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Sample records for francisco novos alvos

  1. New molecular targets for PET and SPECT imaging in neurodegenerative diseases Novos alvos moleculares para tomografia por emissão de pósitrons (PET e tomografia computadorizada por emissão de fóton único (SPECT em doenças neurodegenerativas

    Directory of Open Access Journals (Sweden)

    Marcel Benadiba

    2012-10-01

    Full Text Available The pathophysiology of neurodegenerative diseases (ND such as Alzheimer's disease (AD and Parkinson's disease (PD has not yet been completely elucidated. However, in the past few years, there have been great knowledge advances about intra-and extracellular proteins that may display impaired function or expression in AD, PD and other ND, such as amyloid beta (Aβ, α-synuclein, tau protein and neuroinflammatory markers. Recent developments in the imaging techniques of positron emission tomography (PET and single photon emission computed tomography (SPECT now allow the non-invasive tracking of such molecular targets of known relevance to ND in vivo. This article summarizes recent findings of PET and SPECT studies using these novel methods, and discusses their potential role in the field of drug development for ND as well as future clinical applications in regard to differential diagnosis of ND and monitoring of disease progression.A fisiopatologia das doenças neurodegenerativas (DN, tais como a doença de Alzheimer (DA e a doença de Parkinson (DP, ainda não é completamente compreendida. No entanto, nos últimos anos, houve grandes avanços em termos do conhecimento sobre proteínas intra e extracelulares, tais como beta-amiloide (Aβ, α-sinucleína, proteína tau e marcadores neuroinflamatórios, que podem ter sua função ou expressão prejudicada na DA, DP ou em outras DN. Progressos recentes nas técnicas de tomografia por emissão de pósitrons (PET e tomografia computadorizada por emissão de fóton único (SPECT permitem hoje em dia a identificação não invasiva de tais alvos moleculares in vivo. Este artigo resume descobertas recentes de estudos de PET e SPECT cerebral usando esses alvos moleculares inovadores e discute o papel potencial dessas técnicas no campo do desenvolvimento de novos medicamentos para as DN, bem como futuras aplicações clínicas em relação ao diagnóstico diferencial e monitoramento da progressão dessas

  2. Plaquetas: ainda um alvo terapêutico Platelets: still a therapeutical target

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    Helena Carla Castro

    2006-10-01

    Full Text Available As plaquetas são fragmentos citoplasmáticos anucleados presentes no sangue e produzidos na medula óssea a partir dos megacariócitos. O objetivo deste trabalho é rever as bases mecanísticas e moleculares das plaquetas, revelando sua participação em síndromes importantes e na trombose arterial, além de seu potencial como alvo terapêutico para o desenho de novos agentes antitrombóticos.Platelets are cytoplasmatic fragments from bone marrow megakaryocytes present on blood. The aim of this work is to review the basis of platelet mechanisms, their participation in syndromes and in arterial thrombosis, and its potential as a target for design of antithrombotic agents.

  3. Kunstjäsemetega inimsööjad / Mart Kalvet, Alvo Aabloo, Kristjan Port

    Index Scriptorium Estoniae

    Kalvet, Mart, 1975-

    2011-01-01

    Inimene, meditsiin ja biotehnoloogia aastal 2031. Ennustavad tõlkija Mart Kalvet, Tartu Ülikooli arukate materjalide ja süsteemide labori professor Alvo Aabloo ja Tallinna Ülikooli Terviseteaduste ja Spordi Instituudi direktor Kristjan Port

  4. 3.3 Ga SHRIMP U-Pb zircon age of a felsic metavolcanic rock from the Mundo Novo greenstone belt in the São Francisco craton, Bahia (NE Brazil)

    Science.gov (United States)

    Peucat, J. J.; Mascarenhas, J. F.; Barbosa, J. S. F.; de Souza, S. L.; Marinho, M. M.; Fanning, C. M.; Leite, C. M. M.

    2002-07-01

    Felsic metavolcanics associated with supracrustal rocks provide U-Pb zircon and Sm-Nd TDM ages of approximately 3.3 Ga, which establish an Archean age of the Mundo Novo greenstone belt. A granodioritic gneiss from the Mairi complex, located on the eastern boundary of the Mundo Novo greenstone belt, exhibits a zircon evaporation minimum age of 3.04 Ga and a Nd model age of 3.2 Ga. These results constrain the occurrence of at least three major geological units in this area: the Archean Mundo Novo greenstone belt, the Archean Mairi gneisses, and the adjoining Paleoproterozoic (<2.1 Ga) Jacobina sedimentary basin. The Jacobina basin follows the same trend as the Archean structure, extending southward to the Contendas-Mirante belt, in which a similar Archean-Paleoproterozoic association appears. We postulate that during the Paleoproterozoic in the eastern margin of the Gavião block, these Archean greenstone belts constituted a zone of weakness along which a late-stage orogenic sedimentary basin developed.

  5. Reassessment of the geologic evolution of selected precambrian terranes in Brazil, based on SHRIMP U-Pb data, part 2: mineiro and Aracuai orogens and Southern Sao Francisco craton; Reavaliacao da evolucao geologica em terrenos pre-cambrianos brasileiros com base em novos dados U-Pb SHRIMP, parte 2: orogeno Aracuai, cinturao mineiro e craton Sao Francisco Meridional

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Luiz Carlos da; Pimentel, Marcio [Brasilia Univ., DF (Brazil). Inst. de Geociencias]. E-mail: luizcarlos@aneel.gov.br; Leite, Carlos Augusto; Vieira, Valter Salino; Silva, Marcio Antonio da; Paes, Vinicius Jose de Castro; Cardoso Filho, Joao Moraes [Companhia de Pesquisas de Recursos Minerais (CPRM), Belo Horizonte, MG (Brazil); Armstrong, Richard [Australian National Univ., Canberra (Australia). Research School of Earth Sciences; Noce, Carlos Mauricio; Pedrosa-Soares, Antonio Carlos [Minas Gerais Univ., Belo Horizonte (Brazil). Inst. de Geociencias. Centro de Pesquisa Manuel Teixeira da Costa; Carneiro, Mauricio Antonio [Ouro Preto Univ., MG (Brazil). Dept. de Geologia

    2002-12-15

    This paper discusses new zircon SHRIMP (Sensitive High Resolution Ion Microprobe) U-Pb geochronological data for 19 key-exposures of several geological units exposed at the eastern border of the Southern Sao Francisco Craton and at the adjacent Proterozoic Mineiro and Aracuai orogens. Samples were collected along several E-W tran sects, aiming at tracing the precise limit of the Sao Francisco Craton Archean basement, as well as assessing the extension of the successive proterozoic orogenic collages. Due to the complex geologic history and/or high grade metamorphism which most of the rock units investigated have undergone, zircon morphology and the U-Pb analytical data exhibit very complex patterns. These are characterized by a combination of inheritance, partial resetting and new zircon growth during high-grade metamorphism. As a consequence, very careful and detailed analyses of cathodoluminescence imagery were required to allow distinction between inheritance, newly melt-precipitated zircon and partially reset zircons, as well as between the ages of magmatic and metamorphic events. In the southeastern border of the craton 5 units yielded Archean crystallization ages ranging from ca. 3000-2700 Ma, with poorly constrained metamorphic ages ranging from ca. 2850 to 550 Ma. The TTG gneissic complex exposed to the east and south of the Quadrilatero Ferrifero, formerly ascribed to the Archean basement, have crystallization ages from ca. 2210 Ma to 2050 Ma, and can now be interpreted as representing pre- to syn-collisional magmatic phases of the Mineiro Belt. Metamorphic ages of ca. 2100 Ma and 560 Ma are also well constrained in zircon populations from these gneisses. The crystallization age of ca 1740 Ma observed for an alkaline granite of the Borrachudos Suite (intrusive into the Archean basement east of the Southern Espinhaco Range) confirmed previous conventional U-Pb data for this Paleoproterozoic rift-related magmatism. One of the major basement inliers within the

  6. San Francisco Accelerator Conference

    International Nuclear Information System (INIS)

    Southworth, Brian

    1991-01-01

    'Where are today's challenges in accelerator physics?' was the theme of the open session at the San Francisco meeting, the largest ever gathering of accelerator physicists and engineers

  7. A BACE I como alvo terapêutico na Doença de Alzheimer

    OpenAIRE

    Silva, Ana Sofia Alberto e

    2016-01-01

    Monografia realizada no âmbito da unidade Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra A presente monografia tem como tema: “A BACE1 como alvo terapêutico na Doença de Alzheimer”. Atualmente, a Doença de Alzheimer (DA) é uma das doenças mais estudadas na área das neurociências e que maiores preocupações tem levantado, quer na comunidade científica, quer na sociedade em geral. A DA é uma doença ne...

  8. Fusões e aquisições : influências da competição na avaliação da empresa alvo

    OpenAIRE

    Anselmo Filho, Fernando Antonio Fernandes

    2016-01-01

    Este trabalho analisou os fatores que importam na estimação do prêmio ofertado à empresa alvo. Ao mesmo tempo que analisou a competição no mercado corporativo, entendido como um fator exógeno à empresa alvo, avaliou condições internas à empresa alvo, como por exemplo seu endividamento, entendido como fator endógeno. A literatura sobre aquisição hostil tem substancialmente avançado, mas ainda existe interesse crescente em pesquisar o processo de aquisição hostil do lance inicial até o resultad...

  9. Uso de Diferentes Sensores de Satélite na Discriminação de Alvos Naturais

    Directory of Open Access Journals (Sweden)

    Gustavo Ferreira de Souza

    2016-01-01

    Full Text Available As particularidades nos instrumentos de sensoriamento remoto, mesmo quando possuem características semelhantes, torna as imagens geradas por estes, diferentes entre si. Visando isto, o objetivo do trabalho foi analisar a aplicabilidade e os limites de detecção na identificação de alvos naturais em diferentes imagens de satélites. A área de estudo está localizada no Estado de São Paulo dentro do Município de Onda Verde, os alvos naturais foram selecionados a partir de análises realizadas nas imagens e visita desses pontos em campo. Foram escolhidas áreas que apresentaram bom contraste com o entorno e fácil localização nas imagens de satélite. Para o processamento digital de imagem foi utilizado o software livre gvSIG. Neste estudo foram empregados dados de satélites de média resolução espacial como Landsat-5, CBERS-2B e IRS-P6, disponíveis na base de dados de domínio público do INPE (Instituto Nacional de Pesquisas Espaciais e imagens de alta resolução espacial dos satélites RapidEye e WorldView-2. Nos sensores de média resolução espacial, as menores resoluções espaciais dos sensores TM e LISS-3, não impediram a visualização dos alvos espectrais analisados, visto que, no CCD que possui uma maior resolução espacial, não foi possível a identificação dos alvos escolhidos. As imagens de alta resolução espacial RapidEye e WorldView apresentaram grande riqueza de detalhamento para a cobertura do solo, a isto atrela-se a alta resolução radiométrica desses satélites.

  10. OS LGBT E O PONTIFICADO DE FRANCISCO

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    Luis Corrêa Lima

    2016-01-01

    Full Text Available Resumo: A visibilização da população LGBT e sua luta por cidadania traz grandes desafios à teologia e à pastoral. As características desta população e os problemas que a afligem interpelam a reflexão e a solidariedade. A conquista de seus novos direitos na sociedade se dá também com a colaboração de muitos cristãos, nem sempre com o apoio de suas igrejas. No ensinamento da Igreja Católica, há aberturas e resistências tanto em nível universal quanto nas conferências episcopais. A renovação no pontificado de Francisco se faz com abertura pastoral, novos enfoques doutrinais, gestos ousados e o desencadeamento de novos processos, como a preparação e a realização do Sínodo dos Bispos sobre a família, e a exortação aos teólogos a se lançarem nas questões de fronteira e assumirem os conflitos que afetam a todos. Isto incide na relação com os LGBT, impulsionando a novas interpretações da Bíblia, da lei natural e dos estudos de gênero. Abstract: The growing visibility of LGBT people and their struggle for citizenship is bringing great challenges to theology and pastoral action. The characteristics of this population and their problems call for reflection and solidarity. The conquest of their new rights in society has the collaboration of many Christians, but not always with the support of their churches. In the teaching of the Catholic Church, there are openings and resistance both at the universal level and in the episcopal conferences. The renewal in Pope Francis’ pontificate is producing pastoral initiatives, new doctrinal approaches, bold gestures, and triggering new processes, such as the preparation and implementation of the Synod of Bishops on the family, and the exhortation to theologians to deal with borderline issues and treat the conflicts that affect everyone. This has an impact on the relationship with the LGBT community, leading to new interpretations of the Bible, natural law, and gender studies.

  11. San Francisco Bay Water Quality Improvement Fund

    Science.gov (United States)

    EPAs grant program to protect and restore San Francisco Bay. The San Francisco Bay Water Quality Improvement Fund (SFBWQIF) has invested in 58 projects along with 70 partners contributing to restore wetlands, water quality, and reduce polluted runoff.,

  12. Anestesia venosa total em regime de infusão alvo-controlada: uma análise evolutiva

    OpenAIRE

    Nora,Fernando Squeff

    2008-01-01

    JUSTIFICATIVA E OBJETIVOS: A anestesia venosa total (AVT) sofreu diversos avanços desde o início da utilização da técnica. Desde a síntese dos primeiros anestésicos venosos, com a introdução dos barbitúricos (1921) e do tiopental (1934), a AVT evoluiu até o desenvolvimento da AVT com auxílio de bombas com infusão alvo-controlada (IAC). O primeiro modelo farmacocinético para uso em IAC foi descrito por Schwilden em 1981. Foi demonstrado, a partir daí, que era possível manter a concentração pla...

  13. ASTER Flyby of San Francisco

    Science.gov (United States)

    2002-01-01

    The Advanced Spaceborne Thermal Emission and Reflection radiometer, ASTER, is an international project: the instrument was supplied by Japan's Ministry of International Trade and Industry. A joint US/Japan science team developed algorithms for science data products, and is validating instrument performance. With its 14 spectral bands, extremely high spatial resolution, and 15 meter along-track stereo capability, ASTER is the zoom lens of the Terra satellite. The primary mission goals are to characterize the Earth's surface; and to monitor dynamic events and processes that influence habitability at human scales. ASTER's monitoring and mapping capabilities are illustrated by this series of images of the San Francisco area. The visible and near infrared image reveals suspended sediment in the bays, vegetation health, and details of the urban environment. Flying over San Francisco (3.2MB) (high-res (18.3MB)), we see the downtown, and shadows of the large buildings. Past the Golden Gate Bridge and Alcatraz Island, we cross San Pablo Bay and enter Suisun Bay. Turning south, we fly over the Berkeley and Oakland Hills. Large salt evaporation ponds come into view at the south end of San Francisco Bay. We turn northward, and approach San Francisco Airport. Rather than landing and ending our flight, we see this is as only the beginning of a 6 year mission to better understand the habitability of the world on which we live. For more information: ASTER images through Visible Earth ASTER Web Site Image courtesy of MITI, ERSDAC, JAROS, and the U.S./Japan ASTER Science Team

  14. 75 FR 27432 - Security Zone; Golden Guardian 2010 Regional Exercise; San Francisco Bay, San Francisco, CA

    Science.gov (United States)

    2010-05-17

    ...-AA87 Security Zone; Golden Guardian 2010 Regional Exercise; San Francisco Bay, San Francisco, CA AGENCY... security zones on the navigable waters of the San Francisco Bay in support of Golden Guardian 2010 Regional... the Coast Guard enforce temporary security zones for operations on May 18, 2010 at the Golden Guardian...

  15. Taevasse kosmoseliftiga / Alvo Aabloo

    Index Scriptorium Estoniae

    Aabloo, Alvo, 1965-

    2007-01-01

    MTÜ Spaceward Foundation on algatanud projekti Elevator 2010. Tegemist on viieaastase võistlusega, mille käigus loodetakse välja arendada peamised tehnoloogiad, mis on vajalikud kosmoselifti ehitamiseks

  16. Francisco Toledo, artista de tierra

    Directory of Open Access Journals (Sweden)

    Alejandra Ortiz Castañares

    2016-12-01

    Full Text Available The peculiarity of the art of Francisco Toledo (1940 - considered one of the greatest living Mexican artists - has consisted, since its origin, on the recover of the prehispanic culture as an aesthetic and ethical resource, in dialogue with international contemporary culture. A dialectic that is analysed throughout this text, including particularly problematic aspects of his biography, beginning from his identification with the pre Hispanic culture. It is therefore a bird's eye study, which selects certain founding characteristics of the artist and his work.

  17. Determinação do Preço de Venda Custeio Tradicional X Custeio Alvo

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    Fabio Henrique Pereira

    2003-03-01

    Full Text Available Nesta nova economia em que vivemos o conhecimento profundo sobre o cálculo dos custos e principalmente da formação do preço de venda dos produtos ou serviços é de vital importância à sobrevivência da empresa. Em virtude de tal importância é que este artigo faz uma análise comparativa entre dois sistemas de custeio utilizados para a formação do preço de venda. Um chamado de custeio tradicional onde o foco principal para a formação do preço de venda é a cobertura dos custos operacionais e da margem de lucro pretendida pela empresa. O outro sistema de custeio é mais recente e conhecido como custeio alvo ou custeio por metas ou ainda Target Costing, onde este ao contrário do custeio tradicional tem seu foco voltado para o cliente, ou seja, quem estabelece o preço de venda dos produtos ou serviços a serem comercializados é o mercado consumidor, pois a partir do preço de venda previamente estipulado é que a empresa vai determinar qual será o seu custo operacional e a margem de lucro a ser fixada. Porém, estes dois tipos de sistema de custeio para serem implantados com eficiência depende muito do tipo de negócio, do perfil adnlinistrativo e principalmente do plano estratégico adotado por cada empresa.

  18. Jack London and the San Francisco earthquake

    Science.gov (United States)

    Sachs, J.S.

    1982-01-01

    After it was over, it seemed to many, and especially to eyewitnesses like Jack London, that the earthquake and fire had devastated San Francisco. However people were confident that, like the phoeniz, San Francisco would rise from the ashes and regain her palce as the "Imperial City of the West." 

  19. Entrevista con Francisco J. Igualada

    OpenAIRE

    Puig, Carlos; Varela, Alberto; Pérez Casas, Marc

    2009-01-01

    Francisco José Igualada Delgado obtuvo, en 1981, la licenciatura en Geología de la Universidad de Barcelona. Trabajó en Dames & Moore Ingenieros en Teruel y Madrid, y en 1983 se incorporó al South African Department of Economic Affairs (Servicios Geológicos de Sudáfrica) en Mafeking, en proyectos de geotecnia, geofísica y minería; posteriormente, en España trabajo por un corto tiempo en el ITGME. En 1986 cursó un diploma de posgrado-máster en Ingeniería Geológica y Teledetección, en el ITC, U...

  20. 76 FR 22809 - Safety Zone; Bay Ferry II Maritime Security Exercise; San Francisco Bay, San Francisco, CA

    Science.gov (United States)

    2011-04-25

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2011-0196] RIN 1625-AA00 Safety Zone; Bay Ferry II Maritime Security Exercise; San Francisco Bay, San Francisco, CA AGENCY... Security Exercise; San Francisco Bay, San Francisco, CA. (a) Location. The limits of this safety zone...

  1. April 1906 San Francisco, USA Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1906 San Francisco earthquake was the largest event (magnitude 8.3) to occur in the conterminous United States in the 20th Century. Recent estimates indicate...

  2. San Francisco Bay Interferometric Bathymetry: Area B

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — High resolution sonar data were collected over ultra-shallow areas of the San Francisco Bay estuary system. Bathymetric and acoustic backscatter data were collected...

  3. De Novo Glutamine Synthesis

    Science.gov (United States)

    He, Qiao; Shi, Xinchong; Zhang, Linqi; Yi, Chang; Zhang, Xuezhen

    2016-01-01

    Purpose: The aim of this study was to investigate the role of de novo glutamine (Gln) synthesis in the proliferation of C6 glioma cells and its detection with 13N-ammonia. Methods: Chronic Gln-deprived C6 glioma (0.06C6) cells were established. The proliferation rates of C6 and 0.06C6 cells were measured under the conditions of Gln deprivation along with or without the addition of ammonia or glutamine synthetase (GS) inhibitor. 13N-ammonia uptake was assessed in C6 cells by gamma counting and in rats with C6 and 0.06C6 xenografts by micro–positron emission tomography (PET) scanning. The expression of GS in C6 cells and xenografts was assessed by Western blotting and immunohistochemistry, respectively. Results: The Gln-deprived C6 cells showed decreased proliferation ability but had a significant increase in GS expression. Furthermore, we found that low concentration of ammonia was sufficient to maintain the proliferation of Gln-deprived C6 cells, and 13N-ammonia uptake in C6 cells showed Gln-dependent decrease, whereas inhibition of GS markedly reduced the proliferation of C6 cells as well as the uptake of 13N-ammoina. Additionally, microPET/computed tomography exhibited that subcutaneous 0.06C6 xenografts had higher 13N-ammonia uptake and GS expression in contrast to C6 xenografts. Conclusion: De novo Gln synthesis through ammonia–glutamate reaction plays an important role in the proliferation of C6 cells. 13N-ammonia can be a potential metabolic PET tracer for Gln-dependent tumors. PMID:27118759

  4. 77 FR 57494 - Safety Zone; Fleet Week Fireworks, San Francisco Bay, San Francisco, CA

    Science.gov (United States)

    2012-09-18

    ... Zone; Fleet Week Fireworks, San Francisco Bay, San Francisco, CA AGENCY: Coast Guard, DHS. ACTION: Notice of enforcement of regulation. SUMMARY: The Coast Guard will enforce the safety zone for the Fleet...[deg]23'27'' W (NAD83) for the Fleet Week Fireworks in 33 CFR 165.1191, Table 1, item number 25. This...

  5. 77 FR 70891 - Safety Zone; Bay Bridge Construction, San Francisco Bay, San Francisco, CA

    Science.gov (United States)

    2012-11-28

    ...-AA00 Safety Zone; Bay Bridge Construction, San Francisco Bay, San Francisco, CA AGENCY: Coast Guard... construction of the Bay Bridge, the safety zone is necessary to provide for the safety of mariners transiting... zones (33 U.S.C. 1221 et seq.). CALTRANS will sponsor the Bay Bridge Construction Safety Zone on...

  6. 78 FR 34123 - Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA

    Science.gov (United States)

    2013-06-06

    ... completion of an inventory of human remains and associated funerary objects under the control of the San....R50000] Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA... NAGPRA Program has completed an inventory of human remains and associated funerary objects, in...

  7. 78 FR 21403 - Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA

    Science.gov (United States)

    2013-04-10

    ... completion of an inventory of human remains and associated funerary objects under the control of the San....R50000] Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA... NAGPRA Program has completed an inventory of human remains and associated funerary objects, in...

  8. Francisco Miranda, Director de Colciencias.

    Directory of Open Access Journals (Sweden)

    Efraím Otero Ruiz

    2006-09-01

    De su desempeño en Sussex (universidad distinguida mundialmente por sus estudios sobre desarrollo tecnológico, transferencia de tecnología y administración de proyectos se recibieron siempre los mejores informes, que lo colocaron en el alto nivel de los latinoamericanos ilustres que han pasado larga o brevemente por dicho claustro, como Máximo Halty-Carrere del Uruguay, Francisco Sagasti del Perú o Fernando Chaparro de Colombia. Con ese bagaje regresó al país donde fue designado como Director Administrativo del Centro Internacional de Entrenamiento e Investigación Médica (CIDEIM de Cali, cargo que ocupó de 1992 a 2002; y al terminar ese decenio fue nombrado por la Junta Directiva como Director Ejecutivo, cargo que ocupó hasta su designación en COLCIENCIAS. En Cali ha ocupado también distinguidas posiciones, tales como Miembro del Consejo Directivo de la Fundación Planeta Valle y del Consejo de Internacionalización de la Universidad Javeriana en esa ciudad...

  9. Caracterização das rochas hospedeiras e da mineralização sulfetada do Alvo Estrela (Cu-Au), Serra dos Carajás, Pará

    OpenAIRE

    Fleck, André

    2005-01-01

    André Fleck As rochas hospedeiras do Alvo Estrela (Cu-Au), na região da Serra dos Carajás, são andesitos e gabros calcioalcalinos e cogenéticos pertencentes ao Grupo Grão Pará, do Supergrupo Itacaiúnas, formados há 2,7 Ga. As rochas do alvo correspondem a uma seqüência de 400-600m de espessura de andesitos e gabros alterados compostos de hastingsita, Fepargasita, Fe-hornblenda, oligoclásio-andesina, albita, magnetita, biotitas, dravita e schorlita, com menores quantidades de chamosita. Textur...

  10. Mobile Media at San Francisco Medical Center.

    Science.gov (United States)

    Banks, Thomas L.

    1968-01-01

    In 1966 the University of California Medical Center at San Francisco (including Schools of Dentistry, Medicine, Nursing, and Pharmacy) established a broadly based communications media center designed to serve the variety of teaching, research, and continuing education requirements of the faculty. This article dwells on the variety of applications…

  11. Two paintings by Francisco Bayeu in Vergara

    Directory of Open Access Journals (Sweden)

    José Ignacio Calvo Ruata

    2017-08-01

    Full Text Available Two unpublished paintings by Francisco Bayeu are presented, located in the church of Saint Marina in Oxirondo (Vergara, Guipúzcoa. Both are dedicated to Saint Roch and Saint Sebastian, as they are two versions of the same subject because the work had to be repeated.

  12. San Francisco, California: Solar in Action (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2011-10-01

    This brochure provides an overview of the challenges and successes of San Francisco, CA, a 2007 Solar America City awardee, on the path toward becoming a solar-powered community. Accomplishments, case studies, key lessons learned, and local resource information are given.

  13. Desenvolvimento de novos produtos através do gerenciamento simultâneo de projetos (GSP) : um estudo de caso na indústria de máquinas agrícolas

    OpenAIRE

    Roberto Dall'Agnol

    2001-01-01

    Esta pesquisa foi realizada com o objetivo de otimizar as atividades de gerenciamento no desenvolvimento de novos produtos na AGCO, empresa fabricante de máquinas agrícolas, e em sua cadeia de fornecedores. A engenharia simultânea ou, mais amplamente, o gerenciamento simultâneo de projetos é um sistema para administração de projetos que permite encurtar o tempo de lançamento de um produto e, ao mesmo tempo, reduzir os gastos no projeto, atendendo às necessidades dos clientes-alvo. Pesquisador...

  14. Statistical treatment of geochemical data and its application in the geologic mapping and in the definition of the geochemical anomalies in the Alvo 2-Corpo 4 -Provincia Mineral de Carajas

    International Nuclear Information System (INIS)

    Moura, C.A.V.

    1982-01-01

    It was given a statistical treatment for the geochemical data about soil in the are named Alvo2 - Corpo4- in the Provincia Mineral de Carajas, Para, Brazil, for application of the geological mapping and definition of geochemical anomalies. (A.B.) [pt

  15. Communication and Community in a City Under Siege: The AIDS Epidemic in San Francisco.

    Science.gov (United States)

    Rogers, Everett M.; And Others

    1995-01-01

    Discusses communication and social construction, AIDS and San Francisco, San Francisco's gay community, and the social construction of AIDS in San Francisco. Describes three eras of HIV-AIDS prevention in San Francisco, a particular HIV prevention program, and the impact of the epidemic in San Francisco. (SR)

  16. Agriculture, Rio Sao Francisco, Brazil, South America

    Science.gov (United States)

    1988-01-01

    The large field patterns in this view of the Rio Sao Francisco basin, Brazil, South America, (11.5S, 43.5W) indicate a commercial agriculture venture; family subsistence farms are much smaller and laid out in different patterns. Land clearing in Brazil has increased at an alarming rate in recent years and preliminary estimates suggest a 25 to 30% increase in deforestation since 1984. The long term impact on the ecological processes are still unknown.

  17. An overview of San Francisco Bay PORTS

    Science.gov (United States)

    Cheng, Ralph T.; McKinnie, David; English, Chad; Smith, Richard E.

    1998-01-01

    The Physical Oceanographic Real-Time System (PORTS) provides observations of tides, tidal currents, and meteorological conditions in real-time. The San Francisco Bay PORTS (SFPORTS) is a decision support system to facilitate safe and efficient maritime commerce. In addition to real-time observations, SFPORTS includes a nowcast numerical model forming a San Francisco Bay marine nowcast system. SFPORTS data and nowcast numerical model results are made available to users through the World Wide Web (WWW). A brief overview of SFPORTS is presented, from the data flow originated at instrument sensors to final results delivered to end users on the WWW. A user-friendly interface for SFPORTS has been designed and implemented. Appropriate field data analysis, nowcast procedures, design and generation of graphics for WWW display of field data and nowcast results are presented and discussed. Furthermore, SFPORTS is designed to support hazardous materials spill prevention and response, and to serve as resources to scientists studying the health of San Francisco Bay ecosystem. The success (or failure) of the SFPORTS to serve the intended user community is determined by the effectiveness of the user interface.

  18. ONU: velhos problemas novos desafios

    Directory of Open Access Journals (Sweden)

    KARIN COSTA VASQUEZ

    2010-12-01

    Full Text Available A grande quantidade de crises enfrenta pela Organização das Nações Unidas recentemente contribuiu enormente para o aumento da desilusão com relação à essa instituição. Nesse sentido o presente artigo busca oferecer um panorama da ONU,tendo como focos os antigos problemas a serem enfrentados e os novos constrangimentos que ela deverá enfrentar.

  19. Recentes avanços da quimioterapia das leishmanioses: moléculas intracelulares como alvo de fármacos Recent advances on leishmaniasis chemotherapy: intracelular molecules as a drug target

    Directory of Open Access Journals (Sweden)

    Rômulo José Soares-Bezerra

    2004-06-01

    Full Text Available Leishmanioses são doenças causadas por protozoários do gênero Leishmania sp., que se apresentam na forma promastigota ou amastigota; os promastigotas infectam o inseto vetor e os amastigotas são as formas infectivas antes presentes em macrófagos humanos. O tratamento utilizado pela clínica tem se mostrado ineficaz; os fármacos utilizados se apresentam na forma injetável, o que dificulta o tratamento, já que o paciente, para ser tratado, deve ser internado para as aplicações - que são dolorosas - e assim muitos pacientes desistem do tratamento. Outra razão para a internação é a monitoração dos efeitos colaterais causados pelos fármacos. Por estas razões a quimioterapia para leishmaniose tem sido objeto de estudo de muitos laboratórios de pesquisa, os quais têm testado outras substâncias químicas e extratos de plantas com a finalidade de se encontrar novos agentes leishmanicidas com menores efeitos colaterais e ótima biodisponibilidade. Além disso, pesquisam-se, também, outras formas farmacêuticas que viabilizem a aplicação desses fármacos, o que tornaria desnecessária a internação do paciente para se efetuar o tratamento. Este artigo visa discutir os recentes avanços da quimioterapia utilizada para as leishmanioses e, também, apresentar os aspectos farmacológicos e bioquímicos da participação de moléculas intracelulares do parasita como alvos de fármacos.The leishmaniases are diseases caused by protozoan parasites Leishmania sp., that are present in promastigotes or amastigotes forms; the promastigotes infect the sand fly vector, and the amastigotes are the infective forms presented on human macrophages. These protozooses showed two types of clinical manifestations: tegumentar and visceral. The clinical treatments used have shown inefficient; the drugs utilized are presented in injectable form, difficulting the treatment, since to be the patient, may be interned for applications, which are painful

  20. 77 FR 45594 - San Francisco Public Utilities Commission; Notice of Application Accepted for Filing and...

    Science.gov (United States)

    2012-08-01

    ...-000] San Francisco Public Utilities Commission; Notice of Application Accepted for Filing and... the San Francisco Public Utilities Commission's Water Supply and Treatment Divisions transmission... Public Utilities Commission, Power Enterprise Division, 1155 Market Street, 4th Floor, San Francisco...

  1. Plantas transgênicas resistentes a insetos e organismos não-alvo: predadores, parasitóides e polinizadores - doi: 10.5102/ucs.v4i1.23

    Directory of Open Access Journals (Sweden)

    Marina Regina Frizzas

    2008-04-01

    Full Text Available Plantas geneticamente modificadas resistentes aos insetos oferecem benefícios à agricultura moderna. No entanto, esta tecnologia pode afetar o controle biológico natural e a biodiversidade por meio de efeitos diretos e indiretos das plantas transgênicas sobre o valor adaptativo e comportamental de predadores, parasitóides, polinizadores e outros artrópodes não-alvo. Neste artigo, são discutidos os impactos ou os efeitos potenciais de plantas transgênicas resistentes a insetos sobre organismos não-alvo, com ênfase em artrópodes predadores, parasitóides e polinizadores, e os principais estudos com plantas transgênicas resistentes a insetos, publicados nos últimos dez anos.

  2. A Public Trial De Novo

    DEFF Research Database (Denmark)

    Vedel, Jane Bjørn; Gad, Christopher

    2011-01-01

    This article addresses the concept of “industrial interests” and examines its role in a topical controversy about a large research grant from a private foundation, the Novo Nordisk Foundation, to the University of Copenhagen. The authors suggest that the debate took the form of a “public trial......” where the grant and close(r) intermingling between industry and public research was prosecuted and defended. First, the authors address how the grant was framed in the media. Second, they redescribe the case by introducing new “evidence” that, because of this framing, did not reach “the court...

  3. Trabalho docente com alunos público-alvo da educação especial na educação infantil

    Directory of Open Access Journals (Sweden)

    Jaqueline Belga Marques

    2016-09-01

    Full Text Available O presente artigo teve por objetivo analisar o trabalho docente, na Educação Infantil, com alunos Público-Alvo da Educação Especial (PAEE, em sala de aula comum, particularmente no que se refere a alunos com transtorno do espectro autista. Para tal, foi realizada uma pesquisa de abordagem qualitativa com a participação de uma docente da Educação Infantil, que atua em uma escola da rede municipal, de uma cidade do interior do estado de São Paulo. Para alcançar o objetivo proposto, a professora participou de uma entrevista semiestruturada. Como resultado, constatou-se, quanto à inclusão de aluno com transtorno do espectro autista, barreiras atitudinais e confusões conceituais sobre o perfil desse público. Foi verificada a necessidade de adoção de práticas colaborativas que envolvam não apenas o professor generalista, que atua na sala regular, e o especialista, responsável pela oferta de Atendimento Educacional Especializado (AEE, na sala de recursos multifuncionais, mas também a escola, como um todo, a família e demais profissionais envolvidos. É premente a necessidade de discussão acerca do descompasso entre o discurso e a prática de professores da Educação Infantil frente à inclusão de alunos PAEE, principalmente no que diz respeito ao aspecto atitudinal, aqui ressaltado pelas contradições acerca da favorabilidade à inclusão e das práticas pedagógicas inclusivas.

  4. Escolha dos sons-alvo para terapia: análise com enfoque em traços distintivos Choice of target sounds for therapy: analysis focused on distinctive features

    Directory of Open Access Journals (Sweden)

    Marizete Ilha Ceron

    2010-01-01

    Full Text Available Os alvos de tratamento podem dificultar ou facilitar as aquisições no inventário fonológico. Este trabalho tem como objetivo verificar a eficácia da proposta de terapia de Oposições Múltiplas, considerando a escolha dos sons-alvo, e analisar a aquisição de sons no inventário fonológico e os traços distintivos, enfocados a partir dos sons-alvo. O grupo pesquisado constituiu-se de cinco crianças com desvio fonológico, média de idade de 6;1 (anos;meses. Foram realizadas avaliações fonoaudiológicas e complementares. Após as avaliações, os sujeitos foram submetidos à fonoterapia pelo Modelo de Oposições Múltiplas. Depois do tratamento, realizou-se uma reavaliação fonológica, a fim de comparar a evolução terapêutica e a eficácia dos alvos escolhidos para cada sujeito. Compararam-se os inventários fonológicos e o número de traços distintivos alterados pré e pós-terapia em cada sujeito, bem como os traços distintivos enfocados na terapia pelos sons-alvo. Os sujeitos que acrescentaram mais fonemas em seus inventários fonológicos foram os que mais diminuíram o número de traços distintivos alterados. Pode-se concluir que o Modelo de Oposições Múltiplas proporcionou aquisições de fonemas no inventário fonológico, sendo esses relacionados às características dos alvos selecionados para cada sujeito. Os sujeitos cujos sons-alvo contemplavam o trabalho com a maioria dos traços alterados e com sons mais complexos na hierarquia apresentaram maiores aquisições em seus inventários fonológicos.The targets of the treatment can facilitate or difficult acquisitions in the phonological inventory. This study had the aim to verify the effectiveness of the therapy proposed by the Multiple Oppositions Model, taking into consideration the target sounds chosen, as well as to analyze the acquired sounds and the distinctive features, based on the target sounds. The researched group comprised five children with

  5. Anestesia venosa total com infusão alvo-controlada de remifentanil e propofol para ablação de fibrilação atrial

    OpenAIRE

    Nora, Fernando Squeff; Pimentel, Maurício; Zimerman, Leandro Ioschpe; Saad, Eduardo B

    2009-01-01

    JUSTIFICATIVA E OBJETIVOS: A ablação de fibrilação atrial (FA) é um procedimento novo em nosso meio, embora seja comum em outros centros. A escolha da anestesia, monitores e cuidados anestesiológicos para esse procedimento, realizado fora do bloco cirúrgico, não tem sido descrita. O objetivo deste relato foi descrever uma técnica de anestesia para a realização de ablação de FA. RELATO DO CASO: Paciente feminina, 49 anos, 73 kg, 155 cm, ASA II por hipertensão arterial sistêmica. A monitorizaçã...

  6. Shaded Relief of Rio Sao Francisco, Brazil

    Science.gov (United States)

    2000-01-01

    This topographic image acquired by SRTM shows an area south of the Sao Francisco River in Brazil. The scrub forest terrain shows relief of about 400 meters (1300 feet). Areas such as these are difficult to map by traditional methods because of frequent cloud cover and local inaccessibility. This region has little topographic relief, but even subtle changes in topography have far-reaching effects on regional ecosystems. The image covers an area of 57 km x 79 km and represents one quarter of the 225 km SRTM swath. Colors range from dark blue at water level to white and brown at hill tops. The terrain features that are clearly visible in this image include tributaries of the Sao Francisco, the dark-blue branch-like features visible from top right to bottom left, and on the left edge of the image, and hills rising up from the valley floor. The San Francisco River is a major source of water for irrigation and hydroelectric power. Mapping such regions will allow scientists to better understand the relationships between flooding cycles, forestation and human influences on ecosystems.This shaded relief image was generated using topographic data from the Shuttle Radar Topography Mission. A computer-generated artificial light source illuminates the elevation data to produce a pattern of light and shadows. Slopes facing the light appear bright, while those facing away are shaded. On flatter surfaces, the pattern of light and shadows can reveal subtle features in the terrain. Shaded relief maps are commonly used in applications such as geologic mapping and land use planning.The Shuttle Radar Topography Mission (SRTM), launched on February 11, 2000, uses the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. The mission is designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200

  7. 75 FR 65985 - Safety Zone: Epic Roasthouse Private Party Firework Display, San Francisco, CA

    Science.gov (United States)

    2010-10-27

    ... the navigable waters of San Francisco Bay 1,000 yards off Epic Roasthouse Restaurant, San Francisco... waters of San Francisco Bay, 1,000 yards off Epic Roasthouse Restaurant, San Francisco, CA. The fireworks... National Technology Transfer and Advancement Act (NTTAA) (15 U.S.C. 272 note) directs agencies to use...

  8. Francisco de Borja y la corte

    OpenAIRE

    Martínez Millán, José

    2013-01-01

    Català: Francesc de Borja va participar activament en el sistema cortesà dels Àustria espanyols, tant abans com després de l’ingrés a la Companyia. La seva actuació s’emmarca en la facció ebolista, dominant durant la regència de Joana d’Àustria, i explicaria, per exemple, la persecució a què Borja fou sotmès el 1559 per l’inquisidor Fernando de Valdés, membre de la facció albista. Paraules clau: Cort; Francesc de Borja; Inquisició; Partit albista; Partit ebolista. Castellano: Francisco...

  9. De novo Transcriptome Analysis in Perennial Ryegrass

    DEFF Research Database (Denmark)

    Farrell, Jacqueline Danielle; Byrne, Stephen; Asp, Torben

    Perennial ryegrass (Lolium perenne L.) is an important grass species for both forage and amenity purposes for temperate regions worldwide. It is envisaged that breeding efforts may be enhanced with the assistance of new breeding technologies such as genomic selection. A major step towards genomic...... of functional markers for improved ryegrass breeding. Therefore, the goal of this study is to analyze a de novo assembly of the perennial ryegrass transcriptome from the same inbred genotype being used for de novo genome assembly. Furthermore, we also conducted de novo transcriptome assembly with other...

  10. San Francisco-Pacifica Coast Landslide Susceptibility 2011

    Data.gov (United States)

    California Natural Resource Agency — The San Francisco-Pacifica Coast grid map was extracted from the California Geological Survey Map Sheet 58 that covers the entire state of California and originally...

  11. San Francisco-Pacifica Coast Landslide Susceptibility 2011

    Data.gov (United States)

    California Department of Resources — The San Francisco-Pacifica Coast grid map was extracted from the California Geological Survey Map Sheet 58 that covers the entire state of California and originally...

  12. National Status and Trends: Bioeffects Program - San Francisco Bay Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This study was based on the sediment quality triad (SQT) approach. A stratified probabilistic sampling design was utilized to characterize the San Francisco Bay...

  13. San Francisco Bay Interferometric Side Scan Imagery: Area B

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — High resolution sonar data were collected over ultra-shallow areas of the San Francisco Bay estuary system. Bathymetric and acoustic backscatter data were collected...

  14. San Francisco Bay, California 1 arc-second DEM

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1-second San Francisco Bay, California Elevation Grid provides bathymetric data in ASCII raster format of 1-second resolution in geographic coordinates. This...

  15. San Francisco, California Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The San Francisco, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

  16. San Francisco Bay Interferometric Side Scan Imagery: Area A

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Backscatter imagery data were collected over shallow subtidal areas in the San Francisco Bay estuary system. Bathymetric and acoustic backscatter data were collected...

  17. San Francisco Bay Multi-beam Backscatter Imagery: Area A

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Backscatter imagery data were collected over shallow subtidal areas in the San Francisco Bay estuary system. Bathymetric and acoustic backscatter data were collected...

  18. De novo Families: Lesbian Motherhood.

    Science.gov (United States)

    Hayman, Brenda; Wilkes, Lesley

    2017-01-01

    The aim of this recent Australian study was to explore the experiences of lesbian women choosing motherhood. Participants included 30 self-identifying lesbian mothers. Data were collected via interviews, data collection sheets, and online journaling. The interview and journaling data were analyzed using constant comparative analysis and subsequently illuminated three main themes: becoming mothers, constructing motherhood, and legitimizing our family. These papers described the journey to motherhood and specifically explored the various methods of conception and other decisions that participants made when planning their family, the challenge of heteronormativity in health care, and legitimizing the role of the non-birth mother in de novo families. This article aims to present the participants' experiences of motherhood that was a constant topic found woven throughout all three of the identified themes. Participants identified that they had a unique opportunity to create their own mothering roles in the absence of significant "lesbian mother" role models and that they were able to adjust and to adapt their roles depending on fluctuating circumstances.

  19. Plantas transgênicas resistentes a insetos e organismos não-alvo: predadores, parasitóides e polinizadores - doi: 10.5102/ucs.v4i1.23

    OpenAIRE

    Frizzas, Marina Regina; Oliveira, Charles Martins de

    2008-01-01

    Plantas geneticamente modificadas resistentes aos insetos oferecem benefícios à agricultura moderna. No entanto, esta tecnologia pode afetar o controle biológico natural e a biodiversidade por meio de efeitos diretos e indiretos das plantas transgênicas sobre o valor adaptativo e comportamental de predadores, parasitóides, polinizadores e outros artrópodes não-alvo. Neste artigo, são discutidos os impactos ou os efeitos potenciais de plantas transgênicas resistentes a insetos sobre organismos...

  20. O “fluxo” televisual e a audiência alvo em programas jornalísticos: uma análise da revista eletrônica Domingo Espetacular

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Marquioni

    2015-05-01

    Full Text Available O artigo aborda o “fluxo” planejado televisual completo da revista eletrônica semanal Domingo Espetacular, analisando tanto o conteúdo do programa quanto as propagandas comerciais transmitidas enquanto elementos indiciais para decifrar a audiência alvo da emissora. É possível constatar aspectos que remetem à Teologia da Prosperidade no conteúdo veiculado, que revelam uma eventual “estratégia” de referência à igreja evangélica neopentecostal proprietária da emissora mesmo em um programa de TV não religioso.

  1. San Francisco Bay Water Quality Improvement Fund Map Service, San Francisco CA, 2012, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — The San Francisco Bay Water Quality Improvement Fund is a competitive grant program that is helping implement TMDLs to improve water quality, protect wetlands, and...

  2. 2010 Northern San Francisco Bay Area Lidar: Portions of Alameda, Contra Costa, Marin, Napa, San Francisco, Solano, and Sonoma Counties

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Light Detection and Ranging (LiDAR) dataset is a survey of northern San Francisco Bay, California. The project area consists of approximately 437 square miles...

  3. San Francisco Bay Area Baseline Trash Loading Summary Results, San Francisco Bay Area CA, 2012, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — The San Francisco Bay Area stormwater permit sets trash control guidelines for discharges through the storm drain system. The permit covers Alameda, Contra Costa,...

  4. De Novo Arteriovenous Malformation after Aneurysm Clipping.

    Science.gov (United States)

    Shidoh, Satoka; Kobayashi, Masahito; Akaji, Kazunori; Kano, Tadashige; Tanizaki, Yoshio; Mihara, Ban

    2017-07-01

    We report a 73-year-old woman with de novo arteriovenous malformations (AVMs) that developed in the ipsilateral parietal lobe after craniotomy and aneurysm clipping. While intracerebral AVMs are considered to be congenital lesions, there have been several reported cases of acquired AVM arising after ischemic or traumatic episodes. We summarize previously reported cases of such acquired 'de novo' AVMs with a discussion of some pathophysiological responses or factors suggested to promote their development.

  5. Dos nuevas obras de Francisco Gallardo

    Directory of Open Access Journals (Sweden)

    Alonso de la Sierra Fernández, Lorenzo

    2001-09-01

    Full Text Available La localización de dos lienzos firmados por Francisco Gallardo, uno en Sevilla y otro en Cádiz, amplía las escasas noticias que se conocen sobre la vida y obra de este autor. El cuadro de Cádiz, de propiedad particular, es un trampantojo del tipo conocido como «rincón de taller» y sus dimensiones son 83 x 62 cms. En él destaca una estampa, sobre la que se posa una mosca, clavada al habitual fondo de tablas, y en cuya zona inferior se puede leer: «En Cádiz, año de 1720... Franco. Julo. Gallado F.». Bajo la estampa hay una cinta, sujeta con puntas y atravesada en uno de los extremos por un punzón, que sirve de soporte a una carta plegada en la cual aparece escrito: «Sr. Dn. Franco X...». La obra conservada en Sevilla, también de propiedad particular, mide 157 x 108 cms. y representa a santo Tomás de Aquino.…

  6. Considerações a respeito do uso exclusivo de língua-alvo em curso livre: perspectiva dos professores = Considerations towards the exclusive use of the target language in an english course: teachers’ perspectives

    Directory of Open Access Journals (Sweden)

    Kobielski, Natalie Leal

    2010-01-01

    Full Text Available O presente artigo enfoca a perspectiva dos professores de um curso livre que tem como um dos princípios o uso exclusivo da língua-alvo. A partir de uma fundamentação teórica que discute o papel da L1 em diferentes tipos de métodos e abordagens de ensino, que têm por base diferentes teorias de aquisição de linguagem, foi possível discutir sobre as motivações, vantagens e desvantagens do uso da L1 apontadas pelos professores, bem como a coerência entre tais fatores e o que acontece em sala de aula, em suas práticas de ensino. Questionários escritos e gravações de áudio das aulas dos professores constituíram os instrumentos para a coleta dos dados. Por meio deste estudo, foi possível constatar que não somente o bom senso dos professores com relação ao uso exclusivo da língua-alvo é fundamental, mas também que não é possível classificar a prática dos profissionais sob uma única concepção de aquisição de linguagem, ao ser considerada a relação entre teoria e prática dos professores

  7. Breeding avifauna of the south San Francisco Bay estuary

    Science.gov (United States)

    Gill, Robert E.

    1977-01-01

    San Francisco Bay represents one of the largest estuarine areas on the Pacific Coast of North America. Its open waters, tidal flats, tidal marshes and solar evaporation ponds provide critical foraging, resting and breeding habitat for migratory and resident birds. The avifauna of San Francisco Bay has received considerable attention; however, little of it has been directed toward assessing the overall importance of the Bay as a nesting area. Works by Grinnell and Wythe (1927), Grinnell and Miller (1944) and Sibley (1952) are the only comprehensive studies of San Francisco Bay avifauna. These studies, while major contributions, are broad in scope as they relate to the breeding avifauna of the Bay's estuarine areas. Several studies by Johnston (1955, 1956a, b), Marshall (1948a, b), DeGroot (1927, 1931) and Zucca (1954) have concentrated on the breeding biology of individual species; however, much of the marsh reclamation and Bay fill has occurred since. The present breeding status of many resident and migratory birds is poorly known for San Francisco Bay. Included among these are three rare or endangered forms: California Black Rail, California Clapper Rail and California Least Tern. In addition, some species now found in the area represent recent breeding range extensions. This study, undertaken from March to September 1971 and including a few more recent data, presents a quantitative assessment of the present breeding bird populations in the South San Francisco Bay area.

  8. Community Heavy Metal Exposure, San Francisco, California

    Science.gov (United States)

    Chavez, A.; Devine, M.; Ho, T.; Zapata, I.; Bissell, M.; Neiss, J.

    2008-12-01

    Heavy metals are natural elements that generally occur in minute concentrations in the earth's crust. While some of these elements, in small quantities, are vital to life, most are harmful in larger doses. Various industrial and agricultural processes can result in dangerously high concentrations of heavy metals in our environment. Consequently, humans can be exposed to unsafe levels of these elements via the air we breathe, the water and food we consume, and the many products we use. During a two week study we collected numerous samples of sediments, water, food, and household items from around the San Francisco Bay Area that represent industrial, agricultural, and urban/residential settings. We analyzed these samples for Mercury (Hg), Lead (Pb), and Arsenic (As). Our goal was to examine the extent of our exposure to heavy metals in our daily lives. We discovered that many of the common foods and materials in our lives have become contaminated with unhealthy concentrations of these metals. Of our food samples, many exceeded the EPA's Maximum Contaminant Levels (MCL) set for each metal. Meats (fish, chicken, and beef) had higher amounts of each metal than did non-meat items. Heavy metals were also prevalent in varying concentrations in the environment. While many of our samples exceeded the EPA's Sediment Screening Level (SSL) for As, only two other samples surpassed the SSL set for Pb, and zero of our samples exceeded the SSL for Hg. Because of the serious health effects that can result from over-exposure to heavy metals, the information obtained in this study should be used to influence our future dietary and recreational habits.

  9. Café Takksemi - og aðrir tankar úr San Francisco

    DEFF Research Database (Denmark)

    Simonsen, Kim

    2011-01-01

    Travel essay about literature and the image of San Francisco seen through different areas of the city.......Travel essay about literature and the image of San Francisco seen through different areas of the city....

  10. San Francisco urban partnership agreement, national evaluation : transit system data test plan.

    Science.gov (United States)

    2011-06-01

    This report presents the test plan for collecting and analyzing the transit system data for the San Francisco Urban : Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. : The San Francisco UPA pro...

  11. San Francisco urban partnership agreement, national evaluation : cost benefit analysis test plan.

    Science.gov (United States)

    2011-06-01

    This report presents the test plan for collecting and analyzing cost and benefit data for the San Francisco Urban : Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. : The San Francisco UPA proje...

  12. San Francisco urban partnership agreement, national evaluation : exogenous factors test plan.

    Science.gov (United States)

    2011-06-01

    This report presents the test plan for collecting and analyzing exogenous factors data for the San Francisco Urban : Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. : The San Francisco UPA proj...

  13. San Francisco urban partnership agreement, national evaluation : environmental data test plan.

    Science.gov (United States)

    2011-06-01

    This report presents the test plan for collecting and analyzing environmental data for the San Francisco Urban : Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. : The San Francisco UPA projects...

  14. San Francisco urban partnership agreement, national evaluation : telecommuting/TDM data test plan.

    Science.gov (United States)

    2011-06-01

    This report presents the test plan for collecting and analyzing telecommuting/TDM data for the San Francisco Urban Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. The San Francisco UPA projects...

  15. San Francisco urban partnership agreement, national evaluation : traffic system data test plan.

    Science.gov (United States)

    2011-06-01

    This report presents the test plan for collecting and analyzing traffic system data for the San Francisco Urban : Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. : The San Francisco UPA project...

  16. San Francisco urban partnership agreement, national evaluation : traveler information data test plan.

    Science.gov (United States)

    2011-06-01

    This report presents the test plan for collecting and analyzing traveler information data for the San Francisco : Urban Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA : Program. The San Francisco UPA p...

  17. The hemodynamic "target": a visual tool of goal-directed therapy for septic patients Alvo hemodinâmico: uma ferramenta visual de terapia "goal-directed" para pacientes sépticos

    Directory of Open Access Journals (Sweden)

    Fabrice Vallée

    2007-01-01

    compreensão do "status" hemodinâmico de pacientes em sepse pelas equipes de enfermagem através da obtenção de parâmetros hemodinâmicos usando um diagrama-alvo pentaxial como ferramenta clínica. Os parâmetros usados foram índice cardíaco, saturação arterial de oxigênio, pressão arterial media, lactato sangüíneo arterial e saturação venosa central de oxigênio. MÉTODOS: Estudo descritivo prospectivo, realizado na Unidade de Terapia Intensiva de um Hospital Universitário. Pacientes: Durante um período de 6 meses, 38 pacientes intubados em choque séptico foram incluídos no estudo. Foram comparados sobreviventes vs. não sobreviventes. Intervenções: Os cinco parâmetros referidos foram medidos nas horas 0, 6, 12, 24, 36 e 48. As medidas foram registradas no diagrama alvo, juntamente com a velocidade de infusão de norepinefrina e nível de hemoglobina. O número de medidas de lactato e saturação venosa central de oxigênio realizado durante o período de estudo foi comparado com um período retrospectivo de 6 meses imediatamente precedendo a introdução do protocolo. Avaliamos o nível de conhecimento das equipes de enfermagem antes da introdução do diagrama-alvo. Após a realização do protocolo realizamos uma nova avaliação. MEDIDAS E RESULTADOS: A equipe de enfermagem exprimiu uma atitude positiva em relação ao conceito de diagrama alvo. O número de medidas de lactato e saturação venosa central de oxigênio foi significativamente menor durante o período controle anterior ao protocolo. E os valores medidos raramente foram empregados como valores meta antes da introdução do diagrama-alvo. Na medida de 24 horas, 46% dos sobreviventes haviam atingido todas as metas do diagrama-alvo, contra apenas 10% dos não sobreviventes (P = 0,01. CONCLUSÃO. O diagrama-alvo é uma ferramenta visual multiparamétrica envolvendo, as equipes médicas e de enfermagem, que auxilia a obtenção de uma estratégia terapêutica para pacientes sépticos. O n

  18. Vabariigi aastapäev San Franciscos / Heino Valvur ; foto: Heino Valvur

    Index Scriptorium Estoniae

    Valvur, Heino

    2006-01-01

    veebruarikuu möödus San Franciscos Eesti Vabariigi 88. aastapäeva pühitsedes: traditsiooniliselt tähistas aastapäeva San Francisco Seenioride Klubi koosviibimisega, E.E.L.K. San Francisco koguduses peeti jumalateenistus ja koosviibimine, kus noored esitasid rahvalaule, San Francisco Eesti Selts tähistas aastapäeva 25. veebruaril aktuse ja koosviibimisega

  19. Merchandising of cigarettes in San Francisco pharmacies: 27 years later.

    Science.gov (United States)

    Eule, B; Sullivan, M K; Schroeder, S A; Hudmon, K S

    2004-12-01

    To estimate changes since 1976 in the proportion of San Francisco pharmacies that sell cigarettes and to characterise the advertising of cigarettes and the merchandising of non-prescription nicotine replacement therapy (NRT) products in these retail establishments. 100 randomly selected San Francisco pharmacies were visited in 2003. Pharmacies were characterised based on the sale of cigarettes, advertising for cigarettes, and the merchandising of non-prescription NRT products. In 2003, 61% of pharmacies sold cigarettes, a significant decrease compared to 89% of pharmacies selling cigarettes in 1976 (p merchandise the primary known risk factor for death in the USA.

  20. Francisco Pino: el poeta de los agujeros

    Directory of Open Access Journals (Sweden)

    Esperanza Ortega

    2014-03-01

    Full Text Available La obra de Francisco Pino (1910-2002, en sus dos vertientes, experimental y no-experimental, posee una coherencia absoluta en cuanto a su concepción creacionista, que considera el poema como «manifestación de existencia». En este contexto aparecen en los años setenta sus libros de agujeros troquelados, que son su característica más relevante y constituyen una muestra de osadía artística y rebeldía vital. Estos libros de agujeros, minúsculas maquetas del uni-verso, poseen un sentido metafísico-religioso: Pino representa en ellos el vacío y el silencio consustancial a la poesía como música inaudible y espacio invisible, y nos ofrece los planos de una arquitectura poética que comunica con el infinito por medio de la ventana troquelada. Hay una búsqueda de la palabra poética total en toda su obra, desde sus primeros versos, en los que ya aparecen intuiciones reveladoras de sus hallazgos posteriores. Aunque, para Pino, la poesía es búsqueda constante, persecución de una presa inalcanzable. En esa persecución, hallará los caligramas, los libros troquelados y los poemas visua-les realizados en todo tipo de soportes desechables, pues Pino afirmó siempre su deseo de permanecer en la órbita de lo efímero, ajeno al anhelo de eterni-dad y ajeno también a las convenciones de la Historia del Arte, aunque su postura condenara a su obra al ostracismo o la expusiera a la irrisión. En la ilustración de uno de sus últimos libros, el titulado Tejas: lugar de Dios. Obertura, un pájaro se deshace en el poema. Sin trino ni mensaje posible, el poeta recoge la pluma del pájaro y con ella escribe. Así pues, la poesía surge tras la destrucción del poeta, como consecuencia de su disolución en el texto, una inmolación feliz e inexplicable, que inunda de luz cegadora el poema, iluminándole, sin llegar a desvelar su misterio.

  1. 77 FR 50919 - Safety Zone: Wedding Reception Fireworks at Pier 24, San Francisco, CA

    Science.gov (United States)

    2012-08-23

    ...-AA00 Safety Zone: Wedding Reception Fireworks at Pier 24, San Francisco, CA AGENCY: Coast Guard, DHS... navigable waters of the San Francisco Bay near Pier 14 in San Francisco, CA in support of the Wedding... sponsor the Wedding Reception Fireworks at Pier 24 on August 24, 2012, in the navigable waters of the San...

  2. Modular Engineering Concept at Novo Nordisk Engineering

    DEFF Research Database (Denmark)

    Moelgaard, Gert; Miller, Thomas Dedenroth

    1997-01-01

    This report describes the concept of a new engineering method at Novo Nordisk Engineering: Modular Engineering (ME). Three tools are designed to support project phases with different levels of detailing and abstraction. ME supports a standard, cross-functional breakdown of projects that facilitates...

  3. Working Paper for the Revision of San Francisco's Cable Franchise.

    Science.gov (United States)

    San Francisco Public Library, CA. Video Task Force.

    Ideas are presented for the revision of San Francisco's cable franchise. The recommendations in the report are based upon national research of library and urban use of cable communications and are designed to help the city's present and future cable franchises to comply with the regulations of the Federal Communications Commission by March 31,…

  4. Auckland--New Zealand's Los Angeles or San Francisco?

    Science.gov (United States)

    Bogunovich, Dushko

    1995-01-01

    Compares Auckland (New Zealand) with San Francisco (California) in terms of topographical structure, geographic location, and urban development. Both cities contain striking similarities. Maintains that Auckland can become a world-class city renowned for its beauty if developers and government work in tandem. (MJP)

  5. Cultural Factors Related to Smoking in San Francisco's Irish Bars

    Science.gov (United States)

    Satterlund, Travis D.; Antin, Tamar M. J.; Lee, Juliet P.; Moore, Roland S.

    2009-01-01

    California's Smoke-Free Workplace Act was extended to include bars in 1998. While the majority of bars in the state have become smoke free, in many bars patrons and staff continue to smoke despite the law. The authors present findings from a study which assessed cultural factors related to continued smoking in bars in the city of San Francisco. In…

  6. 77 FR 15799 - Notice of Intent To Repatriate a Cultural Item: San Francisco State University, San Francisco, CA

    Science.gov (United States)

    2012-03-16

    .... Representatives of any Indian tribe that believes itself to be culturally affiliated with the cultural item may contact the San Francisco State University NAGPRA Program. DATES: Representatives of any Indian tribe that... research, and museum records, the basket is culturally affiliated with the Santa Rosa Indian Community of...

  7. Extreme-Scale De Novo Genome Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Georganas, Evangelos [Intel Corporation, Santa Clara, CA (United States); Hofmeyr, Steven [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint Genome Inst.; Egan, Rob [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Computational Research Division; Buluc, Aydin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint Genome Inst.; Oliker, Leonid [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint Genome Inst.; Rokhsar, Daniel [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Computational Research Division; Yelick, Katherine [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint Genome Inst.

    2017-09-26

    De novo whole genome assembly reconstructs genomic sequence from short, overlapping, and potentially erroneous DNA segments and is one of the most important computations in modern genomics. This work presents HipMER, a high-quality end-to-end de novo assembler designed for extreme scale analysis, via efficient parallelization of the Meraculous code. Genome assembly software has many components, each of which stresses different components of a computer system. This chapter explains the computational challenges involved in each step of the HipMer pipeline, the key distributed data structures, and communication costs in detail. We present performance results of assembling the human genome and the large hexaploid wheat genome on large supercomputers up to tens of thousands of cores.

  8. MRUniNovo: an efficient tool for de novo peptide sequencing utilizing the hadoop distributed computing framework.

    Science.gov (United States)

    Li, Chuang; Chen, Tao; He, Qiang; Zhu, Yunping; Li, Kenli

    2017-03-15

    Tandem mass spectrometry-based de novo peptide sequencing is a complex and time-consuming process. The current algorithms for de novo peptide sequencing cannot rapidly and thoroughly process large mass spectrometry datasets. In this paper, we propose MRUniNovo, a novel tool for parallel de novo peptide sequencing. MRUniNovo parallelizes UniNovo based on the Hadoop compute platform. Our experimental results demonstrate that MRUniNovo significantly reduces the computation time of de novo peptide sequencing without sacrificing the correctness and accuracy of the results, and thus can process very large datasets that UniNovo cannot. MRUniNovo is an open source software tool implemented in java. The source code and the parameter settings are available at http://bioinfo.hupo.org.cn/MRUniNovo/index.php. s131020002@hnu.edu.cn ; taochen1019@163.com. Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  9. La imagen del arzobispo y cardenal Francisco Antonio de Lorenzana

    Directory of Open Access Journals (Sweden)

    de la Cruz Alcañiz, Cándido

    2010-03-01

    Full Text Available Francisco Antonio de Lorenzana y Buitrón (1722-1804 as an historic personage generates a projection in a continuous image. The author presents and analyses the portraits from his period as Archbishop of Mexico (1766-1772 and those from his period as Archbishop of Toledo (1772-1800, all testimonies of his social activities.

    Francisco Antonio de Lorenzana y Buitrón (1722-1804 como personaje histórico genera una proyección advertida en una imagen continuada. Damos a conocer y analizamos los retratos de su etapa como arzobispo de México (1766-1772 y como arzobispo de Toledo (1772-1800, testimonios de su actividad social.

  10. IDEOLOGIA E TRANSITIVIDADE NO DISCURSO DO PAPA FRANCISCO

    Directory of Open Access Journals (Sweden)

    Vinícius Nicéas Nascimento (UFPE

    2015-09-01

    Full Text Available

    Este artigo tem como objetivo principal apresentar uma análise dos Processos mentais presentes nos pronunciamentos do Papa Francisco proferidos durante a Jornada Mundial da Juventude 2013. Nossa pesquisa fundamentou-se na Linguística Sistêmico-Funcional, na sua concepção da língua como atividade social, e na Análise Crítica do Discurso. Observamos o sistema de transitividade e os diversos processos verbais, bem como os aspectos ideológicos que permearam os pronunciamentos analisados. Os resultados obtidos nos possibilitam perceber que os processos mentais analisados são, nos pronunciamentos do Papa Francisco, corresponsáveis pela construção da argumentação e do sentido e indicam a maneira como a Igreja Católica sustenta suas relações de poder.

  11. Art at the crossroads: Francisco Oller and Caribbean art

    Directory of Open Access Journals (Sweden)

    Katherine Manthorne

    2015-12-01

    Full Text Available Review of Edward J. Sullivan, From San Juan to Paris and Back: Francisco Oller and Caribbean Art in the Era of Impressionism: Francisco Oller (1833-1917 was a Puerto Rican born artist who helped shape the visual production of the Caribbean in the second half of the nineteenth century. He enjoyed a reputation on both sides of the Atlantic, both at home and in Europe, where he spent twenty years. This book fills provides a much-needed analysis of the achievement of Oller, who has received little scholarly attention in the past thirty years. In six chapters that analyze major artworks and themes in Oller’s oeuvre, this book recasts the artist as a key figure in nineteenth century art and sheds new light on his contribution to a uniquely Caribbean aesthetic.

  12. O Desenvolvimento do Enoturismo no Vale do São Francisco: um segmento em expansão

    Directory of Open Access Journals (Sweden)

    Pollyana Pugas Dias

    2012-12-01

    Full Text Available Resumo

    A região do Vale do São Francisco vem se destacando no cenário nacional como o mais novo destino enoturístico. A atividade cresce no mundo como uma alternativa interessante para as regiões vitivinicultoras agregarem valor aos seus produtos e diversificarem a fonte geradora de renda ao mesmo tempo em que envolvem outros setores da região, distribuindo os frutos do seu negócio. Por meio da realização de entrevistas e de uma extensa pesquisa de dados secundários, este trabalho objetivou descrever como esse processo vem se desenvolvendo em pleno semiárido nordestino. Verificou-se como principais evidências do franco crescimento do enoturismo no Vale do São Francisco o envolvimento crescente das vinícolas da região com a atividade, o forte investimento do poder público em prol do segmento e a recente diversificação dos produtos turísticos oferecidos. Os bons resultados que o enoturismo vem apresentando na região podem ser atribuídos ao esforço e integração dos agentes envolvidos e ao contraste de paisagens promovido pela inserção da atividade de fruticultura irrigada, e deve ser interpretada como ferramenta de transformação social e econômica.

    Palavras-chave: turismo; Vale do São Francisco; vitivinicultura. AbstractThe region

  13. CONVERSATORIO CON EL PROFESOR DANIEL FRANCISCO JARAMILLO JARAMILLO

    OpenAIRE

    VICTOR IGNACIO LÓPEZ RÍOS

    2016-01-01

    Daniel Francisco Jaramillo Jaramillo es ingeniero agronomo de la Universidad Nacional de Colombia, especialista de Fotointerpretacion aplicada a estudios de suelos, Magister en Suelos y Aguas de la Universidad Nacional de Colombia, sede Palmira. Ha participado como reconocedor de suelos en levantamientos realizados en varias regiones de los departamentos de Antioquia, Valle del Cauca, Cundinamarca, Huila. Caldas y La Guajira, y desde hace 35 años esta dedicado a la docencia, en pregr...

  14. Assessing urban forest effects and values, San Francisco's urban forest

    Science.gov (United States)

    David J. Nowak; Robert E., III Hoehn; Daniel E. Crane; Jack C. Stevens; Jeffrey T. Walton

    2007-01-01

    An analysis of trees in San Francisco, CA reveals that this city has about 669,000 trees with canopies that cover 11.9 percent of the area. The most common tree species are blue gum eucalyptus, Monterey pine, and Monterey cypress. The urban forest currently stores about 196,000 tons of carbon valued at $3.6 million. In addition, these trees remove about 5,200 tons of...

  15. Aggregate Settling Velocities in San Francisco Estuary Margins

    Science.gov (United States)

    Allen, R. M.; Stacey, M. T.; Variano, E. A.

    2015-12-01

    One way that humans impact aquatic ecosystems is by adding nutrients and contaminants, which can propagate up the food web and cause blooms and die-offs, respectively. Often, these chemicals are attached to fine sediments, and thus where sediments go, so do these anthropogenic influences. Vertical motion of sediments is important for sinking and burial, and also for indirect effects on horizontal transport. The dynamics of sinking sediment (often in aggregates) are complex, thus we need field data to test and validate existing models. San Francisco Bay is well studied and is often used as a test case for new measurement and model techniques (Barnard et al. 2013). Settling velocities for aggregates vary between 4*10-5 to 1.6*10-2 m/s along the estuary backbone (Manning and Schoellhamer 2013). Model results from South San Francisco Bay shoals suggest two populations of settling particles, one fast (ws of 9 to 5.8*10-4 m/s) and one slow (ws of Brand et al. 2015). While the open waters of San Francisco Bay and other estuaries are well studied and modeled, sediment and contaminants often originate from the margin regions, and the margins remain poorly characterized. We conducted a 24 hour field experiment in a channel slough of South San Francisco Bay, and measured settling velocity, turbulence and flow, and suspended sediment concentration. At this margin location, we found average settling velocities of 4-5*10-5 m/s, and saw settling velocities decrease with decreasing suspended sediment concentration. These results are consistent with, though at the low end of, those seen along the estuary center, and they suggest that the two population model that has been successful along the shoals may also apply in the margins.

  16. Copper Toxicity in the San Francisco Bay-Delta

    OpenAIRE

    Buck, Kristen N.

    2012-01-01

    San Francisco Bay has high dissolved copper concentrations—relative to nearby coastal waters—that often approach federal water quality standards put in place to protect sensitive marine life. But, how toxic is this copper? Previous studies by other researchers have suggested that metal-binding compounds known as ligands can “grab up” more than 99.9 percent of the total available dissolved copper in seawater, rendering that copper biologically unavailable. Microorganisms that need tra...

  17. Microbial diversity in restored wetlands of San Francisco Bay

    Energy Technology Data Exchange (ETDEWEB)

    Theroux, Susanna [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Hartman, Wyatt [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; He, Shaomei [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Univ. of Wisconsin, Madison, WI (United States); Tringe, Susannah [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.

    2013-12-09

    Wetland ecosystems may serve as either a source or a sink for atmospheric carbon and greenhouse gases. This delicate carbon balance is influenced by the activity of belowground microbial communities that return carbon dioxide and methane to the atmosphere. Wetland restoration efforts in the San Francisco Bay-Delta region may help to reverse land subsidence and possibly increase carbon storage in soils. However, the effects of wetland restoration on microbial communities, which mediate soil metabolic activity and carbon cycling, are poorly studied. In an effort to better understand the underlying factors which shape the balance of carbon flux in wetland soils, we targeted the microbial communities in a suite of restored and historic wetlands in the San Francisco Bay-Delta region. Using DNA and RNA sequencing, coupled with greenhouse gas monitoring, we profiled the diversity and metabolic potential of the wetland soil microbial communities along biogeochemical and wetland age gradients. Our results show relationships among geochemical gradients, availability of electron acceptors, and microbial community composition. Our study provides the first genomic glimpse into microbial populations in natural and restored wetlands of the San Francisco Bay-Delta region and provides a valuable benchmark for future studies.

  18. Petrogenesis of the Canindé de São Francisco complex: A major Late Proterozoic gabbroic body in the Sergipe Foldbelt, northeastern Brazil

    Science.gov (United States)

    Oliveira, E. P.; Tarney, J.

    The large Canindé de São Francisco gabbroic complex, with its associated volcanic units, has been widely interpreted as a Late Proterozoic island-arc sequence emplaced onto the margin of the São Francisco craton during the development of the Sergipe Foldbelt. Whole-rock major, trace, and rare earth element data and mineral chemistry data are presented here for the Canindé gabbroic complex and the associated Gentileza and Novo Gosto volcanics. These data show that both the gabbros and the volcanics have compositions that bear little resemblance to island-arc sequences. Instead, much of the complex has trace element characteristics that resemble those of continental flood basalts, such as the Paraná. It is more likely that the Canindé Complex has resulted from remobilization of the subcontinental lithosphere during some thermal event in the Late Proterozoic. The Sergipe Foldbelt, therefore, may not necessarily represent a zone of continental collision. Two distinct magma types are recognized in both the gabbro complex and the volcanic sequence. The dominant leucogabbros and the Gentileza basaltic volcanics are relatively enriched in incompatible trace elements and have multi-element patterns that are similar to those Paraná basalts. However, the Novo Gosto volcanics and the FeTi oxide gabbros are much more depleted in light rare earth and other incompatible trace elements, and have more refractory major element compositions. These rocks cannot be related to the rest of the complex by any conceivable scheme involving fractional crystallization. They have more likely resulted from melting of a more refractory mantle component in the subcontinental lithosphere, or they represent second-stage melting of mantle from which a basalt component had already been removed.

  19. Novos paradigmas literários

    Directory of Open Access Journals (Sweden)

    Denise Azevedo Duarte Guimarães

    2005-12-01

    Full Text Available O artigo estuda a emergência de novos paradigmas literários, procurando refletir acerca das textualidades contemporâneas. Focaliza os hipertextos informatizados e a poesia multimídia, com o intuito de desvendar como estão sendo criados novos procedimentos expressivos e em que medida eles podem ser identificados com reflexões teóricas anteriores acerca do texto literário impresso. Remete a questões ligadas à leitura dos diferentes tipos de signos e aos modos como eles se integram para a constituição dessas novíssimas linguagens híbridas em novos suportes.El artículo estudia la emergencia de nuevos paradigmas literarios, procurando reflejar acerca de las textualidades contemporáneas. Enfoca los hipertextos informatizados y la poesía multimedia, intentando desvendar cómo están siendo creados nuevos procedimientos expresivos y en qué medida ellos pueden ser identificados a reflexiones teóricas anteriores acerca del texto literario impreso. Remite a cuestiones ligadas a la lectura de los diferentes tipos de signos y a los modos cómo ellos se interaccionan para la constitución de los novísimos lenguajes híbridos en nuevos supuestos.This article investigates the emergence of new literary paradigms as it tries to understand new contemporary textualities. It analyses some hypertexts and multimedia poetry trying to trace how new expressive procedures are being created. How can these new languages be identified and what are their relations to previous theories which dealt with the literary printed text? This study approaches questions linked to the reading of different types of signs and the modes they function towards the fabrication of these new hybrid languages.

  20. Modeling de novo granulation of anaerobic sludge.

    Science.gov (United States)

    Doloman, Anna; Varghese, Honey; Miller, Charles D; Flann, Nicholas S

    2017-07-17

    A unique combination of mechanical, physiochemical and biological forces influences granulation during processes of anaerobic digestion. Understanding this process requires a systems biology approach due to the need to consider not just single-cell metabolic processes, but also the multicellular organization and development of the granule. In this computational experiment, we address the role that physiochemical and biological processes play in granulation and provide a literature-validated working model of anaerobic granule de novo formation. The agent-based model developed in a cDynoMiCs simulation environment successfully demonstrated a de novo granulation in a glucose fed system, with the average specific methanogenic activity of 1.11 ml C H 4 /g biomass and formation of a 0.5 mm mature granule in 33 days. The simulated granules exhibit experimental observations of radial stratification: a central dead core surrounded by methanogens then encased in acidogens. Practical application of the granulation model was assessed on the anaerobic digestion of low-strength wastewater by measuring the changes in methane yield as experimental configuration parameters were systematically searched. In the model, the emergence of multicellular organization of anaerobic granules from randomly mixed population of methanogens and acidogens was observed and validated. The model of anaerobic de novo granulation can be used to predict the morphology of the anaerobic granules in a alternative substrates of interest and to estimate methane potential of the resulting microbial consortia. The study demonstrates a successful integration of a systems biology approach to model multicellular systems with the engineering of an efficient anaerobic digestion system.

  1. De novo psychogenic seizures after epilepsy surgery: case report

    Directory of Open Access Journals (Sweden)

    MONTENEGRO MARIA AUGUSTA

    2000-01-01

    Full Text Available The occurrence of de novo psychogenic seizures after epilepsy surgery is rare, and is estimated in 1.8% to 3.6%. Seizures after epilepsy surgery should be carefully evaluated, and de novo psychogenic seizures should be considered especially when there is a change in the ictal semiology. We report a patient with de novo psychogenic seizures after anterior temporal lobe removal for refractory temporal lobe epilepsy. Once psychogenic seizures were diagnosed and psychiatric treatment was started, seizures stopped.

  2. De novo pathway-based biomarker identification

    DEFF Research Database (Denmark)

    Alcaraz, Nicolas; List, Markus; Batra, Richa

    2017-01-01

    datasets. Attempts to mitigate these drawbacks have led to the development of network-based approaches that integrate pathway information to produce meta-gene (MG) features. Also, MG approaches have only dealt with the two-class problem of good versus poor outcome prediction. Stratifying patients based...... on their molecular subtypes can provide a detailed view of the disease and lead to more personalized therapies. We propose and discuss a novel MG approach based on de novo pathways, which for the first time have been used as features in a multi-class setting to predict cancer subtypes. Comprehensive evaluation...

  3. Cuidadores de idosos: um novo / velho trabalho

    OpenAIRE

    Resende,Márcia Colamarco Ferreira; Dias,Elizabeth Costa

    2008-01-01

    O texto tem como objetivo discutir as repercussões do novo/velho trabalho dos cuidadores de idosos na sua saúde e o suporte que existe atualmente para eles. O estudo se fundamenta na referência do campo temático da Saúde do Trabalhador. Segundo a literatura, a ocupação de cuidador de idosos parece ser uma atividade exercida predominantemente dentro do setor informal de trabalho, por alguém da família e do sexo feminino, e tem trazido conseqüências na qualidade do cuidado ao idoso e na saúde d...

  4. Novos valores ou nova hierarquia de valores?

    Directory of Open Access Journals (Sweden)

    Vera Rudge Werneck

    2010-04-01

    Full Text Available O artigo tem por objetivo mostrar que não existem novos valores mas sim novas hierarquias de valores. Cada geração em cada tempo e lugar vai hierarquizar os valores diferentemente. Tece uma análise das várias modalidades de valores considerando a sensibilidade como o processo cognitivo próprio para o seu conhecimento. Fundamentando-se teoricamente em Max Scheler, passando para Yvan Gobry, até concluir com um exemplo de hierarquização de valores.

  5. Desenvolvimento de um novo conceito de refrigerante

    OpenAIRE

    Ribeiro, Tânia Isabel Bragança

    2011-01-01

    Dissertação para obtenção de grau de mestre em Tecnologia e Segurança Alimentar – Qualidade Alimentar A indústria de refrigerantes e sumos é um subsector da indústria de bebidas não-alcoólicas, de grande impacte na economia e elevada competitividade. O desenvolvimento de novos produtos e a garantia de qualidade dos produtos são de extrema importância nesta indústria. Actualmente, o consumidor é bastante preocupado com a saúde, procurando produtos que possam não comprometer e/ou impulsionar...

  6. De Novo Construction of Redox Active Proteins.

    Science.gov (United States)

    Moser, C C; Sheehan, M M; Ennist, N M; Kodali, G; Bialas, C; Englander, M T; Discher, B M; Dutton, P L

    2016-01-01

    Relatively simple principles can be used to plan and construct de novo proteins that bind redox cofactors and participate in a range of electron-transfer reactions analogous to those seen in natural oxidoreductase proteins. These designed redox proteins are called maquettes. Hydrophobic/hydrophilic binary patterning of heptad repeats of amino acids linked together in a single-chain self-assemble into 4-alpha-helix bundles. These bundles form a robust and adaptable frame for uncovering the default properties of protein embedded cofactors independent of the complexities introduced by generations of natural selection and allow us to better understand what factors can be exploited by man or nature to manipulate the physical chemical properties of these cofactors. Anchoring of redox cofactors such as hemes, light active tetrapyrroles, FeS clusters, and flavins by His and Cys residues allow cofactors to be placed at positions in which electron-tunneling rates between cofactors within or between proteins can be predicted in advance. The modularity of heptad repeat designs facilitates the construction of electron-transfer chains and novel combinations of redox cofactors and new redox cofactor assisted functions. Developing de novo designs that can support cofactor incorporation upon expression in a cell is needed to support a synthetic biology advance that integrates with natural bioenergetic pathways. © 2016 Elsevier Inc. All rights reserved.

  7. Oil painting on tinplate by Francisco José Resende

    Directory of Open Access Journals (Sweden)

    Ana Rita Veiga

    2010-11-01

    Full Text Available Cet article se concentre sur l'étude des techniques d'exécution, des matériaux et de l'état de conservation de trois peintures à l'huile sur fer-blanc (acier couvert d'étain du peintre portugais Francisco José Resende (1825 – 1893. Bien que le choix de peindre sur un support métallique n'était pas commun au XIXème siècle, cet auteur a exécuté au long de sa vie différentes œuvres sur ce substrat. Dans ces recherches, apparaissent les résultats comparatifs de la technique d'exécution de Francisco Resende et des matériaux présents dans les couches picturales et dans le support des trois œuvres faisant l'objet de l'étude. Bien qu'elles aient été exécutées à des dates similaires, on remarque des problèmes de conservation distincts - notamment les détachements, les cloques et la corrosion -, qui sont décrits et liés aux matériaux constituants des peintures.This article focuses on the study of execution techniques, material composition and condition of three oil paintings on tinplate – a thin sheet of steel coated with tin - by the Portuguese painter Francisco José Resende (1825-1893. Although the choice to paint on a metallic support was not very common in the nineteenth century, the painter executed several works on this support. The comparative results focus on Francisco Resende’s technique of execution, the materials used in the paint layers and on the support of the three works which are being studied. Although executed in the same period, they show different conservation problems - namely delamination and blistering of the paint layers, and also corrosion of the support.

  8. Un héroe civil : Perito Francisco Pascasio Moreno

    OpenAIRE

    Fasano, Héctor L.

    2007-01-01

    La Fundación Museo de la Plata "Francisco Pascasio Moreno”, fundada en 1987, cumple este año sus quince de vida. Acorde con esta condición quinceañera mantiene su espíritu pleno de entusiasmo, de desinterés, de ideales e intocado por desánimo que parece aquejar a tantos compatriotas. Es decir, está situada en una actitud ejemplar de apuesta al futuro en estos años de desesperanzas y extravíos de rumbos. Viene marchando a saludable contrapelo de la realidad. De entre sus proyectos puestos en m...

  9. Swash zone characteristics at Ocean Beach, San Francisco, CA

    Science.gov (United States)

    Erikson, L.H.; Hanes, D.M.; Barnard, P.L.; Gibbs, A.E.

    2007-01-01

    Runup data collected during the summer of 2005 at Ocean Beach, San Francisco, CA are analyzed and considered to be typical summer swash characteristics at this site. Analysis shows that the beach was dissipative with Iribarren numbers between 0.05 and 0.4 and that infragravity energy dominated. Foreshore slopes were mild between 0.01 and 0.05 with swash periods on the order of a minute. Predicted runup heights obtained with six previously developed analytical runup formulae were compared to measured extreme runup statistics. Formulations dependent on offshore wave height, foreshore slope and deep water wavelength gave reasonable results.

  10. Francisco de Vitoria and the root of the criminal law

    Directory of Open Access Journals (Sweden)

    Claudio Brandão

    2017-06-01

    Full Text Available The penal enlightenment was forged as the culmination of a process of bankruptcy paradigms. This is much due to the forward positions that were built before its claims, especially those of natural law rationalists who were based on legal thought of the modern age. In this context, the criminal ideas of Francisco de Vitoria gain considerable importance for understanding the matrix of the criminal law of these days, because they are linked to the enlightenment. Such ideas break the paradigm of the middle ages and replaced in theocentrism by anthropocentrism in the criminal field.

  11. Mercury-contaminated hydraulic mining debris in San Francisco Bay

    Science.gov (United States)

    Bouse, Robin M.; Fuller, Christopher C.; Luoma, Samuel N.; Hornberger, Michelle I.; Jaffe, Bruce E.; Smith, Richard E.

    2010-01-01

    The hydraulic gold-mining process used during the California Gold Rush and in many developing countries today contributes enormous amounts of sediment to rivers and streams. Commonly, accompanying this sediment are contaminants such as elemental mercury and cyanide used in the gold extraction process. We show that some of the mercurycontaminated sediment created by hydraulic gold mining in the Sierra Nevada, between 1852 and 1884, ended up over 250 kilometers (km) away in San Francisco Bay; an example of the far-reaching extent of contamination from such activities.

  12. Custeio-alvo em serviços hospitalares um estudo sob o enfoque da gestão estratégica de custos Target costing in hospital services: a study from a strategic cost management focus

    Directory of Open Access Journals (Sweden)

    Reinaldo Rodrigues Camacho

    2008-08-01

    Full Text Available Neste trabalho, os autores verificaram a viabilidade de aplicação do Custeio-alvo em serviços hospitalares. Como produto-teste da pesquisa, elegeu-se a cesariana realizada por meio de planos de saúde, com internação em apartamentos Standard. Para alcançar os objetivos da pesquisa aplicou-se o método de estudo de caso único e utilizaram-se diversas fontes de dados, tais como: levantamento bibliográfico, aplicação de questionário, realização de entrevistas, observação direta dos processos e atividades e análise e interpretação de relatórios contábeis, financeiros e administrativos da entidade hospitalar objeto do estudo. O questionário foi aplicado a um grupo de cinqüenta mulheres, com o objetivo de verificar sua percepção em relação ao grau de importância de cada um dos principais atributos do produto-teste. As entrevistas, realizadas com os principais gestores da entidade, tiveram o objetivo de verificar como são estabelecidos preços e margens. A análise documental, realizada em planilhas de custos, balancetes e demais relatórios contábeis, financeiros e administrativos, contribuiu para conhecer os procedimentos adotados pela instituição para mensurar e controlar seus custos e receitas. Os resultados mostraram que o processo de Custeio-alvo pode ser aplicado, com sucesso, a entidades hospitalares.In this paper, the authors verified the practicability of applying Target Costing to hospital services. The caesarian section was selected as the research product for testing, carried out in patients hospitalized in a standard room, using a health insurance. To achieve the research aims, the single case study method was used, and also several data sources, such as: bibliographic survey, application of questionnaire, interviews, direct observation of processes and activities, and analysis and interpretation of accounting, financial and administrative reports from the hospital entity chosen for this study. The

  13. Impact of insecticides on non-target arthropods in watermelon cropImpacto de inseticidas em artrópodes não-alvo associados à cultura da melancia

    Directory of Open Access Journals (Sweden)

    Cíntia Ribeiro Souza

    2012-10-01

    Full Text Available Watermelon Citrullus lunatus (Thunberg, Matsumura & Nakai is an ecosystem having a variety of arthropods, each one playing a specific role. Although some of them are considered pest to crops, some others are responsible for soil aeration, nutrient release and predation of pest species and are, therefore, considered beneficial to crops. The intensive farming practiced for watermelon cultivation in Brazil is based on the use of tiamethoxam and deltamethrin, which may not only kill target but also nontarget organisms such as beneficial arthropods. Research data regarding the influence of insecticides on arthropods in watermelon cropping is scarce. This study aimed to evaluate the effect of the insecticides deltamethrin and thiamethoxam on soil surface and watermelon canopy arthropod community. The study was carried out in the State of Tocantins, Brazil. Although the application of thiamethoxam and deltamethrin was efficient in controlling populations of Aphis gossypii (Glover, as we expected, they negatively affected non-target arthropods such as detritivores insects in the canopy and soil surface. Ecological implications of the impact of such pesticides on beneficial arthropod species are discussed.A cultura da melancia Citrullus lunatus (Thunberg, Matsumura & Nakai abriga uma grande diversidade de artrópodes, cada um desempenhando um papel específico. Apesar de alguns desses artrópodes serem considerados pragas, outros são responsáveis pela aeração do solo, liberação de nutrientes e predação das espécies-praga, sendo, dessa forma, considerados benéficos às culturas. A agricultura intensiva praticada no Brasil para o cultivo da melancia é baseada no uso dos inseticidas como tiamethoxam e deltametrina, que pode não só matar as pragas, mas também organismos não-alvo. Pesquisas relacionadas à influência de inseticidas sobre artrópodes benéficos na cultura da melancia são escassas. Este estudo foi realizado com o objetivo de

  14. Custeio Alvo e sua Contribuição para a Implementação das Estratégias de Negócio de uma Subsidiária de Origem Asiática

    Directory of Open Access Journals (Sweden)

    Kelly Cristina Mucio Marques

    2015-08-01

    Full Text Available O objetivo deste estudo é verificar de que forma a empresa utiliza o processo de Custeio Alvo (CA e como ele a auxilia na implementação das suas estratégias. O método empregado foi o estudo de caso único. Para coleta de dados foram utilizou-se de pesquisa documental e de entrevistas semi estruturadas. Para fundamentar a análise foram utilizadas três tipologias de estratégia: a de Porter (1992, de Miles e Snow (2003 e de Gupta e Govindarajan (1984. Como resultado o estudo evidenciou que a empresa adota as estratégias defensora, mantenedora e de diferenciação e que o CA é usado para fornecer informações para planejamento de lucro e controle rígido de custos e implementação dessas estratégias. Conclui-se que não é possível estabelecer, a priori, correlações - biunívocas ou não - entre o uso de determinadas práticas gerenciais e certas posturas estratégicas sem se considerar a forma de utilização das informações – um achado importante. Outra conclusão é que o CA é compatível com posturas estratégicas conservadoras, como defensora e mantenedora, e que essa opção não conflita com a postura de diferenciação.

  15. DIAGRAMMATIC SCALE TO EVALUATE TARGET SPOT SEVERITY IN CUCUMBER PLANT LEAVES ESCALA DIAGRAMÁTICA PARA AVALIAÇÃO DA SEVERIDADE DA MANCHA ALVO EM FOLHAS DE PEPINEIRO

    Directory of Open Access Journals (Sweden)

    Marise Cagnin Martins

    2011-07-01

    -style: normal; font-weight: normal; line-height: 120%; text-decoration: none;" lang="pt-BR">Devido à ausência de escala diagramática para a mancha alvo do pepineiro, causada por Corynespora cassiicola, verificou-se a necessidade de um sistema de quantificação da doença, que proporcionasse maior rapidez e precisão na obtenção dos resultados. Para tanto, uma escala diagramática foi elaborada, considerando-se o limite máximo e mínimo de severidade da doença observados no campo. Os valores intermediários da escala seguiram incrementos logarítmicos para os sintomas da mancha alvo (0,3%; 0,8%; 2%; 5%; 11,5%; 25%; e 46%. Para a validação da escala, oito avaliadores quantificaram a severidade da doença, em cinquenta folhas com diferentes níveis de doença. Inicialmente, a estimativa da severidade foi feita sem auxílio da escala. A seguir, os mesmos avaliadores, utilizando a

  16. Um novo gerador de topologias da Internet.

    OpenAIRE

    Maciel, Joylan Nunes

    2016-01-01

    Dissertação apresentada como requisito parcial para a obtenção do grau de Mestre em Informática no Programa de Pós-Graduação em Informática, Setor de Ciências Exatas, Universidade Federal do Paraná. Orientadora: Profa. Dra. Cristina Duarte Murta. 2008 A geração de topologias sintéticas da Internet tem aplicação fundamental em experimentos com novos protocolos e serviços, propostos com freqüência pela comunidade de pesquisa na área de redes de computadores e sistemas distribuídos. As novas ...

  17. 77 FR 59749 - Special Local Regulations for Marine Events; San Francisco Bay Navy Fleet Week Parade of Ships...

    Science.gov (United States)

    2012-10-01

    ... Local Regulations for Marine Events; San Francisco Bay Navy Fleet Week Parade of Ships and Blue Angels... Francisco Bay for the annual U.S. Navy and City of San Francisco sponsored Fleet Week Parade of Navy Ships... Fleet Week Parade of Ships and Blue Angels Demonstration in accordance with 33 CFR 100.1105. Regulations...

  18. Characteristics of AA amyloidosis patients in San Francisco.

    Science.gov (United States)

    Lejmi, Hiba; Jen, Kuang-Yu; Olson, Jean L; James, Sam H; Sam, Ramin

    2016-04-01

    AA amyloidosis due to subcutaneous injection of drugs of abuse has been described in the USA, but all the existing literature is from more than 20 years ago. There is more recent literature from Europe. We have observed a high incidence of AA amyloidosis in the county hospital in San Francisco. Here, we describe 24 patients who had kidney biopsy-proven AA amyloidosis from our hospital from 1998 to 2013. All the patients were thought to have AA amyloidosis from skin popping of illicit drugs after having exhausted the intravenous route. These patients with biopsy-proven AA amyloidosis were analysed further. All patients were found to have hepatitis C infection, hypertension was not common, most had advanced kidney failure, and acidosis was common as was tubulointerstitial involvement on the kidney biopsy. Other organ involvement included hepatomegaly and splenomegaly in a number of patients; direct myocardial involvement was not seen, but pulmonary hypertension, history of deep vein thrombosis and pulmonary embolism were common. The prognosis of these patients was poor. The mortality rate approached 50% 1 year after biopsy, and most of the patient needed dialysis shortly after diagnosis. Cessation of drug use seemed beneficial but rarely achievable. AA amyloidosis from skin popping is common in San Francisco. Most patients with renal involvement end up on dialysis, and mortality rates are exceedingly high. © 2015 Asian Pacific Society of Nephrology.

  19. Governança corporativa: um novo nome para antigas práticas?

    Directory of Open Access Journals (Sweden)

    Álvaro Ricardino

    2004-12-01

    Full Text Available Em 1754, para tentar reverter a grave crise econômica que se abatia sobre o Estado do Grão-Pará e Maranhão, situado no noroeste do Brasil, o então Governador Francisco Xavier de Mendonça Furtado solicita ao seu irmão, o Marquês de Pombal, Primeiro Ministro de Portugal, que faça esforços junto ao rei para a aprovação de uma companhia de comércio destinada a transportar escravos negros para serem comercializados naquele Estado, como forma de substituir a mão-de-obra indígena, pouco acostumada ao trabalho. Objetivando adiantar o processo e contando apenas com sua memória e experiência, o Governador redigiu e encaminhou ao irmão a minuta dos estatutos daquele empreendimento. Seus vinte e sete parágrafos podem ser considerados avançados para a época e possuem diversos conceitos que hoje são práticas recomendáveis de Governança Corporativa. Considerando-se que mais de duzentos anos separam a iniciativa de Mendonça Furtado dos estudos sobre Governança Corporativa, vale perguntar: Governança Corporativa é um novo nome para antigas práticas?In 1754, in an attempt to revert the serious economic crisis that hit the State of Grão Pará and Maranhão, located in the Northeast of Brazil, the Governor at that time, Francisco Xavier de Mendonça Furtado, asked his brother, the Marquis of Pombal, Prime Minister of Portugal, to make his best effort at the royal palace to approve a trading company aimed at transporting black slaves to be traded in that state, in order to substitute for indigenous workforce, which was little accustomed to this work. With a view to fastening the process, on the mere basis of his memory and experience, the Governor wrote and sent his brother the minutes of that company's bylaws. His twenty-seven paragraphs can be considered ahead of their time and contain various concepts recommended as Corporate Governance practices nowadays. Considering that there are more than two hundred years between Mendon

  20. Coastal Adaptation: The Case of Ocean Beach, San Francisco

    Science.gov (United States)

    Cheong, S.

    2012-12-01

    Coastal erosion, storms, sea-level rise, and tsunamis all lead to inundation that puts people and communities at risk. Adapting to these coastal hazards has gained increasing attention with climate change. Instead of promoting one particular strategy such as seawalls or defending against one type of hazard, scholars and practitioners encourage a combination of existing methods and strategies to promote synergistic effects. The recently published Intergovernmental Panel on Climate Change (IPCC) Special Report on climate extremes reflects this trend in the integration of disaster risk management and climate change adaptation. This paper focuses on the roles, compatibilities, and synergies of three coastal adaptation options - engineering, vegetation, and policy - in the case of Ocean Beach in San Francisco. Traditionally engineering approach and ecosystem conservation often have stood in opposition as hard shoreline structures destroy coastal habitats, worsen coastal erosion, divert ocean currents, and prevent the natural migration of shores. A natural migration of shores without structure translates into the abandonment of properties in the coastal zone, and is at odds with property rights and development. For example, policies of relocation, retreat, and insurance may not be popular given the concerns of infrastructure and coastal access. As such, engineering, natural defense, and policy can be more conflictual than complementary. Nonetheless, all these responses are used in combination in many locations. Complementarities and compatibilities, therefore, must be assessed when considering the necessity of engineering responses, natural defense capabilities, and policy options. In this light, the question is how to resolve the problem of mixed responses and short- and long-term interests and values, identify compatibilities, and generate synergies. In the case of Ocean Beach, recent erosions that endangered San Francisco's wastewater treatment system acted as major

  1. Marcelo Caetano : últimas razones del Estado Novo

    Directory of Open Access Journals (Sweden)

    Hipólito de la Torre Gómez

    2007-01-01

    Full Text Available El reformismo de Marcelo Caetano, ensayado durante sus años de gobierno, resultó insuficiente para responder a los desafíos de la sociedad portuguesa, que acabaron por desembocar en la ruptura del 25 de Abril. Las razones del fracaso de la reforma marcelista se han atribuido a menudo a las dificultades del Presidente del Consejo para maniobrar, prácticamente sin margen y sin tiempo, entre poderosas presiones políticas contrapuestas. Sin embargo, el análisis de su pensamiento político, expreso en las manifestaciones realizadas durante los años de su Gobierno, revelan que en lo sustancial su ideario nunca se salió de los parámetros ideológicos y políticos del Estado Novo. Su reformismo no iba más allá de un intento honesto de relegitimar el régimen mediante un proceso de efectiva institucionalización de la actividad política, de dinamización representativa, de modernización socioeconómica y de aperturismo liberalizador.The reformist policy of Marcelo Caetano was incapable of overcoming the challenges of Portuguese society that eventually led to the outbreak of 25th April. The reasons for this failure have been often linked to the President’s difficulties to implement changes in the midst of powerful and opposed political pressures. Nevertheless, the analysis of his political thought expressed in the speeches and statements produced during his government period, shows that essentially marcelist’s ideas never exceeded the «Estado Novo» ideological framework. So, his reforming policy never went beyond an honest attempt to renew the regime throughout a more institutionalised and representative political practice, a deeper tolerance of public liberties and an economic and social modernization. All that could at the ouset raise popular hopes, but it could never flow into democracy.

  2. Los "intelectuales" y el Estado Novo

    Directory of Open Access Journals (Sweden)

    Luís REIS TORGAL

    2010-02-01

    Full Text Available RESUMEN: El concepto de “intelectual” es difícil de definir y sin duda se debate constantemente. Sin embargo, es importante reflexionar sobre él a fin de comprender su significado y los problemas que implica. Sea como fuere, a un Estado autoritario “moderno” se le supone una única ideología que tiene que difundirse por medio de una propaganda bien organizada, proceso en el que los intelectuales desempeñan un papel significativo. El “Nuevo Estado” de Salazar encaja en esta categoría y sin duda el conocimiento acerca de sus “intelectuales” es fundamental. En este artículo, el objetivo es proporcionar algunos ejemplos interesantes de “intelectuales” o de simples “funcionarios políticos” con inclinación intelectual a fin de indicar el sentido y complejidad de un estudio con una dimensión distinta sobre este asunto. A este fin han sido seleccionadas tres personalidades responsables de la actividad ideológica y cultural de gran relieve en el Estado de Salazar: António Ferro, João Ameal y Costa Brochado. Palabras clave: Estado Novo; Authotitarianism; Salazar, António de Oliveira; Intellectuals; Ferro, António; Brochado, Idalino da Costa; Ameal, João. ABSTRACT: The concept of the “intellectual” is difficult to define and undoubtedly constantly debated. It is nevertheless important to reflect on it in order to understand its meaning and the problems involved with it. Be that as it may, a “modern” authoritarian State presumes a single ideology which has to be diffused by means of well-organised propaganda, in which process “intellectuals” play a significant role. Salazar’s “New State” fits this category and, undoubtedly, knowledge about its “intellectuals” is fundamental. The objective in this article is to provide some interesting examples of “intellectuals” or simple “political functionar- ies” with an intellectual bent so as to indicate the sense and complexity of a study of a

  3. Teresa Gowan, Hobos, Hustlers and Backsliders: Homeless in San Francisco

    Directory of Open Access Journals (Sweden)

    João Aldeia

    2012-11-01

    Full Text Available Teresa Gowan apresenta‑nos uma obra atípica no contexto da produção de conhecimento científico sobre o fenómeno dos sem‑abrigo nos Estados Unidos da América (EUA. Recorrendo a um trabalho etnográfico notável, desenvolvido ao longo da segunda metade da década de 1990 em São Francisco, a autora enquadra o seu estudo no contexto sócio-histórico e geográfico mais vasto, articulando a análise do terreno com as teorias acerca do fenómeno e com os registos das perspectivas das próprias pessoas que ...

  4. El doctor Francisco Guerra, bibliófilo

    OpenAIRE

    Sánchez Mariana, Manuel

    2007-01-01

    Biografía del doctor Francisco Guerra, médico y uno de los bibliófilos más representativos de comienzos del s. XXI, poseedor de una importantísima biblioteca, donada por decisión propia, en el año 2006 a la Biblioteca Histórica de la Universidad Complutense. La biblioteca está compuesta por más de 4000 impresos y manuscritos de una variada seleccion de títulos humanísticos y científicos: clásicos griegos, romanos y españoles, clásicos de economía, descubrimiento de América, crónicas españolas...

  5. Microplastic contamination in the San Francisco Bay, California, USA.

    Science.gov (United States)

    Sutton, Rebecca; Mason, Sherri A; Stanek, Shavonne K; Willis-Norton, Ellen; Wren, Ian F; Box, Carolynn

    2016-08-15

    Despite widespread detection of microplastic pollution in marine environments, data describing microplastic abundance in urban estuaries and microplastic discharge via treated municipal wastewater are limited. This study presents information on abundance, distribution, and composition of microplastic at nine sites in San Francisco Bay, California, USA. Also presented are characterizations of microplastic in final effluent from eight wastewater treatment plants, employing varying treatment technologies, that discharge to the Bay. With an average microplastic abundance of 700,000particles/km(2), Bay surface water appears to have higher microplastic levels than other urban waterbodies sampled in North America. Moreover, treated wastewater from facilities that discharge into the Bay contains considerable microplastic contamination. Facilities employing tertiary filtration did not show lower levels of contamination than those using secondary treatment. As textile-derived fibers were more abundant in wastewater, higher levels of fragments in surface water suggest additional pathways of microplastic pollution, such as stormwater runoff. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Selenium and heavy metals in San Francisco Bay diving ducks

    Science.gov (United States)

    Ohlendorf, H.M.; Lowe, Roy W.; Kelly, P.R.; Harvey, T.E.

    1986-01-01

    We analyzed for selenium (Se) and heavy metals in greater scaups (Aythya marila) and surf scoters (Melanitta perspicillata) collected from southern San Francisco Bay in March and April 1982. There were no differences (P > 0.05) between species for liver concentrations of silver (Ag), mercury (Hg), or lead (Pb). Copper (Cu) (P 0.05) between the 2 species. The geometric mean cadmium (Cd) concentration in scoter kidneys (24.6 ppm, dry wt) was higher than in scaups (15.5 ppm) (0.1 > P > 0.05). Liver concentrations of Hg and Se were correlated (P < 0.01). The toxicological significance of some elements in these species is not known. However, Se levels in scoters (34.4 ppm, dry wt) were similar to those in livers of dabbling ducks (Anas spp.) in the nearby San Joaquin Valley where reproduction was impaired severely.

  7. [Diagnosis and management of de novo epilepsy].

    Science.gov (United States)

    Louise, Tyvaert

    2018-03-01

    The diagnosis of de novo epilepsy is complex. An accurate diagnostic approach has to be followed based on specific key steps. Epileptic seizure or non-epileptic malaise: risk of diagnosis error around 20%. Facing a first unprovoked seizure, the practitioner has to know the risk factors specifically linked to an increase risk of seizure recurrence. In presence of these factors, an antiepileptic drug would be indicated. The first antiepileptic drug has to be highly selected according to the epilepsy type and causes but also to the patient characteristics (sex, age, comorbidities, associated drugs, profession, and way of life…) An exhaustive patient Education needs to support the first antiepileptic drug prescription: (sleep and nutritional advices, benefit of observance, antiepileptic drugs features and side effects, follow-up, prognosis…) A regular follow-up is essential to control the observance, tolerability and efficacy of the antiepileptic drug, and to control also the good acceptance of the disease. A systematic research of common comorbidities may be also performed. Electroencephalogram and antiepileptic drugs levels are unnecessary in the classical follow up of known epileptic patients (except specific cases). Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  8. Wave attenuation across a tidal marsh in San Francisco Bay

    Science.gov (United States)

    Foster-Martinez, Madeline R.; Lacy, Jessica; Ferner, Matthew C.; Variano, Evan A.

    2018-01-01

    Wave attenuation is a central process in the mechanics of a healthy salt marsh. Understanding how wave attenuation varies with vegetation and hydrodynamic conditions informs models of other marsh processes that are a function of wave energy (e.g. sediment transport) and allows for the incorporation of marshes into coastal protection plans. Here, we examine the evolution of wave height across a tidal salt marsh in San Francisco Bay. Instruments were deployed along a cross-shore transect, starting on the mudflat and crossing through zones dominated by Spartina foliosa and Salicornia pacifica. This dataset is the first to quantify wave attenuation for these vegetation species, which are abundant in the intertidal zone of California estuaries. Measurements were collected in the summer and winter to assess seasonal variation in wave attenuation. Calculated drag coefficients of S. foliosa and S. pacifica were similar, indicating equal amounts of vegetation would lead to similar energy dissipation; however, S. pacifica has much greater biomass close to the bed (<20 cm) and retains biomass throughout the year, and therefore, it causes more total attenuation. S. foliosa dies back in the winter, and waves often grow across this section of the marsh. For both vegetation types, attenuation was greatest for low water depths, when the vegetation was emergent. For both seasons, attenuation rates across S. pacifica were the highest and were greater than published attenuation rates across similar (Spartina alterniflora) salt marshes for the comparable depths. These results can inform designs for marsh restorations and management plans in San Francisco Bay and other estuaries containing these species.

  9. Al margen de las Obras de Francisco de la Torre

    Directory of Open Access Journals (Sweden)

    Pérez-Abadín Barro, Soledad

    2003-12-01

    Full Text Available Francisco de la Torre's Works, published by Quevedo in 1631, enclose a second part, described in later years as an «appendix», with translations that did not belong in the original project prepared by the author some decades before. The summary of the 1588 license for printing describes the work's content as «lyric and adonic verse, and bucolic», without mentioning the translations. The new date throws into question the participation of Almeida and Brocense in the preparation and transmission of the manuscript that came to Quevedo. Therefore, the volume of 1631 cannot be considered as an example of salmantin group's collective poetical essay. Related chronological considerations also throw new light on the relationship between the author and Fernando de Herrera.Las Obras de Francisco de la Torre, publicadas por Quevedo en 1631, incluyen una segunda parte, que más tarde se llamaría «apéndice», con traducciones ajenas al proyecto inicial preparado por el propio autor décadas antes. El sumario de la licencia de impresión de 1588 describe el contenido de la obra aprobada como «los versos líricos y adónicos y la bucólica», sin mencionar las traducciones. La nueva fecha lleva a cuestionar el protagonismo de Almeida y el Brócense en la preparación y transmisión del manuscrito que más tarde llegaría a Quevedo. El volumen de 1631, por lo tanto, no puede considerarse como un exponente de un ejercicio poético colectivo del círculo salmantino. Los datos cronológicos también permiten replantear la relación del autor con Fernando de Herrera.

  10. De novo origin of human protein-coding genes.

    Directory of Open Access Journals (Sweden)

    Dong-Dong Wu

    2011-11-01

    Full Text Available The de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Here we identify 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee. The functionality of these genes is supported by both transcriptional and proteomic evidence. RNA-seq data indicate that these genes have their highest expression levels in the cerebral cortex and testes, which might suggest that these genes contribute to phenotypic traits that are unique to humans, such as improved cognitive ability. Our results are inconsistent with the traditional view that the de novo origin of new genes is very rare, thus there should be greater appreciation of the importance of the de novo origination of genes.

  11. De Novo Coding Variants Are Strongly Associated with Tourette Disorder

    DEFF Research Database (Denmark)

    Willsey, A Jeremy; Fernandez, Thomas V; Yu, Dongmei

    2017-01-01

    damaging missense) are overrepresented in probands (RR 1.37, p = 0.003). We identify four likely risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3), NIPBL (Nipped-B-like), and FN1...... trios from the Tourette Syndrome Association International Consortium on Genetics (511 total). We observe strong and consistent evidence for the contribution of de novo likely gene-disrupting (LGD) variants (rate ratio [RR] 2.32, p = 0.002). Additionally, de novo damaging variants (LGD and probably...... (fibronectin 1). Overall, we estimate that de novo damaging variants in approximately 400 genes contribute risk in 12% of clinical cases. VIDEO ABSTRACT....

  12. De Novo Origin of Human Protein-Coding Genes

    Science.gov (United States)

    Wu, Dong-Dong; Irwin, David M.; Zhang, Ya-Ping

    2011-01-01

    The de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Here we identify 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee. The functionality of these genes is supported by both transcriptional and proteomic evidence. RNA–seq data indicate that these genes have their highest expression levels in the cerebral cortex and testes, which might suggest that these genes contribute to phenotypic traits that are unique to humans, such as improved cognitive ability. Our results are inconsistent with the traditional view that the de novo origin of new genes is very rare, thus there should be greater appreciation of the importance of the de novo origination of genes. PMID:22102831

  13. REVIEW ARTICLE Case report of newborn with de novo partial ...

    Indian Academy of Sciences (India)

    Navya

    2017-03-24

    2 2q37.3 and a de novo monosomy 9p24.3. The clinical findings of this patient include congenital heart defects, dysmorphic facial features, hypotonia, feeding difficulties and microcephaly. Ultrasonographic prenatal findings ...

  14. Language and national identity in Novo Cinema Galego

    Directory of Open Access Journals (Sweden)

    Brais ROMERO SUÁREZ

    2015-12-01

    Full Text Available The talk of town since its inception in 2010, the Cinema Novo Galego has been successful in all competitions and festivals that has been present. From the FIPRESCI prize in Cannes to the Best Emerging Director at Locarno, this new wave of cinema places Galicia in the world film stage. But does Novo Cinema Galego an accurate representation of Galicia? What's the role of Galicia in this movement?

  15. NovoFLAP: A ligand-based de novo design approach for the generation of medicinally relevant ideas.

    Science.gov (United States)

    Damewood, James R; Lerman, Charles L; Masek, Brian B

    2010-07-26

    NovoFLAP is a computer-aided de novo design tool that generates medicinally relevant ideas for ligand-based projects. The approach combines an evolutionary algorithm (EA-Inventor) with a powerful ligand-based scoring function that uses both molecular shape and pharmacophore features in a multiconformational context (FLAP). We demonstrate that NovoFLAP can generate novel ideas that are not only appealing to design scientists but are also validated by comparison to compounds known to demonstrate activity at the desired biological target. NovoFLAP provides a novel computer-aided design technique that can be used to generate ideas that maintain desirable molecular attributes, such as activity at the primary biological target, while offering opportunities to surmount additional design challenges. Application to the design of the first nonbasic 5HT(1B) antagonist is presented.

  16. Stream Habitat Reach Summary - San Francisco Bay, Central Coast [ds159

    Data.gov (United States)

    California Department of Resources — The Stream Habitat - San Francisco Bay, Central and South Coasts [ds159] shapefile contains four years of in-stream salmonid habitat data at the reach level. The...

  17. Coastal processes study at Ocean Beach, San Francisco, CA: summary of data collection 2004-2006

    Science.gov (United States)

    Barnard, Patrick L.; Eshleman, Jodi; Erikson, Li H.; Hanes, Daniel M.

    2007-01-01

    Ocean Beach in San Francisco, California, contains a persistent erosional section in the shadow of the San Francisco ebb tidal delta and south of Sloat Boulevard that threatens valuable public infrastructure as well as the safe recreational use of the beach. Coastal managers have been discussing potential mediation measures for over a decade, with little scientific research available to aid in decision making. The United States Geological Survey (USGS) initiated the Ocean Beach Coastal Processes Study in April 2004 to provide the scientific knowledge necessary for coastal managers to make informed management decisions. This study integrates a wide range of field data collection and numerical modeling techniques to document nearshore sediment transport processes at the mouth of San Francisco Bay, with emphasis on how these processes relate to erosion at Ocean Beach. The Ocean Beach Coastal Processes Study is the first comprehensive study of coastal processes at the mouth of San Francisco Bay.

  18. San Francisco urban partnership agreement, national evaluation : content analysis test plan.

    Science.gov (United States)

    2011-06-01

    This report presents the test plan for collecting and analyzing information on outreach activities, media coverage, : and reactions of the public, policy makers, and other groups to the UPA projects for the San Francisco Urban : Partnership Agreement...

  19. BACTERIOPLANKTON DYNAMICS IN NORTHERN SAN FRANCISCO BAY: ROLE OF PARTICLE ASSOCIATION AND SEASONAL FRESHWATER FLOW

    Science.gov (United States)

    Bacterioplankton abundance and metabolic characteristics were observed in northern San Francisco Bay, California, during spring and summer 1996 at three sites: Central Bay, Suisun Bay, and the Sacramento River. These sites spanned a salinity gradient from marine to freshwater, an...

  20. Francisco de Valderrama, verdadero autor de las mazas del Ayuntamiento de Sevilla

    Directory of Open Access Journals (Sweden)

    Santos Márquez, Antonio Joaquín

    2009-06-01

    Full Text Available In this article the author reveals the true creator of the maces of Seville Town Hall, Francisco de Valderrama, a rediscovered silversmith about whom new biographical data is offered. Also included is a detailed study of these civic maces (traditionally attributed erroneously to Francisco de Alfaro, key works of Sevillian Mannerism.

    En este artículo se da a conocer el verdadero autor de las mazas del ayuntamiento de Sevilla, Francisco de Valderrama, orfebre redescubierto del que además aportamos nuevos datos biográficos. Asimismo, hacemos un estudio pormenorizado de estas mazas capitulares, obra clave de la plástica manierista sevillana y que tradicionalmente había sido atribuida erróneamente a Francisco de Alfaro.

  1. Physical and chemical properties of San Francisco Bay waters, 1969-1976 (NODC Accession 8400194)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — One magnetic tape containing the physical and chemical properties of San Francisco Bay waters was forwarded to NODC by Mr. Richard Smith of the U.S Geological Survey...

  2. Volcanic rocks of the eastern and northern parts of the San Francisco volcanic field, Arizona

    Science.gov (United States)

    Moore, Richard B.; Wolfe, Edward W.; Ulrich, George E.

    1976-01-01

    The eastern and northern parts of the San Francisco volcanic field, between San Francisco Mountain and the Little Colorado River, contain about 175 cinder cones, many with one or more associated lava flows, and one center of silicic volcanism, O'Leary Peak. Basaltic flows and cones are divided into five groups, primarily on the bases of stratigraphic and physiographic relations, degree of weathering and erosion, K-Ar and tree-ring age determinations, and, in part, chemical and petrographic data:

  3. Optimization of the daily operation of the plants of Medio Sao Francisco; Otimizacao da operacao diaria das usinas do Medio Sao Francisco

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Jessica Pillon Torralba; Colnago, Glauber Renato; Correia, Paulo de Barros; Ohishi, Takaaki [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Fac. de Engenharia Mecanica. Dept. de Energia], emails: pillon@fem.unicamp.br, colnago@fem.unicamp.br, pcorreia@fem.unicamp.br, taka@densis.fee.unicamp.br

    2010-07-01

    This paper presents an optimization model for daily operation of Sao Francisco hydroelectric power plants. The study considers eight power plants - Sobradinho (USB), Luiz Gonzaga (ULG), Apolonio Sales (UAS), Paulo Afonso I, II, III, (UPA), Paulo Afonso IV (USQ) e Xingo (UXG)- belongs to Sao Francisco Hydroelectric Company (CHESF). Its objective is to maximize the power plant efficiency and to minimize the number of startup and shutdowns of generating units (GU), simultaneously. Considering those GU are equal, is determined the number of units to be dispatched and their charge. The optimal dispatch, linear and non-linear programming techniques and genetic algorithms (GA) support this article. (author)

  4. Anestesia venosa total com infusão alvo-controlada de remifentanil e propofol para ablação de fibrilação atrial Anestesia venosa total con infusión objeto-controlada de remifentanil y propofol para ablación de la fibrilación atrial Total intravenous anesthesia with target-controlled infusion of remifetanil and propofol for ablation of atrial fibrillation

    Directory of Open Access Journals (Sweden)

    Fernando Squeff Nora

    2009-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A ablação de fibrilação atrial (FA é um procedimento novo em nosso meio, embora seja comum em outros centros. A escolha da anestesia, monitores e cuidados anestesiológicos para esse procedimento, realizado fora do bloco cirúrgico, não tem sido descrita. O objetivo deste relato foi descrever uma técnica de anestesia para a realização de ablação de FA. RELATO DO CASO: Paciente feminina, 49 anos, 73 kg, 155 cm, ASA II por hipertensão arterial sistêmica. A monitorização constou de eletrocardiograma com 12 derivações, oximetria de pulso, frequência cardíaca, eletroencefalografia bispectral para medidas de BIS, taxa de supressão (SR e SEF95 e pressão arterial média (PAM. A indução anestésica foi realizada com propofol por via venosa, em infusão alvo-controlada (IAC, com alvo regulado em 4 µg.mL-1, remifentanil por via venosa, em IAC, com alvo de 3 ng.mL¹, e rocurônio por via venosa em bolus na dose de 0,2 mg.kg-1. O modelo farmacocinético de propofol utilizado foi o descrito por Marsh e incorporado à bomba de propofol PFS®. O modelo farmacocinético de remifentanil utilizado foi o descrito por Minto e incorporado à bomba de infusão Alaris PK®. As concentrações, no local efetor ou biofase, corresponderam às informações obtidas através das bombas de infusão e representaram medidas preditivas das concentrações de ambos os fármacos nos respectivos locais de ação. As concentrações de propofol e de remifentanil foram reguladas de acordo com o BIS e a PAM, respectivamente. CONCLUSÕES: A anestesia venosa total para ablação de FA pode ser uma opção segura, levando-se em conta que não há alteração da eletrofisiologia das vias acessórias. A literatura é escassa a este respeito e novas publicações poderão ou não justificar esta modalidade de anestesia durante ablação de FA.JUSTIFICATIVA Y OBJETIVOS: La ablación de fibrilación atrial (FA es un procedimiento nuevo en

  5. Clinicopathologic factors associated with de novo metastatic breast cancer.

    Science.gov (United States)

    Shen, Tiansheng; Siegal, Gene P; Wei, Shi

    2016-12-01

    While breast cancers with distant metastasis at presentation (de novo metastasis) harbor significantly inferior clinical outcomes, there have been limited studies analyzing the clinicopathologic characteristics in this subset of patients. In this study, we analyzed 6126 breast cancers diagnosed between 1998 and 2013 to identify factors associated with de novo metastatic breast cancer. When compared to patients without metastasis at presentation, race, histologic grade, estrogen/progesterone receptor (ER/PR) and HER2 statuses were significantly associated with de novo metastasis in the entire cohort, whereas age, histologic grade, PR and HER2 status were the significant parameters in the subset of patients with locally advanced breast cancer (Stage IIB/III). The patients with de novo metastatic breast cancer had a significant older mean age and a lower proportion of HER2-positive tumors when compared to those with metastatic recurrence. Further, the HER2-rich subtype demonstrated a drastically higher incidence of de novo metastasis when compared to the luminal and triple-negative breast cancers in the entire cohort [odds ratio (OR)=5.68 and 2.27, respectively] and in the patients with locally advanced disease (OR=4.02 and 2.12, respectively), whereas no significant difference was seen between de novo metastatic cancers and those with metastatic recurrence. Moreover, the luminal and HER2-rich subtypes showed bone-seeking (OR=1.92) and liver-homing (OR=2.99) characteristics, respectively, for the sites of de novo metastasis, while the latter was not observed in those with metastatic recurrence. Our data suggest that an algorithm incorporating clinicopathologic factors, especially histologic grade and receptor profile, remains of significant benefit during decision making in newly diagnosed breast cancer in the pursuit of precision medicine. Copyright © 2016 Elsevier GmbH. All rights reserved.

  6. Comunidade bacteriana como indicadora do efeito de feijoeiro geneticamente modificado sobre organismos não alvo Bacterial community as an indicator of genetically modified common bean effect on nontarget organisms

    Directory of Open Access Journals (Sweden)

    Adriano Moreira Knupp

    2009-12-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito do feijoeiro geneticamente modificado quanto à resistência ao Bean Golden Mosaic Vírus, BGMV (Olathe M1-4, sobre organismos não alvo. De um experimento implantado no campo, em delineamento inteiramente casualizado, com dois tratamentos (Olathe Pinto e evento elite Olathe M1-4, dois períodos amostrais (estádio V4 e R6 e dez repetições, obtiveram-se células bacterianas cultivadas e não cultivadas da rizosfera e do solo não rizosférico, para as quais se procedeu à extração de DNA total. A região V6-V8 do 16S rDNA foi amplificada para a comunidade bacteriana total, e também realizou-se amplificação com iniciadores específicos para o subgrupo alfa (α do filo Proteobacteria a partir de células não cultivadas. Foram obtidos dendrogramas comparativos entre a variedade Olathe Pinto (convencional e o evento elite Olathe M1-4 (geneticamente modificado utilizando-se o coeficiente de Jaccard e o método UPGMA (Unweighted pair-group method with arithmetic mean. Os agrupamentos obtidos dos perfis de 16S rDNA PCR-DGGE indicam alterações na comunidade bacteriana da rizosfera em função da transformação das plantas são mais notáveis nos perfis obtidos para alfa-proteobacteria. A origem das amostras e o estágio de desenvolvimento das plantas afetam a comunidade bacteriana.The objective of this work was to evaluate the effect of genetically modified common bean for Bean Golden Mosaic Virus, BGMV, resistance (Olathe M1-4 on nontarget organisms. In a field experiment established in a completely randomized design with two treatments (Olathe Pinto cultivar and M1-4 Olathe elite event, two sampling periods (V4 and R6 stages and ten replicates, cultivated and non-cultivated bacterial cells from rhizosphere soil and bulk soil were obtained, and their total DNA was extracted. The V6-V8 region of 16S rDNA was amplified for the whole bacterial community, and primers specific for the alpha (

  7. Mercury-Contaminated Hydraulic Mining Debris in San Francisco Bay

    Directory of Open Access Journals (Sweden)

    Robin M Bouse

    2010-05-01

    Full Text Available The hydraulic gold-mining process used during the California Gold Rush and in many developing countries today contributes enormous amounts of sediment to rivers and streams. Commonly, accompanying this sediment are contaminants such as elemental mercury and cyanide used in the gold extraction process. We show that some of the mercury-contaminated sediment created by hydraulic gold mining in the Sierra Nevada, between 1852 and 1884, ended up over 250 kilometers (km away in San Francisco Bay; an example of the far-reaching extent of contamination from such activities. A combination of radionuclide dating, bathymetric reconstruction, and geochemical tracers were used to distinguish the hydraulic mining sediment from sediment deposited in the bay before hydraulic mining started (pre-Gold Rush sediment and sediment deposited after hydraulic mining stopped (modern sediment. Three San Francisco Bay cores were studied as well as source material from the abandoned hydraulic gold mines and river sediment between the mines and bay. Isotopic and geochemical compositions of the core sediments show a geochemical shift in sediment deposited during the time of hydraulic mining. The geochemical shift is characterized by a decrease in εNd, total organic carbon (TOC, Sr and Ca concentrations, Ca/Sr, and Ni/Zr; and, an increase in 87Sr/86Sr, Al/Ca, Hg concentrations, and quartz/plagioclase. This shift is in the direction of the geochemical signature of sediments from rivers and gold mines in hydraulic mining areas. Mixing calculations using Nd isotopes and concentrations estimate that the hydraulic mining debris comprises up to 56% of the sediment in core sediments deposited during the time of hydraulic mining. The surface sediment of cores taken in 1990 were found to contain up to 43% hydraulic mining debris, reflecting a continuing remobilization and redistribution of the debris within the bay and transport from the watershed. Mercury concentrations in pre

  8. Comparative study between target-controlled-infusion and continuous-infusion anesthesia in dogs treated with methotrimeprazine and treated with propofol and remifentanil Estudo comparativo entre anestesia venosa total alvo-controlada e por infusão contínua em cães pré-tratados com levomepromazina e tratados com propofol e remifentanila

    Directory of Open Access Journals (Sweden)

    Eduardo Hatschbach

    2008-02-01

    Full Text Available PURPOSE: To compare two propofol infusion techniques in bitches subjected to ovaryhisterectomy by estimating the efficiency of the propofol target-dose, evaluating the cardiorespiratory and hemogasimetric attributes, and the bispectral scale index (BIS as well as the recovery period characteristics. METHODS: Twenty anesthetized bitches were divided into two groups of 10 each (G1, G2. Animals of G1 were pre-treated with methotrimeprazine and anesthetized with target-controlled propofol infusion by means of a Harvard infusion pump combined to remifentanil through a syringe pump. RESULTS: Bradycardia and light hypotension, hemogasimetric and respiratory stability besides a good myorelaxation, more evident during continuous infusion and good hypnosis. CONCLUSIONS: Dosis used in both techniques, after methotrimeprazine pre-treatment and combined to the opioid, were efficient for the surgery. The target-controlled anesthesia required a smaller anesthetic consumption (propofol with faster recovery periods.OBJETIVO: Comparar duas técnicas de infusão de propofol em cadelas submetidas à ovariohisterectomia, estudando a eficácia da dose alvo de propofol, avaliando os atributos cardiorrespiratórios, hemogasométricos e escala do índice bispectral, (BIS bem como as características do período de recuperação. MÉTODOS: Foram anestesiadas 20 cadelas, distribuídos em dois grupos (GI e GII. Em GI, os animais foram pré-tratados com levomepromazina e anestesiados com propofol por infusão alvo controlada, através de bomba de infusão Harvard pump, associado com remifentanila, através de bomba de seringa. Em GII, os animais receberam o mesmo tratamento de GI, só que ao invés de receberem o propofol por infusão alvo controlada, receberam o propofol em infusão contínua de velocidade fixa. RESULTADOS: Bradicardia e discreta hipotensão, estabilidade hemogasométrica e respiratória, além de um bom miorrelaxamento, mais evidente na infusão cont

  9. De novo status epilepticus with isolated aphasia.

    Science.gov (United States)

    Flügel, Dominique; Kim, Olaf Chan-Hi; Felbecker, Ansgar; Tettenborn, Barbara

    2015-08-01

    Sudden onset of aphasia is usually due to stroke. Rapid diagnostic workup is necessary if reperfusion therapy is considered. Ictal aphasia is a rare condition but has to be excluded. Perfusion imaging may differentiate acute ischemia from other causes. In dubious cases, EEG is required but is time-consuming and laborious. We report a case where we considered de novo status epilepticus as a cause of aphasia without any lesion even at follow-up. A 62-year-old right-handed woman presented to the emergency department after nurses found her aphasic. She had undergone operative treatment of varicosis 3 days earlier. Apart from hypertension and obesity, no cardiovascular risk factors and no intake of medication other than paracetamol were reported. Neurological examination revealed global aphasia and right pronation in the upper extremity position test. Computed tomography with angiography and perfusion showed no abnormalities. Electroencephalogram performed after the CT scan showed left-sided slowing with high-voltage rhythmic 2/s delta waves but no clear ictal pattern. Intravenous lorazepam did improve EEG slightly, while aphasia did not change. Lumbar puncture was performed which likely excluded encephalitis. Magnetic resonance imaging showed cortical pathological diffusion imaging (restriction) and cortical hyperperfusion in the left parietal region. Intravenous anticonvulsant therapy under continuous EEG resolved neurological symptoms. The patient was kept on anticonvulsant therapy. Magnetic resonance imaging after 6 months showed no abnormalities along with no clinical abnormalities. Magnetic resonance imaging findings were only subtle, and EEG was without clear ictal pattern, so the diagnosis of aphasic status remains with some uncertainty. However, status epilepticus can mimic stroke symptoms and has to be considered in patients with aphasia even when no previous stroke or structural lesions are detectable and EEG shows no epileptic discharges. Epileptic origin is

  10. Biophysical characterization of a de novo elastin

    Science.gov (United States)

    Greenland, Kelly Nicole

    Natural human elastin is found in tissue such as the lungs, arteries, and skin. This protein is formed at birth with no mechanism present to repair or supplement the initial quantity formed. As a result, the functionality and durability of elastin's elasticity is critically important. To date, the mechanics of this ability to stretch and recoil is not fully understood. This study utilizes de novo protein design to create a small library of simplistic versions of elastin-like proteins, demonstrate the elastin-like proteins, maintain elastin's functionality, and inquire into its structure using solution nuclear magnetic resonance (NMR). Elastin is formed from cross-linked tropoelastin. Therefore, the first generation of designed proteins consisted of one protein that utilized homogony of interspecies tropoelastin by using three common domains, two hydrophobic and one cross-linking domains. Basic modifications were made to open the hydrophobic region and also to make the protein easier to purify and characterize. The designed protein maintained its functionality, self-aggregating as the temperature increased. Uniquely, the protein remained self-aggregated as the temperature returned below the critical transition temperature. Self-aggregation was additionally induced by increasing salt concentrations and by modifying the pH. The protein appeared to have little secondary structure when studied with solution NMR. These results fueled a second generation of designed elastin-like proteins. This generation contained variations designed to study the cross-linking domain, one specific hydrophobic domain, and the effect of the length of the elastin-like protein. The cross-linking domain in one variation has been significantly modified while the flanking hydrophobic domains have remained unchanged. This characterization of this protein will answer questions regarding the specificity of the homologous nature of the cross-linking domain of tropoelastin across species. A second

  11. Microbial diversity and carbon cycling in San Francisco Bay wetlands

    Energy Technology Data Exchange (ETDEWEB)

    Theroux, Susanna [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Hartman, Wyatt [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; He, Shaomei [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Univ. of Wisconsin, Madison, WI (United States); Tringe, Susannah [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.

    2014-03-21

    Wetland restoration efforts in San Francisco Bay aim to rebuild habitat for endangered species and provide an effective carbon storage solution, reversing land subsidence caused by a century of industrial and agricultural development. However, the benefits of carbon sequestration may be negated by increased methane production in newly constructed wetlands, making these wetlands net greenhouse gas (GHG) sources to the atmosphere. We investigated the effects of wetland restoration on below-ground microbial communities responsible for GHG cycling in a suite of historic and restored wetlands in SF Bay. Using DNA and RNA sequencing, coupled with real-time GHG monitoring, we profiled the diversity and metabolic potential of wetland soil microbial communities. The wetland soils harbor diverse communities of bacteria and archaea whose membership varies with sampling location, proximity to plant roots and sampling depth. Our results also highlight the dramatic differences in GHG production between historic and restored wetlands and allow us to link microbial community composition and GHG cycling with key environmental variables including salinity, soil carbon and plant species.

  12. San Francisco Biofuel Program: Brown Grease to Biodiesel Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Jolis, Domènec [San Francisco Public Utilities Commission, San Francisco, CA (United States); Martis, Mary [San Francisco Public Utilities Commission, San Francisco, CA (United States); Jones, Bonnie [San Francisco Public Utilities Commission, San Francisco, CA (United States); Miot, Alex [San Francisco Public Utilities Commission, San Francisco, CA (United States); Ving, Karri [San Francisco Public Utilities Commission, San Francisco, CA (United States); Sierra, Natalie [San Francisco Public Utilities Commission, San Francisco, CA (United States); Niobi, Morayo [San Francisco Public Utilities Commission, San Francisco, CA (United States)

    2013-03-01

    Municipal wastewater treatment facilities have typically been limited to the role of accepting wastewater, treating it to required levels, and disposing of its treatment residuals. However, a new view is emerging which includes wastewater treatment facilities as regional resource recovery centers. This view is a direct result of increasingly stringent regulations, concerns over energy use, carbon footprint, and worldwide depletion of fossil fuel resources. Resources in wastewater include chemical and thermal energy, as well as nutrients, and water. A waste stream such as residual grease, which concentrates in the drainage from restaurants (referred to as Trap Waste), is a good example of a resource with an energy content that can be recovered for beneficial reuse. If left in wastewater, grease accumulates inside of the wastewater collection system and can lead to increased corrosion and pipe blockages that can cause wastewater overflows. Also, grease in wastewater that arrives at the treatment facility can impair the operation of preliminary treatment equipment and is only partly removed in the primary treatment process. In addition, residual grease increases the demand in treatment materials such as oxygen in the secondary treatment process. When disposed of in landfills, grease is likely to undergo anaerobic decay prior to landfill capping, resulting in the atmospheric release of methane, a greenhouse gas (GHG). This research project was therefore conceptualized and implemented by the San Francisco Public Utilities Commission (SFPUC) to test the feasibility of energy recovery from Trap Waste in the form of Biodiesel or Methane gas.

  13. Francisco Valles Covarrubias: o galenismo renascentista depois de Andreas Vesalius

    Directory of Open Access Journals (Sweden)

    Madeira, João

    2009-01-01

    Full Text Available Francisco Valles, também conhecido como “El Divino Valles”, foi provavelmente o maior médico espanhol da Renascença e sucedeu a André Vesálio, a quem conheceu pessoalmente, como médico de câmara de Felipe II da Espanha. Formado em Alcalá, deixou inúmeras obras, incluindo o influente Controversiarum medicarum et philosophicarum. A importância da contribuição de Valles para o debate sobre o número, as funções e a localização dos sentidos internos em Aristóteles e em Galeno é atestada pela apreciação que recebeu de Pedro da Fonseca e pela sua relevância para o estudo da história da filosofia e da anatomia, na antiguidade, no Renascimento e na escolástica

  14. La pena de muerte según Francisco de Vitoria

    Directory of Open Access Journals (Sweden)

    Niceto BLÁZQUEZ

    2009-11-01

    Full Text Available Francisco de Vitoria defendió la licitud moral de la pena de muerte como castigo jurídico impuesto por la suprema autoridad del Estado contra determinados delincuentes, lo que plantea un problema serio desde el punto de vista de la defensa de los derechos fundamentales del hombre, entre los cuales hay que destacar el primero y más fundamental, cual es el derecho a la propia vida. El maestro de Salamanca sigue sin ninguna reserva la tesis de Santo Tomás, para cuya defensa añade algunos razonamientos apologéticos sobre los cuales me propongo hacer algunas reflexiones críticas. Vitoria plantea el problema siguiendo el orden riguroso de la Suma Teológica, pero teniendo en cuenta el contexto sociológico, religioso y cultural de su tiempo, lo que le lleva a discutir directamente con protestantes y escotistas, frente a los cuales trata de justificar el pensamiento tomasiano sobre la pena capital por parte del estado.

  15. La potestad tributaria en Francisco Suárez

    Directory of Open Access Journals (Sweden)

    Luis Carlos Amezúa Amezúa

    2017-09-01

    Full Text Available Francisco Suárez es el teólogo más relevante de la escuela española de derecho natural o Escuela de Salamanca en sentido amplio. Según piensa, el derecho de imponer tributos justos reside en exclusiva en la autoridad suprema, sin necesitar el consentimiento de las Cortes. El Estado tiene ese poder de establecer leyes tributarias para asegurar la paz, el orden y el buen gobierno de la comunidad. Es el poder más importante entre todas las facultades propias de la soberanía, pero debe respetar las exigencias de un impuesto justo: además de la autoridad legítima, una causa justa y distribución proporcional. En este artículo, desarrollaremos la doctrina de Suárez, su interpretación acerca de la duda probable sobre la injusticia del impuesto, y su aceptación de los impuestos sobre el consumo. Todos estos razonamientos iban dirigidos a fortalecer al gobernante, que debe actuar dentro de un marco ético respetuoso con el bien común.

  16. São Francisco e os caminhos da pedra

    Directory of Open Access Journals (Sweden)

    Antonio José Faria Góis

    2012-06-01

    Full Text Available A utilização da pedra, no período colonial, limitou-se bastante, em termos locais, à alvenaria e à cantaria, mas também ocorreu seu emprego como material, delimitado, em geral, às obras escultóricas complementares da arquitetura. Uma valorização e ampliação desse limite verificou-se com o lioz, assim como, mais especificamente, em Salvador, com o acréscimo de outros tipos de pedra, igualmente lusitanos e participantes da decoração ambiental. Essa contribuição tem, no conjunto conventual de São Francisco, uma interessante variedade de exemplos, por nós abordada no presente artigo, sendo nosso objetivo indicar dados mais específicos para o exame de um percurso histórico. Partindo do ambiente europeu – não circunscrito à metrópole portuguesa, mas a essa interligado –, tal percurso se reveste do caráter universal que honrosamente nos inclui, dando-nos a oportunidade de avaliar a dimensão cultural e a tradição técnica de obras que enriquecem nosso acervo.

  17. Dried Out: Phytoplankton Drought Response in the San Francisco Estuary

    Science.gov (United States)

    Dawson, T.; Houskeeper, H. F.; Palacios, S. L.; Peacock, M.; Kudela, R. M.

    2017-12-01

    Between 2012 and 2016, the state of California experienced one of the most severe multiyear droughts in nearly 120 years, causing a drastic reduction of freshwater flow to the San Francisco Estuary (SFE). During this period, retention by dams, coupled with the lack of winter rains and spring snow melt led to roughly a third less water reaching the SFE. Decreased freshwater flow to the bay alters the ecology of the SFE, for example by advancing the seasonal timing of phytoplankton blooms, and has been linked to phytoplankton plumes of different, and often more toxic, species. Phytoplankton functional type (PFT) methods, such as PHYDOtax, enable the measurement of community composition, and has been validated in SFE. As part of the NASA Student Airborne Research Program (SARP), we test the accuracy of the PHYDOtax algorithm during the drought period in SFE using matchups between in situ pigment measurements and remotely sensed reflectance spectra from the AVIRIS airborne sensor. We will present time series of salinity and phytoplankton composition in the SFE and evaluate the effects of the drought on the estuarine phytoplankton composition. In the future, California is expected to experience increased frequency of extreme weather events, such as drought, as a consequence of climate change. We evaluate the consequences of the drought on phytoplankton community composition to understand how future extreme weather events may alter the ecology or toxicity of SFE.

  18. Indoor Air Quality Assessment of the San Francisco Federal Building

    Energy Technology Data Exchange (ETDEWEB)

    Apte, Michael; Bennett, Deborah H.; Faulkner, David; Maddalena, Randy L.; Russell, Marion L.; Spears, Michael; Sullivan, Douglas P; Trout, Amber L.

    2008-07-01

    An assessment of the indoor air quality (IAQ) of the San Francisco Federal Building (SFFB) was conducted on May 12 and 14, 2009 at the request of the General Services Administration (GSA). The purpose of the assessment was for a general screening of IAQ parameters typically indicative of well functioning building systems. One naturally ventilated space and one mechanically ventilated space were studied. In both zones, the levels of indoor air contaminants, including CO2, CO, particulate matter, volatile organic compounds, and aldehydes, were low, relative to reference exposure levels and air quality standards for comparable office buildings. We found slightly elevated levels of volatile organic compounds (VOCs) including two compounds often found in"green" cleaning products. In addition, we found two industrial solvents at levels higher than typically seen in office buildings, but the levels were not sufficient to be of a health concern. The ventilation rates in the two study spaces were high by any standard. Ventilation rates in the building should be further investigated and adjusted to be in line with the building design. Based on our measurements, we conclude that the IAQ is satisfactory in the zone we tested, but IAQ may need to be re-checked after the ventilation rates have been lowered.

  19. Los diálogos lucianescos de Francisco Sobrino

    Directory of Open Access Journals (Sweden)

    Nieves Arribas

    2010-12-01

    Full Text Available En 1708, el impresor François Foppens publica en Bruselas los Dialogues Nouveaux [...] de Francisco Sobrino, un oficial reformado y maestro de Corte que plagia, incrementándola, la colección de César Oudin (Dialogos muy apazibles [...] Marc Orry, 1608, quien a su vez había hecho lo propio con los siete de John Minsheu (Pleasant and Delightfull Dialogues, Londres, 1599 en una de la líneas editoriales más importantes, paralela a la de otras constelaciones (como la inaugurada por Noel de Berlaimont de la riquísima tradición paneuropea de coloquios didácticos creados para dar muestras de conversacionalidad a quienes desearan aprender segundas lenguas. De los seis diálogos originales de Sobrino, cuatro son fantasiosos y de éstos, hay tres lucianescos en el sentido de que usan la ‘estrategia de Luciano’ pues sus interlocutores son personajes muertos (Mahoma, Colón, Moctezuma, etc.. Será trazado aquí un análisis de las características de los mismos, con especial atención a los componentes didácticos e ideológicos.

  20. Steam, solarization, and tons of prevention: the San Francisco Public Utilities Commission's fight to contain Phytophthoras in San Francisco Bay area restoration sites

    Science.gov (United States)

    Greg Lyman; Jessica Appel; Mia Ingolia; Ellen Natesan; Joe Ortiz

    2017-01-01

    To compensate for unavoidable impacts associated with critical water infrastructure capital improvement projects, the San Francisco Public Utilities Commission (SFPUC) restored over 2,050 acres of riparian, wetland, and upland habitat on watershed lands in Alameda, Santa Clara, and San Mateo Counties. Despite strict bio-sanitation protocols, plant pathogens (...

  1. Constrained De Novo Sequencing of Peptides with Application to Conotoxins

    Science.gov (United States)

    Bhatia, Swapnil; Kil, Yong J.; Ueberheide, Beatrix; Chait, Brian; Tayo, Lemmuel L.; Cruz, Lourdes J.; Lu, Bingwen; Yates, John R.; Bern, Marshall

    We describe algorithms for incorporating prior sequence knowledge into the candidate generation stage of de novo peptide sequencing by tandem mass spectrometry. We focus on two types of prior knowledge: homology to known sequences encoded by a regular expression or position-specific score matrix, and amino acid content encoded by a multiset of required residues. We show an application to de novo sequencing of cone snail toxins, which are molecules of special interest as pharmaceutical leads and as probes to study ion channels. Cone snail toxins usually contain 2, 4, 6, or 8 cysteine residues, and the number of residues can be determined by a relatively simple mass spectrometry experiment. We show here that the prior knowledge of the number of cysteines in a precursor ion is highly advantageous for de novo sequencing.

  2. RAMPART: a workflow management system for de novo genome assembly.

    Science.gov (United States)

    Mapleson, Daniel; Drou, Nizar; Swarbreck, David

    2015-06-01

    The de novo assembly of genomes from whole- genome shotgun sequence data is a computationally intensive, multi-stage task and it is not known a priori which methods and parameter settings will produce optimal results. In current de novo assembly projects, a popular strategy involves trying many approaches, using different tools and settings, and then comparing and contrasting the results in order to select a final assembly for publication. Herein, we present RAMPART, a configurable workflow management system for de novo genome assembly, which helps the user identify combinations of third-party tools and settings that provide good results for their particular genome and sequenced reads. RAMPART is designed to exploit High performance computing environments, such as clusters and shared memory systems, where available. RAMPART is available under the GPLv3 license at: https://github.com/TGAC/RAMPART. © The Author 2015. Published by Oxford University Press.

  3. Pathway design using de novo steps through uncharted biochemical spaces.

    Science.gov (United States)

    Kumar, Akhil; Wang, Lin; Ng, Chiam Yu; Maranas, Costas D

    2018-01-12

    Existing retrosynthesis tools generally traverse production routes from a source to a sink metabolite using known enzymes or de novo steps. Generally, important considerations such as blending known transformations with putative steps, complexity of pathway topology, mass conservation, cofactor balance, thermodynamic feasibility, microbial chassis selection, and cost are largely dealt with in a posteriori fashion. The computational procedure we present here designs bioconversion routes while simultaneously considering any combination of the aforementioned design criteria. First, we track and codify as rules all reaction centers using a prime factorization-based encoding technique (rePrime). Reaction rules and known biotransformations are then simultaneously used by the pathway design algorithm (novoStoic) to trace both metabolites and molecular moieties through balanced bio-conversion strategies. We demonstrate the use of novoStoic in bypassing steps in existing pathways through putative transformations, assembling complex pathways blending both known and putative steps toward pharmaceuticals, and postulating ways to biodegrade xenobiotics.

  4. Canvas SPW: calling de novo copy number variants in pedigrees.

    Science.gov (United States)

    Ivakhno, Sergii; Roller, Eric; Colombo, Camilla; Tedder, Philip; Cox, Anthony J

    2018-02-01

    Whole genome sequencing is becoming a diagnostics of choice for the identification of rare inherited and de novo copy number variants in families with various pediatric and late-onset genetic diseases. However, joint variant calling in pedigrees is hampered by the complexity of consensus breakpoint alignment across samples within an arbitrary pedigree structure. We have developed a new tool, Canvas SPW, for the identification of inherited and de novo copy number variants from pedigree sequencing data. Canvas SPW supports a number of family structures and provides a wide range of scoring and filtering options to automate and streamline identification of de novo variants. Canvas SPW is available for download from https://github.com/Illumina/canvas. sivakhno@illumina.com. Supplementary data are available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  5. Preferência manual na ação de alcançar em bebês em função da localização espacial do alvo Infants' manual preference in reaching regarding spatial target location

    Directory of Open Access Journals (Sweden)

    Rosana Machado Souza

    2011-01-01

    Full Text Available Preferência manual em bebês de 5 meses de idade foi avaliada em tarefas de alcançar alvos estáticos posicionados na linha média, à direita e à esquerda com referência a coordenadas egocêntricas. A análise da frequência de uso das mãos indicou direção e magnitude de preferência manual diversificadas entre os bebês. Foi observado que os bebês realizaram predominantemente alcances ipsilaterais para alvos posicionados lateralmente. Para alcances na linha média a frequência de uso foi semelhante entre as mãos direita e esquerda. Os resultados sugerem que nessa fase do desenvolvimento a preferência manual para o alcançar é alterada pela posição dos objetos no espaço.Manual preference of 5-month-old infants was evaluated in tasks of reaching static targets positioned on the midline, at the left and right, regarding egocentric coordinates. Frequency analysis of using the hands pointed out to diversified direction and magnitude of manual preference among infants. It was observed that they predominantly made ipsilateral reaches toward targets laterally positioned. Frequency of using the right and left hands was similar for targets located at the midline. The results suggest that in this stage of development manual preference is shifted by the spatial position of the objects.

  6. Oferta de projetos sociais e a ação das crianças: a construção de uma experiência de infância público-alvo = The offer of social projects and children’s actions: childhood experience and the construction of a “target population”

    Directory of Open Access Journals (Sweden)

    Thomassim, Luís Eduardo

    2013-01-01

    Full Text Available Este artigo propõe-se a refletir sobre as relações envolvidas na oferta de projetos sociais e na participação dos sujeitos para os quais são destinados. O ponto de partida do texto é analisar como se “constroem” os públicos destes projetos, questão que emergiu durante uma pesquisa de doutorado cuja atenção voltou-se para compreender como o público-alvo se relaciona com a oferta destas programações. O estudo foi desenvolvido através de uma pesquisa etnográfica numa vila popular de Porto Alegre. Assumiu-se que os sentidos dos projetos sociais resultam das relações que os envolvem situacionalmente e que os significados destes são construídos também pelas experiências das populações atendidas em suas programações. O artigo defende que, muito antes de uma equação envolvendo mera oferta e demanda, a construção dos públicos destas programações é uma relação. Para viabilizar esta análise, descreve-se procedimentos institucionais para “recrutar” públicos e também condutas do público-alvo diante destas programações

  7. Convocando os hermeneutas da república iletrada: o prêmio Francisco Alves - Gathering the hermenauts of illiterate’s republic: the prize Francisco Alves

    Directory of Open Access Journals (Sweden)

    Carlos Roberto da Silva Monarcha, Brasil

    2014-09-01

    Full Text Available Este artigo apresenta resultados de estudos e pesquisas centrados no Prêmio Francisco Alves, instituído pela Academia Brasileira de Letras sob a denominação de O melhor meio de disseminar o ensino primário no Brasil. A pesquisa básica localizou, recuperou e analisou inúmeros artigos e notas publicados na Revista da Academia Brasileira de Letras e, posteriormente, monografias premiadas de intelectuais expressivos: Marques Pinheiro, Jorge Augusto Büchler, Pedro Deodato de Moraes, Achilles Lisboa, Manoel Bomfim e Sud Mennucci. Conclui-se que, durante a sua vigência, o Prêmio Francisco Alves funcionou como convocatória quinquenal dos intelectuais dispostos a pensar e dar a conhecer as possibilidades de outro futuro para o Brasil, pela via da instrução popular disseminada.  Palavras-chave: prêmio Francisco Alves, Academia Brasileira de Letras, escola elementar, instrução popular.GATHERING THE HERMENAUTS OF ILLITERATE’S REPUBLIC: THE PRIZE FRANCISCO ALVESAbstractThis article presents results of studies and researches focused in the Prize Francisco Alves, instituted by Academia Brasileira de Letras under the name The best way to disseminate primary education in Brazil, besides it addresses the origin and trajectory of the prize. The basic research found, recovered, and analyzed several articles and notes published in Revista da Academia Brasileira de Letras and, posteriorly, different prizewinning monographs, of several expressive intellectuals: Marques Pinheiro, Jorge Augusto Büchler, Pedro Deodato de Moraes, Achilles Lisboa, Manoel Bomfim, and Sud Mennucci. It concludes that, during its terms, the prize Francisco Alves worked as a quinquennial call for the intellectuals willing to think and know the possibilities of another future for Brazil, via dissemination of popular instruction.Key-words: Prize Francisco Alves, Brazilian Academy of Letters, elementary school, popular instruction.CONVOCANDO A LOS HERMENÉUTICOS DE LA REP

  8. As “marcas” de uma nova fronteira vinícola: identidade cultural das marcas de vinhos do Vale do São Francisco [doi: 10.5329/RECADM.2014025

    Directory of Open Access Journals (Sweden)

    Suélen Matozo Franco

    2014-12-01

    Full Text Available O polo vitivinícola Vale do São Francisco situa-se no Novo Mundo dos vinhos, onde o desenvolvimento das marcas é a orientação dominante. Assim, a identidade desses vinhos está atrelada à de suas marcas. A identidade marcária, discutida tradicionalmente sob uma orientação estratégico-gerencial, também pode ser concebida como identidade discursiva, resultante de diversos vetores além de formulações estratégicas. Aqui, de forma propositiva, assumimos a identidade de marcas como resultado de processos identificatórios numa cultura, portanto uma identidade cultural, o que se aproxima da concepção discursiva. Buscamos, portanto, compreender como são construídas as identidades das marcas de vinho do Vale do São Francisco. Para tanto, procedemos a uma análise de discurso crítica, com base na Linguística Sistêmico-Funcional de M. A. K. Halliday, de entrevistas realizadas com três grupos de agentes: produtores, consumidores e mediadores. Chegamos a 20 traços identitários, que, agrupados conceitualmente, resultaram em seis identidades culturais: acanhada, competente, jovial, honesta, medíocre e tradicional. Os resultados apontam para uma construção de identidades ancorada num sistema de referências dominante, resultando na desconsideração da tipicidade da região, numa tentativa de sufocar a diferença e alinhar-se ao discurso dominante.. Palavras-Chave Vale do São Francisco, Identidade, Marca, Linguística Sistêmico-Funcional.     “BRANDS” OF A NEW WINERY FRONTIER: SÃO FRANCISCO VALLEY WINE BRANDS’ CULTURAL IDENTITY   ABSTRACT The São Francisco Valley is located in wine’s New World, where the development of brands is the dominant orientation. Thus, the identity of these wines is linked to their brands. The identity mark, traditionally discussed a policy-strategic management, can also be conceived as discursive identity resulting from various vectors as well as strategic formulations. Here, in a purposeful

  9. Edificio para ambulatorio San Francisco – (EE. UU.

    Directory of Open Access Journals (Sweden)

    Reid, John Lyon

    1976-12-01

    Full Text Available The 50,470 m2 the total area of the hospital is distributed as follows: 18,900 m2 for the 22 main clinics and for the additional clinics; 2,770 m2 for complementary activities; and the remaining 28,800 m2 for a parking lot with space for 700 cars. The building occupies a site that slopes strongly towards the north across which runs the pedestrian access from one of the circumference roads to the main façade; the access road for the vehicles leads to the back facade, where the natural slope of the ground has been taken advantage of to build the 5 storey parking building. The two main functions —the clinics and the parking house— are conveniently separated though connected with each other by means of corridors and lifts. The interior design of the clinics is very flexible so as to allow for further enlargements. The patients' waiting rooms are provided with a glazed façade and have a beautiful view over the San Francisco Bay and its surroundings. The construction is entirely of concrete and its structure is calculated ín such a manner as to allow for two additional storeys.Cuenta con una superficie total construida de 50.470 m2, repartidos de la siguiente forma: 18.900 se destinan a la distribución de 22 clínicas principales y otras secundarias; 2.770 a locales de actividades complementarias; y el resto, 28.800 m2, a aparcamiento con capacidad para 700 plazas. El edificio ocupa una parcela fuertemente inclinada hacia el norte, inclinación que permite el acceso peatonal a la clínica, por la fachada principal, desde una de las avenidas perimetrales; y el vehicular, por la fachada posterior, en donde, aprovechando el desnivel del terreno, se han organizado las cinco plantas del aparcamiento. Las dos funciones principales —clínicas y aparcamiento— se hallan convenientemente separadas, estableciéndose el enlace entre los distintos niveles mediante ascensores que relacionan las clínicas, el centro médico, los aparcamientos

  10. Psychiatric disorders and substance use in homeless youth: a preliminary comparison of san francisco and chicago.

    Science.gov (United States)

    Quimby, Ernika G; Edidin, Jennifer P; Ganim, Zoe; Gustafson, Erika; Hunter, Scott J; Karnik, Niranjan S

    2012-09-01

    Youth homelessness is a growing problem in the United States. The experience of homelessness appears to have numerous adverse consequences, including psychiatric and substance use disorders. This study compared the frequencies of psychiatric disorders, including substance use, between homeless youth (18-24 years-old) in San Francisco (N = 31) and Chicago (N = 56). Subjects were administered the Mini International Neuropsychiatric Interview (M.I.N.I.) to assess DSM-IV-TR diagnoses and substance use disorders. Eighty-seven percent of the San Francisco youth, and 81% of the Chicago youth met criteria for at least one M.I.N.I. psychiatric diagnosis. Nearly two-thirds of the youth in both samples met criteria for a mood disorder. Approximately one-third met criteria for an anxiety disorder. Thirty-two percent of the San Francisco sample and 18% of the Chicago met criteria for Antisocial Personality Disorder. Approximately 84% of the San Francisco youth and 48% of the Chicago youth met criteria for a substance-related disorder, and more substances were used by San Francisco youth. In conclusion, the high rate of psychiatric disorders in homeless youth provides clear evidence that the mental health needs of this population are significant. Implications are discussed.

  11. Psychiatric Disorders and Substance Use in Homeless Youth: A Preliminary Comparison of San Francisco and Chicago

    Directory of Open Access Journals (Sweden)

    Ernika G. Quimby

    2012-08-01

    Full Text Available Youth homelessness is a growing problem in the United States. The experience of homelessness appears to have numerous adverse consequences, including psychiatric and substance use disorders. This study compared the frequencies of psychiatric disorders, including substance use, between homeless youth (18–24 years-old in San Francisco (N = 31 and Chicago (N = 56. Subjects were administered the Mini International Neuropsychiatric Interview (M.I.N.I. to assess DSM-IV-TR diagnoses and substance use disorders. Eighty-seven percent of the San Francisco youth, and 81% of the Chicago youth met criteria for at least one M.I.N.I. psychiatric diagnosis. Nearly two-thirds of the youth in both samples met criteria for a mood disorder. Approximately one-third met criteria for an anxiety disorder. Thirty-two percent of the San Francisco sample and 18% of the Chicago met criteria for Antisocial Personality Disorder. Approximately 84% of the San Francisco youth and 48% of the Chicago youth met criteria for a substance-related disorder, and more substances were used by San Francisco youth. In conclusion, the high rate of psychiatric disorders in homeless youth provides clear evidence that the mental health needs of this population are significant. Implications are discussed.

  12. Habitat Variability and Complexity in the Upper San Francisco Estuary

    Directory of Open Access Journals (Sweden)

    Peter B Moyle

    2010-09-01

    Full Text Available High variability in environmental conditions in both space and time once made the upper San Francisco Estuary (the Estuary highly productive for native biota. Present conditions often discourage native species, providing a rationale for restoring estuarine variability and habitat complexity. Achieving a variable, more complex Estuary requires policies which: (1 establish internal Sacramento–San Joaquin Delta (the Delta flows that create a tidally mixed, upstream–downstream gradient in water quality, with minimal cross-Delta flows; (2 create slough networks with more natural channel geometry and less diked, riprapped channel habitat; (3 increase inflows from the Sacramento and San Joaquin rivers; (4 increase tidal marsh habitat, including shallow (1 to 2 m subtidal areas, in both fresh and brackish zones of the Estuary; (5 create/allow large expanses of low salinity (1 to 4 ppt open water habitat in the Delta; (6 create a hydrodynamic regime where salinities in the upper Estuary range from near-fresh to 8 to 10 ppt periodically, to discourage alien species and favor desirable species; (7 take species-specific actions that reduce abundance of non-native species and increase abundance of desirable species; (8 establish abundant annual floodplain habitat, with additional large areas that flood in less frequent wet years; (9 reduce inflow of agricultural and urban pollutants; and (10 improve the temperature regime in large areas of the Estuary so temperatures rarely exceed 20 °C during summer and fall months. These actions collectively provide a realistic if experimental approach to achieving flow and habitat objectives to benefit desirable species. Some of these goals are likely to be achieved without deliberate action as the result of sea level rise, climate change, and levee failures, but in the near term, habitat, flow restoration and export reduction projects can enhance a return to a more variable and more productive ecosystem.

  13. Regional Air Toxics Modeling in California's San Francisco Bay Area

    Science.gov (United States)

    Martien, P. T.; Tanrikulu, S.; Tran, C.; Fairley, D.; Jia, Y.; Fanai, A.; Reid, S.; Yarwood, G.; Emery, C.

    2011-12-01

    Regional toxics modeling conducted for California's San Francisco Bay Area (SFBA) estimated potential cancer risk from diesel particulate matter (DPM) and four key reactive toxic gaseous pollutants (1,3-butadiene, benzene, formaldehyde, and acetaldehyde). Concentrations of other non-cancerous gaseous toxic air contaminants, including acrolein, were also generated. In this study, meteorological fields generated from July and December periods in 2000 and emissions from 2005 provided inputs to a three-dimensional air quality model at high spatial resolution (1x1 km^2 grid), from which a baseline set of annual risk values was estimated. Simulated risk maps show highest annual average DPM concentrations and cancer risks were located near and downwind of major freeways and near the Port of Oakland, a major container port in the area. Population weighted risks, using 2000 census data, were found to be highest in highly urbanized areas adjacent to significant DPM sources. For summer, the ratio of mean measured elemental carbon to mean modeled DPM was 0.78, conforming roughly to expectations. But for winter the ratio is 1.13, suggesting other sources of elemental carbon, such as wood smoke, are important. Simulated annual estimates for benzene and 1-3, butadiene compared well to measured annual estimates. Simulated acrolein and formaldehyde significantly under-predicted observed values. Simulations repeated using projected 2015 toxic emissions predicted that potential cancer risk dropped significantly in all areas throughout the SFBA. Emissions estimates for 2015 included the State of California's recently adopted on-road truck rule. Emission estimates of DPM are projected to drop about 70% between 2005 and 2015 in the SFBA, with a commensurate reduction in potential cancer risks. However, due to projected shifts in population during this period, with urban densification close to DPM sources outpacing emission reductions, there are some areas where population-weighted risks

  14. A Summary of the San Francisco Tidal Wetlands Restoration Series

    Directory of Open Access Journals (Sweden)

    Larry R. Brown

    2003-10-01

    Full Text Available The four topical articles of the Tidal Wetlands Restoration Series summarized and synthesized much of what is known about tidal wetlands and tidal wetland restoration in the San Francisco Estuary (hereafter “Estuary”. Despite a substantial amount of available information, major uncertainties remain. A major uncertainty with regard to fishes is the net benefit of restored tidal wetlands relative to other habitats for native fishes in different regions of the Estuary given the presence of numerous invasive alien species. With regard to organic carbon, a major uncertainty is the net benefit of land use change given uncertainty about the quantity and quality of different forms of organic carbon resulting from different land uses. A major challenge is determining the flux of organic carbon from open systems like tidal wetlands. Converting present land uses to tidal wetlands will almost certainly result in increased methylation of mercury at the local scale with associated accumulation of mercury within local food webs. However, it is unclear if such local accumulation is of concern for fish, wildlife or humans at the local scale or if cumulative effects at the regional scale will emerge. Based on available information it is expected that restored tidal wetlands will remain stable once constructed; however, there is uncertainty associated with the available data regarding the balance of sediment accretion, sea-level rise, and sediment erosion. There is also uncertainty regarding the cumulative effect of many tidal restoration projects on sediment supply. The conclusions of the articles highlight the need to adopt a regional and multidisciplinary approach to tidal wetland restoration in the Estuary. The Science Program of the CALFED effort provides an appropriate venue for addressing these issues.

  15. No ritmo do Vagalume: culturas negras, associativismo dançante e nacionalidade na produção de Francisco Guimarães (1904-1933

    Directory of Open Access Journals (Sweden)

    Leonardo Affonso de Miranda Pereira

    2015-06-01

    Full Text Available Francisco Guimarães, o Vagalume, foi um dos mais populares cronistas e dramaturgos no Rio de Janeiro da Primeira República. Reconhecido pela posteridade pela publicação do livro Na roda do samba, de 1933, nasceu na segunda metade da década de 1870 em uma família de trabalhadores negros. Foi por isso um dos muitos afrodescendentes que, no pós-abolição, tiveram de buscar novos caminhos de sobrevivência e afirmação profissional. Vagalume o fez através de uma produção explicitamente vinculada aos interesses e à linguagem dos trabalhadores negros e mestiços da cidade, cujas práticas dançantes e carnavalescas sempre buscou registrar. Com base em sua trajetória, o artigo se propõe investigar como Vagalume ajudou a definir novas bases para a cultura carioca e brasileira ao longo da Primeira República - em processo que teve na afirmação do samba como ritmo nacional seu resultado mais visível.

  16. Risk factors for de novo hepatitis B infection in pediatric living donor liver transplantation

    OpenAIRE

    Rao, Wei; Xie, Man; Yang, Tao; Zhang, Jian-Jun; Gao, Wei; Deng, Yong-Lin; Zheng, Hong; Pan, Cheng; Liu, Yi-He; Shen, Zhong-Yang

    2014-01-01

    AIM: To investigate the incidence of de novo hepatitis B virus (HBV) infection after pediatric living donor liver transplantation (LDLT) and to analyze the risk factors associated with this de novo HBV infection.

  17. Characteristics of de novo structural changes in the human genome

    NARCIS (Netherlands)

    Kloosterman, Wigard P.; Francioli, Laurent C.; Hormozdiari, Fereydoun; Marschall, Tobias; Hehir-Kwa, Jayne Y.; Abdellaoui, Abdel; Lameijer, Eric-Wubbo; Moed, Matthijs H.; Koval, Vyacheslav; Renkens, Ivo; van Roosmalen, Markus J.; Arp, Pascal; Karssen, Lennart C.; Coe, Bradley P.; Handsaker, Robert E.; Suchiman, Eka D.; Cuppen, Edwin; Thung, Djie Tjwan; McVey, Mitch; Wendl, Michael C.; Uitterlinden, Andre; van Duijn, Cornelia M.; Swertz, Morris A.; Wijmenga, Cisca; van Ommen, GertJan B.; Slagboom, P. Eline; Boomsma, Dorret I.; Schoenhuth, Alexander; Eichler, Evan E.; de Bakker, Paul I. W.; Ye, Kai; Guryev, Victor

    Small insertions and deletions (indels) and large structural variations (SVs) are major contributors to human genetic diversity and disease. However, mutation rates and characteristics of de novo indels and SVs in the general population have remained largely unexplored. We report 332 validated de

  18. De novo structural modeling and computational sequence analysis ...

    African Journals Online (AJOL)

    Jane

    2011-07-25

    Jul 25, 2011 ... Our study was aimed towards computational proteomic analysis and 3D structural modeling of this novel bacteriocin protein encoded by the earlier aforementioned gene. Different bioinformatics tools and machine learning techniques were used for protein structural classification. De novo protein modeling ...

  19. De novo autoimmune hepatitis following liver transplantation for ...

    African Journals Online (AJOL)

    De novo autoimmune hepatitis (AIH) is a rare disorder first described in 1998. It occurs in patients who underwent liver transplantation for a different etiology. We present the case of a 56-year-old woman who was diagnosed with primary biliary cirrhosis and had liver transplantation for refractory pruritis. Seven years after ...

  20. Response monitoring in de novo patients with Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Rita Willemssen

    Full Text Available BACKGROUND: Parkinson's disease (PD is accompanied by dysfunctions in a variety of cognitive processes. One of these is error processing, which depends upon phasic decreases of medial prefrontal dopaminergic activity. Until now, there is no study evaluating these processes in newly diagnosed, untreated patients with PD ("de novo PD". METHODOLOGY/PRINCIPAL FINDINGS: Here we report large changes in performance monitoring processes using event-related potentials (ERPs in de novo PD-patients. The results suggest that increases in medial frontal dopaminergic activity after an error (Ne are decreased, relative to age-matched controls. In contrast, neurophysiological processes reflecting general motor response monitoring (Nc are enhanced in de novo patients. CONCLUSIONS/SIGNIFICANCE: It may be hypothesized that the Nc-increase is at costs of dopaminergic activity after an error; on a functional level errors may not always be detected and correct responses sometimes be misinterpreted as errors. This pattern differs from studies examining patients with a longer history of PD and may reflect compensatory processes, frequently occurring in pre-manifest stages of PD. From a clinical point of view the clearly attenuated Ne in the de novo PD patients may prove a useful additional tool for the early diagnosis of basal ganglia dysfunction in PD.

  1. Model-Based GUI Testing Using Uppaal at Novo Nordisk

    DEFF Research Database (Denmark)

    H. Hjort, Ulrik; Rasmussen, Jacob Illum; Larsen, Kim Guldstrand

    2009-01-01

    This paper details a collaboration between Aalborg University and Novo Nordiskin developing an automatic model-based test generation tool for system testing of the graphical user interface of a medical device on an embedded platform. The tool takes as input an UML Statemachine model and generates...

  2. Towards accurate de novo assembly for genomes with repeats

    NARCIS (Netherlands)

    Bucur, Doina

    2017-01-01

    De novo genome assemblers designed for short k-mer length or using short raw reads are unlikely to recover complex features of the underlying genome, such as repeats hundreds of bases long. We implement a stochastic machine-learning method which obtains accurate assemblies with repeats and

  3. De novo structural modeling and computational sequence analysis ...

    African Journals Online (AJOL)

    Different bioinformatics tools and machine learning techniques were used for protein structural classification. De novo protein modeling was performed by using I-TASSER server. The final model obtained was accessed by PROCHECK and DFIRE2, which confirmed that the final model is reliable. Until complete biochemical ...

  4. Peptide de novo sequencing of mixture tandem mass spectra

    DEFF Research Database (Denmark)

    Gorshkov, Vladimir; Hotta, Stéphanie Yuki Kolbeck; Braga, Thiago Verano

    2016-01-01

    The impact of mixture spectra deconvolution on the performance of four popular de novo sequencing programs was tested using artificially constructed mixture spectra as well as experimental proteomics data. Mixture fragmentation spectra are recognized as a limitation in proteomics because they dec...

  5. De Novo Coding Variants Are Strongly Associated with Tourette Disorder

    NARCIS (Netherlands)

    Willsey, A. Jeremy; Fernandez, Thomas V.; Yu, Dongmei; King, Robert A.; Dietrich, Andrea; Xing, Jinchuan; Sanders, Stephan J.; Mandell, Jeffrey D.; Huang, Alden Y.; Richer, Petra; Smith, Louw; Dong, Shan; Samocha, Kaitlin E.; Neale, Benjamin M.; Coppola, Giovanni; Mathews, Carol A.; Tischfield, Jay A.; Scharf, Jeremiah M.; State, Matthew W.; Heiman, Gary A.; Abdulkadir, Mohamed; Bohnenpoll, Julia; Bromberg, Yana; Brown, Lawrence W.; Cheon, Keun-Ah; Coffey, Barbara J.; Deng, Li; Elzerman, Lonneke; Fründt, Odette; Garcia-Delgar, Blanca; Gedvilaite, Erika; Gilbert, Donald L.; Grice, Dorothy E.; Hagstrøm, Julie; Hedderly, Tammy; Heyman, Isobel; Hoekstra, Pieter J.; Hong, Hyun Ju; Huyser, Chaim; Ibanez-Gomez, Laura; Kim, Young Key; Kim, Young-Shin; Koh, Yun-Joo; Kook, Sodahm; Kuperman, Samuel; Lamerz, Andreas; Leventhal, Bennett; Ludolph, Andrea G.; Lühr da Silva, Claudia; Madruga-Garrido, Marcos; Maras, Athanasios; Mir, Pablo; Morer, Astrid; Münchau, Alexander; Murphy, Tara L.; Nasello, Cara; Openneer, Thaïra J. C.; Plessen, Kerstin J.; Roessner, Veit; Sanders, Stephan; Shin, Eun-Young; Sival, Deborah A.; Song, Dong-Ho; Song, Jungeun; Stolte, Anne Marie; Sun, Nawei; Tübing, Jennifer; Visscher, Frank; Walker, Michael F.; Wanderer, Sina; Wang, Shuoguo; Woods, Martin; Zhang, Yeting; Zhou, Anbo; Zinner, Samuel H.; Barr, Cathy L.; Batterson, James R.; Berlin, Cheston; Bruun, Ruth D.; Budman, Cathy L.; Cath, Danielle C.; Chouinard, Sylvain; Cox, Nancy J.; Darrow, Sabrina; Davis, Lea K.; Dion, Yves; Freimer, Nelson B.; Grados, Marco A.; Hirschtritt, Matthew E.; Illmann, Cornelia; Kurlan, Roger; Leckman, James F.; Lyon, Gholson J.; Malaty, Irene A.; MaMahon, William M.; Okun, Michael S.; Osiecki, Lisa; Pauls, David L.; Posthuma, Danielle; Ramensky, Vasily; Robertson, Mary M.; Rouleau, Guy A.; Sandor, Paul; Singer, Harvey S.; Smit, Jan; Sul, Jae-Hoon

    2017-01-01

    Whole-exome sequencing (WES) and de novo variant detection have proven a powerful approach to gene discovery in complex neurodevelopmental disorders. We have completed WES of 325 Tourette disorder trios from the Tourette International Collaborative Genetics cohort and a replication sample of 186

  6. Illumina-based de novo transcriptome sequencing and analysis of ...

    Indian Academy of Sciences (India)

    2017-12-18

    Dec 18, 2017 ... In the present study, we used Illumina HiSeq technology to perform de novo assembly of heart and musk gland transcriptomes from the Chinese forest musk deer. A total of 239,383 transcripts and 176,450 unigenes were obtained, of which 37,329 unigenes were matched to known sequences in the NCBI ...

  7. Automated de novo metabolite identification with mass spectrometry and cheminformatics

    NARCIS (Netherlands)

    Peironcely Miguel, Julio Eduardo

    2014-01-01

    In this thesis new algorithms and methods that enable the de novo identification of metabolites have been developed. The aim was to find methods to propose candidate structures for unknown metabolites using MSn data as starting point. These methods have been integrated into a semi-automated pipeline

  8. Identifying wrong assemblies in de novo short read primary ...

    Indian Academy of Sciences (India)

    2016-08-05

    Aug 5, 2016 ... With the advent of short-reads-based genome sequencing approaches, large number of organisms are being sequenced all over the world. Most of these assemblies are done using some de novo short read assemblers and other related approaches. However, the contigs produced this way are prone to ...

  9. De novo peroxisome biogenesis: Evolving concepts and conundrums.

    Science.gov (United States)

    Agrawal, Gaurav; Subramani, Suresh

    2016-05-01

    Peroxisomes proliferate by growth and division of pre-existing peroxisomes or could arise de novo. Though the de novo pathway of peroxisome biogenesis is a more recent discovery, several studies have highlighted key mechanistic details of the pathway. The endoplasmic reticulum (ER) is the primary source of lipids and proteins for the newly-formed peroxisomes. More recently, an intricate sorting process functioning at the ER has been proposed, that segregates specific PMPs first to peroxisome-specific ER domains (pER) and then assembles PMPs selectively into distinct pre-peroxisomal vesicles (ppVs) that later fuse to form import-competent peroxisomes. In addition, plausible roles of the three key peroxins Pex3, Pex16 and Pex19, which are also central to the growth and division pathway, have been suggested in the de novo process. In this review, we discuss key developments and highlight the unexplored avenues in de novo peroxisome biogenesis. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Control of Cell Fate Reprogramming Towards De Novo Shoot Organogenesis.

    Science.gov (United States)

    Tian, Xin; Zhang, Chen; Xu, Jian

    2017-12-23

    Many plants have a high regenerative capacity, which can be used to induce de novo organogenesis and produce various valuable plant species and products. In the classic 2-step protocol for de novo shoot organogenesis, small pieces of plant parts or tissues known as explants are initially cultured on an auxin-rich medium to produce a cell mass called callus. Upon transfer to a cytokinin-rich medium, a subpopulation of cells within the callus acquire shoot cell fate and subsequently develop into a fertile shoot. Cell fate reprogramming during de novo organogenesis is thus recognized as the decisive step to progressively acquire new cell types, in response to a change in the levels of plant hormones auxin and cytokinin. Currently, the molecular mechanisms underlying the onset and completion of cell fate reprogramming remains partly understood. In this review, we sought to summarize the most recent progress made in the study of cell fate reprogramming during de novo shoot organogenesis, and highlight the critical roles of epigenetic and transcription factors in the developmental timing of cell fate reprogramming. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  11. Illumina-based de novo transcriptome sequencing and analysis

    Indian Academy of Sciences (India)

    In the present study, we used Illumina HiSeq technology to perform de novo assembly of heart and musk gland transcriptomes from the Chinese forest musk deer. A total of 239,383 transcripts and 176,450 unigenes were obtained, of which 37,329 unigenes were matched to known sequences in the NCBI nonredundant ...

  12. Engineering and introduction of de novo disulphide bridges in ...

    Indian Academy of Sciences (India)

    The engineeringof de novo disulphide bridges has been explored as a means to increase the thermal stability of enzymes in the rationalmethod of protein engineering. In this study, Disulphide by Design software, homology modelling and moleculardynamics simulations were used to select appropriate amino acid pairs for ...

  13. TUBB4A de novo mutations cause isolated hypomyelination

    NARCIS (Netherlands)

    Pizzino, Amy; Pierson, Tyler Mark; Guo, Yiran; Helman, Guy; Fortini, Sebastian; Guerrero, Kether; Saitta, Sulagna; Murphy, Jennifer Louise Patrick; Padiath, Quasar; Xie, Yi; Hakonarson, Hakon; Xu, Xun; Funari, Tara; Fox, Michelle; Taft, Ryan J.; van der Knaap, Marjo S.; Bernard, Geneviève; Schiffmann, Raphael; Simons, Cas; Vanderver, Adeline

    2014-01-01

    We present a series of unrelated patients with isolated hypomyelination, with or without mild cerebellar atrophy, and de novo TUBB4A mutations. Patients in 2 large institutional review board-approved leukodystrophy bioregistries at Children's National Medical Center and Montreal Children's Hospital

  14. Cardiovascular dysautonomia in de novo Parkinson's disease without orthostatic hypotension.

    Science.gov (United States)

    Oka, H; Toyoda, C; Yogo, M; Mochio, S

    2011-02-01

    Clinical symptoms of Parkinson's disease (PD) include not only motor distress, but also autonomic dysfunction. To study the characteristics of subclinical autonomic nervous dysfunction in de novo PD without orthostatic hypotension (OH). Autonomic nervous function including cardiac sympathetic gain was evaluated on the basis of cardiac radioiodinated metaiodobenzylguanidine (MIBG) uptake, the response to the Valsalva maneuver, and spectral analyses of the RR interval and blood pressure in 20 patients with de novo PD without OH. Decreased cardiac MIBG uptake was found even in patients with PD without OH. Hemodynamic studies using the Valsalva maneuver revealed that patients with PD without OH had preserved baroreceptor reflex sensitivity in phase II and phase IV. Blood pressures normally responded in early and late phase II, but not in phase IV. Blood pressure recovery time was slightly reduced in patients with PD without OH when compared with the value in controls. The low frequency component of the RR interval and systolic blood pressure and the ratio of RR-LF to RR-HF in de novo PD without OH were significantly reduced when compared with the control values, whereas the high frequency component of the RR interval did not differ significantly. These results show that latent cardiac and vasomotor sympathetic dysfunction but not parasympathetic dysfunction is already present in early stage de novo PD, even without orthostatic hypotension. © 2010 The Author(s). European Journal of Neurology © 2010 EFNS.

  15. Whole exome sequencing reveals a MLL de novo mutation ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 94; Issue 4. Whole exome sequencing reveals a de novo mutation associated with mild developmental delay ... Keywords. Wiedemann–Steiner syndrome; whole exome sequencing; hairy elbows; hypertrichosis cubiti; gene; KMT2A; developmental delay; children.

  16. Earliest record of the invasive Foraminifera Trochammina hadai in San Francisco Bay, California, USA

    Science.gov (United States)

    McGann, Mary

    2014-01-01

    In 1995, Trochammina hadai, a benthic Foraminifera prevalent in Japanese estuaries, was found in San Francisco Bay, California, USA. Subsequent field investigations determined that the species was also present in nearly all of the major ports and estuaries along the western United States. Because of its widespread colonization, it is of interest to determine when T. hadai first appeared as an invasive in the coastal regions of the North Pacific. In San Francisco Bay, the species was not found in 404 surface samples collected between 1930 and 1981. In 1983, however, a grab sediment sample from one of four sites in the southern portion of the bay contained T. hadai. This site was the most northern of the four and contained 12 specimens of the invasive, comprising 1.5% of the assemblage. This is the earliest appearance on record of T. hadai in San Francisco Bay.

  17. The construction of a revitalization program for the São Francisco River watershed

    OpenAIRE

    Machado, Antonio Thomaz da Mata

    2008-01-01

    A construção de um Programa de Revitalização da bacia do Rio São Francisco está em curso. Um decreto presidencial de 2001 e os Planos de Recursos Hídricos das bacias dos rios São Francisco e Velhas introduziram critérios e conceitos inovadores na definição de propostas para a recuperação hidroambiental de bacias hidrográficas. A polêmica em torno das obras de transposição de águas do Rio São Francisco e da implementação da lei das águas na bacia determina o processo de construção do programa....

  18. Homeless Gay and Transgender Youth of Color in San Francisco: "No One Likes Street Kids"--Even in the Castro

    Science.gov (United States)

    Reck, Jen

    2009-01-01

    This study, focused on five transgender and gay youth of color from San Francisco, explored how family problems, poverty, homophobia, and transphobia propelled them into homelessness and made gay-friendly spaces and resources especially meaningful to them. These young people describe seeking support in San Francisco's well-known gay enclave, the…

  19. 78 FR 13890 - Notice of Intent To Repatriate Cultural Items: San Francisco State University NAGPRA Program, San...

    Science.gov (United States)

    2013-03-01

    ... Intent To Repatriate Cultural Items: San Francisco State University NAGPRA Program, San Francisco, CA... NAGPRA Program, in consultation with the appropriate Indian tribe, has determined that the cultural items... tribe that believes itself to be culturally affiliated with the cultural items may contact the San...

  20. 77 FR 32716 - Price for the 2012 American Eagle San Francisco Two-Coin Silver Proof Set

    Science.gov (United States)

    2012-06-01

    ... DEPARTMENT OF THE TREASURY United States Mint Price for the 2012 American Eagle San Francisco Two...: The United States Mint is announcing the price of the 2012 American Eagle San Francisco Two-Coin Silver Proof Set. The coin set will be offered for sale at a price of $149.95. FOR FURTHER INFORMATION...

  1. Carcinoma de mama: novos conceitos na classificação Breast cancer: new concepts in classification

    Directory of Open Access Journals (Sweden)

    Daniella Serafin Couto Vieira

    2008-01-01

    Full Text Available O carcinoma de mama é a neoplasia maligna mais comum em mulheres. Estudos moleculares do carcinoma de mama, baseados na identificação do perfil de expressão gênica por meio do cDNA microarray, permitiram definir pelo menos cinco sub-grupos distintos: luminal A, luminal B, superexpressão do HER2, basal e normal breast-like. A técnica de tissue microarray (TMA, descrita pela primeira vez em 1998, permitiu estudar, em várias amostras de carcinoma, os perfis de expressão protéica de diferentes neoplasias. No carcinoma de mama, os TMAs têm sido utilizados para validar os achados dos estudos preliminares, identificando, desta forma, os novos subtipos fenotípicos do carcinoma de mama. Dentre os subtipos classicamente descritos, o grupo basal constitui um dos mais intrigantes subtipos tumorais e é freqüentemente associado com pior prognóstico e ausência de alvos terapêuticos definidos. A classificação histopatológica do carcinoma de mama tem pobre valor preditivo. Portanto, a associação entre o diagnóstico histológico com técnicas moleculares nos laboratórios de anatomia patológica, por meio do estudo imunoistoquímico, pode determinar o perfil molecular do carcinoma de mama, buscando melhorar a resposta terapêutica. Este estudo visou resumir os mais recentes conhecimentos em que se baseiam os novos conceitos da classificação do carcinoma de mama.Breast cancer is the principal cause of death from cancer in women. Molecular studies of breast cancer, based in the identification of the molecular profiling techniques through cDNA microarray, had allowed defining at least five distinct sub-group: luminal A, luminal B, HER-2-overexpression, basal and " normal" type breast-like. The technique of tissue microarrays (TMA, described for the first time in 1998, allows to study, in some samples of breast cancer, distinguished by differences in their gene expression patterns, which provide a distinctive molecular portrait for each tumor

  2. Cannabis policies and user practices: market separation, price, potency, and accessibility in Amsterdam and San Francisco.

    Science.gov (United States)

    Reinarman, Craig

    2009-01-01

    This paper explores user perceptions and practices in contrasting legal-policy milieux-Amsterdam (de facto decriminalization) and San Francisco (de jure criminalization) on four policy issues: sources of cannabis and separation of markets for it and other drugs; user perceptions of effects of price on consumption; effects of potency on consumption; and perceived risk of arrest and accessibility of cannabis. Questions on these issues were added to surveys on career use patterns amongst representative samples of experienced cannabis users using comparable methods. Most San Francisco respondents obtained cannabis through friends who knew dealers, whereas most Amsterdam respondents obtained it from regulated shops. Only one in seven Amsterdam respondents but half the San Francisco respondents could obtain other drugs from their cannabis sources. Majorities under both systems had never found cannabis "too expensive." Amsterdam respondents preferred milder cannabis whilst San Francisco respondents preferred stronger; majorities in both cities reported self-titrating with potent cannabis. Risk and fear of arrest were higher in San Francisco, but most in both cities perceived arrest as unlikely. Estimated search times were somewhat longer in San Francisco, but a majority reported being able to access it within half a day. There is substantial separation of markets in the Dutch system. Policies designed to increase cannabis prices appear unlikely to impact consumption. Decriminalization was associated with a preference for milder cannabis, but under both policy regimes most respondents self-titrated when using more potent strains. Criminalization was associated with somewhat higher risk and fear of arrest and somewhat longer search times, but these did not appear to significantly impede access for most respondents.

  3. Genome-wide patterns and properties of de novo mutations in humans

    NARCIS (Netherlands)

    Francioli, Laurent C.; Polak, Paz P.; Koren, Amnon; Menelaou, Androniki; Chun, Sung; Renkens, Ivo; van Duijn, Cornelia M.; Swertz, Morris; Wijmenga, Cisca; van Ommen, Gertjan; Slagboom, P. Eline; Boomsma, Dorret I.; Ye, Kai; Guryev, Victor; Arndt, Peter F.; Kloosterman, Wigard P.; de Bakker, Paul I. W.; Sunyaev, Shamil R.

    Mutations create variation in the population, fuel evolution and cause genetic diseases. Current knowledge about de novo mutations is incomplete and mostly indirect(1-10). Here we analyze 11,020 de novo mutations from the whole genomes of 250 families. We show that de novo mutations in the offspring

  4. Genome-wide patterns and properties of de novo mutations in humans

    NARCIS (Netherlands)

    Francioli, L.C.; Polak, P.P.; Koren, A.; Menelaou, A.; Chun, S.; Renkens, I.; van Duijn, C.M.; Swertz, M.A.; Wijmenga, C.; van Ommen, G.J.; Slagboom, P.E.; Boomsma, D.I.; Ye, K.; Guryev, V.; Arndt, P.F.; Kloosterman, W.P.; Bakker, P.I.W.; Sunyaev, S.R.; Dijk, F.; Neerincx, P.B.T.; Pulit, S.L.; Deelen, P.; Elbers, C.C.; Palamara, P.F.; Pe'er, I.; Abdellaoui, A.; van Oven, M.; Vermaat, M.; Li, M.; Laros, J.F.J.; Stoneking, M.; de Knijff, P.; Kayser, M.; Veldink, J.H.; Van den Berg, L.H.; Byelas, H.; den Dunnen, J.T.; Dijkstra, M.; Amin, N.; van der Velde, K.J.; Hottenga, J.J.; van Setten, J.; van Leeuwen, E.M.; Kanterakis, A.; Kattenberg, V.M.; Karssen, L.C.; van Schaik, B.D.C.; Bot, J.; Nijman, I.J.; van Enckevort, D.; Mei, H.; Koval, V.; Estrada, K.; Medina-Gomez, C.; Lameijer, E.W.; Moed, M.H.; Hehir-Kwa, J.Y.; Handsaker, R.E.; McCarroll, S.A.; Vuzman, D.; Sohail, M.; Hormozdiari, F.; Marschall, T.; Schönhuth, A.; Beekman, M.; de Craen, A.J.; Suchiman, H.E.D.; Hofman, A.; Oostra, B.; Isaacs, A.; Rivadeneira, F.; Uitterlinden, A.G.; Willemsen, G.; Platteel, M.; Pitts, S.J.; Potluri, S.; Sundar, P.; Cox, D.R.; Li, Q.; Li, Y.; Du, Y.; Chen, R.; Cao, H.; Li, N.; Cao, S.; Wang, J.; Bovenberg, J.A.; Brandsma, M.

    2015-01-01

    Mutations create variation in the population, fuel evolution and cause genetic diseases. Current knowledge about de novo mutations is incomplete and mostly indirect. Here we analyze 11,020 de novo mutations from the whole genomes of 250 families. We show that de novo mutations in the offspring of

  5. A economia política brasileira na obra de Francisco de Oliveira

    OpenAIRE

    Moret, Alex Hotz

    2011-01-01

    Este trabalho busca relatar as principais contribuições de Francisco de Oliveira para o entendimento da economia política brasileira. Para isso, dividiu-se a produção teórica do autor em três fases, desde a publicação do artigo Critica à razão dualista até o seu mais recente trabalho, intitulado O ornitorrinco. O objetivo da análise é apresentar, em cada fase da obra do autor, as contribuições inseridas por Francisco de Oliveira no debate teórico nacional. Inicialmente será ...

  6. Magma mixing in the San Francisco Volcanic Field, AZ

    Science.gov (United States)

    Bloomfield, Anne L.; Arculus, Richard J.

    1989-08-01

    A wide variety of rock types are present in the O'Leary Peak and Strawberry Crater volcanics of the Pliocene to Recent San Francisco Volcanic Field (SFVF), AZ. The O'Leary Peak flows range from andesite to rhyolite (56 72 wt % SiO2) and the Strawberry Crater flows range from basalt to dacite (49 64 wt % SiO2). Our interpretation of the chemical data is that both magma mixing and crustal melting are important in the genesis of the intermediate composition lavas of both suites. Observed chemical variations in major and trace elements can be modeled as binary mixtures between a crustal melt similar to the O'Leary dome rhyolite and two different mafic end-members. The mafic end-member of the Strawberry suite may be a primary mantle-derived melt. Similar basalts have also been erupted from many other vents in the SFVF. In the O'Leary Peak suite, the mafic end-member is an evolved (low Mg/(Mg+ Fe)) basalt that is chemically distinct from the Strawberry Crater and other vent basalts as it is richer in total Fe, TiO2, Al2O3, MnO, Na2O, K2O, and Zr and poorer in MgO, CaO, P2O5, Ni, Sc, Cr, and V. The derivative basalt probably results from fractional crystallization of the more primitive, vent basalt type of magma. This evolved basalt occurs as xenolithic (but originally magmatic) inclusions in the O'Leary domes and andesite porphyry flow. The most mafic xenolith may represent melt that mixed with the O'Leary dome rhyolite resulting in andesite preserved as other xenoliths, a pyroclastic unit (Qoap), porphyry flow (Qoaf) and dacite (Darton Dome) magmas. Thermal constraints on the capacity of a melt to assimilate (and melt) a volume of solid material require that melt mixing and not assimilation has produced the observed intermediate lavas at both Strawberry Crater and O'Leary Peak. Textures, petrography, and mineral chemistry support the magma mixing model. Some of the inclusions have quenched rims where in contact with the host. The intermediate rocks, including the

  7. Novo desenvolvimentismo e liberalismo enraizado New developmentalism and embedded liberalism

    Directory of Open Access Journals (Sweden)

    Reinaldo Gonçalves

    2012-12-01

    Full Text Available O objetivo geral deste artigo é discutir a evolução da formulação político‑ideológica de desenvolvimento econômico conhecida como novo desenvolvimentismo. O objetivo específico é demonstrar a hipótese de que o novo desenvolvimentismo é mais uma versão do liberalismo enraizado, que exprime o compromisso entre as diretrizes estratégicas do liberalismo e a intervenção estatal orientada para a estabilização macroeconômica.The general objective of this article is to discuss the evolution of the political and ideological formulation of the economic development known as new developmentalism. The specific objective is to demonstrate the hypothesis that the new developmentalism is a version of the embedded liberalism, that expresses the compromise between the strategic guidelines of the liberalism and the state interventionism focused on macroeconomic stabilization.

  8. Kokes Awards for the 21st NAM Meeting (San Francisco, CA, 2009)

    Energy Technology Data Exchange (ETDEWEB)

    Katz, Alex [Univ. of California, Berkeley, CA (United States)

    2009-08-31

    The PI in this project Alexander Katz, UC Berkeley (askatz@berkeley.edu), in conjunction with the Kokes Awards subcommittee and conference organizing committee, used DOE grant DE-FG-02-08ER15993 to partially offset costs of attending the 21st North American Catalysis Society in San Francisco, California, for 30 graduate students from the United States.

  9. Communications and Collaboration Keep San Francisco VA Medical Center Project on Track

    International Nuclear Information System (INIS)

    Federal Energy Management Program

    2001-01-01

    This case study about energy saving performance contacts (ESPCs) presents an overview of how the Veterans Affairs Medical Center in San Francisco established an ESPC contract and the benefits derived from it. The Federal Energy Management Program instituted these special contracts to help federal agencies finance energy-saving projects at their facilities

  10. CAREER TRAINING IN HOTEL AND RESTAURANT OPERATION...AT CITY COLLEGE OF SAN FRANCISCO.

    Science.gov (United States)

    BATMALE, LOUIS F.; MULLANY, GEORGE G.

    THE HOTEL AND RESTAURANT PROGRAM, ONE OF 35 SEMIPROFESSIONAL TRAINING PROGRAMS AT CITY COLLEGE OF SAN FRANCISCO, COMBINES GENERAL EDUCATION, RELATED BUSINESS INSTRUCTION, HOTEL AND RESTAURANT CLASSES, FOOD PREPARATION AND SERVICE TRAINING, AND WORK EXPERIENCE. THIS DESCRIPTION OF THE PROGRAM INCLUDES (1) PURPOSES AND OBJECTIVES, (2) CURRICULUM,…

  11. Viewing the Afro-Mexican Female Revolutionary: Francisco Rojas Gonzalez's "La negra Angustias"

    Science.gov (United States)

    Kanost, Laura

    2010-01-01

    Francisco Rojas Gonzalez's 1944 novel "La negra Angustias" is recognized as the only novel of the Mexican Revolution that features a black woman military officer. Critics have observed that, although this semi-biographical novel portrays Angustias as a gender nonconformist who seeks justice for women and the poor, the conclusion ushers…

  12. City College of San Francisco 1997 Sexual Harassment Student Opinion Survey.

    Science.gov (United States)

    City Coll. of San Francisco, CA. Office of Institutional Research, Planning and Grants.

    This document describes the findings of a 1997 sexual harassment student opinion survey conducted at City College of San Francisco. Survey questions were jointly developed by the Sexual Harassment Prevention Sub-Committee of the Diversity Advisory Committee and the Office of Research and Planning, approved by the College Advisory Council, and…

  13. Humberto R. Maturana and Francisco J. Varela on Science and the Humanities: The Poerksen Interviews

    Science.gov (United States)

    Journal of Aesthetic Education, 2006

    2006-01-01

    This article deals with Bernhard Poerksen's interviews with Humberto R. Maturana and Francisco J. Varela on science and the humanities. In Poerksen's conversation with Maturana, they talk about the: (1) responsibility of the teacher; (2) listening to the listening; (3) perception and illusion; and (4) all human beings are equally intelligent. In…

  14. Dogs Are Talking: San Francisco's social marketing campaign to increase syphilis screening.

    Science.gov (United States)

    Stephens, Sally C; Bernstein, Kyle T; McCright, Jacqueline E; Klausner, Jeffrey D

    2010-03-01

    To promote regular syphilis testing among men who have sex with men in San Francisco, a social marketing campaign, Dogs Are Talking, was created. An evaluation of the campaign found no difference in syphilis testing among men who recalled the campaign and those that did not. A significant difference was seen among HIV-infected men.

  15. Travel and Tourism Industry: Program Options for City College of San Francisco.

    Science.gov (United States)

    City Coll. of San Francisco, CA.

    In an effort to determine the current occupational outlook and resulting implications for education and training, the City College of San Francisco (CCSF), in California, undertook a study of current trends in the travel and tourism industry. This report provides findings from the project, which involved consultation with local and national…

  16. 33 CFR 165.1192 - Security Zones; Waters surrounding San Francisco International Airport and Oakland International...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zones; Waters..., California. 165.1192 Section 165.1192 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Security Zones; Waters surrounding San Francisco International Airport and Oakland International Airport...

  17. The Quality Teacher and Education Act in San Francisco: Lessons Learned. Policy Brief 09-2

    Science.gov (United States)

    Hough, Heather J.

    2009-01-01

    This policy brief reviews the recent experience of the San Francisco Unified School District (SFUSD) with the development and approval of Proposition A. Proposition A (also known as the Quality Teacher and Education Act, or QTEA) included a parcel tax mainly dedicated to increasing teachers' salaries, along with a variety of measures introducing…

  18. Em nome do Pai: o Francisco de Assis de Leonardo Boff

    Directory of Open Access Journals (Sweden)

    Marcelo Timotheo da Costa

    Full Text Available RESUMO O presente texto analisa a imagem de Francisco de Assis construída por Leonardo Boff. Discute-se aqui como o ainda frade franciscano Boff respondeu às sanções disciplinares a ele impostas pela Santa Sé, reação expressa no livro Francisco de Assis: a saudade do Paraíso (1985. Nessa obra, um exercício memorial inspirado em fontes franciscanas primitivas, Boff vai além da mera celebração da legenda de Francisco de Assis, apresentando o santo medieval como ícone da Teologia da Libertação, crente paradigmático para nosso tempo e patrono das causas populares. Assim, interpretando Francisco de Assis por intermédio dos ideais cristãos liberacionistas, Boff contestou seus adversários, ratificando sua teologia militante. Por fim, ele proclamou projeto político de oposição à ordem estabelecida no Brasil e na Igreja Católica.

  19. 77 FR 4501 - Special Local Regulation and Safety Zone; America's Cup Sailing Events, San Francisco, CA

    Science.gov (United States)

    2012-01-30

    ... body of your document so that we can contact you if we have questions regarding your submission. To... media. In San Francisco, they propose to take advantage of the natural amphitheater that the Central Bay... exceptional circumstances subject to COTP determination. Images of the primary and contingent regulated areas...

  20. Realizing a Progressive Pedagogy: A Comparative Case Study of Two Reggio Emilia Preschools in San Francisco

    Science.gov (United States)

    Abdelfattah, Marwa

    2015-01-01

    This study aims to uncover how a particular imported philosophy of early childhood education, Reggio Emilia, is implemented in the context of one public and one private preschool in San Francisco. The philosophy of Reggio Emilia is believed to be progressive and to be developmentally appropriate for children in early childhood. The study involved…

  1. Indigenous Peoples and the Struggle in Defense of the São Francisco River

    Directory of Open Access Journals (Sweden)

    Rinaldo Sérgio Vieira Arruda

    2013-12-01

    Full Text Available The objective of this article is to reflect about the indigenous people who live in the São Francisco river area and how they act in defense of its preservation. In a time that agribusiness is becoming stronger and dams and the canal to divert that river are in construction, many social and environmental conflicts have arisen in that region. The Environment Impact Studies do not take in account the dynamic of those indigenous peoples with their land and how they relate to the São Francisco river. Based on bibliographical research about the conflicts that come with those projects, we conclude that those projects repeat the mistakes from the past in its relation with those indigenous people. The objective of this article is to reflect about the indigenous people who live in the São Francisco river area and how they act in defense of its preservation. In a time that agribusiness is becoming stronger and dams and the canal to divert that river are in construction, many social and environmental conflicts have arisen in that region. The Environment Impact Studies do not take in account the dynamic of those indigenous peoples with their land and how they relate to the São Francisco river. Based on bibliographical research about the conflicts that come with those projects, we conclude that those projects repeat the mistakes from the past in its relation with those indigenous people.

  2. 78 FR 75249 - Safety Zone: Google's Night at Sea Fireworks Display, San Francisco Bay, Alameda, CA

    Science.gov (United States)

    2013-12-11

    ...-AA00 Safety Zone: Google's Night at Sea Fireworks Display, San Francisco Bay, Alameda, CA AGENCY: Coast... Google's Night at Sea Fireworks Displays on December 7, 2013 and December 14, 2013. These safety zones... Coast Guard to establish safety zones. Google will sponsor the Google's Night at Sea Fireworks Displays...

  3. The San Francisco Peace Treaty: The Cold War and the Peace Process.

    Science.gov (United States)

    Brunette, Rachel

    International treaties have played a central role in diplomatic history since the rise of the modern nation state. Since the end of World War II, more treaties have been formed than in the preceding four centuries. The year 2001 marks the 50th anniversary of the San Francisco Peace Treaty. This unit provides students with historical knowledge of…

  4. Melhoramento do cafeeiro: IV - Café Mundo Novo

    Directory of Open Access Journals (Sweden)

    A. Carvalho

    1952-06-01

    Full Text Available Em um conjunto de cafeeiros existentes em Mundo Novo, hoje Urupês, na região Araraquarense do Estado de São Paulo, foram feitas seleções de vários cafeeiros baseando-se no seu aspecto vegetativo, na produção existente na época da seleção e na provável produção do ano seguinte. Estudou-se a origem da plantação inicial desse café, tanto em Urupês como em Jaú, chegando-se à conclusão de que é provavelmente originário desta última localidade. Progênies do café "Mundo Novo", anteriormente conhecido por "Sumatra" e derivado de plantas selecionadas em Urupês e Jaú, acham-se em estudo em seis localidades do Estado : Campinas, Ribeirão Prêto, Pindorama, Mococa, Jaú e Monte Alegre do Sul. No presente trabalho são apenas aproveitados dados referentes à variabilidade morfológica e característicos da produção das progênies dos primeiros cafeeiros selecionados em Urupês e estudados em Campinas, Jaú, Pindorama e Mococa. Em tôdas as localidades, observou-se variação nos caracteres morfológicos das progênies, verificando-se a ocorrência de plantas quase improdutivas. A maioria das progênies, no entanto, se caracteriza por acentuado vigor vegetativo. Foram estudadas as produções totais das progénies e das plantas, no período 1946-1951, notando-se que algumas progénies se salientaram pela elevada produção em tôdas as localidades. Os tipos de sementes "moca", "concha" e "chato" foram determinados em amostras de tôdas as plantas, por um período de três anos, notando-se que a variação ocorrida é da mesma ordem que a encontrada em outros cafeeiros em seleção. Procurou-se eliminar, pela seleção, cafeeiros com elevada produção de frutos sem sementes em uma ou duas lojas, característico êsse que parece ser hereditário. Os resultados obtidos de cruzamento entre os melhores cafeeiros "Mundo Novo" de Campinas e plantas da variedade murta, indicaram que esses cafeeiros são do tipo bourbon. Provavelmente

  5. Infant Mortality in Novo Hamburgo: Associated Factors and Cardiovascular Causes

    Energy Technology Data Exchange (ETDEWEB)

    Brum, Camila de Andrade [Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, RS (Brazil); Stein, Airton Tetelbom [Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS (Brazil); Grupo Hospitalar Conceição (GHC), Porto Alegre, RS (Brazil); Universidade Luterana do Brasil (ULBRA), Porto Alegre, RS (Brazil); Pellanda, Lucia Campos, E-mail: luciapell.pesquisa@cardiologia.org.br [Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, RS (Brazil); Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS (Brazil)

    2015-04-15

    Infant mortality has decreased in Brazil, but remains high as compared to that of other developing countries. In 2010, the Rio Grande do Sul state had the lowest infant mortality rate in Brazil. However, the municipality of Novo Hamburgo had the highest infant mortality rate in the Porto Alegre metropolitan region. To describe the causes of infant mortality in the municipality of Novo Hamburgo from 2007 to 2010, identifying which causes were related to heart diseases and if they were diagnosed in the prenatal period, and to assess the access to healthcare services. This study assessed infants of the municipality of Novo Hamburgo, who died, and whose data were collected from the infant death investigation records. Of the 157 deaths in that period, 35.3% were reducible through diagnosis and early treatment, 25% were reducible through partnership with other sectors, 19.2% were non-preventable, 11.5% were reducible by means of appropriate pregnancy monitoring, 5.1% were reducible through appropriate delivery care, and 3.8% were ill defined. The major cause of death related to heart disease (13.4%), which was significantly associated with the variables ‘age at death’, ‘gestational age’ and ‘birth weight’. Regarding access to healthcare services, 60.9% of the pregnant women had a maximum of six prenatal visits. It is mandatory to enhance prenatal care and newborn care at hospitals and basic healthcare units to prevent infant mortality.

  6. Infant Mortality in Novo Hamburgo: Associated Factors and Cardiovascular Causes

    Directory of Open Access Journals (Sweden)

    Camila de Andrade Brum

    2015-04-01

    Full Text Available Background: Infant mortality has decreased in Brazil, but remains high as compared to that of other developing countries. In 2010, the Rio Grande do Sul state had the lowest infant mortality rate in Brazil. However, the municipality of Novo Hamburgo had the highest infant mortality rate in the Porto Alegre metropolitan region. Objective: To describe the causes of infant mortality in the municipality of Novo Hamburgo from 2007 to 2010, identifying which causes were related to heart diseases and if they were diagnosed in the prenatal period, and to assess the access to healthcare services. Methods: This study assessed infants of the municipality of Novo Hamburgo, who died, and whose data were collected from the infant death investigation records. Results: Of the 157 deaths in that period, 35.3% were reducible through diagnosis and early treatment, 25% were reducible through partnership with other sectors, 19.2% were non-preventable, 11.5% were reducible by means of appropriate pregnancy monitoring, 5.1% were reducible through appropriate delivery care, and 3.8% were ill defined. The major cause of death related to heart disease (13.4%, which was significantly associated with the variables ‘age at death’, ‘gestational age’ and ‘birth weight’. Regarding access to healthcare services, 60.9% of the pregnant women had a maximum of six prenatal visits. Conclusion: It is mandatory to enhance prenatal care and newborn care at hospitals and basic healthcare units to prevent infant mortality.

  7. O paradigma do desenvolvimento: do mito fundador ao novo desenvolvimento

    Directory of Open Access Journals (Sweden)

    Anete B.L. Ivo

    Full Text Available Este artigo busca historicizar contextos que reorientaram a noção de desenvolvimento, no Brasil, desde os anos 30-80, passando pelo ajuste neoliberal dos anos 90, até inflexões atuais que indagam se o novo intervencionismo massivo e estratégico do Estado em políticas sociais para os mais pobres aponta para um novo modelo de desenvolvimento. A análise apresenta inflexões do modelo cepalino de 50-60 e tenta priorizar dimensões sociais na mediação das contradições entre a economia, a política e o institucional. O fio condutor toma dois vetores analíticos: o tema do conflito (redistributivo e o da integração. O primeiro é assentado nas coalizões das classes e confronto entre atores nacionais e agências multilaterais; e o da integração, na contraface do conflito, considera a abertura das políticas públicas e, também, a inovação de atores sociais e políticos em novos arranjos voltados para os objetivos do bem-estar social e da cidadania, de uma perspectiva mais sustentada.

  8. Tinindo Trincando: Contracultura e rock no samba dos Novos Baianos

    Directory of Open Access Journals (Sweden)

    VARGAS, Herom

    2011-12-01

    Full Text Available The aim of this article is to discuss aspects linked to counterculture and rock in musical production of the Brazilian band Novos Baianos in the 70’s. Having the context of Brazilian popular music from that decade as a background, two points will be discussed: 1 the particular understanding of counterculture made by the band, and 2 the experimental mix between rock and Brazilian popular musical genres. The counterculture aspects – according to Roszak (1972, Muggiatti (1981, Goffman e Joy (2007, Risério (2005, Dunn (2001; 2002 – will be observed from memories of one of the band’s leaders, the lyricist Luiz Galvão, in his book Anos 70: novos e baianos (1997, and from the scenes of the movie Novos Baianos F.C., directed by Solano Ribeiro (1973. On musical experimentation, some of their songs recorded in the 70’s point the ways of use of rock’s aesthetic elements, especially in guitar arrangements of the musician Pepeu Gomes

  9. Infant Mortality in Novo Hamburgo: Associated Factors and Cardiovascular Causes

    International Nuclear Information System (INIS)

    Brum, Camila de Andrade; Stein, Airton Tetelbom; Pellanda, Lucia Campos

    2015-01-01

    Infant mortality has decreased in Brazil, but remains high as compared to that of other developing countries. In 2010, the Rio Grande do Sul state had the lowest infant mortality rate in Brazil. However, the municipality of Novo Hamburgo had the highest infant mortality rate in the Porto Alegre metropolitan region. To describe the causes of infant mortality in the municipality of Novo Hamburgo from 2007 to 2010, identifying which causes were related to heart diseases and if they were diagnosed in the prenatal period, and to assess the access to healthcare services. This study assessed infants of the municipality of Novo Hamburgo, who died, and whose data were collected from the infant death investigation records. Of the 157 deaths in that period, 35.3% were reducible through diagnosis and early treatment, 25% were reducible through partnership with other sectors, 19.2% were non-preventable, 11.5% were reducible by means of appropriate pregnancy monitoring, 5.1% were reducible through appropriate delivery care, and 3.8% were ill defined. The major cause of death related to heart disease (13.4%), which was significantly associated with the variables ‘age at death’, ‘gestational age’ and ‘birth weight’. Regarding access to healthcare services, 60.9% of the pregnant women had a maximum of six prenatal visits. It is mandatory to enhance prenatal care and newborn care at hospitals and basic healthcare units to prevent infant mortality

  10. Generative Recurrent Networks for De Novo Drug Design.

    Science.gov (United States)

    Gupta, Anvita; Müller, Alex T; Huisman, Berend J H; Fuchs, Jens A; Schneider, Petra; Schneider, Gisbert

    2018-01-01

    Generative artificial intelligence models present a fresh approach to chemogenomics and de novo drug design, as they provide researchers with the ability to narrow down their search of the chemical space and focus on regions of interest. We present a method for molecular de novo design that utilizes generative recurrent neural networks (RNN) containing long short-term memory (LSTM) cells. This computational model captured the syntax of molecular representation in terms of SMILES strings with close to perfect accuracy. The learned pattern probabilities can be used for de novo SMILES generation. This molecular design concept eliminates the need for virtual compound library enumeration. By employing transfer learning, we fine-tuned the RNN's predictions for specific molecular targets. This approach enables virtual compound design without requiring secondary or external activity prediction, which could introduce error or unwanted bias. The results obtained advocate this generative RNN-LSTM system for high-impact use cases, such as low-data drug discovery, fragment based molecular design, and hit-to-lead optimization for diverse drug targets. © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  11. San Francisco Syncope Rule to predict short-term serious outcomes: a systematic review

    Science.gov (United States)

    Saccilotto, Ramon T.; Nickel, Christian H.; Bucher, Heiner C.; Steyerberg, Ewout W.; Bingisser, Roland; Koller, Michael T.

    2011-01-01

    Background: The San Francisco Syncope Rule has been proposed as a clinical decision rule for risk stratification of patients presenting to the emergency department with syncope. It has been validated across various populations and settings. We undertook a systematic review of its accuracy in predicting short-term serious outcomes. Methods: We identified studies by means of systematic searches in seven electronic databases from inception to January 2011. We extracted study data in duplicate and used a bivariate random-effects model to assess the predictive accuracy and test characteristics. Results: We included 12 studies with a total of 5316 patients, of whom 596 (11%) experienced a serious outcome. The prevalence of serious outcomes across the studies varied between 5% and 26%. The pooled estimate of sensitivity of the San Francisco Syncope Rule was 0.87 (95% confidence interval [CI] 0.79–0.93), and the pooled estimate of specificity was 0.52 (95% CI 0.43–0.62). There was substantial between-study heterogeneity (resulting in a 95% prediction interval for sensitivity of 0.55–0.98). The probability of a serious outcome given a negative score with the San Francisco Syncope Rule was 5% or lower, and the probability was 2% or lower when the rule was applied only to patients for whom no cause of syncope was identified after initial evaluation in the emergency department. The most common cause of false-negative classification for a serious outcome was cardiac arrhythmia. Interpretation: The San Francisco Syncope Rule should be applied only for patients in whom no cause of syncope is evident after initial evaluation in the emergency department. Consideration of all available electrocardiograms, as well as arrhythmia monitoring, should be included in application of the San Francisco Syncope Rule. Between-study heterogeneity was likely due to inconsistent classification of arrhythmia. PMID:21948723

  12. De novo copy number variations in cloned dogs from the same nuclear donor.

    Science.gov (United States)

    Jung, Seung-Hyun; Yim, Seon-Hee; Oh, Hyun Ju; Park, Jung Eun; Kim, Min Jung; Kim, Geon A; Kim, Tae-Min; Kim, Jin-Soo; Lee, Byeong Chun; Chung, Yeun-Jun

    2013-12-09

    Somatic mosaicism of copy number variants (CNVs) in human body organs and de novo CNV event in monozygotic twins suggest that de novo CNVs can occur during mitotic recombination. These de novo CNV events are important for understanding genetic background of evolution and diverse phenotypes. In this study, we explored de novo CNV event in cloned dogs with identical genetic background. We analyzed CNVs in seven cloned dogs using the nuclear donor genome as reference by array-CGH, and identified five de novo CNVs in two of the seven clones. Genomic qPCR, dye-swap array-CGH analysis and B-allele profile analysis were used for their validation. Two larger de novo CNVs (5.2 Mb and 338 Kb) on chromosomes X and 19 in clone-3 were consistently validated by all three experiments. The other three smaller CNVs (sized from 36.1 to 76.4 Kb) on chromosomes 2, 15 and 32 in clone-3 and clone-6 were verified by at least one of the three validations. In addition to the de novo CNVs, we identified a 37 Mb-sized copy neutral de novo loss of heterozygosity event on chromosome 2 in clone-6. To our knowledge, this is the first report of de novo CNVs in the cloned dogs which were generated by somatic cell nuclear transfer technology. To study de novo genetic events in cloned animals can help understand formation mechanisms of genetic variants and their biological implications.

  13. Sediment Deposition, Erosion, and Bathymetric Change in Central San Francisco Bay: 1855-1979

    Science.gov (United States)

    Fregoso, Theresa A.; Foxgrover, Amy C.; Jaffe, Bruce E.

    2008-01-01

    Central San Francisco Bay is the hub of a dynamic estuarine system connecting the San Joaquin and Sacramento River Deltas, Suisun Bay, and San Pablo Bay to the Pacific Ocean and South San Francisco Bay. To understand the role that Central San Francisco Bay plays in sediment transport throughout the system, it is necessary to first determine historical changes in patterns of sediment deposition and erosion from both natural and anthropogenic forces. The first extensive hydrographic survey of Central San Francisco Bay was conducted in 1853 by the National Ocean Service (NOS) (formerly the United States Coast and Geodetic Survey (USCGS)). From 1894 to 1979, four additional surveys, composed of a total of approximately 700,000 bathymetric soundings, were collected within Central San Francisco Bay. Converting these soundings into accurate bathymetric models involved many steps. The soundings were either hand digitized directly from the original USCGS and NOS hydrographic sheets (H-sheets) or obtained digitally from the National Geophysical Data Center's (NGDC) Geophysical Data System (GEODAS) (National Geophysical Data Center, 1996). Soundings were supplemented with contours that were either taken directly from the H-sheets or added in by hand. Shorelines and marsh areas were obtained from topographic sheets. The digitized soundings, depth contours, shorelines, and marsh areas were entered into a geographic information system (GIS) and georeferenced to a common horizontal datum. Using surface modeling software, bathymetric grids with a horizontal resolution of 25 m were developed for each of the five hydrographic surveys. Before analyses of sediment deposition and erosion were conducted, interpolation bias was removed and all of the grids were converted to a common vertical datum. These bathymetric grids were then used to develop bathymetric change maps for subsequent survey periods and to determine long-term changes in deposition and erosion by calculating volumes and

  14. Web Access to Digitised Content of the Exhibition Novo Mesto 1848-1918 at the Dolenjska Museum, Novo Mesto

    Directory of Open Access Journals (Sweden)

    Majda Pungerčar

    2013-09-01

    Full Text Available EXTENDED ABSTRACTFor the first time, the Dolenjska museum Novo mesto provided access to digitised museum resources when they took the decision to enrich the exhibition Novo mesto 1848-1918 by adding digital content. The following goals were identified: the digital content was created at the time of exhibition planning and design, it met the needs of different age groups of visitors, and during the exhibition the content was accessible via touch screen. As such, it also served for educational purposes (content-oriented lectures or problem solving team work. In the course of exhibition digital content was accessible on the museum website http://www.novomesto1848-1918.si. The digital content was divided into the following sections: the web photo gallery, the quiz and the game. The photo gallery was designed in the same way as the exhibition and the print catalogue and extended by the photos of contemporary Novo mesto and accompanied by the music from the orchestron machine. The following themes were outlined: the Austrian Empire, the Krka and Novo mesto, the town and its symbols, images of the town and people, administration and economy, social life and Novo mesto today followed by digitised archive materials and sources from that period such as the Commemorative book of the Uniformed Town Guard, the National Reading Room Guest Book, the Kazina guest book, the album of postcards and the Diploma of Honoured Citizen Josip Gerdešič. The Web application was also a tool for a simple and on line selection of digitised material and the creation of new digital content which proved to be much more convenient for lecturing than Power Point presentations. The quiz consisted of 40 questions relating to the exhibition theme and the catalogue. Each question offered a set of three answers only one of them being correct and illustrated by photography. The application auto selected ten questions and valued the answers immediately. The quiz could be accessed

  15. Water quality variability in San Francisco Bay, Some gGeneral lessons from 1996 sampling: 1996 annual report, San Francisco estuary regional monitoring program for trace substances

    Science.gov (United States)

    Cloern, J.E.; Cole, B.E.; Edmunds, J.L.; Baylosis, J.I.

    1997-01-01

    This report describes the results from the 1996 Regional Monitoring Program for Trace Substances (RMP). It is the fourth Annual Report from the RMP which began in 1993 and attempts to synthesize the most obvious data patterns from the last four years. This report includes data from Base Program monitoring activities, as well as results of Pilot and Special Studies conducted or completed in 1996. Additionally, several articles contributed by RMP investigators and others, are included. These articles provide perspective and insight on important contaminant issues identified by the RMP. This summary addresses which kinds of pollutants measured by the RMP appear to be at levels that warrant concern, what kinds of trends may be discerned, and which stations have consistently shown elevated contaminant levels. The goals or general objectives of the RMP are: 1. To obtain high quality baseline data describing the concentrations of toxic and potentially toxic trace elements and organic contaminants in the water and sediment of the San Francisco Estuary. 2. To determine seasonal and annual trends in chemical and biological water quality in the San Francisco Estuary. 3. To continue to develop a data set that can be used to determine long-term trends in the concentrations of toxic and potentially toxic trace elements and organic contaminants in the water and sediments of the San Francisco Estuary. 4. To determine whether water quality and sediment quality in the Estuary at large are in compliance with objectives established by the Basin Plan (the regulatory planning document used by the Regional Water Quality Control Board). 5. To provide a database on water and sediment quality in the Estuary which is compatible with data being developed in other ongoing studies, including wasteload allocation studies and model development, sediment quality objectives development, in-bay studies of dredged material disposal, Interagency Ecological Program (IEP) water quality studies, primary

  16. Metropolitan Transportation Commission, San Francisco Bay area : developing regional objectives and performance measures to improve system operations

    Science.gov (United States)

    2009-04-01

    The Metropolitan Transportation Commission (MTC) uses an objectives-driven, performance-based approach in its transportation planning for the San Francisco Bay Area. This approach focuses attention on transportation investments of highest priority. T...

  17. 77 FR 43161 - Special Local Regulation; San Francisco Bay Navy Fleetweek Parade of Ships and Blue Angels...

    Science.gov (United States)

    2012-07-24

    .... 3. Privacy Act Anyone can search the electronic form of comments received into any of our dockets by... tactical coxswains from Sector San Francisco's boat stations, has led the Coast Guard to determine that a...

  18. Environmental Sensitivity Index (ESI) Atlas: San Francisco Bay - 1998, maps and geographic information systems data (NODC Accession 0036884)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) maps for the shoreline of San Francisco Bay. ESI data characterize estuarine environments and...

  19. DISTRIBUTION AND COMPOSITION OF DISSOLVED AND PARTICULATE ORGANIC CARBON IN NORTHERN SAN FRANCISCO BAY DURING LOW FRESHWATER FLOW CONDITIONS

    Science.gov (United States)

    The distribution of organic matter was studied in northern San Francisco Bay monthly through spring and summer 1996 along the salinity gradient from the Sacramento River to Central Bay. Dissolved constituents included monosaccharides (MONO), total carbohydrates (TCHO), dissolved ...

  20. Uudised : Neeme Järvi San Franciscos. Tõnis Mägi Moskvas. TMKK Norras ja Ungaris / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2000-01-01

    N. Järvi juhatab San Francisco Ooperis Rimski-Korsakovi ooperit "Tsaari mõrsja", esietendus 11. sept. T. Mägi esines 1. sept. Eesti Suursaatkonnas Moskvas. TMKK Kammerkoori kontsertreisidest Norrasse ja Ungarisse

  1. Environmental Sensitivity Index (ESI) Atlas: San Francisco Bay, California maps and geographic information systems data (NODC Accession 0013224)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) maps for the shoreline of San Francisco Bay. ESI data characterize estuarine environments and...

  2. The quest for novel chemical matter and the contribution of computer-aided de novo design.

    Science.gov (United States)

    Pirard, Bernard

    2011-03-01

    Identifying novel chemical matter is the focus of many drug discovery efforts. Through these efforts, computer-based de novo design of drug-like molecules, which aim to build an entire molecule 'from scratch', has emerged as a valuable approach to identify novel chemical matter. In this paper, the author discusses the recent research efforts that aim to build, in silico, more chemically accessible molecules, sample more efficiently the chemical space and rank the proposed molecules. The author reviews de novo design algorithms developed between 2008 and 2010 and the issue of validation, and highlights some recent successful applications of de novo design to drug discovery projects. Although research has addressed the lack of synthetic accessibility of the molecules proposed by the first generation of de novo design tools, the lack of accurate scoring function remains a major limitation of structure-based de novo design. However, de novo design is a valuable approach to generate either chemical starting points or ideas.

  3. De novo assembly of highly diverse viral populations

    Directory of Open Access Journals (Sweden)

    Yang Xiao

    2012-09-01

    Full Text Available Abstract Background Extensive genetic diversity in viral populations within infected hosts and the divergence of variants from existing reference genomes impede the analysis of deep viral sequencing data. A de novo population consensus assembly is valuable both as a single linear representation of the population and as a backbone on which intra-host variants can be accurately mapped. The availability of consensus assemblies and robustly mapped variants are crucial to the genetic study of viral disease progression, transmission dynamics, and viral evolution. Existing de novo assembly techniques fail to robustly assemble ultra-deep sequence data from genetically heterogeneous populations such as viruses into full-length genomes due to the presence of extensive genetic variability, contaminants, and variable sequence coverage. Results We present VICUNA, a de novo assembly algorithm suitable for generating consensus assemblies from genetically heterogeneous populations. We demonstrate its effectiveness on Dengue, Human Immunodeficiency and West Nile viral populations, representing a range of intra-host diversity. Compared to state-of-the-art assemblers designed for haploid or diploid systems, VICUNA recovers full-length consensus and captures insertion/deletion polymorphisms in diverse samples. Final assemblies maintain a high base calling accuracy. VICUNA program is publicly available at: http://www.broadinstitute.org/scientific-community/science/projects/viral-genomics/ viral-genomics-analysis-software. Conclusions We developed VICUNA, a publicly available software tool, that enables consensus assembly of ultra-deep sequence derived from diverse viral populations. While VICUNA was developed for the analysis of viral populations, its application to other heterogeneous sequence data sets such as metagenomic or tumor cell population samples may prove beneficial in these fields of research.

  4. Modeling Magnetic Fields from a DC Power Cable Buried Beneath San Francisco Bay Based on Empirical Measurements

    OpenAIRE

    Kavet, Robert; Wyman, Megan T.; Klimley, A. Peter

    2016-01-01

    The Trans Bay Cable (TBC) is a ±200-kilovolt (kV), 400 MW 85-km long High Voltage Direct Current (DC) buried transmission line linking Pittsburg, CA with San Francisco, CA (SF) beneath the San Francisco Estuary. The TBC runs parallel to the migratory route of various marine species, including green sturgeon, Chinook salmon, and steelhead trout. In July and August 2014, an extensive series of magnetic field measurements were taken using a pair of submerged Geometrics magnetometers towed behind...

  5. Iron, Oil, and Emeryville: Resource Industrialization and Metropolitan Expansion in the San Francisco Bay Area, 1850-1900

    OpenAIRE

    Lunine, Seth

    2013-01-01

    Scholars have largely overlooked the formative role of industry in both California's economic development and the San Francisco Bay Area's metropolitan expansion during the late nineteenth century. Beginning in the early 1880s, leading firms in San Francisco's specialized industries, such as the iron and chemicals sectors, dispersed to the metropolitan periphery. This process of industrial suburbanization created an integrative metropolitan economy, as well as individual suburbs. In this di...

  6. Non-indigenous hydromedusae in California's upper San Francisco Esturary: life cycles, distribution, and potential environmental impacts

    OpenAIRE

    John T. Rees; Lisa-Ann Gershwin

    2000-01-01

    Two species of hydromedusae, assumed to be native to the Black and Caspian Seas, were routinely collected in Suisun Slough, California, at the Suisun City Marina, during late summer and fall of 1997. Suisun Slough connects directly with Suisun Bay, part of the biologically complex and commercially important upper San Francisco Estuary, and with San Francisco Bay via San Pablo Bay. Maeotias marginata (Modeer 1791), has been previously reported (as M. inexspectata) from the Petaluma River, anot...

  7. Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia.

    Science.gov (United States)

    Armas, Aristides; Chen, Chen; Mims, Martha; Rivero, Gustavo

    2017-01-01

    Myelodysplastic syndrome (MDS) is cytogenetically heterogeneous and retains variable risk for acute myeloid leukemia transformation. Though not yet fully understood, there is an association between genetic abnormalities and defects in gene expression. The functional role for infrequent cytogenetic alteration remains unclear. An uncommon chromosomic abnormality is the presence of the Philadelphia (Ph) chromosome. Here, we report a patient with Ph+ MDS treated with low dose Dasatinib who achieved hematologic response for 7 months. In addition, we also examined the English literature on all de novo Ph + MDS cases between 1996 and 2015 to gain insight into clinical features and outcome.

  8. On the performance of de novo pathway enrichment

    DEFF Research Database (Denmark)

    Batra, Richa; Alcaraz, Nicolas; Gitzhofer, Kevin

    2017-01-01

    De novo pathway enrichment is a powerful approach to discover previously uncharacterized molecular mechanisms in addition to already known pathways. To achieve this, condition-specific functional modules are extracted from large interaction networks. Here, we give an overview of the state...... of the art and present the first framework for assessing the performance of existing methods. We identified 19 tools and selected seven representative candidates for a comparative analysis with more than 12,000 runs, spanning different biological networks, molecular profiles, and parameters. Our results show...

  9. Ecodesign: um novo paradigma moderno inscrito entre moda e consumo?

    OpenAIRE

    Andréia Mesacasa; Hieda Maria Pagliosa Corona; Nilvânia Aparecida Mello

    2010-01-01

    Este artigo pretende analisar as relações existentes entre a modernidade, a moda que rege as formas do vestir, o consumo evidenciado pela sociedade capitalista e suas implicações na prática do ecodesign que integra um novo paradigma no contexto vivenciado pelos indivíduos e a natureza. A modernidade possui como principais características a separação entre tempo-espaço, o desenvolvimento dos mecanismos de desencaixe e a apropriação reflexiva do conhecimento que desloca a vida social da fixidez...

  10. Ileus as first sign of de novo neuroendocrine prostate cancer

    DEFF Research Database (Denmark)

    Jochumsen, Mads Ryø; Sahlholdt, Bjørn Agerbo; Jensen, Jørgen Bjerggaard

    2017-01-01

    A 73-year-old man with almost no previous medical history was admitted acute with stomach pain, distended abdomen, stop of defecation and feculent vomiting. The patient had been constipated for three months and about a month before admission, a coloscopy was performed presenting no findings...... is more often seen as a result of treatment with hormone therapy. This case presents a rare debut symptom of a rare form of de novo cancer, illustrating the importance of a proper digital rectal examination when diagnosing constipation and acute abdomen....

  11. Perspective on Biotransformation and De Novo Biosynthesis of Licorice Constituents.

    Science.gov (United States)

    Zhao, Yujia; Lv, Bo; Feng, Xudong; Li, Chun

    2017-12-27

    Licorice, an important herbal medicine, is derived from the dried roots and rhizomes of Glycyrrhiza genus plants. It has been widely used in food, pharmaceutical, tobacco, and cosmetics industries with high economic value. However, overexploitation of licorice resources has severely destroyed the local ecology. Therefore, producing bioactive compounds of licorice through the biotransformation and bioengineering methods is a hot spot in recent years. In this perspective, we comprehensively summarize the biotransformation of licorice constituents into high-value-added derivatives by biocatalysts. Furthermore, successful cases and the strategies for de novo biosynthesizing compounds of licorice in microbes have been summarized. This paper will provide new insights for the further research of licorice.

  12. Perspectivas aos "novos designers de moda" no mercado de trabalho

    OpenAIRE

    Venturelli, Valéria Gomes Denelle

    2010-01-01

    Este trabalho tem como objetivo investigar os jovens que escolhem o curso de Negócios da Moda (com o foco em criação) na Universidade Anhembi Morumbi que conseguem trabalhar nessa área quando se formam e como é este processo. Sabemos que isto engloba entender de que forma a produção criativa desse novo designer de moda é assimilada pelo mercado de trabalho. Uma primeira entrevista foi realizada com o intuito de identificar o grupo de 33 alunos que optaram pelo curso de Negócios da Moda na Uni...

  13. Institución Educativa Técnica Francisco de Paula Santander de Galapa

    Directory of Open Access Journals (Sweden)

    Karolina Avendaño Sánchez

    2015-10-01

    Full Text Available La finalidad de este ensayo consiste en dar cuenta de datos significativos para conocer los hechos históricos que permitieron el surgimiento de la Institución Educativa Técnica Francisco de Paula Santander de Galapa (Colombia y, a través de estos, entender los elementos pedagógicos, curriculares, administrativos y locativos que la conforman en la actualidad. De esta manera será posible afrontar acertadamente los acontecimientos venideros.AbstractThis essay aims to report those meaningful data which allows us to have an insight into the historical facts that have led to the creation of the Technical Educational Institution Francisco de Paula Santander from Galapa; and through them, understand those pedagogical, curricular, administrative and locative elements which are made up of nowadays. In this way, it will be possible to face accurately the oncoming happenings.

  14. Migration and HIV Risk Among Men Who Have Sex With Men, San Francisco, 2011.

    Science.gov (United States)

    Lama, T T; Sudhinaraset, M; McFarland, W; Raymond, H F

    2015-12-01

    In San Francisco, MSM account for nearly 90% of HIV infections. Studies have postulated increased risk for HIV faced by MSM who migrate, particularly to urban environments, yet empirical data are lacking. In this study we analyzed data from the National HIV Behavioral Surveillance System collected in 2011 to ascertain whether nativity (U.S. versus foreign born) was associated with HIV prevalence, risk behavior, and service use. Among 510 MSM enrolled, HIV prevalence was 23.0%. Multivariable analyses demonstrate that while nativity was not associated with increased risk for HIV infection, those who had lived in San Francisco for more than five years had higher HIV prevalence compared to those who had lived for less than a year even after adjusting for age, race, income, education, and location of birth.

  15. Bartonella quintana in body lice and head lice from homeless persons, San Francisco, California, USA.

    Science.gov (United States)

    Bonilla, Denise L; Kabeya, Hidenori; Henn, Jennifer; Kramer, Vicki L; Kosoy, Michael Y

    2009-06-01

    Bartonella quintana is a bacterium that causes trench fever in humans. Past reports have shown Bartonella spp. infections in homeless populations in San Francisco, California, USA. The California Department of Public Health in collaboration with San Francisco Project Homeless Connect initiated a program in 2007 to collect lice from the homeless to test for B. quintana and to educate the homeless and their caregivers on prevention and control of louse-borne disease. During 2007-2008, 33.3% of body lice-infested persons and 25% of head lice-infested persons had lice pools infected with B. quintana strain Fuller. Further work is needed to examine how homeless persons acquire lice and determine the risk for illness to persons infested with B. quintana-infected lice.

  16. Evaluation of Nonpoint Source Pollution in Stormwater Run-Off in Neighborhoods in San Francisco, California

    Science.gov (United States)

    Bailey, C.; Bailey, E.; Cai, W.; Chen, K.; Duario, D.; Gonzalez, S.; Li, A.; Liu, L. W.; Matic, M.; Wu, M. L.; Wu, X. P.; Xie, J.; Yue, J.; Yuen, K.; Kirwin, J. P.; Neiss, J.

    2007-12-01

    This is the San Francisco Bay watershed encompasses 40% of California. When precipitation occurs, nonpoint source pollutants such as fertilizers, heavy metals, pesticides, gas and oil, enter the San Francisco Bay through this watershed. These pollutants contain dangerous chemicals that can potentially impact people and local ecology. The goal of Project Watershed is for high school students to design a study that investigates nonpoint source pollution in their own neighborhood and correlate these findings to the human activity in the neighborhood. Fifteen high school students participating in this study designed a stormwater collection devise that was installed in the public storm drain near each students home. Stormwater samples where collected from each device during the period of December 2006 to April 2007. Students assessed the samples for nitrates, heavy metals, oil and grease, total petroleum hydrocarbons, toluene and methyl tert-butyl ether (MTBE). This study outlines the methods students used to design the study and a summary of results found.

  17. [Historical notes on Infectious Diseases Hospital Francisco Javier Muñiz in Buenos Aires, Argentina].

    Science.gov (United States)

    Laval, Enrique

    2012-08-01

    The Infectious Diseases Hospital Francisco Javier Muñiz, Buenos Aires, Argentina, is the oldest in Latin America. It is over 100 years old and has a history worthy of pride. It became known as "Hospital of the pests" and was preceded by the old House of Insulation, which served as a quarantine station during epidemics of cholera, yellow fever and smallpox. The new House of Insulation, built in the neighborhood of Parque Patricios ("Barracks Hospital"), was renamed in 1904 in memory of Francisco Javier Muñiz, a former military doctor, naturalist and paleontologist. Its technical name is "Porteño Care Centre and National Reference Regional Infectious-Contagious Disease". It receives numerous national and foreign undergraduate and postgraduate students in its Departments of Infectious Diseases and Respiratory Diseases.

  18. The geotectonic evolution of southern part of Sao Francisco Craton, based in geochronologic interpretation

    International Nuclear Information System (INIS)

    Teixeira, W.

    1985-01-01

    Interpretation of available radiometric data from poly metamorphic terranes of southern part of the Sao Francisco Craton demonstrates the importance of geochronology as a tool in the study of ancient crustal evolution. In addition, radiometric study of basic intrusive magmatism helps define the most important epochs of crustal rifting during the Proterozoic. The definition of the southern border of the cratonic area based on distinctive age patterns of the geochronological provinces is also discussed. Finally, the geochronologic evolution of the Bambui platform cover is presented. Approximately 250 radiometric age determinations (Rb-Sr, K-Ar and Pb-Pb methods) were interpreted principally through the use of iso chronic diagrams. The geologic history tectonomagnetic events identified in this study is compared to the crustal evolution of similar segments of the Sao Francisco Craton and elsewhere. (author)

  19. Earthquakes and faults in the San Francisco Bay area (1970-2003)

    Science.gov (United States)

    Sleeter, Benjamin M.; Calzia, James P.; Walter, Stephen R.; Wong, Florence L.; Saucedo, George J.

    2004-01-01

    The map depicts both active and inactive faults and earthquakes magnitude 1.5 to 7.0 in the greater San Francisco Bay area. Twenty-two earthquakes magnitude 5.0 and greater are indicated on the map and listed chronologically in an accompanying table. The data are compiled from records from 1970-2003. The bathymetry was generated from a digital version of NOAA maps and hydrogeographic data for San Francisco Bay. Elevation data are from the USGS National Elevation Database. Landsat satellite image is from seven Landsat 7 Enhanced Thematic Mapper Plus scenes. Fault data are reproduced with permission from the California Geological Survey. The earthquake data are from the Northern California Earthquake Catalog.

  20. Food insecurity among homeless and marginally housed individuals living with HIV/AIDS in San Francisco.

    Science.gov (United States)

    Weiser, Sheri D; Bangsberg, David R; Kegeles, Susan; Ragland, Kathleen; Kushel, Margot B; Frongillo, Edward A

    2009-10-01

    Food insecurity is a risk factor for both HIV transmission and worse HIV clinical outcomes. We examined the prevalence of and factors associated with food insecurity among homeless and marginally housed HIV-infected individuals in San Francisco recruited from the Research on Access to Care in the Homeless Cohort. We used multiple logistic regression to determine socio-demographic and behavioral factors associated with food insecurity, which was measured using the Household Food Insecurity Access Scale. Among 250 participants, over half (53.6%) were food insecure. Higher odds of food insecurity was associated with being white, low CD4 counts, recent crack use, lack of health insurance, and worse physical and mental health. Food insecurity is highly prevalent among HIV-infected marginally housed individuals in San Francisco, and is associated with poor physical and mental health and poor social functioning. Screening for and addressing food insecurity should be a critical component of HIV prevention and treatment programs.

  1. Francisco Guerra (1916-2011), medical historian for the world and Puerto Rico.

    Science.gov (United States)

    Rigau-Pérez, José G

    2012-06-01

    This brief celebration of the work of Francisco Guerra (1916-2011) highlights his role as mentor for an international community, his study of local events in the context of global developments, and his contributions to the understanding of the medical history of Puerto Rico. A selective review of Francisco Guerra's methods and publications shows that his principal works are characterized by their vast scope and exhaustive coverage of ancient and modern published sources, coupled with clarity and conciseness of exposition. At least eight of his books (presented here) provide important information on events and personalities in Puerto Rico up to about 1940. Guerra, through his clinical experience, profound scholarship, and personal contacts, recovered the local medical developments of peripheral areas and incorporated them to a global context.

  2. O Rio São Francisco – Aspectos Geo-Humanos da Bacia

    Directory of Open Access Journals (Sweden)

    Armely Theresinha Maricato

    2014-05-01

    Full Text Available Trabalho foi desenvolvido durante a disciplina “Geografia do Brasil”, do curso de Geografia e História da PUCRS, ministrada pelo professor General Amyr Borges Fortes. Dividido em: Relações fisiográficas; Estudo étnico e histórico do Homem; Ambiente social; Distribuição da propriedade rural na Bacia do São Francisco; Cidades; Cultura.

  3. The tectonic evolution of Southern part of the Sao Francisco Craton

    International Nuclear Information System (INIS)

    Teixeira, W.

    1986-01-01

    The potentiality of geochronology when it is applied to the geologic context of craton basement of archean areas is shown. Samples from southern part of the Sao Francisco Craton, in Brazil, were collected for petrographic analysis and geochronological data interpretation. The set of radiometric determinations was obtained by K-Ar, Rb-Sr, Pb-Pb and U-Pb methods. (M.C.K.) [pt

  4. Transcendence and Son Jarocho as Practiced in the San Francisco Bay Area

    OpenAIRE

    Sacolick, Robin

    2016-01-01

    AbstractTranscendence and Son Jarocho as Practiced in the San Francisco Bay AreaRobin SacolickPeople of emerging or non-dominant ethnicities in multicultural, diasporic societies need ways to establish identities, merge strengths, and transcend difficulties. This study explores one way: community practices, by Latina/os and others in the Bay Area, of son jarocho, a centuries-old genre of Mexican music, dance and poetry. While their project revives traditional folklore, it also offers experien...

  5. Modified Mercalli intensities for some recent California earthquakes and historic San Francisco Bay Region earthquakes

    Science.gov (United States)

    Bakun, William H.

    1998-01-01

    Modified Mercalli Intensity (MMI) data for recent California earthquakes were used by Bakun and Wentworth (1997) to develop a strategy for bounding the location and moment magnitude M of earthquakes from MMI observations only. Bakun (Bull. Seismol. Soc. Amer., submitted) used the Bakun and Wentworth (1997) strategy to analyze 19th century and early 20th century San Francisco Bay Region earthquakes. The MMI data and site corrections used in these studies are listed in this Open-file Report. 

  6. Liminalidad social y negociación cultural: inmigrantes yucatecos en San Francisco, California

    Directory of Open Access Journals (Sweden)

    Inés Cornejo-Portugal

    2012-01-01

    Full Text Available Mediante los conceptos de liminalidad social y negociación cultural analizamos tres estudios de caso de yucatecos migrantes en San Francisco, California. Los migrantes estudiados dan cuenta de las diversas formas como utilizan los recursos sociales a los cuales tienen acceso (familiares, de creencia, de amistad y vecinales y que les permiten encontrar un equilibrio emocional relativo, frente a la tensión cultural de la sociedad destino.

  7. Observations of Fallout from the Fukushima Reactor Accident in San Francisco Bay Area Rainwater

    Science.gov (United States)

    Norman, Eric B.; Angell, Christopher T.; Chodash, Perry A.

    2011-01-01

    We have observed fallout from the recent Fukushima Dai-ichi reactor accident in samples of rainwater collected in the San Francisco Bay area. Gamma ray spectra measured from these samples show clear evidence of fission products – 131,132I, 132Te, and 134,137Cs. The activity levels we have measured for these isotopes are very low and pose no health risk to the public. PMID:21957447

  8. After the I-Hotel : Material, Cultural, and Affective Geographies of Filipino San Francisco

    OpenAIRE

    Tagle, Thea Quiray

    2015-01-01

    This dissertation traces the cultural and economic trajectories of Filipino migration to, settlement in, and displacement from the San Francisco Bay Area from the 1960s through the present moment as represented in the work of local poets, visual artists, and performers. After the I-Hotel argues that the shifting representations of urban and suburban space over this time period not only reveal the structural forces behind the displacement of old and new Filipino migrants in the Bay Area, but a...

  9. Groundwater quality in the North San Francisco Bay shallow aquifer, California

    Science.gov (United States)

    Bennett, George L.; Fram, Miranda S.

    2018-02-23

    Groundwater provides more than 40 percent of California’s drinking water. To protect this vital resource, the State of California created the Groundwater Ambient Monitoring and Assessment (GAMA) Program. The Priority Basin Project of the GAMA Program provides a comprehensive assessment of the State’s groundwater quality and increases public access to groundwater-quality information. The North San Francisco Bay Shallow Aquifer constitutes one of the study units being evaluated.

  10. What We Have Learned from San Francisco Declaration on Research Assessment and Leiden Manifesto?

    OpenAIRE

    Carey Ming-Li Chen; Wen-Yau Cathy Lin

    2017-01-01

    In recent years, the research performance evaluation of members of the academic community conducted by government or institutions has been applied with multiple indicators and peer review, however, there are many controversies about the design and application of research evaluation indicators. This article aims to introduce the development process of San Francisco Declaration on Research Assessment (DORA) and Leiden Manifesto and summarize their contents of guidelines and attempts to compare ...

  11. Global Health Diplomacy, "San Francisco Values," and HIV/AIDS: From the Local to the Global.

    Science.gov (United States)

    Kevany, Sebastian

    2015-01-01

    San Francisco has a distinguished history as a cosmopolitan, progressive, and international city, including extensive associations with global health. These circumstances have contributed to new, interdisciplinary scholarship in the field of global health diplomacy (GHD). In the present review, we describe the evolution and history of GHD at the practical and theoretical levels within the San Francisco medical community, trace related associations between the local and the global, and propose a range of potential opportunities for further development of this dynamic field. We provide a historical overview of the development of the "San Francisco Model" of collaborative, community-owned HIV/AIDS treatment and care programs as pioneered under the "Ward 86" paradigm of the 1980s. We traced the expansion and evolution of this model to the national level under the Ryan White Care Act, and internationally via the President's Emergency Plan for AIDS Relief. In parallel, we describe the evolution of global health diplomacy practices, from the local to the global, including the integration of GHD principles into intervention design to ensure social, political, and cultural acceptability and sensitivity. Global health programs, as informed by lessons learned from the San Francisco Model, are increasingly aligned with diplomatic principles and practices. This awareness has aided implementation, allowed policymakers to pursue related and progressive social and humanitarian issues in conjunction with medical responses, and elevated global health to the realm of "high politics." In the 21st century, the integration between diplomatic, medical, and global health practices will continue under "smart global health" and GHD paradigms. These approaches will enhance intervention cost-effectiveness by addressing and optimizing, in tandem with each other, a wide range of (health and non-health) foreign policy, diplomatic, security, and economic priorities in a synergistic manner

  12. Hazard-evaluation and technical-assistance report HETA 90-122-l2073, technical assistance to San Francisco General Hospital and Medical Center, San Francisco, California

    Energy Technology Data Exchange (ETDEWEB)

    Moss, C.E.; Seitz, T.

    1990-10-01

    In response to a request from the Director of the Environmental Health and Safety Department of the San Francisco General Hospital and Medical Center, located in San Francisco, California, an evaluation was undertaken of possible hazardous working conditions at that site. Concern existed about exposures to hazards while operating the germicidal lamp at the facility. Germicidal lamps were used to disinfect the air in tuberculosis and aerosolized pentamidine clinics. The workers wore no protective eye wear. All rooms used a 30 watt germicidal lamp. Lower wattage bulbs in the smaller rooms would have reduced occupational ultraviolet (UV) exposure. Reflectance levels of UV radiation were quite high and varied. Worker exposure to germicidal lamp UV levels was dependent on many factors, some of the most important ones being the position of the bulb in the room, age of the bulb, obstruction of the UV radiation by objects near the bulb, and the height of the worker. While there are no consensus guidelines available on ventilation systems designed for areas where germicidal lamps are used, the provision of good room air distribution and mixing is recommended to prevent stagnant air conditions or short circuiting of supply air within the room. Bulb changers need to be aware of the need for protective clothing and gloves for protection from both the UV radiation levels as well as possible glass breakage.

  13. Map showing thickness of young bay mud, southern San Francisco Bay, California

    Science.gov (United States)

    McDonald, Sandra D.; Nichols, Donald R.; Wright, Nancy A.; Atwater, Brian

    1978-01-01

    Soft water-saturated estuarine deposits less than 10,000 years old underlie the southern part of San Francisco bay and the present and former marshlands that border the bay. Known locally as bay mud or as young bay mud, these deposits, and the estuarine environment that produces them, are of major importance in making decision on land use and development in the San Francisco Bay area. Knowledge of the distribution, thickness, and physical properties of young bay mud is critical to the feasibility, design, and maintenance of structures built on it. Fore this reason, numerous attempts have been made in the past to map or describe these characteristics (Mitchell, 1963; Goldman, 1969; McDonald and Nichols, 1974). The accompanying map of bay-mud thickness significantly revises part of an earlier compilation by Kahle and Goldman (1969) and includes new data from approximately 2400 boreholes, most of which have been drilled during the past 15 years. It also incorporates information on historic margins of San Francisco Bay and its tidal marshes (Nichols and Wright, 1971). Although this map was compelled mostly from data gathered during foundation investigations and construction projects, it is mostly from data gathered during foundation investigations and construction projects, it is not a substitute for such studies. Rather, the map provides regional information for land-use planning, seismic zonation, and design of foundation investigations.

  14. When bohemia becomes a business: City lights, Columbus avenue and a future for San Francisco

    Directory of Open Access Journals (Sweden)

    Tara Brabazon

    2011-05-01

    Full Text Available This article offers a study of the now clichéd Bohemian Index. I explore how Richard Florida’s arguments flatten, homogenize and commercialize the radicalism and resistance of the cities validated through his criteria. Activism becomes a brand. San Francisco is important in such research because of its political and literary history, with North Beach’s iconography tethered to the Beat Generation. The best known ‘Left Coast City’ in the world, San Francisco reveals the political paradoxes of creative industries and the city imaging literature. Bohemia creates an attractive city of coffee and conversation. San Francisco is a diverse economy, with developed service, tourist and hospitality industries. It is facing seismic challenges, as is the home state. In a credit crunch, the economies based around lifestyle capitalism and service industries suffer as international infrastructural and public sector funding retracts. My article proposes no causal relationship between bohemia and economic development through either tourism or the creative industries. Instead, the complexity of ‘Bohemia’ as a concept, trope and brand is revealed, spilling beyond the seemingly predictable, mappable and trackable Bohemian Index.

  15. Helminth fauna parasitizing Pimelodus pohli (Actinopterygii: Pimelodidae from the upper São Francisco River, Brazil

    Directory of Open Access Journals (Sweden)

    Claudia Silveira São Sabas

    Full Text Available The parasite fauna of catfish, Pimelodus pohli, from the São Francisco River Basin is presented. A total of 45 catfish from the upper São Francisco River (45°15′44″W 18°13′25″S, were examined from July 2009 to September 2011. Forty-three catfish (95.5% were infected by at least one parasite species, with 885 parasite specimens being found, distributed across 17 species: Monogenea (Demidospermus uncusvalidus, Pavanelliella pavanellii, and Scleroductus sp.; Eucestoda (plerocercoids of Proteocephalidea; Digenea (metacercariae of Austrodiplostomum compactum, adults of Auriculostoma platense and Kalipharynx sp., and juvenile of Prosthenhystera obesa; Nematoda (larvae of Contracaecum sp., Hysterothylacium sp., Procamallanus pimelodus, Procamallanus sp., and unidentified of Cucullanidae, and adults of Cucullanus caballeroi, Philometra sp., and Procamallanus freitasi; and Acanthocephala (adults of Neoechinorhynchus pimelodi. Procamallanus freitasi and Scleroductus sp. were the taxa with the highest prevalence. Demidospermus uncusvalidus, P. freitasi, and Scleroductus sp. were the dominant species. The host's sex did not influence parasitic indexes; however, the total length of the catfish did appear to have some influence. The parasites, with except for P. obesa, were registered for the first time in P. pohli, as well as the occurrence of Kalipharynx sp. and C. caballeroi among pimelodid hosts from São Francisco River and South America.

  16. Helminth fauna parasitizing Pimelodus pohli (Actinopterygii: Pimelodidae) from the upper São Francisco River, Brazil.

    Science.gov (United States)

    Sabas, Claudia Silveira São; Brasil-Sato, Marilia Carvalho

    2014-01-01

    The parasite fauna of catfish, Pimelodus pohli, from the São Francisco River Basin is presented. A total of 45 catfish from the upper São Francisco River (45°15'44″W 18°13'25″S), were examined from July 2009 to September 2011. Forty-three catfish (95.5%) were infected by at least one parasite species, with 885 parasite specimens being found, distributed across 17 species: Monogenea (Demidospermus uncusvalidus, Pavanelliella pavanellii, and Scleroductus sp.); Eucestoda (plerocercoids of Proteocephalidea); Digenea (metacercariae of Austrodiplostomum compactum, adults of Auriculostoma platense and Kalipharynx sp., and juvenile of Prosthenhystera obesa); Nematoda (larvae of Contracaecum sp., Hysterothylacium sp., Procamallanus pimelodus, Procamallanus sp., and unidentified of Cucullanidae, and adults of Cucullanus caballeroi, Philometra sp., and Procamallanus freitasi); and Acanthocephala (adults of Neoechinorhynchus pimelodi). Procamallanus freitasi and Scleroductus sp. were the taxa with the highest prevalence. Demidospermus uncusvalidus, P. freitasi, and Scleroductus sp. were the dominant species. The host's sex did not influence parasitic indexes; however, the total length of the catfish did appear to have some influence. The parasites, with except for P. obesa, were registered for the first time in P. pohli, as well as the occurrence of Kalipharynx sp. and C. caballeroi among pimelodid hosts from São Francisco River and South America.

  17. A new species of Hisonotus (Siluriformes, Loricariidae from rio São Francisco basin, Brazil

    Directory of Open Access Journals (Sweden)

    Fábio Roxo

    2015-04-01

    Full Text Available A new species of Hisonotus is described from the rio São Francisco basin. The new species can be distinguished from congeners by having (1 a unique coloration pattern of caudal fin with one black spot extending from its origin to the ventral lobe and two dark spots at the end of the lobe’s rays; (2 odontodes forming longitudinally aligned rows on head and trunk; (3 a functional V-shaped spinelet; (4 a single rostral plate at the tip of the snout; (5 by lacking contrasting dark geometric spots on the anterodorsal region of the body; (6 a lower caudal-peduncle depth; and (7 lower counts of the lateral median plates and (8 higher premaxillary and dentary teeth. The new species is the second described species of the genus Hisonotus in the rio São Francisco basin. It was found inhabiting the marginal vegetation of the rio São Francisco and three of its tributary, rio das Velhas, rio Paraopeba and rio Formoso.

  18. Abordagem racional no planejamento de novos tuberculostáticos: inibidores da InhA, enoil-ACP redutase do M. tuberculosis Rational approach in the new antituberculosis agent design: inhibitors of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis

    Directory of Open Access Journals (Sweden)

    Carolina Horta Andrade

    2008-06-01

    Full Text Available Associada à disseminação da infecção causada pelo HIV, a tuberculose (TB é considerada, atualmente, problema mundial de saúde pública devido às proporções que vem assumindo. A resistência micobacteriana aos fármacos utilizados na terapêutica é a principal causa da reincidência da TB. Diante deste quadro alarmante, o desenvolvimento de novos e seletivos fármacos anti-TB se faz urgente e necessário. A biossíntese de ácidos graxos é um processo bioquímico realizado por procariotos e eucariotos, o qual fornece precursores essenciais à montagem de componentes celulares importantes, tais como fosfolipídeos, lipoproteínas, lipopolissacarídeos, ácidos micólicos e envelope celular. As diferenças bioquímicas e funcionais entre o mecanismo biossintético de ácidos graxos em bactérias e mamíferos tornam-no alvo relevante ao planejamento de novos antibacterianos, mais seletivos e menos tóxicos. As enoil-ACP redutases são enzimas cruciais à etapa de alongamento de ácidos graxos, considerados produtos intermediários na biossíntese de ácidos micólicos - os principais componentes da parede celular micobacteriana. Portanto, tais enzimas são tidas como alvos moleculares no planejamento racional de novos tuberculostáticos. Avanços recentes no processo de descoberta de novos agentes anti-TB, particularmente os inibidores da enoil-ACP redutase, serão discutidos nesta revisão.In conjunction with the spread of HIV infection, tuberculosis (TB has been among the worldwide health threats. Mycobacteria resistance to the drugs currently used in the therapeutics is the main cause of TB resurgence. In view of this severe situation, the new and selective anti-TB design is of utmost importance. Fatty acid biosynthesis is a prokariontes and eucariontes biochemical process that supplies essential precursors for the assembly of important cellular components, such as phospholipids, lipoproteins, lipopolysaccharides, mycolic acids and

  19. De novo assembly and transcriptome analysis of contrasting sugarcane varieties.

    Directory of Open Access Journals (Sweden)

    Claudio Benicio Cardoso-Silva

    Full Text Available Sugarcane is an important crop and a major source of sugar and alcohol. In this study, we performed de novo assembly and transcriptome annotation for six sugarcane genotypes involved in bi-parental crosses. The de novo assembly of the sugarcane transcriptome was performed using short reads generated using the Illumina RNA-Seq platform. We produced more than 400 million reads, which were assembled into 72,269 unigenes. Based on a similarity search, the unigenes showed significant similarity to more than 28,788 sorghum proteins, including a set of 5,272 unigenes that are not present in the public sugarcane EST databases; many of these unigenes are likely putative undescribed sugarcane genes. From this collection of unigenes, a large number of molecular markers were identified, including 5,106 simple sequence repeats (SSRs and 708,125 single-nucleotide polymorphisms (SNPs. This new dataset will be a useful resource for future genetic and genomic studies in this species.

  20. Novo-desenvolvimento, capital social e desigualdade social

    Directory of Open Access Journals (Sweden)

    Ana Cristina de Oliveira Oliveira

    2012-03-01

    Full Text Available Este artigo aborda a tendência de enfrentamento da desigualdade social a partir, no campo econômico, da versão do novo-desenvolvimentismo e, no campo político e ideológico, a partir da noção de capital social, na tentativa de realizar um "capitalismo com face mais humana". Discutiremos duas ordens de questões, considerando a especificidade da formação social brasileira de capitalismo dependente: 1 a “construção de Estados fortes” para

    assegurar as condições de acumulação do capital, ampliando as margens do mercado de consumo, aliviando a pobreza e controlando possíveis tensões políticas e 2 a difusão da necessidade de construir uma sociedade em harmonia, que se traduz na incorporação da ética empreendedora dos empresários em todas as esferas sociais. Entendemos que este escopo político-econômico revela uma nova pedagogia da hegemonia, sustentada numa suposta alternativa
    de gerenciamento das novas expressões da “questão social”, voltada para educar o conformismo e ocultar o conflito de classes.
    Palavras-chave:  questão social; novo-desenvolvimentismo; capital social; inclusão forçada

  1. Multi-nucleotide de novo Mutations in Humans.

    Directory of Open Access Journals (Sweden)

    Søren Besenbacher

    2016-11-01

    Full Text Available Mutation of the DNA molecule is one of the most fundamental processes in biology. In this study, we use 283 parent-offspring trios to estimate the rate of mutation for both single nucleotide variants (SNVs and short length variants (indels in humans and examine the mutation process. We found 17812 SNVs, corresponding to a mutation rate of 1.29 × 10-8 per position per generation (PPPG and 1282 indels corresponding to a rate of 9.29 × 10-10 PPPG. We estimate that around 3% of human de novo SNVs are part of a multi-nucleotide mutation (MNM, with 558 (3.1% of mutations positioned less than 20kb from another mutation in the same individual (median distance of 525bp. The rate of de novo mutations is greater in late replicating regions (p = 8.29 × 10-19 and nearer recombination events (p = 0.0038 than elsewhere in the genome.

  2. A simple method suitable to study de novo root organogenesis

    Directory of Open Access Journals (Sweden)

    Xiaodong eChen

    2014-05-01

    Full Text Available De novo root organogenesis is the process in which adventitious roots regenerate from detached or wounded plant tissues or organs. In tissue culture, appropriate types and concentrations of plant hormones in the medium are critical for inducing adventitious roots. However, in natural conditions, regeneration from detached organs is likely to rely on endogenous hormones. To investigate the actions of endogenous hormones and the molecular mechanisms guiding de novo root organogenesis, we developed a simple method to imitate natural conditions for adventitious root formation by culturing Arabidopsis thaliana leaf explants on B5 medium without additive hormones. Here we show that the ability of the leaf explants to regenerate roots depends on the age of the leaf and on certain nutrients in the medium. Based on these observations, we provide examples of how this method can be used in different situations, and how it can be optimized. This simple method could be used to investigate the effects of various physiological and molecular changes on the regeneration of adventitious roots. It is also useful for tracing cell lineage during the regeneration process by differential interference contrast observation of -glucuronidase staining, and by live imaging of proteins labeled with fluorescent tags.

  3. Molecular characterization of de novo secondary trisomy 13

    Energy Technology Data Exchange (ETDEWEB)

    Shaffer, L.G.; McCaskill, C.; Han, Jin-Yeong [Baylor College of Medicine, Houston, TX (United States); Choo, K.H.A. [Murdoch Institute, Melbourne (Australia); Cutillo, D.M.; Donnenfeld, A.E. [Pennyslvania Hospital, PA (United States); Weiss, L.; Van Dyke, D.L. [Henry Ford Hospital, Detroit, MI (United States)

    1994-11-01

    Unbalanced Robertsonian translocations are a significant cause of mental retardation and fetal wastage. The majority of homologous rearrangements of chromosome 21 in Down syndrome have been shown to be isochromosomes. Aside from chromosome 21, very little is known about other acrocentric homologous rearrangements. In this study, four cases of de novo secondary trisomy 13 are presented. FISH using alpha-satellite sequences, rDNA, and a pTRI-6 satellite I sequence specific to the short arm of chromosome 13 showed all four rearrangements to be dicentric an apparently devoid of ribosomal genes. Three of four rearrangements retained the pTRI-6 satellite I sequence. Case 1 was the exception, showing a deletion of this sequence in the rearrangement, although both parental chromosomes 13 had strong positive hybridization signals. Eleven microsatellite markers from chromosome 13 were also used to characterize the rearrangements. Of the four possible outcomes, one maternal Robertsonian translocation, two paternal isochromosomes, and one maternal isochromosomes were observed. A double recombination was observed in the maternally derived rob(13q13q). No recombination events were detected in any isochromosome. The parental origins and molecular chromosomal structure of these cases are compared with previous studies of de novo acrocentric rearrangements. 20 refs., 3 figs., 2 tabs.

  4. Origins of De Novo Genes in Human and Chimpanzee.

    Science.gov (United States)

    Ruiz-Orera, Jorge; Hernandez-Rodriguez, Jessica; Chiva, Cristina; Sabidó, Eduard; Kondova, Ivanela; Bontrop, Ronald; Marqués-Bonet, Tomàs; Albà, M Mar

    2015-12-01

    The birth of new genes is an important motor of evolutionary innovation. Whereas many new genes arise by gene duplication, others originate at genomic regions that did not contain any genes or gene copies. Some of these newly expressed genes may acquire coding or non-coding functions and be preserved by natural selection. However, it is yet unclear which is the prevalence and underlying mechanisms of de novo gene emergence. In order to obtain a comprehensive view of this process, we have performed in-depth sequencing of the transcriptomes of four mammalian species--human, chimpanzee, macaque, and mouse--and subsequently compared the assembled transcripts and the corresponding syntenic genomic regions. This has resulted in the identification of over five thousand new multiexonic transcriptional events in human and/or chimpanzee that are not observed in the rest of species. Using comparative genomics, we show that the expression of these transcripts is associated with the gain of regulatory motifs upstream of the transcription start site (TSS) and of U1 snRNP sites downstream of the TSS. In general, these transcripts show little evidence of purifying selection, suggesting that many of them are not functional. However, we find signatures of selection in a subset of de novo genes which have evidence of protein translation. Taken together, the data support a model in which frequently-occurring new transcriptional events in the genome provide the raw material for the evolution of new proteins.

  5. De Novo Mutations in EBF3 Cause a Neurodevelopmental Syndrome.

    Science.gov (United States)

    Sleven, Hannah; Welsh, Seth J; Yu, Jing; Churchill, Mair E A; Wright, Caroline F; Henderson, Alex; Horvath, Rita; Rankin, Julia; Vogt, Julie; Magee, Alex; McConnell, Vivienne; Green, Andrew; King, Mary D; Cox, Helen; Armstrong, Linlea; Lehman, Anna; Nelson, Tanya N; Williams, Jonathan; Clouston, Penny; Hagman, James; Németh, Andrea H

    2017-01-05

    Early B cell factor 3 (EBF3) is an atypical transcription factor that is thought to influence the laminar formation of the cerebral cortex. Here, we report that de novo mutations in EBF3 cause a complex neurodevelopmental syndrome. The mutations were identified in two large-scale sequencing projects: the UK Deciphering Developmental Disorders (DDD) study and the Canadian Clinical Assessment of the Utility of Sequencing and Evaluation as a Service (CAUSES) study. The core phenotype includes moderate to severe intellectual disability, and many individuals exhibit cerebellar ataxia, subtle facial dysmorphism, strabismus, and vesicoureteric reflux, suggesting that EBF3 has a widespread developmental role. Pathogenic de novo variants identified in EBF3 include multiple loss-of-function and missense mutations. Structural modeling suggested that the missense mutations affect DNA binding. Functional analysis of mutant proteins with missense substitutions revealed reduced transcriptional activities and abilities to form heterodimers with wild-type EBF3. We conclude that EBF3, a transcription factor previously unknown to be associated with human disease, is important for brain and other organ development and warrants further investigation. Copyright © 2017 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  6. De Novo Synthesis of Steroids and Oxysterols in Adipocytes*

    Science.gov (United States)

    Li, Jiehan; Daly, Edward; Campioli, Enrico; Wabitsch, Martin; Papadopoulos, Vassilios

    2014-01-01

    Local production and action of cholesterol metabolites such as steroids or oxysterols within endocrine tissues are currently recognized as an important principle in the cell type- and tissue-specific regulation of hormone effects. In adipocytes, one of the most abundant endocrine cells in the human body, the de novo production of steroids or oxysterols from cholesterol has not been examined. Here, we demonstrate that essential components of cholesterol transport and metabolism machinery in the initial steps of steroid and/or oxysterol biosynthesis pathways are present and active in adipocytes. The ability of adipocyte CYP11A1 in producing pregnenolone is demonstrated for the first time, rendering adipocyte a steroidogenic cell. The oxysterol 27-hydroxycholesterol (27HC), synthesized by the mitochondrial enzyme CYP27A1, was identified as one of the major de novo adipocyte products from cholesterol and its precursor mevalonate. Inhibition of CYP27A1 activity or knockdown and deletion of the Cyp27a1 gene induced adipocyte differentiation, suggesting a paracrine or autocrine biological significance for the adipocyte-derived 27HC. These findings suggest that the presence of the 27HC biosynthesis pathway in adipocytes may represent a defense mechanism to prevent the formation of new fat cells upon overfeeding with dietary cholesterol. PMID:24280213

  7. De novo synthesis of steroids and oxysterols in adipocytes.

    Science.gov (United States)

    Li, Jiehan; Daly, Edward; Campioli, Enrico; Wabitsch, Martin; Papadopoulos, Vassilios

    2014-01-10

    Local production and action of cholesterol metabolites such as steroids or oxysterols within endocrine tissues are currently recognized as an important principle in the cell type- and tissue-specific regulation of hormone effects. In adipocytes, one of the most abundant endocrine cells in the human body, the de novo production of steroids or oxysterols from cholesterol has not been examined. Here, we demonstrate that essential components of cholesterol transport and metabolism machinery in the initial steps of steroid and/or oxysterol biosynthesis pathways are present and active in adipocytes. The ability of adipocyte CYP11A1 in producing pregnenolone is demonstrated for the first time, rendering adipocyte a steroidogenic cell. The oxysterol 27-hydroxycholesterol (27HC), synthesized by the mitochondrial enzyme CYP27A1, was identified as one of the major de novo adipocyte products from cholesterol and its precursor mevalonate. Inhibition of CYP27A1 activity or knockdown and deletion of the Cyp27a1 gene induced adipocyte differentiation, suggesting a paracrine or autocrine biological significance for the adipocyte-derived 27HC. These findings suggest that the presence of the 27HC biosynthesis pathway in adipocytes may represent a defense mechanism to prevent the formation of new fat cells upon overfeeding with dietary cholesterol.

  8. Anthropogenic influence on recent bathymetric change in west-central San Francisco Bay

    Science.gov (United States)

    Barnard, Patrick L.; Kvitek, Rikk G.

    2010-01-01

    Two multibeam sonar surveys of west-central San Francisco Bay, California, were conducted in 1997 and 2008. Bathymetric change analysis between the two surveys indicates a loss of 14.1 million cubic meters (-3.1 cm/yr-1) of sediment during this time period, representing an approximately three-fold acceleration of the rate that was observed from prior depth change analysis from 1947 to 1979 for all of Central Bay, using more spatially coarse National Ocean Service (NOS) soundings. The portions of the overlapping survey areas between 1997 and 2008 designated as aggregate mining lease sites lost sediment at five times the rate of the remainder of west-central San Francisco Bay. Despite covering only 28% of the analysis area, volume change within leasing areas accounted for 9.2 million cubic meters of sediment loss, while the rest of the area lost 4.9 million cubic meters of sediment. The uncertainty of this recent analysis is more tightly constrained due to more stringent controls on vertical and horizontal position via tightly coupled, inertially aided differential Global Positioning Systems (GPS) solutions for survey vessel trajectory that virtually eliminate inaccuracies from traditional tide modeling and vessel motion artifacts. Further, quantification of systematic depth measurement error can now be calculated through comparison of static surfaces (e.g., bedrock) between surveys using seafloor habitat maps based on acoustic backscatter measurements and ground-truthing with grab samples and underwater video. Sediment loss in the entire San Francisco Bay Coastal System during the last half-century,as estimated from a series of bathymetric change studies, is 240 million cubic meters, and most of this is believed to be coarse sediment (i.e., sand and gravel) from Central Bay and the San Francisco Bar, which is likely to limit the sand supply to adjacent, open-coast beaches. This hypothesis is supported by a calibrated numerical model in a related study that indicates

  9. Materiais avançados: novos produtos e novos processos na indústria automobilística

    Directory of Open Access Journals (Sweden)

    Heloisa V. de Medina

    1998-06-01

    Full Text Available Esse artigo mostra o desenvolvimento recente dos materiais novos e avançados e seus impactos na organização insustrial exigindo flexibilidade em todas as fases: P&D, projeto e produção. Essas mudanças estão gerando produtos novos e melhorados e atendendo também aos requisitos ambientais. Discute-se o conceito de materiais avançados e apresenta-se os desenvolvimentos recentes nesse campo. O desenvolvimento de materiais especiais para o setor automobilístico é também enfatizado como exemplo significativo da revolução dos materiais e seus impactos inovadores na estrutura industrial deste setor vital.This article shows the recent development of new and advanced materials and its impatcs on the industrial organization, asking for flexiblility from the R&D through the design fase until the production level. These changes are enabling new and better products and also meeting environmental requirements. The concept of advanced material is discussed and the recent progresses on materials field are presented.. The development of special materials and its new applications in the automotive industry is also stressed as a significant exemple of the materials revolution and its innovative impacts on the industrial structure of this core sector.

  10. Waterbird nest monitoring program in San Francisco Bay (2005-10)

    Science.gov (United States)

    Ackerman, Joshua T.; Herzog, Mark P.

    2012-01-01

    Historically, Forster’s Terns (Sterna forsteri), American Avocets (Recurvirostra americana), and Black-necked Stilts (Himantopus mexicanus) were uncommon residents of San Francisco Bay, California (Grinnell and others, 1918; Grinnell and Wythe, 1927; Sibley, 1952). Presently, however, avocets and stilts are the two most abundant breeding shorebirds in San Francisco Bay (Stenzel and others, 2002; Rintoul and others, 2003). More than 4,000 avocets and 1,000 stilts, roughly 20 percent of their San Francisco Bay wintering populations, breed within the estuary, making San Francisco Bay the largest breeding area for these species on the Pacific Coast (Stenzel and others, 2002; Rintoul and others, 2003). Forster’s Terns were first observed breeding in the San Francisco Bay in 1948 (110 nests); they had increased to over 4000 individuals by the 1980s (Sibley, 1952; Gill, 1977; Harvey and others, 1992; Carter and others, 1990) and were estimated at 2000–3000 for 1998–2002; (Strong and others, 2004).It is hypothesized that the relatively large size of the current waterbird breeding populations is a result of the creation of artificial salt evaporation ponds from the 1930s through the 1950s (Gill, 1977; Goals Project, 1999). Until recently, these salt ponds and associated islands used by waterbirds for nesting have been managed relatively similarly and have supported large breeding waterbird populations. Recently, the South Bay Salt Pond Restoration Project has implemented plans to convert 50–90 percent of the 15,000 acres of salt ponds in the South San Francisco Bay back to tidal marsh habitat. Therefore, there is concern that the Restoration Project, while benefiting other native species, could negatively influence local breeding populations of waterbirds that are reliant on salt pond habitats for both breeding and foraging. A primary goal of the South Bay Salt Pond Restoration Project is to maintain current breeding waterbird populations (South Bay Salt Pond Long

  11. A distribuição das transferências, público-alvo e cobertura do Benefício de Prestação Continuada = The Distribution of transfers, target-group and coverage of the Continuous Cash Benefit

    Directory of Open Access Journals (Sweden)

    Medeiros, Marcelo

    2009-01-01

    Full Text Available O artigo propõe uma nova definição operacional de deficiência e uma metodologia de cálculo para estimar as distribuições de pessoas idosas e deficientes incapazes para o trabalho e vida independente, dos benefícios e dos níveis de cobertura do Benefício de Prestação Continuada (BPC, segundo diferentes estratos de renda da população brasileira. São usados dados do Censo 2000, da Pnad 2006 e de registros administrativos do MDS. A estimativa indica que a população de idosos e deficientes incapazes distribui-se uniformemente nos estratos de renda, mas os benefícios são distribuídos predominantemente nos grupos de renda mais baixa da população, com a cobertura maior entre os mais pobres. Os resultados sugerem que a cobertura da população-alvo ainda é insuficiente e que o programa apresenta erros de focalização, mas estes são, em sua maioria, de baixa intensidade

  12. De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

    DEFF Research Database (Denmark)

    Hamilton, P J; Campbell, N G; Sharma, S

    2013-01-01

    De novo genetic variation is an important class of risk factors for autism spectrum disorder (ASD). Recently, whole-exome sequencing of ASD families has identified a novel de novo missense mutation in the human dopamine (DA) transporter (hDAT) gene, which results in a Thr to Met substitution...

  13. 76 FR 68767 - Draft Guidance for Industry and Food and Drug Administration Staff; De Novo Classification...

    Science.gov (United States)

    2011-11-07

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-D-0689] Draft Guidance for Industry and Food and Drug Administration Staff; De Novo Classification Process... for Industry and Food and Drug Administration Staff; De Novo Classification Process (Evaluation of...

  14. De novo assembly of human genomes with massively parallel short read sequencing

    DEFF Research Database (Denmark)

    Li, Ruiqiang; Zhu, Hongmei; Ruan, Jue

    2010-01-01

    Next-generation massively parallel DNA sequencing technologies provide ultrahigh throughput at a substantially lower unit data cost; however, the data are very short read length sequences, making de novo assembly extremely challenging. Here, we describe a novel method for de novo assembly of larg...

  15. De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies

    DEFF Research Database (Denmark)

    2014-01-01

    analyzed exome-sequencing data of 356 trios with the "classical" epileptic encephalopathies, infantile spasms and Lennox Gastaut syndrome, including 264 trios previously analyzed by the Epi4K/EPGP consortium. In this expanded cohort, we find 429 de novo mutations, including de novo mutations in DNM1...

  16. Genes from scratch--the evolutionary fate of de novo genes.

    Science.gov (United States)

    Schlötterer, Christian

    2015-04-01

    Although considered an extremely unlikely event, many genes emerge from previously noncoding genomic regions. This review covers the entire life cycle of such de novo genes. Two competing hypotheses about the process of de novo gene birth are discussed as well as the high death rate of de novo genes. Despite the high death rate, some de novo genes are retained and remain functional, even in distantly related species, through their integration into gene networks. Further studies combining gene expression with ribosome profiling in multiple populations across different species will be instrumental for an improved understanding of the evolutionary processes operating on de novo genes. Copyright © 2015 The Author. Published by Elsevier Ltd.. All rights reserved.

  17. De Novo duplication in Charcot-Marie-Tooth Type 1A

    Energy Technology Data Exchange (ETDEWEB)

    Mandich, P.; Bellone, E.; Ajmar, F. [and others

    1996-09-01

    We read with interest the paper on {open_quotes}Prevalence and Origin of De Novo Duplications in Charcot-Marie-Tooth Disease Type 1A: First Report of a De Novo Duplication with a Maternal Origin,{close_quotes}. They reported their experience with 10 sporadic cases of Charcot-Marie-Tooth type 1A (CMT1A) in which it was demonstrated that the disease had arisen as the result of a de novo duplication. They analyzed the de novo-duplication families by using microsatellite markers and identified the parental origin of the duplication in eight cases. In one family the duplication was of maternal origin, whereas in the remaining seven cases it was of paternal origin. The authors concluded that their report was the first evidence of a de novo duplication of maternal origin, suggesting that this is not a phenomenon associated solely with male meiosis. 7 refs.

  18. FSG: Fast String Graph Construction for De Novo Assembly.

    Science.gov (United States)

    Bonizzoni, Paola; Vedova, Gianluca Della; Pirola, Yuri; Previtali, Marco; Rizzi, Raffaella

    2017-10-01

    The string graph for a collection of next-generation reads is a lossless data representation that is fundamental for de novo assemblers based on the overlap-layout-consensus paradigm. In this article, we explore a novel approach to compute the string graph, based on the FM-index and Burrows and Wheeler Transform. We describe a simple algorithm that uses only the FM-index representation of the collection of reads to construct the string graph, without accessing the input reads. Our algorithm has been integrated into the string graph assembler (SGA) as a standalone module to construct the string graph. The new integrated assembler has been assessed on a standard benchmark, showing that fast string graph (FSG) is significantly faster than SGA while maintaining a moderate use of main memory, and showing practical advantages in running FSG on multiple threads. Moreover, we have studied the effect of coverage rates on the running times.

  19. De novo artistic activity following insular-SII ischemia.

    Science.gov (United States)

    Thomas-Anterion, Catherine; Creac'h, Christelle; Dionet, Elsa; Borg, Céline; Extier, Chantal; Faillenot, Isabelle; Peyron, Roland

    2010-07-01

    We report here the case of a female patient who developed the following behavioural changes after a brain lesion involving the left posterior insula and SII cortices. She discovered de novo artistic capabilities for painting, with an episodic and compulsive need to paint ("hyperpainting"), but also exhibited changes in her ability to feel emotions. In addition, she had a typical neuropathic pain syndrome, including provoked pain and spontaneous pain, whose intensity was worsened when she painted with cold colours. This case-report suggests some kind of synaesthesiae, which has previously been reported for other sensory modalities. These findings suggest that a cross-talk between emotional, thermosensory, pain, and motivational functions may take place during recovery, at the level of the left insular-SII cortices. Copyright 2010. Published by Elsevier B.V.

  20. Katome: de novo DNA assembler implemented in rust

    Science.gov (United States)

    Neumann, Łukasz; Nowak, Robert M.; Kuśmirek, Wiktor

    2017-08-01

    Katome is a new de novo sequence assembler written in the Rust programming language, designed with respect to future parallelization of the algorithms, run time and memory usage optimization. The application uses new algorithms for the correct assembly of repetitive sequences. Performance and quality tests were performed on various data, comparing the new application to `dnaasm', `ABySS' and `Velvet' genome assemblers. Quality tests indicate that the new assembler creates more contigs than well-established solutions, but the contigs have better quality with regard to mismatches per 100kbp and indels per 100kbp. Additionally, benchmarks indicate that the Rust-based implementation outperforms `dnaasm', `ABySS' and `Velvet' assemblers, written in C++, in terms of assembly time. Lower memory usage in comparison to `dnaasm' is observed.

  1. De novo development of artistic creativity in Alzheimer's disease

    Science.gov (United States)

    Chakravarty, Ambar

    2011-01-01

    The case of an 82-year-old female with probable Alzheimer's disease (AD), who developed unusual artistic creativity after development of her disease, is described. The possible pathogenetic mechanism is discussed. The patient showed no inclination toward visual arts during her premorbid years. However, 4 years after development of AD suggestive symptoms she started painting beautiful pictures rather impulsively. Some such paintings have been appreciated even by a qualified art expert. Such de novo development of artistic creativity had been described earlier in subjects with the semantic form of fronto-temporal dementia (FTD), but not in AD. The prevailing concept of lateralized compromise and paradoxical functional facilitation, proposed in connection with FTD subjects, may not be applicable in AD subjects where the affection is more diffuse and more posterior in the brain. Hence, the likely pathogenetic mechanism involved in the case described may remain uncertain. Possibilities are discussed. PMID:22346020

  2. De novo SOX11 mutations cause Coffin-Siris syndrome.

    Science.gov (United States)

    Tsurusaki, Yoshinori; Koshimizu, Eriko; Ohashi, Hirofumi; Phadke, Shubha; Kou, Ikuyo; Shiina, Masaaki; Suzuki, Toshifumi; Okamoto, Nobuhiko; Imamura, Shintaro; Yamashita, Michiaki; Watanabe, Satoshi; Yoshiura, Koh-ichiro; Kodera, Hirofumi; Miyatake, Satoko; Nakashima, Mitsuko; Saitsu, Hirotomo; Ogata, Kazuhiro; Ikegawa, Shiro; Miyake, Noriko; Matsumoto, Naomichi

    2014-06-02

    Coffin-Siris syndrome (CSS) is a congenital disorder characterized by growth deficiency, intellectual disability, microcephaly, characteristic facial features and hypoplastic nails of the fifth fingers and/or toes. We previously identified mutations in five genes encoding subunits of the BAF complex, in 55% of CSS patients. Here we perform whole-exome sequencing in additional CSS patients, identifying de novo SOX11 mutations in two patients with a mild CSS phenotype. sox11a/b knockdown in zebrafish causes brain abnormalities, potentially explaining the brain phenotype of CSS. SOX11 is the downstream transcriptional factor of the PAX6-BAF complex, highlighting the importance of the BAF complex and SOX11 transcriptional network in brain development.

  3. Herpes simplex virus 1 induces de novo phospholipid synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Sutter, Esther [Electron Microscopy, Institute of Veterinary Anatomy, University of Zuerich (Switzerland); Oliveira, Anna Paula de; Tobler, Kurt [Electron microscopy, Institute of Virology, University of Zuerich (Switzerland); Schraner, Elisabeth M. [Electron Microscopy, Institute of Veterinary Anatomy, University of Zuerich (Switzerland); Sonda, Sabrina [Institute of Parasitology, University of Zuerich (Switzerland); Kaech, Andres [Center for Microscopy and Image Analysis, University of Zuerich (Switzerland); Lucas, Miriam S. [Electron Microscopy ETH Zuerich (EMEZ), Swiss Federal Institute of Technology, Zuerich (Switzerland); Ackermann, Mathias [Electron microscopy, Institute of Virology, University of Zuerich (Switzerland); Wild, Peter, E-mail: pewild@access.uzh.ch [Electron Microscopy, Institute of Veterinary Anatomy, University of Zuerich (Switzerland)

    2012-08-01

    Herpes simplex virus type 1 capsids bud at nuclear membranes and Golgi membranes acquiring an envelope composed of phospholipids. Hence, we measured incorporation of phospholipid precursors into these membranes, and quantified changes in size of cellular compartments by morphometric analysis. Incorporation of [{sup 3}H]-choline into both nuclear and cytoplasmic membranes was significantly enhanced upon infection. [{sup 3}H]-choline was also part of isolated virions even grown in the presence of brefeldin A. Nuclei expanded early in infection. The Golgi complex and vacuoles increased substantially whereas the endoplasmic reticulum enlarged only temporarily. The data suggest that HSV-1 stimulates phospholipid synthesis, and that de novo synthesized phospholipids are inserted into nuclear and cytoplasmic membranes to i) maintain membrane integrity in the course of nuclear and cellular expansion, ii) to supply membrane constituents for envelopment of capsids by budding at nuclear membranes and Golgi membranes, and iii) to provide membranes for formation of transport vacuoles.

  4. De-novo design of antimicrobial peptides for plant protection.

    Directory of Open Access Journals (Sweden)

    Benjamin Zeitler

    Full Text Available This work describes the de-novo design of peptides that inhibit a broad range of plant pathogens. Four structurally different groups of peptides were developed that differ in size and position of their charged and hydrophobic clusters and were assayed for their ability to inhibit bacterial growth and fungal spore germination. Several peptides are highly active at concentrations between 0,1 and 1 µg/ml against plant pathogenic bacteria, such as Pseudomonas syringae, Pectobacterium carotovorum, and Xanthomonas vesicatoria. Importantly, no hemolytic activity could be detected for these peptides at concentrations up to 200 µg/ml. Moreover, the peptides are also active after spraying on the plant surface demonstrating a possible way of application. In sum, our designed peptides represent new antimicrobial agents and with the increasing demand for antimicrobial compounds for production of "healthy" food, these peptides might serve as templates for novel antibacterial and antifungal agents.

  5. De novo synthesis of a sunscreen compound in vertebrates.

    Science.gov (United States)

    Osborn, Andrew R; Almabruk, Khaled H; Holzwarth, Garrett; Asamizu, Shumpei; LaDu, Jane; Kean, Kelsey M; Karplus, P Andrew; Tanguay, Robert L; Bakalinsky, Alan T; Mahmud, Taifo

    2015-05-12

    Ultraviolet-protective compounds, such as mycosporine-like amino acids (MAAs) and related gadusols produced by some bacteria, fungi, algae, and marine invertebrates, are critical for the survival of reef-building corals and other marine organisms exposed to high-solar irradiance. These compounds have also been found in marine fish, where their accumulation is thought to be of dietary or symbiont origin. In this study, we report the unexpected discovery that fish can synthesize gadusol de novo and that the analogous pathways are also present in amphibians, reptiles, and birds. Furthermore, we demonstrate that engineered yeast containing the fish genes can produce and secrete gadusol. The discovery of the gadusol pathway in vertebrates provides a platform for understanding its role in these animals, and the possibility of engineering yeast to efficiently produce a natural sunscreen and antioxidant presents an avenue for its large-scale production for possible use in pharmaceuticals and cosmetics.

  6. De novo assembly of a haplotype-resolved human genome.

    Science.gov (United States)

    Cao, Hongzhi; Wu, Honglong; Luo, Ruibang; Huang, Shujia; Sun, Yuhui; Tong, Xin; Xie, Yinlong; Liu, Binghang; Yang, Hailong; Zheng, Hancheng; Li, Jian; Li, Bo; Wang, Yu; Yang, Fang; Sun, Peng; Liu, Siyang; Gao, Peng; Huang, Haodong; Sun, Jing; Chen, Dan; He, Guangzhu; Huang, Weihua; Huang, Zheng; Li, Yue; Tellier, Laurent C A M; Liu, Xiao; Feng, Qiang; Xu, Xun; Zhang, Xiuqing; Bolund, Lars; Krogh, Anders; Kristiansen, Karsten; Drmanac, Radoje; Drmanac, Snezana; Nielsen, Rasmus; Li, Songgang; Wang, Jian; Yang, Huanming; Li, Yingrui; Wong, Gane Ka-Shu; Wang, Jun

    2015-06-01

    The human genome is diploid, and knowledge of the variants on each chromosome is important for the interpretation of genomic information. Here we report the assembly of a haplotype-resolved diploid genome without using a reference genome. Our pipeline relies on fosmid pooling together with whole-genome shotgun strategies, based solely on next-generation sequencing and hierarchical assembly methods. We applied our sequencing method to the genome of an Asian individual and generated a 5.15-Gb assembled genome with a haplotype N50 of 484 kb. Our analysis identified previously undetected indels and 7.49 Mb of novel coding sequences that could not be aligned to the human reference genome, which include at least six predicted genes. This haplotype-resolved genome represents the most complete de novo human genome assembly to date. Application of our approach to identify individual haplotype differences should aid in translating genotypes to phenotypes for the development of personalized medicine.

  7. De novo assembly of a haplotype-resolved human genome

    DEFF Research Database (Denmark)

    Cao, Hongzhi; Wu, Honglong; Luo, Ruibang

    2015-01-01

    The human genome is diploid, and knowledge of the variants on each chromosome is important for the interpretation of genomic information. Here we report the assembly of a haplotype-resolved diploid genome without using a reference genome. Our pipeline relies on fosmid pooling together with whole-genome...... of novel coding sequences that could not be aligned to the human reference genome, which include at least six predicted genes. This haplotype-resolved genome represents the most complete de novo human genome assembly to date. Application of our approach to identify individual haplotype differences should...... shotgun strategies, based solely on next-generation sequencing and hierarchical assembly methods. We applied our sequencing method to the genome of an Asian individual and generated a 5.15-Gb assembled genome with a haplotype N50 of 484 kb. Our analysis identified previously undetected indels and 7.49 Mb...

  8. Novo teste para diagnóstico das afasias

    Directory of Open Access Journals (Sweden)

    José G. Albernaz

    1953-06-01

    Full Text Available Um novo teste para diagnóstico e contrôle do tratamento das diferentes formas de afasia, especialmente adaptado para a língua portuguêsa, é apresentado e descrito em detalhe. O teste, que será de valor para clínicos e psicólogos interessados no tratamento e reabilitação de pacientes afásicos, se executa em cêrca de 30 minutos, interpreta-se fàcilmente e fornece os elementos necessários para o planejamento da reeducação da linguagem. Além disso, a repetição do teste de tempos em tempos indicará os progressos do paciente e sugerirá modificações do plano de tratamento no momento oportuno.

  9. Application of Generative Autoencoder in De Novo Molecular Design.

    Science.gov (United States)

    Blaschke, Thomas; Olivecrona, Marcus; Engkvist, Ola; Bajorath, Jürgen; Chen, Hongming

    2018-01-01

    A major challenge in computational chemistry is the generation of novel molecular structures with desirable pharmacological and physiochemical properties. In this work, we investigate the potential use of autoencoder, a deep learning methodology, for de novo molecular design. Various generative autoencoders were used to map molecule structures into a continuous latent space and vice versa and their performance as structure generator was assessed. Our results show that the latent space preserves chemical similarity principle and thus can be used for the generation of analogue structures. Furthermore, the latent space created by autoencoders were searched systematically to generate novel compounds with predicted activity against dopamine receptor type 2 and compounds similar to known active compounds not included in the trainings set were identified. © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  10. Accurate de novo design of hyperstable constrained peptides

    Energy Technology Data Exchange (ETDEWEB)

    Bhardwaj, Gaurav; Mulligan, Vikram Khipple; Bahl, Christopher D.; Gilmore, Jason M.; Harvey, Peta J.; Cheneval, Olivier; Buchko, Garry W.; Pulavarti, Surya V. S. R. K.; Kaas, Quentin; Eletsky, Alexander; Huang, Po-Ssu; Johnsen, William A.; Greisen, Per Jr; Rocklin, Gabriel J.; Song, Yifan; Linsky, Thomas W.; Watkins, Andrew; Rettie, Stephen A.; Xu, Xianzhong; Carter, Lauren P.; Bonneau, Richard; Olson, James M.; Coutsias, Evangelos; Correnti, Colin E.; Szyperski, Thomas; Craik, David J.; Baker, David

    2016-09-14

    Covalently-crosslinked peptides present attractive opportunities for developing new therapeutics. Lying between small molecule and protein therapeutics in size, natural crosslinked peptides play critical roles in signaling, virulence and immunity. Engineering novel peptides with precise control over their three-dimensional structures is a significant challenge. Here we describe the development of computational methods for de novo design of conformationally-restricted peptides, and the use of these methods to design hyperstable disulfide-stabilized miniproteins, heterochiral peptides, and N-C cyclic peptides. Experimentally-determined X-ray and NMR structures for 12 of the designs are nearly identical to the computational models. The computational design methods and stable scaffolds provide the basis for a new generation of peptide-based drugs.

  11. De novo identification of viral pathogens from cell culture hologenomes

    Directory of Open Access Journals (Sweden)

    Patowary Ashok

    2012-01-01

    Full Text Available Abstract Background Fast, specific identification and surveillance of pathogens is the cornerstone of any outbreak response system, especially in the case of emerging infectious diseases and viral epidemics. This process is generally tedious and time-consuming thus making it ineffective in traditional settings. The added complexity in these situations is the non-availability of pure isolates of pathogens as they are present as mixed genomes or hologenomes. Next-generation sequencing approaches offer an attractive solution in this scenario as it provides adequate depth of sequencing at fast and affordable costs, apart from making it possible to decipher complex interactions between genomes at a scale that was not possible before. The widespread application of next-generation sequencing in this field has been limited by the non-availability of an efficient computational pipeline to systematically analyze data to delineate pathogen genomes from mixed population of genomes or hologenomes. Findings We applied next-generation sequencing on a sample containing mixed population of genomes from an epidemic with appropriate processing and enrichment. The data was analyzed using an extensive computational pipeline involving mapping to reference genome sets and de-novo assembly. In depth analysis of the data generated revealed the presence of sequences corresponding to Japanese encephalitis virus. The genome of the virus was also independently de-novo assembled. The presence of the virus was in addition, verified using standard molecular biology techniques. Conclusions Our approach can accurately identify causative pathogens from cell culture hologenome samples containing mixed population of genomes and in principle can be applied to patient hologenome samples without any background information. This methodology could be widely applied to identify and isolate pathogen genomes and understand their genomic variability during outbreaks.

  12. Physicochemical investigation of medieval ceramics from excavation site Novo Brdo

    Directory of Open Access Journals (Sweden)

    Čugalj Snežana S.

    2008-01-01

    Full Text Available Artefacts produced or treated at high temperatures provide information about manufacturing techniques. Well preserved ceramic objects are therefore excellent chronological markers as well as general markers of society development. In order to determine provenance of pottery fragments, archaeologists classify samples according to their physical characteristics, decoration and aesthetic style. However, a more objective multidisciplinary approach, based on undoubted results, is necessary to complete this study. In this work we have investigated 27 samples of medieval ceramics from excavation site Novo Brdo, using X-ray fluorescence (XRF, FTIR spectroscopy and X-ray powder diffraction (XRPD. Novo Brdo was large and rich mining and trading center of Serbia in XIV and XV century. A large number of ceramic samples found during the systematic excavation of this archaeological site allow good choice of samples for both destructive and nondestructive analysis. Combining results obtained by different experimental techniques, i.e. by FT-IR spectroscopy, after deconvolution of the spectra, and XRPD analysis, we have determined mineralogical composition and technology of production of investigated pottery. Estimated temperature of firing ranged from 800 to 900 °C, which is in agreement with the presence of high-temperature minerals like gehlenite and anorthite. Firing was preformed in the oxidation atmosphere since hematite, which is formed only in oxidation atmosphere, is detected in all investigated samples. Cross sections showed presence of defects and inhomogeneity of investigated ceramic, which indicates fast and incomplete firing procedure. All these findings indicate that investigated pottery was produced in the domestic workshops. The obtained results will be used to build up the National database for medieval ceramics as well as the database for the Balkan region.

  13. The limits of de novo DNA motif discovery.

    Directory of Open Access Journals (Sweden)

    David Simcha

    Full Text Available A major challenge in molecular biology is reverse-engineering the cis-regulatory logic that plays a major role in the control of gene expression. This program includes searching through DNA sequences to identify "motifs" that serve as the binding sites for transcription factors or, more generally, are predictive of gene expression across cellular conditions. Several approaches have been proposed for de novo motif discovery-searching sequences without prior knowledge of binding sites or nucleotide patterns. However, unbiased validation is not straightforward. We consider two approaches to unbiased validation of discovered motifs: testing the statistical significance of a motif using a DNA "background" sequence model to represent the null hypothesis and measuring performance in predicting membership in gene clusters. We demonstrate that the background models typically used are "too null," resulting in overly optimistic assessments of significance, and argue that performance in predicting TF binding or expression patterns from DNA motifs should be assessed by held-out data, as in predictive learning. Applying this criterion to common motif discovery methods resulted in universally poor performance, although there is a marked improvement when motifs are statistically significant against real background sequences. Moreover, on synthetic data where "ground truth" is known, discriminative performance of all algorithms is far below the theoretical upper bound, with pronounced "over-fitting" in training. A key conclusion from this work is that the failure of de novo discovery approaches to accurately identify motifs is basically due to statistical intractability resulting from the fixed size of co-regulated gene clusters, and thus such failures do not necessarily provide evidence that unfound motifs are not active biologically. Consequently, the use of prior knowledge to enhance motif discovery is not just advantageous but necessary. An implementation of

  14. Congenital cataracts: de novo gene conversion event in CRYBB2.

    Science.gov (United States)

    Garnai, Sarah J; Huyghe, Jeroen R; Reed, David M; Scott, Kathleen M; Liebmann, Jeffrey M; Boehnke, Michael; Richards, Julia E; Ritch, Robert; Pawar, Hemant

    2014-01-01

    To identify the cause of congenital cataracts in a consanguineous family of Ashkenazi Jewish ancestry. We performed genome-wide linkage analysis and whole-exome sequencing for the initial discovery of variants, and we confirmed the variants using gene-specific primers and Sanger sequencing. We found significant evidence of linkage to chromosome 22, under an autosomal dominant inheritance model, with a maximum logarithm of the odds (LOD) score of 3.91 (16.918 to 25.641 Mb). Exome sequencing identified three nonsynonymous changes in the CRYBB2 exon 5 coding sequence that are consistent with the sequence of the corresponding region of the pseudogene CRYBB2P1. The identification of these changes was complicated by possible mismapping of some mutated CRYBB2 sequences to CRYBB2P1. Sequencing with gene-specific primers confirmed that the changes--rs2330991, c.433 C>T (p.R145W); rs2330992, c.440A>G (p.Q147R); and rs4049504, c.449C>T (p.T150M)--present in all ten affected family members are located in CRYBB2 and are not artifacts of cross-reaction with CRYBB2P1. We did not find these changes in six unaffected family members, including the unaffected grandfather who contributed the affected haplotype, nor did we find them in the 100 Ashkenazi Jewish controls. Our data are consistent with a de novo gene conversion event, transferring 270 base pairs at most from CRYBB2P1 to exon 5 of CRYBB2. This study highlights how linkage mapping can be complicated by de novo mutation events, as well as how sequence-analysis pipeline mapping of short reads from next-generation sequencing can be complicated by the existence of pseudogenes or other highly homologous sequences.

  15. De novo GABRG2 mutations associated with epileptic encephalopathies

    Science.gov (United States)

    Shen, Dingding; Hernandez, Ciria C; Shen, Wangzhen; Hu, Ningning; Poduri, Annapurna; Shiedley, Beth; Rotenberg, Alex; Datta, Alexandre N; Leiz, Steffen; Patzer, Steffi; Boor, Rainer; Ramsey, Kerri; Goldberg, Ethan; Helbig, Ingo; Ortiz-Gonzalez, Xilma R; Lemke, Johannes R; Marsh, Eric D; Macdonald, Robert L

    2017-01-01

    Abstract Epileptic encephalopathies are a devastating group of severe childhood onset epilepsies with medication-resistant seizures and poor developmental outcomes. Many epileptic encephalopathies have a genetic aetiology and are often associated with de novo mutations in genes mediating synaptic transmission, including GABAA receptor subunit genes. Recently, we performed next generation sequencing on patients with a spectrum of epileptic encephalopathy phenotypes, and we identified five novel (A106T, I107T, P282S, R323W and F343L) and one known (R323Q) de novo GABRG2 pathogenic variants (mutations) in eight patients. To gain insight into the molecular basis for how these mutations contribute to epileptic encephalopathies, we compared the effects of the mutations on the properties of recombinant α1β2γ2L GABAA receptors transiently expressed in HEK293T cells. Using a combination of patch clamp recording, immunoblotting, confocal imaging and structural modelling, we characterized the effects of these GABRG2 mutations on GABAA receptor biogenesis and channel function. Compared with wild-type α1β2γ2L receptors, GABAA receptors containing a mutant γ2 subunit had reduced cell surface expression with altered subunit stoichiometry or decreased GABA-evoked whole-cell current amplitudes, but with different levels of reduction. While a causal role of these mutations cannot be established directly from these results, the functional analysis together with the genetic information suggests that these GABRG2 variants may be major contributors to the epileptic encephalopathy phenotypes. Our study further expands the GABRG2 phenotypic spectrum and supports growing evidence that defects in GABAergic neurotransmission participate in the pathogenesis of genetic epilepsies including epileptic encephalopathies. PMID:27864268

  16. Factors Associated With Ambulatory Activity in De Novo Parkinson Disease.

    Science.gov (United States)

    Christiansen, Cory; Moore, Charity; Schenkman, Margaret; Kluger, Benzi; Kohrt, Wendy; Delitto, Anthony; Berman, Brian; Hall, Deborah; Josbeno, Deborah; Poon, Cynthia; Robichaud, Julie; Wellington, Toby; Jain, Samay; Comella, Cynthia; Corcos, Daniel; Melanson, Ed

    2017-04-01

    Objective ambulatory activity during daily living has not been characterized for people with Parkinson disease prior to initiation of dopaminergic medication. Our goal was to characterize ambulatory activity based on average daily step count and examine determinants of step count in nonexercising people with de novo Parkinson disease. We analyzed baseline data from a randomized controlled trial, which excluded people performing regular endurance exercise. Of 128 eligible participants (mean ± SD = 64.3 ± 8.6 years), 113 had complete accelerometer data, which were used to determine daily step count. Multiple linear regression was used to identify factors associated with average daily step count over 10 days. Candidate explanatory variable categories were (1) demographics/anthropometrics, (2) Parkinson disease characteristics, (3) motor symptom severity, (4) nonmotor and behavioral characteristics, (5) comorbidities, and (6) cardiorespiratory fitness. Average daily step count was 5362 ± 2890 steps per day. Five factors explained 24% of daily step count variability, with higher step count associated with higher cardiorespiratory fitness (10%), no fear/worry of falling (5%), lower motor severity examination score (4%), more recent time since Parkinson disease diagnosis (3%), and the presence of a cardiovascular condition (2%). Daily step count in nonexercising people recruited for this intervention trial with de novo Parkinson disease approached sedentary lifestyle levels. Further study is warranted for elucidating factors explaining ambulatory activity, particularly cardiorespiratory fitness, and fear/worry of falling. Clinicians should consider the costs and benefits of exercise and activity behavior interventions immediately after diagnosis of Parkinson disease to attenuate the health consequences of low daily step count.Video Abstract available for more insights from the authors (see Video, Supplemental Digital Content 1, http://links.lww.com/JNPT/A170).

  17. Usinas Hidrelétricas Reversíveis Sazonais no Rio São Francisco: aumentando o armazenamento energético e diminuindo a evaporação

    Directory of Open Access Journals (Sweden)

    Julian David Hunt

    2016-12-01

    Full Text Available A bacia hidrográfica do Rio São Francisco tem grande importância para o país não apenas pelo volume de água transportado em uma região semiárida, mas também pelo potencial hídrico passível de aproveitamento energético e abastecimento hídrico da região Nordeste. Um desafio na gestão de seus recursos hídricos é a perda de água por evaporação no Reservatório de Sobradinho. Esse artigo propõe a aplicação de um novo esquema de armazenamento energético o qual combina Usinas Hidrelétricas Reversíveis Sazonais (UHRS com hidrelétricas em cascata, com o intuito de aumentar a capacidade de armazenamento hídrico e energético do Brasil e diminuir a evaporação no Reservatório de Sobradinho. A proposta UHRS Muquém tem potencial de aumentar a capacidade de armazenamento energético do SIN em 4,8%, gerar eletricidade durante o horário de ponta e armazenar a geração elétrica das fontes eólica e solar.

  18. When it happens again: impact of future San Francisco Bay area earthquakes

    Science.gov (United States)

    Zoback, M.; Boatwright, J.; Kornfield, L.; Scawthorn, C.; Rojahn, C.

    2005-12-01

    San Francisco Bay area earthquakes, like major floods and hurricanes, have the potential for massive damage to dense urban population centers concentrated in vulnerable zones-along active faults, in coastal regions, and along major river arteries. The recent destruction of Hurricane Katrina does have precedent in the destruction following the 1906 "San Francisco" earthquake and fire in which more than 3000 people were killed and 225,000 were left homeless in San Francisco alone, a city of 400,000 at the time. Analysis of a comprehensive set of damage reports from the magnitude (M) 7.9 1906 earthquake indicates a region of ~ 18,000 km2 was subjected to shaking of Modified Mercalli Intensity of VIII or more - motions capable of damaging even modern, well-built structures; more than 60,000 km2 was subjected to shaking of Intensity VII or greater - the threshold for damage to masonry and poorly designed structures. By comparison, Katrina's hurricane force winds and intense rainfall impacted an area of ~100,000 km2 on the Gulf Coast. Thus, the anticipated effects of a future major Bay Area quake to lives, property, and infrastructure are comparable in scale to Katrina. Secondary hazards (levee failure and flooding in the case of Katrina and fire following the 1906 earthquake) greatly compounded the devastation in both disasters. A recent USGS-led study concluded there is a 62% chance of one or more damaging (M6.7 or greater) earthquakes striking the greater San Francisco Bay area over the next 30 years. The USGS prepared HAZUS loss estimates for the 10 most likely forecast earthquakes which range in size from a M6.7 event on a blind thrust to the largest anticipated event, a M7.9 repeat of the 1906 earthquake. The largest economic loss is expected for a repeat of the 1906 quake. Losses in the Bay region for this event are nearly double those predicted for a M6.9 rupture of the entire Hayward Fault in the East Bay. However, because of high density of population along the

  19. Knowledge, Indications and Willingness to Take Pre-Exposure Prophylaxis among Transwomen in San Francisco, 2013.

    Directory of Open Access Journals (Sweden)

    Erin C Wilson

    Full Text Available Safe and effective HIV prevention strategies are needed for transwomen. Transwomen in the US have a 34 times greater odds of being infected with HIV than all adults age 15-49, and in San Francisco, California 42.4% of transwomen are estimated to be infected with HIV. Pre-exposure prophylaxis (PrEP is the first biomedical intervention with promise for reducing HIV acquisition in transwomen. However, little is known about whether transwomen know about PrEP, are taking PrEP and would be good candidates for PrEP based on their risk profile and behaviors. A population-based dataset was analyzed to determine how many transwomen in San Francisco knew about PrEP by the end of 2013 - more than a year after iPrex results demonstrated efficacy of PrEP in preventing HIV. We found that of 233 transwomen, only 13.7% had heard of PrEP. Transwomen who were living with HIV compared to those who were HIV-negative, and those who recently injected drugs compared to non-injection drug users were more likely to have heard of PrEP. Based on CDC guidelines for PrEP among MSM and IDU, 45 (30.2% transwomen of the 149 HIV-negative transwomen in the sample were candidates for PrEP. This estimate based on CDC criteria is arguably low. Given that almost half of transwomen in San Francisco are living with HIV, this findings points to a need for further consideration of PrEP criteria that are specific and tailored to the risks for HIV faced by transwomen that are different from MSM and injection drug users. Research to scale up access and test the effectiveness of PrEP for transwomen is also urgently needed.

  20. Seroadaptive behaviours among men who have sex with men in San Francisco: the situation in 2008.

    Science.gov (United States)

    Snowden, Jonathan M; Raymond, H Fisher; McFarland, Willi

    2011-03-01

    To assess changes in seroadaptive behaviours among men who have sex with men (MSM) in San Francisco over the past 4 years. 461 MSM were recruited in 2008 as the second wave of the US National HIV Behavioural Surveillance (NHBS) survey in San Francisco. Participants were classified into patterns of seroadaptive behaviours based on reported sexual practices (ie, episodes of insertive and receptive anal sex), condom use, HIV serostatus and partners' serostatus for up to five partners in the preceding 6 months. The prevalence of seroadaptive behaviours was compared with the first wave of NHBS, which used identical methods in 2004. In 2008, 33.7% of HIV-negative and 18.9% of HIV-positive MSM used condoms 100% of the time; nearly half (48.0%) of HIV-negative MSM and two-thirds (66.7%) of HIV-positive MSM had unprotected anal intercourse (UAI). Collectively, seroadaptive behaviours comprised the most common form of risk management; 40.5% of HIV-negative MSM and 51.1% of HIV-positive MSM engaged in some form of seroadaptation, the most common being 'pure serosorting' (all UAI with same serostatus partners) reported by 27.5% of HIV-negative MSM and 22.2% of HIV-positive MSM. None of these behaviours were significantly different from their corresponding measures in 2004. Seroadaptation continues to describe the prevailing form of sexual risk management for MSM in San Francisco, suggesting that these behaviours are not novel and require careful measurement to gauge the true potential for the spread of HIV, and nuanced prevention messages to reduce risk.

  1. Space use and habitat selection of migrant and resident American Avocets in San Francisco Bay

    Science.gov (United States)

    Demers, Scott A.; Takekawa, John Y.; Ackerman, Joshua T.; Warnock, N.; Athearn, N.D.

    2010-01-01

    San Francisco Bay is a wintering area for shorebirds, including American Avocets (Recurvirostra americana). Recently, a new resident population of avocets has emerged, presumably because of the development of tidal marshes into salt-evaporation ponds. In habitat restoration now underway, as many as 90% of salt ponds will be restored to tidal marsh. However, it is unknown if wintering and resident avocets coexist and if their requirements for space and habitat differ, necessitating different management for their populations to be maintained during restoration. We captured and radio-marked wintering avocets at a salt pond and a tidal flat to determine their population status (migrant or resident) and examine their space use and habitat selection. Of the radio-marked avocets, 79% were migrants and 21% were residents. At the salt pond, residents' fidelity to their location of capture was higher, and residents moved less than did migrants from the same site. Conversely, on the tidal flat, fidelity of residents to their site of capture was lower, and residents' home ranges were larger than those of migrants from the same site. Habitat selection of migrants and residents differed little; however, capture site influenced habitat selection far more than the birds' status as migrants or residents. Our study suggests that individual avocets have high site fidelity while wintering in San Francisco Bay, although the avocet as a species is plastic in its space use and habitat selection. This plasticity may allow wintering migrant and resident avocets to adapt to habitat change in San Francisco Bay. ?? The Cooper Ornithological Society 2010.

  2. Clams as CO2 generators: The Potamocorbula amurensis example in San Francisco Bay

    Science.gov (United States)

    Chauvaud, Laurent; Thompson, Janet K.; Cloern, James E.; Thouzeau, Gerard

    2003-01-01

    Respiration and calcium carbonate production by the invasive Asian clam, Potamocorbula amurensis, were calculated to assess their importance as CO2 sources in northern San Francisco Bay. Production, calculated using monthly population density and size structure measured at three sites over 7 yr and a shell length/CaCO3 conversion factor, averaged 221 (6184) g CaCO3 m22 yr21 . Net calcium carbonate production by this exotic bivalve releases CO2 at a mean rate of 18 (617) g C m22 yr21 . Respiration by P. amurensis, estimated from secondary production, releases additional CO2 at a mean rate of 37 (634) g C m22 yr21 . Therefore, total net CO2 production by P. amurensis averages 55 (651) g C m22 yr21 in an estuarine domain where net primary production consumes only 20 g inorganic C m22 yr21 . CO2 production by P. amurensis in northern San Francisco Bay is an underestimate of the total CO2 supply from the calcified zoobenthic communities of San Francisco Bay, and results from other studies have suggested that this rate is not unusual for temperate estuaries. Global extrapolation yields a gross CO2 production rate in the world’s estuaries of 1 3 1014 g C yr21 , which suggests that calcified benthic organisms in estuaries generate CO2 equal in magnitude to the CO2 emissions from the world’s lakes or from planetary volcanism (the net source is determined by the highly variable rate of CO2 consumption by carbonate dissolution). This biogenic CO2 source is increasing because of the continuing global translocation of mollusks and their successful colonization of new habitats.

  3. A Tidally Averaged Sediment-Transport Model for San Francisco Bay, California

    Science.gov (United States)

    Lionberger, Megan A.; Schoellhamer, David H.

    2009-01-01

    A tidally averaged sediment-transport model of San Francisco Bay was incorporated into a tidally averaged salinity box model previously developed and calibrated using salinity, a conservative tracer (Uncles and Peterson, 1995; Knowles, 1996). The Bay is represented in the model by 50 segments composed of two layers: one representing the channel (>5-meter depth) and the other the shallows (0- to 5-meter depth). Calculations are made using a daily time step and simulations can be made on the decadal time scale. The sediment-transport model includes an erosion-deposition algorithm, a bed-sediment algorithm, and sediment boundary conditions. Erosion and deposition of bed sediments are calculated explicitly, and suspended sediment is transported by implicitly solving the advection-dispersion equation. The bed-sediment model simulates the increase in bed strength with depth, owing to consolidation of fine sediments that make up San Francisco Bay mud. The model is calibrated to either net sedimentation calculated from bathymetric-change data or measured suspended-sediment concentration. Specified boundary conditions are the tributary fluxes of suspended sediment and suspended-sediment concentration in the Pacific Ocean. Results of model calibration and validation show that the model simulates the trends in suspended-sediment concentration associated with tidal fluctuations, residual velocity, and wind stress well, although the spring neap tidal suspended-sediment concentration variability was consistently underestimated. Model validation also showed poor simulation of seasonal sediment pulses from the Sacramento-San Joaquin River Delta at Point San Pablo because the pulses enter the Bay over only a few days and the fate of the pulses is determined by intra-tidal deposition and resuspension that are not included in this tidally averaged model. The model was calibrated to net-basin sedimentation to calculate budgets of sediment and sediment-associated contaminants. While

  4. Monitoring of water in soil in asparagus irrigated culture in Vale do Sao Francisco, Pernambuco, Brazil

    International Nuclear Information System (INIS)

    Antonino, Antonio C. Dantas; Sampaio, Everardo V.S.B.; Dall' Ollio, Attilio; Bernardo, Ana L. Alves; Audry, Pierre

    1996-08-01

    For many years the brazilian government has inactivated the implantation of irrigated areas in the Sao Francisco valley, obtaining high productivity.After the most appropriated areas having been occupied, the irrigation of second choice soils, usually more shallower and more clay is been tried. In one of these areas, the productivity of asparagus is less than the expected. trying to improve productivity by optimization of irrigation, the movement of water on soil and plants is being monitored far the last year and a half. the main results are shown with emphasis on the raining season, the most problematic

  5. Arquetipos femeninos en las obras de Francisco Umbral y Mario Vargas Llosa

    OpenAIRE

    Godoy Cossío, Ana

    2016-01-01

    Sin duda, investigar a dos escritores como Francisco Umbral y Mario Vargas Llosa ambos situados en el Olimpo de los grandes escritores del siglo XX, no ha sido tarea fácil, pero sí verdaderamente fascinante. Poseedores de talento, creatividad y de genio literario son portadores de una marca propia e indeleble en el periodismo, en el ensayo crítico y en la narrativa. Dos columnas equidistantes y equivalentes con voz propia que se han coronado por igual gracias a sus productivas vidas. En suma,...

  6. Lo spirito dorato. San Francisco e il Parco Crissy Field degli Hargreaves Associates

    Directory of Open Access Journals (Sweden)

    Enrica Dall’Ara

    2015-11-01

    Full Text Available Nel saggio si presenta il progetto di riqualificazione degli Hargreaves Associates per il waterfront della costa nord di San Francisco, un’ area dimessa dall’aviazione ed appartenente al Golden Gate National Recreational Area denominata Crissy Field. Il progetto si presenta sia come risposta chiara a specifiche necessità ambientali che come espressione di volontà estetiche ben misurate e si basa su un principio di conservazione del genius loci della metropoli, confrontandosi con lo status di landmark nazionale attribuito all’area nel 1962. 

  7. Natural Magnetic Fields Preceding the Loma Prieta Earthquake that Damaged San Francisco in October 1989

    Science.gov (United States)

    Campbell, W. H.

    2005-05-01

    Available records of the magnetic indices Dst and ap together with USGS standard observatory recordings of the 1-min fields are examined for the time preceding the Loma Prieta earthquake that severely damaged the San Francisco area in October, 1989. The results indicate that a 1990 report claiming the existence of a ULF geomagnetic field precursor signal foretelling a nearby earthquake is very likely false. The observatory study shows that the ULF signal was not local but rather widespread throughout the western United States and therefore expected to be of solar-terrestrial disturbance origin. The two planetary activity indices support this conclusion.

  8. El espacio y la memoria en la obra poética de Francisco Brines

    OpenAIRE

    Gómez Toré, José Luis

    2002-01-01

    La presente tesis doctoral es un estudio de uno de los nombres fundamentales de la poesía española de la segunda mitad del siglo XX, Francisco Brines. La obra poética de Brines es una reflexión constante sobre el tiempo pero simbólicamente puede convertirse en su contrario. El análisis de los distintos espacios (espacios naturales, espacios construidos, el cuerpo como espacio, el espacio textual que aparecen en su obra permite descubrir algunas de las claves simbólicas de su mundo poético, q...

  9. Classes and problems of natural philosophy of P. Francisco Mendoça SJ

    Directory of Open Access Journals (Sweden)

    Carlota Miranda Urbano

    2016-08-01

    Full Text Available The author presents De floribus Philosophiae written by the famous Jesuit Francisco Mendoça (†1626, professor of Philosophy and rector of the College of Arts in Coimbra in the first years of the XVIIth century. The work was published in a thick volume edited by the said College after the author’s death with the title Viridarium Sacrae et profanae eruditionis a real monument of encyclopaedic knowledge. 47 problemas are presented in De floribus Philosophiae, pertaining to Geography, Anatomy, Physics, Psychology, Astronomy and Anthropology. The text can thus be read as a contribution to the history of science.

  10. Remote sensing analysis of water quality in the San Francisco Bay-delta

    Science.gov (United States)

    Khorram, S.

    1979-01-01

    Water quality parameters in the San Francisco Bay-delta area using remotely sensed data combined with in situ data are investigated. The parameters included suspended solids, chlorophyll, turbidity, and electrical conductivity; the ocean color scanner (OCS) data were acquired from a NASA U-2 aircraft, and water quality samples were obtained from boats. It was concluded that areas with high biological activity were clearly discernible on enhanced imagery from OCS data, and it was impossible to locate such areas on aerial photography taken with conventional or infrared sensitive color films.

  11. Is San Francisco's "The Shaking Man" an urban depiction of parkinsonism?

    Science.gov (United States)

    Germiniani, Francisco Manoel Branco; Staziaki, Pedro Vinícius; Furtado, Vanessa Fiorini; Teive, Helio A G

    2013-04-01

    Art and Medicine often mingle in the most unexpected ways. One can often find in pictorial art the representation of many medical conditions. The same can happen with sculptures; however, the finding of an urban sculpture in a public space with features of parkinsonism is unique. We reported how "The Shaking Man", an urban sculpture located in the Yerba Buena Gardens in San Francisco, USA, is a contemporary representation of parkinsonism and compared it with other art works in different media that also present such thing to laymen.

  12. Stable lead isotopic analyses of historic and contemporary lead contamination of San Francisco Bay estuary

    Science.gov (United States)

    Ritson, P.I.; Bouse, R.M.; Flegal, A.R.; Luoma, S.N.

    1999-01-01

    Variations in stable lead isotopic composition (240Pb, 206Pb, 207Pb, 208Pb) in three sediment cores from the San Francisco Bay estuary document temporal changes in sources of lead during the past two centuries. Sediment, with lead from natural geologic sources, and relatively homogeneous lead isotopic compositions are overlain by sediments whose isotopic compositions indicate change in the sources of lead associated with anthropogenic modification of the estuary. The first perturbations of lead isotopic composition in the cores occur in the late 1800s concordant with the beginning of industrialization around the estuary. Large isotopic shifts, toward lower 206Pb/207Pb, occur after the turn of the century in both Richardson and San Pablo Bays. A similar relationship among lead isotopic compositions and lead concentrations in both Bays suggest contamination from the same source (a lead smelter). The uppermost sediments (post 1980) of all cores also have a relatively homogenous lead isotopic composition distinct from pre-anthropogenic and recent aerosol signatures. Lead isotopic compositions of leachates from fourteen surface sediments and five marsh samples from the estuary were also analyzed. These analyses suggest that the lead isotopic signature identified in the upper horizons of the cores is spatially homogeneous among recently deposited sediments throughout the estuary. Current aerosol lead isotopic compositions [Smith, D.R., Niemeyer, S., Flegal, A.R., 1992. Lead sources to California sea otters: industrial inputs circumvent natural lead biodepletion mechanisms. Environmental Research 57, 163-175] are distinct from the isotopic compositions of the surface sediments, suggesting that the major source of lead is cycling of historically contaminated sediments back through the water column. Both the upper core sediments and surface sediments apparently derive their lead predominantly from sources internal to the estuary. These results support the idea that

  13. Francisco Gil y Lemos, gobernador de las islas Malvinas (1774-1777

    Directory of Open Access Journals (Sweden)

    Iago Gil Aguado

    2014-03-01

    Full Text Available La colonia de Puerto Soledad en las islas Malvinas, guarnecida de 1767 a 1811 por tropas españolas, constituía una de las posesiones más remotas y aisladas de la Monarquía Española. Aunque la existencia de la misma ha sido escasamente estudiada, era considerada en la época de gran importancia estratégica para el control de la América meridional y el paso por el Cabo de Hornos. En este artículo se reconstruye la vida y características de la colonia, estudiando el mandato del futuro virrey y ministro de Marina Francisco Gil y Lemos a la cabeza de la misma. Se trata de años clave para su configuración definitiva, en los que, debido a las condiciones climatológicas extremas, se abandonó definitivamente el proyecto de establecer una colonia de población en las islas, reformándose su estructura de gobierno para convertir Puerto Soledad en un presidio destinado exclusivamente a garantizar la soberanía de España sobre el archipiélago. Son asimismo años clave para determinar la soberanía de las islas, ya que hasta 1776 existió una delicada cohabitación con la factoría británica de Port Egmont, que sería definitivamente abandonada por los ingleses durante el gobierno de Francisco Gil y Lemos.The colony of Puerto Soledad in the Falkland Islands, garrisoned by Spain from 1767 to 1811, was one of the most remote and isolated possessions of the Spanish Empire. Despite the fact that it was considered of the utmost strategic importance at the time, it has scarcely received any serious attention. This article studies the characteristics of and daily life in the colony, analysing the governorship of the future Viceroy and First Lord of the Spanish Admiralty Francisco Gil y Lemos. During his years as Governor, plans for the establishment of a permanent civilian settlement in the Falklands were finally dropped due to the extreme climatic conditions on the islands, and Puerto Soledad assumed its definitive role as a purely military outpost

  14. Modeling Sulfides, pH and Hydrogen Sulfide Gas in the Sewers of San Francisco

    DEFF Research Database (Denmark)

    Vollertsen, Jes; Revilla, Nohemy; Hvitved-Jacobsen, Thorkild

    2015-01-01

    An extensive measuring campaign targeted on sewer odor problems was undertaken in San Francisco. It was assessed whether a conceptual sewer process model could reproduce the measured concentrations of total sulfide in the wastewater and H2S gas in the sewer atmosphere, and to which degree...... (WATS) sewer process concept, which never had been calibrated to such an extensive dataset. The study showed that the model was capable of reproducing the general levels of wastewater sulfide, wastewater pH, and sewer H2S gas. It could also reproduce the general variability of these parameters, albeit...

  15. SF-ROCKS: Reaching Out to Communities and Kids With Science in San Francisco

    Science.gov (United States)

    White, L. D.; Grove, K.; La Force, M. J.; Pestrong, R.; Dempsey, D. P.; Garcia, O.; Garfield, N.

    2002-12-01

    The SF-ROCKS program at San Francisco State University (SFSU), funded by a grant from the NSF-OEDG program, aims to increase the number of traditionally underrepresented students who enter college as geoscience majors through a multi-faceted collaborative watershed research project that provides teacher training, student education, and several tiers of mentoring relationships. In partnership with the San Francisco Unified School District and the City College of San Francisco (CCSF), SFSU Geosciences Department faculty guide urban high school students and their teachers in field-based research projects in the Islais, Yosemite, and Mission creek watersheds in southeastern San Francisco. SFSU and CCSF students assist teachers in the classroom and help to mentor their students. The collaborative program has a research base at SFSU and during the next several years will involve five high schools in communities that have highly diverse populations and ongoing environmental problems. Our goal with each high school is to focus earth and environmental science teachers on the geologic setting around their school, and to provide teachers and their students with relevant resources via teacher workshops, frequent interactions with college faculty and students, and an interactive web site and GIS database. During the summer of 2002, project scientists worked with 9th grade Integrated/Environmental Science teachers at Phillip and Sala Burton High School on a multi-layered, hands-on mapping and sampling partnership designed to identify and monitor environmental hazards and watershed characteristics in the Yosemite Creek watershed. The watershed - within which Burton High School is located - provides an interdisciplinary focus for collecting and analyzing rocks, soils, water chemistry and rainfall characteristics. SFSU faculty incorporated concepts and data from the project into ten watershed-theme lesson plans that are now part of the year-long Integrated Science curriculum at the

  16. O Comitê da Bacia Hidrográfica do Rio São Francisco: a gestão das águas e a transposição do Rio São Francisco

    OpenAIRE

    Pires, Ana Paula Novais [UNESP

    2016-01-01

    O Comitê da Bacia Hidrográfica do Rio São Francisco (CBHSF), criado por Decreto Presidencial em 2001, objetiva concretizar a gestão descentralizada e participativa das águas do Rio São Francisco. O Rio escoa superficialmente por 2.700 km entre a nascente, na Serra da Canastra (MG), à foz, em meio aos estados Sergipe (SE) e Alagoas (AL). O Rio compreende ainda os estados da Bahia (BA), Pernambuco (PE), parte de Goiás (GO) e do Distrito Federal (DF). Assim sendo, este estudo objetiva analisar a...

  17. On the Origin of De Novo Genes in Arabidopsis thaliana Populations.

    Science.gov (United States)

    Li, Zi-Wen; Chen, Xi; Wu, Qiong; Hagmann, Jörg; Han, Ting-Shen; Zou, Yu-Pan; Ge, Song; Guo, Ya-Long

    2016-08-03

    De novo genes, which originate from ancestral nongenic sequences, are one of the most important sources of protein-coding genes. This origination process is crucial for the adaptation of organisms. However, how de novo genes arise and become fixed in a population or species remains largely unknown. Here, we identified 782 de novo genes from the model plant Arabidopsis thaliana and divided them into three types based on the availability of translational evidence, transcriptional evidence, and neither transcriptional nor translational evidence for their origin. Importantly, by integrating multiple types of omics data, including data from genomes, epigenomes, transcriptomes, and translatomes, we found that epigenetic modifications (DNA methylation and histone modification) play an important role in the origination process of de novo genes. Intriguingly, using the transcriptomes and methylomes from the same population of 84 accessions, we found that de novo genes that are transcribed in approximately half of the total accessions within the population are highly methylated, with lower levels of transcription than those transcribed at other frequencies within the population. We hypothesized that, during the origin of de novo gene alleles, those neutralized to low expression states via DNA methylation have relatively high probabilities of spreading and becoming fixed in a population. Our results highlight the process underlying the origin of de novo genes at the population level, as well as the importance of DNA methylation in this process. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  18. Glucagon infusion increases rate of purine synthesis de novo in rat liver

    International Nuclear Information System (INIS)

    Itakura, Mitsuo; Maeda, Noriaki; Tsuchiya, Masami; Yamashita, Kamejiro

    1987-01-01

    Based on the parallel increases of glucagon, the second peak of hepatic cAMP, and the rate of purine synthesis de novo in the prereplicative period in regenerating rate liver after a 70% hepatectomy, it was hypothesized that glucagon is responsible for the increased rate of purine synthesis de novo. To test this hypothesis, the effect of glucagon or dibutyryl cAMP infusion on the rate of purine synthesis de novo in rat liver was studied. Glucagon infusion but not insulin or glucose infusion increased the rate of purine synthesis de novo, which was assayed by [ 14 C]glycine or [ 14 C]formate incorporation, by 2.7- to 4.3-fold. Glucagon infusion increased cAMP concentrations by 4.9-fold and 5-phosphoribosyl-1-pyrophosphate concentrations by 1.5-fold in liver but did not change the specific activity of amidophosphoribosyltransferase or purine ribonucleotide concentrations. Dibutyryl cAMP infusion also increased the rate of purine synthesis de novo by 2.2- to 4.0-fold. Because glucagon infusion increased the rate of purine synthesis de novo in the presence of unchanged purine ribonucleotide concentrations, it is concluded that glucagon after infusion or in animals after a 70% hepatectomy is playing an anabolic role to increase the rate of purine synthesis de novo by increasing cAMP and 5-phosphoribosyl-1-pyrophosphate concentrations

  19. Contribución a la iconografía del venerable Juan de Palafox. Una nueva obra firmada de Francisco Bayeu

    Directory of Open Access Journals (Sweden)

    Rincón García, Wifredo

    2010-12-01

    Full Text Available A new painting about the venerable Juan de Palafox, signed by Francisco Bayeu, is here presented. It was probably an oil sketch for an altarpiece.

    Se da a conocer una nueva pintura sobre el venerable Juan de Palafox, firmada, de Francisco Bayeu, posible boceto para un cuadro destinado a un retablo.

  20. Handbook of Techniques and Guides for the Study of the San Francisco Bay-Delta-Estuary Complex, Part 2. Key to the Phytoplankton Phyla and Genera.

    Science.gov (United States)

    Helrich, Jane

    Project MER (Marine Ecology Research) is aimed at improving environmental education in the San Francisco Bay Area schools. This document is the second of a series of guides designed to help students and teachers gather data concerning the San Francisco Bay-Delta-Estuary Complex and to organize these data to make a contribution to the literature of…

  1. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

    DEFF Research Database (Denmark)

    Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent

    2017-01-01

    or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high......-coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set...

  2. Alternative normalization methods demonstrate widespread cortical hypometabolism in untreated de novo Parkinson's disease

    DEFF Research Database (Denmark)

    Berti, Valentina; Polito, C; Borghammer, Per

    2012-01-01

    metabolic alterations in de novo PD. METHODS: [18F]FDG PET scans of 26 untreated de novo PD patients (Hoehn & Yahr stage I-II) and 21 age-matched controls were compared using voxel-based analysis. Normalization was performed using gray matter (GM), white matter (WM) reference regions and Yakushev......, in the WM and Yakushev normalized analyses, stage II patients displayed more prominent cortical hypometabolism than did stage I patients. CONCLUSION: The use of alternative normalization procedures, other than GM, suggests that much more extensive cortical hypometabolism is present in untreated de novo PD...

  3. Immunotherapy for De Novo renal transplantation: what's in the pipeline?

    Science.gov (United States)

    Tedesco Silva, Helio; Pinheiro Machado, Paula; Rosso Felipe, Claudia; Medina Pestana, Jose Osmar

    2006-01-01

    Immunosuppressive drugs have been traditionally developed to prevent acute rejection and to improve short-term kidney transplant outcomes. There is still a medical need to improve outcomes among subgroups of patients at higher risk for graft loss and to reduce cardiovascular, infectious and malignancy-associated morbidity and mortality, and improve long-term adherence. Several new immunosuppressive agents and formulations are undergoing clinical investigation and are discussed in this review.A modified release tacrolimus formulation (MR4) for once-daily administration is undergoing phase III trials. It has been developed to be administered de novo or for maintenance using the same therapeutic target tacrolimus trough concentrations as for the original formulation. Belatacept (LEA29Y), a second generation cytotoxic-T-lymphocyte-associated antigen immunoglobulin (CTLA4-Ig), blocks the interaction between CD80/86 and CD28 costimulatory pathways. In phase II trials, belatacept was as effective as ciclosporin (cyclosporine) when administered in combination with basiliximab, mycophenolate mofetil (MMF) and corticosteroids. Currently, belatacept is undergoing phase III trials including one study in recipients of organs from expanded criteria donors. Inhibitors of the Janus protein tyrosine kinase (JAK)-3 show some selectivity for cells of the lymphoid lineage and have been shown to be effective in late preclinical transplant models. The most frequent adverse effects have been related to nonspecific binding to JAK2 kinases. CP-690550, a JAK3 inhibitor is currently in phase II clinical trials.FK778, is a synthetic malononitrilamide that targets the critical enzyme of the de novo pyrimidine synthesis, dihydroorotic acid dehydrogenase, and receptor-associated tyrosine kinases has completed phase II trials. FK778 also shows antiviral activities that have been tested in patients with polyomavirus nephropathy. Fingolimod (FTY720), a synthetic sphingosine phosphate receptor

  4. De novo assembly and phasing of a Korean human genome.

    Science.gov (United States)

    Seo, Jeong-Sun; Rhie, Arang; Kim, Junsoo; Lee, Sangjin; Sohn, Min-Hwan; Kim, Chang-Uk; Hastie, Alex; Cao, Han; Yun, Ji-Young; Kim, Jihye; Kuk, Junho; Park, Gun Hwa; Kim, Juhyeok; Ryu, Hanna; Kim, Jongbum; Roh, Mira; Baek, Jeonghun; Hunkapiller, Michael W; Korlach, Jonas; Shin, Jong-Yeon; Kim, Changhoon

    2016-10-13

    Advances in genome assembly and phasing provide an opportunity to investigate the diploid architecture of the human genome and reveal the full range of structural variation across population groups. Here we report the de novo assembly and haplotype phasing of the Korean individual AK1 (ref. 1) using single-molecule real-time sequencing, next-generation mapping, microfluidics-based linked reads, and bacterial artificial chromosome (BAC) sequencing approaches. Single-molecule sequencing coupled with next-generation mapping generated a highly contiguous assembly, with a contig N50 size of 17.9 Mb and a scaffold N50 size of 44.8 Mb, resolving 8 chromosomal arms into single scaffolds. The de novo assembly, along with local assemblies and spanning long reads, closes 105 and extends into 72 out of 190 euchromatic gaps in the reference genome, adding 1.03 Mb of previously intractable sequence. High concordance between the assembly and paired-end sequences from 62,758 BAC clones provides strong support for the robustness of the assembly. We identify 18,210 structural variants by direct comparison of the assembly with the human reference, identifying thousands of breakpoints that, to our knowledge, have not been reported before. Many of the insertions are reflected in the transcriptome and are shared across the Asian population. We performed haplotype phasing of the assembly with short reads, long reads and linked reads from whole-genome sequencing and with short reads from 31,719 BAC clones, thereby achieving phased blocks with an N50 size of 11.6 Mb. Haplotigs assembled from single-molecule real-time reads assigned to haplotypes on phased blocks covered 89% of genes. The haplotigs accurately characterized the hypervariable major histocompatability complex region as well as demonstrating allele configuration in clinically relevant genes such as CYP2D6. This work presents the most contiguous diploid human genome assembly so far, with extensive investigation of

  5. World Antibody-Drug Conjugate Summit, October 15-16, 2013, San Francisco, CA.

    Science.gov (United States)

    Klinguer-Hamour, Christine; Strop, Pavel; Shah, Dhaval K; Ducry, Laurent; Xu, April; Beck, Alain

    2014-01-01

    The World Antibody-Drug Conjugate (WADC) Summits organized by Hanson Wade are currently the largest meetings fully dedicated to ADCs. The first global ADC Summit was organized in Boston in October 2010. Since 2011, two WADC are held every year in Frankfurt and San Francisco, respectively. The 2013 WADC San Francisco event was structured around plenary sessions with keynote speakers from AbbVie, Agensys, ImmunoGen, Immunomedics, Genentech, Pfizer and Seattle Genetics. Parallel tracks were also organized addressing ADC discovery, development and optimization of chemistry, manufacturing and control (CMC) issues. Discovery and process scientists, regulatory experts (US Food and Drug Administration), academics and clinicians were present, including representatives from biotechnology firms (Concortis, CytomX Therapeutics, Glykos, Evonik, Igenica, Innate Pharma, Mersana Therapeutics, Polytherics, Quanta Biodesign, Redwood Bioscience, Sutro Biopharma, SynAffix), pharmaceutical companies (Amgen, Genmab, Johnson and Johnson, MedImmune, Novartis, Progenics, Takeda) and contract research or manufacturing organizations (Baxter, Bayer, BSP Pharmaceuticals, Fujifilm/Diosynth, Lonza, Pierre Fabre Contract Manufacturing, Piramal, SAFC, SafeBridge).

  6. As ceramistas indígenas do São Francisco

    Directory of Open Access Journals (Sweden)

    Luiz Sávio de Almeida

    2003-12-01

    Full Text Available OS KARIRI-XOCÓ localizam-se no Baixo São Francisco, Estado de Alagoas no nordeste do Brasil. A cerâmica utilitária é uma das atividades básicas enquanto geração de renda, sendo produzida e comercializada por mulheres. O texto é uma nota prévia sobre a história desta cerâmica, abordando o dia a dia, as expectativas e a condição de vida das louceiras.THE KARIRI-XOCÓ inhabit the lower São Francisco region in the state of Alagoas, in northeastern Brazil. Utilitarian pottery is one of their basic income-generating activities and the ceramic artifacts are produced and marketed by women. This essay is a foreword on the history of this kind of ceramics and depicts the day-to-day of the potters, their expectations and their way of living.

  7. Francisco Ayala:cenas e projeções da Guerra Civil

    Directory of Open Access Journals (Sweden)

    Silvia Inés Cárcamo Arcuri

    2009-06-01

    Full Text Available Cenas ou momentos pontuais da ficção de Francisco Ayala relacionados com a Guerra Civil Espanhola e com a reflexão sobre o poder apresentam-se como particularmente instigantes se aproximados, pela leitura relacional, a outros textos da literatura espanhola contemporânea. Sem ignorar os contextos sociais da enunciação dos discursos, cremos válidas as tentativas de leitura de Francisco Ayala que não se restrinjam aos enquadramentos tradicionais, ainda que não questionemos como princípio de organização historiográfica as denominações consagradas de “Geração de 31”, ou “Grupo dos exilados, dos transterrados ou dos refugiados da guerra civil”. Vinculamos momentos textuais de Ayala, Unamuno e Cercas referidos às reatualizações das dimensões política e ética da guerra e do poder.

  8. A cold phase of the East Pacific triggers new phytoplankton blooms in San Francisco Bay

    Science.gov (United States)

    Cloern, J.E.; Jassby, A.D.; Thompson, J.K.; Hieb, K.A.

    2007-01-01

    Ecological observations sustained over decades often reveal abrupt changes in biological communities that signal altered ecosystem states. We report a large shift in the biological communities of San Francisco Bay, first detected as increasing phytoplankton biomass and occurrences of new seasonal blooms that began in 1999. This phytoplankton increase is paradoxical because it occurred in an era of decreasing wastewater nutrient inputs and reduced nitrogen and phosphorus concentrations, contrary to the guiding paradigm that algal biomass in estuaries increases in proportion to nutrient inputs from their watersheds. Coincidental changes included sharp declines in the abundance of bivalve mollusks, the key phytoplankton consumers in this estuary, and record high abundances of several bivalve predators: Bay shrimp, English sole, and Dungeness crab. The phytoplankton increase is consistent with a trophic cascade resulting from heightened predation on bivalves and suppression of their filtration control on phytoplankton growth. These community changes in San Francisco Bay across three trophic levels followed a state change in the California Current System characterized by increased upwelling intensity, amplified primary production, and strengthened southerly flows. These diagnostic features of the East Pacific "cold phase" lead to strong recruitment and immigration of juvenile flatfish and crustaceans into estuaries where they feed and develop. This study, built from three decades of observation, reveals a previously unrecognized mechanism of ocean-estuary connectivity. Interdecadal oceanic regime changes can propagate into estuaries, altering their community structure and efficiency of transforming land-derived nutrients into algal biomass. ?? 2007 by The National Academy of Sciences of the USA.

  9. La poética iluminada de la locura: Francisco Matos Paoli contra el imperio

    Directory of Open Access Journals (Sweden)

    María Giulianna Zambrano Murillo

    2017-01-01

    Full Text Available Este artículo propone una exégesis del poema carcelario “Canto de la locura” (1962 del puertorriqueño Francisco Matos Paoli (1915-2000 como una defensa de la locura como posibilidad epistémica y poética liberadora frente a la biopolítica carcelaria y colonial. En los años cincuenta, el nacionalismo puertorriqueño, además de ser proscrito mediante la Ley 53, conocida como la Mordaza, fue estigmatizado como una amenaza delirante a la estabilidad del Gobierno en la isla. Con una voz poética hiperlúcida que desborda los límites del lenguaje, Matos Paoli insiste en la pregunta por la libertad de la isla mientras denuncia la violencia colonial estadounidense. This article proposes a reading of the poem “Canto de la locura” (1962, written by Puerto Rican Francisco Matos Paoli (1915-2000, as defending madness as an epistemic possibility as well as an emancipatory poetics in the face of penitentiary and colonial biopolitics. In the 1950s, Puerto Rican nationalism, in addition to being prohibited by Law 53, known as la Mordaza (Gag Law, was stigmatized as a delirious threat to the stability of the island’s government. With a hyperlucid poetic voice that exceeds the limits of language, Matos Paoli insists on the question of freedom for Puerto Rico while denouncing the colonial violence of the United States.

  10. INDICADORES AMBIENTAIS PARA O ESTUDO DA EROSÃO MARGINAL NO RIO SÃO FRANCISCO.

    Directory of Open Access Journals (Sweden)

    Maria Francineide Rosendo Guimarães

    2010-08-01

    Full Text Available As ações propostas na Agenda 21, com ênfase na construção de indicadores ambientais vem possibilitar um aperfeiçoamento nos modelos de gerenciamento dos recursos naturais, através da avaliação das medidas adotadas e monitoramento das ações estratégicas a serem empregadas com vistas ao desenvolvimento sustentável. Esse trabalho teve como objetivo a construção de indicadores ambientais relacionados ao processo erosivo na margem direita do Baixo São Francisco Sergipano. Foi adotada a metodologia da OCDE (Organização para a Cooperação e Desenvolvimento Econômico, o modelo de Indicadores de Pressão-Estado-Impacto-Efeito-Resposta (PEI/ER, para a construção de uma matriz de indicadores. A quantificação do processo erosivo através de trinta indicadores ambientais vem subsidiar políticas e ações voltadas para a mitigação dos efeitos nocivos da degradação ambiental naquela área. Palavras-chave: Indicador ambiental, Erosão marginal, Rio São Francisco.

  11. Reflexiones sobre el viaje de Francisco de Miranda al Imperio Otomano

    Directory of Open Access Journals (Sweden)

    Mehmet Necati Kutlu

    2007-01-01

    Full Text Available Francisco de Miranda, en sus viajes por Europa, permanció casi tres meses en el Imperio Otomano (en Esmirna y Estambul. En sus escritos, el político venezolano se refirió especialmente a la vida social y cultural, a la economía y al ejército y a la defensa de Turquía. Por ello, el conocimiento de primera mano de estos aspectos parece la motivación fundamental de su estancia, sin que sea posible señalar ninguna gestión en busca de apoyo a la causa de la independencia americana.Francisco de Miranda, in his travels across Europe, visited for almost three months the Ottoman Empire (Izmir and Istambul. In his writings, the Venezuelan politician dealt especially with social and cultural life, the economy and the army and defence of the country. This is why the first-hand knowledge of these aspects seems to be the main reason of his stay; instead, it is not possible to find any step in the search of support for the American independence.

  12. Sediment transport in the San Francisco Bay Coastal System: An overview

    Science.gov (United States)

    Barnard, Patrick L.; Schoellhamer, David H.; Jaffe, Bruce E.; Lester J. McKee,

    2013-01-01

    The papers in this special issue feature state-of-the-art approaches to understanding the physical processes related to sediment transport and geomorphology of complex coastal-estuarine systems. Here we focus on the San Francisco Bay Coastal System, extending from the lower San Joaquin-Sacramento Delta, through the Bay, and along the adjacent outer Pacific Coast. San Francisco Bay is an urbanized estuary that is impacted by numerous anthropogenic activities common to many large estuaries, including a mining legacy, channel dredging, aggregate mining, reservoirs, freshwater diversion, watershed modifications, urban run-off, ship traffic, exotic species introductions, land reclamation, and wetland restoration. The Golden Gate strait is the sole inlet connecting the Bay to the Pacific Ocean, and serves as the conduit for a tidal flow of ~ 8 x 109 m3/day, in addition to the transport of mud, sand, biogenic material, nutrients, and pollutants. Despite this physical, biological and chemical connection, resource management and prior research have often treated the Delta, Bay and adjacent ocean as separate entities, compartmentalized by artificial geographic or political boundaries. The body of work herein presents a comprehensive analysis of system-wide behavior, extending a rich heritage of sediment transport research that dates back to the groundbreaking hydraulic mining-impact research of G.K. Gilbert in the early 20th century.

  13. A self-modifying cellular automaton model of historical urbanization in the San Francisco Bay area

    Science.gov (United States)

    Clarke, K.C.; Hoppen, S.; Gaydos, L.

    1997-01-01

    In this paper we describe a cellular automaton (CA) simulation model developed to predict urban growth as part of a project for estimating the regional and broader impact of urbanization on the San Francisco Bay area's climate. The rules of the model are more complex than those of a typical CA and involve the use of multiple data sources, including topography, road networks, and existing settlement distributions, and their modification over time. In addition, the control parameters of the model are allowed to self-modify: that is, the CA adapts itself to the circumstances it generates, in particular, during periods of rapid growth or stagnation. In addition, the model was written to allow the accumulation of probabilistic estimates based on Monte Carlo methods. Calibration of the model has been accomplished by the use of historical maps to compare model predictions of urbanization, based solely upon the distribution in year 1900, with observed data for years 1940, 1954, 1962, 1974, and 1990. The complexity of this model has made calibration a particularly demanding step. Lessons learned about the methods, measures, and strategies developed to calibrate the model may be of use in other environmental modeling contexts. With the calibration complete, the model is being used to generate a set of future scenarios for the San Francisco Bay area along with their probabilities based on the Monte Carlo version of the model. Animated dynamic mapping of the simulations will be used to allow visualization of the impact of future urban growth.

  14. Input, flux, and persistence of six select pesticides in San Francisco Bay

    Science.gov (United States)

    Kuivila, K.M.; Jennings, B.E.

    2007-01-01

    Temporal patterns of pesticide inputs to San Francisco Bay were identified and correlated with timing of application and transport mechanism. Fluxes were calculated from measured concentrations and estimated flow. Persistence of the pesticides under typical riverine or estuarine conditions were estimated from laboratory experiments. Simazine was detected most frequently and had the highest flux into the Bay, which could be explained by its continuous use and long half-life. In comparison, diazinon was detected at lower concentrations and had a lower flux which corresponded to its lower use and shorter half-life. The order-of-magnitude lower fluxes of carbofuran and methidathion corresponded to their lower use and expected hydrolysis. Molinate was detected at the highest concentration but its flux was lower than expected, considering its very high use and persistence in the laboratory experiments. Additional loss of molinate is likely to occur from volatilization and photodegradation on the rice fields. Although thiobencarb had the second highest use, it had the lowest flux of the six pesticides, which can be attributed to its loss via hydrolysis, photodegradation, volatilization, and sorption to sediments. Fluxes into San Francisco Bay were equal to or greater than those reported for other estuaries, except for the Gulf of Mexico. ?? 2007 Taylor & Francis.

  15. Evaluation of chlamydia and gonorrhea screening criteria: San Francisco sexually transmitted disease clinic: 1997 to 1998.

    Science.gov (United States)

    Ciemins, E L; Kent, C K; Flood, J; Klausner, J D

    2000-03-01

    The advent of more sensitive diagnostic testing technologies and competition in public healthcare spending have resulted in a reevaluation of sexually transmitted disease (STD) screening practices in an attempt to target populations at greatest risk. Screening among populations with a < 2% prevalence of chlamydia and a < 1% prevalence of gonorrhea may not be cost-effective. To identify subpopulations with a low prevalence of chlamydia or gonorrhea. The prevalence of genital chlamydia and gonorrhea among asymptomatic STD patients screened from 1997 to 1998 at San Francisco City Clinic was stratified by demographic and behavioral risk factors. The prevalence of chlamydia and gonorrhea was 3.4% and 1.1% among asymptomatic women and 4.0% and 1.0% among asymptomatic men, respectively. Two low-prevalence subpopulations identified among asymptomatic patients were women older than 29 years (chlamydia, 1.2%) and men who have sex with women (gonorrhea, 0.8%). These data identified low-prevalence subpopulations among asymptomatic STD patients. As a result, the STD screening criteria at San Francisco City Clinic were changed accordingly.

  16. Spatial and temporal variations in silver contamination and toxicity in San Francisco Bay

    Science.gov (United States)

    Flegal, A.R.; Brown, C.L.; Squire, S.; Ross, J.R.M.; Scelfo, G.M.; Hibdon, S.

    2007-01-01

    Although San Francisco Bay has a "Golden Gate", it may be argued that it is the "Silver Estuary". For at one time the Bay was reported to have the highest levels of silver in its sediments and biota, along with the only accurately measured values of silver in solution, of any estuarine system. Since then others have argued that silver contamination is higher elsewhere (e.g., New York Bight, Florida Bay, Galveston Bay) in a peculiar form of pollution machismo, while silver contamination has measurably declined in sediments, biota, and surface waters of the Bay over the past two to three decades. Documentation of those systemic temporal declines has been possible because of long-term, ongoing monitoring programs, using rigorous trace metal clean sampling and analytical techniques, of the United States Geological Survey and San Francisco Bay Regional Monitoring Program that are summarized in this report. However, recent toxicity studies with macro-invertebrates in the Bay have indicated that silver may still be adversely affecting the health of the estuarine system, and other studies have indicated that silver concentrations in the Bay may be increasing due to new industrial inputs and/or the diagenetic remobilization of silver from historically contaminated sediments being re-exposed to overlying surface waters and benthos. Consequently, the Bay may not be ready to relinquish its title as the "Silver Estuary". ?? 2007 Elsevier Inc. All rights reserved.

  17. Prevalence of seroadaptive behaviours of men who have sex with men, San Francisco, 2004.

    Science.gov (United States)

    Snowden, J M; Raymond, H F; McFarland, W

    2009-10-01

    To define and measure the prevalence of HIV seroadaptive behaviours among men who have sex with men (MSM). A community-based, cross-sectional sample of 1211 HIV negative and 251 HIV positive MSM was recruited in San Francisco in 2004 by time-location sampling. Seroadaptive behaviours were defined by enumerating and characterising all episodes of anal intercourse by partner type, partner HIV serostatus, sexual position and condom use for up to five partners in the preceding 6 months. Among HIV negative MSM, 37.6% engaged in some form of apparent seroadaptive behaviour, predominantly pure serosorting (24.7%), followed by seropositioning (5.9%), condom serosorting (3.9%) and negotiated safety (3.1%). Among HIV positive men, 43.4% engaged in some form of seroadaptation, including pure serosorting (19.5%), seropositioning (14.3%) and condom serosorting (9.6%). Consistent condom use was reported by 37.1% of HIV negative and 20.7% of HIV positive MSM. In aggregate, seroadaptive behaviours appear to be the most common HIV prevention strategy adopted by MSM in San Francisco as of 2004. Surveillance and epidemiological studies need to precisely measure seroadaptive behaviours in order to gauge and track the true level of HIV risk in populations. Rigorous prevention research is needed to assess the efficacy of seroadaptive behaviours on individuals' risk and on the epidemic.

  18. La estatua de Francisco Pizarro en Lima. Historia e identidad nacional

    Directory of Open Access Journals (Sweden)

    Varón Gabai, Rafael

    2006-04-01

    Full Text Available Historical account of the statue of Francisco Pizarro in Lima, one of the few that recalls the memory of a conquistador in Latin America. Mention is made of the foundry and exhibition of the different statues of Pizarro as conceived by artist Charles Cary Rumsey, and popular ideas about it. Finally, analysis is offered of the present day perception Peruvians have of the Conquest and what Pizarro’s statue symbolizes to them.

    Recuento histórico de la estatua dedicada a Francisco Pizarro en Lima, una de las pocas que conmemoran a un conquistador español en Hispanoamérica. Se relata la fabricación y exhibición de las diversas estatuas gemelas que realizó el artista Charles Cary Rumsey y las creencias populares al respecto. Asimismo, se analiza la vigencia que mantiene entre la población peruana actual el impacto de la conquista y el símbolo que representa la estatua de Pizarro.

  19. A Pilot Study of Retail ‘Vape Shops’ in the San Francisco Bay Area

    Science.gov (United States)

    Burbank, Andrea D; Thrul, Johannes; Ling, Pamela M

    2016-01-01

    INTRODUCTION The use of electronic cigarettes or vape devices is increasing, and products are evolving rapidly. This study assessed retail vape shops in the San Francisco Bay Area to describe store characteristics, products offered, advertisements and health claims, as well as employees’ perceptions of their customers’ demographics, and practices to support smoking cessation. METHODS We conducted store audits of shops that exclusively sell vape devices with physical addresses in San Francisco and Alameda counties (n=23, response rate 72%) and interviewed vape shop owners/employees. RESULTS While all stores carried second and third generation vape devices, 83% of stores did not carry first generation devices. Employees estimated the majority of their customers bought devices for smoking cessation or to replace tobacco, and a small minority purchased for first-time recreational use. Employees most frequently recommended dosing nicotine based on usual cigarette consumption, adjusting doses based on “throat hit” or cravings, use of a second or third generation e-cigarette, and encouraged customers to experiment and customize to “whatever works for you” as smoking cessation advice. CONCLUSIONS Vape shops report a significant number of their customers are interested in smoking cessation, and employees are giving smoking cessation advice. A subpopulation of customers includes some nicotine novices. Studies of vape shops should include both observations and interviews with employees in order to detect important informal practices that may differ from posted signs or printed advertising. These practices include cessation counseling, product claims, and custom discount prices or bargaining. PMID:28393129

  20. Suspended sediment and sediment-associated contaminants in San Francisco Bay

    Science.gov (United States)

    Schoellhamer, D.H.; Mumley, T.E.; Leatherbarrow, J.E.

    2007-01-01

    Water-quality managers desire information on the temporal and spatial variability of contaminant concentrations and the magnitudes of watershed and bed-sediment loads in San Francisco Bay. To help provide this information, the Regional Monitoring Program for Trace Substances in the San Francisco Estuary (RMP) takes advantage of the association of many contaminants with sediment particles by continuously measuring suspended-sediment concentration (SSC), which is an accurate, less costly, and more easily measured surrogate for several trace metals and organic contaminants. Continuous time series of SSC are collected at several sites in the Bay. Although semidiurnal and diurnal tidal fluctuations are present, most of the variability of SSC occurs at fortnightly, monthly, and semiannual tidal time scales. A seasonal cycle of sediment inflow, wind-wave resuspension, and winnowing of fine sediment also is observed. SSC and, thus, sediment-associated contaminants tend to be greater in shallower water, at the landward ends of the Bay, and in several localized estuarine turbidity maxima. Although understanding of sediment transport has improved in the first 10 years of the RMP, determining a simple mass budget of sediment or associated contaminants is confounded by uncertainties regarding sediment flux at boundaries, change in bed-sediment storage, and appropriate modeling techniques. Nevertheless, management of sediment-associated contaminants has improved greatly. Better understanding of sediment and sediment-associated contaminants in the Bay is of great interest to evaluate the value of control actions taken and the need for additional controls. ?? 2007 Elsevier Inc. All rights reserved.

  1. A Pilot Study of Retail 'Vape Shops' in the San Francisco Bay Area.

    Science.gov (United States)

    Burbank, Andrea D; Thrul, Johannes; Ling, Pamela M

    2016-01-01

    The use of electronic cigarettes or vape devices is increasing, and products are evolving rapidly. This study assessed retail vape shops in the San Francisco Bay Area to describe store characteristics, products offered, advertisements and health claims, as well as employees' perceptions of their customers' demographics, and practices to support smoking cessation. We conducted store audits of shops that exclusively sell vape devices with physical addresses in San Francisco and Alameda counties (n=23, response rate 72%) and interviewed vape shop owners/employees. While all stores carried second and third generation vape devices, 83% of stores did not carry first generation devices. Employees estimated the majority of their customers bought devices for smoking cessation or to replace tobacco, and a small minority purchased for first-time recreational use. Employees most frequently recommended dosing nicotine based on usual cigarette consumption, adjusting doses based on "throat hit" or cravings, use of a second or third generation e-cigarette, and encouraged customers to experiment and customize to "whatever works for you" as smoking cessation advice. Vape shops report a significant number of their customers are interested in smoking cessation, and employees are giving smoking cessation advice. A subpopulation of customers includes some nicotine novices. Studies of vape shops should include both observations and interviews with employees in order to detect important informal practices that may differ from posted signs or printed advertising. These practices include cessation counseling, product claims, and custom discount prices or bargaining.

  2. Three-dimensional Modeling of Tidal Hydrodynamics in the San Francisco Estuary

    Directory of Open Access Journals (Sweden)

    Edward S. Gross

    2010-01-01

    Full Text Available Simulations of circulation in the San Francisco Estuary were performed with the three-dimensional TRIM3D hydrodynamic model using a generic length scale turbulence closure. The model was calibrated to reproduce observed tidal elevations, tidal currents, and salinity observations in the San Francisco Estuary using data collected during 1996-1998, a period of high and variable freshwater flow. It was then validated for 1994-1995, with emphasis on spring of 1994, a period of intensive data collection in the northern estuary. The model predicts tidal elevations and tidal currents accurately, and realistically predicts salinity at both the seasonal and tidal time scales. The model represents salt intrusion into the estuary accurately, and therefore accurately represents the salt balance. The model’s accuracy is adequate for its intended purposes of predicting salinity, analyzing gravitational circulation, and driving a particle-tracking model. Two applications were used to demonstrate the utility of the model. We estimated the components of the longitudinal salt flux and examined their dependence on flow conditions, and compared predicted salt intrusion with estimates from two empirical models.

  3. Francisco Ferreira Saturnino Braga: negócios e fortuna em Campos dos Goytacazes

    Directory of Open Access Journals (Sweden)

    Walter Luiz Carneiro de Mattos Pereira

    2012-12-01

    Full Text Available O artigo pretende investir no estudo da dinâmica da economia em Campos dos Goytacazes, Rio de Janeiro, nas duas décadas que antecedem a abolição da escravatura no Brasil, a partir dos negócios e da fortuna de Francisco Ferreira Saturnino Braga, proprietário de terras, escravos, usineiro, industrial, concessionário de ferrovias e banqueiro, figura-chave para se perceberem as transformações ocorridas em uma área de produção açucareira voltada para o mercado interno. As singularidades e particularidades obtidas pela observação em escala reduzida podem revelar a possibilidade de perceber uma articulação mais ampla com as estruturas de uma economia de mercado.The article intends to invest in the study of the dynamics of the economy in Campos dos Goytacazes, Rio de Janeiro, in the two decades preceding the abolition of slavery in Brazil, from the business and fortune of Francisco Ferreira Saturnino Braga, owner of land, slaves, mill owner, industrial, railroad dealer and banker, a key figure to understand the changes occurred in an area of the sugar production directs to the domestic market. The singularities and particularities obtained by observation in small scale may reveal the possibility of perceiving a broader articulation with the structures of a market economy.

  4. In-situ measurements of seismic velocities in the San Francisco Bay region...part II

    Science.gov (United States)

    Gibbs, James F.; Fumal, Thomas E.; Borcherdt, Roger D.

    1976-01-01

    Seismic wave velocities (compressional and shear) are important parameters for determining the seismic response characteristics of various geologic units when subjected to strong earthquake ground shaking. Seismic velocities of various units often show a strong correlation with the amounts of damage following large earthquakes and have been used as a basis for certain types of seismic zonation studies. Currently a program is in progress to measure seismic velocities in the San Francisco Bay region at an estimated 150 sites. At each site seismic travel times are measured in drill holes, normally at 2.5-m intervals to a depth of 30 m. Geologic logs are determined from drill hole cuttings, undisturbed samples, and penetrometer samples. The data provide a detailed comparison of geologic and seismic characteristics and provide parameters for estimating strong earthquake ground motions quantitatively at each of the site. A major emphasis of this program is to obtain a detailed comparison of geologic and seismic data on a regional scale for use in seismic zonation. The broad data base available in the San Francisco Bay region suggests using the area as a pilot area for the development of general techniques applicable to other areas.

  5. Deep Borehole Instrumentation Along San Francisco Bay Bridges: 1996 - 2003 and Strong Ground Motion Systhesis Along the San Francisco/Oakland Bay Bridge

    Energy Technology Data Exchange (ETDEWEB)

    Hutchings, L; Foxall, W; Kasameyer, P; larsen, S; Hayek, C; Tyler-Turpin, C; Aquilino, J; Long, L

    2005-04-22

    As a result of collaboration between the Berkeley Seismographic Station, Lawrence Livermore National Laboratory, and Caltrans, instrument packages have been placed in bedrock in six boreholes and two surface sites along the San Francisco/Oakland Bay Bridge. Since 1996 over 200 local earthquakes have been recorded. Prior to this study few seismic recording instruments existed in bed-rock in San Francisco Bay. We utilized the data to perform analysis of ground motion variability, wave passage, site response, and up-and down-hole wave propagation along the Bay Bridge. We also synthesized strong ground motion at nine locations along the Bay Bridge. Key to these studies is LLNL's effort to exploit the information available in weak ground motions (generally from earthquakes < M=4.0) to enhance predictions of seismic hazards. We found that Yerba Island has no apparent site response at the surface relative to a borehole site. The horizontal to vertical spectral ratio method best revealed no site response, while the complex signal spectral ratio method had the lowest variance for spectral ratios and best predicted surface recordings when the borehole recording was used as input. Both methods identified resonances at about the same frequencies. Regional attenuation results in a significant loss of high frequencies in both surface and borehole recordings. Records are band limited at near 3 Hz. Therefore a traditional rock outcrop site response, flat to high frequency in displacement, is not available. We applied a methodology to predict and synthesize strong ground motion along the San Francisco/Oakland Bay Bridge from a M=7.25 earthquake along the Hayward fault, about12 km distant. We synthesized for three-components and broad-band (0.0-25.0 Hz) ground motion accelerations, velocities, and displacements. We examined two different possible rupture scenarios, a ''mean'' and ''one standard deviation'' model. We combined the high

  6. “Metamorfose do espaço habitado” em função de uma nova atividade econômica: a exploração de rochas ornamentais e a valorização do solo no município de Barra de São Francisco - Norte do Espírito Santo

    Directory of Open Access Journals (Sweden)

    Frederico Castro Carvalho

    2013-12-01

    Full Text Available O noroeste do estado do Espírito Santo tem vivenciado um “boom” econômico impulsionado pelas atividades mineradoras relacionadas à exploração de rochas ornamentais, sendo o granito o principal responsável por toda essa dinâmica. As terras da região, em particular as áreas urbanas do município de Barra de São Francisco, têm sido alvo de forte especulação imobiliária devido aos crescentes investimentos do setor de rochas ornamentais. Esse setor tem alterado a dinâmica da cidade francisquense, outrora baseada nas atividades agropecuárias, que tinham no café conilon o pilar de sua economia, assim como a (reconfiguração espacial do município como um todo. A proposta do estudo apresentado consiste em apontar indícios e pistas para se pensar o crescimento das cidades de modo racional no uso e na ocupação dos espaços das áreas urbanas e limítrofes, com o gerenciamento planejado de políticas capazes de promoverem a participação dos atores envolvidos identificando-se os conflitos. Essas políticas devem ser compatíveis com as perspectivas envolvidas, procurando estimular atividades economicamente viáveis e que mantenham um ordenamento na apropriação da paisagem. Abstract “METAMORPHOSIS OF INHABITED SPACE” ACCORDING TO A NEW ECONOMIC ACTIVITY: THE EXPLORATION AND EXPLOITATION OF ROCKS ORMANENTAIS SOIL IN THE MUNICIPALITY OF BARRA DE SÃO FRANCISCO - NORTH OF ESPÍRITO SANTO The northwestern state of Espírito Santo has experienced a ‘boom’ economic driven by mining activities related to the exploitation of ornamental rocks, granite being primarily responsible for this whole dynamic. The lands of the region, in particular the urban areas of the municipality of Barra de São Francisco, has been the subject of strong speculation due to increasing investments in the sector of ornamental rocks. This sector has changed the dynamics of the city francisquense, formerly based on agricultural activities, they had coffee

  7. Status and understanding of groundwater quality in the North San Francisco Bay groundwater basins, 2004

    Science.gov (United States)

    Kulongoski, Justin T.; Belitz, Kenneth; Landon, Matthew K.; Farrar, Christopher

    2010-01-01

    Groundwater quality in the approximately 1,000-square-mile (2,590-square-kilometer) North San Francisco Bay study unit was investigated as part of the Priority Basin Project of the Groundwater Ambient Monitoring and Assessment (GAMA) Program. The study unit is located in northern California in Marin, Napa, and Sonoma Counties. The GAMA Priority Basin Project is being conducted by the California State Water Resources Control Board in collaboration with the U.S. Geological Survey (USGS) and the Lawrence Livermore National Laboratory. The GAMA North San Francisco Bay study was designed to provide a spatially unbiased assessment of untreated groundwater quality in the primary aquifer systems. The assessment is based on water-quality and ancillary data collected by the USGS from 89 wells in 2004 and water-quality data from the California Department of Public Health (CDPH) database. The primary aquifer systems (hereinafter referred to as primary aquifers) were defined by the depth interval of the wells listed in the CDPH database for the North San Francisco Bay study unit. The quality of groundwater in shallower or deeper water-bearing zones may differ from that in the primary aquifers; shallower groundwater may be more vulnerable to surficial contamination. The first component of this study, the status of the current quality of the groundwater resource, was assessed by using data from samples analyzed for volatile organic compounds (VOC), pesticides, and naturally occurring inorganic constituents, such as major ions and trace elements. This status assessment is intended to characterize the quality of groundwater resources within the primary aquifers of the North San Francisco Bay study unit, not the treated drinking water delivered to consumers by water purveyors. Relative-concentrations (sample concentration divided by the health- or aesthetic-based benchmark concentration) were used for evaluating groundwater quality for those constituents that have Federal and (or

  8. O Comitê da Bacia Hidrográfica do Rio São Francisco e a Gestão das Águas: O Conflito Exposto a Partir da Transposição do Rio São Francisco | The São Francisco River Basin Committee and Water Management Conflict Arising from the Transposition of The River

    OpenAIRE

    Ana Paula Novais Pires

    2014-01-01

    Introduction: The São Francisco River Basin Committee (CBHSF) was set up by presidential decree in 2001 with the aim of achieving decentralized and participatory management of its water. The São Francisco River flows overland for 2700 km from its source in the Serra da Canastra (MG) to its mouth between Sergipe (SE) and Alagoas (AL). The river passes through the states of Bahia (BA), Pernambuco (PE), Goiás (GO) and the Federal District (DF). Central to the discussion in this research on the ...

  9. Massively parallel de novo protein design for targeted therapeutics

    KAUST Repository

    Chevalier, Aaron

    2017-09-26

    De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37-43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing.

  10. Complicated diverticulitis in a de novo kidney transplanted patient.

    Science.gov (United States)

    TuŢă, Liliana Ana; Boşoteanu, Mădălina; Dumitru, Eugen; Deacu, Mariana

    2017-01-01

    Diverticular disease is frequent amongst the elderly and immunosuppressed patients. It mainly presents as sigmoid diverticulitis, but severe complications, like bleedings, infections and colon perforation may occur, frequently due to immunosuppressive therapy. Moreover, antibiotherapy and hemostatics may not efficiently control evolution in such cases. Early diagnose and adequate treatment of colonic diverticulosis complicated with lower gastrointestinal bleeding and diverticulitis in immunocompromised patients. We report a 55-year-old patient who underwent de novo renal transplantation one year ago and recently developed a severe diverticular bleeding complicated by hemorrhagic shock. Colonoscopic examination revealed diverticular disease with diverticulitis and severe, diffuse bleeding, mainly in the descending colon. Due to his immunocompromised status and unfavorable evolution under hemostatics, recombinant coagulation factor VIIa (rFVIIa) was given to avoid surgery. The bleeding stopped after two doses of rFVIIa. Unfortunately, after three weeks, lower quadrant pain, tenderness, abdominal distention, and fever occurred, in spite of immunosuppressive drug changing and adequate conservative therapy. Abdominal computed tomography (CT) scan revealed complicated diverticulitis, so patient underwent surgery, with partial colectomy, followed by total recovery. In conclusion, diverticulosis coli complicated with lower gastrointestinal bleeding and diverticulitis in immunocompromised patients was for us a challenging diagnosis, as well as a therapeutic issue. Treatment options, usually based on our local resources and expertise, considered conservatory therapy as the first choice, keeping surgical maneuvers just as a rescue solution.

  11. De novo transcriptome assembly of a sour cherry cultivar, Schattenmorelle

    Directory of Open Access Journals (Sweden)

    Yeonhwa Jo

    2015-12-01

    Full Text Available Sour cherry (Prunus cerasus in the genus Prunus in the family Rosaceae is one of the most popular stone fruit trees worldwide. Of known sour cherry cultivars, the Schattenmorelle is a famous old sour cherry with a high amount of fruit production. The Schattenmorelle was selected before 1650 and described in the 1800s. This cultivar was named after gardens of the Chateau de Moreille in which the cultivar was initially found. In order to identify new genes and to develop genetic markers for sour cherry, we performed a transcriptome analysis of a sour cherry. We selected the cultivar Schattenmorelle, which is among commercially important cultivars in Europe and North America. We obtained 2.05 GB raw data from the Schattenmorelle (NCBI accession number: SRX1187170. De novo transcriptome assembly using Trinity identified 61,053 transcripts in which N50 was 611 bp. Next, we identified 25,585 protein coding sequences using TransDecoder. The identified proteins were blasted against NCBI's non-redundant database for annotation. Based on blast search, we taxonomically classified the obtained sequences. As a result, we provide the transcriptome of sour cherry cultivar Schattenmorelle using next generation sequencing.

  12. Simple Approach for De Novo Structural Identification of Mannose Trisaccharides

    Science.gov (United States)

    Hsu, Hsu Chen; Liew, Chia Yen; Huang, Shih-Pei; Tsai, Shang-Ting; Ni, Chi-Kung

    2017-12-01

    Oligosaccharides have diverse functions in biological systems. However, the structural determination of oligosaccharides remains difficult and has created a bottleneck in carbohydrate research. In this study, a new approach for the de novo structural determination of underivatized oligosaccharides is demonstrated. A low-energy collision-induced dissociation (CID) of sodium ion adducts was used to facilitate the cleavage of desired chemical bonds during the dissociation. The selection of fragments for the subsequent CID was guided using a procedure that we built from the understanding of the saccharide dissociation mechanism. The linkages, anomeric configurations, and branch locations of oligosaccharides were determined by comparing the CID spectra of oligosaccharide with the fragmentation patterns based on the dissociation mechanism and our specially prepared disaccharide CID spectrum database. The usefulness of this method was demonstrated to determine the structures of several mannose trisaccharides. This method can also be applied in the structural determination of oligosaccharides larger than trisaccharides and containing hexose other than mannose if authentic standards are available. [Figure not available: see fulltext.

  13. Programming peptidomimetic syntheses by translating genetic codes designed de novo.

    Science.gov (United States)

    Forster, Anthony C; Tan, Zhongping; Nalam, Madhavi N L; Lin, Hening; Qu, Hui; Cornish, Virginia W; Blacklow, Stephen C

    2003-05-27

    Although the universal genetic code exhibits only minor variations in nature, Francis Crick proposed in 1955 that "the adaptor hypothesis allows one to construct, in theory, codes of bewildering variety." The existing code has been expanded to enable incorporation of a variety of unnatural amino acids at one or two nonadjacent sites within a protein by using nonsense or frameshift suppressor aminoacyl-tRNAs (aa-tRNAs) as adaptors. However, the suppressor strategy is inherently limited by compatibility with only a small subset of codons, by the ways such codons can be combined, and by variation in the efficiency of incorporation. Here, by preventing competing reactions with aa-tRNA synthetases, aa-tRNAs, and release factors during translation and by using nonsuppressor aa-tRNA substrates, we realize a potentially generalizable approach for template-encoded polymer synthesis that unmasks the substantially broader versatility of the core translation apparatus as a catalyst. We show that several adjacent, arbitrarily chosen sense codons can be completely reassigned to various unnatural amino acids according to de novo genetic codes by translating mRNAs into specific peptide analog polymers (peptidomimetics). Unnatural aa-tRNA substrates do not uniformly function as well as natural substrates, revealing important recognition elements for the translation apparatus. Genetic programming of peptidomimetic synthesis should facilitate mechanistic studies of translation and may ultimately enable the directed evolution of small molecules with desirable catalytic or pharmacological properties.

  14. De novo transcriptome assembly of mangosteen (Garcinia mangostana L. fruit

    Directory of Open Access Journals (Sweden)

    Deden Derajat Matra

    2016-12-01

    Full Text Available Garcinia mangostana L. (Mangosteen, of the family Clusiaceae, is one of the economically important tropical fruits in Indonesia. In the present study, we performed de novo transcriptomic analysis of Garcinia mangostana L. through RNA-Seq technology. We obtained the raw data from 12 libraries through Ion Proton System. Clean reads of 191,735,809 were obtained from 307,634,890 raw reads. The raw data obtained in this study can be accessible in DDBJ database with accession number of DRA005014 with bioproject accession number of PRJDB5091. We obtained 268,851 transcripts as well as 155,850 unigenes, having N50 value of 555 and 433 bp, respectively. Transcript/unigene length ranged from 201 to 5916 bp. The unigenes were annotated with two main databases from NCBI and UniProtKB, respectively having annotated-sequences of 73,287 and 73,107, respectively. These transcriptomic data will be beneficial for studying transcriptome of Garcinia mangostana L.

  15. Simple Approach for De Novo Structural Identification of Mannose Trisaccharides

    Science.gov (United States)

    Hsu, Hsu Chen; Liew, Chia Yen; Huang, Shih-Pei; Tsai, Shang-Ting; Ni, Chi-Kung

    2018-03-01

    Oligosaccharides have diverse functions in biological systems. However, the structural determination of oligosaccharides remains difficult and has created a bottleneck in carbohydrate research. In this study, a new approach for the de novo structural determination of underivatized oligosaccharides is demonstrated. A low-energy collision-induced dissociation (CID) of sodium ion adducts was used to facilitate the cleavage of desired chemical bonds during the dissociation. The selection of fragments for the subsequent CID was guided using a procedure that we built from the understanding of the saccharide dissociation mechanism. The linkages, anomeric configurations, and branch locations of oligosaccharides were determined by comparing the CID spectra of oligosaccharide with the fragmentation patterns based on the dissociation mechanism and our specially prepared disaccharide CID spectrum database. The usefulness of this method was demonstrated to determine the structures of several mannose trisaccharides. This method can also be applied in the structural determination of oligosaccharides larger than trisaccharides and containing hexose other than mannose if authentic standards are available.

  16. De novo transcriptome of the Hemimetabolous German cockroach (Blattella germanica.

    Directory of Open Access Journals (Sweden)

    Xiaojie Zhou

    Full Text Available BACKGROUND: The German cockroach, Blattella germanica, is an important insect pest that transmits various pathogens mechanically and causes severe allergic diseases. This insect has long served as a model system for studies of insect biology, physiology and ecology. However, the lack of genome or transcriptome information heavily hinder our further understanding about the German cockroach in every aspect at a molecular level and on a genome-wide scale. To explore the transcriptome and identify unique sequences of interest, we subjected the B. germanica transcriptome to massively parallel pyrosequencing and generated the first reference transcriptome for B. germanica. METHODOLOGY/PRINCIPAL FINDINGS: A total of 1,365,609 raw reads with an average length of 529 bp were generated via pyrosequencing the mixed cDNA library from different life stages of German cockroach including maturing oothecae, nymphs, adult females and males. The raw reads were de novo assembled to 48,800 contigs and 3,961 singletons with high-quality unique sequences. These sequences were annotated and classified functionally in terms of BLAST, GO and KEGG, and the genes putatively coding detoxification enzyme systems, insecticide targets, key components in systematic RNA interference, immunity and chemoreception pathways were identified. A total of 3,601 SSRs (Simple Sequence Repeats loci were also predicted. CONCLUSIONS/SIGNIFICANCE: The whole transcriptome pyrosequencing data from this study provides a usable genetic resource for future identification of potential functional genes involved in various biological processes.

  17. Sequencing and De Novo Transcriptome Assembly of Brachypodium sylvaticum (Poaceae

    Directory of Open Access Journals (Sweden)

    Samuel E. Fox

    2013-03-01

    Full Text Available Premise of the study: We report the de novo assembly and characterization of the transcriptomes of Brachypodium sylvaticum (slender false-brome accessions from native populations of Spain and Greece, and an invasive population west of Corvallis, Oregon, USA. Methods and Results: More than 350 million sequence reads from the mRNA libraries prepared from three B. sylvaticum genotypes were assembled into 120,091 (Corvallis, 104,950 (Spain, and 177,682 (Greece transcript contigs. In comparison with the B. distachyon Bd21 reference genome and GenBank protein sequences, we estimate >90% exome coverage for B. sylvaticum. The transcripts were assigned Gene Ontology and InterPro annotations. Brachypodium sylvaticum sequence reads aligned against the Bd21 genome revealed 394,654 single-nucleotide polymorphisms (SNPs and >20,000 simple sequence repeat (SSR DNA sites. Conclusions: To our knowledge, this is the first report of transcriptome sequencing of invasive plant species with a closely related sequenced reference genome. The sequences and identified SNP variant and SSR sites will provide tools for developing novel genetic markers for use in genotyping and characterization of invasive behavior of B. sylvaticum.

  18. Considerações sobre novos rumos para o Direito

    Directory of Open Access Journals (Sweden)

    Aristides Cimadon

    2010-07-01

    Full Text Available Neste artigo polemiza-se a prática judiciária e jurídica fundamentada no positivismo. Aborda-se uma crítica sobre as ações dos operadores jurídicos que se fundamentam na razão ornamental e no jeito. Reclama-se por uma produção jurídica ligada ao Direito Justo a serviço da cidadania e da sociedade. Mostra-se que a uma crise sintomática na produção das leis que, em geral, não tem preocupação com o bem-estar coletivo. Identifica-se a globalização de valores e relações econômicas que definem um conjunto de princípios reguladores da produção normativa. Por outro lado, questiona-se a ética e a moral como inspiração da operação jurídica e a necessidade de que a formação jurídica se paute por novos rumos que vislumbrem a Justiça como objetivo essencial do Direito. Palavras-chave: Direito. Justiça. Ética. Moral. Cidadania.

  19. De novo pericentric inversion of chromosome 9 in congenital anomaly.

    Science.gov (United States)

    Jeong, Seon-Yong; Kim, Bo-Young; Yu, Jae Eun

    2010-09-01

    The pericentric inversion of chromosome 9 is one of the most common structural balanced chromosomal variations and has been found in both normal populations and patients with various abnormal phenotypes and diseases. The aim of this study was to re-evaluate the clinical impact of inv(9)(p11q13). We studied the karyotypes of 431 neonates with congenital anomalies at the Pediatric Clinic in Ajou University Hospital between 2004 and 2008 and retrospectively reviewed their clinical data. Chromosomal aberrations were detected in 60 patients (13.9%). The most common type of structural abnormality was inv(9)(p11q13), found in eight patients. Clinical investigation revealed that all eight cases with inv(9)(p11q13) had various congenital anomalies including: polydactyly, club foot, microtia, deafness, asymmetric face, giant Meckel's diverticulum, duodenal diaphragm, small bowel malrotation, pulmonary stenosis, cardiomyopathy, arrhythmia, and intrauterine growth restriction. The cytogenetic analysis of parents showed that all of the cases were de novo heterozygous inv(9)(p11q13). Since our results indicate that the incidence of inv(9)(p11q13) in patients with congenital anomalies was not significantly different from the normal population, inv(9)(p11q13) does not appear to be pathogenic with regard to the congenital anomalies. Some other, to date unknown, causes of the anomalies remain to be identified.

  20. Spaced Seed Data Structures for De Novo Assembly

    Directory of Open Access Journals (Sweden)

    Inanç Birol

    2015-01-01

    Full Text Available De novo assembly of the genome of a species is essential in the absence of a reference genome sequence. Many scalable assembly algorithms use the de Bruijn graph (DBG paradigm to reconstruct genomes, where a table of subsequences of a certain length is derived from the reads, and their overlaps are analyzed to assemble sequences. Despite longer subsequences unlocking longer genomic features for assembly, associated increase in compute resources limits the practicability of DBG over other assembly archetypes already designed for longer reads. Here, we revisit the DBG paradigm to adapt it to the changing sequencing technology landscape and introduce three data structure designs for spaced seeds in the form of paired subsequences. These data structures address memory and run time constraints imposed by longer reads. We observe that when a fixed distance separates seed pairs, it provides increased sequence specificity with increased gap length. Further, we note that Bloom filters would be suitable to implicitly store spaced seeds and be tolerant to sequencing errors. Building on this concept, we describe a data structure for tracking the frequencies of observed spaced seeds. These data structure designs will have applications in genome, transcriptome and metagenome assemblies, and read error correction.

  1. De Novo Assembly and Characterization of the Xenocatantops brachycerus Transcriptome

    Science.gov (United States)

    Zhang, Xinmei; Qiu, Zhongying; Huang, Yuan

    2018-01-01

    Grasshoppers are common pests but also have high nutritional and commercial potential. Xenocatantops brachycerus Willemse (Orthoptera: Acrididae) is an economically important grasshopper species that is reared in China. Using the IlluminaHiSeqTM 4000 platform, three transcriptomes of the adult male, adult female, and nymph of X. brachycerus were sequenced. A total of 133,194,848 clean reads were obtained and de novo assembled into 43,187 unigenes with an average length of 964 bp (N50 of 1799 bp); of these, 24,717 (57.23%) unigenes matched known proteins. Based on these annotations, many putative transcripts related to X. brachycerus growth, development, environmental adaptability, and metabolism of nutritional components and bioactive components were identified. In addition, the expression profiles of all three transcriptome datasets were analyzed, and many differentially expressed genes were detected using RSEM and PossionDis. Unigenes. Unigenes with functions associated with growth and development exhibited higher transcript levels at the nymph stage, and unigenes associated with environmental adaptability showed increased transcription in the adults. These comprehensive X. brachycerus transcriptomic data will provide a useful molecular resource for gene prediction, molecular marker development, and studies on signaling pathways in this species and will serve as a reference for the efficient use of other grasshoppers. PMID:29419810

  2. Dominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome.

    Science.gov (United States)

    Boyden, Lynn M; Kam, Chen Y; Hernández-Martín, Angela; Zhou, Jing; Craiglow, Brittany G; Sidbury, Robert; Mathes, Erin F; Maguiness, Sheilagh M; Crumrine, Debra A; Williams, Mary L; Hu, Ronghua; Lifton, Richard P; Elias, Peter M; Green, Kathleen J; Choate, Keith A

    2016-01-15

    Disorders of keratinization (DOK) show marked genotypic and phenotypic heterogeneity. In most cases, disease is primarily cutaneous, and further clinical evaluation is therefore rarely pursued. We have identified subjects with a novel DOK featuring erythrokeratodermia and initially-asymptomatic, progressive, potentially fatal cardiomyopathy, a finding not previously associated with erythrokeratodermia. We show that de novo missense mutations clustered tightly within a single spectrin repeat of DSP cause this novel cardio-cutaneous disorder, which we term erythrokeratodermia-cardiomyopathy (EKC) syndrome. We demonstrate that DSP mutations in our EKC syndrome subjects affect localization of desmosomal proteins and connexin 43 in the skin, and result in desmosome aggregation, widening of intercellular spaces, and lipid secretory defects. DSP encodes desmoplakin, a primary component of desmosomes, intercellular adhesion junctions most abundant in the epidermis and heart. Though mutations in DSP are known to cause other disorders, our cohort features the unique clinical finding of severe whole-body erythrokeratodermia, with distinct effects on localization of desmosomal proteins and connexin 43. These findings add a severe, previously undescribed syndrome featuring erythrokeratodermia and cardiomyopathy to the spectrum of disease caused by mutation in DSP, and identify a specific region of the protein critical to the pathobiology of EKC syndrome and to DSP function in the heart and skin. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  3. LESSONS IN DE NOVO PEPTIDE SEQUENCING BY TANDEM MASS SPECTROMETRY

    Science.gov (United States)

    Medzihradszky, Katalin F.; Chalkley, Robert J.

    2015-01-01

    Mass spectrometry has become the method of choice for the qualitative and quantitative characterization of protein mixtures isolated from all kinds of living organisms. The raw data in these studies are MS/MS spectra, usually of peptides produced by proteolytic digestion of a protein. These spectra are “translated” into peptide sequences, normally with the help of various search engines. Data acquisition and interpretation have both been automated, and most researchers look only at the summary of the identifications without ever viewing the underlying raw data used for assignments. Automated analysis of data is essential due to the volume produced. However, being familiar with the finer intricacies of peptide fragmentation processes, and experiencing the difficulties of manual data interpretation allow a researcher to be able to more critically evaluate key results, particularly because there are many known rules of peptide fragmentation that are not incorporated into search engine scoring. Since the most commonly used MS/MS activation method is collision-induced dissociation (CID), in this article we present a brief review of the history of peptide CID analysis. Next, we provide a detailed tutorial on how to determine peptide sequences from CID data. Although the focus of the tutorial is de novo sequencing, the lessons learned and resources supplied are useful for data interpretation in general. PMID:25667941

  4. A crise financeira global e depois: um novo capitalismo?

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Bresser-Pereira

    2010-03-01

    Full Text Available A crise financeira global de 2008 foi conseqüência do processo de financeirização, a criação maciça de riqueza financeira fictícia iniciada da década de 1980, e da hegemonia de uma ideologia reacionária, o neoliberalismo, baseada em mercados auto-regulados e eficientes. Dessa crise emergirá um novo capitalismo, embora sua natureza seja de difícil previsão. Não será financeirizado, mas serão retomadas as tendências presentes nos trinta anos dourados em direção ao capitalismo global e baseado no conhecimento, além da tendência de expansão da democracia, tornando-a mais social e participativa.The 2008 global financial crisis was a consequence of the processes of financialization, the massive creation of fictitious financial wealth which began in the 1980's, and of the hegemony of a reactionary ideology, neoliberalism, based on the belief of the self-regulating capacity and efficiency of markets. From this crisis a new capitalism will emerge, althought its chacarteristics are hard to foresee. It will not be financial, but the tendencies of the 30 "golden years" toward global and knowledge-based capitalism, and the tendency of expansion of democracy will be among them.

  5. De Novo Design of Bioactive Small Molecules by Artificial Intelligence.

    Science.gov (United States)

    Merk, Daniel; Friedrich, Lukas; Grisoni, Francesca; Schneider, Gisbert

    2018-01-01

    Generative artificial intelligence offers a fresh view on molecular design. We present the first-time prospective application of a deep learning model for designing new druglike compounds with desired activities. For this purpose, we trained a recurrent neural network to capture the constitution of a large set of known bioactive compounds represented as SMILES strings. By transfer learning, this general model was fine-tuned on recognizing retinoid X and peroxisome proliferator-activated receptor agonists. We synthesized five top-ranking compounds designed by the generative model. Four of the compounds revealed nanomolar to low-micromolar receptor modulatory activity in cell-based assays. Apparently, the computational model intrinsically captured relevant chemical and biological knowledge without the need for explicit rules. The results of this study advocate generative artificial intelligence for prospective de novo molecular design, and demonstrate the potential of these methods for future medicinal chemistry. © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  6. Molecular de-novo design through deep reinforcement learning.

    Science.gov (United States)

    Olivecrona, Marcus; Blaschke, Thomas; Engkvist, Ola; Chen, Hongming

    2017-09-04

    This work introduces a method to tune a sequence-based generative model for molecular de novo design that through augmented episodic likelihood can learn to generate structures with certain specified desirable properties. We demonstrate how this model can execute a range of tasks such as generating analogues to a query structure and generating compounds predicted to be active against a biological target. As a proof of principle, the model is first trained to generate molecules that do not contain sulphur. As a second example, the model is trained to generate analogues to the drug Celecoxib, a technique that could be used for scaffold hopping or library expansion starting from a single molecule. Finally, when tuning the model towards generating compounds predicted to be active against the dopamine receptor type 2, the model generates structures of which more than 95% are predicted to be active, including experimentally confirmed actives that have not been included in either the generative model nor the activity prediction model. Graphical abstract .

  7. O Custo Meta no Desenvolvimento de Novos Produtos: um caso em indústria de conserva de pescadoThe Target Cost in New Product Development: a case study in the canned fish industryEl Costo Meta en el Desarrollo de Nuevos Productos: un caso en industria de conserva de pescado

    Directory of Open Access Journals (Sweden)

    CARDOSO, Rodrigo dos Santos

    2006-09-01

    Full Text Available RESUMOO artigo tem como objetivo demonstrar a utilização da metodologia do custo meta em uma indústria de conserva de pescado quando do lançamento de um novo líquido de cobertura, que se caracteriza neste ramo como um novo produto. Assim, realizou-se uma pesquisa exploratória, por meio da análise de um caso, com abordagem predominantemente qualitativa. Procurou-se inicialmente propiciar a conceituação da metodologia do custo meta ou alvo e sua principal ferramenta, a engenharia de valor. Em seguida, demonstra-se a aplicação desta metodologia em um caso de desenvolvimento de novo produto em uma indústria de conserva de pescado. Os resultados da pesquisa evidenciam a viabilidade da utilização da metodologia do custo meta neste seguimento de produto, com vistas ao atendimento das exigências do mercado consumidor.ABSTRACTThe present work has the objective of demonstrating the use of target cost methodology in a canned fish industry in the launching of new liquid topping, which is a new product in the field. An exploratory research was made by a case study with qualitative approach. At first the concept of the target cost methodology was provided, the value engineering. Then the implementation of such methodology was demonstrated in a product development case study in a canned fish industry. The results of the research evidenced the viability of the use of the target cost methodology in the product field, in order to attempt to the market exigencies.RESUMENEl artículo tiene por finalidad demostrar el uso de la metodología del costo meta en una industria de conservas de pescado cuando se realizó el lanzamiento de un nuevo líquido de cobertura, que en este ramo se considera un producto nuevo. Para esto se realizó una investigación exploratoria, por medio del análisis de un caso, con planteamiento predominantemente cualitativo. Inicialmente se buscó propiciar la conceptuación de la metodología del costo meta y su principal

  8. Automated Antibody De Novo Sequencing and Its Utility in Biopharmaceutical Discovery

    Science.gov (United States)

    Sen, K. Ilker; Tang, Wilfred H.; Nayak, Shruti; Kil, Yong J.; Bern, Marshall; Ozoglu, Berk; Ueberheide, Beatrix; Davis, Darryl; Becker, Christopher

    2017-05-01

    Applications of antibody de novo sequencing in the biopharmaceutical industry range from the discovery of new antibody drug candidates to identifying reagents for research and determining the primary structure of innovator products for biosimilar development. When murine, phage display, or patient-derived monoclonal antibodies against a target of interest are available, but the cDNA or the original cell line is not, de novo protein sequencing is required to humanize and recombinantly express these antibodies, followed by in vitro and in vivo testing for functional validation. Availability of fully automated software tools for monoclonal antibody de novo sequencing enables efficient and routine analysis. Here, we present a novel method to automatically de novo sequence antibodies using mass spectrometry and the Supernovo software. The robustness of the algorithm is demonstrated through a series of stress tests.

  9. A ORIGEM DOS PRESBÍTEROS-EPÍSCOPOS NA IGREJA DO NOVO TESTAMENTO (I

    Directory of Open Access Journals (Sweden)

    Antonio José de Almeida

    2000-01-01

    Full Text Available O presente estudo propõe-se a investigar a origem do ministério episcopal, na medida em que é observável nos escritos do Novo Testamento. Depois de uma breve introdução metodológica, recolhem-se sinteticamente as principais informações do Novo Testamento sobre os ministérios eclesiais, em sua totalidade, diversidade e unidade.

  10. De novo nonsense mutations in ASXL1 cause Bohring-Opitz syndrome

    DEFF Research Database (Denmark)

    Hoischen, Alexander; van Bon, Bregje W M; Rodríguez-Santiago, Benjamín

    2011-01-01

    Bohring-Opitz syndrome is characterized by severe intellectual disability, distinctive facial features and multiple congenital malformations. We sequenced the exomes of three individuals with Bohring-Opitz syndrome and in each identified heterozygous de novo nonsense mutations in ASXL1, which...... is required for maintenance of both activation and silencing of Hox genes. In total, 7 out of 13 subjects with a Bohring-Opitz phenotype had de novo ASXL1 mutations, suggesting that the syndrome is genetically heterogeneous....

  11. Utopia, distopia e realidade: um novo verismo na literatura para jovens

    Directory of Open Access Journals (Sweden)

    Valente, Thiago Alves

    2010-01-01

    Full Text Available Gênero visado como veículo de “formação” do jovem, a literatura infanto-juvenil muitas vezes torna-se alvo da busca por elementos de uma sociedade utópica. Porém, justamente por se tratar de Literatura, o gênero abre-se a outras possibilidades de vivência da realidade, seja esta compreendida pelo seu mundo mais subjetivo, seja ampliada a questões em escala mundial. Algumas obras inscritas no Programa Nacional Biblioteca da Escola (PNBE sinalizam caminhos da ficção para jovens nos anos 2000, dentre eles, o verismo e a utopia relidos por meio de novas propostas estéticas

  12. Breast and ovarian cancer predisposition due to de novo BRCA1 and BRCA2 mutations.

    Science.gov (United States)

    Golmard, L; Delnatte, C; Laugé, A; Moncoutier, V; Lefol, C; Abidallah, K; Tenreiro, H; Copigny, F; Giraudeau, M; Guy, C; Barbaroux, C; Amorim, G; Briaux, A; Guibert, V; Tarabeux, J; Caputo, S; Collet, A; Gesta, P; Ingster, O; Stern, M-H; Rouleau, E; de Pauw, A; Gauthier-Villars, M; Buecher, B; Bézieau, S; Stoppa-Lyonnet, D; Houdayer, C

    2016-03-10

    BRCA1 and BRCA2 are the two major genes predisposing to breast and ovarian cancer. Whereas high de novo mutation rates have been demonstrated for several genes, only 11 cases of de novo BRCA1/2 mutations have been reported to date and the BRCA1/2 de novo mutation rate remains unknown. The present study was designed to fill this gap based on a series of 12 805 consecutive unrelated patients diagnosed with breast and/or ovarian cancer who met the inclusion criteria for BRCA1/2 gene analysis according to French guidelines. BRCA1/2 mutations were detected in 1527 (12%) patients, and three BRCA1 mutations and one BRCA2 mutation were de novo. The BRCA1/2 de novo mutation rate was estimated to be 0.3% (0.1%; 0.7%). Although rare, it may be useful to take the possibility of de novo BRCA1/2 mutation into account in genetic counseling of relatives and to improve the understanding of complex family histories of breast and ovarian cancers.

  13. Association between diabetes mellitus and tuberculosis in United States-born and foreign-born populations in San Francisco.

    Directory of Open Access Journals (Sweden)

    Gompol Suwanpimolkul

    Full Text Available The impact of diabetes on tuberculosis in United States and foreign-born populations in San Francisco has not been studied.To determine the characteristics, prevalence and temporal trends of diabetes in US and foreign-born persons attending the San Francisco Tuberculosis Clinic.We analyzed data from individuals seeking medical attention at the San Francisco Tuberculosis Clinic. We included patients with diagnosis of tuberculosis, latent infection, or not infected with Mycobacterium tuberculosis. We assessed the temporal trend and the characteristics of individuals with and without diabetes.Between 2005 and 2012, there were 4371 (19.0% individuals without evidence of tuberculosis infection, 17,856 (77.6% with latent tuberculosis, and 791 (3.4% with tuberculosis. 66% were born in the United States, China, Mexico, and the Philippines. The prevalence of diabetes was the highest among individuals with tuberculosis and increased during the study period. Patients with tuberculosis and diabetes were more likely to be male, older than 45 years and born in the Philippines. There was a disproportionate association of TB and DM relative to LTBI and DM among Filipinos in individuals older than 45 years old.Our data suggest that Filipinos older than 45 years old are more likely to have tuberculosis probably due to a higher prevalence of diabetes. In San Francisco, tuberculosis-screening programs in individuals with diabetes and latent tuberculosis may be beneficial in patients older than 45 years old especially from the Philippines.

  14. San Francisco earthquake of April 18th, 1906, a hundred-year anniversary of disastrous Californian event

    Czech Academy of Sciences Publication Activity Database

    Kozák, Jan

    2006-01-01

    Roč. 50, č. 2 (2006), s. 319-321 ISSN 0039-3169 Institutional research plan: CEZ:AV0Z30120515 Keywords : earthquake * San Francisco 1906 * history of seismology Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 0.603, year: 2006

  15. Risk Behaviors among Asian Women Who Work at Massage Parlors in San Francisco: Perspectives from Masseuses and Owners/Managers

    Science.gov (United States)

    Nemoto, Tooru; Iwamoto, Mariko; Oh, Hyun Joo; Wong, Serena; Nguyen, Hongmai

    2005-01-01

    This study investigates cognitive, cultural, and contextual factors that influence HIV-related risk behaviors among Asian women who engage in sex work at massage parlors in San Francisco. Focus groups and qualitative interviews were conducted for Vietnamese and Thai masseuses and massage parlor owners/managers. Economic pressure as well as…

  16. Association between diabetes mellitus and tuberculosis in United States-born and foreign-born populations in San Francisco.

    Science.gov (United States)

    Suwanpimolkul, Gompol; Grinsdale, Jennifer A; Jarlsberg, Leah G; Higashi, Julie; Osmond, Dennis H; Hopewell, Philip C; Kato-Maeda, Midori

    2014-01-01

    The impact of diabetes on tuberculosis in United States and foreign-born populations in San Francisco has not been studied. To determine the characteristics, prevalence and temporal trends of diabetes in US and foreign-born persons attending the San Francisco Tuberculosis Clinic. We analyzed data from individuals seeking medical attention at the San Francisco Tuberculosis Clinic. We included patients with diagnosis of tuberculosis, latent infection, or not infected with Mycobacterium tuberculosis. We assessed the temporal trend and the characteristics of individuals with and without diabetes. Between 2005 and 2012, there were 4371 (19.0%) individuals without evidence of tuberculosis infection, 17,856 (77.6%) with latent tuberculosis, and 791 (3.4%) with tuberculosis. 66% were born in the United States, China, Mexico, and the Philippines. The prevalence of diabetes was the highest among individuals with tuberculosis and increased during the study period. Patients with tuberculosis and diabetes were more likely to be male, older than 45 years and born in the Philippines. There was a disproportionate association of TB and DM relative to LTBI and DM among Filipinos in individuals older than 45 years old. Our data suggest that Filipinos older than 45 years old are more likely to have tuberculosis probably due to a higher prevalence of diabetes. In San Francisco, tuberculosis-screening programs in individuals with diabetes and latent tuberculosis may be beneficial in patients older than 45 years old especially from the Philippines.

  17. Affective foodscapes in an economy of passion : repetition, opposition and adaptation in Mexican restaurants in Amsterdam, Madrid and San Francisco

    NARCIS (Netherlands)

    Matus Ruiz, M.

    2012-01-01

    The
 main
 goal
 of
 my
 research
 was
 to
 analyze
 how
 the
 desire
 to
 affect
 and
 be
 affected
 by
 foreign
 signs
relates
 to
 the
 commoditization
 of
 food
 products
 offered
 in
 Mexican
 restaurants
 in
 Amsterdam,
 Madrid
and
 San
 Francisco.
 I
 conceive
 restaurants
 as


  18. Un documento inedito: Historia de Sebastián de Belalcázar, escrita por su hijo, Don Francisco

    Directory of Open Access Journals (Sweden)

    Juán Friede

    1964-04-01

    Full Text Available El documento que publicamos, inédito hasta ahora es una breve historia de Sebastián de Belalcázar, gobernador de Popayán, muerto en 1550, escrita por su hijo dos Francisco hacia 1557, cuando se encontraba en España.

  19. Identifying Telemedicine Services to Improve Access to Specialty Care for the Underserved in the San Francisco Safety Net

    Directory of Open Access Journals (Sweden)

    Ken Russell Coelho

    2011-01-01

    Full Text Available Safety-net settings across the country have grappled with providing adequate access to specialty care services. San Francisco General Hospital and Trauma Center, serving as the city's primary safety-net hospital, has also had to struggle with the same issue. With Healthy San Francisco, the City and County of San Francisco's Universal Healthcare mandate, the increased demand for specialty care services has placed a further strain on the system. With the recent passage of California Proposition 1D, infrastructural funds are now set aside to assist in connecting major hospitals with primary care clinics in remote areas all over the state of California, using telemedicine. Based on a selected sample of key informant interviews with local staff physicians, this study provides further insight into the current process of e-referral which uses electronic communication for making referrals to specialty care. It also identifies key services for telemedicine in primary and specialty care settings within the San Francisco public health system. This study concludes with proposals for a framework that seek to increase collaboration between the referring primary care physician and specialist, to prioritize institution of these key services for telemedicine.

  20. Christopher Columbus, Hernando Cortes, and Francisco Pizzaro: A Qualitative Content Analysis Examining Cultural Bias in World History Textbooks

    Science.gov (United States)

    Lillejord, Jebadiah Serril

    2013-01-01

    The purpose of this study is to investigate to what extent contemporary high school world history textbooks portray Christopher Columbus, Hernán Cortés, and Francisco Pizarro within the context of being "sacred," "profane," or someplace in between. To evaluate for existence of content bias this study employed qualitative…

  1. Tap water isotopes reveal the San Francisco Bay Area's plumbing and responses to a major drought

    Science.gov (United States)

    Tipple, B. J.; Jameel, M. Y.; Chau, T. H.; Mancuso, C. J.; Bowen, G. J.; Dufour, A.; Chesson, L. A.; Ehleringer, J. R.

    2016-12-01

    Water availability and sustainability in the Western United States is a major flashpoint among expanding communities, growing industries, and productive agricultural lands. This issue came to a head in 2015 in the State of California, when the State mandated a 25% reduction in urban water use following a multi-year drought that significantly depleted water resources. The demands for and challenges in supplying water are only expected to intensify as climate perturbations, such as the 2012-2015 California Drought, become more common. As a consequence, there is an increased need to understand linkages between population centers, water transport and usage, and the impacts of climate change on water resources and infrastructure. To better understand these relationships within a megalopolis in the Western United States, we collected and analyzed 723 tap waters from the San Francisco Bay Area during seven collection campaigns across 21 months during 2013-2015. San Francisco Bay Area was selected as it has well-known water management strategies and its water resources were dramatically affected by the 2012-2105 drought. Consistent with known water management strategies and previous reports of tap water isotope values, we found large spatiotemporal variations in the δ2H and δ18O values of tap waters, indicative of complex water transport systems and municipality-scale management decisions. We observed δ2H and δ18O values of tap water consistent with waters originating from snowmelt from the Sierra Nevada Mountains, local precipitation, ground water, and partially evaporated reservoir sources. A cluster analysis of measured tap water data grouped waters from 43 static sampling sites that were associated with specific water utility providers within the San Francisco Bay Area and known management practices. Water management responses to the drought, such as source switching, bringing in new sources, and conservation, could be observed within the isotope data from each of

  2. Talus Lex: Regulatory Approaches to Reducing Mercury Concentrations in San Francisco Bay Fish.

    Science.gov (United States)

    Abu-Saba, D. E.; Flegal, D. R.; Ganguli, P. M.; Whyte, D. C.; Mumley, D. E.; Mason, D. P.

    2001-12-01

    The history of mercury in California is recorded in the sediments of San Francisco Bay. The Bay is downstream of 40 percent of the land area of California. Its watershed receives 80 percent of the rainfall in the State, because it rains more in the north. Three billion kilograms of sediments are annually flushed from the Central Valley watershed and deposited in San Francisco Bay. Because mercury preferentially binds to sediments, we calculate mercury loads to the Bay by considering how various sources affect mercury concentrations in Bay sediments. During and after the Gold Rush, over seventy thousand tons of mercury was produced in Coast Range cinnabar mines. Much of this mercury was used as quicksilver to extract gold from placer formations in the Sierra foothills, and later in the production of munitions, electronics, health care and commercial products. Today, we can see the legacy of mining sources, from both remote and local watersheds, superimposed on air deposition, the climate and geography of California, heavily managed water supply and flood control projects, wetland restoration and rehabilitation, urbanization, wastewaster discharge and water reclamation. We already regulate wastewater and urban runoff through issuance of permits and waste discharge requirements. We can regulate mercury inputs from inoperative mines by demonstrating the link between mercury-polluted sediments and violation of existing numeric water quality objectives. We can use the same approach to regulate the disposal of mercury-containing electronic devices. But to reduce mercury levels in fish, we will also have to consider controllable water quality factors that promote mercury methylation in the aquatic ecosystem. Some of these water quality factors are already subject to regulation. For example, we can show that mercury methylation in the northern reach of the Bay increases when dissolved oxygen drops below 6 mg/L; current regulations require dissolved oxygen concentrations of

  3. De novo ORFs in Drosophila are important to organismal fitness and evolved rapidly from previously non-coding sequences.

    Directory of Open Access Journals (Sweden)

    Josephine A Reinhardt

    Full Text Available How non-coding DNA gives rise to new protein-coding genes (de novo genes is not well understood. Recent work has revealed the origins and functions of a few de novo genes, but common principles governing the evolution or biological roles of these genes are unknown. To better define these principles, we performed a parallel analysis of the evolution and function of six putatively protein-coding de novo genes described in Drosophila melanogaster. Reconstruction of the transcriptional history of de novo genes shows that two de novo genes emerged from novel long non-coding RNAs that arose at least 5 MY prior to evolution of an open reading frame. In contrast, four other de novo genes evolved a translated open reading frame and transcription within the same evolutionary interval suggesting that nascent open reading frames (proto-ORFs, while not required, can contribute to the emergence of a new de novo gene. However, none of the genes arose from proto-ORFs that existed long before expression evolved. Sequence and structural evolution of de novo genes was rapid compared to nearby genes and the structural complexity of de novo genes steadily increases over evolutionary time. Despite the fact that these genes are transcribed at a higher level in males than females, and are most strongly expressed in testes, RNAi experiments show that most of these genes are essential in both sexes during metamorphosis. This lethality suggests that protein coding de novo genes in Drosophila quickly become functionally important.

  4. Novos conceitos em cuidados paliativos na unidade de terapia intensiva

    Directory of Open Access Journals (Sweden)

    Cristina Bueno Terzi Coelho

    Full Text Available RESUMO Alguns dos pacientes admitidos em uma unidade de terapia intensiva podem enfrentar condições de doença terminal, que geralmente levam à morte. O conhecimento sobre cuidados paliativos é recomendado para os profissionais de saúde encarregados do cuidado destes pacientes. Em muitas situações, os pacientes devem ser avaliados diariamente, já que a introdução de novos tratamentos pode ou não ser benéfica para eles. As discussões entre os membros da equipe de saúde, relacionadas ao prognóstico e aos objetivos do tratamento, devem ser avaliadas cuidadosamente em cooperação com os pacientes e seus familiares. A adoção na unidade de terapia intensiva de protocolos relacionados a pacientes em final da vida é fundamental. É importante ter uma equipe multidisciplinar para determinar se é necessário deixar de iniciar ou mesmo retirar tratamentos avançados. Além disto, pacientes e familiares devem ser informados de que os cuidados paliativos envolvem o melhor tratamento possível para aquela situação específica, assim como respeitar suas vontades e considerar as bases sociais e espirituais dos mesmos. Assim, o objetivo desta revisão foi apresentar os cuidados paliativos como uma opção razoável para dar suporte à equipe da unidade de terapia intensiva na assistência a pacientes com doença terminal. São apresentadas atualizações com relação a dieta, ventilação mecânica e diálise nestes pacientes. Ainda, discutiremos o programa, comum nos Estados Unidos, conhecido como filosofia hospice, como alternativa ao ambiente da unidade de terapia intensiva/hospital.

  5. Adversarial Threshold Neural Computer for Molecular de Novo Design.

    Science.gov (United States)

    Putin, Evgeny; Asadulaev, Arip; Vanhaelen, Quentin; Ivanenkov, Yan; Aladinskaya, Anastasia V; Aliper, Alex; Zhavoronkov, Alex

    2018-03-30

    In this article, we propose the deep neural network Adversarial Threshold Neural Computer (ATNC). The ATNC model is intended for the de novo design of novel small-molecule organic structures. The model is based on generative adversarial network architecture and reinforcement learning. ATNC uses a Differentiable Neural Computer as a generator and has a new specific block, called adversarial threshold (AT). AT acts as a filter between the agent (generator) and the environment (discriminator + objective reward functions). Furthermore, to generate more diverse molecules we introduce a new objective reward function named Internal Diversity Clustering (IDC). In this work, ATNC is tested and compared with the ORGANIC model. Both models were trained on the SMILES string representation of the molecules, using four objective functions (internal similarity, Muegge druglikeness filter, presence or absence of sp 3 -rich fragments, and IDC). The SMILES representations of 15K druglike molecules from the ChemDiv collection were used as a training data set. For the different functions, ATNC outperforms ORGANIC. Combined with the IDC, ATNC generates 72% of valid and 77% of unique SMILES strings, while ORGANIC generates only 7% of valid and 86% of unique SMILES strings. For each set of molecules generated by ATNC and ORGANIC, we analyzed distributions of four molecular descriptors (number of atoms, molecular weight, logP, and tpsa) and calculated five chemical statistical features (internal diversity, number of unique heterocycles, number of clusters, number of singletons, and number of compounds that have not been passed through medicinal chemistry filters). Analysis of key molecular descriptors and chemical statistical features demonstrated that the molecules generated by ATNC elicited better druglikeness properties. We also performed in vitro validation of the molecules generated by ATNC; results indicated that ATNC is an effective method for producing hit compounds.

  6. El sujeto enunciativo y sus espacios en algunos poemas de Francisco Hernández

    Directory of Open Access Journals (Sweden)

    Alejandro Palma Castro

    2015-07-01

    Full Text Available En este artículo se desarrolla un análisis del sujeto enunciativo en algunos poemas de Francisco Hernández para mostrar la importancia, pero también urgencia, de profundizar en los estudios de enunciación en el discurso poético. A partir de la poética de Hernández, particularmente sugerente en lo que respecta a la apropiación de personalidades o máscaras, propongo una metodología y tipología más adecuadas para extender las posibilidades de su interpretación y lectura desde los espacios que se perciben en el poema,a partir de la consideracióndel sujeto enunciativo, según algunos de los estudios críticos que existen a la fecha.

  7. Maps of Quaternary Deposits and Liquefaction Susceptibility in the Central San Francisco Bay Region, California

    Science.gov (United States)

    Witter, Robert C.; Knudsen, Keith L.; Sowers, Janet M.; Wentworth, Carl M.; Koehler, Richard D.; Randolph, Carolyn E.; Brooks, Suzanna K.; Gans, Kathleen D.

    2006-01-01

    This report presents a map and database of Quaternary deposits and liquefaction susceptibility for the urban core of the San Francisco Bay region. It supercedes the equivalent area of U.S. Geological Survey Open-File Report 00-444 (Knudsen and others, 2000), which covers the larger 9-county San Francisco Bay region. The report consists of (1) a spatial database, (2) two small-scale colored maps (Quaternary deposits and liquefaction susceptibility), (3) a text describing the Quaternary map and liquefaction interpretation (part 3), and (4) a text introducing the report and describing the database (part 1). All parts of the report are digital; part 1 describes the database and digital files and how to obtain them by downloading across the internet. The nine counties surrounding San Francisco Bay straddle the San Andreas fault system, which exposes the region to serious earthquake hazard (Working Group on California Earthquake Probabilities, 1999). Much of the land adjacent to the Bay and the major rivers and streams is underlain by unconsolidated deposits that are particularly vulnerable to earthquake shaking and liquefaction of water-saturated granular sediment. This new map provides a consistent detailed treatment of the central part of the 9-county region in which much of the mapping of Open-File Report 00-444 was either at smaller (less detailed) scale or represented only preliminary revision of earlier work. Like Open-File Report 00-444, the current mapping uses geomorphic expression, pedogenic soils, inferred depositional environments, and geologic age to define and distinguish the map units. Further scrutiny of the factors controlling liquefaction susceptibility has led to some changes relative to Open-File Report 00-444: particularly the reclassification of San Francisco Bay mud (Qhbm) to have only MODERATE susceptibility and the rating of artificial fills according to the Quaternary map units inferred to underlie them (other than dams - adf). The two colored

  8. Francisco Ibarra Martínez: renovador de la pedagogía cubana

    Directory of Open Access Journals (Sweden)

    Lic. Osmar Oliva-Crespo

    2015-10-01

    Full Text Available The article entitled Francisco Ibarra Martínez: reformer of Cuban Pedagogy, is first of all a well deserved homage to one of the most important pedagogues of the republican period. His thought and his work are approached, from his initial stage of academic formation to his contributions to the educational cuban thought. Stands out his social dimension of his pedagogic work, his integration to the civic life of the city, his reforming vision of the practice of sports and study of the history of his country. Likewise, we refer to his contributions to the historiography as a science, the journalism and his concern for the social and political destination of the country. For this reason this work has among its contributions the treatment to the local history from the specific fild of pedagogy and education, modestly contributing to the rescue of historic memory.

  9. Francisco Mejía: el testimonio de una sociedad que se complace

    Directory of Open Access Journals (Sweden)

    Carlos José Restrepo

    1986-10-01

    Full Text Available Hace unos dos años la familia Mejía donó al Faes (Fundación Antioqueña para los Estudios Sociales parte de los archivos fotográficos de Francisco Mejía (1899-1979, concretamente lo que podríamos llamar su archivo comercial en contraposición al de sus retratos de gabinete. Compuesto por unos siete mil negativos de diferentes materiales (vidrio, nitrato y acetato de celulosa, su calidad y variedad fueron motivo para que el Banco de la República resolviera apoyar el trabajo de identificación, procesamiento y preservación, labor llevada a cabo por el Centro de Memoria Visual de Medellín, que forma parte del Faes.

  10. Overcoming ERISA as an obstacle: the Ninth Circuit's approval of San Francisco's fair share legislation.

    Science.gov (United States)

    Antia, Mazda K; Polvino, Kathlynn Butler; Meservy, Heather C; Cramer, Payal Patel

    2009-07-01

    State and local legislatures in more than twenty states have considered enacting fair share laws. Fair share laws typically require employers of a certain size either to spend a designated percentage of their total payroll costs on health insurance for their employees or pay into a state fund for uninsured individuals. Such laws have been challenged in the federal courts, ultimately resulting in differing decisions. In 2007, the Fourth Circuit Court of Appeals affirmed the lower court's decision to strike down the Maryland Fair Share Act, holding it was preempted by the Employee Retirement Income Security Act (ERISA). The Fair Share for Health Care Act in Suffolk County, NewYork succumbed to a similar fate. However, in the Ninth Circuit, San Francisco's Health Care Security Ordinance survived ERISA preemption. This article analyzes the Fourth and Ninth Circuit decisions and explores the potential effects of the differing outcomes on healthcare reform.

  11. NA BACIA DO RIO SÃO FRANCISCO, EM MINAS GERAIS

    Directory of Open Access Journals (Sweden)

    Lucas Rezende Gomide

    2006-01-01

    Full Text Available The objectives of this study were: to compare and to apply indices that quantify diversity, equability and similarity in the studied area; to identify possible diversity gradients, and to apply multivariate analysis to create dendrograms of similarity. The studied area was composed of 20 native forest fragments sited in riparian permanent preservation areas along the basin of São Francisco River, in Minas Gerais. The diversity presented a large variation according to all indices: Shannon: 2,176 to 4,389; Simpson: 0,019 to 0,206; Mixture quotient: 0,029 to 0,166, Equability 0,625 to 0,875. The floristic similarity among fragments using the Jaccard and Simpson quotients formed 5 and 4 floristic groups, respectively, with a cut level of 25%.

  12. BRICKS, BRANDING, AND THE EVERYDAY: DEFINING GREATNESS AT THE UNITED NATIONS PLAZA IN SAN FRANCISCO

    Directory of Open Access Journals (Sweden)

    Georgia Lindsay

    2017-07-01

    Full Text Available After over a decade of reports, designs, and public outreach, the United Nations Plaza in San Francisco was dedicated in 1976. Using historical documents such as government reports, design guidelines, letters, meeting minutes, and newspaper articles from archives, I argue that while the construction of the UN Plaza has failed to completely transform the social and economic life of the area, it succeeds in creating a genuinely public space. The history of the UN Plaza can serve both as a cautionary tale for those interested in changing property values purely through changing design, and as a standard of success in making a space used by a true cross-section of urban society.

  13. Multiple types of childhood and adult violence among homeless and unstably housed women in San Francisco

    Science.gov (United States)

    Wong, Lauren H.; Shumway, Martha; Flentje, Annesa; Riley, Elise D.

    2017-01-01

    The present study examined the relationship between different forms of childhood violence (emotional, physical, and sexual) and these same forms of violence in adulthood, using a cross-sectional baseline survey of 298 homeless and unstably housed women in San Francisco, California. We also examined other related factors, including mental illnesses diagnosis, sex exchange, jail time, HIV status, and sociodemographic information. Regression analysis indicated that while several of these factors were associated with experiences of violence as an adult, specific types of child violence (e.g. sexual violence) predicted instances of that same type of violence as an adult, but not necessarily other types. Thus, risk of adult violence among low-income women may be better predicted and addressed through histories of same-type childhood violence, despite competing current stressors. PMID:27640925

  14. Cambio Institucional y liderazgo en el Estado Vaticano: de Benedicto XVI a Francisco

    OpenAIRE

    Gómez Botero, Juliana

    2015-01-01

    En 1965 se clausuró el Concilio Vaticano II que abrió las puertas de la iglesia Católica hacia la modernidad. La presente investigación examina los rasgos de liderazgo del Papa Francisco y la relación de éste con el cambio institucional en el Estado Vaticano; de ese modo se hará también una comparación entre las características comunes de los últimos dos pontífices y su repercusión en la toma de decisiones. Los resultados de este trabajo podrían ser importantes para quienes estén interesados ...

  15. Multiple Types of Childhood and Adult Violence Among Homeless and Unstably Housed Women in San Francisco.

    Science.gov (United States)

    Wong, Lauren H; Shumway, Martha; Flentje, Annesa; Riley, Elise D

    2016-12-01

    This study examined the relationship between different forms of childhood violence (emotional, physical, and sexual) and these same forms of violence in adulthood, using a crosssectional baseline survey of 298 homeless and unstably housed women in San Francisco, California. We also examined other related factors, including mental illnesses diagnosis, sex exchange, jail time, HIV status, and sociodemographic information. Regression analysis indicated that although several of these factors were associated with experiences of violence as an adult, specific types of child violence (e.g., sexual violence) predicted instances of that same type of violence as an adult but not necessarily other types. Thus, risk of adult violence among low-income women may be better predicted and addressed through histories of same-type childhood violence, despite years of intervening exposures and stressors.

  16. Hibridaciones de la crónica contemporánea. (textos de Francisco Mouat.

    Directory of Open Access Journals (Sweden)

    Patricia Poblete Alday

    2013-08-01

    Full Text Available Desde la obra cronística de Francisco Mouat, este artículo indaga acerca de la posición de este formato textual en la actualidad, principalmente desde las nociones de hibridez y autoría que suponen y cuestionan. Para este ejercicio, se propone una diferenciación entre la crónica de carácter más referencial o periodística (volcada al relato de sucesos reales, y aquella de corte más ensayístico o literario, que se vuelca sobre la interioridad del sujeto escritor, desde donde se asume una postura crítica tanto hacia el ethos posmoderno como hacia la propia escritura.

  17. Francisco de Miranda: Precursor de la independencia o espía al servicio de Inglaterra

    Directory of Open Access Journals (Sweden)

    Ángel Rafael Lombardi Boscán

    2006-09-01

    Full Text Available Francisco de Miranda es una de las grandes figuras emblemticas de la Historia de Venezuela. En nuestro medio le consideramos el adalid de la libertad continental en contra de la Monarquía hispnica. Hace doscientos años que intentó invadir a Venezuela y fracasó (1806; aunque contribuyó a crear las condiciones para la transición de colonia a republica. Aquí llevamos a cabo un acercamiento a su vida como conspirador bajo la dicotomía y paradoja de servir tanto a los intereses geopolíticos ingleses como a la causa de la libertad republicana.

  18. Diplomacy, Courtly Service and Catholic Inks: The London Lawsuit of Francisco de Melo Manuel

    Directory of Open Access Journals (Sweden)

    Cristina BRAVO LOZANO

    2017-06-01

    Full Text Available In 1676 Francisco de Melo, Portuguese ambassador in London and lord chamberlain of the Queen Catherine of Braganza, was involved in a typographic controversy that affected his diplomatic dignity and his palatine office. Service and obedience to two members of the Lusitanian Royal House, with different natures and responsibilities, show the delicate balance between the political sphere of negotiation and the domestic space. According to his career and his dual position, the impression’s permission of a catholic book in the protestant court caused the dispute analyzed in these pages. Although it can be interpreted as an eventual case, it emphasizes the confessional reality of England and how such printed texts found ways of diffusion through the diplomacy and the environment of the royal consort.

  19. Francisco Prat Puig: His pedagogical praxis at the Universidad de Oriente

    Directory of Open Access Journals (Sweden)

    María Cristina Hierrezuelo-Planas

    2017-05-01

    Full Text Available Doctor Francisco Prat Puig was one of the spanish intellectualist who sheltered in the Island of Cuba after the falling down of the Spanish Republic and in 1948 was part of the staff of professors of the recently founded Universidad de Oriente. He developed a teaching process which was centered on instruction through education and which followed the transmission and formation of values departing from his personal behavior and attitude. This took peace until his death in may, 1997. These aspect constitute one of the mastery strategies of the High Level Education Ministry of Cuba. The fact that most of his educational performance was done by the time when these aspect were not deeply applied, gives his pedagogical praxis a precursory character.

  20. What We Have Learned from San Francisco Declaration on Research Assessment and Leiden Manifesto?

    Directory of Open Access Journals (Sweden)

    Carey Ming-Li Chen

    2017-03-01

    Full Text Available In recent years, the research performance evaluation of members of the academic community conducted by government or institutions has been applied with multiple indicators and peer review, however, there are many controversies about the design and application of research evaluation indicators. This article aims to introduce the development process of San Francisco Declaration on Research Assessment (DORA and Leiden Manifesto and summarize their contents of guidelines and attempts to compare the differences between these two documents. It hopes that this article can arise the attention and reflection of research evaluation indicators and relevant issues from Taiwan academic community to reach consensus of utilization of research evaluation indicators. It will be beneficial to develop the version of declaration with local characteristics in the future.

  1. South San Francisco bay water quality modeling and waste load allocation study

    International Nuclear Information System (INIS)

    Wang, P.F.; Ambrose, R.B.; Novo-Gradac, K.K.

    1993-03-01

    A waste load allocation modeling study was conducted in South San Francisco Bay, California. Relatively numerous reports on hydrodynamics and less complete data for water quality, especially sediment levels, in the Bay were reviewed for use in the study. Simulations were based on the premise that sediments maintain equilibrium over long periods of time. Copper concentrations were simulated using different loading conditions describing different scenarios. Nontidal transport results were obtained for suspended solids, copper, nickel, and lead. The wide ranges of historical water quality data were addressed through sensitivity analysis of unsteady nonpoint source loads. For demonstration purposes, the domain for tidal simulations covered only the regions south of Dumbarton Bridge. The effects of the reduction of point-source loads over the past few years and of the droughts that began in 1987 were simulated using appropriate loading conditions

  2. User's guide to the LIRAQ model: an air pollution model for the San Francisco Bay Area

    International Nuclear Information System (INIS)

    MacCracken, M.C.

    1975-01-01

    The Livermore Regional Air Quality (LIRAQ) model comprises a set of computer programs that have been integrated into an easily used tool for the air quality planner. To assemble and modify the necessary data files and to direct model execution, a problem formulation program has been developed that makes possible the setup of a wide variety of studies involving perturbation of the emission inventory, changes to the initial and boundary conditions, and different choices of grid size and problem domain. In addition to describing the types of air quality problems for which the LIRAQ model may be used, this User's Guide provides detailed information on how to set up and conduct model simulations. Also included are descriptions of the formats of input data files so that the LIRAQ model may be applied to regions other than the San Francisco Bay Area

  3. Relação da expressão de fatores de crescimento celular (IGF-1 e (SCF com fatores prognósticos e o alvo da rapamicina em mamíferos (m-TOR em mastocitomas cutâneos caninos

    Directory of Open Access Journals (Sweden)

    Raquel B. Ferioli

    2013-04-01

    Full Text Available O mastocitoma cutâneo (MTC é a neoplasia maligna mais comum na pele dos cães e seu comportamento biológico é muito variável. Dentre os fatores prognósticos estudados nos MTCs, a classificação histopatológica, o índice proliferativo e o padrão de expressão doc-KIT são os que apresentam uma associação mais relevante com o provável prognóstico deste tumor. O objetivo deste trabalho foi avaliar a expressão proteica de fator de crescimento semelhante à insulina tipo 1 (IGF-1, fator de célula tronco (SCF e sua relação com o receptor tirosina quinase (c-KIT, alvo da rapamicina em mamíferos (m-TOR, grau histológico, índice proliferativo pelo KI-67e o número de figuras de mitose (IM com dados clínicos de cães com MTCs . Foram utilizadas 133 amostras de MTCs, provenientes de 133 cães, dispostas em lâminas de microarranjo de tecidos (TMA. A técnica de imuno-histoquímica foi utilizada para a avaliação destas proteínas. Observou-se associação entre SCF e, a graduação histopatológica proposta em 2011, índice mitótico, proliferação celular (KI-67, escore de IGF-1, local da lesão, idade dos animais e padrão imuno-histoquímico do receptor c-KIT. A relação de dependência também foi observada entre IGF-1 e o porte dos animais, IM, m-TOR e c-KIT. A expressão de SCF teve relacção com a agressividade dos MTCs caninos, uma vez que foi mais freqüente em MTCs com c-KIT citoplasmático. A relação entre a expressão de IGF-1, SCF, c-KIT e m-TOR pode estar associada à integralização de suas vias de ação. A expressão de IGF-1 está associada à MTCs em cães de porte grande.

  4. Religiosidad e identidad en San Francisco de Campeche. Siglos XVI y XVII

    Directory of Open Access Journals (Sweden)

    Rocher Salas, Adriana Delfina

    2006-12-01

    Full Text Available This study examines the problems concomitant to the development of a common identity among the Spanish settlers of San Francisco de Campeche during the Colonial period, with focus on the role played by religious elements in the shaping of this identity – in particular, the cult to the saints. An analysis of factors such as the characteristics of the saints in the neighborhood and local associations; processes of cult adoption, adaptation or dismissal; as well as the participation of the different local sectors in promoting the to their respective saints will be presented. This analysis will take into consideration the conflictive relationship between Spanish settlers and native people in Yucatán, a situation that prevented the using of aboriginal cultural elements in the shaping of a new identity

    Este trabajo estudia los problemas que acompañaron la gestación de una identidad propia y común para los residentes hispanos de la villa y puerto de San Francisco de Campeche durante el período colonial y la participación de elementos religiosos, particularmente el culto a los santos patronos, en el proceso. Teniendo como telón de fondo la peculiaridad de la región yucateca, donde una conflictiva relación entre españoles e indígenas impidió la utilización de elementos culturales prehispánicos en la formación de una conciencia identitaria, se analizan diversos factores, como las características de los santos tutelares de los barrios y de algunas corporaciones locales, los procesos de adopción, adaptación u olvido de sus cultos por parte del vecindario porteño y la participación de los diferentes sectores locales en la promoción de sus santos patronos.

  5. INSTITUIÇÃO E INDIVÍDUO NA REFORMA ECLESIAL DE LUTERO E DE FRANCISCO

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    Mário de França Miranda

    2017-01-01

    Full Text Available RESUMO: O texto busca confrontar a reforma de Lutero com a de Francisco na perspectiva da relação entre instituição eclesial e indivíduo cristão. Em sua primeira parte aborda a necessária conexão e interdependência do contexto histórico e a vivência pessoal da fé cristã, nem sempre devidamente correta ao longo da história do cristianismo. Em seguida vem tratada a reforma de Lutero: a decadente situação eclesial de seu tempo e sua luta pela liberdade do cristão, por um relacionamento pessoal com Deus na fé. A parte seguinte estuda, sob o mesmo prisma, a reforma eclesial do papa Francisco que propugna mudanças nas mentalidades e nas estruturas eclesiais em prol de um maior respeito à pessoa humana sempre acolhida por Deus misericordioso. Finalmente se alude brevemente a uma possível dimensão ecumênica da reforma em seus 500 anos. ABSTRACT: The text seeks to confront both Luther’s and Francis’ Reform in the perspective of relationship between ecclesial institution and the Christian individual. The first part takes on the necessary connection and inter-dependency of the historical context and the personal experience of Christian faith, not always evident throughout Christianity’s history. This is followed by Luther’s Reform: how the ecclesial situation decayed in his time and his fight for both Christian freedom and his personal relationship with God. The next part studies, under the same perspective, Pope Francis’ ecclesial reform, which calls for changes in both mindsets and ecclesial structures in favor of the human person with greater respect and a constant embrace from a merciful God. Finally, the text mentions, succinctly, the Reform’s possible ecumenical dimension over its 500 years.

  6. [Congenital defects and exposure to pesticides in São Francisco Valley].

    Science.gov (United States)

    Silva, Silvio Romero Gonçalves E; Martins, José Luiz; Seixas, Simone; Silva, Daniela Conceição Gomes da; Lemos, Sidney Pereira Pinto; Lemos, Patrícia Veruska Barbosa

    2011-01-01

    to evaluate associations between parental exposure to pesticides and births with congenital defects in São Francisco Valley, as well as the demographic profile and the defects found. in this case-control study, each case (newborns with congenital defects) had two controls (healthy newborns). The subjects were born in the city of Petrolina, in São Francisco Valley, in 2009. The sample consisted of 42 cases and 84 controls. Data were gathered by a structured questionnaire adapted from Latin-American Collaborative Study of Congenital Malformations (ECLAMC), with the addition of questions related to exposure to pesticides, analysis of the medical records and contact with the hospital's pediatrician. The χ2 test was performed with a significance level of 5% to identify the variables with the greatest differences between case and control groups. Odds Ratio (OR) for the sample was calculated, as well as the OR obtained by logistic regression analysis, and finally, multivariate logistic regression analysis was performed. there was a greater exposure to pesticides during pregnancy in infants with congenital defects compared to healthy subjects. Increased risk was observed when at least one parent was exposed to pesticides (adjusted OR = 1.3; 95%CI = 0.4 - 3.9). The sociodemographic variables associated with congenital defects were: low school level, low weight, prematurity, young parents, chronic diseases, and physical factors. Multiple malformations and defects of the musculoskeletal and nervous systems were more frequently found. the present study suggests an association between exposure to pesticides and the occurrence of congenital defects, although the data were not significant.

  7. Pedro de Valencia, Francisco de Gurmendi and the Plomos de Granada

    Directory of Open Access Journals (Sweden)

    Magnier, Grace

    2003-12-01

    Full Text Available The Inquisition in 1618 seized all the papers of Pedro de Valencia, renowned humanist, biblical scholar and chronicler of Philip III. The papers of other members of his circle were also confiscated. In this article I examine the two most important texts: Sobre el pergamino y láminas de Granada of Valencia and a Libelo Segundo of Francisco de Gurmendi, interpreter of Oriental languages for Philip III. The article is structured around Gurmendi's response to a memorial published in 1617 by Archbishop Pedro de Castro in defence of one of his translators. Gurmendi, working from his translation of the first two Lead Books, shows how these contain heretical ideas on the Trinity and how the memorialista has mistranslated many passages.

    En 1618 la Inquisición confiscó todos los papeles de Pedro de Valencia, humanista insigne, exegeta bíblico y cronista del reino y de las Indias de Felipe III. También confiscó los papeles de otros miembros de su círculo. En este artículo examino los dos textos más importantes: Sobre el pergamino y láminas de Granada de Valencia y un Libelo segundo de Francisco de Gurmendi, intérprete en lenguas orientales del rey. El artículo se centra en la respuesta de Gurmendi a un memorial del Arzobispo Pedro de Castro en el que se defiende a uno de sus traductores. Partiendo de su traducción de los dos primeros libros plúmbeos, Gurmendi muestra las herejías trinitarias que éstos contienen y cómo el memorialista ha traducido mal muchos pasajes.

  8. What Determines Water Temperature Dynamics in the San Francisco Bay-Delta System?

    Science.gov (United States)

    Vroom, J.; van der Wegen, M.; Martyr-Koller, R. C.; Lucas, L. V.

    2017-11-01

    Water temperature is an important factor determining estuarine species habitat conditions. Water temperature is mainly governed by advection (e.g., from rivers) and atmospheric exchange processes varying strongly over time (day-night, seasonally) and the spatial domain. On a long time scale, climate change will impact water temperature in estuarine systems due to changes in river flow regimes, air temperature, and sea level rise. To determine which factors govern estuarine water temperature and its sensitivity to changes in its forcing, we developed a process-based numerical model (Delft3D Flexible Mesh) and applied it to a well-monitored estuarine system (the San Francisco Estuary) for validation. The process-based approach allows for detailed process description and a physics-based analysis of governing processes. The model was calibrated for water year 2011 and incorporated 3-D hydrodynamics, salinity intrusion, water temperature dynamics, and atmospheric coupling. Results show significant skill in reproducing temperature observations on daily, seasonal, and yearly time scales. In North San Francisco Bay, thermal stratification is present, enhanced by salinity stratification. The temperature of the upstream, fresh water Delta area is captured well in 2-D mode, although locally—on a small scale—vertical processes (e.g., stratification) may be important. The impact of upstream river temperature and discharge and atmospheric forcing on water temperatures differs throughout the Delta, possibly depending on dispersion and residence times. Our modeling effort provides a sound basis for future modeling studies including climate change impact on water temperature and associated ecological modeling, e.g., clam and fish habitat and phytoplankton dynamics.

  9. Linking Hydrodynamic Complexity to Delta Smelt (Hypomesus transpacificus Distribution in the San Francisco Estuary, USA

    Directory of Open Access Journals (Sweden)

    Aaron J. Bever

    2016-03-01

    Full Text Available doi: http://dx.doi.org/10.15447/sfews.2016v14iss1art3Long-term fish sampling data from the San Francisco Estuary were combined with detailed three-dimensional hydrodynamic modeling to investigate the relationship between historical fish catch and hydrodynamic complexity. Delta Smelt catch data at 45 stations from the Fall Midwater Trawl (FMWT survey in the vicinity of Suisun Bay were used to develop a quantitative catch-based station index. This index was used to rank stations based on historical Delta Smelt catch. The correlations between historical Delta Smelt catch and 35 quantitative metrics of environmental complexity were evaluated at each station. Eight metrics of environmental conditions were derived from FMWT data and 27 metrics were derived from model predictions at each FMWT station. To relate the station index to conceptual models of Delta Smelt habitat, the metrics were used to predict the station ranking based on the quantified environmental conditions. Salinity, current speed, and turbidity metrics were used to predict the relative ranking of each station for Delta Smelt catch. Including a measure of the current speed at each station improved predictions of the historical ranking for Delta Smelt catch relative to similar predictions made using only salinity and turbidity. Current speed was also found to be a better predictor of historical Delta Smelt catch than water depth. The quantitative approach developed using the FMWT data was validated using the Delta Smelt catch data from the San Francisco Bay Study. Complexity metrics in Suisun Bay were evaluated during 2010 and 2011. This analysis indicated that a key to historical Delta Smelt catch is the overlap of low salinity, low maximum velocity, and low Secchi depth regions. This overlap occurred in Suisun Bay during 2011, and may have contributed to higher Delta Smelt abundance in 2011 than in 2010 when the favorable ranges of the metrics did not overlap in Suisun Bay.

  10. Francisco Antonio Zea: periodista, botánico y político

    Directory of Open Access Journals (Sweden)

    Soto Arango, Diana E.

    1996-06-01

    Full Text Available This work analyzes the journalistic facet of Francisco Antonio Zea, whose first article, «Avisos de Hebephilo», was published in 1791 in the Papel Periódico de la ciudad de Santa Fé de Bogotá. His interest for the press shows at his stage of student in the National Institute of France, but won't be up to 1803, at his return to Madrid, when he proves his talent for the organization and journalistic administration on The Mercury and on the Gazette de Madrid. Later on, being manager of the Royal Botanical Garden of Madrid, he shares the management of the Semanario de Agricultura y Artes, and, finally, in 1818 establishes and directs the Venezuelan Correo del Orinoco.

    Este trabajo analiza la faceta periodística de Francisco Antonio Zea, cuyo primer artículo, «Avisos de Hebephilo», se publicó en 1791 en el Papel Periódico de la ciudad de Santa Fé de Bogota. Su interés por la prensa se manifiesta en su etapa de estudiante en el Instituto Nacional de Francia, pero no será hasta 1803, a su regreso a Madrid, cuando evidencie sus dotes para la organización y dirección periodísticas en El Mercurio y en la Gaceta de Madrid. Posteriormente, siendo director del Real Jardín Botánico de Madrid, comparte la dirección del Semanario de Agricultura y Artes, y, finalmente, en 1818 funda y dirige el venezolano Correo del Orinoco.

  11. Improved Storm Monitoring and Prediction for the San Francisco Bay Area

    Science.gov (United States)

    Cifelli, R.; Chandrasekar, V.; Anderson, M.; Davis, G.

    2017-12-01

    The Advanced Quantitative Precipitation Information (AQPI) System is a multi-faceted project to improve precipitation and hydrologic monitoring, prediction, and decision support for the San Francisco Bay Area. The Bay Area faces a multitude of threats from extreme events, including disrupted transportation from flooded roads and railroad lines, water management challenges related to storm water, river and reservoir management and storm-related damage demanding emergency response. The threats occur on spatial scales ranging from local communities to the entire region and time scales ranging from hours to days. These challenges will be exacerbated by future sea level rise, more extreme weather events and increased vulnerabilities. AQPI is a collaboration of federal, state and local governments with assistance from the research community. Led by NOAA's Earth System Research Laboratory, in partnership with the Cooperative Institute for Research in the Atmosphere, USGS, and Scripps, AQPI is a four-year effort funded in part by a grant from the California Department of Water Resource's Integrated Regional Water Management Program. The Sonoma County Water Agency is serving as the local sponsor of the project. Other local participants include the Santa Clara Valley Water District, San Francisco Public Utilities Commission, and the Bay Area Flood Protection Agencies Association. AQPI will provide both improved observing capabilities and a suite of numerical forecast models to produce accurate and timely information for benefit of flood management, emergency response, water quality, ecosystem services, water supply and transportation management for the Bay Area. The resulting information will support decision making to mitigate flood risks, secure water supplies, minimize water quality impacts to the Bay from combined sewer overflows, and have improved lead-time on coastal and Bay inundation from extreme storms like Atmospheric Rivers (ARs). The project is expected to

  12. An Introduction to the San Francisco Estuary Tidal Wetlands Restoration Series

    Directory of Open Access Journals (Sweden)

    Larry R. Brown

    2003-10-01

    Full Text Available Restoration of tidal wetlands may provide an important tool for improving ecological health and water management for beneficial uses of the San Francisco Estuary (hereafter “Estuary”. Given the large losses of tidal wetlands from San Francisco Bay and the Sacramento-San Joaquin Delta in the last 150 years, it seems logical to assume that restoring tidal wetlands will have benefits for a variety of aquatic and terrestrial native species that have declined during the same time period. However, many other changes have also occurred in the Estuary concurrent with the declines of native species. Other factors that might be important in species declines include the effects of construction of upstream dams, large and small water diversions within the Sacramento-San Joaquin Delta, agricultural pesticides, trace elements from industrial and agricultural activities, and invasions of alien species. Discussions among researchers, managers, and stakeholders have identified a number of uncertainties regarding the potential benefits of tidal wetland restoration. The articles of the Tidal Wetlands Restoration Series address four major issues of concern. Stated as questions, these are: 1. Will tidal wetland restoration enhance populations of native fishes? 2. Will wetland restoration increase rates of methylation of mercury? 3. Will primary production and other ecological processes in restored tidal wetlands result in net export of organic carbon to adjacent habitats, resulting in enhancement of the food web? Will the carbon produced contribute to the formation of disinfection byproducts when disinfected for use as drinking water? 4. Will restored tidal wetlands provide long-term ecosystem benefits that can be sustained in response to ongoing physical processes, including sedimentation and hydrodynamics? Reducing the uncertainty surrounding these issues is of critical importance because tidal wetland restoration is assumed to be a critical tool for

  13. Calibration of Optical Back Scatterance for Suspended Sediment Concentration With San Francisco Bay Sediment

    Science.gov (United States)

    Keller, B.

    2005-12-01

    Optical back scatterance (OBS) is used by USGS to indirectly quantify suspended sediment concentration in the waters of San Francisco Bay. The use of one of the types of OBS instruments that is used in the Bay was evaluated for quantification of discharge water from sand yards, where dredged bay floor sand is brought on land for commercial purposes. The instrument response was calibrated with synthetic samples prepared from settled, previously suspended fine sediment, collected on various dates and derived from the same general area of central San Francisco Bay. The sediment samples were washed with fresh water, oven dried, sieved, and mixed into water in a test chamber. The responses of various sediment samples were compared with that of silica flour, a commercially available industrial material with similar particle size and density, that is white in color. Multiple tests with sediment samples from individual dates yielded extremely repeatable, almost linear instrument responses as a function of varying concentration. Sediment samples from different dates yielded varying responses, ranging from 2.0 to 2.8 times the response of silica flour. This response difference, a factor of approximately 1.4, is interpreted to be due to small differences in the darkness ("color") of the sediment samples. In a comparison with an EPA test method that uses filtration and weighing, performed at commercial laboratories, the "total suspended solids" (TSS, used synonymously with the term "suspended sediment concentration") analyses of the mixed synthetic sample waters yielded very poor results. Saline water samples were often associated with TSS test results that were higher than the known synthetic sample concentrations, indicating that the lab tests were often measuring dissolved salt rather than suspended sediment.

  14. Application of INAA to provenance study of ceramics from Baixo Sao Francisco River, Sergipe, Brazil

    International Nuclear Information System (INIS)

    Santos, J.O.; Munita, C.S.; Toyota, Rosimeiri G.; Vergne, C.

    2007-01-01

    The study of the physical and chemical characteristics of crafts, in association with historical and archaeological research, has allowed for the reconstruction of ancient community habits. Archaeological studies include several techniques to reconstruct ancient cultures. Since ceramics represent a sophisticated merging of previously separate domains of human knowledge and experience, these objects are studied by means of archaeometric methods. In recent years an interdisciplinary research program was started between Museu Arqueologico de Xingo (MAX) and Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP) to study the ancient ceramist cultures from Xingo region, located in Sergipe, Brazilian Northeast. Recent studies conducted in the area have showed the existence of an independent ceramist group without relation to the ceramist group well established in the Brazilian Northeast, Tupiguarani and Aratu. Instrumental neutron activation analysis, INAA, is a suitable technique for provenance studies. In this work the chemical composition of 103 samples: 30 clays and 73 ceramics from Barracao archaeological site, from Baixo Sao Francisco, were analyzed. This analysis allowed for the definition of compositional groups of ceramics according to the chemical similarities of ceramic paste, which reveals the raw material composition used in the manufacturing process by prehistoric man. The outliers were identified by means robust Mahalanobis distance. The results were interpreted by means of cluster analysis, principal components analysis and discriminant analysis. The results obtained in this work, in association with archaeological information, allowed for the identification of the ceramic groups in relation to the ceramist occupations of the Xingo area. This work contributes for the reconstruction of the Baixo Sao Francisco region communities and for the reconstitution of the Brazilian Northeast ceramist population. (author)

  15. State of transition: Marijuana use among young adults in the San Francisco Bay Area.

    Science.gov (United States)

    Holmes, Louisa M; Popova, Lucy; Ling, Pamela M

    2016-09-01

    California may vote on marijuana legalization in 2016. Young adults have the highest rates of marijuana use, but little is known about the correlates of use in this age group, including factors that may be affected by policy change. We investigated whether there are differences in marijuana use by sociodemographic characteristics, psychological distress, loneliness and social support, controlling for risk factors such as alcohol and cigarette use as well as perceived harm of marijuana. Bivariate and multivariable analysis of past 30day marijuana use using the 2014 San Francisco Bay Area Young Adult Health Survey, a probabilistic multi-mode survey of (N=1324) young adults (aged 18-26years) residing in Alameda and San Francisco Counties, stratified by race/ethnicity. 291 (27%) sample participants reported current marijuana use. Compared to non-Hispanic Whites (referent) Asian/Pacific Islander respondents were less likely to use marijuana (AOR, 0.42; 95% CI, 0.22-0.80) while multiracial participants were twice as likely (AOR, 2.27; 95% CI, 1.06-4.85). Psychological distress was not related to marijuana use, but social support (AOR, 1.42; 95% CI, 1.08-1.88) and loneliness (AOR, 1.42; 95% CI, 1.09-1.86) were. Perceived harm of marijuana was inversely related to marijuana use (AOR, 0.60; 95% CI, 0.51-0.70), while smoking cigarettes (AOR, 3.95; 95% CI, 2.28-6.84) and binge drinking (AOR, 1.13; 95% CI, 1.03-1.24) were positively related. Legalization policies should include public education campaigns addressing potential harms of marijuana use particularly targeting multiracial young adults who also engage in other risk behaviors, such as cigarette smoking and binge drinking. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Polychlorinated biphenyls in the exterior caulk of San Francisco Bay Area buildings, California, USA.

    Science.gov (United States)

    Klosterhaus, Susan; McKee, Lester J; Yee, Donald; Kass, Jamie M; Wong, Adam

    2014-05-01

    Extensive evidence of the adverse impacts of polychlorinated biphenyls (PCBs) to wildlife, domestic animals, and humans has now been documented for over 40 years. Despite the ban on production and new use of PCBs in the United States in 1979, a number of fish consumption advisories remain in effect, and there remains considerable uncertainty regarding ongoing environmental sources and management alternatives. Using a blind sampling approach, 25 caulk samples were collected from the exterior of ten buildings in the San Francisco Bay Area and analyzed for PCBs using congener-specific gas chromatography-mass spectrometry (GC-MS) and chlorine using portable X-ray fluorescence (XRF). PCBs were detected in 88% of the caulk samples collected from the study area buildings, with 40% exceeding 50 ppm. Detectable PCB concentrations ranged from 1 to 220,000 ppm. These data are consistent with previous studies in other cities that have identified relatively high concentrations of PCBs in concrete and masonry buildings built between 1950 and 1980. Portable XRF was not a good predictor of the PCB content in caulk and the results indicate that portable XRF analysis may only be useful for identifying caulk that contains low concentrations of Cl (≤ 10,000 ppm) and by extension low or no PCBs. A geographic information system-based approach was used to estimate that 10,500 kg of PCBs remain in interior and exterior caulk in buildings located in the study area, which equates to an average of 4.7 kg PCBs per building. The presence of high concentrations in the exterior caulk of currently standing buildings suggests that building caulk may be an ongoing source of PCBs to the San Francisco Bay Area environment. Further studies to expand the currently small international dataset on PCBs in caulking materials in buildings of countries that produced or imported PCBs appear justified in the context of both human health and possible ongoing environmental release. Copyright © 2014 Elsevier

  17. The earthquake cycle in the San Francisco Bay region: A.D. 1600–2012

    Science.gov (United States)

    Schwartz, David P.; Lienkaemper, James J.; Hecker, Suzanne; Kelson, Keith I.; Fumal, Thomas E.; Baldwin, John N.; Seitz, Gordon G.; Niemi, Tina

    2014-01-01

    Stress changes produced by the 1906 San Francisco earthquake had a profound effect on the seismicity of the San Francisco Bay region (SFBR), dramatically reducing it in the twentieth century. Whether the SFBR is still within or has emerged from this seismic quiescence is an issue of debate with implications for earthquake mechanics and seismic hazards. Historically, the SFBR has not experienced one complete earthquake cycle (i.e., the accumulation of stress, its release primarily as coseismic slip during surface‐faulting earthquakes, its re‐accumulation in the interval following, and its subsequent rerelease). The historical record of earthquake occurrence in the SFBR appears to be complete at about M 5.5 back to 1850 (Bakun, 1999). For large events, the record may be complete back to 1776, which represents about half a cycle. Paleoseismic data provide a more complete view of the most recent pre‐1906 SFBR earthquake cycle, extending it back to about 1600. Using these, we have developed estimates of magnitude and seismic moment for alternative sequences of surface‐faulting paleoearthquakes occurring between 1600 and 1776 on the region’s major faults. From these we calculate seismic moment and moment release rates for different time intervals between 1600 and 2012. These show the variability in moment release and suggest that, in the SFBR regional plate boundary, stress can be released on a single fault in great earthquakes such as that in 1906 and in multiple ruptures distributed on the regional plate boundary fault system on a decadal time scale.

  18. Seismic velocities and geologic logs from boreholes at three downhole arrays in San Francisco, California

    Science.gov (United States)

    Gibbs, James F.; Fumal, Thomas E.; Borcherdt, Roger D.; Warrick, Richard E.; Liu, Hsi-Ping; Westerlund, Robert E.

    1994-01-01

    The Loma Prieta earthquake of October 17, 1989 (1704 PST), has reinforced observations made by Wood and others (1908) after the 1906 San Francisco earthquake, that poor ground conditions (soft soil) increase the likelihood of shaking damage to structures. Since 1908 many studies (for example Borcherdt, 1970, Borcherdt and Gibbs, 1976, Borcherdt and Glassmoyer, 1992) have shown that soft soils amplify seismic waves at frequencies that can be damaging to structures. Damage in the City of San Francisco from the Loma Prieta earthquake was concentrated in the Marina District, the Embarcadero, and the China Basin areas. Each of these areas, to some degree, is underlain by soft soil deposits. These concentrations of damage raise important questions regarding the amplification effects of such deposits at damaging levels of motion. Unfortunately, no strong-motion recordings were obtained in these areas during the Loma Prieta earthquake and only a limited number (< 10) have been obtained on other soft soil sites in the United States. Consequently, important questions exist regarding the response of such deposits during damaging earthquakes, especially questions regarding the nonlinear soil response. Towards developing a data set to address these important questions, borehole strong-motion arrays have been installed at three locations. These arrays consist of groups of wide-dynamic-range pore-pressure transducers and three-component accelerometers, the outputs of which are recorded digitally. The arrays are designed to provide an integrated set of data on ground shaking, liquifaction-induced ground failure, and structural response. This report describes the detailed geologic, seismic, and material-property determinations derived at each of these sites.

  19. Prevalence and origin of De Novo duplications in Charcot-Marie-Tooth disease type 1A: First report of a De Novo duplication with a maternal origin

    Energy Technology Data Exchange (ETDEWEB)

    Blair, I.P.; Nash, J.; Gordon, M.J.; Nicholson, G.A. [Univ. of Sydney, New South Wales (United Kingdom)

    1996-03-01

    Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy. Sporadic cases of CMT have been described since the earliest reports of the disease. The most frequent form of the disorder, CMT1A, is associated with a 1.5-Mb DNA duplication on chromosome 17p11.2, which segregates with the disease. In order to investigate the prevalence of de novo CMT1A duplications, this study examined 118 duplication-positive CMT1A families. In 10 of these families it was demonstrated that the disease had arisen as the result of a de novo mutation. By taking into account the ascertainment of families, it can be estimated that {>=}10% of autosomal dominant CMT1 families are due to de novo duplications. The CMT1A duplication is thought to be the product of unequal crossing over between parental chromosome 17 homologues during meiosis. Polymorphic markers from within the duplicated region were used to determine the parental origin of these de novo duplications in eight informative families. Seven were of paternal and one of maternal origin. This study represents the first report of a de novo duplication with a maternal origin and indicates that it is not a phenomenon associated solely with male meioses. Recombination fractions for the region duplicated in CMT1A are larger in females than in males. That suggests that oogenesis may be afforded greater protection from misalignment during synapsis, and/or that there may be lower activity of those factors or mechanisms that lead to unequal crossing over at the CMT1A locus. 41 refs., 2 figs.

  20. Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening.

    Science.gov (United States)

    Niyomrattanakit, Pornwaratt; Wan, Kah Fei; Chung, Ka Yan; Abas, Siti Nurdiana; Seh, Cheah Chen; Dong, Hongping; Lim, Chin Chin; Chao, Alexander Theodore; Lee, Chang Bok; Nilar, Shahul; Lescar, Julien; Shi, Pei-Yong; Beer, David; Lim, Siew Pheng

    2015-07-01

    Dengue virus (DENV) NS5 protein comprises an N-terminal methyltransferase domain and a C-terminal RNA-dependent RNA polymerase domain (RdRp). DENV RdRp is responsible for viral RNA synthesis via a de novo initiation mechanism and represents an attractive target for anti-viral therapy. Herein we describe the characterization of its de novo initiation activities by PAGE analyses and the knowledge gained was used to develop a fluorescent-based assay. A highly processive and robust assay was achieved by addition of cysteine in the assay buffer. This stabilized the apo-enzyme, and rendered optimal de novo initiation activity while balancing its intrinsic terminal transferase activity. Steady-state kinetic parameters of the NTP and RNA substrates under these optimal conditions were determined for DENV1-4 FL NS5. Heavy metal ions such as Zn(++) and Co(++) as well as high levels of monovalent salts, suppressed DENV polymerase de novo initiation activities. This assay was validated with nucleotide chain terminators and used to screen two diverse small library sets. The screen data obtained was further compared with concurrent screens performed with a DENV polymerase elongation fluorescent assay utilizing pre-complexed enzyme-RNA. A higher hit-rate was obtained for the de novo initiation assay compared to the elongation assay (∼2% versus ∼0.1%). All the hits from the latter assay are also identified in the de novo initiation assay, indicating that the de novo initiation assay performed with the stabilized apo-enzyme has the advantage of providing additional chemical starting entities for inhibiting this enzyme. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Coccidioidomicose: novo caso brasileiro Coccidiodomycosis: a new Brazilian case

    Directory of Open Access Journals (Sweden)

    Mário A.P. Moraes

    1998-12-01

    Full Text Available É descrito um caso de coccidioidomicose pulmonar oriundo da zona rural de Bertolínia, PI. A manifestação clínica principal consistiu em dor torácica e o diagnóstico teve por base o achado do agente3/4Coccidioides immitis3/4em cortes histológicos. Formas teciduais do microrganismo3/4esférulas imaturas e maduras3/4estavam presentes nas lesões observadas em fragmento pulmonar removido do paciente por biópsia a céu aberto. Este novo caso autóctone da doença, como os outros anteriormente descritos no Brasil, procedia do interior semi-árido da Região Nordeste. O ambiente quente e seco do sertão nordestino oferece, sem dúvida, condições propícias ao desenvolvimento de C. immitis, um habitante do solo. As pessoas e animais do local devem adquirir a infecção ao revolver a terra, ato que os expõe à poeira contendo os propágulos do fungo.A case of pulmonary coccidioidomycosis from the rural zone of Bertolinia, PI, is reported. The patient, a farm worker, attributed his illness to the dust inhaled while digging a water well during the dry season of the year, some weeks before the onset of the clinical manifestations. The main symptoms of the disease were severe chest pain and moderate fever. The diagnosis was made histopathologically: tissue phase fungal organisms3/4immature spherules and spherules with endospores3/4were observed in histological sections of a lung fragment obtained by open chest biopsy. This is the twelfth autochthonous case of coccidioidomycosis found so far in Brazil. All of them involved native inhabitants of the semi-arid part of Northeastern Brazil. The hot and dry environment of the region seems to favor the development of C. immitis in the soil. Humans and animals probably acquire the infection by digging the soil, when they become exposed to the conidium-bearing dust raised by this activity.

  2. Suppression of polygalacturonase gene expression in the phytopathogenic fungus Ophiostoma novo-ulmi by RNA interference.

    Science.gov (United States)

    Carneiro, Joyce S; de la Bastide, Paul Y; Chabot, Meghan; Lerch, Lindsey; Hintz, William E

    2010-05-01

    The fungal pathogen, Ophiostomo novo-ulmi, has been responsible for the rapid decline of American elm (Ulmus americana) across North America and remains a serious threat to surviving elm populations. The production of pectinolytic polygalacturonase enzymes has been implicated as a virulence factor for many fungal pathogens, including O. novo-ulmi. Previous work has shown that the targeted disruption of the endopolygalacturonase gene locus epg1 of O. novo-ulmi reduced, but did not eliminate pectinase activity. In the present study, we evaluated the use of RNA interference (RNAi) as a method of suppressing expression of the epg1 locus in O. novo-ulmi and compared its efficiency to the gene disruption method. While there was a reduction in epg1-specific mRNA transcripts and in the amount of polygalacturonase enzyme secreted for both methods of gene regulation, neither method completely suppressed the expression of pectinase activity. There was, however, a significantly greater reduction in both transcript levels and secreted enzyme observed for some of the RNAi transformants. As the first demonstration of RNAi in O. novo-ulmi, this method of gene regulation shows promise in future studies of gene expression and pathogenicity. Copyright 2010 Elsevier Inc. All rights reserved.

  3. High frequencies of de novo CNVs in bipolar disorder and schizophrenia.

    LENUS (Irish Health Repository)

    Malhotra, Dheeraj

    2011-12-22

    While it is known that rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear. Here, we reasoned that a contribution of CNVs to mood disorders might be most evident for de novo mutations. We performed a genome-wide analysis of de novo CNVs in a cohort of 788 trios. Diagnoses of offspring included bipolar disorder (n = 185), schizophrenia (n = 177), and healthy controls (n = 426). Frequencies of de novo CNVs were significantly higher in bipolar disorder as compared with controls (OR = 4.8 [1.4,16.0], p = 0.009). De novo CNVs were particularly enriched among cases with an age at onset younger than 18 (OR = 6.3 [1.7,22.6], p = 0.006). We also confirmed a significant enrichment of de novo CNVs in schizophrenia (OR = 5.0 [1.5,16.8], p = 0.007). Our results suggest that rare spontaneous mutations are an important contributor to risk for bipolar disorder and other major neuropsychiatric diseases.

  4. Plasma levels of immunoinflammatory markers in De Novo coronary atherosclerosis and coronary restenosis postangioplasty

    Directory of Open Access Journals (Sweden)

    Alexandre Schaan de Quadros

    2001-05-01

    Full Text Available OBJECTIVE: To compare circulating plasma levels of immunoinflammatory markers in patients with known de novo coronary artery disease and patients with postangioplasty restenosis. METHODS: Using enzymatic immunoabsorbent assay, we measured plasma levels of soluble interleukin-2 receptosr, tumor necrosis factor alpha, and soluble tumor necrosis alpha receptors I and II in 11 patients with restenosis postcoronary angioplasty (restenosis group, in 10 patients with primary atherosclerosis (de novo group who were referred for coronary angiography because of stable or unstable angina, and in 9 healthy volunteers (control group. Levels of soluble interleukin-2 receptors were significantly higher in the de novo group compared with that in the restenosis and control groups. Levels were also higher in the restenosis group compared with that in the control group. Plasma levels of tumor necrosis alpha and receptor levels were significantly higher in the de novo group compared to with that in the restenosis and control groups, but levels in the restenosis group were not different from that in the controls. CONCLUSION: Coronary artery disease, either primary or secondary to restenosis, is associated with significant immunoinflammatory activity, which can be assessed by examining the extent of circulating plasma levels of inflammatory markers. Moreover, patients with de novo lesions appear to have increased inflammatory activity compared with patients with restenosis.

  5. Empirical evidence for synchrony in the evolution of TB cases and HIV+ contacts among the San Francisco homeless.

    Directory of Open Access Journals (Sweden)

    Mojdeh Mohtashemi

    Full Text Available The re-emergence of tuberculosis (TB in the mid-1980s in many parts of the world, including the United States, is often attributed to the emergence and rapid spread of human immunodeficiency virus (HIV and acquired immunodeficiency syndrome (AIDS. Although it is well established that TB transmission is particularly amplified in populations with high HIV prevalence, the epidemiology of interaction between TB and HIV is not well understood. This is partly due to the scarcity of HIV-related data, a consequence of the voluntary nature of HIV status reporting and testing, and partly due to current practices of screening high risk populations through separate surveillance programs for HIV and TB. The San Francisco Department of Public Health, TB Control Program, has been conducting active surveillance among the San Francisco high-risk populations since the early 1990s. We present extensive TB surveillance data on HIV and TB infection among the San Francisco homeless to investigate the association between the TB cases and their HIV+ contacts. We applied wavelet coherence and phase analyses to the TB surveillance data from January 1993 through December 2005, to establish and quantify statistical association and synchrony in the highly non-stationary and ostensibly non-periodic waves of TB cases and their HIV+ contacts in San Francisco. When stratified by homelessness, we found that the evolution of TB cases and their HIV+ contacts is highly coherent over time and locked in phase at a specific periodic scale among the San Francisco homeless, but no significant association was observed for the non-homeless. This study confirms the hypothesis that the dynamics of HIV and TB are significantly intertwined and that HIV is likely a key factor in the sustenance of TB transmission among the San Francisco homeless. The findings of this study underscore the importance of contact tracing in detection of HIV+ individuals that may otherwise remain undetected, and

  6. Zooplankton data collected using net casts from the FRANCISCO DE ULLOA in the North Pacific Ocean from 01 January 1999 to 31 January 1999 (NODC Accession 0000912)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Zooplankton data were collected using net casts in the North Pacific Ocean from FRANCISCO DE ULLOA. Data were collected from 01 January 1999 to 31 January 1999. Data...

  7. Plankton data collected using net casts from the FRANCISCO DE ULLOA in the North Pacific Ocean from 15 July 1998 to 30 July 1998 (NODC Accession 0000911)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Plankton data were collected using net casts in the North Pacific Ocean from FRANCISCO DE ULLOA. Data were collected from 15 July 1998 to 30 July 1998. Data were...

  8. PCDD/F, PCB, HXCBZ, PAH, AND PM EMISSION FACTORS FOR FIREPLACE AND WOODSTOVE COMBUSTION IN THE SAN FRANCISCO BAY REGION

    Science.gov (United States)

    Emissions from residential fireplace and woodstove appliances burning fuels available from the San Francisco Bay area were sampled for polychlornated dibenzodioxins and dibenzofurans (PCDDs/Fs), polychlorinated biphenyls (PCBs), hexachlorobenzene (HxCBz), particulatematter (P...

  9. EX1006 Hawaii to San Francisco Transit to Drydock (EX1006, EM302) on Okeanos Explorer in Hawaii, US West Coast

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Okeanos Explorer (EX) will transit from Honolulu, HI to San Francisco for the winter inport and drydock period. During the transit, the EX will perform 24-hour...

  10. University of California San Francisco (UCSF-2): Expression Analysis of Superior Cervical Ganglion from Backcrossed TH-MYCN Transgenic Mice | Office of Cancer Genomics

    Science.gov (United States)

    The CTD2 Center at University of California San Francisco (UCSF-2) used genetic analysis of the peripheral sympathetic nervous system to identify potential therapeutic targets in neuroblastoma. Read the abstract Experimental Approaches Read the detailed Experimental Approaches

  11. ESCARABAJOS TIGRE (COLEOPTERA: CICINDELIDAE DEL MUSEO ENTOMOLÓGICO FRANCISCO LUÍS GALLEGO: NUEVOS REGISTROS PARA DEPARTAMENTOS DE COLOMBIA TIGER BEETLES (COLEOPTERA: CICINDELIDAE AT THE ENTOMOLOGICAL MUSEUM FRANCISCO LUÍS GALLEGO: NEW RECORDS

    Directory of Open Access Journals (Sweden)

    Manuel Alejandro Ramírez Mora

    2008-06-01

    Full Text Available Se registran por primera vez las especies de escarabajos tigre (Coleoptera: Cicindelidae presentes en el Museo Entomológico Francisco Luis Gallego (MEFLG. Se identificaron 167 especimenes distribuidos en ocho géneros y 27 especies, se reportan 24 nuevos registros para diferentes departamentos de Colombia. Se señalan aspectos importantes de la taxonomía y sistemática del grupo. Además, se presentan comentarios biológicos y de distribución de las especies.Tiger beetles (Coleoptera: Cicindelidae species at the Museo Entomológico Francisco Luis Gallego (MEFLG are registered by first time. 167 specimens in 8 genus and 27 species were identified, 24 new records for different Colombian states are reported. Some important aspects of the group’s taxonomy and systematic are pointed. Additionally, species’ biological and distributional comments are presented.

  12. A novel A2 allele found in Leishmania (Leishmania infantum chagasi Novo alelo do gene A2 descrito em Leishmania (Leishmania infantum chagasi

    Directory of Open Access Journals (Sweden)

    Trícia Maria Ferreira de Sousa Oliveira

    2011-03-01

    por todo o país. Muitas manifestações clínicas relacionadas à infecção por Leishmania estão ligadas à relação parasito-hospedeiro, e vários possíveis fatores de virulência dos parasitas, que causam a LV, são alvos de estudo, tais como os genes A2. O gene A2 foi isolado pela primeira vez em 1994 e, em seguida, em 2005, três novos alelos foram descritos em Leishmania (Leishmania infantum. No presente estudo, um fragmento do gene A2 de uma população clonal de L.(L. infantum chagasi foi amplificado por PCR e sua sequência de nucleotídeos determinada. O fragmento mostrou 90% de similaridade com alelos do gene A2 de Leishmania (Leishmania donovani e de L. (L. infantum, descritos na literatura. Entretanto, a tradução da sequência de nucleotídeos mostra diferenças na sequência de aminoácidos da proteína, que podem ser essenciais em determinar a variabilidade do gene A2 em espécies do complexo L. (L. donovani e representa uma ferramenta adicional na compreenssão do papel dessa família de genes na virulência e imunidade da leishmaniose visceral. O conhecimento dessa variação é importante para o desenvolvimento de testes diagnósticos mais precisos e ferramentas mais eficazes no controle da doença.

  13. Museum under seven hills. New building of the Academy of Science at San Francisco/USA by Renzo Piano; Museum unter sieben Huegeln. Neubau Wissenschaftsakademie in San Francisco/USA von Renzo Piano

    Energy Technology Data Exchange (ETDEWEB)

    Alle, Nicole; Koch, Tom

    2009-05-15

    In September 2008, the new building of the California Academy of Science was inaugurated. It is a building of superlatives. Not only is it the world's biggest public building with Leed Platinum certificate but also an example of integrative architecture which cites the history and architecture of San Francisco. The building structure and shell are based on solar engineering and on the knowledge of bionics. (orig.)

  14. A Política Econômica Regional do Vale do São Francisco: Uma Busca do Desenvolvimento do Interior Brasileiro

    Directory of Open Access Journals (Sweden)

    José Vieira Camelo Filho-Zuza

    2011-06-01

    Full Text Available O rio São Francisco é um marco econômico do interior do Brasil desde o século XVI, com o desenvolvimento da pecuária no seu Vale e este trabalho procura contribuir com a discussão a respeito da política econômica regional aplicada nesta parte do país. A água é a principal riqueza do rio e do seu Vale e foco das atividades econômicas no decorrer de 6 décadas, cuja política de desenvolvimento regional é a mais antiga do País, iniciada com a criação da empresa estatal Companhia Hidrelétrica do São Francisco -CHESF, em 1945. No ano seguinte, a nova Constituição do País estabeleceu que 1% do orçamento da União deveria ser destinado ao desenvolvimento do Vale do Francisco durante 20 anos. Em 1948, o Governo Central criou a Comissão do Vale do São Francisco - CVSF para realizar a infra-estrutura do Vale, mas foi substituída pela Superintendência do Vale do São Francisco - SUVALE, em 1967. A partir de 1974, a SUVALE deu lugar a Companhia de Desenvolvimento do Vale do São Francisco - CODEVASF, empresa responsável pelo desenvolvimento do Vale. Paralelamente esta região vem recebendo uma série investimentos públicos e privados como a implantação da Universidade Federal do Vale do São Francisco- UNIVASF em 2003. O início das obras de transferência de água do São Francisco para outras bacias hidrográficas e da E.F. Transnordestina, ambas em 2007.

  15. Acculturation, Dietary Practices and Risk for Childhood Obesity in an Ethnically Heterogeneous Population of Latino School Children in the San Francisco Bay Area

    OpenAIRE

    Wojcicki, Janet M.; Schwartz, Norah; Jiménez-Cruz, Arturo; Bacardi-Gascon, Montserrat; Heyman, Melvin B.

    2012-01-01

    Previous studies have found increased acculturation to the US lifestyle increases risk for obesity in Latinos. However, methodologies differ, and results in children are inconsistent. Moreover, previous studies have not evaluated risk factors within the heterogeneous US population. We recruited 144 self-identified Latino school children and their mother or father in grades 4–6 in San Francisco parochial schools and South San Francisco public schools using an information letter distributed to ...

  16. Citologia do desenvolvimento dos frutos sem sementes no café "mundo novo" Cytology of the development of empty fruits in the mundo novo coffee

    Directory of Open Access Journals (Sweden)

    A. J. T. Mendes

    1954-01-01

    Full Text Available Uma pequena porcentagem de frutos sem sementes é comum às plantas de tôdas as variedades de Coffea arabica, parecendo tratar-se de um fenômeno puramente fisiológico. No café Mundo Novo porém, além dêste tipo de plantas, há outras com elevada porcentagem de lojas vazias ("chochos". Constituindo isto um grave defeito para uma variedade comercial, procurou-se estudar a sua causa. As observações feitas no processo da microsporogênese mostraram irregularidades na distribuição dos cromossômios. Sendo encontradas tanto nas plantas de alta porcentagem como nas de baixa porcentagem de chochos, não deve residir nessas anomalias a causa procurada. Em estudos comparativos dos dois tipos de plantas do Mundo Novo e da variedade bourbon, pôde-se verificar : a que, em linhas gerais, o processo da formação do saco embrionário e o desenvolvimento do endosperma e do embrião são idênticos, havendo um ligeiro atrazo para as plantas Mundo Novo ; b que nestas últimas existem anormalidades diversas no saco embrionário, em proporção muito mais elevada do que no bourbon. Ocorrendo com igual freqüência nos dois tipos de plantas do café Mundo Novo, estas anormalidades também não devem se relacionar com a formação de chochos. Estudos realizados em frutos de diversas idades, permitiram relacionar a alta freqüência de lojas vazias com o aparecimento de uma estrutura anormal, em forma de disco, encontrada no interior dos restos de perisperma. Êste "disco" (com cêrca de 3 mm de diâmetro só apareceu na planta de alta freqüência de chochos, não tendo sido constatado na planta Mundo Novo de baixa freqüência de chochos, nem na planta bourbon. O exame citológico revelou que essa estrutura é constituida de endosperma, contendo um embrião anormal ; de côr clara a princípio, torna-se pardacenta à medida que degenera ; recebeu a denominação de "endosperma discóide". De oito plantas examinadas a seguir, encontrou-se endosperma disc

  17. A Pareto Algorithm for Efficient De Novo Design of Multi-functional Molecules.

    Science.gov (United States)

    Daeyaert, Frits; Deem, Micheal W

    2017-01-01

    We have introduced a Pareto sorting algorithm into Synopsis, a de novo design program that generates synthesizable molecules with desirable properties. We give a detailed description of the algorithm and illustrate its working in 2 different de novo design settings: the design of putative dual and selective FGFR and VEGFR inhibitors, and the successful design of organic structure determining agents (OSDAs) for the synthesis of zeolites. We show that the introduction of Pareto sorting not only enables the simultaneous optimization of multiple properties but also greatly improves the performance of the algorithm to generate molecules with hard-to-meet constraints. This in turn allows us to suggest approaches to address the problem of false positive hits in de novo structure based drug design by introducing structural and physicochemical constraints in the designed molecules, and by forcing essential interactions between these molecules and their target receptor. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. [A de novo mutation of P gene causes oculocutaneous albinism type 2 with prenatal diagnosis].

    Science.gov (United States)

    Zhang, Liyun; Xu, Bei; Zhong, Yanfang; Chen, Xiaofei; Zheng, Hui; Jiang, Weiying; Li, Hongyi

    2013-06-01

    To determine the genotype of a family affected with oculocutaneous albinism (OCA) and to provide genetic counseling and prenatal diagnosis. To determine the genotypes and mutational sites through PCR and sequencing for all exons and exon-intron junctions of 4 OCA genes in the proband and the P gene of her parents. Prenatal genotyping of the fetus was carried out using amniocentesis sample. The patient was diagnosed with OCA2 based on a genotype of c.1327G>A/c.2360C>T. Her father was heterozygous for c.2360C> T, whilst her mother has none of the two mutations. c.1327G>A is therefore a maternal de novo mutation. Neither of the mutations was found in the fetus. A maternally inherited de novo mutation c.1327G>A has been identified in the patient. In order to detect de novo mutations, full sequence analysis is necessary.

  19. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

    DEFF Research Database (Denmark)

    Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent

    2017-01-01

    Hundreds of thousands of human genomes are now being sequenced to characterize genetic variation and use this information to augment association mapping studies of complex disorders and other phenotypic traits. Genetic variation is identified mainly by mapping short reads to the reference genome......-coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set...... or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high...

  20. The NOVO Network: the original scientific basis for its establishment and our R&D vision

    DEFF Research Database (Denmark)

    Winkel, Jørgen; Edwards, Kasper; Dellve, L.

    2017-01-01

    The NOVO network is a Nordic non-governmental professional association whose aims are to foster the scientific progress, knowledge and development of the working environment within Healthcare as an integrated part of production system development. The vision is a “Nordic Model for Sustainable...... health effects – particularly within healthcare. This was the basis for creating the NOVO triangle emphasizing that intervention research for improved work environment in healthcare also needs to consider efficiency and quality aspects to increase organizational sustainability; i.e. the joint...... for development of more sustainable production systems in healthcare”. Future R&D performed within the framework of our NOVO network should substantiate this hypothesis. In practical terms, this necessitates expanded research protocols....

  1. Redefining the role of de novo fatty acid synthesis in Plasmodium parasites.

    Science.gov (United States)

    Tarun, Alice S; Vaughan, Ashley M; Kappe, Stefan H I

    2009-12-01

    Fatty acids are essential components of membranes, and are also involved in cell signalling. Plasmodium, the parasite that causes malaria, scavenges fatty acids from its hosts. However, Plasmodium also possesses enzymes for a prokaryotic-like de novo fatty acid synthesis pathway, which resides in the apicoplast. Recent research has demonstrated that Plasmodium parasites depend on de novo fatty acid synthesis only for liver-stage development. This finding demonstrates that basic anabolic functions of Plasmodium parasites are not necessary for the growth and replication of every life cycle stage. We discuss the role of fatty acid metabolism in Plasmodium and why we believe that de novo fatty acid synthesis is only required for parasite late liver-stage development.

  2. Defining the maize transcriptome de novo using deep RNA-Seq

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Jeffrey; Gross, Stephen; Choi, Cindy; Zhang, Tao; Lindquist, Erika; Wei, Chia-Lin; Wang, Zhong

    2011-06-01

    De novo assembly of the transcriptome is crucial for functional genomics studies in bioenergy research, since many of the organisms lack high quality reference genomes. In a previous study we successfully de novo assembled simple eukaryote transcriptomes exclusively from short Illumina RNA-Seq reads [1]. However, extensive alternative splicing, present in most of the higher eukaryotes, poses a significant challenge for current short read assembly processes. Furthermore, the size of next-generation datasets, often large for plant genomes, presents an informatics challenge. To tackle these challenges we present a combined experimental and informatics strategy for de novo assembly in higher eukaryotes. Using maize as a test case, preliminary results suggest our approach can resolve transcript variants and improve gene annotations.

  3. Defining the maize transcriptome de novo using deep RNA-Seq

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Jeffrey; Gross, Stephen; Choi, Cindy; Zhang, Tao; Lindquist, Erika; Wei, Chia-Lin; Wang, Zhong

    2011-06-02

    De novo assembly of the transcriptome is crucial for functional genomics studies in bioenergy research, since many of the organisms lack high quality reference genomes. In a previous study we successfully de novo assembled simple eukaryote transcriptomes exclusively from short Illumina RNA-Seq reads [1]. However, extensive alternative splicing, present in most of the higher eukaryotes, poses a significant challenge for current short read assembly processes. Furthermore, the size of next-generation datasets, often large for plant genomes, presents an informatics challenge. To tackle these challenges we present a combined experimental and informatics strategy for de novo assembly in higher eukaryotes. Using maize as a test case, preliminary results suggest our approach can resolve transcript variants and improve gene annotations.

  4. A suite of de novo c-type cytochromes for functional oxidoreductase engineering.

    Science.gov (United States)

    Watkins, Daniel W; Armstrong, Craig T; Beesley, Joseph L; Marsh, Jane E; Jenkins, Jonathan M X; Sessions, Richard B; Mann, Stephen; Ross Anderson, J L

    2016-05-01

    Central to the design of an efficient de novo enzyme is a robust yet mutable protein scaffold. The maquette approach to protein design offers precisely this, employing simple four-α-helix bundle scaffolds devoid of evolutionary complexity and with proven tolerance towards iterative protein engineering. We recently described the design of C2, a de novo designed c-type cytochrome maquette that undergoes post-translational modification in E. coli to covalently graft heme onto the protein backbone in vivo. This de novo cytochrome is capable of reversible oxygen binding, an obligate step in the catalytic cycle of many oxygen-activating oxidoreductases. Here we demonstrate the flexibility of both the maquette platform and the post-translational machinery of E. coli by creating a suite of functional de novo designed c-type cytochromes. We explore the engineering tolerances of the maquette by selecting alternative binding sites for heme C attachment and creating di-heme maquettes either by appending an additional heme C binding motif to the maquette scaffold or by binding heme B through simple bis-histidine ligation to a second binding site. The new designs retain the essential properties of the parent design but with significant improvements in structural stability. Molecular dynamics simulations aid the rationalization of these functional improvements while providing insight into the rules for engineering heme C binding sites in future iterations. This versatile, functional suite of de novo c-type cytochromes shows significant promise in providing robust platforms for the future engineering of de novo oxygen-activating oxidoreductases. This article is part of a Special Issue entitled Biodesign for Bioenergetics--the design and engineering of electron transfer cofactors, proteins and protein networks, edited by Ronald L. Koder and J.L. Ross Anderson. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. De novo cancers following liver transplantation: a single center experience in China.

    Directory of Open Access Journals (Sweden)

    Songfeng Yu

    Full Text Available BACKGROUND: De novo cancers are a growing problem that has become one of the leading causes of late mortality after liver transplantation. The incidences and risk factors varied among literatures and fewer concerned the Eastern population. AIMS: The aim of this study was to examine the incidence and clinical features of de novo cancers after liver transplantation in a single Chinese center. METHODS: 569 patients who received liver transplantation and survived for more than 3 months in a single Chinese center were retrospectively reviewed. RESULTS: A total of 18 de novo cancers were diagnosed in 17 recipients (13 male and 4 female after a mean of 41 ± 26 months, with an overall incidence of 3.2%, which was lower than that in Western people. Of these, 8 (3.32% cases were from 241 recipients with malignant liver diseases before transplant, while 10 (3.05% cases were from 328 recipients with benign diseases. The incidence rates were comparable, p = 0.86. Furthermore, 2 cases developed in 1 year, 5 cases in 3 years and 11 cases over 3 years. The most frequent cancers developed after liver transplantation were similar to those in the general Chinese population but had much higher incidence rates. CONCLUSIONS: Liver transplant recipients were at increased risk for developing de novo cancers. The incidence rates and pattern of de novo cancers in Chinese population are different from Western people due to racial and social factors. Pre-transplant malignant condition had no relationship to de novo cancer. Exact risk factors need further studies.

  6. Risk factors for de novo hepatitis B infection in pediatric living donor liver transplantation.

    Science.gov (United States)

    Rao, Wei; Xie, Man; Yang, Tao; Zhang, Jian-Jun; Gao, Wei; Deng, Yong-Lin; Zheng, Hong; Pan, Cheng; Liu, Yi-He; Shen, Zhong-Yang

    2014-09-28

    To investigate the incidence of de novo hepatitis B virus (HBV) infection after pediatric living donor liver transplantation (LDLT) and to analyze the risk factors associated with this de novo HBV infection. The clinical and laboratory data of children who underwent LDLT from June 2010 to September 2012 in First Center Hospital in Tianjin, China, were retrospectively included in the study. Intrahepatic HBV DNA in donors and recipients was quantified by real-time polymerase chain reaction using DNA extracted from formalin-fixed, paraffin-embedded tissues. Between June 2010 to September 2012, 32 consecutive pediatric patients underwent LDLT in our institute. Thirty LDLT patients (13 girls and 17 boys) were followed up for a median of 15 mo, of whom 53.3% (16/30) were hepatitis B core antibody (HBcAb) positive and 36.7% (11/30) were hepatitis B surface antibody (HBsAb)/HBcAb positive before transplantation. Sixteen of the children received HBcAb-positive allografts, and 43.7% (7/16) of the grafts were found to be intrahepatic HBV DNA positive. De novo HBV infection developed in 16.1% (5/30) of the children within a median of 11 mo after transplantation. All five of the HBV-infected children had received HBcAb-positive allografts, four of which were intrahepatic HBV DNA positive. Two of the children developed de novo HBV infection despite the preoperative presence of both HBsAb and HBcAb In pediatric recipients, positive intrahepatic HBV DNA in allografts could be a risk factor for de novo HBV infection from HBcAb-positive allografts. HBsAb/HBcAb positivity in pediatric LDLT patients before transplantation exhibited only weak effectiveness in protecting them against de novo HBV infection from HBcAb-positive allografts.

  7. Reaction-driven de novo design, synthesis and testing of potential type II kinase inhibitors.

    Science.gov (United States)

    Schneider, Gisbert; Geppert, Tim; Hartenfeller, Markus; Reisen, Felix; Klenner, Alexander; Reutlinger, Michael; Hähnke, Volker; Hiss, Jan A; Zettl, Heiko; Keppner, Sarah; Spänkuch, Birgit; Schneider, Petra

    2011-03-01

    De novo design of drug-like compounds with a desired pharmacological activity profile has become feasible through innovative computer algorithms. Fragment-based design and simulated chemical reactions allow for the rapid generation of candidate compounds as blueprints for organic synthesis. We used a combination of complementary virtual-screening tools for the analysis of de novo designed compounds that were generated with the aim to inhibit inactive polo-like kinase 1 (Plk1), a target for the development of cancer therapeutics. A homology model of the inactive state of Plk1 was constructed and the nucleotide binding pocket conformations in the DFG-in and DFG-out state were compared. The de novo-designed compounds were analyzed using pharmacophore matching, structure-activity landscape analysis, and automated ligand docking. One compound was synthesized and tested in vitro. The majority of the designed compounds possess a generic architecture present in known kinase inhibitors. Predictions favor kinases as targets of these compounds but also suggest potential off-target effects. Several bioisosteric replacements were suggested, and de novo designed compounds were assessed by automated docking for potential binding preference toward the inactive (type II inhibitors) over the active conformation (type I inhibitors) of the kinase ATP binding site. One selected compound was successfully synthesized as suggested by the software. The de novo-designed compound exhibited inhibitory activity against inactive Plk1 in vitro, but did not show significant inhibition of active Plk1 and 38 other kinases tested. Computer-based de novo design of screening candidates in combination with ligand- and receptor-based virtual screening generates motivated suggestions for focused library design in hit and lead discovery. Attractive, synthetically accessible compounds can be obtained together with predicted on- and off-target profiles and desired activities.

  8. Distribution and demography of San Francisco gartersnakes (Thamnophis sirtalis tetrataenia) at Mindego Ranch, Russian Ridge Open Space Preserve, San Mateo County, California

    Science.gov (United States)

    Kim, Richard; Halstead, Brian J.; Wylie, Glenn D.; Casazza, Michael L.

    2018-04-26

    San Francisco gartersnakes (Thamnophis sirtalis tetrataenia) are a subspecies of common gartersnakes endemic to the San Francisco Peninsula of northern California. Because of habitat loss and collection for the pet trade, San Francisco gartersnakes were listed as endangered under the precursor to the Federal Endangered Species Act. A population of San Francisco gartersnakes resides at Mindego Ranch, San Mateo County, which is part of the Russian Ridge Open Space Preserve owned and managed by the Midpeninsula Regional Open Space District (MROSD). Because the site contained non-native fishes and American bullfrogs (Lithobates catesbeianus), MROSD implemented management to eliminate or reduce the abundance of these non-native species in 2014. We monitored the population using capture-mark-recapture techniques to document changes in the population during and following management actions. Although drought confounded some aspects of inference about the effects of management, prey and San Francisco gartersnake populations generally increased following draining of Aquatic Feature 3. Continued management of the site to keep invasive aquatic predators from recolonizing or increasing in abundance, as well as vegetation management that promotes heterogeneous grassland/shrubland near wetlands, likely would benefit this population of San Francisco gartersnakes.

  9. Crisis of the social and emergence of sociality in the new scenarios of identity. The San Francisco district of Bilbao

    Directory of Open Access Journals (Sweden)

    Beatriz Cavia

    2008-09-01

    Full Text Available The San Francisco district in Bilbao (Spain is undergoing a deep process of urban transformation in which there is a convergence of different dynamics —economic (property speculation, social (appearance of associations and social movements and political (rehabilitation plans. In order to explain this transformation, we test two hypotheses in the article: gentrification and the crisis of the social institutions (politics, religion and work that traditionally articulated society. To counterbalance the shortcomings of the two hypotheses we redefine them as mere “conditions of possibility” of the emergence of new forms of sociality, the depoliticisation of signifieds and the production of new spaces. San Francisco constitutes a variable cronotope that provokes a blurring in sociological configurations and in social norms and sanctions.

  10. Mercury in birds of San Francisco Bay-Delta, California: trophic pathways, bioaccumulation, and ecotoxicological risk to avian reproduction

    Science.gov (United States)

    Ackerman, Joshua T.; Eagles-Smith, Collin A.; Heinz, Gary; De La Cruz, Susan E. W.; Takekawa, John Y.; Miles, A. Keith; Adelsbach, Terrence L.; Herzog, Mark P.; Bluso-Demers, Jill D.; Demers, Scott A.; Herring, Garth; Hoffman, David J.; Hartman, Christopher A.; Willacker, James J.; Suchanek, Thomas H.; Schwarzbach, Steven E.; Maurer, Thomas C.

    2014-01-01

    San Francisco Bay Estuary in northern California has a legacy of mercury contamination, which could reduce the health and reproductive success of waterbirds in the estuary. The goal of this study was to use an integrated field and laboratory approach to evaluate the risks of mercury exposure to birds in the estuary. We examined mercury bioaccumulation, and other contaminants of concern, in five waterbird species that depend heavily on San Francisco Bay Estuary for foraging and breeding habitat: American avocets (Recurvirostra americana), black-necked stilts (Himantopus mexicanus), Forster’s terns (Sterna forsteri), Caspian terns (Hydroprogne caspia), and surf scoters (Melanitta perspicillata). These species have different foraging habitats and diets that represent three distinct foraging guilds within the estuary’s food web. In this report, we provide an integrated synthesis of the primary findings from this study and results are synthesized from 54 peer-reviewed publications generated to date with other unpublished results.

  11. Destigmatizing hepatitis B in the Asian American community: lessons learned from the San Francisco Hep B Free Campaign.

    Science.gov (United States)

    Yoo, Grace J; Fang, Ted; Zola, Janet; Dariotis, Wei Ming

    2012-03-01

    Compared to any other racial/ethnic group, Asian Americans represent a population disproportionately affected by hepatitis B virus (HBV) infection, a leading cause of liver cancer. Since 2007, the San Francisco Hep B Free (SFHBF) Campaign has been actively creating awareness and education on the importance of screening, testing, and vaccination of HBV among Asian Americans. In order to understand what messages resonated with Asian Americans in San Francisco, key informant interviews with 23 (n = 23) individuals involved in community outreach were conducted. A key finding was the ability of the SFHBF campaign to utilize unique health communication strategies to break the silence and normalize discussions of HBV. In addition, the campaign's approach to using public disclosures and motivating action by emphasizing solutions towards ending HBV proved to resonate with Asian Americans. The findings and lessons learned have implications for not only HBV but other stigmatized health issues in the Asian American community.

  12. [The gallery forests of the São Francisco river as corridors for Euglossine bees (Hymenoptera: Apidae) from tropical rainforests].

    Science.gov (United States)

    Moura, Debora C; Schlindwein, Clemens

    2009-01-01

    Euglossini are typical bees of Neotropical rainforests and only a few species occur in the Caatinga. The São Francisco river, which is the only permanent river in the semi-arid NE-Brazil, is bordered by a gallery forest with evergreen leaves. This environment offers flooral rewards along the year. Surveys of euglossine bees by attracting males to scent baits showed that species of the Atlantic Rainforest like Euglossa imperialis Cockerel, E. truncata Moure and Eulaema cingulata Fabricius occur in the gallery forest of the São Francisco river under the semi-arid climate of the caatinga region. These bees are restricted to the gallery forests which function as bio-corridors, and are absent at places where the forests were cut down. This emphasizes the need to protect the threatened gallery forests to maintain biodiversity.

  13. Promoting Health and Safety in San Francisco's Chinatown Restaurants: Findings and Lessons Learned from a Pilot Observational Checklist

    Science.gov (United States)

    Gaydos, Megan; Bhatia, Rajiv; Morales, Alvaro; Lee, Pam Tau; Liu, Shaw San; Chang, Charlotte; Salvatore, Alicia L.; Krause, Niklas; Minkler, Meredith

    2011-01-01

    Noncompliance with labor and occupational health and safety laws contributes to economic and health inequities. Environmental health agencies are well positioned to monitor workplace conditions in many industries and support enhanced enforcement by responsible regulatory agencies. In collaboration with university and community partners, the San Francisco Department of Public Health used an observational checklist to assess preventable occupational injury hazards and compliance with employee notification requirements in 106 restaurants in San Francisco's Chinatown. Sixty-five percent of restaurants had not posted required minimum wage, paid sick leave, or workers' compensation notifications; 82% of restaurants lacked fully stocked first-aid kits; 52% lacked antislip mats; 37% lacked adequate ventilation; and 28% lacked adequate lighting. Supported by a larger community-based participatory research process, this pilot project helped to spur additional innovative health department collaborations to promote healthier workplaces. PMID:21836739

  14. Shifting shoals and shattered rocks : How man has transformed the floor of west-central San Francisco Bay

    Science.gov (United States)

    Chin, John L.; Wong, Florence L.; Carlson, Paul R.

    2004-01-01

    San Francisco Bay, one of the world's finest natural harbors and a major center for maritime trade, is referred to as the 'Gateway to the Pacific Rim.' The bay is an urbanized estuary that is considered by many to be the major estuary in the United States most modified by man's activities. The population around the estuary has grown rapidly since the 1850's and now exceeds 7 million people. The San Francisco Bay area's economy ranks as one of the largest in the world, larger even than that of many countries. More than 10 million tourists are estimated to visit the bay region each year. The bay area's population and associated development have increasingly changed the estuary and its environment. San Francisco Bay and the contiguous Sacramento-San Joaquin Delta encompass roughly 1,600 square miles (4,100 km2) and are the outlet of a major watershed that drains more than 40 percent of the land area of the State of California. This watershed provides drinking water for 20 million people (two thirds of the State's population) and irrigates 4.5 million acres of farmland and ranchland. During the past several decades, much has been done to clean up the environment and waters of San Francisco Bay. Conservationist groups have even bought many areas on the margins of the bay with the intention of restoring them to a condition more like the natural marshes they once were. However, many of the major manmade changes to the bay's environment occurred so long ago that the nature of them has been forgotten. In addition, many changes continue to occur today, such as the introduction of exotic species and the loss of commercial and sport fisheries because of declining fish populations. The economy and population of the nine counties that surround the bay continue to grow and put increasing pressure on the bay, both direct and indirect. Therefore, there are mixed signals for the future health and welfare of San Francisco Bay. The San Francisco Bay estuary consists of three

  15. Part I, Introduction: Ecology and Regional Context of Tidal Wetlands in the San Francisco Bay National Estuarine Research Reserve

    Directory of Open Access Journals (Sweden)

    Matthew C. Ferner

    2011-12-01

    Full Text Available This two-part special issue reviews the basic ecology of tidal wetlands in the San Francisco Estuary. Several articles highlight the well-preserved tracts of historic tidal marsh found at China Camp State Park and Rush Ranch Open Space Preserve. These two protected areas serve as important reference sites for wetland restoration and conservation and also comprise San Francisco Bay National Estuarine Research Reserve (SF Bay NERR. SF Bay NERR is part of the National Oceanic and Atmospheric Administration’s nationwide network of 28 estuarine research reserves (http://www.nerrs.noaa.gov that all share common goals: (1 conducting standardized long-term monitoring, (2 supporting applied environmental research, (3 providing stewardship of estuarine natural resources, and (4 linking science with decision making in pursuit of effective solutions to coastal management problems.

  16. The Performance of Nearshore Dredge Disposal at Ocean Beach, San Francisco, California, 2005-2007

    Science.gov (United States)

    Barnard, Patrick L.; Erikson, Li H.; Hansen, Jeff E.; Elias, Edwin

    2009-01-01

    Ocean Beach, California, contains an erosion hot spot in the shadow of the San Francisco ebb tidal delta that threatens valuable public infrastructure as well as the safe recreational use of the beach. In an effort to reduce the erosion at this location a new plan for the management of sediment dredged annually from the main shipping channel at the mouth of San Francisco Bay was implemented in May 2005 by the United States Army Corps of Engineers, San Francisco District (USACE). The USACE designated a temporary nearshore dredge disposal site for the annual disposal of about 230,000 m3 (300,000 yd3) of sand about 750 m offshore and slightly south of the erosion hot spot, in depths between approximately 9 and 14 m. The site has now been used three times for a total sediment disposal of about 690,000 m3 (about 900,000 yds3). The disposal site was chosen because it is in a location where strong tidal currents and open-ocean waves can potentially feed sediment toward the littoral zone in the reach of the beach that is experiencing critical erosion, as well as prevent further scour on an exposed outfall pipe. The onshore migration of sediment from the target disposal location might feed the primary longshore bar or the nearshore zone, and provide a buffer to erosion that peaks during winter months when large waves impact the region. The United States Geological Survey (USGS) has been monitoring and modeling the bathymetric evolution of the test dredge disposal site and the adjacent coastal region since inception in May 2005. This paper reports on the first 2.5 years of this monitoring program effort (May 2005 to December 2007) and assesses the short-term coastal response. Here are the key findings of this report: *Approximately half of the sediment that has been placed in the nearshore dredge-disposal site during the 2.5 years of this study remains within the dredge focus area. *In the winter of 2006-7, large waves transported the dredge-mound material onshore. *High

  17. Francisco de Aguiar y Seijas, pastor del rebaño

    Directory of Open Access Journals (Sweden)

    Silva Herrera, Rocío

    2014-12-01

    Full Text Available Which was the pastoral profile of Francisco de Aguiar y Seijas, archbishop of Mexico? Through the dates of the Book of visit in his fourth journey in the regions of Chalco, Amilpas, Xochimilco and Coyoacan from december 4th 1686 to april 9th 1687, and making use of the thematic biography as method, the answer to the initial question has arrived. After the Council of Trent, the bishop had the duty to promote the reform of customs in his diocese; the pastoral visit was a privileged way to achieve it. The archbishop Aguiar, educated from the tridentine discipline in the archdiocese of Santiago de Compostela, made of his pastoral visit a really popular mission among the people. He takes a small itinerant curia, to govern and discharging justice in a delegated manner. A disciplined, austere and conciliator man, he served as a souls shepherd more than a court official.¿Cuál fue el perfil pastoral de Francisco de Aguiar y Seijas, arzobispo de México? A través de los datos que aporta el Libro de visita de su cuarta salida a las regiones de Chalco, Amilpas, Xochimilco y Coyoacán del 4 de diciembre de 1686 al 9 de abril de 1687, y utilizando la metodología de la biografía temática, se ha dado respuesta a la pregunta inicial. Luego del Concilio de Trento, el obispo tenía el grave deber de suscitar la reforma de las costumbres en su diócesis; la visita pastoral fue un medio privilegiado para lograrlo. El arzobispo Aguiar, formado bajo la disciplina tridentina en la arquidiócesis compostelana, hizo de su visita pastoral una verdadera misión popular entre la gente. Acompañado de una pequeña curia itinerante, gobernó e impartió justicia con características de delegación de poder. Hombre disciplinado, austero y de carácter conciliador se dirigió más como pastor de almas que como funcionario real. [gl] Cal foi o perfil pastoral de Francisco de Aguiar e Seijas, arcebispo de México? A través dos datos que achega o libro de visita da s

  18. Detection of de novo synthesized form of microsomal cytochrome P-448 by autofluorography

    Energy Technology Data Exchange (ETDEWEB)

    Chasonikova, O.B.; Lab. of Xenobiochemistry, Inst. of Clinical and Experimental Medicine, Siberian Branch, Academy of Medical Sciences of the USSR, Novosibirsk; Tsyrlov, I.B.

    1986-06-01

    This paper suggests a simple and informative method of detection of de novo synthesized forms of microsomal cytochrome P-450. The method is based on autofluorography of the gel after electrophoretic fractionation of liver microsomal proteins of rats previously injected with inducers of components of the monooxygenase system, followed by C 14-leucine. From the results obtained by autofluorography it is shown that during induction of the monooxygenase system of rat liver with MCh and TCDD at least two forms of cytochromes of the P-448 type with mol. wt. of 53 and 56 kd were synthesized de novo.

  19. Mechanism of increased rate of de novo purine biosynthesis in rat liver after bilateral adrenalectomy

    International Nuclear Information System (INIS)

    Itakura, M.; Maeda, N.; Yamashita, K.

    1986-01-01

    The incorporation of C-14-glycine to hepatic purines increased proving the increased rate of de novo purine biosynthesis in rat liver after bilateral adrenalectomy in comparison to sham-operated controls It is shown that the increased rate of de novo purine biosynthesis in adrenalectomized rat liver is compensatory against the increased catabolism of purine ribonucleotides as a result of the increased AMP concentration and that it is mediated by the increased concentration of PRPP. The study demonstrates the importance of the physiological amount of adrenocortical hormone to sustain the normal concentrations nad the metabolism of purine ribonucleotides in liver

  20. AS CARTAS CATÓLICAS NO CÂNON DO NOVO TESTAMENTO

    OpenAIRE

    Waldecir Gonzaga

    2017-01-01

    RESUMO: Nossa intenção, neste artigo, é oferecer um estudo acerca deste conjunto das cartas do Novo Testamento intituladas Cartas Católicas, que desde a antiguidade têm enfrentado não poucos ou indiferentes problemas, seja na aceitação seja no estudo de seu corpus, como o grupo de cartas do Novo Testamento menos estudado ou explorado, mesmo em nossos seminários, faculdades e universidades religiosas em geral, sejam eles católicos ou protestantes; também cremos não ser exagero afirmar que os t...

  1. Whole-Genome de novo Sequencing Of Quail And Grey Partridge

    DEFF Research Database (Denmark)

    Holm, Lars-Erik; Panitz, Frank; Burt, Dave

    2011-01-01

    The development in sequencing methods has made it possible to perform whole genome de novo sequencing of species without large commercial interests. Within the EU-financed QUANTOMICS project (KBBE-2A-222664), we have performed de novo sequencing of quail (Coturnix coturnix) and grey partridge...... comparative studies towards the chicken genome and will aid in identifying evolutionarily conserved sequences within the Galliformes. The obtained sequences from quail and partridge represent a beginning of generating the whole genome sequence for these species. The continuation of establishing the genome...

  2. NovoTTF™-100A System (Tumor Treating Fields) transducer array layout planning for glioblastoma: a NovoTAL™ system user study.

    Science.gov (United States)

    Chaudhry, Aafia; Benson, Laura; Varshaver, Michael; Farber, Ori; Weinberg, Uri; Kirson, Eilon; Palti, Yoram

    2015-11-11

    Optune™, previously known as the NovoTTF-100A System™, generates Tumor Treating Fields (TTFields), an effective anti-mitotic therapy for glioblastoma. The system delivers intermediate frequency, alternating electric fields to the supratentorial brain. Patient therapy is personalized by configuring transducer array layout placement on the scalp to the tumor site using MRI measurements and the NovoTAL System. Transducer array layout mapping optimizes therapy by maximizing electric field intensity to the tumor site. This study evaluated physician performance in conducting transducer array layout mapping using the NovoTAL System compared with mapping performed by the Novocure in-house clinical team. Fourteen physicians (7 neuro-oncologists, 4 medical oncologists, and 3 neurosurgeons) evaluated five blinded cases of recurrent glioblastoma and performed head size and tumor location measurements using a standard Digital Imaging and Communications in Medicine reader. Concordance with Novocure measurement and intra- and inter-rater reliability were assessed using relevant correlation coefficients. The study criterion for success was a concordance correlation coefficient (CCC) >0.80. CCC for each physician versus Novocure on 20 MRI measurements was 0.96 (standard deviation, SD ± 0.03, range 0.90-1.00), indicating very high agreement between the two groups. Intra- and inter-rater reliability correlation coefficients were similarly high: 0.83 (SD ±0.15, range 0.54-1.00) and 0.80 (SD ±0.18, range 0.48-1.00), respectively. This user study demonstrated an excellent level of concordance between prescribing physicians and Novocure in-house clinical teams in performing transducer array layout planning. Intra-rater reliability was very high, indicating reproducible performance. Physicians prescribing TTFields, when trained on the NovoTAL System, can independently perform transducer array layout mapping required for the initiation and maintenance of patients on TTFields

  3. Sub-tidal benthic habitats of central San Francisco Bay and offshore Golden Gate area: A review

    Science.gov (United States)

    Greene, H. Gary; Endris, Charles; Vallier, Tracy; Golden, Nadine E.; Cross, Jeffery; Ryan, Holly F.; Dieter, Bryan; Niven, Eric; Barnard, P.L.; Jaffee, B.E.; Schoellhamer, D.H.

    2013-01-01

    Deep-water potential estuarine and marine benthic habitat types were defined from a variety of new and interpreted data sets in central San Francisco Bay and offshore Golden Gate area including multibeam echosounder (MBES), side-scan sonar and bottom grab samples. Potential estuarine benthic habitats identified for the first time range from hard bedrock outcrops on island and mainland flanks and some Bay floor

  4. Romantic Relationships and Their Social Context Among Gay/Bisexual Male Youth in the Castro District of San Francisco

    OpenAIRE

    Strong, Thomas

    2007-01-01

    This article examines the culture of romantic relationships among gay/bisexual male youth in the Castro District of San Francisco.The article seeks to specify the cultural ideology that informs these relationships, drawing upon ethnographic observation, autobiographical accounts, and informant cultural exegesis. The article also seeks to link thinking and experience inside romantic relationships (e.g., bonding, jealousy) to patterns of social behavior associated with romantic r...

  5. Cannabis dependence in the San Francisco Family Study: age of onset of use, DSM-IV symptoms, withdrawal, and heritability

    OpenAIRE

    Ehlers, Cindy L.; Gizer, Ian R.; Vieten, Cassandra; Gilder, David A.; Stouffer, Gina M.; Lau, Philip; Wilhelmsen, Kirk C.

    2009-01-01

    Cannabis is the most widely used illicit drug in the United States, yet the role of genetics in individual symptoms associated with cannabis use disorders has not been evaluated. The purpose of the present set of analyses was to describe the symptomatology and estimate the heritability of DSM-IV criteria/symptoms of cannabis dependence in a large sample of families. Participants were 2524 adults, participating in the University of California San Francisco (UCSF) Family Study of alcoholism. Se...

  6. Ground motion modeling of the 1906 San Francisco earthquake II: Ground motion estimates for the 1906 earthquake and scenario events

    Energy Technology Data Exchange (ETDEWEB)

    Aagaard, B; Brocher, T; Dreger, D; Frankel, A; Graves, R; Harmsen, S; Hartzell, S; Larsen, S; McCandless, K; Nilsson, S; Petersson, N A; Rodgers, A; Sjogreen, B; Tkalcic, H; Zoback, M L

    2007-02-09

    We estimate the ground motions produced by the 1906 San Francisco earthquake making use of the recently developed Song et al. (2008) source model that combines the available geodetic and seismic observations and recently constructed 3D geologic and seismic velocity models. Our estimates of the ground motions for the 1906 earthquake are consistent across five ground-motion modeling groups employing different wave propagation codes and simulation domains. The simulations successfully reproduce the main features of the Boatwright and Bundock (2005) ShakeMap, but tend to over predict the intensity of shaking by 0.1-0.5 modified Mercalli intensity (MMI) units. Velocity waveforms at sites throughout the San Francisco Bay Area exhibit characteristics consistent with rupture directivity, local geologic conditions (e.g., sedimentary basins), and the large size of the event (e.g., durations of strong shaking lasting tens of seconds). We also compute ground motions for seven hypothetical scenarios rupturing the same extent of the northern San Andreas fault, considering three additional hypocenters and an additional, random distribution of slip. Rupture directivity exerts the strongest influence on the variations in shaking, although sedimentary basins do consistently contribute to the response in some locations, such as Santa Rosa, Livermore, and San Jose. These scenarios suggest that future large earthquakes on the northern San Andreas fault may subject the current San Francisco Bay urban area to stronger shaking than a repeat of the 1906 earthquake. Ruptures propagating southward towards San Francisco appear to expose more of the urban area to a given intensity level than do ruptures propagating northward.

  7. Distribution and Genetic Structure of Fucus distichus Linnaeus 1953 (formerly F. gardneri within Central San Francisco Bay

    Directory of Open Access Journals (Sweden)

    Stephen G. Whitaker

    2017-09-01

    Full Text Available doi: https://doi.org/10.15447/sfews.2017v15iss3art4Fucus distichus, a rockweed common to the mid-intertidal shoreline within the San Francisco Estuary (previously known as F. gardneri, was injured during the Cosco Busan oil spill in November 2007 and subsequent clean-up actions. Restoration planning activities are underway to help recover F. distichus at sites within central San Francisco Bay where damage occurred. As a first step, we conducted shoreline surveys during the summers of 2012–2013 to map the occurrence of this rockweed. Of the 151.73 km of rocky shoreline within the central bay, F. distichus covered 32.16 km of shoreline. The alga generally occurred in narrow bands but formed expansive beds at locations with natural, flat bedrock benches. We also observed F. distichus on artificial substrata such as seawalls and riprap, but not on pilings. Samples of F. distichus from 11 sites throughout the central / east San Francisco Bay were genetically analyzed (microsatellite genotyping. The populations analyzed (1 had low genetic diversity, (2 the frequency of homozygotes was higher than expected (suggesting high inbreeding, and (3 also displayed geographic population structure, in part driven by very small differences in the midst of extremely low within-population genetic diversity. However, these genetic data do not raise concerns for restoration methods in terms of choosing donor populations and mixing F. distichus from different sites within the central bay. The choice of donor populations should be based on practical criteria for effective restoration; individuals will nonetheless be taken from locations as nearby to donor sites as possible. Various locations throughout the central San Francisco Bay are composed of cobble or small riprap that are populated with F. distichus, which could provide efficient means of translocating rockweed for future restoration activities.

  8. Achieving Health Equity Through Community Engagement in Translating Evidence to Policy: The San Francisco Health Improvement Partnership, 2010-2016.

    Science.gov (United States)

    Grumbach, Kevin; Vargas, Roberto A; Fleisher, Paula; Aragón, Tomás J; Chung, Lisa; Chawla, Colleen; Yant, Abbie; Garcia, Estela R; Santiago, Amor; Lang, Perry L; Jones, Paula; Liu, Wylie; Schmidt, Laura A

    2017-03-23

    The San Francisco Health Improvement Partnership (SFHIP) promotes health equity by using a novel collective impact model that blends community engagement with evidence-to-policy translational science. The model involves diverse stakeholders, including ethnic-based community health equity coalitions, the local public health department, hospitals and health systems, a health sciences university, a school district, the faith community, and others sectors. We report on 3 SFHIP prevention initiatives: reducing consumption of sugar sweetened beverages (SSBs), regulating retail alcohol sales, and eliminating disparities in children's oral health. SFHIP is governed by a steering committee. Partnership working groups for each initiative collaborate to 1) develop and implement action plans emphasizing feasible, scalable, translational-science-informed interventions and 2) consider sustainability early in the planning process by including policy and structural interventions. Through SFHIP's efforts, San Francisco enacted ordinances regulating sale and advertising of SSBs and a ballot measure establishing a soda tax. Most San Francisco hospitals implemented or committed to implementing healthy-beverage policies that prohibited serving or selling SSBs. SFHIP helped prevent Starbucks and Taco Bell from receiving alcohol licenses in San Francisco and helped prevent state authorization of sale of powdered alcohol. SFHIP increased the number of primary care clinics providing fluoride varnish at routine well-child visits from 3 to 14 and acquired a state waiver to allow dental clinics to be paid for dental services delivered in schools. The SFHIP model of collective impact emphasizing community engagement and policy change accomplished many of its intermediate goals to create an environment promoting health and health equity.

  9. LA OPCIÓN TEOLÓGICO-PASTORAL DEL PAPA FRANCISCO

    Directory of Open Access Journals (Sweden)

    Rafael Luciani

    2016-01-01

    Full Text Available Resumen: La Evangelii Gaudium y los discursos ofrecidos durante los viajes apostólicos a Latinoamérica han dejado clara la opción teológico-pastoral del Papa Francisco, cuyo eje se encuentra en torno a la opción preferencial por «una Iglesia pobre que asuma al pueblo-pobre» y, desde ahí, se deje evangelizar reconociendo el lugar teológico que tiene la cultura popular como mediación socioanalítica y de encuentro con el Dios de Jesús. Para comprender esto hay que adentrarse en el debate sociohistórico de la teología latinoamericana de la liberación y en el modo como esta fue recibida en Argentina por medio de la teología del pueblo. Así también, es necesario seguir los debates sobre la relación que ha de existir entre el anuncio del Evangelio, la vida de la Iglesia y la realidad de los pobres, según han sido expuestos desde Medellín hasta Aparecida. En el presente artículo iremos desarrollando estos ejes fundamentales en los que se inspira la opción teológico-pastoral del Papa Francisco y las consecuencias para la credibilidad de la comunidad cristiana en la era globalizada. Abstract: The Evangelii Gaudium and the speeches offered during the Papal Apostolic Journeys to Latin America made more clear the theological and pastoral option of Pope Francis, whose axis is around a preferential option for «a poor Church that assumes the poor-people». A Church that recognizes the theological locus of the popular culture, as a socio-analytic mediation to encounter the God of Jesus. To understand this, it is mandatory to examine the social and historical debates occasioned by Latin American Liberation Theology and the way it was received in Argentina through the so called «Theology of the People». It will also be necessary to follow the discussions on the relationship between the proclamation of the Gospel, the life of the Church and the reality of the poor, as they have been stated from Medellin and San Miguel to Aparecida. In

  10. Improving Radar Quantitative Precipitation Estimation over Complex Terrain in the San Francisco Bay Area

    Science.gov (United States)

    Cifelli, R.; Chen, H.; Chandrasekar, V.

    2017-12-01

    A recent study by the State of California's Department of Water Resources has emphasized that the San Francisco Bay Area is at risk of catastrophic flooding. Therefore, accurate quantitative precipitation estimation (QPE) and forecast (QPF) are critical for protecting life and property in this region. Compared to rain gauge and meteorological satellite, ground based radar has shown great advantages for high-resolution precipitation observations in both space and time domain. In addition, the polarization diversity shows great potential to characterize precipitation microphysics through identification of different hydrometeor types and their size and shape information. Currently, all the radars comprising the U.S. National Weather Service (NWS) Weather Surveillance Radar-1988 Doppler (WSR-88D) network are operating in dual-polarization mode. Enhancement of QPE is one of the main considerations of the dual-polarization upgrade. The San Francisco Bay Area is covered by two S-band WSR-88D radars, namely, KMUX and KDAX. However, in complex terrain like the Bay Area, it is still challenging to obtain an optimal rainfall algorithm for a given set of dual-polarization measurements. In addition, the accuracy of rain rate estimates is contingent on additional factors such as bright band contamination, vertical profile of reflectivity (VPR) correction, and partial beam blockages. This presentation aims to improve radar QPE for the Bay area using advanced dual-polarization rainfall methodologies. The benefit brought by the dual-polarization upgrade of operational radar network is assessed. In addition, a pilot study of gap fill X-band radar performance is conducted in support of regional QPE system development. This paper also presents a detailed comparison between the dual-polarization radar-derived rainfall products with various operational products including the NSSL's Multi-Radar/Multi-Sensor (MRMS) system. Quantitative evaluation of various rainfall products is achieved

  11. Understanding Urban Watersheds through Digital Interactive Maps, San Francisco Bay Area, California

    Science.gov (United States)

    Sowers, J. M.; Ticci, M. G.; Mulvey, P.

    2014-12-01

    Dense urbanization has resulted in the "disappearance" of many local creeks in urbanized areas surrounding the San Francisco Bay. Long reaches of creeks now flow in underground pipes. Municipalities and water agencies trying to reduce non-point-source pollution are faced with a public that cannot see and therefore does not understand the interconnected nature of the drainage system or its ultimate discharge to the bay. Since 1993, we have collaborated with the Oakland Museum, the San Francisco Estuary Institute, public agencies, and municipalities to create creek and watershed maps to address the need for public understanding of watershed concepts. Fifteen paper maps are now published (www.museumca.org/creeks), which have become a standard reference for educators and anyone working on local creek-related issues. We now present digital interactive creek and watershed maps in Google Earth. Four maps are completed covering urbanized areas of Santa Clara and Alameda Counties. The maps provide a 3D visualization of the watersheds, with cartography draped over the landscape in transparent colors. Each mapped area includes both Present and Past (circa 1800s) layers which can be clicked on or off by the user. The Present layers include the modern drainage network, watershed boundaries, and reservoirs. The Past layers include the 1800s-era creek systems, tidal marshes, lagoons, and other habitats. All data are developed in ArcGIS software and converted to Google Earth format. To ensure the maps are interesting and engaging, clickable icons pop-up provide information on places to visit, restoration projects, history, plants, and animals. Maps of Santa Clara Valley are available at http://www.valleywater.org/WOW.aspx. Maps of western Alameda County will soon be available at http://acfloodcontrol.org/. Digital interactive maps provide several advantages over paper maps. They are seamless within each map area, and the user can zoom in or out, and tilt, and fly over to explore

  12. High-resolution geochemical record of Petaluma Marsh from the San Francisco bay area

    Science.gov (United States)

    Fard, E.; Brown, L. N.; MacDonald, G. M.

    2017-12-01

    The San Francisco Bay has the largest concentration of salt marshes in the state of California, representing a diversity of marsh habitat. Protecting these environments is critical, as salt marshes provide refuge to endangered species, absorb carbon from the atmosphere, and preserve detailed evidence of past climatic, hydrologic, geomorphic, and ecologic conditions. However, much of the marshes have been impacted by pollutants, altered or lost entirely due to human activity over the past 150 years, making their prehistoric conditions, ecological trajectories and resilience to disturbance uncertain. In this study, we collected data from Petaluma Marsh, one of the oldest marshes in the Bay Area, to document the sedimentological and accretionary history, geochemical changes including heavy metal concentrations, and patterns and shifts in productivity and C sequestration as a response to climatic and anthropogenic changes since the mid-Holocene. Loss-on ignition, pXRF, and magnetic susceptibility data were collected at high resolution from a 12-meter, 6000 year old, sedimentary core recovered from this tidal marsh located along the Petaluma river in the northern Bay region. Average rate of sediment accretion was 3.6 ± 0.8 mm/yr. Preliminary results confirm dramatic anthropogenic impacts on the Petaluma watershed, particularly over the last 150-200 years. However, based on statistical time-series analysis of long-core elemental concentrations, results show that modern conditions are not so far removed compared to prehistoric conditions, as often suggested by century-scale analyses. Modern heavy metal concentrations (e.g., Cr, Fe, Sr, Ba, Zr, Rb and Ni) match concentration levels from 4000-5000 yr BP. However, Pb levels in the marsh post-European land use are higher now than ever before. Average carbon content, as determined from LOI (Craft, 1991), is 22.3 ± 7.5 % over the length of the core, but decreased with European land modification and increased in recent years

  13. In-situ measurements of seismic velocities in the San Francisco Bay Region; part III

    Science.gov (United States)

    Gibbs, James F.; Fumal, Thomas E.; Borcherdt, Roger D.; Roth, Edward F.

    1977-01-01

    Seismic wave velocities (compressional and shear) are important parameters for estimating the seismic response characteristics of various geologic units when subjected to strong earthquake ground shaking. Seismic velocities of various units often show a strong correlation with the amounts of damage following large earthquakes and have been used as a basis for certain types of seismic zonation studies. In the current program seismic velocities have been measured at 59 locations 1n the San Francisco Bay Region. This report is the third in a series of Open-File Reports and describes the in-situ velocity measurements at locations 35-59. At each location seismic travel times are measured in drill holes, normally at 2.5-m intervals to a depth of 30 m. Geologic logs are determined from drill cuttings, undisturbed (cored) samples, and penetrometer samples. The data provide a detailed comparison of geologic and seismic characteristics and provide parameters for estimating strong earthquake ground motions quantitatively at each of the sites. A major emphasis of this program is to obtain a detailed comparison of geologic and seismic data on a regional scale for use in seismic zonation. There is a variety of geologic and seismic data available in the San Francisco Bay Region for use 1n developing the general zoning techniques which can then be applied to other areas. Shear wave velocities 1n near-surface geologic materials are of especial interest for engineering seismology and seismic zonation studies, yet in general, they are difficult to measure because of contamination by compressional waves. A comparison of various in-situ techniques by Warrick (1974) establishes the reliability of the method utilizing a "horizontal traction" source for sites underlain by bay mud and alluvium. Gibbs, and others (1975a) present data from 12 holes and establishes the reliability of the method for sites underlain by a variety of different rock units and suggest extending the measurements to

  14. A mulher trabalhadora em Santa Maria durante o Estado Novo (1937-1945 = The woman worker in Santa Maria during the Estado Novo (1937-1945

    Directory of Open Access Journals (Sweden)

    Fausto, Letícia da Silva

    2014-01-01

    Full Text Available Este trabalho apresenta um estudo sobre a história das mulheres santamarienses no período da Ditadura do Estado Novo, que está sendo desenvolvido no Mestrado em História da Universidade Federal de Santa Maria (UFSM. O tema da pesquisa é a inserção da mulher no mundo do trabalho e sua atuação para a garantia e conquista de direitos sociais e trabalhistas durante o período do Estado Novo (1937-1945, no município de Santa Maria, RS. A escolha do Estado Novo no Brasil se deu em virtude deste ser um período onde muitas conquistas dos trabalhadores estavam sendo objeto de legislação específica e ao mesmo tempo um momento de repressão política, de forte aparato policial e repressivo e do fortalecimento dos sindicatos, sob a tutela do Estado e da luta dos trabalhadores para a garantia destes direitos, historicamente conquistados. As mulheres por séculos passaram despercebidas pela história, reprimidas em uma sociedade machista e autoritária, onde grande parte dos autores insere o homem no palco das lutas por reinvindicações e direitos trabalhistas

  15. Mercury burdens in Chinese mitten crabs (Eriocheir sinensis) in three tributaries of southern San Francisco Bay, California, USA

    International Nuclear Information System (INIS)

    Hui, Clifford A.; Rudnick, Deborah; Williams, Erin

    2005-01-01

    Chinese mitten crabs (Eriocheir sinensis), endemic to Asia, were first reported in the San Francisco Bay in 1992. They are now established in nearly all San Francisco Bay tributaries. These crabs accumulate more metals, such as mercury, than crustaceans living in the water column. Because their predators include fish, birds, mammals and humans, their mercury burdens have an exceptional potential to impact the ecosystem and public health. We sought to elucidate the potential threat of mitten crab mercury burdens in three adjacent streams in southern San Francisco Bay, one of which is known to be contaminated with mercury. Mitten crabs had hepatopancreas concentrations of total mercury and methylmercury that did not differ among streams. The maximum burden we measured was below the action level of 1 ppm recommended by the USEPA. Hepatopancreas concentrations of methylmercury declined with increasing crab size, suggesting a mechanism for mercury excretion and that predators might reduce mercury exposure if they select larger crabs. Because mercury may be heterogeneously distributed among tissues, estimation of the impacts of crab mercury burdens on the environment requires more data on the feeding preferences of predators. - Hepatopancreas concentrations of mercury decline with crab size, which may have important consequences for bio-magnification in food webs

  16. Data from theodolite measurements of creep rates on San Francisco Bay region faults, California: 1979-2001

    Science.gov (United States)

    Galehouse, Jon S.

    2002-01-01

    My purpose is to make our creep data on San Francisco Bay region active faults available to the scientific research community. My student research assistants and I measured creep (aseismic slip) rates on these faults from 1979 until my retirement from the project in 2001. These data are further described in my final technical report as principal investigator, which summarizes results from 22 September 1979 through 28 February 2001 (Galehouse, 2001). We made over 2,600 creep measurements, about one-third in the ten years prior to the Loma Prieta earthquake (LPEQ) and two-thirds in the 11.4 years following it. The measurements are continuing to be made by members of the Geosciences Department at San Francisco State University (SFSU) under the direction of Karen Grove and John Caskey. A complete analysis of our results obtained on the Hayward fault is presented in Lienkaemper, Galehouse, and Simpson (2001). A formal report based on the entire San Francisco Bay region data set is in preparation. Data sheets for each site along the fault are available for downloading in Excel format to facilitate analysis of the data. They are also available as tab-delimited raw data. The data include all regular measurement sites, SF–1 through SF–34, and the 20 SFSU and U.S. Geological Survey (USGS) afterslip sites on the Hayward fault.

  17. Changes of precipitation extremes indices in São Francisco River Basin, Brazil from 1947 to 2012

    Science.gov (United States)

    Bezerra, Bergson G.; Silva, Lindenberg L.; Santos e Silva, Claudio M.; de Carvalho, Gilvani Gomes

    2018-02-01

    The São Francisco River is strategically important due to its hydroelectric potential and for bringing the largest water body of Brazilian Semiarid region, supplying water for irrigation, urban, and industrial activities. Thereby, for the purpose of characterizing changes on the precipitation patterns over São Francisco River basin, 11 extremes precipitation indices as defined by the joint WMO/CCI/ETCCDMI/CLIVAR project were calculated using daily observation from the 59 rain gauges during 1947-2012 period. The extreme climatic indices were calculated with the RClimDex software, which performs an exhaustive data quality control, intending to identify spurious errors and dataset inconsistencies. Weak and significant regional changes were observed in both CDD and SDII indices. Most precipitation extremes indices decreased but without statistical significance. The spatial analysis of indices did not show clearly regional changes due to the complexity of hydrometeorology of the region. In some cases, two rainfall stations exhibited opposite trends with the same significance level although they are separated by a few kilometers. This has occurred more frequently in Lower-Middle São Francisco, probably associated with intense land cover change over the last decades in this region.

  18. Mercury burdens in Chinese mitten crabs (Eriocheir sinensis) in three tributaries of southern San Francisco Bay, California, USA

    Science.gov (United States)

    Hui, C.A.; Rudnick, D.; Williams, E.

    2005-01-01

    Chinese mitten crabs (Eriocheir sinensis), endemic to Asia, were first reported in the San Francisco Bay in 1992. They are now established in nearly all San Francisco Bay tributaries. These crabs accumulate more metals, such as mercury, than crustaceans living in the water column. Because their predators include fish, birds, mammals and humans, their mercury burdens have an exceptional potential to impact the ecosystem and public health. We sought to elucidate the potential threat of mitten crab mercury burdens in three adjacent streams in southern San Francisco Bay, one of which is known to be contaminated with mercury. Mitten crabs had hepatopancreas concentrations of total mercury and methylmercury that did not differ among streams. The maximum burden we measured was below the action level of 1 ppm recommended by the USEPA. Hepatopancreas concentrations of methylmercury declined with increasing crab size, suggesting a mechanism for mercury excretion and that predators might reduce mercury exposure if they select larger crabs. Because mercury may be heterogeneously distributed among tissues, estimation of the impacts of crab mercury burdens on the environment requires more data on the feeding preferences of predators. Hepatopancreas concentrations of mercury decline with crab size, which may have important consequences for bio-magnification in food webs. ?? 2004 Elsevier Ltd. All rights reserved.

  19. Drivers of change in estuarine-coastal ecosystems: Discoveries from four decades of study in San Francisco Bay

    Science.gov (United States)

    Cloern, J.E.; Jassby, A.D.

    2012-01-01

    Poised at the interface of rivers, ocean, atmosphere and dense human settlement, estuaries are driven by a large array of natural and anthropogenic forces. San Francisco Bay exemplifies the fast-paced change occurring in many of the world's estuaries, bays and inland seas in response to these diverse forces. We use observations from this particularly well-studied estuary to illustrate responses to six drivers that are common agents of change where land and sea meet: water consumption and diversion; human modification of sediment supply; introduction of non-native species; sewage input; environmental policy; and climate shifts. In San Francisco Bay, responses to these drivers include, respectively, shifts in the timing and extent of freshwater inflow and salinity intrusion; decreasing turbidity; restructuring of plankton communities; nutrient enrichment; elimination of hypoxia and reduced metal contamination of biota; and food web changes that decrease resistance of the estuary to nutrient pollution. Detection of these changes and discovery of their causes through environmental monitoring have been essential for establishing and measuring outcomes of environmental policies that aim to maintain high water quality and sustain services provided by estuarine-coastal ecosystems. The wide range of variability time scales and the multiplicity of interacting drivers place heavy demands on estuarine monitoring programs. But the San Francisco Bay case study illustrates why the imperative for monitoring has never been greater.

  20. Failure of stop and go in de novo Parkinson's disease-a functional magnetic resonance imaging study

    NARCIS (Netherlands)

    Vriend, C.; Gerrits, N.J.H.M.; Berendse, H.W.; Veltman, D.J.; van den Heuvel, O.A.; van der Werf, Y.D.

    2015-01-01

    Behavioral impairments in response inhibition and initiation are common in Parkinson's disease (PD) and are associated with reduced impulse control. No prior study, however, has investigated the functional correlates of response inhibition in de novo PD. Twenty-one de novo PD patients and 37 matched