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Sample records for frequency selective channels

  1. Distributive estimation of frequency selective channels for massive MIMO systems

    KAUST Repository

    Zaib, Alam

    2015-12-28

    We consider frequency selective channel estimation in the uplink of massive MIMO-OFDM systems, where our major concern is complexity. A low complexity distributed LMMSE algorithm is proposed that attains near optimal channel impulse response (CIR) estimates from noisy observations at receive antenna array. In proposed method, every antenna estimates the CIRs of its neighborhood followed by recursive sharing of estimates with immediate neighbors. At each step, every antenna calculates the weighted average of shared estimates which converges to near optimal LMMSE solution. The simulation results validate the near optimal performance of proposed algorithm in terms of mean square error (MSE). © 2015 EURASIP.

  2. On Channel Estimation for Analog Network Coding in a Frequency-Selective Fading Channel

    Directory of Open Access Journals (Sweden)

    Sjödin Tomas

    2011-01-01

    Full Text Available Recently, broadband analog network coding (ANC was introduced for high-speed transmission over the wireless (frequency-selective fading channel. However, ANC requires the knowledge of channel state information (CSI for self-information removal and coherent signal detection. In ANC, the users' pilot signals interfere during the first slot, which renders the relay unable to estimate CSIs of different users, and, consequently, four time-slot pilot-assisted channel estimation (CE is required to avoid interference. Naturally, this will reduce the capacity of ANC scheme. In this paper, we theoretically analyze the bit error rate (BER performance of bi-directional broadband ANC communication based on orthogonal frequency division multiplexing (OFDM radio access. We also theoretically analyze the performance of the channel estimator's mean square error (MSE. The analysis is based on the assumption of perfect timing and frequency synchronization. The achievable BER performance and the estimator's MSE for broadband ANC is evaluated by numerical and computer simulation. We discuss how, and by how much, the imperfect knowledge of CSI affects the BER performance of broadband ANC. It is shown that the CE scheme achieves a slightly higher BER in comparison with ideal CE case for a low and moderate mobile terminal speed in a frequency-selective fading channel.

  3. Channel and delay estimation for base-station–based cooperative communications in frequency-selective fading channels

    Directory of Open Access Journals (Sweden)

    Hongjun Xu

    2011-07-01

    Full Text Available A channel and delay estimation algorithm for both positive and negative delay, based on the distributed Alamouti scheme, has been recently discussed for base-station–based asynchronous cooperative systems in frequency-flat fading channels. This paper extends the algorithm, the maximum likelihood estimator, to work in frequency-selective fading channels. The minimum mean square error (MMSE performance of channel estimation for both packet schemes and normal schemes is discussed in this paper. The symbol error rate (SER performance of equalisation and detection for both time-reversal space-time block code (STBC and single-carrier STBC is also discussed in this paper. The MMSE simulation results demonstrated the superior performance of the packet scheme over the normal scheme with an improvement in performance of up to 6 dB when feedback was used in the frequency-selective channel at a MSE of 3 x 10–2. The SER simulation results showed that, although both the normal and packet schemes achieved similar diversity orders, the packet scheme demonstrated a 1 dB coding gain over the normal scheme at a SER of 10–5. Finally, the SER simulations showed that the frequency-selective fading system outperformed the frequency-flat fading system.

  4. Secured Communication over Frequency-Selective Fading Channels: A Practical Vandermonde Precoding

    Directory of Open Access Journals (Sweden)

    Mari Kobayashi

    2009-01-01

    Full Text Available We study the frequency-selective broadcast channel with confidential messages (BCC where the transmitter sends a confidential message to receiver 1 and a common message to receivers 1 and 2. In the case of a block transmission of N symbols followed by a guard interval of L symbols, the frequency-selective channel can be modeled as a N×(N+L Toeplitz matrix. For this special type of multiple-input multiple-output channels, we propose a practical Vandermonde precoding that projects the confidential messages in the null space of the channel seen by receiver 2 while superposing the common message. For this scheme, we provide the achievable rate region and characterize the optimal covariance for some special cases of interest. Interestingly, the proposed scheme can be applied to other multiuser scenarios such as the K+1-user frequency-selective BCC with K confidential messages and the two-user frequency-selective BCC with two confidential messages. For each scenario, we provide the secrecy degree of freedom (s.d.o.f. region of the corresponding channel and prove the optimality of the Vandermonde precoding. One of the appealing features of the proposed scheme is that it does not require any specific secrecy encoding technique but can be applied on top of any existing powerful encoding schemes.

  5. Performance of transmit-reference radio system in frequency-selective fading channels

    NARCIS (Netherlands)

    Wang, Jing; Haartsen, J.C.

    2005-01-01

    Noise-based Transmit-Reference (TR) radio system is a simple and practical candidate for ultra-wideband (UWB) communication applications. This paper evaluates the performance of the Transmit-Reference radio system in a frequency-selective fading channel by theoretical analysis and computer

  6. Time-frequency doubly selective channel estimation based on compressed sensing

    Directory of Open Access Journals (Sweden)

    Tu Yuliang

    2017-02-01

    Full Text Available In this paper,considering time-frequency doubly selective channel,we utilize the channel's time correlation that the channel coefficientscorresponding tothe neighboring instants have a strong correlation.And we present a linear approximation method,which effectively reduces the number of unknown parameters.Considering the sparseness of the wireless channel in the delay domain,this paper reconstructs unknown channel parameters of the proposed model based on compressed sensing (CS theory.In the simulations,we observe the system performance of the linear approximation model and the non-linear approximation model,respectively,and present the normalized mean squared error (NMSE curves based on the least square (LS,orthogonal matching pursuit (OMP and sparse Bayesian learning (SBL algorithms.Simulation results show that the linear approximation method can effectively model the time-frequency doubly-selective channels.For the proposed linear approximation model,SBL algorithm can accurately recover the channel response,and overcome the Doppler effecteffectively.

  7. Low-Complexity Iterative Receiver for Space-Time Coded Signals over Frequency Selective Channels

    Directory of Open Access Journals (Sweden)

    Mohamed Siala

    2002-05-01

    Full Text Available We propose a low-complexity turbo-detector scheme for frequency selective multiple-input multiple-output channels. The detection part of the receiver is based on a List-type MAP equalizer which is a state-reduction algorithm of the MAP algorithm using per-survivor technique. This alternative achieves a good tradeoff between performance and complexity provided a small amount of the channel is neglected. In order to induce the good performance of this equalizer, we propose to use a whitened matched filter (WMF which leads to a white-noise “minimum phase” channel model. Simulation results show that the use of the WMF yields significant improvement, particularly over severe channels. Thanks to the iterative turbo processing (detection and decoding are iterated several times, the performance loss due to the use of the suboptimum List-type equalizer is recovered.

  8. Appropriate Algorithms for Estimating Frequency-Selective Rician Fading MIMO Channels and Channel Rice Factor: Substantial Benefits of Rician Model and Estimator Tradeoffs

    Directory of Open Access Journals (Sweden)

    Shirvani Moghaddam Shahriar

    2010-01-01

    Full Text Available The training-based channel estimation (TBCE scheme in multiple-input multiple-output (MIMO frequency-selective Rician fading channels is investigated. We propose the new technique of shifted scaled least squares (SSLS and the minimum mean square error (MMSE estimator that are suitable to estimate the above-mentioned channel model. Analytical results show that the proposed estimators achieve much better minimum possible Bayesian Cramér-Rao lower bounds (CRLBs in the frequency-selective Rician MIMO channels compared with those of Rayleigh one. It is seen that the SSLS channel estimator requires less knowledge about the channel and/or has better performance than the conventional least squares (LS and MMSE estimators. Simulation results confirm the superiority of the proposed channel estimators. Finally, to estimate the channel Rice factor, an algorithm is proposed, and its efficiency is verified using the result in the SSLS and MMSE channel estimators.

  9. Spreading Code Assignment Strategies for MIMO-CDMA Systems Operating in Frequency-Selective Channels

    Directory of Open Access Journals (Sweden)

    Dahmane AdelOmar

    2009-01-01

    Full Text Available Abstract Code Division Multiple Access (CDMA and multiple input multiple output- (MIMO- CDMA systems suffer from multiple access interference (MAI which limits the spectral efficiency of these systems. By making these systems more power efficient, we can increase the overall spectral efficiency. This can be achieved through the use of improved modulation and coding techniques. Conventional MIMO-CDMA systems use fixed spreading code assignments. By strategically selecting the spreading codes as a function of the data to be transmitted, we can achieve coding gain and introduce additional degrees of freedom in the decision variables at the output of the matched filters. In this paper, we examine the bit error rate performance of parity bit-selected spreading and permutation spreading under different wireless channel conditions. A suboptimal detection technique based on maximum likelihood detection is proposed for these systems operating in frequency selective channels. Simulation results demonstrate that these code assignment techniques provide an improvement in performance in terms of bit error rate (BER while providing increased spectral efficiency compared to the conventional system. Moreover, the proposed strategies are more robust to channel estimation errors as well as spatial correlation.

  10. Equivalence of Linear MMSE Detection in DS-CDMA and MC-CDMA Systems over Time and Frequency Selective Channels

    Directory of Open Access Journals (Sweden)

    Tamer A. Kadous

    2003-01-01

    Full Text Available The goal of this paper is to compare the performance of the linear minimum mean square error (MMSE detector for a class of code division multiple access (CDMA systems in time and frequency selective channels. Specifically, we consider direct sequence (DS-CDMA, multicarrier (MC-CDMA, and the MC-DS-CDMA systems. Two key tools are used in our development. First, a general time-frequency framework that includes the different CDMA systems as special cases. Second, the duality between time and frequency domains that is used to derive equivalences between the different CDMA systems operating over purely frequency selective and purely time selective channels. We then combine the insights obtained from these special cases to assess the performance of CDMA systems over time and frequency selective channels. We provide sufficient conditions for the codes employed by the CDMA systems for the equivalences to hold. Numerical results are presented to illustrate the results.

  11. Blind CP-OFDM and ZP-OFDM Parameter Estimation in Frequency Selective Channels

    Directory of Open Access Journals (Sweden)

    Vincent Le Nir

    2009-01-01

    Full Text Available A cognitive radio system needs accurate knowledge of the radio spectrum it operates in. Blind modulation recognition techniques have been proposed to discriminate between single-carrier and multicarrier modulations and to estimate their parameters. Some powerful techniques use autocorrelation- and cyclic autocorrelation-based features of the transmitted signal applying to OFDM signals using a Cyclic Prefix time guard interval (CP-OFDM. In this paper, we propose a blind parameter estimation technique based on a power autocorrelation feature applying to OFDM signals using a Zero Padding time guard interval (ZP-OFDM which in particular excludes the use of the autocorrelation- and cyclic autocorrelation-based techniques. The proposed technique leads to an efficient estimation of the symbol duration and zero padding duration in frequency selective channels, and is insensitive to receiver phase and frequency offsets. Simulation results are given for WiMAX and WiMedia signals using realistic Stanford University Interim (SUI and Ultra-Wideband (UWB IEEE 802.15.4a channel models, respectively.

  12. A novel reduced-complexity group detection structure in MIMO frequency selective fading channels

    KAUST Repository

    Qaraqe, Khalid A.

    2010-09-01

    In this paper a novel reduced complexity detection method named modified symbol flipping method is introduced and its advantages on reducing the burden of the calculations at the receiver compared to the optimum maximum likelihood detection method on multiple input- multiple output frequency selective fading channels are explained. The initial concept of the symbol flipping method is derived from a preliminary detection scheme named bit flipping which was introduced in [1]. The detection structure employed in this paper is ing, detection, and cancellation. On the detection stage, the proposed method is employed and the results are compared to the group maximum likelihood detection scheme proposed in [2]. Simulation results show that a 6 dB performance gain can be achieved at the expense of a slight increase in complexity in comparison with the conventional symbol flipping scheme. © 2010 Crown.

  13. Performance Analysis of OFDM in Frequency Selective, Slowly Fading Nakagami Channels

    National Research Council Canada - National Science Library

    Count, Patrick

    2001-01-01

    In an effort to offer faster, more reliable wireless communications services to the public, many wireless standardization committees have, in recent years, adopted Orthogonal Frequency Division Multiplexing (OFDM...

  14. Space-Time Joint Interference Cancellation Using Fuzzy-Inference-Based Adaptive Filtering Techniques in Frequency-Selective Multipath Channels

    Directory of Open Access Journals (Sweden)

    Chen Yu-Fan

    2006-01-01

    Full Text Available An adaptive minimum mean-square error (MMSE array receiver based on the fuzzy-logic recursive least-squares (RLS algorithm is developed for asynchronous DS-CDMA interference suppression in the presence of frequency-selective multipath fading. This receiver employs a fuzzy-logic control mechanism to perform the nonlinear mapping of the squared error and squared error variation, denoted by ( , , into a forgetting factor . For the real-time applicability, a computationally efficient version of the proposed receiver is derived based on the least-mean-square (LMS algorithm using the fuzzy-inference-controlled step-size . This receiver is capable of providing both fast convergence/tracking capability as well as small steady-state misadjustment as compared with conventional LMS- and RLS-based MMSE DS-CDMA receivers. Simulations show that the fuzzy-logic LMS and RLS algorithms outperform, respectively, other variable step-size LMS (VSS-LMS and variable forgetting factor RLS (VFF-RLS algorithms at least 3 dB and 1.5 dB in bit-error-rate (BER for multipath fading channels.

  15. Frequency Selective Reflector Antenna

    Data.gov (United States)

    National Aeronautics and Space Administration — Frequency Selective Surfaces (FSS) are an electromagnetic structure where a relatively thin, periodic, conductive material is designed as a spatial filter of...

  16. A Joint Frequency-Domain Equalization (Fde and Antenna Diversity Combining Method for the Multipath Fading in the Frequency-Selective Channel

    Directory of Open Access Journals (Sweden)

    Wang Jinpeng

    2016-01-01

    Full Text Available In this study, a theoretical foundation is built to evaluate the downlink performance of an MC-CDMA cellular system with site diversity operation with and receive antenna diversity combining. An expression for the theoretical conditional bit error rate (BER for the given set of channel gains is derived based on Gaussian approximation of the interference components in the composite receive signal. The local average BER is then obtained by averaging the conditional BER over the given set of channel gains using Monte-Carlo numerical method. The outage probability is measured from the numerically obtained cumulative distribution of the local average BER to determine the downlink capacity. Results from theoretical computation are compared to the results from computer simulation and discussed.

  17. New Concept of PLC Modems: Multi-Carrier System for Frequency Selective Slow-Fading Channels Based on Layered SCCC Turbocodes

    Directory of Open Access Journals (Sweden)

    J. Zavrtalek

    2015-09-01

    Full Text Available The article introduces a novel concept of a PLC modem as a complement to the existing G3 and PRIME standards for communications using medium- or high-voltage overhead or cable lines. The proposed concept is based on the fact that the levels of impulse noise and frequency selectivity are lower on high-voltage lines than on low-voltage ones. Also, the demands for “cost-effective” circuitry design are not so crucial as in the case of modems for low-voltage level. In contract to these positive conditions, however, there is the need to overcome much longer distances and to take into account low SNR on the receiving side. With respect to the listed reasons, our concept makes use of MCM, instead of OFDM. The assumption of low SNR is compensated through the use of an efficient channel coding based on a serially concatenated turbo code. In addition, MCM offers lower latency and PAPR compared to OFDM. Therefore, when using MCM, it is possible to excite the line with higher power. The proposed concept has been verified during experimental transmission of testing data over a real, 5 km long, 22kV overhead line.

  18. Frequency selectivity at very low centre frequencies

    DEFF Research Database (Denmark)

    Orellana, Carlos Andrés Jurado; Pedersen, Christian Sejer; Marquardt, Torsten

    2010-01-01

    measurements based on OAE suppression techniques and notched-noise masking data psychophysically measured for centre frequencies in the range 50-125 Hz, this study examines how individual differences in frequency selectivity, as well as in masking, may occur at very low CFs due to individual differences...

  19. Block Transmissions over Doubly Selective Channels: Iterative Channel Estimation and Turbo Equalization

    Directory of Open Access Journals (Sweden)

    Rugini Luca

    2010-01-01

    Full Text Available Modern wireless communication systems require high transmission rates, giving rise to frequency selectivity due to multipath propagation. In addition, high-mobility terminals and scatterers induce Doppler shifts that introduce time selectivity. Therefore, advanced techniques are needed to accurately model the time- and frequency-selective (i.e., doubly selective channels and to counteract the related performance degradation. In this paper, we develop new receivers for orthogonal frequency-division multiplexing (OFDM systems and single-carrier (SC systems in doubly selective channels by embedding the channel estimation task within low-complexity block turbo equalizers. Linear minimum mean-squared error (MMSE pilot-assisted channel estimators are presented, and the soft data estimates from the turbo equalizers are used to improve the quality of the channel estimates.

  20. Theory of Alike Selectivity in Biological Channels

    Science.gov (United States)

    Luchinsky, Dmitry G.; Gibby, Will A. T.; Kaufman, Igor Kh.; Eisenberg, Robert S.; McClintock, Peter V. E.

    2016-01-01

    We introduce a statistical mechanical model of the selectivity filter that accounts for the interaction between ions within the channel and derive Eisenman equation of the filter selectivity directly from the condition of barrier-less conduction.

  1. Multiple spatial frequency channels in human visual perceptual memory.

    Science.gov (United States)

    Nemes, V A; Whitaker, D; Heron, J; McKeefry, D J

    2011-12-08

    Current models of short-term visual perceptual memory invoke mechanisms that are closely allied to low-level perceptual discrimination mechanisms. The purpose of this study was to investigate the extent to which human visual perceptual memory for spatial frequency is based upon multiple, spatially tuned channels similar to those found in the earliest stages of visual processing. To this end we measured how performance on a delayed spatial frequency discrimination paradigm was affected by the introduction of interfering or 'memory masking' stimuli of variable spatial frequency during the delay period. Masking stimuli were shown to induce shifts in the points of subjective equality (PSE) when their spatial frequencies were within a bandwidth of 1.2 octaves of the reference spatial frequency. When mask spatial frequencies differed by more than this value, there was no change in the PSE from baseline levels. This selective pattern of masking was observed for different spatial frequencies and demonstrates the existence of multiple, spatially tuned mechanisms in visual perceptual memory. Memory masking effects were also found to occur for horizontal separations of up to 6 deg between the masking and test stimuli and lacked any orientation selectivity. These findings add further support to the view that low-level sensory processing mechanisms form the basis for the retention of spatial frequency information in perceptual memory. However, the broad range of transfer of memory masking effects across spatial location and other dimensions indicates more long range, long duration interactions between spatial frequency channels that are likely to rely contributions from neural processes located in higher visual areas. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Frequency domain based LS channel estimation in OFDM based Power line communications

    OpenAIRE

    Bogdanović, Mario

    2015-01-01

    This paper is focused on low voltage power line communication (PLC) realization with an emphasis on channel estimation techniques. The Orthogonal Frequency Division Multiplexing (OFDM) scheme is preferred technology in PLC systems because of its effective combat with frequency selective fading properties of PLC channel. As the channel estimation is one of the crucial problems in OFDM based PLC system because of a problematic area of PLC signal attenuation and interference, the improved LS est...

  3. Channel selection for automatic seizure detection

    DEFF Research Database (Denmark)

    Duun-Henriksen, Jonas; Kjaer, Troels Wesenberg; Madsen, Rasmus Elsborg

    2012-01-01

    Objective: To investigate the performance of epileptic seizure detection using only a few of the recorded EEG channels and the ability of software to select these channels compared with a neurophysiologist. Methods: Fifty-nine seizures and 1419 h of interictal EEG are used for training and testing...

  4. On Data and Parameter Estimation Using the Variational Bayesian EM-algorithm for Block-fading Frequency-selective MIMO Channels

    DEFF Research Database (Denmark)

    Christensen, Lars P.B.; Larsen, Jan

    2006-01-01

    A general Variational Bayesian framework for iterative data and parameter estimation for coherent detection is introduced as a generalization of the EM-algorithm. Explicit solutions are given for MIMO channel estimation with Gaussian prior and noise covariance estimation with inverse-Wishart prior....... Simulation of a GSM-like system provides empirical proof that the VBEM-algorithm is able to provide better performance than the EM-algorithm. However, if the posterior distribution is highly peaked, the VBEM-algorithm approaches the EM-algorithm and the gain disappears. The potential gain is therefore...

  5. Single channel speech enhancement in the modulation domain: New insights in the modulation channel selection framework

    DEFF Research Database (Denmark)

    Boldt, Jesper B.; Bertelsen, Andreas Thelander; Gran, Fredrik

    2015-01-01

    Recently, the ideal binary mask has been introduced in the modulation domain by extending the ideal channel selection method to modulation channel selection [1]. This new method shows substantial improvement in speech intelligibility but less than its predecessor despite the higher complexity. Here......, we extend the previous finding from [1] and provide a more direct comparison of binary masking in the modulation domain with binary masking in the time-frequency domain. Subjective and objective evaluations are performed and provide additional insight into modulation domain processing....

  6. Estimation and Direct Equalization of Doubly Selective Channels

    NARCIS (Netherlands)

    Barhumi, I.; Leus, G.; Moonen, M.

    2006-01-01

    We propose channel estimation and direct equalization techniques for transmission over doubly selective channels. The doubly selective channel is approximated using the basis expansion model (BEM). Linear and decision feedback equalizers implemented by time-varying finite impulse response (FIR)

  7. Behavioral estimates of human frequency selectivity at low frequencies

    DEFF Research Database (Denmark)

    Orellana, Carlos Andrés Jurado

    on physical sound measurements. In this PhD thesis a detailed description of frequency selectivity at low frequencies is given. Different experiments have been performed to determine the properties of human auditory filters. Besides, loudness perception of low-frequency sinusoidal signals has been evaluated...

  8. Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels.

    Directory of Open Access Journals (Sweden)

    Radhakrishnan Gnanasambandam

    Full Text Available Members of the eukaryotic PIEZO family (the human orthologs are noted hPIEZO1 and hPIEZO2 form cation-selective mechanically-gated channels. We characterized the selectivity of human PIEZO1 (hPIEZO1 for alkali ions: K+, Na+, Cs+ and Li+; organic cations: TMA and TEA, and divalents: Ba2+, Ca2+, Mg2+ and Mn2+. All monovalent ions permeated the channel. At a membrane potential of -100 mV, Cs+, Na+ and K+ had chord conductances in the range of 35-55 pS with the exception of Li+, which had a significantly lower conductance of ~ 23 pS. The divalents decreased the single-channel permeability of K+, presumably because the divalents permeated slowly and occupied the open channel for a significant fraction of the time. In cell-attached mode, 90 mM extracellular divalents had a conductance for inward currents carried by the divalents of: 25 pS for Ba2+ and 15 pS for Ca2+ at -80 mV and 10 pS for Mg2+ at -50 mV. The organic cations, TMA and TEA, permeated slowly and attenuated K+ currents much like the divalents. As expected, the channel K+ conductance increased with K+ concentration saturating at ~ 45 pS and the KD of K+ for the channel was 32 mM. Pure divalent ion currents were of lower amplitude than those with alkali ions and the channel opening rate was lower in the presence of divalents than in the presence of monovalents. Exposing cells to the actin disrupting reagent cytochalasin D increased the frequency of openings in cell-attached patches probably by reducing mechanoprotection.

  9. NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels.

    Directory of Open Access Journals (Sweden)

    Adriano Senatore

    Full Text Available NALCN is a member of the family of ion channels with four homologous, repeat domains that include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene from simple, extant multicellular organisms without nervous systems such as sponges and placozoans and mostly remains a single gene compared to the calcium and sodium channels which diversified into twenty genes in humans. The single NALCN gene has alternatively-spliced exons at exons 15 or exon 31 that splices in novel selectivity filter residues that resemble calcium channels (EEEE or sodium channels (EKEE or EEKE. NALCN channels with alternative calcium, (EEEE and sodium, (EKEE or EEKE -selective pores are conserved in simple bilaterally symmetrical animals like flatworms to non-chordate deuterostomes. The single NALCN gene is limited as a sodium channel with a lysine (K-containing pore in vertebrates, but originally NALCN was a calcium-like channel, and evolved to operate as both a calcium channel and sodium channel for different roles in many invertebrates. Expression patterns of NALCN-EKEE in pond snail, Lymnaea stagnalis suggest roles for NALCN in secretion, with an abundant expression in brain, and an up-regulation in secretory organs of sexually-mature adults such as albumen gland and prostate. NALCN-EEEE is equally abundant as NALCN-EKEE in snails, but is greater expressed in heart and other muscle tissue, and 50% less expressed in the brain than NALCN-EKEE. Transfected snail NALCN-EEEE and NALCN-EKEE channel isoforms express in HEK-293T cells. We were not able to distinguish potential NALCN currents from background, non-selective leak conductances in HEK293T cells. Native leak currents without expressing NALCN genes in HEK-293T cells are NMDG(+ impermeant and blockable with 10 µM Gd(3+ ions and are indistinguishable from the hallmark currents ascribed to mammalian NALCN currents expressed in vitro by Lu et al. in Cell. 2007 Apr 20;129(2:371-83.

  10. Frequency Dependence of Measured Massive MIMO Channel Properties

    DEFF Research Database (Denmark)

    Oliveras Martínez, Àlex; Carvalho, Elisabeth De; Nielsen, Jesper Ødum

    2016-01-01

    A multi-user massive MIMO measurement campaign is conducted to study the channel propagation characteristics (e.g. user correlation, sum of eigenvalues and condition number), focusing on the stability over frequencies and the impact of the array aperture. We use 3 arrays with 64 antennas (6m linear...

  11. Standard compliant channel selection scheme for TV white space networks

    CSIR Research Space (South Africa)

    Masonta, MT

    2014-08-01

    Full Text Available an open issue. In this paper, an Analytic Hierarchy Process (AHP) based scheme is proposed for optimal channel decision. The best channel is selected from a pool of available channels provided by the GSDB. Each channel is ranked based on the current class...

  12. Modeling of Doppler frequency shift in multipath radio channels

    Directory of Open Access Journals (Sweden)

    Penzin M.S.

    2016-06-01

    Full Text Available We discuss the modeling of propagation of a quasi-monochromatic radio signal, represented by a coherent pulse sequence, in a non-stationary multipath radio channel. In such a channel, signal propagation results in the observed frequency shift for each ray (Doppler effect. The modeling is based on the assumption that during propagation of a single pulse a channel can be considered stationary. A phase variation in the channel transfer function is shown to cause the observed frequency shift in the received signal. Thus, instead of measuring the Doppler frequency shift, we can measure the rate of variation in the mean phase of one pulse relative to another. The modeling is carried out within the framework of the method of normal waves. The method enables us to model the dynamics of the electromagnetic field at a given point with the required accuracy. The modeling reveals that a local change in ionospheric conditions more severely affects the rays whose reflection region is in the area where the changes occur.

  13. P-Loop Residues Critical for Selectivity in K+ Channels Fail to Confer Selectivity to Rabbit HCN4 Channels

    OpenAIRE

    D'Avanzo, Nazzareno; Pekhletski, Roman; Backx, Peter H.

    2009-01-01

    HCN channels are thought to be structurally similar to Kv channels, but show much lower selectivity for K+. The approximately 3.3 A selectivity filter of K+ channels is formed by the pore-lining sequence XT(V/I)GYG, with X usually T, and is held stable by key residues in the P-loop. Differences in the P-loop sequence of HCN channels (eg. the pore-lining sequence L478C479IGYG) suggest these residues could account for differences in selectivity between these channel families. Despite being expr...

  14. Optimal complex exponentials BEM and channel estimation in doubly selective channel

    International Nuclear Information System (INIS)

    Song, Lijun; Lei, Xia; Yu, Feng; Jin, Maozhu

    2016-01-01

    Over doubly selective channel, the optimal complex exponentials BEM (CE-BEM) is required to characterize the transmission in transform domain in order to reducing the huge number of the estimated parameters during directly estimating the impulse response in time domain. This paper proposed an improved CE-BEM to alleviating the high frequency sampling error caused by conventional CE-BEM. On the one hand, exploiting the improved CE-BEM, we achieve the sampling point is in the Doppler spread spectrum and the maximum sampling frequency is equal to the maximum Doppler shift. On the other hand we optimize the function and dimension of basis in CE-BEM respectively ,and obtain the closed solution of the EM based channel estimation differential operator by exploiting the above optimal BEM. Finally, the numerical results and theoretic analysis show that the dimension of basis is mainly depend on the maximum Doppler shift and signal-to-noise ratio (SNR), and if fixing the number of the pilot symbol, the dimension of basis is higher, the modeling error is smaller, while the accuracy of the parameter estimation is reduced, which implies that we need to achieve a tradeoff between the modeling error and the accuracy of the parameter estimation and the basis function influences the accuracy of describing the Doppler spread spectrum after identifying the dimension of the basis.

  15. Tuning the ion selectivity of two-pore channels

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Jiangtao; Zeng, Weizhong; Jiang, Youxing (UTSMC)

    2017-01-17

    Organellar two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expressed in plants and animals. Interestingly, plant and animal TPCs share high sequence similarity in the filter region, yet exhibit drastically different ion selectivity. Plant TPC1 functions as a nonselective cation channel on the vacuole membrane, whereas mammalian TPC channels have been shown to be endo/lysosomal Na+-selective or Ca2+-release channels. In this study, we performed systematic characterization of the ion selectivity of TPC1 from Arabidopsis thaliana (AtTPC1) and compared its selectivity with the selectivity of human TPC2 (HsTPC2). We demonstrate that AtTPC1 is selective for Ca2+ over Na+, but nonselective among monovalent cations (Li+, Na+, and K+). Our results also confirm that HsTPC2 is a Na+-selective channel activated by phosphatidylinositol 3,5-bisphosphate. Guided by our recent structure of AtTPC1, we converted AtTPC1 to a Na+-selective channel by mimicking the selectivity filter of HsTPC2 and identified key residues in the TPC filters that differentiate the selectivity between AtTPC1 and HsTPC2. Furthermore, the structure of the Na+-selective AtTPC1 mutant elucidates the structural basis for Na+ selectivity in mammalian TPCs.

  16. Quantum Interference and Selectivity through Biological Ion Channels.

    Science.gov (United States)

    Salari, Vahid; Naeij, Hamidreza; Shafiee, Afshin

    2017-01-30

    The mechanism of selectivity in ion channels is still an open question in biology for more than half a century. Here, we suggest that quantum interference can be a solution to explain the selectivity mechanism in ion channels since interference happens between similar ions through the same size of ion channels. In this paper, we simulate two neighboring ion channels on a cell membrane with the famous double-slit experiment in physics to investigate whether there is any possibility of matter-wave interference of ions via movement through ion channels. Our obtained decoherence timescales indicate that the quantum states of ions can only survive for short times, i.e. ≈100 picoseconds in each channel and ≈17-53 picoseconds outside the channels, giving the result that the quantum interference of ions seems unlikely due to environmental decoherence. However, we discuss our results and raise few points, which increase the possibility of interference.

  17. Physical origin of selectivity in ionic channels of biological membranes.

    Science.gov (United States)

    Laio, A; Torre, V

    1999-01-01

    This paper shows that the selectivity properties of monovalent cation channels found in biological membranes can originate simply from geometrical properties of the inner core of the channel without any critical contribution from electrostatic interactions between the permeating ions and charged or polar groups. By using well-known techniques of statistical mechanics, such as the Langevin equations and Kramer theory of reaction rates, a theoretical equation is provided relating the permeability ratio PB/PA between ions A and B to simple physical properties, such as channel geometry, thermodynamics of ion hydration, and electrostatic interactions between the ion and charged (or polar) groups. Diffusive corrections and recrossing rates are also considered and evaluated. It is shown that the selectivity found in usual K+, gramicidin, Na+, cyclic nucleotide gated, and end plate channels can be explained also in the absence of any charged or polar group. If these groups are present, they significantly change the permeability ratio only if the ion at the selectivity filter is in van der Waals contact with them, otherwise these groups simply affect the channel conductance, lowering the free energy barrier of the same amount for the two ions, thus explaining why single channel conductance, as it is experimentally observed, can be very different in channels sharing the same selectivity sequence. The proposed theory also provides an estimate of channel minimum radius for K+, gramicidin, Na+, and cyclic nucleotide gated channels.

  18. Opportunistic relaying in multipath and slow fading channel: Relay selection and optimal relay selection period

    KAUST Repository

    Sungjoon Park,

    2011-11-01

    In this paper we present opportunistic relay communication strategies of decode and forward relaying. The channel that we are considering includes pathloss, shadowing, and fast fading effects. We find a simple outage probability formula for opportunistic relaying in the channel, and validate the results by comparing it with the exact outage probability. Also, we suggest a new relay selection algorithm that incorporates shadowing. We consider a protocol of broadcasting the channel gain of the previously selected relay. This saves resources in slow fading channel by reducing collisions in relay selection. We further investigate the optimal relay selection period to maximize the throughput while avoiding selection overhead. © 2011 IEEE.

  19. Estimation and Direct Equalization of Doubly Selective Channels

    Directory of Open Access Journals (Sweden)

    Leus Geert

    2006-01-01

    Full Text Available We propose channel estimation and direct equalization techniques for transmission over doubly selective channels. The doubly selective channel is approximated using the basis expansion model (BEM. Linear and decision feedback equalizers implemented by time-varying finite impulse response (FIR filters may then be used to equalize the doubly selective channel, where the time-varying FIR filters are designed according to the BEM. In this sense, the equalizer BEM coefficients are obtained either based on channel estimation or directly. The proposed channel estimation and direct equalization techniques range from pilot-symbol-assisted-modulation- (PSAM- based techniques to blind and semiblind techniques. In PSAM techniques, pilot symbols are utilized to estimate the channel or directly obtain the equalizer coefficients. The training overhead can be completely eliminated by using blind techniques or reduced by combining training-based techniques with blind techniques resulting in semiblind techniques. Numerical results are conducted to verify the different proposed channel estimation and direct equalization techniques.

  20. Game Theory-based Channel Selection for LTE-U

    OpenAIRE

    Ciccarelli, Enrico

    2016-01-01

    The Project intends to analyse the performance of a game theory-based channel selection in LTE-U. The main topic of this thesis project is the study of a channel selection strategy for LTE-U based on the game theory. The method consists on a repeated game where each small cell is a player with the purpose of finding the best channel where to set up the LTE-U carrier and it uses the ITEL-BA algorithm in order to make the system to converge to a Nash Equilibrium state. The aim is to evaluate...

  1. Towards low power N-Path filters for flexible RF-Channel selection

    NARCIS (Netherlands)

    Klumperink, Eric A.M.; Soer, M.C.M.; Struiksma, R.E.; van Vliet, Frank Edward; Nauta, Bram

    2015-01-01

    N-path filters can offer high-linearity high-Q channel selection filtering at a flexibly programmable RF center frequency, which is highly wanted for Software Defined Radio. Relying on capacitors and MOSFET switches, driven by digital non-overlapping clocks, N-path filters fit well to CMOS and

  2. Towards Low Power N-Path filters for flexible RF-channel selection

    NARCIS (Netherlands)

    Klumperink, Eric A.M.; Soer, M.C.M.; Struiksma, R.E.; van Vliet, Frank Edward; Nauta, Bram

    2015-01-01

    N-path filters can offer high-linearity high-Q channel selection filtering at a flexibly programmable RF center frequency, which is highly wanted for Software Defined Radio. Relying on capacitors and MOSFET switches, driven by digital non-overlapping clocks, N-path filters fit well to CMOS and

  3. Dynamic Channel Selection for Cognitive Femtocells

    DEFF Research Database (Denmark)

    Da Costa, Gustavo Wagner Oliveira; Cattoni, Andrea Fabio; Mogensen, Preben

    2014-01-01

    , but not least, the possibility of having closed-subscriber-groups aggravates the inter-cell interference problems. In order to tackle these issues we consider the implementation of some aspects of cognitive radio technology into femtocells, leading to the concept of cognitive femtocells. This chapter focuses...... on state-of-art techniques to manage the radio resources in order to cope with inter-cell interference in cognitive femtocells. Different techniques are presented as examples of gradually increasing sophistication of the cognitive femtocells, allowing for dynamic channel allocation, dynamic reuse...... the traditional planning and optimization techniques. This leads to uncoordinated deployment by the end-user. Second, the high density of femtocells, including vertical reuse, leads to very different inter-cell interference patterns than the ones traditionally considered in cellular networks. And last...

  4. A Framework for Selection of Intermediary in Marketing Channel

    Directory of Open Access Journals (Sweden)

    Gholamreza Jandaghi

    2016-07-01

    Full Text Available Purpose – This study seeks to examine how company can select the best intermediary for its Marketing channels with minimum of criteria and time. Design/methodology/approach – A theoretical framework is proposed based on the mostimportance tasks of intermediary and criteria for measuring them. There are four basic tasks and 30 criteria in three independent levels. Subsequently, an exploratory case study in Iranian Food industry is described that illustrates the value of the framework. Findings – It is possible, for example, to apply the theoretical framework to select the intermediary for any industry or any country. Research limitations/implications – The study has possible location- and industry-specific limitations.Originality/value – Moreover, the framework has proven to be useful in improving the selection of the intermediary in marketing channel. This is a notable and promising side-effect of the exploratory study, at least from a managerial point of view.Keywords: Marketing channel, Distribution channel, Channel design, Selection criteria, channel members, Intermediary selection

  5. Maximum-Likelihood Semiblind Equalization of Doubly Selective Channels Using the EM Algorithm

    Directory of Open Access Journals (Sweden)

    Gideon Kutz

    2010-01-01

    Full Text Available Maximum-likelihood semi-blind joint channel estimation and equalization for doubly selective channels and single-carrier systems is proposed. We model the doubly selective channel as an FIR filter where each filter tap is modeled as a linear combination of basis functions. This channel description is then integrated in an iterative scheme based on the expectation-maximization (EM principle that converges to the channel description vector estimation. We discuss the selection of the basis functions and compare various functions sets. To alleviate the problem of convergence to a local maximum, we propose an initialization scheme to the EM iterations based on a small number of pilot symbols. We further derive a pilot positioning scheme targeted to reduce the probability of convergence to a local maximum. Our pilot positioning analysis reveals that for high Doppler rates it is better to spread the pilots evenly throughout the data block (and not to group them even for frequency-selective channels. The resulting equalization algorithm is shown to be superior over previously proposed equalization schemes and to perform in many cases close to the maximum-likelihood equalizer with perfect channel knowledge. Our proposed method is also suitable for coded systems and as a building block for Turbo equalization algorithms.

  6. NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels

    NARCIS (Netherlands)

    Senatore, A.; Monteil, A.; van Minnen, J.; Smit, A.B.; Spafford, J.D.

    2013-01-01

    NALCN is a member of the family of ion channels with four homologous, repeat domains that include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene from simple, extant multicellular organisms without nervous systems such as sponges and placozoans and mostly remains a single

  7. Algorithm Design for Assignment Frequency Channels for Services in CATV Network

    Directory of Open Access Journals (Sweden)

    Jan Hlubik

    2008-01-01

    Full Text Available This article describes algorithm design for assignment frequency channels for services in CATV network. QAM modulated channels in designed system are dynamically switched and frequency adapted. On introduction, there is shortly described principle of providing analog video, digital video and data services in CATV network. Object of the article is focused on method of allocation individual TV and data channels on the frequency band. The conclusion compares advantages and disadvantages present and design system.

  8. The effect of inundation frequency on ground beetle communities in a channelized mountain stream

    Science.gov (United States)

    Skalski, T.; Kedzior, R.; Radecki-Pawlik, A.

    2012-04-01

    Under natural conditions, river channels and floodplains are shaped by flow and sediment regime and are one of the most dynamic ecosystems. At present, European river floodplains are among the most endangered landscapes due to human modifications to river systems, including channel regulation and floodplain urbanization, and land use changes in the catchments. Situated in a transition zone between terrestrial and aquatic environments, exposed riverine sediments (ERS) play a key role in the functioning of riverine ecosystems. This study aimed to verify whether the bare granular substrate is the only factor responsible for sustaining the biota associated with ERS or the inundation frequency also plays a role, modifying the potential of particular species to colonize these habitats. Ground beetles (Col. Carabidae) were selected as the investigated group of organisms and the study was carried out in Porębianka, a Polish Carpathian stream flowing through both unconstrained channel sections and sections with varied channelization schemes (rapid hydraulic structures, concrete revetments or rip-rap of various age). In each of the distinguished channel types, four replicates of 10 pitfall traps were established in three rows varying in distance to the mean water level (at three different benches). Almost 7000 individuals belonging to 102 species were collected on 60 plots. Forward selection of redundancy analysis revealed four factors significantly describing the variation in ground beetle species data: bank modification, potential bankfull discharge, frequency of inundation and plant height. Most of the biggest species were ordered at the positive site of first axis having the highest values of periods between floods. Total biomass of ground beetles and mean biomass of individuals differed significantly between sites of various frequency of inundation, whereas the variation in abundance and species richness of ground beetles was independent of the river dynamics. The body

  9. OPRA capacity bounds for selection diversity over generalized fading channels

    KAUST Repository

    Hanif, Muhammad Fainan

    2014-05-01

    Channel side information at the transmitter can increase the average capacity by enabling optimal power and rate adaptation. The resulting optimal power and rate adaptation (OPRA) capacity rarely has a closed-form analytic expression. In this paper, lower and upper bounds on OPRA capacity for selection diversity scheme are presented. These bounds hold for variety of fading channels including log-normal and generalized Gamma distributed models and have very simple analytic expressions for easy evaluation even for kth best path selection. Some selected numerical results show that the newly proposed bounds closely approximate the actual OPRA capacity. © 2014 IEEE.

  10. Block Transmissions over Doubly Selective Channels : Iterative Channel Estimation and Turbo Equalization

    NARCIS (Netherlands)

    Fang, K.; Rugini, L.; Leus, G.

    2010-01-01

    Modern wireless communication systems require high transmission rates, giving rise to frequency selectivity due to multipath propagation. In addition, high-mobility terminals and scatterers induce Doppler shifts that introduce time selectivity. Therefore, advanced techniques are needed to accurately

  11. An Adaptive Channel Estimation Algorithm Using Time-Frequency Polynomial Model for OFDM with Fading Multipath Channels

    Directory of Open Access Journals (Sweden)

    Liu KJ Ray

    2002-01-01

    Full Text Available Orthogonal frequency division multiplexing (OFDM is an effective technique for the future 3G communications because of its great immunity to impulse noise and intersymbol interference. The channel estimation is a crucial aspect in the design of OFDM systems. In this work, we propose a channel estimation algorithm based on a time-frequency polynomial model of the fading multipath channels. The algorithm exploits the correlation of the channel responses in both time and frequency domains and hence reduce more noise than the methods using only time or frequency polynomial model. The estimator is also more robust compared to the existing methods based on Fourier transform. The simulation shows that it has more than improvement in terms of mean-squared estimation error under some practical channel conditions. The algorithm needs little prior knowledge about the delay and fading properties of the channel. The algorithm can be implemented recursively and can adjust itself to follow the variation of the channel statistics.

  12. Eight-channel reconfigurable microring filters with tunable frequency, extinction ratio and bandwidth.

    Science.gov (United States)

    Shen, Hao; Khan, Maroof H; Fan, Li; Zhao, Lin; Xuan, Yi; Ouyang, Jing; Varghese, Leo T; Qi, Minghao

    2010-08-16

    We demonstrate an eight-channel reconfigurable optical filter on a silicon chip. It consists of cascaded microring resonators and integrated compact heaters. With an embedded Mach-Zehnder (MZ) arm coupling to a microring resonator, the important parameters of a filter such as center frequency, extinction ratio and bandwidth can be controlled simultaneously for purposes of filtering, routing and spectral shaping. Thus our device could potentially be useful in dense wavelength division multiplexing (DWDM) and radio frequency arbitrary waveform generation (RFAWG). Multichannel filter response was successfully tuned to match the International Telecommunication Unit (ITU) grid with 50, 100 and 200 GHz in channel spacing. Programmable channel selectivity was demonstrated by heating the MZ arm, and continuous adjustment of through-port extinction ratio from 0 dB to 27 dB was achieved. Meanwhile, the 3 dB bandwidth in the drop port changed from 0.12 nm to 0.16 nm. The device had an ultra-compact footprint (1200 microm x 100 microm) excluding the metal leads and contact pads, making it suitable for large scale integration.

  13. A study of the impact of frequency selectivity on link adaptive wireless LAN systems

    OpenAIRE

    Armour, SMD; Doufexi, A; Nix, AR; Bull, DR

    2002-01-01

    Wireless local area networks (WLANs) supporting broadband multimedia communication are being developed and standardized around the world. The HIPERLAN/2, 802.11a and HiSWANa standards provide channel adaptive data rates between 6 and 54 Mbps in the 5GHz radio band. The link adaptation mechanism is not specified in the standards. In this paper the performance of the HIPERLAN/2 system is evaluated in terms of throughput in a range of test channels with different degrees of frequency selectivity...

  14. Frequency width of open channels in multiple scattering media

    NARCIS (Netherlands)

    Bosch, J.; Goorden, S.A.; Mosk, Allard

    2016-01-01

    We report optical measurements of the spectral width of open transmission channels in a three-dimensional diffusive medium. The light transmission through a sample is enhanced by efficiently coupling to open transmission channels using repeated digital optical phase conjugation. The spectral

  15. Frequency Selective Surface for Structural Health Monitoring

    Science.gov (United States)

    Norlyana Azemi, Saidatul; Mustaffa, Farzana Hazira Wan; Faizal Jamlos, Mohd; Abdullah Al-Hadi, Azremi; Soh, Ping Jack

    2018-03-01

    Structural health monitoring (SHM) technologies have attained attention to monitor civil structures. SHM sensor systems have been used in various civil structures such as bridges, buildings, tunnels and so on. However the previous sensor for SHM is wired and encounter with problem to cover large areas. Therefore, wireless sensor was introduced for SHM to reduce network connecting problem. Wireless sensors for Structural Health monitoring are new technology and have many advantages to overcome the drawback of conventional and wired sensor. This project proposed passive wireless SHM sensor using frequency selective surface (FSS) as an alternative to conventional sensors. The electromagnetic wave characteristic of FSS will change by geometrical changes of FSS due to mechanical strain or structural failure. The changes feature is used as a sensing function without any connecting wires. Two type of design which are circular ring and square loop along with the transmission and reflection characteristics of SHM using FSS were discussed in this project. A simulation process has shown that incident angle characteristics can be use as a data for SHM application.

  16. Bandwidth efficient channel estimation method for airborne hyperspectral data transmission in sparse doubly selective communication channels

    Science.gov (United States)

    Vahidi, Vahid; Saberinia, Ebrahim; Regentova, Emma E.

    2017-10-01

    A channel estimation (CE) method based on compressed sensing (CS) is proposed to estimate the sparse and doubly selective (DS) channel for hyperspectral image transmission from unmanned aircraft vehicles to ground stations. The proposed method contains three steps: (1) the priori estimate of the channel by orthogonal matching pursuit (OMP), (2) calculation of the linear minimum mean square error (LMMSE) estimate of the received pilots given the estimated channel, and (3) estimate of the complex amplitudes and Doppler shifts of the channel using the enhanced received pilot data applying a second round of a CS algorithm. The proposed method is named DS-LMMSE-OMP, and its performance is evaluated by simulating transmission of AVIRIS hyperspectral data via the communication channel and assessing their fidelity for the automated analysis after demodulation. The performance of the DS-LMMSE-OMP approach is compared with that of two other state-of-the-art CE methods. The simulation results exhibit up to 8-dB figure of merit in the bit error rate and 50% improvement in the hyperspectral image classification accuracy.

  17. A Triply Selective MIMO Channel Simulator Using GPUs

    Directory of Open Access Journals (Sweden)

    R. Carrasco-Alvarez

    2018-01-01

    Full Text Available A methodology for implementing a triply selective multiple-input multiple-output (MIMO simulator based on graphics processing units (GPUs is presented. The resulting simulator is based on the implementation of multiple double-selective single-input single-output (SISO channel generators, where the multiple inputs and the multiple received signals have been transformed in order to supply the corresponding space correlation of the channel under consideration. A direct consequence of this approach is the flexibility provided, which allows different propagation statistics to each SISO channel to be specified and thus more complex environments to be replicated. It is shown that under some specific constraints, the statistics of the triply selective MIMO simulator are the same as those reported in the state of art. Simulation results show the computational time improvement achieved, up to 650-fold for an 8 × 8 MIMO channel simulator when compared with sequential implementations. In addition to the computational improvement, the proposed simulator offers flexibility for testing a variety of scenarios in vehicle-to-vehicle (V2V and vehicle-to-infrastructure (V2I systems.

  18. Develop A Framework for Selection of Intermediary in Marketing Channel

    Directory of Open Access Journals (Sweden)

    Hamid Reza Irani

    2011-03-01

    Full Text Available This study seeks to examine how a company can select the best intermediary for itsMarketing channels with minimum of criteria and time. A theoretical framework is proposed basedon the most important tasks of intermediary and the criteria to measure them. There are four basictasks and thirty criteria in three independent levels. Subsequently, an exploratory case study inIranian Food industry is described to illustrate the value of the framework. It is possible to apply thetheoretical framework to select the intermediary for any industry or country. However, there mightbe possible location-specific or industry-specific limitations. Moreover, the framework has provedto be useful in improving the selection of the intermediary in marketing channel. This is a notableand promising side-effect of the exploratory study, at least from a managerial point of view.

  19. Analytic clock frequency selection for global DVFS

    NARCIS (Netherlands)

    Gerards, Marco Egbertus Theodorus; Hurink, Johann L.; Holzenspies, P.K.F.; Kuper, Jan; Smit, Gerardus Johannes Maria

    2014-01-01

    Computers can reduce their power consumption by decreasing their speed using Dynamic Voltage and Frequency Scaling (DVFS). A form of DVFS for multicore processors is global DVFS, where the voltage and clock frequency is shared among all processor cores. Because global DVFS is efficient and cheap to

  20. Raman scattering of a photon with frequency doubling by a channelled positron

    Energy Technology Data Exchange (ETDEWEB)

    Kalashnikov, N P [National Research Nuclear University ' ' MEPhI' ' (Russian Federation); Krokhin, O N [P N Lebedev Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation)

    2014-12-31

    We have analysed the possibility of appearance of anti-Stokes lines in the spectrum of Raman scattering of a photon by a 'quasi-bound' charged particle in the regime of planar (axial) channelling. It is shown that radiation may emerge at the frequency, which is a combination of the incident photon frequency ω{sub 0} and transition frequency ω{sub i} in the transverse quantised motion of a channelled particle: ω = ω{sub 0} ± 2γ{sup 2}ω{sub i}, where γ is the relativistic (Lorentz) factor of a channelled particle. (nonlinear optical phenomena)

  1. Protein structure and ionic selectivity in calcium channels: Selectivity filter size, not shape, matters

    OpenAIRE

    Malasics, Attila; Gillespie, Dirk; Nonner, Wolfgang; Henderson, Douglas; Eisenberg, Bob; Boda, Dezső

    2009-01-01

    Calcium channels have highly charged selectivity filters (4 COO− groups) that attract cations in to balance this charge and minimize free energy, forcing the cations (Na+ and Ca2+) to compete for space in the filter. A reduced model was developed to better understand the mechanism of ion selectivity in calcium channels. The charge/space competition (CSC) mechanism implies that Ca2+ is more efficient in balancing the charge of the filter because it provides twice the charge as Na+ while occupy...

  2. Channel Islands, Kelp Forest Monitoring, Size and Frequency, Natural Habitat, 1985-2007

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has measurements of the size of selected animal species at selected locations in the Channel Islands National Park. Sampling is conducted annually...

  3. Compensation of frequency selectivity and antenna effect for the energy detection Gaussian frequency-shift keying ultra-wideband system

    Directory of Open Access Journals (Sweden)

    Song Cui

    2016-03-01

    Full Text Available The energy detection (ED Gaussian frequency-shift keying (GFSK ultra-wideband (UWB system, transmits bit 0 and 1 using different-order derivatives of the Gaussian pulse. The spectra of the two pulses are separated entirely in the frequency domain, so it generates the orthogonality of these two pulses. This orthogonality in the frequency domain makes the GFSK system more robust in multipath channels and in the presence of synchronisation errors, so it shows a better bit error rate performance than the ED pulse-position modulation UWB system. However, the effect of frequency selectivity and antenna has not been discussed in earlier publications. In this study, the authors will analyse the effect of these two factors and propose a method to compensate the effect.

  4. Unification of Frequency direction Pilot-symbol Aided Channel Estimation (PACE) for OFDM

    DEFF Research Database (Denmark)

    Rom, Christian; Manchón, Carles Navarro; Deneire, Luc

    2007-01-01

    Frequency direction Pilot-symbol Aided Channel Estimation (PACE) for Orthogonal Frequency Division Multiplexing (OFDM) is crucial in high-rate wireless systems. The choice of an estimator for upcoming standards, such as the Long Term Evolution (LTE) of UTRA, has to take into account their specifi......Frequency direction Pilot-symbol Aided Channel Estimation (PACE) for Orthogonal Frequency Division Multiplexing (OFDM) is crucial in high-rate wireless systems. The choice of an estimator for upcoming standards, such as the Long Term Evolution (LTE) of UTRA, has to take into account...

  5. Wavelet Packet Feature Assessment for High-Density Myoelectric Pattern Recognition and Channel Selection toward Stroke Rehabilitation.

    Science.gov (United States)

    Wang, Dongqing; Zhang, Xu; Gao, Xiaoping; Chen, Xiang; Zhou, Ping

    2016-01-01

    This study presents wavelet packet feature assessment of neural control information in paretic upper limb muscles of stroke survivors for myoelectric pattern recognition, taking advantage of high-resolution time-frequency representations of surface electromyogram (EMG) signals. On this basis, a novel channel selection method was developed by combining the Fisher's class separability index and the sequential feedforward selection analyses, in order to determine a small number of appropriate EMG channels from original high-density EMG electrode array. The advantages of the wavelet packet features and the channel selection analyses were further illustrated by comparing with previous conventional approaches, in terms of classification performance when identifying 20 functional arm/hand movements implemented by 12 stroke survivors. This study offers a practical approach including paretic EMG feature extraction and channel selection that enables active myoelectric control of multiple degrees of freedom with paretic muscles. All these efforts will facilitate upper limb dexterity restoration and improved stroke rehabilitation.

  6. A Method for Dynamically Selecting the Best Frequency Hopping Technique in Industrial Wireless Sensor Network Applications.

    Science.gov (United States)

    Fernández de Gorostiza, Erlantz; Berzosa, Jorge; Mabe, Jon; Cortiñas, Roberto

    2018-02-23

    Industrial wireless applications often share the communication channel with other wireless technologies and communication protocols. This coexistence produces interferences and transmission errors which require appropriate mechanisms to manage retransmissions. Nevertheless, these mechanisms increase the network latency and overhead due to the retransmissions. Thus, the loss of data packets and the measures to handle them produce an undesirable drop in the QoS and hinder the overall robustness and energy efficiency of the network. Interference avoidance mechanisms, such as frequency hopping techniques, reduce the need for retransmissions due to interferences but they are often tailored to specific scenarios and are not easily adapted to other use cases. On the other hand, the total absence of interference avoidance mechanisms introduces a security risk because the communication channel may be intentionally attacked and interfered with to hinder or totally block it. In this paper we propose a method for supporting the design of communication solutions under dynamic channel interference conditions and we implement dynamic management policies for frequency hopping technique and channel selection at runtime. The method considers several standard frequency hopping techniques and quality metrics, and the quality and status of the available frequency channels to propose the best combined solution to minimize the side effects of interferences. A simulation tool has been developed and used in this work to validate the method.

  7. Optimization of a digital lock-in algorithm with a square-wave reference for frequency-divided multi-channel sensor signal detection.

    Science.gov (United States)

    Zhang, Shengzhao; Li, Gang; Lin, Ling; Zhao, Jing

    2016-08-01

    A digital lock-in detection technique is commonly used to measure the amplitude and phase of a selected frequency signal. A technique that uses a square wave as the reference signal has an advantage over the one using a sinusoidal wave due to its easier implementation and higher computational efficiency. However, demodulating multiple-frequency composite signals using square wave reference may result in interference between channels. To avoid interference between channels and reduce the computational complexity, we modify the calculations and determine the optimal parameter settings of the low-pass filter and carrier frequency, as detailed in this paper. The results of our analysis show that when the length of the average filter and carrier frequencies are properly set, the interference between the channels is removed. This optimization produces the digital lock-in detection suitable for measuring multi-channel sensor signals.

  8. Specification for Digital Channel Selection Filters in a Bluetooth Capable HiperLAN/2 Receiver

    NARCIS (Netherlands)

    Hoeksema, F.W.; Schiphorst, Roelof; Slump, Cornelis H.

    2002-01-01

    In this paper we first briefly describe how the analog part of the channel selection function for a HiperLAN/2 receiver can be used as part of the channel selection function for a Bluetooth receiver. Thereafter we proceed to specify the overall requirements for the Bluetooth channel selection

  9. Channel Selection Based on Trust and Multiarmed Bandit in Multiuser, Multichannel Cognitive Radio Networks

    Directory of Open Access Journals (Sweden)

    Fanzi Zeng

    2014-01-01

    Full Text Available This paper proposes a channel selection scheme for the multiuser, multichannel cognitive radio networks. This scheme formulates the channel selection as the multiarmed bandit problem, where cognitive radio users are compared to the players and channels to the arms. By simulation negotiation we can achieve the potential reward on each channel after it is selected for transmission; then the channel with the maximum accumulated rewards is formally chosen. To further improve the performance, the trust model is proposed and combined with multi-armed bandit to address the channel selection problem. Simulation results validate the proposed scheme.

  10. Channel selection based on trust and multiarmed bandit in multiuser, multichannel cognitive radio networks.

    Science.gov (United States)

    Zeng, Fanzi; Shen, Xinwang

    2014-01-01

    This paper proposes a channel selection scheme for the multiuser, multichannel cognitive radio networks. This scheme formulates the channel selection as the multiarmed bandit problem, where cognitive radio users are compared to the players and channels to the arms. By simulation negotiation we can achieve the potential reward on each channel after it is selected for transmission; then the channel with the maximum accumulated rewards is formally chosen. To further improve the performance, the trust model is proposed and combined with multi-armed bandit to address the channel selection problem. Simulation results validate the proposed scheme.

  11. Frequency selective bistable switching in metamaterial based photonic bandgap medium

    Science.gov (United States)

    Jose, Jolly

    2014-10-01

    We present frequency selective bistable response at the defect mode of the zero-nbar bandgap of a photonic bandgap (PBG) material made of negative and positive index media. The nonlinear (Kerr) layer acts as the defect layer in the periodic PBG material. Incorporating metamaterial based electromagnetically induced transparency (EIT) like resonance in the positive layer leads to unprecedented line narrowing of the defect mode which in turn facilitates narrow frequency selective bistable operation, wherein all the bistable characteristics can be effectively engineered. Thresholding the output intensity selects the narrow band of frequencies that exhibit bistability.

  12. Frequency-Selective Attention in Auditory Scenes Recruits Frequency Representations Throughout Human Superior Temporal Cortex.

    Science.gov (United States)

    Riecke, Lars; Peters, Judith C; Valente, Giancarlo; Kemper, Valentin G; Formisano, Elia; Sorger, Bettina

    2017-05-01

    A sound of interest may be tracked amid other salient sounds by focusing attention on its characteristic features including its frequency. Functional magnetic resonance imaging findings have indicated that frequency representations in human primary auditory cortex (AC) contribute to this feat. However, attentional modulations were examined at relatively low spatial and spectral resolutions, and frequency-selective contributions outside the primary AC could not be established. To address these issues, we compared blood oxygenation level-dependent (BOLD) responses in the superior temporal cortex of human listeners while they identified single frequencies versus listened selectively for various frequencies within a multifrequency scene. Using best-frequency mapping, we observed that the detailed spatial layout of attention-induced BOLD response enhancements in primary AC follows the tonotopy of stimulus-driven frequency representations-analogous to the "spotlight" of attention enhancing visuospatial representations in retinotopic visual cortex. Moreover, using an algorithm trained to discriminate stimulus-driven frequency representations, we could successfully decode the focus of frequency-selective attention from listeners' BOLD response patterns in nonprimary AC. Our results indicate that the human brain facilitates selective listening to a frequency of interest in a scene by reinforcing the fine-grained activity pattern throughout the entire superior temporal cortex that would be evoked if that frequency was present alone. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  13. On Optimal Input Design and Model Selection for Communication Channels

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yanyan [ORNL; Djouadi, Seddik M [ORNL; Olama, Mohammed M [ORNL

    2013-01-01

    In this paper, the optimal model (structure) selection and input design which minimize the worst case identification error for communication systems are provided. The problem is formulated using metric complexity theory in a Hilbert space setting. It is pointed out that model selection and input design can be handled independently. Kolmogorov n-width is used to characterize the representation error introduced by model selection, while Gel fand and Time n-widths are used to represent the inherent error introduced by input design. After the model is selected, an optimal input which minimizes the worst case identification error is shown to exist. In particular, it is proven that the optimal model for reducing the representation error is a Finite Impulse Response (FIR) model, and the optimal input is an impulse at the start of the observation interval. FIR models are widely popular in communication systems, such as, in Orthogonal Frequency Division Multiplexing (OFDM) systems.

  14. Protein structure and ionic selectivity in calcium channels: selectivity filter size, not shape, matters.

    Science.gov (United States)

    Malasics, Attila; Gillespie, Dirk; Nonner, Wolfgang; Henderson, Douglas; Eisenberg, Bob; Boda, Dezso

    2009-12-01

    Calcium channels have highly charged selectivity filters (4 COO(-) groups) that attract cations in to balance this charge and minimize free energy, forcing the cations (Na(+) and Ca(2+)) to compete for space in the filter. A reduced model was developed to better understand the mechanism of ion selectivity in calcium channels. The charge/space competition (CSC) mechanism implies that Ca(2+) is more efficient in balancing the charge of the filter because it provides twice the charge as Na(+) while occupying the same space. The CSC mechanism further implies that the main determinant of Ca(2+) versus Na(+) selectivity is the density of charged particles in the selectivity filter, i.e., the volume of the filter (after fixing the number of charged groups in the filter). In this paper we test this hypothesis by changing filter length and/or radius (shape) of the cylindrical selectivity filter of our reduced model. We show that varying volume and shape together has substantially stronger effects than varying shape alone with volume fixed. Our simulations show the importance of depletion zones of ions in determining channel conductance calculated with the integrated Nernst-Planck equation. We show that confining the protein side chains with soft or hard walls does not influence selectivity.

  15. Like/dislike analysis using EEG: determination of most discriminative channels and frequencies.

    Science.gov (United States)

    Yılmaz, Bülent; Korkmaz, Sümeyye; Arslan, Dilek Betül; Güngör, Evrim; Asyalı, Musa H

    2014-02-01

    In this study, we have analyzed electroencephalography (EEG) signals to investigate the following issues, (i) which frequencies and EEG channels could be relatively better indicators of preference (like or dislike decisions) of consumer products, (ii) timing characteristic of "like" decisions during such mental processes. For this purpose, we have obtained multichannel EEG recordings from 15 subjects, during total of 16 epochs of 10 s long, while they were presented with some shoe photographs. When they liked a specific shoe, they pressed on a button and marked the time of this activity and the particular epoch was labeled as a LIKE case. No button press meant that the subject did not like the particular shoe that was displayed and corresponding epoch designated as a DISLIKE case. After preprocessing, power spectral density (PSD) of EEG data was estimated at different frequencies (4, 5, …, 40 Hz) using the Burg method, for each epoch corresponding to one shoe presentation. Each subject's data consisted of normalized PSD values (NPVs) from all LIKE and DISLIKE cases/epochs coming from all 19 EEG channels. In order to determine the most discriminative frequencies and channels, we have utilized logistic regression, where LIKE/DISLIKE status was used as a categorical (binary) response variable and corresponding NPVs were the continuously valued input variables or predictors. We observed that when all the NPVs (total of 37) are used as predictors, the regression problem was becoming ill-posed due to large number of predictors (compared to the number of samples) and high correlation among predictors. To circumvent this issue, we have divided the frequency band into low frequency (LF) 4-19 Hz and high frequency (HF) 20-40 Hz bands and analyzed the influence of the NPV in these bands separately. Then, using the p-values that indicate how significantly estimated predictor weights are different than zero, we have determined the NPVs and channels that are more influential

  16. Wavelength- and Time-Selective Reconfigurable Optical Add/Drop Multiplexer Using Time-Frequency Domain Processing

    Directory of Open Access Journals (Sweden)

    Konishi Tsuyoshi

    2010-01-01

    Full Text Available We propose and demonstrate a wavelength- and time-selective reconfigurable optical add/drop multiplexer (ROADM using time-frequency domain processing. The proposed ROADM is realized by allocating wavelength channels and time slots to corresponding 2D spatial channels on a MEMS optical switch. Experimental results show the wavelength- and time-selective drop operation for a signal with equivalent 3.2 Tb/s (0.64  channels, and the reconfigurability by the switching operation of the MEMS optical switch.

  17. Wavelength- and Time-Selective Reconfigurable Optical Add/Drop Multiplexer Using Time-Frequency Domain Processing

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Konishi

    2010-01-01

    Full Text Available We propose and demonstrate a wavelength- and time-selective reconfigurable optical add/drop multiplexer (ROADM using time-frequency domain processing. The proposed ROADM is realized by allocating wavelength channels and time slots to corresponding 2D spatial channels on a MEMS optical switch. Experimental results show the wavelength- and time-selective drop operation for a signal with equivalent 3.2 Tb/s (0.64 Tb/s×5 channels, and the reconfigurability by the switching operation of the MEMS optical switch.

  18. Histamine selectively potentiates acid-sensing ion channel 1a.

    Science.gov (United States)

    Nagaeva, Elina I; Tikhonova, Tatiana B; Magazanik, Lev G; Tikhonov, Denis B

    2016-10-06

    Although acid-sensitive ion channels (ASICs) play an important role in brain functions, the exact mechanism of their physiological activation remain unclear. A possible answer to the intriguing question is that some presently unknown endogenous ligand(s) positively modulate ASICs and enhance their responses to physiologically significant level. In the present work we found that histamine selectively potentiates ASIC1a homomers in CHO cells. Action of histamine was particularly pronounced at modest acidifications, which cause minor response. At these conditions micromolar concentrations of histamine have provided significant potentiation of ASIC1a response. We proposed that histamine and possibly some other endogenous amines can positively modulate ASICs functions. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. An integrative time-varying frequency detection and channel sounding method for dynamic plasma sheath

    Science.gov (United States)

    Shi, Lei; Yao, Bo; Zhao, Lei; Liu, Xiaotong; Yang, Min; Liu, Yanming

    2018-01-01

    The plasma sheath-surrounded hypersonic vehicle is a dynamic and time-varying medium and it is almost impossible to calculate time-varying physical parameters directly. The in-fight detection of the time-varying degree is important to understand the dynamic nature of the physical parameters and their effect on re-entry communication. In this paper, a constant envelope zero autocorrelation (CAZAC) sequence based on time-varying frequency detection and channel sounding method is proposed to detect the plasma sheath electronic density time-varying property and wireless channel characteristic. The proposed method utilizes the CAZAC sequence, which has excellent autocorrelation and spread gain characteristics, to realize dynamic time-varying detection/channel sounding under low signal-to-noise ratio in the plasma sheath environment. Theoretical simulation under a typical time-varying radio channel shows that the proposed method is capable of detecting time-variation frequency up to 200 kHz and can trace the channel amplitude and phase in the time domain well under -10 dB. Experimental results conducted in the RF modulation discharge plasma device verified the time variation detection ability in practical dynamic plasma sheath. Meanwhile, nonlinear phenomenon of dynamic plasma sheath on communication signal is observed thorough channel sounding result.

  20. MONETARY TRANSMISSION CHANNELS IN FLEXIBLE MONETARY AND EXCHANGE RATE REGIMES: THE CASE OF SELECTED TRANSITION ECONOMIES

    Directory of Open Access Journals (Sweden)

    Kosta JOSIFIDIS

    2010-01-01

    Full Text Available The paper explores selected monetary transmission channels in the case of transition economies. Namely, an exchange rate channel, an interest rate channel, direct and indirect influence to an exchange rate, are focused. Specific (former transition economies are differentiated according the combination of implemented monetary and exchange rate regimes: exchange rate as a nominal anchor and rigid exchange rate regimes, exchange rate as a nominal anchor and intermediate exchange rate regimes, and implicit/explicit inflation targeting monetary regime and floating (managed/free exchange rate regime. The monetary transmission is tracked during different phases in a transition process towards the EU and compared between different nominal anchors and exchange rate regimes. In order to track the influence of a monetary policy instruments (impulses to different goals of a monetary policy (responses during the period from 6-24 months, we use VAR and VEC models. Monthly frequency of following time series are used in the models: nominal exchange rates, consumer price indexes, foreign exchange reserves, and reference interest rates. The aim of the paper is to point to the distinction between de jure and de facto exchange rate regimes, and to the adequacy of used combination of monetary and exchange rate regimes having in mind revealed features of investigated monetary transmission channels.

  1. Update on the frequency of Ile1016 mutation in voltage-gated sodium channel gene of Aedes aegypti in Mexico.

    Science.gov (United States)

    Siller, Quetzaly; Ponce, Gustavo; Lozano, Saul; Flores, Adriana E

    2011-12-01

    We analyzed 790 Aedes aegypti from 14 localities of Mexico in 2009 to update information on the frequency of the Ile1016 allele in the voltage-gated sodium channel gene that confers resistance to pyrethroids and DDT. The Ile1016 mutation was present in all 17 collections, and was close to fixation in Acapulco (frequency = 0.97), Iguala (0.93), and San Nicolas (0.90). Genotypes at the 1016 locus were not in Hardy-Weinberg proportions in collections from Panuco, Veracruz, Cosoleacaque, Coatzacoalcos, Tantoyuca, and Monterrey due in every case to an excess of homozygotes. The high frequencies of this mutation in Ae. aegypti are probably due to selection pressure from pyrethroid insecticides, particularly permethrin, which has been used in mosquito control programs for >10 years in Mexico.

  2. Simultaneous multi-band channel sounding at mm-Wave frequencies

    DEFF Research Database (Denmark)

    Müller, Robert; Häfner, Stephan; Dupleich, Diego

    2016-01-01

    and verification of those novel technologies required an understanding of the propagation effects at mm-Wave which enabled by channel sounding measurements and analysis. Due to the variety of considered frequency bands and the necessity of spatial resolved measurements for e.g. testing of beamforming approaches...

  3. Frequency Invariant Uniform Circular Array for Wideband mm-Wave Channel Characterization

    DEFF Research Database (Denmark)

    Zhang, Fengchun; Fan, Wei; Pedersen, Gert F.

    2016-01-01

    A new approach for designing frequency invariant (FI) uniform circular array (UCA) is proposed, and its application to wideband multipath estimation at millimeter wave bands is studied. Both numerical simulations and channel sounding results at mm-Wave bands are provided to demonstrate...

  4. Development of a Flow Injection Based High Frequency Dual Channel Quartz Crystal Microbalance

    Directory of Open Access Journals (Sweden)

    Jinxing Liang

    2017-05-01

    Full Text Available When the quartz crystal microbalance (QCM is used in liquid for adsorption or desorption monitoring based bio- or chemical sensing applications, the frequency shift is not only determined by the surface mass change, but also by the change of liquid characteristics, such as density and viscosity, which are greatly affected by the liquid environmental temperature. A monolithic dual-channel QCM is designed and fabricated by arranging two QCM resonators on one single chip for cancelling the fluctuation induced by environmental factors. In actual applications, one QCM works as a specific sensor by modifying with functional membranes and the other acts as a reference, only measuring the liquid property. The dual-channel QCM is designed with an inverted-mesa structure, aiming to realize a high frequency miniaturized chip and suppress the frequency interference between the neighbored QCM resonators. The key problem of dual-channel QCMs is the interference between two channels, which is influenced by the distance of adjacent resonators. The diameter of the reference electrode has been designed into several values in order to find the optimal parameter. Experimental results demonstrated that the two QCMs could vibrate individually and the output frequency stability and drift can be greatly improved with the aid of the reference QCM.

  5. Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels

    DEFF Research Database (Denmark)

    Diness, Thomas Goldin; Hansen, Rie Schultz; Olesen, Søren-Peter

    2006-01-01

    of the beta-subunits KCNE1 and KCNE2. In addition, the functional role of HERG1 in native guinea pig cardiac myocytes was demonstrated at different pacing frequencies by application of 10microM of the new HERG1 activator, NS1643. In conclusion, we have demonstrated that HERG1 and hKCNQ1 channels are inversely...

  6. Frequency Dependency Analysis of SHF Band Directional Propagation Channel in Indoor Environment

    DEFF Research Database (Denmark)

    Kentaro, Saito; Hanpinitsak, Panawit; Takada, Jun-ichi

    2018-01-01

    In the fifth-generation mobile communication system (5G), the millimeter wave band wireless communication is highly expected that it increases the network capacity drastically. Author's research group has conducted channel measurements in several super high frequency (SHF) bands and investigated ...

  7. Frequency-domain method based on the singular value decomposition for frequency-selective NMR spectroscopy.

    Science.gov (United States)

    Stoica, Petre; Sandgren, Niclas; Selén, Yngve; Vanhamme, Leentje; Van Huffel, Sabine

    2003-11-01

    In several applications of NMR spectroscopy the user is interested only in the components lying in a small frequency band of the spectrum. A frequency selective analysis deals precisely with this kind of NMR spectroscopy: parameter estimation of only those spectroscopic components that lie in a preselected frequency band of the NMR data spectrum, with as little interference as possible from the out-of-band components and in a computationally efficient way. In this paper we introduce a frequency-domain singular value decomposition (SVD)-based method for frequency selective spectroscopy that is computationally simple, statistically accurate, and which has a firm theoretical basis. To illustrate the good performance of the proposed method we present a number of numerical examples for both simulated and in vitro NMR data.

  8. Wavelength-selective fluorescence in ion channels formed by ...

    Indian Academy of Sciences (India)

    TECS

    Abstract. Gramicidins are linear peptides that form ion channels that are specific for monovalent cations in membranes. The tryptophan residues in the gramicidin channel play a crucial role in the orga- nization and function of the channel. The natural mixture of gramicidins, denoted as gramicidin A′, con- sists of mostly ...

  9. Wavelength-selective fluorescence in ion channels formed by ...

    Indian Academy of Sciences (India)

    Gramicidins are linear peptides that form ion channels that are specific for monovalent cations in membranes. The tryptophan residues in the gramicidin channel play a crucial role in the organization and function of the channel. The natural mixture of gramicidins, denoted as gramicidin A', consists of mostly gramicidin A, but ...

  10. Temporal mode selectivity by frequency conversion in second-order nonlinear optical waveguides

    DEFF Research Database (Denmark)

    Reddy, D. V.; Raymer, M. G.; McKinstrie, C. J.

    2013-01-01

    We explore theoretically the feasibility of using frequency conversion by sum- or difference-frequency generation, enabled by three-wave-mixing, for selectively multiplexing orthogonal input waveforms that overlap in time and frequency. Such a process would enable a drop device for use in a trans......We explore theoretically the feasibility of using frequency conversion by sum- or difference-frequency generation, enabled by three-wave-mixing, for selectively multiplexing orthogonal input waveforms that overlap in time and frequency. Such a process would enable a drop device for use...... in a transparent optical network using temporally orthogonal waveforms to encode different channels. We model the process using coupled-mode equations appropriate for wave mixing in a uniform second-order nonlinear optical medium pumped by a strong laser pulse. We find Green functions describing the process......, and employ Schmidt (singular-value) decompositions thereof to quantify its viability in functioning as a coherent waveform discriminator. We define a selectivity figure of merit in terms of the Schmidt coefficients, and use it to compare and contrast various parameter regimes via extensive numerical...

  11. Frequency-comb-referenced multi-channel fiber laser for DWDM communication.

    Science.gov (United States)

    Chun, Byung Jae; Hyun, Sangwon; Kim, Seungman; Kim, Seung-Woo; Kim, Young-Jin

    2013-12-02

    We propose an all-fiber-based multi-channel optical scheme that enables simultaneous generation of multiple continuous-wave laser wavelengths with stabilization to the frequency comb of a femtosecond laser. The intention is to produce highly stable, accurate wavelength channels with immunity to environmental disturbance so as to enhance the transmission capacity of dense wavelength division multiplexing (DWDM) communications. Generated wavelengths lie over a wide spectral range of 5 THz about 1550 nm, each yielding a narrow linewidth of less than 24 kHz with an absolute position uncertainty of ~2.24 × 10¹² (10 s averaging) traceable directly to the atomic Rb clock.

  12. Encoding many channels on the same frequency through radio vorticity: first experimental test

    International Nuclear Information System (INIS)

    Tamburini, Fabrizio; Sponselli, Anna; Bianchini, Antonio; Mari, Elettra; Thidé, Bo; Romanato, Filippo

    2012-01-01

    We have shown experimentally, in a real-world setting, that it is possible to use two beams of incoherent radio waves, transmitted on the same frequency but encoded in two different orbital angular momentum states, to simultaneously transmit two independent radio channels. This novel radio technique allows the implementation of, in principle, an infinite number of channels in a given, fixed bandwidth, even without using polarization, multiport or dense coding techniques. This paves the way for innovative techniques in radio science and entirely new paradigms in radio communication protocols that might offer a solution to the problem of radio-band congestion. (paper)

  13. Electrostatic tuning of permeation and selectivity in aquaporin water channels

    DEFF Research Database (Denmark)

    Jensen, Mogens O Stibius; Tajkhorshid, E.; Schulten, K.

    2003-01-01

    stronger than water-protein interactions, except near a conserved, positively charged Arg residue. We find that variations of the protein electrostatic field through the channel, owing to preserved structural features, completely explain the bipolar orientation of water. This orientation persists despite......Water permeation and electrostatic interactions between water and channel are investigated in the Escherichia coli glycerol uptake facilitator GlpF, a member of the aquaporin water channel family, by molecular dynamics simulations. A tetrameric model of the channel embedded in a 16:0/ 18:1c9......-palmitoyloleylphosphatidylethanolamine membrane was used for the simulations. During the simulations, water molecules pass through the channel in single file. The movement of the single. le water molecules through the channel is concerted, and we show that it can be described by a continuous-time random-walk model. The integrity...

  14. Multiple flow profiles for two-phase flow in single microfluidic channels through site-selective channel coating

    NARCIS (Netherlands)

    Logtenberg, Hella; Lopez-Martinez, Maria J.; Feringa, Ben L.; Browne, Wesley R.; Verpoorte, Elisabeth

    2011-01-01

    An approach to control two-phase flow systems in a poly(dimethylsiloxane) (PDMS) microfluidic device using spatially selective surface modification is demonstrated. Side-by-side flows of ethanol : water solutions containing different polymers are used to selectively modify both sides of a channel by

  15. Frequency Selective Surfaces for extended Bandwidth backing reflector functions

    NARCIS (Netherlands)

    Pasian, M.; Neto, A.; Monni, S.; Ettorre, M.; Gerini, G.

    2008-01-01

    This paper deals with the use of Frequency Selective Surfaces (FSS) to increase the Efficiency × Bandwidth product in Ultra-Wide Band (UWB) antenna arrays whose efficiency is limited by the front-to-back ratio. If the backing reflector is realized in one metal plane solution its location will be

  16. A time domain frequency-selective multivariate Granger causality approach.

    Science.gov (United States)

    Leistritz, Lutz; Witte, Herbert

    2016-08-01

    The investigation of effective connectivity is one of the major topics in computational neuroscience to understand the interaction between spatially distributed neuronal units of the brain. Thus, a wide variety of methods has been developed during the last decades to investigate functional and effective connectivity in multivariate systems. Their spectrum ranges from model-based to model-free approaches with a clear separation into time and frequency range methods. We present in this simulation study a novel time domain approach based on Granger's principle of predictability, which allows frequency-selective considerations of directed interactions. It is based on a comparison of prediction errors of multivariate autoregressive models fitted to systematically modified time series. These modifications are based on signal decompositions, which enable a targeted cancellation of specific signal components with specific spectral properties. Depending on the embedded signal decomposition method, a frequency-selective or data-driven signal-adaptive Granger Causality Index may be derived.

  17. Multiple flow profiles for two-phase flow in single microfluidic channels through site-selective channel coating.

    Science.gov (United States)

    Logtenberg, Hella; Lopez-Martinez, Maria J; Feringa, Ben L; Browne, Wesley R; Verpoorte, Elisabeth

    2011-06-21

    An approach to control two-phase flow systems in a poly(dimethylsiloxane) (PDMS) microfluidic device using spatially selective surface modification is demonstrated. Side-by-side flows of ethanol : water solutions containing different polymers are used to selectively modify both sides of a channel by laminar flow patterning. Introduction of air pockets during modification allows for control over the length of the channel section that is modified. This approach makes it possible to achieve slug flow and side-by-side flow of water : 1-octanol simultaneously within the same PDMS channel, without the need of additional structural elements. A key finding is that conditioning of the PDMS channels with 1-octanol before polymer deposition is crucial to achieving stable side-by-side flows.

  18. Low-Bandwidth Channel Quality Indication for OFDMA Frequency Domain Packet Scheduling

    DEFF Research Database (Denmark)

    Kolding, Troels E.; Frederiksen, Frank; Pokhariyal, Akhilesh

    2007-01-01

     In this paper, we study methods for lowering the bandwidth needed for the UE to transmit channel quality indication (CQI) for time and frequency domain scheduling (FDPS) in OFDMA. We consider smart compression methods, such as threshold based indication, to only include scheduler-relevant inform...... In this paper, we study methods for lowering the bandwidth needed for the UE to transmit channel quality indication (CQI) for time and frequency domain scheduling (FDPS) in OFDMA. We consider smart compression methods, such as threshold based indication, to only include scheduler......-relevant information in the CQI. We find that a 60-70% CQI bandwidth reduction is possible with less than 5-10% impact on scheduling performance. Further, we consider the impact of lowering the CQI reporting rate on both mobility performance and increased measuring accuracy due to longer averaging interval. We find...

  19. Frequency Selection for Multi-frequency Acoustic Measurement of Suspended Sediment

    Science.gov (United States)

    Chen, X.; HO, H.; Fu, X.

    2017-12-01

    Multi-frequency acoustic measurement of suspended sediment has found successful applications in marine and fluvial environments. Difficult challenges remain in regard to improving its effectiveness and efficiency when applied to high concentrations and wide size distributions in rivers. We performed a multi-frequency acoustic scattering experiment in a cylindrical tank with a suspension of natural sands. The sands range from 50 to 600 μm in diameter with a lognormal size distribution. The bulk concentration of suspended sediment varied from 1.0 to 12.0 g/L. We found that the commonly used linear relationship between the intensity of acoustic backscatter and suspended sediment concentration holds only at sufficiently low concentrations, for instance below 3.0 g/L. It fails at a critical value of concentration that depends on measurement frequency and the distance between the transducer and the target point. Instead, an exponential relationship was found to work satisfactorily throughout the entire range of concentration. The coefficient and exponent of the exponential function changed, however, with the measuring frequency and distance. Considering the increased complexity of inverting the concentration values when an exponential relationship prevails, we further analyzed the relationship between measurement error and measuring frequency. It was also found that the inversion error may be effectively controlled within 5% if the frequency is properly set. Compared with concentration, grain size was found to heavily affect the selection of optimum frequency. A regression relationship for optimum frequency versus grain size was developed based on the experimental results.

  20. The influence of environmental parameters on the optimal frequency in a shallow underwater acoustic channel

    Science.gov (United States)

    Zarnescu, George

    2015-02-01

    In a shallow underwater acoustic channel the delayed replicas of a transmitted signal are mainly due to the interactions with the sea surface and the bottom layer. If a specific underwater region on the globe is considered, for which the sedimentary layer structure is constant across the transmission distance, then the variability of the amplitude-delay profile is determined by daily and seasonal changes of the sound speed profile (SSP) and by weather changes, such as variations of the wind speed. Such a parameter will influence the attenuation at the surface, the noise level and the profile of the sea surface. The temporal variation of the impulse response in a shallow underwater acoustic channel determines the variability of the optimal transmission frequency. If the ways in which the optimal frequency changes can be predicted, then an adaptive analog transceiver can be easily designed for an underwater acoustic modem or it can be found when a communication link has high throughput. In this article it will be highlighted the way in which the amplitude-delay profile is affected by the sound speed profile, wind speed and channel depth and also will be emphasized the changes of the optimal transmission frequency in a configuration, where the transmitter and receiver are placed on the seafloor and the bathymetry profile will be considered flat, having a given composition.

  1. Learning natural selection from the site frequency spectrum.

    Science.gov (United States)

    Ronen, Roy; Udpa, Nitin; Halperin, Eran; Bafna, Vineet

    2013-09-01

    Genetic adaptation to external stimuli occurs through the combined action of mutation and selection. A central problem in genetics is to identify loci responsive to specific selective constraints. Many tests have been proposed to identify the genomic signatures of natural selection by quantifying the skew in the site frequency spectrum (SFS) under selection relative to neutrality. We build upon recent work that connects many of these tests under a common framework, by describing how selective sweeps affect the scaled SFS. We show that the specific skew depends on many attributes of the sweep, including the selection coefficient and the time under selection. Using supervised learning on extensive simulated data, we characterize the features of the scaled SFS that best separate different types of selective sweeps from neutrality. We develop a test, SFselect, that consistently outperforms many existing tests over a wide range of selective sweeps. We apply SFselect to polymorphism data from a laboratory evolution experiment of Drosophila melanogaster adapted to hypoxia and identify loci that strengthen the role of the Notch pathway in hypoxia tolerance, but were missed by previous approaches. We further apply our test to human data and identify regions that are in agreement with earlier studies, as well as many novel regions.

  2. Optically transparent frequency selective surfaces on flexible thin plastic substrates

    Directory of Open Access Journals (Sweden)

    Aliya A. Dewani

    2015-02-01

    Full Text Available A novel 2D simple low cost frequency selective surface was screen printed on thin (0.21 mm, flexible transparent plastic substrate (relative permittivity 3.2. It was designed, fabricated and tested in the frequency range 10-20 GHz. The plane wave transmission and reflection coefficients agreed with numerical modelling. The effective permittivity and thickness of the backing sheet has a significant effect on the frequency characteristics. The stop band frequency reduced from 15GHz (no backing to 12.5GHz with polycarbonate. The plastic substrate thickness beyond 1.8mm has minimal effect on the resonant frequency. While the inner element spacing controls the stop-band frequency, the substrate thickness controls the bandwidth. The screen printing technique provided a simple, low cost FSS fabrication method to produce flexible, conformal, optically transparent and bio-degradable FSS structures which can find their use in electromagnetic shielding and filtering applications in radomes, reflector antennas, beam splitters and polarizers.

  3. Gating the Selectivity Filter in ClC Chloride Channels

    Science.gov (United States)

    Dutzler, Raimund; Campbell, Ernest B.; MacKinnon, Roderick

    2003-04-01

    ClC channels conduct chloride (Cl-) ions across cell membranes and thereby govern the electrical activity of muscle cells and certain neurons, the transport of fluid and electrolytes across epithelia, and the acidification of intracellular vesicles. The structural basis of ClC channel gating was studied. Crystal structures of wild-type and mutant Escherichia coli ClC channels bound to a monoclonal Fab fragment reveal three Cl- binding sites within the 15-angstrom neck of an hourglass-shaped pore. The Cl- binding site nearest the extracellular solution can be occupied either by a Cl- ion or by a glutamate carboxyl group. Mutations of this glutamate residue in Torpedo ray ClC channels alter gating in electrophysiological assays. These findings reveal a form of gating in which the glutamate carboxyl group closes the pore by mimicking a Cl- ion.

  4. Mechanical stress-controlled tunable active frequency-selective surface

    Science.gov (United States)

    Huang, Bo-Cin; Hong, Jian-Wei; Lo, Cheng-Yao

    2017-01-01

    This study proposes a tunable active frequency-selective surface (AFSS) realized by mechanically expanding or contracting a split-ring resonator (SRR) array. The proposed AFSS transfers mechanical stress from its elastic substrate to the top of the SRR, thereby achieving electromagnetic (EM) modulation without the need for an additional external power supply, meeting the requirements for the target application: the invisibility cloak. The operating mechanism of the proposed AFSS differs from those of other AFSSs, supporting modulations in arbitrary frequencies in the target range. The proposed stress-controlled or strain-induced EM modulation proves the existence of an identical and linear relationship between the strain gradient and the frequency shift, implying its suitability for other EM modulation ranges and applications.

  5. Selection of the wavelet function for the frequencies estimation

    International Nuclear Information System (INIS)

    Garcia R, A.

    2007-01-01

    At the moment the signals are used to diagnose the state of the systems, by means of the extraction of their more important characteristics such as the frequencies, tendencies, changes and temporary evolutions. This characteristics are detected by means of diverse analysis techniques, as Autoregressive methods, Fourier Transformation, Fourier transformation in short time, Wavelet transformation, among others. The present work uses the one Wavelet transformation because it allows to analyze stationary, quasi-stationary and transitory signals in the time-frequency plane. It also describes a methodology to select the scales and the Wavelet function to be applied the one Wavelet transformation with the objective of detecting to the dominant system frequencies. (Author)

  6. ERPWAVELAB a toolbox for multi-channel analysis of time-frequency transformed event related potentials.

    Science.gov (United States)

    Mørup, Morten; Hansen, Lars Kai; Arnfred, Sidse M

    2007-04-15

    The open source toolbox 'ERPWAVELAB' is developed for multi-channel time-frequency analysis of event related activity of EEG and MEG data. The toolbox provides tools for data analysis and visualization of the most commonly used measures of time-frequency transformed event related data as well as data decomposition through non-negative matrix and multi-way (tensor) factorization. The decompositions provided can accommodate additional dimensions like subjects, conditions or repeats and as such they are perfected for group analysis. Furthermore, the toolbox enables tracking of phase locked activity from one channel-time-frequency instance to another as well as tools for artifact rejection in the time-frequency domain. Several other features are highlighted. ERPWAVELAB can freely be downloaded from www.erpwavelab.org, requires EEGLAB [Delorme A, Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Meth 2004;134:9-21] and runs under MATLAB (The Mathworks, Inc.).

  7. Tuning Mechanisms in a Corrugated Origami Frequency Selective Surface (Preprint)

    Science.gov (United States)

    2017-07-09

    AFRL-RX-WP-JA-2017-0298 TUNING MECHANISMS IN A CORRUGATED ORIGAMI FREQUENCY SELECTIVE SURFACE (PREPRINT) Kazuko Fuchi UDRI... SURFACE (PREPRINT) 5a. CONTRACT NUMBER FA8650-15-D-5405-0002 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 1) Kazuko Fuchi...Clearance Date: 12 Jan 2017. This document contains color. The U.S. Government is joint author of the work and has the right to use, modify, reproduce

  8. Channel selection for simultaneous and proportional myoelectric prosthesis control of multiple degrees-of-freedom

    Science.gov (United States)

    Hwang, Han-Jeong; Hahne, Janne Mathias; Müller, Klaus-Robert

    2014-10-01

    Objective. Recent studies have shown the possibility of simultaneous and proportional control of electrically powered upper-limb prostheses, but there has been little investigation on optimal channel selection. The objective of this study is to find a robust channel selection method and the channel subsets most suitable for simultaneous and proportional myoelectric prosthesis control of multiple degrees-of-freedom (DoFs). Approach. Ten able-bodied subjects and one person with congenital upper-limb deficiency took part in this study, and performed wrist movements with various combinations of two DoFs (flexion/extension and radial/ulnar deviation). During the experiment, high density electromyographic (EMG) signals and the actual wrist angles were recorded with an 8 × 24 electrode array and a motion tracking system, respectively. The wrist angles were estimated from EMG features with ridge regression using the subsets of channels chosen by three different channel selection methods: (1) least absolute shrinkage and selection operator (LASSO), (2) sequential feature selection (SFS), and (3) uniform selection (UNI). Main results. SFS generally showed higher estimation accuracy than LASSO and UNI, but LASSO always outperformed SFS in terms of robustness, such as noise addition, channel shift and training data reduction. It was also confirmed that about 95% of the original performance obtained using all channels can be retained with only 12 bipolar channels individually selected by LASSO and SFS. Significance. From the analysis results, it can be concluded that LASSO is a promising channel selection method for accurate simultaneous and proportional prosthesis control. We expect that our results will provide a useful guideline to select optimal channel subsets when developing clinical myoelectric prosthesis control systems based on continuous movements with multiple DoFs.

  9. Sapphire decelerating capillary channel integrated with antenna at frequency 0.675 THz

    Science.gov (United States)

    Ashanin, I. A.; Polozov, S. M.

    2016-07-01

    In recent years, there has been an increasing interest in THz-radiation for application in medicine (THz tomographs), in pharmaceutics (composition analysis for medicines), in introscopy of large-scale objects (ships, trains, containers) and others. THz-radiation can be generated by relativistic electron bunches passing through the Cherenkov decelerating capillary channel (circular waveguide with dielectric filling) with horn extraction. Relativistic electron beams having ∼100 µm in diameter and pulse durations of 1 ps or less (as in photoinjectors) are capable of producing substantial power of THz-radiation. High-peak power coherent Cherenkov radiation can be produced by a properly modulated high-brightness electron beam or by a single, high-density bunch having sub-wavelength dimension. The aperture of a Cherenkov decelerating structure should be comparable with the mm or sub-mm wavelength (0.1-3 mm). Different dielectric materials for the internal surface coating of the capillary channel of mm-sub-mm cross-section can be used. As is known, a frequency of 0.675 THz corresponds to the atmospheric window with high transparency. This report presents the results of electrodynamics study of the metallized sapphire decelerating Cherenkov capillary. A horn antenna attached to the metallized sapphire capillary channel at the 0.675 THz resonant frequency will be considered.

  10. A Portable MIMO Testbed and Selected Channel Measurements

    Directory of Open Access Journals (Sweden)

    Goud Jr Paul

    2006-01-01

    Full Text Available A portable multiple-input multiple-output (MIMO testbed that is based on field programmable gate arrays (FPGAs and which operates in the 902–928 MHz industrial, scientific, and medical (ISM band has been developed by the High Capacity Digital Communications (HCDC Laboratory at the University of Alberta. We present a description of the HCDC testbed along with MIMO channel capacities that were derived from measurements taken with the HCDC testbed for three special locations: a narrow corridor, an athletics field that is surrounded by a metal fence, and a parkade. These locations are special because the channel capacities are different from what is expected for a typical indoor or outdoor channel. For two of the cases, a ray-tracing analysis has been performed and the simulated channel capacity values closely match the values calculated from the measured data. A ray-tracing analysis, however, requires accurate geometrical measurements and sophisticated modeling for each specific location. A MIMO testbed is ideal for quickly obtaining accurate channel capacity information.

  11. MR imaging of osteonecrosis using frequency selective chemical shift sequences

    International Nuclear Information System (INIS)

    Duda, S.H.; Laniado, M.; Schick, F.

    1993-01-01

    The MR appearance of osteonecrosis was assessed on selective fat- and water images to further evaluate the nature of double-line sign. Conventional T1- and T2-weighted SE and frequency selective chemical shift images of eight patients with avascular necrosis of the femoral head and three patients with bone infarcts were retrospectively reviewed. Eight of 11 patients showed a double-line sign on T2-weighted SE images. In these cases, correlation with selective water images revealed that a chemical shift artifact contributed to appearance and location of the hyperintense line. The authors conclude that chemical shift imaging improves our understanding of the nature of the double-line sign. (orig.) [de

  12. Dual Channel S-Band Frequency Modulated Continuous Wave Through-Wall Radar Imaging

    Directory of Open Access Journals (Sweden)

    Ying-Chun Li

    2018-01-01

    Full Text Available This article deals with the development of a dual channel S-Band frequency-modulated continuous wave (FMCW system for a through-the-wall imaging (TWRI system. Most existing TWRI systems using FMCW were developed for synthetic aperture radar (SAR which has many drawbacks such as the need for several antenna elements and movement of the system. Our implemented TWRI system comprises a transmitting antenna and two receiving antennas, resulting in a significant reduction of the number of antenna elements. Moreover, a proposed algorithm for range-angle-Doppler 3D estimation based on a 3D shift invariant structure is utilized in our implemented dual channel S-band FMCW TWRI system. Indoor and outdoor experiments were conducted to image the scene beyond a wall for water targets and person targets, respectively. The experimental results demonstrate that high-quality imaging can be achieved under both experimental scenarios.

  13. Frequency selective bolometer development at Argonne National Laboratory

    Science.gov (United States)

    Datesman, Aaron; Pearson, John; Wang, Gensheng; Yefremenko, Volodymyr; Divan, Ralu; Downes, Thomas; Chang, Clarence; McMahon, Jeff; Meyer, Stephan; Carlstrom, John; Logan, Daniel; Perera, Thushara; Wilson, Grant; Novosad, Valentyn

    2008-07-01

    We discuss the development, at Argonne National Laboratory, of a four-pixel camera suitable for photometry of distant dusty galaxies located by Spitzer and SCUBA, and for study of other millimeter-wave sources such as ultra-luminous infrared galaxies, the Sunyaev-Zeldovich (SZ) effect in clusters, and galactic dust. Utilizing Frequency Selective Bolometers (FSBs) with superconducting Transition-Edge Sensors (TESs), each of the camera's four pixels is sensitive to four colors, with frequency bands centered approximately at 150, 220, 270, and 360 GHz. The current generation of these devices utilizes proximity effect superconducting bilayers of Mo/Au or Ti/Au for TESs, along with frequency selective circuitry on membranes of silicon nitride 1 cm across and 1 micron thick. The operational properties of these devices are determined by this circuitry, along with thermal control structures etched into the membranes. These etched structures do not perforate the membrane, so that the device is both comparatively robust mechanically and carefully tailored in terms of its thermal transport properties. In this paper, we report on development of the superconducting bilayer TES technology and characterization of the FSB stacks. This includes the use of new materials, the design and testing of thermal control structures, the introduction of desirable thermal properties using buried layers of crystalline silicon underneath the membrane, detector stability control, and optical and thermal test results. The scientific motivation, FSB design, FSB fabrication, and measurement results are discussed.

  14. Achieving pattern uniformity in plasmonic lithography by spatial frequency selection

    Science.gov (United States)

    Liang, Gaofeng; Chen, Xi; Zhao, Qing; Guo, L. Jay

    2018-01-01

    The effects of the surface roughness of thin films and defects on photomasks are investigated in two representative plasmonic lithography systems: thin silver film-based superlens and multilayer-based hyperbolic metamaterial (HMM). Superlens can replicate arbitrary patterns because of its broad evanescent wave passband, which also makes it inherently vulnerable to the roughness of the thin film and imperfections of the mask. On the other hand, the HMM system has spatial frequency filtering characteristics and its pattern formation is based on interference, producing uniform and stable periodic patterns. In this work, we show that the HMM system is more immune to such imperfections due to its function of spatial frequency selection. The analyses are further verified by an interference lithography system incorporating the photoresist layer as an optical waveguide to improve the aspect ratio of the pattern. It is concluded that a system capable of spatial frequency selection is a powerful method to produce deep-subwavelength periodic patterns with high degree of uniformity and fidelity.

  15. Comparison of ionic selectivity of batrachotoxin-activated channels with different tetrodotoxin dissociation constants.

    Science.gov (United States)

    Huang, L Y; Catterall, W A; Ehrenstein, G

    1979-06-01

    The purpose of these experiments is to test whether the differences between normal and tetrodotoxin-resistant Na+ channels reside in the selectivity filter. To do this, we have compared the selectivity of batrachotoxin-activated channels for alkali cations, organic cations, and nonelectrolytes in two neuroblastoma clonal cell lines: N18, which has normal tetrodotoxin (TTX) sensitivity, and C9, which is relatively TTX-resistant. We have also studied the effect of H+ on Na+ permeability and on the interaction between TTX and its receptor site in both cell lines. There is no qualitative difference between the two cell lines in any of these properties. In both cell lines the batrachotoxin-activated Na+ channels have a selectivity sequence of Tl+ greater than Na+ greater than K+, guanidinium greater than Rb+ greater than Cs+, methylamine. Also, in both cell lines H+ blocks Na+ channels with a pKa of 5.5 and inhibits the action of TTX with the same pKa. These observations indicate that the selectivity filters of the Na+ channels in C9 and N18 do not differ significantly despite the 100-fold difference in TTX-affinity. Our selectivity studies of batrachotoxin-activated Na+ channels for both cell lines suggest that these toxin-activated Na+ channels have a limiting pore size of 3.8 x 6.0 A, as compared to a pore size of 3.0 x 5.0 A for potential-activated Na+ channels.

  16. Wavelength-selective fluorescence in ion channels formed by ...

    Indian Academy of Sciences (India)

    TECS

    channel. 5. An important aspect of this conformation is the membrane interfacial location of the tryptophan residues, a common feature of many transmembrane helices. 6–8. Gramicidins are linear pentadecapeptide antibio- tics with a molecular weight of ~1900. They are pro- duced by the soil bacterium Bacillus brevis, and.

  17. Graphene-Based Sandwich Structures for Frequency Selectable Electromagnetic Shielding.

    Science.gov (United States)

    Song, Wei-Li; Gong, Congcheng; Li, Huimin; Cheng, Xiao-Dong; Chen, Mingji; Yuan, Xujin; Chen, Haosen; Yang, Yazheng; Fang, Daining

    2017-10-18

    Due to substantial development of electronics and telecommunication techniques, materials with electromagnetic interference (EMI) shielding performance are significant in alleviating the interference impacts induced from a remarkable variety of devices. In the work, we propose novel sandwich structures for manipulating the EM wave transport, which holds unique EMI shielding features of frequency selectivity. By employing electrical and magnetic loss spacers, the resultant sandwich structures are endowed with tunable EMI shielding performance, showing substantial improvements in overall shielding effectiveness along with pronounced shielding peak shift. The mechanisms suggest that the multiple interfaces, electromagnetic loss media, and changes of representative EM wavelength could be critical roles in tailoring the EMI shielding performance. The results provide a versatile strategy that could be extended in other frequency ranges and various types of sandwich structures, promising great opportunities for designing and fabricating advanced electromagnetic attenuation materials and devices.

  18. A novel broadband bi-mode active frequency selective surface

    Science.gov (United States)

    Xu, Yang; Gao, Jinsong; Xu, Nianxi; Shan, Dongzhi; Song, Naitao

    2017-05-01

    A novel broadband bi-mode active frequency selective surface (AFSS) is presented in this paper. The proposed structure is composed of a periodic array of convoluted square patches and Jerusalem Crosses. According to simulation results, the frequency response of AFSS definitely exhibits a mode switch feature between band-pass and band-stop modes when the diodes stay in ON and OFF states. In order to apply a uniform bias to each PIN diode, an ingenious biasing network based on the extension of Wheatstone bridge is adopted in prototype AFSS. The test results are in good agreement with the simulation results. A further physical mechanism of the bi-mode AFSS is shown by contrasting the distribution of electric field on the AFSS patterns for the two working states.

  19. A novel broadband bi-mode active frequency selective surface

    Directory of Open Access Journals (Sweden)

    Yang Xu

    2017-05-01

    Full Text Available A novel broadband bi-mode active frequency selective surface (AFSS is presented in this paper. The proposed structure is composed of a periodic array of convoluted square patches and Jerusalem Crosses. According to simulation results, the frequency response of AFSS definitely exhibits a mode switch feature between band-pass and band-stop modes when the diodes stay in ON and OFF states. In order to apply a uniform bias to each PIN diode, an ingenious biasing network based on the extension of Wheatstone bridge is adopted in prototype AFSS. The test results are in good agreement with the simulation results. A further physical mechanism of the bi-mode AFSS is shown by contrasting the distribution of electric field on the AFSS patterns for the two working states.

  20. A perspective on single-channel frequency-domain speech enhancement

    CERN Document Server

    Benesty, Jacob

    2010-01-01

    This book focuses on a class of single-channel noise reduction methods that are performed in the frequency domain via the short-time Fourier transform (STFT). The simplicity and relative effectiveness of this class of approaches make them the dominant choice in practical systems. Even though many popular algorithms have been proposed through more than four decades of continuous research, there are a number of critical areas where our understanding and capabilities still remain quite rudimentary, especially with respect to the relationship between noise reduction and speech distortion. All exis

  1. Frequency Characteristics of Path Loss and Delay-Angular Profile of Propagation Channels in An Indoor Room Environment in SHF Bands

    DEFF Research Database (Denmark)

    HANPINITSAK, Panawit; SAITO, Kentaro; Fan, Wei

    2017-01-01

    Comparison of channel characteristics at many frequency bands is necessary to study the frequency-de-pendency which is important for consistent multi-frequency spatial-temporal channel model. Path loss (PL) and power spectrum characteristics of the channel measured in a typical classroom line-of-sight...

  2. Divalent Metal Ion Transport across Large Biological Ion Channels and Their Effect on Conductance and Selectivity

    Directory of Open Access Journals (Sweden)

    Elena García-Giménez

    2012-01-01

    Full Text Available Electrophysiological characterization of large protein channels, usually displaying multi-ionic transport and weak ion selectivity, is commonly performed at physiological conditions (moderate gradients of KCl solutions at decimolar concentrations buffered at neutral pH. We extend here the characterization of the OmpF porin, a wide channel of the outer membrane of E. coli, by studying the effect of salts of divalent cations on the transport properties of the channel. The regulation of divalent cations concentration is essential in cell metabolism and understanding their effects is of key importance, not only in the channels specifically designed to control their passage but also in other multiionic channels. In particular, in porin channels like OmpF, divalent cations modulate the efficiency of molecules having antimicrobial activity. Taking advantage of the fact that the OmpF channel atomic structure has been resolved both in water and in MgCl2 aqueous solutions, we analyze the single channel conductance and the channel selectivity inversion aiming to separate the role of the electrolyte itself, and the counterion accumulation induced by the protein channel charges and other factors (binding, steric effects, etc. that being of minor importance in salts of monovalent cations become crucial in the case of divalent cations.

  3. A selectivity filter at the intracellular end of the acid-sensing ion channel pore

    DEFF Research Database (Denmark)

    Lynagh, Timothy; Flood, Emelie; Boiteux, Céline

    2017-01-01

    Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in the channel pore, but experimental verification...

  4. Broadband Reflectionless Metasheets: Frequency-Selective Transmission and Perfect Absorption

    Directory of Open Access Journals (Sweden)

    V. S. Asadchy

    2015-07-01

    Full Text Available Energy of propagating electromagnetic waves can be fully absorbed in a thin lossy layer, but only in a narrow frequency band, as follows from the causality principle. On the other hand, it appears that there are no fundamental limitations on broadband matching of thin resonant absorbing layers. However, known thin absorbers produce significant reflections outside of the resonant absorption band. In this paper, we explore possibilities to realize a thin absorbing layer that produces no reflected waves in a very wide frequency range, while the transmission coefficient has a narrow peak of full absorption. Here we show, both theoretically and experimentally, that a thin resonant absorber, invisible in reflection in a very wide frequency range, can be realized if one and the same resonant mode of the absorbing array unit cells is utilized to create both electric and magnetic responses. We test this concept using chiral particles in each unit cell, arranged in a periodic planar racemic array, utilizing chirality coupling in each unit cell but compensating the field coupling at the macroscopic level. We prove that the concept and the proposed realization approach also can be used to create nonreflecting layers for full control of transmitted fields. Our results can have a broad range of potential applications over the entire electromagnetic spectrum including, for example, perfect ultracompact wave filters and selective multifrequency sensors.

  5. Characterization of a C-type natriuretic peptide (CNP-39)-formed cation-selective channel from platypus (Ornithorhynchus anatinus) venom

    Science.gov (United States)

    Kourie, Joseph I

    1999-01-01

    The lipid bilayer technique is used to characterize the biophysical and pharmacological properties of a novel, fast, cation-selective channel formed by incorporating platypus (Ornithorhynchus anatinus) venom (OaV) into lipid membranes.A synthetic C-type natriuretic peptide OaCNP-39, which is identical to that present in platypus venom, mimics the conductance, kinetics, selectivity and pharmacological properties of the OaV-formed fast cation-selective channel. The N-terminal fragment containing residues 1-17, i.e. OaCNP-39(1-17), induces the channel activity.The current amplitude of the TEACl-insensitive fast cation-selective channel is dependent on cytoplasmic K+, [K+]cis. The increase in the current amplitude, as a function of increasing [K+]cis, is non-linear and can be described by the Michaelis-Menten equation. At +140 mV, the values of γmax and KS are 63·1 pS and 169 mM, respectively, whereas at 0 mV the values of γmax and KS are 21·1 pS and 307 mM, respectively. γmax and KS are maximal single channel conductance and concentration for half-maximal γ, respectively. The calculated permeability ratios, PK:PRb:PNa: PCs:PLi, were 1:0·76:0·21:0·09:0·03, respectively.The probability of the fast channel being open, Po, increases from 0·15 at 0 mV to 0·75 at +140 mV. In contrast, the channel frequency, Fo, decreases from 400 to 180 events per second for voltages between 0 mV and +140. The mean open time, To, increases as the bilayer is made more positive, between 0 and +140 mV. The mean values of the voltage-dependent kinetic parameters, Po, Fo, To and mean closed time (Tc), are independent of [KCl]cis between 50 and 750 mM (P > 0·05).It is proposed that some of the symptoms of envenomation by platypus venom may be caused partly by changes in cellular functions mediated via the OaCNP-39-formed fast cation-selective channel, which affects signal transduction. PMID:10381585

  6. Multiscale bloom dynamics from a high frequency autonomous measurement system in the Eastern English Channel

    Science.gov (United States)

    Derot, Jonathan; Schmitt, François; Gentilhomme, Valérie

    2014-05-01

    We consider here a dataset from an Eulerian automated system, located on the coastal area of the French side of the English Channel (Boulogne-sur-Mer), called MAREL Carnot, operated by IFREMER (France). This system records more than 15 physico-chemical parameters at 20 minutes intervals, and at the constant depth of -1,5m whatever the tidal range. Our study focuses on the period 2004 to 2011. The objective of this study is to have a better understanding of the bloom fluorescence multiscale dynamics, as regards the coastal area of English Channel and possible influence of temperature on this dynamics. Annual blooms are visible, superposed to multiscale fluctuations. The probability density function (PDF) of the fluorescence time series very nicely obeys a power law with slope -2. The PDF for annual portions obeys also power laws, with slopes which are related to the annual average. Empirical mode decomposition (EMD) is used to study the dynamics and display the power spectrum, which will be linked with these dynamics. EMD method is also used to extract a trend and isolate the blooms from the high frequency dynamics. We show that the high frequency part of the fluorescence dynamics has a very large variance during bloom events, compared to normal conditions. We also show that there is a link between the mean winter temperature and the strength of bloom next spring. These results contribute to statistically characterize the bloom dynamics and extract some possible universal relations. Keywords: English Channel; Autonomous monitoring; Power spectra; EMD method; Probability density functions; Power laws.

  7. New selection criteria for channel refueling of a Candu-6 reactor: introduction to floppy rules

    International Nuclear Information System (INIS)

    Brissette, D.

    2001-01-01

    A revised set of rules is in use at Gentilly-2 NGS for the selection of channels for refuelling. Traditional hard channel rejection rules (of go/no-go type) have been replaced by a more efficient set of soft evaluation rules based on concepts borrowed to the Fuzzy Logic. New evaluation rules, labelled as 'Floppy Rules', enable to assess and rate the channel suitability for refuelling by using a smooth and natural continuum of values qualifying excellent, good, fair and poor choices. Global channel suitability for refuelling is measured by combining separate ratings obtained from individual evaluation rules. Each evaluation rule is based on a specific control parameter related to local or lumped core properties. Two new software codes (NEWRULES and REFUEL) designed around the concept of Floppy Rules enable to perform a very efficient selection of optimized channel refuelling sequences either in manual and automatic mode. (author)

  8. Joint duplex mode selection, channel allocation, and power control for full-duplex cognitive femtocell networks

    Directory of Open Access Journals (Sweden)

    Mingjie Feng

    2015-02-01

    Full Text Available In this paper, we aim to maximize the sum rate of a full-duplex cognitive femtocell network (FDCFN as well as guaranteeing the quality of service (QoS of users in the form of a required signal to interference plus noise ratios (SINR. We first consider the case of a pair of channels, and develop optimum-achieving power control solutions. Then, for the case of multiple channels, we formulate joint duplex model selection, power control, and channel allocation as a mixed integer nonlinear problem (MINLP, and propose an iterative framework to solve it. The proposed iterative framework consists of a duplex mode selection scheme, a near-optimal distributed power control algorithm, and a greedy channel allocation algorithm. We prove the convergence of the proposed iterative framework as well as a lower bound for the greedy channel allocation algorithm. Numerical results show that the proposed schemes effectively improve the sum rate of FDCFNs.

  9. Riparian vegetation patterns in relation to fluvial landforms and channel evolution along selected rivers of Tuscany (Central Italy)

    Science.gov (United States)

    Hupp, C.R.; Rinaldi, M.

    2007-01-01

    Riparian vegetation distribution patterns and diversity relative to various fluvial geomorphic channel patterns, landforms, and processes are described and interpreted for selected rivers of Tuscany, Central Italy; with emphasis on channel evolution following human impacts. Field surveys were conducted along thirteen gauged reaches for species presence, fluvial landforms, and the type and amount of channel/riparian zone change. Inundation frequency of different geomorphic surfaces was determined, and vegetation data were analyzed using BDA (binary discriminate analysis) and DCA (detrended correspondence analysis) and related to hydrogeomorphology. Multivariate analyses revealed distinct quantitative vegetation patterns relative to six major fluvial geomorphic surfaces. DCA of the vegetation data also showed distinct associations of plants to processes of adjustment that are related to stage of channel evolution, and clearly separated plants along disturbance/landform/soil moisture gradients. Species richness increases from the channel bed to the terrace and on heterogeneous riparian areas, whereas species richness decreases from moderate to intense incision and from low to intense narrowing. ?? 2007 by Association of American Geographers.

  10. Active feedback receiver with integrated tunable RF channel selectivity, distortion cancelling, 48dB stopband rejection and >+12dBm wideband IIP3, occupying

    NARCIS (Netherlands)

    Youssef, S.S.T.; van der Zee, Ronan A.R.; Nauta, Bram

    2012-01-01

    The impedance transformation property of passive mixers enables integrated high-Q channel selection at RF with a programmable center frequency through a clock [1,2]. As such, this technique is suitable for addressing both linearity and flexibility requirements in wideband and cognitive radio

  11. Selection of Inhibitor-Resistant Viral Potassium Channels Identifies a Selectivity Filter Site that Affects Barium and Amantadine Block

    Science.gov (United States)

    Fujiwara, Yuichiro; Arrigoni, Cristina; Domigan, Courtney; Ferrara, Giuseppina; Pantoja, Carlos; Thiel, Gerhard; Moroni, Anna; Minor, Daniel L.

    2009-01-01

    Background Understanding the interactions between ion channels and blockers remains an important goal that has implications for delineating the basic mechanisms of ion channel function and for the discovery and development of ion channel directed drugs. Methodology/Principal Findings We used genetic selection methods to probe the interaction of two ion channel blockers, barium and amantadine, with the miniature viral potassium channel Kcv. Selection for Kcv mutants that were resistant to either blocker identified a mutant bearing multiple changes that was resistant to both. Implementation of a PCR shuffling and backcrossing procedure uncovered that the blocker resistance could be attributed to a single change, T63S, at a position that is likely to form the binding site for the inner ion in the selectivity filter (site 4). A combination of electrophysiological and biochemical assays revealed a distinct difference in the ability of the mutant channel to interact with the blockers. Studies of the analogous mutation in the mammalian inward rectifier Kir2.1 show that the T→S mutation affects barium block as well as the stability of the conductive state. Comparison of the effects of similar barium resistant mutations in Kcv and Kir2.1 shows that neighboring amino acids in the Kcv selectivity filter affect blocker binding. Conclusions/Significance The data support the idea that permeant ions have an integral role in stabilizing potassium channel structure, suggest that both barium and amantadine act at a similar site, and demonstrate how genetic selections can be used to map blocker binding sites and reveal mechanistic features. PMID:19834614

  12. Dimensionality Reduction and Channel Selection of Motor Imagery Electroencephalographic Data

    OpenAIRE

    Naeem, Muhammad; Brunner, Clemens; Pfurtscheller, Gert

    2009-01-01

    The performance of spatial filters based on independent components analysis (ICA) was evaluated by employing principal component analysis (PCA) preprocessing for dimensional reduction. The PCA preprocessing was not found to be a suitable method that could retain motor imagery information in a smaller set of components. In contrast, 6 ICA components selected on the basis of visual inspection performed comparably (61.9%) to the full range of 22 components (63.9%). An automated selection of ICA ...

  13. Affects of spanwise heterogeneity and topographic height on Amplitude and Frequency modulation in channel flow turbulence

    Science.gov (United States)

    Awasthi, Ankit; Anderson, William

    2017-11-01

    We study the affects of spanwise heterogeneity on amplitude and frequency modulation of small-scale roughness-sublayer structures due to the passage of large-scale structures in the logarithmic region. Recent studies on amplitude and frequency modulation have prompted the development of a predictive model for near-wall dynamics. Such a model is of great interest to large-eddy simulation (LES), since near-wall processes are, by definition, never resolved. Here, we have used LES to model flows over a series of spanwise-heterogeneous topographies, where a domain with very long streamwise extent is used to ensure that very-large-scale motions are (or, can be) resolved. We report that the secondary flows globally disrupt the turbulence from channel physics, wherein the ``outer peak'' is either shifted to different wavelengths or nonexistent. This spectral density redistribution is assured to alter amplitude and frequency modulation rates within the roughness sublayer, and we present correlations of the small and large scales to demonstrate precisely that (following the wavelet decomposition, as outlined by). Thus, spanwise heterogeneity should be regarded as a model parameter in any rough-wall-generalized prognostic wall models. Air Force Office of Scientific Research, Grant # FA9550-14-1-0101.

  14. Frequency selective surfaces based high performance microstrip antenna

    CERN Document Server

    Narayan, Shiv; Jha, Rakesh Mohan

    2016-01-01

    This book focuses on performance enhancement of printed antennas using frequency selective surfaces (FSS) technology. The growing demand of stealth technology in strategic areas requires high-performance low-RCS (radar cross section) antennas. Such requirements may be accomplished by incorporating FSS into the antenna structure either in its ground plane or as the superstrate, due to the filter characteristics of FSS structure. In view of this, a novel approach based on FSS technology is presented in this book to enhance the performance of printed antennas including out-of-band structural RCS reduction. In this endeavor, the EM design of microstrip patch antennas (MPA) loaded with FSS-based (i) high impedance surface (HIS) ground plane, and (ii) the superstrates are discussed in detail. The EM analysis of proposed FSS-based antenna structures have been carried out using transmission line analogy, in combination with the reciprocity theorem. Further, various types of novel FSS structures are considered in desi...

  15. Mode Selection for a Single-Frequency Fiber Laser

    Science.gov (United States)

    Liu, Jian

    2010-01-01

    A superstructured fiber-grating-based mode selection filter for a single-frequency fiber laser eliminates all free-space components, and makes the laser truly all-fiber. A ring cavity provides for stable operations in both frequency and power. There is no alignment or realignment required. After the fibers and components are spliced together and packaged, there is no need for specially trained technicians for operation or maintenance. It can be integrated with other modules, such as telescope systems, without extra optical alignment due to the flexibility of the optical fiber. The filter features a narrow line width of 1 kHz and side mode suppression ratio of 65 dB. It provides a high-quality laser for lidar in terms of coherence length and signal-to-noise ratio, which is 20 dB higher than solid-state or microchip lasers. This concept is useful in material processing, medical equipment, biomedical instrumentation, and optical communications. The pulse-shaping fiber laser can be directly used in space, airborne, and satellite applications including lidar, remote sensing, illuminators, and phase-array antenna systems.

  16. The role of solvation in the binding selectivity of the L-type calcium channel.

    Science.gov (United States)

    Boda, Dezső; Henderson, Douglas; Gillespie, Dirk

    2013-08-07

    We present grand canonical Monte Carlo simulation results for a reduced model of the L-type calcium channel. While charged residues of the protein amino acids in the selectivity filter are treated explicitly, most of the degrees of freedom (including the rest of the protein and the solvent) are represented by their dielectric response, i.e., dielectric continua. The new aspect of this paper is that the dielectric coefficient in the channel is different from that in the baths. The ions entering the channel, thus, cross a dielectric boundary at the entrance of the channel. Simulating this case has been made possible by our recent methodological development [D. Boda, D. Henderson, B. Eisenberg, and D. Gillespie, J. Chem. Phys. 135, 064105 (2011)]. Our main focus is on the effect of solvation energy (represented by the Born energy) on monovalent vs. divalent ion selectivity in the channel. We find no significant change in selectivity by changing the dielectric coefficient in the channel because the larger solvation penalty is counterbalanced by the enhanced Coulomb attraction inside the channel as soon as we use the Born radii (fitted to experimental hydration energies) to compute the solvation penalty from the Born equation.

  17. Dimensionality Reduction and Channel Selection of Motor Imagery Electroencephalographic Data

    Directory of Open Access Journals (Sweden)

    Muhammad Naeem

    2009-01-01

    Full Text Available The performance of spatial filters based on independent components analysis (ICA was evaluated by employing principal component analysis (PCA preprocessing for dimensional reduction. The PCA preprocessing was not found to be a suitable method that could retain motor imagery information in a smaller set of components. In contrast, 6 ICA components selected on the basis of visual inspection performed comparably (61.9% to the full range of 22 components (63.9%. An automated selection of ICA components based on a variance criterion was also carried out. Only 8 components chosen this way performed better (63.1% than visually selected components. A similar analysis on the reduced set of electrodes over mid-central and centro-parietal regions of the brain revealed that common spatial patterns (CSPs and Infomax were able to detect motor imagery activity with a satisfactory accuracy.

  18. Dimensionality Reduction and Channel Selection of Motor Imagery Electroencephalographic Data

    Science.gov (United States)

    Naeem, Muhammad; Brunner, Clemens; Pfurtscheller, Gert

    2009-01-01

    The performance of spatial filters based on independent components analysis (ICA) was evaluated by employing principal component analysis (PCA) preprocessing for dimensional reduction. The PCA preprocessing was not found to be a suitable method that could retain motor imagery information in a smaller set of components. In contrast, 6 ICA components selected on the basis of visual inspection performed comparably (61.9%) to the full range of 22 components (63.9%). An automated selection of ICA components based on a variance criterion was also carried out. Only 8 components chosen this way performed better (63.1%) than visually selected components. A similar analysis on the reduced set of electrodes over mid-central and centro-parietal regions of the brain revealed that common spatial patterns (CSPs) and Infomax were able to detect motor imagery activity with a satisfactory accuracy. PMID:19536346

  19. Dimensionality reduction and channel selection of motor imagery electroencephalographic data.

    Science.gov (United States)

    Naeem, Muhammad; Brunner, Clemens; Pfurtscheller, Gert

    2009-01-01

    The performance of spatial filters based on independent components analysis (ICA) was evaluated by employing principal component analysis (PCA) preprocessing for dimensional reduction. The PCA preprocessing was not found to be a suitable method that could retain motor imagery information in a smaller set of components. In contrast, 6 ICA components selected on the basis of visual inspection performed comparably (61.9%) to the full range of 22 components (63.9%). An automated selection of ICA components based on a variance criterion was also carried out. Only 8 components chosen this way performed better (63.1%) than visually selected components. A similar analysis on the reduced set of electrodes over mid-central and centro-parietal regions of the brain revealed that common spatial patterns (CSPs) and Infomax were able to detect motor imagery activity with a satisfactory accuracy.

  20. Structural health monitoring and remote sensing of transportation infrastructure using embedded frequency selective surfaces.

    Science.gov (United States)

    2014-07-01

    The objective of this project was to investigate the use of Frequency Selective Surfaces (FSS) for structural health monitoring applications. Frequency Selective Surfaces (FSS) have long been used in the RF/microwave community to control scattering f...

  1. Channel selection in e-commerce age: A strategic analysis of co-op advertising models

    Directory of Open Access Journals (Sweden)

    Yongmei Liu

    2013-03-01

    Full Text Available Purpose: The purpose of this paper is to develop and compare two co-op advertising models: advertising model under traditional channel and co-op advertising model under dual channel, to select optimal channel structure to sell products for manufacturer and to derive optimal co-op advertising strategies for the manufacturer and the retailer.Design/methodology/approach: Stackelberg game theoretical is used to develop two co-op advertising models: co-op advertising model under traditional channel and co-op advertising model under dual channel. Then we compare the two models to select optimal channel structure to sell products for manufacturer and to derive optimal co-op advertising strategies for the manufacturer and the retailer. Furthermore, we analyze the impact of product web-fit on these optimal strategies and illustrate by some numeral examples. Based on our results, we provide some significant theories and managerial insights, and derive some probable paths of future research.Findings: We provide a framework for researching optimal co-op advertising strategies in a two-level supply chain considering different marketing channel structures. First, we discuss the traditional channel co-op adverting model and the dual channel co-op advertising model based on Stackelberg game theoretical, and we derive optimal co-op advertising strategies. Next, comparisons of these two channel structures are discussed and we find that the manufacturer always benefits from dual channel. But the retailer not always benefits from dual channel structure, and dual channel structure is better than retail channel with certain conditions. Also, the optimal co-op advertising strategies for the manufacturer and the retailer are obtained.Research limitations/implications: First, we focus on the aforementioned two channel structures; a further comparison with other channel structures can be investigated. Second, we ignore some factors that influence the demand of product

  2. KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels.

    Science.gov (United States)

    Zhang, Di; Thimmapaya, Rama; Zhang, Xu-Feng; Anderson, David J; Baranowski, John L; Scanio, Marc; Perez-Medrano, Arturo; Peddi, Sridhar; Wang, Zhi; Patel, Jyoti R; DeGoey, David A; Gopalakrishnan, Murali; Honore, Prisca; Yao, Betty B; Surowy, Carol S

    2011-08-30

    KCNQ2/3 voltage-gated potassium channels conduct low-threshold, slowly activating and non-inactivating currents to repolarize the neuronal resting membrane potential. The channels negatively regulate neuronal excitability and KCNQ2/3 openers are efficacious in hyperexcited states such as epilepsy and pain. We developed and utilized thallium influx assays to profile novel KCNQ2/3 channel openers with respect to selectivity across KCNQ subtypes and on requirement for tryptophan 236 of KCNQ2, a critical residue for activity of the KCNQ opener retigabine. Using distinct chemical series of openers, a quinazolinone series showed relatively poor selectivity across multiple KCNQ channels and lacked activity at the KCNQ2(W236L) mutant channel. In contrast, several novel benzimidazole openers showed selectivity for KCNQ2/3 and KCNQ2 and retain activity at KCNQ2(W236L). Profiling of several hundred KCNQ2/3 openers across multiple diverse chemical series revealed that openers show differential degrees of selectivity across subtypes, with selectivity most difficult to achieve against KCNQ2. In addition, we report the significant finding that KCNQ openers can pharmacologically differentiate between homomeric and heteromeric channels containing subtypes in common. Moreover, most openers assayed were dependent on the W236 for activity, whereas only a small number appear to use a distinct mechanism. Collectively, we provide novel insights into the molecular pharmacology of KCNQ channels by demonstrating differential selectivity and site of action for KCNQ2/3 openers. The high-throughput thallium influx assays should prove useful for rapid characterization of KCNQ openers and in guiding efforts to identify selective compounds for advancement towards the clinic. Copyright © 2011 Elsevier B.V. All rights reserved.

  3. The experimental program for high pressure gas filled radio frequency cavities for muon cooling channels

    Science.gov (United States)

    Freemire, B.; Chung, M.; Hanlet, P. M.; Johnson, R. P.; Moretti, A.; Torun, Y.; Yonehara, K.

    2018-01-01

    An intense beam of muons is needed to provide a luminosity on the order of 1034 cm‑2s‑1 for a multi-TeV collider. Because muons produced by colliding a multi-MW proton beam with a target made of carbon or mercury have a large phase space, significant six dimensional cooling is required. Through ionization cooling—the only cooling method that works within the lifetime of the muon—and emittance exchange, the desired emittances for a Higgs Factory or higher energy collider are attainable. A cooling channel utilizing gas filled radio frequency cavities has been designed to deliver the requisite cool muon beam. Technology development of these RF cavities has progressed from breakdown studies, through beam tests, to dielectric loaded and reentrant cavity designs. The results of these experiments are summarized.

  4. Frequency-dependent selection at rough expanding fronts

    Science.gov (United States)

    Kuhr, Jan-Timm; Stark, Holger

    2015-10-01

    Microbial colonies are experimental model systems for studying the colonization of new territory by biological species through range expansion. We study a generalization of the two-species Eden model, which incorporates local frequency-dependent selection, in order to analyze how social interactions between two species influence surface roughness of growing microbial colonies. The model includes several classical scenarios from game theory. We then concentrate on an expanding public goods game, where either cooperators or defectors take over the front depending on the system parameters. We analyze in detail the critical behavior of the nonequilibrium phase transition between global cooperation and defection and thereby identify a new universality class of phase transitions dealing with absorbing states. At the transition, the number of boundaries separating sectors decays with a novel power law in time and their superdiffusive motion crosses over from Eden scaling to a nearly ballistic regime. In parallel, the width of the front initially obeys Eden roughening and, at later times, passes over to selective roughening.

  5. Selectivity in Exposure to Information Channels during a Gubernatorial Election.

    Science.gov (United States)

    Edeani, David O.; Jacoubovitch, M. Daniel

    Data were collected from 93 journalism students before and after the 1978 Ohio gubernatorial election to determine how selectivity in exposure to information was influenced by information utility, fatalism (locus of control), past history of reinforcement, and political party identification. Results showed that past history of reinforcement and…

  6. Frequency-specific attentional modulation in human primary auditory cortex and midbrain

    NARCIS (Netherlands)

    Riecke, Lars; Peters, Judith C.; Valente, Giancarlo; Poser, Benedikt A.; Kemper, Valentin G.; Formisano, Elia; Sorger, Bettina

    Paying selective attention to an audio frequency selectively enhances activity within primary auditory cortex (PAC) at the tonotopic site (frequency channel) representing that frequency. Animal PAC neurons achieve this 'frequency-specific attentional spotlight' by adapting their frequency tuning,

  7. A Wearable Channel Selection-Based Brain-Computer Interface for Motor Imagery Detection.

    Science.gov (United States)

    Lo, Chi-Chun; Chien, Tsung-Yi; Chen, Yu-Chun; Tsai, Shang-Ho; Fang, Wai-Chi; Lin, Bor-Shyh

    2016-02-06

    Motor imagery-based brain-computer interface (BCI) is a communication interface between an external machine and the brain. Many kinds of spatial filters are used in BCIs to enhance the electroencephalography (EEG) features related to motor imagery. The approach of channel selection, developed to reserve meaningful EEG channels, is also an important technique for the development of BCIs. However, current BCI systems require a conventional EEG machine and EEG electrodes with conductive gel to acquire multi-channel EEG signals and then transmit these EEG signals to the back-end computer to perform the approach of channel selection. This reduces the convenience of use in daily life and increases the limitations of BCI applications. In order to improve the above issues, a novel wearable channel selection-based brain-computer interface is proposed. Here, retractable comb-shaped active dry electrodes are designed to measure the EEG signals on a hairy site, without conductive gel. By the design of analog CAR spatial filters and the firmware of EEG acquisition module, the function of spatial filters could be performed without any calculation, and channel selection could be performed in the front-end device to improve the practicability of detecting motor imagery in the wearable EEG device directly or in commercial mobile phones or tablets, which may have relatively low system specifications. Finally, the performance of the proposed BCI is investigated, and the experimental results show that the proposed system is a good wearable BCI system prototype.

  8. A Wearable Channel Selection-Based Brain-Computer Interface for Motor Imagery Detection

    Directory of Open Access Journals (Sweden)

    Chi-Chun Lo

    2016-02-01

    Full Text Available Motor imagery-based brain-computer interface (BCI is a communication interface between an external machine and the brain. Many kinds of spatial filters are used in BCIs to enhance the electroencephalography (EEG features related to motor imagery. The approach of channel selection, developed to reserve meaningful EEG channels, is also an important technique for the development of BCIs. However, current BCI systems require a conventional EEG machine and EEG electrodes with conductive gel to acquire multi-channel EEG signals and then transmit these EEG signals to the back-end computer to perform the approach of channel selection. This reduces the convenience of use in daily life and increases the limitations of BCI applications. In order to improve the above issues, a novel wearable channel selection-based brain-computer interface is proposed. Here, retractable comb-shaped active dry electrodes are designed to measure the EEG signals on a hairy site, without conductive gel. By the design of analog CAR spatial filters and the firmware of EEG acquisition module, the function of spatial filters could be performed without any calculation, and channel selection could be performed in the front-end device to improve the practicability of detecting motor imagery in the wearable EEG device directly or in commercial mobile phones or tablets, which may have relatively low system specifications. Finally, the performance of the proposed BCI is investigated, and the experimental results show that the proposed system is a good wearable BCI system prototype.

  9. Partial relay selection based on shadowing side information over generalized composite fading channels

    KAUST Repository

    Yilmaz, Ferkan

    2011-11-01

    In this paper, in contrast to the relay selection protocols available in the literature, we propose a partial relay selection protocol utilizing only the shadowing side information of the relays instead of their full channel side information in order to select a relay in a dual-hop relaying system through the available limited feedback channels and power budget. We then presented an exact unified performance expression combining the average bit error probability, ergodic capacity, and moments-generating function of the proposed partial relay selection over generalized fading channels. Referring to the unified performance expression introduced in [1], we explicitly offer a generic unified performance expression that can be easily calculated and that is applicable to a wide variety of fading scenarios. Finally, as an illustration of the mathematical formalism, some numerical and simulation results are generated for an extended generalized-K fading environment, and these numerical and simulation results are shown to be in perfect agreement. © 2011 IEEE.

  10. Overcharging below the nanoscale: Multivalent cations reverse the ion selectivity of a biological channel

    Science.gov (United States)

    García-Giménez, Elena; Alcaraz, Antonio; Aguilella, Vicente M.

    2010-02-01

    We report charge inversion within a nanoscopic biological protein ion channel in salts of multivalent ions. The presence of positive divalent and trivalent counterions reverses the cationic selectivity of the OmpF channel, a general diffusion porin located in the outer membrane of E. coli. We discuss the conditions under which charge inversion can be inferred from the change in sign of the measured quantity, the channel zero current potential. By comparing experimental results in protein channels whose charge has been modified after site-directed mutagenesis, the predictions of current theories of charge inversion are critically examined. It is emphasized that charge inversion does not necessarily increase with the bare surface charge density of the interface and that even this concept of surface charge density may become meaningless in some biological ion channels. Thus, any theory based on electrostatic correlations or chemical binding should explicitly take into account the particular structure of the charged interface.

  11. Frequency of V1016I and F1534C mutations in the voltage-gated sodium channel gene in Aedes aegypti in Venezuela.

    Science.gov (United States)

    Alvarez, Leslie C; Ponce, Gustavo; Saavedra-Rodriguez, Karla; Lopez, Beatriz; Flores, Adriana E

    2015-06-01

    The V1016I and F1534C mutations in the voltage-gated sodium channel gene have been associated with resistance to pyrethroids and DDT in Aedes aegypti mosquitoes. A study was carried out to determine the frequency of I1016 and C1534 by real-time PCR in five natural populations of Ae. aegypti in Venezuela during 2008, 2010 and 2012, as well as in a strain selected with 0.14 µg of deltamethrin for 15 generations. In natural populations, frequencies of I1016 varied between 0.01 and 0.37, and frequencies of C1534 between 0.35 and 1.0. In the Pampanito strain, the frequency of I1016 increased from 0.02 in F1 up to 0.5 in F15 and from 0.35 up to fixation for C1534 after selection with deltamethrin. The results showed that C1534 frequencies are higher than I1016 frequencies in natural populations of Ae. aegypti in Venezuela, and that deltamethrin selected the C1534 more rapidly than I1016. © 2014 Society of Chemical Industry.

  12. The non-selective monovalent cationic channels TRPM4 and TRPM5.

    Science.gov (United States)

    Guinamard, Romain; Sallé, Laurent; Simard, Christophe

    2011-01-01

    Transient Receptor Potential (TRP) proteins are non-selective cationic channels with a consistent Ca(2+)-permeability, except for TRPM4 and TRPM5 that are not permeable to this ion. However, Ca(2+) is a major regulator of their activity since both channels are activated by a rise in internal Ca(2+). Thus TRPM4 and TRPM5 are responsible for most of the Ca(2+)-activated non-selective cationic currents (NSC(Ca)) recorded in a large variety of tissues. Their activation induces cell-membrane depolarization that modifies the driving force for ions as well as activity of voltage gated channels and thereby strongly impacts cell physiology. In the last few years, the ubiquitously expressed TRPM4 channel has been implicated in insulin secretion, the immune response, constriction of cerebral arteries, the activity of inspiratory neurons and cardiac dysfunction. Conversely, TRPM5 whose expression is more restricted, has until now been mainly implicated in taste transduction.

  13. Optimal Channel Selection Based on Online Decision and Offline Learning in Multichannel Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Mu Qiao

    2017-01-01

    Full Text Available We propose a channel selection strategy with hybrid architecture, which combines the centralized method and the distributed method to alleviate the overhead of access point and at the same time provide more flexibility in network deployment. By this architecture, we make use of game theory and reinforcement learning to fulfill the optimal channel selection under different communication scenarios. Particularly, when the network can satisfy the requirements of energy and computational costs, the online decision algorithm based on noncooperative game can help each individual sensor node immediately select the optimal channel. Alternatively, when the network cannot satisfy the requirements of energy and computational costs, the offline learning algorithm based on reinforcement learning can help each individual sensor node to learn from its experience and iteratively adjust its behavior toward the expected target. Extensive simulation results validate the effectiveness of our proposal and also prove that higher system throughput can be achieved by our channel selection strategy over the conventional off-policy channel selection approaches.

  14. Evoked potential correlates of selective attention with multi-channel auditory inputs

    Science.gov (United States)

    Schwent, V. L.; Hillyard, S. A.

    1975-01-01

    Ten subjects were presented with random, rapid sequences of four auditory tones which were separated in pitch and apparent spatial position. The N1 component of the auditory vertex evoked potential (EP) measured relative to a baseline was observed to increase with attention. It was concluded that the N1 enhancement reflects a finely tuned selective attention to one stimulus channel among several concurrent, competing channels. This EP enhancement probably increases with increased information load on the subject.

  15. Estimate of Hurricane Wind Speed from AMSR-E Low-Frequency Channel Brightness Temperature Data

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    2018-01-01

    Full Text Available Two new parameters (W6H and W6V were defined that represent brightness temperature increments for different low-frequency channels due to ocean wind. We developed a new wind speed retrieval model inside hurricanes based on W6H and W6V using brightness temperature data from AMSR-E. The AMSR-E observations of 12 category 3–5 hurricanes from 2003 to 2011 and corresponding data from the H*wind analysis system were used to develop and validate the AMSR-E wind speed retrieval model. The results show that the mean bias and the overall root-mean-square (RMS difference of the AMSR-E retrieved wind speeds with respect to H*wind (HRD Real-time Hurricane Wind Analysis System analysis data were −0.01 m/s and 2.66 m/s, respectively. One case study showed that W6H and W6V were less sensitive to rain than the observed AMSR-E C-band and X-band brightness temperature data. The AMSR-E retrieval model was further validated by comparing the retrieved wind speeds against stepped-frequency microwave radiometer (SFMR measurements. The comparison showed an RMS difference of 3.41 m/s and a mean bias of 0.49 m/s.

  16. Robust EEG Channel Selection across Subjects for Brain-Computer Interfaces

    Directory of Open Access Journals (Sweden)

    Lal Thomas Navin

    2005-01-01

    Full Text Available Most EEG-based brain-computer interface (BCI paradigms come along with specific electrode positions, for example, for a visual-based BCI, electrode positions close to the primary visual cortex are used. For new BCI paradigms it is usually not known where task relevant activity can be measured from the scalp. For individual subjects, Lal et al. in 2004 showed that recording positions can be found without the use of prior knowledge about the paradigm used. However it remains unclear to what extent their method of recursive channel elimination (RCE can be generalized across subjects. In this paper we transfer channel rankings from a group of subjects to a new subject. For motor imagery tasks the results are promising, although cross-subject channel selection does not quite achieve the performance of channel selection on data of single subjects. Although the RCE method was not provided with prior knowledge about the mental task, channels that are well known to be important (from a physiological point of view were consistently selected whereas task-irrelevant channels were reliably disregarded.

  17. Robust EEG Channel Selection across Subjects for Brain-Computer Interfaces

    Science.gov (United States)

    Schröder, Michael; Lal, Thomas Navin; Hinterberger, Thilo; Bogdan, Martin; Hill, N. Jeremy; Birbaumer, Niels; Rosenstiel, Wolfgang; Schölkopf, Bernhard

    2005-12-01

    Most EEG-based brain-computer interface (BCI) paradigms come along with specific electrode positions, for example, for a visual-based BCI, electrode positions close to the primary visual cortex are used. For new BCI paradigms it is usually not known where task relevant activity can be measured from the scalp. For individual subjects, Lal et al. in 2004 showed that recording positions can be found without the use of prior knowledge about the paradigm used. However it remains unclear to what extent their method of recursive channel elimination (RCE) can be generalized across subjects. In this paper we transfer channel rankings from a group of subjects to a new subject. For motor imagery tasks the results are promising, although cross-subject channel selection does not quite achieve the performance of channel selection on data of single subjects. Although the RCE method was not provided with prior knowledge about the mental task, channels that are well known to be important (from a physiological point of view) were consistently selected whereas task-irrelevant channels were reliably disregarded.

  18. Window for Optimal Frequency Operation and Reliability of 3DEG and 2DEG Channels for Oxide Microwave MESFETs and HFETs

    Science.gov (United States)

    2016-04-01

    AFRL-AFOSR-UK-TR-2016-0008 Window for optimal frequency operation and reliability of 3DEG and 2DEG channels for oxide microwave MESFETs and HFETs...TYPE Final 3. DATES COVERED (From - To) 13-Sep-2012 to 11-Sep-2015 4. TITLE AND SUBTITLE Window for optimal frequency operation and reliability of...electric field. We conclude that the ZnO 3DEG and 2DEG channels can be operated at the electron density window with better performance than at the off

  19. Efficient Fetal-Maternal ECG Signal Separation from Two Channel Maternal Abdominal ECG via Diffusion-Based Channel Selection.

    Science.gov (United States)

    Li, Ruilin; Frasch, Martin G; Wu, Hau-Tieng

    2017-01-01

    There is a need for affordable, widely deployable maternal-fetal ECG monitors to improve maternal and fetal health during pregnancy and delivery. Based on the diffusion-based channel selection, here we present the mathematical formalism and clinical validation of an algorithm capable of accurate separation of maternal and fetal ECG from a two channel signal acquired over maternal abdomen. The proposed algorithm is the first algorithm, to the best of the authors' knowledge, focusing on the fetal ECG analysis based on two channel maternal abdominal ECG signal, and we apply it to two publicly available databases, the PhysioNet non-invasive fECG database (adfecgdb) and the 2013 PhysioNet/Computing in Cardiology Challenge (CinC2013), to validate the algorithm. The state-of-the-art results are achieved when compared with other available algorithms. Particularly, the F 1 score for the R peak detection achieves 99.3% for the adfecgdb and 87.93% for the CinC2013, and the mean absolute error for the estimated R peak locations is 4.53 ms for the adfecgdb and 6.21 ms for the CinC2013. The method has the potential to be applied to other fetal cardiogenic signals, including cardiac doppler signals.

  20. Efficient Fetal-Maternal ECG Signal Separation from Two Channel Maternal Abdominal ECG via Diffusion-Based Channel Selection

    Directory of Open Access Journals (Sweden)

    Ruilin Li

    2017-05-01

    Full Text Available There is a need for affordable, widely deployable maternal-fetal ECG monitors to improve maternal and fetal health during pregnancy and delivery. Based on the diffusion-based channel selection, here we present the mathematical formalism and clinical validation of an algorithm capable of accurate separation of maternal and fetal ECG from a two channel signal acquired over maternal abdomen. The proposed algorithm is the first algorithm, to the best of the authors' knowledge, focusing on the fetal ECG analysis based on two channel maternal abdominal ECG signal, and we apply it to two publicly available databases, the PhysioNet non-invasive fECG database (adfecgdb and the 2013 PhysioNet/Computing in Cardiology Challenge (CinC2013, to validate the algorithm. The state-of-the-art results are achieved when compared with other available algorithms. Particularly, the F1 score for the R peak detection achieves 99.3% for the adfecgdb and 87.93% for the CinC2013, and the mean absolute error for the estimated R peak locations is 4.53 ms for the adfecgdb and 6.21 ms for the CinC2013. The method has the potential to be applied to other fetal cardiogenic signals, including cardiac doppler signals.

  1. High-Frequency Ground-Motion Parameters from Weak-Motion Data in the Sicily Channel and Surrounding Regions

    Science.gov (United States)

    D'Amico, Sebastiano; Akinci, Aybige; Pischiutta, Marta

    2018-03-01

    In this paper we characterize the high frequency (1.0 - 10 Hz) seismic wave crustal attenuation and the source excitation in the Sicily Channel and surrounding regions using background seismicity from weak-motion database. The data set includes 15995 waveforms related to earthquakes having local magnitude ranging from 2.0 to 4.5 recorded between 2006 and 2012. The observed and predicted ground motions form the weak-motion data are evaluated in several narrow frequency bands from 0.25 to 20.0 Hz. The filtered observed peaks are regressed to specify a proper functional form for the regional attenuation, excitation and site specific term separately. The results are then used to calibrate effective theoretical attenuation and source excitation models using the Random Vibration Theory (RVT). In the log-log domain, the regional seismic wave attenuation and the geometrical spreading coefficient are modeled together. The geometrical spreading coefficient, g (r), modeled with a bilinear piecewise functional form and given as g (r) ∝ r-1.0 for the short distances (r selected reference distance with a magnitude independent roll-off spectral parameter, κ 0.04 s and with a Brune stress drop parameter increasing with moment magnitude, from Δσ = 2 MPa for Mw = 2.0 to Δσ = 13 MPa for Mw = 4.5. For events M≤4.5 (being Mwmax = 4.5 available in the dataset) the stress parameters are obtained by correlating the empirical/excitation source spectra with the Brune spectral model as function of magnitude. For the larger magnitudes (Mw>4.5) outside the range available in the calibration dataset where we do not have recorded data, we extrapolate our results through the calibration of the stress parameters of the Brune source spectrum over the Bindi et al. (2011) ground motion prediction equation (GMPE) selected as a reference model (hereafter also ITA10).

  2. Spectral region identification versus individual channel selection in supervised dimensionality reduction of hyperspectral image data

    Science.gov (United States)

    Aria, S. Enayat Hosseini; Menenti, Massimo; Gorte, Ben G. H.

    2017-10-01

    Hyperspectral images may be applied to classify objects in a scene. The redundancy in hyperspectral data implies that fewer spectral features might be sufficient for discriminating the objects captured in a scene. The availability of labeled classes of several areas in a scene paves the way for a supervised dimensionality reduction, i.e., using a discrimination measure between the classes in a scene to select spectral features. We show that averaging adjacent spectral channels and using wider spectral regions yield a better class separability than the selection of individual channels from the original hyperspectral dataset. We used a method named spectral region splitting (SRS), which creates a new feature space by averaging neighboring channels. In addition to the common benefits of channel selection methods, the algorithm constructs wider spectral regions when it is useful. Using different class separability measures over various datasets resulted in a better discrimination between the classes than the best-selected channels using the same measure. The reason is that the wider spectral regions led to a reduction in intraclass distances and an improvement in class discrimination. The overall classification accuracy of two hyperspectral scenes gave an increase of about two-percent when using the spectral regions determined by applying SRS.

  3. Simultaneous Channel and Feature Selection of Fused EEG Features Based on Sparse Group Lasso

    Directory of Open Access Journals (Sweden)

    Jin-Jia Wang

    2015-01-01

    Full Text Available Feature extraction and classification of EEG signals are core parts of brain computer interfaces (BCIs. Due to the high dimension of the EEG feature vector, an effective feature selection algorithm has become an integral part of research studies. In this paper, we present a new method based on a wrapped Sparse Group Lasso for channel and feature selection of fused EEG signals. The high-dimensional fused features are firstly obtained, which include the power spectrum, time-domain statistics, AR model, and the wavelet coefficient features extracted from the preprocessed EEG signals. The wrapped channel and feature selection method is then applied, which uses the logistical regression model with Sparse Group Lasso penalized function. The model is fitted on the training data, and parameter estimation is obtained by modified blockwise coordinate descent and coordinate gradient descent method. The best parameters and feature subset are selected by using a 10-fold cross-validation. Finally, the test data is classified using the trained model. Compared with existing channel and feature selection methods, results show that the proposed method is more suitable, more stable, and faster for high-dimensional feature fusion. It can simultaneously achieve channel and feature selection with a lower error rate. The test accuracy on the data used from international BCI Competition IV reached 84.72%.

  4. Diterpene Lipo-Alkaloids with Selective Activities on Cardiac K+ Channels.

    Science.gov (United States)

    Kiss, Tivadar; Borcsa, Botond; Orvos, Péter; Tálosi, László; Hohmann, Judit; Csupor, Dezső

    2017-11-01

    Aconitum diterpene alkaloids are known for their remarkable toxicity, which is due to their effect on ion channels. Activation of voltage-gated Na + channels is the major cause of their cardiotoxicity, however, influence on K + channels may also play a role in the overall effect.Here we report the synthesis of a series of lipo-alkaloids, including four new compounds, based on the 14-benzoylaconine structure, which is the core of a vast number of diterpene alkaloids naturally occurring in Aconitum species. The activities of these compounds were measured in vitro on K + ion channels using the whole-cell patch-clamp technique. Structure-activity analysis was carried out based on the data of 51 compounds (32 genuine diterpene alkaloids, 5 fatty acids, and 14 lipo-alkaloids). Depending on their substitution, these compounds exert different activities on GIRK (G protein-coupled inwardly-rectifying potassium channel) and hERG (human ether-à-go-go-related gene) channels. Fatty acids and diterpene alkaloids show lower activity on the GIRK channel than lipo-alkaloids. Lipo-alkaloids also have less pronounced hERG inhibitory activity compared to the cardiotoxic aconitine. Considering the GIRK/hERG selectivity as an indicator of perspective therapeutic applicability, lipo-alkaloids are significantly more selective than the genuine diterpene alkaloids. 14-Benzoyl-8- O -eicosa-8 Z ,11 Z ,14 Z -trienoate and 14-benzoyl-8- O -eicosa-11 Z ,14 Z ,17 Z -trienoate are strong and selective inhibitors of GIRK channels, thus, they are promising subjects for further studies to develop diterpene alkaloid-based antiarrhythmic pharmacons. Georg Thieme Verlag KG Stuttgart · New York.

  5. Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities

    Directory of Open Access Journals (Sweden)

    Saleem Aslam

    2016-12-01

    Full Text Available This paper highlights three critical aspects of the internet of things (IoTs, namely (1 energy efficiency, (2 energy balancing and (3 quality of service (QoS and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones.

  6. Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities.

    Science.gov (United States)

    Aslam, Saleem; Hasan, Najam Ul; Jang, Ju Wook; Lee, Kyung-Geun

    2016-12-02

    This paper highlights three critical aspects of the internet of things (IoTs), namely (1) energy efficiency, (2) energy balancing and (3) quality of service (QoS) and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF) energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH) on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP)-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU) activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones.

  7. Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities

    Science.gov (United States)

    Aslam, Saleem; Hasan, Najam Ul; Jang, Ju Wook; Lee, Kyung-Geun

    2016-01-01

    This paper highlights three critical aspects of the internet of things (IoTs), namely (1) energy efficiency, (2) energy balancing and (3) quality of service (QoS) and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF) energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH) on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP)-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU) activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones. PMID:27918424

  8. Low-Complexity User Selection for Rate Maximization in MIMO Broadcast Channels with Downlink Beamforming

    Directory of Open Access Journals (Sweden)

    Eduardo Castañeda

    2014-01-01

    Full Text Available We present in this work a low-complexity algorithm to solve the sum rate maximization problem in multiuser MIMO broadcast channels with downlink beamforming. Our approach decouples the user selection problem from the resource allocation problem and its main goal is to create a set of quasiorthogonal users. The proposed algorithm exploits physical metrics of the wireless channels that can be easily computed in such a way that a null space projection power can be approximated efficiently. Based on the derived metrics we present a mathematical model that describes the dynamics of the user selection process which renders the user selection problem into an integer linear program. Numerical results show that our approach is highly efficient to form groups of quasiorthogonal users when compared to previously proposed algorithms in the literature. Our user selection algorithm achieves a large portion of the optimum user selection sum rate (90% for a moderate number of active users.

  9. Effects of Carrier Frequency Offset, Timing Offset, and Channel Spread Factor on the Performance of Hexagonal Multicarrier Modulation Systems

    Directory of Open Access Journals (Sweden)

    Kui Xu

    2009-01-01

    Full Text Available Hexagonal multicarrier modulation (HMM system is the technique of choice to overcome the impact of time-frequency dispersive transmission channel. This paper examines the effects of insufficient synchronization (carrier frequency offset, timing offset on the amplitude and phase of the demodulated symbol by using a projection receiver in hexagonal multicarrier modulation systems. Furthermore, effects of CFO, TO, and channel spread factor on the performance of signal-to-interference-plus-noise ratio (SINR in hexagonal multicarrier modulation systems are further discussed. The exact SINR expression versus insufficient synchronization and channel spread factor is derived. Theoretical analysis shows that similar degradation on symbol amplitude and phase caused by insufficient synchronization is incurred as in traditional cyclic prefix orthogonal frequency-division multiplexing (CP-OFDM transmission. Our theoretical analysis is confirmed by numerical simulations in a doubly dispersive (DD channel with exponential delay power profile and U-shape Doppler power spectrum, showing that HMM systems outperform traditional CP-OFDM systems with respect to SINR against ISI/ICI caused by insufficient synchronization and doubly dispersive channel.

  10. Optimal Training for Time-Selective Wireless Fading Channels Using Cutoff Rate

    Directory of Open Access Journals (Sweden)

    Tong Lang

    2006-01-01

    Full Text Available We consider the optimal allocation of resources—power and bandwidth—between training and data transmissions for single-user time-selective Rayleigh flat-fading channels under the cutoff rate criterion. The transmitter exploits statistical channel state information (CSI in the form of the channel Doppler spectrum to embed pilot symbols into the transmission stream. At the receiver, instantaneous, though imperfect, CSI is acquired through minimum mean-square estimation of the channel based on some set of pilot observations. We compute the ergodic cutoff rate for this scenario. Assuming estimator-based interleaving and -PSK inputs, we study two special cases in-depth. First, we derive the optimal resource allocation for the Gauss-Markov correlation model. Next, we validate and refine these insights by studying resource allocation for the Jakes model.

  11. Performance of Antenna Selection in MIMO System Using Channel Reciprocity with Measured Data

    Directory of Open Access Journals (Sweden)

    Peerapong Uthansakul

    2011-01-01

    Full Text Available The channel capacity of MIMO system increases as a function of antenna pairs between transmitter and receiver but it suffers from multiple expensive RF chains. To reduce cost of RF chains, antenna selection (AS method can offer a good tradeoff between expense and performance. For a transmitting AS system, channel state information (CSI feedback is required to choose the best subset of available antennas. However, the delay and error in feedback channel are the most dominant factors to degrade performances. In this paper, the concept of AS method using reciprocal CSI instead of feedback channel is proposed. The capacity performance of proposed system is investigated by own developing Testbed. The obtained results indicate that the reciprocity technique offers a capacity close to a system with perfect CSI and gains a higher capacity than a system without AS method. This benefit is from 0.9 to 2.2 bps/Hz at SNR 10 dB.

  12. Aluminium and hydrogen ions inhibit a mechanosensory calcium-selective cation channel

    Science.gov (United States)

    Ding, J. P.; Pickard, B. G.

    1993-01-01

    The tension-dependent activity of mechanosensory calcium-selective cation channels in excised plasmalemmal patches from onion bulb scale epidermis is modulated by pH in the physiologically meaningful range between 4.5 and 7.2. It is rapidly lowered by lowering pH and rapidly raised by raising pH. Channel activity is effectively inhibited by low levels of aluminium ions and activity can be partially restored by washing for a few minutes. We suggest that under normal conditions the sensitivity of the mechanosensory channels to pH of the wall free space plays important roles in regulation of plant activities such as growth. We further suggest that, when levels of acid and aluminium ions in the soil solution are high, they might inhibit similar sensory channels in cells of the root tip, thus contributing critically to the acid soil syndrome.

  13. Substrate integrated ferrite phase shifters and active frequency selective surfaces

    International Nuclear Information System (INIS)

    Cahill, B.M.

    2002-01-01

    There are two distinct parts to this thesis; the first investigates the use of ferrite tiles in the construction of printed phase shifting transmission lines, culminating in the design of two compact electromagnetic controlled beam steered patch and slot antenna arrays. The second part investigates the use of active frequency selective surfaces (AFSS), which are later used to cover a uPVC constructed enclosure. Field intensity measurements are taken from within the enclosure to determine the dynamic screening effectiveness. Trans Tech G-350 Ferrite is investigated to determine its application in printed microstrip and stripline phase shifting transmission lines. 50-Ohm transmission lines are constructed using the ferrite tile and interfaced to Rogers RT Duroid 5870 substrate. Scattering parameter measurements are made under the application of variable magnetic fields to the ferrite. Later, two types of planar microwave beam steering antennas are constructed. The first uses the ferrites integrated into the Duroid as microstrip lines with 3 patch antennas as the radiating elements. The second uses stripline transmission lines, with slot antennas as the radiating sources etched into the ground plane of the triplate. Beam steering is achieved by the application of an external electromagnet. An AFSS is constructed by the interposition of PIN diodes into a dipole FSS array. Transmission response measurements are then made for various angles of electromagnetic wave incidence. Two states of operation exist: when a current is passed through the diodes and when the diodes are switched off. These two states form a high pass and band stop space filter respectively. An enclosure covered with the AFSS is constructed and externally illuminated in the range 2.0 - 2.8GHz. A probe antenna inside the enclosure positioned at various locations through out the volume is used to establish the effective screening action of the AFSS in 3 dimensional space. (author)

  14. Overlay Cognitive Radios With Channel-Aware Adaptive Link Selection and Buffer-Aided Relaying

    KAUST Repository

    Shaqfeh, Mohammad

    2015-08-01

    The aim of this work is to maximize the long-term average achievable rate region of a primary and a secondary source-destination pairs operating in an overlay setup over block-fading channels. To achieve this objective, we propose an opportunistic strategy to grant channel access to the primary and secondary sources based on the channel conditions in order to exploit the available multiple-link diversity gains in the system. The secondary source has causal knowledge of the primary messages and it acts as a relay of the primary source in return for getting access to the channel. To maximize the gains of relaying, the relay and destination are equipped with buffers to enable the use of channel-aware adaptive link selection. We propose and optimize different link selection policies and characterize their expected achievable rates. Also, we provide several numerical results to demonstrate the evident mutual benefits of buffer-aided cooperation and adaptive link selection to the primary and the secondary source-destination pairs. © 1972-2012 IEEE.

  15. Optical Transmitter Terminal for Selective RF High Frequency Bans

    Data.gov (United States)

    National Aeronautics and Space Administration — Recent improvements in multiplexing systems and tunable laser semiconductor diodes make the use of Wavelength Division Multiplexing to combine multiple frequency...

  16. Atrial-selective K+ channel blockers: potential antiarrhythmic drugs in atrial fibrillation?

    Science.gov (United States)

    Ravens, Ursula

    2017-11-01

    In the wake of demographic change in Western countries, atrial fibrillation has reached an epidemiological scale, yet current strategies for drug treatment of the arrhythmia lack sufficient efficacy and safety. In search of novel medications, atrial-selective drugs that specifically target atrial over other cardiac functions have been developed. Here, I will address drugs acting on potassium (K + ) channels that are either predominantly expressed in atria or possess electrophysiological properties distinct in atria from ventricles. These channels include the ultra-rapidly activating, delayed outward-rectifying Kv1.5 channel conducting I Kur , the acetylcholine-activated inward-rectifying Kir3.1/Kir3.4 channel conducting I K,ACh , the Ca 2+ -activated K + channels of small conductance (SK) conducting I SK , and the two-pore domain K + (K2P) channels (tandem of P domains, weak inward-rectifying K + channels (TWIK-1), TWIK-related acid-sensitive K + channels (TASK-1 and TASK-3)) that are responsible for voltage-independent background currents I TWIK-1 , I TASK-1 , and I TASK-3 . Direct drug effects on these channels are described and their putative value in treatment of atrial fibrillation is discussed. Although many potential drug targets have emerged in the process of unravelling details of the pathophysiological mechanisms responsible for atrial fibrillation, we do not know whether novel antiarrhythmic drugs will be more successful when modulating many targets or a single specific one. The answer to this riddle can only be solved in a clinical context.

  17. Machinery Fault Diagnosis Using Two-Channel Analysis Method Based on Fictitious System Frequency Response Function

    Directory of Open Access Journals (Sweden)

    Kihong Shin

    2015-01-01

    Full Text Available Most existing techniques for machinery health monitoring that utilize measured vibration signals usually require measurement points to be as close as possible to the expected fault components of interest. This is particularly important for implementing condition-based maintenance since the incipient fault signal power may be too small to be detected if a sensor is located further away from the fault source. However, a measurement sensor is often not attached to the ideal point due to geometric or environmental restrictions. In such a case, many of the conventional diagnostic techniques may not be successfully applicable. In this paper, a two-channel analysis method is proposed to overcome such difficulty. It uses two vibration signals simultaneously measured at arbitrary points in a machine. The proposed method is described theoretically by introducing a fictitious system frequency response function. It is then verified experimentally for bearing fault detection. The results show that the suggested method may be a good alternative when ideal points for measurement sensors are not readily available.

  18. How Metastrategic Considerations Influence the Selection of Frequency Estimation Strategies

    Science.gov (United States)

    Brown, Norman R.

    2008-01-01

    Prior research indicates that enumeration-based frequency estimation strategies become increasingly common as memory for relevant event instances improves and that moderate levels of context memory are associated with moderate rates of enumeration [Brown, N. R. (1995). Estimation strategies and the judgment of event frequency. Journal of…

  19. Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity

    Science.gov (United States)

    Oliva, Romina; Calamita, Giuseppe; Thornton, Janet M.; Pellegrini-Calace, Marialuisa

    2010-01-01

    Aquaporins are homotetrameric channel proteins, which allow the diffusion of water and small solutes across biological membranes. According to their transport function, aquaporins can be divided into “orthodox aquaporins”, which allow the flux of water molecules only, and “aquaglyceroporins”, which facilitate the diffusion of glycerol and other small solutes in addition to water. The contribution of individual residues in the pore to the selectivity of orthodox aquaporins and aquaglyceroporins is not yet fully understood. To gain insights into aquaporin selectivity, we focused on the sequence variation and electrostatics of their channels. The continuum Poisson-Boltzmann electrostatic potential along the channel was calculated and compared for ten three-dimensional-structures which are representatives of different aquaporin subfamilies, and a panel of functionally characterized mutants, for which high-accuracy three-dimensional-models could be derived. Interestingly, specific electrostatic profiles associated with the main selectivity to water or glycerol could be identified. In particular: (i) orthodox aquaporins showed a distinctive electrostatic potential maximum at the periplasmic side of the channel around the aromatic/Arg (ar/R) constriction site; (ii) aquaporin-0 (AQP0), a mammalian aquaporin with considerably low water permeability, had an additional deep minimum at the cytoplasmic side; (iii) aquaglyceroporins showed a rather flat potential all along the channel; and (iv) the bifunctional protozoan PfAQP had an unusual all negative profile. Evaluation of electrostatics of the mutants, along with a thorough sequence analysis of the aquaporin pore-lining residues, illuminated the contribution of specific residues to the electrostatics of the channels and possibly to their selectivity. PMID:20147624

  20. Active Feedback Technique for RF Channel Selection in Front-End Receivers

    NARCIS (Netherlands)

    Youssef, S.S.T.; van der Zee, Ronan A.R.; Nauta, Bram

    2012-01-01

    Co-existence problems in a mobile terminal environment pose strict requirements on the linearity of a front-end receiver. In this paper, active feedback is explored as a means to relax such requirements by providing channel selectivity as early as possible in the receiver chain. The proposed

  1. Objective ARX Model Order Selection for Multi-Channel Human Operator Identification

    NARCIS (Netherlands)

    Roggenkämper, N; Pool, D.M.; Drop, F.M.; van Paassen, M.M.; Mulder, M.

    2016-01-01

    In manual control, the human operator primarily responds to visual inputs but may elect to make use of other available feedback paths such as physical motion, adopting a multi-channel control strategy. Hu- man operator identification procedures generally require a priori selection of the model

  2. Evaluation and selection of hot channel (peaking) factors for research reactor applications

    International Nuclear Information System (INIS)

    Woodruff, W.L.

    1987-01-01

    A proposed method for selecting and applying hot channel factors is presented along with some justification for these selections. The method is illustrated by example, and the sensitivity to some of the choices is examined. The uncertainty in the heat transfer coefficient is a major contributor to the reduction in thermal-hydraulic safety margins. The uncertainty introduced by the heterogeneity in the fuel is another important contributor and an area where more information may be useful in reducing this uncertainty. (Author)

  3. [Frequency-domain quantification based on the singular value decomposition and frequency-selection for magnetic resonance spectra].

    Science.gov (United States)

    Men, Kuo; Quan, Hong; Yang, Peipei; Cao, Ting; Li, Weihao

    2010-04-01

    The frequency-domain magnetic resonance spectroscopy (MRS) is achieved by the Fast Fourier Transform (FFT) of the time-domain signals. Usually we are only interested in the portion lying in a frequency band of the whole spectrum. A method based on the singular value decomposition (SVD) and frequency-selection is presented in this article. The method quantifies the spectrum lying in the interested frequency band and reduces the interference of the parts lying out of the band in a computationally efficient way. Comparative experiments with the standard time-domain SVD method indicate that the method introduced in this article is accurate and timesaving in practical situations.

  4. Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.

    Science.gov (United States)

    Dadi, Prasanna K; Vierra, Nicholas C; Days, Emily; Dickerson, Matthew T; Vinson, Paige N; Weaver, C David; Jacobson, David A

    2017-03-15

    The two-pore-domain potassium (K2P) channel TREK-2 serves to modulate plasma membrane potential in dorsal root ganglia c-fiber nociceptors, which tunes electrical excitability and nociception. Thus, TREK-2 channels are considered a potential therapeutic target for treating pain; however, there are currently no selective pharmacological tools for TREK-2 channels. Here we report the identification of the first TREK-2 selective activators using a high-throughput fluorescence-based thallium (Tl + ) flux screen (HTS). An initial pilot screen with a bioactive lipid library identified 11-deoxy prostaglandin F2α as a potent activator of TREK-2 channels (EC 50 ≈ 0.294 μM), which was utilized to optimize the TREK-2 Tl + flux assay (Z' = 0.752). A HTS was then performed with 76 575 structurally diverse small molecules. Many small molecules that selectively activate TREK-2 were discovered. As these molecules were able to activate single TREK-2 channels in excised membrane patches, they are likely direct TREK-2 activators. Furthermore, TREK-2 activators reduced primary dorsal root ganglion (DRG) c-fiber Ca 2+ influx. Interestingly, some of the selective TREK-2 activators such as 11-deoxy prostaglandin F2α were found to inhibit the K2P channel TREK-1. Utilizing chimeric channels containing portions of TREK-1 and TREK-2, the region of the TREK channels that allows for either small molecule activation or inhibition was identified. This region lies within the second pore domain containing extracellular loop and is predicted to play an important role in modulating TREK channel activity. Moreover, the selective TREK-2 activators identified in this HTS provide important tools for assessing human TREK-2 channel function and investigating their therapeutic potential for treating chronic pain.

  5. Distributed Antenna Channels with Regenerative Relaying: Relay Selection and Asymptotic Capacity

    Directory of Open Access Journals (Sweden)

    Aitor del Coso

    2007-11-01

    Full Text Available Multiple-input-multiple-output (MIMO techniques have been widely proposed as a means to improve capacity and reliability of wireless channels, and have become the most promising technology for next generation networks. However, their practical deployment in current wireless devices is severely affected by antenna correlation, which reduces their impact on performance. One approach to solve this limitation is relaying diversity. In relay channels, a set of N wireless nodes aids a source-destination communication by relaying the source data, thus creating a distributed antenna array with uncorrelated path gains. In this paper, we study this multiple relay channel (MRC following a decode-and-forward (D&F strategy (i.e., regenerative forwarding, and derive its achievable rate under AWGN. A half-duplex constraint on relays is assumed, as well as distributed channel knowledge at both transmitter and receiver sides of the communication. For this channel, we obtain the optimum relay selection algorithm and the optimum power allocation within the network so that the transmission rate is maximized. Likewise, we bound the ergodic performance of the achievable rate and derive its asymptotic behavior in the number of relays. Results show that the achievable rate of regenerative MRC grows as the logarithm of the Lambert W function of the total number of relays, that is, 𝒞=log⁡2(W0(N. Therefore, D&F relaying, cannot achieve the capacity of actual MISO channels.

  6. Distributed Antenna Channels with Regenerative Relaying: Relay Selection and Asymptotic Capacity

    Directory of Open Access Journals (Sweden)

    del Coso Aitor

    2007-01-01

    Full Text Available Multiple-input-multiple-output (MIMO techniques have been widely proposed as a means to improve capacity and reliability of wireless channels, and have become the most promising technology for next generation networks. However, their practical deployment in current wireless devices is severely affected by antenna correlation, which reduces their impact on performance. One approach to solve this limitation is relaying diversity. In relay channels, a set of wireless nodes aids a source-destination communication by relaying the source data, thus creating a distributed antenna array with uncorrelated path gains. In this paper, we study this multiple relay channel (MRC following a decode-and-forward (D&F strategy (i.e., regenerative forwarding, and derive its achievable rate under AWGN. A half-duplex constraint on relays is assumed, as well as distributed channel knowledge at both transmitter and receiver sides of the communication. For this channel, we obtain the optimum relay selection algorithm and the optimum power allocation within the network so that the transmission rate is maximized. Likewise, we bound the ergodic performance of the achievable rate and derive its asymptotic behavior in the number of relays. Results show that the achievable rate of regenerative MRC grows as the logarithm of the Lambert W function of the total number of relays, that is, . Therefore, D&F relaying, cannot achieve the capacity of actual MISO channels.

  7. TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel.

    Science.gov (United States)

    Hofmann, Thomas; Chubanov, Vladimir; Gudermann, Thomas; Montell, Craig

    2003-07-01

    The TRPM subfamily of mammalian TRP channels displays unusually diverse activation mechanisms and selectivities. One member of this subfamily, TRPM5, functions in taste receptor cells and has been reported to be activated through G protein-coupled receptors linked to phospholipase C. However, the specific mechanisms regulating TRPM5 have not been described. Here, we demonstrate that TRPM5 is a monovalent-specific cation channel with a 23 pS unitary conductance. TRPM5 does not display constitutive activity. Rather, it is activated by stimulation of a receptor pathway coupled to phospholipase C and by IP(3)-mediated Ca(2+) release. Gating of TRPM5 was dependent on a rise in Ca(2+) because it was fully activated by Ca(2+). Unlike any previously described mammalian TRP channel, TRPM5 displayed voltage modulation and rapid activation and deactivation kinetics upon receptor stimulation. The most closely related protein, the Ca(2+)-activated monovalent-selective cation channel TRPM4b, also showed voltage modulation, although with slower relaxation kinetics than TRPM5. Taken together, the data demonstrate that TRPM5 and TRPM4b represent the first examples of voltage-modulated, Ca(2+)-activated, monovalent cation channels (VCAMs). The voltage modulation and rapid kinetics provide TRPM5 with an excellent set of properties for participating in signaling in taste receptors and other excitable cells.

  8. Controls on the distribution of channel reach morphology in selectively glaciated catchments

    Science.gov (United States)

    Addy, S.; Soulsby, C.; Hartley, A. J.

    2014-04-01

    To assess the controls on the distribution of channel reach morphology in a selectively glaciated landscape, we used field mapping and a geographical information system (GIS) in the River Dee catchment, northeast Scotland. Controls on channel morphology were investigated using (1) continuous longitudinal assessment of channel morphology distribution in relation to geology, glacial history, topography, and total stream power (Ω) in two subcatchments, and (2) slope (S), Ω, and a slope-drainage area (S-A) framework to understand the occurrence of 173 widely distributed bedrock, mixed bedrock-alluvial, and alluvial (three different types) reaches. The S-A framework used indicators of transport capacity (Qc) and sediment supply (Qs) to differentiate channel types. The study highlights the disjointed nature of channel reach distribution at the river scale that reflects variable lithology and glacial modification. Because of the subdued topography in contrast to other regions, colluvial forcing of channel morphology in the headwaters was lacking. However, in common with other glaciated landscapes, repeated sequences of channel reach type progression determined by valley steps were evident. The S-A analysis successfully discriminated 87.2% of alluvial and 91.4% of bedrock reaches despite the variable land use and glacial modification. Discrimination of the full range of channel types using S, Ω, or the S-A framework was poor however. Notably, a third of the transport alluvial reaches were located in the bedrock S-A domain, and the majority of mixed reaches were widely distributed mostly within the bedrock domain and not close to the critical slope (Sc). In comparison to other regions, the Sc above which Qc > Qs and bedrock reaches dominate, was notably higher. We hypothesise that a drier climate and the higher entrainment threshold of coarse, granite-dominated bed materials create a higher Sc.

  9. Isotachophoresis system having larger-diameter channels flowing into channels with reduced diameter and with selectable counter-flow

    Energy Technology Data Exchange (ETDEWEB)

    Mariella, Jr., Raymond P.

    2018-03-06

    An isotachophoresis system for separating a sample containing particles into discrete packets including a flow channel, the flow channel having a large diameter section and a small diameter section; a negative electrode operably connected to the flow channel; a positive electrode operably connected to the flow channel; a leading carrier fluid in the flow channel; a trailing carrier fluid in the flow channel; and a control for separating the particles in the sample into discrete packets using the leading carrier fluid, the trailing carrier fluid, the large diameter section, and the small diameter section.

  10. Channel capacity of TDD-OFDM-MIMO for multiple access points in a wireless single-frequency-network

    DEFF Research Database (Denmark)

    Takatori, Y.; Fitzek, Frank; Tsunekawa, K.

    2005-01-01

    MIMO data transmission scheme, which combines Single-Frequency-Network (SFN) with TDD-OFDM-MIMO applied for wireless LAN networks. In our proposal, we advocate to use SFN for multiple access points (MAP) MIMO data transmission. The goal of this approach is to achieve very high channel capacity in both...... LOS and non line of sight (NLOS) environments. The channel capacity of the proposed method is derived for the direct path environments and it confirms the effectiveness of the proposed scheme in the LOS scenario. Moreover, solid computer simulation results confirm the effectiveness of the proposed...

  11. Outage performance of Decode-and-Forward partial selection in Nakagami-m fading channels

    KAUST Repository

    Benjillali, Mustapha

    2010-01-01

    In this paper, we investigate the outage performance of Decode-and-Forward with partial selection relaying in dualhop cooperative Nakagami-m fading links. The source, based on the unique knowledge of local first hop channel state information, selects the best relay to increase the chances of successful decoding and hence the possibility of cooperation when the direct link is also available. After deriving the exact distribution of the sum of two gamma variates with the same shape parameter, the outage probability of the system-with and without the direct link-is obtained in closed-form. We also derive the ε-outage capacity in different particular cases, and the obtained results- when the channel model is reduced to a Rayleigh fading-are either new or correspond to those previously obtained in other works. Simulation results confirm the accuracy of our analysis for a large selection of system and fading parameters. © 2009 IEEE.

  12. Iterative Frequency-Domain Channel Estimation and Equalization for Ultra-Wideband Systems with Short Cyclic Prefix

    Directory of Open Access Journals (Sweden)

    Salim Bahçeci

    2010-01-01

    Full Text Available In impulse radio ultra-wideband (IR-UWB systems where the channel lengths are on the order of a few hundred taps, conventional use of frequency-domain (FD processing for channel estimation and equalization may not be feasible because the need to add a cyclic prefix (CP to each block causes a significant reduction in the spectral efficiency. On the other hand, using no or short CP causes the interblock interference (IBI and thus degradation in the receiver performance. Therefore, in order to utilize FD receiver processing UWB systems without a significant loss in the spectral efficiency and the performance, IBI cancellation mechanisms are needed in both the channel estimation and equalization operations. For this reason, in this paper, we consider the joint FD channel estimation and equalization for IR-UWB systems with short cyclic prefix (CP and propose a novel iterative receiver employing soft IBI estimation and cancellation within both its FD channel estimator and FD equalizer components. We show by simulation results that the proposed FD receiver attains performances close to that of the full CP case in both line-of-sight (LOS and non-line-of-sight (NLOS UWB channels after only a few iterations.

  13. Food and beverage advertising on children's TV channels in Argentina: Frequency, duration, and nutritional quality.

    Science.gov (United States)

    Rovirosa, Alicia; Zapata, María E; Gómez, Paula; Gotthelf, Susana; Ferrante, Daniel

    2017-02-01

    Food and beverage marketing has been identified as one of the determinants of unhealthy food and beverage consumption in the child population. To determine the frequency and duration of food and beverage advertising in children's programming and the nutritional quality of advertised food and beverages. Descriptive, cross-sectional study. Children's cable and broadcast channel programming was recorded in two periods: over the week and on the weekend. The type, quantity, and duration of commercials were recorded. The nutritional quality of advertised food and beverages was analyzed. A total of 402.3 hours of children's programming were recorded. In total, 3711 commercials were identified. Among these, 20.9% corresponded to food and beverages, i.e., an average of 1.9 ± 1.0 commercials per hour or equivalent to 0.68 ± 0.36 min/hour. Dairy products, candies, and fast-food meals were the most advertised food products. Only a third of advertised food and beverages (35.8%) were categorized as healthy as per the nutrient profiling system. Based on the traffic light labeling system, 50% of advertised food and beverages were high in sugar, 25% were high in saturated fat, and approximately 15% were high in sodium or fat. Food and beverage advertising accounted for 20% of television advertising time. The most advertised products were dairy products, followed by candies and sweet snacks, fast-food meals, and beverages. Two-thirds of advertised food and beverages were considered unhealthy. Sociedad Argentina de Pediatría

  14. DPPX potassium channel antibody: frequency, clinical accompaniments, and outcomes in 20 patients.

    Science.gov (United States)

    Tobin, William Oliver; Lennon, Vanda A; Komorowski, Lars; Probst, Christian; Clardy, Stacey Lynn; Aksamit, Allen J; Appendino, Juan Pablo; Lucchinetti, Claudia F; Matsumoto, Joseph Y; Pittock, Sean J; Sandroni, Paola; Tippmann-Peikert, Maja; Wirrell, Elaine C; McKeon, Andrew

    2014-11-11

    To describe the detection frequency and clinical associations of immunoglobulin G (IgG) targeting dipeptidyl-peptidase-like protein-6 (DPPX), a regulatory subunit of neuronal Kv4.2 potassium channels. Specimens from 20 patients evaluated on a service basis by tissue-based immunofluorescence yielded a synaptic immunostaining pattern consistent with DPPX-IgG (serum, 20; CSF, all 7 available). Transfected HEK293 cell-based assay confirmed DPPX specificity in all specimens. Sixty-nine patients with stiff-person syndrome and related disorders were also evaluated by DPPX-IgG cell-based assay. Of 20 seropositive patients, 12 were men; median symptom onset age was 53 years (range, 13-75). Symptom onset was insidious in 15 and subacute in 5. Twelve patients reported prodromal weight loss. Neurologic disorders were multifocal. All had one or more brain or brainstem manifestations: amnesia (16), delirium (8), psychosis (4), depression (4), seizures (2), and brainstem disorders (15; eye movement disturbances [8], ataxia [7], dysphagia [6], dysarthria [4], respiratory failure [3]). Nine patients reported sleep disturbance. Manifestations of central hyperexcitability included myoclonus (8), exaggerated startle (6), diffuse rigidity (6), and hyperreflexia (6). Dysautonomia involved the gastrointestinal tract (9; diarrhea [6], gastroparesis, and constipation [3]), bladder (7), cardiac conduction system (3), and thermoregulation (1). Two patients had B-cell neoplasms: gastrointestinal lymphoma (1), and chronic lymphocytic leukemia (1). Substantial neurologic improvements followed immunotherapy in 7 of 11 patients with available treatment data. DPPX-IgG was not detected in any of the stiff-person syndrome patients. DPPX-IgG is a biomarker for an immunotherapy-responsive multifocal neurologic disorder of the central and autonomic nervous systems. © 2014 American Academy of Neurology.

  15. EMG feature assessment for myoelectric pattern recognition and channel selection: a study with incomplete spinal cord injury.

    Science.gov (United States)

    Liu, Jie; Li, Xiaoyan; Li, Guanglin; Zhou, Ping

    2014-07-01

    Myoelectric pattern recognition with a large number of electromyogram (EMG) channels provides an approach to assessing motor control information available from the recorded muscles. In order to develop a practical myoelectric control system, a feature dependent channel reduction method was developed in this study to determine a small number of EMG channels for myoelectric pattern recognition analysis. The method selects appropriate raw EMG features for classification of different movements, using the minimum Redundancy Maximum Relevance (mRMR) and the Markov random field (MRF) methods to rank a large number of EMG features, respectively. A k-nearest neighbor (KNN) classifier was used to evaluate the performance of the selected features in terms of classification accuracy. The method was tested using 57 channels' surface EMG signals recorded from forearm and hand muscles of individuals with incomplete spinal cord injury (SCI). Our results demonstrate that appropriate selection of a small number of raw EMG features from different recording channels resulted in similar high classification accuracies as achieved by using all the EMG channels or features. Compared with the conventional sequential forward selection (SFS) method, the feature dependent method does not require repeated classifier implementation. It can effectively reduce redundant information not only cross different channels, but also cross different features in the same channel. Such hybrid feature-channel selection from a large number of EMG recording channels can reduce computational cost for implementation of a myoelectric pattern recognition based control system. Copyright © 2014 IPEM. Published by Elsevier Ltd. All rights reserved.

  16. Frequency selection for coda wave interferometry in concrete structures.

    Science.gov (United States)

    Fröjd, Patrik; Ulriksen, Peter

    2017-09-01

    This study contributes to the establishment of frequency recommendations for use in coda wave interferometry structural health monitoring (SHM) systems for concrete structures. To this end, codas with widely different central frequencies were used to detect boreholes with different diameters in a large concrete floor slab, and to track increasing damage in a small concrete beam subjected to bending loads. SHM results were obtained for damage that can be simulated by drilled holes on the scale of a few mm or microcracks due to bending. These results suggest that signals in the range of 50-150kHz are suitable in large concrete structures where it is necessary to account for the high attenuation of high-frequency signals. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  17. Transmit selection for imperfect threshold-based receive MRC in Rayleigh fading channels

    KAUST Repository

    Radaydeh, Redha Mahmoud Mesleh

    2010-01-01

    The performance of multiple-antenna diversity systems in which the receiver combines signal replicas per thresholdbased maximal ratio combining (MRC) and the transmitter uses only a single antenna according to receive combined signal strength is studied. The impact of imperfect channel estimation is considered when the received signal replicas undergo independent and flat multipath fading. The analysis is applicable for arbitrary transmit antenna selection when the multiple-antenna channels experience identically distributed and non-identically distributed Rayleigh fading conditions. New closed-form expressions for the combined SNR statistics and some performance measures are presented. The system models adopted herein and the presented analytical results can be used to study the performance of different system architectures under various channel conditions when the implementation complexity is of interest. © 2009 IEEE.

  18. 47 CFR 90.621 - Selection and assignment of frequencies.

    Science.gov (United States)

    2010-10-01

    ... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Regulations Governing Licensing and Use of Frequencies in the 806-824, 851-869, 896-901, and 935-940 MHz Bands Policies Governing the Processing of Applications and... the Public Safety and Business/Industrial/Land Transportation Categories must specify on the...

  19. Assessing the copula selection for bivariate frequency analysis ...

    Indian Academy of Sciences (India)

    58

    37 frequency analysis methods cannot describe the random variable properties that are correlated. 38. (Sarhadi et al., 2016). This approach can lead to high uncertainty or failure of guidelines in. 39 water resources planning, operation and design of hydraulic structures or creating the flood risk. 40 mapping (Chebana and ...

  20. EEG Channel Selection Using Particle Swarm Optimization for the Classification of Auditory Event-Related Potentials

    Directory of Open Access Journals (Sweden)

    Alejandro Gonzalez

    2014-01-01

    Full Text Available Brain-machine interfaces (BMI rely on the accurate classification of event-related potentials (ERPs and their performance greatly depends on the appropriate selection of classifier parameters and features from dense-array electroencephalography (EEG signals. Moreover, in order to achieve a portable and more compact BMI for practical applications, it is also desirable to use a system capable of accurate classification using information from as few EEG channels as possible. In the present work, we propose a method for classifying P300 ERPs using a combination of Fisher Discriminant Analysis (FDA and a multiobjective hybrid real-binary Particle Swarm Optimization (MHPSO algorithm. Specifically, the algorithm searches for the set of EEG channels and classifier parameters that simultaneously maximize the classification accuracy and minimize the number of used channels. The performance of the method is assessed through offline analyses on datasets of auditory ERPs from sound discrimination experiments. The proposed method achieved a higher classification accuracy than that achieved by traditional methods while also using fewer channels. It was also found that the number of channels used for classification can be significantly reduced without greatly compromising the classification accuracy.

  1. Finite-SNR analysis for partial relaying cooperation with channel coding and opportunistic relay selection

    Science.gov (United States)

    Vu, Thang X.; Duhamel, Pierre; Chatzinotas, Symeon; Ottersten, Bjorn

    2017-12-01

    This work studies the performance of a cooperative network which consists of two channel-coded sources, multiple relays, and one destination. To achieve high spectral efficiency, we assume that a single time slot is dedicated to relaying. Conventional network-coded-based cooperation (NCC) selects the best relay which uses network coding to serve the two sources simultaneously. The bit error rate (BER) performance of NCC with channel coding, however, is still unknown. In this paper, we firstly study the BER of NCC via a closed-form expression and analytically show that NCC only achieves diversity of order two regardless of the number of available relays and the channel code. Secondly, we propose a novel partial relaying-based cooperation (PARC) scheme to improve the system diversity in the finite signal-to-noise ratio (SNR) regime. In particular, closed-form expressions for the system BER and diversity order of PARC are derived as a function of the operating SNR value and the minimum distance of the channel code. We analytically show that the proposed PARC achieves full (instantaneous) diversity order in the finite SNR regime, given that an appropriate channel code is used. Finally, numerical results verify our analysis and demonstrate a large SNR gain of PARC over NCC in the SNR region of interest.

  2. Game Theoretical Approaches for Transport-Aware Channel Selection in Cognitive Radio Networks

    Directory of Open Access Journals (Sweden)

    Chen Shih-Ho

    2010-01-01

    Full Text Available Effectively sharing channels among secondary users (SUs is one of the greatest challenges in cognitive radio network (CRN. In the past, many studies have proposed channel selection schemes at the physical or the MAC layer that allow SUs swiftly respond to the spectrum states. However, they may not lead to enhance performance due to slow response of the transport layer flow control mechanism. This paper presents a cross-layer design framework called Transport Aware Channel Selection (TACS scheme to optimize the transport throughput based on states, such as RTT and congestion window size, of TCP flow control mechanism. We formulate the TACS problem as two different game theoretic approaches: Selfish Spectrum Sharing Game (SSSG and Cooperative Spectrum Sharing Game (CSSG and present novel distributed heuristic algorithms to optimize TCP throughput. Computer simulations show that SSSG and CSSG could double the SUs throughput of current MAC-based scheme when primary users (PUs use their channel infrequently, and with up to 12% to 100% throughput increase when PUs are more active. The simulation results also illustrated that CSSG performs up to 20% better than SSSG in terms of the throughput.

  3. Sparse Non-negative Tensor 2D Deconvolution (SNTF2D) for multi channel time-frequency analysis

    DEFF Research Database (Denmark)

    Mørup, Morten; Schmidt, Mikkel N.

    2006-01-01

    We recently introduced two algorithms for sparse non-negative matrix factor 2-D deconvolution (SNMF2D) that are useful for single channel source separation and music transcription. We here extend this approach to the analysis of the log-frequency spectrograms of a multichannel recording. The model....... The algorithms are demonstrated to successfully identify the components of both artificially generated as well as real stereo music....

  4. Selecting participants for listening tests of multi-channel reproduced sound

    DEFF Research Database (Denmark)

    Wickelmaier, Florian; Choisel, Sylvain

    2005-01-01

    A selection procedure was devised in order to select listeners for experiments in which their main task will be to judge multi-channel reproduced sound. 91 participants filled in a web-based questionnaire. 78 of them took part in an assessment of their hearing thresholds, their spatial hearing......, and their verbal production abilities. The listeners displayed large individual differences in their performance. 40 subjects were selected based on the test results. The self-assessed listening habits and experience in the web questionnaire could not predict the results of the selection procedure. Further......, the hearing thresholds did not correlate with the spatial-hearing test. This leads to the conclusion that task-specific performance tests might be the preferable means of selecting a listening panel....

  5. Asymptotic analysis for Nakagami-m fading channels with relay selection

    KAUST Repository

    Zhong, Caijun

    2011-06-01

    In this paper, we analyze the asymptotic outage probability performance of both decode-and-forward (DF) and amplify-and-forward (AF) relaying systems using partial relay selection and the "best" relay selection schemes for Nakagami-m fading channels. We derive their respective outage probability expressions in the asymptotic high signal-to-noise ratio (SNR) regime, from which the diversity order and coding gain are analyzed. In addition, we investigate the impact of power allocation between the source and relay terminals and derive the diversity-multiplexing tradeoff (DMT) for these relay selection systems. The theoretical findings suggest that partial relay selection can improve the diversity of the system and can achieve the same DMT as the "best" relay selection scheme under certain conditions. © 2011 IEEE.

  6. Energy and spectral efficiency analysis for selective ARQ multi-channel systems

    KAUST Repository

    Shafique, Taniya

    2017-07-31

    In this paper, we develop selective retransmission schemes for multiple-channel systems. The proposed schemes are selective automatic repeat request with fixed bandwidth (SARQ-FB), selective chase combining with fixed bandwidth (SCC-FB) and selective automatic repeat request with variable bandwidth (SARQ-VB). The main objective of the proposed schemes is to use the available power and bandwidth budget effectively along with the selective retransmission to deliver the required data successfully within a limited number of transmissions. To investigate the performance of each scheme, we first analyze the average spectral and energy efficiency and derive closed form expressions for each scheme. Then, we compare the EE and SE of each scheme through numerical results.

  7. Performance analysis of selective cooperation with fixed gain relays in Nakagami-m channels

    KAUST Repository

    Hussain, Syed Imtiaz

    2012-09-01

    Selecting the best relay using the maximum signal to noise ratio (SNR) among all the relays ready to cooperate saves system resources and utilizes the available bandwidth more efficiently compared to the regular all-relay cooperation. In this paper, we analyze the performance of the best relay selection scheme with fixed gain relays operating in Nakagami-. m channels. We first derive the probability density function (PDF) of upper bounded end-to-end SNR of the relay link. Using this PDF, we derive some key performance parameters for the system including average bit error probability and average channel capacity. The analytical results are verified through Monte Carlo simulations. © 2012 Elsevier B.V.

  8. Adaptive evolution of insect selective excitatory β-type sodium channel neurotoxins from scorpion venom.

    Science.gov (United States)

    Wu, Wenlan; Li, Zhongjie; Ma, Yibao

    2017-06-01

    Insect selective excitatory β-type sodium channel neurotoxins from scorpion venom (β-NaScTxs) are composed of about 70-76 amino acid residues and share a common scaffold stabilized by four unique disulfide bonds. The phylogenetic analysis of these toxins was hindered by limited sequence data. In our recent study, two new insect selective excitatory β-NaScTxs, LmIT and ImIT, were isolated from Lychas mucronatus and Isometrus maculatus, respectively. With the sequences previously reported, we examined the adaptive molecular evolution of insect selective excitatory β-NaScTxs by estimating the nonsynonymous-to-synonymous rate ratio (ω=d N /d S ). The results revealed 12 positively selected sites in the genes of insect selective excitatory β-NaScTxs. Moreover, these positively selected sites match well with the sites important for interacting with sodium channels, as demonstrated in previous mutagenesis study. These results reveal that adaptive evolution after gene duplication is one of the most important genetic mechanisms of scorpion neurotoxin diversification. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Path loss variation of on-body UWB channel in the frequency bands of IEEE 802.15.6 standard.

    Science.gov (United States)

    Goswami, Dayananda; Sarma, Kanak C; Mahanta, Anil

    2016-06-01

    The wireless body area network (WBAN) has gaining tremendous attention among researchers and academicians for its envisioned applications in healthcare service. Ultra wideband (UWB) radio technology is considered as excellent air interface for communication among body area network devices. Characterisation and modelling of channel parameters are utmost prerequisite for the development of reliable communication system. The path loss of on-body UWB channel for each frequency band defined in IEEE 802.15.6 standard is experimentally determined. The parameters of path loss model are statistically determined by analysing measurement data. Both the line-of-sight and non-line-of-sight channel conditions are considered in the measurement. Variations of parameter values with the size of human body are analysed along with the variation of parameter values with the surrounding environments. It is observed that the parameters of the path loss model vary with the frequency band as well as with the body size and surrounding environment. The derived parameter values are specific to the particular frequency bands of IEEE 802.15.6 standard, which will be useful for the development of efficient UWB WBAN system.

  10. Ion Selectivity Mechanism in a Bacterial Pentameric Ligand-Gated Ion Channel

    International Nuclear Information System (INIS)

    Wang, Hailong; Cheng, Xiaolin

    2011-01-01

    The proton-gated ion channel from Gloeobacter violaceus (GLIC) is a prokaryotic homolog of the eukaryotic nicotinic acetylcholine receptor (nAChR) that responds to the binding of neurotransmitter acetylcholine and mediates fast signal transmission. Recent emergence of a high resolution crystal structure of GLIC captured in a potentially open state allowed detailed, atomic-level insight into ion conduction and selectivity mechanisms in these channels. Herein, we have examined the barriers to ion conduction and origins of ion selectivity in the GLIC channel by the construction of potential of mean force (PMF) profiles for sodium and chloride ions inside the transmembrane region. Our calculations reveal that the GLIC channel is open for a sodium ion to transport, but presents a ∼10 kcal/mol free energy barrier for a chloride ion, which arises primarily from the unfavorable interactions with a ring of negatively charged glutamate residues (E-2) at the intracellular end and a ring of hydrophobic residues (I9) in the middle of the transmembrane domain. Our collective findings further suggest that the charge selection mechanism can, to a large extent, be attributed to the narrow intracellular end and a ring of glutamate residues in this position their strong negative electrostatics and ability to bind cations. By contrast, E19 at the extracellular entrance only plays a minor role in ion selectivity of GLIC. In addition to electrostatics, both ion hydration and protein dynamics are found to be crucial for ion conduction as well, which explains why a chloride ion experiences a much greater barrier than a sodium ion in the hydrophobic region of the pore.

  11. Ion Selectivity Mechanism in a Bacterial Pentameric Ligand-Gated Ion Channel

    Energy Technology Data Exchange (ETDEWEB)

    Fritsch, Sebastian M [ORNL; Ivanov, Ivaylo N [ORNL; Wang, Hailong [Mayo Clinic College of Medicine; Cheng, Xiaolin [ORNL

    2011-01-01

    The proton-gated ion channel from Gloeobacter violaceus (GLIC) is a prokaryotic homolog of the eukaryotic nicotinic acetylcholine receptor (nAChR) that responds to the binding of neurotransmitter acetylcholine and mediates fast signal transmission. Recent emergence of a high resolution crystal structure of GLIC captured in a potentially open state allowed detailed, atomic-level insight into ion conduction and selectivity mechanisms in these channels. Herein, we have examined the barriers to ion conduction and origins of ion selectivity in the GLIC channel by the construction of potential of mean force (PMF) profiles for sodium and chloride ions inside the transmembrane region. Our calculations reveal that the GLIC channel is open for a sodium ion to transport, but presents a ~10 kcal/mol free energy barrier for a chloride ion, which arises primarily from the unfavorable interactions with a ring of negatively charged glutamate residues (E-2 ) at the intracellular end and a ring of hydrophobic residues (I9 ) in the middle of the transmembrane domain. Our collective findings further suggest that the charge selection mechanism can, to a large extent, be attributed to the narrow intracellular end and a ring of glutamate residues in this position their strong negative electrostatics and ability to bind cations. By contrast, E19 at the extracellular entrance only plays a minor role in ion selectivity of GLIC. In addition to electrostatics, both ion hydration and protein dynamics are found to be crucial for ion conduction as well, which explains why a chloride ion experiences a much greater barrier than a sodium ion in the hydrophobic region of the pore.

  12. Two stable, conducting conformations of the selectivity filter in Shaker K+ channels.

    Science.gov (United States)

    Thompson, Jill; Begenisich, Ted

    2005-06-01

    We have examined the voltage dependence of external TEA block of Shaker K(+) channels over a range of internal K(+) concentrations from 2 to 135 mM. We found that the concentration dependence of external TEA block in low internal K(+) solutions could not be described by a single TEA binding affinity. The deviation from a single TEA binding isotherm was increased at more depolarized membrane voltages. The data were well described by a two-component binding scheme representing two, relatively stable populations of conducting channels that differ in their affinity for external TEA. The relative proportion of these two populations was not much affected by membrane voltage but did depend on the internal K(+) concentration. Low internal K(+) promoted an increase in the fraction of channels with a low TEA affinity. The voltage dependence of the apparent high-affinity TEA binding constant depended on the internal K(+) concentration, becoming almost voltage independent in 5 mM. The K(+) sensitivity of these low- and high-affinity TEA states suggests that they may represent one- and two-ion occupancy states of the selectivity filter, consistent with recent crystallographic results from the bacterial KcsA K(+) channel. We therefore analyzed these data in terms of such a model and found a large (almost 14-fold) difference between the intrinsic TEA affinity of the one-ion and two-ion modes. According to this analysis, the single ion in the one-ion mode (at 0 mV) prefers the inner end of the selectivity filter twofold more than the outer end. This distribution does not change with internal K(+). The two ions in the two-ion mode prefer to occupy the inner end of the selectivity filter at low K(+), but high internal K(+) promotes increased occupancy of the outer sites. Our analysis further suggests that the four K(+) sites in the selectivity filter are spaced between 20 and 25% of the membrane electric field.

  13. Endoglin Selectively Modulates Transient Receptor Potential Channel Expression in Left and Right Heart Failure

    Science.gov (United States)

    Morine, Kevin J.; Paruchuri, Vikram; Qiao, Xiaoying; Aronovitz, Mark; Pham, Duc Thinh; Huggins, Gordon S.; DeNofrio, David; Kiernan, Michael S.; Karas, Richard H.; Kapur, Navin K.

    2017-01-01

    controls. In contrast to Eng+/+, PAC did not increase RV or LV levels of TRP channels in Eng +/− mice. Conclusions This is the first study to demonstrate that TRP channels exhibit distinct profiles of expression in the LV and RV of patients with heart failure and in murine models of univentricular pressure overload. We further introduce that the TGFb1 co-receptor endoglin selectively regulates expression of multiple TRP channels in the setting of LV or RV pressure overload. PMID:27614169

  14. Robust and efficient multi-frequency temporal phase unwrapping: optimal fringe frequency and pattern sequence selection.

    Science.gov (United States)

    Zhang, Minliang; Chen, Qian; Tao, Tianyang; Feng, Shijie; Hu, Yan; Li, Hui; Zuo, Chao

    2017-08-21

    Temporal phase unwrapping (TPU) is an essential algorithm in fringe projection profilometry (FPP), especially when measuring complex objects with discontinuities and isolated surfaces. Among others, the multi-frequency TPU has been proven to be the most reliable algorithm in the presence of noise. For a practical FPP system, in order to achieve an accurate, efficient, and reliable measurement, one needs to make wise choices about three key experimental parameters: the highest fringe frequency, the phase-shifting steps, and the fringe pattern sequence. However, there was very little research on how to optimize these parameters quantitatively, especially considering all three aspects from a theoretical and analytical perspective simultaneously. In this work, we propose a new scheme to determine simultaneously the optimal fringe frequency, phase-shifting steps and pattern sequence under multi-frequency TPU, robustly achieving high accuracy measurement by a minimum number of fringe frames. Firstly, noise models regarding phase-shifting algorithms as well as 3-D coordinates are established under a projector defocusing condition, which leads to the optimal highest fringe frequency for a FPP system. Then, a new concept termed frequency-to-frame ratio (FFR) that evaluates the magnitude of the contribution of each frame for TPU is defined, on which an optimal phase-shifting combination scheme is proposed. Finally, a judgment criterion is established, which can be used to judge whether the ratio between adjacent fringe frequencies is conducive to stably and efficiently unwrapping the phase. The proposed method provides a simple and effective theoretical framework to improve the accuracy, efficiency, and robustness of a practical FPP system in actual measurement conditions. The correctness of the derived models as well as the validity of the proposed schemes have been verified through extensive simulations and experiments. Based on a normal monocular 3-D FPP hardware system

  15. Space-Time-Frequency Characterization of 3D Nonisotropic MIMO Multicarrier Propagation Channels Employing Directional Antennas

    Directory of Open Access Journals (Sweden)

    Saeed Gazor

    2008-09-01

    Full Text Available Channel models for outdoor wireless systems usually assume two-dimensional (2D random scattering media. In the practical outdoor wireless channels, the impact of the wave propagation in the third-dimension is definitely important; especially when the communication system efficiently exploits potentials of multiple antennas. In this paper, we propose a new model for multiple-input multiple-output (MIMO multicarrier propagation channels in a three-dimensional (3D environment. Specifically, the proposed model describes the cross-correlation function (CCF between two subchannels of an outdoor MIMO channel employing directional antennas and in the presence of nonisotropic wave propagation in 3D space. The derived CCF consists of some correlation terms. Each correlation term is in the form of a linear series expansion of averaged Bessel functions of the first kind with different orders. In practice, each correlation term has a limited number of Bessel components. Our numerical evaluations show the impact of different parameters of the propagation environment as well as the employed antennas on the resulting CCF. Using the proposed CCF, we also establish simple formulas to approximate the coherence time, the coherence bandwidth and the spatial coherence of such channels. The numerical curve fitting results fit to the empirical results reported in the channel modeling literature.

  16. Space-Time-Frequency Characterization of 3D Nonisotropic MIMO Multicarrier Propagation Channels Employing Directional Antennas

    Directory of Open Access Journals (Sweden)

    Gazor Saeed

    2008-01-01

    Full Text Available Abstract Channel models for outdoor wireless systems usually assume two-dimensional (2D random scattering media. In the practical outdoor wireless channels, the impact of the wave propagation in the third-dimension is definitely important; especially when the communication system efficiently exploits potentials of multiple antennas. In this paper, we propose a new model for multiple-input multiple-output (MIMO multicarrier propagation channels in a three-dimensional (3D environment. Specifically, the proposed model describes the cross-correlation function (CCF between two subchannels of an outdoor MIMO channel employing directional antennas and in the presence of nonisotropic wave propagation in 3D space. The derived CCF consists of some correlation terms. Each correlation term is in the form of a linear series expansion of averaged Bessel functions of the first kind with different orders. In practice, each correlation term has a limited number of Bessel components. Our numerical evaluations show the impact of different parameters of the propagation environment as well as the employed antennas on the resulting CCF. Using the proposed CCF, we also establish simple formulas to approximate the coherence time, the coherence bandwidth and the spatial coherence of such channels. The numerical curve fitting results fit to the empirical results reported in the channel modeling literature.

  17. The frequency of drugs in randomly selected drivers in Denmark

    DEFF Research Database (Denmark)

    Simonsen, Kirsten Wiese; Steentoft, Anni; Hels, Tove

    is not included in the Danish list of narcotic drugs. Conclusion The present study gives valuable data on drugged and drunk driving. Driving under the influence constitutes a major risk in traffic and the relative high frequency of young men driving while taking drugs is worrying. Reference K.W. Simonsen, A...... stratified by time, season, and road type. The oral fluid samples were screened for 29 illegal and legal psychoactive substances and metabolites as well as ethanol. Results Fourteen (0.5%) drivers were positive for ethanol (alone or in combination with drugs) at concentrations above 0.53 g/l, which...

  18. Feature Selection and Classifier Development for Radio Frequency Device Identification

    Science.gov (United States)

    2015-12-01

    Education and Training Command In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Trevor J. Bihl, BS MS Civilian...the workings and philosophy of LVQ and the successive extensions to GRLVQ to further extend the LVQ family of algorithms. Epistemologically , LVQ...ue s 0 0.1 0.2 0.3 0.4 0.5 0.6 FrequencyPhaseAmplitude 100 [349] and has seen further application in medical [350], education data analysis [351

  19. The effect of training frequency on selected physical and ...

    African Journals Online (AJOL)

    Sixty (60) healthy but sedentary Caucasian males aged 28 – 49 years were recruited to participate in this study. They were randomly selected into 3 groups of 20 each. Groups A and B served as the training groups while group C formed the control group which remained sedentary, and followed their normal lifestyle.

  20. Frequency-dependent selection predicts patterns of radiations and biodiversity

    NARCIS (Netherlands)

    Melian, Carlos J.; Alonso, David; Vazquez, Diego P.; Regetz, James; Allesina, Stefano

    Most empirical studies support a decline in speciation rates through time, although evidence for constant speciation rates also exists. Declining rates have been explained by invoking pre-existing niches, whereas constant rates have been attributed to non-adaptive processes such as sexual selection

  1. Recent (circa 1998 to 2011) channel-migration rates of selected streams in Indiana

    Science.gov (United States)

    Robinson, Bret A.

    2013-01-01

    An investigation was completed to document recent (circa 1998 to 2011) channel-migration rates at 970 meander bends along 38 of the largest streams in Indiana. Data collection was completed by using the Google Earth™ platform and, for each selected site, identifying two images with capture dates separated by multiple years. Within each image, the position of the meander-bend cutbank was measured relative to a fixed local landscape feature visible in both images, and an average channel-migration rate was calculated at the point of maximum cutbank displacement. From these data it was determined that 65 percent of the measured sites have recently been migrating at a rate less than 1 ft/yr, 75 percent of the sites have been migrating at a rate less than 10 ft/yr, and while some sites are migrating in excess of 20 ft/yr, these occurrences are rare. In addition, it is shown that recent channel-migration activity is not evenly distributed across Indiana. For the stream reaches studied, far northern and much of far southern Indiana are drained by streams that recently have been relatively stationary. At the same time, this study shows that most of the largest streams in west-central Indiana and many of the largest streams in east-central Indiana have shown significant channel-migration activity during the recent past. It is anticipated that these results will support several fluvial-erosion-hazard mitigation activities currently being undertaken in Indiana.

  2. The frequency of drugs in randomly selected drivers in Denmark

    DEFF Research Database (Denmark)

    Simonsen, Kirsten Wiese; Steentoft, Anni; Hels, Tove

    the most frequent illicit drugs detected above the limit of quantitation (LOQ); while, codeine, tramadol, zopiclone, and benzodiazepines were the most frequent legal drugs. Middle aged men (median age 47.5 years) dominated the drunk driving group, while the drivers positive for illegal drugs consisted...... is not included in the Danish list of narcotic drugs. Conclusion The present study gives valuable data on drugged and drunk driving. Driving under the influence constitutes a major risk in traffic and the relative high frequency of young men driving while taking drugs is worrying. Reference K.W. Simonsen, A......Introduction Driving under the influence of alcohol and drugs is a global problem. In Denmark as well as in other countries there is an increasing focus on impaired driving. Little is known about the occurrence of psychoactive drugs in the general traffic. Therefore the European commission...

  3. An adaptation method to improve secret key rates of time-frequency QKD in atmospheric turbulence channels

    Science.gov (United States)

    Sun, Xiaole; Djordjevic, Ivan B.; Neifeld, Mark A.

    2016-03-01

    Free-space optical (FSO) channels can be characterized by random power fluctuations due to atmospheric turbulence, which is known as scintillation. Weak coherent source based FSO quantum key distribution (QKD) systems suffer from the scintillation effect because during the deep channel fading the expected detection rate drops, which then gives an eavesdropper opportunity to get additional information about protocol by performing photon number splitting (PNS) attack and blocking single-photon pulses without changing QBER. To overcome this problem, in this paper, we study a large-alphabet QKD protocol, which is achieved by using pulse-position modulation (PPM)-like approach that utilizes the time-frequency uncertainty relation of the weak coherent photon state, called here TF-PPM-QKD protocol. We first complete finite size analysis for TF-PPM-QKD protocol to give practical bounds against non-negligible statistical fluctuation due to finite resources in practical implementations. The impact of scintillation under strong atmospheric turbulence regime is studied then. To overcome the secure key rate performance degradation of TF-PPM-QKD caused by scintillation, we propose an adaptation method for compensating the scintillation impact. By changing source intensity according to the channel state information (CSI), obtained by classical channel, the adaptation method improves the performance of QKD system with respect to the secret key rate. The CSI of a time-varying channel can be predicted using stochastic models, such as autoregressive (AR) models. Based on the channel state predictions, we change the source intensity to the optimal value to achieve a higher secret key rate. We demonstrate that the improvement of the adaptation method is dependent on the prediction accuracy.

  4. Time-Varying FIR Equalization for MIMO Transmission over Doubly Selective Channels

    Science.gov (United States)

    Barhumi, Imad; Moonen, Marc

    2010-12-01

    We propose time-varying FIR equalization techniques for spatial multiplexing-based multiple-input multiple-output (MIMO) transmission over doubly selective channels. The doubly selective channel is approximated using the basis expansion model (BEM), and equalized by means of time-varying FIR filters designed according to the BEM. By doing so, the time-varying deconvolution problem is converted into a two-dimensional time-invariant deconvolution problem in the time-invariant coefficients of the channel BEM and the time-invariant coefficients of the equalizer BEM. The timevarying FIR equalizers are derived based on either the matched filtering criterion, or the linear minimum mean-square error (MMSE) or the zero-forcing (ZF) criteria. In addition to the linear equalizers, the decision feedback equalizer (DFE) is proposed. The DFE can be designed according to two different scenarios. In the first scenario, the DFE is based on feeding back previously estimated symbols from one particular antenna at a time. Whereas, in the second scenario, the previously estimated symbols from all transmit antennas are fed back together. The performance of the proposed equalizers in the context of MIMO transmission is analyzed in terms of numerical simulations.

  5. Time-Varying FIR Equalization for MIMO Transmission over Doubly Selective Channels

    Directory of Open Access Journals (Sweden)

    Marc Moonen

    2010-01-01

    Full Text Available We propose time-varying FIR equalization techniques for spatial multiplexing-based multiple-input multiple-output (MIMO transmission over doubly selective channels. The doubly selective channel is approximated using the basis expansion model (BEM, and equalized by means of time-varying FIR filters designed according to the BEM. By doing so, the time-varying deconvolution problem is converted into a two-dimensional time-invariant deconvolution problem in the time-invariant coefficients of the channel BEM and the time-invariant coefficients of the equalizer BEM. The timevarying FIR equalizers are derived based on either the matched filtering criterion, or the linear minimum mean-square error (MMSE or the zero-forcing (ZF criteria. In addition to the linear equalizers, the decision feedback equalizer (DFE is proposed. The DFE can be designed according to two different scenarios. In the first scenario, the DFE is based on feeding back previously estimated symbols from one particular antenna at a time. Whereas, in the second scenario, the previously estimated symbols from all transmit antennas are fed back together. The performance of the proposed equalizers in the context of MIMO transmission is analyzed in terms of numerical simulations.

  6. [Study on Sleep Staging Based on Support Vector Machines and Feature Selection in Single Channel Electroencephalogram].

    Science.gov (United States)

    Lin, Xiujing; Xia, Yongming; Qian, Songrong

    2015-06-01

    Sleep electroencephalogram (EEG) is an important index in diagnosing sleep disorders and related diseases. Manual sleep staging is time-consuming and often influenced by subjective factors. Existing automatic sleep staging methods have high complexity and a low accuracy rate. A sleep staging method based on support vector machines (SVM) and feature selection using single channel EEG single is proposed in this paper. Thirty-eight features were extracted from the single channel EEG signal. Then based on the feature selection method F-Score's definition, it was extended to multiclass with an added eliminate factor in order to find proper features, which were used as SVM classifier inputs. The eliminate factor was adopted to reduce the negative interaction of features to the result. Research on the F-Score with an added eliminate factor was further accomplished with the data from a standard open source database and the results were compared with none feature selection and standard F-Score feature selection. The results showed that the present method could effectively improve the sleep staging accuracy and reduce the computation time.

  7. Ecological genetics of the Bromus tectorum (Poaceae) - Ustilago Bullata (Ustilaginaceae): A role for frequency dependent selection?

    Science.gov (United States)

    Susan E. Meyer; David L. Nelson; Suzette Clement; Alisa Ramakrishnan

    2010-01-01

    Evolutionary processes that maintain genetic diversity in plants are likely to include selection imposed by pathogens. Negative frequency-dependent selection is a mechanism for maintenance of resistance polymorphism in plant - pathogen interactions. We explored whether such selection operates in the Bromus tectorum - Ustilago bullata pathosystem. Gene-for-gene...

  8. Energy Saving Glass Lamination via Selective Radio Frequency Heating

    Energy Technology Data Exchange (ETDEWEB)

    Shawn M. Allan; Patricia M. Strickland; Holly S. Shulman

    2009-11-11

    Ceralink Inc. developed FastFuse™, a rapid, new, energy saving process for lamination of glass and composites using radio frequency (RF) heating technology. The Inventions and Innovations program supported the technical and commercial research and development needed to elevate the innovation from bench scale to a self-supporting technology with significant potential for growth. The attached report provides an overview of the technical and commerical progress achieved for FastFuse™ during the course of the project. FastFuse™ has the potential to revolutionize the laminate manufacturing industries by replacing energy intensive, multi-step processes with an energy efficient, single-step process that allows higher throughput. FastFuse™ transmits RF energy directly into the interlayer to generate heat, eliminating the need to directly heat glass layers and the surrounding enclosures, such as autoclaves or vacuum systems. FastFuse™ offers lower start-up and energy costs (up to 90% or more reduction in energy costs), and faster cycles times (less than 5 minutes). FastFuse™ is compatible with EVA, TPU, and PVB interlayers, and has been demonstrated for glass, plastics, and multi-material structures such as photovoltaics and transparent armor.

  9. Adaptive Modulation with Best User Selection over Non-Identical Nakagami Fading Channels

    KAUST Repository

    Rao, Anlei

    2012-09-08

    In this paper, we analyze the performance of adaptive modulation with single-cell multiuser scheduling over independent but not identical distributed (i.n.i.d.) Nakagami fading channels. Closed-form expressions are derived for the average channel capacity, spectral efficiency, and bit-error-rate (BER) for both constant-power variable-rate and variable-power variable-rate uncoded M-ary quadrature amplitude modulation (M-QAM) schemes. We also study the impact of time delay on the average BER of adaptive M-QAM. Selected numerical results show that the multiuser diversity brings a considerably better performance even over i.n.i.d. fading environments.

  10. Mutational jackpot events generate effective frequency-dependent selection in adapting populations

    Science.gov (United States)

    Hallatschek, Oskar

    The site-frequency spectrum is one the most easily measurable quantities that characterize the genetic diversity of a population. While most neutral models predict that site frequency spectra should decay with increasing frequency, a high-frequency uptick has been reported in many populations. Anomalies in the high-frequency tail are particularly unsettling because the highest frequencies can be measured with greatest accuracy. Here, we show that an uptick in the spectrum of neutral mutations generally arises when mutant frequencies are dominated by rare jackpot events, mutational events with large descendant numbers. This leads to an effective pattern of frequency-dependent selection (or unstable internal equilibrium at one half frequency) that causes an accumulation of high-frequency polymorphic sites. We reproduce the known uptick occurring for recurrent hitchhiking (genetic draft) as well as rapid adaptation, and (in the future) generalize the shape of the high-frequency tail to other scenarios that are dominated by jackpot events, such as frequent range expansions. We also tackle (in the future) the inverse approach to use the high-frequency uptick for learning about the tail of the offspring number distribution. Positively selected alleles need to surpass, typically, an u NSF Career Award (PoLS), NIH NIGMS R01, Simons Foundation.

  11. Individual brain-frequency responses to self-selected music.

    Science.gov (United States)

    Höller, Yvonne; Thomschewski, Aljoscha; Schmid, Elisabeth Verena; Höller, Peter; Crone, Julia Sophia; Trinka, Eugen

    2012-12-01

    Music is a stimulus which may give rise to a wide range of emotional and cognitive responses. Therefore, brain reactivity to music has become a focus of interest in cognitive neuroscience. It is possible that individual preference moderates the effectof music on the brain. In the present study we examined whether there are common effects of listening to music even if each subject in a sample chooses their own piece of music. We invited 18 subjects to bring along their favorite relaxing music, and their favourite stimulating music. Additionally, a condition with tactile stimulation on the foot and a baseline condition (rest) without stimulation were used. The tactile stimulation was chosen to provide a simple, non-auditory condition which would be identical for all subjects. The electroencephalogram was recorded for each of the 3 conditions and during rest. We found responses in the alpha range mainly on parietal and occipital sites that were significant compared to baseline in 13 subjects during relaxing music, 15 subjects during activating music, and 16 subjects during tactile stimulation. Most subjects showed an alpha desynchronization in a lower alpha range followed by a synchronization in an upper frequency range. However, some subjects showed an increase in this area, whereas others showed a decrease only. In addition, many subjects showed reactivity in the beta range. Beta activity was especially increased while listening to activating music and during tactile stimulation in most subjects. We found interindividual differences in the response patterns even though the stimuli provoked comparable subjective emotions (relaxation, activation), and even if the stimulus was the same for all subjects (somatosensory stimulation). We suggest that brain responsivity to music should be examined individually by considering individual characteristics. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. Energy Saving Glass Lamination via Selective Radio-Frequency Heating

    Energy Technology Data Exchange (ETDEWEB)

    Shulman, Holly S.; Allan, Shawn M.

    2009-11-11

    This Inventions and Innovations program supported the technical and commercial research and development needed to elevate Ceralink's energy saving process for flat glass lamination from bench scale to a self-supporting technology with significant potential for growth. Radio-frequency heating was any un-explored option for laminating glass prior to this program. With significant commercial success through time and energy savings in the wood, paper, and plastics industries, RF heating was found to have significant promise for the energy intensive glass lamination industry. A major technical goal of the program was to demonstrate RF lamination across a wide range of laminate sizes and materials. This was successfully accomplished, dispelling many skeptics' concerns about the abilities of the technology. Ceralink laminated panels up to 2 ft x 3 ft, with four sets processed simultaneously, in a 3 minute cycle. All major categories of interlayer materials were found to work with RF lamination. In addition to laminating glass, other materials including photovoltaic silicon solar cells, light emitting diodes, metallized glass, plastics (acrylic and polycarbonate), and ceramics (alumina) were found compatible with the RF process. This opens up a wide range of commercial opportunities beyond the initially targeted automotive industry. The dramatic energy savings reported for RF lamination at the bench scale were found to be maintained through the scale up of the process. Even at 2 ft x 3 ft panel sizes, energy savings are estimated to be at least 90% compared to autoclaving or vacuum lamination. With targeted promotion through conference presentations, press releases and internet presence, RF lamination has gained significant attention, drawing large audiences at American Ceramic Society meetings. The commercialization success of the project includes the establishment of a revenue-generating business model for providing process development and demonstrations for

  13. From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group

    DEFF Research Database (Denmark)

    Blom, Sigrid Marie; Rottländer, Mario; Kehler, Jan

    2014-01-01

    .2-5 opener retigabine indicate that SMB-1 binds within the same pocket as retigabine for both inhibition of KV7.2 and activation of KV7.4. SMB-1 may serve as a valuable tool for KV7 channel research and may be used as a template for further design of better subtype selective KV7 channel modulators...

  14. MHC allele frequency distributions under parasite-driven selection: A simulation model

    Directory of Open Access Journals (Sweden)

    Radwan Jacek

    2010-10-01

    Full Text Available Abstract Background The extreme polymorphism that is observed in major histocompatibility complex (MHC genes, which code for proteins involved in recognition of non-self oligopeptides, is thought to result from a pressure exerted by parasites because parasite antigens are more likely to be recognized by MHC heterozygotes (heterozygote advantage and/or by rare MHC alleles (negative frequency-dependent selection. The Ewens-Watterson test (EW is often used to detect selection acting on MHC genes over the recent history of a population. EW is based on the expectation that allele frequencies under balancing selection should be more even than under neutrality. We used computer simulations to investigate whether this expectation holds for selection exerted by parasites on host MHC genes under conditions of heterozygote advantage and negative frequency-dependent selection acting either simultaneously or separately. Results In agreement with simple models of symmetrical overdominance, we found that heterozygote advantage acting alone in populations does, indeed, result in more even allele frequency distributions than expected under neutrality, and this is easily detectable by EW. However, under negative frequency-dependent selection, or under the joint action of negative frequency-dependent selection and heterozygote advantage, distributions of allele frequencies were less predictable: the majority of distributions were indistinguishable from neutral expectations, while the remaining runs resulted in either more even or more skewed distributions than under neutrality. Conclusions Our results indicate that, as long as negative frequency-dependent selection is an important force maintaining MHC variation, the EW test has limited utility in detecting selection acting on these genes.

  15. Multisource full waveform inversion of marine streamer data with frequency selection

    KAUST Repository

    Huang, Yunsong

    2013-01-01

    Multisource migration with frequency selection is now extended to multisource full waveform inversion (FWI) of supergathers for marine streamer data. There are three advantages of this approach compared to conventional FWI for marine streamer data. 1. The multisource FWI method with frequency selection is computationally more efficient than conventional FWI. 2. A supergather requires more than an order of magnitude less storage than the the original data. 3. Frequency selection overcomes the acquisition mismatch between the observed data and the simulated multisource supergathers for marine data. This mismatch problem has prevented the efficient application of FWI to marine geometries in the space-time domain. Preliminary result of applying multisource FWI with frequency selection to a synthetic marine data set suggests it is at least four times more efficient than standard FWI.

  16. 47 CFR 90.315 - Special provisions governing use of frequencies in the 476-494 MHz band (TV Channels 15, 16, 17...

    Science.gov (United States)

    2010-10-01

    ... in the 476-494 MHz band (TV Channels 15, 16, 17) in the Southern Louisiana-Texas Offshore Zone. 90... RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Authorization in the Band 470-512 MHz (UHF-TV Sharing) § 90.315 Special provisions governing use of frequencies in the 476-494 MHz band (TV Channels 15, 16...

  17. Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels.

    Directory of Open Access Journals (Sweden)

    Rene Raphemot

    Full Text Available Vector-borne diseases such as dengue fever and malaria, which are transmitted by infected female mosquitoes, affect nearly half of the world's population. The emergence of insecticide-resistant mosquito populations is reducing the effectiveness of conventional insecticides and threatening current vector control strategies, which has created an urgent need to identify new molecular targets against which novel classes of insecticides can be developed. We previously demonstrated that small molecule inhibitors of mammalian Kir channels represent promising chemicals for new mosquitocide development. In this study, high-throughput screening of approximately 30,000 chemically diverse small-molecules was employed to discover potent and selective inhibitors of Aedes aegypti Kir1 (AeKir1 channels heterologously expressed in HEK293 cells. Of 283 confirmed screening 'hits', the small-molecule inhibitor VU625 was selected for lead optimization and in vivo studies based on its potency and selectivity toward AeKir1, and tractability for medicinal chemistry. In patch clamp electrophysiology experiments of HEK293 cells, VU625 inhibits AeKir1 with an IC50 value of 96.8 nM, making VU625 the most potent inhibitor of AeKir1 described to date. Furthermore, electrophysiology experiments in Xenopus oocytes revealed that VU625 is a weak inhibitor of AeKir2B. Surprisingly, injection of VU625 failed to elicit significant effects on mosquito behavior, urine excretion, or survival. However, when co-injected with probenecid, VU625 inhibited the excretory capacity of mosquitoes and was toxic, suggesting that the compound is a substrate of organic anion and/or ATP-binding cassette (ABC transporters. The dose-toxicity relationship of VU625 (when co-injected with probenecid is biphasic, which is consistent with the molecule inhibiting both AeKir1 and AeKir2B with different potencies. This study demonstrates proof-of-concept that potent and highly selective inhibitors of mosquito

  18. Low-Frequency Damping Behavior of Pure MG Processed by Equal Channel Angular Pressing

    Science.gov (United States)

    Fan, G. D.; Zheng, M. Y.; Hu, X. S.; Chang, H.; Wu, K.

    Equal channel angular pressing (ECAP) was performed on the extruded pure magnesium at 250°C for 4 passes. After ECAP processing, the grain size was significantly refined. And the damping capacity was increased at low strain amplitudes, but decreased at high strain amplitudes. Three peaks were observed during the measurement of damping capacity at elevated temperatures. The mechanisms for damping capacity of pure Mg at ambient and elevated temperatures were discussed.

  19. Monitoring Voltage-Dependent Charge Displacement of Shaker B-IR K+ Ion Channels Using Radio Frequency Interrogation

    OpenAIRE

    Dharia, Sameera; Rabbitt, Richard D.

    2011-01-01

    Here we introduce a new technique that probes voltage-dependent charge displacements of excitable membrane-bound proteins using extracellularly applied radio frequency (RF, 500 kHz) electric fields. Xenopus oocytes were used as a model cell for these experiments, and were injected with cRNA encoding Shaker B-IR (ShB-IR) K(+) ion channels to express large densities of this protein in the oocyte membranes. Two-electrode voltage clamp (TEVC) was applied to command whole-cell membrane potential a...

  20. Frequency-Selective Surface to Prevent Interference Between Radar and SATCOM Antennas

    NARCIS (Netherlands)

    Monni, S.; Neto, A.; Gerini, G.; Nennie, F.; Tijhuis, A.

    2009-01-01

    Interference between neighboring antennas operating in nearby frequency ranges can lead to damage of the front-end electronics. This letter presents the design of a frequency-selective surface (FSS) aimed at preventing the saturation of the low noise amplifiers of a phased-array radar antenna due to

  1. Energy Saving Glass Lamination via Selective Radio Frequency Heating

    Energy Technology Data Exchange (ETDEWEB)

    Allan, Shawn M.

    2012-02-27

    This project focused on advancing radio-frequency (RF) lamination technology closer to commercial implementation, in order to reduce the energy intensity of glass lamination by up to 90%. Lamination comprises a wide range of products including autoglass, architectural safety and innovative design glass, transparent armor (e.g. bullet proof glass), smart glass, mirrors, and encapsulation of photovoltaics. Lamination is also the fastest growing segment of glass manufacturing, with photovoltaics, architectural needs, and an anticipated transition to laminated side windows in vehicles. The state-of-the-art for glass lamination is to use autoclaves, which apply heat and uniform gas pressure to bond the laminates over the course of 1 to 18 hours. Laminates consist of layers of glass or other materials bonded with vinyl or urethane interlayers. In autoclaving, significant heat energy is lost heating the chamber, pressurized air, glass racks, and the glass. In RF lamination, the heat is generated directly in the vinyl interlayer, causing it to heat and melt quickly, in just 1 to 10 minutes, without significantly heating the glass or the equipment. The main purpose of this project was to provide evidence that low energy, rapid RF lamination quality met the same standards as conventionally autoclaved windows. The development of concepts for laminating curved glass with RF lamination was a major goal. Other primary goals included developing a stronger understanding of the lamination product markets described above, and to refine the potential benefits of commercial implementation. The scope of the project was to complete implementation concept studies in preparation for continuation into advanced development, pilot studies, and commercial implementation. The project consisted of 6 main tasks. The first dealt with lamination with poly-vinyl butyral (PVB) interlayers, which prior work had shown difficulties in achieving good quality laminates, working with Pilkington North

  2. Energy Saving Glass Lamination via Selective Radio Frequency Heating

    Energy Technology Data Exchange (ETDEWEB)

    Allan, Shawn M; Baranova, Inessa; Poley, Joseph; Reis, Henrique

    2012-02-27

    This project focused on advancing radio-frequency (RF) lamination technology closer to commercial implementation, in order to reduce the energy intensity of glass lamination by up to 90%. Lamination comprises a wide range of products including autoglass, architectural safety and innovative design glass, transparent armor (e.g. bullet proof glass), smart glass, mirrors, and encapsulation of photovoltaics. Lamination is also the fastest growing segment of glass manufacturing, with photovoltaics, architectural needs, and an anticipated transition to laminated side windows in vehicles. The state-of-the-art for glass lamination is to use autoclaves, which apply heat and uniform gas pressure to bond the laminates over the course of 1 to 18 hours. Laminates consist of layers of glass or other materials bonded with vinyl or urethane interlayers. In autoclaving, significant heat energy is lost heating the chamber, pressurized air, glass racks, and the glass. In RF lamination, the heat is generated directly in the vinyl interlayer, causing it to heat and melt quickly, in just 1 to 10 minutes, without significantly heating the glass or the equipment. The main purpose of this project was to provide evidence that low energy, rapid RF lamination quality met the same standards as conventionally autoclaved windows. The development of concepts for laminating curved glass with RF lamination was a major goal. Other primary goals included developing a stronger understanding of the lamination product markets described above, and to refine the potential benefits of commercial implementation. The scope of the project was to complete implementation concept studies in preparation for continuation into advanced development, pilot studies, and commercial implementation. The project consisted of 6 main tasks. The first dealt with lamination with poly-vinyl butyral (PVB) interlayers, which prior work had shown difficulties in achieving good quality laminates, working with Pilkington North

  3. Full Waveform Inversion with Multisource Frequency Selection of Marine Streamer Data

    KAUST Repository

    Huang, Yunsong

    2017-10-27

    The theory and practice of multisource full waveform inversion of marine supergathers are described with a frequency-selection strategy. The key enabling property of frequency selection is that it eliminates the crosstalk among sources, thus overcoming the aperture mismatch of marine multisource inversion. Tests on multisource full waveform inversion of synthetic marine data and Gulf of Mexico data show speedups of 4× and 8×, respectively, compared to conventional full waveform inversion.

  4. Recombinant Expression and Functional Characterization of Martentoxin: A Selective Inhibitor for BK Channel (α + β4

    Directory of Open Access Journals (Sweden)

    Jie Tao

    2014-04-01

    Full Text Available Martentoxin (MarTX, a 37-residue peptide purified from the venom of East-Asian scorpion (Buthus martensi Karsch, was capable of blocking large-conductance Ca2+-activated K+ (BK channels. Here, we report an effective expression and purification approach for this toxin. The cDNA encoding martentoxin was expressed by the prokaryotic expression system pGEX-4T-3 which was added an enterokinase cleavage site by PCR. The fusion protein (GST-rMarTX was digested by enterokinase to release hetero-expressed toxin and further purified via reverse-phase HPLC. The molecular weight of the hetero-expressed rMarTX was 4059.06 Da, which is identical to that of the natural peptide isolated from scorpion venom. Functional characterization through whole-cell patch clamp showed that rMarTX selectively and potently inhibited the currents of neuronal BK channels (α + β4 (IC50 = 186 nM, partly inhibited mKv1.3, but hardly having any significant effect on hKv4.2 and hKv3.1a even at 10 μM. Successful expression of martentoxin lays basis for further studies of structure-function relationship underlying martentoxin or other potassium-channel specific blockers.

  5. Alpha-helical hydrophobic polypeptides form proton-selective channels in lipid bilayers

    Science.gov (United States)

    Oliver, A. E.; Deamer, D. W.

    1994-01-01

    Proton translocation is important in membrane-mediated processes such as ATP-dependent proton pumps, ATP synthesis, bacteriorhodopsin, and cytochrome oxidase function. The fundamental mechanism, however, is poorly understood. To test the theoretical possibility that bundles of hydrophobic alpha-helices could provide a low energy pathway for ion translocation through the lipid bilayer, polyamino acids were incorporated into extruded liposomes and planar lipid membranes, and proton translocation was measured. Liposomes with incorporated long-chain poly-L-alanine or poly-L-leucine were found to have proton permeability coefficients 5 to 7 times greater than control liposomes, whereas short-chain polyamino acids had relatively little effect. Potassium permeability was not increased markedly by any of the polyamino acids tested. Analytical thin layer chromatography measurements of lipid content and a fluorescamine assay for amino acids showed that there were approximately 135 polyleucine or 65 polyalanine molecules associated with each liposome. Fourier transform infrared spectroscopy indicated that a major fraction of the long-chain hydrophobic peptides existed in an alpha-helical conformation. Single-channel recording in both 0.1 N HCl and 0.1 M KCl was also used to determine whether proton-conducting channels formed in planar lipid membranes (phosphatidylcholine/phosphatidylethanolamine, 1:1). Poly-L-leucine and poly-L-alanine in HCl caused a 10- to 30-fold increase in frequency of conductive events compared to that seen in KCl or by the other polyamino acids in either solution. This finding correlates well with the liposome observations in which these two polyamino acids caused the largest increase in membrane proton permeability but had little effect on potassium permeability. Poly-L-leucine was considerably more conductive than poly-L-alanine due primarily to larger event amplitudes and, to a lesser extent, a higher event frequency. Poly-L-leucine caused two

  6. Selectivity problems with drugs acting on cardiac Na⁺ and Ca²⁺ channels.

    Science.gov (United States)

    Hegyi, Bence; Komáromi, István; Nánási, Péter P; Szentandrássy, Norbert

    2013-01-01

    With the increase of our knowledge on cardioactive agents it comes more and more clear that practically none of the currently used compounds shows absolute selectivity to one or another ion channel type. This is particularly true for Na(+) and Ca(2+) channel modulators, which are widely applied in the clinical practice and biomedical research. The best example might be probably the marine guanidine poison tetrodotoxin, which has long been considered as a selective Na(+) channel blocker, while recently it turned out to effectively inhibit cardiac Ca(2+) currents as well. In the present study the cross actions observed between the effects of various blockers of Na(+) channels (such as toxin inhibitors, class I antiarrhythmics and local anesthetics) and Ca(2+) channels (like phenylalkylamines, dihydropyridine compounds, diltiazem and mibefradil) are overviewed in light of the known details of the respective channel structures. Similarly, activators of Na(+) channels, including veratridine and batrachotoxin, are also compared. The binding of tetrodotoxin and saxitoxin to Cav1.2 and Nav1.5 channel proteins is presented by construction of theoretical models to reveal common structures in their pore forming regions to explain cross reactions. Since these four domain channels can be traced back to a common ancestor, a close similarity in their structure can well be demonstrated. Thus, the poor selectivity of agents acting on cardiac Na(+) and Ca(2+) channels is a consequence of evolution. As a conclusion, since the limited selectivity is an intrinsic property of drug receptors, it has to be taken into account when designing new cardioactive compounds for either medical therapy or experimental research in the future.

  7. Wi-Fi Influence on LTE-U Downlink Data and Control Channel Performance in Shared Frequency Bands

    Directory of Open Access Journals (Sweden)

    J. Milos

    2017-04-01

    Full Text Available Nowadays, providers of wireless services try to find appropriate ways to increase user data throughput mainly for future 5G cellular networks. Utilizing the unlicensed spectrum (ISM bands for such purpose is a promising solution: unlicensed frequency bands can be used as a complementary data pipeline for UMTS LTE (Universal Mobile Telecommunication System - Long Term Evolution and its advanced version LTE-Advanced, especially in pico- or femtocells. However, coexisting LTE and WLAN services in shared ISM bands at the same time can suffer unwanted performance degradation. This paper focuses predominantly on co-channel coexistence issues (worst case between LTE and WLAN (IEEE 802.11n services in the ISM band. From the viewpoint of novelty, the main outcomes of this article are follows. Firstly, an appropriate signal processing approach for coexisting signals with different features in the baseband is proposed. It is applied in advanced link-layer simulators and its correctness is verified by various simulations. Secondly, the influence of IEEE 802.11n on LTE data and control channel performance is explored. Performance evaluation is based on error rate curves, depending on Signal-to-Interference ratio (SIR. Presented results allow for better understanding the influence of IEEE 802.11n on the LTE downlink physical control channels (PCCH and are valuable for mobile infrastructure vendors and operators to optimize system parameters.

  8. Broadband Mm-Wave OFDM Communications in Doubly Selective Channel: Performance Evaluation Using Measured Mm-Wave Channel

    DEFF Research Database (Denmark)

    Chen, Xiaoming; Fan, Wei; Pedersen, Gert F.

    2018-01-01

    coefficients of the broadband mm-wave channel do not follow Gaussian distribution due to the broad bandwidth. It is also shown that, given a cyclic prefix (CP) length for a certain delay spread, an effective PN mitigation scheme enables a PN corrupted OFDM system to function with small subcarrier spacing and......In this work, we evaluate the performance of the broadband millimeter-wave (mm-wave) OFDM system in the presence of phase noise (PN) of phase-locked loop based oscillator and delay spread of measured mm-wave channel. It is shown, using Akaike's information criterion, that the channel tap......, therefore, small CP overhead, with only slight degradation of the error rate performance....

  9. Cryocooled wideband digital channelizing radio-frequency receiver based on low-pass ADC

    International Nuclear Information System (INIS)

    Vernik, Igor V; Kirichenko, Dmitri E; Dotsenko, Vladimir V; Miller, Robert; Webber, Robert J; Shevchenko, Pavel; Talalaevskii, Andrei; Gupta, Deepnarayan; Mukhanov, Oleg A

    2007-01-01

    We have demonstrated a digital receiver performing direct digitization of radio-frequency signals over a wide frequency range from kilohertz to gigahertz. The complete system, consisting of a cryopackaged superconductor all-digital receiver (ADR) chip followed by room-temperature interface electronics and a field programmable gate array (FPGA) based post-processing module, has been developed. The ADR chip comprises a low-pass analog-to-digital converter (ADC) delta modulator with phase modulation-demodulation architecture together with digital in-phase and quadrature mixer and a pair of digital decimation filters. The chip is fabricated using a 4.5 kA cm -2 process and is cryopackaged using a commercial-off-the-shelf cryocooler. Experimental results in HF, VHF, UHF and L bands and their analysis, proving consistent operation of the cryopackaged ADR chip up to 24.32 GHz clock frequency, are presented and discussed

  10. A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels.

    Science.gov (United States)

    Napolitano, Luisa Maria Rosaria; Bisha, Ina; De March, Matteo; Marchesi, Arin; Arcangeletti, Manuel; Demitri, Nicola; Mazzolini, Monica; Rodriguez, Alex; Magistrato, Alessandra; Onesti, Silvia; Laio, Alessandro; Torre, Vincent

    2015-07-07

    Cyclic nucleotide-gated (CNG) ion channels, despite a significant homology with the highly selective K(+) channels, do not discriminate among monovalent alkali cations and are permeable also to several organic cations. We combined electrophysiology, molecular dynamics (MD) simulations, and X-ray crystallography to demonstrate that the pore of CNG channels is highly flexible. When a CNG mimic is crystallized in the presence of a variety of monovalent cations, including Na(+), Cs(+), and dimethylammonium (DMA(+)), the side chain of Glu66 in the selectivity filter shows multiple conformations and the diameter of the pore changes significantly. MD simulations indicate that Glu66 and the prolines in the outer vestibule undergo large fluctuations, which are modulated by the ionic species and the voltage. This flexibility underlies the coupling between gating and permeation and the poor ionic selectivity of CNG channels.

  11. Transmit selection algorithms for imperfect threshold-based receive MRC in the presence of co-channel interference

    KAUST Repository

    Radaydeh, Redha Mahmoud Mesleh

    2010-01-01

    The performance of transmit antenna selection for threshold-based maximal ratio combining (MRC) diversity receivers in the presence of multiple co-channel interfering signals is studied. The impact of imperfect channel estimation of desired user signals is considered, and the effect of phase and time misalignments between desired and undesired signals is incorporated in the analysis. Precise formulation for Nakagami-m faded interfering signals is presented. The analysis is applicable for arbitrary transmit antenna selection, which is based on the receiver combined signal-to-noise ratios (SNRs) or combined signal-to-interference-plus-noise ratios (SINRs) for different transmit channels. New expressions for the distribution of combined SINR and outage probability performance are derived considering SNR-based as well as SINR-based selection algorithms. The results can be used to study the performance of different system architectures under various channel conditions when the implementation complexity is of interest. ©2010 IEEE.

  12. Low-frequency 1/f noise in MoS2 transistors: Relative contributions of the channel and contacts

    International Nuclear Information System (INIS)

    Renteria, J.; Jiang, C.; Samnakay, R.; Rumyantsev, S. L.; Goli, P.; Balandin, A. A.; Shur, M. S.

    2014-01-01

    We report on the results of the low-frequency (1/f, where f is frequency) noise measurements in MoS 2 field-effect transistors revealing the relative contributions of the MoS 2 channel and Ti/Au contacts to the overall noise level. The investigation of the 1/f noise was performed for both as fabricated and aged transistors. It was established that the McWhorter model of the carrier number fluctuations describes well the 1/f noise in MoS 2 transistors, in contrast to what is observed in graphene devices. The trap densities extracted from the 1/f noise data for MoS 2 transistors, are 2 × 10 19  eV −1 cm −3 and 2.5 × 10 20  eV −1 cm −3 for the as fabricated and aged devices, respectively. It was found that the increase in the noise level of the aged MoS 2 transistors is due to the channel rather than the contact degradation. The obtained results are important for the proposed electronic applications of MoS 2 and other van der Waals materials

  13. Low-frequency 1/f noise in MoS{sub 2} transistors: Relative contributions of the channel and contacts

    Energy Technology Data Exchange (ETDEWEB)

    Renteria, J.; Jiang, C. [Nano-Device Laboratory, Department of Electrical Engineering, Bourns College of Engineering, University of California – Riverside, Riverside, California 92521 (United States); Samnakay, R. [Materials Science and Engineering Program, Bourns College of Engineering, University of California – Riverside, Riverside, California 92521 (United States); Rumyantsev, S. L. [Department of Electrical, Computer, and Systems Engineering, Center for Integrated Electronics, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States); Ioffe Physical-Technical Institute, St. Petersburg 194021 (Russian Federation); Goli, P.; Balandin, A. A., E-mail: balandin@ee.ucr.edu [Nano-Device Laboratory, Department of Electrical Engineering, Bourns College of Engineering, University of California – Riverside, Riverside, California 92521 (United States); Materials Science and Engineering Program, Bourns College of Engineering, University of California – Riverside, Riverside, California 92521 (United States); Shur, M. S. [Department of Electrical, Computer, and Systems Engineering, Center for Integrated Electronics, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States)

    2014-04-14

    We report on the results of the low-frequency (1/f, where f is frequency) noise measurements in MoS{sub 2} field-effect transistors revealing the relative contributions of the MoS{sub 2} channel and Ti/Au contacts to the overall noise level. The investigation of the 1/f noise was performed for both as fabricated and aged transistors. It was established that the McWhorter model of the carrier number fluctuations describes well the 1/f noise in MoS{sub 2} transistors, in contrast to what is observed in graphene devices. The trap densities extracted from the 1/f noise data for MoS{sub 2} transistors, are 2 × 10{sup 19} eV{sup −1}cm{sup −3} and 2.5 × 10{sup 20} eV{sup −1}cm{sup −3} for the as fabricated and aged devices, respectively. It was found that the increase in the noise level of the aged MoS{sub 2} transistors is due to the channel rather than the contact degradation. The obtained results are important for the proposed electronic applications of MoS{sub 2} and other van der Waals materials.

  14. Low-frequency 1/f noise in MoS2 transistors: Relative contributions of the channel and contacts

    Science.gov (United States)

    Renteria, J.; Samnakay, R.; Rumyantsev, S. L.; Jiang, C.; Goli, P.; Shur, M. S.; Balandin, A. A.

    2014-04-01

    We report on the results of the low-frequency (1/f, where f is frequency) noise measurements in MoS2 field-effect transistors revealing the relative contributions of the MoS2 channel and Ti/Au contacts to the overall noise level. The investigation of the 1/f noise was performed for both as fabricated and aged transistors. It was established that the McWhorter model of the carrier number fluctuations describes well the 1/f noise in MoS2 transistors, in contrast to what is observed in graphene devices. The trap densities extracted from the 1/f noise data for MoS2 transistors, are 2 × 1019 eV-1cm-3 and 2.5 × 1020 eV-1cm-3 for the as fabricated and aged devices, respectively. It was found that the increase in the noise level of the aged MoS2 transistors is due to the channel rather than the contact degradation. The obtained results are important for the proposed electronic applications of MoS2 and other van der Waals materials.

  15. Effect of oscillation frequency on wall shear stress and pressure drop in a rectangular channel for heat transfer applications

    International Nuclear Information System (INIS)

    Blythman, R; Persoons, T; Murray, DB; Jeffers, N

    2016-01-01

    The exploitation of flow unsteadiness in microchannels is a potentially useful technique for enhancing cooling of future photonics systems. Pulsation is thought to alter the thickness of the hydrodynamic and thermal boundary layers, and hence affect the overall thermal resistance of the heat sink. While the mechanical and thermal problems are inextricably linked, it is useful to decouple the parameters to better understand the mechanisms underlying any heat transfer enhancement. The current work characterises the behaviour of the wall shear stress and pressure gradient with frequency, using experimental particle image velocimetry (PIV) measurements and the analytical solution for oscillatory flow in a two-dimensional rectangular channel. Both wall shear stress and pressure gradient are augmented with frequency compared to steady flow, though the pressure gradient increases more significantly as a result of growing inertial losses. The three distinct regimes of unsteadiness are shown to display unique relationships between the parameters pertinent to heat transfer and should therefore be considered independently with respect to thermal enhancement capability. To this end, the regime boundaries are estimated at Womersley number Wo = 1.6 and 28.4 in a rectangular channel, based on the contribution of viscous and inertial losses. (paper)

  16. Relations between frequency selectivity, temporal fine-structure processing, and speech reception in impaired hearing

    DEFF Research Database (Denmark)

    Strelcyk, Olaf; Dau, Torsten

    2009-01-01

    Frequency selectivity, temporal fine-structure (TFS) processing, and speech reception were assessed for six normal-hearing (NH) listeners, ten sensorineurally hearing-impaired (HI) listeners with similar high-frequency losses, and two listeners with an obscure dysfunction (OD). TFS processing...... was investigated at low frequencies in regions of normal hearing, through measurements of binaural masked detection, tone lateralization, and monaural frequency modulation (FM) detection. Lateralization and FM detection thresholds were measured in quiet and in background noise. Speech reception thresholds were...... in a two-talker background and lateralized noise, but not in amplitude-modulated noise. The results provide constraints for future models of impaired auditory signal processing....

  17. Efficient and Robust Detection of GFSK Signals under Dispersive Channel, Modulation Index, and Carrier Frequency Offset Conditions

    Directory of Open Access Journals (Sweden)

    Stephan Weiss

    2005-09-01

    Full Text Available Gaussian frequency shift keying is the modulation scheme specified for Bluetooth. Signal adversities typical in Bluetooth networks include AWGN, multipath propagation, carrier frequency, and modulation index offsets. In our effort to realise a robust but efficient Bluetooth receiver, we adopt a high-performance matched-filter-based detector, which is near optimal in AWGN, but requires a prohibitively costly filter bank for processing of K bits worth of the received signal. However, through filtering over a single bit period and performing phase propagation of intermediate results over successive single-bit stages, we eliminate redundancy involved in providing the matched filter outputs and reduce its complexity by up to 90% (for K=9. The constant modulus signal characteristic and the potential for carrier frequency offsets make the constant modulus algorithm (CMA suitable for channel equalisation, and we demonstrate its effectiveness in this paper. We also introduce a stochastic gradient-based algorithm for carrier frequency offset correction, and show that the relative rotation between successive intermediate filter outputs enables us to detect and correct offsets in modulation index.

  18. Broadband Mm-Wave OFDM Communications in Doubly Selective Channel: Performance Evaluation Using Measured Mm-Wave Channel

    DEFF Research Database (Denmark)

    Chen, Xiaoming; Fan, Wei; Pedersen, Gert F.

    2018-01-01

    coefficients of the broadband mm-wave channel do not follow Gaussian distribution due to the broad bandwidth. It is also shown that, given a cyclic prefix (CP) length for a certain delay spread, an effective PN mitigation scheme enables a PN corrupted OFDM system to function with small subcarrier spacing and...

  19. A De Novo Mutation in the Sodium-Activated Potassium Channel KCNT2 Alters Ion Selectivity and Causes Epileptic Encephalopathy

    Directory of Open Access Journals (Sweden)

    Sushmitha Gururaj

    2017-10-01

    Full Text Available Early infantile epileptic encephalopathies (EOEE are a debilitating spectrum of disorders associated with cognitive impairments. We present a clinical report of a KCNT2 mutation in an EOEE patient. The de novo heterozygous variant Phe240Leu SLICK was identified by exome sequencing and confirmed by Sanger sequencing. Phe240Leu rSlick and hSLICK channels were electrophysiologically, heterologously characterized to reveal three significant alterations to channel function. First, [Cl−]i sensitivity was reversed in Phe240Leu channels. Second, predominantly K+-selective WT channels were made to favor Na+ over K+ by Phe240Leu. Third, and consequent to altered ion selectivity, Phe240Leu channels had larger inward conductance. Further, rSlick channels induced membrane hyperexcitability when expressed in primary neurons, resembling the cellular seizure phenotype. Taken together, our results confirm that Phe240Leu is a “change-of-function” KCNT2 mutation, demonstrating unusual altered selectivity in KNa channels. These findings establish pathogenicity of the Phe240Leu KCNT2 mutation in the reported EOEE patient.

  20. CHANGING FLOOD FREQUENCY IN SCOTLAND: IMPLICATIONS FOR CHANNEL GEOMORPHOLOGY, ECOLOGY AND MANAGEMENT

    OpenAIRE

    Thompson, Fiona Hilary

    2017-01-01

    The effect of climate on the fluvial system has long been investigated due the significant impact it can have on a river’s hydrological regime and fluvial processes. In recent years this interest has increased as global changes in climate are expected to bring more frequent high magnitude flood events globally and to North West Europe in particular. Despite the knowledge that the frequency and magnitude of floods is to increase, less is known about the geomorphological implicat...

  1. DFT-based channel estimation and noise variance estimation techniques for single-carrier FDMA

    OpenAIRE

    Huang, G; Nix, AR; Armour, SMD

    2010-01-01

    Practical frequency domain equalization (FDE) systems generally require knowledge of the channel and the noise variance to equalize the received signal in a frequency-selective fading channel. Accurate channel estimate and noise variance estimate are thus desirable to improve receiver performance. In this paper we investigate the performance of the denoise channel estimator and the approximate linear minimum mean square error (A-LMMSE) channel estimator with channel power delay profile (PDP) ...

  2. Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting.

    Science.gov (United States)

    Fukuda, A; Takemoto, M; Saito, T; Fujibayashi, S; Neo, M; Pattanayak, Deepak K; Matsushita, T; Sasaki, K; Nishida, N; Kokubo, T; Nakamura, T

    2011-05-01

    Many studies have shown that certain biomaterials with specific porous structures can induce bone formation in non-osseous sites without the need for osteoinductive biomolecules, however, the mechanisms responsible for this phenomenon (intrinsic osteoinduction of biomaterials) remain unclear. In particular, to our knowledge the type of pore structure suitable for osteoinduction has not been reported in detail. In the present study we investigated the effects of interconnective pore size on osteoinductivity and the bone formation processes during osteoinduction. Selective laser melting was employed to fabricate porous Ti implants (diameter 3.3mm, length 15 mm) with a channel structure comprising four longitudinal square channels, representing pores, of different diagonal widths, 500, 600, 900, and 1200 μm (termed p500, p600, p900, and p1200, respectively). These were then subjected to chemical and heat treatments to induce bioactivity. Significant osteoinduction was observed in p500 and p600, with the highest observed osteoinduction occurring at 5mm from the end of the implants. A distance of 5mm probably provides a favorable balance between blood circulation and fluid movement. Thus, the simple architecture of the implants allowed effective investigation of the influence of the interconnective pore size on osteoinduction, as well as the relationship between bone quantity and its location for different pore sizes. Copyright © 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  3. Performance of a Cognitive Relay Network under AF Relay Selection Scheme with Imperfect Channel Estimation

    Directory of Open Access Journals (Sweden)

    B. Prasad

    2016-06-01

    Full Text Available In this paper outage performance of a secondary user (SU is evaluated under amplify and forward (AF relay selection scheme with an imperfect channel state information (CSIwhile sharing spectrum in an underlay cognitive radio network (CRN. In underlay, the SU coexists with primary user (PU in the same band provided the interference produced by SU at the PU receiver is below the interference threshold of PU which limits the transmission power of SU and coverage area. Relays help to improve the performance of SU in underlay. However relays are also constrained in transmit power due to interference constraint imposed by PU. Closed form expression of the outage probability of SU with maximum transmit power constraint of relay under imperfect CSI is derived. A scaling factor based power control is used for the SU transmitter and the relay in order to maintain the interference constraint at PU receiver due to imperfect CSI. The impact of different parameters viz. correlation coefficient, channel estimation error, tolerable interference threshold, number of relays and the maximum transmit power constraint of relay on SU performance is investigated. A MATLAB based test bed has also been developed to carry out simulation in order to validate the theoretical result.

  4. Selective trapping and concentration of nanoparticles and viruses in dual-height nanofluidic channels.

    Science.gov (United States)

    Hamblin, Mark N; Xuan, Jie; Maynes, Daniel; Tolley, H Dennis; Belnap, David M; Woolley, Adam T; Lee, Milton L; Hawkins, Aaron R

    2010-01-21

    Nanofluidic systems offer advantages for chemical analysis, including small sample volumes, size-selective particle trapping, sample concentration and the ability to separate and detect single molecules. Such systems can be fabricated using planar nanochannels, which rely on standard photolithographic techniques. Nanochannel fluid flow can be driven by capillary action, which benefits from simple injection and reasonably high flow rates. We demonstrate an analysis chip fabricated with planar nanochannels that consist of two adjoining segments of different heights. When nano-analytes elute through the channel, they become physically trapped when the channel dimensions shrink below the size of the particles. We demonstrate the capability of these devices to trap and concentrate by using the following: 120-nm polymer beads, 30-nm polymer beads, Herpes simplex virus 1 capsids, and hepatitis B virus capsids. Each species was fluorescently labeled and its resulting fluorescent signal was detected using a cooled CCD camera. We show how the signal-to-noise ratio of trapped analyte intensity varies linearly with analyte concentration. The goal of this work is to eventually perform size-based fractionation of a variety of nanoparticles, including biomolecules such as proteins.

  5. Selective and lithography-independent fabrication of 20 nm nano-gap electrodes and nano-channels for nanoelectrofluidics applications

    International Nuclear Information System (INIS)

    Zhang, J Y; Wang, X F; Wang, X D; Fan, Z C; Li, Y; Ji, An; Yang, F H

    2010-01-01

    A new method has been developed to selectively fabricate nano-gap electrodes and nano-channels by conventional lithography. Based on a sacrificial spacer process, we have successfully obtained sub-100-nm nano-gap electrodes and nano-channels and further reduced the dimensions to 20 nm by shrinking the sacrificial spacer size. Our method shows good selectivity between nano-gap electrodes and nano-channels due to different sacrificial spacer etch conditions. There is no length limit for the nano-gap electrode and the nano-channel. The method reported in this paper also allows for wafer scale fabrication, high throughput, low cost, and good compatibility with modern semiconductor technology.

  6. Is there really natural selection affecting the l frequencies (long hair) in the Brazilian cat populations?

    Science.gov (United States)

    Ruiz-Garcia, M

    2000-01-01

    The scientific literature on cat genetics contains a presumed typical example of natural selection affecting l frequencies (long hair) in 16 Brazilian cat populations. It has been observed that the hotter and more tropical the climate in Brazil, the lower the values of l frequencies in the cat populations. Nevertheless, this study of some new cat populations in Latin America showed that all of them, independent of the climate, had high or very high l frequencies. l postulate that an alternative migrational-historical hypothesis exists that explains the correlation between the l frequencies and climate characteristics (which are correlated with the latitude) without using natural selection explanations concerning the appearance of the l allele in Brazil.

  7. Coded performance of a fast frequency-hopped noncoherent BFSK ratio statistic receiver over a Rician fading channel with partial-band interference

    OpenAIRE

    Betancourt R., Miguel A.

    1992-01-01

    Approved for public release; distribution is unlimited A frequency-hopping binary frequency shift keying (BSFK) ratio-statistic receiver with multihops per data bit is an effective electronic counter-countermeasures (ECCM) system against partial-band jamming interference. Interference is modeled as Gaussian noise. Orthogonal binary signaling and independent fading diversity is considered over frequency-nonselective, slow fading Rayleigh, Rician, and Gaussian channels. A forward error co...

  8. Symbol Error Probability of DF Relay Selection over Arbitrary Nakagami-m Fading Channels

    Directory of Open Access Journals (Sweden)

    George C. Alexandropoulos

    2013-01-01

    Full Text Available We present a new analytical expression for the moment generating function (MGF of the end-to-end signal-to-noise ratio of dual-hop decode-and-forward (DF relaying systems with relay selection when operating over Nakagami-m fading channels. The derived MGF expression, which is valid for arbitrary values of the fading parameters of both hops, is subsequently utilized to evaluate the average symbol error probability (ASEP of M-ary phase shift keying modulation for the considered DF relaying scheme under various asymmetric fading conditions. It is shown that the MGF-based ASEP performance evaluation results are in excellent agreement with equivalent ones obtained by means of computer simulations, thus validating the correctness of the presented MGF expression.

  9. Diphtheria toxin-induced channels in Vero cells selective for monovalent cations

    International Nuclear Information System (INIS)

    Sandvig, K.; Olsnes, S.

    1988-01-01

    Ion fluxes associated with translocation of diphtheria toxin across the surface membrane of Vero cells were studied. When cells with surface-bound toxin were exposed to low pH to induce toxin entry, the cells became permeable to Na+, K+, H+, choline+, and glucosamine+. There was no increased permeability to Cl-, SO4(-2), glucose, or sucrose, whereas the uptake of 45 Ca2+ was slightly increased. The influx of Ca2+, which appears to be different from that of monovalent cations, was reduced by several inhibitors of anion transport and by verapamil, Mn2+, Co2+, and Ca2+, but not by Mg2+. The toxin-induced fluxes of N+, K+, and protons were inhibited by Cd2+. Cd2+ also protected the cells against intoxication by diphtheria toxin, suggesting that the open cation-selective channel is required for toxin translocation. The involvement of the toxin receptor is discussed

  10. Channel Selection and Feature Projection for Cognitive Load Estimation Using Ambulatory EEG

    Directory of Open Access Journals (Sweden)

    Tian Lan

    2007-01-01

    Full Text Available We present an ambulatory cognitive state classification system to assess the subject's mental load based on EEG measurements. The ambulatory cognitive state estimator is utilized in the context of a real-time augmented cognition (AugCog system that aims to enhance the cognitive performance of a human user through computer-mediated assistance based on assessments of cognitive states using physiological signals including, but not limited to, EEG. This paper focuses particularly on the offline channel selection and feature projection phases of the design and aims to present mutual-information-based techniques that use a simple sample estimator for this quantity. Analyses conducted on data collected from 3 subjects performing 2 tasks (n-back/Larson at 2 difficulty levels (low/high demonstrate that the proposed mutual-information-based dimensionality reduction scheme can achieve up to 94% cognitive load estimation accuracy.

  11. Criteria for Selection of Frequency of Electromagnetic Radiation for Underwater proximity Fuzes

    OpenAIRE

    Sanagapallea Koteswara Rao

    1991-01-01

    Electromagnetic proximity fuzes play important role in underwater weapons. The characteristics of the electromagnetic field, i.e., the wavelength, penetration, propagation constant, velocity, etc in sea water are different from those in air. The conducting properties of the medium are strongly dependent on the frequency of the electromagnetic waves. This paper highlights the basis for selection of frequency of electromagnetic propagation for such applications as proximity fuze for unde...

  12. Effect of photonic crystal and frequency selective surface implementation on gain enhancement in the microstrip patch antenna at terahertz frequency

    Science.gov (United States)

    Nejati, Ameneh; Sadeghzadeh, Ramezan Ali; Geran, Fatemeh

    2014-09-01

    In this paper, microstrip patch antenna with frequency selective surface (FSS) and photonic band gap (PBG) structures in the frequency range of 0.5-0.7 THz is presented for wireless communications. Proposed patch antenna is designed on a substrate with uniform and non-uniform PBG structures. Here, the effects of substrate thickness, various radii and arrangement of holes on antenna resonance in both PBG forms are studied. Near zero characteristic on uniform and non-uniform PBG substrate is compared and the results show that along with increase in hole radius, antenna operating frequency and bandwidth are increased. Also, the FSS structure is designed as a perfect absorber. Finally, by using FSS and PBG structures simultaneously, gain enhancement, increase in directivity and pattern shaping are studied at THz field. The antenna gain in final structure is increased by 2 dBi (32%) in comparison to simple form and Half-Power beam width is reduced from 100°×80° in simple form to 72°×48° by using FSS and PBG. All simulations and designs are done by Ansoft HFSS and CST Microwave Studio simulation tools with different full wave methods.

  13. Least-squares reverse time migration of marine data with frequency-selection encoding

    KAUST Repository

    Dai, Wei

    2013-08-20

    The phase-encoding technique can sometimes increase the efficiency of the least-squares reverse time migration (LSRTM) by more than one order of magnitude. However, traditional random encoding functions require all the encoded shots to share the same receiver locations, thus limiting the usage to seismic surveys with a fixed spread geometry. We implement a frequency-selection encoding strategy that accommodates data with a marine streamer geometry. The encoding functions are delta functions in the frequency domain, so that all the en- coded shots have unique non-overlapping frequency content, and the receivers can distinguish the wavefield from each shot with a unique frequency band. Since the encoding functions are orthogonal to each other, there will be no crosstalk between different shots during modeling and migration. With the frequency-selection encoding method, the computational efficiency of LSRTM is increased so that its cost is compara- ble to conventional RTM for both the Marmousi2 model and a marine data set recorded in the Gulf of Mexico. With more iterations, the LSRTM image quality is further improved. We conclude that LSRTM with frequency-selection is an efficient migration method that can sometimes produce more focused images than conventional RTM.

  14. Least-squares reverse time migration of marine data with frequency-selection encoding

    KAUST Repository

    Dai, Wei

    2013-06-24

    The phase-encoding technique can sometimes increase the efficiency of the least-squares reverse time migration (LSRTM) by more than one order of magnitude. However, traditional random encoding functions require all the encoded shots to share the same receiver locations, thus limiting the usage to seismic surveys with a fixed spread geometry. We implement a frequency-selection encoding strategy that accommodates data with a marine streamer geometry. The encoding functions are delta functions in the frequency domain, so that all the encoded shots have unique nonoverlapping frequency content, and the receivers can distinguish the wavefield from each shot with a unique frequency band. Because the encoding functions are orthogonal to each other, there will be no crosstalk between different shots during modeling and migration. With the frequency-selection encoding method, the computational efficiency of LSRTM is increased so that its cost is comparable to conventional RTM for the Marmousi2 model and a marine data set recorded in the Gulf of Mexico. With more iterations, the LSRTM image quality is further improved by suppressing migration artifacts, balancing reflector amplitudes, and enhancing the spatial resolution. We conclude that LSRTM with frequency-selection is an efficient migration method that can sometimes produce more focused images than conventional RTM. © 2013 Society of Exploration Geophysicists.

  15. Selective attention modulates human auditory brainstem responses: relative contributions of frequency and spatial cues.

    Directory of Open Access Journals (Sweden)

    Alexandre Lehmann

    Full Text Available Selective attention is the mechanism that allows focusing one's attention on a particular stimulus while filtering out a range of other stimuli, for instance, on a single conversation in a noisy room. Attending to one sound source rather than another changes activity in the human auditory cortex, but it is unclear whether attention to different acoustic features, such as voice pitch and speaker location, modulates subcortical activity. Studies using a dichotic listening paradigm indicated that auditory brainstem processing may be modulated by the direction of attention. We investigated whether endogenous selective attention to one of two speech signals affects amplitude and phase locking in auditory brainstem responses when the signals were either discriminable by frequency content alone, or by frequency content and spatial location. Frequency-following responses to the speech sounds were significantly modulated in both conditions. The modulation was specific to the task-relevant frequency band. The effect was stronger when both frequency and spatial information were available. Patterns of response were variable between participants, and were correlated with psychophysical discriminability of the stimuli, suggesting that the modulation was biologically relevant. Our results demonstrate that auditory brainstem responses are susceptible to efferent modulation related to behavioral goals. Furthermore they suggest that mechanisms of selective attention actively shape activity at early subcortical processing stages according to task relevance and based on frequency and spatial cues.

  16. Monitoring voltage-dependent charge displacement of Shaker B-IR K+ ion channels using radio frequency interrogation.

    Directory of Open Access Journals (Sweden)

    Sameera Dharia

    2011-02-01

    Full Text Available Here we introduce a new technique that probes voltage-dependent charge displacements of excitable membrane-bound proteins using extracellularly applied radio frequency (RF, 500 kHz electric fields. Xenopus oocytes were used as a model cell for these experiments, and were injected with cRNA encoding Shaker B-IR (ShB-IR K(+ ion channels to express large densities of this protein in the oocyte membranes. Two-electrode voltage clamp (TEVC was applied to command whole-cell membrane potential and to measure channel-dependent membrane currents. Simultaneously, RF electric fields were applied to perturb the membrane potential about the TEVC level and to measure voltage-dependent RF displacement currents. ShB-IR expressing oocytes showed significantly larger changes in RF displacement currents upon membrane depolarization than control oocytes. Voltage-dependent changes in RF displacement currents further increased in ShB-IR expressing oocytes after ∼120 µM Cu(2+ addition to the external bath. Cu(2+ is known to bind to the ShB-IR ion channel and inhibit Shaker K(+ conductance, indicating that changes in the RF displacement current reported here were associated with RF vibration of the Cu(2+-linked mobile domain of the ShB-IR protein. Results demonstrate the use of extracellular RF electrodes to interrogate voltage-dependent movement of charged mobile protein domains--capabilities that might enable detection of small changes in charge distribution associated with integral membrane protein conformation and/or drug-protein interactions.

  17. Monitoring voltage-dependent charge displacement of Shaker B-IR K+ ion channels using radio frequency interrogation.

    Science.gov (United States)

    Dharia, Sameera; Rabbitt, Richard D

    2011-02-28

    Here we introduce a new technique that probes voltage-dependent charge displacements of excitable membrane-bound proteins using extracellularly applied radio frequency (RF, 500 kHz) electric fields. Xenopus oocytes were used as a model cell for these experiments, and were injected with cRNA encoding Shaker B-IR (ShB-IR) K(+) ion channels to express large densities of this protein in the oocyte membranes. Two-electrode voltage clamp (TEVC) was applied to command whole-cell membrane potential and to measure channel-dependent membrane currents. Simultaneously, RF electric fields were applied to perturb the membrane potential about the TEVC level and to measure voltage-dependent RF displacement currents. ShB-IR expressing oocytes showed significantly larger changes in RF displacement currents upon membrane depolarization than control oocytes. Voltage-dependent changes in RF displacement currents further increased in ShB-IR expressing oocytes after ∼120 µM Cu(2+) addition to the external bath. Cu(2+) is known to bind to the ShB-IR ion channel and inhibit Shaker K(+) conductance, indicating that changes in the RF displacement current reported here were associated with RF vibration of the Cu(2+)-linked mobile domain of the ShB-IR protein. Results demonstrate the use of extracellular RF electrodes to interrogate voltage-dependent movement of charged mobile protein domains--capabilities that might enable detection of small changes in charge distribution associated with integral membrane protein conformation and/or drug-protein interactions.

  18. Comparative Analysis of Selected High Frequency Words Found in Commercial Spelling Series and Misspelled in Students' Writing to a Standard Measure of Word Frequency.

    Science.gov (United States)

    Hagerty, Patricia Jo

    A major purpose of this study was to determine whether a selected number of current, commercially prepared spelling series used high frequency words for their word lists. A second purpose was to determine whether students misspelled high frequency words in their writing. Eleven commercially prepared spelling series were selected according to the…

  19. Predicting the impact of selection for scrapie resistance on PRNP genotype frequencies in goats.

    Science.gov (United States)

    Sacchi, Paola; Rasero, Roberto; Ru, Giuseppe; Aiassa, Eleonora; Colussi, Silvia; Ingravalle, Francesco; Peletto, Simone; Perrotta, Maria Gabriella; Sartore, Stefano; Soglia, Dominga; Acutis, Pierluigi

    2018-03-06

    The European Union has implemented breeding programmes to increase scrapie resistance in sheep. A similar approach can be applied also in goats since the K222 allele provides a level of resistance equivalent to that of ARR in sheep. The European Food Safety Authority stated that breeding for resistance could be offered as an option for Member States to control classical scrapie in goats. We assessed the impact of different breeding strategies on PRNP genotype frequencies using a mathematical model that describes in detail the evolution of K222 in two goat breeds, Chamois Coloured and Saanen. Different patterns of age structure and replacement rate were modelled as factors affecting response to selection. Breeding for scrapie resistance can be implemented in goats, even though the initial K222 frequencies in these breeds are not particularly favourable and the rate at which the resistant animals increase, both breeding and slaughtered for meat production, is slow. If the goal is not to achieve the fixation of resistance allele, it is advisable to carry out selection only until a desired frequency of K222-carriers has been attained. Nucleus selection vs. selection on the overall populations is less expensive but takes longer to reach the desired output. The programme performed on the two goat breeds serves as a model of the response the selection could have in other breeds that show different initial frequencies and population structure. In this respect, the model has a general applicability.

  20. Signatures of positive selection: from selective sweeps at individual loci to subtle allele frequency changes in polygenic adaptation.

    Science.gov (United States)

    Stephan, Wolfgang

    2016-01-01

    In the past 15 years, numerous methods have been developed to detect selective sweeps underlying adaptations. These methods are based on relatively simple population genetic models, including one or two loci at which positive directional selection occurs, and one or two marker loci at which the impact of selection on linked neutral variation is quantified. Information about the phenotype under selection is not included in these models (except for fitness). In contrast, in the quantitative genetic models of adaptation, selection acts on one or more phenotypic traits, such that a genotype-phenotype map is required to bridge the gap to population genetics theory. Here I describe the range of population genetic models from selective sweeps in a panmictic population of constant size to evolutionary traffic when simultaneous sweeps at multiple loci interfere, and I also consider the case of polygenic selection characterized by subtle allele frequency shifts at many loci. Furthermore, I present an overview of the statistical tests that have been proposed based on these population genetics models to detect evidence for positive selection in the genome. © 2015 John Wiley & Sons Ltd.

  1. ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters.

    Science.gov (United States)

    Hanukoglu, Israel

    2017-02-01

    The acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) are members of a superfamily of channels that play critical roles in mechanosensation, chemosensation, nociception, and regulation of blood volume and pressure. These channels look and function like a tripartite funnel that directs the flow of Na + ions into the cytoplasm via the channel pore in the membrane. The subunits that form these channels share a common structure with two transmembrane segments (TM1 and TM2) and a large extracellular part. In most vertebrates, there are five paralogous genes that code for ASICs (ASIC1-ASIC5), and four for ENaC subunits alpha, beta, gamma, and delta (α, β, γ, and δ). While ASICs can form functional channels as a homo- or heterotrimer, ENaC functions as an obligate heterotrimer composed of α-β-γ or β-γ-δ subunits. The structure of ASIC has been determined in several conformations, including desensitized and open states. This review presents a comparison of the structures of these states using easy-to-understand molecular models of the full complex, the central tunnel that includes an outer vestibule, the channel pore, and ion selectivity filter. The differences in the secondary, tertiary, and quaternary structures of the states are summarized to pinpoint the conformational changes responsible for channel opening. Results of site-directed mutagenesis studies of ENaC subunits are examined in light of ASIC1 models. Based on these comparisons, a molecular model for the selectivity filter of ENaC is built by in silico mutagenesis of an ASIC1 structure. These models suggest that Na + ions pass through the filter in a hydrated state. © 2016 Federation of European Biochemical Societies.

  2. Performance Analysis of OFDM in Frequency Selective, Slowly Fading Nakagami Channels

    Science.gov (United States)

    2001-12-01

    Digital Subscriber Line ( ADSL ), and the IEEE 802.11a wireless local area networking high speed physical layer standard. In this thesis the IEEE...Asymmetric Digital Subscriber Line ( ADSL ), and IEEE 802.11a high data-rate wireless local area network (WLAN) applications just to name a few. Since the...standard such as DVB or ADSL . In an application perhaps more relevant to the mission of the Department of Defense (DOD), one can explore the

  3. The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1.

    Science.gov (United States)

    Wang, Junjie; Jackson, David George; Dahl, Gerhard

    2013-05-01

    The food dye FD&C Blue No. 1 (Brilliant Blue FCF [BB FCF]) is structurally similar to the purinergic receptor antagonist Brilliant Blue G (BBG), which is a well-known inhibitor of the ionotropic P2X7 receptor (P2X7R). The P2X7R functionally interacts with the membrane channel protein pannexin 1 (Panx1) in inflammasome signaling. Intriguingly, ligands to the P2X7R, regardless of whether they are acting as agonists or antagonists at the receptor, inhibit Panx1 channels. Thus, because both P2X7R and Panx1 are inhibited by BBG, the diagnostic value of the drug is limited. Here, we show that the food dye BB FCF is a selective inhibitor of Panx1 channels, with an IC50 of 0.27 µM. No significant effect was observed with concentrations as high as 100 µM of BB FCF on P2X7R. Differing by just one hydroxyl group from BB FCF, the food dye FD&C Green No. 3 exhibited similar selective inhibition of Panx1 channels. A reverse selectivity was observed for the P2X7R antagonist, oxidized ATP, which in contrast to other P2X7R antagonists had no significant inhibitory effect on Panx1 channels. Based on its selective action, BB FCF can be added to the repertoire of drugs to study the physiology of Panx1 channels. Furthermore, because Panx1 channels appear to be involved directly or indirectly through P2X7Rs in several disorders, BB FCF and derivatives of this "safe" food dye should be given serious consideration for pharmacological intervention of conditions such as acute Crohn's disease, stroke, and injuries to the central nervous system.

  4. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels.

    Science.gov (United States)

    Ase, Ariel R; Honson, Nicolette S; Zaghdane, Helmi; Pfeifer, Tom A; Séguéla, Philippe

    2015-04-01

    P2X4 is an ATP-gated nonselective cation channel highly permeable to calcium. There is increasing evidence that this homomeric purinoceptor, which is expressed in several neuronal and immune cell types, is involved in chronic pain and inflammation. The current paucity of unambiguous pharmacological tools available to interrogate or modulate P2X4 function led us to pursue the search for selective antagonists. In the high-throughput screen of a compound library, we identified the phenylurea BX430 (1-(2,6-dibromo-4-isopropyl-phenyl)-3-(3-pyridyl)urea, molecular weight = 413), with antagonist properties on human P2X4-mediated calcium uptake. Patch-clamp electrophysiology confirmed direct inhibition of P2X4 currents by extracellular BX430, with submicromolar potency (IC50 = 0.54 µM). BX430 is highly selective, having virtually no functional impact on all other P2X subtypes, namely, P2X1-P2X3, P2X5, and P2X7, at 10-100 times its IC50. Unexpected species differences were noticed, as BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs. The concentration-response curve for ATP on human P2X4 in the presence of BX430 shows an insurmountable blockade, indicating a noncompetitive allosteric mechanism of action. Using a fluorescent dye uptake assay, we observed that BX430 also effectively suppresses ATP-evoked and ivermectin-potentiated membrane permeabilization induced by P2X4 pore dilation. Finally, in single-cell calcium imaging, we validated its selective inhibitory effects on native P2X4 channels at the surface of human THP-1 cells that were differentiated into macrophages. In summary, this ligand provides a novel molecular probe to assess the specific role of P2X4 in inflammatory and neuropathic conditions, where ATP signaling has been shown to be dysfunctional. Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics.

  5. Asymptotic Performance Analysis of the k-th Best Link Selection over Wireless Fading Channels: An Extreme Value Theory Approach

    KAUST Repository

    Al-Badarneh, Yazan Hussein

    2018-01-25

    We consider a general selection-diversity (SD) scheme in which the k-th best link is selected from a number of links. We use extreme value theory (EVT) to derive simple closed-form asymptotic expressions for the average throughput, effective throughput and average bit error probability (BEP) for the k-th best link over various channel models that are widely used to characterize fading in wireless communication systems. As an application example, we consider the Weibull fading channel model and verify the accuracy of the derived asymptotic expressions through Monte Carlo simulations.

  6. Agile Blocker and Clock Jitter Tolerant Low-Power Frequency Selective Receiver with Energy Harvesting Capability.

    Science.gov (United States)

    Hasan, Abul; Helaoui, Mohamed; Ghannouchi, Fadhel M

    2017-08-29

    In this article, a novel tunable, blocker and clock jitter tolerant, low power, quadrature phase shift frequency selective (QPS-FS) receiver with energy harvesting capability is proposed. The receiver's design embraces and integrates (i) the baseband to radio frequency (RF) impedance translation concept to improve selectivity over that of conventional homodyne receiver topologies and (ii) broadband quadrature phase shift circuitry in the RF path to remove an active multi-phase clock generation circuit in passive mixer (PM) receivers. The use of a single local oscillator clock signal with a passive clock division network improves the receiver's robustness against clock jitter and reduces the source clock frequency by a factor of N, compared to PM receivers using N switches (N≥4). As a consequence, the frequency coverage of the QPS-FS receiver is improved by a factor of N, given a clock source of maximum frequency; and, the power consumption of the whole receiver system can eventually be reduced. The tunable QPS-FS receiver separates the wanted RF band signal from the unwanted blockers/interferers. The desired RF signal is frequency down-converted to baseband, while the undesired blocker/interferer signals are reflected by the receiver, collected and could be energy recycled using an auxiliary energy harvesting device.

  7. Extracting time-frequency feature of single-channel vastus medialis EMG signals for knee exercise pattern recognition.

    Science.gov (United States)

    Zhang, Yi; Li, Peiyang; Zhu, Xuyang; Su, Steven W; Guo, Qing; Xu, Peng; Yao, Dezhong

    2017-01-01

    The EMG signal indicates the electrophysiological response to daily living of activities, particularly to lower-limb knee exercises. Literature reports have shown numerous benefits of the Wavelet analysis in EMG feature extraction for pattern recognition. However, its application to typical knee exercises when using only a single EMG channel is limited. In this study, three types of knee exercises, i.e., flexion of the leg up (standing), hip extension from a sitting position (sitting) and gait (walking) are investigated from 14 healthy untrained subjects, while EMG signals from the muscle group of vastus medialis and the goniometer on the knee joint of the detected leg are synchronously monitored and recorded. Four types of lower-limb motions including standing, sitting, stance phase of walking, and swing phase of walking, are segmented. The Wavelet Transform (WT) based Singular Value Decomposition (SVD) approach is proposed for the classification of four lower-limb motions using a single-channel EMG signal from the muscle group of vastus medialis. Based on lower-limb motions from all subjects, the combination of five-level wavelet decomposition and SVD is used to comprise the feature vector. The Support Vector Machine (SVM) is then configured to build a multiple-subject classifier for which the subject independent accuracy will be given across all subjects for the classification of four types of lower-limb motions. In order to effectively indicate the classification performance, EMG features from time-domain (e.g., Mean Absolute Value (MAV), Root-Mean-Square (RMS), integrated EMG (iEMG), Zero Crossing (ZC)) and frequency-domain (e.g., Mean Frequency (MNF) and Median Frequency (MDF)) are also used to classify lower-limb motions. The five-fold cross validation is performed and it repeats fifty times in order to acquire the robust subject independent accuracy. Results show that the proposed WT-based SVD approach has the classification accuracy of 91.85%±0.88% which

  8. Extracting time-frequency feature of single-channel vastus medialis EMG signals for knee exercise pattern recognition.

    Directory of Open Access Journals (Sweden)

    Yi Zhang

    Full Text Available The EMG signal indicates the electrophysiological response to daily living of activities, particularly to lower-limb knee exercises. Literature reports have shown numerous benefits of the Wavelet analysis in EMG feature extraction for pattern recognition. However, its application to typical knee exercises when using only a single EMG channel is limited. In this study, three types of knee exercises, i.e., flexion of the leg up (standing, hip extension from a sitting position (sitting and gait (walking are investigated from 14 healthy untrained subjects, while EMG signals from the muscle group of vastus medialis and the goniometer on the knee joint of the detected leg are synchronously monitored and recorded. Four types of lower-limb motions including standing, sitting, stance phase of walking, and swing phase of walking, are segmented. The Wavelet Transform (WT based Singular Value Decomposition (SVD approach is proposed for the classification of four lower-limb motions using a single-channel EMG signal from the muscle group of vastus medialis. Based on lower-limb motions from all subjects, the combination of five-level wavelet decomposition and SVD is used to comprise the feature vector. The Support Vector Machine (SVM is then configured to build a multiple-subject classifier for which the subject independent accuracy will be given across all subjects for the classification of four types of lower-limb motions. In order to effectively indicate the classification performance, EMG features from time-domain (e.g., Mean Absolute Value (MAV, Root-Mean-Square (RMS, integrated EMG (iEMG, Zero Crossing (ZC and frequency-domain (e.g., Mean Frequency (MNF and Median Frequency (MDF are also used to classify lower-limb motions. The five-fold cross validation is performed and it repeats fifty times in order to acquire the robust subject independent accuracy. Results show that the proposed WT-based SVD approach has the classification accuracy of 91.85%±0

  9. Individual Alpha Peak Frequency Predicts 10 Hz Flicker Effects on Selective Attention.

    Science.gov (United States)

    Gulbinaite, Rasa; van Viegen, Tara; Wieling, Martijn; Cohen, Michael X; VanRullen, Rufin

    2017-10-18

    Rhythmic visual stimulation ("flicker") is primarily used to "tag" processing of low-level visual and high-level cognitive phenomena. However, preliminary evidence suggests that flicker may also entrain endogenous brain oscillations, thereby modulating cognitive processes supported by those brain rhythms. Here we tested the interaction between 10 Hz flicker and endogenous alpha-band (∼10 Hz) oscillations during a selective visuospatial attention task. We recorded EEG from human participants (both genders) while they performed a modified Eriksen flanker task in which distractors and targets flickered within (10 Hz) or outside (7.5 or 15 Hz) the alpha band. By using a combination of EEG source separation, time-frequency, and single-trial linear mixed-effects modeling, we demonstrate that 10 Hz flicker interfered with stimulus processing more on incongruent than congruent trials (high vs low selective attention demands). Crucially, the effect of 10 Hz flicker on task performance was predicted by the distance between 10 Hz and individual alpha peak frequency (estimated during the task). Finally, the flicker effect on task performance was more strongly predicted by EEG flicker responses during stimulus processing than during preparation for the upcoming stimulus, suggesting that 10 Hz flicker interfered more with reactive than proactive selective attention. These findings are consistent with our hypothesis that visual flicker entrained endogenous alpha-band networks, which in turn impaired task performance. Our findings also provide novel evidence for frequency-dependent exogenous modulation of cognition that is determined by the correspondence between the exogenous flicker frequency and the endogenous brain rhythms. SIGNIFICANCE STATEMENT Here we provide novel evidence that the interaction between exogenous rhythmic visual stimulation and endogenous brain rhythms can have frequency-specific behavioral effects. We show that alpha-band (10 Hz) flicker impairs stimulus

  10. Detection of optic nerve lesions in optic neuritis using frequency-selective fat-saturation sequences

    International Nuclear Information System (INIS)

    Miller, D.H.; MacManus, D.G.; Bartlett, P.A.; Kapoor, R.; Morrissey, S.P.; Moseley, I.F.

    1993-01-01

    MRI was performed on seven patients with acute optic neuritis, using two sequences which suppress the signal from orbital fat: frequency-selective fat-saturation and inversion recovery with a short inversion time. Lesions were seen on both sequences in all the symptomatic optic nerves studied. (orig.)

  11. TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia.

    Science.gov (United States)

    Ma, Liqun; Zhang, Xuexin; Chen, Haijun

    2011-06-07

    Background potassium (K+) channels, which are normally selectively permeable to K+, maintain the cardiac resting membrane potential at around -80 mV. In subphysiological extracellular K+ concentrations ([K+]o), which occur in pathological hypokalemia, the resting membrane potential of human cardiomyocytes can depolarize to around -50 mV, whereas rat and mouse cardiomyocytes become hyperpolarized, consistent with the Nernst equation for K+. This paradoxical depolarization of cardiomyocytes in subphysiological [K+]o, which may contribute to cardiac arrhythmias, is thought to involve an inward leak sodium (Na+) current. Here, we show that human cardiac TWIK-1 (also known as K2P1) two-pore domain K+ channels change ion selectivity, becoming permeable to external Na+, and conduct inward leak Na+ currents in subphysiological [K+]o. A specific threonine residue (Thr118) within the pore selectivity sequence TxGYG was required for this altered ion selectivity. Mouse cardiomyocyte-derived HL-1 cells exhibited paradoxical depolarization with ectopic expression of TWIK-1 channels, whereas TWIK-1 knockdown in human spherical primary cardiac myocytes eliminated paradoxical depolarization. These findings indicate that ion selectivity of TWIK-1 K+ channels changes during pathological hypokalemia, elucidate a molecular basis for inward leak Na+ currents that could trigger or contribute to cardiac paradoxical depolarization in lowered [K+]o, and identify a mechanism for regulating cardiac excitability.

  12. [Potential-dependent changes in the ionic selectivity of batrachotoxin-modified sodium channels of a frog nerve fiber].

    Science.gov (United States)

    Mozhaeva, G N; Naumov, A P; Khodorov, B I

    1983-01-01

    Currents through batrachotoxin-modified sodium channels in frog myelinated fibres were measured under voltage-clamp conditions. Reversal potential (Erev) of steady-state currents is shown to be about 5 mV less positive than Erev of initial (peak) currents. Control experiments with procaine and tetrodotoxin in external solutions showed that this shift of Erev during depolarizing pulse cannot be accounted for by the presence of unmodified sodium channels, unblocked potassium channels, nonlinearity of the leakage or any changes in transmembrane gradients of current-carrying cations. "Instantaneous" current measurements showed that Erev becomes less positive as amplitude and duration of preliminary depolarization increase. The results obtained are consistent with assumption that sodium-potassium selectivity of the batrachotoxin-modified channels depends on potential.

  13. K⁺-dependent selectivity and external Ca²⁺ block of Shab K⁺ channels.

    Science.gov (United States)

    Carrillo, Elisa; Pacheco, Lucero; Balleza, Daniel; Gomez-Lagunas, Froylan

    2015-01-01

    Potassium channels allow the selective flux of K⁺ excluding the smaller, and more abundant in the extracellular solution, Na⁺ ions. Here we show that Shab is a typical K⁺ channel that excludes Na⁺ under bi-ionic, Na(o)/K(i) or Na(o)/Rb(i), conditions. However, when internal K⁺ is replaced by Cs⁺ (Na(o)/Cs(i)), stable inward Na⁺ and outward Cs⁺ currents are observed. These currents show that Shab selectivity is not accounted for by protein structural elements alone, as implicit in the snug-fit model of selectivity. Additionally, here we report the block of Shab channels by external Ca²⁺ ions, and compare the effect that internal K⁺ replacement exerts on both Ca²⁺ and TEA block. Our observations indicate that Ca²⁺ blocks the channels at a site located near the external TEA binding site, and that this pore region changes conformation under conditions that allow Na⁺ permeation. In contrast, the latter ion conditions do not significantly affect the binding of quinidine to the pore central cavity. Based on our observations and the structural information derived from the NaK bacterial channel, we hypothesize that Ca²⁺ is probably coordinated by main chain carbonyls of the pore's first K⁺-binding site.

  14. Ferrite Film Loaded Frequency Selective Metamaterials for Sub-GHz Applications

    Directory of Open Access Journals (Sweden)

    Bo Gao

    2016-12-01

    Full Text Available Electromagnetic metamaterials are constructed with sub-wavelength structures that exhibit particular electromagnetic properties under a certain frequency range. Because the form-factor of the substructures has to be comparable to the wavelength of the operating frequency, few papers have discussed the metamaterials under GHz frequency. In this paper, we developed an innovative method to reduce the resonant frequency of metamaterals. By integrating the meta-structures with ferrite materials of higher permeability, the cell size of the meta-structure can be scaled down. This paper describes the methodology, design, and development of low-profile GHz ferrite loaded metamaterials. A ferrite film with a permeability of 20 could reduce the resonant frequency of metamaterials by up to 50%. A prototype has been fabricated and the measurement data align well with the simulation results. Because of the lowered operational frequency, the proposed ferrite loaded metamaterials offer more flexibility for various sub-GHz microwave applications, such as cloaks, absorbers, and frequency selective surfaces.

  15. Differential Regulation of Action Potential Shape and Burst-Frequency Firing by BK and Kv2 Channels in Substantia Nigra Dopaminergic Neurons.

    Science.gov (United States)

    Kimm, Tilia; Khaliq, Zayd M; Bean, Bruce P

    2015-12-16

    Little is known about the voltage-dependent potassium currents underlying spike repolarization in midbrain dopaminergic neurons. Studying mouse substantia nigra pars compacta dopaminergic neurons both in brain slice and after acute dissociation, we found that BK calcium-activated potassium channels and Kv2 channels both make major contributions to the depolarization-activated potassium current. Inhibiting Kv2 or BK channels had very different effects on spike shape and evoked firing. Inhibiting Kv2 channels increased spike width and decreased the afterhyperpolarization, as expected for loss of an action potential-activated potassium conductance. BK inhibition also increased spike width but paradoxically increased the afterhyperpolarization. Kv2 channel inhibition steeply increased the slope of the frequency-current (f-I) relationship, whereas BK channel inhibition had little effect on the f-I slope or decreased it, sometimes resulting in slowed firing. Action potential clamp experiments showed that both BK and Kv2 current flow during spike repolarization but with very different kinetics, with Kv2 current activating later and deactivating more slowly. Further experiments revealed that inhibiting either BK or Kv2 alone leads to recruitment of additional current through the other channel type during the action potential as a consequence of changes in spike shape. Enhancement of slowly deactivating Kv2 current can account for the increased afterhyperpolarization produced by BK inhibition and likely underlies the very different effects on the f-I relationship. The cross-regulation of BK and Kv2 activation illustrates that the functional role of a channel cannot be defined in isolation but depends critically on the context of the other conductances in the cell. This work shows that BK calcium-activated potassium channels and Kv2 voltage-activated potassium channels both regulate action potentials in dopamine neurons of the substantia nigra pars compacta. Although both

  16. How does male-male competition generate negative frequency-dependent selection and disruptive selection during speciation?

    Science.gov (United States)

    Dijkstra, Peter D; Border, Shana E

    2018-02-01

    Natural selection has been shown to drive population differentiation and speciation. The role of sexual selection in this process is controversial; however, most of the work has centered on mate choice while the role of male-male competition in speciation is relatively understudied. Here, we outline how male-male competition can be a source of diversifying selection on male competitive phenotypes, and how this can contribute to the evolution of reproductive isolation. We highlight how negative frequency-dependent selection (advantage of rare phenotype arising from stronger male-male competition between similar male phenotypes compared with dissimilar male phenotypes) and disruptive selection (advantage of extreme phenotypes) drives the evolution of diversity in competitive traits such as weapon size, nuptial coloration, or aggressiveness. We underscore that male-male competition interacts with other life-history functions and that variable male competitive phenotypes may represent alternative adaptive options. In addition to competition for mates, aggressive interference competition for ecological resources can exert selection on competitor signals. We call for a better integration of male-male competition with ecological interference competition since both can influence the process of speciation via comparable but distinct mechanisms. Altogether, we present a more comprehensive framework for studying the role of male-male competition in speciation, and emphasize the need for better integration of insights gained from other fields studying the evolutionary, behavioral, and physiological consequences of agonistic interactions.

  17. How does male–male competition generate negative frequency-dependent selection and disruptive selection during speciation?

    Science.gov (United States)

    Border, Shana E

    2018-01-01

    Abstract Natural selection has been shown to drive population differentiation and speciation. The role of sexual selection in this process is controversial; however, most of the work has centered on mate choice while the role of male–male competition in speciation is relatively understudied. Here, we outline how male–male competition can be a source of diversifying selection on male competitive phenotypes, and how this can contribute to the evolution of reproductive isolation. We highlight how negative frequency-dependent selection (advantage of rare phenotype arising from stronger male–male competition between similar male phenotypes compared with dissimilar male phenotypes) and disruptive selection (advantage of extreme phenotypes) drives the evolution of diversity in competitive traits such as weapon size, nuptial coloration, or aggressiveness. We underscore that male–male competition interacts with other life-history functions and that variable male competitive phenotypes may represent alternative adaptive options. In addition to competition for mates, aggressive interference competition for ecological resources can exert selection on competitor signals. We call for a better integration of male–male competition with ecological interference competition since both can influence the process of speciation via comparable but distinct mechanisms. Altogether, we present a more comprehensive framework for studying the role of male–male competition in speciation, and emphasize the need for better integration of insights gained from other fields studying the evolutionary, behavioral, and physiological consequences of agonistic interactions. PMID:29492042

  18. Bias characterization of CrIS radiances at 399 selected channels with respect to NWP model simulations

    Science.gov (United States)

    Li, Xin; Zou, Xiaolei

    2017-11-01

    The Cross-track Infrared Sounder (CrIS) on board the Suomi National Polar-Orbiting Partnership (S-NPP) satellite is a hyperspectral Fourier Transform Spectrometer. In this study, biases of the 399 channels used in numerical weather prediction applications are characterized based on the differences between CrIS observations and model simulations in clear-sky conditions over ocean. The Visible Infrared Imaging Radiometer Suite (VIIRS) cloud mask is used for selecting CrIS clear-sky data. The global mean biases are within ± 1 K for most channels (more than 390). Biases for the channels not affected by trace gases other than water vapor in long-wave infrared (LWIR), middle-wave infrared (MWIR) and short-wave infrared (SWIR) bands vary from about - 0.5 to 0.3 K, - 0.2 to 0.8 K, and - 0.1 to 0.9 K, respectively. The scan-angle variations of biases are less than ± 0.4 K for all channels. The MWIR sounding channels have larger biases in middle and high latitudes than the tropics, which might be associated with latitudinal differences of water vapor variability. The SWIR CO2 channels are affected by nonlocal thermodynamic equilibrium (NLTE) in the upper stratosphere and the window channels could be affected by the sun glint effect, both of which are considered in model simulations. Biases of the NLTE affected channels during daytime are found to be 0.5-1 K higher than nighttime. The SWIR window channels have colder biases at Field of Regards (FORs) 6-15 than the other scan positions due to the sun glint effect.

  19. Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes.

    Science.gov (United States)

    Hancock, Jane M; Weatherall, Kate L; Choisy, Stéphanie C; James, Andrew F; Hancox, Jules C; Marrion, Neil V

    2015-05-01

    Activation of small conductance calcium-activated potassium (SK) channels is proposed to contribute to repolarization of the action potential in atrial myocytes. This role is controversial, as these cardiac SK channels appear to exhibit an uncharacteristic pharmacology. The objectives of this study were to resolve whether activation of SK channels contributes to atrial action potential repolarization and to determine the likely subunit composition of the channel. The effect of 2 SK channel inhibitors was assessed on outward current evoked in voltage clamp and on action potential duration in perforated patch and whole-cell current clamp recording from acutely isolated mouse atrial myocytes. The presence of SK channel subunits was assessed using immunocytochemistry. A significant component of outward current was reduced by the SK channel blockers apamin and UCL1684. Block by apamin displayed a sensitivity indicating that this current was carried by homomeric SK2 channels. Action potential duration was significantly prolonged by UCL1684, but not by apamin. This effect was accompanied by an increase in beat-to-beat variability and action potential triangulation. This pharmacology was matched by that of expressed heteromeric SK2-SK3 channels in HEK293 cells. Immunocytochemistry showed that atrial myocytes express both SK2 and SK3 channels with an overlapping expression pattern. Only proposed heteromeric SK2-SK3 channels are physiologically activated to contribute to action potential repolarization, which is indicated by the difference in pharmacology of evoked outward current and prolongation of atrial action potential duration. The effect of blocking this channel on the action potential suggests that SK channel inhibition during cardiac function has the potential to be proarrhythmic. Copyright © 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  20. Vast Volatility Matrix Estimation using High Frequency Data for Portfolio Selection*

    Science.gov (United States)

    Fan, Jianqing; Li, Yingying; Yu, Ke

    2012-01-01

    Portfolio allocation with gross-exposure constraint is an effective method to increase the efficiency and stability of portfolios selection among a vast pool of assets, as demonstrated in Fan et al. (2011). The required high-dimensional volatility matrix can be estimated by using high frequency financial data. This enables us to better adapt to the local volatilities and local correlations among vast number of assets and to increase significantly the sample size for estimating the volatility matrix. This paper studies the volatility matrix estimation using high-dimensional high-frequency data from the perspective of portfolio selection. Specifically, we propose the use of “pairwise-refresh time” and “all-refresh time” methods based on the concept of “refresh time” proposed by Barndorff-Nielsen et al. (2008) for estimation of vast covariance matrix and compare their merits in the portfolio selection. We establish the concentration inequalities of the estimates, which guarantee desirable properties of the estimated volatility matrix in vast asset allocation with gross exposure constraints. Extensive numerical studies are made via carefully designed simulations. Comparing with the methods based on low frequency daily data, our methods can capture the most recent trend of the time varying volatility and correlation, hence provide more accurate guidance for the portfolio allocation in the next time period. The advantage of using high-frequency data is significant in our simulation and empirical studies, which consist of 50 simulated assets and 30 constituent stocks of Dow Jones Industrial Average index. PMID:23264708

  1. Vast Volatility Matrix Estimation using High Frequency Data for Portfolio Selection.

    Science.gov (United States)

    Fan, Jianqing; Li, Yingying; Yu, Ke

    2012-01-01

    Portfolio allocation with gross-exposure constraint is an effective method to increase the efficiency and stability of portfolios selection among a vast pool of assets, as demonstrated in Fan et al. (2011). The required high-dimensional volatility matrix can be estimated by using high frequency financial data. This enables us to better adapt to the local volatilities and local correlations among vast number of assets and to increase significantly the sample size for estimating the volatility matrix. This paper studies the volatility matrix estimation using high-dimensional high-frequency data from the perspective of portfolio selection. Specifically, we propose the use of "pairwise-refresh time" and "all-refresh time" methods based on the concept of "refresh time" proposed by Barndorff-Nielsen et al. (2008) for estimation of vast covariance matrix and compare their merits in the portfolio selection. We establish the concentration inequalities of the estimates, which guarantee desirable properties of the estimated volatility matrix in vast asset allocation with gross exposure constraints. Extensive numerical studies are made via carefully designed simulations. Comparing with the methods based on low frequency daily data, our methods can capture the most recent trend of the time varying volatility and correlation, hence provide more accurate guidance for the portfolio allocation in the next time period. The advantage of using high-frequency data is significant in our simulation and empirical studies, which consist of 50 simulated assets and 30 constituent stocks of Dow Jones Industrial Average index.

  2. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.

    Science.gov (United States)

    Chen, Jun; Joshi, Shailen K; DiDomenico, Stanley; Perner, Richard J; Mikusa, Joe P; Gauvin, Donna M; Segreti, Jason A; Han, Ping; Zhang, Xu-Feng; Niforatos, Wende; Bianchi, Bruce R; Baker, Scott J; Zhong, Chengmin; Simler, Gricelda H; McDonald, Heath A; Schmidt, Robert G; McGaraughty, Steve P; Chu, Katharine L; Faltynek, Connie R; Kort, Michael E; Reilly, Regina M; Kym, Philip R

    2011-05-01

    Despite the increasing interest in TRPA1 channel as a pain target, its role in cold sensation and body temperature regulation is not clear; the efficacy and particularly side effects resulting from channel blockade remain poorly understood. Here we use a potent, selective, and bioavailable antagonist to address these issues. A-967079 potently blocks human (IC(50): 51 nmol/L, electrophysiology, 67 nmol/L, Ca(2+) assay) and rat TRPA1 (IC(50): 101 nmol/L, electrophysiology, 289 nmol/L, Ca(2+) assay). It is >1000-fold selective over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes, and G-protein-coupled receptors. Oral dosing of A-967079 produces robust drug exposure in rodents, and exhibits analgesic efficacy in allyl isothiocyanate-induced nocifensive response and osteoarthritic pain in rats (ED(50): 23.2 mg/kg, p.o.). A-967079 attenuates cold allodynia produced by nerve injury but does not alter noxious cold sensation in naive animals, suggesting distinct roles of TRPA1 in physiological and pathological states. Unlike TRPV1 antagonists, A-967079 does not alter body temperature. It also does not produce locomotor or cardiovascular side effects. Collectively, these data provide novel insights into TRPA1 function and suggest that the selective TRPA1 blockade may present a viable strategy for alleviating pain without untoward side effects. Copyright © 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  3. Cation gating and selectivity in a purified, reconstituted, voltage-dependent sodium channel

    International Nuclear Information System (INIS)

    Barchi, R.L.; Tanaka, J.C.

    1984-01-01

    In excitable membranes, the voltage-dependent sodium channel controls the primary membrane conductance change necessary for the generation of an action potential. Over the past four decades, the time- and voltage-dependent sodium currents gated by this channel have been thoroughly documented with increasingly sophisticated voltage-clamp techniques. Recent advances in the biochemistry of membrane proteins have led to the solubilization and purification of this channel protein from nerve (6) and from muscle (4) or muscle-derived (1) membranes, and have provided an approach to the correlation of the channel's molecular structure with its functional properties. Each of these sodium channel preparations appears to contain a large glycoprotein either as its sole component (2) or in association with several small subunits (6, 3). Evidence that these purified proteins represent the excitable membrane sodium channel is presented. 8 refs., 1 fig., 1 tab

  4. Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Whitehead, Lewis; Dobler, Markus R.; Radetich, Branko; Zhu, Yanyi; Atadja, Peter W.; Claiborne, Tavina; Grob, Jonathan E.; McRiner, Andrew; Pancost, Margaret R.; Patnaik, Anup; Shao, Wenlin; Shultz, Michael; Tichkule, Ritesh; Tommasi, Ruben A.; Vash, Brian; Wang, Ping; Stams, Travis (Novartis)

    2013-11-20

    Herein we report the discovery of a family of novel yet simple, amino-acid derived class I HDAC inhibitors that demonstrate isoform selectivity via access to the internal acetate release channel. Isoform selectivity criteria is discussed on the basis of X-ray crystallography and molecular modeling of these novel inhibitors bound to HDAC8, potentially revealing insights into the mechanism of enzymatic function through novel structural features revealed at the atomic level.

  5. Dynamic frequency feature selection based approach for classification of motor imageries.

    Science.gov (United States)

    Luo, Jing; Feng, Zuren; Zhang, Jun; Lu, Na

    2016-08-01

    Electroencephalography (EEG) is one of the most popular techniques to record the brain activities such as motor imagery, which is of low signal-to-noise ratio and could lead to high classification error. Therefore, selection of the most discriminative features could be crucial to improve the classification performance. However, the traditional feature selection methods employed in brain-computer interface (BCI) field (e.g. Mutual Information-based Best Individual Feature (MIBIF), Mutual Information-based Rough Set Reduction (MIRSR) and cross-validation) mainly focus on the overall performance on all the trials in the training set, and thus may have very poor performance on some specific samples, which is not acceptable. To address this problem, a novel sequential forward feature selection approach called Dynamic Frequency Feature Selection (DFFS) is proposed in this paper. The DFFS method emphasized the importance of the samples that got misclassified while only pursuing high overall classification performance. In the DFFS based classification scheme, the EEG data was first transformed to frequency domain using Wavelet Packet Decomposition (WPD), which is then employed as the candidate set for further discriminatory feature selection. The features are selected one by one in a boosting manner. After one feature being selected, the importance of the correctly classified samples based on the feature will be decreased, which is equivalent to increasing the importance of the misclassified samples. Therefore, a complement feature to the current features could be selected in the next run. The selected features are then fed to a classifier trained by random forest algorithm. Finally, a time series voting-based method is utilized to improve the classification performance. Comparisons between the DFFS-based approach and state-of-art methods on BCI competition IV data set 2b have been conducted, which have shown the superiority of the proposed algorithm. Copyright © 2016

  6. Channel Estimation in DCT-Based OFDM

    Science.gov (United States)

    Wang, Yulin; Zhang, Gengxin; Xie, Zhidong; Hu, Jing

    2014-01-01

    This paper derives the channel estimation of a discrete cosine transform- (DCT-) based orthogonal frequency-division multiplexing (OFDM) system over a frequency-selective multipath fading channel. Channel estimation has been proved to improve system throughput and performance by allowing for coherent demodulation. Pilot-aided methods are traditionally used to learn the channel response. Least square (LS) and mean square error estimators (MMSE) are investigated. We also study a compressed sensing (CS) based channel estimation, which takes the sparse property of wireless channel into account. Simulation results have shown that the CS based channel estimation is expected to have better performance than LS. However MMSE can achieve optimal performance because of prior knowledge of the channel statistic. PMID:24757439

  7. From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group.

    Directory of Open Access Journals (Sweden)

    Sigrid Marie Blom

    Full Text Available The voltage-gated potassium channels of the KV7 family (KV7.1-5 play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability. One of the main challenges in developing KV7 channel active drugs has been to identify compounds capable of discriminating between the neuronally expressed subtypes (KV7.2-5, aiding the identification of the subunit composition of KV7 currents in various tissues, and possessing better therapeutic potential for particular indications. By taking advantage of the structure-activity relationship of acrylamide KV7 channel openers and the effects of these compounds on mutant KV7 channels, we have designed and synthesized a novel KV7 channel modulator with a unique profile. The compound, named SMB-1, is an inhibitor of KV7.2 and an activator of KV7.4. SMB-1 inhibits KV7.2 by reducing the current amplitude and increasing the time constant for the slow component of the activation kinetics. The activation of KV7.4 is seen as an increase in the current amplitude and a slowing of the deactivation kinetics. Experiments studying mutant channels with a compromised binding site for the KV7.2-5 opener retigabine indicate that SMB-1 binds within the same pocket as retigabine for both inhibition of KV7.2 and activation of KV7.4. SMB-1 may serve as a valuable tool for KV7 channel research and may be used as a template for further design of better subtype selective KV7 channel modulators. A compound with this profile could hold novel therapeutic potential such as the treatment of both positive and cognitive symptoms in schizophrenia.

  8. Identification and analysis of genome-wide SNPs provide insight into signatures of selection and domestication in channel catfish (Ictalurus punctatus.

    Directory of Open Access Journals (Sweden)

    Luyang Sun

    Full Text Available Domestication and selection for important performance traits can impact the genome, which is most often reflected by reduced heterozygosity in and surrounding genes related to traits affected by selection. In this study, analysis of the genomic impact caused by domestication and artificial selection was conducted by investigating the signatures of selection using single nucleotide polymorphisms (SNPs in channel catfish (Ictalurus punctatus. A total of 8.4 million candidate SNPs were identified by using next generation sequencing. On average, the channel catfish genome harbors one SNP per 116 bp. Approximately 6.6 million, 5.3 million, 4.9 million, 7.1 million and 6.7 million SNPs were detected in the Marion, Thompson, USDA103, Hatchery strain, and wild population, respectively. The allele frequencies of 407,861 SNPs differed significantly between the domestic and wild populations. With these SNPs, 23 genomic regions with putative selective sweeps were identified that included 11 genes. Although the function for the majority of the genes remain unknown in catfish, several genes with known function related to aquaculture performance traits were included in the regions with selective sweeps. These included hypoxia-inducible factor 1β. HIFιβ.. and the transporter gene ATP-binding cassette sub-family B member 5 (ABCB5. HIF1β. is important for response to hypoxia and tolerance to low oxygen levels is a critical aquaculture trait. The large numbers of SNPs identified from this study are valuable for the development of high-density SNP arrays for genetic and genomic studies of performance traits in catfish.

  9. Allele frequency changes due to hitch-hiking in genomic selection programs

    DEFF Research Database (Denmark)

    Liu, Huiming; Sørensen, Anders Christian; Meuwissen, Theo H E

    2014-01-01

    animals for 25 consecutive generations. Six genetic models were considered with different heritabilities and numbers of QTL (quantitative trait loci) affecting the trait. Four selection criteria were used, including selection on own phenotype and on estimated breeding values (EBV) derived using phenotype......-BLUP, Genomic BLUP and Bayesian Lasso. Changes in allele frequencies at QTL, markers and linked neutral loci were investigated for the different selection criteria and different scenarios, along with the loss of favourable alleles and the rate of inbreeding measured by pedigree and runs of homozygosity. Results......Background Genomic selection makes it possible to reduce pedigree-based inbreeding over best linear unbiased prediction (BLUP) by increasing emphasis on own rather than family information. However, pedigree inbreeding might not accurately reflect the loss of genetic variation and the true level...

  10. Tackling the Combined Effects of Reverberation and Masking Noise Using Ideal Channel Selection

    Science.gov (United States)

    Hazrati, Oldooz; Loizou, Philipos C.

    2012-01-01

    Purpose: In this article, a new signal-processing algorithm is proposed and evaluated for the suppression of the combined effects of reverberation and noise. Method: The proposed algorithm decomposes, on a short-term basis (every 20 ms), the reverberant stimuli into a number of channels and retains only a subset of the channels satisfying a…

  11. Compressive sensing-based channel bandwidth improvement in optical wireless orthogonal frequency division multiplexing link using visible light emitting diode.

    Science.gov (United States)

    Won, Yong-Yuk; Yoon, Sang Min

    2014-08-25

    A new technique, which can compensate for the lack of channel bandwidth in an optical wireless orthogonal frequency division multiplexing (OFDM) link based on a light emitting diode (LED), is proposed. It uses an adaptive sampling and an inverse discrete cosine transform in order to convert an OFDM signal into a sparse waveform so that not only is the important data obtained efficiently but the redundancy one is removed. In compressive sensing (CS), a sparse signal that is sampled below the Nyquist/Shannon limit can be reconstructed successively with enough measurement. This means that the CS technique can increase the data rate of visible light communication (VLC) systems based on LEDs. It is observed that the data rate of the proposed CS-based VLC-OFDM link can be made 1.7 times greater than a conventional VLC-OFDM link (from 30.72 Mb/s to 51.2 Mb/s). We see that the error vector magnitude (EVM) of the quadrature phase shift keying (QPSK) symbol is 31% (FEC limit: EVM of 32%) at a compression ratio of 40%.

  12. A novel metamaterial filter with stable passband performance based on frequency selective surface

    Directory of Open Access Journals (Sweden)

    C. Y. Fang

    2014-07-01

    Full Text Available In this paper, a novel metamaterial filter based on frequency selective surface (FSS is proposed. Using the mode matching method, we theoretically studied the transmission performance of the structure. Results show that, by rotating its neighboring elements 90 degree, the novel filter has a better stability to angle of incidence than traditional structures for TE and TM polarization. As the incident angles vary from 0 to 50 degrees, the metamaterial filter exhibits a transmittance higher than 0.98 and the center frequency slightly shifts downward (from 10 GHz to 0.96 GHz for TE polarization. For TM polarization, a transmittance of 0.98 is achieved and the center frequency retains 0.96 GHz with the varying of the incident angles. Furthermore, an experimental prototype fabricated was tested in a microwave chamber, and the measured results show good agreement with the simulated ones.

  13. A Polarization-Dependent Frequency-Selective Metamaterial Absorber with Multiple Absorption Peaks

    Directory of Open Access Journals (Sweden)

    Guangsheng Deng

    2017-06-01

    Full Text Available A polarization-dependent, frequency-selective metamaterial (MM absorber based on a single-layer patterned resonant structure intended for F frequency band is proposed. The design, fabrication, and measurement for the proposed absorber are presented. The absorber’s absorption properties at resonant frequencies have unique characteristics of a single-band, dual-band, or triple-band absorption for different polarization of the incident wave. The calculated surface current distributions and power loss distribution provide further understanding of physical mechanism of resonance absorption. Moreover, a high absorption for a wide range of TE-polarized oblique incidence was achieved. Hence, the MM structure realized on a highly flexible polyimide film, makingthe absorber suitable for conformal geometry applications. The proposed absorber has great potential in the development of polarization detectors and polarizers.

  14. Program scheme using common source lines in channel stacked NAND flash memory with layer selection by multilevel operation

    Science.gov (United States)

    Kim, Do-Bin; Kwon, Dae Woong; Kim, Seunghyun; Lee, Sang-Ho; Park, Byung-Gook

    2018-02-01

    To obtain high channel boosting potential and reduce a program disturbance in channel stacked NAND flash memory with layer selection by multilevel (LSM) operation, a new program scheme using boosted common source line (CSL) is proposed. The proposed scheme can be achieved by applying proper bias to each layer through its own CSL. Technology computer-aided design (TCAD) simulations are performed to verify the validity of the new method in LSM. Through TCAD simulation, it is revealed that the program disturbance characteristics is effectively improved by the proposed scheme.

  15. Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia

    DEFF Research Database (Denmark)

    Zakrzewska, Joanna M; Palmer, Joanne; Morisset, Valerie

    2017-01-01

    , can be administered at therapeutic doses without titration, and has shown good tolerability in healthy individuals in phase 1 studies. We therefore assessed the safety and efficacy of BIIB074 in patients with trigeminal neuralgia in a phase 2a study. METHODS: We did a double-blind, multicentre......BACKGROUND: Current standard of care for trigeminal neuralgia is treatment with the sodium channel blockers carbamazepine and oxcarbazepine, which although effective are associated with poor tolerability and the need for titration. BIIB074, a Nav1.7-selective, state-dependent sodium-channel blocker...

  16. Performance analysis of best relay selection scheme for amplify-and-forward cooperative networks in identical Nakagami-m channels

    KAUST Repository

    Hussain, Syed Imtiaz

    2010-06-01

    In cooperative communication networks, the use of multiple relays between the source and the destination was proposed to increase the diversity gain. Since the source and all the relays must transmit on orthogonal channels, multiple relay cooperation is considered inefficient in terms of channel resources and bandwidth utilization. To overcome this problem, the concept of best relay selection was recently proposed. In this paper, we analyze the performance of the best relay selection scheme for a cooperative network with multiple relays operating in amplify-and-forward (AF) mode over identical Nakagami-m channels using exact source-relay-destination signal to noise ratio (SNR) expression. We derive accurate closed form expressions for various system parameters including probability density function (pdf) of end-to-end SNR, average output SNR, average probability of bit error and average channel capacity. T he analytical results are verified through extensive simulations. It is shown that the best relay selection scheme performs better than the regular all relay cooperation.

  17. Selecting frequency feature for license plate detection based on AdaBoost

    Science.gov (United States)

    Tan, Huachun; Chen, Hao; Deng, Yafeng; Liu, Junhui

    2009-01-01

    In this paper, a new method for license plate detection based on AdaBoost is proposed. In the new method, character frequency feature, which is powerful feature for detecting license plate character, are introduced to feature pool. The frequency features obtained from the FFT of horizontal projection of binary image are selected by AdaBoost. Then, Haar-like features selected by AdaBoost are used to capture subtle structure of license plate. Furthermore, considering the characteristic of Chinese license plate that there are two types of license plate: deeper background-lighter character and lighter background-deeper character license plates, two detectors are designed to extract different license plates respectively. Experimental results show the efficiency of the proposed method.

  18. A Smartphone Application for Customized Frequency Table Selection in Cochlear Implants.

    Science.gov (United States)

    Jethanamest, Daniel; Azadpour, Mahan; Zeman, Annette M; Sagi, Elad; Svirsky, Mario A

    2017-09-01

    A novel smartphone-based software application can facilitate self-selection of frequency allocation tables (FAT) in postlingually deaf cochlear implant (CI) users. CIs use FATs to represent the tonotopic organization of a normal cochlea. Current CI fitting methods typically use a standard FAT for all patients regardless of individual differences in cochlear size and electrode location. In postlingually deaf patients, different amounts of mismatch can result between the frequency-place function they experienced when they had normal hearing and the frequency-place function that results from the standard FAT. For some CI users, an alternative FAT may enhance sound quality or speech perception. Currently, no widely available tools exist to aid real-time selection of different FATs. This study aims to develop a new smartphone tool for this purpose and to evaluate speech perception and sound quality measures in a pilot study of CI subjects using this application. A smartphone application for a widely available mobile platform (iOS) was developed to serve as a preprocessor of auditory input to a clinical CI speech processor and enable interactive real-time selection of FATs. The application's output was validated by measuring electrodograms for various inputs. A pilot study was conducted in six CI subjects. Speech perception was evaluated using word recognition tests. All subjects successfully used the portable application with their clinical speech processors to experience different FATs while listening to running speech. The users were all able to select one table that they judged provided the best sound quality. All subjects chose a FAT different from the standard FAT in their everyday clinical processor. Using the smartphone application, the mean consonant-nucleus-consonant score with the default FAT selection was 28.5% (SD 16.8) and 29.5% (SD 16.4) when using a self-selected FAT. A portable smartphone application enables CI users to self-select frequency allocation

  19. T-type channels become highly permeable to sodium ions using an alternative extracellular turret region (S5-P) outside the selectivity filter.

    Science.gov (United States)

    Senatore, Adriano; Guan, Wendy; Boone, Adrienne N; Spafford, J David

    2014-04-25

    T-type (Cav3) channels are categorized as calcium channels, but invertebrate ones can be highly sodium-selective channels. We illustrate that the snail LCav3 T-type channel becomes highly sodium-permeable through exon splicing of an extracellular turret and descending helix in domain II of the four-domain Cav3 channel. Highly sodium-permeable T-type channels are generated without altering the invariant ring of charged residues in the selectivity filter that governs calcium selectivity in calcium channels. The highly sodium-permeant T-type channel expresses in the brain and is the only splice isoform expressed in the snail heart. This unique splicing of turret residues offers T-type channels a capacity to serve as a pacemaking sodium current in the primitive heart and brain in lieu of Nav1-type sodium channels and to substitute for voltage-gated sodium channels lacking in many invertebrates. T-type channels would also contribute substantially to sodium leak conductances at rest in invertebrates because of their large window currents.

  20. Radio frequency selective addressing of localized atoms in a periodic potential

    International Nuclear Information System (INIS)

    Ott, H.; De Mirandes, E.; Ferlaino, F.; Roati, G.; Tuerck, V.; Modugno, G.; Inguscio, M.

    2004-01-01

    We study the localization and addressability of ultracold atoms in a combined parabolic and periodic potential. Such a potential supports the existence of localized stationary states and we show that applying a radio frequency field allows us to selectively address atoms in these states. This method is used to measure the energy and momentum distribution of the atoms in the localized states. We also discuss possible extensions of this scheme to address and manipulate atoms in single lattice sites

  1. Activity of the anticonvulsant lacosamide in experimental and human epilepsy via selective effects on slow Na+channel inactivation.

    Science.gov (United States)

    Holtkamp, Dominik; Opitz, Thoralf; Niespodziany, Isabelle; Wolff, Christian; Beck, Heinz

    2017-01-01

    In human epilepsy, pharmacoresistance to antiepileptic drug therapy is a major problem affecting ~30% of patients with epilepsy. Many classical antiepileptic drugs target voltage-gated sodium channels, and their potent activity in inhibiting high-frequency firing has been attributed to their strong use-dependent blocking action. In chronic epilepsy, a loss of use-dependent block has emerged as a potential cellular mechanism of pharmacoresistance for anticonvulsants acting on voltage-gated sodium channels. The anticonvulsant drug lacosamide (LCM) also targets sodium channels, but has been shown to preferentially affect sodium channel slow inactivation processes, in contrast to most other anticonvulsants. We used whole-cell voltage clamp recordings in acutely isolated cells to investigate the effects of LCM on transient Na + currents. Furthermore, we used whole-cell current clamp recordings to assess effects on repetitive action potential firing in hippocampal slices. We show here that LCM exerts its effects primarily via shifting the slow inactivation voltage dependence to more hyperpolarized potentials in hippocampal dentate granule cells from control and epileptic rats, and from patients with epilepsy. It is important to note that this activity of LCM was maintained in chronic experimental and human epilepsy. Furthermore, we demonstrate that the efficacy of LCM in inhibiting high-frequency firing is undiminished in chronic experimental and human epilepsy. Taken together, these results show that LCM exhibits maintained efficacy in chronic epilepsy, in contrast to conventional use-dependent sodium channel blockers such as carbamazepine. They also establish that targeting slow inactivation may be a promising strategy for overcoming target mechanisms of pharmacoresistance. Wiley Periodicals, Inc. © 2016 International League Against Epilepsy.

  2. Data Refinement and Channel Selection for a Portable E-Nose System by the Use of Feature Feedback

    Directory of Open Access Journals (Sweden)

    Yoonseok Yang

    2010-11-01

    Full Text Available We propose a data refinement and channel selection method for vapor classification in a portable e-nose system. For the robust e-nose system in a real environment, we propose to reduce the noise in the data measured by sensor arrays and distinguish the important part in the data by the use of feature feedback. Experimental results on different volatile organic compounds data show that the proposed data refinement method gives good clustering for different classes and improves the classification performance. Also, we design a new sensor array that consists only of the useful channels. For this purpose, each channel is evaluated by measuring its discriminative power based on the feature mask used in the data refinement. Through the experimental results, we show that the new sensor array improves both the classification rates and the efficiency in computation and data storage.

  3. Performance analysis of selective cooperation in amplify-and-forward relay networks over identical Nakagami-m channels

    KAUST Repository

    Hussain, Syed Imtiaz

    2011-05-02

    In cooperative communications, multiple relays between a source and a destination can increase the diversity gain. Because all the nodes must use orthogonal channels, multiple-relay cooperation becomes spectrally inefficient. Therefore, a bestrelay selection scheme was recently proposed. In this paper, we analyzed the performance of this scheme for a system with the relays operating in amplify-and-forward mode over identical Nakagami-m channels using an exact source-relay-destination signal-to-noise ratio (SNR).We derived accurate closed-form expressions for various system parameters including the probability density function of end-to-end SNR, the average output SNR, the bit error probability, and the channel capacity. The analytical results were verified through Monte Carlo simulations. Copyright © 2011 John Wiley & Sons, Ltd.

  4. All-optical UWB generation and modulation using SOA-XPM effect and DWDM-based multi-channel frequency discrimination.

    Science.gov (United States)

    Wang, Fei; Dong, Jianji; Xu, Enming; Zhang, Xinliang

    2010-11-22

    An all-optical UWB pulses generation and modulation scheme using cross phase modulation (XPM) effect of semiconductor optical amplifier (SOA) and DWDM-based multi-channel frequency discrimination is proposed and demonstrated, which has potential application in multiuser UWB-Over-Fiber communication systems. When a Gaussian pulse light and a wavelength-tunable CW probe light are together injected into the SOA, the probe light out from the SOA will have a temporal chirp due to SOA-XPM effect. When the chirped probe light is tuned to the slopes of single DWDM channel transmittance curve, the optical phase modulation to intensity modulation conversion is achieved at DWDM that serves as a multi-channel frequency discriminator, the inverted polarity Gaussian monocycle and doublet pulse is detected by a photodetector, respectively. If the probe lights are simultaneously aimed to different slopes of several DWDM channels, multi-channel or binary-phase-coded UWB signal generation can be acquired. Using proposed scheme, pulse amplitude modulation (PAM), pulse polarity modulation (PPM) and pulse shape modulation (PSM) to UWB pulses also can be conveniently realized.

  5. Bathymetric survey of the Cayuga Inlet flood-control channel and selected tributaries in Ithaca, New York, 2016

    Science.gov (United States)

    Wernly, John F.; Nystrom, Elizabeth A.; Coon, William F.

    2017-09-08

    From July 14 to July 20, 2016, the U.S. Geological Survey, in cooperation with the City of Ithaca, New York, and the New York State Department of State, surveyed the bathymetry of the Cayuga Inlet flood-control channel and the mouths of selected tributaries to Cayuga Inlet and Cayuga Lake in Ithaca, N.Y. The flood-control channel, built by the U.S. Army Corps of Engineers between 1965 and 1970, was designed to convey flood flows from the Cayuga Inlet watershed through the City of Ithaca and minimize possible flood damages. Since that time, the channel has infrequently been maintained by dredging, and sediment accumulation and resultant shoaling have greatly decreased the conveyance of the channel and its navigational capability.U.S. Geological Survey personnel collected bathymetric data by using an acoustic Doppler current profiler. The survey produced a dense dataset of water depths that were converted to bottom elevations. These elevations were then used to generate a geographic information system bathymetric surface. The bathymetric data and resultant bathymetric surface show the current condition of the channel and provide the information that governmental agencies charged with maintaining the Cayuga Inlet for flood-control and navigational purposes need to make informed decisions regarding future maintenance measures.

  6. 12.5 Gb/s multi-channel broadcasting transmission for free-space optical communication based on the optical frequency comb module.

    Science.gov (United States)

    Tan, Jun; Zhao, Zeping; Wang, Yuehui; Zhang, Zhike; Liu, Jianguo; Zhu, Ninghua

    2018-01-22

    A wide-spectrum, ultra-stable optical frequency comb (OFC) module with 100 GHz frequency intervals based on a quantum dot mode locked (QDML) laser is fabricated by our lab, and a scheme with 12.5 Gb/s multi-channel broadcasting transmission for free-space optical (FSO) communication is proposed based on the OFC module. The output power of the OFC is very stable, with the specially designed circuit and the flatness of the frequency comb over the span of 6 nm, which can be limited to 1.5 dB. Four channel wavelengths are chosen to demonstrate one-to-many channels for FSO communication, like optical wireless broadcast. The outdoor experiment is established to test the bit error rate (BER) and eye diagrams with 12.5 Gb/s on-off keying (OOK). The indoor experiment is used to test the highest traffic rate, which is up to 21 Gb/s for one-hop FSO communication. To the best of our knowledge, this scheme is the first to propose the realization of one-to-many broadcasting transmission for FSO communication based on the OFC module. The advantages of integration, miniaturization, channelization, low power consumption, and unlimited bandwidth of one-to-many broadcasting communication scheme, shows promising results on constructing the future space-air-ground-ocean (SAGO) FSO communication networks.

  7. Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3.

    Science.gov (United States)

    Wright, Paul D; Veale, Emma L; McCoull, David; Tickle, David C; Large, Jonathan M; Ococks, Emma; Gothard, Gemma; Kettleborough, Catherine; Mathie, Alistair; Jerman, Jeffrey

    2017-11-04

    Two-pore domain potassium channels (K2Ps) are characterized by their four transmembrane domain and two-pore topology. They carry background (or leak) potassium current in a variety of cell types. Despite a number of important roles there is currently a lack of pharmacological tools with which to further probe K2P function. We have developed a cell-based thallium flux assay, using baculovirus delivered TASK3 (TWIK-related acid-sensitive K + channel 3, KCNK9, K2P9.1) with the aim of identifying novel, selective TASK3 activators. After screening a library of 1000 compounds, including drug-like and FDA approved molecules, we identified Terbinafine as an activator of TASK3. In a thallium flux assay a pEC50 of 6.2 ( ±0.12) was observed. When Terbinafine was screened against TASK2, TREK2, THIK1, TWIK1 and TRESK no activation was observed in thallium flux assays. Several analogues of Terbinafine were also purchased and structure activity relationships examined. To confirm Terbinafine's activation of TASK3 whole cell patch clamp electrophysiology was carried out and clear potentiation observed in both the wild type channel and the pathophysiological, Birk-Barel syndrome associated, G236R TASK3 mutant. No activity at TASK1 was observed in electrophysiology studies. In conclusion, we have identified the first selective activator of the two-pore domain potassium channel TASK3. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Selection an Optimal Control Channel for STATCOM-Based Stabilizers to Damp Inter-Area Oscillation

    OpenAIRE

    A. Samanfar; M. R. Shakarami; R. Sedaghati

    2014-01-01

    In static synchronous compensator (STATCOM) a controllable AC voltage is generated by a voltage-source converter. There are two control channels for controlling of magnitude and phase of the voltage. When these devices are used for damping inter-are oscillations in multi-machine power systems, a damping stabilizer can be applied for both channels. In this paper, a method by quadratic mathematical programming has been presented to design of the damping stabilizer. By this method, the effect of...

  9. A General Model of Negative Frequency Dependent Selection Explains Global Patterns of Human ABO Polymorphism

    Science.gov (United States)

    Villanea, Fernando A.; Safi, Kristin N.; Busch, Jeremiah W.

    2015-01-01

    The ABO locus in humans is characterized by elevated heterozygosity and very similar allele frequencies among populations scattered across the globe. Using knowledge of ABO protein function, we generated a simple model of asymmetric negative frequency dependent selection and genetic drift to explain the maintenance of ABO polymorphism and its loss in human populations. In our models, regardless of the strength of selection, models with large effective population sizes result in ABO allele frequencies that closely match those observed in most continental populations. Populations must be moderately small to fall out of equilibrium and lose either the A or B allele (Ne ≤ 50) and much smaller (Ne ≤ 25) for the complete loss of diversity, which nearly always involved the fixation of the O allele. A pattern of low heterozygosity at the ABO locus where loss of polymorphism occurs in our model is consistent with small populations, such as Native American populations. This study provides a general evolutionary model to explain the observed global patterns of polymorphism at the ABO locus and the pattern of allele loss in small populations. Moreover, these results inform the range of population sizes associated with the recent human colonization of the Americas. PMID:25946124

  10. A General Model of Negative Frequency Dependent Selection Explains Global Patterns of Human ABO Polymorphism.

    Directory of Open Access Journals (Sweden)

    Fernando A Villanea

    Full Text Available The ABO locus in humans is characterized by elevated heterozygosity and very similar allele frequencies among populations scattered across the globe. Using knowledge of ABO protein function, we generated a simple model of asymmetric negative frequency dependent selection and genetic drift to explain the maintenance of ABO polymorphism and its loss in human populations. In our models, regardless of the strength of selection, models with large effective population sizes result in ABO allele frequencies that closely match those observed in most continental populations. Populations must be moderately small to fall out of equilibrium and lose either the A or B allele (N(e ≤ 50 and much smaller (N(e ≤ 25 for the complete loss of diversity, which nearly always involved the fixation of the O allele. A pattern of low heterozygosity at the ABO locus where loss of polymorphism occurs in our model is consistent with small populations, such as Native American populations. This study provides a general evolutionary model to explain the observed global patterns of polymorphism at the ABO locus and the pattern of allele loss in small populations. Moreover, these results inform the range of population sizes associated with the recent human colonization of the Americas.

  11. Human Commercial Models' Eye Colour Shows Negative Frequency-Dependent Selection.

    Directory of Open Access Journals (Sweden)

    Isabela Rodrigues Nogueira Forti

    Full Text Available In this study we investigated the eye colour of human commercial models registered in the UK (400 female and 400 male and Brazil (400 female and 400 male to test the hypothesis that model eye colour frequency was the result of negative frequency-dependent selection. The eye colours of the models were classified as: blue, brown or intermediate. Chi-square analyses of data for countries separated by sex showed that in the United Kingdom brown eyes and intermediate colours were significantly more frequent than expected in comparison to the general United Kingdom population (P<0.001. In Brazil, the most frequent eye colour brown was significantly less frequent than expected in comparison to the general Brazilian population. These results support the hypothesis that model eye colour is the result of negative frequency-dependent selection. This could be the result of people using eye colour as a marker of genetic diversity and finding rarer eye colours more attractive because of the potential advantage more genetically diverse offspring that could result from such a choice. Eye colour may be important because in comparison to many other physical traits (e.g., hair colour it is hard to modify, hide or disguise, and it is highly polymorphic.

  12. Models of frequency-dependent selection with mutation from parental alleles.

    Science.gov (United States)

    Trotter, Meredith V; Spencer, Hamish G

    2013-09-01

    Frequency-dependent selection (FDS) remains a common heuristic explanation for the maintenance of genetic variation in natural populations. The pairwise-interaction model (PIM) is a well-studied general model of frequency-dependent selection, which assumes that a genotype's fitness is a function of within-population intergenotypic interactions. Previous theoretical work indicated that this type of model is able to sustain large numbers of alleles at a single locus when it incorporates recurrent mutation. These studies, however, have ignored the impact of the distribution of fitness effects of new mutations on the dynamics and end results of polymorphism construction. We suggest that a natural way to model mutation would be to assume mutant fitness is related to the fitness of the parental allele, i.e., the existing allele from which the mutant arose. Here we examine the numbers and distributions of fitnesses and alleles produced by construction under the PIM with mutation from parental alleles and the impacts on such measures due to different methods of generating mutant fitnesses. We find that, in comparison with previous results, generating mutants from existing alleles lowers the average number of alleles likely to be observed in a system subject to FDS, but produces polymorphisms that are highly stable and have realistic allele-frequency distributions.

  13. Human Commercial Models' Eye Colour Shows Negative Frequency-Dependent Selection.

    Science.gov (United States)

    Forti, Isabela Rodrigues Nogueira; Young, Robert John

    2016-01-01

    In this study we investigated the eye colour of human commercial models registered in the UK (400 female and 400 male) and Brazil (400 female and 400 male) to test the hypothesis that model eye colour frequency was the result of negative frequency-dependent selection. The eye colours of the models were classified as: blue, brown or intermediate. Chi-square analyses of data for countries separated by sex showed that in the United Kingdom brown eyes and intermediate colours were significantly more frequent than expected in comparison to the general United Kingdom population (PBrazilian population. These results support the hypothesis that model eye colour is the result of negative frequency-dependent selection. This could be the result of people using eye colour as a marker of genetic diversity and finding rarer eye colours more attractive because of the potential advantage more genetically diverse offspring that could result from such a choice. Eye colour may be important because in comparison to many other physical traits (e.g., hair colour) it is hard to modify, hide or disguise, and it is highly polymorphic.

  14. Frequency Tuning of IR First-Overtone CO Laser Radiation by Diffraction Grating and Frequency Selective Output Couplers

    National Research Council Canada - National Science Library

    Ionin, Andre

    1999-01-01

    ...: The contractor will investigate, both experimentally and theoretically, the feasibility of frequency tuning the first overtone carbon monoxide laser radiation by the use of diffraction gratings...

  15. Adaptive antenna selection and Tx/Rx beamforming for large-scale MIMO systems in 60 GHz channels

    Directory of Open Access Journals (Sweden)

    Prasad Narayan

    2011-01-01

    Full Text Available Abstract We consider a large-scale MIMO system operating in the 60 GHz band employing beamforming for high-speed data transmission. We assume that the number of RF chains is smaller than the number of antennas, which motivates the use of antenna selection to exploit the beamforming gain afforded by the large-scale antenna array. However, the system constraint that at the receiver, only a linear combination of the receive antenna outputs is available, which together with the large dimension of the MIMO system makes it challenging to devise an efficient antenna selection algorithm. By exploiting the strong line-of-sight property of the 60 GHz channels, we propose an iterative antenna selection algorithm based on discrete stochastic approximation that can quickly lock onto a near-optimal antenna subset. Moreover, given a selected antenna subset, we propose an adaptive transmit and receive beamforming algorithm based on the stochastic gradient method that makes use of a low-rate feedback channel to inform the transmitter about the selected beams. Simulation results show that both the proposed antenna selection and the adaptive beamforming techniques exhibit fast convergence and near-optimal performance.

  16. Investigation of frequency-selective properties of microwave wideband bandpass filters

    Science.gov (United States)

    Khodenkov, S. A.; Boev, N. M.

    2017-11-01

    A new approach allowing to improve frequency-selective properties for a fixed order of N filter is suggested. In all the studies, conducted with the help of numerical electrodynamic analysis of 3D models of microstrip filters based on a multimode resonator, the same substrate with dielectric constant ε=2.8 and thickness h=2 mm (material - FLAN) was used in calculations. The central bandpass frequency of microwave structures f 0≈1.4 GHz was registered and as well as relative bandwidth Δf/f o≈80%. The strip conductor of central multimode resonator in six studied filters of the sixth and eighth orders has the shape of an irregular meander being electromagnetically connected with four single-mode resonators, a pair of which is located to the left of it, and the other pair is to the right. It is shown that in single-mode quarter-wave resonators building-up the number of portions of identical parallel strip conductors, connected to a screen at one end and connected with each other by a strip conductor jumper, can increase the power of suppression at low-frequency stop band by more than 15 dB, as well as near high-frequency slope of passband by more than 10 dB. Therefore, the level of maximums of return losses in the passband of wideband bandpass filter ranges within a few dB.

  17. Selective Dirac voltage engineering of individual graphene field-effect transistors for digital inverter and frequency multiplier integrations.

    Science.gov (United States)

    Sul, Onejae; Kim, Kyumin; Jung, Yungwoo; Choi, Eunsuk; Lee, Seung-Beck

    2017-09-15

    The ambipolar band structure of graphene presents unique opportunities for novel electronic device applications. A cycle of gate voltage sweep in a conventional graphene transistor produces a frequency-doubled output current. To increase the frequency further, we used various graphene doping control techniques to produce Dirac voltage engineered graphene channels. The various surface treatments and substrate conditions produced differently doped graphene channels that were integrated on a single substrate and multiple Dirac voltages were observed by applying a single gate voltage sweep. We applied the Dirac voltage engineering techniques to graphene field-effect transistors on a single chip for the fabrication of a frequency multiplier and a logic inverter demonstrating analog and digital circuit application possibilities.

  18. Low-Frequency Noise Characterization of Ultra-shallow Gate N-channel Junction Field Effect Transistors

    NARCIS (Netherlands)

    Piccolo, G.; Sarubbi, F.; Vandamme, L.J.K.; Macucci, M.; Scholtes, T.L.M.; Nanver, Lis Karen

    2007-01-01

    A recently developed technique for ultra shallow pn junction formation has been applied for the fabrication of ring-gate n-channel junction field effect devices (JFET) devices. Several different geometries, gate formation parameters and channel doping profiles have been realized and characterized

  19. Passive Frequency Selective Surface Array as a Diffuser for Destroying Millimeter Wave Coherence

    Directory of Open Access Journals (Sweden)

    Saiful Islam

    2008-01-01

    Full Text Available This paper presents the design, construction, and testing of grounded frequency selective surface (FSS array as a diffuser for destroying millimeter wave coherence which is used to eliminate speckle in active millimeter wave imaging. To create stochastically independent illumination patterns, we proposed a diffuser based on random-phase distributions obtained by changing the incident frequency. The random-phase diffuser was obtained by mixing up the phase relations between the cells of a deterministic function (e.g., beam splitter. The slot length of FSS is the main design parameter used to optimize the phase shifting properties of the array. The critical parameters of the diffuser array design, such as phase relation with slot lengths, losses, and bandwidth, are discussed. We designed the FSS arrays with finite integral technique (FIT, fabricated by etching technique, and characterized the S-parameters with a free-space MVNA, and measured the radiation patterns with a BWO in motorized setup.

  20. Varactor-tunable frequency selective surface with an embedded bias network

    International Nuclear Information System (INIS)

    Lin Bao-Qin; Zhang Heng-Yang; Li Wei; Qu Shao-Bo; Tong Chuang-Ming; Zhou Hang

    2013-01-01

    A new technique for designing a varactor-tunable frequency selective surface (FSS) with an embedded bias network is proposed and experimentally verified. The proposed FSS is based on a square-ring slot FSS. The frequency tuning is achieved by inserting varactor diodes between the square mesh and each unattached square patch. The square mesh is divided into two parts for biasing the varactor diodes. Full-wave numerical simulations show that a wide tuning range can be achieved by changing the capacitances of these loaded varactors. Two homo-type samples using fixed lumped capacitors are fabricated and measured using a standard waveguide measurement setup. Excellent agreement between the measured and simulated results is demonstrated. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  1. A practical double-sided frequency selective surface for millimeter-wave applications

    Science.gov (United States)

    Mohyuddin, Wahab; Woo, Dong Sik; Choi, Hyun Chul; Kim, Kang Wook

    2018-02-01

    Analysis, design, and implementation of a practical, high-rejection frequency selective surface (FSS) are presented in this paper. An equivalent circuit model is introduced for predicting the frequency response of the FSS. The FSS consists of periodic square loop structures fabricated on both sides of the thin dielectric substrate by using the low-cost chemical etching technique. The proposed FSS possesses band-stop characteristics and is implemented to suppress the 170 GHz signal with attenuation of more than 45 dB with insensitivity to an angle of incident plane wave over 20°. Good agreement is observed among calculated, simulated, and measured results. The proposed FSS filter can be used in various millimeter-wave applications such as the protection of imaging diagnostic systems from high spurious input power.

  2. Fine-structure processing, frequency selectivity and speech perception in hearing-impaired listeners

    DEFF Research Database (Denmark)

    Strelcyk, Olaf; Dau, Torsten

    2008-01-01

    Hearing-impaired people often experience great difficulty with speech communication when background noise is present, even if reduced audibility has been compensated for. Other impairment factors must be involved. In order to minimize confounding effects, the subjects participating in this study...... modulation were obtained. In addition, these binaural and monaural thresholds were measured in a stationary background noise in order to assess the persistence of the fine-structure processing to interfering noise. Apart from elevated speech reception thresholds, the hearing impaired listeners showed poorer...... performance than the normally hearing in terms of frequency selectivity and fine-structure processing, despite normal audiometric thresholds at the test frequencies. However, the binaural fine-structure processing was not found to be particularly vulnerable to interfering noise in these listeners....

  3. Analytical Solution for Elliptical Cloaks Based on The Frequency Selective Surface

    Directory of Open Access Journals (Sweden)

    E. Ghasemi Mizuji

    2015-01-01

    Full Text Available In this paper the elliptical dielectric cylinder which is covered with FSS cloak is considered. Frequency selective surface cloak which Alu named it mantle cloak is one of the recent techniques for cloaking. In this method an appropriate FSS can act as cloaking device for suppressing  the scattering of object  in the desired frequency. With using this method the dimension of the cloaks is extremely reduced. By this proposed structure, the RCS of elliptical cylinder  is reduced about 10-20 dB and designed cloak has an appropriate performance.  The analytical solution for the wave in each layer is presented and with using simulation, the electric field and the scattering pattern has been drawn.

  4. Evaluation of habitat quality for selected wildlife species associated with back channels.

    Science.gov (United States)

    Anderson, James T.; Zadnik, Andrew K.; Wood, Petra Bohall; Bledsoe, Kerry

    2013-01-01

    The islands and associated back channels on the Ohio River, USA, are believed to provide critical habitat features for several wildlife species. However, few studies have quantitatively evaluated habitat quality in these areas. Our main objective was to evaluate the habitat quality of back and main channel areas for several species using habitat suitability index (HSI) models. To test the effectiveness of these models, we attempted to relate HSI scores and the variables measured for each model with measures of relative abundance for the model species. The mean belted kingfisher (Ceryle alcyon) HSI was greater on the main than back channel. However, the model failed to predict kingfisher abundance. The mean reproduction component of the great blue heron (Ardea herodias) HSI, total common muskrat (Ondatra zibethicus) HSI, winter cover component of the snapping turtle (Chelydra serpentina) HSI, and brood-rearing component of the wood duck (Aix sponsa) HSI were all greater on the back than main channel, and were positively related with the relative abundance of each species. We found that island back channels provide characteristics not found elsewhere on the Ohio River and warrant conservation as important riparian wildlife habitat. The effectiveness of using HSI models to predict species abundance on the river was mixed. Modifications to several of the models are needed to improve their use on the Ohio River and, likely, other large rivers.

  5. Selective spleen scintigraphy to evaluate frequency of splenosis after posttraumatic splenectomy

    International Nuclear Information System (INIS)

    Loew, A.; Tischler, E.; Mahlstedt, J.; Wolf, F.; Meier, H.

    1981-01-01

    In 60 patients having had posttraumatic splenectomy between 9 months and 12 years ago frequency of splenosis was investigated in comparison to immunological and hematological parameters. Selective spleen scintigraphy was performed with sup(99m)-Tc-labelled heat-damaged auto-erythrocytes. In 46,7% of the patients splenosis was found without age dependence. Between patients with and without splenosis no significant differences concerning the immunological and hematological parameters were seen. Therefore, the lack of pathological manifestations after posttraumatic splenectomy is not to be related to autotransplantation of splenic tissue. (orig.) [de

  6. Millimeter Wave Systems for Airports and Short-Range Aviation Communications: A Survey of the Current Channel Models at mmWave Frequencies

    Science.gov (United States)

    Khatun, Mahfuza; Mehrpouyan, Hani; Matolak, David; Guvenc, Ismail

    2017-01-01

    Millimeter-wave (mmWave) communications will play a key role in enhancing the throughput, reliability, and security of next generation wireless networks. These advancements are achieved through the large bandwidth available in this band and through the use of highly directional links that will be used to overcome the large pathloss at these frequencies. Although the terrestrial application of mmWave systems is advancing at a rapid pace, the use of mmWave communication systems in aviation systems or airports is still in its infancy. This can be attributed to the challenges related to radio technology and lack of development, and characterization of mmWave wireless channels for the aviation field and the airport environment. Consequently, one of our goals is to develop methodologies that support mmWave air to ground links, and various links at airports, by applying new localization schemes that allow for application of highly directional links that can be deployed over longer distances despite the high path loss at mmWave frequencies. However, a very thorough understanding of the mmWave channel models are needed to enable such new applications. To this end, in this paper, we present a survey of the current channel models in the mmWave band. The 3-dimensional statistical channel model is also reviewed and its parameters and typical characteristics for this model are identified and computed through simulation for the Boise metropolitan area.

  7. A Novel Partial Discharge Ultra-High Frequency Signal De-Noising Method Based on a Single-Channel Blind Source Separation Algorithm

    Directory of Open Access Journals (Sweden)

    Liangliang Wei

    2018-02-01

    Full Text Available To effectively de-noise the Gaussian white noise and periodic narrow-band interference in the background noise of partial discharge ultra-high frequency (PD UHF signals in field tests, a novel de-noising method, based on a single-channel blind source separation algorithm, is proposed. Compared with traditional methods, the proposed method can effectively de-noise the noise interference, and the distortion of the de-noising PD signal is smaller. Firstly, the PD UHF signal is time-frequency analyzed by S-transform to obtain the number of source signals. Then, the single-channel detected PD signal is converted into multi-channel signals by singular value decomposition (SVD, and background noise is separated from multi-channel PD UHF signals by the joint approximate diagonalization of eigen-matrix method. At last, the source PD signal is estimated and recovered by the l1-norm minimization method. The proposed de-noising method was applied on the simulation test and field test detected signals, and the de-noising performance of the different methods was compared. The simulation and field test results demonstrate the effectiveness and correctness of the proposed method.

  8. Baseline Channel Geometry and Aquatic Habitat Data for Selected Streams in the Matanuska-Susitna Valley, Alaska

    Science.gov (United States)

    Curran, Janet H.; Rice, William J.

    2009-01-01

    Small streams in the rapidly developing Matanuska-Susitna Valley in south-central Alaska are known to support anadromous and resident fish but little is known about their hydrologic and riparian conditions, or their sensitivity to the rapid development of the area or climate variability. To help address this need, channel geometry and aquatic habitat data were collected in 2005 as a baseline of stream conditions for selected streams. Three streams were selected as representative of various stream types, and one drainage network, the Big Lake drainage basin, was selected for a systematic assessment. Streams in the Big Lake basin were drawn in a Geographic Information System (GIS), and 55 reaches along 16 miles of Meadow Creek and its primary tributary Little Meadow Creek were identified from orthoimagery and field observations on the basis of distinctive physical and habitat parameters, most commonly gradient, substrate, and vegetation. Data-collection methods for sites at the three representative reaches and the 55 systematically studied reaches consisted of a field survey of channel and flood-plain geometry and collection of 14 habitat attributes using published protocols or slight modifications. Width/depth and entrenchment ratios along the Meadow-Little Meadow Creek corridor were large and highly variable upstream of Parks Highway and lower and more consistent downstream of Parks Highway. Channel width was strongly correlated with distance, increasing downstream in a log-linear relation. Runs formed the most common habitat type, and instream vegetation dominated the habitat cover types, which collectively covered 53 percent of the channel. Gravel suitable for spawning covered isolated areas along Meadow Creek and about 29 percent of Little Meadow Creek. Broad wetlands were common along both streams. For a comprehensive assessment of small streams in the Mat-Su Valley, critical additional data needs include hydrologic, geologic and geomorphic, and biologic data

  9. Harnessing mode-selective nonlinear optics for on-chip multi-channel all-optical signal processing

    Directory of Open Access Journals (Sweden)

    Ming Ma

    2016-11-01

    Full Text Available All-optical signal processing based on nonlinear optical effects allows for the realization of important functions in telecommunications including wavelength conversion, optical multiplexing/demultiplexing, Fourier transformation, and regeneration, amongst others, on ultrafast time scales to support high data rate transmission. In integrated photonic subsystems, the majority of all-optical signal processing systems demonstrated to date typically process only a single channel at a time or perform a single processing function, which imposes a serious limitation on the functionality of integrated solutions. Here, we demonstrate how nonlinear optical effects can be harnessed in a mode-selective manner to perform simultaneous multi-channel (two and multi-functional optical signal processing (i.e., regenerative wavelength conversion in an integrated silicon photonic device. This approach, which can be scaled to a higher number of channels, opens up a new degree of freedom for performing a broad range of multi-channel nonlinear optical signal processing functions using a single integrated photonic device.

  10. Inhibition of T cell proliferation by selective block of Ca(2+)-activated K(+) channels

    DEFF Research Database (Denmark)

    Jensen, B S; Odum, Niels; Jorgensen, N K

    1999-01-01

    cell activation and proliferation has been investigated by using various blockers of IK channels. The Ca(2+)-activated K(+) current in human T cells is shown by the whole-cell voltage-clamp technique to be highly sensitive to clotrimazole, charybdotoxin, and nitrendipine, but not to ketoconazole...

  11. Control of the selectivity of the aquaporin water channel family by global orientational tuning

    DEFF Research Database (Denmark)

    Jensen, Morten Østergaard; Tajkhorshid, E.; Nollert, P.

    2002-01-01

    and orientation of a single file of seven to nine water molecules inside the channel. Two conserved asparagines force a central water molecule to serve strictly as a hydrogen bond donor to its neighboring water molecules. Assisted by the electrostatic potential generated by two half-membrane spanning loops...

  12. Video error concealment using block matching and frequency selective extrapolation algorithms

    Science.gov (United States)

    P. K., Rajani; Khaparde, Arti

    2017-06-01

    Error Concealment (EC) is a technique at the decoder side to hide the transmission errors. It is done by analyzing the spatial or temporal information from available video frames. It is very important to recover distorted video because they are used for various applications such as video-telephone, video-conference, TV, DVD, internet video streaming, video games etc .Retransmission-based and resilient-based methods, are also used for error removal. But these methods add delay and redundant data. So error concealment is the best option for error hiding. In this paper, the error concealment methods such as Block Matching error concealment algorithm is compared with Frequency Selective Extrapolation algorithm. Both the works are based on concealment of manually error video frames as input. The parameter used for objective quality measurement was PSNR (Peak Signal to Noise Ratio) and SSIM(Structural Similarity Index). The original video frames along with error video frames are compared with both the Error concealment algorithms. According to simulation results, Frequency Selective Extrapolation is showing better quality measures such as 48% improved PSNR and 94% increased SSIM than Block Matching Algorithm.

  13. On the performance of arbitrary transmit selection for threshold-based receive MRC with and without co-channel interference

    KAUST Repository

    Radaydeh, Redha Mahmoud Mesleh

    2011-11-01

    The performance of multiple-antenna diversity systems in which the receiver combines signal replicas per threshold-based maximal ratio combining (MRC) and transmitter uses only a single antenna according to receive combined signal strength is studied. The impact of imperfect channel estimation and the effect of phase and time misalignments between desired and undesired signals are implicitly investigated. It is assumed that the desired signal replicas and interfering signals undergo statistically independent flat Rayleigh fading. The analysis is applicable for arbitrary transmit antenna selection, based either on receive combined signal-to-noise ratio (SNR) or receive combined signal-to-interference-plus-noise ratio (SINR). For the scenario of identical multiple-antenna channels, closed-form analytical results for the combined SNR statistics and some performance measures are first presented. The SNR-based and SINR-based selection algorithms are then employed to obtain expressions for the distribution of combined SINR and outage probability performance, which are applicable for different statistical models of interfering signals. The adopted system models herein as well as the analytical development add enhancements on many existing results, and can be used to study the performance of different architectures under various channel conditions when the implementation complexity is of interest. © 2011 IEEE.

  14. Whether and How to Select Inertia and Acceleration of Discrete Particle Swarm Optimization Algorithm: A Study on Channel Assignment

    Directory of Open Access Journals (Sweden)

    Min Jin

    2014-01-01

    Full Text Available There is recently a great deal of interest and excitement in understanding the role of inertia and acceleration in the motion equation of discrete particle swarm optimization (DPSO algorithms. It still remains unknown whether the inertia section should be abandoned and how to select the appropriate acceleration in order for DPSO to show the best convergence performance. Adopting channel assignment as a case study, this paper systematically conducts experimental filtering research on this issue. Compared with other channel assignment schemes, the proposed scheme and the selection of inertia and acceleration are verified to have the advantage to channel assignment in three respects of convergence rate, convergence speed, and the independency of the quality of initial solution. Furthermore, the experimental result implies that DSPO might have the best convergence performance when its motion equation includes an inertia section in a less medium weight, a bigger acceleration coefficient for global-search optimum, and a smaller acceleration coefficient for individual-search optimum.

  15. Switches of stimulus tagging frequencies interact with the conflict-driven control of selective attention, but not with inhibitory control.

    Science.gov (United States)

    Scherbaum, Stefan; Frisch, Simon; Dshemuchadse, Maja

    2016-01-01

    Selective attention and its adaptation by cognitive control processes are considered a core aspect of goal-directed action. Often, selective attention is studied behaviorally with conflict tasks, but an emerging neuroscientific method for the study of selective attention is EEG frequency tagging. It applies different flicker frequencies to the stimuli of interest eliciting steady state visual evoked potentials (SSVEPs) in the EEG. These oscillating SSVEPs in the EEG allow tracing the allocation of selective attention to each tagged stimulus continuously over time. The present behavioral investigation points to an important caveat of using tagging frequencies: The flicker of stimuli not only produces a useful neuroscientific marker of selective attention, but interacts with the adaptation of selective attention itself. Our results indicate that RT patterns of adaptation after response conflict (so-called conflict adaptation) are reversed when flicker frequencies switch at once. However, this effect of frequency switches is specific to the adaptation by conflict-driven control processes, since we find no effects of frequency switches on inhibitory control processes after no-go trials. We discuss the theoretical implications of this finding and propose precautions that should be taken into account when studying conflict adaptation using frequency tagging in order to control for the described confounds. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg2+ channel MgtE.

    Science.gov (United States)

    Takeda, Hironori; Hattori, Motoyuki; Nishizawa, Tomohiro; Yamashita, Keitaro; Shah, Syed T A; Caffrey, Martin; Maturana, Andrés D; Ishitani, Ryuichiro; Nureki, Osamu

    2014-11-04

    Magnesium is the most abundant divalent cation in living cells and is crucial to several biological processes. MgtE is a Mg(2+) channel distributed in all domains of life that contributes to the maintenance of cellular Mg(2+) homeostasis. Here we report the high-resolution crystal structures of the transmembrane domain of MgtE, bound to Mg(2+), Mn(2+) and Ca(2+). The high-resolution Mg(2+)-bound crystal structure clearly visualized the hydrated Mg(2+) ion within its selectivity filter. Based on those structures and biochemical analyses, we propose a cation selectivity mechanism for MgtE in which the geometry of the hydration shell of the fully hydrated Mg(2+) ion is recognized by the side-chain carboxylate groups in the selectivity filter. This is in contrast to the K(+)-selective filter of KcsA, which recognizes a dehydrated K(+) ion. Our results further revealed a cation-binding site on the periplasmic side, which regulate channel opening and prevents conduction of near-cognate cations.

  17. Analysis of channel confined selective area growth in evolutionary growth of GaN on SiO 2

    Energy Technology Data Exchange (ETDEWEB)

    Leung, Benjamin; Tsai, Miao-Chan; Song, Jie; Zhang, Yu; Xiong, Kanglin; Yuan, Ge; Coltrin, Michael E.; Han, Jung

    2015-09-01

    Here, we analyze the chemical vapor deposition of semiconductor crystals by selective area growth in a non-planar geometry. Specifically, the growth process in laterally and vertically confined masks forming single-crystal GaN on SiO2 by metal-organic chemical vapor deposition is considered in detail. A textured AlN seed is used to initiate growth of oriented GaN selectively through the mask, allowing the reduction of degrees of freedom by the evolutionary grain selection process. As shown by measurements of growth rates within the mask, the sub micron length scale of the channel opening is comparable to the mean free path of precursors in the gas phase, resulting in transport characteristics that can be described by an intermediate flow regime between continuum and free-molecular. Mass transport is modeled through kinetic theory to explain the growth rate enhancements of more than a factor of two by changes in reactor pressure. The growth conditions that enable the modification of nucleation density within the channel are then discussed, and are measured by electron-back scatter diffraction of the nucleated grains on the AlN seed. Finally, the selectivity behavior using the low fill factor masks needed in these configurations has been optimized by control of precursor flow rates and the H2 enhanced etching of the polycrystalline GaN nuclei.

  18. Retail Deli Slicer Cleaning Frequency--Six Selected Sites, United States, 2012.

    Science.gov (United States)

    Brown, Laura G; Hoover, E Rickamer; Ripley, Danny; Matis, Bailey; Nicholas, David; Hedeen, Nicole; Faw, Brenda

    2016-04-01

    Listeria monocytogenes (Listeria) causes the third highest number of foodborne illness deaths (an estimated 255) in the United States annually, after nontyphoidal Salmonella species and Toxoplasma gondii (1). Deli meats are a major source of listeriosis illnesses, and meats sliced and packaged at retail delis are the major source of listeriosis illnesses attributed to deli meat (4). Mechanical slicers pose cross-contamination risks in delis and are an important source of Listeria cross-contamination. Reducing Listeria contamination of sliced meats in delis will likely reduce Listeria illnesses and outbreaks. Good slicer cleaning practices can reduce this foodborne illness risk. CDC's Environmental Health Specialists Network (EHS-Net) studied how often retail deli slicers were fully cleaned (disassembled, cleaned, and sanitized) at the Food and Drug Administration (FDA) Food Code-specified minimum frequency of every 4 hours and examined deli and staff characteristics related to slicer cleaning frequency. Interviews with staff members in 298 randomly-selected delis in six EHS-Net sites showed that approximately half of delis fully cleaned their slicers less often than FDA's specified minimum frequency. Chain-owned delis and delis with more customers, more slicers, required manager food safety training, food safety-knowledgeable workers, written slicer-cleaning policies, and food safety-certified managers fully cleaned their slicers more frequently than did other types of delis, according to deli managers or workers. States and localities should require deli manager training and certification, as specified in the FDA Food Code. They should also consider encouraging or requiring delis to have written slicer-cleaning policies. Retail food industry leaders can also implement these prevention efforts to reduce risk in their establishments. Because independent and smaller delis had lower frequencies of slicer cleaning, prevention efforts should focus on these types of

  19. Effects of unsaturated fatty acids on torpor frequency and diet selection in Djungarian hamsters (Phodopus sungorus).

    Science.gov (United States)

    Diedrich, Victoria; Steinlechner, Stephan; Scherbarth, Frank

    2014-12-15

    Essential polyunsaturated fatty acids (PUFA) have been shown to play a beneficial role in hibernating mammals. High amounts of dietary PUFA led to an earlier hibernation onset, deeper and longer hibernation bouts and a higher proportion of hibernating animals in several species. In contrast, the relevance of dietary PUFA for daily heterotherms exhibiting only brief and shallow torpor bouts is less well studied. Therefore, diets differing in PUFA composition were used to examine the effects on the frequency of spontaneous daily torpor in Djungarian hamsters (Phodopus sungorus). In contrast to earlier studies, we were interested in whether the ratio of n-6 to n-3 PUFA affects torpor expression, and in comparison with a diet rich in monounsaturated fatty acids (MUFA). Although we found a positive effect on torpor frequency in hamsters fed a diet rich in n-6 PUFA compared with the groups fed diets either rich in n-3 PUFA or MUFA, the latter two groups did not show unusually low torpor frequencies. The results of the additional diet choice experiment indicated that hamsters in short photoperiod select food with only a slight excess of n-6 PUFA compared with n-3 PUFA (ratio of 1 to 1.5). However, there was no significant difference in torpor frequency between the diet choice group and hamsters fed on standard chow with a sevenfold excess of n-6 PUFA. In summary, the present data strongly indicate that the dietary composition of unsaturated fatty acids plays a minor role in the occurrence of spontaneous daily torpor in Djungarian hamsters. © 2014. Published by The Company of Biologists Ltd.

  20. The performance analysis of Islamic republic of Iran broadcasting (IRIB in comparison with foreign selected channels in the field of sports

    Directory of Open Access Journals (Sweden)

    Mostafa Moghadas

    2017-12-01

    Full Text Available  The purpose of this study was to analyze the performance of Islamic republic of Iran broadcasting (IRIB in comparison with foreign selected channels in the field of sports. The methodology of the present study is descriptive in terms of strategy and content analysis in terms of method. The statistical population of the study includes all channels that are involved in production of sport programs inside and outside of the country. Two non-sport channels and two sport channels that covered night and day sport events were selected as the samples of the study. The Tv3 channel and Sport Channel from Iran and ZDF and Ray Sport 1 channel from Germany have been selected as the samples for the test. The instrument used for data collection in this study was coded sheet used for analyzing the content of the programs broadcasting by these channels. Face and content validity of coded sheet confirmed by three experts and its reliability confirmed by agreement coefficient of Scott π (0/86. The results of the study showed that different TV channels in terms of content, function and coverage of sport programs are different based on functional roles. Therefore, broadcasting organization must develop comprehensive and codified programming for broadcasting sport programs and its coverage.

  1. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.

    Science.gov (United States)

    Swale, Daniel R; Kurata, Haruto; Kharade, Sujay V; Sheehan, Jonathan; Raphemot, Rene; Voigtritter, Karl R; Figueroa, Eric E; Meiler, Jens; Blobaum, Anna L; Lindsley, Craig W; Hopkins, Corey R; Denton, Jerod S

    2016-07-20

    The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) has recently emerged as a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy. The pharmacological tools available for exploring the physiology and therapeutic potential of Kir7.1 have been limited to relatively weak and nonselective small-molecule inhibitors. Here, we report the discovery in a fluorescence-based high-throughput screen of a novel Kir7.1 channel inhibitor, VU714. Site-directed mutagenesis of pore-lining amino acid residues identified glutamate 149 and alanine 150 as essential determinants of VU714 activity. Lead optimization with medicinal chemistry generated ML418, which exhibits sub-micromolar activity (IC50 = 310 nM) and superior selectivity over other Kir channels (at least 17-fold selective over Kir1.1, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2, and Kir4.1) except for Kir6.2/SUR1 (equally potent). Evaluation in the EuroFins Lead Profiling panel of 64 GPCRs, ion-channels, and transporters for off-target activity of ML418 revealed a relatively clean ancillary pharmacology. While ML418 exhibited low CLHEP in human microsomes which could be modulated with lipophilicity adjustments, it showed high CLHEP in rat microsomes regardless of lipophilicity. A subsequent in vivo PK study of ML418 by intraperitoneal (IP) administration (30 mg/kg dosage) revealed a suitable PK profile (Cmax = 0.20 μM and Tmax = 3 h) and favorable CNS distribution (mouse brain/plasma Kp of 10.9 to support in vivo studies. ML418, which represents the current state-of-the-art in Kir7.1 inhibitors, should be useful for exploring the physiology of Kir7.1 in vitro and in vivo.

  2. Capacity bounds for kth best path selection over generalized fading channels

    KAUST Repository

    Hanif, Muhammad Fainan

    2014-02-01

    Exact ergodic capacity calculation for fading wireless channels typically involves time-consuming numerical evaluation of infinite integrals. In this paper, lower and upper bounds on ergodic capacity for kth best path are presented. These bounds have simple analytic expressions which allow their fast evaluation. Numerical results show that the newly proposed bounds closely approximate the exact ergodic capacity for a large variety of system configurations. © 1997-2012 IEEE.

  3. Host population structure and treatment frequency maintain balancing selection on drug resistance

    Science.gov (United States)

    Baskerville, Edward B.; Colijn, Caroline; Hanage, William; Fraser, Christophe; Lipsitch, Marc

    2017-01-01

    It is a truism that antimicrobial drugs select for resistance, but explaining pathogen- and population-specific variation in patterns of resistance remains an open problem. Like other common commensals, Streptococcus pneumoniae has demonstrated persistent coexistence of drug-sensitive and drug-resistant strains. Theoretically, this outcome is unlikely. We modelled the dynamics of competing strains of S. pneumoniae to investigate the impact of transmission dynamics and treatment-induced selective pressures on the probability of stable coexistence. We find that the outcome of competition is extremely sensitive to structure in the host population, although coexistence can arise from age-assortative transmission models with age-varying rates of antibiotic use. Moreover, we find that the selective pressure from antibiotics arises not so much from the rate of antibiotic use per se but from the frequency of treatment: frequent antibiotic therapy disproportionately impacts the fitness of sensitive strains. This same phenomenon explains why serotypes with longer durations of carriage tend to be more resistant. These dynamics may apply to other potentially pathogenic, microbial commensals and highlight how population structure, which is often omitted from models, can have a large impact. PMID:28835542

  4. Improved CT-detection of acute bowel ischemia using frequency selective non-linear image blending.

    Science.gov (United States)

    Schneeweiss, Sven; Esser, Michael; Thaiss, Wolfgang; Boesmueller, Hans; Ditt, Hendrik; Nikolau, Konstantin; Horger, Marius

    2017-07-01

    Computed tomography (CT) as a fast and reliable diagnostic technique is the imaging modality of choice for acute bowel ischemia. However, diagnostic is often difficult mainly due to low attenuation differences between ischemic and perfused segments. To compare the diagnostic efficacy of a new post-processing tool based on frequency selective non-linear blending with that of conventional linear contrast-enhanced CT (CECT) image blending for the detection of bowel ischemia. Twenty-seven consecutive patients (19 women; mean age = 73.7 years, age range = 50-94 years) with acute bowel ischemia were scanned using multidetector CT (120 kV; 100-200 mAs). Pre-contrast and portal venous scans (65-70 s delay) were acquired. All patients underwent surgery for acute bowel ischemia and intraoperative diagnosis as well as histologic evaluation of explanted bowel segments was considered "gold standard." First, two radiologists read the conventional CECT images in which linear blending was adapted for optimal contrast, and second (three weeks later) the frequency selective non-linear blending (F-NLB) image. Attenuation values were compared, both in the involved and non-involved bowel segments creating ratios between unenhanced and CECT. The mean attenuation difference between ischemic and non-ischemic wall in the portal venous scan was 69.54 HU (reader 2 = 69.01 HU) higher for F-NLB compared with conventional CECT. Also, the attenuation ratio between contrast-enhanced and pre-contrast CT data for the non-ischemic walls showed significantly higher values for the F-NLB image (CECT: reader 1 = 2.11 (reader 2 = 3.36), F-NLB: reader 1 = 4.46 (reader 2 = 4.98)]. Sensitivity in detecting ischemic areas increased significantly for both readers using F-NLB (CECT: reader 1/2 = 53%/65% versus F-NLB: reader 1/2 = 62%/75%). Frequency selective non-linear blending improves detection of bowel ischemia compared with conventional CECT by increasing

  5. On Secrecy Outage of Relay Selection in Underlay Cognitive Radio Networks over Nakagami-m Fading Channels

    KAUST Repository

    Lei, Hongjiang

    2017-10-02

    In this paper, the secrecy outage performance of an underlay cognitive decode-and-forward relay network over independent but not necessarily identical distributed (i.n.i.d) Nakagami-m fading channels is investigated, in which the secondary user transmitter communicates with the secondary destination via relays, and an eavesdropper attempts to overhear the information. Based on whether the channel state information (CSI) of the wiretap links is available or not, we analyze the secrecy outage performance with optimal relay selection (ORS) and suboptimal relay selection (SRS) schemes, and multiple relays combining scheme (MRC) scheme is considered for comparison purpose. The exact and asymptotic closed-form expressions for the secrecy outage probability with three different relay selection schemes are derived and verified by Monte-Carlo simulations. The numerical results illustrate that ORS scheme always outperforms SRS and MRC schemes, and SRS scheme is better than MRC scheme in the lower fading parameters scenario. Furthermore, through asymptotic analysis, we find that these three different schemes achieve the same secrecy diversity order, which is determined by the number of the relays, and the fading parameters of the links among the relays and the destination.

  6. Dynamics of ions in the selectivity filter of the KcsA channel: Towards a coupled Brownian particle description

    OpenAIRE

    Cosseddu, Salvatore M.; Khovanov, Igor A.; Allen, Michael P.; Rodger, P. M.; Luchinsky, Dmitry G.; McClintock, Peter V. E.

    2013-01-01

    The statistical and dynamical properties of ions in the selectivity filter of the KcsA ion channel are considered on the basis of molecular dynamics (MD) simulations of the KcsA protein embedded in a lipid membrane surrounded by an ionic solution. A new approach to the derivation of a Brownian dynamics (BD) model of ion permeation through the filter is discussed, based on unbiased MD simulations. It is shown that depending on additional assumptions, ion’s dynamics can be described either by u...

  7. Appropriate microwave frequency selection for biasing superconducting hot electron bolometers as terahertz direct detectors

    Science.gov (United States)

    Jiang, S. L.; Li, X. F.; Jia, X. Q.; Kang, L.; Jin, B. B.; Xu, W. W.; Chen, J.; Wu, P. H.

    2017-04-01

    Terahertz (THz) direct detectors based on superconducting niobium nitride (NbN) hot electron bolometers (HEBs) and biased by a simple microwave (MW) source have been studied. The frequency and power of the MW are selected by measuring the MW responses of the current-voltage (I-V) curves and resistance-temperature (R-T) curves of the NbN HEBs. The non-uniform absorption theory is used to explain the current jumps in the I-V curves and the resistance jumps in the R-T curves. Compared to the thermal biasing, the MW biasing method can improve the sensitivity, make the readout system much easier and consumes less liquid helium, which is important for long lasting experiments. The noise equivalent power (NEP) of 1.6 pW Hz-1/2 and the response time of 86 ps are obtained for the detectors working at 4.2 K and 0.65 THz.

  8. Sibling genes as environment: Sibling dopamine genotypes and adolescent health support frequency dependent selection.

    Science.gov (United States)

    Rauscher, Emily; Conley, Dalton; Siegal, Mark L

    2015-11-01

    While research consistently suggests siblings matter for individual outcomes, it remains unclear why. At the same time, studies of genetic effects on health typically correlate variants of a gene with the average level of behavioral or health measures, ignoring more complicated genetic dynamics. Using National Longitudinal Study of Adolescent Health data, we investigate whether sibling genes moderate individual genetic expression. We compare twin variation in health-related absences and self-rated health by genetic differences at three locations related to dopamine regulation and transport to test sibship-level cross-person gene-gene interactions. Results suggest effects of variation at these genetic locations are moderated by sibling genes. Although the mechanism remains unclear, this evidence is consistent with frequency dependent selection and suggests much genetic research may violate the stable unit treatment value assumption. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. A novel tunable frequency selective surface absorber with dual-DOF for broadband applications.

    Science.gov (United States)

    Kong, Peng; Yu, XiaoWei; Liu, ZhengYang; Zhou, Kai; He, Yun; Miao, Ling; Jiang, JianJun

    2014-12-01

    A novel tunable frequency selective surface (FSS) with dual-degrees of freedom (DOF) is presented, and firstly applied to broadband absorber. Based on a simple prototype unit cell resonator, an approach for achieving multi-resonances is studied. A unit cell pattern with gradient edges is discussed, and variable resistor and variable capacitor are introduced to fully utilize its characteristic of multi-resonances. Bias line is designed to provide bias voltage respectively for two variable devices and provide two operational DOF for FSS. Simulation and measurement results both show that the tunable FSS absorber with dual-DOF has wideband absorption with the reflectivity below -10 dB in 1-5 GHz and with a total thickness of about 10 mm.

  10. Effect of catchment properties and flood generation regime on copula selection for bivariate flood frequency analysis

    Science.gov (United States)

    Filipova, Valeriya; Lawrence, Deborah; Klempe, Harald

    2018-02-01

    Applying copula-based bivariate flood frequency analysis is advantageous because the results provide information on both the flood peak and volume. More data are, however, required for such an analysis, and it is often the case that only data series with a limited record length are available. To overcome this issue of limited record length, data regarding climatic and geomorphological properties can be used to complement statistical methods. In this paper, we present a study of 27 catchments located throughout Norway, in which we assess whether catchment properties, flood generation processes and flood regime have an effect on the correlation between flood peak and volume and, in turn, on the selection of copulas. To achieve this, the annual maximum flood events were first classified into events generated primarily by rainfall, snowmelt or a combination of these. The catchments were then classified into flood regime, depending on the predominant flood generation process producing the annual maximum flood events. A contingency table and Fisher's exact test were used to determine the factors that affect the selection of copulas in the study area. The results show that the two-parameter copulas BB1 and BB7 are more commonly selected in catchments with high steepness, high mean annual runoff and rainfall flood regime. These findings suggest that in these types of catchments, the dependence structure between flood peak and volume is more complex and cannot be modeled effectively using a one-parameter copula. The results illustrate that by relating copula types to flood regime and catchment properties, additional information can be supplied for selecting copulas in catchments with limited data.

  11. Low intensity and frequency pulsed electromagnetic fields selectively impair breast cancer cell viability.

    Directory of Open Access Journals (Sweden)

    Sara Crocetti

    Full Text Available INTRODUCTION: A common drawback of many anticancer therapies is non-specificity in action of killing. We investigated the potential of ultra-low intensity and frequency pulsed electromagnetic fields (PEMFs to kill breast cancer cells. Our criteria to accept this technology as a potentially valid therapeutic approach were: 1 cytotoxicity to breast cancer cells and; 2 that the designed fields proved innocuous to healthy cell classes that would be exposed to the PEMFs during clinical treatment. METHODS: MCF7 breast cancer cells and their normal counterparts, MCF10 cells, were exposed to PEMFs and cytotoxic indices measured in order to design PEMF paradigms that best kill breast cancer cells. The PEMF parameters tested were: 1 frequencies ranging from 20 to 50 Hz; 2 intensities ranging from 2 mT to 5 mT and; 3 exposure durations ranging from 30 to 90 minutes per day for up to three days to determine the optimum parameters for selective cancer cell killing. RESULTS: We observed a discrete window of vulnerability of MCF7 cells to PEMFs of 20 Hz frequency, 3 mT magnitude and exposure duration of 60 minutes per day. The cell damage accrued in response to PEMFs increased with time and gained significance after three days of consecutive daily exposure. By contrast, the PEMFs parameters determined to be most cytotoxic to breast cancer MCF-7 cells were not damaging to normal MCF-10 cells. CONCLUSION: Based on our data it appears that PEMF-based anticancer strategies may represent a new therapeutic approach to treat breast cancer without affecting normal tissues in a manner that is non-invasive and can be potentially combined with existing anti-cancer treatments.

  12. Low Intensity and Frequency Pulsed Electromagnetic Fields Selectively Impair Breast Cancer Cell Viability

    Science.gov (United States)

    Crocetti, Sara; Beyer, Christian; Schade, Grit; Egli, Marcel; Fröhlich, Jürg; Franco-Obregón, Alfredo

    2013-01-01

    Introduction A common drawback of many anticancer therapies is non-specificity in action of killing. We investigated the potential of ultra-low intensity and frequency pulsed electromagnetic fields (PEMFs) to kill breast cancer cells. Our criteria to accept this technology as a potentially valid therapeutic approach were: 1) cytotoxicity to breast cancer cells and; 2) that the designed fields proved innocuous to healthy cell classes that would be exposed to the PEMFs during clinical treatment. Methods MCF7 breast cancer cells and their normal counterparts, MCF10 cells, were exposed to PEMFs and cytotoxic indices measured in order to design PEMF paradigms that best kill breast cancer cells. The PEMF parameters tested were: 1) frequencies ranging from 20 to 50 Hz; 2) intensities ranging from 2 mT to 5 mT and; 3) exposure durations ranging from 30 to 90 minutes per day for up to three days to determine the optimum parameters for selective cancer cell killing. Results We observed a discrete window of vulnerability of MCF7 cells to PEMFs of 20 Hz frequency, 3 mT magnitude and exposure duration of 60 minutes per day. The cell damage accrued in response to PEMFs increased with time and gained significance after three days of consecutive daily exposure. By contrast, the PEMFs parameters determined to be most cytotoxic to breast cancer MCF-7 cells were not damaging to normal MCF-10 cells. Conclusion Based on our data it appears that PEMF-based anticancer strategies may represent a new therapeutic approach to treat breast cancer without affecting normal tissues in a manner that is non-invasive and can be potentially combined with existing anti-cancer treatments. PMID:24039828

  13. Analysis and applications of a frequency selective surface via a random distribution method

    International Nuclear Information System (INIS)

    Xie Shao-Yi; Huang Jing-Jian; Yuan Nai-Chang; Liu Li-Guo

    2014-01-01

    A novel frequency selective surface (FSS) for reducing radar cross section (RCS) is proposed in this paper. This FSS is based on the random distribution method, so it can be called random surface. In this paper, the stacked patches serving as periodic elements are employed for RCS reduction. Previous work has demonstrated the efficiency by utilizing the microstrip patches, especially for the reflectarray. First, the relevant theory of the method is described. Then a sample of a three-layer variable-sized stacked patch random surface with a dimension of 260 mm×260 mm is simulated, fabricated, and measured in order to demonstrate the validity of the proposed design. For the normal incidence, the 8-dB RCS reduction can be achieved both by the simulation and the measurement in 8 GHz–13 GHz. The oblique incidence of 30° is also investigated, in which the 7-dB RCS reduction can be obtained in a frequency range of 8 GHz–14 GHz. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  14. Affinity purification of the voltage-sensitive sodium channel from electroplax with resins selective for sialic acid

    Energy Technology Data Exchange (ETDEWEB)

    James, W.M.; Emerick, M.C.; Agnew, W.S. (Yale Univ. School of medicine, New Haven, CT (USA))

    1989-07-11

    The voltage-sensitive sodium channel present in the eel (Electrophorus electricus) has an unusually high content of sialic acid, including {alpha}-(2{yields}8)-linked polysialic acid, not found in other electroplax membrane glycopeptides. Lectins from Limax flavus (LFA) and wheat germ (WGA) proved the most effective of 11 lectin resins tried. The most selective resin was prepared from IgM antibodies against Neisseria meningitidis {alpha}-(2{yields}8)-polysialic acid which were affinity purified and coupled to Sepharose 4B. The sodium channel was found to bind to WGA, LFA, and IgM resins and was readily eluted with the appropriate soluble carbohydrates. Experiments with LFA and IgM resins demonstrated binding and unbinding rates and displacement kinetics, which suggest highly specific binding at multiple sites on the sodium channel protein. In preparative-scale purification of protein previously fractionated by anion-exchange chromatography, without stabilizing TTX, high yields were reproducibly obtained. Further, when detergent extracts were prepared from electroplax membranes fractionated by low-speed sedimentation, a single step over the IgM resin provided a 70-fold purification, yielding specific activities of 3,200 pmol of ({sup 3}H)TTX-binding sites/mg of protein and a single polypeptide of {approximately}285,000 Da on SDS-acrylamide gels. No small peptides were observed after this 5-h isolation. The authors describe a cation-dependent stabilization with millimolar levels of monovalent and micromolar levels of divalent species.

  15. Channel Selection Policy in Multi-SU and Multi-PU Cognitive Radio Networks with Energy Harvesting for Internet of Everything

    Directory of Open Access Journals (Sweden)

    Feng Hu

    2016-01-01

    Full Text Available Cognitive radio, which will become a fundamental part of the Internet of Everything (IoE, has been identified as a promising solution for the spectrum scarcity. In a multi-SU and multi-PU cognitive radio network, selecting channels is a fundamental problem due to the channel competition among secondary users (SUs and packet collision between SUs and primary users (PUs. In this paper, we adopt cooperative sensing method to avoid the packet collision between SUs and PUs and focus on how to collect the spectrum sensing data of SUs for cooperative sensing. In order to reduce the channel competition among SUs, we first consider the hybrid transmission model for single SU where a SU can opportunistically access both idle channels operating either the Overlay or the Underlay model and the busy channels by using the energy harvesting technology. Then we propose a competitive set based channel selection policy for multi-SU where all SUs competing for data transmission or energy harvesting in the same channel will form a competitive set. Extensive simulations show that the proposed cooperative sensing method and the channel selection policy outperform previous solutions in terms of false alarm, average throughput, average waiting time, and energy harvesting efficiency of SUs.

  16. The Use of Low-frequency Active Channel Signals in an Information Leakage Detection and Prevention Systems

    Directory of Open Access Journals (Sweden)

    A. V. Mamaev

    2011-06-01

    Full Text Available This article describes a solution for the protection of the temporary lifting of control over the target machine, while using information leakage detection and prevention systems. It is proposed to use a specially designed channel for alert’s signals through the computer’s power supply.

  17. Methods for estimating selected low-flow frequency statistics for unregulated streams in Kentucky

    Science.gov (United States)

    Martin, Gary R.; Arihood, Leslie D.

    2010-01-01

    This report provides estimates of, and presents methods for estimating, selected low-flow frequency statistics for unregulated streams in Kentucky including the 30-day mean low flows for recurrence intervals of 2 and 5 years (30Q2 and 30Q5) and the 7-day mean low flows for recurrence intervals of 5, 10, and 20 years (7Q2, 7Q10, and 7Q20). Estimates of these statistics are provided for 121 U.S. Geological Survey streamflow-gaging stations with data through the 2006 climate year, which is the 12-month period ending March 31 of each year. Data were screened to identify the periods of homogeneous, unregulated flows for use in the analyses. Logistic-regression equations are presented for estimating the annual probability of the selected low-flow frequency statistics being equal to zero. Weighted-least-squares regression equations were developed for estimating the magnitude of the nonzero 30Q2, 30Q5, 7Q2, 7Q10, and 7Q20 low flows. Three low-flow regions were defined for estimating the 7-day low-flow frequency statistics. The explicit explanatory variables in the regression equations include total drainage area and the mapped streamflow-variability index measured from a revised statewide coverage of this characteristic. The percentage of the station low-flow statistics correctly classified as zero or nonzero by use of the logistic-regression equations ranged from 87.5 to 93.8 percent. The average standard errors of prediction of the weighted-least-squares regression equations ranged from 108 to 226 percent. The 30Q2 regression equations have the smallest standard errors of prediction, and the 7Q20 regression equations have the largest standard errors of prediction. The regression equations are applicable only to stream sites with low flows unaffected by regulation from reservoirs and local diversions of flow and to drainage basins in specified ranges of basin characteristics. Caution is advised when applying the equations for basins with characteristics near the

  18. Selecting participants for listening tests of multi-channel reproduced sound

    DEFF Research Database (Denmark)

    Wickelmaier, Florian Maria; Choisel, Sylvain

    2005-01-01

    A selection procedure was devised in order to select listeners for experiments in which their main task will be to judge multichannel reproduced sound. Ninety-one participants filled in a web-based questionnaire. Seventy-eight of them took part in an assessment of their hearing thresholds......, their spatial hearing, and their verbal production abilities. The listeners displayed large individual differences in their performance. Forty subjects were selected based on the test results. The self-assessed listening habits and experience in the web-questionnaire could not predict the results...... of the selection procedure. Further, the hearing thresholds did not correlate with the spatial-hearing test. This leads to the conclusion that task-specific performance tests might be the preferable means of selecting a listening panel....

  19. Non-selective cation channels and oxidative stress- induced cell swelling

    Directory of Open Access Journals (Sweden)

    FELIPE SIMON

    2002-01-01

    Full Text Available Necrosis is considered as a non-specific form of cell death that induces tissue inflammation and is preceded by cell swelling. This increase in cell volume has been ascribed mainly to defective outward pumping of Na+ caused by metabolic depletion and/or to increased Na+ influx via membrane transporters. A specific mechanism of swelling and necrosis driven by the influx of Na+ through nonselective cation channels has been recently proposed (Barros et al., 2001a. We have characterized further the properties of the nonselective cation channel (NSCC in HTC cells. The NSCC shows a conductance of ~18 pS, is equally permeable to Na+ and K+, impermeant to Ca2+, requires high intracellular Ca2+ as well as low intracellular ATP for activation and is inhibited by flufenamic acid. Hydrogen peroxide induced a significant increase in cell volume that was dependent on external Na+. We propose that the NSCC, which is ubiquitous though largely inactive in healthy cells, becomes activated under severe oxidative stress. The ensuing Na+ influx initiates via positive feedback a series of metabolic and electrolytic disturbances, resulting in cell death by necrosis

  20. A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids

    Science.gov (United States)

    Hu, Zhaonong; Du, Yuzhe; Nomura, Yoshiko; Dong, Ke

    2010-01-01

    Voltage-gated sodium channels are the primary target of pyrethroid insecticides. Numerous point mutations in sodium channel genes have been identified in pyrethroid-resistant insect species, and many have been confirmed to reduce or abolish sensitivity of channels expressed in Xenopus oocytes to pyrethroids. Recently, several novel mutations were reported in sodium channel genes of pyrethroid-resistant Aedes mosquito populations. One of the mutations is a phenylalanine (F) to cysteine (C) change in segment 6 of domain III (IIIS6) of the Aedes mosquito sodium channel. Curiously, a previous study showed that alanine substitution of this F did not alter the action of deltamethrin, a type II pyrethroid, on a cockroach sodium channel. In this study, we changed this F to C in a pyrethroid-sensitive cockroach sodium channel and examined mutant channel sensitivity to permethrin as well as five other type I or type II pyrethroids in Xenopus oocytes. Interestingly, the F to C mutation drastically reduced channel sensitivity to three type I pyrethroids, permethrin, NRDC 157 (a deltamethrin analogue lacking the α-cyano group) and bioresemthrin, but not to three type II pyrethroids, cypermethrin, deltamethrin and cyhalothrin. These results confirm the involvement of the F to C mutation in permethrin resistance, and raise the possibility that rotation of type I and type II pyrethroids might be considered in the control of insect pest populations where this particular mutation is present. PMID:20869441

  1. Low frequency noise assessment in n- and p-channel sub-10 nm triple-gate FinFETs: Part I: Theory and methodology

    Science.gov (United States)

    Boudier, D.; Cretu, B.; Simoen, E.; Carin, R.; Veloso, A.; Collaert, N.; Thean, A.

    2017-02-01

    The transfer characteristic at room temperature of FinFETs processed for sub-10 nm technologies could always be explained by solving Poisson equation throughout the channel - dielectric interface. Various methods for the MOSFET parameters estimation are proposed in the literature. In this paper, the electrical parameters extraction technique based on the Y-function methodology is reminded. Low frequency noise is presented considering three major noise sources: 1/f noise associated to carrier trapping-detrapping in the gate oxide, channel carrier mobility fluctuations and generation-recombination noise related to traps located in the depletion zone of the device. Theory and methodology in order to identify the 1/f noise mechanism and to have information of the process induced traps in the silicon film using the noise spectroscopy technique are revisited.

  2. Demographic model selection using random forests and the site frequency spectrum.

    Science.gov (United States)

    Smith, Megan L; Ruffley, Megan; Espíndola, Anahí; Tank, David C; Sullivan, Jack; Carstens, Bryan C

    2017-09-01

    Phylogeographic data sets have grown from tens to thousands of loci in recent years, but extant statistical methods do not take full advantage of these large data sets. For example, approximate Bayesian computation (ABC) is a commonly used method for the explicit comparison of alternate demographic histories, but it is limited by the "curse of dimensionality" and issues related to the simulation and summarization of data when applied to next-generation sequencing (NGS) data sets. We implement here several improvements to overcome these difficulties. We use a Random Forest (RF) classifier for model selection to circumvent the curse of dimensionality and apply a binned representation of the multidimensional site frequency spectrum (mSFS) to address issues related to the simulation and summarization of large SNP data sets. We evaluate the performance of these improvements using simulation and find low overall error rates (~7%). We then apply the approach to data from Haplotrema vancouverense, a land snail endemic to the Pacific Northwest of North America. Fifteen demographic models were compared, and our results support a model of recent dispersal from coastal to inland rainforests. Our results demonstrate that binning is an effective strategy for the construction of a mSFS and imply that the statistical power of RF when applied to demographic model selection is at least comparable to traditional ABC algorithms. Importantly, by combining these strategies, large sets of models with differing numbers of populations can be evaluated. © 2017 John Wiley & Sons Ltd.

  3. FEA modeling of CMUT with membrane stand-off structures to enable selectable frequency-mode operation.

    Science.gov (United States)

    Eames, Matthew D C; Reck, Theodore J; Kilroy, Joseph P; Hossack, John A

    2011-12-01

    A selectable, dual-frequency, capacitive micro- machined ultrasonic transducer (CMUT) designed for both high-frequency imaging and low-frequency therapeutic effect is presented. A validated finite element analysis (FEA) CMUT model was used to examine the performance of the proposed dual-frequency transducer. CMUT device simulations were used to design a hybrid device incorporating stand-off structures that divide a large, low-frequency membrane into smaller, high-frequency sub-membranes when the membrane is partially collapsed so that the stand-offs contact the substrate. In low-frequency operation, simulations indicated that the peak negative pressure achieved by the hybrid device, when biased by 30.0 VDC and excited by a 2-MHz signal with 30.0 V amplitude, exceeded 190 kPa, which is sufficient for microbubble rupture. Low-frequency mode bandwidth was 93% at a center frequency of 2.1 MHz. In the high-frequency mode of operation, the device was excited by 175 Vdc and 87.5 Vac, which generated a peak negative pressure of 247 kPa. Device center frequency was 44.1 MHz with a - 6-dB fractional bandwidth of 42%.

  4. Biomarker selection for determining bone biocompatibility of pure magnesium processed by equal channel angular pressing (ECAP) using immunohistochemistry

    Science.gov (United States)

    Handayani, Lisa; Sulistyani, Lilies Dwi; Supriadi, Sugeng; Priosoeryanto, Bambang Pontjo; Latief, Benny Syariefsyah

    2018-02-01

    Since grain refinement is proved to be favorable to improve mechanical properties and corrosion resistance, a new conceptual metal forming process, equal channel angular pressing (ECAP), has been carried out on magnesium, a very promising biodegradable material in the field of oral and maxillofacial surgery. The popularity of immunohisto-chemistry (IHC) has been rising following the discovery of biomarker. In the meantime, more antibodies being produced for research have been continuously rising and becoming more varied. This review provides a conceptual framework to understand the roles of IHC on determination of bone biocompatibility to ECAP magnesium by selecting biomarker and point needed to either select or make an antibody to the target. From the review, it has been concluded that the most suitable biomarkers for biocompatibility test of bone implanted with ECAP magnesium are collagen-1, osteocalcin, smooth muscle actin, and CD68.

  5. Space-time trellis coding with transmit laser selection for FSO links over strong atmospheric turbulence channels.

    Science.gov (United States)

    García-Zambrana, Antonio; Castillo-Vázquez, Carmen; Castillo-Vázquez, Beatriz

    2010-03-15

    Atmospheric turbulence produces fluctuations in the irradiance of the transmitted optical beam, which is known as atmospheric scintillation, severely degrading the link performance. In this paper, a scheme combining transmit laser selection (TLS) and space-time trellis code (STTC) for multiple-input-single-output (MISO) free-space optical (FSO) communication systems with intensity modulation and direct detection (IM/DD) over strong atmospheric turbulence channels is analyzed. Assuming channel state information at the transmitter and receiver, we propose the transmit diversity technique based on the selection of two out of the available L lasers corresponding to the optical paths with greater values of scintillation to transmit the baseline STTCs designed for two transmit antennas. Based on a pairwise error probability (PEP) analysis, results in terms of bit error rate are presented when the scintillation follows negative exponential and K distributions, which cover a wide range of strong atmospheric turbulence conditions. Obtained results show a diversity order of 2L-1 when L transmit lasers are available and a simple two-state STTC with rate 1 bit/(s .Hz) is used. Simulation results are further demonstrated to confirm the analytical results.

  6. OH radical initiated oxidation of 1,3-butadiene: isomeric selective study of the dominant addition channel.

    Science.gov (United States)

    Ghosh, Buddhadeb; Bugarin, Alejandro; Connell, Brian T; North, Simon W

    2010-04-29

    We report the first isomeric selective kinetic study of the dominant isomeric pathway in the OH initiated oxidation of 1,3-butadiene in the presence of O(2) and NO using the laser photolysis-laser induced fluorescence (LP-LIF) technique. The photodissociation of the precursor 2-iodo-but-3-en-1-ol results exclusively in the dominant OH-butadiene addition product, permitting important insight into the OH initiated oxidation mechanism. On the basis of analysis of the time dependent OH/OD signals, we have determined a rate constant for O2 addition to the hydroxyalkyl radical of 7.0(-3.0)(+7.0) x 10(-13) cm(3) s(-1), and we find a value of 1.5(-0.6)(+1.0) x 10(-11) cm(3) s(-1) for the overall reaction rate constant of the hydroxy peroxy radical with NO. We also report the first clear experimental evidence of the (E) form of the delta-hydroxyalkoxy channel through isotopic labeling experiments and provide an upper bound of 13 +/- 5% to its branching ratio. This species provides a mechanistic pathway for the formation of 4-hydroxy-2-butenal, which has been identified as a first generation end product. This isomeric selective kinetic study, together with a previous study on the minor channel of the 1,3-butadiene oxidation, yields a comprehensive picture of butadiene oxidation under high NOx conditions relevant to most regions in the continental US.

  7. All-metal frequency-selective absorber/emitter for laser stealth and infrared stealth.

    Science.gov (United States)

    Zhao, Lei; Liu, Han; He, Zhihong; Dong, Shikui

    2018-03-10

    In this paper, an all-metal nanostructure is designed with a large frequency ratio (∼6) and a large bandwidth ratio (∼32), and consists of period slit-box cavities and nanodisk clusters. It is a nearly perfect absorber at 1.064 μm to achieve laser stealth, a frequency-selective emitter with low emissivity in wavelength ranges 3-5 and 8-14 μm to achieve infrared stealth, and also an emitter with near unity emissivity at 2.709 μm and 6.107 μm to compensate for the decrease of radiation heat transfer owing to the low emissivity. The absorption/emission peaks are all the Lorentzian shape, and the bandwidths, defined as full width at half-maximum, are 35, 408, and 1124 nm at 1.064, 2.709, and 6.107 μm, respectively. The electric and magnetic field distribution shows that the slit behaves like a capacitor, the box behaves like an inductance, and the nanodisk clusters can excite electric dipole resonance. Considering the solar irradiation, the nanostructure maintains middle-wavelength infrared signal reduction rates greater than 80% from 450 to 1000 K, and long-wavelength infrared signal reduction rates greater than 90% from room temperature to 1000 K. The laser and infrared stealth performances of our nanostructure at 473 K are also studied with different incident angles and polarization angles.

  8. Frequency Selective Non-Linear Blending to Improve Image Quality in Liver CT.

    Science.gov (United States)

    Bongers, M N; Bier, G; Kloth, C; Schabel, C; Fritz, J; Nikolaou, K; Horger, M

    2016-12-01

    Purpose: To evaluate the effects of a new frequency selective non-linear blending (NLB) algorithm on the contrast resolution of liver CT with low intravascular concentration of iodine contrast. Materials and Methods: Our local ethics committee approved this retrospective study. The informed consent requirement was waived. CT exams of 25 patients (60 % female, mean age: 65 ± 16 years of age) with late phase CT scans of the liver were included as a model for poor intrahepatic vascular contrast enhancement. Optimal post-processing settings to enhance the contrast of hepatic vessels were determined. Outcome variables included signal-to-noise (SNR) and contrast-to-noise ratios (CNR) of hepatic vessels and SNR of liver parenchyma of standard and post-processed images. Image quality was quantified by two independent readers using Likert scales. Results: The post-processing settings for the visualization of hepatic vasculature were optimal at a center of 115HU, delta of 25HU, and slope of 5. Image noise was statistically indifferent between standard and post-processed images. The CNR between the hepatic vasculature (HV) and liver parenchyma could be significantly increased for liver veins (CNR Standard 1.62 ± 1.10, CNR NLB 3.6 ± 2.94, p = 0.0002) and portal veins (CNR Standard 1.31 ± 0.85, CNR NLB 2.42 ± 3.03, p = 0.046). The SNR of liver parenchyma was significantly higher on post-processed images (SNR NLB 11.26 ± 3.16, SNR Standard 8.85 ± 2.27, p = 0.008). The overall image quality and depiction of HV were significantly higher on post-processed images (NLB DHV : 4 [3 - 4.75], S tandardDHV : 2 [1.3 - 2.5], p = algorithm increases the contrast resolution of liver CT and can improve the visibility of the hepatic vasculature in the setting of a low contrast ratio between vessels and the parenchyma. Key Points: • Using the new frequency selective non-linear blending algorithm is feasible in contrast

  9. Frequency selective non-linear blending to improve image quality in liver CT

    International Nuclear Information System (INIS)

    Bongers, M.N.; Bier, G.; Kloth, C.; Schabel, C.; Nikolaou, K.; Horger, M.; Fritz, J.

    2016-01-01

    To evaluate the effects of a new frequency selective non-linear blending (NLB) algorithm on the contrast resolution of liver CT with low intravascular concentration of iodine contrast. Our local ethics committee approved this retrospective study. The informed consent requirement was waived. CT exams of 25 patients (60% female, mean age: 65±16 years of age) with late phase CT scans of the liver were included as a model for poor intrahepatic vascular contrast enhancement. Optimal post-processing settings to enhance the contrast of hepatic vessels were determined. Outcome variables included signal-to-noise (SNR) and contrast-to-noise ratios (CNR) of hepatic vessels and SNR of liver parenchyma of standard and post-processed images. Image quality was quantified by two independent readers using Likert scales. The post-processing settings for the visualization of hepatic vasculature were optimal at a center of 115HU, delta of 25HU, and slope of 5. Image noise was statistically indifferent between standard and post-processed images. The CNR between the hepatic vasculature (HV) and liver parenchyma could be significantly increased for liver veins (CNR Standard 1.62±1.10, CNR NLB 3.6±2.94, p=0.0002) and portal veins (CNR Standard 1.31±0.85, CNR NLB 2.42±3.03, p=0.046). The SNR of liver parenchyma was significantly higher on post-processed images (SNR NLB 11.26±3.16, SNR Standard 8.85± 2.27, p=0.008). The overall image quality and depiction of HV were significantly higher on post-processed images (NLB DHV : 4 [3-4.75], S tandardDHV : 2 [1.3-2.5], p=<0.0001; NLBIQ : 4 [4-4], StandardIQ : 2 [2-3], p=<0.0001). The use of a frequency selective non-linear blending algorithm increases the contrast resolution of liver CT and can improve the visibility of the hepatic vasculature in the setting of a low contrast ratio between vessels and the parenchyma.

  10. Frequency selective non-linear blending to improve image quality in liver CT

    Energy Technology Data Exchange (ETDEWEB)

    Bongers, M.N.; Bier, G.; Kloth, C.; Schabel, C.; Nikolaou, K.; Horger, M. [University Hospital of Tuebingen (Germany). Dept. of Diagnostic and Interventional Radiology; Fritz, J. [Johns Hopkins University School of Medicine, Baltimore, MD (United States). Russell H. Morgan Dept. of Radiology and Radiological Science

    2016-12-15

    To evaluate the effects of a new frequency selective non-linear blending (NLB) algorithm on the contrast resolution of liver CT with low intravascular concentration of iodine contrast. Our local ethics committee approved this retrospective study. The informed consent requirement was waived. CT exams of 25 patients (60% female, mean age: 65±16 years of age) with late phase CT scans of the liver were included as a model for poor intrahepatic vascular contrast enhancement. Optimal post-processing settings to enhance the contrast of hepatic vessels were determined. Outcome variables included signal-to-noise (SNR) and contrast-to-noise ratios (CNR) of hepatic vessels and SNR of liver parenchyma of standard and post-processed images. Image quality was quantified by two independent readers using Likert scales. The post-processing settings for the visualization of hepatic vasculature were optimal at a center of 115HU, delta of 25HU, and slope of 5. Image noise was statistically indifferent between standard and post-processed images. The CNR between the hepatic vasculature (HV) and liver parenchyma could be significantly increased for liver veins (CNR{sub Standard} 1.62±1.10, CNR{sub NLB} 3.6±2.94, p=0.0002) and portal veins (CNR{sub Standard} 1.31±0.85, CNR{sub NLB} 2.42±3.03, p=0.046). The SNR of liver parenchyma was significantly higher on post-processed images (SNR{sub NLB} 11.26±3.16, SNR{sub Standard} 8.85± 2.27, p=0.008). The overall image quality and depiction of HV were significantly higher on post-processed images (NLB{sub DHV}: 4 [3-4.75], S{sub tandardDHV}: 2 [1.3-2.5], p=<0.0001; {sub NLBIQ}: 4 [4-4], {sub StandardIQ}: 2 [2-3], p=<0.0001). The use of a frequency selective non-linear blending algorithm increases the contrast resolution of liver CT and can improve the visibility of the hepatic vasculature in the setting of a low contrast ratio between vessels and the parenchyma.

  11. Performance analysis of selective cooperation in underlay cognitive networks over Rayleigh channels

    KAUST Repository

    Hussain, Syed Imtiaz

    2011-06-01

    Underlay cognitive networks should follow strict interference thresholds to operate in parallel with primary networks. This constraint limits their transmission power and eventually the area of coverage. Therefore, it is very likely that the underlay networks will make use of relays to transmit signals to the distant secondary users. In this paper, we propose a secondary relay selection scheme which maximizes the end-to-end signal to noise ratio (SNR) for the secondary link while keeping the interference levels to the primary network below a certain threshold. We derive closed form expressions for the probability density function (PDF) of the SNR at the secondary destination, average bit error probability and outage probability. Analytical results are verified through simulations which also give insight about the benefits and tradeoffs of the selective cooperation in underlay cognitive networks. It is shown that, in contrast to non-cognitive selective cooperation, this scheme performs better in low SNR region for cognitive networks. © 2011 IEEE.

  12. An Improved Endmember Selection Method Based on Vector Length for MODIS Reflectance Channels

    Directory of Open Access Journals (Sweden)

    Yuanliu Xu

    2015-05-01

    Full Text Available Endmember selection is the basis for sub-pixel land cover classifications using multiple endmember spectral mixture analysis (MESMA that adopts variant endmember matrices for each pixel to mitigate errors caused by endmember variability in SMA. A spectral library covering a large number of endmembers can account for endmember variability, but it also lowers the computational efficiency. Therefore, an efficient endmember selection scheme to optimize the library is crucial to implement MESMA. In this study, we present an endmember selection method based on vector length. The spectra of a land cover class were divided into subsets using vector length intervals of the spectra, and the representative endmembers were derived from these subsets. Compared with the available endmember average RMSE (EAR method, our approach improved the computational efficiency in endmember selection. The method accuracy was further evaluated using spectral libraries derived from the ground reference polygon and Moderate Resolution Imaging Spectroradiometer (MODIS imagery respectively. Results using the different spectral libraries indicated that MESMA combined with the new approach performed slightly better than EAR method, with Kappa coefficient improved from 0.75 to 0.78. A MODIS image was used to test the mapping fraction, and the representative spectra based on vector length successfully modeled more than 90% spectra of the MODIS pixels by 2-endmember models.

  13. Comparative Study on the Selection Criteria for Fitting Flood Frequency Distribution Models with Emphasis on Upper-Tail Behavior

    Directory of Open Access Journals (Sweden)

    Xiaohong Chen

    2017-05-01

    Full Text Available The upper tail of a flood frequency distribution is always specifically concerned with flood control. However, different model selection criteria often give different optimal distributions when the focus is on the upper tail of distribution. With emphasis on the upper-tail behavior, five distribution selection criteria including two hypothesis tests and three information-based criteria are evaluated in selecting the best fitted distribution from eight widely used distributions by using datasets from Thames River, Wabash River, Beijiang River and Huai River. The performance of the five selection criteria is verified by using a composite criterion with focus on upper tail events. This paper demonstrated an approach for optimally selecting suitable flood frequency distributions. Results illustrate that (1 there are different selections of frequency distributions in the four rivers by using hypothesis tests and information-based criteria approaches. Hypothesis tests are more likely to choose complex, parametric models, and information-based criteria prefer to choose simple, effective models. Different selection criteria have no particular tendency toward the tail of the distribution; (2 The information-based criteria perform better than hypothesis tests in most cases when the focus is on the goodness of predictions of the extreme upper tail events. The distributions selected by information-based criteria are more likely to be close to true values than the distributions selected by hypothesis test methods in the upper tail of the frequency curve; (3 The proposed composite criterion not only can select the optimal distribution, but also can evaluate the error of estimated value, which often plays an important role in the risk assessment and engineering design. In order to decide on a particular distribution to fit the high flow, it would be better to use the composite criterion.

  14. Controlling the Short-Range Propagation Environment Using Active Frequency Selective Surfaces

    Directory of Open Access Journals (Sweden)

    L. Subrt

    2010-12-01

    Full Text Available This paper deals with a new approach to the control of the propagation environment in indoor scenarios using intelligent walls. The intelligent wall is a conventional wall situated inside a building, but equipped with an active frequency selective surface and sensors. The intelligent wall can be designed as a self-configuring and self-optimizing autonomous part of a collaborative infrastructure working within a high-capacity mobile radio system. The paper shows how such surfaces can be used to adjust the electromagnetic characteristics of the wall in response to changes in traffic demand, monitored using a network of sensors, thereby controlling the propagation environment inside the building. Some of the potential problems (mainly controlling coverage and interference relating to an increased usage of wireless systems both inside and outside buildings are discussed and possible solutions using intelligent walls with the active FSS are suggested. The positive influence of intelligent walls on system performance is shown and results obtained from the simulations are shown and discussed.

  15. [The effect of high-frequency current and ultrasonic wave on selected indicators of body weight].

    Science.gov (United States)

    Kiełczewska, Magdalena; Szymczyk, Jerzy; Leszczyńsk, Ryszard; Błaszczyk, Jan

    2015-03-01

    Effective change the appearance of the body through available both invasive and non-invasive methods such as treatment has been documented in numerous clinical trials. Liposuction and lipoplasty are currently the most widely used methods of reducing fat deposits. Technological advances made has become increasingly popular use of invasive procedures using energy fields and high-frequency ultrasonic wave. It is now one of the most effective and safe methods of treatment, based on the principle of mechanical and thermal stimulation of the physiological processes leading to the reduction of locally accumulated fat. The aim of the study was to evaluate the behavior of selected parameters of body weight in patients undergoing fat reduction BTL Exilis device. IThe study included a 50-group of women who are patients of the Specialist Outpatient Clinic Al-Med in Kolobrzeg. Taken twice the measurement of body weight, waist circumference and thickness measurement of skinfolds before the first treatment, and after a series of treatments. Treatment consisted of 4 sessions while maintaining the 10-day interval between treatments. In the study a statistically significant reduction in the studied parameters such as actual body weight, waist circumference, fat mass and thickness of the skinfolds were showed. The effect of treatment with the energy field of highfrequency ultrasonic wave in a reduction in the size of fat body mass and improving the contour shape. Willingness to continue participation examined in this type of surgery proves positive reception of therapy and its effectiveness. © 2015 MEDPRESS.

  16. Channel capacity of TDD-OFDM-MIMO for multiple access points in a wireless single-frequency-network

    DEFF Research Database (Denmark)

    Takatori, Y.; Fitzek, Frank; Tsunekawa, K.

    2005-01-01

    The multiple-input-multiple-output (MIMO) technique is the most attractive candidate to improve the spectrum efficiency in the next generation wireless communication systems. However, the efficiency of MIMO techniques reduces in the line of sight (LOS) environments. In this paper, we propose a new...... LOS and non line of sight (NLOS) environments. The channel capacity of the proposed method is derived for the direct path environments and it confirms the effectiveness of the proposed scheme in the LOS scenario. Moreover, solid computer simulation results confirm the effectiveness of the proposed...

  17. Method and Apparatus of Multiplexing and Acquiring Data from Multiple Optical Fibers Using a Single Data Channel of an Optical Frequency-Domain Reflectometry (OFDR) System

    Science.gov (United States)

    Parker, Jr., Allen R (Inventor); Chan, Hon Man (Inventor); Piazza, Anthony (Nino) (Inventor); Richards, William Lance (Inventor)

    2014-01-01

    A method and system for multiplexing a network of parallel fiber Bragg grating (FBG) sensor-fibers to a single acquisition channel of a closed Michelson interferometer system via a fiber splitter by distinguishing each branch of fiber sensors in the spatial domain. On each branch of the splitter, the fibers have a specific pre-determined length, effectively separating each branch of fiber sensors spatially. In the spatial domain the fiber branches are seen as part of one acquisition channel on the interrogation system. However, the FBG-reference arm beat frequency information for each fiber is retained. Since the beat frequency is generated between the reference arm, the effective fiber length of each successive branch includes the entire length of the preceding branch. The multiple branches are seen as one fiber having three segments where the segments can be resolved. This greatly simplifies optical, electronic and computational complexity, and is especially suited for use in multiplexed or branched OFS networks for SHM of large and/or distributed structures which need a lot of measurement points.

  18. High and low fat food selection with reported frequency intolerance following Roux-en-Y gastric bypass.

    Science.gov (United States)

    Thomas, Jack R; Marcus, Emily

    2008-03-01

    This research compared both food selection and food intolerance frequency of High-fat grouped foods versus Low-fat grouped foods in Roux-en-Y bariatric clients during their dietary adaptation phase (DAP). Thirty-eight bariatric surgery patients in their dietary transition phase (3 months-2.5 years) filled out a 236-food item questionnaire. From the larger set of primary data, 24 high-fat (30% or greater fat) and 22 low/lower-fat food items were itemized by selection frequency and food intolerance frequency for comparison. High-fat food selection was 38.3% against low fat at 50.4% (p = .0002). For comparison, the complete questionnaire's 236-item food selection percentage was 41%. Frequency of "Never" experiencing food intolerance was similar between both groups with a combined mean of 1.92%. "Seldom to Sometimes" intolerance in low-fat foods was 13.3%, and 24.9% in high fat (p = .002). Finally, "Often to Always" experiencing food intolerance in the Low-fat food group was 85.5% versus 72.2% for the High-fat group (p = .002). Roux-en-Y bariatric patients in the DAP demonstrated typical "dieting behavior" by selecting low-fat foods at a greater frequency than high-fat foods. Although selected more, these low-fat foods also showed significantly worse intolerance frequencies. Thus, current dietary/nutrition professional recommendations to avoid high-fat foods during this postsurgery transition time are problematic. Future bariatric studies are needed to further explore this and other commonly practiced "dieting behaviors" in bariatric patients.

  19. The partner selection process of alliances in the manufacturer-distributor marketing channel: a case approach

    OpenAIRE

    Laffan, Joanne

    1996-01-01

    The past decade has seen an upsurge in the number of strategic alliances entered into by companies in the international business arena. Such alliances may offer opportunities to Irish companies who strive to increase their sales and expand into overseas markets. However, many of these alliances have ended in failure, often due to poor partner selection and management of the alliance. Despite the increase in research examining ways in which companies can improve their ability to ‘get it ri...

  20. Food advertising on Australian television: Frequency, duration and monthly pattern of advertising from a commercial network (four channels) for the entire 2016.

    Science.gov (United States)

    Smithers, Lisa G; Haag, Dandara G; Agnew, Benjamin; Lynch, John; Sorell, Matthew

    2018-04-16

    To estimate the frequency, duration and monthly pattern of discretionary food advertising on Australian free-to-air television. We logged 30 000 h of television collected in Adelaide during 2016 from one network that has four channels. The Australian Guide to Healthy Eating was used to identify discretionary foods. Data were examined according to all times, to children's peak viewing times (PVTs) and to when C-(children's) rated programmes may be broadcast. Of the >800 000 advertisements logged during 2016, 11% were for foods (n = 97 837). The most frequently advertised products were: snack foods (e.g. crisps), crumbed/battered meats, fast foods/take away meals and sweetened beverages. The frequency and duration of discretionary food advertising was 1.7 times/h and 0.5 min/h respectively at all times. During children's PVTs, the frequency and duration of discretionary food advertising was 2.3 times/h and 0.7 min/h, respectively. When C-rated programmes can be broadcast, the frequency and duration of discretionary food advertising was 1.8 times/h and 0.6 min/h, respectively. Across the year, discretionary foods ranged between 41% (August) and 71% (January) of all food advertising. Discretionary foods dominate food advertising. On average, discretionary food advertising was higher during PVTs for children and during the summer school holidays (January). © 2018 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

  1. Photonic Crystal Fiber-Based Surface Plasmon Resonance Sensor with Selective Analyte Channels and Graphene-Silver Deposited Core

    Directory of Open Access Journals (Sweden)

    Ahmmed A. Rifat

    2015-05-01

    Full Text Available We propose a surface plasmon resonance (SPR sensor based on photonic crystal fiber (PCF with selectively filled analyte channels. Silver is used as the plasmonic material to accurately detect the analytes and is coated with a thin graphene layer to prevent oxidation. The liquid-filled cores are placed near to the metallic channel for easy excitation of free electrons to produce surface plasmon waves (SPWs. Surface plasmons along the metal surface are excited with a leaky Gaussian-like core guided mode. Numerical investigations of the fiber’s properties and sensing performance are performed using the finite element method (FEM. The proposed sensor shows maximum amplitude sensitivity of 418 Refractive Index Units (RIU−1 with resolution as high as 2.4 × 10−5 RIU. Using the wavelength interrogation method, a maximum refractive index (RI sensitivity of 3000 nm/RIU in the sensing range of 1.46–1.49 is achieved. The proposed sensor is suitable for detecting various high RI chemicals, biochemical and organic chemical analytes. Additionally, the effects of fiber structural parameters on the properties of plasmonic excitation are investigated and optimized for sensing performance as well as reducing the sensor’s footprint.

  2. Photonic crystal fiber-based surface plasmon resonance sensor with selective analyte channels and graphene-silver deposited core.

    Science.gov (United States)

    Rifat, Ahmmed A; Mahdiraji, G Amouzad; Chow, Desmond M; Shee, Yu Gang; Ahmed, Rajib; Adikan, Faisal Rafiq Mahamd

    2015-05-19

    We propose a surface plasmon resonance (SPR) sensor based on photonic crystal fiber (PCF) with selectively filled analyte channels. Silver is used as the plasmonic material to accurately detect the analytes and is coated with a thin graphene layer to prevent oxidation. The liquid-filled cores are placed near to the metallic channel for easy excitation of free electrons to produce surface plasmon waves (SPWs). Surface plasmons along the metal surface are excited with a leaky Gaussian-like core guided mode. Numerical investigations of the fiber's properties and sensing performance are performed using the finite element method (FEM). The proposed sensor shows maximum amplitude sensitivity of 418 Refractive Index Units (RIU-1) with resolution as high as 2.4 × 10(-5) RIU. Using the wavelength interrogation method, a maximum refractive index (RI) sensitivity of 3000 nm/RIU in the sensing range of 1.46-1.49 is achieved. The proposed sensor is suitable for detecting various high RI chemicals, biochemical and organic chemical analytes. Additionally, the effects of fiber structural parameters on the properties of plasmonic excitation are investigated and optimized for sensing performance as well as reducing the sensor's footprint.

  3. End-to-End Joint Antenna Selection Strategy and Distributed Compress and Forward Strategy for Relay Channels

    Directory of Open Access Journals (Sweden)

    Rahul Vaze

    2009-01-01

    Full Text Available Multihop relay channels use multiple relay stages, each with multiple relay nodes, to facilitate communication between a source and destination. Previously, distributed space-time codes were proposed to maximize the achievable diversity-multiplexing tradeoff; however, they fail to achieve all the points of the optimal diversity-multiplexing tradeoff. In the presence of a low-rate feedback link from the destination to each relay stage and the source, this paper proposes an end-to-end antenna selection (EEAS strategy as an alternative to distributed space-time codes. The EEAS strategy uses a subset of antennas of each relay stage for transmission of the source signal to the destination with amplifying and forwarding at each relay stage. The subsets are chosen such that they maximize the end-to-end mutual information at the destination. The EEAS strategy achieves the corner points of the optimal diversity-multiplexing tradeoff (corresponding to maximum diversity gain and maximum multiplexing gain and achieves better diversity gain at intermediate values of multiplexing gain, versus the best-known distributed space-time coding strategies. A distributed compress and forward (CF strategy is also proposed to achieve all points of the optimal diversity-multiplexing tradeoff for a two-hop relay channel with multiple relay nodes.

  4. Development of selective blockers for Ca2+-activated Cl- channel using Xenopus laevis oocytes with an improved drug screening strategy

    Directory of Open Access Journals (Sweden)

    Oh Soo-Jin

    2008-10-01

    Full Text Available Abstract Background Ca2+-activated Cl- channels (CaCCs participate in many important physiological processes. However, the lack of effective and selective blockers has hindered the study of these channels, mostly due to the lack of good assay system. Here, we have developed a reliable drug screening method for better blockers of CaCCs, using the endogeneous CaCCs in Xenopus laevis oocytes and two-electrode voltage-clamp (TEVC technique. Results Oocytes were prepared with a treatment of Ca2+ ionophore, which was followed by a treatment of thapsigargin which depletes Ca2+ stores to eliminate any contribution of Ca2+ release. TEVC was performed with micropipette containing chelerythrine to prevent PKC dependent run-up or run-down. Under these conditions, Ca2+-activated Cl- currents induced by bath application of Ca2+ to oocytes showed stable peak amplitude when repetitively activated, allowing us to test several concentrations of a test compound from one oocyte. Inhibitory activities of commercially available blockers and synthesized anthranilic acid derivatives were tested using this method. As a result, newly synthesized N-(4-trifluoromethylphenylanthranilic acid with trifluoromethyl group (-CF3 at para position on the benzene ring showed the lowest IC50. Conclusion Our results provide an optimal drug screening strategy suitable for high throughput screening, and propose N-(4-trifluoromethylphenylanthranilic acid as an improved CaCC blocker.

  5. Novel selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2

    Science.gov (United States)

    Kasumu, AW; Hougaard, C; Rode, F; Jacobsen, TA; Sabatier, JM; Eriksen, BL; Strøbæk, D; Liang, X; Egorova, P; Vorontsova, D; Christophersen, P; Rønn, LCB; Bezprozvanny, I

    2012-01-01

    Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disorder caused by a polyglutamine expansion within the Ataxin-2 (Atxn2) protein. Purkinje cells (PC) of the cerebellum fire irregularly and eventually die in SCA2. We show here that the type 2 small conductance calcium-activated potassium channel (SK2) play a key role in control of normal PC activity. Using cerebellar slices from transgenic SCA2 mice we demonstrate that SK channel modulators restore regular pacemaker activity of SCA2 PCs. Furthermore, we also show that oral delivery of a novel selective positive modulator of SK2/3 channels (NS13001) alleviates behavioural and neuropathological phenotypes of aging SCA2 transgenic mice. We conclude that SK2 channels constitute a novel target for SCA2 treatment and that the developed selective SK2/3 modulator NS13001 holds promise as a potential therapeutic agent for treatment of SCA2 and possibly other cerebellar ataxias. PMID:23102227

  6. On the performance of joint iterative detection and decoding in coherent optical channels with laser frequency fluctuations

    Science.gov (United States)

    Castrillón, Mario A.; Morero, Damián A.; Agazzi, Oscar E.; Hueda, Mario R.

    2015-08-01

    The joint iterative detection and decoding (JIDD) technique has been proposed by Barbieri et al. (2007) with the objective of compensating the time-varying phase noise and constant frequency offset experienced in satellite communication systems. The application of JIDD to optical coherent receivers in the presence of laser frequency fluctuations has not been reported in prior literature. Laser frequency fluctuations are caused by mechanical vibrations, power supply noise, and other mechanisms. They significantly degrade the performance of the carrier phase estimator in high-speed intradyne coherent optical receivers. This work investigates the performance of the JIDD algorithm in multi-gigabit optical coherent receivers. We present simulation results of bit error rate (BER) for non-differential polarization division multiplexing (PDM)-16QAM modulation in a 200 Gb/s coherent optical system that includes an LDPC code with 20% overhead and net coding gain of 11.3 dB at BER = 10-15. Our study shows that JIDD with a pilot rate ⩽ 5 % compensates for both laser phase noise and laser frequency fluctuation. Furthermore, since JIDD is used with non-differential modulation formats, we find that gains in excess of 1 dB can be achieved over existing solutions based on an explicit carrier phase estimator with differential modulation. The impact of the fiber nonlinearities in dense wavelength division multiplexing (DWDM) systems is also investigated. Our results demonstrate that JIDD is an excellent candidate for application in next generation high-speed optical coherent receivers.

  7. Least-squares Migration and Full Waveform Inversion with Multisource Frequency Selection

    KAUST Repository

    Huang, Yunsong

    2013-09-01

    Multisource Least-Squares Migration (LSM) of phase-encoded supergathers has shown great promise in reducing the computational cost of conventional migration. But for the marine acquisition geometry this approach faces the challenge of erroneous misfit due to the mismatch between the limited number of live traces/shot recorded in the field and the pervasive number of traces generated by the finite-difference modeling method. To tackle this mismatch problem, I present a frequency selection strategy with LSM of supergathers. The key idea is, at each LSM iteration, to assign a unique frequency band to each shot gather, so that the spectral overlap among those shots—and therefore their crosstallk—is zero. Consequently, each receiver can unambiguously identify and then discount the superfluous sources—those that are not associated with the receiver in marine acquisition. To compare with standard migration, I apply the proposed method to 2D SEG/EAGE salt model and obtain better resolved images computed at about 1/8 the cost; results for 3D SEG/EAGE salt model, with Ocean Bottom Seismometer (OBS) survey, show a speedup of 40×. This strategy is next extended to multisource Full Waveform Inversion (FWI) of supergathers for marine streamer data, with the same advantages of computational efficiency and storage savings. In the Finite-Difference Time-Domain (FDTD) method, to mitigate spectral leakage due to delayed onsets of sine waves detected at receivers, I double the simulation time and retain only the second half of the simulated records. To compare with standard FWI, I apply the proposed method to 2D velocity model of SEG/EAGE salt and to Gulf Of Mexico (GOM) field data, and obtain a speedup of about 4× and 8×. Formulas are then derived for the resolution limits of various constituent wavepaths pertaining to FWI: diving waves, primary reflections, diffractions, and multiple reflections. They suggest that inverting multiples can provide some low and intermediate

  8. Triphenylphosphine oxide is a potent and selective inhibitor of the transient receptor potential melastatin-5 ion channel.

    Science.gov (United States)

    Palmer, R Kyle; Atwal, Karnail; Bakaj, Ivona; Carlucci-Derbyshire, Stacy; Buber, M Tulu; Cerne, Rok; Cortés, Rosa Y; Devantier, Heather R; Jorgensen, Vincent; Pawlyk, Aaron; Lee, S Paul; Sprous, Dennis G; Zhang, Zheng; Bryant, Robert

    2010-12-01

    Transient receptor potential melastatin-5 (TRPM5) is a calcium-gated monovalent cation channel expressed in highly specialized cells of the taste bud and gastrointestinal tract, as well as in pancreatic β-cells. Well established as a critical signaling protein for G protein-coupled receptor-mediated taste pathways, TRPM5 also has recently been implicated as a regulator of incretin and insulin secretion. To date, no inhibitors of practical use have been described that could facilitate investigation of TRPM5 functions in taste or secretion of metabolic hormones. Using recombinant TRPM5-expressing cells in a fluorescence imaging plate reader-based membrane potential assay, we identified triphenylphosphine oxide (TPPO) as a selective and potent inhibitor of TRPM5. TPPO inhibited both human (IC₅₀ = 12 μM) and murine TRPM5 (IC₅₀ = 30 μM) heterologously expressed in HEK293 cells, but had no effect (up to 100 μM) on the membrane potential responses of TRPA1, TRPV1, or TRPM4b. TPPO also inhibited a calcium-gated TRPM5-dependent conductance in taste cells isolated from the tongues of transgenic TRPM5(+/)⁻ mice. In contrast, TPP had no effect on TRPM5 responses, indicating a strict requirement of the oxygen atom for activity. Sixteen additional TPPO derivatives also inhibited TRPM5 but none more potently than TPPO. Structure-activity relationship of tested compounds was used for molecular modeling-based analysis to clarify the positive and negative structural contributions to the potency of TPPO and its derivatives. TPPO is the most potent TRPM5 inhibitor described to date and is the first demonstrated to exhibit selectivity over other channels.

  9. Joint random beam and spectrum selection for spectrum sharing systems with partial channel state information

    KAUST Repository

    Abdallah, Mohamed M.

    2013-11-01

    In this work, we develop joint interference-aware random beam and spectrum selection scheme that provide enhanced performance for the secondary network under the condition that the interference observed at the primary receiver is below a predetermined acceptable value. We consider a secondary link composed of a transmitter equipped with multiple antennas and a single-antenna receiver sharing the same spectrum with a set of primary links composed of a single-antenna transmitter and a single-antenna receiver. The proposed schemes jointly select a beam, among a set of power-optimized random beams, as well as the primary spectrum that maximizes the signal-to-interference-plus-noise ratio (SINR) of the secondary link while satisfying the primary interference constraint. In particular, we consider the case where the interference level is described by a q-bit description of its magnitude, whereby we propose a technique to find the optimal quantizer thresholds in a mean square error (MSE) sense. © 2013 IEEE.

  10. Forward-Masked Frequency Selectivity Improvements in Simulated and Actual Cochlear Implant Users Using a Preprocessing Algorithm

    Directory of Open Access Journals (Sweden)

    Florian Langner

    2016-07-01

    Full Text Available Frequency selectivity can be quantified using masking paradigms, such as psychophysical tuning curves (PTCs. Normal-hearing (NH listeners show sharp PTCs that are level- and frequency-dependent, whereas frequency selectivity is strongly reduced in cochlear implant (CI users. This study aims at (a assessing individual shapes of PTCs in CI users, (b comparing these shapes to those of simulated CI listeners (NH listeners hearing through a CI simulation, and (c increasing the sharpness of PTCs using a biologically inspired dynamic compression algorithm, BioAid, which has been shown to sharpen the PTC shape in hearing-impaired listeners. A three-alternative-forced-choice forward-masking technique was used to assess PTCs in 8 CI users (with their own speech processor and 11 NH listeners (with and without listening through a vocoder to simulate electric hearing. CI users showed flat PTCs with large interindividual variability in shape, whereas simulated CI listeners had PTCs of the same average flatness, but more homogeneous shapes across listeners. The algorithm BioAid was used to process the stimuli before entering the CI users’ speech processor or the vocoder simulation. This algorithm was able to partially restore frequency selectivity in both groups, particularly in seven out of eight CI users, meaning significantly sharper PTCs than in the unprocessed condition. The results indicate that algorithms can improve the large-scale sharpness of frequency selectivity in some CI users. This finding may be useful for the design of sound coding strategies particularly for situations in which high frequency selectivity is desired, such as for music perception.

  11. An Approach to Near Field Data Selection in Radio Frequency Identification

    Science.gov (United States)

    Winkworth, Robert D.

    Personal identification is needed in many civil activities, and the common identification cards, such as a driver's license, have become the standard document de facto. Radio frequency identification has complicated this matter. Unlike their printed predecessors, contemporary RFID cards lack a practical way for users to control access to their individual fields of data. This leaves them more available to unauthorized parties, and more prone to abuse. Here, then was undertaken a means to test a novel RFID card technology that allows overlays to be used for reliable, reversible data access settings. Similar to other proposed switching mechanisms, it offers advantages that may greatly improve outcomes. RFID use is increasing in identity documents such as drivers' licenses and passports, and with it concern over the theft of personal information, which can enable unauthorized tracking or fraud. Effort put into designing a strong foundation technology now may allow for widespread development on them later. In this dissertation, such a technology was designed and constructed, to drive the central thesis that selective detuning could serve as a feasible, reliable mechanism. The concept had been illustrated effective in limiting access to all fields simultaneously before, and was here effective in limiting access to specific fields selectively. A novel card was produced in familiar dimensions, with an intuitive interface by which users may conceal the visible print of the card to conceal the wireless emissions it allows. A discussion was included of similar technologies, involving capacitive switching, that could further improve the outcomes if such a product were put to large-scale commercial fabrication. The card prototype was put to a battery of laboratory tests to measure the degree of independence between data fields and the reliability of the switching mechanism when used under realistically variable coverage, demonstrating statistically consistent performance in

  12. Digital halftoning methods for selectively partitioning error into achromatic and chromatic channels

    Science.gov (United States)

    Mulligan, Jeffrey B.

    1990-01-01

    A method is described for reducing the visibility of artifacts arising in the display of quantized color images on CRT displays. The method is based on the differential spatial sensitivity of the human visual system to chromatic and achromatic modulations. Because the visual system has the highest spatial and temporal acuity for the luminance component of an image, a technique which will reduce luminance artifacts at the expense of introducing high-frequency chromatic errors is sought. A method based on controlling the correlations between the quantization errors in the individual phosphor images is explored. The luminance component is greatest when the phosphor errors are positively correlated, and is minimized when the phosphor errors are negatively correlated. The greatest effect of the correlation is obtained when the intensity quantization step sizes of the individual phosphors have equal luminances. For the ordered dither algorithm, a version of the method can be implemented by simply inverting the matrix of thresholds for one of the color components.

  13. Heat transfer in plate heat exchanger channels: Experimental validation of selected correlation equations

    Directory of Open Access Journals (Sweden)

    Cieśliński Janusz T.

    2016-09-01

    Full Text Available This study is focused on experimental investigation of selected type of brazed plate heat exchanger (PHEx. The Wilson plot approach was applied in order to estimate heat transfer coefficients for the PHEx passages. The main aim of the paper was to experimentally check ability of several correlations published in the literature to predict heat transfer coefficients by comparison experimentally obtained data with appropriate predictions. The results obtained revealed that Hausen and Dittus-Boelter correlations underestimated heat transfer coefficient for the tested PHEx by an order of magnitude. The Aspen Plate code overestimated heat transfer coefficient by about 50%, while Muley-Manglik correlation overestimated it from 1% to 25%, dependent on the value of Reynolds number and hot or cold liquid side.

  14. Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels.

    Science.gov (United States)

    Klint, Julie K; Berecki, Géza; Durek, Thomas; Mobli, Mehdi; Knapp, Oliver; King, Glenn F; Adams, David J; Alewood, Paul F; Rash, Lachlan D

    2014-05-15

    Spider venoms are replete with peptidic ion channel modulators, often with novel subtype selectivity, making them a rich source of pharmacological tools and drug leads. In a search for subtype-selective blockers of voltage-gated calcium (CaV) channels, we isolated and characterized a novel 39-residue peptide, ω-TRTX-Cc1a (Cc1a), from the venom of the tarantula Citharischius crawshayi (now Pelinobius muticus). Cc1a is 67% identical to the spider toxin ω-TRTX-Hg1a, an inhibitor of CaV2.3 channels. We assembled Cc1a using a combination of Boc solid-phase peptide synthesis and native chemical ligation. Oxidative folding yielded two stable, slowly interconverting isomers. Cc1a preferentially inhibited Ba(2+) currents (IBa) mediated by L-type (CaV1.2 and CaV1.3) CaV channels heterologously expressed in Xenopus oocytes, with half-maximal inhibitory concentration (IC50) values of 825nM and 2.24μM, respectively. In rat dorsal root ganglion neurons, Cc1a inhibited IBa mediated by high voltage-activated CaV channels but did not affect low voltage-activated T-type CaV channels. Cc1a exhibited weak activity at NaV1.5 and NaV1.7 voltage-gated sodium (NaV) channels stably expressed in mammalian HEK or CHO cells, respectively. Experiments with modified Cc1a peptides, truncated at the N-terminus (ΔG1-E5) or C-terminus (ΔW35-V39), demonstrated that the N- and C-termini are important for voltage-gated ion channel modulation. We conclude that Cc1a represents a novel pharmacological tool for probing the structure and function of L-type CaV channels. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Mixed Stimulus-Induced Mode Selection in Neural Activity Driven by High and Low Frequency Current under Electromagnetic Radiation

    Directory of Open Access Journals (Sweden)

    Lulu Lu

    2017-01-01

    Full Text Available The electrical activities of neurons are dependent on the complex electrophysiological condition in neuronal system, the three-variable Hindmarsh-Rose (HR neuron model is improved to describe the dynamical behaviors of neuronal activities with electromagnetic induction being considered, and the mode transition of electrical activities in neuron is detected when external electromagnetic radiation is imposed on the neuron. In this paper, different types of electrical stimulus impended with a high-low frequency current are imposed on new HR neuron model, and mixed stimulus-induced mode selection in neural activity is discussed in detail. It is found that mode selection of electrical activities stimulated by high-low frequency current, which also changes the excitability of neuron, can be triggered owing to adding the Gaussian white noise. Meanwhile, the mode selection of the neuron electrical activity is much dependent on the amplitude B of the high frequency current under the same noise intensity, and the high frequency response is selected preferentially by applying appropriate parameters and noise intensity. Our results provide insights into the transmission of complex signals in nerve system, which is valuable in engineering prospective applications such as information encoding.

  16. Is the colour dimorphism in Dactylorhiza sambucina maintained by differential seed viability instead of frequency-dependent selection?

    Czech Academy of Sciences Publication Activity Database

    Jersáková, Jana; Kindlmann, Pavel; Renner, S.S.

    2006-01-01

    Roč. 41, - (2006), s. 61-76 ISSN 0015-5551 R&D Projects: GA AV ČR(CZ) KJB6141302 Keywords : Dactylorhiza * flower colour polymorphism * frequency-dependent selection * pollinator discrimination * rewardless flowers * seed viability Subject RIV: EF - Botanics Impact factor: 1.033, year: 2005

  17. Monitoring devices and systems for monitoring frequency hopping wireless communications, and related methods

    Science.gov (United States)

    Derr, Kurt W.; Richardson, John G.

    2017-05-02

    Monitoring devices and systems comprise a plurality of data channel modules coupled to processing circuitry. Each data channel module of the plurality of data channel modules is configured to capture wireless communications for a selected frequency channel. The processing circuitry is configured to receive captured wireless communications from the plurality of data channel modules and to organize received wireless communications according to at least one parameter. Related methods of monitoring wireless communications are also disclosed.

  18. Selective electrochemical detection of dopamine in a microfluidic channel on carbon nanoparticulate electrodes.

    Science.gov (United States)

    Rozniecka, Ewa; Jonsson-Niedziolka, Martin; Celebanska, Anna; Niedziolka-Jonsson, Joanna; Opallo, Marcin

    2014-06-07

    There is a continuous need for the construction of detection systems in microfluidic devices. In particular, electrochemical detection allows the separation of signals from the analyte and interfering substances in the potential domain. Here, a simple microfluidic device for the sensitive and selective determination of dopamine in the presence of interfering substances was constructed and tested. It employs a carbon nanoparticulate electrode allowing the separation of voltammetric signals of dopamine and common interfering substances (ascorbic acid and acetaminophen) both in quiescent conditions and in flow due to the electrocatalytic effect. These voltammograms were also successfully simulated. The limit of detection of dopamine detected by square wave voltammetry in 1 mM solutions of interfering substances in phosphate buffered saline is about 100 nM. In human serum a clear voltammetric signal could be seen for a 200 nM solution, sufficient to detect dopamine in the cerebral fluid. Flow injection analysis allows a decrease in the limit of detection down to 3.5 nM.

  19. Corynebacterium jeikeium jk0268 constitutes for the 40 amino acid long PorACj, which forms a homooligomeric and anion-selective cell wall channel.

    Directory of Open Access Journals (Sweden)

    Narges Abdali

    Full Text Available Corynebacterium jeikeium, a resident of human skin, is often associated with multidrug resistant nosocomial infections in immunodepressed patients. C. jeikeium K411 belongs to mycolic acid-containing actinomycetes, the mycolata and contains a channel-forming protein as judged from reconstitution experiments with artificial lipid bilayer experiments. The channel-forming protein was present in detergent treated cell walls and in extracts of whole cells using organic solvents. A gene coding for a 40 amino acid long polypeptide possibly responsible for the pore-forming activity was identified in the known genome of C. jeikeium by its similar chromosomal localization to known porH and porA genes of other Corynebacterium strains. The gene jk0268 was expressed in a porin deficient Corynebacterium glutamicum strain. For purification temporarily histidine-tailed or with a GST-tag at the N-terminus, the homogeneous protein caused channel-forming activity with an average conductance of 1.25 nS in 1M KCl identical to the channels formed by the detergent extracts. Zero-current membrane potential measurements of the voltage dependent channel implied selectivity for anions. This preference is according to single-channel analysis caused by some excess of cationic charges located in the channel lumen formed by oligomeric alpha-helical wheels. The channel has a suggested diameter of 1.4 nm as judged from the permeability of different sized hydrated anions using the Renkin correction factor. Surprisingly, the genome of C. jeikeium contained only one gene coding for a cell wall channel of the PorA/PorH type found in other Corynebacterium species. The possible evolutionary relationship between the heterooligomeric channels formed by certain Corynebacterium strains and the homooligomeric pore of C. jeikeium is discussed.

  20. Comparative effects of oil palm and selective logging on erosion, river channels and water chemistry in Malaysian steeplands

    Science.gov (United States)

    Walsh, Rory; Nainar, Anand; Nurhidayu, Siti; Higton, Sam; Annammala, Kogilavani; Wall, Katy; Bidin, Kawi; Blake, William; Darling, Isabella

    2017-04-01

    Oil palm land-use has expanded greatly in recent decades in SE Asia and other parts of the wet tropics, including to steepland areas, where bench-terraced landscaping is involved. Retaining (and sometimes restoring) riparian forest strips and rainforest fragments on the steepest slopes have been adopted as elements of strategies designed to reduce adverse effects on runoff generation, erosion, downstream sedimentation, flooding and pollutional problems - as well as biodiversity and emissions. Results of catchment monitoring, soil erosion and sediment fingerprinting research in oil palm and selectively logged steeplands of eastern Sabah and Peninsular Malaysia are presented. The evidence indicates the greater scale and temporal persistence of effects that oil palm land-use (compared with selective logging) has had on suspended sediment dynamics, soil erosion, downstream sedimentation, channel geometry and dynamics and river pollution. The importance of (1) high densities of roads and tracks and (2) relatively impermeable bench-terraced terrain in enhancing runoff, sediment and nutrient outputs in storm events is stressed. Influences of oil palm management practices including riparian forest strips in increasing or reducing these effects are critically reviewed and ways of increasing the effectiveness of riparian forest strips are proposed. The design and rationale of current projects exploring and testing consequences of existing and proposed improved land management practices are briefly described. The key importance of involvement of people from the oil palm industry (including multinational companies, smallholders and their organizations) and Government bodies that are responsible for land-use policies and land management practices is stressed.

  1. Integration of Frequency Domain Wideband Antenna Nulling and Wavenumber Domain Image Formation for Multi-Channel SAR

    Directory of Open Access Journals (Sweden)

    M. Bucciarelli

    2016-01-01

    Full Text Available A Multichannel Synthetic Aperture Radar (M-SAR exploiting an antenna nulling based Electronic Counter-Counter Measures (ECCM technique shall be able to cancel the effects of noise-like interferences over the collected SAR data. Since SAR systems often work with wide bandwidths to provide high resolution images, ECCM technique must account for the presence of wideband interference signal. In this paper we consider a wideband antenna nulling technique based on space-frequency adaptive nulling and we propose an integration of the WB antenna nulling scheme within the focusing algorithm for M-SAR systems, thus allowing a fusion between ECCM and usual SAR processing steps. The computational cost of the integrated algorithm is compared with the cost of more traditional sequence of the wideband extension of the Side-Lobe Canceller and the focusing operation, to show the computational feasibility of the proposed integrated algorithm. The possibility to perform suboptimally the space-frequency adaptive nulling is also considered.

  2. Comparing the effects of genetic drift and fluctuating selection on genotype frequency changes in the scarlet tiger moth.

    Science.gov (United States)

    O'Hara, R B

    2005-01-22

    One of the recurring arguments in evolutionary biology is whether evolution occurs principally through natural selection or through neutral processes such as genetic drift. A 60-year-long time series of changes in the genotype frequency of a colour polymorphism of the scarlet tiger moth, Callimorpha dominula, was used to compare the relative effects of genetic drift and variable natural selection. The analysis showed that most of the variation in frequency was the result of genetic drift. In addition, although selection was acting, mean fitness barely increased. This supports the 'Red Queen's hypothesis' that long-term improvements in fitness may not occur, because populations have to keep pace with changes in the environment.

  3. Inkjet printed paper based frequency selective surfaces and skin mounted RFID tags: The interrelation between silver nanoparticle ink, paper substrate and low temperature sintering technique

    NARCIS (Netherlands)

    Sanchez-Romaguera, V.; Wünscher, S.; Turki, B.M.; Abbel, R.; Barbosa, S.; Tate, D.J.; Oyeka, D.; Batchelor, J.C.; Parker, E.A.; Schubert, U.S.; Yeates, S.G.

    2015-01-01

    Inkjet printing of functional frequency selective surfaces (FSS) and radio frequency identification (RFID) tags on commercial paper substrates using silver nanoparticle inks sintered using low temperature thermal, plasma and photonic techniques is reported. Printed and sintered FSS devices

  4. Efficient collaborative sparse channel estimation in massive MIMO

    KAUST Repository

    Masood, Mudassir

    2015-08-12

    We propose a method for estimation of sparse frequency selective channels within MIMO-OFDM systems. These channels are independently sparse and share a common support. The method estimates the impulse response for each channel observed by the antennas at the receiver. Estimation is performed in a coordinated manner by sharing minimal information among neighboring antennas to achieve results better than many contemporary methods. Simulations demonstrate the superior performance of the proposed method.

  5. The Selective Late Sodium Current Inhibitor Eleclazine, Unlike Amiodarone, Does Not Alter Defibrillation Threshold or Dominant Frequency of Ventricular Fibrillation.

    Science.gov (United States)

    Silva, Ana F G; Bonatti, Rodolfo; Batatinha, Julio A P; Nearing, Bruce D; Zeng, Dewan; Belardinelli, Luiz; Verrier, Richard L

    2017-03-01

    We examined the effects of the selective late INa inhibitor eleclazine on the 50% probability of successful defibrillation (DFT50) before and after administration of amiodarone to determine its suitability for use in patients with implantable cardioverter defibrillators (ICDs). In 20 anesthetized pigs, transvenous active-fixation cardiac defibrillation leads were fluoroscopically positioned into right ventricular apex through jugular vein. ICDs were implanted subcutaneously. Dominant frequency of ventricular fibrillation was analyzed by fast Fourier transform. The measurements were made before drug administration (control), and at 40 minutes after vehicle, eleclazine (2 mg/kg, i.v., bolus over 15 minutes), or subsequent/single amiodarone administration (10 mg/kg, i.v., bolus over 10 minutes). Eleclazine did not alter DFT50, dominant frequency, heart rate, or mean arterial pressure (MAP). Subsequent amiodarone increased DFT50 (P = 0.006), decreased dominant frequency (P = 0.022), and reduced heart rate (P = 0.031) with no change in MAP. Amiodarone alone increased DFT50 (P = 0.005; NS compared to following eleclazine) and decreased dominant frequency (P = 0.003; NS compared to following eleclazine). Selective late INa inhibition with eleclazine does not alter DFT50 or dominant frequency of ventricular fibrillation when administered alone or in combination with amiodarone. Accordingly, eleclazine would not be anticipated to affect the margin of defibrillation safety in patients with ICDs.

  6. Frequency Selective Energy Transport of the Copper Nanowire Driven by External Force

    Science.gov (United States)

    Zhong, Wei-Rong; Ai, Bao-Quan; Shao, Yuan-Zhi

    2011-07-01

    We study the energy transport in the copper nanowire driven by a Z-direction periodic vibration through nonequilibrium molecular-dynamics simulations. It is observed that the energy transport is dependence on the frequency of the periodic vibration. This phenomenon can be explained by the matches between the phonon spectra of the particle and the external vibration. It is suggested that the energy flux flowing through the copper nanowire can be controlled by applying high frequency external driven forces.

  7. Autonomous generator based on Ni-Mn-Ga microactuator as a frequency selective element

    Directory of Open Access Journals (Sweden)

    Barandiaran J.M.

    2013-01-01

    Full Text Available In this work, we suggest the temperature-induced resistivity change at the martensitic transformation in the Ni-Mn-Ga ferromagnetic shape memory alloy as a driving mechanism enabling periodic signal generation. We demonstrated its practical importance by a design of the prototype of a low-frequency autonomous generator. A prominent feature of this new generator is a control of its frequency by the external magnetic field.

  8. An Approach for Synthesis of Modulated M-Channel FIR Filter Banks Utilizing the Frequency-Response Masking Technique

    Directory of Open Access Journals (Sweden)

    Håkan Johansson

    2007-01-01

    Full Text Available The frequency-response masking (FRM technique was introduced as a means of generating linear-phase FIR filters with narrow transition band and low arithmetic complexity. This paper proposes an approach for synthesizing modulated maximally decimated FIR filter banks (FBs utilizing the FRM technique. A new tailored class of FRM filters is introduced and used for synthesizing nonlinear-phase analysis and synthesis filters. Each of the analysis and synthesis FBs is realized with the aid of only three subfilters, one cosine-modulation block, and one sine-modulation block. The overall FB is a near-perfect reconstruction (NPR FB which in this case means that the distortion function has a linear-phase response but small magnitude errors. Small aliasing errors are also introduced by the FB. However, by allowing these small errors (that can be made arbitrarily small, the arithmetic complexity can be reduced. Compared to conventional cosine-modulated FBs, the proposed ones lower significantly the overall arithmetic complexity at the expense of a slightly increased overall FB delay in applications requiring narrow transition bands. Compared to other proposals that also combine cosine-modulated FBs with the FRM technique, the arithmetic complexity can typically be reduced by 40% in specifications with narrow transition bands. Finally, a general design procedure is given for the proposed FBs and examples are included to illustrate their benefits.

  9. An Approach for Synthesis of Modulated -Channel FIR Filter Banks Utilizing the Frequency-Response Masking Technique

    Directory of Open Access Journals (Sweden)

    Rosenbaum Linnéa

    2007-01-01

    Full Text Available The frequency-response masking (FRM technique was introduced as a means of generating linear-phase FIR filters with narrow transition band and low arithmetic complexity. This paper proposes an approach for synthesizing modulated maximally decimated FIR filter banks (FBs utilizing the FRM technique. A new tailored class of FRM filters is introduced and used for synthesizing nonlinear-phase analysis and synthesis filters. Each of the analysis and synthesis FBs is realized with the aid of only three subfilters, one cosine-modulation block, and one sine-modulation block. The overall FB is a near-perfect reconstruction (NPR FB which in this case means that the distortion function has a linear-phase response but small magnitude errors. Small aliasing errors are also introduced by the FB. However, by allowing these small errors (that can be made arbitrarily small, the arithmetic complexity can be reduced. Compared to conventional cosine-modulated FBs, the proposed ones lower significantly the overall arithmetic complexity at the expense of a slightly increased overall FB delay in applications requiring narrow transition bands. Compared to other proposals that also combine cosine-modulated FBs with the FRM technique, the arithmetic complexity can typically be reduced by in specifications with narrow transition bands. Finally, a general design procedure is given for the proposed FBs and examples are included to illustrate their benefits.

  10. Reply to Comment on ‘Encoding many channels on the same frequency through radio vorticity: first experimental test’

    International Nuclear Information System (INIS)

    Tamburini, F; Sponselli, A; Bianchini, A; Thidé, B; Mari, E; Romanato, F

    2012-01-01

    Our recent paper (Tamburini et al 2012 New J. Phys. 14 033001), which presented results from outdoor experiments that demonstrate that it is physically feasible to simultaneously transmit different states of the newly recognized electromagnetic (EM) quantity orbital angular momentum (OAM) at radio frequencies into the far zone and to identify these states there, has led to a comment (Tamagnone et al 2012 New J. Phys. 14 118001). These authors discuss whether our investigations can be regarded as a particular implementation of the multiple-input–multiple-output (MIMO) technique. Clearly, our experimental confirmation of a theoretical prediction, first made almost a century ago (Abraham 1914 Phys. Z. XV 914–8), that the total EM angular momentum (a pseudovector of dimension length × mass × velocity) can propagate over huge distances, is essentially different from—and conceptually incompatible with—the fact that there exist engineering techniques that can enhance the spectral capacity of EM linear momentum (an ordinary vector of dimension mass × velocity). Our OAM experiments (Tamburini et al 2012 New J. Phys. 14 033001; Tamburini et al 2011 Appl. Phys. Lett. 99 204102–3) confirm the availability of a new physical layer for real-world radio communications based on EM rotational degrees of freedom. The next step is to develop new protocols and techniques for high spectral density on this new physical layer. This includes MIMO-like and other, more efficient, techniques. (reply to comment)

  11. Modeling coverage gaps in haplotype frequencies via Bayesian inference to improve stem cell donor selection.

    Science.gov (United States)

    Louzoun, Yoram; Alter, Idan; Gragert, Loren; Albrecht, Mark; Maiers, Martin

    2018-05-01

    Regardless of sampling depth, accurate genotype imputation is limited in regions of high polymorphism which often have a heavy-tailed haplotype frequency distribution. Many rare haplotypes are thus unobserved. Statistical methods to improve imputation by extending reference haplotype distributions using linkage disequilibrium patterns that relate allele and haplotype frequencies have not yet been explored. In the field of unrelated stem cell transplantation, imputation of highly polymorphic human leukocyte antigen (HLA) genes has an important application in identifying the best-matched stem cell donor when searching large registries totaling over 28,000,000 donors worldwide. Despite these large registry sizes, a significant proportion of searched patients present novel HLA haplotypes. Supporting this observation, HLA population genetic models have indicated that many extant HLA haplotypes remain unobserved. The absent haplotypes are a significant cause of error in haplotype matching. We have applied a Bayesian inference methodology for extending haplotype frequency distributions, using a model where new haplotypes are created by recombination of observed alleles. Applications of this joint probability model offer significant improvement in frequency distribution estimates over the best existing alternative methods, as we illustrate using five-locus HLA frequency data from the National Marrow Donor Program registry. Transplant matching algorithms and disease association studies involving phasing and imputation of rare variants may benefit from this statistical inference framework.

  12. Cooperative AF Relaying in Spectrum-Sharing Systems: Outage Probability Analysis under Co-Channel Interferences and Relay Selection

    KAUST Repository

    Xia, Minghua

    2012-11-01

    For cooperative amplify-and-forward (AF) relaying in spectrum-sharing wireless systems, secondary users share spectrum resources originally licensed to primary users to communicate with each other and, thus, the transmit power of secondary transmitters is strictly limited by the tolerable interference powers at primary receivers. Furthermore, the received signals at a relay and at a secondary receiver are inevitably interfered by the signals from primary transmitters. These co-channel interferences (CCIs) from concurrent primary transmission can significantly degrade the performance of secondary transmission. This paper studies the effect of CCIs on outage probability of the secondary link in a spectrum-sharing environment. In particular, in order to compensate the performance loss due to CCIs, the transmit powers of a secondary transmitter and its relaying node are respectively optimized with respect to both the tolerable interference powers at the primary receivers and the CCIs from the primary transmitters. Moreover, when multiple relays are available, the technique of opportunistic relay selection is exploited to further improve system performance with low implementation complexity. By analyzing lower and upper bounds on the outage probability of the secondary system, this study reveals that it is the tolerable interference powers at primary receivers that dominate the system performance, rather than the CCIs from primary transmitters. System designers will benefit from this result in planning and designing next-generation broadband spectrum-sharing systems.

  13. Saccade frequency response to visual cues during gait in Parkinson's disease: the selective role of attention.

    Science.gov (United States)

    Stuart, Samuel; Lord, Sue; Galna, Brook; Rochester, Lynn

    2018-02-12

    Gait impairment is a core feature of Parkinson's disease (PD) with implications for falls risk. Visual cues improve gait in PD, but the underlying mechanisms are unclear. Evidence suggests that attention and vision play an important role; however, the relative contribution from each is unclear. Measurement of visual exploration (specifically saccade frequency) during gait allows for real-time measurement of attention and vision. Understanding how visual cues influence visual exploration may allow inferences of the underlying mechanisms to response which could help to develop effective therapeutics. This study aimed to examine saccade frequency during gait in response to a visual cue in PD and older adults and investigate the roles of attention and vision in visual cue response in PD. A mobile eye-tracker measured saccade frequency during gait in 55 people with PD and 32 age-matched controls. Participants walked in a straight line with and without a visual cue (50 cm transverse lines) presented under single task and dual-task (concurrent digit span recall). Saccade frequency was reduced when walking in PD compared to controls; however, visual cues ameliorated saccadic deficit. Visual cues significantly increased saccade frequency in both PD and controls under both single task and dual-task. Attention rather than visual function was central to saccade frequency and gait response to visual cues in PD. In conclusion, this study highlights the impact of visual cues on visual exploration when walking and the important role of attention in PD. Understanding these complex features will help inform intervention development. © 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  14. Wide-range frequency selectivity in an acoustic sensor fabricated using a microbeam array with non-uniform thickness

    International Nuclear Information System (INIS)

    Shintaku, Hirofumi; Kotera, Hidetoshi; Kobayashi, Takayuki; Zusho, Kazuki; Kawano, Satoyuki

    2013-01-01

    In this study, we have demonstrated the fabrication of a microbeam array (MBA) with various thicknesses and investigated the suitability it for an acoustic sensor with wide-range frequency selectivity. For this, an MBA composed of 64 beams, with thicknesses varying from 2.99–142 µm, was fabricated by using single gray-scale lithography and a thick negative photoresist. The vibration of the beams in air was measured using a laser Doppler vibrometer; the resonant frequencies of the beams were measured to be from 11.5 to 290 kHz. Lastly, the frequency range of the MBA with non-uniform thickness was 10.9 times that of the MBA with uniform thickness. (paper)

  15. Selection of the wavelet function for the frequencies estimation; Seleccion de la funcion wavelet para la estimacion de frecuencias

    Energy Technology Data Exchange (ETDEWEB)

    Garcia R, A. [ININ, Carretera Mexico-Toluca S/N, 52750 La Marquesa, Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: ramador@nuclear.inin.mx

    2007-07-01

    At the moment the signals are used to diagnose the state of the systems, by means of the extraction of their more important characteristics such as the frequencies, tendencies, changes and temporary evolutions. This characteristics are detected by means of diverse analysis techniques, as Autoregressive methods, Fourier Transformation, Fourier transformation in short time, Wavelet transformation, among others. The present work uses the one Wavelet transformation because it allows to analyze stationary, quasi-stationary and transitory signals in the time-frequency plane. It also describes a methodology to select the scales and the Wavelet function to be applied the one Wavelet transformation with the objective of detecting to the dominant system frequencies. (Author)

  16. Iterative Pilot-Layer Aided Channel Estimation with Emphasis on Interleave-Division Multiple Access Systems

    OpenAIRE

    Schoeneich Hendrik; Hoeher Peter Adam

    2006-01-01

    Channel estimation schemes suitable for interleave-division multiple access (IDMA) systems are presented. Training and data are superimposed. Training-based and semiblind linear channel estimators are derived and their performance is discussed and compared. Monte Carlo simulation results are presented showing that the derived channel estimators in conjunction with a superimposed pilot sequence and chip-by-chip processing are able to track fast-fading frequency-selective channels. As opposed ...

  17. Selecting informative food items for compiling food-frequency questionnaires: Comparison of procedures

    NARCIS (Netherlands)

    Molag, M.L.; Vries, J.H.M. de; Duif, N.; Ocké, M.C.; Dagnelie, P.C.; Goldbohm, R.A.; Veer, P. van 't

    2010-01-01

    The authors automated the selection of foods in a computer system that compiles and processes tailored FFQ. For the selection of food items, several methods are available. The aim of the present study was to compare food lists made by MOM2, which identifies food items with highest between-person

  18. Optimising the selection of food items for food frequency questionnaires using Mixed Integer Linear Programming

    NARCIS (Netherlands)

    Lemmen-Gerdessen, van J.C.; Souverein, O.W.; Veer, van 't P.; Vries, de J.H.M.

    2015-01-01

    Objective To support the selection of food items for FFQs in such a way that the amount of information on all relevant nutrients is maximised while the food list is as short as possible. Design Selection of the most informative food items to be included in FFQs was modelled as a Mixed Integer Linear

  19. The Villain as Reference Idol: Selection Frequencies and Salient Attributes among New Zealand Teenagers.

    Science.gov (United States)

    Melnick, Merrill J.; Jackson, Steven J.

    1998-01-01

    Teenagers responded to a questionnaire about their villains; 917 villains from all walks of life were selected. Nine times more male than female figures were selected. The naming of a villain was unrelated to demographic variables. Reasons for dislike and influence of figures as avoidance role models are discussed. (Author/EMK)

  20. Fringe order correction for the absolute phase recovered by two selected spatial frequency fringe projections in fringe projection profilometry.

    Science.gov (United States)

    Ding, Yi; Peng, Kai; Yu, Miao; Lu, Lei; Zhao, Kun

    2017-08-01

    The performance of the two selected spatial frequency phase unwrapping methods is limited by a phase error bound beyond which errors will occur in the fringe order leading to a significant error in the recovered absolute phase map. In this paper, we propose a method to detect and correct the wrong fringe orders. Two constraints are introduced during the fringe order determination of two selected spatial frequency phase unwrapping methods. A strategy to detect and correct the wrong fringe orders is also described. Compared with the existing methods, we do not need to estimate the threshold associated with absolute phase values to determine the fringe order error, thus making it more reliable and avoiding the procedure of search in detecting and correcting successive fringe order errors. The effectiveness of the proposed method is validated by the experimental results.

  1. Trade-offs between microbial growth phases lead to frequency-dependent and non-transitive selection.

    Science.gov (United States)

    Manhart, Michael; Adkar, Bharat V; Shakhnovich, Eugene I

    2018-02-14

    Mutations in a microbial population can increase the frequency of a genotype not only by increasing its exponential growth rate, but also by decreasing its lag time or adjusting the yield (resource efficiency). The contribution of multiple life-history traits to selection is a critical question for evolutionary biology as we seek to predict the evolutionary fates of mutations. Here we use a model of microbial growth to show that there are two distinct components of selection corresponding to the growth and lag phases, while the yield modulates their relative importance. The model predicts rich population dynamics when there are trade-offs between phases: multiple strains can coexist or exhibit bistability due to frequency-dependent selection, and strains can engage in rock-paper-scissors interactions due to non-transitive selection. We characterize the environmental conditions and patterns of traits necessary to realize these phenomena, which we show to be readily accessible to experiments. Our results provide a theoretical framework for analysing high-throughput measurements of microbial growth traits, especially interpreting the pleiotropy and correlations between traits across mutants. This work also highlights the need for more comprehensive measurements of selection in simple microbial systems, where the concept of an ordinary fitness landscape breaks down. © 2018 The Author(s).

  2. Independent, extensible control of same-frequency superconducting qubits by selective broadcasting

    NARCIS (Netherlands)

    Asaad, S.; Dickel, C.; Langford, N.K.; Poletto, S.; Bruno, A.; Rol, M.A.; Deurloo, D.; DiCarlo, L.

    2016-01-01

    A critical ingredient for realising large-scale quantum information processors will be the ability to make economical use of qubit control hardware. We demonstrate an extensible strategy for reusing control hardware on same-frequency transmon qubits in a circuit QED chip with surface-code-compatible

  3. FREQUENCY-SELECTIVE RESPONSE OF THE TECTORIAL MEMBRANE IN THE FROG BASILAR PAPILLA

    NARCIS (Netherlands)

    Schoffelen, R. L. M.; Segenhout, J. M.; van Dijk, P.; Cooper, NP; Kemp, DT

    2009-01-01

    The frog's basilar papilla is a useful study object for cochlear mechanics, because of it's relatively simple anatomy and functionality. We investigated the displacement amplitudes of the basilar papilla's tectorial membrane in response to stimulation of the oval window at various frequencies within

  4. Changes in cationic selectivity of the nicotinic channel at the rat ganglionic synapse: a role for chloride ions?

    Directory of Open Access Journals (Sweden)

    Oscar Sacchi

    Full Text Available The permeability of the nicotinic channel (nAChR at the ganglionic synapse has been examined, in the intact rat superior cervical ganglion in vitro, by fitting the Goldman current equation to the synaptic current (EPSC I-V relationship. Subsynaptic nAChRs, activated by neurally-released acetylcholine (ACh, were thus analyzed in an intact environment as natively expressed by the mature sympathetic neuron. Postsynaptic neuron hyperpolarization (from -40 to -90 mV resulted in a change of the synaptic potassium/sodium permeability ratio (P(K/P(Na from 1.40 to 0.92, corresponding to a reversible shift of the apparent acetylcholine equilibrium potential, E(ACh, by about +10 mV. The effect was accompanied by a decrease of the peak synaptic conductance (g(syn and of the EPSC decay time constant. Reduction of [Cl(-](o to 18 mM resulted in a change of P(K/P(Na from 1.57 (control to 2.26, associated with a reversible shift of E(ACh by about -10 mV. Application of 200 nM αBgTx evoked P(K/P(Na and g(syn modifications similar to those observed in reduced [Cl(-](o. The two treatments were overlapping and complementary, as if the same site/mechanism were involved. The difference current before and after chloride reduction or toxin application exhibited a strongly positive equilibrium potential, which could not be explained by the block of a calcium component of the EPSC. Observations under current-clamp conditions suggest that the driving force modification of the EPSC due to P(K/P(Na changes represent an additional powerful integrative mechanism of neuron behavior. A possible role for chloride ions is suggested: the nAChR selectivity was actually reduced by increased chloride gradient (membrane hyperpolarization, while it was increased, moving towards a channel preferentially permeable for potassium, when the chloride gradient was reduced.

  5. Changes in cationic selectivity of the nicotinic channel at the rat ganglionic synapse: a role for chloride ions?

    Science.gov (United States)

    Sacchi, Oscar; Rossi, Maria Lisa; Canella, Rita; Fesce, Riccardo

    2011-02-25

    The permeability of the nicotinic channel (nAChR) at the ganglionic synapse has been examined, in the intact rat superior cervical ganglion in vitro, by fitting the Goldman current equation to the synaptic current (EPSC) I-V relationship. Subsynaptic nAChRs, activated by neurally-released acetylcholine (ACh), were thus analyzed in an intact environment as natively expressed by the mature sympathetic neuron. Postsynaptic neuron hyperpolarization (from -40 to -90 mV) resulted in a change of the synaptic potassium/sodium permeability ratio (P(K)/P(Na)) from 1.40 to 0.92, corresponding to a reversible shift of the apparent acetylcholine equilibrium potential, E(ACh), by about +10 mV. The effect was accompanied by a decrease of the peak synaptic conductance (g(syn)) and of the EPSC decay time constant. Reduction of [Cl(-)](o) to 18 mM resulted in a change of P(K)/P(Na) from 1.57 (control) to 2.26, associated with a reversible shift of E(ACh) by about -10 mV. Application of 200 nM αBgTx evoked P(K)/P(Na) and g(syn) modifications similar to those observed in reduced [Cl(-)](o). The two treatments were overlapping and complementary, as if the same site/mechanism were involved. The difference current before and after chloride reduction or toxin application exhibited a strongly positive equilibrium potential, which could not be explained by the block of a calcium component of the EPSC. Observations under current-clamp conditions suggest that the driving force modification of the EPSC due to P(K)/P(Na) changes represent an additional powerful integrative mechanism of neuron behavior. A possible role for chloride ions is suggested: the nAChR selectivity was actually reduced by increased chloride gradient (membrane hyperpolarization), while it was increased, moving towards a channel preferentially permeable for potassium, when the chloride gradient was reduced.

  6. Historical Channel Adjustment and Estimates of Selected Hydraulic Values in the Lower Sabine River and Lower Brazos River Basins, Texas and Louisiana

    Science.gov (United States)

    Heitmuller, Franklin T.; Greene, Lauren E.

    2009-01-01

    The U.S. Geological Survey, in cooperation with the Texas Water Development Board, evaluated historical channel adjustment and estimated selected hydraulic values at U.S. Geological Survey streamflow-gaging stations in the lower Sabine River Basin in Texas and Louisiana and lower Brazos River Basin in Texas to support geomorphic assessments of the Texas Instream Flow Program. Channel attributes including cross-section geometry, slope, and planform change were evaluated to learn how each river's morphology changed over the years in response to natural and anthropogenic disturbances. Historical and contemporary cross-sectional channel geometries at several gaging stations on each river were compared, planform changes were assessed, and hydraulic values were estimated including mean flow velocity, bed shear stress, Froude numbers, and hydraulic depth. The primary sources of historical channel morphology information were U.S. Geological Survey hard-copy discharge-measurement field notes. Additional analyses were done using computations of selected flow hydraulics, comparisons of historical and contemporary aerial photographs, comparisons of historical and contemporary ground photographs, evaluations of how frequently stage-discharge rating curves were updated, reviews of stage-discharge relations for field measurements, and considerations of bridge and reservoir construction activities. Based on historical cross sections at three gaging stations downstream from Toledo Bend Reservoir, the lower Sabine River is relatively stable, but is subject to substantial temporary scour-and-fill processes during floods. Exceptions to this characterization of relative stability include an episode of channel aggradation at the Sabine River near Bon Wier, Texas, during the 1930s, and about 2 to 3 feet of channel incision at the Sabine River near Burkeville, Texas, since the late 1950s. The Brazos River, at gaging stations downstream from Waco, Texas, has adjusted to a combination of

  7. Price duration versus trading volume in high-frequency data for selected DAX companies

    Directory of Open Access Journals (Sweden)

    Christoph Mitterer

    2016-12-01

    Full Text Available The properties of the time series of durations between consecutive trades of a particular stock have been studied by many contributors in the literature of financial econometrics. Among them are highly prominent scientists like Engle (2000 and Gourieroux and Jasiak (2001. The importance of this topic, accompanied by the growing availability of (ultra-high-frequency data, has prompted an increase of contributions in recent years. Intensive research based on high-frequency data has several financial motivations. First of all, it is linked with microstructure theory. Secondly, it contributes to the literature on stochastic time deformation. But the most important need for research on the dynamics of trade durations is the necessity to manage liquidity risk. The reason is that durations between the following trades are a widely accepted measures of market liquidity. In addition, their volatility reflects the liquidity risk.

  8. Predicting the effect of relaxation during frequency-selective adiabatic pulses

    Science.gov (United States)

    Pfaff, Annalise R.; McKee, Cailyn E.; Woelk, Klaus

    2017-11-01

    Adiabatic half and full passages are invaluable for achieving uniform, B1-insensitive excitation or inversion of macroscopic magnetization across a well-defined range of NMR frequencies. To accomplish narrow frequency ranges with adiabatic pulses (computer-calculated data with experimental results demonstrates that, in non-viscous, small-molecule fluids, it is possible to model magnetization and relaxation by considering standard T1 and T2 relaxation in the traditional rotating frame. The proposed model is aimed at performance optimizations of applications in which these pulses are employed. It differs from previous reports which focused on short high-power adiabatic pulses and relaxation that is governed by dipole-dipole interactions, cross polarization, or chemical exchange.

  9. Low Intensity and Frequency Pulsed Electromagnetic Fields Selectively Impair Breast Cancer Cell Viability

    OpenAIRE

    Crocetti, Sara; Beyer, Christian; Schade, Grit; Egli, Marcel; Fr?hlich, J?rg; Franco-Obreg?n, Alfredo

    2013-01-01

    INTRODUCTION: A common drawback of many anticancer therapies is non-specificity in action of killing. We investigated the potential of ultra-low intensity and frequency pulsed electromagnetic fields (PEMFs) to kill breast cancer cells. Our criteria to accept this technology as a potentially valid therapeutic approach were: 1) cytotoxicity to breast cancer cells and; 2) that the designed fields proved innocuous to healthy cell classes that would be exposed to the PEMFs during clinical treatmen...

  10. Fluoroquinolone Enhances the Mutation Frequency for Meropenem-Selected Carbapenem Resistance in Pseudomonas aeruginosa, but Use of the High-Potency Drug Doripenem Inhibits Mutant Formation▿

    OpenAIRE

    Tanimoto, Koichi; Tomita, Haruyoshi; Fujimoto, Shuhei; Okuzumi, Katsuko; Ike, Yasuyoshi

    2008-01-01

    The mutation frequency for carbapenem resistance in Pseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increased mexAB-oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.

  11. Fluoroquinolone enhances the mutation frequency for meropenem-selected carbapenem resistance in Pseudomonas aeruginosa, but use of the high-potency drug doripenem inhibits mutant formation.

    Science.gov (United States)

    Tanimoto, Koichi; Tomita, Haruyoshi; Fujimoto, Shuhei; Okuzumi, Katsuko; Ike, Yasuyoshi

    2008-10-01

    The mutation frequency for carbapenem resistance in Pseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increased mexAB-oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.

  12. Online Optimal Switching Frequency Selection for Grid-Connected Voltage Source Inverters

    Directory of Open Access Journals (Sweden)

    Saher Albatran

    2017-12-01

    Full Text Available Enhancing the performance of the voltage source inverters (VSIs without changing the hardware structure has recently acquired an increased amount of interest. In this study, an optimization algorithm, enhancing the quality of the output power and the efficiency of three-phase grid connected VSIs is proposed. Towards that end, the proposed algorithm varies the switching frequency (fsw to maintain the best balance between switching losses of the insulated-gate-bipolar-transistor (IGBT power module as well as the output power quality under all loading conditions, including the ambient temperature effect. Since there is a contradiction with these two measures in relation to the switching frequency, the theory of multi-objective optimization is employed. The proposed algorithm is executed on the platform of Altera® DE2-115 field-programmable-gate-array (FPGA in which the optimal value of the switching frequency is determined online without the need for heavy offline calculations and/or lookup tables. With adopting the proposed algorithm, there is an improvement in the VSI efficiency without degrading the output power quality. Therefore, the proposed algorithm enhances the lifetime of the IGBT power module because of reduced variations in the module’s junction temperature. An experimental prototype is built, and experimental tests are conducted for the verification of the viability of the proposed algorithm.

  13. Investigation of Frequency-Domain Link Adaptation for a 5-MHz OFDMA/HSDPA system

    DEFF Research Database (Denmark)

    Pokhariyal, Akhilesh; Kolding, Troels E.; Frederiksen, Frank

    2005-01-01

    In this paper, we investigate frequency domain link adaptation (FDLA), e.g. utilizing the frequency selectivity of the channel in an OFDMA system. To make the study specific and based on realistic parameters, we re-use the specifications from a recent 3GPP 5-MHz OFDMA study item. The link...... adaptation and the frequency domain link adaptation are developed in a way compliant with the basic HSDPA specifications. With FDLA we show up to 75% cell throughput gain over the OFDMA reference system at the cost of increased uplink channel quality signaling overhead for frequency selective channels. We...

  14. A measurement of the top pair production cross-section in the dilepton channel using lepton plus track selection

    Energy Technology Data Exchange (ETDEWEB)

    Mills, Corrinne Elaine [Univ. of California, Santa Barbara, CA (United States)

    2007-06-01

    Using 1.1 fb-1 of data collected by the Collider Detector at Fermilab (CDF) from Run II of the Fermilab Tevatron, they measure the t$\\bar{t}$ production cross section in events with two leptons, significant missing transverse energy, and ≥ 2 jets. As the Run II dataset grows, more stringent tests of Standard Model predictions for the top quark sector are becoming possible. The dilepton channel, where both top quarks decay t → Wb → ℓvb, is of particular interest due to its high purity even in the absence of a b jet 'tagging' requirement. Use of an isolated track as the second lepton significant increases the dilepton acceptance, at the price of some increase in background, particular from W + jets events where one of the jets is identified as a lepton. With the amount of data available, it has been possible to improve the estimate of the contribution from that background, reflected in a reduced systematic uncertainty. Assuming a branching ratio of BR(W → ℓv) = 10.8% and a top mass of mt = 175 GeV/c2, the measured cross-section is σ(p$\\bar{p}$ → t$\\bar{t}$) = 8.3 ± 1.3(stat.) ± 0.7(syst.) ± 0.5(lumi.) pb. The result is consistent with the Standard Model prediction of 6.7$+0.7\\atop{-0.9}$ pb and represents a significant improvement in precision over previous results using this selection.

  15. Selective activation of heterologously expressed G protein-gated K+ channels by M2 muscarinic receptors in rat sympathetic neurones

    Science.gov (United States)

    Fernandez-Fernandez, Jose M; Wanaverbecq, Nicolas; Halley, Pam; Caulfield, Malcolm P; Brown, David A

    1999-01-01

    G protein-regulated inward rectifier K+ (GIRK) channels were over-expressed in dissociated rat superior cervical sympathetic (SCG) neurones by co-transfecting green fluorescent protein (GFP)-, GIRK1- and GIRK2-expressing plasmids using the biolistic technique. Membrane currents were subsequently recorded with whole-cell patch electrodes.Co-transfected cells had larger Ba2+-sensitive inwardly rectifying currents and 13 mV more negative resting potentials (in 3 mm[K+]o) than non-transfected cells, or cells transfected with GIRK1 or GIRK2 alone.Carbachol (CCh, 1–30 μm) increased the inwardly rectifying current in 70% of GIRK1+ GIRK2-transfected cells by 261 ± 53% (n = 6, CCh 30 μm) at −120 mV, but had no effect in non-transfected cells or in cells transfected with GIRK1 or GIRK2 alone. Pertussis toxin prevented the effect of carbachol but had no effect on basal currents.The effect of CCh was antagonized by 6 nm tripitramine but not by 100 nm pirenzepine, consistent with activation of endogenous M2 muscarinic acetylcholine receptors.In contrast, inhibition of the voltage-activated Ca2+ current by CCh was antagonized by 100 nm pirenzepine but not by 6 nm tripitramine, indicating that it was mediated by M4 muscarinic acetylcholine receptors.We conclude that endogenous M2 and M4 muscarinic receptors selectively couple to GIRK currents and Ca2+ currents respectively, with negligible cross-talk. PMID:10066893

  16. The power of allele frequency comparisons to detect the footprint of selection in natural and experimental situations

    Directory of Open Access Journals (Sweden)

    De Kovel Carolien

    2005-12-01

    Full Text Available Abstract Recently, inter-population comparisons of allele frequencies to detect past selection haven gained popularity. Data from genome-wide scans are used to detect the number and position of genes that have responded to unknown selection pressures in natural populations, or known selection pressures in experimental lines. Yet, the limitations and possibilities of these methods have not been well studied. In this paper, the objectives were (1 to investigate the distance over which a signal of directional selection is detectable under various scenarios, and (2 to study the power of the method depending on the properties of the used markers, for both natural populations and experimental set-ups. A combination of recurrence equations and simulations was used. The results show that intermediate strength selection on new mutations can be detected with a marker spacing of about 0.5 cM in large natural populations, 200 to 400 generations after the divergence of subpopulations. In experimental situations, only strong selection will be detectable, while markers can be spaced a few cM apart. Adaptation from standing variation in the base population will be hard to detect, though some solutions are presented for experimental designs.

  17. Iterative Pilot-Layer Aided Channel Estimation with Emphasis on Interleave-Division Multiple Access Systems

    Directory of Open Access Journals (Sweden)

    Schoeneich Hendrik

    2006-01-01

    Full Text Available Channel estimation schemes suitable for interleave-division multiple access (IDMA systems are presented. Training and data are superimposed. Training-based and semiblind linear channel estimators are derived and their performance is discussed and compared. Monte Carlo simulation results are presented showing that the derived channel estimators in conjunction with a superimposed pilot sequence and chip-by-chip processing are able to track fast-fading frequency-selective channels. As opposed to conventional channel estimation techniques, the BER performance even improves with increasing Doppler spread for typical system parameters. An error performance close to the case of perfect channel knowledge can be achieved with high power efficiency.

  18. Semantic Wavelet-Induced Frequency-Tagging (SWIFT Periodically Activates Category Selective Areas While Steadily Activating Early Visual Areas.

    Directory of Open Access Journals (Sweden)

    Roger Koenig-Robert

    Full Text Available Primate visual systems process natural images in a hierarchical manner: at the early stage, neurons are tuned to local image features, while neurons in high-level areas are tuned to abstract object categories. Standard models of visual processing assume that the transition of tuning from image features to object categories emerges gradually along the visual hierarchy. Direct tests of such models remain difficult due to confounding alteration in low-level image properties when contrasting distinct object categories. When such contrast is performed in a classic functional localizer method, the desired activation in high-level visual areas is typically accompanied with activation in early visual areas. Here we used a novel image-modulation method called SWIFT (semantic wavelet-induced frequency-tagging, a variant of frequency-tagging techniques. Natural images modulated by SWIFT reveal object semantics periodically while keeping low-level properties constant. Using functional magnetic resonance imaging (fMRI, we indeed found that faces and scenes modulated with SWIFT periodically activated the prototypical category-selective areas while they elicited sustained and constant responses in early visual areas. SWIFT and the localizer were selective and specific to a similar extent in activating category-selective areas. Only SWIFT progressively activated the visual pathway from low- to high-level areas, consistent with predictions from standard hierarchical models. We confirmed these results with criterion-free methods, generalizing the validity of our approach and show that it is possible to dissociate neural activation in early and category-selective areas. Our results provide direct evidence for the hierarchical nature of the representation of visual objects along the visual stream and open up future applications of frequency-tagging methods in fMRI.

  19. Semantic Wavelet-Induced Frequency-Tagging (SWIFT) Periodically Activates Category Selective Areas While Steadily Activating Early Visual Areas.

    Science.gov (United States)

    Koenig-Robert, Roger; VanRullen, Rufin; Tsuchiya, Naotsugu

    2015-01-01

    Primate visual systems process natural images in a hierarchical manner: at the early stage, neurons are tuned to local image features, while neurons in high-level areas are tuned to abstract object categories. Standard models of visual processing assume that the transition of tuning from image features to object categories emerges gradually along the visual hierarchy. Direct tests of such models remain difficult due to confounding alteration in low-level image properties when contrasting distinct object categories. When such contrast is performed in a classic functional localizer method, the desired activation in high-level visual areas is typically accompanied with activation in early visual areas. Here we used a novel image-modulation method called SWIFT (semantic wavelet-induced frequency-tagging), a variant of frequency-tagging techniques. Natural images modulated by SWIFT reveal object semantics periodically while keeping low-level properties constant. Using functional magnetic resonance imaging (fMRI), we indeed found that faces and scenes modulated with SWIFT periodically activated the prototypical category-selective areas while they elicited sustained and constant responses in early visual areas. SWIFT and the localizer were selective and specific to a similar extent in activating category-selective areas. Only SWIFT progressively activated the visual pathway from low- to high-level areas, consistent with predictions from standard hierarchical models. We confirmed these results with criterion-free methods, generalizing the validity of our approach and show that it is possible to dissociate neural activation in early and category-selective areas. Our results provide direct evidence for the hierarchical nature of the representation of visual objects along the visual stream and open up future applications of frequency-tagging methods in fMRI.

  20. λ-Selection Strategy in C+L Band 1-Pbit/s (448 WDM/19-Core/128 Gbit/s/channel) Flex-Grid Space Division Multiplexed Transmission

    DEFF Research Database (Denmark)

    Asif, Rameez; Ye, Feihong; Morioka, Toshio

    2015-01-01

    In this paper, an inter-core crosstalk based wavelength selection scheme has been proposed for flex-grid superchannels in space division multiplexed transmission. The two λ-selection strategies are categorized as: (a) aligned wavelength super-channels (Aλ-SCs), where all super-channels are placed...

  1. Selectivity enhancement in photoacoustic gas analysis via phase-sensitive detection at high modulation frequency

    Science.gov (United States)

    Kosterev, Anatoliy (Inventor)

    2010-01-01

    A method for detecting a target fluid in a fluid sample comprising a first fluid and the target fluid using photoacoustic spectroscopy (PAS), comprises a) providing a light source configured to introduce an optical signal having at least one wavelength into the fluid sample; b) modulating the optical signal at a desired modulation frequency such that the optical signal generates an acoustic signal in the fluid sample; c) measuring the acoustic signal in a resonant acoustic detector; and d) using the phase of the acoustic signal to detect the presence of the target fluid.

  2. Relation between derived-band auditory brainstem response latencies and behavioral frequency selectivity

    DEFF Research Database (Denmark)

    Strelcyk, Olaf; Christoforidis, Dimitrios; Dau, Torsten

    2009-01-01

    for some of the HI listeners. The behavioral auditory-filter bandwidths accounted for the across-listener variability in the ABR latencies: Cochlear response time decreased with increasing filter bandwidth, consistent with linear-system theory. The results link cochlear response time and frequency...... response times. For the same listeners, auditory-filter bandwidths at 2 kHz were estimated using a behavioral notched-noise masking paradigm. Generally, shorter derived-band latencies were observed for the HI than for the NH listeners. Only at low click sensation levels, prolonged latencies were obtained...

  3. Frequency-dependent selection on female morphs driven by premating interactions with males

    NARCIS (Netherlands)

    Bots, Jessica; Iserbyt, Arne; Van Gossum, Hans; Hammers, Martijn; Sherratt, Thomas N.

    Species showing color polymorphisms-the presence of two or more genetically determined color morphs within a single population-are excellent systems for studying the selective forces driving the maintenance of genetic diversity. Despite a shortage of empirical evidence, it is often suggested that

  4. Frequency Response Analysis of Current Controllers for Selective Harmonic Compensation in Active Power Filters

    DEFF Research Database (Denmark)

    Lascu, C.; Asiminoaei, L.; Boldea, I.

    2009-01-01

    This paper compares four current control structures for selective harmonic compensation in active power filters. All controllers under scrutiny perform the harmonic compensation by using arrays of resonant controllers, one for the fundamental and one for each harmonic of interest, in order to ach...

  5. Persistent human cardiac Na+ currents in stably transfected mammalian cells: Robust expression and distinct open-channel selectivity among Class 1 antiarrhythmics.

    Science.gov (United States)

    Wang, Ging Kuo; Russell, Gabriella; Wang, Sho-Ya

    2013-01-01

    Miniature persistent late Na(+) currents in cardiomyocytes have been linked to arrhythmias and sudden death. The goals of this study are to establish a stable cell line expressing robust persistent cardiac Na(+) currents and to test Class 1 antiarrhythmic drugs for selective action against resting and open states. After transient transfection of an inactivation-deficient human cardiac Na(+) channel clone (hNav1.5-CW with L409C/A410W double mutations), transfected mammalian HEK293 cells were treated with 1 mg/ml G-418. Individual G-418-resistant colonies were isolated using glass cylinders. One colony with high expression of persistent Na(+) currents was subjected to a second colony selection. Cells from this colony remained stable in expressing robust peak Na(+) currents of 996 ± 173 pA/pF at +50 mV (n = 20). Persistent late Na(+) currents in these cells were clearly visible during a 4-second depolarizing pulse albeit decayed slowly. This slow decay is likely due to slow inactivation of Na(+) channels and could be largely eliminated by 5 μM batrachotoxin. Peak cardiac hNav1.5-CW Na(+) currents were blocked by tetrodotoxin with an IC(50) value of 2.27 ± 0.08 μM (n = 6). At clinic relevant concentrations, Class 1 antiarrhythmics are much more selective in blocking persistent late Na(+) currents than their peak counterparts, with a selectivity ratio ranging from 80.6 (flecainide) to 3 (disopyramide). We conclude that (1) Class 1 antiarrhythmics differ widely in their resting- vs. open-channel selectivity, and (2) stably transfected HEK293 cells expressing large persistent hNav1.5-CW Na(+) currents are suitable for studying as well as screening potent open-channel blockers.

  6. Selection of mother wavelets for the detection of the oscillation frequencies in power signals of nuclear reactors

    International Nuclear Information System (INIS)

    Amador G, R.; Castillo D, R.; Ortiz V, J.

    2007-01-01

    Diverse types of transitory events can lead to oscillations of power in nuclear reactors. In such events, the power monitors provide a signal that contains important characteristics of the transitory one, as the oscillation frequency, tendencies, changes and the instants or periods in those that important events are presented. This characteristics are detected by means of diverse analysis techniques, as Autoregressive methods, Fourier Transform, Fourier Transform in Short Time, Wavelets Transform, among others. Presently work is used the one Wavelets Continuous Transform because it allows to carry out studies of the stationary, quasi-stationary and transitory signals in the Time-scale and Time-scale-spectrum planes. Contrary to other similar works, this work describes a methodology for the selection of the scales and the Wavelet mother to be applied the one Wavelets Continuous Transform, with the objective of detecting to the dominant frequencies of the system. To prove the proposal a broadly well-known real signal of an event of power oscillations it has been used. The obtained results correspond to three families of Wavelets mothers that fulfilled the conditions of scales and central frequency of the proposal. The results show that the value of the certain frequency oscillation in this work is practically the same one reported in other studies with other techniques. (Author)

  7. Frequency-Selective Fat Suppression Radiofrequency Pulse Train to Remove Olefinic Fats.

    Science.gov (United States)

    Abe, Takayuki

    2013-01-01

    CHESS pulse can suppress the signal originating from aliphatic fat protons but cannot suppress the signal from olefinic fat protons, which is near the resonance frequency of water protons. Adipose tissue contains various fat species; aliphatic fat comprises about 90 % and olefinic fat about 10 % of adipose tissue. Thus, CHESS pulse cannot be used to suppress the signal from adipose tissue completely. The purpose of this study was to find a method to suppress the signal from adipose tissue completely. The Fatsat train pulse, created with an arbitrary flip angle and insensitive to B1 inhomogeneity, was used. Because B1 inhomogeneity is larger on higher field magnetic resonance imaging, the fat suppression radiofrequency pulse needs to be B1-insensitive. To investigate a percentage of olefinic fat in adipose tissues, the excitation frequency of the Fatsat train pulse was varied from -240 to +400 Hz and the images and fat-suppressed images were obtained. The presence of olefinic fat comprising about 10 % of abdominal adipose tissue was identified. The result agreed with some previous papers. Complete fat suppression could be achieved by partial (10 %) inversion of longitudinal aliphatic fat magnetization and by canceling out the two fat magnetizations. The flip angle was identified to about 95°. In conclusion, the cause that the signal from adipose tissues cannot be suppressed completely has been found. Improved images that signals from adipose tissues were suppressed completely have been demonstrated. This technique can also be applied to several pulse sequences.

  8. [Selectivity and sensitivity to blocking by hydrogen ions of batrachotoxin-modified sodium channels in nerve fiber membranes].

    Science.gov (United States)

    Mozhaeva, G N; Naumov, A P; Khodorov, B I

    1983-01-01

    Currents through normal and batrachotoxin-modified sodium channels in frog nerve were measured under voltage clamp conditions. Measured reversal potentials and the Goldman equation were used to calculate relative permeabilities. The permeability ratios were: PNa: PNH4: PK = 1: 0.47: 0.19. Hydrogen-to-sodium permeability ratio was estimated from reversal potential measurements in Na-free acid (pH 3.7-3.8) solutions. It was 528 +/- 46 for batrachotoxin-modified sodium channels. Modified channels were less sensitive to hydrogen block as compared with normal ones. The difference in apparent pKa for acid group between normal and modified channels was about 0.40.

  9. Application of site and haplotype-frequency based approaches for detecting selection signatures in cattle

    Directory of Open Access Journals (Sweden)

    Moore Stephen

    2011-06-01

    Full Text Available Abstract Background 'Selection signatures' delimit regions of the genome that are, or have been, functionally important and have therefore been under either natural or artificial selection. In this study, two different and complementary methods--integrated Haplotype Homozygosity Score (|iHS| and population differentiation index (FST--were applied to identify traces of decades of intensive artificial selection for traits of economic importance in modern cattle. Results We scanned the genome of a diverse set of dairy and beef breeds from Germany, Canada and Australia genotyped with a 50 K SNP panel. Across breeds, a total of 109 extreme |iHS| values exceeded the empirical threshold level of 5% with 19, 27, 9, 10 and 17 outliers in Holstein, Brown Swiss, Australian Angus, Hereford and Simmental, respectively. Annotating the regions harboring clustered |iHS| signals revealed a panel of interesting candidate genes like SPATA17, MGAT1, PGRMC2 and ACTC1, COL23A1, MATN2, respectively, in the context of reproduction and muscle formation. In a further step, a new Bayesian FST-based approach was applied with a set of geographically separated populations including Holstein, Brown Swiss, Simmental, North American Angus and Piedmontese for detecting differentiated loci. In total, 127 regions exceeding the 2.5 per cent threshold of the empirical posterior distribution were identified as extremely differentiated. In a substantial number (56 out of 127 cases the extreme FST values were found to be positioned in poor gene content regions which deviated significantly (p ST values were found in regions of some relevant genes such as SMCP and FGF1. Conclusions Overall, 236 regions putatively subject to recent positive selection in the cattle genome were detected. Both |iHS| and FST suggested selection in the vicinity of the Sialic acid binding Ig-like lectin 5 gene on BTA18. This region was recently reported to be a major QTL with strong effects on productive life

  10. An ultrathin wide-band planar metamaterial absorber based on a fractal frequency selective surface and resistive film

    International Nuclear Information System (INIS)

    Fan Yue-Nong; Cheng Yong-Zhi; Nie Yan; Wang Xian; Gong Rong-Zhou

    2013-01-01

    We propose an ultrathin wide-band metamaterial absorber (MA) based on a Minkowski (MIK) fractal frequency selective surface and resistive film. This absorber consists of a periodic arrangement of dielectric substrates sandwiched with an MIK fractal loop structure electric resonator and a resistive film. The finite element method is used to simulate and analyze the absorption of the MA. Compared with the MA-backed copper film, the designed MA-backed resistive film exhibits an absorption of 90% at a frequency region of 2 GHz–20 GHz. The power loss density distribution of the MA is further illustrated to explain the mechanism of the proposed MA. Simulated absorptions at different incidence cases indicate that this absorber is polarization-insensitive and wide-angled. Finally, further simulated results indicate that the surface resistance of the resistive film and the dielectric constant of the substrate can affect the absorbing property of the MA. This absorber may be used in many military fields

  11. Hyper-spectral frequency selection for the classification of vegetation diseases

    OpenAIRE

    Dijkstra, Klaas; van de Loosdrecht, Jaap; Schomaker, Lambert; Wiering, Marco

    2017-01-01

    Reducing the use of pesticides by early visual detection of diseases in precision agriculture is important. Because of the color similarity between potato-plant diseases, narrow band hyper-spectral imaging is required. Payload constraints on unmanned aerial vehicles require reduc- tion of spectral bands. Therefore, we present a methodology for per-patch classification combined with hyper-spectral band selection. In controlled experiments performed on a set of individual leaves, we measure the...

  12. Pipe leak diagnostic using high frequency piezoelectric pressure sensor and automatic selection of intrinsic mode function

    Science.gov (United States)

    Yusop, Hanafi M.; Ghazali, M. F.; Yusof, M. F. M.; Remli, M. A. Pi; Kamarulzaman, M. H.

    2017-10-01

    In a recent study, the analysis of pressure transient signals could be seen as an accurate and low-cost method for leak and feature detection in water distribution systems. Transient phenomena occurs due to sudden changes in the fluid’s propagation in pipelines system caused by rapid pressure and flow fluctuation due to events such as closing and opening valves rapidly or through pump failure. In this paper, the feasibility of the Hilbert-Huang transform (HHT) method/technique in analysing the pressure transient signals in presented and discussed. HHT is a way to decompose a signal into intrinsic mode functions (IMF). However, the advantage of HHT is its difficulty in selecting the suitable IMF for the next data postprocessing method which is Hilbert Transform (HT). This paper reveals that utilizing the application of an integrated kurtosis-based algorithm for a z-filter technique (I-Kaz) to kurtosis ratio (I-Kaz-Kurtosis) allows/contributes to/leads to automatic selection of the IMF that should be used. This technique is demonstrated on a 57.90-meter medium high-density polyethylene (MDPE) pipe installed with a single artificial leak. The analysis results using the I-Kaz-kurtosis ratio revealed/confirmed that the method can be used as an automatic selection of the IMF although the noise level ratio of the signal is low. Therefore, the I-Kaz-kurtosis ratio method is recommended as a means to implement an automatic selection technique of the IMF for HHT analysis.

  13. Feature selection for neural network based defect classification of ceramic components using high frequency ultrasound.

    Science.gov (United States)

    Kesharaju, Manasa; Nagarajah, Romesh

    2015-09-01

    The motivation for this research stems from a need for providing a non-destructive testing method capable of detecting and locating any defects and microstructural variations within armour ceramic components before issuing them to the soldiers who rely on them for their survival. The development of an automated ultrasonic inspection based classification system would make possible the checking of each ceramic component and immediately alert the operator about the presence of defects. Generally, in many classification problems a choice of features or dimensionality reduction is significant and simultaneously very difficult, as a substantial computational effort is required to evaluate possible feature subsets. In this research, a combination of artificial neural networks and genetic algorithms are used to optimize the feature subset used in classification of various defects in reaction-sintered silicon carbide ceramic components. Initially wavelet based feature extraction is implemented from the region of interest. An Artificial Neural Network classifier is employed to evaluate the performance of these features. Genetic Algorithm based feature selection is performed. Principal Component Analysis is a popular technique used for feature selection and is compared with the genetic algorithm based technique in terms of classification accuracy and selection of optimal number of features. The experimental results confirm that features identified by Principal Component Analysis lead to improved performance in terms of classification percentage with 96% than Genetic algorithm with 94%. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Transmissive infrared frequency selective surfaces and infrared antennas: final report for LDRD 105749

    International Nuclear Information System (INIS)

    Wendt, Joel Robert; Hadley, G. Ronald; Samora, Sally; Loui, Hung; Cruz-Cabrera, Alvaro Augusto; Davids, Paul; Kemme, Shanalyn A.; Basilio, Lorena I.; Johnson, William Arthur; Peters, David William

    2009-01-01

    Plasmonic structures open up new opportunities in photonic devices, sometimes offering an alternate method to perform a function and sometimes offering capabilities not possible with standard optics. In this LDRD we successfully demonstrated metal coatings on optical surfaces that do not adversely affect the transmission of those surfaces at the design frequency. This technology could be applied as an RF noise blocking layer across an optical aperture or as a method to apply an electric field to an active electro-optic device without affecting optical performance. We also demonstrated thin optical absorbers using similar patterned surfaces. These infrared optical antennas show promise as a method to improve performance in mercury cadmium telluride detectors. Furthermore, these structures could be coupled with other components to lead to direct rectification of infrared radiation. This possibility leads to a new method for infrared detection and energy harvesting of infrared radiation.

  15. Arene guest selectivity and pore flexibility in a metal-organic framework with semi-fluorinated channel walls

    Science.gov (United States)

    Smith, Rebecca; Vitórica-Yrezábal, Iñigo J.; Hill, Adrian; Brammer, Lee

    2017-01-01

    A metal-organic framework (MOF) with one-dimensional channels of approximately hexagonal cross-section [Ag2(O2CCF2CF2CO2)(TMP)] 1 (TMP =2,3,5,6-tetramethylpyrazine) has been synthesized with MeOH filling the channels in its as-synthesized form as [Ag2(O2CCF2CF2CO2)(TMP)]·n(MeOH) 1-MeOH (n = 1.625 by X-ray crystallography). The two types of ligand connect columns of Ag(I) centres in an alternating manner, both around the channels and along their length, leading to an alternating arrangement of hydrocarbon (C-H) and fluorocarbon (C-F) groups lining the channel walls, with the former groups projecting further into the channel than the latter. MeOH solvent in the channels can be exchanged for a variety of arene guests, ranging from xylenes to tetrafluorobenzene, as confirmed by gas chromatography, 1H nuclear magnetic resonance (NMR) spectroscopy, thermogravimetric analysis and 13C cross-polarization magic angle spinning NMR spectroscopy. Alkane and perfluoroalkane guests, however, do not enter the channels. Although exhibiting some stability under a nitrogen atmosphere, sufficient to enable crystal structure determination, the evacuated MOF 1 is unstable for periods of more than minutes under ambient conditions or upon heating, whereupon it undergoes an irreversible solid-state transformation to a non-porous polymorph 2, which comprises Ag2(O2CCF2CF2CO2) coordination layers that are pillared by TMP ligands. This transformation has been followed in situ by powder X-ray diffraction and shown to proceed via a crystalline intermediate. This article is part of the themed issue 'Coordination polymers and metal-organic frameworks: materials by design'.

  16. Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells.

    Directory of Open Access Journals (Sweden)

    Chandan Goswami

    non-selective cation channels and cytoskeleton at multiple levels. These cross talks may help us to understand the molecular basis of the Taxol-induced neuropathic pain development commonly observed in cancer patients.

  17. No effects of power line frequency extremely low frequency electromagnetic field exposure on selected neurobehavior tests of workers inspecting transformers and distribution line stations versus controls.

    Science.gov (United States)

    Li, Li; Xiong, De-fu; Liu, Jia-wen; Li, Zi-xin; Zeng, Guang-cheng; Li, Hua-liang

    2014-03-01

    We aimed to evaluate the interference of 50 Hz extremely low frequency electromagnetic field (ELF-EMF) occupational exposure on the neurobehavior tests of workers performing tour-inspection close to transformers and distribution power lines. Occupational short-term "spot" measurements were carried out. 310 inspection workers and 300 logistics staff were selected as exposure and control. The neurobehavior tests were performed through computer-based neurobehavior evaluation system, including mental arithmetic, curve coincide, simple visual reaction time, visual retention, auditory digit span and pursuit aiming. In 500 kV areas electric field intensity at 71.98% of total measured 590 spots were above 5 kV/m (national occupational standard), while in 220 kV areas electric field intensity at 15.69% of total 701 spots were above 5 kV/m. Magnetic field flux density at all the spots was below 1,000 μT (ICNIRP occupational standard). The neurobehavior score changes showed no statistical significance. Results of neurobehavior tests among different age, seniority groups showed no significant changes. Neurobehavior changes caused by daily repeated ELF-EMF exposure were not observed in the current study.

  18. In vivo and in vitro attenuation of naloxone-precipitated experimental opioid withdrawal syndrome by insulin and selective KATP channel modulator.

    Science.gov (United States)

    Singh, Prabhat; Sharma, Bhupesh; Gupta, Surbhi; Sharma, B M

    2015-01-01

    Opiate exposure for longer duration develops state of dependence in humans and animals, which is revealed by signs and symptoms of withdrawal precipitated by opioid receptor antagonists. The sudden withdrawal of opioids produces a withdrawal syndrome in opioid-dependent subjects. Insulin and ATP-sensitive potassium (KATP) channel-mediated glucose homeostasis have been shown to modulate morphine withdrawal. Present study has been structured to investigate the role of insulin and pharmacological modulator of KATP channel (gliclazide) in experimental morphine withdrawal syndrome, both invivo and invitro. In this study, naloxone-precipitated morphine withdrawal syndrome in mice (invivo) as well as in rat ileum (invitro) were utilized to assess opioid withdrawal phenomenon. Morphine withdrawal syndromes like jumping and rearing frequency, forepaw licking, circling, fore paw tremor, wet dog shake, sneezing, overall morphine withdrawal severity (OMWS), serum glucose, brain malondialdehyde (MDA), glutathione (GSH), nitrite/nitrate, and calcium (Ca(+2)) were assessed. Naloxone has significantly increased morphine withdrawal syndrome, both invivo and invitro. Insulin and gliclazide have significantly attenuated, naloxone induced behavioral changes like jumping and rearing frequency, forepaw licking, wet dog shake, sneezing, straightening, circling, OMWS, and various biochemical impairments such as serum glucose, brain MDA, GSH, nitrite/nitrate, and Ca(+2) in morphine-dependent animals (invivo). In vitro, insulin and gliclazide have significantly reduced naloxone-induced contraction in morphine-withdrawn rat ileum preparation. Insulin and gliclazide (KATP channel blocker) have attenuated naloxone-precipitated morphine withdrawal syndrome, both invivo and invitro. Thus, insulin and KATP channel modulation may provide new avenues for research in morphine withdrawal.

  19. Photonic integrated circuit implementation of a sub-GHz-selectivity frequency comb filter for optical clock multiplication.

    Science.gov (United States)

    Geng, Zihan; Xie, Yiwei; Zhuang, Leimeng; Burla, Maurizio; Hoekman, Marcel; Roeloffzen, Chris G H; Lowery, Arthur J

    2017-10-30

    We report a photonic integrated circuit implementation of an optical clock multiplier, or equivalently an optical frequency comb filter. The circuit comprises a novel topology of a ring-resonator-assisted asymmetrical Mach-Zehnder interferometer in a Sagnac loop, providing a reconfigurable comb filter with sub-GHz selectivity and low complexity. A proof-of-concept device is fabricated in a high-index-contrast stoichiometric silicon nitride (Si 3 N 4 /SiO 2 ) waveguide, featuring low loss, small size, and large bandwidth. In the experiment, we show a very narrow passband for filters of this kind, i.e. a -3-dB bandwidth of 0.6 GHz and a -20-dB passband of 1.2 GHz at a frequency interval of 12.5 GHz. As an application example, this particular filter shape enables successful demonstrations of five-fold repetition rate multiplication of optical clock signals, i.e. from 2.5 Gpulses/s to 12.5 Gpulses/s and from 10 Gpulses/s to 50 Gpulses/s. This work addresses comb spectrum processing on an integrated platform, pointing towards a device-compact solution for optical clock multipliers (frequency comb filters) which have diverse applications ranging from photonic-based RF spectrum scanners and photonic radars to GHz-granularity WDM switches and LIDARs.

  20. A multi-channel device for high-density target-selective stimulation and long-term monitoring of cells and subcellular features in C. elegans

    Science.gov (United States)

    Coakley, Sean; Mugno, Paula; Hammarlund, Marc; Hilliard, Massimo A.; Lu, Hang

    2014-01-01

    Selective cell ablation can be used to identify neuronal functions in multicellular model organisms such as Caenorhabditis elegans. The optogenetic tool KillerRed facilitates selective ablation by enabling light-activated damage of cell or subcellular components in a temporally and spatially precise manner. However, the use of KillerRed requires stimulating (5 min-1 hr), culturing (~24 hrs) and imaging (often repeatedly) a large number of individual animals. Current manual manipulation methods are limited by their time-consuming, labor-intensive nature, and their usage of anesthetics. To facilitate large-scale selective ablation, culturing, and repetitive imaging, we developed a densely-packed multi-channel device and used it to perform high-throughput neuronal ablation on KillerRed-expressing animals. The ability to load worms in identical locations with high loading efficiency allows us to ablate selected neurons in multiple worms simultaneously. Our device also enables continuous observation of aminals for 24 hrs following KillerRed activation, and allows the animals to be recovered for behavioural assays. We expect this multi-channel device to facilitate a broad range of long-term imaging and selective illumination experiments in neuroscience. PMID:25257026

  1. Cancer-related channel selection: an extension for a sample of women who have had a mammogram.

    Science.gov (United States)

    Johnson, J D; Meischke, H

    1993-01-01

    This study examines the impact of three major classes of factors, triggers, impediments, and demographics, on the use of four different communication channels: doctors, friends/family, organizations, and media. A sample of women over forty (n = 209) who had a mammography were asked which channels they had turned to within the last year for cancer-related information. The most important variable in the significant discriminant functions was the degree of interpersonal influence within one's social network. These results are discussed in terms of their theoretic and pragmatic implications for the development of communication campaigns related to mammography screening.

  2. Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3

    OpenAIRE

    Wright, Paul D.; Veale, Emma L.; McCoull, David; Tickle, David C.; Large, Jonathan M.; Ococks, Emma; Gothard, Gemma; Kettleborough, Catherine; Mathie, Alistair; Jerman, Jeffrey

    2017-01-01

    Two-pore domain potassium channels (K2Ps) are characterized by their four transmembrane domain and two-pore topology. They carry background (or leak) potassium current in a variety of cell types. Despite a number of important roles there is currently a lack of pharmacological tools with which to further probe K2P function. We have developed a cell-based thallium flux assay, using baculovirus delivered TASK3 (TWIK-related acid-sensitive K+ channel 3, KCNK9, K2P9.1) with the aim of identifying ...

  3. Impact of online channel use on customer revenues and costs to serve : Considering product portfolios and self-selection

    NARCIS (Netherlands)

    Gensler, S.; Leeflang, P.S.H.; Skiera, B.

    Developing a strategy for online channels requires knowledge of the effects of customers' online use on their revenue and cost to serve, which ultimately influence customer profitability. The authors theoretically discuss and empirically examine these effects. An empirical study of retail banking

  4. Channelling and channelling radiation

    International Nuclear Information System (INIS)

    Soerensen, A.H.; Uggerhoej, E.

    1987-01-01

    The study of channelling phenomena has developed rapidly since the early 1960s and today channelling has found many applications. The radiation emitted by channelled megaelectronvolt and gigaelectronvolt electrons and positrons has been investigated extensively and the possibility of, for example, constructing intense tunable X- and γ-ray sources is being explored. Multi-gigaelectronvolt radiation and pair-creation processes in single crystals show similarities with strong-field effects and are of particular interest because of high production rates that persist far beyond the channelling regime. (author)

  5. Synthetic ciguatoxins selectively activate Nav1.8-derived chimeric sodium channels expressed in HEK293 cells.

    Science.gov (United States)

    Yamaoka, Kaoru; Inoue, Masayuki; Miyazaki, Keisuke; Hirama, Masahiro; Kondo, Chie; Kinoshita, Eiji; Miyoshi, Hiroshi; Seyama, Issei

    2009-03-20

    The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara, H., Miyazaki, K., and Hirama, M. (2004) Br. J. Pharmacol. 142, 879-889). In this study, we further explored the effects of CTX3C on the TTX-resistant sodium channel Na(v)1.8. TTX-resistant channels have been shown to be involved in transducing pain and related sensations (Akopian, A. N., Sivilotti, L., and Wood, J. N. (1996) Nature 379, 257-262). Thus, we hypothesized that ciguatoxin-induced activation of the Na(v)1.8 current would account for the neurological symptoms of ciguatera poisoning. We found that 0.1 mum CTX3C preferentially affected the activation process of the Na(v)1.8 channel compared with those of the Na(v)1.2 and Na(v)1.4 channels. Importantly, without stimulation, 0.1 mum CTX3C induced a large leakage current (I (L)). The conductance of the I (L) calculated relative to the maximum conductance (G (max)) was 10 times larger than that of Na(v)1.2 or Na(v)1.4. To determine the molecular domain of Na(v)1.8 responsible for conferring higher sensitivity to CTX3C, we made two chimeric constructs from Na(v)1.4 and Na(v)1.8. Chimeras containing the N-terminal half of Na(v)1.8 exhibited a large response similar to wild-type Na(v)1.8, indicating that the region conferring high sensitivity to ciguatoxin action is located in the D1 or D2 domains.

  6. Synthetic Ciguatoxins Selectively Activate Nav1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells*

    Science.gov (United States)

    Yamaoka, Kaoru; Inoue, Masayuki; Miyazaki, Keisuke; Hirama, Masahiro; Kondo, Chie; Kinoshita, Eiji; Miyoshi, Hiroshi; Seyama, Issei

    2009-01-01

    The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Nav1.2, Nav1.4, and Nav1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara, H., Miyazaki, K., and Hirama, M. (2004) Br. J. Pharmacol. 142, 879–889). In this study, we further explored the effects of CTX3C on the TTX-resistant sodium channel Nav1.8. TTX-resistant channels have been shown to be involved in transducing pain and related sensations (Akopian, A. N., Sivilotti, L., and Wood, J. N. (1996) Nature 379, 257–262). Thus, we hypothesized that ciguatoxin-induced activation of the Nav1.8 current would account for the neurological symptoms of ciguatera poisoning. We found that 0.1 μm CTX3C preferentially affected the activation process of the Nav1.8 channel compared with those of the Nav1.2 and Nav1.4 channels. Importantly, without stimulation, 0.1 μm CTX3C induced a large leakage current (IL). The conductance of the IL calculated relative to the maximum conductance (Gmax) was 10 times larger than that of Nav1.2 or Nav1.4. To determine the molecular domain of Nav1.8 responsible for conferring higher sensitivity to CTX3C, we made two chimeric constructs from Nav1.4 and Nav1.8. Chimeras containing the N-terminal half of Nav1.8 exhibited a large response similar to wild-type Nav1.8, indicating that the region conferring high sensitivity to ciguatoxin action is located in the D1 or D2 domains. PMID:19164297

  7. A Single Amino Acid Substitution in the Third Transmembrane Region Has Opposite Impacts on the Selectivity of the Parasiticides Fluralaner and Ivermectin for Ligand-Gated Chloride Channels.

    Science.gov (United States)

    Nakata, Yunosuke; Fuse, Toshinori; Yamato, Kohei; Asahi, Miho; Nakahira, Kunimitsu; Ozoe, Fumiyo; Ozoe, Yoshihisa

    2017-11-01

    Fluralaner (Bravecto) is a recently marketed isoxazoline ectoparasiticide. This compound potently inhibits GABA-gated chloride channels (GABACls) and less potently glutamate-gated chloride channels (GluCls) in insects. The mechanism underlying this selectivity is unknown. Therefore, we sought to identify the amino acid residues causing the low potency of fluralaner toward GluCls. We examined the fluralaner sensitivity of mutant housefly ( Musca domestica ) GluCls in which amino acid residues in the transmembrane subunit interface were replaced with the positionally equivalent amino acids of Musca GABACls. Of these amino acids, substitution of an amino acid (Leu315) in the third transmembrane region (TM3) with an aromatic amino acid dramatically enhanced the potency of fluralaner in the GluCls. In stark contrast to the enhancement of fluralaner potency, this mutation eliminated the activation of currents and the potentiation but not the antagonism of glutamate responses that are otherwise all elicited by the macrolide parasiticide ivermectin (IVM). Our findings indicate that the amino acid Leu315 in Musca GluCls plays significant roles in determining the selectivity of fluralaner and IVM for these channels. Given the high sequence similarity of TM3, this may hold true more widely for the GluCls and GABACls of other insect species. Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics.

  8. Channel estimation for physical layer network coding systems

    CERN Document Server

    Gao, Feifei; Wang, Gongpu

    2014-01-01

    This SpringerBrief presents channel estimation strategies for the physical later network coding (PLNC) systems. Along with a review of PLNC architectures, this brief examines new challenges brought by the special structure of bi-directional two-hop transmissions that are different from the traditional point-to-point systems and unidirectional relay systems. The authors discuss the channel estimation strategies over typical fading scenarios, including frequency flat fading, frequency selective fading and time selective fading, as well as future research directions. Chapters explore the performa

  9. A 31 GHz Survey of Low-Frequency Selected Radio Sources

    Science.gov (United States)

    Mason, B. S.; Weintraub, L.; Sievers, J.; Bond, J. R.; Myers, S. T.; Pearson, T. J.; Readhead, A. C. S.; Shepherd, M. C.

    2009-10-01

    The 100 m Robert C. Byrd Green Bank Telescope and the 40 m Owens Valley Radio Observatory telescope have been used to conduct a 31 GHz survey of 3165 known extragalactic radio sources over 143 deg2 of the sky. Target sources were selected from the NRAO VLA Sky Survey in fields observed by the Cosmic Background Imager (CBI); most are extragalactic active galactic nuclei (AGNs) with 1.4 GHz flux densities of 3-10 mJy. The resulting 31 GHz catalogs are presented in full online. Using a maximum-likelihood analysis to obtain an unbiased estimate of the distribution of the 1.4-31 GHz spectral indices of these sources, we find a mean 31-1.4 GHz flux ratio of 0.110 ± 0.003 corresponding to a spectral index of α = -0.71 ± 0.01 (S ν vprop να) 9.0% ± 0.8% of sources have α > - 0.5 and 1.2% ± 0.2% have α > 0. By combining this spectral-index distribution with 1.4 GHz source counts, we predict 31 GHz source counts in the range 1 mJy S 31) = (16.7 ± 1.7) deg-2(S 31/1 mJy)-0.80±0.07. We also assess the contribution of mJy-level (S 1.4 GHz < 3.4 mJy) radio sources to the 31 GHz cosmic microwave background power spectrum, finding a mean power of ell(ell + 1)C src ell/(2π) = 44 ± 14 μK2 and a 95% upper limit of 80 μK2 at ell = 2500. Including an estimated contribution of 12 μK2 from the population of sources responsible for the turn-up in counts below S 1.4 GHz = 1 mJy, this amounts to 21% ± 7% of what is needed to explain the CBI high-ell excess signal, 275 ± 63 μK2. These results are consistent with other measurements of the 31 GHz point-source foreground.

  10. Human versus Computer Controlled Selection of Ventilator Settings: An Evaluation of Adaptive Support Ventilation and Mid-Frequency Ventilation

    Directory of Open Access Journals (Sweden)

    Eduardo Mireles-Cabodevila

    2012-01-01

    Full Text Available Background. There are modes of mechanical ventilation that can select ventilator settings with computer controlled algorithms (targeting schemes. Two examples are adaptive support ventilation (ASV and mid-frequency ventilation (MFV. We studied how different clinician-chosen ventilator settings are from these computer algorithms under different scenarios. Methods. A survey of critical care clinicians provided reference ventilator settings for a 70 kg paralyzed patient in five clinical/physiological scenarios. The survey-derived values for minute ventilation and minute alveolar ventilation were used as goals for ASV and MFV, respectively. A lung simulator programmed with each scenario’s respiratory system characteristics was ventilated using the clinician, ASV, and MFV settings. Results. Tidal volumes ranged from 6.1 to 8.3 mL/kg for the clinician, 6.7 to 11.9 mL/kg for ASV, and 3.5 to 9.9 mL/kg for MFV. Inspiratory pressures were lower for ASV and MFV. Clinician-selected tidal volumes were similar to the ASV settings for all scenarios except for asthma, in which the tidal volumes were larger for ASV and MFV. MFV delivered the same alveolar minute ventilation with higher end expiratory and lower end inspiratory volumes. Conclusions. There are differences and similarities among initial ventilator settings selected by humans and computers for various clinical scenarios. The ventilation outcomes are the result of the lung physiological characteristics and their interaction with the targeting scheme.

  11. Increased fire frequency promotes stronger spatial genetic structure and natural selection at regional and local scales in Pinus halepensis Mill.

    Science.gov (United States)

    Budde, Katharina B; González-Martínez, Santiago C; Navascués, Miguel; Burgarella, Concetta; Mosca, Elena; Lorenzo, Zaida; Zabal-Aguirre, Mario; Vendramin, Giovanni G; Verdú, Miguel; Pausas, Juli G; Heuertz, Myriam

    2017-04-01

    The recurrence of wildfires is predicted to increase due to global climate change, resulting in severe impacts on biodiversity and ecosystem functioning. Recurrent fires can drive plant adaptation and reduce genetic diversity; however, the underlying population genetic processes have not been studied in detail. In this study, the neutral and adaptive evolutionary effects of contrasting fire regimes were examined in the keystone tree species Pinus halepensis Mill. (Aleppo pine), a fire-adapted conifer. The genetic diversity, demographic history and spatial genetic structure were assessed at local (within-population) and regional scales for populations exposed to different crown fire frequencies. Eight natural P. halepensis stands were sampled in the east of the Iberian Peninsula, five of them in a region exposed to frequent crown fires (HiFi) and three of them in an adjacent region with a low frequency of crown fires (LoFi). Samples were genotyped at nine neutral simple sequence repeats (SSRs) and at 251 single nucleotide polymorphisms (SNPs) from coding regions, some of them potentially important for fire adaptation. Fire regime had no effects on genetic diversity or demographic history. Three high-differentiation outlier SNPs were identified between HiFi and LoFi stands, suggesting fire-related selection at the regional scale. At the local scale, fine-scale spatial genetic structure (SGS) was overall weak as expected for a wind-pollinated and wind-dispersed tree species. HiFi stands displayed a stronger SGS than LoFi stands at SNPs, which probably reflected the simultaneous post-fire recruitment of co-dispersed related seeds. SNPs with exceptionally strong SGS, a proxy for microenvironmental selection, were only reliably identified under the HiFi regime. An increasing fire frequency as predicted due to global change can promote increased SGS with stronger family structures and alter natural selection in P. halepensis and in plants with similar life history traits

  12. Improvement of Microwave Absorbance of Polymer Composites of W-Type Hexaferrite Powders by Attachment of Frequency Selective Surface

    Directory of Open Access Journals (Sweden)

    Cho H.-S.

    2017-06-01

    Full Text Available This work investigates the effect of a frequency selective surface (FSS composed of a regular array of square loop elements on the absorption properties of grounded ferrite composites. Polymer matrix composites of CoZnW hexaferrite powders having small magnetic loss were used as the substrate material. Computational tools were used to model the interaction between electromagnetic waves and materials and determine the reflection coefficient. Reflection loss and bandwidth were greatly improved by attaching an FSS with controlled electrical resistance (R onto the grounded ferrite composites. For the FSS with R = 800 Ω, the minimum reflection loss decreased to −25 dB at 10 GHz and the bandwidth was broadened to 7.5-12.5 GHz with respect to −10 dB reflection loss.

  13. Methods for estimating selected low-flow frequency statistics and harmonic mean flows for streams in Iowa

    Science.gov (United States)

    Eash, David A.; Barnes, Kimberlee K.

    2017-01-01

    A statewide study was conducted to develop regression equations for estimating six selected low-flow frequency statistics and harmonic mean flows for ungaged stream sites in Iowa. The estimation equations developed for the six low-flow frequency statistics include: the annual 1-, 7-, and 30-day mean low flows for a recurrence interval of 10 years, the annual 30-day mean low flow for a recurrence interval of 5 years, and the seasonal (October 1 through December 31) 1- and 7-day mean low flows for a recurrence interval of 10 years. Estimation equations also were developed for the harmonic-mean-flow statistic. Estimates of these seven selected statistics are provided for 208 U.S. Geological Survey continuous-record streamgages using data through September 30, 2006. The study area comprises streamgages located within Iowa and 50 miles beyond the State's borders. Because trend analyses indicated statistically significant positive trends when considering the entire period of record for the majority of the streamgages, the longest, most recent period of record without a significant trend was determined for each streamgage for use in the study. The median number of years of record used to compute each of these seven selected statistics was 35. Geographic information system software was used to measure 54 selected basin characteristics for each streamgage. Following the removal of two streamgages from the initial data set, data collected for 206 streamgages were compiled to investigate three approaches for regionalization of the seven selected statistics. Regionalization, a process using statistical regression analysis, provides a relation for efficiently transferring information from a group of streamgages in a region to ungaged sites in the region. The three regionalization approaches tested included statewide, regional, and region-of-influence regressions. For the regional regression, the study area was divided into three low-flow regions on the basis of hydrologic

  14. β-adrenergic Receptor Blocker ICI 118,551 Selectively Increases Intermediate-Conductance Calcium-Activated Potassium Channel (IKCa)-Mediated Relaxations in Rat Main Mesenteric Artery.

    Science.gov (United States)

    Ozkan, Melike Hacer; Uma, Serdar

    2017-12-26

    Endothelial IK C a and/or SK C a channels play an important role in the control of vascular tone by participating in endothelium-dependent relaxation. Whether β-AR antagonists, mainly used in hypertension, affect endothelial K C a channel function is unknown. In this study, we examined the effect of the β2-AR antagonist and inverse agonist ICI 118,551 on the IK C a /SK C a channel activity by assessing functional relaxation responses to several agonists that stimulate these channels. Mesenteric arterial rings isolated from male Sprague Dawley mounted to organ baths. Acetylcholine elicited IK C a - and SK C a -mediated relaxations that were abolished by TRAM-34 and apamin, respectively. ICI 118,551, which did not dilate the arteries per se, increased the IK C a -mediated relaxations, whereas SK C a -mediated relaxations remained unaltered. Same potentiating effect was also detected on the IK C a -mediated relaxations to carbachol and A23187, but not to NS309. Neither acetylcholine-induced nitric oxide-mediated relaxations nor SNP relaxations changed with ICI 118,551. The PKA inhibitor KT-5720, the selective β2-AR agonist salbutamol, the selective β2-AR antagonist butoxamine, the non-selective β-AR antagonist propranolol, and the inverse agonists carvedilol or nadolol failed to affect the IK C a -mediated relaxations. ICI 118,551-induced increase was not reversed by salbutamol or propranolol as well. Besides, low potassium-induced relaxations in endothelium-removed arteries remained the same in the presence of ICI 118,551. These data demonstrate a previously unrecognized action of ICI 118,551, the ability to potentiate endothelial IK C a channel-mediated vasodilation, through a mechanism independent of β2-AR antagonistic or inverse agonistic action. Instead, the enhancement of acetylcholine relaxation seems likely to occur by a mechanism secondary to endothelial calcium increase. © 2017 Nordic Association for the Publication of BCPT (former Nordic

  15. Evaluation of the Relative Validity of the Short Diet Questionnaire for Assessing Usual Consumption Frequencies of Selected Nutrients and Foods

    Directory of Open Access Journals (Sweden)

    Bryna Shatenstein

    2015-08-01

    Full Text Available A 36-item Short Diet Questionnaire (SDQ was developed to assess usual consumption frequencies of foods providing fats, fibre, calcium, vitamin D, in addition to fruits and vegetables. It was pretested among 30 community-dwelling participants from the Québec Longitudinal Study on Nutrition and Successful Aging, “NuAge” (n = 1793, 52.4% women, recruited in three age groups (70 ± 2 years; 75 ± 2 years; 80 ± 2 years. Following revision, the SDQ was administered to 527 NuAge participants (55% female, distributed among the three age groups, both sexes and languages (French, English prior to the second of three non-consecutive 24 h diet recalls (24HR and validated relative to the mean of three 24HR. Full data were available for 396 participants. Most SDQ nutrients and fruit and vegetable servings were lower than 24HR estimates (p < 0.05 except calcium, vitamin D, and saturated and trans fats. Spearman correlations between the SDQ and 24HR were modest and significant (p < 0.01, ranging from 0.19 (cholesterol to 0.45 (fruits and vegetables. Cross-classification into quartiles showed 33% of items were jointly classified into identical quartiles of the distribution, 73% into identical and contiguous quartiles, and only 7% were frankly misclassified. The SDQ is a reasonably accurate, rapid approach for ranking usual frequencies of selected nutrients and foods. Further testing is needed in a broader age range.

  16. Highly Localized Acoustic Streaming and Size-Selective Submicrometer Particle Concentration Using High Frequency Microscale Focused Acoustic Fields.

    Science.gov (United States)

    Collins, David J; Ma, Zhichao; Ai, Ye

    2016-05-17

    Concentration and separation of particles and biological specimens are fundamental functions of micro/nanofluidic systems. Acoustic streaming is an effective and biocompatible way to create rapid microscale fluid motion and induce particle capture, though the >100 MHz frequencies required to directly generate acoustic body forces on the microscale have traditionally been difficult to generate and localize in a way that is amenable to efficient generation of streaming. Moreover, acoustic, hydrodynamic, and electrical forces as typically applied have difficulty manipulating specimens in the submicrometer regime. In this work, we introduce highly focused traveling surface acoustic waves (SAW) at high frequencies between 193 and 636 MHz for efficient and highly localized production of acoustic streaming vortices on microfluidic length scales. Concentration occurs via a novel mechanism, whereby the combined acoustic radiation and streaming field results in size-selective aggregation in fluid streamlines in the vicinity of a high-amplitude acoustic beam, as opposed to previous acoustic radiation induced particle concentration where objects typically migrate toward minimum pressure locations. Though the acoustic streaming is induced by a traveling wave, we are able to manipulate particles an order of magnitude smaller than possible using the traveling wave force alone. We experimentally and theoretically examine the range of particle sizes that can be captured in fluid streamlines using this technique, with rapid particle concentration demonstrated down to 300 nm diameters. We also demonstrate that locations of trapping and concentration are size-dependent, which is attributed to the combined effects of the acoustic streaming and acoustic forces.

  17. Mathematical Model and Computational Analysis of Selected Transient States of Cylindrical Linear Induction Motor Fed via Frequency Converter

    Directory of Open Access Journals (Sweden)

    Andrzej Rusek

    2008-01-01

    Full Text Available The mathematical model of cylindrical linear induction motor (C-LIM fed via frequency converter is presented in the paper. The model was developed in order to analyze numerically the transient states. Problems concerning dynamics of ac-machines especially linear induction motor are presented in [1 – 7]. Development of C-LIM mathematical model is based on circuit method and analogy to rotary induction motor. The analogy between both: (a stator and rotor windings of rotary induction motor and (b winding of primary part of C-LIM (inductor and closed current circuits in external secondary part of C-LIM (race is taken into consideration. The equations of C-LIM mathematical model are presented as matrix together with equations expressing each vector separately. A computational analysis of selected transient states of C-LIM fed via frequency converter is presented in the paper. Two typical examples of C-LIM operation are considered for the analysis: (a starting the motor at various static loads and various synchronous velocities and (b reverse of the motor at the same operation conditions. Results of simulation are presented as transient responses including transient electromagnetic force, transient linear velocity and transient phase current.

  18. Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice

    DEFF Research Database (Denmark)

    Jacobsen, J P R; Redrobe, J P; Hansen, H H

    2009-01-01

    performed equally well in passive avoidance, object recognition and the Morris water maze. Thus, some aspects of working/short-term memory are disrupted in T/T mice. Using in situ hybridization, we further found the cognitive deficits in T/T mice to be paralleled by reduced brain-derived neurotrophic factor......Small-conductance calcium-activated K(+) channels 1-3 (SK1-3) are important for neuronal firing regulation and are considered putative CNS drug targets. For instance non-selective SK blockers improve performance in animal models of cognition. The SK subtype(s) involved herein awaits identification...... and the question is difficult to address pharmacologically due to the lack of subtype-selective SK-channel modulators. In this study, we used doxycycline-induced conditional SK3-deficient (T/T) mice to address the cognitive consequences of selective SK3 deficiency. In T/T mice SK3 protein is near-eliminated from...

  19. Moessbauer effect: on the application of digital synthesis in order tosynchronize the frequency of the function generator of the transducer with the frequency of the channel opening commands, in 'multiscale' operation

    International Nuclear Information System (INIS)

    Carrilho, R.J.; Marins, J.E.R.

    1981-01-01

    A new instrument for the channel opening command, synchronized to the movement, is designed, developed and produced, together with a new and complete amplifier for the transducer activation. (L.C.) [pt

  20. Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.

    Science.gov (United States)

    Findeisen, Felix; Campiglio, Marta; Jo, Hyunil; Abderemane-Ali, Fayal; Rumpf, Christine H; Pope, Lianne; Rossen, Nathan D; Flucher, Bernhard E; DeGrado, William F; Minor, Daniel L

    2017-06-21

    For many voltage-gated ion channels (VGICs), creation of a properly functioning ion channel requires the formation of specific protein-protein interactions between the transmembrane pore-forming subunits and cystoplasmic accessory subunits. Despite the importance of such protein-protein interactions in VGIC function and assembly, their potential as sites for VGIC modulator development has been largely overlooked. Here, we develop meta-xylyl (m-xylyl) stapled peptides that target a prototypic VGIC high affinity protein-protein interaction, the interaction between the voltage-gated calcium channel (Ca V ) pore-forming subunit α-interaction domain (AID) and cytoplasmic β-subunit (Ca V β). We show using circular dichroism spectroscopy, X-ray crystallography, and isothermal titration calorimetry that the m-xylyl staples enhance AID helix formation are structurally compatible with native-like AID:Ca V β interactions and reduce the entropic penalty associated with AID binding to Ca V β. Importantly, electrophysiological studies reveal that stapled AID peptides act as effective inhibitors of the Ca V α 1 :Ca V β interaction that modulate Ca V function in an Ca V β isoform-selective manner. Together, our studies provide a proof-of-concept demonstration of the use of protein-protein interaction inhibitors to control VGIC function and point to strategies for improved AID-based Ca V modulator design.