. This approach gives a good qualitive description of the process of decreasing residual strength and explanes the existence of the fatigue limit. The estimates of parameters of the corresponding regression model can be interpreted as estimates of parameters of the local strength of components of the UFC. In order to approach the quantitative experimental estimates of the fatigue life, some ideas based on the mathematics of the semiMarkovian process are employed. Satisfactory results in processing experimental data on the fatigue life and residual strength of glass/epoxy laminates are obtained.

  8. Hierarchically structured polysulfone/titania fibrous membranes with enhanced air filtration performance.

    Science.gov (United States)

    Wan, Huigao; Wang, Na; Yang, Jianmao; Si, Yinsong; Chen, Kun; Ding, Bin; Sun, Gang; El-Newehy, Mohamed; Al-Deyab, Salem S; Yu, Jianyong

    2014-03-01

    Hierarchically structured, superhydrophobic filter medium exhibiting robust filtration performance to airborne particulate were prepared by a facile deposition of electrospun polysulfone/titania nanoparticles (PSU/TiO2 NPs) on a conventional nonwoven substrate. The air permeability, tensile strength and abrasion resistance of pristine PSU fibrous membranes could be finely controlled by regulating the solvent composition and number ratios of jets. By employing the TiO2 NPs incorporation, the pristine PSU fibers were endowed with promising superhydrophobicity with a water contact angle of up to 152°. The quantitative hierarchical roughness analysis using N2 adsorption method has confirmed the major contribution of TiO2 NPs on enhancing the porous structure and surface fractal features with irregular rough structure. Filtration performance studies have revealed that the filtration efficiency and pressure drop of resultant hybrid membranes could be manipulated by tuning the surface composition as well as the hierarchical structures. Furthermore, the as-prepared PSU/TiO2-5 membrane exhibited improved filtration efficiency (99.997%) and pressure drop (45.3 Pa) compared with pristine PSU membrane, which would make them a promising media for fine particle filtration, and a new insight was also provided into the design and development of high performance filter medium based on hierarchical structured fibers.

  9. Fibrous scaffolds loaded with protein prepared by blend or coaxial electrospinning.

    Science.gov (United States)

    Ji, Wei; Yang, Fang; van den Beucken, Jeroen J J P; Bian, Zhuan; Fan, Mingwen; Chen, Zhi; Jansen, John A

    2010-11-01

    The aim of the present study was to fabricate polycaprolactone-based nanofibrous scaffolds with incorporated protein via either the blend or coaxial electrospinning technique. Both techniques were compared with respect to processing set-up and scaffold characteristics as well as the release kinetics and biological activity of the loaded protein. Bovine serum albumin was used as a model protein to determine release profiles, while alkaline phosphatase was used to determine protein activity after the electrospinning process. Coaxial electrospinning resulted in a uniform fiber morphology with a core-shell structure, and a homogeneous protein distribution throughout the core of the fibers. In contrast, blend electrospinning formed bead-like fibers with a heterogeneous protein distribution in the fibers. The coaxial scaffold exhibited more sustained release profiles than the comparative blend scaffold, and the additive poly(ethylene glycol) (PEG) in the coaxial scaffold accelerated protein release. Both electrospinning processes decreased the biological activity of the incorporated protein, but coaxial electrospinning with PEG as an additive showed up to 75% preservation of the initial biological activity. Thus, coaxial electrospinning was demonstrated to be superior to blend electrospinning for the preparation of nanofibrous scaffolds with a uniform fibrous structure and protein distribution and sustained protein release kinetics as well as high preservation of the protein activity.

  10. Butyric acid fermentation in a fibrous bed bioreactor with immobilized Clostridium tyrobutyricum from cane molasses.

    Science.gov (United States)

    Jiang, Ling; Wang, Jufang; Liang, Shizhong; Wang, Xiaoning; Cen, Peilin; Xu, Zhinan

    2009-07-01

    Butyrate fermentation by immobilized Clostridium tyrobutyricum was successfully carried out in a fibrous bed bioreactor using cane molasses. Batch fermentations were conducted to investigate the influence of pH on the metabolism of the strain, and the results showed that the fermentation gave a highest butyrate production of 26.2 g l(-1) with yield of 0.47 g g(-1) and reactor productivity up to 4.13 g l(-1)h(-1) at pH 6.0. When repeated-batch fermentation was carried out, long-term operation with high butyrate yield, volumetric productivity was achieved. Several cane molasses pretreatment techniques were investigated, and it was found that sulfuric acid treatment gave better results regarding butyrate concentration (34.6+/-0.8 g l(-1)), yield (0.58+/-0.01 g g(-1)), and sugar utilization (90.8+/-0.9%). Also, fed-batch fermentation from cane molasses pretreated with sulfuric acid was performed to further increase the concentration of butyrate up to 55.2 g l(-1).

  11. Enhanced butyric acid tolerance and bioproduction by Clostridium tyrobutyricum immobilized in a fibrous bed bioreactor.

    Science.gov (United States)

    Jiang, Ling; Wang, Jufang; Liang, Shizhong; Cai, Jin; Xu, Zhinan; Cen, Peilin; Yang, Shangtian; Li, Shuang

    2011-01-01

    Repeated fed-batch fermentation of glucose by Clostridium tyrobutyricum immobilized in a fibrous bed bioreactor (FBB) was successfully employed to produce butyric acid at a high final concentration as well as to adapt a butyric-acid-tolerant strain. At the end of the eighth fed-batch fermentation, the butyric acid concentration reached 86.9 ± 2.17 g/L, which to our knowledge is the highest butyric acid concentration ever produced in the traditional fermentation process. To understand the mechanism and factors contributing to the improved butyric acid production and enhanced acid tolerance, adapted strains were harvested from the FBB and characterized for their physiological properties, including specific growth rate, acid-forming enzymes, intracellular pH, membrane-bound ATPase and cell morphology. Compared with the original culture used to seed the bioreactor, the adapted culture showed significantly reduced inhibition effects of butyric acid on specific growth rate, cellular activities of butyric-acid-forming enzyme phosphotransbutyrylase (PTB) and ATPase, together with elevated intracellular pH, and elongated rod morphology.

  12. Sorption of triclosan on electrospun fibrous membranes: Effects of pH and dissolved organic matter

    Directory of Open Access Journals (Sweden)

    Jiangjie Xu

    2015-11-01

    Full Text Available Three hydrophobic and polyporous electrospun fibrous membranes (EFMs were prepared by electrospinning methoxy polyethylene glycol-poly(lactide-co-glycolide (MPEG-PLGA, poly(d,l-lactide-co-glycolide (PLGA and poly(d,l-lactide (PDLLA. The effects of pH and dissolved organic matter (DOM on triclosan (TCS sorption by EFMs in aqueous solution were investigated. The results indicated that hydrogen bonding, hydrophobic and π–π bonding interactions led to fast adsorption, which governed the adsorption rates of TCS onto EFMs. The maximum sorption capacities of MPEG-PLGA, PLGA and PDLLA reached 130, 93 and 99 mg g−1, respectively, which were in positive correlation with their pore volumes and influenced by pore filling processes. The solution pH could significantly influence the TCS sorption by EFMs. In acid condition, protonated TCS facilitated their sorption onto EFMs. No obvious sorption was observed in alkaline condition due to repulsive forces between negatively charged EFMs and deprotonated TCS (pKa = 7.9. The presence of DOM inhibited TCS sorption onto EFMs due to competitive adsorption. The results could be due to the occupation of the adsorption sites and the blockage of the pore entrance by DOM.

  13. Thermodynamic analysis on preparation of fibrous NiO precursor powders with oxalate precipitation process

    Institute of Scientific and Technical Information of China (English)

    ZHAN Jing; ZHANG Chuan-fu; LI Tie-jing; WU Jian-hui

    2005-01-01

    According to the principles of simultaneous equilibrium and mass balance, a series of thermodynamic equilibrium equations of Ni( Ⅱ )-C2O2-4NH3-NH4+-H2O system at ambient temperature are deduced theoretically and the logarithm concentration versus pH value(lg[Ni2+]T-pH) diagrams at different solution compositions are drawn. The results show that when pH is above 8.0, nickel ions coordinate with ammonia, the precipitation proand the morphology of NiO powder precursor is fibrous; when pH is below 8.0, nickel ion directly reacts with C2O2-4 and the morphology of NiO powder precursor is of cubic-shape. Some experiments were made to confirm the relation between the total concentration of nickel ion and pH. It is shown that the thermodynamic mathematical model is correct and the calculated values are basically accurate.

  14. A Fibrous Localized Drug Delivery Platform with NIR-Triggered and Optically Monitored Drug Release.

    Science.gov (United States)

    Liu, Heng; Fu, Yike; Li, Yangyang; Ren, Zhaohui; Li, Xiang; Han, Gaorong; Mao, Chuanbin

    2016-09-06

    Implantable localized drug delivery systems (LDDSs) with intelligent functionalities have emerged as a powerful chemotherapeutic platform in curing cancer. Developing LDDSs with rationally controlled drug release and real-time monitoring functionalities holds promise for personalized therapeutic protocols but suffers daunting challenges. To overcome such challenges, a series of porous Yb(3+)/Er(3+) codoped CaTiO3 (CTO:Yb,Er) nanofibers, with specifically designed surface functionalization, were synthesized for doxorubicin (DOX) delivery. The content of DOX released could be optically monitored by increase in the intensity ratio of green to red emission (I550/I660) of upconversion photoluminescent nanofibers under 980 nm near-infrared (NIR) excitation owing to the fluorescence resonance energy transfer (FRET) effect between DOX molecules and the nanofibers. More importantly, the 808 nm NIR irradiation enabled markedly accelerated DOX release, confirming representative NIR-triggered drug release properties. In consequence, such CTO:Yb,Er nanofibers presented significantly enhanced in vitro anticancer efficacy under NIR irradiation. This study has thus inspired another promising fibrous LDDS platform with NIR-triggered and optics-monitored DOX releasing for personalized tumor chemotherapy.

  15. Experimental investigation of air pressure affecting filtration performance of fibrous filter sheet.

    Science.gov (United States)

    Xu, Bin; Yu, Xiao; Wu, Ya; Lin, Zhongping

    2017-03-01

    Understanding the effect of air pressure on their filtration performance is important for assessing the effectiveness of fibrous filters under different practical circumstances. The effectiveness of three classes of air filter sheets were investigated in laboratory-based measurements at a wide range of air pressures (60-130 KPa). The filtration efficiency was found most sensitive to the air pressure change at smaller particle sizes. As the air pressure increased from 60 to 130 KPa, significant decrease in filtration efficiency (up to 15%) and increase in pressure drop (up to 90 Pa) were observed. The filtration efficiency of the filter sheet with largest fiber diameter and smallest solid volume fraction was affected most, while the pressure drop of the filter sheet with smallest fiber diameter and largest solid volume fraction was affected most. The effect of air pressure on the filtration efficiency was slightly larger at greater filter face air velocity. However, the effect of air pressure on the pressure drop was negligible. The filtration efficiency and pressure drop were explicitly expressed as functions of the air pressure. Two coefficients were empirically derived and successfully accounted for the effects of air pressure on filtration efficiency and pressure drop.

  16. Numerical analysis of viscous flow through fibrous media: a model for glomerular basement membrane permeability.

    Science.gov (United States)

    Palassini, M; Remuzzi, A

    1998-01-01

    Viscous flow through fibrous media is characterized macroscopically by the Darcy permeability (KD). The relationship between KD and the microscopic structure of the medium has been the subject of experimental and theoretical investigations. Calculations of KD based on the solution of the hydrodynamic flow at fiber scale exist in literature only for two-dimensional arrays of parallel fibers. We considered a fiber matrix consisting of a three-dimensional periodic array of cylindrical fibers with uniform radius (r) and length connected in a tetrahedral structure. According to recent ultrastructural studies, this array of fibers can represent a model for the glomerular basement membrane (GBM). The Stokes flow through the periodic array was simulated using a Galerkin finite element method. The dimensionless ratio K* = KD/r2 was determined for values of the fractional solid volume (phi) in the range 0.005 equation only for phi > 0.4. Among the other theoretical analysis considered, only that of Spielman and Goren (Environ. Sci. Technol. 2: 279-287, 1968) gives satisfactory agreement in the whole range of phi considered. These results can be useful to model combined transport of water and macromolecules through the GBM for the estimation of the radius and length of extracellular protein fibrils.

  17. Biomimetic repeat protein derived from Xenopus tropicalis for fibrous scaffold fabrication.

    Science.gov (United States)

    Kwon, Yunkyeoung; Yang, Yun Jung; Jung, Dooyup; Hwang, Byeong Hee; Cha, Hyung Joon

    2015-12-01

    Collagen, silk, and elastin are the fibrous proteins consist of representative amino acid repeats. Because these proteins exhibited distinguishing mechanical properties, they have been utilized in diverse applications, such as fiber-based sensors, filtration membranes, supporting materials, and tissue engineering scaffolds. Despite their infinite prevalence and potential, most studies have only focused on a few repeat proteins. In this work, the hypothetical protein with a repeat motif derived from the frog Xenopus tropicalis was obtained and characterized for its potential as a novel protein-based material. The codon-optimized recombinant frog repeat protein, referred to as 'xetro', was produced at a high rate in a bacterial system, and an acid extraction-based purified xetro protein was successfully fabricated into microfibers and nanofibers using wet spinning and electrospinning, respectively. Specifically, the wet-spun xetro microfibers demonstrated about 2- and 1.5-fold higher tensile strength compared with synthetic polymer polylactic acid and cross-linked collagen, respectively. In addition, the wet-spun xetro microfibers showed about sevenfold greater stiffness than collagen. Therefore, the mass production potential and greater mechanical properties of the xetro fiber may result in these fibers becoming a new promising fiber-based material for biomedical engineering.

  18. Enhanced Vascularization in Hybrid PCL/Gelatin Fibrous Scaffolds with Sustained Release of VEGF

    Directory of Open Access Journals (Sweden)

    Kai Wang

    2015-01-01

    Full Text Available Creating a long-lasting and functional vasculature represents one of the most fundamental challenges in tissue engineering. VEGF has been widely accepted as a potent angiogenic factor involved in the early stages of blood vessel formation. In this study, fibrous scaffolds that consist of PCL and gelatin fibers were fabricated. The gelatin fibers were further functionalized by heparin immobilization, which provides binding sites for VEGF and thus enables the sustained release of VEGF. In vitro release test confirms the sustained releasing profile of VEGF, and stable release was observed over a time period of 25 days. In vitro cell assay indicates that VEGF release significantly promoted the proliferation of endothelial cells. More importantly, in vivo subcutaneous implantation reflects that vascularization has been effectively enhanced in the PCL/gelatin scaffolds compared with the PCL counterpart due to the sustained release of VEGF. Therefore, the heparinized PCL/gelatin scaffolds developed in this study may be a promising candidate for regeneration of complex tissues with sufficient vascularization.

  19. Bilateral additional slips of triceps brachii forming osseo-musculo-fibrous tunnels for ulnar nerves.

    Science.gov (United States)

    Swamy, Rs; Rao, Mkg; Somayaji, Sn; Raghu, J; Pamidi, N

    2013-07-01

    Rare additional slips of triceps brachii muscle was found bilaterally in a sixty two year old South Indian male cadaver during routine dissection of upper limb for undergraduate students at Melaka-Manipal Medical College, Manipal University, Manipal, India. On left side, the variant additional muscle slip took origin from the lower part of the medial intermuscular septum about 4 cm proximal to the medial humeral epicondyle. From its origin, the muscle fibres were passing over the ulnar nerve and were joining the triceps muscle to get inserted to the upper surface of olecranon process of ulna. On right side, the additional muscle slip was larger and bulkier and was arising from the lower part of the medial border of the humerus about 4 cm proximal to the medial epicondyle in addition to its attachment to the medial intermuscular septum. On both sides, the additional slips were supplied by twigs from the radial nerve. On both sides, the ulnar nerve was passing between variant additional slip and the lower part of the shaft of the humerus in an osseo-musculo-fibrous tunnel. Such variant additional muscle slips may affect the function of triceps muscle and can lead to snapping of medial head of triceps and ulnar nerve over medial epicondyle and also can dynamically compress the ulnar nerve during the contraction of triceps leading to ulnar neuropathy around the elbow.

  20. Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye Young; Seo, Jung Wook; Lee, Byung Hoon; Lee, Ji Young; Kim, Su Young; Cha, Soon Joo; Kim, Yong Hoon; Hwang, Yoon Joon; Kim, You Sung [Dept. of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang (Korea, Republic of)

    2013-03-15

    A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

  1. Electrospun PLGA/gelatin fibrous tubes for the application of biodegradable intestinal stent in rat model.

    Science.gov (United States)

    Son, So-Ra; Franco, Rose-Ann; Bae, Sang-Ho; Min, Young-Ki; Lee, Byong-Taek

    2013-08-01

    A biodegradable fibrous tube was fabricated by electrospinning method using a combination of Poly(lactic-co-glycolic acid) (PLGA) and gelatin dissolved in trifluoroethanol (TFE). Different ratios of the two polymers (PLGA/Gelatin: 1/9, 3/7, 5/5) were used for electrospinning to determine the optimum condition appropriate for intestinal stent application. Fiber morphology was visualized and analyzed using a scanning electron microscope (SEM). Characterizations of physical properties were done according to its tensile strength, surface hydrophilicity, swelling ability, and biodegradability. Biocompatibility of the scaffolds was investigated in vitro using IEC-18 (Rat intestinal epithelial cell). Cell proliferation was quantified using MTT assay and cell adhesion behavior was visualized by SEM and confocal laser scanning microscope. PLGA/Gelatin (5/5) was determined to have adequate material properties and sufficient in vitro biocompatibility. This was then implanted in a male Sprague-Dawley rat for 14 days to determine in vivo behavior of the sample. Histological examination on the intestinal tissue surrounding the graft showed normal morphology comparable to non-implanted intestine.

  2. Large solitary fibrous tumor of the oral cavity--report of a case.

    Science.gov (United States)

    de Oliveira, Denise Hélen Imaculada Pereira; Albuquerque, Assis Filipe Medeiros; de Araújo Barreto, Matheus Dantas; Nonaka, Cassiano Francisco Weege; da Silva, José Sandro Pereira; Germano, Adriano Rocha; Queiroz, Lélia Maria Guedes

    2014-12-01

    The solitary fibrous tumor (SFT) is a rare soft tissue tumor with a substantially benign clinical behavior. The SFT of the oral cavity is a very uncommon entity. It is also of complicated diagnosis because of its extensive morphologic diversity and because of its similarity to many mesenchymal tumors. A 44-year-old man was referred for management of an asymptomatic lesion in the left buccal mucosa, which had been identified 10 years earlier. Intra-oral examination revealed a well-demarcated, fibroelastic, rounded exophytic mass located in the left buccal mucosa. The mass was covered with a non-ulcerated mucosa of normal color and measured approximately 4.0 cm in diameter. Histopathological examination showed proliferation of spindle-shaped cells arranged in fascicles and in a patternless pattern, highly vascularized, with focal staghorn vessels. Immunohistochemical analysis revealed diffuse positivity for CD34 and focal positivity for Bcl-2. Awareness of the morphological diversity of SFT coupled to a judicious use of appropriate immunohistochemical probes should prove valuable to accurately segregate SFT from other spindle cell neoplasms.

  3. Mechanical properties of electrospun bilayer fibrous membranes as potential scaffolds for tissue engineering.

    Science.gov (United States)

    Pu, Juan; Komvopoulos, Kyriakos

    2014-06-01

    Bilayer fibrous membranes of poly(l-lactic acid) (PLLA) were fabricated by electrospinning, using a parallel-disk mandrel configuration that resulted in the sequential deposition of a layer with fibers aligned across the two parallel disks and a layer with randomly oriented fibers, both layers deposited in a single process step. Membrane structure and fiber alignment were characterized by scanning electron microscopy and two-dimensional fast Fourier transform. Because of the intricacies of the generated electric field, bilayer membranes exhibited higher porosity than single-layer membranes consisting of randomly oriented fibers fabricated with a solid-drum collector. However, despite their higher porosity, bilayer membranes demonstrated generally higher elastic modulus, yield strength and toughness than single-layer membranes with random fibers. Bilayer membrane deformation at relatively high strain rates comprised multiple abrupt microfracture events characterized by discontinuous fiber breakage. Bilayer membrane elongation yielded excessive necking of the layer with random fibers and remarkable fiber stretching (on the order of 400%) in the layer with fibers aligned in the stress direction. In addition, fibers in both layers exhibited multiple localized necking, attributed to the nonuniform distribution of crystalline phases in the fibrillar structure. The high membrane porosity, good mechanical properties, and good biocompatibility and biodegradability of PLLA (demonstrated in previous studies) make the present bilayer membranes good scaffold candidates for a wide range of tissue engineering applications.

  4. A model for the anisotropic response of fibrous soft tissues using six discrete fibre bundles

    KAUST Repository

    Flynn, Cormac

    2011-06-30

    The development of constitutive models of fibrous soft-tissues is a challenging problem. Many consider the tissue to be a collection of fibres with a continuous distribution function representing their orientations. A discrete fibre model is presented consisting of six weighted fibre-bundles. Each bundle is oriented such that it passes through opposing vertices of a regular icosahedron. A novel aspect is the use of simple analytical distribution functions to simulate undulated collagen fibres. This approach yields closed-form analytical expressions for the strain energy of the collagen fibre-bundle that avoids the sometimes costly numerical integration of some statistical distribution functions. The elastin fibres are characterized by a modified neo-Hookean type strain energy function which does not allow for fibre compression. The model accurately simulates biaxial stretching of rabbit-skin (error-of-fit 8.7), uniaxial stretching of pig-skin (error-of-fit 7.6), equibiaxial loading of aortic valve cusp (error-of-fit 0.8), and simple shear of rat septal myocardium (error-of-fit 8.9). It compares favourably with previous soft-tissue models and alternative methods of representing undulated collagen fibres. Predicted collagen fibre stiffnesses range from 8.0thinspaceMPa to 930MPa. Elastin fibre stiffnesses range from 2.0 kPa to 154.4 kPa. © 2011 John Wiley & Sons, Ltd.

  5. Coexisting Sclerosing Angiomatoid Nodular Transformation of the Spleen with Multiple Calcifying Fibrous Pseudotumors in a Patient

    Directory of Open Access Journals (Sweden)

    Jen-Chieh Lee

    2007-01-01

    Full Text Available Primary tumor or tumor-like lesions of the spleen are rare. Among them, vascular lesions are the most common. Vascular tumor of the spleen is different from the usual hemangioma of soft tissue because the vascular structure of the spleen is unique. Sclerosing angiomatoid nodular transformation (SANT is a recently described vascular lesion of the spleen. Grossly, it is a multinodular, well-circumscribed tumor containing a hypervascular core. Microscopically, it comprises three types of vessels, and each type recapitulates the immunohistochemical characteristics of the normal vascular elements of the splenic red pulp, i.e. capillaries, sinusoids, and small veins, respectively. Because of the rarity of this entity, its actual pathogenesis is still unknown. In this study, we report a case of SANT occurring in a 43-year-old woman, in whom there were also multiple calcifying fibrous pseudotumors (CFPTs in the abdominal cavity. Both SANT and CFPT are thought to be variants of inflammatory pseudotumor. Coexistence of these two rare entities in a patient has never been reported, and this fact suggests that there might be a common mechanism contributing to the formation of these two types of lesions. [J Formos Med Assoc 2007;106(3:234-239

  6. Fabrication of highly aligned fibrous scaffolds for tissue regeneration by centrifugal spinning technology.

    Science.gov (United States)

    Loordhuswamy, Amalorpava Mary; Krishnaswamy, Venkat Raghavan; Korrapati, Purna Sai; Thinakaran, Senthilram; Rengaswami, Giri Dev Venkateshwarapuram

    2014-09-01

    Centrifugal spinning (C-Spin) is an emerging technology which uses centrifugal force to produce ultrafine fibers. Being a voltage free technique it can overcome the limitations of electrospinning. Owing to the unique characteristic features such as high surface area to volume ratio, porosity, mechanical strength and fiber alignment, centrifugal spun (C-spun) fibrous mat has a wide range of scope in various biomedical applications. Higher degree of fiber alignment can be effortlessly achieved by the C-Spin process. In order to prove the versatility of C-Spin system with respect to fiber alignment, Polycaprolactone (PCL) and gelatin were spun taking them as model polymers. The morphological analysis revealed that highly aligned ultrafine fibers with smooth surface are achieved by C-Spinning. Hydrophilicity, porosity and mechanical property results confirm that the C-spun mat is more suitable for tissue engineering applications. In vitro and in vivo experiments proved that the scaffolds are biocompatible and can be efficiently used as a wound dressing material.

  7. McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Collins Michael T

    2012-05-01

    Full Text Available Abstract Fibrous dysplasia (FD is sometimes accompanied by extraskeletal manifestations that can include any combination of café-au-lait macules, hyperfunctioning endocrinopathies, such as gonadotropin-independent precocious puberty, hyperthyroidism, growth hormone excess, FGF23-mediated renal phosphate wasting, and/or Cushing syndrome, as well as other less common features. The combination of any of these findings, with or without FD, is known as McCune-Albright syndrome (MAS. The broad spectrum of involved tissues and the unpredictable combination of findings owe to the fact that molecular defect is due to dominant activating mutations in the widely expressed signaling protein, Gsα, and the fact these mutations arises sporadically, often times early in development, prior to gastrulation, and can distribute across many or few tissues. The complexity can be mastered by a systematic screening of potentially involved tissues and cognizance that the pattern of involved tissues is established, to some degree, in utero. Thorough testing allows the clinician to establish, often times at presentation, the full extent of the disease, and importantly as well what tissues are unaffected. Treatment and follow-up can then be focused on affected systems and a meaningful prognosis can be offered to the patient and family. The authors outline screening and treatment strategies that allow for effective management of the extraskeletal manifestations of FD.

  8. McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia.

    Science.gov (United States)

    Collins, Michael T; Singer, Frederick R; Eugster, Erica

    2012-05-24

    Fibrous dysplasia (FD) is sometimes accompanied by extraskeletal manifestations that can include any combination of café-au-lait macules, hyperfunctioning endocrinopathies, such as gonadotropin-independent precocious puberty, hyperthyroidism, growth hormone excess, FGF23-mediated renal phosphate wasting, and/or Cushing syndrome, as well as other less common features. The combination of any of these findings, with or without FD, is known as McCune-Albright syndrome (MAS). The broad spectrum of involved tissues and the unpredictable combination of findings owe to the fact that molecular defect is due to dominant activating mutations in the widely expressed signaling protein, Gsα, and the fact these mutations arises sporadically, often times early in development, prior to gastrulation, and can distribute across many or few tissues.The complexity can be mastered by a systematic screening of potentially involved tissues and cognizance that the pattern of involved tissues is established, to some degree, in utero. Thorough testing allows the clinician to establish, often times at presentation, the full extent of the disease, and importantly as well what tissues are unaffected. Treatment and follow-up can then be focused on affected systems and a meaningful prognosis can be offered to the patient and family. The authors outline screening and treatment strategies that allow for effective management of the extraskeletal manifestations of FD.

  9. Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Nilufer Ozdemir Kutbay

    2015-01-01

    Full Text Available Aim. Fibrous dysplasia is a rare bone disease caused by missense mutation leading to abnormal fibroblast and osteoblast proliferation and increased bone resorption. FD can present in monostotic or polyostotic forms. About 3% of FD could be in association with McCune-Albright syndrome (MAS. Because FD is a rare disease, there is limited data in the literature about characteristics of disease and response to treatment. Methods. We present our five cases of FD with general properties and their responses to medical treatment. Results. Two of our patients had polyostotic and three had monostotic FD. One of the polyostotic patients had MAS. One of our patients had surgery for femur fractures, facial asymmetry, and findings of compression. Four patients were given pamidronate; one was given zoledronic acid as bisphosphonate treatment. Bone pain was relieved in all patients with medical treatment. Conclusion. There was a decrease in bone turnover markers to some degree with medical treatment but no radiological improvement was observed.

  10. Simultaneous Application of Fibrous Piezoresistive Sensors for Compression and Traction Detection in Glass Laminate Composites

    Science.gov (United States)

    Nauman, Saad; Cristian, Irina; Koncar, Vladan

    2011-01-01

    This article describes further development of a novel Non Destructive Evaluation (NDE) approach described in one of our previous papers. Here these sensors have been used for the first time as a Piecewise Continuous System (PCS), which means that they are not only capable of following the deformation pattern but can also detect distinctive fracture events. In order to characterize the simultaneous compression and traction response of these sensors, multilayer glass laminate composite samples were prepared for 3-point bending tests. The laminate sample consisted of five layers of plain woven glass fabrics placed one over another. The sensors were placed at two strategic locations during the lay-up process so as to follow traction and compression separately. The reinforcements were then impregnated in epoxy resin and later subjected to 3-point bending tests. An appropriate data treatment and recording device has also been developed and used for simultaneous data acquisition from the two sensors. The results obtained, under standard testing conditions have shown that our textile fibrous sensors can not only be used for simultaneous detection of compression and traction in composite parts for on-line structural health monitoring but their sensitivity and carefully chosen location inside the composite ensures that each fracture event is indicated in real time by the output signal of the sensor. PMID:22163707

  11. Inflammatory fibrous hyperplasia treated with a modified vestibuloplasty: a case report.

    Science.gov (United States)

    Jaimes, Miguel; Muñante, Jose; Olate, Sergio; Rodriguez-Chessa, Jaime Giuseppe; de Albergaria-Barbosa, Jose Ricardo; Mazzonetto, Renato; Klüppel, Leandro Eduardo

    2008-03-01

    The purpose of this report is to present a case of surgical and prosthetic treatment of a woman with inflammatory fibrous hyperplasia (IFH) and her evaluation during a six month period. IFH is a benign pathology, prevalent in female patients, and principally associated with ill-fitting prosthetic devices in need of adjustment. It is common for patients to require surgical removal of the hyperplastic tissue and fabrication of a new prosthesis. A 55-year-old female with a history of smoking presented with a chief complaint of missing the scheduled adjustment of her maxillary complete denture and the presence of moveable tissue under the denture. Surgical excision of the hyperplastic tissue followed with fixation of the prosthesis for six months to guide the healing of the soft tissue and to reshape the contours of the maxillary supporting tissues. Surgical removal of hyperplasic soft tissue is a routine procedure, and the fixation of the prosthesis for the support of tissue during healing improves intraoral conditions for the fabrication of a new prosthesis in the future.

  12. Hierarchial coassembly of a cyanine dye in poly(vinyl alcohol) fibrous films by electrospinning.

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    Demir, Mustafa M; Horzum, Nesrin; Özen, Bengisu; Özçelik, Serdar

    2013-09-19

    We report molecular aggregate formation of TTBC (1,1',3,3'-tetraethyl-5,5',6,6'-tetrachlorobenzimidazolocarbocyanine) in submicrometer-sized PVA (poly(vinyl alcohol)) fibers by electrospinning. The formation of the molecular aggregate is examined by solution and instrumental parameters of electrospinning. The precursor solution of PVA/TTBC, in the range of 0.016-0.065 wt % is subjected to electrospinning under an electrical field ranging from 0.95 to 1.81 kV cm(-1). Both randomly deposited and uniaxially aligned fibers are achieved by using two parallel-positioned metal strips as counter electrode. Photoluminescence and polarized Fourier transform infrared spectroscopies are employed to determine spectral properties of the fibers. H-aggregates are formed within the electrospun fibers, regardless of their alignment, and H- and J-type aggregates coexist in the alternative spin-coated and the cast films. A strongly polarized photoluminescence emission is observed in the direction of uniaxially aligned fibers as a result of the orientation of the H-aggregates along the fiber axis. We demonstrate that electrospinning is a process capable of forming and orienting TTBC aggregates during the structural development of the polymer/dye nanofibers. These fibrous films may potentially find applications in optics and electronics.

  13. Synovial sarcoma with relevant immunocytochemistry and special emphasis on the monophasic fibrous variant

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    Kottu Radhika

    2010-01-01

    Full Text Available Background: Monophasic fibrous synovial sarcoma (SS is the most common variant of SS. Only a few cytological studies are available on this entity. Bcl-2 protein expression has been described as a characteristic marker of SS and is useful for its differentiation from other sarcomas. Cytokeratin and CD99 are also used in detecting SS. Aims: To evaluate synovial sarcoma and its variants cytomorphologically. Materials and Methods: During a period of 10 years 7 months, i.e. from January 1998 to July 2008, 12 cytologic specimens diagnosed as synovial sarcoma were reviewed. Ten cases were diagnosed as SS on aspiration alone but two cases required ancillary technique i.e., immunocytochemistry staining with bcl-2 and cytokeratin. The smears were stained with Papanicolaou and May-Grόnwald-Giemsa stains. Results: All cytologic specimens in our study had similar appearance. Most smears were highly cellular and were made up of densely packed tri-dimensional groups and singly scattered round to oval cells. Cellular monomorphism and vascular channels within the cell groups were the remarkable findings. Only one case showed cytologic evidence of epithelial differentiation. Bcl-2, cytokeratin, CD99 positivity was seen on immunohistochemistry staining. Results were categorized according to age, sex and morphologic variants. Conclusions: Although cytomorphologic features of synovial sarcomas are characteristic enough to permit its recognition, clinical correlation is necessary for accurate diagnosis. Monophasic variant is the most common entity observed in the present study.

  14. CT findings in malignant pleural mesothelioma related to nonoccupational exposure to asbestos and fibrous zeolite (erionite)

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    Erzen, C.; Eryilmaz, M.; Kalyoncu, F.; Bilir, N.; Sahin, A.; Baris, Y.I. (Hacettepe Univ., Ankara (Turkey))

    1991-03-01

    Endemic malignant pleural mesothelioma (MPM) in Turkey is related to two mineral fibers, tremolite asbestos and fibrous zeolite (erionite). Thirteen cases of MPM from the Cappadocian area, where the soil is rich in erionite, and 29 cases of MPM, from villages whose occupants have high asbestos exposure, were examined by CT. The CT findings of the two groups of MPM were compared with respect to the configuration of the pleural lesions, stage of disease, fissural involvement, pleural effusion, presence of calcified pleural plaques, and chronic fibrosing pleuritis. In erionite-related MPM the pleural lesions were flat and smooth in 69.1%; in asbestos-related MPM the lesions were nodular in 55.1%. Stage IV disease, calcified pleural plaques, and chronic fibrosing pleuritis were more common in the erionite-related MPM. The rest of the findings were similar in both groups. The early radiological diagnosis of erionite-related MPM may be even more difficult because of the similarity of the pleural lesions to chronic fibrosing pleuritis.

  15. Giant solitary fibrous tumor of the pleura causing respiratory insufficiency: report of 3 cases.

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    Abe, Masaru; Nomori, Hiroaki; Fukazawa, Motoji; Sugimura, Hiroshi; Narita, Makoto; Takeshi, Akihiko

    2014-01-01

    We present 3 cases of solitary fibrous tumors (SFTs) occupying entire hemithorax and resulting in respiratory insufficiency. All patients were treated by complete resection, resulting in immediate re-expansion of the lungs and recovery from respiratory insufficiency. Although, two patients remain alive without recurrence, one patient had pleural recurrences three times over a 20-year period, all of which were treated by surgical resection. All of the primary tumors exhibited areas of hypercellularity, hemorrhage, or necrosis. All of the recurrent tumors in the recurrent case displayed large areas of hypercellularity, similar to the part of primary tumor. Although, the MIB-1 index in primary tumors was less than 5%, the index of the recurrent tumors increased up to 11% with repeated recurrence. Giant SFTs usually display hypercellularity, hemorrhage, or necrosis. Tumors with hypercellularity could recur. MIB-1 index could display malignant characteristics of recurrent tumors. Long-term follow-up for more than 10 years after surgery is necessary, particularly for tumors with areas of hypercellularity.

  16. MR imaging of solitary fibrous tumors in the head and neck

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    Kim, Hyun Jeong [The Catholic University, Daejeon (Korea, Republic of); Lee, Ho Kyu; Shin, Ji Hoon; Lee, Jeong Hyun [Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Seo, Jeong Jin [Chonnam National University Medical School, Kwangju (Korea, Republic of); Kim, Hyung Jim [Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Jeong, Ae Kyung [University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2005-09-15

    Solitary fibrous tumor (SFT) is a very rare tumor. The purpose of this study is to determine the MR imaging features of SFT in the intracranial and extracranial head and neck regions. We retrospectively reviewed six MR images and two CT images of six histologically proven cases of SFT that occurred in four men and two women, and their ages ranged from 46 to 59 years. These imaging findings were correlated with the microscopic findings of their surgical specimens. Six SFTs arose in the meninges (the petrous ridge and the pituitary fossa), the parotid gland, the parapharyngeal space, the buccal space and the maxillary sinus. On the MR images, SFTs in the intracranial and extracranial head and neck regions were mostly isointense to the muscle on the T1-weighted images, they were hyperintense on the T2-weighted images and they all had intense enhancement. On the T1- and T2-weighted images, hypointense lines were observed within in five SFTs. On the CT images, the SFTs were hypodense to the muscle on the unenhanced images and they were heterogeneously enhanced on the contrast-enhanced images. An exceptional case of pituitary SFT was hypointense on the T2-weighted images and it was hyperdense on the unenhanced CT images, which correlated with the increased collagenous component and the cellular compactness. The imaging features of SFT are nonspecific; however, SFT should be included in the differential diagnosis of masses involving the intracranial and extracranial head and neck regions.

  17. A novel fibrous duct structure discovered in the brain meninges by using polarized light microscopy

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    Nam, Min-Ho; Jung, Sharon Jiyoon; Soh, Kwang-Sup; Lim, Jaekwan; Seo, Eunseok; Lim, Jun; Baek, Miok; Lee, Sang Joon

    2016-05-01

    We have previously reported the discovery of a novel fibrous structure (NFS) consisting of unidirectionally arranged collagen fibers in the spinal pia mater. Due to its unique structure, it was easily detected using polarized light microscopy. In the current study, we describe the discovery of a similar NFS in the brain meninges of rats by using polarized light microscopy. This NFS is located beneath the superior sagittal sinus. Initially, we systemically analyzed the polarization properties of the NFS. The change in the light intensity of the NFS, with respect to the polarization angle, was eight times greater than that of blood vessels, showing that the collagen fibers are oriented in a particular direction with almost perfect parallelism (0.99). The orientation angle of the polarization ellipse confirmed the orientation of the collagen fibers in the NFS. Histological studies further confirmed that the unidirectionally arranged collagen fibers were responsible for this distinct polarization property. Surprisingly, X-ray microtomography and 3D confocal imaging revealed that the NFS contains within it a duct structure, a putative primo vessel. In conclusion, we report a NFS in the brain meninges, detected by using polarized light microscopy, that provides space for a putative primo vessel, not a blood vessel.

  18. Prevention of disease caused by fluoro-edenite fibrous amphibole: the way forward

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    Caterina Bruno

    2015-06-01

    Full Text Available Few months after the publication of the monographic section of Annali dell'Istituto Superiore di Sanità second issue of 2014 "Health impact of fibres with fluoro-edenitic composition", the carcinogenicity of fluoro-edenite was assessed by the International Agency for Research on Cancer (IARC in the frame of Monograph 111. The IARC Working Group concluded that there is sufficient evidence in humans that exposure to fluoroedenite fibrous amphibole causes mesothelioma, and sufficient evidence of carcinogenicity in experimental animals. Fluoro-edenite was allocated to Group 1 (the agent is carcinogenic to humans. Now, in view of the recent IARC evaluation, preventive action in Biancavilla requires an upgrade. First of all, environmental monitoring has to be further implemented. All operations of house cleaning should be performed employing wet tools, in order to avoid dust-raising. It is very important that environmental and biological monitoring be related to epidemiological surveillance. The recently approved act of the Sicilian Government concerning a plan of health interventions in Biancavilla will favour cooperation between national, regional and local health institutions with the common goal of improving the quality and appropriateness of diagnostic and therapeutics procedures offered by the health services.

  19. Two-Scale Modeling Approach to Predict Permeability of Fibrous Media

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    Sudhakar Jaganathan

    2008-06-01

    Full Text Available We previously demonstrated how one can develop a 3-D geometry to model the fibrous microstructure of a nonwoven fiberweb and use it to simulate its permeability at fiber level [1-6]. Developing 3-D models of most nonwoven fabrics (bonded fiberwebs, however, is cumbersome, as in the case of hydroentangled fabrics, for instance. In such cases, microscopic techniques are often used to generate 3-D images of the media’s microstructures. Nevertheless, whether the microstructure is modeled or obtained from 3-D imaging, extensive computational resources are required to use them in fluid flow simulations [7]. To circumvent this problem, a two-scale modeling approach is proposed here that allows us to simulate the entire thickness of a commercial fabric/filter on a personal computer. In particular, the microscale permeability of a hydroentangled nonwoven is computed using 3-D reconstructed microstructures obtained from Digital Volumetric Imaging (DVI. The resulting microstructural permeability tensors are then used in a macroscale porous model to simulate the flow through the material’s thickness and the calculation of its overall permeability.

  20. The Sink Term to Different Kinds of Fibrous Mat During the Unsaturated Filling Process

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    Lee, Yongjing; Yan, Shilin; Lee, Dequan; Yan, Fei

    2016-06-01

    The fibrous pre-form of resin transfer molding is a dual-scale porous medium with two distinct scales of pores, i.e., pores in intra- and inter-tow, which produce an unsaturated infiltration phenomenon during filling. A sink term representing the delayed flow rate from the inter-tow gap into the intra-tow one is introduced to establish governing equations. This study mainly analyzes the sink term by tow saturation during the microscopic flow. First, fiber-tow permeability is calculated by FLOTRAN of ANSYS, Second, periodic unit cells are built according to different structures, and the concrete expression of the sink term is indirectly obtained through the numerical simulation and date fitting of tow saturation under different pressure and viscosity conditions. Results indicate that: the FLOTRAN module can be used to calculate the permeability of fiber tow in two directions; Moreover, the filling time and infiltration process for diverse unit cells with the same volume fraction are different; under the same injection condition, different unit cells have different parameters for the sink term.