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Sample records for frank kreith ronald

  1. Anne Frank and After

    NARCIS (Netherlands)

    Galen Last, van Dick; Wolfswinkel, Rolf

    1996-01-01

    Between 1940 and 1945, 110,000 of the 140,000 Dutch Jews were deported to the death camps in Eastern Europe. 80% never returned. In Anne Frank and After the authors focus on two main questions: how exactly did this happen, and how has Dutch literature come to terms with this appalling event? In the

  2. Entrevista com Joseph Frank

    Directory of Open Access Journals (Sweden)

    Giuliana Teixeira de Almeida

    2014-09-01

    Full Text Available Uma das últimas entrevistas com Joseph Frank, autor da monumental biografia de Dosotiévski (4vols, EdUNESP, falecido em 2013. Giuliana Teixeira de Almeida nasceu em 5 de novembro de 1986 na cidade de São Paulo. Cursou bacharelado e licenciatura em história na Universidade de São Paulo. Iniciou sua atividade acadêmica com uma pesquisa na área de história social sobre Cinema Novo e Ditadura na Imprensa Alternativa (jornal Opinião, sob orientação de Marcos Napolitano. Por causa da paixão pela literatura russa, mudou o foco da pesquisa acadêmica e ingressou no mestrado no departamento de Letras Orientais, no Programa de Literatura e Cultura Russa. Sob orientação de Bruno Gomide, defendeu em 2013 a dissertação de mestrado intitulada Pelo Prisma Biográfico: Joseph Frank e Dostoiévski. A pesquisa foi financiada pela FAPESP, mesma agencia que viabilizou financeiramente um estágio de pesquisa de seis meses na Universidade de Berkeley, na Califórnia, sob orientação de Irina Paperno. Durante este estágio de pesquisa conseguiu entrevistar Joseph Frank em outubro de 2012. 

  3. Obituary: Ronald A. Parise, 1951-2008

    Science.gov (United States)

    Gull, Theodore R.

    2009-01-01

    Ronald A. Parise, astronomer and astronaut, passed away at his home in Burtonsville, Maryland, in the presence of his family on 9 May 2008. He died of a brain tumor at age 56 after several years of valiant struggle. He was an inspiration to many students, ham operators, astronomers, and friends the world over. His enthusiasm for astronomy and space exploration was infectious. We, colleagues at Goddard Space Flight Center and Computer Sciences Corporation, treasured his contributions to space astronomy and human spaceflight. Ron, along with Samuel Durrance, flew as Payload Specialist on Astro-1 and Astro-2. They were selected by peers from the instrument teams of the Hopkins Ultraviolet Telescope (HUT provided by Hopkins University), the Ultraviolet Imaging Telescope (UIT, Goddard Space Flight Center) and the Wisconsin Ultraviolet Photo-Polarimetry Experiment (WUPPE, University of Wisconsin). Astro-1 flew 2-10 December 1990 on the Columbia. Astro-2 flew 2-18 March 1995. Ron carried along amateur radio equipment and operated on the air during his free time during the missions. Ron was born 24 May 1951 in Warren, Ohio, to Henry and Catherine Parise. His interests first were in amateur radio, becoming a licensed operator by age eleven. He later was attracted to both astronomy and aviation, becoming a pilot in his teens. Ron graduated from Western Reserve High School in 1969 and attended Youngstown State University where he received a bachelor of science degree in physics with minors in mathematics, astronomy. and geology. His graduate work was at University of Florida where he obtained a masters degree in 1977 and a doctorate in 1979 in astronomy. Ron joined Operations Research, Inc. upon graduation, working at Goddard Space Flight Center where he supported studies of several NASA missions. In 1980 he joined Computer Sciences Corporation supporting the International Ultraviolet Explorer [IUE], first as a data-management scientist and later as the section manager of the

  4. Frank Middelburg (1936-1985)

    Science.gov (United States)

    Ardeberg, A.

    1985-12-01

    La noticia de la desaparicion de Frank Middelburg, en el dia 15 de Noviembre de 1985, conmovio a tode el mundo astronomico con un sentimiento especial de tristeza. Frank no solo era un experto reconocido en el campo de procesamiento de imagen y un ingeniero de sistemas altamente respetado, tambien era un preciado amigo y colega.

  5. Philipp Frank, Richard von Mises, and the Frank-Mises

    Science.gov (United States)

    Siegmund-Schultze, Reinhard

    2007-01-01

    The theoretical physicist Philipp Frank (1884 1966) and the applied mathematician Richard von Mises (1883 1953) both received their university education in Vienna shortly after 1900 and became friends at the latest during the Great War.They were attached to the Vienna Circle of Logical Positivists and wrote an influential two-part work on the differential and integral equations of mechanics and physics, the Frank-Mises, of 1925 and 1927, with its second edition following in 1930 and 1935.This work originated in the lectures that the mathematician Bernhard Riemann (1826 1866) delivered on partial differential equations and their applications to physical questions at the University of Göttingen between 1854 and 1862, which were edited and published posthumously in1869 by the physicist Karl Hattendorff (1834 1882).The immediate precursor of the Frank-Mises, however, was the extensive revision of Hattendorff’s edition of Riemann’s lectures that the mathematician Heinrich Weber (1842 1913) published in two volumes, the Riemann-Weber, of 1900 and 1901, with its second edition following in 1910 and 1912. I trace this historical lineage, explore the nature and contents of the Frank-Mises, and discuss its complementary relationship to the first volume of the text that the mathematicians Richard Courant (1888 1972) and David Hilbert (1862 1943) published on the methods of mathematical physics in 1924, the Courant-Hilbert,which, when it and its second volume of 1937 were translated into English and extensively revised in 1953 and 1961, eclipsed the classic Frank-Mises.

  6. Frank Lloyd Wright for Kids.

    Science.gov (United States)

    Thorne-Thomsen, Kathleen

    In this instructional guide, architect Frank Lloyd Wright becomes the focus of interdisciplinary lessons intended for use with elementary level students. The text is organized in 2 sections. Section 1 provides an 8 chapter biography and study of Wright. The second section gives 21 lesson activities in foods, natural science, geometry, patterns,…

  7. The Case Study of Frank

    Science.gov (United States)

    Eynde, Peter Op't; Hannula, Markku S.

    2006-01-01

    As a unifying feature of this Special Issue, we have asked proponents of each framework to analyse an empirical classroom account of one student's process of solving a mathematical problem. Here, for the case study of "Frank", we give the main data that were available to all authors.

  8. Frank Blythe (1924-2010)

    CERN Multimedia

    2010-01-01

    Frank Blythe, one of the very first engineers engaged in the CERN adventure, passed away on October 22. Born and educated in Salford (England), after a time spent at Metropolitan-Vickers in Manchester, in January 1954 he joined the group at the Nuclear Physics Research Laboratory in Liverpool that was working on the first CERN accelerator, the Synchrocyclotron (SC). At that time CERN had not yet officially been constituted, yet had a well defined work programme, the design and construction work being carried out in various European laboratories. In Liverpool the work included the SC vacuum and cooling system, radiation shielding, experimental areas and beams. By the end of 1954, Frank reached the CERN premises in Geneva, and contributed significantly to the successful construction work of the Synchrocyclotron. He later became responsible for the drawing office and the mechanical workshop (Engineering Group) attached to the MSC Division, and also serving the NP/EP Division. He kept this position until ...

  9. NOAA Ship Ronald Brown Underway Meteorological Data, Quality Controlled

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship Ronald Brown Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and Oceanographic System...

  10. NOAA Ship Ronald Brown Underway Meteorological Data, Near Real Time

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship Ronald Brown Underway Meteorological Data (Near Real Time, updated daily) are from the Shipboard Automated Meteorological and Oceanographic System (SAMOS)...

  11. Frank Krienen (1917-2008)

    CERN Document Server

    2008-01-01

    Amsterdam, summer 1952: it was here that the first recruits for CERN ‘s 600 MeV Synchrocyclotron project met Frank Krienen for the first time. A young assistant to Prof. C.J. Bakker at the Physics Institute, he soon became the mastermind behind the most daring aspects of the project: the frequency modulating circuit, based on a vibrating tuning fork, was his creation. He was a respected and inspiring leader throughout the construction period of the accelerator and, at the same time, an older brother and an exacting mentor. Frank later devoted himself to developing particle detectors, in particular spark wire chambers using different types of readout. His next major involvement at CERN was his contribution to the glorious g-2 saga. Frank’s contributions to the last experiment of the anomalous magnetic moment of the muon (g-2) done at CERN (1969-1977) were very important in many aspects. The last (g-2) experiment was based on many...

  12. Obituary: Ronald Cecil Stone, 1946-2005

    Science.gov (United States)

    Monet, Alice Kay Babcock

    2006-12-01

    Ronald C. Stone, an astronomer at the US Naval Observatory Flagstaff Station, passed away on 10 September 2005 in Downer's Grove, IL, following a valiant struggle with cancer. He was fifty-nine years old. Ron was born on 9 June 1946 in Seattle, Washington, to Helen (Vocelka) and Cecil Stone. His father was a World War II veteran who attended college on the GI Bill and became a mechanical engineer. He and his wife raised three sons: Dwight, Ronald, and Gavin. They lived in a number of locations across the U.S. before settling at last in Downer's Grove when Ron was in the fourth grade. Ron's interest in astronomy began when he was given a toy planetarium projector while still in grade school, and later a small telescope. In high school, he also built his own telescope, grinding the 6-inch mirror by hand. He completed grade school and high school in Downer's Grove and did his undergraduate studies at the University of Illinois at Urbana-Champaign, majoring in astronomy and physics and graduating cum laude in 1968. The following year, he was drafted into the U.S. Army and served for two years, including a stint in Vietnam. Although his primary assignment was auditing, he was also involved in the defense of the Long Binh base in Vietnam. He was honorably discharged from the service in 1971 and enrolled that fall at the University of Chicago. While a graduate student working with Bill van Altena, Ron developed his life long interest in the field of astrometry. Van Altena recalls him as "a quiet and cheerful student who wanted to learn, and [who] worked hard to understand the intricacies of astrometry... deriving the most precise proper motions from the 40-inch [Yerkes] refractor plates." Working at Yerkes Observatory in Williams Bay, Wisconsin, he completed a thesis entitled, "Mean Secular Parallax at Low Galactic Latitude." While living in Wisconsin, Ron also became engaged to Ellen Mickel, and the two were married at his parents' home in Downer's Grove. After earning

  13. An Interview with Dean Howard Frank

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Howard Frank was appointed dean of the University of Maryland's Robert H. Smith School of Business in 1997. He is widely recognized as a world-class information technology expert whose accomplishments include fundamental contributions to the development of the Intemet. Frank is also a prolific author, having written over 190 articles and chapters in books on technology and the management of technology. CIB had an intensive interview with him in Shanghai recently.

  14. In Memoriam: Dr. Frank John Fenner

    Centers for Disease Control (CDC) Podcasts

    2011-04-22

    This podcast reflects on one of the greatest pioneers in virology, Dr. Frank John Fenner. Dr. Frederick Murphy, a member of EID's editorial board and the Institute of Medicine, and professor of Pathology at the University of Texas Medical Branch in Galveston, shares professional and personal stories of Dr. Frank Fenner.  Created: 4/22/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 4/26/2011.

  15. Ronald Reagan ja Eesti iseseisvus / Jüri Luik

    Index Scriptorium Estoniae

    Luik, Jüri, 1966-

    2004-01-01

    Eesti suursaadik USA-s kinnitab, et USA ekspresident Ronald Reagan äratas idablokis inimeste moraalse ja vaimse jõu, hävitas hirmu ning Eesti võlgneb talle huku äärelt pääsemise. Reagani revolutsioonilisest jõust nii sise- kui välispoliitikas, kommunismivastasusest ja NSVL-i vaimsest purustamisest

  16. Ronald Reagan ja Eesti iseseisvus / Jüri Luik

    Index Scriptorium Estoniae

    Luik, Jüri, 1966-

    2004-01-01

    Eesti suursaadik USA-s kinnitab, et USA ekspresident Ronald Reagan äratas idablokis inimeste moraalse ja vaimse jõu, hävitas hirmu ning Eesti võlgneb talle huku äärelt pääsemise. Reagani revolutsioonilisest jõust nii sise- kui välispoliitikas, kommunismivastasusest ja NSVL-i vaimsest purustamisest

  17. Het laatste avondmaal: Ronald Dworkin (1931-2013)

    NARCIS (Netherlands)

    Maris, C.

    2013-01-01

    Op 14 februari 2013 overleed Ronald Dworkin, de invloedrijkste rechtsfilosoof van de afgelopen decennia. Cees Maris schrijft in deze bijdrage over de opvattingen van Dworkin, het Juiste Antwoord, morele waarheid, zijn publicaties en deelname aan publieke discussies, maar ook over de kritiek die Dwor

  18. Hypothetical Markets: Educational Application of Ronald Dworkin's "Sovereign Virtue"

    Science.gov (United States)

    Gough, Stephen

    2006-01-01

    The purpose of this paper is to consider, in principle and at the most general level, a particular possible approach to educational policy-making. This approach involves an education-specific application of the notion of hypothetical markets first developed in Ronald Dworkin's book "Sovereign Virtue: The theory and practice of equality" (2000).…

  19. 76 FR 66072 - Albert Ronald Cioffi: Debarment Order

    Science.gov (United States)

    2011-10-25

    ... HUMAN SERVICES Food and Drug Administration Albert Ronald Cioffi: Debarment Order AGENCY: Food and Drug... the Federal Food, Drug, and Cosmetic Act (the FD&C Act) debarring Albert Cioffi, MD for 5 years from... to him (Staff Manual Guide 1410.35), finds that Albert R. Cioffi has been convicted of a...

  20. Obituary: Ronald Eugene Pitts, 1949-2008

    Science.gov (United States)

    MacConnell, D. Jack

    2009-01-01

    Ronald Pitts, systems engineer in the Commanding Branch of the Space Telescope Science Institute and long-time Computer Sciences Corporation employee, died suddenly of a stroke on 4 May 2008 at his home in Laurel, Maryland. He was a dedicated scientist-engineer, husband, father, volunteer, and cherished friend to many. Ron was born on 19 January 1949 in Tucson, Arizona, and was raised, along with his sister Suzanne, on his parents' turkey farm outside Tucson. He picked up practical knowledge from his father, Vernon, and became a competent amateur electrician and plumber, skills he kept honed and used throughout his life. His mother, Ruth (Stephens), was a nurse and taught him compassion and patience and encouraged his inquisitive mind. Ron attended public schools and enrolled at the University of Arizona, graduating with a B. S. in Astronomy in 1971. Being from a family of modest means, he put himself through school working summers and part-time at a large copper mine south of town. Ron enrolled in the graduate astronomy program at the Ohio State University [OSU] in the fall of 1971 where he was a first-year fellowship student. During his second and third years, he was the Perkins Assistant, taking spectra for the very exacting but appreciative Philip Keenan who once remarked to another faculty member that Ron was the best observer he ever had. Later, in 1980, Ron was co-author with Keenan on "Revised MK Spectral Types for G, K, and M stars" and again in 1985 in a study of supergiants in open clusters. He met his future wife, Patricia Moore, also a graduate student in the department, and they were wed in 1973. Ron was also partially supported during his early OSU years by an NSF grant to Robert Wing, writing parts of Wing's photometric reduction code and observing on the program at Kitt Peak and Flagstaff in the summer of 1974. Wing remembers him as being very competent and pleasant to work with. Ron's thesis topic was "Oscillator Strengths for Neutral Iron and

  1. Obituary: Ronald N. Bracewell, 1921-2007

    Science.gov (United States)

    Petrosian, Vahé

    2009-01-01

    Ronald N. Bracewell, Professor Emeritus (since 1991) of Electrical Engineering at Stanford University, and a true renaissance man of science, died of a heart attack on 12 August 2007 at his home. Ron Bracewell was born in Sydney, Australia, on 22 July 1921, one of the two sons of Cecil and Valerie Bracewell. He graduated from the University of Sydney in 1941 and received his doctorate degree in physics from Cambridge University in 1949. During World War II, Ron worked in the Australian National Radar Establishment, where he designed and developed microwave radar equipment. Like several other World War II radar scientists, after the war he used this experience to pioneer the new field of radio astronomy. With J. L. Pawsey, in 1955 he published the first comprehensive textbook in this field entitled, Radio Astronomy. Bracewell joined the Stanford Electrical Engineering faculty in 1955, and from 1974 on he held the first prestigious Lewis Terman professorship. He was awarded the Outstanding Service Award of the department in 1984. In 1988, he was named an officer of the Order of Australia--the Australian equivalent of Order of the British Empire. Soon after his arrival at Stanford, Bracewell designed and began building a solar spectroheliograph, consisting of thirty-two dish antennas in the form of a cross. This was completed in 1961 and provided daily maps of the Sun for more than a decade encompassing more than one solar activity cycle of eleven years. These maps were useful in predicting magnetic storms caused by solar activity and were used by NASA during the first landing on the Moon. In 1971 he started the building of a five-element radio interferometer, for observation of extragalactic radio sources, with the novel design of unequal spacing that gave the resolution of a ten-element array. Both telescopes are now dismantled. The common characteristics of these and other projects were that they were all built in-house with a limited budget, often a small fraction

  2. Obituary: Frank Culver Jones, 1932-2007

    Science.gov (United States)

    Ormes, Johnathan F.; Streitmatter, Robert E.

    2007-12-01

    Frank C. Jones, an emeritus theoretical physicist at NASA, died May 2, 2007 at age 74 after a struggle with a rare form of cancer. He died at his home in Silver Spring, Maryland, surrounded by his family. Frank was born July 30, 1932 in Fort Worth, Texas, the oldest of three boys. His parents were Kenneth Hugh and Nancy Culver Jones. Frank's father was a lawyer, and his grandfather was a Methodist minister. Frank graduated from Rice University in 1954 and earned a master's degree in 1955 and a doctorate in 1961, both in physics, from the University of Chicago. He did his graduate work with Prof. John Simpson. Dr. Jones began his professional career as an instructor in physics at Princeton University before joining NASA's Goddard Space Flight Center in 1963 as a National Research Council associate. He subsequently became a member of the Theory Division and the Laboratory for High Energy Astrophysics. His area of expertise was the origin, transport, and electromagnetic interactions of cosmic rays. His particular focus was the stochastic physics related to the diffusion of particles in random fields, plasma turbulence, and the shock acceleration of charged particles in collisionless plasmas. From 1993 to 1995, Frank was head of Goddard's Theoretical High Energy Astrophysics Office and continued to serve as Head of the Theory group. In 2003 he served as Acting Chief of the Laboratory for High Energy Astrophysics. He retired in 2005 and continued his affiliation with NASA as an emeritus scientist at Goddard until his death. As a youngster, Frank showed the signs of curiosity and initiative that indicated he might become an experimentalist. At the memorial service for Frank, his brother related the stories of how Frank had rigged a hidden microphone to play through the family television as his brother courted a young woman on the front porch swing, and how one of Frank's early chemistry experiments caused all the family silverware to turn black. Although Frank started

  3. Obituary: Frank K. Edmondson (1912-2008)

    Science.gov (United States)

    Pilachowski, Catherine A.; Olson, Margaret K. Edmondson; Edmondson, Frank K., Jr.

    2009-12-01

    Hanging in the basement of Kirkwood Observatory on the Indiana University campus is a battered sign, dated Aug 31, 1932, announcing "Indiana Univ. Eclipse Station." While the path of totality passed well north of Bloomington, IN, where only 80% of the Sun's disk was covered, the eclipse made a lasting impression on the young Frank Kelley Edmondson, then an undergraduate student at Indiana University. Frank was born on August 1, 1912, in Milwaukee, Wisconsin, to Clarence Edward Edmondson and Marie (Kelley) Edmondson. Growing up in Seymour, Indiana, he became interested in astronomy at an early age, reading voraciously from the "Book of Knowledge" at an aunt's house (The Book of Knowledge Set of Encyclopedias). He learned magic and was acquainted with Blackstone, the magician. He took ballet lessons and performed with his brother. He was a YMCA Camp Counselor at Camp Bedford where he taught natural sciences to the campers. He worked one summer as a cook on an ore boat on Lake Michigan. In high school he sang in a musical - and wore a false beard. In 1944 he grew his own beard, one of only two on the IU faculty at the time, and he kept the beard all the many years since. In 1996, Frank was elected to the Shields High School "Wall of Fame." After graduating from Shields High School in 1929, Frank enrolled at Indiana University. He was a member of the IU intercollegiate debate team for four years. He was initiated into Phi Beta Kappa as a junior and was a member of Sigma Xi. He graduated in 1933 and earned a Master's degree in 1934 based on a thesis ("An Analysis of the Radial Velocities of Twenty-One Globular Star Clusters") and professional experience earned while holding the Lawrence Fellowship at the Lowell Observatory in Flagstaff, Arizona in 1934-35, where he worked as an observing assistant to Clyde Tombaugh. Despite his close association with Lowell, Tombaugh, and Pluto, Frank approved of the decision of the International Astronomical Union in 2006 to change

  4. The Frank Lloyd Wright Home and Studio.

    Science.gov (United States)

    Donahue, Kimberly; Gabor, Sharon

    1989-01-01

    This lesson plan introduces seventh-ninth graders to Frank Lloyd Wright and shows how nature influenced and inspired the design of his home and studio. Students will: identify natural design elements from the house, apply their awareness of form to their own natural and built environment, and create designs based on natural forms they find…

  5. Frank Netter's Legacy: Interprofessional Anatomy Instruction

    Science.gov (United States)

    Niekrash, Christine E.; Copes, Lynn E.; Gonzalez, Richard A.

    2015-01-01

    Several medical schools have recently described new innovations in interprofessional interactions in gross anatomy courses. The Frank H. Netter MD School of Medicine at Quinnipiac University in Hamden, CT has developed and implemented two contrasting interprofessional experiences in first-year medical student gross anatomy dissection laboratories:…

  6. Frank Netter's Legacy: Interprofessional Anatomy Instruction

    Science.gov (United States)

    Niekrash, Christine E.; Copes, Lynn E.; Gonzalez, Richard A.

    2015-01-01

    Several medical schools have recently described new innovations in interprofessional interactions in gross anatomy courses. The Frank H. Netter MD School of Medicine at Quinnipiac University in Hamden, CT has developed and implemented two contrasting interprofessional experiences in first-year medical student gross anatomy dissection laboratories:…

  7. Obituary: Frank J. Low (1933-2009)

    Science.gov (United States)

    McCarthy, Don

    2011-12-01

    Frank James Low was born on November 23, 1933, in Mobile, Alabama. He received his undergraduate degree in physics from Yale University in 1955, and his Ph.D. in physics from Rice University in 1959. He worked at Texas Instruments, NRAO, Rice University, and spent most of his career at The University of Arizona with Steward Observatory and the Lunar and Planetary Laboratory. To honor his fundamental insight and innovations that revolutionized the fields of infrared and airborne astronomy, Frank received the Helen B. Warner Prize (1968), the Joseph Weber Award (2003), shared the Rumford Prize in physics (1986), the Karl Jansky Lectureship (2006), and the Bruce Medal (2006) for lifetime contributions in astronomy. This year the world celebrates the International Year of Astronomy, commemorating the accomplishments of Galileo. There are great parallels between Frank and Galileo. After developing a revolutionary low-temperature detector, Frank re-engineered and optimized telescopes for infrared performance. He not only oriented them to the heavens but also placed them there throughout Earth's atmosphere and to the Moon. He made fantastic new discoveries from the Sun throughout the Universe. He radically changed the way the entire world looks at the Universe and impacted generations of new scientists as well as the general public. Frank's level of innovation is stunning and diverse. Chopping and undersized secondary mirrors, cold baffling, cryogenic designs, "Low Dewars," Helium-3 systems, JFET amplifiers for the IRAS satellite, airborne astronomy, the silver-coated 28-inch survey telescope, the MMT, the 36-foot radio dish, Apollo 17 radiometer, television detector systems, infrared microscopes, and on and on. His insights enabled the IRAS and Spitzer missions and contributed to Spacelab2, KAO, SOFIA, NICMOS/HST, JWST, etc. He also established a small business (Infrared Laboratories Inc.) that for more than 40 years has supplied instrumentation to astronomers and semi

  8. Healthcare Pioneers: Pehin Dato Philip I. Franks.

    Directory of Open Access Journals (Sweden)

    2011-06-01

    Full Text Available Pehin Dato Philip I. Franks graduated from St Bartholomew’s Hospital Medical School, London in 1930. After working for four years in London, he joined the Indian Medical Service in 1934 where he worked until 1947. He later worked in Malaya as an eye specialist before coming to Brunei on 6th September 1961 as Brunei’s first eye specialist (State Ophthalmologist.

  9. World System History: Arrighi, Frank, and the Way Forward

    Directory of Open Access Journals (Sweden)

    Robert A. Denemark

    2015-08-01

    Full Text Available Giovanni Arrighi dedicated Adam Smith in Beijing to the memory of Andre Gunder Frank. In this review I have been asked to consider the elements of Arrighi’s volume that Frank would have liked, and those he would have disliked. I identify five elements of world system history, which Frank worked to build during the last 20 years of his career, and assess areas of consonance and contradiction with Arrighi’s volume.

  10. The Early Retirement of Gen Ronald R. Fogleman, Chief of Staff, United States Air Force

    Science.gov (United States)

    2001-01-01

    The Early Retirement of Gen Ronald R. Fogleman, Chief of Staff, United States Air Force *EDITED by DR. RICHARD H. KOHN Editorial Abstract: Air...Force chief of staff Gen Ronald Fogleman’s early retirement in 1997 has caused great speculation. Was this a “resignation in protest”? Here for the...COVERED 00-00-2001 to 00-00-2001 4. TITLE AND SUBTITLE The Early Retirement of Gen Ronald R. Fogleman, Chief of Staff, United States Air Force 5a

  11. Frank Capra and Elia Kazan, American outsiders

    Directory of Open Access Journals (Sweden)

    Yves Carlet

    2010-11-01

    Full Text Available Frank Capra and Elia Kazan both came to the United States as children. From immigrant stock, each experienced the effects of being looked down upon as outsiders to Anglo culture. Based on the two men’s autobiographical accounts, together with their films and biographical writings about them, this article examines the routes by which they sought entry into the dominant culture. This process would require the rejection, in each case, of part of his family heritage. It would lead to very different attitudes to ethnicity in their films: Kazan demonstrated interest in the subject, whereas Capra largely suppressed it. The article underlines other “covert dialogues” in the films directed by the two men. It shows that they most diverged over issues of sexuality and the later rediscovery of their ethnic roots.

  12. Frank-Starling曲线与容量管理%Frank-Starling curve and capacity management

    Institute of Scientific and Technical Information of China (English)

    杜微; 刘大为

    2015-01-01

    Frank-Starling定律是指静脉回心血量提供给心脏前负荷的多少决定心脏每搏输出量.影响曲线的因素包括心室前负荷、心肌收缩力、心室后负荷、体位因素、体温等.从生理学角度Frank-Starling曲线和静脉回流曲线相对位置决定患者有无容量反应性.在临床中,判断患者的容量状态是否在曲线的上升支的方法包括容量负荷试验、基于心肺相互关系理论衍生参数,和自体模拟输液等方法.容量管理的流程是基于Frank-Starling曲线内涵而衍生的容量复苏的"金三角",该方法使复苏效果最大化,同时最大程度减少容量过负荷导致的副反应.

  13. A Body in Motion: A Conversation with Frank Gresham

    Science.gov (United States)

    Zabel, Robert; Kaff, Marilyn; Teagarden, James

    2015-01-01

    Dr. Frank Gresham provides his reflections on a long and productive career in providing support to children with significant challenges. Dr. Gresham also provides his thoughts on the future of the field.

  14. 78 FR 29781 - Before Administrative Judges: Ronald M. Spritzer, Chairman, Dr. Anthony J. Baratta, Dr. Randall J...

    Science.gov (United States)

    2013-05-21

    ... COMMISSION Atomic Safety and Licensing Board Before Administrative Judges: Ronald M. Spritzer, Chairman, Dr... submitted to: Mail: Administrative Judge Ronald M. Spritzer, Atomic Safety and Licensing Board Panel, Mail... statement should be sent to the Chairman of this Licensing Board as follows: Mail: Administrative...

  15. NATO peab jääma oluliseks / Jamie Shea, Ronald Asmus ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Shea, Jamie

    2006-01-01

    NATO peasekretäri poliitikaplaneerimise juht dr. Jamie Shea ja USA Saksa Marshalli Keskuse direktor dr. Ronald Asmus räägivad NATO uuendamise tähtsusest ja selleteemalise avaliku debati vajalikkusest. NATO Riia tippkohtumise ülesandest, Eesti uutest väljakutsetest NATO-s

  16. Interview to Ronald Fernando Garcia Ruiz, lead scientist COLLAPS experiment, ISOLDE

    CERN Multimedia

    2016-01-01

    Interview to Ronald Fernando Garcia Ruiz, lead scientist COLLAPS experiment, ISOLDE, on the occasion of the publication on Nature of the high precision measurement by the COLLAPS collaboration of the shift in energy of the electrons sorrounding the Calcium 52 nucleus, depending on the neutron number of the Calcium isotopes.

  17. A View of War and Soldiering in the Carey Novels of Ronald Welch

    Science.gov (United States)

    Barnes, Clive

    2016-01-01

    Ronald Welch's novels featuring the military adventures of the young men of the Carey family were first published between 1954 and 1976 and have recently been reissued. They were uniquely representative of historical military adventure for children in the Britain of this period; and were the last example of a vigorous century-old genre in…

  18. NATO peab jääma oluliseks / Jamie Shea, Ronald Asmus ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Shea, Jamie

    2006-01-01

    NATO peasekretäri poliitikaplaneerimise juht dr. Jamie Shea ja USA Saksa Marshalli Keskuse direktor dr. Ronald Asmus räägivad NATO uuendamise tähtsusest ja selleteemalise avaliku debati vajalikkusest. NATO Riia tippkohtumise ülesandest, Eesti uutest väljakutsetest NATO-s

  19. A View of War and Soldiering in the Carey Novels of Ronald Welch

    Science.gov (United States)

    Barnes, Clive

    2016-01-01

    Ronald Welch's novels featuring the military adventures of the young men of the Carey family were first published between 1954 and 1976 and have recently been reissued. They were uniquely representative of historical military adventure for children in the Britain of this period; and were the last example of a vigorous century-old genre in…

  20. 质疑"质疑Frank-Starling心脏定律"

    Institute of Scientific and Technical Information of China (English)

    李晨; 唐红

    2009-01-01

    @@ 何川、何培芳撰写"质疑Frank-Starling心脏定律"一文,深入探讨了Frank-Starling定律的本质和局限性,有助于我们深入理解该定律,同时作者敢于质疑权威的精神十分值得大家学习.可惜的是该文没有能够设计和实施实验来支持自身论点.

  1. Frank Capra's "Why We Fight" Series and the American Audience.

    Science.gov (United States)

    German, Kathleen M.

    1990-01-01

    Argues that the United States government suppressed Frank Capra's 1944 documentary, "The Battle of China," because it lacked the visual framework of arguments evidenced by the other films in Capra's "Why We Fight" series. Investigates Capra's portrayal of fundamental American values through the visual contrast techniques of…

  2. Cardiac thin filament regulation and the Frank-Starling mechanism.

    Science.gov (United States)

    Kobirumaki-Shimozawa, Fuyu; Inoue, Takahiro; Shintani, Seine A; Oyama, Kotaro; Terui, Takako; Minamisawa, Susumu; Ishiwata, Shin'ichi; Fukuda, Norio

    2014-07-01

    The heart has an intrinsic ability to increase systolic force in response to a rise in ventricular filling (the Frank-Starling law of the heart). It is widely accepted that the length dependence of myocardial activation underlies the Frank-Starling law of the heart. Recent advances in muscle physiology have enabled the identification of the factors involved in length-dependent activation, viz., titin (connectin)-based interfilament lattice spacing reduction and thin filament "on-off" regulation, with the former triggering length-dependent activation and the latter determining the number of myosin molecules recruited to thin filaments. Patients with a failing heart have demonstrated reduced exercise tolerance at least in part via depression of the Frank-Starling mechanism. Recent studies revealed that various mutations occur in the thin filament regulatory proteins, such as troponin, in the ventricular muscle of failing hearts, which consequently alter the Frank-Starling mechanism. In this article, we review the molecular mechanisms of length-dependent activation, and the influence of troponin mutations on the phenomenon.

  3. 75 FR 77665 - Frank Russell Company, Administrative Service Center, Including On-Site Leased Workers From Volt...

    Science.gov (United States)

    2010-12-13

    ... Employment and Training Administration Frank Russell Company, Administrative Service Center, Including On... for Worker Adjustment Assistance on July 30, 2010, applicable to workers of Frank Russell Company..., Washington location of Frank Russell Company, Administrative Service Center. The Department has determined...

  4. Julgeolekuanalüütik : maailm on ohtlikum kui enne Iraagi sõda / Ronald D. Asmus ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Asmus, Ronald D., 1957-2011

    2005-01-01

    Saksa Marshalli Fondi tegevdirektor Ameerika ja Euroopa suhetest, Euroopa Liidu poliitikast Venemaa suhtes, Eesti panusest Euroopa Liidu poliitika kujundamisesse, NATO 2006. aasta tippkohtumisest ja Ukraina võimalikust liitumisest NATO-ga. Lisa: Dr Ronald D. Asmus

  5. Special Article: Ronald D. Miller: tribute to a past editor-in-chief.

    Science.gov (United States)

    Tuman, Kenneth J

    2012-12-01

    For anesthesiologists around the world who have practiced or trained in the past 4 decades, the name Ronald Miller, MD, has been synonymous with a commitment to excellence that has been evident in all aspects of his remarkable career as a distinguished clinician-scientist, editor, writer, and educator. Dr. Miller's contributions as Editor-in-Chief of Anesthesia & Analgesia (1991-2006) have stimulated this salutation of his career and of his influence on transforming the Journal.

  6. Contemporary artists from the circumpolar region. Aslaug Juliussen and Ronald W. Senungetuk

    OpenAIRE

    Gullickson, Charis Ann

    2006-01-01

    This thesis is a comparative study investigating contemporary circumpolar art, with main focus on the Norwegian artist Aslaug Juliussen and the Alaskan artist Ronald W. Senungetuk. Both artists are Indigenous people, yet neither of them has a preference of being identified as Indigenous artists. In analyzing six artworks, three by each artist, the ambivalent nature of the “Indigenous label” will be examined. This study will show that it is difficult, in terms of an art historical perspective,...

  7. Contemporary artists from the circumpolar region. Aslaug Juliussen and Ronald W. Senungetuk

    OpenAIRE

    Gullickson, Charis Ann

    2006-01-01

    This thesis is a comparative study investigating contemporary circumpolar art, with main focus on the Norwegian artist Aslaug Juliussen and the Alaskan artist Ronald W. Senungetuk. Both artists are Indigenous people, yet neither of them has a preference of being identified as Indigenous artists. In analyzing six artworks, three by each artist, the ambivalent nature of the “Indigenous label” will be examined. This study will show that it is difficult, in terms of an art historical perspective,...

  8. Use of the Frank sequence in pulsed EPR

    DEFF Research Database (Denmark)

    Tseitlin, Mark; Quine, Richard W.; Eaton, Sandra S.;

    2011-01-01

    The Frank polyphase sequence has been applied to pulsed EPR of triarylmethyl radicals at 256MHz (9.1mT magnetic field), using 256 phase pulses. In EPR, as in NMR, use of a Frank sequence of phase steps permits pulsed FID signal acquisition with very low power microwave/RF pulses (ca. 1.5m......W in the application reported here) relative to standard pulsed EPR. A 0.2mM aqueous solution of a triarylmethyl radical was studied using a 16mm diameter cross-loop resonator to isolate the EPR signal detection system from the incident pulses. Keyword: Correlation spectroscopy,Multi-pulse EPR,Low power pulses...

  9. Simulation of the Frank-Starling Law of the Heart

    OpenAIRE

    Samo Ribarič; Marjan Kordaš

    2012-01-01

    We developed a lumped parameter, computer-based model of an equivalent electronic circuit for a one-atrium one-ventricle (frog) heart attached to a vascular circuit, to simulate a basic concept of cardiovascular physiology, the Frank-Starling Law of the Heart. A series of simulations was performed, to observe changes in cardiovascular variables (e.g., arterial pressure, ventricular volume, and valve flows) if either preload or afterload was increased. The simulated data agreed qualitatively, ...

  10. A DIMENSÃO INTERPRETATIVA DO DIREITO COMO INTEGRIDADE A PARTIR DE RONALD DWORKIN / THE INTERPRETATIVE DIMENSION OF LAW AS INTEGRITY FROM RONALD DWORKIN

    Directory of Open Access Journals (Sweden)

    Vladimir Passos de Freitas

    2017-04-01

    Full Text Available The present essay intends to analyze the theory of interpretation proposed by Ronald Dworkin. In particular, the duty judges have to observe the coherence and integrity in interpreting the abstract provisions of the constitutional text, in order to verify the role that the Judiciary could legitimately exercise in a democratic regime. To do so, we will initially address the law as integrity and the metaphor of the novel chain. Subsequently, the paper emphasizes how judges interpret the abstract provisions of the Constitution, the so-called moral reading of the Constitution. Finally, inserted within the scope of the constitutional democracy proposed by the author, it will be analyzed the performance of the Judiciary having as a parameter the right as integrity. The method used to carry out the research was the deductive one, through a bibliographical revision of the works of the aforementioned author, as well as the reading of works elaborated by critics of the theory of Dworkin.

  11. CONSTITUTIONAL OBSERVATORY OF RONALD DWORKIN: RECONSTRUCTING THE HERMENEUTIC EXPERIENCE OF THE LAW

    OpenAIRE

    Montarroyos, Heraldo Elias; Universidade Federal do Pará, UFPA, Campus de Marabá, Faculdade de Direito

    2014-01-01

    DOI: http://dx.doi.org/10.12957/10.12957/rfd.2014.5637O objetivo deste breve estudo é investigaro modo como foram produzidos os argumentos jurídicos de dois acórdãos doTribunal Regional do Trabalho da 8ª Região, estado do Pará, utilizando com essafinalidade o programa de pesquisa hermenêutico de Ronald Dworkin baseado nateoria da integridade, através do qual identificamos a formação de umacomunidade judiciária de princípios e quatro características comportamentaisinterligadas na argumentação ...

  12. Frank-Condon factors for H2O(+) molecular bands

    Science.gov (United States)

    Shefov, N. N.

    1983-11-01

    The Frank-Condon factors q sub (v' v'') are calculated for the spectra of the H2O(+) molecule by the method of Volkenstein et al. (1972). The results are presented in a table for values of v' from 5 to 17 and of v'' from zero to 4, indicating which bands have been observed either in the laboratory or in comets. It is shown that the photon scattering coefficient of Chamberlain (1978) can be calculated using these data for the (8,0) band; values of about 0.060 for the earth and about 0.17 for Halley's comet (at its 1986 perihelion) are determined.

  13. The art of nursing. "Frank's story": student response.

    Science.gov (United States)

    Eydenberg, Kaitlyn

    2008-03-01

    The author of this article explores her definition of the art of nursing through a response to an interview by Dr. Kathryn Gramling with a patient named Frank. She determines that nursing, although it also requires technical skill and a strong knowledge base, becomes art when the practitioner adopts the caring skills of compassion, touching, and empathy. The poem Dr. Gramling wrote in response to her contact with Frank reinforces the definition created by the author. When some patients enter a hospital, they experience certain feelings, such as fear, uncertainty, and helplessness. They are placed in a strange setting and are not in the best of health, but each patient deals with sickness differently. Some may act frightened, while others may act impatient and uncooperative. Often, it is a nurse's duty to help ease a patient through this difficult transition. The way a nurse does this makes all the difference to a patient's stay at the hospital. A nurse's impact on the patient can affect the patient either positively or negatively. A nurse must go above and beyond the technical part of nursing in order to make nursing an art.

  14. Die vyfvoudig versterkte vertellersfunksie in die dagboeke van Anne Frank

    Directory of Open Access Journals (Sweden)

    C. Reinecke

    1996-05-01

    Full Text Available A five-fold strengthened narrative function in the diaries of Anne Frank In assuming that the total communication situation in the true diary has a character of its own, it is suggested that the narrative situation is studied, on the one hand, from the viewpoint of the autobiographical contract claiming a bond of identity between the real author, the I-narrator and the I-persona, and on the other hand from the poststructuralistic view asserting that these instances are not identical to one another and that the implicit author should be duly recognised. A close textual analysis of the narrative situation in the original diaries of Anne Frank leads to our identifying five instances strengthening the narrative function - the real author, the I-narrator, the I-persona, the implicit and the explicit author. While these instances can be distinguished from one another, the bond of identity between them is so tight that the textual construction is a testimony to reality. The five-fold narrative corpus functioning in the diaries persuasively conveys a message of truth. A remarkable characteristic of the narrative situation is the persistent explicitising of the implicit author, which can be seen as a concretisation of the intention of truth and sincerity posed by the autobiographical contract.

  15. DIGITAL DOCUMENTATION OF FRANK LLOYD WRIGHT’S MASTERPIECE, FALLINGWATER

    Directory of Open Access Journals (Sweden)

    P. Jerome

    2017-08-01

    Full Text Available Since 1988, the professional staff of Architectural Preservation Studio (APS has been involved with the conservation of Frank Lloyd Wright’s Fallingwater in Mill Run, PA. Designed and erected from 1935 to 1939 as a weekend home for the Kauffman family, the complex consists of the main house and guest house. After five years of reports and prototype repairs, we produced a two-volume master plan. Using original Frank Lloyd Wright drawings from Avery Library as background drawings, we measured every surface and reproduced the drawings in CAD, also developing elevations of every room. Stone-by-stone drawings of every flagstone floor and terrace scheduled to be lifted were also created using overlapping film photography that was assembled into a photo mosaic. By 2005, we designed, administered and completed a four-phase exterior restoration, with the paint-stripping and repainting of interior rooms being performed during the brief winter period when the building is closed to the public on an ongoing basis. In 2016, we were invited back to the site to review conditions and advise on routine maintenance. At that time we proposed to re-document the buildings, this time using laser-scanning. Laser-scanning of the exterior was performed in May of 2016, and of the interior in March 2017, each over the course of four days. This paper will make a comparison between manual and digital techniques in terms of Fallingwater’s documentation.

  16. Digital Documentation of Frank Lloyd Wright's Masterpiece, Fallingwater

    Science.gov (United States)

    Jerome, P.; Emilio, D.

    2017-08-01

    Since 1988, the professional staff of Architectural Preservation Studio (APS) has been involved with the conservation of Frank Lloyd Wright's Fallingwater in Mill Run, PA. Designed and erected from 1935 to 1939 as a weekend home for the Kauffman family, the complex consists of the main house and guest house. After five years of reports and prototype repairs, we produced a two-volume master plan. Using original Frank Lloyd Wright drawings from Avery Library as background drawings, we measured every surface and reproduced the drawings in CAD, also developing elevations of every room. Stone-by-stone drawings of every flagstone floor and terrace scheduled to be lifted were also created using overlapping film photography that was assembled into a photo mosaic. By 2005, we designed, administered and completed a four-phase exterior restoration, with the paint-stripping and repainting of interior rooms being performed during the brief winter period when the building is closed to the public on an ongoing basis. In 2016, we were invited back to the site to review conditions and advise on routine maintenance. At that time we proposed to re-document the buildings, this time using laser-scanning. Laser-scanning of the exterior was performed in May of 2016, and of the interior in March 2017, each over the course of four days. This paper will make a comparison between manual and digital techniques in terms of Fallingwater's documentation.

  17. The Frank-Starling mechanism in vertebrate cardiac myocytes.

    Science.gov (United States)

    Shiels, Holly A; White, Ed

    2008-07-01

    The Frank-Starling law of the heart applies to all classes of vertebrates. It describes how stretch of cardiac muscle, up to an optimum length, increases contractility thereby linking cardiac ejection to cardiac filling. The cellular mechanisms underlying the Frank-Starling response include an increase in myofilament sensitivity for Ca2+, decreased myofilament lattice spacing and increased thin filament cooperativity. Stretching of mammalian, amphibian and fish cardiac myocytes reveal that the functional peak of the sarcomere length (SL)-tension relationship occurs at longer SL in the non-mammalian classes. These findings correlate with in vivo cardiac function as non-mammalian vertebrates, such as fish, vary stroke volume to a relatively larger extent than mammals. Thus, it seems the length-dependent properties of individual myocytes are modified to accommodate differences in organ function, and the high extensibility of certain hearts is matched by the extensibility of their myocytes. Reasons for the differences between classes are still to be elucidated, however, the structure of mammalian ventricular myocytes, with larger widths and higher levels of passive stiffness than those from other vertebrate classes may be implicated.

  18. WARDHAUGH, Ronald. 1986. An introduction to sociolinguistics. New York: Basil Blackwell, 388pp. WARDHAUGH, Ronald. 1986. An introduction to sociolinguistics. New York: Basil Blackwell, 388pp.

    Directory of Open Access Journals (Sweden)

    José Luiz Meurer

    2008-04-01

    Full Text Available An introduction to sociolinguistics -- Una introduce° a sociolinguistica -- de Ronald Wardhaugh (RW tem por objetivo oferecer um embasamento geral a alunos em cursos de sociolinguistica ou sociologia da linguagem. Conforme observe o autor, o livro pode ser usado com alunos que estejam estudando sociolinguistica de maneira panorâmica pola primeira vez ou com alunos em cursos sobre tópicos especificos a níveis mais elevados cujos professores queiram que os mesmos se familiarizem com outros tópicos da sociolinguistica não abordados nos cursos. Além disso, essa introdução pode ser usada como um organizador de assuntos diversos que se relacionam dentro de um conjunto significativo de tópicos importantes da sociolinguistica (ver abaixo. Assim, este livro de RW sera útil tanto para principiantes como para interessados que ja tenham acumulado conhecimentos mais ou menos avançados da área.

  19. 76 FR 30557 - Office of Thrift Supervision Integration; Dodd-Frank Act Implementation

    Science.gov (United States)

    2011-05-26

    ... Title III of the Dodd-Frank Wall Street Reform and Consumer Protection Act. The OCC also is proposing amendments to its rules pertaining to change in control of credit card banks and trust banks to implement...- Frank Wall Street Reform and Consumer Protection Act, Public Law 111- 203, 124 Stat. 1376 (2010)...

  20. 75 FR 62120 - Notice of Availability of Draft Basis for Determination Under Section 3116 of the Ronald W...

    Science.gov (United States)

    2010-10-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Notice of Availability of Draft Basis for Determination Under Section 3116 of the Ronald W. Reagan National Defense Authorization Act for Fiscal Year 2005 (NDAA) for Closure of the F-Tank Farm at the Savannah...

  1. Impact of a classic paper by H. Ronald Pulliam: An overview of the first twenty years (1988-2007)

    Science.gov (United States)

    In 1988, H. Ronald Pulliam published the classic paper, “Sources, Sinks, and Population Regulation.” The message of this paper was that population dynamics can change across heterogeneous landscapes, where populations in “sink” habitats rely on inputs from “source” habitats to p...

  2. The politics of presidential illness. Ronald Reagan and the Iran-Contra Scandal.

    Science.gov (United States)

    Gilbert, Robert E

    2014-01-01

    This paper assesses the likelihood that the Iran-Contra scandal was shaped heavily by the effects of Ronald Reagan's cancer surgery in summer, 1985. During the President's hospitalization and in the period soon after, he took several actions--which he apparently did not remember--that launched a policy that was unwise, counterproductive, and a failure. These damaged both his Administration and his standing in history. The 25th Amendment afforded Reagan the means by which his involvement in these events could easily have been avoided. However, the President and his aides determined that he would resume the powers and duties of the presidency only hours after undergoing extensive cancer surgery. This decision contributed materially to the most damaging episode of Reagan's eight-year presidency.

  3. The New Secular Humanists: Ronald Dworkin and Philip Kitcher on Life without God

    Directory of Open Access Journals (Sweden)

    Charles Taliaferro

    2015-07-01

    Full Text Available Ronald Dworkin and Philip Kitcher recognize that traditional, religious faith—especially in Christian theistic tradition—has virtues that seem to be missing in a secular worldview. To remedy this apparent deficit, they both propose that a secular worldview can provide a satisfying foundation for a flourishing, meaningful life. Moreover, Kitcher argues that secular humanism is far more justified than a religious worldview because it does not face the problem of diversity that arises in the case of religion. I argue that secular humanism faces the same problem of diversity that Kitcher proposes undermines religious belief. I further argue that Dworkin’s and Kitcher’s secular alternative to a religious worldview is problematic.

  4. The Montreal General Hospital Pain Centre (1974-2000: The Contributions of Ronald Melzack

    Directory of Open Access Journals (Sweden)

    Mary Ellen Jeans

    2000-01-01

    Full Text Available This paper chronicles the development of the Montreal General Hospital Pain Centre from its inception in 1974 to the present. Highlighted in particular are the contributions of Ronald Melzack to this history. Data for the article arose, in the main, from an interview with Dr Melzack carried out earlier in the year. Discussions with former and present members of the pain centre team, including former graduate students, provided additional information. The article begins with a recounting of those individuals and events that inspired Ron early in his 'pain career' to pursue his dream of a multidisciplinary pain centre, the first of its kind in Canada. The forces that helped shape the development of this centre and the challenges that had to be overcome are described.

  5. Los Derechos Humanos en la Filosofía Analítica: Ronald Dworkin

    Directory of Open Access Journals (Sweden)

    Mauricio Beuchot

    2013-11-01

    Full Text Available The paper deals with the way Ronald Dworkin –as H. L. A. Hart and John Rawls, to whom he follows– states the foundation to human rights. Certain presence of iusnaturalism in that foundation is pointed at, for Dworkin, as Hart and Rawls, seeks which ones would be the natural rights of man (one of them says that it would be freedom, and the other two that it would be equality, i.e, they are rights that cannot depend on social contract, because they are first to them and they are presupposed to it; and because of that, they cannot depend on the sole positivation. There is, then, a hidden or latent iusnaturalism in the foundation of human rights as moral rights,

  6. Granular, soft and fuzzy approaches for intelligent systems dedicated to professor Ronald R. Yager

    CERN Document Server

    Filev, Dimitar; Beliakov, Gleb

    2017-01-01

    This book offers a comprehensive report on the state-of-the art in the broadly-intended field of “intelligent systems”. After introducing key theoretical issues, it describes a number of promising models for data and system analysis, decision making, and control. It discusses important theories, including possibility theory, the Dempster-Shafer theory, the theory of approximate reasoning, as well as computing with words, together with novel applications in various areas, such as information aggregation and fusion, linguistic data summarization, participatory learning, systems modeling, and many others. By presenting the methods in their application contexts, the book shows how granular computing, soft computing and fuzzy logic techniques can provide novel, efficient solutions to real-world problems. It is dedicated to Professor Ronald R. Yager for his great scientific and scholarly achievements, and for his long-lasting service to the fuzzy logic, and the artificial and computational intelligence communit...

  7. Frank-Starling心脏定律探讨—Frank-Starling定律并非定律%To Investigate the Frank-Starling Law of the Heart——the Frank-Starling law is not a law

    Institute of Scientific and Technical Information of China (English)

    何川; 何培芳

    2012-01-01

    The law of the heart,Frank-Starling Law of the Heart (FSLH),says that the energy of cardiac contraction (cardiac work) is a function of the length of the muscle fiber (MFL)/the end-diastolic volume (EDV).The authors of this paper investigate into the FSLH via multidisciplinary knowledge from various angles and hold that:1)In the heart-lung preparation devised by Starling and his colleagues,which was aimed at studying the relationship between the inflow and cardiac work,the dog heart being put beneath the venous reservoir,relying on its own gravity,the blood in the venous reservoir flows into the right ventricle.That experimental condition is far from the physiological reality of human body vein hemodynamics.Therefore,the authors of this paper do not consider that the Frank-Starling phenomenon (the outflow increased with the rising of the filling pressure) observed in their experiments is a law of the heart working.2)The FSLH emphasizes the MFL/EDV,but it neglects the change in the MFL (e.g.,neglecting the end-systolic volume,ESV,i.e.,the end-point of the ventricular wall movement during the contraction).Lacking the ESV,the cardiac work (W) can not be calculated——the FSLH expression in the law of the heart working does not correspond to the basic principle of the “work” in physics.3)The mathematical relationship in the accepted formula for calculating the cardiac work “Stroke work =P × (EDV-ESV) ” shows that the stroke work does not always increase with the advent of the increased EDV,and does not always decrease with the advent of the decreased EDV either——there is no functional relation between the W and the EDV.Therefore,the authors of this paper hold that the FSLH expressing the fundamental principle of the heart working is a failure,and it is not a true law.%心脏搏动作功的规律:心脏收缩释放的能量(作功)是心肌纤维长度/心室舒张末期容积(EDV)的函数,即Frank-Starling心脏定律(简称“定律”),被誉为心

  8. Assessment of contractility in intact ventricular cardiomyocytes using the dimensionless 'Frank-Starling Gain' index.

    Science.gov (United States)

    Bollensdorff, Christian; Lookin, Oleg; Kohl, Peter

    2011-07-01

    This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.

  9. Frank Netter: A Man of Art and Science.

    Science.gov (United States)

    Shivakumar, Natesh; Hammad, Abdulrahman Y; Gamblin, T Clark

    2016-05-01

    Medical illustrations are highly used by medical professionals for various reasons. They have facilitated learning for many centuries and allowed a detailed analysis of subjects. Complex information on anatomy, histology, physiology, and even surgical procedures can be transformed by illustrations into a clear and accurate source that words could never fully describe. The idea that art can be used to enhance the study of science has been emphasized by many medical illustrators. One person who will always be remembered for his artwork in the modern era is Frank H. Netter. The New York native, born in 1906, is one of the era's most well-known medical illustrators. Almost all medical professionals, at one point or another, have come across one of his numerous artistic sketches during their career. Although best known for his Atlas of Human Anatomy, some of Netter's other projects include the CIBA Collection of Medical Illustrations, the "Transparent Women," and the Clinical Symposia series. Medicine lost an educator and an artist in 1991; however, his collection of illustrations remains as his lasting gift to the field.

  10. Faut-il oublier Frank Lloyd Wright ?

    Directory of Open Access Journals (Sweden)

    Arnaud Brennetot

    2007-11-01

    Full Text Available Les émotions que les habitants ressentent à l’égard de leur environnement suggèrent un rapport esthétique au territoire. La critique formelle des œuvres d’art permet d’étendre la discussion géographique au-delà des considérations techniques tout en renouvelant la compréhension des enjeux politiques que recouvrent nos existences. Le plaisir esthétique peut être l’occasion de faire entrer en résonance l’espace des architectes et celui des géographes. L’œuvre de Frank Lloyd Wright fournit une illustration possible de l’apport que représente cette approche pour l’évaluation territoriale, notamment car les recherches formelles qu’il entreprend sur l’espace en matière d’architecture domestique découlent d’une ambitieuse conception du développement territorial américain. Loin d’être hostile à l’urbanité, Wright imagine tout au long de sa carrière la forme que pourrait prendre une ville moderne résultant de la libre expression de ses habitants. Cette réflexion visionnaire peut nous aider à enrichir le regard que nous portons aujourd’hui sur la ville à venir.

  11. The LHC: a miracle in the making by Frank Close

    CERN Multimedia

    2008-01-01

    After a quarter of a century of dreaming and planning, designing and building, at last we are about to see the LHC completed. Frank Close, Rudolf Peierls Centre for Theoretical Physics, Oxford University, is a former head of CERN’s Communication Group. He recently visted CERN to give lectures to the summer students.Already the excitement is gathering at the prospect of what will be discovered: possibly the Higgs Boson, or supersymmetry, or even things that no one has thought of. The world’s media are already abuzz with anticipation. But I feel that we are getting ahead of ourselves. The visions of the new world will hopefully be tomorrow’s stories; today let’s reflect on what has been achieved at even getting to this point and recall what it was like long ago when the dream began: in those bygone days, were you sure that the LHC would ever be? We all expect it will work, particle physics has a great track record in such thing...

  12. Simulation of the Frank-Starling Law of the Heart

    Directory of Open Access Journals (Sweden)

    Samo Ribarič

    2012-01-01

    Full Text Available We developed a lumped parameter, computer-based model of an equivalent electronic circuit for a one-atrium one-ventricle (frog heart attached to a vascular circuit, to simulate a basic concept of cardiovascular physiology, the Frank-Starling Law of the Heart. A series of simulations was performed, to observe changes in cardiovascular variables (e.g., arterial pressure, ventricular volume, and valve flows if either preload or afterload was increased. The simulated data agreed qualitatively, and quantitatively when experimental data are available, with data obtained on amphibian or on mammalian myocardium. In addition, the data obtained in these simulations improve our understanding of the mechanism(s whereby the heart muscle adapts itself to increased distension (increased preload or to impeded systolic contraction (increased afterload. The analysis of the measured valve flows suggests that the ventricle is a highly input sensitive pump because the input pressure determines the diastolic distension and, consequently, the force of ventricular systolic contraction. On the other hand, the ventricle is a relatively output insensitive pump. Therefore, not only atrium contraction, but also predominantly the preceding ventricular systolic contraction is the main mechanism of the subsequent diastolic ventricular filling. We conclude that the presented model enables the study of basic concepts of cardiovascular physiology.

  13. SUSTAINABLE ORIGINS IN ARCHITECTURE OF FRANK LLOYD WRIGHT

    Directory of Open Access Journals (Sweden)

    Martina Zbašnik-Senegačnik

    2012-10-01

    Full Text Available Frank Lloyd Wright is the greatest American architect and oneof the greatest architects the world. His career began at theend of the 19th century, during the great architectural boom inChicago, under the mentorship of Louis Henry Sullivan, fromwhom he adopted and then perfected the concepts of organicarchitecture and the Prairie house. During the Depressionyears, Wright developed a cheaper and simpler variant of thePrairie house: the Usonian house.Wright's architecture is characterised by an entirely newapproach to building design, particularly the design of houses.He reduced the number of rooms by combining their functionsin a large living space with a central fireplace. He used largeglazed areas to connect the external environment of the housewith the interior. The natural environment of the prairie wasthe inspiration for the horizontal lines that characterised hisarchitecture. His buildings are low in height, close to humanscale and with a great feeling for the natural setting in whichthey are built. He selected materials from the surroundingarea and the principal decoration of his architecture was thenatural structure of the material.The paper presents the ideas of organic architecture, thePrairie house, the Usonian house, along with the best examplesof Wright's architecture and the criteria he employed in theselection of materials and construction technologies. Theenvironmental aspect of his philosophy of the use of materialsis considered in the discussion section.Wright may be considered a pioneer of sustainable architecture.

  14. Frank-starling control of a left ventricular assist device.

    Science.gov (United States)

    Stevens, Michael Charles; Gaddum, Nicholas Richard; Pearcy, Mark; Salamonsen, Robert F; Timms, Daniel Lee; Mason, David Glen; Fraser, John F

    2011-01-01

    A physiological control system was developed for a rotary left ventricular assist device (LVAD) in which the target pump flow rate (LVADQ) was set as a function of left atrial pressure (LAP), mimicking the Frank-Starling mechanism. The control strategy was implemented using linear PID control and was evaluated in a pulsatile mock circulation loop using a prototyped centrifugal pump by varying pulmonary vascular resistance to alter venous return. The control strategy automatically varied pump speed (2460 to 1740 to 2700 RPM) in response to a decrease and subsequent increase in venous return. In contrast, a fixed-speed pump caused a simulated ventricular suction event during low venous return and higher ventricular volumes during high venous return. The preload sensitivity was increased from 0.011 L/min/mmHg in fixed speed mode to 0.47L/min/mmHg, a value similar to that of the native healthy heart. The sensitivity varied automatically to maintain the LAP and LVADQ within a predefined zone. This control strategy requires the implantation of a pressure sensor in the left atrium and a flow sensor around the outflow cannula of the LVAD. However, appropriate pressure sensor technology is not yet commercially available and so an alternative measure of preload such as pulsatility of pump signals should be investigated.

  15. Simulation of the Frank-Starling Law of the Heart.

    Science.gov (United States)

    Ribarič, Samo; Kordaš, Marjan

    2012-01-01

    We developed a lumped parameter, computer-based model of an equivalent electronic circuit for a one-atrium one-ventricle (frog) heart attached to a vascular circuit, to simulate a basic concept of cardiovascular physiology, the Frank-Starling Law of the Heart. A series of simulations was performed, to observe changes in cardiovascular variables (e.g., arterial pressure, ventricular volume, and valve flows) if either preload or afterload was increased. The simulated data agreed qualitatively, and quantitatively when experimental data are available, with data obtained on amphibian or on mammalian myocardium. In addition, the data obtained in these simulations improve our understanding of the mechanism(s) whereby the heart muscle adapts itself to increased distension (increased preload) or to impeded systolic contraction (increased afterload). The analysis of the measured valve flows suggests that the ventricle is a highly input sensitive pump because the input pressure determines the diastolic distension and, consequently, the force of ventricular systolic contraction. On the other hand, the ventricle is a relatively output insensitive pump. Therefore, not only atrium contraction, but also predominantly the preceding ventricular systolic contraction is the main mechanism of the subsequent diastolic ventricular filling. We conclude that the presented model enables the study of basic concepts of cardiovascular physiology.

  16. Frank Gwazdauskas honored with the American Dairy Science Association Fellow Award

    OpenAIRE

    Greiner, Lori A.

    2008-01-01

    Frank C. Gwazdauskas of Blacksburg, Va., the David and Margaret Lincicome Professor in the Department of Dairy Science in Virginia Tech's College of Agriculture and Life Sciences, received the 2008 American Dairy Science Association (ADSA) Fellow Award.

  17. Effect of thermal stress on Frank-Starling relations in humans

    DEFF Research Database (Denmark)

    Wilson, T.E.; Brothers, R.M.; Tollund, C.

    2009-01-01

    The Frank-Starling 'law of the heart' is implicated in certain types of orthostatic intolerance in humans. Environmental conditions have the capacity to modulate orthostatic tolerance, where heat stress decreases and cooling increases orthostatic tolerance. The objective of this project was to test...... the hypothesis that heat stress augments and cooling attenuates orthostatic-induced decreases in stroke volume (SV) via altering the operating position on a Frank-Starling curve. Pulmonary artery catheters were placed in 11 subjects for measures of pulmonary capillary wedge pressure (PCWP) and SV (thermodilution...... in PCWP. In contrast, heating values were located on the steeper portion of a Frank-Starling curve because of augmented decreases in SV per decrease in PCWP. These data suggest that a Frank-Starling mechanism may contribute to improvements in orthostatic tolerance during cold stress and orthostatic...

  18. Reconstitution of the Frank-Starling Mechanism in Engineered Heart Tissues

    OpenAIRE

    Asnes, Clara F.; Marquez, J. Pablo; Elson, Elliot L.; Wakatsuki, Tetsuro

    2006-01-01

    According to the Frank-Starling mechanism, as the heart is stretched, it increases its contraction force. Reconstitution of the Frank-Starling mechanism is an important milestone for producing functional heart tissue constructs. Spontaneously contracting engineered heart tissues (EHTs) were reconstituted by growing dissociated chicken embryo cardiomyocytes in collagen matrices. Twitch and baseline tensions were recorded at precisely controlled levels of tissue strain. The EHTs showed a steep ...

  19. Frank-Starling心脏定律——Frank-Starling定律并非定律%A Comment on the Frank-Starling Law of the Heart——The Frank-Starling Law is not a Law

    Institute of Scientific and Technical Information of China (English)

    何川; 何培芳

    2009-01-01

    心脏收缩释放的能量(作功)是心肌纤维长度(心室舒张末期容积,EDV)的函数,即Frank-Starling(FS)心脏作功定律,被誉为心脏生理学中的"经典"理论,对此,笔者从各种不同角度进行了探讨:首先分析了Frank伸展离体心肌和Starling心肺制备实验与动物生理学实际的差异、以及人们在实验中观测到的增加心肌前负荷引起其收缩力增强的现象(FS现象),认为(1)在正常生理条件下的动物体内,来自心脏以外的、如同Starling心肺制备实验中那样人工控制心室充盈压力升高、引起EDV增加的那种血液的重力动力是不存在的;(2)另一方面,人为地增加前负荷,那是改变了心肌收缩时的外环境条件;(3)由此而激发出的FS现象,是心脏适应其外环境条件变化所作出的反应;(4)此种心肌收缩力增强的反应,需通过心肌细胞内部与收缩过程发生有关的心肌兴奋收缩和化学力学偶联等一系列生化机制(不恒定因素)方能得以实现;因此(5)根据他们实验中观测到的FS现象,在逻辑上不能得出前负荷这一心肌收缩时的外环境条件变化调控其作功的推论,换言之,所有的在实验中被激发出来的FS现象,都不足以成为支持FS心脏定律的证据.然后,引用国内外公认的计算心脏每搏射血作功(W)的生物物理学公式"W=PX(EDV-ESV)",证明了W和EDV之间没有函数关系.根据心脏作功的生物物理学基本原理,笔者认为Frank-Starling心脏定律表达的不是心脏作功的规律.

  20. Frank-ter Haar syndrome associated with sagittal craniosynostosis and raised intracranial pressure

    Directory of Open Access Journals (Sweden)

    Bendon Charlotte L

    2012-11-01

    Full Text Available Abstract Background Frank-ter Haar syndrome is a rare disorder associated with skeletal, cardiac, ocular and craniofacial features including hypertelorism and brachycephaly. The most common underlying genetic defect in Frank-ter Haar syndrome appears to be a mutation in the SH3PXD2B gene on chromosome 5q35.1. Craniosynostosis, or premature fusion of the calvarial sutures, has not previously been described in Frank-ter Haar syndrome. Case presentation We present a family of three affected siblings born to consanguineous parents with clinical features in keeping with a diagnosis of Frank-ter Haar syndrome. All three siblings have a novel mutation caused by the deletion of exon 13 of the SH3PXD2B gene. Two of the three siblings also have non-scaphocephalic sagittal synostosis associated with raised intracranial pressure. Conclusion The clinical features of craniosynostosis and raised intracranial pressure in this family with a confirmed diagnosis of Frank-ter Haar syndrome expand the clinical spectrum of the disease. The abnormal cranial proportions in a mouse model of the disease suggests that the association is not coincidental. The possibility of craniosynostosis should be considered in individuals with a suspected diagnosis of Frank-ter Haar syndrome.

  1. Frank-ter Haar syndrome associated with sagittal craniosynostosis and raised intracranial pressure.

    Science.gov (United States)

    Bendon, Charlotte L; Fenwick, Aimée L; Hurst, Jane A; Nürnberg, Gudrun; Nürnberg, Peter; Wall, Steven A; Wilkie, Andrew O M; Johnson, David

    2012-11-09

    Frank-ter Haar syndrome is a rare disorder associated with skeletal, cardiac, ocular and craniofacial features including hypertelorism and brachycephaly. The most common underlying genetic defect in Frank-ter Haar syndrome appears to be a mutation in the SH3PXD2B gene on chromosome 5q35.1. Craniosynostosis, or premature fusion of the calvarial sutures, has not previously been described in Frank-ter Haar syndrome. We present a family of three affected siblings born to consanguineous parents with clinical features in keeping with a diagnosis of Frank-ter Haar syndrome. All three siblings have a novel mutation caused by the deletion of exon 13 of the SH3PXD2B gene. Two of the three siblings also have non-scaphocephalic sagittal synostosis associated with raised intracranial pressure. The clinical features of craniosynostosis and raised intracranial pressure in this family with a confirmed diagnosis of Frank-ter Haar syndrome expand the clinical spectrum of the disease. The abnormal cranial proportions in a mouse model of the disease suggests that the association is not coincidental. The possibility of craniosynostosis should be considered in individuals with a suspected diagnosis of Frank-ter Haar syndrome.

  2. Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia

    Science.gov (United States)

    Graham, Naida L.; Leonard, Carol; Tang-Wai, David F.; Black, Sandra; Chow, Tiffany W.; Scott, Chris J.M.; McNeely, Alicia A.; Masellis, Mario; Rochon, Elizabeth

    2016-01-01

    Background/Aims Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients when this feature is not required for diagnosis. Method We assessed grammatical production in 9 patients who satisfied current diagnostic criteria. Although the focus was agrammatism, motor speech skills were also evaluated to determine whether dysfluency arose primarily from apraxia of speech (AOS), instead of, or in addition to, agrammatism. Volumetric MRI analyses provided impartial imaging-supported diagnosis. Results The majority of cases exhibited neither frank agrammatism nor AOS. Conclusion There are nfPPA patients with imaging-supported diagnosis and preserved motor speech skills who do not exhibit frank agrammatism, and this may persist beyond the earliest stages of the illness. Because absence of frank agrammatism is a subsidiary diagnostic feature in the logopenic variant of PPA, this result has implications for differentiation of the nonfluent and logopenic variants, and indicates that PPA patients with nonfluent speech in the absence of frank agrammatism or AOS do not necessarily have the logopenic variant.

  3. A comparative reading of John Steinbeck's and Frank Hardy's works

    Directory of Open Access Journals (Sweden)

    Danica Čerče

    2006-12-01

    Full Text Available Although belonging to literatures spatially and traditionally very remote from each other, John Steinbeck, an American Nobel Prize winner, and Frank Hardy, an Australian novelist and story-teller, share a number of common grounds. The fact that by the time Hardy wrote his first novel, in 1950, Steinbeck was already a popular writer with a long list of masterpieces does not justify the assumption that Hardy had Steinbeck at hand when writing his best-sellers, but it does exclude the opposite direction of inheritance. Hardy's creativ impulses and appropriations may have been the unconscious results of his omnivorous reading after he realized that "the transition from short stories [in which he excelled] to the novel was an obstacle not easily surmounted" as he confessed in The Hard Way: The Story Behind "Power Without Glory" (109. Furthermore, since both were highly regarded proletarian writers in communist Russia, Hardy might have become acquainted with Steinbeck's novels on one of his frequent visits to that country between 1951 and 1969.2 Upon closer reading, inter-textual entanglements with Steinbeck's prose can be detected in several of his books, including But the Dead Are Many (1975, the Billy Borker material collected in The Yarns of Billy Barker (1965 and in The Great Australian Lover and Other Stories (1967, and in Power Without Glory (1950. My purpose in this essay is to briefly illuminate the most striking similarities between the two authors' narrative strategies in terms of their writing style, narrative technique, and subject matter, and link these textual affinities to the larger social and cultural milieu of each author. In the second part I will focus on the parallels between their central works, Steinbeck's The Grapes of Wrath and Hardy's Power Without Glory.

  4. Ronald Dworkin desde la tradición romano-germánica

    Directory of Open Access Journals (Sweden)

    Francisco Tortorelo Cervante

    2007-12-01

    Full Text Available La frase “Gobierno de los jueces” se ha popularizado como crítica a las decisiones de los jueces constitucionales que parecen contravenir la voluntad del legislador. El orden constitucional debe cuidar entonces que los intérpretes constitucionales no ejerzan un papel demasiado participativo en las decisiones políticas de cada país, por lo que la actividad interpretativa tendría que evolucionar en torno a valores establecidos en la Constitución y no en torno a lo que los jueces entiendan individualmente como moral objetiva. Por esto es necesario permitir que los jueces constitucionales se inspiren por principios y directivas que orienten la aplicación de sus decisiones. La obra de Ronald Dworkin explora estos criterios normativos que pueden reducir la discrecionalidad judicial y este artículo analiza cómo aplicar sus ideas al respecto en la tradición romano-germánica del derecho.

  5. 质疑Frank-Starling心脏定律%Doubts about the Frank-Starling Law of Heart

    Institute of Scientific and Technical Information of China (English)

    何川; 何培芳

    2009-01-01

    心脏收缩释放的能量(作功)是心肌纤维长度(心室舒张末期容积,EDV)的函数,即Frank-Star-ling(FS)心脏作功定律,被誉为心脏生理学中的"经典"理论.对此,笔者从各种不同角度进行了探讨:首先分析了Frank伸展离体心肌和Starling及其同事使用心肺制备做的实验与动物生理实际的差异,以及人们在实验中观测到的增加心肌前负荷引起收缩力增强的现象(FS现象),认为:①在正常生理条件下的动物体内,来自心脏以外的、如同心肺制备中那样人工控制心室充盈压力升高、引起EDV增加的那种血液的重力动力是不存在的.②另一方面,人为地增加前负荷,那是改变了心肌收缩时的外环境条件.③由此而激发出的FS现象,是心脏适应其外环境条件变化所作出的反应.④此种心肌收缩力增强的反应,需通过心肌细胞内部与收缩过程发生有关的心肌兴奋-收缩和化学-力学偶联等一系列生化机制(不恒定因素)方能得以实现.⑤根据他们实验中观测到的FS现象,在逻辑上不能得出前负荷这一心肌收缩时的外环境条件变化调控其作功的推论.换言之,所有的在实验中被激发出来的FS现象,都不足以成为支持FS心脏定律的证据.然后,引用国内外公认的计算心脏每搏射血作功(W)的生物物理学公式"W=P×(EDV-ESV)",证明了W和EDV之间没有函数关系.根据心脏作功的医用物理学和生物数学的基本原理,笔者认为Frank-Starling心脏定律表达的不是心脏作功的规律.

  6. A printed, dry electrode Frank configuration vest for ambulatory vectorcardiographic monitoring

    Science.gov (United States)

    Paul, Gordon; Torah, Russel; Beeby, Steve; Tudor, John

    2017-02-01

    This paper describes the design and fabrication of a screen printed network of bio-potential measurement electrodes on a garment, in this case a vest. The electrodes are placed according to the Frank configuration, which allows monitoring of the electrical behavior of the heart in three spatial orientations. The vest is designed to provide stable contact pressure on the electrodes. The electrodes are fabricated from stencil printed carbon loaded rubber and are connected by screen printed silver polymer conductive tracks to an array of vias, which form an electrical connection to the other side of the textile. The vest is tested and compared to Frank configuration recordings that were obtained using standard self-adhesive ECG electrodes. The vest was successfully used to obtain Frank configuration recordings with minimal baseline drift. The vest is fabricated using only technologies found in standard textile production lines and can be used with a reduced setup effort compared to clinical 12-lead examinations.

  7. Frank Close presents his book "Neutrino" and a forthcoming book on Bruno Pontecorvo

    CERN Multimedia

    2013-01-01

    Frank Close's book "Neutrino" is short listed for the Italian Galileo Prize. Frank describes how he was inspired to write about Ray Davis' heroic quest to do what many thought was impossible: detecting neutrinos from the sun. He will also describe how he has, in turn, become fascinated by the life and work of "Mr Neutrino" - Bruno Pontecorvo - and is writing a biography of him.   By choosing to move to the USSR suddenly in 1950, Pontecorvo missed out on getting full credit for several seminal ideas about neutrinos including, possibly, their discovery. Why he went to the USSR so suddenly has been unresolved for 60 years. Frank's book "A Life of Two Halves" may answer this question, in 2014. He will update on progress so far. Wednesday 17 April at 4 p.m. in the Library, 52-1-052 Tea and coffee will be served from 3:30 p.m. Here on Indico.

  8. Replication of the Frank-Starling response in a mock circulation loop.

    Science.gov (United States)

    Gregory, Shaun D; Stevens, Michael; Timms, Daniel; Pearcy, Mark

    2011-01-01

    Mock circulation loops (MCLs) are used to evaluate cardiovascular devices prior to in-vivo trials; however they lack the vital autoregulatory responses that occur in humans. This study aimed to develop and implement a left and right ventricular Frank-Starling response in a MCL. A proportional controller based on ventricular end diastolic volume was used to control the driving pressure of the MCL's pneumatically operated ventricles. Ventricular pressure-volume loops and end systolic pressure-volume relationships were produced for a variety of healthy and pathological conditions and compared with human data to validate the simulated Frank-Starling response. The non-linear Frank-Starling response produced in this study successfully altered left and right ventricular contractility with changing preload and was validated with previously reported data. This improvement to an already detailed MCL has resulted in a test rig capable of further refining cardiovascular devices and reducing the number of in-vivo trials.

  9. Assessment of the Frank-Starling relationship by two-dimensional echocardiography.

    Science.gov (United States)

    Zipprich, D A; Owen, C H; Lewis, C W; Gall, S A; Davis, J W; Kisslo, J A; Glower, D D

    1996-01-01

    The Frank-Starling relationship between left ventricular stroke work and end-diastolic minor-axis cross-sectional area was evaluated as a load-insensitive measure of inotropic state by two-dimensional echocardiography in 10 conscious dogs. Stroke work was calculated as the product of systolic change in cross-sectional area and either (1) beat-to-beat mean arterial pressure or (2) initial systolic blood pressure. Both Frank-Starling relationships were highly linear during preload variation (mean r = 0.96), sensitive to the inotropic state (slope increase with calcium 51% +/- 43% and 62% +/- 53%, respectively), and insensitive to afterload (r < 0.4, slope or x intercept versus afterload). Thus the Frank-Starling relationships derived from two-dimensional echocardiographic images and peripheral arterial pressure may be a useful and practical means of assessing inotropic state with minimally invasive measurements.

  10. β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility.

    Science.gov (United States)

    Abraham, Dennis M; Davis, Robert T; Warren, Chad M; Mao, Lan; Wolska, Beata M; Solaro, R John; Rockman, Howard A

    2016-12-13

    The Frank-Starling law of the heart is a physiological phenomenon that describes an intrinsic property of heart muscle in which increased cardiac filling leads to enhanced cardiac contractility. Identified more than a century ago, the Frank-Starling relationship is currently known to involve length-dependent enhancement of cardiac myofilament Ca(2+) sensitivity. However, the upstream molecular events that link cellular stretch to the length-dependent myofilament Ca(2+) sensitivity are poorly understood. Because the angiotensin II type 1 receptor (AT1R) and the multifunctional transducer protein β-arrestin have been shown to mediate mechanosensitive cellular signaling, we tested the hypothesis that these two proteins are involved in the Frank-Starling mechanism of the heart. Using invasive hemodynamics, we found that mice lacking β-arrestin 1, β-arrestin 2, or AT1R were unable to generate a Frank-Starling force in response to changes in cardiac volume. Although wild-type mice pretreated with the conventional AT1R blocker losartan were unable to enhance cardiac contractility with volume loading, treatment with a β-arrestin-biased AT1R ligand to selectively activate β-arrestin signaling preserved the Frank-Starling relationship. Importantly, in skinned muscle fiber preparations, we found markedly impaired length-dependent myofilament Ca(2+) sensitivity in β-arrestin 1, β-arrestin 2, and AT1R knockout mice. Our data reveal β-arrestin 1, β-arrestin 2, and AT1R as key regulatory molecules in the Frank-Starling mechanism, which potentially can be targeted therapeutically with β-arrestin-biased AT1R ligands.

  11. La arquitectura tardía de Frank Lloyd Wright, el primer maestro moderno

    OpenAIRE

    González Capitel, Antón

    1996-01-01

    1. La arquitectura tardía de Frank Lloyd Wright, el primer maestro moderno l. l. Un Wright renovado. Talleres y residencias l. l. l. Nuevas casas de Wright en su segunda «edad de oro»: un neoplasticismo orgánico en la casa de la Cascada l. l. 2. Geometrías y disposiciones alternativas l. 2. Arquitectura y ciudad orgánicas 1. 2. 1. El desarrollo de la arquitectura orgánica 1. 3. Arquitecturas relacionadas con la de Frank Lloyd Wright entre los emigrados europeos: Schindler y...

  12. Great 21st century physician ‘One Health’ leader dies. Ronald M. Davis, MD

    Directory of Open Access Journals (Sweden)

    Bruce Kaplan

    2009-03-01

    Full Text Available It is with tremendous sadness that we report the passing, on 6 November 2008, of Ronald M. Davis, MD, past President of the American Medical Association (AMA and a major supporter of the One Health Initiative. Indeed, the AMA wouldn't have passed its historic One Health Resolution without Ron's leadership. As the first preventive medicine physician to be president of the AMA, he recognised the need for collaboration between veterinarians and physicians. As he said, ‘I was primed for the issue of One Health’.Roger Mahr, who was President of the AVMA at the same time, contacted Ron to discuss bringing animal and human medicine together. They met and had dinner together. After Roger educated Ron about the issues, Ron told him that he would be happy to help. Ron not only advocated One Health principles within AMA, but he personally represented AMA on the AVMA One Health Initiative Task Force and contributed materially to the development of the Task Force recommendations (www.avma.org/onehealth/.This was a case where the right people were in the right place at the right time. In our subsequent One Health collaborations regarding drafting the AMA One Health Resolution and other related issues, Ron always graciously and expeditiously supported and guided our efforts with much wisdom.Tragically, not long after the AMA passed the One Health Resolution in June 2007, Ron was diagnosed with stage 4 pancreatic cancer.He fought the disease with grace and dignity. The New York Times reported on his battle. (www.nytimes.com/2008/09/23/health/23voic.html?partner=rssnyt&emc=rss.On 14 June 2008, at the AMA Annual Meeting of the House of Delegates, Ron gave a very moving speech entitled Legacies in the circle of life. The transcript can be read at www.ama-assn.org/ama/no-index/news-events/18670.shtml and the video can be watched at www.webguild.com/TeamRon/.The world has lost a great man and we have lost an esteemed colleague, friend, and One Health champion

  13. For an aesthetics of communication: Interview with Frank Hartmann Por uma estética da comunicação: entrevista com Frank Hartmann

    Directory of Open Access Journals (Sweden)

    Lucia Leao

    2011-07-01

    Full Text Available In August 18, 2010, Frank Hartmann was present at the Post Graduate Program in Communication and Semiotics of PUC-SP, where he lectured on the following theme: “Towards an aesthetics of communication”. Frank Hartmann is full professor at the Bauhaus University, Weimar in Germany and external faculty member at the Dept. of Communication, University of Vienna, Austria. He is the author, among others, of: Medien und Kommunikation (2008; Mediologie - Ansatz einer der Medientheorie Kulturwissenschaften (2003, and Medienphilosophie (2000. More information on his website: http://www.medienphilosophie.net/f_hartmann.htmlFrank Hartmann esteve no dia 18 de agosto de 2010 no Programa de Pós-Graduação em Comunicação e Semiótica da PUC-SP, onde proferiu a palestra “Towards an aesthetics of communication”. Hartmann é professor titular da Universidade Bauhaus, em Weimar, na Alemanha e professor convidado do Departamento de Comunicação da Universidade de Viena, na Áustria. É autor, entre outros, de: Medien und Kommunikation (2008; Mediologie – Ansätze einer Medientheorie der Kulturwissenschaften (2003; e Medienphilosophie (2000. Mais informações em seu site: http://www.medienphilosophie.net/f_hartmann.html

  14. 75 FR 65442 - Disclosure for Asset-Backed Securities Required by Section 943 of the Dodd-Frank Wall Street...

    Science.gov (United States)

    2010-10-25

    ...; ] SECURITIES AND EXCHANGE COMMISSION 17 CFR Parts 229, 240, and 249 RIN 3235-AK75 Disclosure for Asset-Backed Securities Required by Section 943 of the Dodd-Frank Wall Street Reform and Consumer Protection Act AGENCY...-Backed Securities Required by Section 943 of the Dodd-Frank Wall Street Reform and Consumer Protection...

  15. The Nation behind the Diary: Anne Frank and the Holocaust of the Dutch Jews

    Science.gov (United States)

    Foray, Jennifer L.

    2011-01-01

    Since its first appearance in 1947, "The Diary of Anne Frank" has been translated into sixty-five different languages, including Welsh, Esperanto, and Faroese. Millions and perhaps even billions of readers, scattered throughout the globe and now spanning multiple generations, are familiar with the life and work of this young Jewish…

  16. Looking and Learning: The Solomon R. Guggenheim Museum, Frank Lloyd Wright

    Science.gov (United States)

    Vatsky, Sharon

    2007-01-01

    Frank Lloyd Wright was born and raised on the farmlands of Wisconsin. His mother had a vision that her son would become a great architect. Wright was raised with strong guiding principles, a love of nature, a belief in the unity of all things, and a respect for discipline and hard work. He created the philosophy of "organic architecture," which…

  17. Frank Lloyd Wright - väike maja saab suureks : meistriklass / Pille Nagel

    Index Scriptorium Estoniae

    Nagel, Pille

    2006-01-01

    Frank Lloyd Wrighti (1867-1959) eramuloomingust. Preeriamajadest, usonia majadest, krundist ja maastikust algavast arhitektuurist, katustest ja horisontaalsusest, plaanist, tasapindade ja kõrguste muutumistest, akendest, autovarjualustest, materjalidest ja värvidest, privaatsusest ja avatusest, inimlikust mõõtmest jm. 11 värv. vaadet, plaan

  18. Frank Lloyd Wright's Hollyhock House: Los Angeles, California, 1919-1921. Instructional Resources.

    Science.gov (United States)

    Fantozzi, Carla; And Others

    1994-01-01

    Presents four lesson plans designed to teach about Frank Lloyd Wright's "Hollyhock House" to primary, intermediate, and secondary art students. Provides an overview describing the history and design of the house, including its relationship to Mayan architecture. Includes nine photographs and original drawings of the building. (CFR)

  19. Frank Buchman's Moral Re-Armament and Alfred Korzybski's General Semantics: A Comparison and Contrast.

    Science.gov (United States)

    Drake, H. L.

    This paper hypothesizes that Frank Buchman and Alfred Korzybski were aware of each other and made some comments--written or orally--about each other's work. Support for this hypothesis was developed by concentrating on correspondence, documents, and interviews relative to the two men. The paper also provides documentation about Buchman and…

  20. Religious Foundations of Culture (The Controversy Between Simon Frank and Simon Lurie on “Vekhi”

    Directory of Open Access Journals (Sweden)

    Gennadii Aliaiev

    2016-02-01

    Full Text Available The author analyses discussion that took place between S. Frank and S. Lurje concerning “Vekhi” (“Landmarks”. In this context, the author’s objective is to show the evolution of S. Frank’s outlook on culture and religion, which developed in three stages: the humanistic individualism, the religious humanism, and the Christian realism.

  1. 75 FR 66014 - Privacy of Consumer Financial Information; Conforming Amendments Under Dodd-Frank Act

    Science.gov (United States)

    2010-10-27

    ... representative.'' \\9\\ See 75 FR 55410, 55450 (Sept. 10, 2010). Title VII of the Dodd-Frank Act creates two new... Administration Board; and the Chairperson of the Corporation. \\14\\ See 75 FR 57252-02 (Sept. 20, 2010). III... COMMISSION 17 CFR Part 160 RIN 3038-AD13 Privacy of Consumer Financial Information; Conforming...

  2. 76 FR 43874 - Privacy of Consumer Financial Information; Conforming Amendments Under Dodd-Frank Act

    Science.gov (United States)

    2011-07-22

    ..., the ``Agencies'') on April 27, 2001. See 66 FR 21236, Apr. 27, 2001. On September 10, 2010, the... (the ``Dodd-Frank Act'').\\5\\ \\4\\ See 75 FR 66014, Oct. 27, 2010. \\5\\ See Public Law 111-203, 124 Stat... Federal Register to ensure a reasonable time for compliance. \\11\\ See 75 FR 57252-02, Sept. 20, 2010....

  3. A Kind and Benevolent People: The "Public" as Constructed by Congressman Barney Frank.

    Science.gov (United States)

    Herbeck, Dale A.

    News reports regarding the relationship between Massachusetts Congressman Barney Frank and a male prostitute reflect a growing willingness to hold public officials responsible for private acts. The incident triggered a classic example of apologia--a speech of self-defense. As critics have long suggested, the intangible nature of the…

  4. A new RF tagging pulse based on the Frank poly-phase perfect sequence

    DEFF Research Database (Denmark)

    Laustsen, Christoffer; Greferath, Marcus; Ringgaard, Steffen

    2014-01-01

    Radio frequency (RF) spectrally selective multiband pulses or tagging pulses, are applicable in a broad range of magnetic resonance methods. We demonstrate through simulations and experiments a new phase-modulation-only RF pulse for RF tagging based on the Frank poly-phase perfect sequence...

  5. Frank Weiner wins first place in the competition for EAAE Prize 2003 - 2005

    OpenAIRE

    Watson-Bloch, Cathy

    2005-01-01

    Frank H. Weiner, associate professor in the School of Architecture + Design has won the European Association for Architectural Education Prize 2003 -- 2005. A biennial international competition on the subject of architectural education, the EAAE Prize was first awarded in 1991, "with the aim to stimulate original writings on the subject of architectural education in order to improve the quality of architectural education in Europe."

  6. Frank Parsons's Enablers: Pauline Agassiz Shaw, Meyer Bloomfield, and Ralph Albertson

    Science.gov (United States)

    Hershenson, David B.

    2006-01-01

    Frank Parsons was not the 1st American to recognize or address the need for vocational guidance. Why he, rather than his predecessors, is credited with initiating the field can be attributed to the largely overlooked contributions of 3 other persons: Pauline Agassiz Shaw, Meyer Bloomfield, and Ralph Albertson. The author calls attention to the…

  7. A Joyful and Exhilarating Ride: An Interview with Frank J. Vattano

    Science.gov (United States)

    Dik, Bryan J.

    2008-01-01

    Frank J. Vattano is Professor Emeritus of Psychology and Emeritus University Distinguished Teaching Scholar at Colorado State University (CSU), his undergraduate alma mater. He earned his PhD in experimental psychology from The Ohio State University and served as Associate Dean of Arts and Sciences and Vice Chancellor for Student Affairs at the…

  8. Developing the Frank and Morgan technique for industrial fire risk assessment

    Directory of Open Access Journals (Sweden)

    Golmohamadi

    2013-12-01

    Conclusion: Results showed that the developed Frank and Morgan method can be a suitable tool for evaluating industrial fire risk and prioritizing units in general level of an industrial complex especially chemicals company. According to the findings in this study, the investigation of likely damages to environment in the case of fire has high importance.

  9. Geconditioneerd telen: wat leert ons het monitoring project? (interview met Theo Gieling en Frank Kempkes

    NARCIS (Netherlands)

    Arkesteijn, M.; Gieling, T.H.; Kempkes, F.L.K.

    2010-01-01

    Theo Gieling en Frank Kempkes hebben in een team met andere Wageningen UR onderzoekers negen semi-gesloten bedrijven gevolgd. Dit leidde tot een beter inzicht in wat er bij deze nieuwe manier van telen gebeurt met het kasklimaat: ontvochtiging, temperatuur- en vochtverdeling, luchtbeweging, koelen,

  10. Op zoek naar harmonie tussen politiek en bestuur. 'Politics and Administration' van Frank Goodnow

    NARCIS (Netherlands)

    Reussing, Rik

    1994-01-01

    De start van de Amerikaanse bestuurskunde wordt meestal gelegd in 1887. In dat jaar verscheen in Political Science Quarterly het artikel 'The study of administration' van Woodrow Wilson. Wilson wordt gezien als de wegbereider van de bestuurskunde, de man die de aanzet gaf. Frank Goodnow verdient de

  11. 9 CFR 319.180 - Frankfurter, frank, furter, hotdog, weiner, vienna, bologna, garlic bologna, knockwurst, and...

    Science.gov (United States)

    2010-01-01

    ..., weiner, vienna, bologna, garlic bologna, knockwurst, and similar products. 319.180 Section 319.180..., furter, hotdog, weiner, vienna, bologna, garlic bologna, knockwurst, and similar products. (a) Frankfurter, frank, furter, hot-dog, wiener, vienna, bologna, garlic bologna, knockwurst and similar...

  12. Frank Lloyd Wright - väike maja saab suureks : meistriklass / Pille Nagel

    Index Scriptorium Estoniae

    Nagel, Pille

    2006-01-01

    Frank Lloyd Wrighti (1867-1959) eramuloomingust. Preeriamajadest, usonia majadest, krundist ja maastikust algavast arhitektuurist, katustest ja horisontaalsusest, plaanist, tasapindade ja kõrguste muutumistest, akendest, autovarjualustest, materjalidest ja värvidest, privaatsusest ja avatusest, inimlikust mõõtmest jm. 11 värv. vaadet, plaan

  13. 77 FR 39571 - Frank Sherman, FSCS Corporation, TMS West Coast, Inc.,

    Science.gov (United States)

    2012-07-03

    ... Surface Transportation Board \\1\\ Frank Sherman, FSCS Corporation, TMS West Coast, Inc., \\1\\ A request for... company; TMS West Coast, Inc., a noncarrier holding company; Evergreen Trails, Inc. d/b/a Horizon Coach... company controlled by Sherman, Transportation Management Services, Inc. (TMS), obtained the right...

  14. Effect of thermal stress on Frank-Starling relations in humans.

    Science.gov (United States)

    Wilson, T E; Brothers, R M; Tollund, C; Dawson, E A; Nissen, P; Yoshiga, C C; Jons, C; Secher, N H; Crandall, C G

    2009-07-01

    The Frank-Starling 'law of the heart' is implicated in certain types of orthostatic intolerance in humans. Environmental conditions have the capacity to modulate orthostatic tolerance, where heat stress decreases and cooling increases orthostatic tolerance. The objective of this project was to test the hypothesis that heat stress augments and cooling attenuates orthostatic-induced decreases in stroke volume (SV) via altering the operating position on a Frank-Starling curve. Pulmonary artery catheters were placed in 11 subjects for measures of pulmonary capillary wedge pressure (PCWP) and SV (thermodilution derived cardiac output/heart rate). Subjects experienced lower-body negative-pressure (LBNP) of 0, 15 and 30 mmHg during normothermia, skin-surface cooling (decrease in mean skin temperature of 4.3 +/- 0.4 degrees C (mean +/- s.e.m.) via perfusing 16 degrees C water through a tubed-lined suit), and whole-body heating (increase in blood temperature of 1.0 +/- 0.1 degrees C via perfusing 46 degrees C water through the suit). SV was 123 +/- 8, 121 +/- 10, 131 +/- 7 ml prior to LBNP, during normothermia, skin-surface cooling, and whole-body heating, respectfully (P = 0.20). LBNP of 30 mmHg induced greater decreases in SV during heating (-48.7 +/- 6.7 ml) compared to normothermia (-33.2 +/- 7.4 ml) and to cooling (-10.3 +/- 2.9 ml; all P < 0.05). Relating PCWP to SV indicated that cooling values were located on the flatter portion of a Frank-Starling curve because of attenuated decreases in SV per decrease in PCWP. In contrast, heating values were located on the steeper portion of a Frank-Starling curve because of augmented decreases in SV per decrease in PCWP. These data suggest that a Frank-Starling mechanism may contribute to improvements in orthostatic tolerance during cold stress and orthostatic intolerance during heat stress.

  15. Endothelin-1 contributes to the Frank-Starling response in hypertrophic rat hearts.

    Science.gov (United States)

    Piuhola, Jarkko; Szokodi, István; Kinnunen, Pietari; Ilves, Mika; deChâtel, Rudolf; Vuolteenaho, Olli; Ruskoaho, Heikki

    2003-01-01

    Endothelin-1 is involved in mechanical load-induced cardiac growth processes; it also has effects on contractility. The interaction of endothelin-1 and the Frank-Starling response is unknown. The present study aimed to characterize the role of endothelin-1 in the regulation of the Frank-Starling response, one of the major mechanisms regulating cardiac contractile force, in both normal and hypertrophied hearts. Nontransgenic rat hearts and hypertrophic hearts of hypertensive double transgenic rats harboring human angiotensinogen and renin genes were studied in a Langendorff isolated heart setup with a liquid-filled balloon inside the left ventricle used to measure contractile parameters. The rats were studied at compensated phase, before showing any signs of heart failure. Compensated hypertrophy in double transgenic rat hearts resulted in improved contractility at a given level of preload when compared with nontransgenic rat hearts. Hearts of both rat lines showed preserved Frank-Starling responses, that is, increased contractile function in response to increased end-diastolic pressure. The mixed endothelin A/B receptor antagonist bosentan attenuated the Frank-Starling response by 53% (P<0.01) in the double transgenic hearts but not in nontransgenic hearts. The diastolic parameters remained unaffected. The left ventricles of the double transgenic rat hearts showed an 82% higher level of endothelin type A receptor mRNA and a 25% higher level of immunoreactive endothelin-1 compared with nontransgenic rat hearts. The type 1 angiotensin II receptor antagonist CV-11974 had no significant effect on contractile function in response to load in either strain. These results show that endogenous endothelin-1 contributes to the Frank-Starling response in hypertrophied rat hearts by affecting systolic performance.

  16. 伽利略启迪我们质疑Frank-Starling心脏定律%Galileo edifies us to query the Frank-Starling law of heart

    Institute of Scientific and Technical Information of China (English)

    何川; 何培芳

    2010-01-01

    心室舒张末期容积(EDV)越大心脏收缩力越强,著名的Frank-Starling心脏定律,是心脏生理学中的重要理论.伽利略启迪我们发现该定律存在着逻辑矛盾:如果增高的心室充盈压力伸展心室肌壁超过通常的舒张末期位置(心脏"扩张",DV"增加")还在其生理限度范围内时,照该定律原理,"增加"的EDV将引起每搏量和心输出量增加,心脏收缩末期心室腔内的残余血量就会减少,"扩张"的心室肌壁将自动恢复原来的体积.换言之,在正常生理条件下,心脏"扩张"(EDV"增加")是不存在的;心脏"扩张"的存在,表明其收缩力业已减低.这样,按照Frank-Starling心脏定律原理进行的逻辑推理,结果是否定了该定律自身--EDV在生理限度范围的"增加"是心脏收缩力减低的表现.据此,笔者质疑Frank-Starling心脏定律.

  17. Using Student Surveys to Monitor Teacher Effectiveness: Q&A with Dr. Ronald Ferguson. REL Mid-Atlantic Teacher Effectiveness Webinar Series

    Science.gov (United States)

    Regional Educational Laboratory Mid-Atlantic, 2013

    2013-01-01

    In this webinar, Dr. Ronald Ferguson, creator of the Tripod Project and Senior Lecturer at Harvard University Graduate School of Education, discussed the use of student surveys as an approach to measuring teacher effectiveness. This Q&A addressed the questions participants had for Dr. Ferguson following the webinar. The webinar recording and…

  18. Frank-Starling心脏定律的证明方法探讨%Discussing the Proof Method of the Frank-Starling Law of the Heart

    Institute of Scientific and Technical Information of China (English)

    何川; 何培芳

    2013-01-01

    本文目的在于探讨Frank-Starling心脏定律的科学证明方法.认为证明某一理论的真实性应该包括理论证明(引用科学概念的定义、公理和定律等去判断它的真实性)和实验证明两个方面.理论证明必须首先完成,然后才是设计合理的实验以证明该理论的真实性.理论证明和科学实验的关系是:二者均能否定错误理论,但任何实验结果都不能否定正确的理论证明.众所周知,生命现象有其独特的生物学规律,但它也服从有关的物理学、化学和数学等表达的一般物质的运动规律,因此,心脏作功遵守低级物质的运动形态规律.Frank-Starling定律对心脏搏动作功规律的表达是:心脏收缩释放的能量(作功)是心肌纤维初长度/心室舒张末期容积的函数.显然,该理论对心脏作功规律的表达没有包含收缩时心肌纤维长度的变化情况(例如,没有表达心室收缩末期容积的变化),如此表达心脏作功的规律,不符合物理学中关于作功的定义:Frank-Starling心脏定律不是一个真实的定律.既然理论证明已经十分清楚地显示了Frank-Starling心脏定律是错误的,那么,否定它,只须阐明为什么根据Frank和Starling的实验结果不能推导得出Frank-Star-ling心脏定律理论的理由而不一定再需要做出否定它的实验证明.%The method of proving the Frank-Starling Law of the Heart (FSLH) is discussed here in this paper. In order to prove the authenticity of a theory, two things are to be done: 1) deriving theoretic evidences (referring to definitions of scientific concepts, axioms and laws); 2) collecting experimental evidences. The first, the theoretic evidence should be derived. The second is to design the reasonable experiments to prove the authenticity of the theory. The relationship between the theoretic evidences and the experimental evidences is that both of them can negate a wrong theory, but any experimental results cannot

  19. 答"质疑'质疑Frank-Starling心脏定律'"%Reply to query the paper"Doubts about the Frank-Starling law of the heart"

    Institute of Scientific and Technical Information of China (English)

    何川; 何培芳

    2010-01-01

    在"心脏作功是心室舒张末期容积(EDV)的函数(Frank-Starling心脏定律)"理论中,没有包含心室收缩末期容积(ESV)这一和EDV有着同样重要意义的生理学参数.没有ESV,即只注重心脏收缩开始时心室肌壁移动的起点而不考虑其后的收缩变化,按照所述的此种心脏作功原理,每搏量(V,即EDV减去ESV)将不能确定,心脏每搏收缩作功(W)不能计算.在这种情况下,W和EDV之间不可能有函数关系--Frank-Starling心脏定律表达的不是心脏搏动作功的客观规律,它不是定律.

  20. Landau–De Gennes Theory of Nematic Liquid Crystals: the Oseen–Frank Limit and Beyond

    KAUST Repository

    Majumdar, Apala

    2009-07-07

    We study global minimizers of a continuum Landau-De Gennes energy functional for nematic liquid crystals, in three-dimensional domains, subject to uniaxial boundary conditions. We analyze the physically relevant limit of small elastic constant and show that global minimizers converge strongly, in W1,2, to a global minimizer predicted by the Oseen-Frank theory for uniaxial nematic liquid crystals with constant order parameter. Moreover, the convergence is uniform in the interior of the domain, away from the singularities of the limiting Oseen-Frank global minimizer. We obtain results on the rate of convergence of the eigenvalues and the regularity of the eigenvectors of the Landau-De Gennes global minimizer. We also study the interplay between biaxiality and uniaxiality in Landau-De Gennes global energy minimizers and obtain estimates for various related quantities such as the biaxiality parameter and the size of admissible strongly biaxial regions. © Springer-Verlag (2009).

  1. [Cardiohemodynamics and efficiency Frank-Starling mechanism in spontaneously hypertensive rats].

    Science.gov (United States)

    Dorofeieva, N O; Kuz'menko, M O; Shimans'ka, T V; Sagach, V F

    2012-01-01

    We studied cardiohemodynamics and efficiency Frank-Starling mechanism in 6-month-old spontaneously hypertensive rats (SHR) and age-matched Wistar rats, using pressure-volume (PV) conductance catheter system (Millar Instruments, Houston, TX) to evaluate systolic and diastolic function in vivo. Rats were anesthetized with urethane. Cardiohemodynamics analyzed using PVAN 3.6 (Millar Instruments). We found that systolic and diastolic function of the heart in spontaneously hypertensive rats were lower, than in controls. We have shown, inhibition of the efficiency Frank-Starling mechanism, increasing arterial stiffness in spontaneously hypertensive rats. It's shown, less efficiency heart work, with more energy and more oxygen consumption in spontaneously hypertensive rats, may be associated with increasing arterial stiffness and decrease functional reserve of the heart.

  2. Holy Terror, Batman! Frank Miller’s Dark Knight and the Superhero as Hardboiled Terrorist

    OpenAIRE

    Daniele Croci

    2016-01-01

    Conceived in the late thirties as “bold humanist response to Depression-era fears of runaway scientific advance and soulless industrialism” (Morrison 2012, 6), the superhero has flourished as one of the most resilient archetypes of American popular culture. This essay analyses the literary and cultural contaminations that have engendered an unprecedented revision of the paradigm since the 1980s. In particular, it will take into account three graphic novels by American cartoonist Frank Miller ...

  3. Barbarid, plastiliinijänes, Miriam ja Frank Muller / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2003-01-01

    Nukufilm näitab 4 uut filmi : "Barbarid" (stsenaristid Andrus Kivirähk ja Hardi Volmer, režissöör H. Volmer), "Porgand" (stsenarist Peep Pedmanson, režissöör Pärtel Tall), "Miriami jõulupäkapikk" (stsenaristid Leelo Tungal ja Peep Pedmanson, režissöör Mait Laas), "Kuuvaatleja" (reklaamitreiler Frank Mulleri kellafirmale ; stsenarist, režissöör, kunstnik Mati Kütt)

  4. The Frank Ellis memorial lecture: the use of three-dimensional imaging in gynaecological radiation therapy.

    Science.gov (United States)

    Viswanathan, A N

    2008-02-01

    The use of three-dimensional image guidance in radiation therapy has increased dramatically over the past decade. In gynaecological malignancies, three-dimensional image guidance assists with both external beam and brachytherapy treatment planning, increasing the accuracy of dose delivery. During his lifetime, Frank Ellis made significant contributions to gynaecological brachytherapy. This lecture will focus on novel advances in three-dimensional image-guided radiation therapy for cervical cancer, with the ultimate goal of improving outcomes for our patients.

  5. The NO stimulator, Catestatin, improves the Frank-Starling response in normotensive and hypertensive rat hearts.

    Science.gov (United States)

    Angelone, T; Quintieri, A M; Pasqua, T; Filice, E; Cantafio, P; Scavello, F; Rocca, C; Mahata, S K; Gattuso, A; Cerra, M C

    2015-08-01

    The myocardial response to mechanical stretch (Frank-Starling law) is an important physiological cardiac determinant. Modulated by many endogenous substances, it is impaired in the presence of cardiovascular pathologies and during senescence. Catestatin (CST:hCgA352-372), a 21-amino-acid derivate of Chromogranin A (CgA), displays hypotensive/vasodilatory properties and counteracts excessive systemic and/or intra-cardiac excitatory stimuli (e.g., catecholamines and endothelin-1). CST, produced also by the myocardium, affects the heart by modulating inotropy, lusitropy and the coronary tone through a Nitric Oxide (NO)-dependent mechanism. This study evaluated the putative influence elicited by CST on the Frank-Starling response of normotensive Wistar-Kyoto (WKY) and hypertensive (SHR) hearts by using isolated and Langendorff perfused cardiac preparations. Functional changes were evaluated on aged (18-month-old) WKY rats and SHR which mimic human chronic heart failure (HF). Comparison to WKY rats, SHR showed a reduced Frank-Starling response. In both rat strains, CST administration improved myocardial mechanical response to increased end-diastolic pressures. This effect was mediated by EE/IP3K/NOS/NO/cGMP/PKG, as revealed by specific inhibitors. CST-dependent positive Frank-Starling response is paralleled by an increment in protein S-Nitrosylation. Our data suggested CST as a NO-dependent physiological modulator of the stretch-induced intrinsic regulation of the heart. This may be of particular importance in the aged hypertrophic heart, whose function is impaired because of a reduced systolic performance accompanied by delayed relaxation and increased diastolic stiffness.

  6. Titin and Troponin: Central Players in the Frank-Starling Mechanism of the Heart

    OpenAIRE

    Fukuda, Norio; Terui, Takako; Ohtsuki, Iwao; Ishiwata, Shin’ichi; Kurihara, Satoshi

    2009-01-01

    The basis of the Frank-Starling mechanism of the heart is the intrinsic ability of cardiac muscle to produce greater active force in response to stretch, a phenomenon known as length-dependent activation. A feedback mechanism transmitted from cross-bridge formation to troponin C to enhance Ca2+ binding has long been proposed to account for length-dependent activation. However, recent advances in muscle physiology research technologies have enabled the identification of other factors involved ...

  7. A.B. Frank and mycorrhizae: the challenge to evolutionary and ecologic theory.

    Science.gov (United States)

    Trappe, James M

    2005-06-01

    A. B. Frank's observations and hypotheses about mycorrhizae in 1885 flew in the face of conventional thinking of the time. He reported that what we now term ectomycorrhizae were widespread on root systems of many woody plant species in a great diversity of habitats and soils. He hypothesized that mycorrhizae represent a pervasive mutualistic symbiosis in which fungus and host nutritionally rely on each other; that the fungus extracts nutrients from both mineral soil and humus and translocates them to the tree host; and that the tree, in turn, nourishes the fungus. Initially opposed by much of the scientific community, nearly all of Frank's major hypotheses have since been unequivocally demonstrated, although many decades were required to achieve conclusive evidence. Nonetheless, the revolution in thinking about plant and fungal evolution, ecology and physiology generated by Frank is still in the process of acceptance by much of the scientific community, 120 years and tens of thousands of scientific papers since he coined the term "mycorrhiza". The reasons for this extraordinary lag time in themselves present an intriguing research subject.

  8. Nitrite is a positive modulator of the Frank-Starling response in the vertebrate heart.

    Science.gov (United States)

    Angelone, Tommaso; Gattuso, Alfonsina; Imbrogno, Sandra; Mazza, Rosa; Tota, Bruno

    2012-06-01

    Evidence from both mammalian and nonmammalian vertebrates indicates that intracardiac nitric oxide (NO) facilitates myocardial relaxation, ventricular diastolic distensibility, and, consequently, the Frank-Starling response, i.e., the preload-induced increase of cardiac output. Since nitrite ion (NO(2)(-)), the major storage pool of bioactive NO, recently emerged as a cardioprotective endogenous modulator, we explored its influence on the Frank-Starling response in eel, frog, and rat hearts, used as paradigms of fish, amphibians, and mammals, respectively. We demonstrated that, like NO, exogenous nitrite improves the Frank-Starling response in all species, as indicated by an increase of stroke volume and stroke work (eel and frog) and of left ventricular (LV) pressure and LVdP/dt max (rat), used as indexes of inotropism. Unlike in frog and rat, in eel, the positive influence of nitrite appeared to be dependent on NO synthase inhibition. In all species, the effect was sensitive to NO scavengers, independent on nitroxyl anion, and mediated by a cGMP/PKG-dependent pathway. Moreover, the nitrite treatment increased S-nitrosylation of lower-molecular-weight proteins in cytosolic and membrane fractions. These results suggest that nitrite acts as a physiological source of NO, modulating through different species-specific mechanisms, the stretch-induced intrinsic regulation of the vertebrate heart.

  9. Frank-Starling mechanism retains recirculation fraction of myocardial Ca(2+) in the beating heart.

    Science.gov (United States)

    Mizuno, J; Araki, J; Mohri, S; Minami, H; Doi, Y; Fujinaka, W; Miyaji, K; Kiyooka, T; Oshima, Y; Iribe, G; Hirakawa, M; Suga, H

    2001-12-01

    Myocardial Ca(2+) handling in excitation-contraction coupling is the second primary determinant of energy or O(2) demand in a working heart. The intracellular and extracellular routes remove myocardial Ca(2+) that was released into the sarcoplasma with different Ca(2+): ATP stoichiometries. The intracellular route is twice as economical as the extracellular route. Therefore the fraction of total Ca(2+) removed via the sarcoplasmic reticulum, i.e., the recirculation fraction of intracellular Ca(2+) (RF), determines the economy of myocardial Ca(2+) handling. RF has conventionally been estimated as the exponential decay rate of postextrasystolic potentiation (PESP). However, we have found that PESP usually decays in alternans, but not exponentially in the canine left ventricle beating above 100 beats/min. We have succeeded in estimating RF from the exponential decay component of an alternans PESP. We previously found that the Frank-Starling mechanism or varied ventricular preload did not affect the economy of myocardial Ca(2+) handling. Then, to account for this important finding, we hypothesized that the Frank-Starling mechanism would not affect RF at a constant heart rate. We tested this hypothesis and found its supportive evidence in 11 canine left ventricles. We conclude that RF at a constant heart rate would remain constant, independent of the Frank-Starling mechanism.

  10. Frank Aggregation Operators for Triangular Interval Type-2 Fuzzy Set and Its Application in Multiple Attribute Group Decision Making

    Directory of Open Access Journals (Sweden)

    Jindong Qin

    2014-01-01

    Full Text Available This paper investigates an approach to multiple attribute group decision-making (MAGDM problems, in which the individual assessments are in the form of triangle interval type-2 fuzzy numbers (TIT2FNs. Firstly, some Frank operation laws of triangle interval type-2 fuzzy set (TIT2FS are defined. Secondly, some Frank aggregation operators such as the triangle interval type-2 fuzzy Frank weighted averaging (TIT2FFWA operator and the triangle interval type-2 fuzzy Frank weighted geometric (TIT2FFWG operator are developed for aggregation TIT2FNs. Furthermore, some desirable properties of the two aggregation operators are analyzed in detail. Finally, an approach based on TIT2FFWA (or TIT2FFWG operator to solve MAGDM is developed. An illustrative example about supplier selection is provided to illustrate the developed procedures. The results demonstrate the practicality and effectiveness of our new method.

  11. All Publishers are Paper Tigers or Frank Hardy and Bruce Pascoe Give Advice to Budding Short Story Writers.

    Science.gov (United States)

    Shepherd, Greg

    1984-01-01

    Relates Frank Hardy's and Bruce Pascoe's advice to students in a writing class concerning what they believe to be the necessary qualities of a good short story from the editing and publishing standpoint. (HOD)

  12. "Frank ja Wendy" rikub jõulud ja võtab söögiisu / Astrid Kannel

    Index Scriptorium Estoniae

    Kannel, Astrid, 1967-

    2004-01-01

    Animafilm "Frank ja Wendy" : autor David Snowman = Priit Pärn, Ülo Pikkov, Priit Tender ja Kaspar Jancis : Eesti Joonisfilm 2004. Kõik autorid vastavad midagi artikli autori provotseerivatele küsimustele

  13. "Frank ja Wendy" rikub jõulud ja võtab söögiisu / Astrid Kannel

    Index Scriptorium Estoniae

    Kannel, Astrid, 1967-

    2004-01-01

    Animafilm "Frank ja Wendy" : autor David Snowman = Priit Pärn, Ülo Pikkov, Priit Tender ja Kaspar Jancis : Eesti Joonisfilm 2004. Kõik autorid vastavad midagi artikli autori provotseerivatele küsimustele

  14. LA ESTRUCTURA ORGÁNICA EN LOS RASCACIELOS DE FRANK LLOYD WRIGHT / The organic structure in the skyscrapers of Frank Lloyd Wright

    Directory of Open Access Journals (Sweden)

    Alfonso Diaz Segura, Ricardo Meri de la Maza, Bartolomé Serra Soriano

    2013-05-01

    Full Text Available RESUMEN La estructura de la modernidad, en general, está al servicio de una nueva concepción espacial fluida y continua, condensada en torno al concepto de “planta libre”. Sin embargo, la riqueza y complejidad de articulación que adquieren las plantas, no se observa en la sección de los edificios, especialmente si se trata de rascacielos. El principio de crecimiento por superposición de plantas iguales y el carácter utilitario de la estructura en esta tipología, anularon su carácter iconográfico y su integración espacial. Frank Lloyd Wright, de modo natural, desarrolla una estructura para sus escasos rascacielos que integra espacio y forma, superando así tanto la simplificación funcional de la Escuela de Chicago, como el valor iconográfico de las experiencias europeas.SUMMARY In general, the structure of modernity serves a new, fluid and continuous, spatial conception, condensed around the “free floor” concept. However, the wealth and complexity of articulation that these floors acquire are not seen in the section of the buildings, especially in the case of skyscrapers. The principle of growth by superimposition of equal floors and the utilitarian character of the structure in this type of building, nullify the iconographic character of the structure and its spatial integration. Frank Lloyd Wright develops a structure for his few skyscrapers that integrates space and form in a natural way, thus surpassing both the functional simplification of the Chicago School, and the iconographic value of the European experiences.

  15. Underway physical and meteorological data collected by NOAA Ship RONALD H BROWN in the North Atlantic and Caribbean Sea from 2004-02-12 to 2004-04-13 (NCEI Accession 0001445)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature, conductivity, wind speed/direction, and other data were collected using meteorological sensors and a thermosalinograph from NOAA Ship RONALD H. BROWN...

  16. Underway and profile, chemical and physical data collected aboard NOAA Ship Ronald H. Brown in the East Coast of the United States and Gulf of Mexico from 2007-05-11 to 2007-08-04 (NODC Accession 0083633)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0083633 includes chemical, discrete bottle, physical, profile, underway - surface data collected aboard NOAA Ship RONALD H. BROWN in East Coast -...

  17. Current profile data collected aboard NOAA Ship Ronald Brown during cruise RB0708 in the North Atlantic Ocean and coastal waters of Florida from 2007-09-11 to 2007-09-22 (NCEI Accession 0131294)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0131294 includes physical underway data collected aboard NOAA Ship Ronald Brown during cruise RB0708 in the North Atlantic Ocean and coastal waters of...

  18. Statement of Ronald E. Lambertson, U.S. Fish and Wildlife Service, Department of the Interior, before the House Subcommittee on Public Lands and National Parks concerning National Wildlife Refuge additions to the National Wilderness Preservation System

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a statement on the Mattamuskeet, Cedar Island, and Pea Island Wildlife Refuges. Given by Ronald E. Lambertson, it says that there are almost no...

  19. Oceanographic temperature and salinity measurements collected using CTD and XBT from NOAA Ship Nancy Foster/Ronald H Brown in the North Atlantic from 1998 to 2007 (NCEI Accession 0043165)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature, salinity and other measurements found in datasets XBT and CTD taken from NOAA Ship RONALD H. BROWN (NOAA SHIP - Call Sign WTEC)(formerly NOAA Ship...

  20. Temperature profile and pressure data from CTD casts from NOAA Ship RONALD H. BROWN and NOAA Ship KA'IMIMOANA in the TOGA area of Pacific Ocean from 1997-08-05 to 1999-06-28 (NCEI Accession 9900141)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and pressure data were collected using CTD casts in the TOGA area of Pacific Ocean from NOAA Ship RONALD H. BROWN and NOAA Ship KA'IMIMOANA from...

  1. Current meter components, physical, and other data from current meters and CTD casts from NOAA Ship RONALD H. BROWN and other platforms as part of the VENTS program from 14 June 1996 to 05 October 1997 (NODC Accession 9800031)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current meter components and physical data were collected from current meters and CTD casts from NOAA Ship RONALD H. BROWN and other platforms from 14 June 1996 to...

  2. Functional significance of the Frank-Starling mechanism under physiological and pathophysiological conditions.

    Science.gov (United States)

    Jacob, R; Dierberger, B; Kissling, G

    1992-11-01

    The functional significance of the Frank-Starling mechanism under physiological and pathophysiological conditions is discussed, based mainly on animal experiment results (in the dog, pig and rat). The dependence of individual stroke volume on end-diastolic volume can be described adequately using Frank's diagram. This can be illustrated by varying filling pressure (respiratory cycle, vascular tone in the capacitance system, body position, circulating blood volume) and by alterations in the duration of the filling period (heart rate and rhythm, rate of relaxation) and in ventricular compliance (wall thickness, fibrosis; contracture, rigor). The functional importance of the Frank-Starling mechanism lies mainly in adapting left to right ventricular output. During upright physical exercise an increase in end-diastolic volume due to the action of the peripheral muscle pump and increased venous tone can assist in enhancing stroke volume. Reduced contractility leads to a shift of the operating point to the right in the pressure-volume diagram, thus tending to prevent a decrease in stroke volume. However, the consequences of increased circulating blood volume in chronic heart failure are, as a rule, mainly detrimental (congestive symptoms; myocardial component of coronary resistance; cardiac energetics). Reduced contractility results in a flattening of the relation between stroke volume (or stroke work) and end-diastolic volume. Furthermore, the Starling mechanism is prevented from becoming effective if the sarcomere-length reserve is exhausted, or in the presence of inadequate sarcomere extension due to impaired relaxation or reduced distensibility of the ventricular wall. The latter is illustrated using the example of a dilated fibrotic left ventricle from a rat with experimental supravalvular aortic stenosis.

  3. Palaeopathology of the earlobe crease (Frank's sign): New insights from Renaissance art.

    Science.gov (United States)

    Galassi, Francesco M; Borghi, Claudio; Ballestriero, Roberta; Habicht, Michael E; Henneberg, Maciej; Rühli, Frank J

    2017-06-01

    Several studies have associated the earlobe crease sign, discovered by Sanders T. Frank in 1973, with cardiovascular pathology, yet very few studies have focused on the antiquity of this trait, with the most ancient one thought to date back to the Roman Emperor Hadrian (76-138CE). This article presents two more cases from the Italian Renaissance in the works of the artist Andrea Mantegna (1431-1506) and examines them in a multidisciplinary fashion. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Quasiperiodic Frank-Kasper phases derived from the square-triangle dodecagonal tiling

    CERN Document Server

    Sadoc, Jean-François

    2016-01-01

    Frank-Kasper (F-K) phases form an important set of large-cell crystalline structures describing many inter-metallic alloys. They are usually described in term of their atomic environments, with atoms having $12, 14, 15$ and $16$ neighbours, coded into the canonical $Z_p$ cells (with $p$ the coordination number), the case $p=12$ corresponding to a local icosahedral environment. In addition, the long range structure is captured by the geometry of a network (called either "major skeleton" or "disclination network") connecting only the non-icosahedral sites (with $p\

  5. Impotent Masculinities in Frank Wedekind’s «Erdgeist»

    Directory of Open Access Journals (Sweden)

    Stephanie E. Libbon

    2013-11-01

    Full Text Available For most of recorded history, the study of impotence fell under the purview of healers. This changed in the late nineteenth century, however, as the works of avant garde artists like the German dramatist and social critic Frank Wedekind ushered analyses of this malady into public discourse. In looking first at conditions in Europe during Wedekind’s time and then tracing the history of impotence from the Ancient Chinese up to Wedekind’s day, this article investigates how Wedekind’s representations of impotence emblematized not only his own personal afflictions but a greater cultural malaise.

  6. Poesia y Pintura: Frank O'Hara y el expresinionismo abstracto

    OpenAIRE

    Alberto Santamaría

    2015-01-01

    El objetivo de este artículo es analizar las relaciones entre poesía y pintura en el seno del expresionismo abstracto. Para ello tomamos tres nombres de referencia: Clement Greenberg (crítico de arte), Frank O'Hara (poeta) y Willem De Kooning (pintor). A través de estos nombres tratamos de señalar la estrecha relación que existía entre poetas y pintores en la llamada Escuela de Nueva York.

  7. Evaluasi Premi Polis Last Survivor Pasangan Suami Istri Menggunakan Metode Copula Frank

    Directory of Open Access Journals (Sweden)

    Irma Fauziah

    2013-11-01

    Full Text Available Tulisan ini mengkaji tentang sebuah produk asuransi, ketahanan hidup, yang didasarkan pada dua kelompok umur: pasangan menikah berusia kurang dari 55 tahun dan menikah berusia lebih dari 55 tahun. Penilaian premi untuk pasangan menikah yang kurang dari 55 tahun diperoleh dengan metode Frasier dengan memperhitungkan probabilitas kematian setelah kematian terjadi dari salah satu tertanggung dengan asumsi kematian pasangan menikah adalah independen. Sedangkan untuk pasangan yang sudah menikah lebih dari 55 tahun, premi penilaian diperoleh dengan metode Frasier untuk menghitung probabilitas kematian dengan menganggap kematian pasangan menikah adalah dependen, asumsi ini dimodelkan oleh Frank kopula, dimana kopula ini adalah salah satu dari keluarga kopula Archimedes

  8. Poesia y Pintura: Frank O'Hara y el expresinionismo abstracto

    Directory of Open Access Journals (Sweden)

    Alberto Santamaría

    2015-07-01

    Full Text Available El objetivo de este artículo es analizar las relaciones entre poesía y pintura en el seno del expresionismo abstracto. Para ello tomamos tres nombres de referencia: Clement Greenberg (crítico de arte, Frank O'Hara (poeta y Willem De Kooning (pintor. A través de estos nombres tratamos de señalar la estrecha relación que existía entre poetas y pintores en la llamada Escuela de Nueva York.

  9. Popular Science and Apocalyptic Narrative in Frank Schätzing’s The Swarm

    OpenAIRE

    Gabriele Dürbeck

    2012-01-01

    Este trabajo analiza el uso de la retórica del Apocalipsis y el concepto de la venganza de la naturaleza en la novela de eco-suspense "El Quinto Día" de Frank Schätzing. Estudios realizados en ecocrítica han identificado estos patrones narrativos como característicos de la literatura medioambiental contemporánea. En "El Quinto Día", la retórica apocalíptica cumple una doble función: proporciona emoción y placer a los lectores y les advierte sobre el peligro ambiental inmine...

  10. E-business inom fastighetsbranschen : En undersökning av fastighetsbyrån Fantastic Franks differentiering genom E-business

    OpenAIRE

    2015-01-01

    Utifrån Canvas analysmodell, hur ser Fantastic Franks E-business ut? Hur är synen på E-business hos en liten nischad fastighetsbyrå? Syftet med denna studie är att analysera Fantastic Franks E-business genom Canvas analysmodell och analysera hur differentiering genom E-business påverkar företagets framgång. Genom intervju med ledningsgruppsrepresentant från Fantastic Frank samt med fastighetsmäklare på Fantastic Frank applicerades företagets affärsmodell på modellen Källor till värdeskapande ...

  11. O mundo de Ronald McDonald: sobre a marca publicitária e a socialidade midiática The world of Ronald McDonald: on the trademark and the mediatic sociality

    Directory of Open Access Journals (Sweden)

    Isleide Arruda Fontenelle

    2002-06-01

    Full Text Available O palhaço Ronald McDonald -- uma das imagens de marca da Corporação McDonald's -- é tomado como paradigma para pensarmos as relações entre mercado, mídia e entretenimento, as quais tem uma ligação direta com o que estamos conceituando como "socialidade midiática". Enquanto uma metáfora ideal de uma propaganda que parece não querer mais fazer sentido, a história do palhaço nos permite desvendar os sentidos contidos em duas das principais práticas do marketing moderno, a propaganda e a publicidade, revelando-nos como, entre o nonsense da propaganda contemporânea e uma publicidade que fundiu realidade e ilusão, há uma relação visceral entre mídia e publicidade, que estabelece uma nova forma de comunicação, na qual o sujeito torna-se apenas um meio para fins que ele sabe quais são, mas, paradoxalmente, age como se não soubesse. Tal paradoxo é revelador de uma forma de subjetividade profundamente marcada pela mídia enquanto agente socializador, na medida em que a atuação da mídia como mediador da socialidade contemporânea acabou por alterar o nosso universo perceptivo, saturando o nosso imaginário de uma forma radicalmente nova. Some-se a isso o fato de que a "socialidade midiática" implica uma nova forma de representação do sujeito no registro do "espetáculo", no sentido de que "estar na imagem é existir". Desnecessário dizer o quanto essas questões precisam ser contempladas pelos estudos contemporâneos sobre os processos de socialização e o quanto são desafiadoras para aqueles que atuam no universo da educação.The clown Ronald McDonald -- one of the trademarks of the McDonald's Corporation -- is taken as a paradigm to reflect upon the relations between market, media, and entertainment, which have a direct link with what we define as "mediatic sociality". As an ideal metaphor of an advertising that no longer seems to attempt to make sense, the story of the clown allows us to unveil the meanings contained

  12. ZACK SNYDER, FRANK MILLER AND HERODOTUS: THREE TAKES ON THE 300 SPARTANS

    Directory of Open Access Journals (Sweden)

    G.N. Murray

    2012-03-01

    Full Text Available The heroic defence of the Greeks at the battle of Thermopylae in 480 BC, in particularly the 300 Spartans who stood to the last man against the much larger Persian force, prompted comic book writer and illustrator Frank Miller to retell this story from a purely Spartan perspective. This version was retold once again when director Zack Snyder created a filmed version of the graphic novel named 300. Despite the film’s achievements at the box office, it was attacked for being, amongst others, historically incorrect and ideologically biased. In the graphic novel Frank Miller tells the tale of the battle at Thermopylae through the eyes of a Spartan warrior who bore the responsibility of spreading their tale so that the Spartans’ sacrifice might compel other Greek city-states to stand together against the Persians. Therefore the graphic novel and especially the film are drenched with Spartan superiority and Persian inferiority. Despite the inaccuracies and ideological bias, there are a few moments in the graphic novel and film that are notably historically correct.

  13. Interfactant-mediated quasi-Frank-van der Merwe growth of Pb on Si(111)

    Science.gov (United States)

    Schmidt, Th.; Bauer, E.

    2000-12-01

    The influence of interfactants (Au, Ag) on the growth of Pb on Si(111) is studied by low-energy electron microscopy in the temperature range from 260 K to 460 K. On the Si(111)-(7×7) surface Pb grows in the Stranski-Krastanov mode, on the Si(111)-(3×3)R30°-Au and on the Si(111)-(6×6)-Au surface in the quasi-Frank-van der Merwe (layer-by-layer) mode. On the Si(111)-(3×3)R30°-Ag surface the growth mode changes from layer-by-layer below 300 K to the Stranski-Krastanov mode above 300 K. The temperature dependence of the growth cannot be explained by thermodynamics but is governed by kinetics. The analysis of the maximum island density in terms of the atomistic nucleation theory gives acceptable values for nucleus size and energies only in the layer-by-layer growth regime. In the Stranski-Krastanov growth regime abnormal values are obtained that are attributed to high cluster mobility on the initial two-dimensional layer. The conditions leading to quasi-Frank-van der Merwe growth are discussed.

  14. Use of the Frank-Starling mechanism during submaximal versus maximal upright exercise.

    Science.gov (United States)

    Plotnick, G D; Becker, L C; Fisher, M L; Gerstenblith, G; Renlund, D G; Fleg, J L; Weisfeldt, M L; Lakatta, E G

    1986-12-01

    To evaluate the extent to which the Frank-Starling mechanism is utilized during successive stages of vigorous upright exercise, absolute left ventricular end-diastolic volume and ejection fraction were determined by gated blood pool scintigraphy at rest and during multilevel maximal upright bicycle exercise in 30 normal males aged 26-50 yr, who were able to exercise to 125 W or greater. Left ventricular end-systolic volume, stroke volume, and cardiac output were calculated at rest and during each successive 3-min stage of exercise [25, 50, 75, 100, and 125-225 W (peak)]. During early exercise (25 W), end-diastolic and stroke volumes increased (+17 +/- 1 and +31 +/- 4%, respectively), with no change in end-systolic volume. With further exercise (50-75 W) end-diastolic volume remained unchanged as end-systolic volume decreased (-12 +/- 4 and -24 + 5%, respectively). At peak exercise end-diastolic volume decreased to resting level, stroke volume remained at a plateau, and end-systolic volume further decreased (-48 +/- 7%). Thus the Frank-Starling mechanism is used early in exercise, perhaps because of a delay in sympathetic mobilization, and does not appear to play a role in the later stages of vigorous exercise.

  15. Extent of utilization of the Frank-Starling mechanism in conscious dogs. [preload effects on myocardial regulation

    Science.gov (United States)

    Boettcher, D. H.; Vatner, S. F.; Heyndrickx, G. R.; Braunwald, E.

    1978-01-01

    The left ventricular end-diastolic pressure-dimension relationships in conscious dogs were studied; the ventricle was stressed to its limit in terms of myocardial preload in order to assess the extent of use of the Frank-Starling mechanism under these conditions. The preload was increased through volume loading with saline infusions, the provocation of global myocardial ischemia by constriction of the left main coronary artery, and infusion of methoxamine. While left ventricular end-diastolic pressure increased substantially in the reclining conscious animals, the left ventricular end-diastolic diameter did not increase, suggesting a minimum role for the Frank-Starling mechanism in this case.

  16. A Man in the Depths of Meaning (Three S. Frank's Lectures Notes

    Directory of Open Access Journals (Sweden)

    Aliaev Gennadii

    2017-02-01

    Full Text Available he article represents three Simon Frank’s lecture notes, written in the 1920–30s — “The Meaning of Life”, ‘The Meaning of Love” and “The Meaning of Suff ering”, — which shed some more light on Simon Frank’s activity as a lecturer of Russian immigrant societies and organizations in the Western Europe. All these three lecture notes were designed to deal with moral issues, therefore it seems possible to assume that they were youth orientated and intended for the young audience. The topics of the lectures are central for the Frank’s mature period, his main works: the lecture notes refl ect the genesis process of a few ideas, which finally constituted Frank’s woks such as “The Meaning of Life,” “The Unknowable”, “God with Us”, and some others. However, there are also a number of original topics. For instance, “The Meaning of Love” contains a comparative analysis of two conceptions of love — Platonic and Freudian; “The Meaning of Suffering” purposes to solve the announced issue creating a typology of diverse national and cultural approaches to experience and comprehension of the suffering, as well as distinguishing two approaches within the framework of typically Russian attitude to suffering, which Frank calls “the way of Dostoevsky” and “the way of Pushkin”. Moreover, referring to bibliography we see that the texts represent Simon Frank as a reader, reflecting his literary interests for that period of his life. They demonstrate that Russian and German literature — the works of Tutchev, Boratynsky, Pushkin, Dostoevsky, Rilke — were important sources of Simon Frank’s inspiration. These texts reveal the Frank’s views on the topic of interrelations between Russia and Europe, which was one of the central topics of his works. In addition, “The Meaning of Suffering” provides us with a few important features to the portrait of Max Scheler as an intellectual who held the same views

  17. The Impact of the Dodd-Frank Act on Financial Stability and Economic Growth

    Directory of Open Access Journals (Sweden)

    Martin Neil Baily

    2017-01-01

    Full Text Available This article assesses the benefits and costs of key provisions of the Dodd-Frank Act that strengthened regulation following the financial crisis. The provisions are placed into five groupings: clear wins, clear losses, costly tradeoffs, unfinished business, and too soon to tell. Clear wins include higher prudential standards, including for capital; the single-point-of-entry resolution authority; creation of the Consumer Financial Protection Bureau; and greater transparency and oversight of derivatives. Clear losses are restrictions on Federal Reserve emergency lending authority and forcing the Federal Deposit Insurance Corporation to obtain permission from Congress before providing temporary liquidity guarantees. Costly tradeoffs are the Volcker Rule and the Lincoln Amendment. Unfinished business includes regulatory consolidation and more independence for the Financial Stability Oversight Council and the Office of Financial Research. Too soon to tell are requirements and standards for leverage ratios, capital buffers, stress testing, and liquidity requirements.

  18. MOBILE REMITTANCES AND DODD-FRANK: REVIEWING THE EFFECTS OF THE CFPB REGULATIONS

    Directory of Open Access Journals (Sweden)

    Colin C. Richard

    2012-04-01

    Full Text Available International remittances provide $325 billion in capital each year to developing countries and serve as an essential tool for international economic development. The growth of mobile money and mobile banking around the world will significantly increase access to remittance services and reduce costs for senders and recipients, but policy changes could irreparably deter the use of mobile phones for remittances. In July 2010, the Dodd-Frank Act proposed for the first time substantive federal regulation of international remittances and required the Consumer Financial Protection Bureau (CFPB to develop certain rules for the industry. This article analyzes the CFPB's February 2012 rule in the context of mobile remittances.

  19. Advancing astronomy on the American frontier: the career of Frank Herbert Loud

    Science.gov (United States)

    Ruskin, Steve

    2012-07-01

    Frank Herbert Loud came to Colorado Springs in 1877 to teach mathematics and became interested in astronomy after witnessing the solar eclipse of 1878. His nearly 50-year astronomical career included overseeing the building of two observatories, founding the Western Association for Stellar Photography, supporting expeditions for two solar eclipses, supplying astronomers with meteorological data for the Rocky Mountains, educating students, publishing astronomical articles and giving public lectures, and aiding and influencing two Directors of Harvard College Observatory. Despite this, Loud and the two observatories he directed have been mostly forgotten, although they were well known by contemporary astronomers. Loud and his work deserve to be remembered given the relative scarcity of astronomers and observatories in the American West (i.e. west of the Mississippi River) in the late nineteenth and early twentieth centuries.

  20. Reappraising Positivism and Education: The Arguments of Philipp Frank and Herbert Feigl

    Science.gov (United States)

    Matthews, Michaelr.

    This paper documents some of the `bad press' that Positivism has received in science education; it delineates the varied, and sometimes contradictory, ways in which educationalists characterize positivism; it indicates that Constructivism shares the same philosophical commitments as the instrumentalist tradition in positivism; and it suggests that there is considerable educational gain in reconsidering the philosophical and educational commitments of the non-instrumentalist, logical empiricist, tradition in positivism. The paper proceeds by examining and elaborating upon two educational papers of Vienna Circle members Philipp Frank and Herbert Feigl. It is argued that a number of the philosophical and educational `principles' of these foundational positivists are of value to educators facing a worldwide drift from natural sciences in schools and universities, and an increasingly strident anti-science lobby in universities and society. There are at least some positivist babies that should not be thrown out with the educational bathwater.

  1. Frank Chen 《Many Chinese companies can't explain what their brands signify》

    Institute of Scientific and Technical Information of China (English)

    WAN LIXIN

    2006-01-01

    @@ Frank Chen's brilliant academic credentials belie his soul, searching experience as a grassroots worker. The holder of PhD in Psychology from Beijing Normal University started out as a shop assistant, when he was sent to suburban Shanghai in the I97os as part of the national drive to re-educate urbanites through hard labor. Looking back, Chen finds this a cherished episode in his life that afforded him ample time to read and think. "I managed to read all the books I could lay my hands on. As there were so few of them, I read them repeatedly, with great care. Many books read differently the second time you read them." The politically charged atmosphere of that time also tended to endow people of his generations with a compelling sense of social responsibility. "This is important for my later career development," says Chen.

  2. An inevitable end? The collapse of the Lombard kingdom facing the Franks and the papacy

    Directory of Open Access Journals (Sweden)

    Stefano Gasparri

    2016-09-01

    Full Text Available According to the Italian historiography, from Alessandro Manzoni (1822 to the two major Italian historians who studied the Lombards at the middle of the twentieth century, Gian Piero Bognetti and Ottorino Bertolini, the Lombards remained always separated from the Roman population, of which the pope was the natural leader; the Lombards, too, became very late Catholics, in time, though, to experience the "drama" of having to fight against the pope, whose supreme spiritual authority the Lombards themselves at that point recognized. Consequently, the fall of the independent kingdom by the hands of the Franks would be logical and inevitable. This is an old and outdated position: the end of the independent Lombard kingdom wasn’t inevitable. At the time of the Frankish conquest, the kingdom was politically solid inward, in economic growth and very dynamic outward. During the reigns of Liutprand, Ratchis and Aistulf (712-757, the kingdom exercised its hegemony over the whole Italy. In this period no strong elements of internal weakness emerged. Therefore, the defeat of 774 was substantially caused by external factors, ie the alliance between the Franks and the papacy. However, the attitude of the popes against the Lombard kingdom was not always hostile. Things changed only with Stephen II, because of two simultaneous events occurring in 751: the royal anointing of Pepin in the Frankish kingdom and the conquest of the Exarchate by Aistulf. Italian political balance broke and caused the decisive rapprochement between Rome and the Franks. But there were still many uncertainties, as proved, for example, by Charlemagne’s marriage with a daughter of Desiderius. Carloman’s death in 771 and, the following year, the election of the new pope Adrian I caused the repudiation of the Lombard bride by Charlemagne, his descent into Italy in 773, and the capture of Pavia the year after: Desiderius was exiled in France and Charlemagne became rex Langobardorum. The

  3. Frank H. Netter, M.D. (1906-1991): the artist and his legacy.

    Science.gov (United States)

    Hansen, John T

    2006-09-01

    The renowned medical illustrator Frank H. Netter, M.D., was born on 25 April 1906 in Brooklyn, NY, and died on 17 September 1991 in New York, NY, at the age of 85. In his professional career, Dr. Netter painted over 4,000 medical illustrations, many of which became the center pieces of over 250 issues of Clinical Symposia and were compiled in the 13 volume set of The CIBA Collection of Medical Illustrations. Two years prior to his death, the Atlas of Human Anatomy was published, considered by many to be Dr. Netter's crowning achievement. The Atlas rapidly became the most widely used atlas of anatomy in American medical schools and currently is published in 16 languages. Netter's impressive career as an illustrator and his unique style and legacy to medical education are summarized briefly in this review.

  4. Mediations on Emergent Occasions: Mad Men, Donald Draper and Frank O’Hara

    Directory of Open Access Journals (Sweden)

    Kate Lilley

    2012-09-01

    Full Text Available Frank O’Hara’s 1957 poetry collection, Meditations in an Emergency, features in Season Two of Mad Men (2008 as a talismanic phrase and object. Pressed into service as Matthew Weiner’s valentine to his returning viewers, the circulation and citation of the book across the season, through different diegetic and extradiegetic levels, aligns poetry, advertising and quality serial television drama as textual modes intent, above all, on creating attachment through feeling. O’Hara’s book is a crucial link in a series of metonymic relays, chain effects and affects, which underwrite Mad Men’s citational poetics to assert its own cultural authority, and the mediating power of television.

  5. Modern housing design: prefabricated and modular design in Frank Lloyd Wright's architecture

    Directory of Open Access Journals (Sweden)

    Ana Tagliari

    2011-12-01

    Full Text Available This paper investigates the residential architecture of Frank Lloyd Wright, especially the designs which were conceived from an idea of prefabricated, modular, low-cost, and high-scale construction. Wright's organic designs originated from a material-based grid, which at the same time organized and provided freedom to create spaces and forms. This study reviews Wright's work, from his first Midwest designs that relied on brick, through an intermediary phase in California when he made intense use of concrete blocks, until his last phase, the usonian houses, which featured wood paneling. During his early career, the concept and the methodology of Wright's ideas greatly contributed to a better understanding of his architecture, his apprentices and his followers. The economy and rationalization found in the projects reviewed are of great importance as the analysis of historical proposals helps us understand the topic in question.

  6. Discovery of a Frank-Kasper sigma phase in sphere-forming block copolymer melts.

    Science.gov (United States)

    Lee, Sangwoo; Bluemle, Michael J; Bates, Frank S

    2010-10-15

    Sphere-forming block copolymers are known to self-assemble into body-centered cubic crystals near the order-disorder transition temperature. Small-angle x-ray scattering and transmission electron microscopy experiments on diblock and tetrablock copolymer melts have revealed an equilibrium phase characterized by a large tetragonal unit cell containing 30 microphase-separated spheres. This structure, referred to as the sigma (σ) phase by Frank and Kasper more than 50 years ago, nucleates and grows from the body-centered cubic phase similar to its occurrence in metal alloys and is a crystal approximant to dodecagonal quasicrystals. Formation of the σ phase in undiluted linear block copolymers (and certain branched dendrimers) appears to be mediated by macromolecular packing frustration, an entropic contribution to the interparticle interactions that control the sphere-packing geometry.

  7. Role of the giant elastic protein titin in the Frank-Starling mechanism of the heart.

    Science.gov (United States)

    Fukuda, Norio; Granzier, Henk

    2004-04-01

    Increased ventricular volume enhances the systolic performance, a phenomenon known as Frank-Starling's law of the heart. At its basis is the ability of cardiac muscle to produce increased active force in response to increased muscle length. Although numerous studies have been conducted to elucidate the molecular basis of length-dependent activation, the mechanism remains elusive. The giant protein titin (also known as connectin) is the third filament system in the sarcomere and is responsible for most passive stiffness of striated muscle in the physiological sarcomere length range. The force generated by titin is usually seen as passive and independent of active force generation. Recent findings, however, suggest that titin-based passive force modulates actin-myosin interaction, resulting in greater active force in response to stretch. In this short review, we discuss the molecular mechanisms of length-dependent activation, focusing on the possible role of titin in its regulation.

  8. Spatial History e humanidades digitais, uma entrevista com o brasilianista Zephyr Frank

    Directory of Open Access Journals (Sweden)

    FREDERICO FREITAS

    2014-04-01

    Full Text Available Resumo: Entrevista com Zephyr Frank, diretor do Spatial History Project (Projeto de História Espacial e do Center for Spatial and Textual Analysis (Centro de Análise Espacial e Textual da Universidade Stanford, nos Estados Unidos, sobre spatial history e outras linhas de pesquisa englobadas sob o rótulo das humanidades digitais. A discussão toca o tema do uso de novos métodos digitais como o SIG histórico, a leitura à distância e a análise de redes sociais na pesquisa em humanidades, questionando os limites e as possibilidades de tais ferramentas. Por fim, discute-se sobre o investimento institucional e financeiro necessário para a implementação dessas novas tecnologias de pesquisa.Palavras-chave: Spatial History – Humanidades Digitais – Redes Sociais – Leitura à Distância. Abstract: An interview with Zephyr Frank, director of both the Spatial History Project and the Center for Spatial and Textual Analysis at Stanford University, on spatial history and other lines of research encompassed by the digital humanities label. The discussion touches on the new digital methods of research like historical GIS, distant reading, and social network analysis, which are becoming more common among humanists. It also questions the possibilities and limits of such tools. Finally, it presents a brief discussion on the institutional and financial resources needed for implementing those new research technologies.Keywords: Spatial History – Digital Humanities – Social Networks – Distant Reading.

  9. Exhaustion of Frank-Starling mechanism in conscious dogs with heart failure.

    Science.gov (United States)

    Komamura, K; Shannon, R P; Ihara, T; Shen, Y T; Mirsky, I; Bishop, S P; Vatner, S F

    1993-10-01

    The goal of this study was to elucidate the ability of the left ventricle to accommodate an increase in preload (Frank-Starling mechanism) in the presence of congestive heart failure (CHF) but in the absence of the complicating effects of hypertrophy and fibrosis. To accomplish this, the effects of volume loading were examined in eight conscious dogs during the control state and after 3 wk of right ventricular pacing (240 beats/min). CHF increased heart rate (by 16 +/- 5 from 92 +/- 5 beats/min), left ventricular (LV) end-diastolic pressure (by 17 +/- 2 from 10 +/- 1 mmHg), and LV end-diastolic volume (EDV; by 23 +/- 4 from 57 +/- 3 ml). Despite reduced LV ejection fraction (from 54 +/- 3 to 31 +/- 3%), there was no significant change in cardiac output (2.5 +/- 0.3 l/min) compared with control (2.7 +/- 0.2 l/min). Stroke volume was preserved (control 19 +/- 2 ml; CHF 18 +/- 2 ml) at a constant heart rate by a shift to the right in the relationship between LV stroke volume and EDV, indicating the importance of chronic ventricular dilatation in maintaining pump performance. In the control state, acute volume load increased LV EDV (by 17 +/- 2 ml) and stroke volume (by 11 +/- 2 ml), whereas in CHF it did not increase LV EDV or stroke volume. Scanning electron microscopy revealed areas of reduced collagen weave pattern surrounding myofibers. Myocyte cross-sectional area by transmission electron microscopy was significantly reduced, and there were multiple electron-dense expansions of the Z lines with disruption of the normal lateral sarcomere alignment. These morphological findings suggest that chronic ventricular dilatation utilized in CHF results from myocyte stretch and morphological intracellular rearrangement. Furthermore, the failing heart cannot further augment stroke volume by acutely increasing EDV in CHF, suggesting that the Frank-Starling reserve is essentially exhausted.

  10. The use of precedents in Brazil and the new Code of Civil Procedure: analysis in the perspective of "law as integrity" of Ronald Dworkin

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    Anna Flávia Magalhães de Caux Barros

    2015-06-01

    Full Text Available This article analyses the judicial precedents and the principle of integrity in the Brazilian legal system. First, an overview of the conception of “law as integrity” elaborated by Ronald Dworkin is outlined. Then, it is made an analysis of the subject in Brazil, pointing aspects that confirm the recently appreciation of the precedents in that country. Subsequently, it is made a critical of the way in which precedents are used in Brazil. Finally, it is studied the question in the New Code of Civil Procedure particularly by using the new law as well as some doctrine about the matter.

  11. 76 FR 48949 - Office of Thrift Supervision Integration Pursuant to the Dodd-Frank Wall Street Reform and...

    Science.gov (United States)

    2011-08-09

    ... accounts from the HOLA. Section 157.14 provided that savings associations could pay interest only on.... Section 1046 of the Dodd-Frank Act provides that the Home Owners' Loan Act (HOLA) does not occupy the... a court or by the OCC under the HOLA with respect to Federal savings associations must be made...

  12. Inquiry, Evidence, and Excellence: The Promise and Practice of Quality Assurance. A Festschrift in Honor of Frank B. Murray

    Science.gov (United States)

    LaCelle-Peterson, Mark, Ed.; Rigden, Diana, Ed.

    2012-01-01

    The overall aim of this volume of essays is to honor Frank B. Murray's commitments to empirically-based quality assurance and to the development of increasingly effective systems of quality control in educator preparation programs. As the editors approached the authors with the invitation to contribute an essay, two characteristic aspects of…

  13. 78 FR 1306 - Transition Period Under Section 716 of the Dodd-Frank Wall Street Reform and Consumer Protection Act

    Science.gov (United States)

    2013-01-08

    ... dealers as swap dealers. \\4\\ Guidance on the Effective Date of Section 716, 77 FR 27465 (May 10, 2012... deems necessary and appropriate.\\12\\ \\11\\ See Further Definition of Swap Dealer, 77 FR 30595 (May 23... Office of the Comptroller of the Currency Transition Period Under Section 716 of the Dodd-Frank...

  14. Vectorcardiogram of complete right bundle branch block with left axis deviation by the Frank and Kimura systems.

    Directory of Open Access Journals (Sweden)

    Nakagawa,Masahiro

    1979-10-01

    Full Text Available Vectorcardiogram (VCG recorded by both the Frank and Kimura systems were examined in 45 patients with complete right bundle branch block (RBBB and left axis deviation (LAD to investigate the relationship seen on electrocardiogram (ECG between RBBB with LAD and bilateral bundle. The sample included: 13 cases of type SI, SII, SIII, SaVF; 21 cases of type SI, SII, SIII, aVF; and 11 cases of types SI, SII, SIII. VCG recorded by the Frank system were classified into seven types according to the QRS loop pattern on the frontal plane and into three types according to the horizontal plane. The main findings were: (a In the Frank system the QRS loop in the frontal plane showed a variety of patterns in RBBB with LAD. (b On VCG of complete RBBB judged complicated by a left anterior hemiblock by the Frank system, the main portion of the QRS loop extended to the left superior or merely to the left in the frontal plane. The direction of rotation and position on the horizontal plane were not consistent. (c The results of this study suggest the usefulness of the Kimura system as an auxiliary diagnostic technique.

  15. Bodies in Space/Bodies in Motion/Bodies in Character: Adolescents Bear Witness to Anne Frank

    Science.gov (United States)

    Chisholm, James S.; Whitmore, Kathryn F.

    2016-01-01

    Situated at the intersection of research on Holocaust education and embodied literacies this study examines how an arts-based instructional approach engaged middle school learners in developing empathetic perspectives on the Anne Frank narrative. We addressed the research question: What can adolescents who are using their bodies to gain empathy…

  16. 78 FR 45288 - Frank Sherman, Evergreen Trails, Inc., Cabana Coaches, LLC, TMS West Coast, Inc. and FSCS...

    Science.gov (United States)

    2013-07-26

    ... Surface Transportation Board Frank Sherman, Evergreen Trails, Inc., Cabana Coaches, LLC, TMS West Coast... Trails, Inc. (Evergreen), Cabana Coaches, LLC (Cabana), TMS West Coast, Inc. (TMS), and FSCS Corporation... shareholder of noncarrier holding companies FSCS and TMS. Cabana is owned directly by FSCS and Evergreen...

  17. 76 FR 54374 - Disclosure for Asset-Backed Securities Required by Section 943 of the Dodd-Frank Wall Street...

    Science.gov (United States)

    2011-09-01

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION 17 CFR PART 240 RIN 3235-AK75 Disclosure for Asset-Backed Securities Required by Section 943 of the Dodd-Frank Wall Street Reform and Consumer Protection Act AGENCY: Securities and Exchange...

  18. The Professor and the Student, Sir Ronald Aylmer Fisher (1890-1962) and William Sealy Gosset (1876-1937): Careers of two giants in mathematical statistics.

    Science.gov (United States)

    Vyas, Shreena A; Desai, Sukumar P

    2015-05-01

    Sir Ronald Aylmer Fisher and William Sealy Gosset were responsible for laying the foundations of statistical inference. Tests that bear their names are used by students and researchers in a wide variety of scientific disciplines. Similar and different in many respects, their lives and careers are the subject of this essay. They were not teacher and pupil; in fact the student was 14 years older than the professor. Their careers did not require them to interact with one another much but they were aware of one another's work. Although Sir Ronald is assigned the role of the professor, his success as a teacher was impaired by his inability to understand the limitations of his students. Meanwhile Gosset was forced to publish his work under the pseudonym 'Student' in order to make contributions to the field of mathematical statistics. Both men are undisputed giants in the field of statistics and we celebrate their achievements as much as we try to understand their struggles. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  19. La igualdad de recursos de Ronald Dworkin: ¿una concepción fallida? | Dworkin’s Equality of Resources, a failed account?

    Directory of Open Access Journals (Sweden)

    Jahel Queralt Lange

    2014-12-01

    Full Text Available Resumen: Este artículo analiza la igualdad de recursos planteada por Ronald Dworkin. Sostiene que la propuesta es exitosa a la hora de mostrar que, bien entendida, la responsabilidad individual justifica un estado del bienestar más generoso que los que tenemos pero que no consigue identificar adecuadamente instituciones que la satisfagan adecuadamente. Dworkin no resuelve bien las objeciones que cuestionan la capacidad de su propuesta para generar resultados que sean fieles a la intuición que la motiva. Su respuesta hace depender el éxito de la implementación de su teoría de circunstancias que pueden no darse en la realidad. Abstract: This article examines Ronald Dworkin’s equality of resources. It claims that his proposal is successful in showing that, rightly understood, individual responsibility justifies a generous welfare state. He fails, however, in identifying the institutions capable of satisfying its principles. Dworkin does not address correctly the objections that question the capacity of his account to generate distributive outcomes that are responsibility-sensitive and circumstance-insensitive. His answer makes the success of the implementation of his account dependent on circumstances that are contingent and, hence, might not obtain in our societies.

  20. Counting on Frank: Using bibliotherapy in mathematics teaching to prevent de-geniusing

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    Joseph M. Furner

    2011-11-01

    Full Text Available Today the understanding of mathematics is critical in an increasingly technological age. Teachers must play an important role to ensure that all students display confidence in their ability to do mathematics. Often gifted students of mathematics can be made to feel bad by their peers just because they know mathematics and things come easily to them. Children’s and adolescent literature has now been recognised as a means of teaching mathematics to students through the use of stories to make the mathematics concepts relevant and meaningful. Literature can also be used as a form of therapy to reach students who may be frustrated with children picking on them for being good at mathematics. Story and picture books such as Counting on Frank, Math Curse and A Gebra Named Al are now available to use in the classroom as forms of bibliotherapy in helping students come to terms with issues relating to mathematics that haunt them. In this article we discuss the phenomenon of dumbing down by the gifted population to fit in with their peers. We propose using reading and discussion (bibliotherapy to aid in preventing de-geniusing of mathematically gifted students.

  1. Holy Terror, Batman! Frank Miller’s Dark Knight and the Superhero as Hardboiled Terrorist

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    Daniele Croci

    2016-05-01

    Full Text Available Conceived in the late thirties as “bold humanist response to Depression-era fears of runaway scientific advance and soulless industrialism” (Morrison 2012, 6, the superhero has flourished as one of the most resilient archetypes of American popular culture. This essay analyses the literary and cultural contaminations that have engendered an unprecedented revision of the paradigm since the 1980s. In particular, it will take into account three graphic novels by American cartoonist Frank Miller (1957 - , one of leading figures of the mainstream comics renaissance, whose ideas have indelibly influenced the artistic development of both medium and genre. The Dark Knight Returns (1986, The Dark Knight Strikes Again (2002 and Holy Terror (2011 constitute an ideal Batman trilogy that charts the character’s evolution as political counterpoint to the perceived crisis of American identity. In this regard, Reaganism and 9/11 are polarized as historical discontinuities triggering the need for a new kind of a criminal (superhero. It will be in fact demonstrated how the novels hybridise the latent generic links to hardboiled pulp novels (R. Chandler, D. Hammet with narrative and aesthetics elements appropriated from the culturally-received concepts of terrorism and terrorists. This fruitful contamination on the one hand “play[s] with reader assumptions about genre” (Baetens and Frey 2015, 46, while on the other hand deconstructs the ideological underpinnings of the archetype, as the moral dichotomy and the alienation of justice from the law.

  2. “The root of all evil”: Frank McGuinness’ Translations of Greek Drama

    Directory of Open Access Journals (Sweden)

    Loredana Salis

    2014-07-01

    Full Text Available Whether in political propaganda or in creative the myths of ancient Greece have long attracted scholars, writers and audiences from Ireland. Over the past forty years, a wealth of adaptations of plays by Sophocles and Euripides have been produced, which bring back to life ancient tales of heroes and heroines, in settings at times distinctively local and contemporary, at times deliberately universal. Field Day’s contributions represent a typical instance of the former approach to the classics, while other Irish playwrights have used Greek myths to reflect upon questions that are not exclusively Irish. Their plays may have an Irish echo, and some are even set in Ireland, but their main preoccupation lies beyond geographical borders. Frank McGuinness belongs to this second group of playwrights. To date, he has reworked and staged five Greek plays with great audience and critical acclaim. This paper locates his translations of Sophocles and Euripides within the tradition of classical tragedy use in Ireland at the crossroads between the local and the global and at the search of what he calls ‘the root of all evil’ with special attention to his Oedipus (2008 and Helen (2009.

  3. An analysis of key characteristics of the Frank-Read source process in FCC metals

    Science.gov (United States)

    Xu, Shuozhi; Xiong, Liming; Chen, Youping; McDowell, David L.

    2016-11-01

    A well-known intragranular dislocation source, the Frank-Read (FR) source plays an important role in size-dependent dislocation multiplication in crystalline materials. Despite a number of studies in this topic, a systematic investigation of multiple aspects of the FR source in different materials is lacking. In this paper, we employ large scale quasistatic concurrent atomistic-continuum (CAC) simulations to model an edge dislocation bowing out from an FR source in Cu, Ni, and Al. First, a number of quantities that are important for the FR source process are quantified in the coarse-grained domain. Then, two key characteristics of the FR source, including the critical shear stress and critical dislocation configuration, are investigated. In all crystalline materials, the critical stresses and the aspect ratio of the dislocation half-loop height to the FR source length scale well with respect to the FR source length. In Al, the critical stress calculated by CAC simulations for a given FR source length agrees reasonably well with a continuum model that explicitly includes the dislocation core energy. Nevertheless, the predictions of the isotropic elastic theory do not accurately capture the FR source responses in Cu and Ni, which have a relatively large stacking fault width and elastic anisotropy. Our results highlight the significance of directly simulating the FR source activities using fully 3D models and shed light on developing more accurate continuum models.

  4. A tribute to Dr.Frank I Tovey on his 90th birthday

    Institute of Scientific and Technical Information of China (English)

    Lian-Sheng Ma

    2011-01-01

    This paper pays a tribute to Dr. Frank I Tovey on his 90th birthday which happens on September 1, 2011, and briefly describes the major findings in his research career and contributions as follows. The geographical prevalence of duodenal ulceration is related to staple diets. Unrefined wheat and maize, soya, certain pulses and millets are associated with a low prevalence while refined wheat, maize and rice, yams, cassava and green banana with a high prevalence. Predominant foodstuffs from low prevalence areas are ulceroprotective in rat peptic ulcer models. The protective activity lies in the lipid fraction present in these foodstuffs. The lipid fraction also promotes ulcer healing, is active both orally and intramuscularly and is ulceroprotective against non-steroidal anti-inflammatory drugs (NSAIDs). The phospholipids and phytosterols present in the lipid have been identified to be responsible for this protective activity. The combination of phospholipids and phytosterols may be of value in the prevention and treatment of duodenal ulceration and protection against the ulcerogenic effect of NSAIDs.

  5. On the Connection between Kinetic Monte Carlo and the Burton-Cabrera-Frank Theory

    Science.gov (United States)

    Patrone, Paul; Margetis, Dionisios; Einstein, T. L.

    2013-03-01

    In the many years since it was first proposed, the Burton- Cabrera-Frank (BCF) model of step-flow has been experimentally established as one of the cornerstones of surface physics. However, many questions remain regarding the underlying physical processes and theoretical assumptions that give rise to the BCF theory. In this work, we formally derive the BCF theory from an atomistic, kinetic Monte Carlo model of the surface in 1 +1 dimensions with one step. Our analysis (i) shows how the BCF theory describes a surface with a low density of adsorbed atoms, and (ii) establishes a set of near-equilibrium conditions ensuring that the theory remains valid for all times. Support for PP was provided by the NIST-ARRA Fellowship Award No. 70NANB10H026 through UMD. Support for TLE and PP was also provided by the CMTC at UMD, with ancillary support from the UMD MRSEC. Support for DM was provided by NSF DMS0847587 at UMD.

  6. The Anne Frank Haven: A case of an alternative educational program in an integrative Kibbutz setting

    Science.gov (United States)

    Ben-Peretz, Miriam; Giladi, Moshe; Dror, Yuval

    1992-01-01

    The essential features of the programme of the Anne Frank Haven are the complete integration of children from low SES and different cultural backgrounds with Kibbutz children; a holistic approach to education; and the involvement of the whole community in an "open" residential school. After 33 years, it is argued that the experiment has proved successful in absorbing city-born youth in the Kibbutz, enabling at-risk populations to reach significant academic achievements, and ensuring their continued participation in the dominant culture. The basic integration model consists of "layers" of concentric circles, in dynamic interaction. The innermost circle is the class, the learning community. The Kibbutz community and the foster parents form a supportive, enveloping circle, which enables students to become part of the outer community and to intervene in it. A kind of meta-environment, the inter-Kibbutz partnership and the Israeli educational system, influence the program through decision making and guidance. Some of the principles of the Haven — integration, community involvement, a year's induction for all new students, and open residential settings — could be useful for cultures and societies outside the Kibbutz. The real "secret" of success of an alternative educational program is the dedicated, motivated and highly trained staff.

  7. Risk, uncertainty and prophet: The psychological insights of Frank H. Knight

    Directory of Open Access Journals (Sweden)

    Tim Rakow

    2010-10-01

    Full Text Available Economist Frank H. Knight (1885--1972 is commonly credited with defining the distinction between decisions under ``risk'' (known chance and decisions under ``uncertainty'' (unmeasurable probability in his 1921 book Risk, Uncertainty and Profit. A closer reading of Knight (1921 reveals a host of psychological insights beyond this risk-uncertainty distinction, many of which foreshadow revolutionary advances in psychological decision theory from the latter half of the 20th century. Knight's description of economic decision making shared much with Simon's (1955, 1956 notion of bounded rationality, whereby choice behavior is regulated by cognitive and environmental constraints. Knight described features of risky choice that were to become key components of prospect theory (Kahneman and Tversky, 1979: the reference dependent valuation of outcomes, and the non-linear weighting of probabilities. Knight also discussed several biases in human decision making, and pointed to two systems of reasoning: one quick, intuitive but error prone, and a slower, more deliberate, rule-based system. A discussion of Knight's potential contribution to psychological decision theory emphasises the importance of a historical perspective on theory development, and the potential value of sourcing ideas from other disciplines or from earlier periods of time.

  8. Research of Helium Isotopes in Taiwan: The Legacy of Dr. Tsanyao Frank Yang

    Science.gov (United States)

    Yang, Tsanyao Frank; Lan, Tefang; Lee, Hsiao-Fen; Fu, Ching-Chou; Chuang, Pei-Chuan; Hong, Wei-Li; Walia, Vivek; Chen, Hsuan-Wen; Wen, Hsin-Yi; Chen, Ai-Ti; Chen, Hsiao-Chi; Chiu, Chun-Ming; Cheng, Chun-Yuan; Wu, Nian-Ru; Cheng, Yu-Chen; Chuang, Jin-Lun; Kao, Li-Hsin; Chen, Cheng-Hong; Sano, Yuji

    2016-04-01

    Helium isotope systematics is a powerful proxy to distinguish fluid origins and conveys fruitful geological information. In the past several decades, this robust isotope systematics had offered pivotal knowledge on many key issues in Earth and planetary sciences. It revealed essential geological information of Taiwan as well. Taiwan is located on the junction of two subduction systems-Ryukyu Arc and Luzon Arc. The geotectonic setting is complex and intriguing. Dr. Tsanyao Frank Yang was the pioneer of gas geochemistry studies in Taiwan. He established the first gas geochemistry laboratory in National Taiwan University in 1998 and started exploring all possible research topics on and around this tectonic-active island. In the past two decades, his research covered volcanic/hydrothermal gas studies, volcanic activity monitoring, gas hydrate exploration, soil gas as a tool to locate fault traces, soil gas flux measurement, earthquake precursory, mud volcanoes, low-temperature geochronology and many more. He died of pancreas cancer in March 2015. He was a warm and enthusiastic mentor, a prolific scientist and a great friend. He will always be remembered. Here we present Dr. Yang's achievement on helium isotopes studies in Taiwan throughout his research career. We integrate all the research results from his team and summarize the observations. We will show the distribution of helium isotope ratios in Taiwan and its implications on tectonic settings.

  9. Cellular mechanisms for the slow phase of the Frank-Starling response.

    Science.gov (United States)

    Bluhm, W F; Sung, D; Lew, W Y; Garfinkel, A; McCulloch, A D

    1998-01-01

    Following a step increase in sarcomere length, isometric cardiac muscle tension increases instantaneously by the Frank-Starling mechanism. In isolated papillary muscle and myocytes, there is an additional significant rise in developed tension over the following 15 min due to an unknown mechanism. This slow change in tension could not be explained by mechanical heterogeneity of the muscle preparations or by an increase in myofilament sensitivity to Ca2+. The slow change in tension was not dependent on sarcoplasmic reticulum Ca2+ loading assessed with rapid cooling contractures, and was not significantly altered by sarcoplasmic reticulum Ca2+ depletion (ryanodine) or inhibition of sarcoplasmic reticulum Ca2+ reuptake (cyclopiazonic acid). We used the Luo-Rudy ionic model of the ventricular myocyte together with a model of the length-dependent myofilament activation by Ca2+ to examine the effects of step changes in the parameters of sarcolemmal ion fluxes as possible mechanisms for the slow change in stress. The slow increase in tension was simulated by step changes in the Na+-K+ pump or Na+ leak currents, suggesting that the slow change in stress may be caused by length induced changes in Na+ fluxes. The model also predicted a slow increase in the magnitude of the initial repolarization during phase 1 of the action potential. The combination of experimental and computational models used in this investigation represents a valuable technique in elucidating the cellular mechanisms of fundamental processes in cardiac excitation-contraction coupling.

  10. Myosin head orientation: a structural determinant for the Frank-Starling relationship.

    Science.gov (United States)

    Farman, Gerrie P; Gore, David; Allen, Edward; Schoenfelt, Kelly; Irving, Thomas C; de Tombe, Pieter P

    2011-06-01

    The cellular mechanism underlying the Frank-Starling law of the heart is myofilament length-dependent activation. The mechanism(s) whereby sarcomeres detect changes in length and translate this into increased sensitivity to activating calcium has been elusive. Small-angle X-ray diffraction studies have revealed that the intact myofilament lattice undergoes numerous structural changes upon an increase in sarcomere length (SL): lattice spacing and the I(1,1)/I(1,0) intensity ratio decreases, whereas the M3 meridional reflection intensity (I(M3)) increases, concomitant with increases in diastolic and systolic force. Using a short (∼10 ms) X-ray exposure just before electrical stimulation, we were able to obtain detailed structural information regarding the effects of external osmotic compression (with mannitol) and obtain SL on thin intact electrically stimulated isolated rat right ventricular trabeculae. We show that over the same incremental increases in SL, the relative changes in systolic force track more closely to the relative changes in myosin head orientation (as reported by I(M3)) than to the relative changes in lattice spacing. We conclude that myosin head orientation before activation determines myocardial sarcomere activation levels and that this may be the dominant mechanism for length-dependent activation.

  11. Role of the Frank-Starling mechanism during maximal semisupine exercise after oral atenolol.

    Science.gov (United States)

    Andersen, K; Vik-Mo, H

    1982-08-01

    Reproducible left ventricular dimensions were found by M-mode echocardiography in eight healthy men in the semisupine position during two maximal bicycle exercise tests, performed with four hours interval. Left ventricular end-diastolic dimension did not increase during maximal exercise, while fractional shortening increased by a decrease in end-systolic dimension. Twelve men studied by the same procedure were given 100 mg atenolol orally just after the first test which conspicuously reduced their heart rate response to exercise. End-diastolic dimension increased significantly from rest to peak exercise after the administration of atenolol in contrast to that before beta blockade, and fractional shortening at maximal exercise increased compared with the preceding control test. We conclude that atenolol changes the left ventricular response to maximal semisupine exercise in normal man, with dilatation and a concomitant increase in systolic myocardial shortening. This suggests that atenolol during maximal exercise reveals the part played by the Frank-Starling mechanism in cardiac reserve. In addition to that mechanism, the increased ventricular emptying is probably also the result of reduced afterload after administration of atenolol.

  12. Titin/connectin-based modulation of the Frank-Starling mechanism of the heart.

    Science.gov (United States)

    Fukuda, Norio; Granzier, Henk L

    2005-01-01

    The basis of the Frank-Starling mechanism of the heart is the increase in active force when muscle is stretched. Various findings have shown that muscle length, i.e., sarcomere length (SL), modulates activation of cardiac myofilaments at a given concentration of Ca2+ ([Ca2+]). This augmented Ca2+ activation with SL, commonly known as "length-dependent activation", is manifested as the leftward shift of the force-pCa (= -log [Ca2+]) relation as well as by the increase in maximal Ca2+ -activated force. Despite the numerous studies that have been undertaken, the molecular mechanism(s) of length-dependent activation is (are) still not fully understood. The giant sarcomere protein titin/connectin is the largest protein known to date. Titin/connectin is responsible for most passive force in vertebrate striated muscle and also functions as a molecular scaffold during myofibrillogenesis. Recent studies suggest that titin/connectin plays an important role in length-dependent activation by sensing stretch and promoting actomyosin interaction. Here we review and extend this previous work and focus on the mechanism by which titin/connectin might modulate actomyosin interaction.

  13. Cardiac system bioenergetics: metabolic basis of the Frank-Starling law.

    Science.gov (United States)

    Saks, Valdur; Dzeja, Petras; Schlattner, Uwe; Vendelin, Marko; Terzic, Andre; Wallimann, Theo

    2006-03-01

    The fundamental principle of cardiac behaviour is described by the Frank-Starling law relating force of contraction during systole with end-diastolic volume. While both work and respiration rates increase linearly with imposed load, the basis of mechano-energetic coupling in heart muscle has remained a long-standing enigma. Here, we highlight advances made in understanding of complex cellular and molecular mechanisms that orchestrate coupling of mitochondrial oxidative phosphorylation with ATP utilization for muscle contraction. Cardiac system bioenergetics critically depends on an interrelated metabolic infrastructure regulating mitochondrial respiration and energy fluxes throughout cellular compartments. The data reviewed indicate the significance of two interrelated systems regulating mitochondrial respiration and energy fluxes in cells: (1) the creatine kinase, adenylate kinase and glycolytic pathways that communicate flux changes generated by cellular ATPases within structurally organized enzymatic modules and networks; and (2) a secondary system based on mitochondrial participation in cellular calcium cycle, which adjusts substrate oxidation and energy-transducing processes to meet increasing cellular energy demands. By conveying energetic signals to metabolic sensors, coupled phosphotransfer reactions provide a high-fidelity regulation of the excitation-contraction cycle. Such integration of energetics with calcium signalling systems provides the basis for 'metabolic pacing', synchronizing the cellular electrical and mechanical activities with energy supply processes.

  14. Myosin head orientation: a structural determinant for the Frank-Starling relationship

    Energy Technology Data Exchange (ETDEWEB)

    Farman, Gerrie P.; Gore, David; Allen, Edward; Schoenfelt, Kelly; Irving, Thomas C.; de Tombe, Pieter P. (IIT); (UIC)

    2011-09-06

    The cellular mechanism underlying the Frank-Starling law of the heart is myofilament length-dependent activation. The mechanism(s) whereby sarcomeres detect changes in length and translate this into increased sensitivity to activating calcium has been elusive. Small-angle X-ray diffraction studies have revealed that the intact myofilament lattice undergoes numerous structural changes upon an increase in sarcomere length (SL): lattice spacing and the I{sub 1,1}/I{sub 1,0} intensity ratio decreases, whereas the M3 meridional reflection intensity (I{sub M3}) increases, concomitant with increases in diastolic and systolic force. Using a short ({approx}10 ms) X-ray exposure just before electrical stimulation, we were able to obtain detailed structural information regarding the effects of external osmotic compression (with mannitol) and obtain SL on thin intact electrically stimulated isolated rat right ventricular trabeculae. We show that over the same incremental increases in SL, the relative changes in systolic force track more closely to the relative changes in myosin head orientation (as reported by IM3) than to the relative changes in lattice spacing. We conclude that myosin head orientation before activation determines myocardial sarcomere activation levels and that this may be the dominant mechanism for length-dependent activation.

  15. Titin and troponin: central players in the frank-starling mechanism of the heart.

    Science.gov (United States)

    Fukuda, Norio; Terui, Takako; Ohtsuki, Iwao; Ishiwata, Shin'ichi; Kurihara, Satoshi

    2009-05-01

    The basis of the Frank-Starling mechanism of the heart is the intrinsic ability of cardiac muscle to produce greater active force in response to stretch, a phenomenon known as length-dependent activation. A feedback mechanism transmitted from cross-bridge formation to troponin C to enhance Ca(2+) binding has long been proposed to account for length-dependent activation. However, recent advances in muscle physiology research technologies have enabled the identification of other factors involved in length-dependent activation. The striated muscle sarcomere contains a third filament system composed of the giant elastic protein titin, which is responsible for most passive stiffness in the physiological sarcomere length range. Recent studies have revealed a significant coupling of active and passive forces in cardiac muscle, where titin-based passive force promotes cross-bridge recruitment, resulting in greater active force production in response to stretch. More currently, the focus has been placed on the troponin-based "on-off" switching of the thin filament state in the regulation of length-dependent activation. In this review, we discuss how myocardial length-dependent activation is coordinately regulated by sarcomere proteins.

  16. Wi-Fi联盟最新进展报告-访Wi-Fi联盟总经理Frank Hanzlik

    Institute of Scientific and Technical Information of China (English)

    高威

    2006-01-01

    @@ 06年1月20日,Wi-Fi联盟董事总经理FrankHanzlik先生来华进行访问.据称,Frank此次来华的目的在于访问Wi-Fi在北京的实验室,与联盟成员进行进一步的沟通,并且拜访一些将来可能加入Wi-Fi联盟的成员.

  17. Recovery of the Frank-Starling mechanism by coenzyme Q10 in patients with load-induced contractility depression.

    Science.gov (United States)

    Oda, T

    1993-01-01

    Load-induced contractility depression, in which supernormal left ventricular ejection fraction and contractility at rest decrease by added afterload, is most often found in children with mitral valve prolapse who have symptoms. Patients have high ventricular end-diastolic pressure at rest, which is further increased by afterload challenge. The Frank-Starling mechanism may be maximally mobilized with high preload even at rest to compensate for the intrinsically depressed inotropic state. Therefore, preload reserve may be easily exhausted due to afterload addition. We aimed to determine left ventricular end-diastolic fiber length, stroke work, and contractility before and during handgrip by echocardiograms to obtain evidence for the Frank-Starling mechanism in patients and controls, including patients treated with coenzyme Q10. The subjects were divided into four groups, each consisting of 30 children aged 6-16 years: group 1, normals; group 2, patients; group 3, the same patients as in group 2 after coenzyme Q10 therapy; and group 4, patients with asymptomatic mitral valve prolapse. Baseline values and percentage increases in systolic blood pressure, heart rate, and left ventricular wall stress showed no differences among the groups. Only in group 2 were the percentage increase in ejection fraction, fiber shortening velocity, contractility, and end-diastolic dimension strongly negative, despite supernormal baseline levels. In other groups, these were significantly positive, without intergroup differences. We conclude that in the heart with load-induced contractility depression, the Frank-Starling mechanism deviates from normal. The normal Frank-Starling mechanism was recovered due to coenzyme Q10, which may improve disturbed bioenergetic function at the molecular level.

  18. A CASE OF FRANK INTRABILIARY RUPTURE OF HEPATIC HYDATID CYST VIA FISTULA TO THE COMMON BILE DUCT

    Directory of Open Access Journals (Sweden)

    Rahele Mehraeen

    2012-05-01

    Full Text Available Hydatid disease primarily affects the liver and typically demonstrates characteristic imaging findings.There are many potential local complications as intrahepatic complications, exophytic growth, transdiaphragmatic thoracic involvement, perforation into hollow viscera, peritoneal seeding, biliary communication, portal vein involvement and abdominal wall invasion. Rupture of a hydatid cyst into the biliary tract is the most common complication of hepatic hydatid cyst. This is due to the incorporation of biliary radicles into the pericyst. Itmay occur in three routes; namely, contained,communicating and direct. When the cyst contents escape via biliary or bronchial radicles, the rupture is communicating. Cysto-biliary communications can either be occult or frank and the frank CBC accounts for only 5%-15% of the cases. It occurs in the right duct in 55-60% of cases, in the left duct in 25- 30%, and rarely in the confluence or gallbladder. Although communication with the intrahepatic bile ducts is common, its occurrence between a hepatic hydatid cyst and the common bile duct is rare. We present an unusual case of a fistulous communication between a hepatic hydatid cyst and CBD and frank cyst evacuation in a 42-year-old man. The sonographic, abdominal CT scan and MR cholangiopancreatography (MRCP features have been discussed. The purpose of this report is to draw attention to this rare occurrence and to highlight the presentation and the imaging features of it.

  19. Justicia e igualdad en los sistemas especiales de admisión a las universidades: una reflexión a partir de Ronald Dworkin

    Directory of Open Access Journals (Sweden)

    Javier Orlando Aguirre-Román

    2010-03-01

    Full Text Available En Colombia, algunas universidades han adoptado sistemas especiales de admisión a favor de grupos sociales determinados; sistemas que han sido criticados e incluso desmontados supuestamente por violar el principio de igualdad y el mérito académico como criterio determinante del ingreso a una universidad. El artículo analiza los casos que han llegado a las altas cortes de justicia de los Estados Unidos y de Colombia con el fin de señalar las diferencias que tienen respecto de la igualdad y justificar, desde la filosofía del derecho de Ronald Dworkin, la legitimidad de algunos de esos sistemas.

  20. O Direito como Integridade na Jurisdição Constitucional: análise sobre o aborto segundo a proposta de Ronald Dworkin

    OpenAIRE

    Adriana de Campos; Daniel Piovanelli Ardisson

    2013-01-01

    http://dx.doi.org/10.5007/2177-7055.2013v34n67p251O presente artigo tem por objetivo analisar a proposta de Ronald Dworkin sobre o direito como integridade na jurisdição constitucional. Para tanto, ela será utilizada na análise da constitucionalidade ou não de crimes que tipificam o aborto no ordenamento jurídico brasileiro, levando em consideração as possíveis alternativas jurídico-doutrinárias para a decisão do caso. Busca-se discutir, com isso, se haveria um limite à aplicação da proposta ...

  1. La imaginación política. La influencia de Carroll Quigley y de Ronald Reagan en el discurso presidencial de Bill Clinton

    OpenAIRE

    2015-01-01

    En este artículo, se analizan las causas que impulsaron el cambio estratégico en la retórica institucional del presidente Clinton, enfatizando la imaginación política como factor decisivo. Durante la primera etapa (1993-1994) de su mandato, el presidente Clinton cometió errores manifiestos en una interlocución política que fluctuaba de manera irregular. Tras el fracaso de las elecciones de otoño de 1994, Clinton desarrolló todavía más la adaptación de técnicas que Ronald Reagan había expandid...

  2. TRATAMIENTO DOCTRINAL DE LA OBJECIÓN DE CONCIENCIA Y LA DESOBEDIENCIA CIVIL EN RONALD DWORKIN Y JÜRGEN HABERMAS.

    Directory of Open Access Journals (Sweden)

    Martha Elena Soto Obregón

    2013-05-01

    Full Text Available Las figuras de objeción de conciencia (OC y desobediencia civil (DC han sido estudiadas por diversos autores, pero muchos de ellos siempre acuden a los mismos referentes teóricos: “autores frontera” que estudian dichas figuras tangencialmente al cobijo de sus tesis fundamentales y que se convierten en referencia obligada -clásicos- para posteriores investigaciones. Esta situación es propia de la aplicación del principio de saturación. El objetivo de este ensayo es tomar a uno de esos autores frontera (Ronald Dworkin y Jürgen Habermas, y analizar a profundidad el ADN de la OC y de la DC y al mismo tiempo discutir con el autor respecto de la aplicación de sus premisas.

  3. When Deriving the Spatial QRS-T Angle from the 12-lead ECG, which Transform is More Frank: Regression or Inverse Dower?

    Science.gov (United States)

    Schlegel, Todd T.; Cortez, Daniel

    2010-01-01

    Our primary objective was to ascertain which commonly used 12-to-Frank-lead transformation yields spatial QRS-T angle values closest to those obtained from simultaneously collected true Frank-lead recordings. Simultaneous 12-lead and Frank XYZ-lead recordings were analyzed for 100 post-myocardial infarction patients and 50 controls. Relative agreement, with true Frank-lead results, of 12-to-Frank-lead transformed results for the spatial QRS-T angle using Kors regression versus inverse Dower was assessed via ANOVA, Lin s concordance and Bland-Altman plots. Spatial QRS-T angles from the true Frank leads were not significantly different than those derived from the Kors regression-related transformation but were significantly smaller than those derived from the inverse Dower-related transformation (P less than 0.001). Independent of method, spatial mean QRS-T angles were also always significantly larger than spatial maximum (peaks) QRS-T angles. Spatial QRS-T angles are best approximated by regression-related transforms. Spatial mean and spatial peaks QRS-T angles should also not be used interchangeably.

  4. Frank Isakson Prize for Optical Effects in Solids: Optical spectroscopy and mechanisms of superconductivity

    Science.gov (United States)

    van der Marel, Dirk

    vibrations of the lattice, and where the electron-electron interaction is purely repulsive. Invited talk because of the Frank Isakson Prize 2016.

  5. Frank Ross's Early Direct Photographs of Venus and His Interpretation of Them

    Science.gov (United States)

    Osterbrock, Donald E.

    2006-09-01

    Frank Ross was an outstandingly creative astronomical "jack of many trades" (Monet) or "cat with nine astronomical lives". After joining the Yerkes Observatory faculty in 1924, at age 50, he took a long series of almost nightly direct photographs of Venus in 1927 with the Mount Wilson 60-inch and 100-inch reflectors as a guest observer. He published many of these images in the ApJ in 1928, with his conclusions on the nature of Venus. Ross discovered markings, seen only in the ultraviolet images, parallel "belts" indicating rotation. They changed rapidly. From these photographs he developed a tentative picture of a deep opaque atmosphere, with high pressure at the surface of the planet. The changes were due to "violent events" (winds or storms) in its atmosphere. From spectroscopic results of Slipher, Adams, StJohn, and Nicholson he took the rotation period to be long. But bolometric observations of Pettit, Nicholson, Coblentz, and Lampland, indicated little temperature change between the illuminated and dark parts of the disk, so it could not be too slow. Ross settled on a "compromise" rotation period of about 30 days based on the data he had. The spectroscopic measurements showed there was very little, if any, H2O or O2 in the atmosphere. Ross is best known today for his Ross wide-angle camera design, his Ross high-proper-motion stars, his Ross photometer, and his Ross correctors for large reflecting telescopes, but his foray into planetary astronomy, long before the era of radar or close-up imaging and spectroscopy from space vehicles, was an important first step toward understanding Venus. His years of experience in laboratory studies of the properties of photographic plates, developers, and mensuration were highly important for this work. Equally so were his cheerful, peppery personality and his close relations with many Mount Wilson and Lowell Observatory staff members.

  6. Popular Science and Apocalyptic Narrative in Frank Schätzing’s The Swarm

    Directory of Open Access Journals (Sweden)

    Gabriele Dürbeck

    2012-01-01

    Full Text Available This paper analyses the use of the rhetoric of the Apocalypse and the concept of nature's revenge in Frank Schätzing's eco-thriller The Swarm. Ecocritical research has identified these narrative patterns as characteristic of contemporary environmental literature. In The Swarm, the apocalyptical rhetoric fulfils the double function of providing thrill and pleasure to the readers and warning them about imminent environmental peril, thereby combining conventions from the two genres of eco-thriller and science fiction. Contrasting reviews have described the novel as either enlightening or pseudo-religious. This ambivalence is the effect of various strategies employed to popularise scientific knowledge in the novel. The narrative embraces various scientific fields, for example the depiction of a network in contrast to swarm theory. The key conflict in the story embodies conflicting concepts of nature - anthropocentric vs. eco-systemic - which are represented by two contrasting groups of characters: one aiming to extinguish the alien superorganism that attacks the human race, the other aspiring to integrate the alien organism into the human world and propagating a holistic view of the Earth. The concepts of a 'tragic' and a 'comical apocalypse' correspond to the double closure which first features a show-down, the annihilation of the 'bad' characters, and then, in the epilogue, a warning message delivered by a 'good' character which confirms - in contrast to, for example, Michael Crichton's State of Fear - the ongoing environmental crisis. Although the epilogue extensively appeals to the human ability to rethink attitudes towards nature, the novel's support for environmental concerns is limited, not only because this message remains rather abstract but also because the vision of a reconciled, pseudo-religious ecosystem as a holistic superorganism has a highly ambivalent meaning for humanity.

  7. FRANK A. VANDERLIP AND THE NATIONAL CITY BANK DURING THE FIRST WORLD WAR

    Directory of Open Access Journals (Sweden)

    Priscilla Roberts

    2002-01-01

    Full Text Available This essay focuses on the First World War policies of the National City Bankof New York, drawing attention to the internal disputes within the bank over war financing. Some historians have suggested that during the First World War New York banks associated with the National City Bank favored fierce competition with the Allied powers for markets and overseas investment opportunities, whereas those linked to J. P Morgan and Company preferred cooperation with the Allied powers, concentrating upon handling the massive war financing the Allied war effort required. In reality the picture was more complex. The National City Bank participated substantially in Allied war loans and, with the First National Bank and Morgan’s, was one of the “Trio” of leading New York banks that handled such financing. Simultaneously, Frank A. Vanderlip, the National City president and a long-time advocate of the expansion of American foreign trade and investment, launched a major initiative to expand the National City’s overseas activities, through the establishment of foreign branches around the world and the creation of the American International Corporation, a foreign investment trust. Although Vanderlip suggested that he wished to cooperate with British financial interests in these activities, they generated conflict between the National City and the fiercely pro-Allied Morgan firm. Within the bank, they also created substantial tension between the broadly neutral Vanderlip and his staunchly pro-Allied patron, the bank’s chairman, James Stillman, who diedin 1918, and other strongly pro-Allied National City officers. Shortly afterthe war, Vanderlip proposed a massive and visionary scheme to provide American financing for European economic regeneration, causing the National City’s directors, who considered it impractical and outside their bank’s remit of maximizing profits, to dismiss him.

  8. The inaugural Frank Ellis Lecture--latrogenic cancer: the impact of intensity-modulated radiotherapy.

    Science.gov (United States)

    Hall, E J

    2006-05-01

    It is an honour and personal pleasure to give the inaugural Frank Ellis Lecture to celebrate his 100th birthday, and to acknowledge his enormous contributions to radiation oncology. Intensity-modulated radiotherapy (IMRT) allows dose to be concentrated in the tumour volume while sparing normal tissues. However, the downside to IMRT is the potential to increase the number of radiation-induced second cancers because more fields are used which involves a bigger volume of normal tissue exposed to lower doses. It has been estimated that IMRT may double the incidence of solid cancers in long-term survivors. This may be acceptable in older patients if balanced by an improvement in local tumour control and reduced toxicity. On the other hand, the incidence of second cancers is higher in children, so that doubling it may not be acceptable. IMRT represents a special case for children. First, they are more sensitive to radiation-induced cancer than adults. Second, radiation scattered from the treatment volume is more important in the small body of the child. Third, there is the question of genetic susceptibility, as many childhood cancers involve a germline mutation. The levels of leakage radiation in current Linacs can be reduced, but the cost would be substantial. An alternative strategy is to replace X-rays with protons. This is an advantage only if the proton machine uses a pencil scanning beam, as passive modulation of a scattering foil produces neutrons, which results in an effective dose to the patient higher than that characteristic of IMRT.

  9. The failing human heart is unable to use the Frank-Starling mechanism.

    Science.gov (United States)

    Schwinger, R H; Böhm, M; Koch, A; Schmidt, U; Morano, I; Eissner, H J; Uberfuhr, P; Reichart, B; Erdmann, E

    1994-05-01

    There is evidence that the failing human left ventricle in vivo subjected to additional preload is unable to use the Frank-Starling mechanism. The present study compared the force-tension relation in human nonfailing and terminally failing (heart transplants required because of dilated cardiomyopathy) myocardium. Isometric force of contraction of electrically driven left ventricular papillary muscle strips was studied under various preload conditions (2 to 20 mN). To investigate the influence of inotropic stimulation, the force-tension relation was studied in the presence of the cardiac glycoside ouabain. In skinned-fiber preparations of the left ventricle, developed tension was measured after stretching the preparations to 150% of the resting length. To evaluate the length-dependent activation of cardiac myofibrils by Ca2+ in failing and nonfailing myocardium, the tension-Ca2+ relations were also measured. After an increase of preload, the force of contraction gradually increased in nonfailing myocardium but was unchanged in failing myocardium. There were no differences in resting tension, muscle length, or cross-sectional area of the muscles between both groups. Pretreatment with ouabain (0.02 mumol/L) restored the force-tension relation in failing myocardium and preserved the force-tension relation in nonfailing tissue. In skinned-fiber preparations of the same hearts, developed tension increased significantly after stretching only in preparations from nonfailing but not from failing myocardium. The Ca2+ sensitivity of skinned fibers was significantly higher in failing myocardium (EC50, 1.0; 95% confidence limit, 0.88 to 1.21 mumol/L) compared with nonfailing myocardium (EC50, 1.7; 95% confidence limit, 1.55 to 1.86 mumol/L). After increasing the fiber length by stretching, a significant increase in the sensitivity of the myofibrils to Ca2+ was observed in nonfailing but not in failing myocardium. These experiments provide evidence for an impaired force

  10. Depth distribution of Frank loop defects formed in ion-irradiated stainless steel and its dependence on Si addition

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Dongyue, E-mail: dychen@safety.n.t.u-tokyo.ac.jp [The University of Tokyo, Department of Nuclear Engineering and Management, School of Engineering, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656 (Japan); Murakami, Kenta [The University of Tokyo, Nuclear Professional School, School of Engineering, 2-22 Shirakata-Shirane, Tokai-mura, Ibaraki 319-1188 (Japan); Dohi, Kenji; Nishida, Kenji; Soneda, Naoki [Central Research Institute of Electric Power Industry, 2-11-1 Iwado-kita, Komae, Tokyo 201-8511 (Japan); Li, Zhengcao, E-mail: zcli@tsinghua.edu.cn [Tsinghua University, School of Materials Science and Engineering, Beijing 100084 (China); Liu, Li; Sekimura, Naoto [The University of Tokyo, Department of Nuclear Engineering and Management, School of Engineering, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656 (Japan)

    2015-12-15

    Although heavy ion irradiation is a good tool to simulate neutron irradiation-induced damages in light water reactor, it produces inhomogeneous defect distribution. Such difference in defect distribution brings difficulty in comparing the microstructure evolution and mechanical degradation between neutron and heavy ion irradiation, and thus needs to be understood. Stainless steel is the typical structural material used in reactor core, and could be taken as an example to study the inhomogeneous defect depth distribution in heavy ion irradiation and its influence on the tested irradiation hardening by nano-indentation. In this work, solution annealed stainless steel model alloys are irradiated by 3 MeV Fe{sup 2+} ions at 400 °C to 3 dpa to produce Frank loops that are mainly interstitial in nature. The silicon content of the model alloys is also tuned to change point defect diffusion, so that the loop depth distribution influenced by diffusion along the irradiation beam direction could be discussed. Results show that in low Si (0% Si) and base Si (0.42% Si) samples the depth distribution of Frank loop density quite well matches the dpa profile calculated by the SRIM code, but in high Si sample (0.95% Si), the loop number density in the near-surface region is very low. One possible explanation could be Si’s role in enhancing the effective vacancy diffusivity, promoting recombination and thus suppressing interstitial Frank loops, especially in the near-surface region, where vacancies concentrate. By considering the loop depth distribution, the tested irradiation hardening is successfully explained by the Orowan model. A hardening coefficient of around 0.30 is obtained for all the three samples. This attempt in interpreting hardening results may make it easier to compare the mechanical degradation between different irradiation experiments.

  11. The external work-pressure time integral relationships and the afterload dependence of Frank-Starling mechanism.

    Science.gov (United States)

    Sela, Gali; Landesberg, Amir

    2009-10-01

    The mechanisms underlying the Frank-Starling Law of the heart are elusive and the prevalent notion suggests that it is afterload independent. However, isolated fiber studies reveal that the afterload determines cardiac function through cross-bridge dependent mechanisms. The study explores the roles of the afterload, in situ. The LV was exposed by left-thoracotomy in adult sheep (72.6+/-8.2 kg, n=8). Pressure transducers were inserted into the LV and aorta, a flowmeter was placed around the aortic root, and the LV volume was assessed by sonocrystals. Occluders around the aorta and the inferior vena cava enabled control of the afterload and preload. Different afterloads were imposed by partial aortic occlusions. Transient inferior vena cava occlusions (IVCOs) were preformed whenever the afterload was steady. A highly linear relationship was found between the external work (EW) and pressure time integral (PTI) (R(2)=0.98+/-0.01) during each transient IVCO (n=48). The slope of the EW-PTI relationship (WPTiR) was preload independent since, for any given afterload, the EW and PTI lay on a straight line. Interestingly, the slope of the WPTiR was afterload dependant: The slope was 33.3+/-4.1 mJ/mmHg.s at baselines and decreased by 1.0+/-0.50 mJ/mmHg.s with every 1 mmHg.min/L increase in the peripheral resistance. A unique WPTiR was obtained during both the occlusion and release phases of each IVCO, while two distinct EW-preload or PTI-preload relationships were observed. The novel WPTiR ties the Frank (pressure development) and Starling (EW production) phenomena together. The dependence of the WPTiR on the afterload highlights the adaptive control of the Frank-Starling mechanisms to changes in the afterload.

  12. Photography in the boundaries of the visible. From Santiago Ramón y Cajal to Cecil Frank Powell

    Directory of Open Access Journals (Sweden)

    Francisco López-Cantos

    2016-12-01

    Full Text Available In this article, we analyze the use of photographic technologies of two renowned researchers whose investigation results would have been impossible to carry out, as occurs in Galileo a few centuries before with the use of imaging techniques, without the use of photography: Santiago Ramón y Cajal and Cecil Frank Powell, Nobel Prize winners in medicine in 1906 and in physics in 1950, respectively. These researchers were selected, first, because of their close relation with photography and, second, to clearly illustrate the gradual transgression of scientific photographic representation starting in the late nineteenth century from the visible to the invisible.

  13. Editorial Special issue on control theory and applications in honor of the 60th birthday of Professor Frank L. Lewis

    Institute of Scientific and Technical Information of China (English)

    Ben M.CHEN; Gang FENG

    2010-01-01

    @@ It is our great pleasure to put up this special issue in Journal of Control Theory and Applications in honor of the 60th birthday of Professor Frank Lewis, who has made many significant contributions to the field of control engineering through the years, and who is regarded as a pioneer in many areas in control and automation, which includes applied optimal control and geometric systems theory in his earlier research period, and his recent focus on intelligent nonlinear control, neural network feedback control, optimal control for nonlinear systems, H-infinity (game theory) control, approximate dynamic programming, discrete event supervisory control, intelligent diagnostics and prognostics, to name a few.

  14. ´Imperio estético: griegos frente a persas según 300 de Frank Miller

    OpenAIRE

    Díez Platas, Fátima

    2011-01-01

    Este trabajo pretende realizar un análisis iconográfico y estético de la peculiar imagen que ofrece del imperio persa la adaptación cinematográfica de la novela gráfica de Frank Miller 300 (Z. Snyder, 2007). Partiendo de la idea de que la evidente deformación de la representación obedece al giro poético que supone presentar la realidad desde el punto de vista de los espartanos, se examinan las imágenes como el producto de una versión personal, y se exploran las razones a las que ...

  15. Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law

    Directory of Open Access Journals (Sweden)

    Lorenzo Fassina

    2015-01-01

    Full Text Available We have studied beating mouse cardiac syncytia in vitro in order to assess the inotropic, ergotropic, and chronotropic effects of both increasing and decreasing hydrostatic pressures. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of those pressure-loaded beating syncytia starting from the video registration of their contraction movement. By this analysis, we have verified the Frank-Starling law of the heart in in vitro beating cardiac syncytia and we have obtained their geometrical-functional classification.

  16. Modulation of the cardiomyocyte contraction inside a hydrostatic pressure bioreactor: in vitro verification of the Frank-Starling law.

    Science.gov (United States)

    Fassina, Lorenzo; Magenes, Giovanni; Gimmelli, Roberto; Naro, Fabio

    2015-01-01

    We have studied beating mouse cardiac syncytia in vitro in order to assess the inotropic, ergotropic, and chronotropic effects of both increasing and decreasing hydrostatic pressures. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of those pressure-loaded beating syncytia starting from the video registration of their contraction movement. By this analysis, we have verified the Frank-Starling law of the heart in in vitro beating cardiac syncytia and we have obtained their geometrical-functional classification.

  17. Un altro tipo di ordine. Frank O. Gehry e il progetto di un grande edificio urbano a Berlino / Another Type of Order. Frank O. Gehry and the project of a large urban building in Berlin

    Directory of Open Access Journals (Sweden)

    Lorenzo Margiotta

    2016-04-01

    Full Text Available L’opera di Frank O. Gehry dà la possibilità di incontrare un ricco universo di tecniche compositive alternative rispetto a quelle di cui si avvalgono la maggior parte degli architetti del ‘900. L’architetto californiano, con la sua dimensione ironica, caricaturale, anti-classica, racconta di un modo alternativo di presentare nella città l’oggetto architettonico e di intendere “l’appropriata collocazione delle cose” e la “scelta dell’effetto dell’opera”, come testimonia il grande edificio urbano costruito a Berlino, in uno dei luoghi più importanti della storia europea. / The work of Frank O. Gehry gives the chance to meet a rich universe of alternative compositional techniques than those of the architects of the ‘900. The Californian architect, with his ironic dimension, caricature, anti-classical, talks about an alternative way of presenting the architectural object in the city and about an alternative way of understanding “the proper placement of things” and the “choice of the effect of the works”, as evidenced by the large urban building built in Berlin, in one of the most important places of European history.

  18. Effects of temperature on the nitric oxide-dependent modulation of the Frank-Starling mechanism: the fish heart as a case study.

    Science.gov (United States)

    Amelio, D; Garofalo, F; Capria, C; Tota, B; Imbrogno, S

    2013-02-01

    The Frank-Starling law is a fundamental property of the vertebrate myocardium which allows, when the end-diastolic volume increases, that the consequent stretch of the myocardial fibers generates a more forceful contraction. It has been shown that in the eel (Anguilla anguilla) heart, nitric oxide (NO) exerts a direct myocardial relaxant effect, increasing the sensitivity of the Frank-Starling response (Garofalo et al., 2009). With the use of isolated working heart preparations, this study investigated the relationship between NO modulation of Frank-Starling response and temperature challenges in the eel. The results showed that while, in long-term acclimated fish (spring animals perfused at 20 °C and winter animals perfused at 10 °C) the inhibition of NO production by L-N5 (1-iminoethyl)ornithine (L-NIO) significantly reduced the Frank-Starling response, under thermal shock conditions (spring animals perfused at 10 or 15 °C and winter animals perfused at 15 or 20 °C) L-NIO treatment resulted without effect. Western blotting analysis revealed a decrease of peNOS and pAkt expressions in samples subjected to thermal shock. Moreover, an increase in Hsp90 protein levels was observed under heat thermal stress. Together, these data suggest that the NO synthase/NO-dependent modulation of the Frank-Starling mechanism in fish is sensitive to thermal stress.

  19. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from underway - surface observations using Barometric pressure sensor, Carbon dioxide (CO2) gas analyzer and other instruments from NOAA Ship RONALD H. BROWN in the North Atlantic Ocean, North Pacific Ocean and others from 2008-01-22 to 2009-01-11 (NODC Accession 0109930)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0109930 includes biological, chemical, meteorological, physical and underway - surface data collected from NOAA Ship RONALD H. BROWN in the North...

  20. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Barometric pressure sensor, Carbon dioxide (CO2) gas analyzer and other instruments from NOAA Ship RONALD H. BROWN in the Caribbean Sea, North Atlantic Ocean and South Atlantic Ocean from 2013-07-18 to 2013-10-31 (NODC Accession 0117689)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0117689 includes Surface underway, chemical, meteorological and physical data collected from NOAA Ship RONALD H. BROWN in the Caribbean Sea, North...

  1. Partial pressure (or fugacity) of carbon dioxide, dissolved inorganic carbon, pH, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using Alkalinity titrator, CTD and other instruments from NOAA Ship RONALD H. BROWN in the North Pacific Ocean, South Pacific Ocean and Southern Oceans from 2007-12-15 to 2008-02-23 (NODC Accession 0109903)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0109903 includes discrete sample and profile data collected from NOAA Ship RONALD H. BROWN in the North Pacific Ocean, South Pacific Ocean and...

  2. Partial pressure (or fugacity) of carbon dioxide, dissolved inorganic carbon, pH, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using Alkalinity titrator, CTD and other instruments from NOAA Ship RONALD H. BROWN in the South Atlantic Ocean from 2011-09-26 to 2011-10-31 (NODC Accession 0109914)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0109914 includes discrete sample and profile data collected from NOAA Ship RONALD H. BROWN in the South Atlantic Ocean from 2011-09-26 to 2011-10-31....

  3. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Barometric pressure sensor, Carbon dioxide (CO2) gas analyzer and other instruments from NOAA Ship RONALD H. BROWN in the North Atlantic Ocean and South Atlantic Ocean from 2013-07-18 to 2013-10-02 (NODC Accession 0117699)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0117699 includes Surface underway, chemical, meteorological and physical data collected from NOAA Ship RONALD H. BROWN in the North Atlantic Ocean and...

  4. Partial pressure (or fugacity) of carbon dioxide, dissolved inorganic carbon, pH, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments from NOAA Ship RONALD H. BROWN in the North Atlantic Ocean from 1998-01-24 to 1998-02-23 (NODC Accession 0113920)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0113920 includes chemical, discrete sample, physical and profile data collected from NOAA Ship RONALD H. BROWN in the North Atlantic Ocean from...

  5. Partial pressure (or fugacity) of carbon dioxide, dissolved inorganic carbon, pH, alkalinity, temperature, salinity and other variables collected from discrete sample, profile and underway - surface observations using Alkalinity titrator, CTD and other instruments from NOAA Ship RONALD H. BROWN in the North Atlantic Ocean and South Atlantic Ocean from 2010-03-08 to 2010-04-17 (NODC Accession 0108156)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0108156 includes chemical, discrete sample, meteorological, physical, profile and underway - surface data collected from NOAA Ship RONALD H. BROWN in...

  6. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from Surface underway observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from NOAA Ship RONALD H. BROWN in the South Atlantic Ocean from 2013-12-23 to 2014-02-04 (NODC Accession 0116979)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0116979 includes Surface underway, chemical, meteorological and physical data collected from NOAA Ship RONALD H. BROWN in the South Atlantic Ocean...

  7. Partial pressure (or fugacity) of carbon dioxide, dissolved inorganic carbon, pH, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using Alkalinity titrator, CTD and other instruments from NOAA Ship RONALD H. BROWN in the North Atlantic Ocean and South Atlantic Ocean from 2003-06-04 to 2003-08-11 (NODC Accession 0108061)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0108061 includes discrete sample and profile data collected from NOAA Ship RONALD H. BROWN in the North Atlantic Ocean and South Atlantic Ocean from...

  8. Mechanoelectric feedback does not contribute to the Frank-Starling relation in the rat and guinea pig heart

    Directory of Open Access Journals (Sweden)

    D Kelly

    2014-12-01

    Full Text Available Mechanoelectric feedback (MEF is the process by which mechanical forces on the myocardium can alter its electrical properties. The effect can be large enough to induce ectopic beats or fibrillation. However, the role of MEF at physiological levels of mechanical stress is not clear. We have investigated alteration in action potential morphology in rat and guinea pig ventricle and in rat atrial tissue at levels of stretch near the plateau of the Frank-Starling curve. Stretch of >100 mm.Hg End Diastolic Left Ventricular Pressure (EDLVP or rapidly applied stretch (EDLVP increased by 25 mm.Hg within 100 ms often triggered ectopic beats in isolated rat and guinea-pig hearts. However, ventricular epicardial monophasic action potentials (MAPs recorded during stretch to EDLVP up to 30 mm. Hg showed no consistent changes in action potential duration (at APD20, APD50 or APD80 in either species. MAP recording detected APD prolongation with very small concentrations of 4-AP (10 μM, confirming the discrimination of the recording technique. In isolated rat atrial strips, no changes in intracellular action potential morphology or membrane potential were seen when stretched to levels producing an optimum increase in contractility. We conclude that alteration in action potential morphology with stretch does not contribute to the Frank-Starling relation in ventricle of rat or guinea-pig isolated heart, or in rat atrial tissue.

  9. Examining the response pressure along a fluid-filled elastic tube to comprehend Frank's arterial resonance model.

    Science.gov (United States)

    Lin Wang, Yuh-Ying; Sze, Wah-Keung; Lin, Chin-Chih; Chen, Jiang-Ming; Houng, Chin-Chi; Chang, Chi-Wei; Wang, Wei-Kung

    2015-04-13

    Frank first proposed the arterial resonance in 1899. Arteries are blood-filled elastic vessels, but resonance phenomena for a fluid-filled elastic tube has not drawn much attention yet. In this study, we measured the pressure along long elastic tubes in response to either a single impulsive water ejection or a periodic water input. The experimental results showed the low damped pressure oscillation initiated by a single impulsive water input; and the natural frequencies of the tube, identified by the peaks of the response in the frequency domain, were inversely proportional to the length of the tube. We found that the response to the periodic input reached a steady distributed oscillation with the same period of the input after a short transient time; and the optimal pressure response, or resonance, occurred when the pumping frequency was near the fundamental natural frequency of the system. We pointed out that the distributed forced oscillation could also be a suitable approach to analyze the arterial pressure wave. Unlike Frank's resonance model in which the whole arterial system was lumped together to a simple 0-D oscillator and got only one natural frequency, a tube has more than one natural frequency because the pressure P(z,t) is a 1-D oscillatory function of the axial position z and the time t. The benefit of having more than one natural frequency was then discussed.

  10. The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment.

    Science.gov (United States)

    Wannenburg, T; Janssen, P M; Fan, D; de Tombe, P P

    1997-11-01

    We tested the hypothesis that the Frank-Starling relationship is mediated by changes in the rate of cross-bridge detachment in cardiac muscle. We simultaneously measured isometric force development and the rate of ATP consumption at various levels of Ca2+ activation in skinned rat cardiac trabecular muscles at three sarcomere lengths (2.0, 2.1, and 2.2 microns). The maximum rate of ATP consumption was 1.5 nmol.s-1.microliter fiber vol-1, which represents an estimated adenosinetriphosphatase (ATPase) rate of approximately 10 s-1 per myosin head at 24 degrees C. The rate of ATP consumption was tightly and linearly coupled to the level of isometric force development, and changes in sarcomere length had no effect on the slope of the force-ATPase relationships. The average slope of the force-ATPase relationships was 15.5 pmol.mN-1.mm-1. These results suggest that the mechanisms that underlie the Frank-Starling relationship in cardiac muscle do not involve changes in the kinetics of the apparent detachment step in the cross-bridge cycle.

  11. Exhaustion of the Frank-Starling mechanism in conscious dogs with heart failure induced by chronic coronary microembolization.

    Science.gov (United States)

    Gill, Robert M; Jones, Bonita D; Corbly, Angela K; Ohad, Dan G; Smith, Gerald D; Sandusky, George E; Christe, Michael E; Wang, Jie; Shen, Weiqun

    2006-07-04

    The role of the Frank-Starling mechanism in the regulation of cardiac systolic function in the ischemic failing heart was examined in conscious dogs. Left ventricular (LV) dimension, pressure and systolic function were assessed using surgically implanted instrumentations and non-invasive echocardiogram. Heart failure was induced by daily intra-coronary injections of microspheres for 3-4 weeks via implanted coronary catheters. Chronic coronary embolization resulted in a progressive dilation of the left ventricle (12+/-3%), increase in LV end-diastolic pressure (118+/-19%), depression of LV dP/dt(max) (-19+/-4%), fractional shortening (-36+/-7%), and cardiac work (-60+/-9%), and development of heart failure, while the LV contractile response to dobutamine was depressed. A brief inferior vena caval occlusion in dogs with heart failure decreased LV preload to match the levels attained in their control state and caused a further reduction of LV dP/dt(max), fractional shortening, stroke work and cardiac work. Moreover, in response to acute volume loading, the change in the LV end-diastolic dimension-pressure (DeltaLVEDD-DeltaLVEDP) curve in the failing heart became steeper and shifted significantly to the left, while the increases in LV stroke work and cardiac work were blunted. Thus, our results suggest that the Frank-Starling mechanism is exhausted in heart failure and unable to further respond to increasing volume while it plays an important compensatory role in adaptation to LV dysfunction in heart failure.

  12. Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.

    Science.gov (United States)

    Scotcher, Jenna; Prysyazhna, Oleksandra; Boguslavskyi, Andrii; Kistamas, Kornel; Hadgraft, Natasha; Martin, Eva D; Worthington, Jenny; Rudyk, Olena; Rodriguez Cutillas, Pedro; Cuello, Friederike; Shattock, Michael J; Marber, Michael S; Conte, Maria R; Greenstein, Adam; Greensmith, David J; Venetucci, Luigi; Timms, John F; Eaton, Philip

    2016-10-26

    The Frank-Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and oxidants are produced. Here we show that protein kinase G Iα (PKGIα) is oxidant-activated during stretch and this form of the kinase selectively phosphorylates cardiac phospholamban Ser16-a site important for diastolic relaxation. We find that hearts of Cys42Ser PKGIα knock-in (KI) mice, which are resistant to PKGIα oxidation, have diastolic dysfunction and a diminished ability to couple ventricular filling with cardiac output on a beat-to-beat basis. Intracellular calcium dynamics of ventricular myocytes isolated from KI hearts are altered in a manner consistent with impaired relaxation and contractile function. We conclude that oxidation of PKGIα during myocardial stretch is crucial for diastolic relaxation and fine-tunes the Frank-Starling response.

  13. Carbon Dioxide, Hydrographic, and Chemical Data Obtained During the R/V Ronald H. Brown Repeat Hydrography Cruise in the Atlantic Ocean: CLIVAR CO2 Section A16S_2005 (11 January - 24 February, 2005)

    Energy Technology Data Exchange (ETDEWEB)

    Kozyr, Alex [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Carbon Dioxide Information Analysis Center

    2006-08-30

    This report presents methods, and analytical and quality control procedures for salinity, oxygen, nutrient, inorganic carbon, organic carbon, chlorofluorocarbon (CFC), and bomb 14C system parameters performed during the A16S_2005 cruise, which took place from January 11 to February 24, 2005, aboard research vessel (R/V) Ronald H. Brown under the auspices of the National Oceanic and Atmospheric Administration (NOAA). The R/V Ronald H. Brown departed Punta Arenas, Chile, on January 11, 2005, and ended its cruise in Fortaleza, Brazil, on February 24, 2005. The research conducted was one of a series of repeat hydrography sections jointly funded by NOAA and the National Science Foundation as part of the CLIVAR/CO2/repeat hydrography/tracer program. Samples were taken from 36 depths at 121 stations. The data presented in this report include the analyses of water samples for total inorganic carbon (TCO2), fugacity of CO2 (fCO2), total alkalinity (TALK), pH, dissolved organic carbon (DOC), CFC, 14C, hydrographic, and other chemical measurements. The R/V Ronald H. Brown A16S_2005 data set is available free of charge as a numeric data package (NDP) from the Carbon Dioxide Information Analysis Center (CDIAC). The NDP consists of the oceanographic data files and this printed documentation, which describes the procedures and methods used to obtain the data.

  14. Taking salience seriously: the viability of Ronald Dworkin’s theory of salience in the context of extra-territorial corporate accountability

    Directory of Open Access Journals (Sweden)

    David Brian Dennison

    2015-11-01

    Full Text Available In his posthumously published article “A New Philosophy for International Law”, Ronald Dworkin advocates for the use of “salience” as means for generating international law. Dworkin argues that the consent-based mechanisms for establishing international law are often incapable of addressing collective challenges such as change. Dworkin’s salience in alternative means for creating international law whereby the law can emerge from widely held principles and practices without the necessity of global sovereign consent. Unfortunately and somewhat ironically, Dworkin’s essay on salience does not include non-consent based mechanisms for salience to obtain international recognition as a legitimate engine for creating international law. This essay offers international corporate accountability is a fertile area for the emergence of salience as a source of international law. Dworkin’s description of salience and its law-forming capacity speaks to what can take place and what is taking place in the development of this area of law. Salience presents a theoretical construct that can nurture the development of coherent and extra-referential standards for judicial engagement with extra-territorial corporate wrongs. Thus the use of salience in the context of international corporate accountability is well-suited for the specific task at hand and can offer a stage whereby salience can prove its worth and legitimacy as a source of international law.

  15. O Direito como Integridade na Jurisdição Constitucional: análise sobre o aborto segundo a proposta de Ronald Dworkin

    Directory of Open Access Journals (Sweden)

    Adriana Campos

    2013-12-01

    Full Text Available http://dx.doi.org/10.5007/2177-7055.2013v34n67p251O presente artigo tem por objetivo analisar a proposta de Ronald Dworkin sobre o direito como integridade na jurisdição constitucional. Para tanto, ela será utilizada na análise da constitucionalidade ou não de crimes que tipificam o aborto no ordenamento jurídico brasileiro, levando em consideração as possíveis alternativas jurídico-doutrinárias para a decisão do caso. Busca-se discutir, com isso, se haveria um limite à aplicação da proposta do filósofo do direito, e se, de fato, sempre haverá apenas uma resposta certa, ou se pode haver situações em que existirão várias respostas possíveis, mesmo com a utilização da teoria do direito como integridade

  16. Small marine craft emission factors observed from the NOAA R/V Ronald H. Brown during TexAQS/GoMACCS 2006

    Science.gov (United States)

    Lerner, B. M.; Lack, D.; Murphy, P. C.; Williams, E. J.

    2007-12-01

    During the TexAQS/GoMACCS 2006 field campaign, the NOAA R/V Ronald H. Brown often encountered small marine recreational craft and small fishing vessels while sailing close to the Texas coast, especially in Galveston Bay. Measurement of a suite of trace gases at high time resolution (1 Hz) allowed us to calculate emission factors (EFs), relative to carbon dioxide, for nitrogen oxides (NOx), sulfur dioxide (SO2) and carbon monoxide (CO) for distinct exhaust plumes from these sources. Photoacoustic aerosol absorption spectroscopy (PAS) measurements made concurrently allowed for the first quantification of mass EFs for light-absorbing particles from fishing craft. As previously observed along the New England coast, gasoline-powered recreational vessels showed significantly higher NOx/CO2 and lower CO/CO2 EFs than current emissions inventories predict, although in agreement with the most recent published literature of laboratory studies. These findings imply lower volatile organic compound emissions from these vessels, although this was not directly measured.

  17. Myocardial response to incremental exercise in endurance-trained athletes: influence of heart rate, contractility and the Frank-Starling effect.

    Science.gov (United States)

    Warburton, Darren E R; Haykowsky, Mark J; Quinney, H Arthur; Blackmore, Derrick; Teo, Koon K; Humen, Dennis P

    2002-09-01

    Recent evidence indicates that endurance-trained athletes are able to increase their stroke volume (SV) throughout incremental upright exercise, probably due to a progressively greater effect of the Frank-Starling mechanism. This is contrary to the widely held belief that SV reaches a plateau at a submaximal heart rate (irrespective of fitness level), owing to a limitation in the time for diastolic filling. The purpose of this investigation was to evaluate whether endurance-trained athletes rely on a progressively greater effect of the Frank-Starling mechanism throughout incremental exercise. A secondary purpose was to evaluate the effects of postural position on the cardiovascular responses to incremental exercise. Ten male cyclists participated in this investigation. Left ventricular function was assessed throughout incremental exercise in the supine and upright positions (counterbalanced) using radionuclide ventriculography. Stroke volume increased in a linear fashion during incremental exercise in both the upright and supine positions. The increases in cardiac output (Q) throughout incremental to maximal exercise (in both the supine and upright positions) were significantly related to changes in heart rate, myocardial contractility and the Frank-Starling mechanism. Percentage changes in end-diastolic volume and SV were significantly greater in the upright position versus the supine position, reflecting an increased reliance on the Frank-Starling effect to increase Q. We conclude from this investigation that highly trained endurance athletes are able to make progressively increasing usage of the Frank-Starling effect throughout incremental exercise. Postural position has a significant effect on the relative contribution of heart rate, myocardial contractility and the Frank-Starling mechanism to the increase in Q during exercise conditions.

  18. Study and application of the balloon frame system to the industrialization of housing: the case of the American System-Built Houses of Frank Lloyd Wright

    Directory of Open Access Journals (Sweden)

    B. Serra Soriano

    2017-06-01

    Full Text Available Within his large architectural production, Frank Lloyd Wright had the opportunity to experiment with the timber industrialization, linking a traditional material with the modern sense of architecture. Wood and Frank Lloyd Wright are inseparable from the balloon frame system, a system which he will use at his first housing and through which he will materialize the spatial decomposition concept. The research on the particular American System-Built Houses case will serve to show the earliest experiences of Wright with the industry, whose conclusions he would use for subsequent researches on prefabrication.

  19. Combustion testing and heat recovery study: Frank E. Van Lare Wastewater Treatment Plant, Monroe County. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-01-01

    The objectives of the study were to record and analyze sludge management operations data and sludge incinerator combustion data; ascertain instrumentation and control needs; calculate heat balances for the incineration system; and determine the feasibility of different waste-heat recovery technologies for the Frank E. Van Lare (FEV) Wastewater Treatment Plant. As an integral part of this study, current and pending federal and state regulations were evaluated to establish their impact on furnace operation and subsequent heat recovery. Of significance is the effect of the recently promulgated Federal 40 CFR Part 503 regulations on the FEV facility. Part 503 regulations were signed into law in November 1992, and, with some exceptions, affected facilities must be in compliance by February 19, 1994. Those facilities requiring modifications or upgrades to their incineration or air pollution control equipment to meet Part 503 regulations must be in compliance by February 19, 1995.

  20. Frank Robert Tangherlini — the Founder of an Alternative Relativistic Kinematics (On the Occasion of His 85th Birthday

    Directory of Open Access Journals (Sweden)

    Malykin G. B.

    2009-01-01

    Full Text Available Already fifty years ago, Frank Robert Tangherlini, an American theoretical physicist, suggested an original procedure which, targeting the synchronization of clocks located in two different inertial reference frames of the space, was di erent from that Einstein had introduced. As a result of these, Tangherlini had deduced the so-called the Tangher- lini transformations, which are a sort of the transformations of the spatial coordinates and time being moved from one inertial reference frame into another one. The Tangher- lini transformations differ from the Lorentz transformations (which can be meant clas- sic ones in the theory of relativity and, in particular, suggest the velocity of light to be anisotropic in a moving inertial reference frame. The Tangherlini transformations be- ing applied provide adequate explanations to all well-known interference experiments checking of the Special Theory of Relativity.

  1. "... because I'm Batman" : En undersökning av maskulinitet i Frank Millers Batman: The Dark Knight Returns

    OpenAIRE

    Nilsson, Kristina

    2015-01-01

    I detta arbete kommer jag att undersöka hur maskulinitet gestaltas i Frank Millers Batman: The Dark Knight Returns. Det jag vill fokusera på är de olika maskulina drag som går att urskilja i serien. Warner Bros. Animation gav 2012 ut den första delen av en animerad filmatisering av Millers Batman-serie, som senare följdes av den andra och avslutande delen 2013. I min undersökning kommer jag även att ta hjälp av de båda animeringarna för att se på vilka sätt maskuliniteten gestaltas hos de oli...

  2. Myths and verities in protein folding theories: From Frank and Evans iceberg-conjecture to explanation of the hydrophobic effect

    Science.gov (United States)

    Ben-Naim, Arieh

    2013-10-01

    Starting from the seminal article by Frank and Evans where the "iceberg formation" idea was first expressed, we follow the evolution of this idea to the explanation of the hydrophobic effect. We show that the idea of iceberg formation can provide an explanation to the entropy, and enthalpy of solvation of non-polar solutes in water, provided one first explains why a simple non-polar solute would form icebergs in the first place. Having done that, the questions regarding the outstanding large hydrophobic solvation Gibbs energy remains unexplained. This conclusion follows from the exact entropy-enthalpy-compensation pertaining to any structural changes induced in the solvent. We also comment on some misinterpretation of the partial molar heat capacity of non-polar solutes in water.

  3. Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism.

    Science.gov (United States)

    Montgomery, David E; Rundell, Veronica L M; Goldspink, Paul H; Urboniene, Dalia; Geenen, David L; de Tombe, Pieter P; Buttrick, Peter M

    2005-11-01

    Myofilament dysfunction is a common point of convergence for many forms of heart failure. Recently, we showed that cardiac overexpression of PKC epsilon initially depresses myofilament activity and then leads to a progression of changes characteristic of human heart failure. Here, we examined the effects of PKC epsilon on contractile reserve, Starling mechanism, and myofilament activation in this model of end-stage dilated cardiomyopathy. Pressure-volume loop analysis and echocardiography showed that the PKC epsilon mice have markedly compromised systolic function and increased end-diastolic volumes. Dobutamine challenge resulted in a small increase in contractility in PKC epsilon mice but failed to enhance cardiac output. The PKC epsilon mice showed a normal length-dependent tension development in skinned cardiac muscle preparations, although Frank-Starling mechanism appeared to be compromised in the intact animal. Simultaneous measurement of tension and ATPase demonstrated that the maximum tension and ATPase were markedly lower in the PKC epsilon mice at any length or Ca2+ concentration. However, the tension cost was also lower indicating less energy expenditure. We conclude 1) that prolonged overexpression of PKC epsilon ultimately leads to a dilated cardiomyopathy marked by exhausted contractile reserve, 2) that PKC epsilon does not compromise the Frank-Starling mechanism at the myofilament level, and 3) that the Starling curve excursion is limited by the inotropic state of the heart. These results reflect the significance of the primary myofilament contractilopathy induced by phosphorylation and imply a role for PKC epsilon-mediated phosphorylation in myofilament physiology and the pathophysiology of decompensated cardiac failure.

  4. Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial load.

    Science.gov (United States)

    Chantler, Paul D; Melenovsky, Vojtech; Schulman, Steven P; Gerstenblith, Gary; Becker, Lewis C; Ferrucci, Luigi; Fleg, Jerome L; Lakatta, Edward G; Najjar, Samer S

    2012-01-01

    Effective arterial elastance(E(A)) is a measure of the net arterial load imposed on the heart that integrates the effects of heart rate(HR), peripheral vascular resistance(PVR), and total arterial compliance(TAC) and is a modulator of cardiac performance. To what extent the change in E(A) during exercise impacts on cardiac performance and aerobic capacity is unknown. We examined E(A) and its relationship with cardiovascular performance in 352 healthy subjects. Subjects underwent rest and exercise gated scans to measure cardiac volumes and to derive E(A)[end-systolic pressure/stroke volume index(SV)], PVR[MAP/(SV*HR)], and TAC(SV/pulse pressure). E(A) varied with exercise intensity: the ΔE(A) between rest and peak exercise along with its determinants, differed among individuals and ranged from -44% to +149%, and was independent of age and sex. Individuals were separated into 3 groups based on their ΔE(A)I. Individuals with the largest increase in ΔE(A)(group 3;ΔE(A)≥0.98 mmHg.m(2)/ml) had the smallest reduction in PVR, the greatest reduction in TAC and a similar increase in HR vs. group 1(ΔE(A)<0.22 mmHg.m(2)/ml). Furthermore, group 3 had a reduction in end-diastolic volume, and a blunted increase in SV(80%), and cardiac output(27%), during exercise vs. group 1. Despite limitations in the Frank-Starling mechanism and cardiac function, peak aerobic capacity did not differ by group because arterial-venous oxygen difference was greater in group 3 vs. 1. Thus the change in arterial load during exercise has important effects on the Frank-Starling mechanism and cardiac performance but not on exercise capacity. These findings provide interesting insights into the dynamic cardiovascular alterations during exercise.

  5. Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial load

    Science.gov (United States)

    Chantler, Paul D.; Melenovsky, Vojtech; Schulman, Steven P.; Gerstenblith, Gary; Becker, Lewis C.; Ferrucci, Luigi; Fleg, Jerome L.; Najjar, Samer S.

    2012-01-01

    Effective arterial elastance(EA) is a measure of the net arterial load imposed on the heart that integrates the effects of heart rate(HR), peripheral vascular resistance(PVR), and total arterial compliance(TAC) and is a modulator of cardiac performance. To what extent the change in EA during exercise impacts on cardiac performance and aerobic capacity is unknown. We examined EA and its relationship with cardiovascular performance in 352 healthy subjects. Subjects underwent rest and exercise gated scans to measure cardiac volumes and to derive EA[end-systolic pressure/stroke volume index(SV)], PVR[MAP/(SV*HR)], and TAC(SV/pulse pressure). EA varied with exercise intensity: the ΔEA between rest and peak exercise along with its determinants, differed among individuals and ranged from −44% to +149%, and was independent of age and sex. Individuals were separated into 3 groups based on their ΔEAI. Individuals with the largest increase in ΔEA(group 3;ΔEA≥0.98 mmHg.m2/ml) had the smallest reduction in PVR, the greatest reduction in TAC and a similar increase in HR vs. group 1(ΔEAexercise vs. group 1. Despite limitations in the Frank-Starling mechanism and cardiac function, peak aerobic capacity did not differ by group because arterial-venous oxygen difference was greater in group 3 vs. 1. Thus the change in arterial load during exercise has important effects on the Frank-Starling mechanism and cardiac performance but not on exercise capacity. These findings provide interesting insights into the dynamic cardiovascular alterations during exercise. PMID:22003052

  6. Effect of volume loading on the Frank-Starling relation during reductions in central blood volume in heat-stressed humans

    DEFF Research Database (Denmark)

    Bundgaard-Nielsen, Morten; Wilson, T E; Seifert, Thomas

    2010-01-01

    During reductions in central blood volume while heat stressed, a greater decrease in stroke volume (SV) for a similar decrease in ventricular filling pressure, compared to normothermia, suggests that the heart is operating on a steeper portion of a Frank-Starling curve. If so, volume loading of h...

  7. A Mutation in the Glutamate-rich Region of RBM20 Causes Dilated Cardiomyopathy through Missplicing of Titin and Impaired Frank-Starling Mechanism

    DEFF Research Database (Denmark)

    Beqqali, Abdelaziz; Bollen, Ilse A E; Rasmussen, Torsten B;

    2016-01-01

    analysis revealed a dramatic shift from the less compliant N2B towards the highly compliant N2BA isoforms in RBM20(E913K/+) heart. Moreover, an increased sarcomere resting-length was observed in single cardiomyocytes and isometric force measurements revealed an attenuated Frank-Starling mechanism (FSM...

  8. Post Occupancy energy evaluation of Ronald Tutor Hall using eQUEST; Computer based simulation of existing building and comparison of data

    Science.gov (United States)

    Dulom, Duyum

    Buildings account for about 40 percent of total U.S. energy consumption. It is therefore important to shift our focus on important measures that can be taken to make buildings more energy efficient. With the rise in number of buildings day by day and the dwindling resources, retrofitting buildings is the key to an energy efficiency future. Post occupancy evaluation (POE) is an important tool and is ideal for the retrofitting process. POE would help to identify the problem areas in the building and enable researchers and designers to come up with solutions addressing the inefficient energy usage as well as the overall wellbeing of the users of the building. The post occupancy energy evaluation of Ronald Tutor Hall (RTH) located at the University of Southern California is one small step in that direction. RTH was chosen to study because; (a) relatively easy access to the building data (b) it was built in compliance with Title 24 2001 and (c) it was old enough to have post occupancy data. The energy modeling tool eQuest was used to simulate the RTH building using the background information of the building such as internal thermal comfort profile, occupancy profile, building envelope profile, internal heat gain profile, etc. The simulation results from eQuest were then compared with the actual building recorded data to verify that our simulated model was behaving similar to the actual building. Once we were able to make the simulated model behave like the actual building, changes were made to the model such as installation of occupancy sensor in the classroom & laboratories, changing the thermostat set points and introducing solar shade on northwest and southwest facade. The combined savings of the proposed interventions resulted in a 6% savings in the overall usage of energy.

  9. Assessment of current burden of human rabies at Sir Ronald Ross Institute of Tropical and Communicable Diseases (Government Fever Hospital – Five year study

    Directory of Open Access Journals (Sweden)

    Dukkipati Kalyani

    2017-01-01

    Full Text Available Human rabies has been still endemic in India. There are an increasing number of studies estimating the burden of human rabies, but the true incidence of the disease and endemicity were rarely reported in the literature. The main objectives of the present study were to determine the endemicity and to estimate the current burden of human rabies in and around Sir Ronald Ross Institute of Tropical and Communicable Diseases (SRRIT & CD, Nallakunta, Hyderabad. All cases admitted at SRRIT & CD with signs and symptoms of rabies were studied during the period of January 2009 and December 2013. The annual incidence of human rabies in this hospital was estimated to be 152. It is endemic mainly in urban areas that include many areas in Hyderabad and Secunderabad and also adjacent districts. The majority of the patients were children and adult male, from urban areas, and had not taken post exposure prophylaxis (PEP i.e. wound care, active immunization (ARV and passive immunization (RIG. The main animals responsible for bites were dogs (99%, most of which were stray and the most common bite sites were the extremities. Most common clinical feature was hydrophobia. About 92.76% of these patients had not taken PEP. Human rabies continues to be a dreadful disease in India and the dogs are the principal reservoir, mainly stray dogs. This study provides strong evidence that human rabies is still an endemic disease even in urban areas. This is mainly due to lack of awareness about proper PEP. Improved coverage with modern rabies vaccines, control of rabies due to dogs and other animals and intensifying public education about the disease play main role in the reduction of the disease. [J Med Allied Sci 2017; 7(1.000: 14-19

  10. On Teaching International Courses on Health Information Systems. Lessons Learned during 16 Years of Frank - van Swieten Lectures on Strategic Information Management in Health Information Systems.

    Science.gov (United States)

    Ammenwerth, Elske; Knaup, Petra; Winter, Alfred; Bauer, Axel W; Bott, Oliver J; Gietzelt, Matthias; Haarbrandt, Birger; Hackl, Werner O; Hellrung, Nils; Hübner-Bloder, Gudrun; Jahn, Franziska; Jaspers, Monique W; Kutscha, Ulrike; Machan, Christoph; Oppermann, Bianca; Pilz, Jochen; Schwartze, Jonas; Seidel, Christoph; Slot, Jan-Eric; Smers, Stefan; Spitalewsky, Katharina; Steckel, Nathalie; Strübing, Alexander; van der Haak, Minne; Haux, Reinhold; Ter Burg, Willem J

    2017-03-08

    Health information systems (HIS) are one of the most important areas for biomedical and health informatics. In order to professionally deal with HIS well-educated informaticians are needed. Because of these reasons, in 2001 an international course has been established: The Frank - van Swieten Lectures on Strategic Information Management of Health Information Systems. Reporting about the Frank - van Swieten Lectures and about our students' feedback on this course during the last 16 years. Summarizing our lessons learned and making recommendations for such international courses on HIS. The basic concept of the Frank - van Swieten lectures is to teach the theoretical background in local lectures, to organize practical exercises on modelling sub-information systems of the respective local HIS and finally to conduct Joint Three Days as an international meeting were the resulting models are introduced and compared. During the last 16 years, the Universities of Amsterdam, Braunschweig, Heidelberg/Heilbronn, Leipzig as well as UMIT were involved in running this course. Overall, 517 students from these universities participated. Our students' feedback was clearly positive. The Joint Three Days of the Frank - van Swieten Lectures, where at the end of the course all students can meet, turned out to be an important component of this course. Based on the last 16 years, we recommend common teaching materials, agreement on equivalent clinical areas for the exercises, support of group building of international student groups, motivation of using a collaboration platform, ensuring quality management of the course, addressing different levels of knowledge of the students, and ensuring sufficient funding for joint activities. Although associated with considerable additional efforts, we can clearly recommend establishing such international courses on HIS, such as the Frank - van Swieten Lectures.

  11. The 'pay ratio' provision of the Dodd-Frank Act 2010 and presentation of the Paulo–Le Roux Index

    Directory of Open Access Journals (Sweden)

    Stanley Paulo

    2016-02-01

    Full Text Available Orientation: This article addresses the issues of executive remuneration and whether it was excessive or not.Research purpose: On 05 August 2015, the US Securities and Exchange Commission (SEC adopted a rule to operationalise Section 953(b of the Dodd-Frank Wall Street Reform and Consumer Protection Act 2010 (Dodd-Frank or the Dodd-Frank Act 2010, the ‘pay ratio provision’, as part of a process to ensure sound corporate governance and shed light on assertions that corporate executive remuneration was excessive and detrimental to the economic wellbeing of the USA. This pay ratio rule will be operative starting from 2017 and requires public firms to publish the ratio of chief executive officer (CEO remuneration to the median remuneration of all its employees. Hence, it is a measure of income distribution. It does not reveal the relationship between executive compensation and the value added to the firm by executives. In anticipation of this rule becoming mandatory and as part of a quest to quantify the value of executives to the firm, Paulo and Le Roux (2014 developed an approach to measure the value executives add to the firm, drawing from audited financial statements and thereby demonstrating that the value added by executive management could be measured according to the requirements of sound research methodology and rigorous epistemology.Motivation for the study: Statutory enactment of the pay ratio provision provided the impetus to create an index, the Paulo–Le Roux Index, that shows how much executives are paid in relation to how much value they add to the firm.Research design, approach and method: Paulo and Le Roux (2014 developed an approach to measure the value executives add to the firm, drawing from audited financial statements and thereby demonstrating that the value added by executive management could be measured according to the requirements of sound research methodology and rigorous epistemology. Statutory enactment of the pay

  12. Não verás país nenhum: literatura e cultura brasileira em Ronald de Carvalho e João Cezar de Castro Rocha

    OpenAIRE

    Rocha, Marcelo

    2012-01-01

    O percurso teórico que norteia a elaboração desse artigo busca aproximar a organização de histórias da literatura desde a primeira metade do século XX, em especial o trabalho de Ronald de Carvalho, em sua Pequena história da literatura brasileira, de 1919, até os pressupostos orientadores da estrutura estabelecida por João Cezar de Castro Rocha, em Nenhum Brasil existe: pequena enciclopédia, de 2003.

  13. Não verás país nenhum: literatura e cultura brasileira em Ronald de Carvalho e João Cezar de Castro Rocha

    OpenAIRE

    Rocha, Marcelo

    2012-01-01

    O percurso teórico que norteia a elaboração desse artigo busca aproximar a organização de histórias da literatura desde a primeira metade do século XX, em especial o trabalho de Ronald de Carvalho, em sua Pequena história da literatura brasileira, de 1919, até os pressupostos orientadores da estrutura estabelecida por João Cezar de Castro Rocha, em Nenhum Brasil existe: pequena enciclopédia, de 2003.

  14. Oxygenated fraction and mass of organic aerosol from direct emission and atmospheric processing measured on the R/V Ronald Brown during TEXAQS/GoMACCS 2006

    Science.gov (United States)

    Russell, L. M.; Takahama, S.; Liu, S.; Hawkins, L. N.; Covert, D. S.; Quinn, P. K.; Bates, T. S.

    2009-04-01

    Submicron particles collected on Teflon filters aboard the R/V Ronald Brown during the Texas Air Quality Study and Gulf of Mexico Atmospheric Composition and Climate Study (TexAQS/GoMACCS) 2006 in and around the port of Houston, Texas, were measured by Fourier transform infrared (FTIR) and X-ray fluorescence for organic functional groups and elemental composition. Organic mass (OM) concentrations (1-25 μg m-3) for ambient particle samples measured by FTIR showed good agreement with measurements made with an aerosol mass spectrometer. The fractions of organic mass identified as alkane and carboxylic acid groups were 47% and 32%, respectively. Three different types of air masses were identified on the basis of the air mass origin and the radon concentration, with significantly higher carboxylic acid group mass fractions in air masses from the north (35%) than the south (29%) or Gulf of Mexico (26%). Positive matrix factorization analysis attributed carboxylic acid fractions of 30-35% to factors with mild or strong correlations (r > 0.5) to elemental signatures of oil combustion and 9-24% to wood smoke, indicating that part of the carboxylic acid fraction of OM was formed by the same sources that controlled the metal emissions, namely the oil and wood combustion activities. The implication is that a substantial part of the measured carboxylic acid contribution was formed independently of traditionally "secondary" processes, which would be affected by atmospheric (both photochemical and meteorological) conditions and other emission sources. The carboxylic acid group fractions in the Gulf of Mexico and south air masses (GAM and SAM, respectively) were largely oil combustion emissions from ships as well as background marine sources, with only limited recent land influences (based on radon concentrations). Alcohol groups accounted for 14% of OM (mostly associated with oil combustion emissions and background sources), and amine groups accounted for 4% of OM in all air

  15. Aerosol Optical Properties Measured Onboard the Ronald H. Brown During ACE Asia as a Function of Aerosol Chemical Composition and Source Region

    Science.gov (United States)

    Quinn, P. K.; Coffman, D. J.; Bates, T. S.; Welton, E. J.; Covert, D. S.; Miller, T. L.; Johnson, J. E.; Maria, S.; Russell, L.; Arimoto, R.

    2004-01-01

    During the ACE Asia intensive field campaign conducted in the spring of 2001 aerosol properties were measured onboard the R/V Ronald H. Brown to study the effects of the Asian aerosol on atmospheric chemistry and climate in downwind regions. Aerosol properties measured in the marine boundary layer included chemical composition; number size distribution; and light scattering, hemispheric backscattering, and absorption coefficients. In addition, optical depth and vertical profiles of aerosol 180 deg backscatter were measured. Aerosol within the ACE Asia study region was found to be a complex mixture resulting from marine, pollution, volcanic, and dust sources. Presented here as a function of air mass source region are the mass fractions of the dominant aerosol chemical components, the fraction of the scattering measured at the surface due to each component, mass scattering efficiencies of the individual components, aerosol scattering and absorption coefficients, single scattering albedo, Angstrom exponents, optical depth, and vertical profiles of aerosol extinction. All results except aerosol optical depth and the vertical profiles of aerosol extinction are reported at a relative humidity of 55 +/- 5%. An over-determined data set was collected so that measured and calculated aerosol properties could be compared, internal consistency in the data set could be assessed, and sources of uncertainty could be identified. By taking into account non-sphericity of the dust aerosol, calculated and measured aerosol mass and scattering coefficients agreed within overall experimental uncertainties. Differences between measured and calculated aerosol absorption coefficients were not within reasonable uncertainty limits, however, and may indicate the inability of Mie theory and the assumption of internally mixed homogeneous spheres to predict absorption by the ACE Asia aerosol. Mass scattering efficiencies of non-sea salt sulfate aerosol, sea salt, submicron particulate organic

  16. Large reduction in the magnitude and thermal variation of Frank elastic constants in a gold nanorod/nematic composite

    Science.gov (United States)

    Lakshmi Madhuri, P.; Krishna Prasad, S.; Shinde, Pravin; Prasad, B. L. V.

    2016-10-01

    We report measurements of splay and bend Frank elastic constants in a composite comprising a nematic liquid crystal doped with a small concentration of sterically stabilized gold nanorods. The composite exhibits not only a large reduction in the magnitude of the threshold voltage for switching (V th, 20%), as well as of the splay (K 11, 40%) and bend (K 33, 40%) elastic constants, but also presents an unprecedented feature: a substantial diminution in the temperature dependence of these parameters, almost to the point of becoming thermally invariant. This observation is significant because the electro-optic switching of liquid-crystal devices is largely controlled by the K 11 and K 33 elastic constants. Electrical conductivity measurements also show interesting behavior upon the inclusion of nanorods. Whereas the intrinsic Arrhenius behavior governing the temperature dependence is enhanced, the frequency dependence shows qualitative features of Jonscher’s universal model, albeit with a higher exponent. Further, photoisomerization of an azobenzene guest component provides an additional influence on the elastic constants. The results are discussed in terms of (a) the effect of the order parameter dependence seen from the viewpoint of an extended mean-field model, and (b) local order. The advantage of incorporating nanorods with photofunctionality is also pointed out.

  17. Effects of Interaction Between Ventricular Assist Device Assistance and Autoregulated Mock Circulation Including Frank-Starling Mechanism and Baroreflex.

    Science.gov (United States)

    Jansen-Park, So-Hyun; Mahmood, Mohammad Nauzef; Müller, Indra; Turnhoff, Lisa Kathrin; Schmitz-Rode, Thomas; Steinseifer, Ulrich; Sonntag, Simon Johannes

    2016-10-01

    A mock heart circulation loop (MHCL) is a hydraulic model simulating the human circulatory system. It allows in vitro investigations of the interaction between cardiac assist devices and the human circulatory system. In this study, a preload sensitive MHCL, the MHCLAUTO , was developed to investigate the interaction between the left ventricle and left ventricular assist devices (LVADs). The Frank-Starling mechanism was modeled by regulating the stroke volume (SV) based on the measured mean diastolic left atrial pressure (MLAPdiast ). The baroreflex autoregulation mechanism was implemented to maintain a constant mean aortic pressure (MAP) by varying ventricular contractility (Emax ), heart rate (HR), afterload/systemic vascular resistance (SVR) and unstressed venous volume (UVV). The DP3 blood pump (Medos Medizintechnik GmbH) was used to simulate the LVAD. Characteristic parameters were measured in pathological conditions both with and without LVAD to assess the hemodynamic effect of LVAD on the MHCLAUTO . The results obtained from the MHCLAUTO show a high correlation to literature data. The study demonstrates the possibility of using the MHCLAUTO as a research tool to better understand the physiological interactions between cardiac implants and human circulation.

  18. Effect of volume loading on the Frank-Starling relation during reductions in central blood volume in heat-stressed humans

    DEFF Research Database (Denmark)

    Bundgaard-Nielsen, Morten; Wilson, T E; Seifert, Thomas

    2010-01-01

    During reductions in central blood volume while heat stressed, a greater decrease in stroke volume (SV) for a similar decrease in ventricular filling pressure, compared to normothermia, suggests that the heart is operating on a steeper portion of a Frank-Starling curve. If so, volume loading...... of heat-stressed individuals would shift the operating point to a flatter portion of the heat stress Frank-Starling curve thereby attenuating the reduction in SV during subsequent decreases in central blood volume. To investigate this hypothesis, right heart catheterization was performed in eight males.......06). However, subsequent volume loading increased SV to 143 +/- 29 ml (P = 0.003). LBNP provoked a larger decrease in SV relative to the decrease in PCWP during heating (8.6 +/- 1.9 ml mmHg(1)) compared to normothermia (4.5 +/- 3.0 ml mmHg(1), P = 0.02). After volume loading while heat stressed, the reduction...

  19. From the Disordered State to the Frank-Kasper Sigma Phase: Readily Tuning the Phase Behavior of Block Polymers via Lithium Salt Addition

    Science.gov (United States)

    Irwin, Matthew; Hickey, Robert; Bates, Frank; Lodge, Timothy

    Sphere-forming block copolymers have long been known to assemble onto a body-centered cubic (BCC) lattice, but recent work has demonstrated that with the correct thermal treatments, more exotic morphologies such as dodecagonal quasicrystals or the Frank-Kasper sigma phase can be observed. In this presentation, we show that a similar variety of morphologies can be obtained by simply adding small amounts of lithium bis(trifluoromethane)sulfonimide (LiTFSI), which preferentially partitions into one of the domains. Using small-angle X-ray scattering, we have found that block copolymers, which are disordered when neat, can form spheres with liquid-like packing, BCC crystals, the Frank-Kasper sigma phase, or hexagonally close packed crystals upon increasing the salt loading. This work demonstrates a unique, alternative route to highly segregated sphere-forming block copolymers and examines the universality of the formation of these complex morphologies.

  20. Wi-Fi联盟最新进展报告——访Wi-Fi联盟总经理Frank Hanzlik

    Institute of Scientific and Technical Information of China (English)

    高威

    2006-01-01

    06年1月20日,Wi—Fi联盟董事总经理Frank Hanzlik先生来华进行访问。据称,Frank此次来华的目的在于访问Wi—Fi在北京的实验室,与联盟成员进行进一步的沟通,并且拜访一些将来可能加入Wi—Fi联盟的成员。

  1. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from underway - surface observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from NOAA Ship RONALD H. BROWN in the Caribbean Sea, North Atlantic Ocean and South Atlantic Ocean from 2011-07-22 to 2011-12-06 (NODC Accession 0108094)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0108094 includes chemical, meteorological, physical and underway - surface data collected from NOAA Ship RONALD H. BROWN in the Caribbean Sea, North...

  2. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from underway - surface observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from NOAA Ship RONALD H. BROWN in the Gulf of Guinea, Gulf of Mexico and others from 2010-03-08 to 2010-12-20 (NODC Accession 0108093)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0108093 includes chemical, meteorological, physical and underway - surface data collected from NOAA Ship RONALD H. BROWN in the Gulf of Guinea, Gulf...

  3. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from underway - surface observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from NOAA Ship RONALD H. BROWN in the Caribbean Sea, Gulf of Mexico and others from 2009-04-17 to 2009-10-18 (NODC Accession 0109931)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0109931 includes biological, chemical, meteorological, physical and underway - surface data collected from NOAA Ship RONALD H. BROWN in the Caribbean...

  4. Dissolved inorganic carbon, total alkalinity, pH, fugacity of carbon dioxide, and other variables from surface observations using Niskin bottle, flow through pump and other instruments from NOAA Ship Ronald H. Brown in the Gulf of Mexico and East Coast of the United States during the second Gulf of Mexico and East Coast Carbon (GOMECC-2) Cruise from 2012-07-22 to 2012-08-13 (NODC Accession 0117971)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This archival package contains ocean acidification related data from the the second Gulf of Mexico and East Coast Carbon (GOMECC-2) Cruise on board NOAA Ship Ronald...

  5. Partial pressure (or fugacity) of carbon dioxide, dissolved inorganic carbon, pH, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using Alkalinity titrator, Barometric pressure sensor and other instruments from NOAA Ship RONALD H. BROWN in the South Atlantic Ocean, South Pacific Ocean and Southern Oceans from 2005-01-11 to 2005-02-24 (NODC Accession 0108153)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0108153 includes discrete sample and profile data collected from NOAA Ship RONALD H. BROWN in the South Atlantic Ocean, South Pacific Ocean and...

  6. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from underway - surface observations using Carbon dioxide (CO2) gas analyzer, Shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement and other instruments from NOAA Ship RONALD H. BROWN in the North Atlantic Ocean and Stellwagen Bank National Marine Sanctuary from 2012-02-15 to 2012-08-27 (NODC Accession 0109926)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0109926 includes chemical, meteorological, physical and underway - surface data collected from NOAA Ship RONALD H. BROWN in the North Atlantic Ocean...

  7. Testing of Frank's hypothesis on a containerless packing of macroscopic soft spheres and comparison with mono-atomic metallic liquids

    Energy Technology Data Exchange (ETDEWEB)

    Sahu, K.K., E-mail: kisor.sahu@mat.ethz.ch [Laboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, 8093 Zurich (Switzerland); Wessels, V. [Laboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, 8093 Zurich (Switzerland); Kelton, K.F. [Department of Physics, Washington University, St. Louis, Missouri 63130 (United States); Loeffler, J.F. [Laboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, 8093 Zurich (Switzerland)

    2011-06-15

    Highlights: > Testing of Frank's hypothesis for Centripetal Packing (CP) has been proposed. > It is shown that CP is an idealized model for Monatomic Supercooled Liquid (MSL). > The CP is fit for comparing with studies on MSL in a containerless environment. > We measure local orders in CP by HA and BOO methods for the first time. > It is shown that icosahedral order is greater in CP than MSL and reasons explored. - Abstract: It is well-known that metallic liquids can exist below their equilibrium melting temperature for a considerable time. To explain this, Frank proposed that icosahedral ordering, incompatible with crystalline long-range order, is prevalent in the atomic structure of these liquids, stabilizing them and enabling them to be supercooled. Some studies of the atomic structures of metallic liquids using Beam-line Electrostatic Levitation (BESL; containerless melting), and other techniques, support this hypothesis . Here we examine Frank's hypothesis in a system of macroscopic, monodisperse deformable spheres obtained by containerless packing under the influence of centripetal force. The local structure of this packing is analyzed and compared with atomic ensembles of liquid transition metals obtained by containerless melting using the BESL method.

  8. USARSKI, Frank. O Budismo e as outras: Encontros e desencontros entre as grandes religiões mundiais. Aparecida: Ideias & Letras, 2009. 304p. ISBN 978-85-7698-053-7

    Directory of Open Access Journals (Sweden)

    Elisangela Marina de Freitas e Silva

    2012-01-01

    Full Text Available Resenha do livro USARSKI, Frank. O Budismo e as outras: Encontros e desencontros entre as grandes religiões mundiais. Aparecida: Ideias & Letras, 2009. 304p.ISBN 978-85-7698-053-7

  9. Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work.

    Science.gov (United States)

    Glower, D D; Spratt, J A; Snow, N D; Kabas, J S; Davis, J W; Olsen, C O; Tyson, G S; Sabiston, D C; Rankin, J S

    1985-05-01

    The Frank-Starling relationship generally has been examined with filling pressure as the index of preload, resulting in a curvilinear function that plateaus at higher filling pressures. To investigate this relationship further in the intact heart, 32 dogs were chronically instrumented with left ventricular and pleural micromanometers and with regional (10 dogs) or global (22 dogs) ultrasonic dimension transducers. Seven days after implantation, left ventricular pressure and regional or global dimensions were recorded in the conscious state. After autonomic blockade, preload was varied by vena caval occlusion. Myocardial function was assessed by calculating regional or global stroke work, and preload was measured as end-diastolic segment length or chamber volume. The relationship between stroke work and either end-diastolic segment length or chamber volume (termed the preload recruitable stroke work relationship) was highly linear in every study (mean r = .97) and could be quantified by a slope (MW) and x-intercept (LW). Previous nonlinear relationships between stroke work and filling pressure seemed to reflect the exponential diastolic pressure-volume curve. Over the physiologic range of systolic arterial pressures produced by infusion of nitroprusside or phenylephrine, no significant change was observed in MW or LW in the normal dog. Calcium infusion increased both regional and global MW by 71 +/- 19% and 65 +/- 9%, respectively (p less than .02), with no significant change in LW. To normalize for ventricular geometry and heart rate, stroke work was computed from circumferential stress-strain data and converted to myocardial power output, which was then plotted against end-diastolic circumferential strain. This relationship also was highly linear, and the slope, Mmp (mW/cm3 of myocardium), is proposed as a potential measure of intrinsic myocardial performance independent of loading, geometry, and heart rate.

  10. Dissolved oxygen, temperature, salinity, and other variables measured from profile observations using CTD and other instruments from NOAA Ship Ronald H. Brown in the East Coast of the United States and Gulf of Mexico during the second Gulf of Mexico and East Coast Carbon (GOMECC-2) Cruise from 2012-07-24 to 2012-08-13 (NODC Accession 0117943)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The second Gulf of Mexico and East Coast Carbon (GOMECC-2) Cruise on board NOAA Ship Ronald H. Brown from Miami, took place in the Gulf of Mexico and then along the...

  11. Temperature and salinity profiles from CTD casts from NOAA Ship RONALD H. BROWN and NOAA Ship KA'IMIMOANA in the NE and SW Pacific as part of the Global Ocean-Atmosphere-Land System (GOALS) / Pan American Climate Studies (PACS) from 2001-01-14 to 2001-12-05 (NODC Accession 0000658)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from NOAA Ship RONALD H. BROWN and NOAA Ship KA'IMIMOANA in the NE and SW Pacific from 14 January 2001 to 05 December 2001. CTD...

  12. Temperature and salinity profiles from CTD casts from NOAA Ship RONALD H. BROWN in the SE Pacific (limit -140 W) as part of the East Pacific Investigations of Climate Processes in the Coupled Ocean-Atmosphere from 2001-02-01 to 2001-03-08 (NODC Accession 0000660)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD and other data were collected from NOAA Ship RONALD H. BROWN in the SE Pacific (limit-140 W) from from 01 February 2001 to 08 March 2001. CTD data consist of...

  13. Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region deficient mice

    Science.gov (United States)

    Lee, Eun-Jeong; Peng, Jun; Radke, Michael; Gotthardt, Michael; Granzier, Henk L

    2010-01-01

    Previous work suggests that titin-based passive tension is a factor in the Frank-Starling mechanism of the heart, by increasing length-dependent activation (LDA) through an increase in calcium sensitivity at long sarcomere length. We tested this hypothesis in a mouse model (N2B KO model) in which titin-based passive tension is elevated as a result of the excision of the N2B element, one of cardiac titin’s spring elements. LDA was assessed by measuring the active tension-pCa (−log[Ca2+]) relationship at sarcomere length (SLs) of 1.95, 2.10 and 2.30 µm in WT and N2B KO skinned myocardium. LDA was positively correlated with titin-based passive tension, due to an increase in calcium sensitivity at the longer SLs in the KO. For example, at pCa 6.0 the KO:WT tension ratio was 1.28 ± 0.07 and 1.42 ± 0.04 at SLs of 2.1 and 2.3 µm, respectively. There was no difference in protein expression or phosphorylation of sarcomeric proteins. We also measured the calcium sensitivity after PKA treating the skinned muscle and found that titin-based passive tension was also now correlated with LDA, with a slope that was significantly increased compared to no PKA treatment. Finally, we performed isolated heart experiments and measured the Frank-Starling relation (slope of developed wall stress-LV volume relation) as well as diastolic stiffness (slope of diastolic wall stress – volume relation). The FSM was more pronounced in the N2B KO hearts and the slope of the FSM correlated with diastolic stiffness. These findings support that titin-based passive tension triggers an increase in calcium sensitivity at long sarcomere length, thereby playing an important role in the Frank-Starling mechanism of the heart. PMID:20507834

  14. Regulatory mechanism of length-dependent activation in skinned porcine ventricular muscle: role of thin filament cooperative activation in the Frank-Starling relation.

    Science.gov (United States)

    Terui, Takako; Shimamoto, Yuta; Yamane, Mitsunori; Kobirumaki, Fuyu; Ohtsuki, Iwao; Ishiwata, Shin'ichi; Kurihara, Satoshi; Fukuda, Norio

    2010-10-01

    Cardiac sarcomeres produce greater active force in response to stretch, forming the basis of the Frank-Starling mechanism of the heart. The purpose of this study was to provide the systematic understanding of length-dependent activation by investigating experimentally and mathematically how the thin filament "on-off" switching mechanism is involved in its regulation. Porcine left ventricular muscles were skinned, and force measurements were performed at short (1.9 µm) and long (2.3 µm) sarcomere lengths. We found that 3 mM MgADP increased Ca(2+) sensitivity of force and the rate of rise of active force, consistent with the increase in thin filament cooperative activation. MgADP attenuated length-dependent activation with and without thin filament reconstitution with the fast skeletal troponin complex (sTn). Conversely, 20 mM of inorganic phosphate (Pi) decreased Ca(2+) sensitivity of force and the rate of rise of active force, consistent with the decrease in thin filament cooperative activation. Pi enhanced length-dependent activation with and without sTn reconstitution. Linear regression analysis revealed that the magnitude of length-dependent activation was inversely correlated with the rate of rise of active force. These results were quantitatively simulated by a model that incorporates the Ca(2+)-dependent on-off switching of the thin filament state and interfilament lattice spacing modulation. Our model analysis revealed that the cooperativity of the thin filament on-off switching, but not the Ca(2+)-binding ability, determines the magnitude of the Frank-Starling effect. These findings demonstrate that the Frank-Starling relation is strongly influenced by thin filament cooperative activation.

  15. Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice.

    Science.gov (United States)

    Lee, Eun-Jeong; Peng, Jun; Radke, Michael; Gotthardt, Michael; Granzier, Henk L

    2010-09-01

    Previous work suggests that titin-based passive tension is a factor in the Frank-Starling mechanism of the heart, by increasing length-dependent activation (LDA) through an increase in calcium sensitivity at long sarcomere length. We tested this hypothesis in a mouse model (N2B KO model) in which titin-based passive tension is elevated as a result of the excision of the N2B element, one of cardiac titin's spring elements. LDA was assessed by measuring the active tension-pCa (-log[Ca(2+)]) relationship at sarcomere length (SLs) of 1.95, 2.10, and 2.30 microm in WT and N2B KO skinned myocardium. LDA was positively correlated with titin-based passive tension due to an increase in calcium sensitivity at the longer SLs in the KO. For example, at pCa 6.0, the KO:WT tension ratio was 1.28+/-0.07 and 1.42+/-0.04 at SLs of 2.1 and 2.3 microm, respectively. There was no difference in protein expression or total phosphorylation of sarcomeric proteins. We also measured the calcium sensitivity after PKA treating the skinned muscle and found that titin-based passive tension was also now correlated with LDA, with a slope that was significantly increased compared to no PKA treatment. Finally, we performed isolated heart experiments and measured the Frank-Starling relation (slope of developed wall stress-LV volume relation) as well as diastolic stiffness (slope of diastolic wall stress-volume relation). The FSM was more pronounced in the N2B KO hearts and the slope of the FSM correlated with diastolic stiffness. These findings support that titin-based passive tension triggers an increase in calcium sensitivity at long sarcomere length, thereby playing an important role in the Frank-Starling mechanism of the heart.

  16. Red de Monitoreo Ambiental de las aguas interiores en la camaronera "Guajaca", Frank País. Holguín

    Directory of Open Access Journals (Sweden)

    Sara Fernández Cruz

    2008-01-01

    Full Text Available Se presenta la proyección y diseño de una red de monitoreo con el propósito fundamental de valorar, observar y controlar el recurso natural agua, tanto interiores como marinas, así como el arrecife costero, para su protección, conservación y mejoramiento, ante el impacto que pueda producir sobre las mismas la construcción y explotación de la "Camaronera Guajaca", ubicada al Este de la provincia Holguín, en el municipio Frank País.

  17. New Times, New Heroes : Ambiguity, Socio-Political Issues and Post Modernism in Frank Miller's Graphic Novel The Dark Knight Returns

    OpenAIRE

    Axelsson, Jan

    2013-01-01

    Frank Miller’s The Dark Knight Returns is one of the first graphic novels to redraw the map for this kind of literature but perhaps first and foremost for the characteristics of superheroes and villains. It is a story which we have read before in the sense that Batman, the eternal crime fighter, chases his arch enemies Two Face and the Joker, but it is also a new story in which we meet an ambiguous and complex superhero. Batman has become an old man tormented by his past, in which his side ki...

  18. A Zuni Artist looks at Frank Hamilton Cushing: Cartoons by Phil Hughte, Pueblo of Zuni Arts and Crafts, Zuni, New Mexico

    Directory of Open Access Journals (Sweden)

    Douglas R. Givens

    1996-05-01

    Full Text Available This book is a very unique look into the legacy of Frank Hamilton Cushing at Zuni and his influence on the Zuni people by the Zuni cartoonist Phil Hughte. This volume of Hughte's cartoons depicts Cushing at various periods and important moments of his career at Zuni. Although Hughte's cartoons selected Cushing moments at Zuni require no words to express Cushing's influence on the pueblo, Hughte provides captions to each of his cartoons designed to explain what Cushing was doing to the reader who is not intimately knowledgeable about Cushing's work.

  19. Topic for writing:Friendly Enemies——Character analysis of Frank O' Conner's short story of Guest of the Nation

    Institute of Scientific and Technical Information of China (English)

    王韬

    2006-01-01

    Patricia Robinson once said, "in war, hatred and revenge drive out ethical and moral intelligence."The short story of "Guest of the Nation", written by FrankO'Connor's, well confirms such a viewpoint towards war, which is still prevalent in today's world. This article,based upon character analysis of the story which is full of conflict all the way through character images, plot arrangements as well as story settings, aims to arouse readers'further thinking over absurdity of war and value of humanity.

  20. Effect of volume loading on the Frank-Starling relation during reductions in central blood volume in heat-stressed humans.

    Science.gov (United States)

    Bundgaard-Nielsen, M; Wilson, T E; Seifert, T; Secher, N H; Crandall, C G

    2010-09-01

    During reductions in central blood volume while heat stressed, a greater decrease in stroke volume (SV) for a similar decrease in ventricular filling pressure, compared to normothermia, suggests that the heart is operating on a steeper portion of a Frank-Starling curve. If so, volume loading of heat-stressed individuals would shift the operating point to a flatter portion of the heat stress Frank-Starling curve thereby attenuating the reduction in SV during subsequent decreases in central blood volume. To investigate this hypothesis, right heart catheterization was performed in eight males from whom pulmonary capillary wedge pressure (PCWP), central venous pressure and SV (via thermodilution) were obtained while central blood volume was reduced via lower-body negative pressure (LBNP) during normothermia, whole-body heating (increase in blood temperature 1 degrees C), and during whole-body heating after intravascular volume expansion. Volume expansion was accomplished by administration of a combination of a synthetic colloid (HES 130/0.4, Voluven) and saline. Before LBNP, SV was not affected by heating (122 +/- 30 ml; mean +/- s.d.) compared to normothermia (110 +/- 20 ml; P = 0.06). However, subsequent volume loading increased SV to 143 +/- 29 ml (P = 0.003). LBNP provoked a larger decrease in SV relative to the decrease in PCWP during heating (8.6 +/- 1.9 ml mmHg(1)) compared to normothermia (4.5 +/- 3.0 ml mmHg(1), P = 0.02). After volume loading while heat stressed, the reduction in the SV to PCWP ratio during LBNP was comparable to that observed during normothermia (4.8 +/- 2.3 ml mmHg(1); P = 0.78). These data support the hypothesis that a Frank-Starling mechanism contributes to compromised blood pressure control during simulated haemorrhage in heat-stressed individuals, and extend those findings by showing that volume infusion corrects this deficit by shifting the operating point to a flatter portion of the heat stress Frank-Starling curve.

  1. The role of the Frank-Starling law in the transduction of cellular work to whole organ pump function: a computational modeling analysis.

    Directory of Open Access Journals (Sweden)

    Steven A Niederer

    2009-04-01

    Full Text Available We have developed a multi-scale biophysical electromechanics model of the rat left ventricle at room temperature. This model has been applied to investigate the relative roles of cellular scale length dependent regulators of tension generation on the transduction of work from the cell to whole organ pump function. Specifically, the role of the length dependent Ca(2+ sensitivity of tension (Ca(50, filament overlap tension dependence, velocity dependence of tension, and tension dependent binding of Ca(2+ to Troponin C on metrics of efficient transduction of work and stress and strain homogeneity were predicted by performing simulations in the absence of each of these feedback mechanisms. The length dependent Ca(50 and the filament overlap, which make up the Frank-Starling Law, were found to be the two dominant regulators of the efficient transduction of work. Analyzing the fiber velocity field in the absence of the Frank-Starling mechanisms showed that the decreased efficiency in the transduction of work in the absence of filament overlap effects was caused by increased post systolic shortening, whereas the decreased efficiency in the absence of length dependent Ca(50 was caused by an inversion in the regional distribution of strain.

  2. The role of the Frank-Starling law in the transduction of cellular work to whole organ pump function: a computational modeling analysis.

    Science.gov (United States)

    Niederer, Steven A; Smith, Nicolas P

    2009-04-01

    We have developed a multi-scale biophysical electromechanics model of the rat left ventricle at room temperature. This model has been applied to investigate the relative roles of cellular scale length dependent regulators of tension generation on the transduction of work from the cell to whole organ pump function. Specifically, the role of the length dependent Ca(2+) sensitivity of tension (Ca(50)), filament overlap tension dependence, velocity dependence of tension, and tension dependent binding of Ca(2+) to Troponin C on metrics of efficient transduction of work and stress and strain homogeneity were predicted by performing simulations in the absence of each of these feedback mechanisms. The length dependent Ca(50) and the filament overlap, which make up the Frank-Starling Law, were found to be the two dominant regulators of the efficient transduction of work. Analyzing the fiber velocity field in the absence of the Frank-Starling mechanisms showed that the decreased efficiency in the transduction of work in the absence of filament overlap effects was caused by increased post systolic shortening, whereas the decreased efficiency in the absence of length dependent Ca(50) was caused by an inversion in the regional distribution of strain.

  3. Mechanism of the Frank-Starling law--a simulation study with a novel cardiac muscle contraction model that includes titin and troponin I.

    Science.gov (United States)

    Schneider, Natalie S; Shimayoshi, Takao; Amano, Akira; Matsuda, Tetsuya

    2006-09-01

    A stretch-induced increase of active tension is one of the most important properties of the heart, known as the Frank-Starling law. Although a variation of myofilament Ca(2+) sensitivity with sarcomere length (SL) change was found to be involved, the underlying molecular mechanisms are not fully clarified. Some recent experimental studies indicate that a reduction of the lattice spacing between thin and thick filaments, through the increase of passive tension caused by the sarcomeric protein titin with an increase in SL within the physiological range, promotes formation of force-generating crossbridges (Xbs). However, the mechanism by which the Xb concentration determines the degree of cooperativity for a given SL has so far evaded experimental elucidation. In this simulation study, a novel, rather simple molecular-based cardiac contraction model, appropriate for integration into a ventricular cell model, was designed, being the first model to introduce experimental data on titin-based radial tension to account for the SL-dependent modulation of the interfilament lattice spacing and to include a conformational change of troponin I (TnI). Simulation results for the isometric twitch contraction time course, the length-tension and the force-[Ca(2+)] relationships are comparable to experimental data. A complete potential Frank-Starling mechanism was analyzed by this simulation study. The SL-dependent modulation of the myosin binding rate through titin's passive tension determines the Xb concentration which then alters the degree of positive cooperativity affecting the rate of the TnI conformation change and causing the Hill coefficient to be SL-dependent.

  4. Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.

    Science.gov (United States)

    Ait-Mou, Younss; Hsu, Karen; Farman, Gerrie P; Kumar, Mohit; Greaser, Marion L; Irving, Thomas C; de Tombe, Pieter P

    2016-02-23

    The Frank-Starling mechanism of the heart is due, in part, to modulation of myofilament Ca(2+) sensitivity by sarcomere length (SL) [length-dependent activation (LDA)]. The molecular mechanism(s) that underlie LDA are unknown. Recent evidence has implicated the giant protein titin in this cellular process, possibly by positioning the myosin head closer to actin. To clarify the role of titin strain in LDA, we isolated myocardium from either WT or homozygous mutant (HM) rats that express a giant splice isoform of titin, and subjected the muscles to stretch from 2.0 to 2.4 μm of SL. Upon stretch, HM compared with WT muscles displayed reduced passive force, twitch force, and myofilament LDA. Time-resolved small-angle X-ray diffraction measurements of WT twitching muscles during diastole revealed stretch-induced increases in the intensity of myosin (M2 and M6) and troponin (Tn3) reflections, as well as a reduction in cross-bridge radial spacing. Independent fluorescent probe analyses in relaxed permeabilized myocytes corroborated these findings. X-ray electron density reconstruction revealed increased mass/ordering in both thick and thin filaments. The SL-dependent changes in structure observed in WT myocardium were absent in HM myocardium. Overall, our results reveal a correlation between titin strain and the Frank-Starling mechanism. The molecular basis underlying this phenomenon appears not to involve interfilament spacing or movement of myosin toward actin but, rather, sarcomere stretch-induced simultaneous structural rearrangements within both thin and thick filaments that correlate with titin strain and myofilament LDA.

  5. The cross-bridge dynamics is determined by two length-independent kinetics: Implications on muscle economy and Frank-Starling Law.

    Science.gov (United States)

    Amiad Pavlov, Daria; Landesberg, Amir

    2016-01-01

    The cellular mechanisms underlying the Frank-Starling Law of the heart and the skeletal muscle force-length relationship are not clear. This study tested the effects of sarcomere length (SL) on the average force per cross-bridge and on the rate of cross-bridge cycling in intact rat cardiac trabeculae (n=9). SL was measured by laser diffraction and controlled with a fast servomotor to produce varying initial SLs. Tetanic contractions were induced by addition of cyclopiazonic acid, to maintain a constant activation. Stress decline and redevelopment in response to identical ramp shortenings, starting at various initial SLs, was analyzed. Both stress decline and redevelopment responses revealed two distinct kinetics: a fast and a slower phase. The duration of the rapid phases (4.2 ± 0.1 msec) was SL-independent. The second slower phase depicted a linear dependence of the rate of stress change on the instantaneous stress level. Identical slopes (70.5 ± 1.6 [1/s], p=0.33) were obtained during ramp shortening at all initial SLs, indicating that the force per cross-bridge and cross-bridge cycling kinetics are length-independent. A decrease in the slope at longer SLs was obtained during stress redevelopment, due to internal shortening. The first phase is attributed to rapid changes in the average force per cross-bridge. The second phase is ascribed to both cross-bridge cycling between its strong and weak conformations and to changes in the number of strong cross-bridges. Cross-bridge cycling kinetics and muscle economy are length-independent and the Frank-Starling Law cannot be attributed to changes in the force per cross-bridge or in the single cross-bridge cycling rates.

  6. Die "Judenwissenschaft" im nationalsozialistischen Dritten Reich. Überlegungen zur "Forschungsabteilung Judenfrage" in Walter Franks "Reichsinstitut für Geschichte des neuen Deutschlands" und zu den Untersuchungen Tübinger Professoren zur "Judenfrage"

    DEFF Research Database (Denmark)

    Lammers, Karl Christian; Raphaël, Freddy

    2001-01-01

    Undersøgelse af den såkaldte "Judenwissenschaft" under det nazistiske Reichsinstitut für Geschichte des neuen Deutschlands, der havde tre professorer fra universitetet i Tübingen som vigtigste repræsentanter. Article on the socalled "Judenwissenschaft" under Walter Franks Reichsinstitut für Gesch...

  7. An Analysis of Coordinated Observations from NOAA’s Ronald H. Brown Ship and G-IV Aircraft in a Landfalling Atmospheric River over the North Pacific during CalWater-2015

    Energy Technology Data Exchange (ETDEWEB)

    Neiman, Paul J. [Physical Sciences Division, NOAA/Earth System Research Laboratory, Boulder, Colorado; Gaggini, Natalie [Science and Technology Corporation, and NOAA/Earth System Research Laboratory, Boulder, Colorado; Fairall, Christopher W. [Physical Sciences Division, NOAA/Earth System Research Laboratory, Boulder, Colorado; Aikins, Joshua [Cooperative Institute for Research in the Environmental Sciences, and NOAA/Earth System Research Laboratory, Boulder, Colorado; Spackman, J. Ryan [Science and Technology Corporation, and NOAA/Earth System Research Laboratory, Boulder, Colorado; Leung, L. Ruby [Pacific Northwest National Laboratory, Richland, Washington; Fan, Jiwen [Pacific Northwest National Laboratory, Richland, Washington; Hardin, Joseph [Pacific Northwest National Laboratory, Richland, Washington; Nalli, Nicholas R. [I. M. Systems Group, NOAA/NESDIS/STAR, College Park, Maryland; White, Allen B. [Physical Sciences Division, NOAA/Earth System Research Laboratory, Boulder, Colorado

    2017-09-01

    Using a diverse suite of mobile observing platforms deployed on NOAA’s Ronald H. Brown (RHB) research vessel and G-IV research aircraft during the CalWater-2015 field campaign, this study describes the structure and evolution of a long-lived atmospheric river (AR) modulated by six frontal waves over the northeastern Pacific on 20-25 January 2015. Satellite observations and reanalysis diagnostics provided synoptic-scale context, illustrating the warm, moist southwesterly airstream within the quasi-stationary AR situated between an upper-level trough and ridge. The AR remained offshore of the U.S. West Coast but made landfall across British Columbia where heavy precipitation and high melting levels occurred, resulting in flooding. Forty-seven rawinsondes launched from the RHB provided a comprehensive thermodynamic and kinematic depiction of the AR, including an upward intrusion of strong water-vapor transport in the low-level moist southwesterly flow during the passage of frontal waves 2 through 6. A collocated 1290-MHz wind profiler showed an abrupt frontal transition from southwesterly to northerly flow below 1 km MSL coinciding with the tail-end of AR conditions. Shipborne radar and disdrometer observations in the AR uniquely captured key microphysical characteristics of shallow warm rain, convection, and deep mixed-phase precipitation. Continuous and novel observations of sea-surface fluxes documented persistent ocean-surface evaporation into the AR and sensible-heat transfer from the AR into the ocean. The G-IV aircraft coordinated with the RHB and flew directly over the ship. Dropsonde and radar spatial analyses complemented the temporal depictions of the AR from the RHB. The AR characteristics varied, depending on the location of the cross section through the frontal waves.

  8. Towards the creation of a US national heritage: documentation and survey for the understanding and safeguard of the architecture of Frank Lloyd Wright

    Directory of Open Access Journals (Sweden)

    Mariella La Mantia

    2015-01-01

    Full Text Available The phenomenon that led in recent decades to the safeguard and enhancement of significant historic buildings in the US territory starts from afar: at the beginning of the last century, in fact, the Federal State considered it appropriate to adopt a number of institutions for the protection of natural sites and architectural achievements. It dates back to 1935 the drafting, by the National Park Service, of the first list of buildings,monuments and districts of historical interest of the US. In December 1933 was instead founded the Historic American Buildings Survey (HABS, the federal institution which represented for a long time one of the main references in the study of US architecture, thanks to a massive intervention of photographic, graphic and historic documentation of architectural works spread throughout the nation. This paper aims to illustrate the historical and cultural path which has led to the development of this phenomenon of protection of American historic buildings, emphasizing the role of graphic and photographic documentation in the restorations of the main works of Frank Lloyd Wright.

  9. Evaluation of geophysical logs and slug tests, phase II, at AIW Frank/Mid-County Mustang Superfund Site, Chester County, Pennsylvania

    Science.gov (United States)

    Conger, R.W.; Goode, D.J.; Sloto, R.A.

    2000-01-01

    Between September 1997 and October 1998, nine monitor wells were drilled at the AIW Frank/Mid-County Mustang Superfund Site in Chester County, Pa., to determine the horizontal and vertical distribution of contaminated ground water migrating from known contaminant sources. The U.S. Geological Survey conducted borehole geophysical logging and borehole television surveys in these boreholes to identify water-producing zones so that appropriate intervals could be screened in each borehole. Caliper logs and borehole television surveys were used to locate fractures; inflections on fluid-temperature and fluid-resistivity logs were used to locate possible water-bearing fractures, and heatpulseflowmeter measurements verified these locations. The borehole television surveys indicated that locally, the rocks of the Conestoga Limestone and Ledger Dolomite that underlie the site strike generally from northeast-southwest to east-west and dip steeply to the southeast and south approximately 63? to 76?. Slug tests were conducted at six boreholes to estimate transmissivity. Transmissivity from slug tests ranged from 21 feet squared per day in borehole CH-5669 to greater than 12,000 feet squared per day in boreholes CH-5665 and CH-5667. After interpretation of geophysical logs, borehole television surveys, and driller's logs, all boreholes were screened such that water-level fluctuations could be monitored and discrete water samples collected from one or more water-producing zones in each borehole.

  10. Effects of crustacean cardioactive peptide on the hearts of two Orthopteran insects, and the demonstration of a Frank-Starling-like effect.

    Science.gov (United States)

    da Silva, Sara R; da Silva, Rosa; Lange, Angela B

    2011-04-01

    Like vertebrate cardiovascular systems, the dorsal vessel of the Orthopteran insects Baculum extradentatum and Locusta migratoria is under myogenic as well as neural control, through the action of neurotransmitters, neuromodulators and neurohormones. It was previously shown that the excitatory neuropeptide, crustacean cardioactive peptide (CCAP), triggers an increase in heart rate in B. extradentatum, and CCAP-like immunoreactivity is present in the innervation to the heart in many insects. In the present study, CCAP resulted in a dose-dependent increase in heart rate and hemolymph flow velocity, or cardiac output, in B. extradentatum. In contrast, CCAP led to a significant increase in stroke volume and cardiac output in L. migratoria without modifying heart rate or aortic contraction frequency. Hemolymph flow through the excurrent ostia of L. migratoria, small openings or valves on the posterior aorta and anterior heart, was inhibited with increasing concentrations of CCAP, with complete inhibition seen at 10(-7) M CCAP. In the locust, CCAP increases the volume of hemolymph in the dorsal vessel by the synchronous closing of the excurrent ostia, resulting in more forceful heart contractions and increased stroke volume and cardiac output, without modifying heart rate through a physiological mechanism analogous to the Frank-Starling mechanism in vertebrates. Therefore, crustacean cardioactive peptide alters the contractile properties of cardiac tissue in both B. extradentatum and L. migratoria, allowing for an increase in blood flow and circulation.

  11. It is played well under energy-saving roofs. Kindergarten 'Anne Frank' (Wolgast) as a pilot project for energy efficient retrofitting; Unter energiesparenden Daechern spielt es sich gut. Wolgaster Kindergarten 'Anne Frank' als Pilotprojekt fuer energieeffizientes Sanieren

    Energy Technology Data Exchange (ETDEWEB)

    Schwarz, Ragna

    2011-07-01

    For now forty years' in the Kindergarten 'Anne Frank' in Wolgast (Mecklenburg-Western Pomerania, Federal Republic of Germany) children are prepared for the school. The building (a typical GDR prefabricated building) was in an energetically unfavourable condition conceivably and did not correspond to the today's regulations by far. Owing to the programs 'KfW local government credit' and 'social investment' - both started in the year 2007 - a financial instrument for an energetic retrofitting of buildings has opened up. In the meantime, the building being retrofitted from the foundation right up to the roof is considered as a pilot project of energy-efficient refurbishment of an old building for Mecklenburg-Western Pomerania and throughout Germany.

  12. 心脏作功的生物数学关系质疑Frank-Starling 心脏作功定律%Questioning the frank-starling law of the heart in perspective of the bio-mathematical relation on the heart working

    Institute of Scientific and Technical Information of China (English)

    何川; 何培芳

    2011-01-01

    Objective The theory that the energy of cardiac contraction (cardiac work,or heart working) is a function of the length of the muscle fiber (the end-diastolic volume,EDV) is known as the Frank-Starling law of the heart,which is reputed as the law of the cardiac work,and has been esteemed as trustworthy.This paper tests the truthfulness of the law from a new perspective of bio-physics and bio-mathematical relationship on the heart working.We know that a force does not do work when there is no displacement in the direction of this force.At a stage of the EDV,the heart has not yet begun its contraction (the length of myocardial fibers and the EDV have not changed),there is no systolic force doing work at all,and there is no functional relationship between the cardiac work and the initial length of myocardial fibers (EDV).At a stage of the contraction,generally,the heart working (W) is represented by the ejection of a volume (V) of blood under a pressure (P).The W during each contraction is calculated by multiplying the V of blood ejected by the P:W=P×V.Because the V is equal to the EDV minus the ESV,a formula was derived as:W=P× (EDV- ESV).That formula has been accepted ever since unanimously and universally.Nevertheless,viewed from the bio-mathematical relationship among the parameters W,P,EDV and ESV in the formula,it can be seen that there is no such functional relation between the W and the EDV.Here,the authors of this paper affirm that the Frank-Starling law of the heart is a failure to express the objective condition of the heart working from the biomathematic angle of the cardiac work,and it is not a true law.%心脏收缩释放的能量(作功)是心肌纤堆长度的函数,或谓心脏作功是心室舒张末期容积(EDV)的函数,即著名的Frank-Starling心脏定律,被认为是心脏作功的规律的正确表达.众所用知,对于一个力,当在这个力的方向上没有位移时是不作功的.在心室舒张末期,心脏尚未开始收缩,

  13. Electronic publication of new animal names - An interview with Frank-T. Krell, Commissioner of the International Commission on Zoological Nomenclature and Chair of the ICZN ZooBank Committee

    Science.gov (United States)

    2012-01-01

    On the 4th September 2012 the International Commission on Zoological Nomenclature announced an amendment to the International Code of Zoological Nomenclature allowing for electronic publication of the scientific names of animals. In this interview Frank-T. Krell discusses the implications of this amendment for authors wishing to publish descriptions of newly identified animal species in online and open access journals, and for the future of taxonomic science. PMID:22978411

  14. Fatty acids are important for the Frank-Starling mechanism and Gregg effect but not for catecholamine response in isolated rat hearts.

    Science.gov (United States)

    Pagliaro, P; Chiribiri, A; Gattullo, D; Penna, C; Rastaldo, R; Recchia, F A

    2002-11-01

    In some pathophysiological conditions myocardial metabolism can switch from mainly long chain fatty acid (LCFA) oxidation to mainly glucose oxidation. Whether the predominant fatty acid or glucose oxidation affects cardiac performance has not been defined. In a buffer perfused isovolumetrically contracting rat heart, oxidation of endogenous pool LCFA was avoided by inhibiting carnitine-palmitoyl-transferase I (CPT-I) with oxfenicine (2 mM). In order to restore fatty acid oxidation, hexanoate (1 mM), which bypasses CPT-I inhibition, was added to the perfusate. Three groups of hearts were subjected to either an increase in left ventricular volume (VV, +25%) or an increase in coronary flow (CF, +50%), or inotropic stimulation with isoproterenol (10(-8) and 10(-6) m). The increase in VV (the Frank-Starling mechanism) increased rate-pressure product (RPP) by 21 +/- 2% under control conditions, but only by 6 +/- 2% during oxfenicine-induced CPT-I inhibition. The contractile response to changes in VV recovered after the addition of hexanoate. Similar results were obtained in hearts, in which an increase in CF was elicited (the Gregg phenomenon). Isoproterenol caused a similar increase in contractility regardless of the presence of oxfenicine or hexanoate. In all groups, a commensurate increase in oxygen consumption accompanied the increase in contractility. The fatty acid oxidation is necessary for an adequate contractile response of the isolated heart to increased pre-load or flow, whereas the inotropic response to adrenergic beta-receptor stimulation is insensitive to changes in substrate availability.

  15. Abnormal splicing in the N-terminal variable region of cardiac troponin T impairs systolic function of the heart with preserved Frank-Starling compensation.

    Science.gov (United States)

    Feng, Han-Zhong; Chen, Guozhen; Nan, Changlong; Huang, Xupei; Jin, Jian-Ping

    2014-09-01

    Abnormal splice-out of the exon 7-encoded segment in the N-terminal variable region of cardiac troponin T (cTnT-ΔE7) was found in turkeys and, together with the inclusion of embryonic exon (eTnT), in adult dogs with a correlation with dilated cardiomyopathy. Overexpression of these cTnT variants in transgenic mouse hearts significantly decreased cardiac function. To further investigate the functional effect of cTnT-ΔE7 or ΔE7+eTnT in vivo under systemic regulation, echocardiography was carried out in single and double-transgenic mice. No atrial enlargement, ventricular hypertrophy or dilation was detected in the hearts of 2-month-old cTnT-ΔE7 and ΔE7+eTnT mice in comparison to wild-type controls, indicating a compensated state. However, left ventricular fractional shortening and ejection fraction were decreased in ΔE7 and ΔE7+eTnT mice, and the response to isoproterenol was lower in ΔE7+eTnT mice. Left ventricular outflow tract velocity and gradient were decreased in the transgenic mouse hearts, indicating decreased systolic function. Ex vivo working heart function showed that high afterload or low preload resulted in more severe decreases in the systolic function and energetic efficiency of cTnT-ΔE7 and ΔE7+eTnT hearts. On the other hand, increases in preload demonstrated preserved Frank-Starling responses and minimized the loss of cardiac function and efficiency. The data demonstrate that the N-terminal variable region of cardiac TnT regulates systolic function of the heart.

  16. Ronald Dworkin on abortion and assisted suicide.

    Science.gov (United States)

    Kamm, F M

    2001-01-01

    In the first part of this article, I raise questions about Dworkin's theory of the intrinsic value of life and about the adequacy of his proposal to understand abortion in terms of different ways of valuing life. In the second part of the article, I consider his argument in "The Philosophers' Brief on Assisted Suicide", which claims that the distinction between killing and letting die is morally irrelevant, the distinction between intending and foreseeing death can be morally relevant but is not always so. I argue that the killing/letting die distinction can be relevant in the context of assisted suicide, but also show when it is not. Then I consider why the intention/foresight distinction can be morally irrelevant and conclude by presenting an alternative argument for physician-assisted suicide.

  17. El Guggenheim Museum de New York. Interpretación del papel de la estructura a través de la colaboración entre Frank Lloyd Wright y Jaroslav J. Polivka

    OpenAIRE

    2012-01-01

    Arquitectura y estructura han ido siempre íntimamente ligadas, pero con la aparición del acero y el hormigón surgieron nuevas necesidades formales o estéticas. El Estilo Internacional se inclinó por separar la retícula estructural de los cerramientos. En cambio, la Escuela de Chicago forjó las bases de una arquitectura optimizada y racional. Frank Lloyd Wright, entre estas dos situaciones, optó por seguir las pautas naturales de los materiales, de forma “orgánica”, recuperan...

  18. ¿Una superación de los límites de la representación? La reelaboración del debate en Frank Ankersmit y su recurso al testimonio

    Directory of Open Access Journals (Sweden)

    Esteban Lythgoe

    2010-11-01

    Full Text Available El presente artículo analiza el replanteo de Frank Ankersmit del debate en torno a los límites de la representación y su propuesta de recurrir al testimonio de los sobrevivientes del Holocausto. Se sostiene que su respuesta a la pregunta reelaborada resulta insatisfactoria tanto por inconsistencias internas como porque sus consecuencias son inapropiadas. Las limitaciones internas pondrán de manifiesto que el problema no reside en el tipo de respuesta dada sino en la reelaboración del debate. Por su parte, nuestro interés en las dificultades externas se debe a que no sólo afectan al filósofo tematizado sino a todos aquellos que privilegien los testimonios de los sobrevivientes por sobre las representaciones históricas.This paper analyses Frank Ankersmit's interpretation of the discussion on the limits of representation and his proposal to avoid it by using the testimony of the survivors of the Holocaust. It is sustained that his answer to this discussion if unsatisfactory due both to internal inconsistencies and its inappropriate consequences. Its internal limitations will show that the problem does not lie in the given answer but in the elaboration of the debate. On the other side, the reason of our interest in the external difficulties is that it does not only affect to Ankersmit's proposal but to every one that gives more importance to the survivers' testimonies than to the historical representations.

  19. La marge comme seuil de l’œuvre, vue d’ensemble sur cette forme de paratexte dans l’œuvre Shut Up’n Play Yer Guitar de Frank Zappa

    OpenAIRE

    Ganon, Nastasia

    2015-01-01

    Il s’agira dans cet article de comprendre les mécanismes extra-musicaux (que nous nommerons « marginaux ») à l’œuvre dans l’album Shut Up’n Play Yer Guitar de Frank Zappa. Afin de définir leur(s) rôle(s) et leur impact, non seulement dans l’œuvre mais aussi sur l’auditeur, nous effectuerons une étude philologique et génétique de l’objet en question (la pochette d’album). Après quoi il sera possible de redéfinir l’architecture de l’œuvre de Zappa, et de s’interroger sur la limite spatiale d’un...

  20. Josef Frank and the history of architecture: Gothic and the Renaissance, Leon Battista Alberti and Albrecht Dürer in the architectural discourse on Neues Bauen at the beginning of the 1930s

    Directory of Open Access Journals (Sweden)

    Caterina Cardemone

    2016-06-01

    Full Text Available The paper focuses on Josef Frank’s convinced use of historiographical arguments in his sharp critique of German modernist architecture. Frank’s attention to architectural history dates back to his education at the Technische Hochschule in Vienna, with Carl König, and the writing of a doctoral thesis on Leon Battista Alberti’s religious buildings in 1910. If a profound knowledge of Alberti’s writings informs Frank’s entire theoretical work, the point discussed here is the parallel between Neues Bauen and Gothic traced by Frank to exclude Neues Bauen from a true modernity, based, on the opposite, on a classical tradition of thought. An attempt is made to reconstruct Frank’s historiographical references and to insert his work in the broader historiographical context, thus highlighting a close link between architectural theory and critique on the one hand and contemporary historiographical constructions on the other.

  1. The Transplantation and Reinterpretation of the Mandate of Heaven in Frank Chin’ s Donald Duk%“天命观”在赵健秀《杜老鸭》中的移植与再阐释

    Institute of Scientific and Technical Information of China (English)

    李贵苍; 陈超君

    2015-01-01

    Frank Chin in his postmodern novel Donald Duk artistically transplants the Confucian concept of the mandate of heaven, and uses it as a pure ethical principle for his creation of Donald Duk, a Chinese A-merican cultural hero of revenge.In light of Said’ s traveling theory, this paper analyzes in what manner the Confucian concept of the mandate of heaven travels with the Chinese classics in the historical context of Ameri-can Orientalism, and how Chin reinterprets the mandate as the ethical code of private revenge so as to recon-struct the ideal cultural identity and image for Chinese Americans.%华裔作家赵健秀(Frank Chin)在其后现代小说《杜老鸭》(Donald Duk)中,艺术地移植了儒学的“天命观”,并以此为伦理基础塑造杜老鸭这个崇尚血性和复仇的华裔文化英雄形象。本文借鉴萨义德的旅行理论,分析儒家的“天命观”思想如何随中国经典“旅行”到美国,并在美国东方主义的历史语境下,如何成为赵健秀在小说中阐释为其反叛伦理的基础,并以此重构他心目中理想的华裔身份和形象。

  2. Depressed Frank-Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation ΔK210.

    Science.gov (United States)

    Inoue, Takahiro; Kobirumaki-Shimozawa, Fuyu; Kagemoto, Tatsuya; Fujii, Teruyuki; Terui, Takako; Kusakari, Yoichiro; Hongo, Kenichi; Morimoto, Sachio; Ohtsuki, Iwao; Hashimoto, Kazuhiro; Fukuda, Norio

    2013-10-01

    It has been reported that the Frank-Starling mechanism is coordinately regulated in cardiac muscle via thin filament "on-off" equilibrium and titin-based lattice spacing changes. In the present study, we tested the hypothesis that the deletion mutation ΔK210 in the cardiac troponin T gene shifts the equilibrium toward the "off" state and accordingly attenuate the sarcomere length (SL) dependence of active force production, via reduced cross-bridge formation. Confocal imaging in isolated hearts revealed that the cardiomyocytes were enlarged, especially in the longitudinal direction, in ΔK210 hearts, with striation patterns similar to those in wild type (WT) hearts, suggesting that the number of sarcomeres is increased in cardiomyocytes but the sarcomere length remains unaltered. For analysis of the SL dependence of active force, skinned muscle preparations were obtained from the left ventricle of WT and knock-in (ΔK210) mice. An increase in SL from 1.90 to 2.20μm shifted the mid-point (pCa50) of the force-pCa curve leftward by ~0.21pCa units in WT preparations. In ΔK210 muscles, Ca(2+) sensitivity was lower by ~0.37pCa units, and the SL-dependent shift of pCa50, i.e., ΔpCa50, was less pronounced (~0.11pCa units), with and without protein kinase A treatment. The rate of active force redevelopment was lower in ΔK210 preparations than in WT preparations, showing blunted thin filament cooperative activation. An increase in thin filament cooperative activation upon an increase in the fraction of strongly bound cross-bridges by MgADP increased ΔpCa50 to ~0.21pCa units. The depressed Frank-Starling mechanism in ΔK210 hearts is the result of a reduction in thin filament cooperative activation.

  3. Magnetic, specific heat and electrical transport properties of Frank-Kasper cage compounds RTM2Al20 [R  =  Eu, Gd and La; TM  =  V, Ti

    Science.gov (United States)

    Kumar, K. Ramesh; Nair, Harikrishnan S.; Christian, Reinke; Thamizhavel, A.; Strydom, André M.

    2016-11-01

    Single crystals of Frank-Kasper compounds RTM2Al20 (R  =  Eu, Gd and La; TM  =  V and Ti) were grown by self-flux method and their physical properties were investigated through magnetization (M), magnetic susceptibility (χ), specific heat (C P) and electrical resistivity (ρ) measurements. Powder x-ray diffraction studies and structural analysis showed that these compounds crystallize in the cubic crystal structure with the space group Fd\\bar{3}m . The magnetic susceptibility for the compounds EuTi2Al20 and GdTi2Al20 showed a sudden jump below the Néel temperature T N indicative of plausible double magnetic transition. Specific heat (C P) and electrical resistivity (ρ) measurements also confirm the first-order magnetic transition (FOMT) and possible double magnetic transitions. Temperature variation of heat capacity showed a sharp phase transition and huge C P value for the (Eu/Gd)Ti2Al20 compounds’ full width at half-maximum (FWHM) (text{P}}-γ T\\right)/{{T}3} versus T plot showed a maximum near 27 K for all the compounds indicating the presence of low frequency Einstein modes of vibrations. Resistivity measurements showed that all the samples behave as normal Fermi liquid type compounds and ρ (T) due to electron-phonon scattering follows Bloch-Grüneisen-Mott relation in the paramagnetic region.

  4. Master Builders: Move Over, Frank Lloyd Wright!

    Science.gov (United States)

    Carter, Beth W.

    1985-01-01

    Building projects with blocks provide opportunities to foster creative thinking skills. The connection between blocks and thinking how to implement the strategy are included, along with examples. (MNS)

  5. Polizei-Compliance / Frank Braun, Florian Albrecht

    Index Scriptorium Estoniae

    Braun, Frank

    2015-01-01

    Normide ja seaduste järgimisest politsei tegevuses ning vastavussüsteemi juurutamisest politseiorganisatsioonis tegevuse läbipaistvamaks muutmiseks, halduse optimeerimiseks ja kodanike usalduse suurendamiseks

  6. 2577-IJBCS-Article-Frank Ngoyi Tshite

    African Journals Online (AJOL)

    hp

    Une diminution sensible de la teneur en protéine a été observée ... childhood food using local materials in view to contributing to protein and energy ..... végétale et de la technologie employée. (Mouquet ... variables de matières grasses (huile.

  7. Polizei-Compliance / Frank Braun, Florian Albrecht

    Index Scriptorium Estoniae

    Braun, Frank

    2015-01-01

    Normide ja seaduste järgimisest politsei tegevuses ning vastavussüsteemi juurutamisest politseiorganisatsioonis tegevuse läbipaistvamaks muutmiseks, halduse optimeerimiseks ja kodanike usalduse suurendamiseks

  8. Er Frank rationel demokrat eller naiv fetichist?

    DEFF Research Database (Denmark)

    Rösing, Lilian Munk

    2014-01-01

    Artiklen er en diskussion af demokrati-begrebet i Rune Lykkebergs Alle har ret. Over for Lykkebregs demokrati-begreb sætter den Rancières og Zizeks forståelse af demokratiet som en åbning for det, den sociale orden ikke kan rumme. Det fører til en kritik af Lykkebergs anvendelse af begreberne om ...

  9. Child Protagonists: The "Anne Franks" of Today

    Science.gov (United States)

    Klein, Ana Maria

    2003-01-01

    The literary works surveyed here were written by authors who, as children, witnessed apartheid, holocaust, imprisonment, escape, genocide, ethnic cleansing, and other horrors that marked their lives. In each case, the selected texts are rendered as diaries or as first-person narratives describing disturbing situations which are resolved either…

  10. Who discovered the Frank-Starling mechanism?

    Science.gov (United States)

    Zimmer, Heinz-Gerd

    2002-10-01

    In 1866 at Carl Ludwig's Physiological Institute at Leipzig, Elias Cyon described the influence of diastolic filling of the isolated perfused frog heart on ejection volume. A study performed at the institute of the effect of filling pressure on contraction amplitude was published in 1869 by Joseph Coats, based on a recording made by Henry P. Bowditch.

  11. Magnetic, specific heat and electrical transport properties of Frank-Kasper cage compounds RTM2Al20 [R  =  Eu, Gd and La; TM  =  V, Ti].

    Science.gov (United States)

    Ramesh Kumar, K; Nair, Harikrishnan S; Christian, Reinke; Thamizhavel, A; Strydom, André M

    2016-11-02

    Single crystals of Frank-Kasper compounds RTM2Al20 (R  =  Eu, Gd and La; TM  =  V and Ti) were grown by self-flux method and their physical properties were investigated through magnetization (M), magnetic susceptibility (χ), specific heat (C P) and electrical resistivity (ρ) measurements. Powder x-ray diffraction studies and structural analysis showed that these compounds crystallize in the cubic crystal structure with the space group [Formula: see text]. The magnetic susceptibility for the compounds EuTi2Al20 and GdTi2Al20 showed a sudden jump below the Néel temperature T N indicative of plausible double magnetic transition. Specific heat (C P) and electrical resistivity (ρ) measurements also confirm the first-order magnetic transition (FOMT) and possible double magnetic transitions. Temperature variation of heat capacity showed a sharp phase transition and huge C P value for the (Eu/Gd)Ti2Al20 compounds' full width at half-maximum (FWHM) (<0.2 K) which is reminiscent of a first-order phase transition and a unique attribute among RTM2Al20 compounds. In contrast, linear variation of C P is observed in the ordered state for (Eu/Gd)V2Al20 compounds suggesting a λ-type transition. We observed clear anomaly between heating and cooling cycle in temperature-time relaxation curve for the compounds GdTi2Al20 (2.38 K) and EuTi2Al20 (3.2 K) which is indicating a thermal arrest due to the latent heat. The temperature variation of S mag for GdTi2Al20 saturates to a value [Formula: see text] while the other magnetic systems exhibited still lower entropy saturation values in the high temperature limit. [Formula: see text] versus T plot showed a maximum near 27 K for all the compounds indicating the presence of low frequency Einstein modes of vibrations. Resistivity measurements showed that all the samples behave as normal Fermi liquid type compounds and [Formula: see text] due to electron-phonon scattering follows Bloch-Grüneisen-Mott relation in

  12. Probability is Partial Belief-- Evaluation and Analysis on Frank Ramsey's Subjectivist Probability Theory%概率即部分信念——拉姆齐主观主义概率观探讨

    Institute of Scientific and Technical Information of China (English)

    季爱民

    2012-01-01

    Frank Ramsey is the first person to put forward the subjectivist probability theory. By refuting Keynes' logicl explanation of the probability idea,Ramsey formally expounded the subjectivist idea in 1926 that 'probability is partial belief'. Ramsey believed that partial belief could be shown in the act of betting and the value of probability could be measured by the betting quotient. And then, by arguing the Dutch Book Argument,the law of the logic of probability theory is rigorously established in subjectivism, and the reasonableness of the subjeetivist view of probability is based on subjective basis of scientific. In this way, it give us a clear justification for the axioms of the calculus and opens up a new perspective which has emerged in the study of probability. The probability depends on subjective evaluation which is established in the decision-makers perception of external events, and laid the foundation on the development of modern decision theory.%拉姆齐是主观主义概率观的最初提出者。通过对凯恩斯概率逻辑解释的辩驳,1926年拉姆齐首次正式阐释了“概率即部分信念”的主观主义概率观。部分信念可以通过打赌行为显示出来,概率数值的大小可以用赌商来测定。进而,通过荷兰赌定理的论证,概率论的逻辑规律在主观主义观点中被严格确立,这种观点的合理性具有了科学的主观基础。概率的主观解释为概率公理提供了明确的辩护,开辟了概率研究的新视角,概率依赖于建立在决策者认知上的对外部事件的主观评价,为现代决策论的发展奠定了基础。

  13. Ronald Reagan's "Star Wars" Address: Mythic Containment of Technical Reasoning.

    Science.gov (United States)

    Rushing, Janice Hocker

    1986-01-01

    Views Reagan's "Star Wars" address as part of the culturally evolving myth of the New Frontier. Discusses how the speech creates the illusion of both preserving and transcending science by (1) subordinating technical reasoning to prevent nuclear holocaust and (2) using technoscience to rescript history and remove temporal and spacial…

  14. The Rise and Fall of Japanology: Recollections of Ronald Dore

    Directory of Open Access Journals (Sweden)

    John Lie

    2015-03-01

    Full Text Available Ezra F. Vogel’s Japan as Number One augured the high tide of Japan and Japanology. Subtitled “Lessons for America,” the 1979 book preceded the property and share price bubble of the 1980s that seemed to make Japan the largest and most dynamic economy in the world. Vogel’s conspectus of Japanese society delineated a well-functioning, nearly ideal society: excellent schools, good labor relations, capable bureaucrats, and much more. Indeed, many American business people and policymakers heeded “lessons” from Japan, whether the idea of kaizen [improvement] or industrial policy. American students flocked to Japanese language classes; the future of Japan Studies appeared rosy indeed. Vogel’s book tickled Japanese national pride and went on to sell over 700,000 copies, making it the bestselling social science book of all time in Japan...

  15. Lääs vajab uut idapoliitikat / Ronald D. Asmus

    Index Scriptorium Estoniae

    Asmus, Ronald D., 1957-2011

    2007-01-01

    Autor, USA Saksa Marshalli Sihtasutuse Transatlantilise Keskuse direktor on seisukohal, et Venemaa on muutunud mitteliberaalseks, kasvavalt autoritaarseks riigiks. Tema sõnul tuleb koostööd Venemaaga võtmevaldkondades jätkata, kuid teistes valdkondades peab Moskvaga ka konkureerima

  16. Right face : understanding German political developments/ Ronald E. Draker.

    OpenAIRE

    1994-01-01

    Before unification in 1990, Germany experienced a rise in right-wing violence and political popularity. The trend has continued until the present. Many scholars attribute the phenomenon to the economic and social impact of unification and the wave of immigrants pouring into Germany. This is only partly true. Since the trend began before unification, then the real roots lie somewhere else. This thesis suggests that the rise in right-wing extremism is linked to the growing pressures of post-ind...

  17. Greetings from the new Editor-in-Chief, Ronald Stambaugh Greetings from the new Editor-in-Chief, Ronald Stambaugh

    Science.gov (United States)

    Stambaugh, Ronald

    2012-04-01

    I am very pleased to join the outstanding leadership team for the journal Nuclear Fusion as Scientific Editor. The journal's high position in the field of fusion energy research derives in no small measure from the efforts of the IAEA team in Vienna, the production and marketing of IOP Publishing, the Board of Editors led by its chairman Mitsuru Kikuchi, the Associate Editor for Inertial Confinement Max Tabak and the outgoing Scientific Editor, Paul Thomas. During Paul's five year tenure submissions have grown by over 40%. The usage of the electronic journal has grown year by year with about 300 000 full text downloads of Nuclear Fusion articles in 2011, an impressive figure due in part to the launch of the full 50 year archive. High quality has been maintained while times for peer review and publishing have been reduced and the journal achieved some of the highest impact factors ever (as high as 4.27). The journal has contributed greatly to building the international scientific basis for fusion. I was privileged to serve from 2003 to 2010 as chairman of the Coordinating Committee for the International Tokamak Physics Activity (ITPA) which published in Nuclear Fusion the first ITER Physics Basis (1999) and its later update (2007). The scientific basis that has been developed to date for fusion has led to the construction of major facilities to demonstrate the production of power-plant relevant levels of fusion reactions. We look forward to the journal continuing to play a key role in the international effort toward fusion energy as these exciting major facilities and the various approaches to fusion continue to be developed. It is clear that Nuclear Fusion maintains its position in the field because of the perceived high quality of the submissions, the refereeing and the editorial processes, and the availability and utility of the online journal. The creation of the Nuclear Fusion Prize, led by the Board of Editors chairman Mitsuru Kikuchi, for the most outstanding paper published in the journal each year has furthered the submission and recognition of papers of the highest quality. The accomplishments of the journal's team over the last five years will be a tough act to follow but I look forward to working with this competent and dedicated group to continue the journal's high standards and ensure that Nuclear Fusion remains the journal of choice for authors and readers alike.

  18. Vermilion Harbor, Ohio. Detailed Project Report on Section 111, Shore Erosion Study. Stage 3 Documentation

    Science.gov (United States)

    1982-09-01

    Jean Lee Helen Bell Arline P. Ford Anne R. Turner Frank J. Lee Martha H. Keith Ronald Guy Hetche Ruth E. Partington Nancy Rothlmn Mark Magnotto Thomas...trs. G. R. Thompson Ruth E. Peterka Herbert Woods Julius A. Moes George W. Grossman F. F. Peterka Jane Hetche IOf 4 dL DEPARTMENT OF THE ARMY BUFFALO

  19. Racist Quotes from Persons of Note, Part II.

    Science.gov (United States)

    Fikes, Robert, Jr.

    1988-01-01

    Offers racist quotes about Blacks, Jews, Hispanics, Asians, Italians, Poles, and others, from famous persons such as John Wayne, Woodrow Wilson, William F. Buckley, Richard Wagner, Jesse Helms, Sam Rayburn, Walter Lippman, Jack London, Paul Lynde, Theodore Roosevelt, Frank Sinatra, Errol Flynn, Ezra Pound, Richard M. Nixon, and Ronald Reagan. (BJV)

  20. National Science Resources Center Project for Improving Science Teaching in Elementary Schools. Appendix A. School Systems With Exemplary Elementary Science Programs. Appendix B. Elementary Science Network

    Science.gov (United States)

    1988-12-01

    Practice Caprio , Michael J., Little Creek Elementary School Capron, Dawn, Dev./Managing Editor Science Weekly, Inc., Level Pre-A Capua, James V., President...School Di Felice, Ronald, Ridley Senior High School Di Martino, Frank, DiBiasio, Mark, Irving A. Robbins Junior High School Dickert, Roger L., Principal

  1. AHA scientific statement: Summary of the scientific conference on dietary fatty acids and cardiovascular health

    NARCIS (Netherlands)

    Kris-Etherton, P.; Daniels, S.R.; Eckel, R.H.; Engler, M.; Howard, B.V.; Krauss, R.M.; Lichtenstein, A.H.; Sacks, F.; St. Jeor, S.; Stampfer, M.; Grundy, S.M.; Zock, P.L.

    2001-01-01

    Conference Planning and Writing Committee:Penny Kris-Etherton, PhD, Stephen R. Daniels, MD, PhD, Robert H. Eckel, MD, Marguerite Engler, PhD, RN, Barbara V. Howard, PhD, Ronald M. Krauss, MD, Alice H. Lichtenstein, DSc, Frank Sacks, MD, Sachiko St. Jeor, PhD, Meir Stampfer, MD, DrPH, For the America

  2. Early Childhood, High School, and College: Educational Challenges and MDRC's Research

    Science.gov (United States)

    MDRC, 2014

    2014-01-01

    MDRC hosted a recent colloquium to celebrate their 40th anniversary and the contributions of former Board Chair Robert Solow. This paper summarizes a panel presentation featuring Frank Levy, Richard J. Murnane, Cecilia E. Rouse, and Ronald F. Ferguson, who discussed current challenges in education and how MDRC's research can help address them.

  3. My father's life.

    OpenAIRE

    Porth, R

    1995-01-01

    Medicine has many unsung heroes, and among them are physicians who spend their careers providing medical care in remote areas. In this article, Ronald Porth remembers the life of his father, Dr. Frank Porth, who for more than 30 years provided medical care on native reserves and in rural parts of the Prairies.

  4. My father's life.

    Science.gov (United States)

    Porth, R

    1995-09-01

    Medicine has many unsung heroes, and among them are physicians who spend their careers providing medical care in remote areas. In this article, Ronald Porth remembers the life of his father, Dr. Frank Porth, who for more than 30 years provided medical care on native reserves and in rural parts of the Prairies.

  5. 从汤亭亭在《孙行者》中对赵健秀的戏仿看其和平主义思想%The Pacifism Presented by the Frank Chin's Parody of Maxine Hong Kingston in "Trip master Monkey"

    Institute of Scientific and Technical Information of China (English)

    余星

    2015-01-01

    汤亭亭和赵健秀是美国最具影响力的两位美国华裔作家,他们关于华裔美国文学的论争一直被认为是华裔美国文学史上具有转折性的一章。汤亭亭在小说《孙行者》中戏仿赵健秀,成功塑造了一位第五代华裔惠特曼·阿辛的形象,并在戏仿中表达了自己的观点和主张,特别是她爱好和平的思想。%Maxine Hong Kingston and Frank Chin are the most influential Chinese-American writers in America.Their debate about Chinese American literature has been considered a chapter with a turning point in American literary history of Chinese de-scent.Maxine Hong Kingston plays in the novel "Trip master Monkey"in imitation of Frank Chin and successfully creates a fifth-generation Chinese Whitman Asin image as well as expresses their views and ideas in a parody,especially for her peace-loving thought.

  6. Frank Welvaert : ravimite tootja mõju on probleem / Frank Welvaert ; interv. Toivo Tänavsuu

    Index Scriptorium Estoniae

    Welvaert, Frank

    2004-01-01

    Tervishoiufirma Johnson & Johnson direktor vastab küsimustele, mis on seotud Eesti meditsiinitöötajatele juhtimiskursuste korraldamisega. Eesti tervishoiusüsteemi kohta arvab ta, et tuleb haiglate arvu vähendada. Lisa: Kulutusi võiks suurendada

  7. Frank Welvaert : ravimite tootja mõju on probleem / Frank Welvaert ; interv. Toivo Tänavsuu

    Index Scriptorium Estoniae

    Welvaert, Frank

    2004-01-01

    Tervishoiufirma Johnson & Johnson direktor vastab küsimustele, mis on seotud Eesti meditsiinitöötajatele juhtimiskursuste korraldamisega. Eesti tervishoiusüsteemi kohta arvab ta, et tuleb haiglate arvu vähendada. Lisa: Kulutusi võiks suurendada

  8. 建构手段与建构审美--论弗兰克·盖里作品中的建构精神%The Tectonic Method and the Tectonic Aesthetic--About the Tectonic Spirit in Frank Owen Gehry‘s Work

    Institute of Scientific and Technical Information of China (English)

    赵晶; 曹磊

    2014-01-01

    建构是当前国内建筑设计理论与实践领域最为热烈的论题之一,本文从“建构”理论的基本概念及发展谈起,通过分析建筑大师弗兰克·盖里建筑作品中的建构精神及其建构设计手法在实际作品中的运用,深化我们对建构理论的认识,挖掘建构的内涵与作用,使建构的研究更具有社会现实与指意性。%Tectonics is one of the most fashionable topics of architecture design’s theory and practice field in current China. This paper discusses the issue from the basic concept and the development of tectonics. By analyzing tectonic spirit and its tectonic design method of the architect Frank Owen Gehry‘s actual work, it can deepen our understanding of tectonic theory and excavate the connotation and function of the tectonics, which makes the research of tectonics has more social reality significance and directivity meaning.

  9. Suur Norra naftafirma Statoil viskleb korruptsioonikeerises / Frank Skaufel

    Index Scriptorium Estoniae

    Skaufel, Frank

    2003-01-01

    Skandaalist, mis puhkes, kui ilmnes, et Statoil kasutas Aserbaidžaanis kontakti saavutamiseks ametivõimudega ja vajaliku informatsiooni saamiseks KGB agente. Firmale esitatud korruptsioonisüüdistustest

  10. A la muerte de un gran hombre. Frank Lloyd Wright

    Directory of Open Access Journals (Sweden)

    Neutra, Richard J.

    1959-12-01

    Full Text Available Si contemplamos las amarillas páginas de la Historia —tanto la antigua, que no hemos podido comprobar, como la moderna, que hemos verificado por medio de documentos—, encontraremos noticias equívocas e interpretaciones contradictorias. Incluso en nuestros días existen críticas opuestas sobre personajes tan objetivamente identificados como Julio César, Napoleón o Matías Grunewald. Y es que las preferencias de cada siglo ejercen decisiva influencia hasta en la historiografía de aspecto más científico.

  11. Scratching the First Teflon Presidency: Frank Kent vs. Franklin Roosevelt.

    Science.gov (United States)

    Olasky, Marvin N.

    While the typical pantheon of journalism history heroes is made up almost entirely of individuals who campaigned for more governmental regulation and increased social liberalism, there is also an opposing tradition in American journalism, one based on the premise that governmental cures are in most cases worse than the diseases they are designed…

  12. Adamkus shares frank words with Schroeder / Seputyte Milda

    Index Scriptorium Estoniae

    Milda, Seputyte

    2005-01-01

    Leedu president Valdas Adamkus kohtus Saksamaa kantsleri Gerhard Schröderiga ning avaldas pahameelt rajatava Vene-Saksa gaasijuhtme üle. Balti riigid ja Poola on seisukohal, et ka nemad peaksid olema kaasatud läbirääkimistesse Vene-Saksa gaasijuhtme rajamise suhtes

  13. Frank Talk about Hacker Attacks, Emergency Notification, and Online Piracy

    Science.gov (United States)

    Fischman, Josh; Carlson, Scott; Young, Jeffrey R.

    2008-01-01

    Technology decisions should not be made solely in some geeky corner of the campus, but should be central to strategic planning and involve top academic leaders. Campus-technology leaders traded tales from the trenches and plenty of advice during the two-day Technology Forum, held in Tampa, Florida in February 2008. Ohio University responded to a…

  14. On the extensions of the Frank-Worfe theorem

    NARCIS (Netherlands)

    Z-Q. Luo; S. Zhang (Shuzhong)

    1997-01-01

    textabstractIn this paper we consider optimization problems defined by a quadratic objective function and a finite number of quadratic inequality constraints. Given that the objective function is bounded over the feasible set, we present a comprehensive study of the conditions under which the opt

  15. SIBSIM - quantitative phenotype simulation in extended pedigreesFranke

    Directory of Open Access Journals (Sweden)

    Franke, Daniel

    2006-02-01

    Full Text Available A tool (SIBSIM is described for quantitative phenotype simulation in extended pedigrees. Download and installation information are given and the advantages and limitations of the tool are described. The input format is based on XML and the different sections of an input file are explained. A short explanation of the algorithm is given. Links to the download site, the user manual, and related literature as well as a detailed example are included.Availability: The software is available at: http://www.imbs.uni-luebeck.de/pub/sibsim

  16. Frank hematuria as the presentation feature of acute leukemia

    Directory of Open Access Journals (Sweden)

    Suriya Owais

    2010-01-01

    Full Text Available Muco-cutaneous bleeding is a common presenting feature of acute leukemias. Mucosal bleeding usually manifests as gum bleeding and/or epistaxis but may occur in any mucosal surface of the body. Hematuria as an isolated or main presenting feature of acute leukemia is rare. We describe two cases of acute leukemia, a 19 year old male with acute lymphoblastic leukemia and a 52 year old male with acute myeloid leukemia, both presenting with gross hematuria. There was no demonstrable leukemic infiltration of the urinary tract on imaging studies. Hematuria in these patients was likely to be due to occult leukemic infiltration of the urinary system, aggravated by thrombocytopenia, as it subsided after starting chemotherapy. Our cases highlight that hematuria should be remembered as a rare presenting feature of acute leukemia.

  17. Adamkus shares frank words with Schroeder / Seputyte Milda

    Index Scriptorium Estoniae

    Milda, Seputyte

    2005-01-01

    Leedu president Valdas Adamkus kohtus Saksamaa kantsleri Gerhard Schröderiga ning avaldas pahameelt rajatava Vene-Saksa gaasijuhtme üle. Balti riigid ja Poola on seisukohal, et ka nemad peaksid olema kaasatud läbirääkimistesse Vene-Saksa gaasijuhtme rajamise suhtes

  18. Titin Determines the Frank-Starling Relation in Early Diastole

    OpenAIRE

    Helmes, Michiel; Lim, Chee Chew; Liao, Ronglih; Bharti, Ajit; Cui, Lei; Sawyer, Douglas B.

    2003-01-01

    Titin, a giant protein spanning half the sarcomere, is responsible for passive and restoring forces in cardiac myofilaments during sarcomere elongation and compression, respectively. In addition, titin has been implicated in the length-dependent activation that occurs in the stretched sarcomere, during the transition from diastole to systole. The purpose of this study was to investigate the role of titin in the length-dependent deactivation that occurs during early diastole, when the myocyte ...

  19. Calcium, cross-bridges, and the Frank-Starling relationship.

    Science.gov (United States)

    Fuchs, F; Smith, S H

    2001-02-01

    The steep relationship between active force and length in cardiac muscle is based on a length dependence of myofilament Ca(2+) sensitivity. However, it is not muscle length but the lateral spacing between actin and myosin filaments that sets the level of Ca(2+) sensitivity, mainly through modulation of myosin-mediated activation of the thin filament.

  20. Titin determines the Frank-Starling relation in early diastole.

    Science.gov (United States)

    Helmes, Michiel; Lim, Chee Chew; Liao, Ronglih; Bharti, Ajit; Cui, Lei; Sawyer, Douglas B

    2003-02-01

    Titin, a giant protein spanning half the sarcomere, is responsible for passive and restoring forces in cardiac myofilaments during sarcomere elongation and compression, respectively. In addition, titin has been implicated in the length-dependent activation that occurs in the stretched sarcomere, during the transition from diastole to systole. The purpose of this study was to investigate the role of titin in the length-dependent deactivation that occurs during early diastole, when the myocyte is shortened below slack length. We developed a novel in vitro assay to assess myocyte restoring force (RF) by measuring the velocity of recoil in Triton-permeabilized, unloaded rat cardiomyocytes after rigor-induced sarcomere length (SL) contractions. We compared rigor-induced SL shortening to that following calcium-induced (pCa) contractions. The RF-SL relationship was linearly correlated, and the SL-pCa curve displayed a characteristic sigmoidal curve. The role of titin was defined by treating myocytes with a low concentration of trypsin, which we show selectively degrades titin using mass spectroscopic analysis. Trypsin treatment reduced myocyte RF as shown by a decrease in the slope of the RF-SL relationship, and this was accompanied by a downward and leftward shift of the SL-pCa curve, indicative of sensitization of the myofilaments to calcium. In addition, trypsin digestion did not alter the relationship between SL and interfilament spacing (assessed by cell width) after calcium activation. These data suggest that as the sarcomere shortens below slack length, titin-based restoring forces act to desensitize the myofilaments. Furthermore, in contrast to length-dependent activation at long SLs, length-dependent deactivation does not depend on interfilament spacing. This study demonstrates for the first time the importance of titin-based restoring force in length-dependent deactivation during the early phase of diastole.

  1. 78 FR 62662 - Ronald F. Lambert, D.D.S.; Decision and Order

    Science.gov (United States)

    2013-10-22

    ... would have had an enormous potential for injury to community.'' Id. Second, the Government argues that... representative of a manufacturer, distributor or pharmacy. 2. Respondent shall maintain a log of all controlled...

  2. 77 FR 27214 - Applications for New Awards; Ronald E. McNair Postbaccalaureate Achievement Program

    Science.gov (United States)

    2012-05-09

    ... preparation for doctoral study. The President has set a clear goal for our education system: By 2020, the... overarching reform strategies for postsecondary completion and graduate school enrollment, the Department is... you submit your application in a timely manner to the Grants.gov system. You can also find...

  3. Ronald Regan Boyhood Home National Historic Site Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  4. 75 FR 78745 - Ronald Lynch, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-12-16

    ... ] following day he received a telephone call from ``Jasmine at Modern Lifestyles,'' who asked ``what type of..., acupuncture and eating ``certain anti-inflammatory foods.'' Id. at 210, 214-15. He also maintained that he... prescribing or dispensing of a dangerous drug ``on the Internet for delivery to any person in this state...

  5. 77 FR 19076 - High Density Traffic Airports; Notice of Determination Regarding Low Demand Periods at Ronald...

    Science.gov (United States)

    2012-03-30

    ...\\ 33 FR 17896 (Dec. 3, 1968). In 1985, the FAA issued part 93 subpart S (the ``Buy/Sell Rule'').\\2\\ As... the 0600 hour is not a low demand period.\\3\\ \\2\\ 50 FR 52195 (Dec. 20, 1985). \\3\\ 76 FR 58393 (Sept... Federal Aviation Administration 14 CFR Part 93 High Density Traffic Airports; Notice of...

  6. GIS Facility and Services at the Ronald Greeley Center for Planetary Studies

    Science.gov (United States)

    Nelson, D. M.; Williams, D. A.

    2017-06-01

    At the RGCPS, we established a Geographic Information Systems (GIS) computer laboratory, where we instruct researchers how to use GIS and image processing software. Seminars demonstrate viewing, integrating, and digitally mapping planetary data.

  7. Vene kinopravdast sai prantsuse cinema-verite / Ronald Bergan ; tõlk. Ene Jürna

    Index Scriptorium Estoniae

    Bergan, Ronald

    2004-01-01

    FIPRESCI asepresident meenutab 18. veebruaril 2004.a. surnud prantsuse dokumentalistika suurkuju Jean Rouchi (sünd. 31.05.1917). Lisatud Jaan Ruusi kommentaar Rouchi sidemetest Eesti kineastide Mark Soosaare ja Vladimir Karassev-Orgussaarega

  8. Enough of Ronald and Mickey: Focusing on Learning in Outdoor Education

    Science.gov (United States)

    Beames, Simon; Brown, Mike

    2014-01-01

    Fifteen years ago Loynes expressed concern that market-place values were detrimentally impacting on the provision of outdoor education experiences. As tertiary educators with an interest in the impact of globalization on outdoor education, we have sought to extend Loynes' use of McDonaldization by drawing on Bryman's conceptual framework…

  9. Znovuzrození přírodní krásy: Ronald W. Hepburn

    OpenAIRE

    Dadejík , Ondřej

    2007-01-01

    The article considers the changing status of natural beauty in the twentieth century. This situation is presented with reference to extreme changes of interest connected with this field of value. The article begins by exploring some current theoretical presuppositions concerning this field (primarily the problem of making a distinction between artistic and natural aesthetic value considered within one aesthetic field). The focus of the following sections is on a pioneering text, which ended a...

  10. From Adam Smith to Ronald Reagan: Public Libraries as a Public Good.

    Science.gov (United States)

    Braverman, Miriam

    1982-01-01

    Contrasts the arguments of economists who measure the value of library services to society by business standards with the criteria of "the public good" which predominated during the development of public libraries and argues that libraries must continue to serve the whole community. Twenty references are cited. (RAA)

  11. Venemaa tahab režiimi vahetust Gruusias / Richard C. Holbrooke, Ronald D. Asmus

    Index Scriptorium Estoniae

    Holbrooke, Richard, 1941-2010

    2008-01-01

    Ilmunud ka: Den za Dnjom 15. aug. lk. 17. Venemaa eesmärk sõjas Gruusiaga on Gruusia režiimivahetus ning president Mikheil Saakashvili asendamine Kremli mõjudele avatuma presidendiga, leiavad autorid

  12. Report of Investigation: Ronald F. Lewis, Major General, U.S. Army

    Science.gov (United States)

    2016-10-04

    us that she thought it was “very odd ” that MG Lewis asked for his GTCC and that she “felt like something wrong was about to happen, but I wasn’t in a...saw that it was him, and I said, you know, “Sir, I’m going to check you out [of the hotel in the morning].” Like I felt like it was very odd that...attractive women approach and sit with patrons, because women order a drink (consumption [listed in the price list]) every 20 minutes. Drinks

  13. Competing With Ronald McDonald, Cap'n Crunch and the Pepsi Generation.

    Science.gov (United States)

    Kamholtz, J. Dennis; Wood, Bill

    1982-01-01

    A new approach to elementary health education involves the use of a series of health-related games. The games address a variety of issues including nutrition, substance abuse, and dental health education. The story "Floss is the Boss" is used as an example. (JN)

  14. Pisike mikrobuss toob kinnisvarateenuse inimestele lähemale / Ronald Nermann ; interv. Aive Antsov

    Index Scriptorium Estoniae

    Nermann, Ronald

    2006-01-01

    Haabersti Maja nõukogu esimees tutvustab kinnisvarabussi, ettevõtte ainulaadset ratastel kontorit, mida võib kohata nii laatadel kui nende klientide juures, kellel on keeruline minna tavakontorisse

  15. Venemaa tahab režiimi vahetust Gruusias / Richard C. Holbrooke, Ronald D. Asmus

    Index Scriptorium Estoniae

    Holbrooke, Richard, 1941-2010

    2008-01-01

    Ilmunud ka: Den za Dnjom 15. aug. lk. 17. Venemaa eesmärk sõjas Gruusiaga on Gruusia režiimivahetus ning president Mikheil Saakashvili asendamine Kremli mõjudele avatuma presidendiga, leiavad autorid

  16. Ronald Reagan Boyhood Home National Historic Site Tract and Boundary Data

    Data.gov (United States)

    National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...

  17. Vene kinopravdast sai prantsuse cinema-verite / Ronald Bergan ; tõlk. Ene Jürna

    Index Scriptorium Estoniae

    Bergan, Ronald

    2004-01-01

    FIPRESCI asepresident meenutab 18. veebruaril 2004.a. surnud prantsuse dokumentalistika suurkuju Jean Rouchi (sünd. 31.05.1917). Lisatud Jaan Ruusi kommentaar Rouchi sidemetest Eesti kineastide Mark Soosaare ja Vladimir Karassev-Orgussaarega

  18. U.S. Navy Regional Climatic Study of the Greenland-Iceland-United Kingdom Gap and Associated Waters

    Science.gov (United States)

    1992-02-01

    Associated Waters 6. AUTHOR(S) William A. Brower, Jr., William 0. Brown, Ronald G. Baldwin, and Phala L. Franks 7. PERFORMING ORGANIZATION NAME(S) AND...meteorologists of the NCDC’s Global Climate Laboratory (GCL): William A. Brower, Jr., for serving as project leader and chief climatic analyst; William 0. Brown...ITOTI REAN NO. OF DAYS 4ITR (LI EANS I EATAEREIPERCENTIPP IP.I ALTI I I𔄂𔃻 TEMP IDEG F, I PRECIPITATION i OBSTR TO VISION I I I I ILST1 I.4.1 I

  19. Ajaloo representatsioon ja kogemus : intervjuu Frank Ankersmitiga / Frank Ankersmit ; intervjueerinud Marek Tamm ; ingliskeelsest käsikirjast tõlkinud Märt Väljataga

    Index Scriptorium Estoniae

    Ankersmit, Frank, 1945-

    2015-01-01

    Ajaloo uurimisest ja ajalookirjutusest. Historismist. Leibnizi tähtsusest ajaloofilosoofiale. Poliitilisest filosoofiast. Ajaloo kogemusest ja mineviku mõistest. Ajaloofilosoofiast ja ajalooteooriast

  20. Ajaloo representatsioon ja kogemus : intervjuu Frank Ankersmitiga / Frank Ankersmit ; intervjueerinud Marek Tamm ; ingliskeelsest käsikirjast tõlkinud Märt Väljataga

    Index Scriptorium Estoniae

    Ankersmit, Frank, 1945-

    2015-01-01

    Ajaloo uurimisest ja ajalookirjutusest. Historismist. Leibnizi tähtsusest ajaloofilosoofiale. Poliitilisest filosoofiast. Ajaloo kogemusest ja mineviku mõistest. Ajaloofilosoofiast ja ajalooteooriast

  1. Joint Aircraft Survivability Program Final Test Report for the Acoustic Fire Suppression Project JASP-TR-14-05

    Science.gov (United States)

    2016-09-01

    Fluid mechanics. In: Kreith F. editor. Mechanical engineering handbook. Boca Raton (FL): CRC Press; 1999. 10. Kuo KK, Acharya R. Fundamentals of...the Acoustical Society of America. 2013;133(4):2004–2013. 57. Karlsson B, Quintiere J. Enclosure fire dynamics. Boca Raton (FL): CRC Press; 2000

  2. Ronald McDonald dit: "Tout le monde connait: 'Deuxsteakshachessaucespecialesaladefromageoignons dansuntriplepainrondrecouvertdegrainsdesesames'" (Ronald McDonald Says: "Everyone Knows: 'Two-All-Beef-Patties-Special-Sauce-Lettuce-Cheese-Pickles- Onions-on-a-Sesame-Seed Bun'").

    Science.gov (United States)

    Headrick, Robert J., Jr.

    This booklet is intended for classroom use in first-year high school French to acquaint students with the McDonald's fast food restaurants in Paris. The specific objectives are for the student to: (1) discuss the similarities and differences between the American and Parisian McDonald's, (2) set up a miniature McDonald's in the classroom, (3) order…

  3. Ronald McDonald pregunta: "Puedes decir: 'dostortosdepurocarnederessalsaespeciallechugagueso- pepinillosycebollasenunpanconsemillasdeajonjoli'?" (Ronald McDonald Asks: "Can You Say: 'Two-All-Beef-Patties-Special-Sauce-Lettuce-Cheese-Pickles-Onions-On- A-Sesame-Seed-Bun'?" Activities in Spanish).

    Science.gov (United States)

    Headrick, Robert J., Jr.

    This booklet is intended for classroom use in first-year high school Spanish to acquaint students with the McDonald's fast food restaurants in Costa Rica. The specific objectives are for the student to: (1) discuss the similarities and differences between the American and Costa Rican McDonald's, (2) set up a miniature McDonald's in the classroom,…

  4. How do classical particle-field systems become unstable? - The last physics problem that Ronald Davidson studied

    Science.gov (United States)

    Qin, Hong

    2016-10-01

    Many of the classical particle-field systems in (neutral and nonneutral) plasma physics and accelerator physics become unstable when the system parameters vary. How do these instabilities happen? It turns out, very interestingly, that all conservative systems become unstable by the same mechanism, i.e, the resonance between a positive- and a negative-action modes. And this is the only route that a stable system can become unstable. In this talk, I will use several examples in plasma physics and accelerator physics with finite and infinite degrees of freedom to illustrate the basic physical picture and the rigorous theoretical structure of the process. The features at the transition between stable and unstable regions in the parameter space are the fundamental characteristics of the underlying real Hamiltonian system and complex G-Hamiltonian system. The resonance between a positive- and a negative-action modes at the transition is the Krein collision well-known to mathematicians. Research supported by the U.S. Department of Energy (DE-AC02-09CH11466).

  5. Can malt whisky be discriminated from blended whisky? The proof. A modification of Sir Ronald Fisher's hypothetical tea tasting experiment.

    Science.gov (United States)

    Chadwick, S J; Dudley, H A

    A modified version of Fisher's tea tasting experiment was performed to test the confident assertions of some members of an academic surgical unit that they could easily distinguish malt from blend whisky. Eight male volunteers from the unit, divided into regular and inexperienced whisky drinkers, were blindfolded and given a glass of each of six whiskies. The whiskies included three malts and three blends, and each subject tasted each whisky six times. They were asked whether the whisky was malt or blended, whether they could identify the distillery, and whether they liked it (ranked on a nine-point scale). The four regular whisky drinkers identified the whiskies as malts 57 times, as blends 84 times, and did not know three times; the inexperienced drinkers identified them as malts 64 times, as blends 79 times, and did not know on one occasion. The regular drinkers correctly identified the malts 36 times and the blends 48 times, and the inexperienced drinkers correctly identified malts 30 times and blends 40 times. Statistical analysis of the data suggested that within the unit malt whisky could not be distinguished from blended whisky and that experience did not alter powers of discrimination. A surgeon with no discriminatory prowess at all could be expected to achieve complete discrimination of malt from blend whisky once in 2 occasions. These results suggest that, although "uisgebeatha" has unique properties, the inexpert drinker should choose his whisky to suit his taste and pocket and not his self image.

  6. 77 FR 60119 - Proposed Consent Agreements: DesignerWare, LLC, Timothy Kelly and Ronald P. Koller, Aspen Way...

    Science.gov (United States)

    2012-10-02

    ... not fully clothed, and couples engaged in intimate activities. The collection and disclosure of such... content through the computer's webcam or microphone. The definition of ``geophysical location tracking...

  7. Presidents as Symbols: An Investigation of John F. Kennedy's, Lyndon B. Johnson's, and Ronald Reagan's Use of Presidential Allusions.

    Science.gov (United States)

    Smith-Howell, Deborah

    This paper presents an examination of United States presidents' names as symbols. In developing the analysis, the paper: (1) reviews multiple perspectives which suggest that allusions to past presidents (such as Thomas Jefferson, Abraham Lincoln, or Franklin Roosevelt) are significant political symbols; (2) discusses how allusions to past…

  8. On becomine a psychiatrist: discussion of "Empathy and intuition in becoming a psychiatrist," by Ronald J. Blank.

    Science.gov (United States)

    Langs, R

    1976-01-01

    Using the data from Blank's (1976) description of his clinical efforts with his first patient, selected tissues on becoming a psychiatrist and psychotherapist are explored. Considered among the motives for entering this profession are opportunities for the therapist to projectively identify into his patients, and to introjectively identify with and contain his patients' psychopathology. The relationship between empathy and intuition on the one hand, and projection and projective identification on the other, is also studied, as is the need for the application of the validating process in confirming all so-called empathic and intuitive responses on the part of the therapist. Counter-transference influences on the experience and use of empathy and intuition are also investigated. The development of therapeutic misalliances and framework "cures," the distinction between transference and nontransference, the constructive elements contained in essentially countertransference-based interventions, the mastery of countertransference difficulties, and the choice of insight-oriented versus noninsightful therapeutic modalities are discussed.

  9. R.M.S Titanic 2004 Expedition on the NOAA Ship Ronald H. Brown between 20040527 and 20040612

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In collaboration with the National Oceanic and Atmospheric Administration?s (NOAA) Office of Ocean Exploration (OE), the Institute for Exploration (IFE) requests...

  10. Great Communicating: Learning from Ronald Reagan’s Public Appeals to Address the Obesity Epidemic in America

    Science.gov (United States)

    2007-11-02

    death 2004, Matt Foreman, of the National Gay and Lesbian Task Force said, "I wouldn’t feel so angry if the Reagan administration’s failing was due to...Notwithstanding the existence of the gay Republican group, the Log Cabin Republicans, homosexuals tend then, as now, to politically affiliate themselves with the...for espousing an anti- gay stance, part of which may be attributed to the lasting effects of Reagan’s estrangement from homosexuals . Reagan could have

  11. The Extraterritorial Jurisdiction of the American Securities Law:The End or the Revival?-Morrison v.National Australia Bank and the Dodd-Frank Act%美国证券法域外管辖权:终结还是复活?*--评美国联邦最高法院Morrison案及《多德-弗兰克法》第929P(b)条

    Institute of Scientific and Technical Information of China (English)

    杜涛

    2012-01-01

    Before the case of Morrison v.National Australia Bank in 2010, the US courts had forty-year judicial practice in the foreign-related antifraud secur-ities litigation, which established a case law system on the basis of effect test and act test in the field of extraterritorial jurisdiction and extraterritorial application of law.However, the Federal Supreme Court criticized the above judicial practice in Morrison, which is its first trial concerning the foreign-related securities litigation. In addition, the Court also emphasized that the presumption against extraterritoriali-ty, a longstanding principle of interpretation, should play a great role in the extra-territorial application of the federal securities law.As to the reach of the Section 10(b) of the Securities and Exchange Act of 1934, the Court stated a new clear rule—the transaction test.It is said that the Morrison is a big change in the history of the securities case law.However, within one day after the publication of the Mor-rison ruling, the House completed the Dodd-Frank Wall Street Reform and Consumer Protection Act, which raised a hot discussion among the academic and the practi-tioners.This article compares the US judicial practice of extraterritorial jurisdiction and extraterritorial application of law in the foreign-related securities litigation be-fore and after the Morrison, and then discusses the legal problems left by the Court, as wel as the influence of the Morrison.%美国法院在涉外证券欺诈案件的域外管辖权问题上经过四十多年的发展,建立起一套以“效果”和“行为”为标准的判例体系。然而,2010年,美国联邦最高法院对涉外证券案件(莫里森诉澳大利亚国民银行案)的首度介入却完全推翻了此一先例。在该案中,美国联邦最高法院强调了“反域外适用推定”这一解释规则对联邦证券法域外适用的重要性,并针对1934年《证券交易法》第10(b)条之域外适用

  12. A Fully Wheelchair Accessible Telescope for the Frank N. Bash Visitors Center

    Science.gov (United States)

    Cianciolo, F.; Wren, W.; Jones, M.; Dubberly, M.

    2008-06-01

    We present the design and description of a telescope that is fully wheelchair accessible. It is to be installed at the the McDonald Observatory Visitor Center and will service the needs of the general public at star parties and other night-time observing functions.

  13. Karm võitlus Euroopa Eldorado eest - kellele kuulub Rumeenia kuld? / Frank Sprenk-Dorn

    Index Scriptorium Estoniae

    Sprenk-Dorn, Frank

    2008-01-01

    Kanada päritolu kompanii Gabriel Resources Ltd soovib alustada kulla kaevandamist Rumeenia mägikülas Rosia Montanas. Projekti on investeeritud juba üle 350 mln. dollari, samas on see leidnud vastuseisu nii poliitikute kui ka aktivistide hulgas. Kompanii plaanidest, 2000. a. toimunud keskkonnakatastroofist Põhja-Rumeenias. Kaart

  14. Selected works of Frank Lloyd Wright%赖特作品

    Institute of Scientific and Technical Information of China (English)

    赖特

    2006-01-01

    赖特,我认识你,一位现代建筑的大师。今天,我以为,我的以为确是被人误导。古根汉姆,你为自己建造,在那里,艺术品并不重要,你迫使人们歪着脖子看着珍藏品,你迫使管理员无所措手脚。你用流水线的原则,你用停车库的原则,做成那只圆形的螺蛳壳,我年轻时候的惊奇与赞叹已不在。还有,你那张视平线低低的落泉山庄照片,用句今天的话,真可谓精艳登场。好几代教师,捧着这两件作品,赞叹不已,你却Passedaway,一旁冷眼地看着,默默不语。如果,真有灵魂的话,我想跟你商量,商量,要知道,我关注你时间很长,我觉得,他们讲的,他们的赞扬,都是假象。你呀,其实是个十足的工匠,你跟路斯很不一样,装饰是你的一技之长,你还那么中庸,在你的设计言语里面,无论西方,东方,只见你的房子,趴着长,横着长。我看见,你那里有中世纪的玻璃彩画,我看见,你那里有着东、西不分的立柱横梁。我又发现,你那么热衷于手工艺制作的家具与室内装潢。东方的地毯,异教徒的雕塑,阿拉伯的卷草纹样,……你的制作是那样的精细、典雅。有时,材料与质感又是那样地朴野、自然,令人向往。一百年都快过去了,他们还是那样光彩夺目,令人敬仰。你,就是一个Master,一个勤于劳作的工匠,你的魅力在...

  15. Iga 20 km järel erateater / Harald Redmer, Frank Heuel ; interv. Mari Kolle

    Index Scriptorium Estoniae

    Redmer, Harald

    2002-01-01

    18.-21. veebr. viibisid Eestis külalised saksa erateatritest - näitleja ja produtsent H. Redmer teatrist phoenix 5 Münsterist ja teatri fringe-ensemble lavastaja ning kunstiline juht F. Heuel Bonnist

  16. 76 FR 43549 - Office of Thrift Supervision Integration; Dodd-Frank Act Implementation

    Science.gov (United States)

    2011-07-21

    ... (HOLA) with respect to Federal savings associations must be made in accordance with the laws and legal... under the HOLA to conform to those applicable to national banks, we proposed adding new Sec. Sec. 7.4010... holding in Barnett, including those based on the HOLA, also continue to be effective. \\29\\ One...

  17. 78 FR 30941 - Frank Russell Company, et al.; Notice of Application

    Science.gov (United States)

    2013-05-23

    ... where the fees are disclosed to other prospective and existing customers. Applicants submit that the... than quarterly, with information about the profitability of such Adviser on a per-Fund basis. The information will reflect the impact on profitability of the hiring or termination of any money manager...

  18. Ideaalbeeld freesia op de kop (interview met Frank van der Helm)

    NARCIS (Netherlands)

    Sleegers, J.; Helm, van der F.P.M.

    2012-01-01

    Een onderzoek naar bodemisolatie in freesia heeft niet het bedoelde effect opgeleverd. Maar het heeft wel het ideaalbeeld van de plant op zijn kop gezet. De schraalste planten leverden de mooiste takken op.

  19. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric Aβ and frank neuronal loss

    Science.gov (United States)

    Cohen, Robert M.; Rezai-Zadeh, Kavon; Weitz, Tara M.; Rentsendorj, Altan; Gate, David; Spivak, Inna; Bholat, Yasmin; Vasilevko, Vitaly; Glabe, Charles G.; Breunig, Joshua J.; Rakic, Pasko; Davtyan, Hayk; Agadjanyan, Michael G.; Kepe, Vladimir; Barrio, Jorge; Bannykh, Serguei; Szekely, Christine A.; Pechnick, Robert N.; Town, Terrence

    2013-01-01

    Alzheimer’s disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neuronal loss (Selkoe, 2001). The ‘amyloid cascade hypothesis’ posits that cerebral amyloid sets neurotoxic events into motion that precipitate Alzheimer dementia (Hardy and Allsop, 1991). Yet, faithful recapitulation of all AD features in widely used transgenic (Tg) mice engineered to overproduce Aβ peptides has been elusive. We have developed a Tg rat model (line TgF344-AD) expressing mutant human amyloid precursor protein (APPsw) and presenilin 1 (PS1ΔE9) genes, each independent causes of early-onset familial AD. TgF344-AD rats manifest age-dependent cerebral amyloidosis that precedes tauopathy, gliosis, apoptotic loss of neurons in the cerebral cortex and hippocampus, and cognitive disturbance. These results demonstrate progressive neurodegeneration of the Alzheimer type in these animals. The TgF344-AD rat fills a critical need for a next-generation animal model to enable basic and translational AD research. PMID:23575824

  20. Juhan Parts : kasvu nimel tuleb kõvasti pingutada / Juhan Parts ; interv. Frank Sprenk-Dorn

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2007-01-01

    Majandus- ja kommunikatsiooniminister vastab küsimustele, mis olid tema arvates möödunud aastal Eesti majandust kõige enam mõjutanud sündmused ja mis muutused majanduses jäid möödunud aasta jooksul kõige enam silma nii negatiivse kui ka positiivse poole pealt

  1. 1995 - Black & White - Addi, Frank, Grand, Lam, Wash (0.5m)

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The VTORTHO_0_5M_PAN_1995 data includes panchromatic (black and white) orthophotography (orthophoto) at 1:5000 scale (0.5 meter cell resolution)....

  2. Reappraising Positivism and Education: The Arguments of Philippa Frank and Herbert Feigl

    Science.gov (United States)

    Matthews, Michael R.

    2004-01-01

    This paper documents some of the "bad press" that Positivism has received in science education; it delineates the varied, and sometimes contradictory, ways in which educationalists characterize positivism; it indicates that Constructive shares the same philosophical commitments as the instrumentalist tradition in positivism; and it suggests that…

  3. Dilemas de autenticidad: la restauración de la Casa Freeman de Frank Lloyd Wright

    OpenAIRE

    Chusid, Jeffrey M.

    2014-01-01

    [EN] This article presents a brief a overview illustrating the process for commissioning, designing and build-ing this house using the characteristic prefabricated blocks of Wright’s California period. It also describes the subsequent life of the building, a nerve centre for the artistic avant-garde of Los Angeles, featuring ma-jor modifications by well-known architects including Rudolph Schindler, Gregory Ain and John Lautner. This text reflects the extreme technical complexity of restoring ...

  4. FRANK A. VANDERLIP AND THE NATIONAL CITY BANK DURING THE FIRST WORLD WAR

    OpenAIRE

    Priscilla Roberts

    2002-01-01

    This essay focuses on the First World War policies of the National City Bankof New York, drawing attention to the internal disputes within the bank over war financing. Some historians have suggested that during the First World War New York banks associated with the National City Bank favored fierce competition with the Allied powers for markets and overseas investment opportunities, whereas those linked to J. P Morgan and Company preferred cooperation with the Allied powers, concentrating upo...

  5. Interfacial free energy and medium range order: Proof of an inverse of Frank's hypothesis

    Science.gov (United States)

    Lee, Geun Woo; Cho, Yong Chan; Lee, Byeongchan; Kelton, Kenneth F.

    2017-02-01

    We study the relation of crystal-liquid interfacial free energy and medium range order in the quasicrystal-forming T i37Z r42N i21 liquid from undercooling experiment and ab initio molecular dynamics (MD) simulation. Adding a small amount of Ag to the liquid significantly reduces the degree of undercooling, which is suggestive of small interfacial free energy, and thus very similar atomic configuration between the liquid and the icosahedral quasicrystal phases. Using ab initio MD study, we find that Ag atoms predominantly form a bond with Zr atoms in the short range and, further, Ag-Zr pairs are extended in the liquid, as a medium range order which is identical to the global structural feature reported recently [Liu et al., Phys. Rev. Lett. 105, 155501 (2010)], 10.1103/PhysRevLett.105.155501. This result may expect extremely small undercooling if the icosahedral medium range order exists in a liquid forming an icosahedral quasicrystal, which implies the ambiguity of clear distinction of heterogeneous and homogeneous nucleation.

  6. Las hijas de Ana Frank. Diarios íntimos y adolescencia.

    OpenAIRE

    Alberca, Manuel

    2012-01-01

    In this paper I analyse three diaries which belong to my book of personal diaries, La escritura invisible. Testimonios sobre el diario íntimo (Sendoa 2000), which I collected from 2000 to 2006. These diaries were written by Spanish girls from 1970s to 1990s. Although it would not be exact to generalize, nor jump into into general conclusions since we are dealing with a very wide subject, such as the diaries of adolescents, or their reading or study, we present here some relevant aspects conne...

  7. On Frank Ankersmit's postmodernist theory of historical narrativity - Reply to Professor Saari

    NARCIS (Netherlands)

    Ankersmit, FR

    2005-01-01

    In my reply I focus on Professor Saari's criticism of my views on the notions of historical truth, reference and meaning. I argue that the commonsense conceptions of truth and reference as used by Professor Saari are insufficient for achieving a correct understanding of the writing of history and th

  8. Early phase in e-money development: from Edvard Bellamy to Frank Macknamary

    Directory of Open Access Journals (Sweden)

    O.S. Vysochan

    2016-03-01

    Full Text Available The article examines the phases of e-money development from the first mentioning of «a credit card» in literary sources to the appearance of Diners Club which preceded modern credit cards. The author has used the historical and geographic method for the decomposition of the early phase in the e-money development concerning the basic motives that induced emitters to develop and implement particular credit-payment systems. The article singles out three stages within the early phase of the e-money development, namely, the beginning of the ХХ-th century (supplying with short-term credits to obtain consumer’s goods, from 1920 to 1940 (guarantee of consumer’s loyalty to a brand, increasing the safety of clearing transactions by payer’s authorization, and 1950-ies (the use of the same credit for payment to various enterprises. It establishes the main features of the early phase in the e-money development; they are such as the absence of the necessary technical supply; emission, sale, guaranty on credits, on the cards issued take place outside the banking system; the lack of corporation credit card segment; the limitation of the application area; the low level of safety of the transactions accomplished.

  9. Systematically Important Banks and Increased Capital Requirements in the Dodd-Frank Era

    DEFF Research Database (Denmark)

    Lutz, Chandler

    2016-01-01

    This paper analyzes the effects of new capital requirements for systematically important financial institutions proposed by the Federal Reserve on September 8, 2014. Results from an event study indicate this announcement led to lower abnormal initial stock returns for systemically important...

  10. Volumetric Muscle Loss: Persistent Functional Deficits Beyond Frank Loss of Tissue

    Science.gov (United States)

    2014-09-18

    approximately at the midline of the TA muscle belly) using a Piezoelectric dental saw with a blade less than 0.5mm wide. For bone stabilization after injury, a...electrodes was implanted in each leg around the peroneal nerve. Legs were tested separately and in random- ized order. The foot was strapped using silk

  11. Religious Franks. Religion and power in the Frankish Kingdoms. Studies in honour of Mayke de Jong

    NARCIS (Netherlands)

    Meens, R.M.J.; Espelo, D.B. van; Hoven van Genderen, B.; Raaijmakers, J.; Renswoude, I. van; Rhijn, C. van

    2016-01-01

    This volume in honour of Mayke De Jong offers twenty-five essays focused upon the importance of religion to Frankish politics, a discourse to which De Jong herself has contributed greatly in her academic career. The prominent and internationally renowned contributors offer fresh perspectives on vari

  12. Neutron physics at the JINR: 60 years of the I M Frank Laboratory of Neutron Physics

    Science.gov (United States)

    Lychagin, E. V.; Kozlenko, D. P.; Sedyshev, P. V.; Shvetsov, V. N.

    2016-03-01

    26 March 2016 marked 60 years since the Joint Institute for Nuclear Research was founded in 1956 and within which the Laboratory of Neutron Physics was established. Already four years later, in 1960, the world's first pulsed fast reactor (known by its Russian acronym as IBR) operating in the periodic mode was put into operation, followed in 1984 by IBR-2. The research achievements over the last decade are summarized, the state-of-the-art laboratory hardware is discussed, and the prospects for the future are reviewed.

  13. Karm võitlus Euroopa Eldorado eest - kellele kuulub Rumeenia kuld? / Frank Sprenk-Dorn

    Index Scriptorium Estoniae

    Sprenk-Dorn, Frank

    2008-01-01

    Kanada päritolu kompanii Gabriel Resources Ltd soovib alustada kulla kaevandamist Rumeenia mägikülas Rosia Montanas. Projekti on investeeritud juba üle 350 mln. dollari, samas on see leidnud vastuseisu nii poliitikute kui ka aktivistide hulgas. Kompanii plaanidest, 2000. a. toimunud keskkonnakatastroofist Põhja-Rumeenias. Kaart

  14. USA erisaadik : USA investorid Eestis rahul / J. Frank Mermoud ; interv. Sirje Rank

    Index Scriptorium Estoniae

    Mermoud, J. Frank

    2004-01-01

    Ameerika Ühendriikide välisministri nõunik ja erisaadik majandusküsimustes kiidab Eesti edu, räägib USA investorite rahuolust Eesti majanduskeskkonnaga ja väljendab muret Euroopa Liidu kavade pärast maksude ühtlustamiseks

  15. Frank A. Beach award. Homologies of animal and human sexual behaviors.

    Science.gov (United States)

    Pfaus, J G

    1996-09-01

    Theoretical models of animal and human sexual behavior have evolved from two very different literatures, yet they contain many common behavioral components that may reflect the action of similar neuroendocrine and neurochemical systems. The study of animal sexual behavior has been largely concerned with mechanisms that underlie the pattern of consummatory behaviors observed during copulation, behaviors that tend to be highly stereotyped, sexually differentiated, and species-specific. There are important species differences in the behavioral topography, endocrine control, and neural substrates of consummatory behaviors, which tend to be extreme when comparing animals and humans. Although this has led to an increased interest in comparative animal behavior, it has also helped to foster a general perception that animals and humans are fundamentally different. In contrast to consummatory behaviors, appetitive behaviors (which serve to bring animals and humans into contact with sexual incentives) are more flexible, less sexually differentiated, and less species-specific and span a variety of situations other than sexual interactions. Appetitive behaviors are thus viewed as "sexually specific" when they are displayed under sexual circumstances and reinforced by sexual incentives. Interestingly, an appetitive/consummatory dichotomy has emerged in the human literature which distinguishes measures of sexual desire or arousal from "performance" measures of masturbation or copulation. In fact, sexual desire, which reflects fantasy and behavioral excitement, has been further differentiated from sexual arousal, which reflects genital blood flow. The present analysis attempts to pull together these seemingly disparate literatures into a coherent theoretical framework that emphasizes similarities and differences in the structure of sexual behavior across rats and humans.

  16. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric Aβ and frank neuronal loss

    OpenAIRE

    2013-01-01

    Alzheimer’s disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neuronal loss (Selkoe, 2001). The ‘amyloid cascade hypothesis’ posits that cerebral amyloid sets neurotoxic events into motion that precipitate Alzheimer dementia (Hardy and Allsop, 1991). Yet, faithful recapitulation of all AD features in widely used transgenic (Tg) mice engineered to overproduce Aβ peptides has been elusive. We have developed a Tg rat model (line TgF344-AD) expressing...

  17. Edgar Savisaar : aprill mõjutab meid aastaid / Edgar Savisaar ; interv. Frank Sprenk-Dorn

    Index Scriptorium Estoniae

    Savisaar, Edgar, 1950-

    2007-01-01

    Tallinna linnapea hinnangul mõjutasid möödunud aastal Eesti majandust kõige enam aprillisündmused, Schengeni viisaruumiga liitumise mõju on sel aastal tühine. Ta loodab, et järgmisel aastal saab Eesti valitsuse, kelle jaoks on kõik majandusvaldkonnad tähtsad

  18. Iga 20 km järel erateater / Harald Redmer, Frank Heuel ; interv. Mari Kolle

    Index Scriptorium Estoniae

    Redmer, Harald

    2002-01-01

    18.-21. veebr. viibisid Eestis külalised saksa erateatritest - näitleja ja produtsent H. Redmer teatrist phoenix 5 Münsterist ja teatri fringe-ensemble lavastaja ning kunstiline juht F. Heuel Bonnist

  19. Leda kujutis : [luuletused] / Frank ÒHara ; tõlk. Hasso Krull

    Index Scriptorium Estoniae

    ÒHara, Frank

    2008-01-01

    Sisu: Leda kujutis ; Homoseksuaalsus ; Sammu kaugusel neist ; Päeva-leedi surmapäev ; Luuletus ; Vastus Voznessenskile & Jevtushenkole ; Mary Desti Perse ; Suvetuuled. Elu- ja loomeloolisi andmeid autori kohta lk. 523

  20. Dodd-Frank and risk-taking: reputation impact in banks

    Directory of Open Access Journals (Sweden)

    Ezelda Swanepoel

    2017-03-01

    Full Text Available The banking industry plays a significant role in both the financial system and economy as a whole. By 2012, the US banking system owned US $14.45 trillion in assets. However, the importance of the banking system stretches beyond its mere size. Numerous studies have indicated that the health of this sector has significant effects on overall economic activity, as well as the size and persistence of economic cycles. For the purposes of this paper, the researchers measured the correlation between current legislation, risk-taking, market value, and reputation. This was performed by calcula-ting Z-scores to determine bank risk-taking. The Z-scores were correlated to market value to determine its impact. Reputable firm behavior was used to determine the correlation between market value and reputation. The statistical package for Social Sciences was used to perform ANOVA analysis of share value and Z-scores. A literature review was conducted to determine the reputational impact. It was determined that current legislation might have a desired result on risk-taking, that risk-taking might not have an impact on market value, and that reputation might have an impact on market value.

  1. Frankly, None of Us Know What Dementia Is: Dementia Caregiving Among Iranian Immigrants Living in Sweden.

    Science.gov (United States)

    Antelius, Eleonor; Kiwi, Mahin

    2015-01-01

    In quite a short amount of time, Sweden has gone from being a relatively homogeneous society to a multicultural one, with a rapid expansion of immigrants having culturally and linguistically diverse (CALD) backgrounds growing old in Sweden. This is particularly interesting in relation to studying age-related dementia diseases. Research shows that not only do CALD persons with dementia diseases tend to mix languages, have difficulties with separation of languages, or revert to speaking only their native tongue as the disease progresses, but they also show tendencies to experience that they live in the cultural environment in which they were brought up, rather than in the current Swedish one. In this article, we explore findings in relation to one such CALD group in Sweden, Iranians. The article is empirically driven and based on data gathered in 2 separate settings with specific ethnocultural profiles, offering dementia care with Middle Eastern, Arab, and/or Persian profile. Observations were carried out in combination with semistructured in-depth interviews (n = 66). By using a combination of content and ethnographic analysis, 4 main findings related to ethnocultural dementia care were elucidated. These include (a) a wider recognition of people from different CALD backgrounds possibly having different perceptions of what dementia is, (b) a possibility that such ascribed meaning of dementia has a bearing on health maintenance and health-seeking behavior as well as the inclination to use formal services or not, (c) choosing to use formal service in the forms of ethnoculturally profiled dementia care facility seems to relate to being able to "live up to ideals of Iranian culture," and (d) "culture," however ambiguous and hotly debated a concept it is, appears to be a relevant aspect of people's lives, an aspect that is both acquired as well as ascribed to oneself and to others. As such, we argue that culture needs to be further addressed in relation to dementia care in multicultural societies because ascribing culture boxes people in as well as out. In addition, ethnocultural contextualization of dementia care needs to be understood in relation to this because it affects the care provided.

  2. Juhan Parts : kasvu nimel tuleb kõvasti pingutada / Juhan Parts ; interv. Frank Sprenk-Dorn

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2007-01-01

    Majandus- ja kommunikatsiooniminister vastab küsimustele, mis olid tema arvates möödunud aastal Eesti majandust kõige enam mõjutanud sündmused ja mis muutused majanduses jäid möödunud aasta jooksul kõige enam silma nii negatiivse kui ka positiivse poole pealt

  3. Ansip : kõige olulisem on Schengeniga liitumine / Andrus Ansip ; interv. Frank Sprenk-Dorn

    Index Scriptorium Estoniae

    Ansip, Andrus, 1956-

    2007-01-01

    Peaminister Andrus Ansip vastab küsimustele, mis sündmused mõjutasid tema arvates möödunud aastal Eesti majandust kõige enam, mis muutused Eesti majanduses jäid talle möödunud aastal nii negatiivse kui ka positiivse poole pealt silma, millega tuleb järgmise aasta peale mõeldes arvestada

  4. Edgar Savisaar : aprill mõjutab meid aastaid / Edgar Savisaar ; interv. Frank Sprenk-Dorn

    Index Scriptorium Estoniae

    Savisaar, Edgar, 1950-

    2007-01-01

    Tallinna linnapea hinnangul mõjutasid möödunud aastal Eesti majandust kõige enam aprillisündmused, Schengeni viisaruumiga liitumise mõju on sel aastal tühine. Ta loodab, et järgmisel aastal saab Eesti valitsuse, kelle jaoks on kõik majandusvaldkonnad tähtsad

  5. Means for load variation during echocardiographic assessment of the Frank-Starling relationship.

    Science.gov (United States)

    Atkins, B Z; Silvestry, S C; Davis, J W; Kisslo, J A; Glower, D D

    1999-10-01

    Because minimally invasive methods of preload variation are not validated for load-insensitive indexes of cardiac performance, intravenous nitroglycerin (NTG), phenylephrine, and saline solution (VOL) boluses were used in blocked and intact autonomic states to alter load and were compared with vena caval occlusion in the assessment of preload recruitable stroke work relationships between stroke work and left ventricular end-diastolic volume in dogs. In both autonomic states NTG and VOL produced comparable linear relationships. NTG and saline solution were combined with noninvasive measurements of left ventricular pressure and volume to construct echocardiographic relationships between stroke work and left ventricular end-diastolic cross-sectional area; NTG produced linear relationships similar to vena caval occlusion. Therefore NTG and VOL reliably alter load in constructing preload recruitable stroke work relationships, and NTG may be used with noninvasive measurements to provide load-insensitive estimates of cardiac function in a minimally invasive manner.

  6. Geometric and muscle physiological factors of the Frank-Starling mechanisms.

    Science.gov (United States)

    Jacob, R; Dierberger, B; Gülch, R W; Kissling, G

    1993-01-01

    The relation between left-ventricular stroke volume (SV) and end-diastolic volume (EDV) was determined based on angiocardiographic measurements in 10 open-chest minipigs under varying filling conditions (blood letting or infusions). The results were compared with a theoretical relation calculated under the assumption of varying EDV but constancy of myocardial properties. In contrast to the linear increase of SV as a function of EDV as found in the animal experiments, the calculated curve reveals a maximum near the normal operating point with a decrease in the range of higher EDV. It can be concluded that the well-known increase of SV with increasing ventricular filling, beyond the normal EDV, is almost completely due to muscle physiological factors (mainly increase in Ca2+ sensitivity of the contractile apparatus), whereas the decrease of SV in the range of low filling pressure is mainly due to the geometrical conditions.

  7. Excerpts from field diary of Frank L. Beals, Kodiak, Alaska, 1944

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Wildlife Observations, occurrences, documentation from Saint Matthews, Saint Paul (St. Paul) and Pribilofs Islands. Mammals, birds primarily documented June through...

  8. Mechanisms of the Frank-Starling phenomena studied in intact hearts.

    Science.gov (United States)

    Burkhoff, D; Stennett, R A; Ogino, K

    1995-01-01

    The impact of ventricular volume on the relationship between intracellular calcium and ventricular pressure under steady-state conditions was determined in intact ferret hearts. The results reveal major quantitative differences and minor qualitative differences between these relations and those previously measured in isolated intact and skinned cardiac muscle. The importance of these differences is discussed within the context of developing a comprehensive mechanistic theory to describe load-dependence of the intact ventricle.

  9. RB-10-07 Lophelia II 2010: Oil Seeps and Deep Reefs on NOAA Ship Ronald H. Brown in the Gulf of Mexico between 20101014 and 20101104

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Lophelia II project involves exploration and research of the northern Gulf of Mexico deepwater natural and artificial hard bottom habitats with emphasis on coral...

  10. Ronald Reagan's Re-formulation of the Rhetoric of War: Analysis of the "Zero Option,""Evil Empire," and "Star Wars" Addresses.

    Science.gov (United States)

    Goodnight, G. Thomas

    1986-01-01

    Analyzes speeches in which Reagan challenges the following convention: science will continue to create technologically advanced weapons against which no effective defense will be developed, making deterrence through an assured retaliatory capability the only possible defense. Textual analysis reveals how public discourse can achieve unities of…

  11. Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (HSU Ronald Construction Co. - Jacobson & Son Yard Service). Part 10

    Science.gov (United States)

    1994-03-01

    w i :1c ’ - )4 11 160 Ho c o 0 0 0 0 ON0r. a-H 6 a I 0O w 11) z C.) u. U.. Z ) ac cc CA Cie ’ qNE ImO co HZj 13 0 Z x W- 0 z 00 1-- 0 LA. LP. 43...D 0I W.-4 No m-0 -t4 :) tD (OOW( N W .-i ONNNNNNNNNI N O~ ve Ye - u c-NNNNNN N -c 1 00.-4 N .3000 NO 0 000WMW00 ON ccɘc4 04 4c4 4 04c4(4c4< N u- I NO0...0O Ci cc(0 cc ,1%0 t 0 . >0 1 UI 00 C c 114c I- -c M - 1-- f- I- I ,-4 Ica(00- HZj 1 0. UA UN) UN U(U U3 N. I (00.-i If ~cV ;c44 4 UNN cCf M0 L O ;0(4

  12. Oceanographic profile temperature, salinity and other measurements using CTD taken from NOAA Ship RONALD H. BROWN in the North Atlantic and Equatorial Atlantic in 2013 (NODC Accession 0120701)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2013 PIRATA Northeast Extension (PNE) and Aerosols and Ocean Science Expedition (AEROSE) Cruise RB-13-01 was designed to: (1) collect a suite of oceanographic...

  13. An Old and Reliable Authority: An Act for the Preservation of American Antiquities, by Raymond Harris Thompson, with contributions by Ronald Freeman Lee and George Alexander Grant, 2000

    Directory of Open Access Journals (Sweden)

    Jonathan E. Reyman

    2001-05-01

    Full Text Available "An old and reliable authority" is how George Benjamin Hartzog, Director of the National Park Service (1964-1972, characterized the Antiquities Act of 1906. And it has been quite a reliable authority - and a remarkable one. Since its inception presidents have used it to establish 36 historic areas as national monuments and 51 natural areas; special acts of Congress have authorized another 28 national monuments (pp.251-253. President Theodore Roosevelt signed the Antiquities Act Bill into law on June 8, 1906 (p. 241. Just 22 days later, on June 30 1906, Roosevelt signed the bill to establish Mesa Verde National Park, the first national park specifically created to protect antiquities (p. 243. The Antiquities Act of 1906 also served as the basis for later federal legislation, e.g., Historic Sites Act of 1935, the National Historic Preservation Act of 1966, the 1979 Archaeological Resources Protection Act, and the creation of National Survey of Historic Sites and Buildings in 1957 (pp. 193, 3 1 6.

  14. Library holdings for Lophelia II 2010 on the R/V Ronald H. Brown in the Gulf of Mexico between October 15, 2010 and November 05, 2010

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Library Catalog may include: Data Management Plans, Cruise Plans, Cruise Summary Reports, Scientific "Quick Look Reports", Video Annotation Logs, Image Collections,...

  15. Underway meteorological, navigational, physical and time series data collected aboard NOAA Ship Ronald H. Brown in the Bering Sea on 2015-09-04 (NCEI Accession 0137446)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0137446 contains raw underway meteorological, navigational, physical and time series data logged by the Scientific Computer System (SCS) aboard NOAA...

  16. Freedom's law by Ronald Dworking (Chinese translation Ⅱ)%自由的法:美国宪法的道德解读(导言·续)

    Institute of Scientific and Technical Information of China (English)

    罗纳德·德沃金

    2001-01-01

    @@ 人民 我们常说在一个民主制度中政府来自于人民,这里的人民是指,人们集体行事,比如说选举领导,个人不能独断行事.然而,有两种集体行为必须区分:即统计性的(statistical)和共同兼顾的(communal).我们对多数主义前提的看法主要决定于民主政府择取何种集体行为.另外,群体中的个体成员独立行事,也就是说个体不具有作为一个群体的行动意识,而群体的行动只是起到个体行为中的某些功能(粗略的或特别的),这种集体行为被称之为统计性的.

  17. 2008 Küresel Krizinin Kökeninde Yatan Hatalar ve Dodd-Frank Kanunu Düzenlemeler(The Origin Mistakes of the 2008 Global Crisis and Dodd-Frank Act Regulations

    Directory of Open Access Journals (Sweden)

    Hülya KIRCI

    2016-08-01

    Full Text Available There are various scientific publishing which explains the reasons that caused 2008 crisis to emerge, yet, it is observed that a detailed study has not been done to put forth breeding mistakes of the crisis. Whilst,any reason that effects the crisis to break out is a result of a previously done mistake(s. This study is prepared with the aims; considering to be important to prevent probable crisis to clarify the bonds between the mistakes and reasons , previously done mistakes before the crisis and reasons for crisis developed by those mistakes, contribute to satisfying the need in the literature, and to examine the precautions taken by the USA to put away the reasons for the crisis. It is obsreved that the reasons breeding the crisis are arised from a series of chain mistakes starting with liberal policies and ends in focusing on the strong regulations for the management of financial crisis policies instead of liberal policies in the post crisis period

  18. 75 FR 62718 - Disclosure for Asset-Backed Securities Required by Section 943 of the Dodd-Frank Wall Street...

    Science.gov (United States)

    2010-10-13

    ... 15Ga-1 3. Disclosures Required by Proposed Rule 15Ga-1 4. Proposed Form ABS-15G 5. Offshore Sales of.... Request for Comment VII. Consideration of Burden on Competition and Promotion of Efficiency, Competition...-compliant asset. The effectiveness of the contractual provisions related to representations and warranties...

  19. Frank Isakson Prize Talk: Superfluid and normal-fluid densities in the cuprate superconductors from infrared spectroscopy

    Science.gov (United States)

    Tanner, D. B.

    Measurements for a number of cuprate families of optical reflectance over a wide spectral range (far-infrared to ultraviolet) have been analyzed using Kramers-Kronig analysis to obtain the optical conductivity σ (ω) and (by integration of the real part of the conductivity) the spectral weight of low- and mid-energy excitations. For the Kramers-Kronig analysis to give reliable results, accurate high-frequency extrapolations, based on x-ray atomic scattering functions, were used. When the optical conductivities of the normal and superconducting states are compared, a transfer of spectral weight from finite frequencies to the zero-frequency delta-function conductivity of the superconductor is seen. The strength of this delta function gives the superfluid density, ρs. In a clean metallic superconductor the superfluid density is essentially equal to the conduction electron density. The cuprates in contrast have only about 20% of the a b-plane low-energy spectral weight in the superfluid. The rest remains in finite-frequency, midinfrared absorption. In underdoped materials the superfluid fraction is even smaller. There are two ways to measure ρs, using either the partial sum rule for the conductivity or by examination of σ2 (ω) . Comparison of these two estimates of the superfluid density shows that 98% of the a b-plane superfluid density comes from energies below 0.15 eV. Many students, postdocs, and materials preparers have contributed to this work; to all I am very grateful.

  20. 赖特的建筑思想研究%On Architectural Thought of Frank Lloyd Wright

    Institute of Scientific and Technical Information of China (English)

    王发堂

    2011-01-01

    赖特建筑思想的核心就是有机建筑.一般来说,有机建筑不仅是草原式住宅的合乎情理的逻辑发展,同时还吸收了"形式服从功能"的合理内核.有机建筑从理论层面上来讲,是处于建筑理论边缘的民间智慧,因此在赖特身后都没有上升或吸纳到主流思想之中.如果以建筑师的影响力作为评判他历史地位的主要指标的话赖特所获的声誉就与他的贡献不相称.密斯和柯布西耶有适应工业社会而发展出来的建筑思想.而赖特有回避工业革命而退回归农业传统倾向,都削弱了赖特建筑思想的影响力.

  1. 76 FR 4207 - Orderly Liquidation Authority Provisions of the Dodd-Frank Wall Street Reform and Consumer...

    Science.gov (United States)

    2011-01-25

    ... the rear of the 550 17th Street Building (located on F Street) on business days between 7 a.m. and 5 p..., it will issue an order authorizing the Secretary to appoint the FDIC as receiver.\\2\\ If the court... stability of the United States in a manner that mitigates such risk and minimizes moral hazard.'' The...

  2. [A country doctor: a proposal of an ethical approach in the 125th anniversary of Frank Kafka's birth].

    Science.gov (United States)

    Alvarez-Díaz, Jorge Alberto

    2008-01-01

    Within the framework of the 125 anniversary of the birth of Franz Kafka we discuss his work as a patient affected by tuberculosis. This essay outlines a review of Kafka as a writer and explains the meaning of the term "Kafkaesque". We put forward a commentary on the ethics expressed in a short story entitled A country doctor. An interpretation of Kafka must involve the notion of responsibility, a theological concept that is then followed by the legal context. Finally, Kafka embraces an ethical approach expressed in his work.

  3. 77 FR 16227 - Frank Myers AutoMaxx, LLC; Analysis of Proposed Consent Order To Aid Public Comment

    Science.gov (United States)

    2012-03-20

    ... that your comment does not include any sensitive personal information, like anyone's Social Security... order to purchase another vehicle, respondent will pay off the balance of the loan on the trade-in... balance on the vehicle exceeds the vehicle's value) in order to purchase another vehicle, respondent...

  4. Candida and candidiasis in HIV-infected patients: where commensalism, opportunistic behavior and frank pathogenicity lose their borders.

    Science.gov (United States)

    Cassone, Antonio; Cauda, Roberto

    2012-07-31

    In this era of efficacious antiretroviral therapy and consequent immune reconstitution, oropharyngeal and esophageal candidiasis (OPC and OEC) still remain two clinically relevant presentations in the global HIV setting. Both diseases are predominantly caused by Candida albicans, a polymorphic fungus which is a commensal microbe in the healthy individual but can become an aggressive pathogen in a debilitated host. Actually, C. albicans commensalism is not the result of a benign behavior of one of the many components of human microbiota, but rather the result of host's potent innate and adaptive immune responses that restrict the growth of a potentially dangerous microrganism on the epithelia. An important asset guarding against the fungus is the Th17 functional subset of T helper cells. The selective loss of these cells with the progression of HIV infection causes the decay of fungal containment on the oral epithelium and allows C. albicans to express its pathogenic potential. An important part of this potential is represented by mechanisms to evade host immunity and enhance inflammation and immunoactivation. In C. albicans, these mechanisms are mostly incorporated into and expressed by characteristic morphogenic transitions such as the yeast-to-hyphal growth and the white-to-opaque switch. In addition, HIV infection generates an 'environment' selecting for overexpression of the virulence potential by the fungus, particularly concerning the secreted aspartyl proteinases (Saps). These enzymes can degrade critical host defense components such as complement and epithelial defensive proteins such as histatin-5 and E-cadherin. It appears that part of this enhanced Candida virulence could be induced by the binding of the fungus to HIV and/or induced by HIV proteins such as GP160 and tat. Both OPC and OEC can be controlled by old and new antimycotics, but in the absence of host collaboration, anticandidal therapy may become ineffective in the long run. For these reasons, new therapeutics targeting virulence factors and specific immune interventions are being addressed. Among these new approaches, vaccination is a promising one. Two subunit vaccines based on antigens dominantly expressed by C. albicans in vivo, that is the Als3 adhesin and Sap2, have recently undergone phase 1 clinical trials. Overall, studies of Candida and candidiasis in the HIV-positive patient while certainly contributing to a more effective control of the microorganism may also provide useful information on HIV-host relationship itself that can assist the fight against the virus.

  5. The Heterotopias in Frank Kafka's Fiction%卡夫卡小说中的另类空间

    Institute of Scientific and Technical Information of China (English)

    冯亚琳

    2009-01-01

    卡夫卡的小说是一种特殊的空间叙事,这不仅表现在作品的叙述结构上,更表现在小说中人物与空间的关系上.本文分析了卡夫卡小说中两种典型的空间模式:囚室式空间和交叠式空间,试图说明现代人在空间感知中的危机体验.

  6. Miks sponsoreerivad ettevõtted suurüritusi? / Frank Svenhard, Liivi Tadolder ; interv. Annika Rõõmus

    Index Scriptorium Estoniae

    Svenhard, Frank

    2006-01-01

    ALD Automotive Baltikumi tegevdirektor ja AS-i Liviko turundusjuht valikutest sponsoreerimisel, koostööst sponsoreeritavate organisatsioonidega, rahvusvahelise juhtimiskonverentsi EC2006 toetamisest

  7. 78 FR 47217 - Proposed Supervisory Guidance on Implementing Dodd-Frank Act Company-Run Stress Tests for Banking...

    Science.gov (United States)

    2013-08-05

    ... Company-Run Stress Tests for Banking Organizations With Total Consolidated Assets of More Than $10 Billion...'') stress tests, applicable to all bank and savings-and-loan holding companies, national banks, state-member... ``$10-50 billion companies''). The guidance discusses supervisory expectations for DFA stress...

  8. Making the Past Relevant to Future Generations. The Work of the Anne Frank House in Latin America

    Science.gov (United States)

    Chyrikins, Mariela; Vieyra, Magdalena

    2010-01-01

    This paper provides the context and outlines the barriers and opportunities for developing promising Holocaust education programmes in Latin America, especially working with diverse communities and societies. In particular, the conflictual history of Latin American and recent democratization processes present opportunities for educational work. It…

  9. Pliegue diagonal del lóbulo auricular (de Frank y su relación con enfermedad coronaria

    Directory of Open Access Journals (Sweden)

    Manuel Agustín Paz

    2014-07-01

    Full Text Available La presencia de pliegue diagonal auricular debe alertar al médico para entender su asociación con la enfermedad cardíaca coronaria y la enfermedad isquémica del corazón, especialmente en aquellos pacientes asintomáticos o pacientes con factores de riesgo tradicionales y no tradicionales. Por lo tanto, esta anormalidad puede ser interpretada como un "marcador cutáneo" de la enfermedad cardíaca coronaria. Este signo también podría servir para identificar mejor a los grupos de alto riesgo cardiovascular y para comenzar con la implementación de las medidas de las estrategias de prevención. Hay otros signos clínicos, además del pliegue de la oreja, que pueden reflejar el envejecimiento arterial y aterosclerosis, independientemente del número, duración o alcance de los factores de riesgo cardiovascular tradicionales. El hallazgo de pliegue auricular no debe sustituir a una historia clínica completa, la aplicación de métodos detallados, exámenes de laboratorio y físicos utilizados con excelente rendimiento en el diagnóstico de la enfermedad coronaria en la actualidad.

  10. Roundtable. Women's magazines under the guise of being frank about sexual problems are sensationalizing them to boost readership.

    Science.gov (United States)

    Khawar, H

    1995-01-01

    Women's magazines in Pakistan edit their content to avoid matters related to female sexuality. Instead, they focus on fashion, child care, general health, and social problems. Only a few stories have emerged about sex clinics in Karachi, the covert homosexual culture, and exploits of well-known people. This reticence makes the dissemination of information about contraception and AIDS difficult. Even the cover models on the magazines must appear clothed in a manner deemed proper. Foreign magazines are available in Pakistan, but they cost more than the local publications.

  11. Biologische grondontsmetting als alternatief voor stomen (interview met Frank van der Helm, projectleider; Marta Streminska verantwoordelijk voor de microbiologie)

    NARCIS (Netherlands)

    Arkesteijn, M.; Helm, van der F.P.M.; Streminska, M.A.

    2013-01-01

    Uit onderzoek is gebleken dat het effect van veertien dagen biologische grond-ontsmetting vergelijkbaar is met een stoombehandeling. Wat de kosten betreft is het eveneens een goed alter-natief. Ondanks goede resultaten pakt de praktijk het nog niet op, omdat er ervaringen zijn geweest met mindere

  12. Critical Percolation Stresses of Random Frank-Read Sources in Micron-Sized Crystals of Superalloys (Preprint)

    Science.gov (United States)

    2011-11-01

    tendency for a saturation stress value, most likely because the experimental size-effect data does not include small enough sizes of micron-sized crystals...D, Gumbsch P, Kraft O, Scripta Mater 2008; 58:587. 7) Tang H, Schwarz KW, Espinosa HD, Acta Mater 2007; 55:1607. 8) Zhou C, Biner S, Lesar R

  13. Critical Percolation Stresses of Random Frank-Read Sources in Micrometer-Sized Crystals of Superalloys (Postprint)

    Science.gov (United States)

    2012-07-09

    controls the yield stress [20]. However, the experimental data [4] do not show any such tendency for a saturation stress value, most likely because the...D M, Parthasarathy T A, Uchic M D, Tang M and Woodward C 2008 Acta Mater. 56 3245 [6] Senger J, Weygand D, Gumbsch P and Kraft O 2008 Scr. Mater. 58

  14. Discussions on Laboratory Testing of Backwards Erosion Piping of Soil: An Interview with John H. Schmertmann and Frank C. Townsend

    Science.gov (United States)

    2014-11-01

    have no idea of knowing if I’ve got 2% penetration or 50% penetration due to just the construction or the way Mother Nature left it. So, that’s why...was thinking if you could have a bellow type of system with a plate , you could lift the whole plate up and make it uniform; but we didn’t have that...had a rectangular plate , and I would have a bellowed system such that the plate would come up and the bellows would keep it sealed down below so I

  15. 76 FR 39278 - Modification of Treasury Regulations Pursuant to Section 939A of the Dodd-Frank Wall Street...

    Science.gov (United States)

    2011-07-06

    ...), including the exception in Sec. 1.197-2(c)(6) for certain rights to receive tangible property or services... and other interest rate derivatives, capturing bid-ask spreads and keeping its market exposure within desired limits (using, if necessary, additional derivatives for this purpose). X uses a...

  16. Identifying and Using Picture Books with Quality Mathematical Content: Moving beyond "Counting on Frank" and "The Very Hungry Caterpillar"

    Science.gov (United States)

    Marston, Jennie

    2014-01-01

    This article by Jennie Marston provides a framework to assist you in selecting appropriate picture books to present mathematical content. Jennie demonstrates the framework by applying three specific examples of picture books to the framework along with examples of activities.

  17. Océanie. Signes de rites, symboles d’autorité de Frank Herreman (éd.)

    OpenAIRE

    Bounoure, Gilles

    2009-01-01

    Publié à l’occasion d’une exposition du même titre présentée à l’Espace culturel ing de Bruxelles du 23 octobre 2008 au 15 mars 2009, ce catalogue vise avant tout à offrir au grand public un échantillon représentatif des arts océaniens à travers une sélection d’objets conservés dans les collections publiques et privées du nord-ouest de l’Europe continentale, qu’il s’agissait de présenter de façon aussi concise et claire que possible. Exposition et catalogue avaient été mis en chantier bien av...

  18. 75 FR 51429 - Definitions Contained in Title VII of Dodd-Frank Wall Street Reform and Consumer Protection Act

    Science.gov (United States)

    2010-08-20

    ... floor; (III) A rate cap; (IV) A rate collar; (V) A cross-currency rate swap; (VI) A basis swap; (VII) A currency swap; (VIII) A foreign exchange swap; (IX) A total return swap; (X) An equity index swap; (XI) An... agreements, contracts, or transactions in foreign currency pursuant to section 2(c)(2).'' Security-Based......

  19. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss.

    Science.gov (United States)

    Cohen, Robert M; Rezai-Zadeh, Kavon; Weitz, Tara M; Rentsendorj, Altan; Gate, David; Spivak, Inna; Bholat, Yasmin; Vasilevko, Vitaly; Glabe, Charles G; Breunig, Joshua J; Rakic, Pasko; Davtyan, Hayk; Agadjanyan, Michael G; Kepe, Vladimir; Barrio, Jorge R; Bannykh, Serguei; Szekely, Christine A; Pechnick, Robert N; Town, Terrence

    2013-04-10

    Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neuronal loss (Selkoe, 2001). The "amyloid cascade hypothesis" posits that cerebral amyloid sets neurotoxic events into motion that precipitate Alzheimer dementia (Hardy and Allsop, 1991). Yet, faithful recapitulation of all AD features in widely used transgenic (Tg) mice engineered to overproduce Aβ peptides has been elusive. We have developed a Tg rat model (line TgF344-AD) expressing mutant human amyloid precursor protein (APPsw) and presenilin 1 (PS1ΔE9) genes, each independent causes of early-onset familial AD. TgF344-AD rats manifest age-dependent cerebral amyloidosis that precedes tauopathy, gliosis, apoptotic loss of neurons in the cerebral cortex and hippocampus, and cognitive disturbance. These results demonstrate progressive neurodegeneration of the Alzheimer type in these animals. The TgF344-AD rat fills a critical need for a next-generation animal model to enable basic and translational AD research.

  20. Kunstivaldkonna tähtsus : seos avalike eesmärkidega / Alberta Arthurs, Frank Hodsoll ; tõlk. Johanna Ross

    Index Scriptorium Estoniae

    Arthurs, Alberta

    2008-01-01

    Originaali pealkiri: The importance of the arts sector : how it relates to the public purpose // The Journal of Arts Management, Law and Society. Vol. 28, nr. 2, lk. 102-108. Lühidalt autoritest lk. 198

  1. Adopting Frank Warren's PostSecret Art Project to Illustrate the Role of Secrets in Interpersonal Communication

    Science.gov (United States)

    Paxman, Christina G.

    2013-01-01

    The exploration of secrets summons the adage that ''what someone doesn't know won't hurt them.'' While this phrase implies that keeping secrets can be advantageous, it also foreshadows another consideration: secrets have the propensity to hurt others (Caughlin, Scott, Miller, & Hefner, 2009). Despite this, the act…

  2. 76 FR 41626 - Certain Orderly Liquidation Authority Provisions under Title II of the Dodd-Frank Wall Street...

    Science.gov (United States)

    2011-07-15

    ... financial stability of the United States (a ``covered financial company'') following the prescribed... liquidation of a covered financial company or to avoid or mitigate adverse effects on the financial stability... of the covered financial company or to avoid or mitigate adverse effects on the financial......

  3. 76 FR 11935 - Death of Army Corporal Frank W. Buckles, the Last Surviving American Veteran of World War I

    Science.gov (United States)

    2011-03-03

    ... Surviving American Veteran of World War I By the President of the United States of America A Proclamation As... veteran of World War I, and in remembrance of the generation of American veterans of World War I, I hereby...

  4. Kunstivaldkonna tähtsus : seos avalike eesmärkidega / Alberta Arthurs, Frank Hodsoll ; tõlk. Johanna Ross

    Index Scriptorium Estoniae

    Arthurs, Alberta

    2008-01-01

    Originaali pealkiri: The importance of the arts sector : how it relates to the public purpose // The Journal of Arts Management, Law and Society. Vol. 28, nr. 2, lk. 102-108. Lühidalt autoritest lk. 198

  5. 76 FR 26787 - Short Sale Reporting Study Required by Dodd-Frank Act Section 417(a)(2)

    Science.gov (United States)

    2011-05-09

    ... maker posts continually at or near the best offer, but does not also post at or near the best bid, the... positions affect the behavior of short sellers and other investors? Would it affect abusive short selling..., would such data reveal the trading strategies of non-abusive short sellers? Could the availability of...

  6. 76 FR 4489 - Disclosure for Asset-Backed Securities Required by Section 943 of the Dodd-Frank Wall Street...

    Science.gov (United States)

    2011-01-26

    ... 229, 232, 240 and 249 RIN 3235-AK75 Disclosure for Asset-Backed Securities Required by Section 943 of...-backed securities offerings. The final rules require securitizers of asset-backed securities to disclose... mechanisms available to investors in an asset-backed securities offering in any report accompanying a credit...

  7. Energetics of the Frank-Starling effect in rabbit myocardium: economy and efficiency depend on muscle length.

    Science.gov (United States)

    Holmes, Jeffrey W; Hünlich, Mark; Hasenfuss, Gerd

    2002-07-01

    We tested the hypothesis that economy and efficiency are independent of length in intact cardiac muscle over its normal working range. We measured force, force-time integral, force-length area, and myocardial oxygen consumption in eight isometrically contracting rabbit right ventricular papillary muscles. 2,3-Butanedione monoxime was used to partition nonbasal oxygen consumption into tension-independent and tension-dependent components. Developed force, force-time integral, and force-length area increased by factors of 2.4, 2.7, and 4.8, respectively, as muscle length was increased from 90% to 100% maximal length, whereas tension-dependent oxygen consumption increased only 1.6-fold. Economy (the ratio of force-time integral to tension-dependent oxygen consumption) increased significantly with muscle length, as did contractile efficiency, the ratio of force-length area to tension-dependent oxygen consumption. The average force-length area-nonbasal oxygen consumption intercept was more than the twice tension-independent oxygen consumption. We conclude that economy and efficiency increase with length in rabbit myocardium. This conclusion is consistent with published data in isolated rabbit and dog hearts but at odds with studies in skinned myocardium.

  8. Radionuclide ventriculographic responses to graded supine and upright exercise: critical role of the Frank-Starling mechanism at submaximal exercise.

    Science.gov (United States)

    Steingart, R M; Wexler, J; Slagle, S; Scheuer, J

    1984-06-01

    To assess the influence of work load and posture on the response to exercise, 25 patients with coronary artery disease (CAD) and 17 normal subjects underwent graded supine and upright exercise radionuclide ventriculography. In both groups, end-diastolic counts increased with supine exercise (p less than 0.001). The ejection fraction and peak systolic pressure-end-systolic volume relation increased in normal subjects (p less than 0.02), but not in patients with CAD. At upright rest, end-diastolic counts decreased in both groups (p less than 0.001) and then increased with exercise (p less than 0.001). The increase in end-diastolic counts was most pronounced on the transition from upright rest to the 150-kpm work load and resulted in a significant increase in stroke counts (p less than 0.05) for both patients with CAD and normal subjects, without a measurable change in the ejection fraction or the peak systolic pressure-end-systolic volume relation. Later in exercise, end-diastolic counts plateaued, and the ejection fraction and the peak systolic pressure, end-systolic volume relation increased only among normal subjects. Thus, low-level upright exercise is highly dependent on the Starling mechanism in both normal subjects and patients with CAD, with enhanced contractility apparent only during more vigorous exercise in normal subjects.

  9. Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: failure of the Frank-Starling mechanism.

    Science.gov (United States)

    Kitzman, D W; Higginbotham, M B; Cobb, F R; Sheikh, K H; Sullivan, M J

    1991-04-01

    Invasive cardiopulmonary exercise testing was performed in 7 patients who presented with congestive heart failure, normal left ventricular ejection fraction and no significant coronary or valvular heart disease and in 10 age-matched normal subjects. Compared with the normal subjects, patients demonstrates severe exercise intolerance with a 48% reduction in peak oxygen consumption (11.6 +/- 4.0 versus 22.7 +/- 6.1 ml/kg per min; p less than 0.001), primarily due to a 41% reduction in peak cardiac index (4.2 +/- 1.4 versus 7.1 +/- 1.1 liters/min per m2; p less than 0.001). In patients compared with normal subjects, peak left ventricular stroke volume index (34 +/- 9 versus 46 +/- 7 ml/min per m2; p less than 0.01) and end-diastolic volume index (56 +/- 14 versus 68 +/- 12 ml/min per m2; p less than 0.08) were reduced, whereas peak ejection fraction and end-systolic volume index were not different. In patients, the change in end-diastolic volume index during exercise correlated strongly with the change in stroke volume index (r = 0.97; p less than 0.0001) and cardiac index (r = 0.80; p less than 0.03). Pulmonary wedge pressure was markedly increased at peak exercise in patients compared with normal subjects (25.7 +/- 9.1 versus 7.1 +/- 4.4 mm Hg; p less than 0.0001). Patients demonstrated a shift of the left ventricular end-diastolic pressure-volume relation upward and to the left at rest. Increases in left ventricular filling pressure during exercise were not accompanied by increases in end-diastolic volume, indicating a limitation to left ventricular filling.(ABSTRACT TRUNCATED AT 250 WORDS)

  10. Miks sponsoreerivad ettevõtted suurüritusi? / Frank Svenhard, Liivi Tadolder ; interv. Annika Rõõmus

    Index Scriptorium Estoniae

    Svenhard, Frank

    2006-01-01

    ALD Automotive Baltikumi tegevdirektor ja AS-i Liviko turundusjuht valikutest sponsoreerimisel, koostööst sponsoreeritavate organisatsioonidega, rahvusvahelise juhtimiskonverentsi EC2006 toetamisest

  11. 76 FR 19067 - Agency Information Collection Extension

    Science.gov (United States)

    2011-04-06

    ... consideration. ADDRESSES: Written comments may be sent to Mr. Ronald Klinefelter, Corporate Service Office... your comments. ] FOR FURTHER INFORMATION CONTACT: Mr. Ronald Klinefelter, Corporate Service...

  12. Deutsche Bibliotheksstatistik (DBS: Konzept, Umsetzung und Perspektiven für eine umfassende Datenbasis zum Bibliothekswesen in Deutschland: 10 Fragen von Bruno Bauer an Ronald M. Schmidt, Leiter der DBS / Deutsche Bibliotheksstatistik (DBS: Concept, implementation and prospect for a comprehensive database on library statistics in Germany: 10 questions interview with Ronald M. Schmidt, head of DBS, by Bruno Bauer

    Directory of Open Access Journals (Sweden)

    Schmidt, Ronald M.

    2008-06-01

    Full Text Available The DBS, Deutsche Bibliotheksstatistik (German Library Statistics, http://www.bibliotheksstatistik.de, reports since 1974. Around 9000 libraries file data on facilities, equipment, holdings, usage, budget and staff.Data collection, evaluation, and presentation today are carried out online only. Aim of DBS is the formation of a national data pool containing statistical data on all types of libraries.The interview informs about the concept of DBS and its differentation of public, university and specialised libraries. It covers at length the increasing important topic of data collection of holdings and usage in digital libraries. The DBS process of data evaluation and publication will be described and connections between DBS and the library benchmark index BIX will be explained. Finally international cooperation options for DBS will be discussed.

  13. Coeur d'Alene Tribal Production Facility, Volume II of III, 2002-2003 Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Anders, Paul

    2003-01-01

    This appendices covers the following reports: (1) Previous ISRP Reviews (Project 199004400) Implement Fisheries Enhancement Opportunities-Coeur d'Alene Reservation; (2) Step 1 review of the hatchery master plan (Memorandum from Mark Fritsch, Fish Production Coordinator, Draft version March 10, 2000); (3) Coeur d'Alene Tribe response to ISRP comments on Project No. 199004402; includes attachment A Water Quantity Report. This is an incomplete document Analysis of Well Yield Potential for a Portion of the Coeur d'Alene Reservation near Worley, Idaho, February 2001; (4) Coeur d'Alene Tribe Fisheries Program, Rainbow Trout Feasibility Report on the Coeur d'Alene Indian Reservation prepared by Ronald L. Peters, February 2001; (5) Coeur d'Alene Tribe response letter pursuant to the questions raised in the Step 1 review of the Coeur d'Alene Tribe Trout Production Facility from Ronald L. Peters, March 27, 2001 ; includes attachments Water quantity report (this is the complete report), Appendix A Logs for Test Wells and 1999 Worley West Park Well, letters from Ralston, Appendix B Cost of Rainbow Purchase Alternative; (6) NPPC response (memorandum from Mark Fritsch, March 28, 2001); (7) Response to NPPC (letter to Frank Cassidy, Jr., Chair, from Ernest L. Stensgar, April 18, 2001); (8) Final ISRP review (ISRP 2001-4: Mountain Columbia Final Report); (9) Response to ISRP comment (letter to Mark Walker, Director of Public Affairs, from Ronald Peters, May 7, 2001); (10) Final comments to the Fish 4 committee; (11) Scope of Work/Budget FY 2001-2004; (12) Letter from City of Worley concerning water service; (13) Letter to BPA regarding status of Step 1 package; (14) Fisheries Habitat Evaluation on Tributaries of the Coeur d'Alene Indian Reservation, 1990 annual report; (15) Fisheries Habitat Evaluation on Tributaries of the Coeur d'Alene Indian Reservation, 1991 annual report; and (16) Fisheries Habitat Evaluation on Tributaries of the

  14. Watching the detectors physics can tell us why we're here, says Frank Close, if we know how to look

    CERN Multimedia

    2002-01-01

    The authors of 'The Particle Odyssey' explain that for the first time they provide individual portraits of all the major particles discovered by experimental techniques. "It is a showcase of particle imagery, from early cloud chamber and emulsion photographs to the latest computer graphic displays. The pictures show that the subatomic world is real and accessible; and also has its own peculiar beauty" (1 page).

  15. 赖特与老子:心灵深处的共鸣%Frank Lloyd Wright and Laozi: Two Great Minds Striking One Chord

    Institute of Scientific and Technical Information of China (English)

    吴麒; 吴平祥

    2008-01-01

    美国20世纪伟大的建筑师赖特的建筑思想与中国古代老子思想有某些相似之处.赖特思想主要不是受老子思想的影响,而是与老子思想共鸣.这种共鸣可以使我们对大师级人才的成长得到许多有益的启示.

  16. Aldis, Anne C. and Roger N. McDermott, eds., Russian Military Reform, 1992-2002. Portland, OR: Frank Cass, 2003.

    Directory of Open Access Journals (Sweden)

    Christian Erickson

    2004-07-01

    Full Text Available In this edited volume, the fourth book in the Cass Series on Soviet (Russian Military Institutions, the authors analyze the security threats the first two post-Soviet administrations and military apparatus have had to contend with. The period covered by this volume is one of the most tumultuous which has confronted the Russian military. The array of new threats, resource limitations, the ambiguity of civil-military relations, and the interaction between the military, law enforcement, and int...

  17. 75 FR 64773 - Study Required by Section 989G(b) of the Dodd-Frank Act Regarding Compliance With Section 404(b...

    Science.gov (United States)

    2010-10-20

    ... Exchange Act Rule 12b-2 . \\4\\ See, e.g., Release No. 33-9072 (Oct. 13, 2009) [74 FR 53628]; and Release 33... Commission (COSO), such as the June 2006 guidance for smaller public companies on internal control over... http://www.coso.org/ICFR-GuidanceforSPCs.htm . \\9\\ For further information, see...

  18. The Difference between a Journal Article and a Complete Intellectual and Psychological Report: A Frank Account of How One Small Project Was Born, Executed, and Reported.

    Science.gov (United States)

    Holland, John L.

    1991-01-01

    Holland gives a personal account of how the preceding article was initiated and executed. Origins of the research project, the process of statistical analysis, preparation of the final article, and advice for beginning researchers are included. (SK)

  19. Cushing at Zuni: The Correspondence and Journals of Frank Hamilton Cushing, 1879-1884, edited by Jesse Green, University of New Mexico Press, Albuquerque, 1990

    Directory of Open Access Journals (Sweden)

    Jonathan E. Reyman

    1992-11-01

    Full Text Available Turn-of-the-century anthropologists were a colorful and controversial lot, some of whose exploits and antics have achieved near mythical status in the history of the discipline. Although they published enormous amounts of material, much of what is now regarded as classic work and essential reading, they also behaved in ways that make today's scholars shudder with anger or disgust and shake their heads in bewilderment. And if the best of these early field workers were geniuses, they were often flawed geniuses who behavior, at times, made it difficult, and sometimes nearly impossible, for later researchers to follow them in the field.

  20. The Politics of Genre and Medium apropos of Frank O’Hara’s “On Seeing Larry Rivers’s Washington Crossing the Delaware (1955)

    DEFF Research Database (Denmark)

    Balle, Søren Hattesen

    2006-01-01

    and O’Hara’s poem politicizes their generic difference and the difference in their choice of artistic medium, insofar as they mutually contest their own authority of representativity. The latter aspect in turn reflects back critically on the heroism and romantic glorification of official American...

  1. British researchers receive awards for Grid development: Frank Harris of Oxford University was given a CERN-UK lifetime achievement award.

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Harris has played an important role in the progress of online computing while based at CERN for the past 15 years. The awards were presented by CERN's director-general, Robert Aymar, during a meeting of GridPP, a collaboration of particle physicists and computing scientists from the UK and CERN.

  2. Summer Research Program (1992). Summer Faculty Research Program (SFRP) Reports. Volume 6. Arnold Engineering Development Center, Civil Engineering Laboratory, Frank J. Seiler Research Laboratory, Wilford Hall Medical Center

    Science.gov (United States)

    1992-12-01

    cardiopulmonary resuscitation. In Miller, J. D., Teadale, G.M., Rowan, J., Gailbraith, S.L, and Mendelow , A.D. (eds) Intracranial Pressure VI, Berlin, Springer...ICP-Fluctuations by Special Techniques of Artificial Ventilation. In Miller, J. D., Teadale, G.M., Rowan, J.O., Gailbraith, S.L., and Mendelow , A.D

  3. Una verosimilitud que mata: los relatos semiautobiográficos de Ana Frank, Judith Kerr y Elie Wiesel sobre los tiempos de Hitler en español

    OpenAIRE

    Zamuner, Amanda

    2016-01-01

    Resulta innegable que la literatura del Holocausto ha crecido y se ha multiplicado gracias en parte a la dedicada labor de los traductores, capaces de recrear en una lengua otra la obra de un autor, re-creando y re-produciendo –para lectores que no eran destinatarios directos– paisajes interiores, descripciones y reflexiones que enriquecen la experiencia humana por el gran capital simbólico que suponen. Constituyen de por sí una mediación entre la historia mundial y la nacional, como afirma G...

  4. United States Air Force Summer Research Program -- 1993. Volume 6. Arnold Engineering Development Center, Frank J. Seiler Research Laboratory, Wilford Hall Medical Center

    Science.gov (United States)

    1993-12-01

    well established technique for the growth of superconductor 1 3, semiconductor 4 ,5 , and dielectric 6 ,7 thin films. Congruent evaporation in...Student Co-Investigator: Julio L. Camacho Department of Chemistry University of Miami USAF Researchers: Lt. Col. Wayne Patterson, Ph.D. Col. John H

  5. United States Air Force Summer Research Program -- 1993. Volume 16. Arnold Engineering Development Center. Frank J. Seiler Research Laboratory. Wilford Hall Medical Center

    Science.gov (United States)

    1993-12-01

    Laboratory: AEDC/ North Jackson St. Vol-Page No: 16- 1 Tullahoma Nigh School Tullahoma, TN 37388-0000 Bowlby , Andrea Laboratory: PL/GP Mudge Way Vol-Page No...January 1982. New York: Scientific American, Inc. 2. Charles Hirsch. Numerical Computation of Internal and External Flows, Volumes 1 & 2. Chichester: John

  6. The Frank Stinchfield Award: Dislocation in revision THA: do large heads (36 and 40 mm) result in reduced dislocation rates in a randomized clinical trial?

    Science.gov (United States)

    Garbuz, Donald S; Masri, Bassam A; Duncan, Clive P; Greidanus, Nelson V; Bohm, Eric R; Petrak, Martin J; Della Valle, Craig J; Gross, Allan E

    2012-02-01

    Dislocation after revision THA is a common complication. Large heads have the potential to decrease dislocation rate, but it is unclear whether they do so in revision THA. We therefore determined whether a large femoral head (36 and 40 mm) resulted in a decreased dislocation rate compared to a standard head (32 mm). We randomized 184 patients undergoing revision THA to receive either a 32-mm head (92 patients) or 36- and 40-mm head (92 patients) and stratified patients by surgeon. The two groups had similar baseline demographics. The primary end point was dislocation. Quality-of-life (QOL) measures were WOMAC and SF-36. The mean followup for dislocation was 5 years (range, 2-7 years); the mean followup for QOL was 2.2 years (range, 1.6-4 years). In the 36- and 40-mm head group, the dislocation rate was 1.1% (one of 92) versus 8.7% (eight of 92) for the 32-mm head. There was no difference in QOL outcomes between the two groups. Our observations confirm a large femoral head (36 or 40 mm) reduces dislocation rates in patients undergoing revision THA at short-term followup. We now routinely use large heads with a highly crosslinked polyethylene acetabular liner in all revision THAs. Level I, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

  7. Placing manufacturing in context (with reference to Frank Sinatra, Joseph Schumpeter, Ernie Preeg, George Mitchell, Tom Stemberg, a feckless Congress and … Secretariat)

    OpenAIRE

    Richard W. Fisher

    2013-01-01

    Remarks before the U.S. Manufacturing Summit, Orlando, Florida, August 22, 2013 ; "The remaining obstacle to being the absolute best economy for manufacturers and other businesses, bar none, has been fiscal and regulatory policy that seems incapable of providing job-creating manufacturers and other businesses with tax, spending and regulatory incentives to take advantage of the cheap and abundant fuel the Fed has provided."

  8. DISCOURSE AND THIRD SPACE IN FRANK MCCOURT’S NOVEL "TEACHER MAN" AND TOM SCHULMAN’S PLAY "DEAD POETS SOCIETY"; A REFLECTIVE PRACTICE FOR TEACHERS

    Directory of Open Access Journals (Sweden)

    Eka Sugeng Ariadi

    2017-08-01

    Full Text Available Pahl and Rowsell (2005 elucidate that Discourse is ways of dressing, speaking and acting which delineates person’s identities in literacy practices, while a third space is as a meeting spaces between home space and school space, blend and mix space, in which lets teachers think how their students’ meaning-making are happened between school and home. This paper investigates how these theories are fruitfully presented in the character of Mr. McCourt Teacher Man and Mr. Keating Dead Poets Society. Subsequently, it is interconnected with educational theory A taxonomy for Learning, teaching, and assessing: A revision of Bloom’s taxonomy of educational objectives, as recommended by Anderson and Krathwohl (2001. The result shows that the Metacognitive Knowledge domain prominently becomes the intersection as it is emphasizing on the student’s awareness of one’s own cognition and cognitive processes, particularly contextualizing students’ knowledge and general knowledge. Mr. McCourt and Mr. Keating have succeeded in shifting frighten and strict classroom situation generated by most teachers become so challenging and much interesting by utilizing multimodal styles and skills, and piloting third space activity. Henceforth, the writer recommends teachers to maximize their own potentials characters to accommodate their students’ preferences or styles in learning the subjects. In addition, designing teaching and learning process in-between home and school is necessary to be done, in order to contextualizing and perceiving real life experiences.

  9. Subversion and equilibrium The Architectural Creation of Frank Gehry%颠覆与均衡--略论弗兰克·盖瑞的建筑创作

    Institute of Scientific and Technical Information of China (English)

    周官武

    2015-01-01

    Gehry isn't a conscious architects of deconstructionist,but there are too many similarities between his practice and architectural concepts to deconstructionist. Gehry's design strategies of "creative negation"subvert the traditional pattern of architecture, however,it avoids the game of manipulating abstruse concepts and using superficial forms.He obtains the equilibrium of the construction entity through the more complex integrity and the reconstruction of orders,which exactly expand the territory of architecture space effectively.%盖瑞不是一个自觉的解构主义者,但他的创作实践和建筑理念与解构主义有诸多相合之处。盖瑞的“创造性否定”设计策略颠覆了传统建筑图式,却避免了玄奥的概念操弄和肤浅的形式游戏,他通过更加复杂的整体性和秩序的重建获得建筑实体的均衡,并以此真正有效地拓展了建筑空间的疆域。

  10. Tres artículos de Duiker. Berlage y la Nueva Objetividad. Manifiesto de Frank Lloyd Wright. Reseña del libro

    Directory of Open Access Journals (Sweden)

    Bouwen de Van Loghem

    1995-07-01

    Full Text Available Se traducen a continuación tres artículos aparecidos en la revista 8 en Opbouw (8+0, en 1932, periodo en el que Duiker era redactor de la misma. Desde este año hasta 1935 en que prematuramente falleció, su presencia en la redacción además de imprimir un indiscutido sello personal, contribuyó decisivamente a su consolidación, tras fundarse como publicación independiente precisamente en 1932.

  11. Tres artículos de Duiker. Berlage y la Nueva Objetividad. Manifiesto de Frank Lloyd Wright. Reseña del libro

    OpenAIRE

    Bouwen de Van Loghem

    2011-01-01

    Se traducen a continuación tres artículos aparecidos en la revista 8 en Opbouw (8+0), en 1932, periodo en el que Duiker era redactor de la misma. Desde este año hasta 1935 en que prematuramente falleció, su presencia en la redacción además de imprimir un indiscutido sello personal, contribuyó decisivamente a su consolidación, tras fundarse como publicación independiente precisamente en 1932.

  12. United States Air Force Summer Research Program -- 1993 Summer Research Program Final Reports. Volume 11. Arnold Engineering Development Center, Frank J. Seiler Research Laboratory, Wilford Hall Medical Center

    Science.gov (United States)

    1993-01-01

    Direction Switching A state machine for CREQ and CACK handling was written in Altera Hard- ware Description Language ( AHDL ) (see [4]). The corresponding...34, Issue 1.32. Spectrum Signal Process- ing Inc.. Burnaby. B.C.. Canada, Nov. 1991. [4] "’MAX+plusII Text Editor & AHDL ". Altera Corporation. version 1.0

  13. Küçük Frank Yıllıkları I: Aziz Amand Yıllığı

    OpenAIRE

    GENÇ, Özlem

    2016-01-01

    Aziz Amand Yıllığı kesin olarak bilinmemekle birlikte 8.-9. yüzyıllarda, aynı adlı manastırda yazılmış bir yıllıktır. Yıllıkların tarihi araştırmalarda başvurulan kaynaklardan olmaları verdikleri bilgileri son derece önemli kılmaktadır. Bu açıdan değerlendirildiğinde Aziz Amand yıllığı dikkate değerdir. Yapılan askeri seferlerden, saldırılara, toplanan meclislerden inşa edilen yapılara, verilen cezalardan doğal afetlere kadar pek çok açıdan bilgi veren yıllık, dönemin anlaşılmasına katkı sağl...

  14. FRANX. Application for analysis and quantification of the APS fire; FRANK. Aplicacion para el analisis y cuantificacion de los APS de incendios

    Energy Technology Data Exchange (ETDEWEB)

    Snchez, A.; Osorio, F.; Ontoso, N.

    2014-07-01

    The FRANX application has been developed by EPRI within the Risk and Reliability User Group in order to facilitate the process of quantification and updating APS Fire (also covers floods and earthquakes). By applying fire scenarios are quantified in the central integrating the tasks performed during the APS fire. This paper describes the main features of the program to allow quantification of an APS Fire. (Author)

  15. LEFT-VENTRICULAR BEAT-TO-BEAT PERFORMANCE IN ATRIAL-FIBRILLATION - CONTRIBUTION OF FRANK-STARLING MECHANISM AFTER SHORT RATHER THAN LONG RR INTERVALS

    NARCIS (Netherlands)

    GOSSELINK, ATM; BLANKSMA, PK; CRIJNS, HJGM; VANGELDER, IC; DEKAM, PJ; HILLEGE, HL; NIEMEIJER, MG; LIE, KI; MEIJLER, FL

    1995-01-01

    Objectives. This study sought to evaluate control mechanisms of the varying left ventricular performance in atrial fibrillation. Background. Atrial fibrillation is characterized by a randomly irregular ventricular response, resulting in continuous variation in left ventricular beat-to-beat mechanica

  16. The Frank-Starling mechanism involves deceleration of cross-bridge kinetics and is preserved in failing human right ventricular myocardium.

    Science.gov (United States)

    Milani-Nejad, Nima; Canan, Benjamin D; Elnakish, Mohammad T; Davis, Jonathan P; Chung, Jae-Hoon; Fedorov, Vadim V; Binkley, Philip F; Higgins, Robert S D; Kilic, Ahmet; Mohler, Peter J; Janssen, Paul M L

    2015-12-15

    Cross-bridge cycling rate is an important determinant of cardiac output, and its alteration can potentially contribute to reduced output in heart failure patients. Additionally, animal studies suggest that this rate can be regulated by muscle length. The purpose of this study was to investigate cross-bridge cycling rate and its regulation by muscle length under near-physiological conditions in intact right ventricular muscles of nonfailing and failing human hearts. We acquired freshly explanted nonfailing (n = 9) and failing (n = 10) human hearts. All experiments were performed on intact right ventricular cardiac trabeculae (n = 40) at physiological temperature and near the normal heart rate range. The failing myocardium showed the typical heart failure phenotype: a negative force-frequency relationship and β-adrenergic desensitization (P 0.05), indicating that this regulatory mechanism is preserved in heart failure. Length-dependent assessment of twitch kinetics mirrored these findings; normalized dF/dt slowed down with increasing length of the muscle and was virtually identical in diseased tissue. This study shows for the first time that muscle length regulates cross-bridge kinetics in human myocardium under near-physiological conditions and that those kinetics are preserved in the right ventricular tissues of heart failure patients.

  17. Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins

    Energy Technology Data Exchange (ETDEWEB)

    Ait-Mou, Younss; Hsu, Karen; Farman, Gerrie P.; Kumar, Mohit; Greaser, Marion L.; Irving, Thomas C.; de Tombe, Pieter P. (UW); (Loyola); (IIT)

    2016-04-29

    We determined that the Frank–Starling mechanism of the heart is due, in part, to modulation of myofilament Ca2+ sensitivity by sarcomere length (SL) [length-dependent activation (LDA)]. The molecular mechanism(s) that underlie LDA are unknown. Recent evidence has implicated the giant protein titin in this cellular process, possibly by positioning the myosin head closer to actin. To clarify the role of titin strain in LDA, we isolated myocardium from either WT or homozygous mutant (HM) rats that express a giant splice isoform of titin, and subjected the muscles to stretch from 2.0 to 2.4 μm of SL. Upon stretch, HM compared with WT muscles displayed reduced passive force, twitch force, and myofilament LDA. Time-resolved small-angle X-ray diffraction measurements of WT twitching muscles during diastole revealed stretch-induced increases in the intensity of myosin (M2 and M6) and troponin (Tn3) reflections, as well as a reduction in cross-bridge radial spacing. Independent fluorescent probe analyses in relaxed permeabilized myocytes corroborated these findings. X-ray electron density reconstruction revealed increased mass/ordering in both thick and thin filaments. The SL-dependent changes in structure observed in WT myocardium were absent in HM myocardium. Our results reveal a correlation between titin strain and the Frank–Starling mechanism. The molecular basis underlying this phenomenon appears not to involve interfilament spacing or movement of myosin toward actin but, rather, sarcomere stretch-induced simultaneous structural rearrangements within both thin and thick filaments that correlate with titin strain and myofilament LDA.

  18. Left ventricular beat-to-beat performance in atrial fibrillation: Contribution of Frank-Starling mechanism after short rather than long intervals

    NARCIS (Netherlands)

    Gosselink, A.T.M.; Blanksma, P.K.; Crijns, H.J.G.M.; Gelder, I.C. van; Kam, P.J. de; Hillege, H.L.; Niemeijer, M.G.; Lie, K.I.; Meijler, F.L.

    1995-01-01

    This study sought to evaluate control mechanisms of the varying left ventricular performance in atrial fibrillation. Atrial fibrillation is characterized by a randomly irregular ventricular response, resulting in continuous variation in left ventricular beat-to-beat mechanical behavior and hemodynam

  19. Glucagon-like peptide-1 (7-36) but not (9-36) augments cardiac output during myocardial ischemia via a Frank-Starling mechanism.

    Science.gov (United States)

    Goodwill, Adam G; Tune, Johnathan D; Noblet, Jillian N; Conteh, Abass M; Sassoon, Daniel; Casalini, Eli D; Mather, Kieren J

    2014-01-01

    This study examined the cardiovascular effects of GLP-1 (7-36) or (9-36) on myocardial oxygen consumption, function and systemic hemodynamics in vivo during normal perfusion and during acute, regional myocardial ischemia. Lean Ossabaw swine received systemic infusions of saline vehicle or GLP-1 (7-36 or 9-36) at 1.5, 3.0, and 10.0 pmol/kg/min in sequence for 30 min at each dose, followed by ligation of the left circumflex artery during continued infusion at 10.0 pmol/kg/min. Systemic GLP-1 (9-36) had no effect on coronary flow, blood pressure, heart rate or indices of cardiac function before or during regional myocardial ischemia. Systemic GLP-1 (7-36) exerted no cardiometabolic or hemodynamic effects prior to ischemia. During ischemia, GLP-1 (7-36) increased cardiac output by approximately 2 L/min relative to vehicle-controls (p = 0.003). This response was not diminished by treatment with the non-depolarizing ganglionic blocker hexamethonium. Left ventricular pressure-volume loops measured during steady-state conditions with graded occlusion of the inferior vena cava to assess load-independent contractility revealed that GLP-1 (7-36) produced marked increases in end-diastolic volume (74 ± 1 to 92 ± 5 ml; p = 0.03) and volume axis intercept (8 ± 2 to 26 ± 8; p = 0.05), without any change in the slope of the end-systolic pressure-volume relationship vs. vehicle during regional ischemia. GLP-1 (9-36) produced no changes in any of these parameters compared to vehicle. These findings indicate that short-term systemic treatment with GLP-1 (7-36) but not GLP-1 (9-36) significantly augments cardiac output during regional myocardial ischemia, via increases in ventricular preload without changes in cardiac inotropy.

  20. Mechanics and energetics of overstretch: the relationship of altered left ventricular volume to the Frank-Starling mechanism and phosphorylation potential.

    Science.gov (United States)

    Abe, H; Holt, W; Watters, T A; Wu, S; Parmley, W W; Schiller, N; Higgins, C; Wikman-Coffelt, J

    1988-08-01

    Isovolumic perfused rat hearts containing an intraventricular balloon were used to assess the effects of incremental balloon volumes on developed pressure, oxygen consumption, coronary flow, phosphorylation potential obtained by P-31 nuclear magnetic resonance, wall thickness obtained by two-dimensional echocardiography, and diastolic wall stress. Three phases in developed pressure were noted: (1) volumes from 0 to 150 microliter resulted in a continuous increase in developed pressure; (2) with volumes from 150 to 250 microliter, developed pressure remained constant whereas developed (systolic) and diastolic wall stress rose sharply; and (3) with volumes from 250 to 400 microliter, developed pressure fell whereas developed (systolic) and diastolic wall stress continued to rise. The ln [(PCr)/(Pi)] was in synchrony with oxygen consumption at 0 and 50 microliter balloon volumes, and then diverged at volumes greater than 100 microliter. Oxygen consumption increased from 0 to 50 microliter, was constant from 50 to 250 microliter balloon volume, and then declined. The ln [(PCr)/(Pi)] fell precipitously at balloon volumes greater than 100 microliter, most likely limited by oxygen consumption. Coronary flow did not change significantly until 250 microliter or more of water was added to the balloon, and then it started to decline. Volumes greater than 100 microliter result in overstretch of myofibers, as observed by the precipitous decline in ln [(PCr)/(Pi)], and the steep increase in diastolic wall stress. With excessive volume loading, the drop in phosphorylation potential, ln [(PCr)/(Pi)], appears to contribute to the decrease in developed pressure.

  1. Regulation of central blood volume and cardiac filling in endurance athletes: the Frank-Starling mechanism as a determinant of orthostatic tolerance

    Science.gov (United States)

    Levine, B. D.; Blomqvist, C. G. (Principal Investigator)

    1993-01-01

    Orthostatic intolerance may result from either an abnormally large postural decrease in central blood volume, cardiac filling pressures, and stroke volume, or inadequate neurohumoral responses to orthostasis. Endurance athletes have been reported as having a high incidence of orthostatic intolerance, which has been attributed primarily to abnormalities in baroreflex regulation of heart rate and peripheral resistance. In this review, we present evidence that athletes also have structural changes in the cardiovascular system that although beneficial during exercise, lead to an excessively large decrease in stroke volume during orthostasis and contribute to orthostatic intolerance. A unifying hypothesis based on cardiac mechanics that may explain the divergence of findings in conditions such as bed rest or spaceflight, and short- and long-term endurance training is presented.

  2. Multibeam collection for deepslope2007: Multibeam data collected aboard Ronald Brown from 2007-06-04 to 2007-07-06, departing from Fort Lauderdale, FL and returning to Galveston, TX

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  3. Multibeam collection for RB0605AMMA: Multibeam data collected aboard Ronald Brown from 2006-05-27 to 2006-06-18, departing from San Juan, Puerto Rico and returning to Recife, Brazil

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  4. Multibeam collection for RB0307: Multibeam data collected aboard Ronald Brown from 2003-09-08 to 2003-10-02, departing from St. Petersburg, FL and returning to Gulfport, MS

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  5. Multibeam collection for RB0404b: Multibeam data collected aboard Ronald Brown from 2004-05-08 to 2004-05-24, departing from Woods Hole, MA and returning to Boston, MA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  6. Multibeam collection for RB10TR: Multibeam data collected aboard Ronald Brown from 2010-08-28 to 2010-08-31, departing from Charleston, SC and returning to Charleston, SC

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  7. Multibeam collection for RB0709: Multibeam data collected aboard Ronald Brown from 2007-10-09 to 2007-11-07, departing from Charleston, SC and returning to Galapagos Islands, Ecuador

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  8. Multibeam collection for RB1201: Multibeam data collected aboard Ronald Brown from 2012-02-18 to 2012-03-03, departing from Charleston, SC and returning to Charleston, SC

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  9. Multibeam collection for RB0305: Multibeam data collected aboard Ronald Brown from 2003-08-28 to 2003-09-04, departing from Unknown Port and returning to Unknown Port

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  10. Multibeam collection for RB0406: Multibeam data collected aboard Ronald Brown from 2004-06-16 to 2004-06-29, departing from Woods Hole, MA and returning to Portsmouth, NH

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  11. Multibeam collection for RB0301: Multibeam data collected aboard Ronald Brown from 2003-02-04 to 2003-02-15, departing from Charleston, SC and returning to Miami, FL

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  12. Multibeam collection for RB1008: Multibeam data collected aboard Ronald Brown from 2010-11-13 to 2010-11-22, departing from Pensacola, FL and returning to Cape Canaveral, FL

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  13. Multibeam collection for RB0204: Multibeam data collected aboard Ronald Brown from 2002-06-17 to 2002-06-29, departing from Jacksonville, FL and returning to Miami, FL

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  14. Multibeam collection for RB0601: Multibeam data collected aboard Ronald Brown from 2006-02-15 to 2006-03-05, departing from Charleston, SC and returning to Bridgetown, Barbados

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  15. Multibeam collection for RB05patch: Multibeam data collected aboard Ronald Brown from 2005-07-11 to 2005-07-15, departing from Charleston, SC and returning to Woods Hole, MA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  16. Multibeam collection for RB0706: Multibeam data collected aboard Ronald Brown from 2007-08-08 to 2007-08-23, departing from Boston, MA and returning to Buzzards Bay, MA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  17. Multibeam collection for RB1202: Multibeam data collected aboard Ronald Brown from 2012-07-02 to 2012-07-17, departing from Charleston, SC and returning to Miami, FL

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  18. Multibeam collection for RB09TR: Multibeam data collected aboard Ronald Brown from 2009-01-15 to 2009-04-15, departing from Rodman, Panama and returning to Charleston, SC

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  19. Multibeam collection for RB0702: Multibeam data collected aboard Ronald Brown from 2007-04-14 to 2007-04-29, departing from San Juan, Puerto Rico and returning to Bridgetown, Barbados

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  20. Multibeam collection for RB0707: Multibeam data collected aboard Ronald Brown from 2007-08-26 to 2007-09-05, departing from Buzzards Bay, MA and returning to Charleston, SC

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...