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Sample records for francisco novos alvos

  1. O CUSTEIO-ALVO COMO SUPORTE ÀS DECISÕES PARA DESENVOLVER NOVOS PRODUTOS: UM ESTUDO EM INDÚSTRIA MOVELEIRA

    Directory of Open Access Journals (Sweden)

    Romualdo Colauto

    2005-06-01

    Full Text Available O trabalho tem por objetivo apresentar a aplicação da metodologia do custeio-alvo como suporte à decisões de desenvolvimento de novos produtos em indústria moveleira. Os procedimentos metodológicos consistiram de uma pesquisa exploratória, realizada por meio de um estudo de caso, tendo uma empresa brasileira fabricante de móveis sob medida como sujeito d a pesquisa. Assim, inicia-se com uma breve incursão nos aspectos conceituais do target costing,  após contempla-se a abordagem da engenharia de valor, a seguir mostra-se a aplicação do custeio-alvo em uma indústria moveleira e apresenta-se as considerações finais do estudo. Os resultados da pesquisa evidenciam a viabilidade de aceitação de novo produto que atende às expectativas do cliente e ao mesmo tempo contemple o lucro operacional -meta estabelecido pela empresa.

  2. New molecular targets for PET and SPECT imaging in neurodegenerative diseases Novos alvos moleculares para tomografia por emissão de pósitrons (PET e tomografia computadorizada por emissão de fóton único (SPECT em doenças neurodegenerativas

    Directory of Open Access Journals (Sweden)

    Marcel Benadiba

    2012-10-01

    Full Text Available The pathophysiology of neurodegenerative diseases (ND such as Alzheimer's disease (AD and Parkinson's disease (PD has not yet been completely elucidated. However, in the past few years, there have been great knowledge advances about intra-and extracellular proteins that may display impaired function or expression in AD, PD and other ND, such as amyloid beta (Aβ, α-synuclein, tau protein and neuroinflammatory markers. Recent developments in the imaging techniques of positron emission tomography (PET and single photon emission computed tomography (SPECT now allow the non-invasive tracking of such molecular targets of known relevance to ND in vivo. This article summarizes recent findings of PET and SPECT studies using these novel methods, and discusses their potential role in the field of drug development for ND as well as future clinical applications in regard to differential diagnosis of ND and monitoring of disease progression.A fisiopatologia das doenças neurodegenerativas (DN, tais como a doença de Alzheimer (DA e a doença de Parkinson (DP, ainda não é completamente compreendida. No entanto, nos últimos anos, houve grandes avanços em termos do conhecimento sobre proteínas intra e extracelulares, tais como beta-amiloide (Aβ, α-sinucleína, proteína tau e marcadores neuroinflamatórios, que podem ter sua função ou expressão prejudicada na DA, DP ou em outras DN. Progressos recentes nas técnicas de tomografia por emissão de pósitrons (PET e tomografia computadorizada por emissão de fóton único (SPECT permitem hoje em dia a identificação não invasiva de tais alvos moleculares in vivo. Este artigo resume descobertas recentes de estudos de PET e SPECT cerebral usando esses alvos moleculares inovadores e discute o papel potencial dessas técnicas no campo do desenvolvimento de novos medicamentos para as DN, bem como futuras aplicações clínicas em relação ao diagnóstico diferencial e monitoramento da progressão dessas

  3. Kunstjäsemetega inimsööjad / Mart Kalvet, Alvo Aabloo, Kristjan Port

    Index Scriptorium Estoniae

    Kalvet, Mart, 1975-

    2011-01-01

    Inimene, meditsiin ja biotehnoloogia aastal 2031. Ennustavad tõlkija Mart Kalvet, Tartu Ülikooli arukate materjalide ja süsteemide labori professor Alvo Aabloo ja Tallinna Ülikooli Terviseteaduste ja Spordi Instituudi direktor Kristjan Port

  4. 3.3 Ga SHRIMP U-Pb zircon age of a felsic metavolcanic rock from the Mundo Novo greenstone belt in the São Francisco craton, Bahia (NE Brazil)

    Science.gov (United States)

    Peucat, J. J.; Mascarenhas, J. F.; Barbosa, J. S. F.; de Souza, S. L.; Marinho, M. M.; Fanning, C. M.; Leite, C. M. M.

    2002-07-01

    Felsic metavolcanics associated with supracrustal rocks provide U-Pb zircon and Sm-Nd TDM ages of approximately 3.3 Ga, which establish an Archean age of the Mundo Novo greenstone belt. A granodioritic gneiss from the Mairi complex, located on the eastern boundary of the Mundo Novo greenstone belt, exhibits a zircon evaporation minimum age of 3.04 Ga and a Nd model age of 3.2 Ga. These results constrain the occurrence of at least three major geological units in this area: the Archean Mundo Novo greenstone belt, the Archean Mairi gneisses, and the adjoining Paleoproterozoic (<2.1 Ga) Jacobina sedimentary basin. The Jacobina basin follows the same trend as the Archean structure, extending southward to the Contendas-Mirante belt, in which a similar Archean-Paleoproterozoic association appears. We postulate that during the Paleoproterozoic in the eastern margin of the Gavião block, these Archean greenstone belts constituted a zone of weakness along which a late-stage orogenic sedimentary basin developed.

  5. Reassessment of the geologic evolution of selected precambrian terranes in Brazil, based on SHRIMP U-Pb data, part 2: mineiro and Aracuai orogens and Southern Sao Francisco craton; Reavaliacao da evolucao geologica em terrenos pre-cambrianos brasileiros com base em novos dados U-Pb SHRIMP, parte 2: orogeno Aracuai, cinturao mineiro e craton Sao Francisco Meridional

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Luiz Carlos da; Pimentel, Marcio [Brasilia Univ., DF (Brazil). Inst. de Geociencias]. E-mail: luizcarlos@aneel.gov.br; Leite, Carlos Augusto; Vieira, Valter Salino; Silva, Marcio Antonio da; Paes, Vinicius Jose de Castro; Cardoso Filho, Joao Moraes [Companhia de Pesquisas de Recursos Minerais (CPRM), Belo Horizonte, MG (Brazil); Armstrong, Richard [Australian National Univ., Canberra (Australia). Research School of Earth Sciences; Noce, Carlos Mauricio; Pedrosa-Soares, Antonio Carlos [Minas Gerais Univ., Belo Horizonte (Brazil). Inst. de Geociencias. Centro de Pesquisa Manuel Teixeira da Costa; Carneiro, Mauricio Antonio [Ouro Preto Univ., MG (Brazil). Dept. de Geologia

    2002-12-15

    This paper discusses new zircon SHRIMP (Sensitive High Resolution Ion Microprobe) U-Pb geochronological data for 19 key-exposures of several geological units exposed at the eastern border of the Southern Sao Francisco Craton and at the adjacent Proterozoic Mineiro and Aracuai orogens. Samples were collected along several E-W tran sects, aiming at tracing the precise limit of the Sao Francisco Craton Archean basement, as well as assessing the extension of the successive proterozoic orogenic collages. Due to the complex geologic history and/or high grade metamorphism which most of the rock units investigated have undergone, zircon morphology and the U-Pb analytical data exhibit very complex patterns. These are characterized by a combination of inheritance, partial resetting and new zircon growth during high-grade metamorphism. As a consequence, very careful and detailed analyses of cathodoluminescence imagery were required to allow distinction between inheritance, newly melt-precipitated zircon and partially reset zircons, as well as between the ages of magmatic and metamorphic events. In the southeastern border of the craton 5 units yielded Archean crystallization ages ranging from ca. 3000-2700 Ma, with poorly constrained metamorphic ages ranging from ca. 2850 to 550 Ma. The TTG gneissic complex exposed to the east and south of the Quadrilatero Ferrifero, formerly ascribed to the Archean basement, have crystallization ages from ca. 2210 Ma to 2050 Ma, and can now be interpreted as representing pre- to syn-collisional magmatic phases of the Mineiro Belt. Metamorphic ages of ca. 2100 Ma and 560 Ma are also well constrained in zircon populations from these gneisses. The crystallization age of ca 1740 Ma observed for an alkaline granite of the Borrachudos Suite (intrusive into the Archean basement east of the Southern Espinhaco Range) confirmed previous conventional U-Pb data for this Paleoproterozoic rift-related magmatism. One of the major basement inliers within the

  6. San Francisco Accelerator Conference

    International Nuclear Information System (INIS)

    Southworth, Brian

    1991-01-01

    'Where are today's challenges in accelerator physics?' was the theme of the open session at the San Francisco meeting, the largest ever gathering of accelerator physicists and engineers

  7. Fusões e aquisições : influências da competição na avaliação da empresa alvo

    OpenAIRE

    Anselmo Filho, Fernando Antonio Fernandes

    2016-01-01

    Este trabalho analisou os fatores que importam na estimação do prêmio ofertado à empresa alvo. Ao mesmo tempo que analisou a competição no mercado corporativo, entendido como um fator exógeno à empresa alvo, avaliou condições internas à empresa alvo, como por exemplo seu endividamento, entendido como fator endógeno. A literatura sobre aquisição hostil tem substancialmente avançado, mas ainda existe interesse crescente em pesquisar o processo de aquisição hostil do lance inicial até o resultad...

  8. Uso de Diferentes Sensores de Satélite na Discriminação de Alvos Naturais

    Directory of Open Access Journals (Sweden)

    Gustavo Ferreira de Souza

    2016-01-01

    Full Text Available As particularidades nos instrumentos de sensoriamento remoto, mesmo quando possuem características semelhantes, torna as imagens geradas por estes, diferentes entre si. Visando isto, o objetivo do trabalho foi analisar a aplicabilidade e os limites de detecção na identificação de alvos naturais em diferentes imagens de satélites. A área de estudo está localizada no Estado de São Paulo dentro do Município de Onda Verde, os alvos naturais foram selecionados a partir de análises realizadas nas imagens e visita desses pontos em campo. Foram escolhidas áreas que apresentaram bom contraste com o entorno e fácil localização nas imagens de satélite. Para o processamento digital de imagem foi utilizado o software livre gvSIG. Neste estudo foram empregados dados de satélites de média resolução espacial como Landsat-5, CBERS-2B e IRS-P6, disponíveis na base de dados de domínio público do INPE (Instituto Nacional de Pesquisas Espaciais e imagens de alta resolução espacial dos satélites RapidEye e WorldView-2. Nos sensores de média resolução espacial, as menores resoluções espaciais dos sensores TM e LISS-3, não impediram a visualização dos alvos espectrais analisados, visto que, no CCD que possui uma maior resolução espacial, não foi possível a identificação dos alvos escolhidos. As imagens de alta resolução espacial RapidEye e WorldView apresentaram grande riqueza de detalhamento para a cobertura do solo, a isto atrela-se a alta resolução radiométrica desses satélites.

  9. Percepção de Valor e Custeio Alvo: Um Estudo no Segmento de Móveis Planejados

    OpenAIRE

    Bruni, Adriano Leal; Carvalho Júnior, César Valentim de Oliveira; Figueiredo, Moreno; Paixão, Roberto Brazileiro; Silva Júnior, José Valdir Garcia da

    2008-01-01

    p. 35 - 49 O presente trabalho buscou estudar uma empresa do ramo de móveis planejados com o objetivo de determinar os atributos de valor e o custo alvo da mesma. O estudo de caso foi efetuado na empresa Top Lar, Projetos & Decoração, localizada no bairro da Calçada, Salvador, Bahia. Para atingir aos objetivos de pesquisa propostos, foram utilizados como instrumentos de coleta de dados um questionário e um roteiro de entrevistas para identificação dos atributos de valor atri...

  10. UTILIZAÇÃO DE ALVOS CODIFICADOS DO TIPO ARUCO NA AUTOMAÇÃO DO PROCESSO DE CALIBRAÇÃO DE CÂMARAS

    Directory of Open Access Journals (Sweden)

    Sérgio Leandro Alves da Silva

    Full Text Available Este trabalho apresenta uma proposta para a automatização do processo de calibração de câmaras usando a localização e medição de pontos em alvos codificados, com precisão subpixel, o que contribui para minimizar os erros de localização, independente da orientação da câmara e da escala da imagem. Para alcançar este objetivo foram analisados os alvos codificados mais relevantes na literatura, sendo escolhido o padrão ARUCO, devido à sua flexibilidade, capacidade para representar até 1.024 alvos diferentes e disponibilidade de código fonte, implementado com a biblioteca OpenCV, que garante simplicidade de implementação e alta confiabilidade. Após a geração dos alvos com o padrão ARUCO, foram criados os painéis usados para a aquisição das imagens empregadas na calibração da câmara. O programa desenvolvido foi usado para localizar os alvos nas imagens e extrair automaticamente as coordenadas dos quatro cantos, com precisão subpixel. Os experimentos realizados mostraram que a maioria dos alvos foi identificada corretamente. Os resultados do experimento com a calibração de uma câmara de baixo custo mostraram que o processo funciona e que a precisão das medidas dos cantos atinge o nível subpixel.

  11. San Francisco Bay Water Quality Improvement Fund

    Science.gov (United States)

    EPAs grant program to protect and restore San Francisco Bay. The San Francisco Bay Water Quality Improvement Fund (SFBWQIF) has invested in 58 projects along with 70 partners contributing to restore wetlands, water quality, and reduce polluted runoff.,

  12. Marketing político : os jovens e as oportunidades trazidas pelos novos meios de comunicação

    OpenAIRE

    Ferreira, Teresa Sande e Castro Pinto

    2012-01-01

    Mestrado em Ciências Empresariais Os novos meios de comunicação digitais vieram revolucionar o marketing e a comunicação na esfera política, criando novas oportunidades a nível do envolvimento com os eleitores, sobretudo pela interactividade que possibilitam. Nesta nova era, os jovens, nascidos do seio destas tecnologias, apresentam-se como alvos bastante apetecíveis das novas formas de comunicar. Este estudo de caso comparativo foi desenvolvido com o intuito de compreender de que forma es...

  13. Taevasse kosmoseliftiga / Alvo Aabloo

    Index Scriptorium Estoniae

    Aabloo, Alvo, 1965-

    2007-01-01

    MTÜ Spaceward Foundation on algatanud projekti Elevator 2010. Tegemist on viieaastase võistlusega, mille käigus loodetakse välja arendada peamised tehnoloogiad, mis on vajalikud kosmoselifti ehitamiseks

  14. ASTER Flyby of San Francisco

    Science.gov (United States)

    2002-01-01

    The Advanced Spaceborne Thermal Emission and Reflection radiometer, ASTER, is an international project: the instrument was supplied by Japan's Ministry of International Trade and Industry. A joint US/Japan science team developed algorithms for science data products, and is validating instrument performance. With its 14 spectral bands, extremely high spatial resolution, and 15 meter along-track stereo capability, ASTER is the zoom lens of the Terra satellite. The primary mission goals are to characterize the Earth's surface; and to monitor dynamic events and processes that influence habitability at human scales. ASTER's monitoring and mapping capabilities are illustrated by this series of images of the San Francisco area. The visible and near infrared image reveals suspended sediment in the bays, vegetation health, and details of the urban environment. Flying over San Francisco (3.2MB) (high-res (18.3MB)), we see the downtown, and shadows of the large buildings. Past the Golden Gate Bridge and Alcatraz Island, we cross San Pablo Bay and enter Suisun Bay. Turning south, we fly over the Berkeley and Oakland Hills. Large salt evaporation ponds come into view at the south end of San Francisco Bay. We turn northward, and approach San Francisco Airport. Rather than landing and ending our flight, we see this is as only the beginning of a 6 year mission to better understand the habitability of the world on which we live. For more information: ASTER images through Visible Earth ASTER Web Site Image courtesy of MITI, ERSDAC, JAROS, and the U.S./Japan ASTER Science Team

  15. A presença do Novo Mundo na iconografia da morte e dos sonhos de São Francisco Xavier: a missão jesuítica e as partes e gentes do Império Português

    Directory of Open Access Journals (Sweden)

    Luís Filipe Silvério Lima

    2014-08-01

    Full Text Available A proposta deste artigo é analisar diferentes leituras pictóricas da morte e dos sonhos de S. Francisco Xavier, desde inícios do século XVII até a parte da pesquisa em relação à morte deriva de monografia defendida em 2010 na Unifesp. Versões da parte sobre o sonho foram apresentadas em congressos em 2010 e uma prévia bastante resumida foi publicada na Revista de História da Biblioteca Nacional (n. 93, Junho de 2013. Gostaríamos de agradecer às contribuições feitas naquelas ocasiões pela audiência e pela banca, bem como também agradecemos a André Tavares, Evergton Sales Souza, Renato Cymbalista e aos pareceristas. A pesquisa contou com o apoio do CNPq e da Fapesp. meados do século XVIII. Se o jesuíta, mesmo antes de sua canonização em 1622 era entendido como Apóstolo do Oriente, a partir da segunda metade do século XVII, ocorreu uma mudança iconográfica pela qual aos personagens e elementos asiáticos somaram-se africanos e índios americanos na representação da cena de sua morte e de seus sonhos. Pretende-se a partir desse câmbio imagético analisar a construção de um programa visual da hagiografia de Xavier, no qual a vinculação exclusiva com o Oriente é suplantada pelos esforços em caracterizá-lo como exemplo máximo para a Missão, aplicável também - e sobretudo - às Américas. Interessam aqui em particular essas modulações no caso do Brasil e do Império Português.

  16. Trouble Brewing in San Francisco. Policy Brief

    Science.gov (United States)

    Buck, Stuart

    2010-01-01

    The city of San Francisco will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that San Francisco faces an aggregate $22.4 billion liability for pensions and retiree health benefits that are underfunded--including $14.1 billion for the city…

  17. Influência do nível de desempenho de jogadores de badminton em aspectos neuromotores durante uma tarefa de apontar um alvo

    Directory of Open Access Journals (Sweden)

    Luiz de França Bahia Loureiro Jr.

    2012-06-01

    Full Text Available O badminton é um esporte no qual os atletas devem responder a golpes rápidos e potentes de maneira acurada. Assim, o objetivo do estudo foi investigar se jogadores de badminton de alto nível apresentam melhores índices de desempenho neuromuscular do que jogadores de nível intermediário na tarefa de apontar um alvo. Doze jogadores de alto nível (GAN, que defendem ou defenderam a seleção brasileira de badminton, e 12 jogadores de nível intermediário (GNI participaram do estudo. Eles permaneceram em pé, com o dedo indicador da mão dominante sobre um interruptor localizado à frente e direcionado à linha média do corpo, e foram instruídos a tocar um alvo em uma tela sensível ao toque posicionada à frente assim que ele se tornasse luminoso. O alvo foi apresentado ipsilateralmente ou contralateralmente ao membro superior dominante, em blocos (tempo de reação simples ou randomicamente (tempo de reação de escolha. As variáveis tempo de reação (TR, tempo de movimento (TM e erro radial (ER foram computadas. Os resultados não revelaram efeito de grupo para TM e ER, mas revelaram que o GAN apresentou TR menor que o GNI. Ainda, o TR foi menor para a condição em blocos e o TR e o TM foram menores para o alvo ipsilateral. O fato de o GAN apresentar TR menor que o GNI indica que jogadores de alto nível teriam melhor capacidade reativa que jogadores de níveis inferiores. Assim, concluímos que o TR poderia ser uma variável importante na seleção de atletas que teriam maiores chances de alcançar altos níveis de desempenho no badminton. Ainda, apesar de o teste utilizado não representar integralmente as ações de jogo, ele é um avanço quando comparado aos testes comumente utilizados na investigação do TR e TM em atletas e deveria ser utilizado na avaliação de atletas de outros esportes.

  18. De Novo Glutamine Synthesis

    Science.gov (United States)

    He, Qiao; Shi, Xinchong; Zhang, Linqi; Yi, Chang; Zhang, Xuezhen

    2016-01-01

    Purpose: The aim of this study was to investigate the role of de novo glutamine (Gln) synthesis in the proliferation of C6 glioma cells and its detection with 13N-ammonia. Methods: Chronic Gln-deprived C6 glioma (0.06C6) cells were established. The proliferation rates of C6 and 0.06C6 cells were measured under the conditions of Gln deprivation along with or without the addition of ammonia or glutamine synthetase (GS) inhibitor. 13N-ammonia uptake was assessed in C6 cells by gamma counting and in rats with C6 and 0.06C6 xenografts by micro–positron emission tomography (PET) scanning. The expression of GS in C6 cells and xenografts was assessed by Western blotting and immunohistochemistry, respectively. Results: The Gln-deprived C6 cells showed decreased proliferation ability but had a significant increase in GS expression. Furthermore, we found that low concentration of ammonia was sufficient to maintain the proliferation of Gln-deprived C6 cells, and 13N-ammonia uptake in C6 cells showed Gln-dependent decrease, whereas inhibition of GS markedly reduced the proliferation of C6 cells as well as the uptake of 13N-ammoina. Additionally, microPET/computed tomography exhibited that subcutaneous 0.06C6 xenografts had higher 13N-ammonia uptake and GS expression in contrast to C6 xenografts. Conclusion: De novo Gln synthesis through ammonia–glutamate reaction plays an important role in the proliferation of C6 cells. 13N-ammonia can be a potential metabolic PET tracer for Gln-dependent tumors. PMID:27118759

  19. 76 FR 22809 - Safety Zone; Bay Ferry II Maritime Security Exercise; San Francisco Bay, San Francisco, CA

    Science.gov (United States)

    2011-04-25

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2011-0196] RIN 1625-AA00 Safety Zone; Bay Ferry II Maritime Security Exercise; San Francisco Bay, San Francisco, CA AGENCY... Security Exercise; San Francisco Bay, San Francisco, CA. (a) Location. The limits of this safety zone...

  20. San Francisco Bay Interferometric Bathymetry: Area B

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — High resolution sonar data were collected over ultra-shallow areas of the San Francisco Bay estuary system. Bathymetric and acoustic backscatter data were collected...

  1. April 1906 San Francisco, USA Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1906 San Francisco earthquake was the largest event (magnitude 8.3) to occur in the conterminous United States in the 20th Century. Recent estimates indicate...

  2. Toxic phytoplankton in San Francisco Bay

    Science.gov (United States)

    Rodgers, Kristine M.; Garrison, David L.; Cloern, James E.

    1996-01-01

    The Regional Monitoring Program (RMP) was conceived and designed to document the changing distribution and effects of trace substances in San Francisco Bay, with focus on toxic contaminants that have become enriched by human inputs. However, coastal ecosystems like San Francisco Bay also have potential sources of naturally-produced toxic substances that can disrupt food webs and, under extreme circumstances, become threats to public health. The most prevalent source of natural toxins is from blooms of algal species that can synthesize metabolites that are toxic to invertebrates or vertebrates. Although San Francisco Bay is nutrient-rich, it has so far apparently been immune from the epidemic of harmful algal blooms in the world’s nutrient-enriched coastal waters. This absence of acute harmful blooms does not imply that San Francisco Bay has unique features that preclude toxic blooms. No sampling program has been implemented to document the occurrence of toxin-producing algae in San Francisco Bay, so it is difficult to judge the likelihood of such events in the future. This issue is directly relevant to the goals of RMP because harmful species of phytoplankton have the potential to disrupt ecosystem processes that support animal populations, cause severe illness or death in humans, and confound the outcomes of toxicity bioassays such as those included in the RMP. Our purpose here is to utilize existing data on the phytoplankton community of San Francisco Bay to provide a provisional statement about the occurrence, distribution, and potential threats of harmful algae in this Estuary.

  3. San Francisco folio, California, Tamalpais, San Francisco, Concord, San Mateo, and Haywards quadrangles

    Science.gov (United States)

    Lawson, Andrew Cowper

    1914-01-01

    The five sheets of the San Francisco folio the Tamalpais, Ban Francisco, Concord, Ban Mateo, and Haywards sheets map a territory lying between latitude 37° 30' and 38° and longitude 122° and 122° 45'. Large parts of four of these sheets cover the waters of the Bay of San Francisco or of the adjacent Pacific Ocean. (See fig. 1.) Within the area mapped are the cities of San Francisco, Oakland, Berkeley, Alameda, Ban Rafael, and San Mateo, and many smaller towns and villages. These cities, which have a population aggregating about 750,000, together form the largest and most important center of commercial and industrial activity on the west coast of the United States. The natural advantages afforded by a great harbor, where the railways from the east meet the ships from all ports of the world, have determined the site of a flourishing cosmopolitan, commercial city on the shores of San Francisco Bay. The bay is encircled by hilly and mountainous country diversified by fertile valley lands and divides the territory mapped into two rather contrasted parts, the western part being again divided by the Golden Gate. It will therefore be convenient to sketch the geographic features under four headings (1) the area east of San Francisco Bay; (2) the San Francisco Peninsula; (3) the Marin Peninsula; (4) San Francisco Bay. (See fig. 2.)

  4. 78 FR 57482 - Safety Zone; America's Cup Aerobatic Box, San Francisco Bay, San Francisco, CA

    Science.gov (United States)

    2013-09-19

    ...-AA00 Safety Zone; America's Cup Aerobatic Box, San Francisco Bay, San Francisco, CA AGENCY: Coast Guard... America's Cup air shows. These safety zones are established to provide a clear area on the water for... announced by America's Cup Race Management. ADDRESSES: Documents mentioned in this preamble are part of...

  5. 78 FR 34123 - Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA

    Science.gov (United States)

    2013-06-06

    ... completion of an inventory of human remains and associated funerary objects under the control of the San....R50000] Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA... NAGPRA Program has completed an inventory of human remains and associated funerary objects, in...

  6. 78 FR 21403 - Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA

    Science.gov (United States)

    2013-04-10

    ... completion of an inventory of human remains and associated funerary objects under the control of the San....R50000] Notice of Inventory Completion: San Francisco State University NAGPRA Program, San Francisco, CA... NAGPRA Program has completed an inventory of human remains and associated funerary objects, in...

  7. 75 FR 27432 - Security Zone; Golden Guardian 2010 Regional Exercise; San Francisco Bay, San Francisco, CA

    Science.gov (United States)

    2010-05-17

    ... can better evaluate its effects on them and participate in the rulemaking process. Small businesses... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2010-0221] RIN 1625-AA87 Security Zone; Golden Guardian 2010 Regional Exercise; San Francisco Bay, San Francisco, CA AGENCY...

  8. Statistical treatment of geochemical data and its application in the geologic mapping and in the definition of the geochemical anomalies in the Alvo 2-Corpo 4 -Provincia Mineral de Carajas

    International Nuclear Information System (INIS)

    Moura, C.A.V.

    1982-01-01

    It was given a statistical treatment for the geochemical data about soil in the are named Alvo2 - Corpo4- in the Provincia Mineral de Carajas, Para, Brazil, for application of the geological mapping and definition of geochemical anomalies. (A.B.) [pt

  9. San Francisco Bay Long Term Management Strategy for Dredging

    Science.gov (United States)

    The San Francisco Bay Long Term Management Strategy (LTMS) is a cooperative effort to develop a new approach to dredging and dredged material disposal in the San Francisco Bay area. The LTMS serves as the Regional Dredging Team for the San Francisco area.

  10. Pesquisa de novos elementos Pesquisa de novos elementos

    Directory of Open Access Journals (Sweden)

    Gil Mário de Macedo Grassi

    1978-11-01

    Full Text Available The present study deals with the discovery of new elements synthesized by man. The introduction discusses in general the theories about nuclear transmutation, which is the method employed in these syntheses. The study shows the importance of the Periodical Table since it is through this table that one can reach a prevision of new elements and its, properties. The discoveries of the transuranic elements, together wich the data of their first preparations are also tabulated The stability of these elements is also discussed, and future speculations are showedNeste trabalho estuda-se, teoricamente, a descoberta de novos elementos sintetizados pelo homem Na introdução apresentamos um apanhado geral sobre as teorias a respeito da transmutação nuclear, que é o método utilizado nestas sínteses. Em seguida, mostramos a importância da Tabela Periódica, pois é através dela que se chega à previsão dos novos elementos e de suas propriedades. As descobertas dos transurânicos, Já realizadas com êxito, juntamente com os dados de suas primeiras preparações são tabelados. A estabilidade destes novos elementos também é discutida, e apresentadas futuras especulações.

  11. Recentes avanços da quimioterapia das leishmanioses: moléculas intracelulares como alvo de fármacos Recent advances on leishmaniasis chemotherapy: intracelular molecules as a drug target

    Directory of Open Access Journals (Sweden)

    Rômulo José Soares-Bezerra

    2004-06-01

    Full Text Available Leishmanioses são doenças causadas por protozoários do gênero Leishmania sp., que se apresentam na forma promastigota ou amastigota; os promastigotas infectam o inseto vetor e os amastigotas são as formas infectivas antes presentes em macrófagos humanos. O tratamento utilizado pela clínica tem se mostrado ineficaz; os fármacos utilizados se apresentam na forma injetável, o que dificulta o tratamento, já que o paciente, para ser tratado, deve ser internado para as aplicações - que são dolorosas - e assim muitos pacientes desistem do tratamento. Outra razão para a internação é a monitoração dos efeitos colaterais causados pelos fármacos. Por estas razões a quimioterapia para leishmaniose tem sido objeto de estudo de muitos laboratórios de pesquisa, os quais têm testado outras substâncias químicas e extratos de plantas com a finalidade de se encontrar novos agentes leishmanicidas com menores efeitos colaterais e ótima biodisponibilidade. Além disso, pesquisam-se, também, outras formas farmacêuticas que viabilizem a aplicação desses fármacos, o que tornaria desnecessária a internação do paciente para se efetuar o tratamento. Este artigo visa discutir os recentes avanços da quimioterapia utilizada para as leishmanioses e, também, apresentar os aspectos farmacológicos e bioquímicos da participação de moléculas intracelulares do parasita como alvos de fármacos.The leishmaniases are diseases caused by protozoan parasites Leishmania sp., that are present in promastigotes or amastigotes forms; the promastigotes infect the sand fly vector, and the amastigotes are the infective forms presented on human macrophages. These protozooses showed two types of clinical manifestations: tegumentar and visceral. The clinical treatments used have shown inefficient; the drugs utilized are presented in injectable form, difficulting the treatment, since to be the patient, may be interned for applications, which are painful

  12. Plantas transgênicas resistentes a insetos e organismos não-alvo: predadores, parasitóides e polinizadores - doi: 10.5102/ucs.v4i1.23

    Directory of Open Access Journals (Sweden)

    Marina Regina Frizzas

    2008-04-01

    Full Text Available Plantas geneticamente modificadas resistentes aos insetos oferecem benefícios à agricultura moderna. No entanto, esta tecnologia pode afetar o controle biológico natural e a biodiversidade por meio de efeitos diretos e indiretos das plantas transgênicas sobre o valor adaptativo e comportamental de predadores, parasitóides, polinizadores e outros artrópodes não-alvo. Neste artigo, são discutidos os impactos ou os efeitos potenciais de plantas transgênicas resistentes a insetos sobre organismos não-alvo, com ênfase em artrópodes predadores, parasitóides e polinizadores, e os principais estudos com plantas transgênicas resistentes a insetos, publicados nos últimos dez anos.

  13. Agriculture, Rio Sao Francisco, Brazil, South America

    Science.gov (United States)

    1988-01-01

    The large field patterns in this view of the Rio Sao Francisco basin, Brazil, South America, (11.5S, 43.5W) indicate a commercial agriculture venture; family subsistence farms are much smaller and laid out in different patterns. Land clearing in Brazil has increased at an alarming rate in recent years and preliminary estimates suggest a 25 to 30% increase in deforestation since 1984. The long term impact on the ecological processes are still unknown.

  14. An overview of San Francisco Bay PORTS

    Science.gov (United States)

    Cheng, Ralph T.; McKinnie, David; English, Chad; Smith, Richard E.

    1998-01-01

    The Physical Oceanographic Real-Time System (PORTS) provides observations of tides, tidal currents, and meteorological conditions in real-time. The San Francisco Bay PORTS (SFPORTS) is a decision support system to facilitate safe and efficient maritime commerce. In addition to real-time observations, SFPORTS includes a nowcast numerical model forming a San Francisco Bay marine nowcast system. SFPORTS data and nowcast numerical model results are made available to users through the World Wide Web (WWW). A brief overview of SFPORTS is presented, from the data flow originated at instrument sensors to final results delivered to end users on the WWW. A user-friendly interface for SFPORTS has been designed and implemented. Appropriate field data analysis, nowcast procedures, design and generation of graphics for WWW display of field data and nowcast results are presented and discussed. Furthermore, SFPORTS is designed to support hazardous materials spill prevention and response, and to serve as resources to scientists studying the health of San Francisco Bay ecosystem. The success (or failure) of the SFPORTS to serve the intended user community is determined by the effectiveness of the user interface.

  15. City of San Francisco, California street tree resource analysis

    Science.gov (United States)

    E.G. McPherson; J.R. Simpson; P.J. Peper; Q. Xiao

    2004-01-01

    Street trees in San Francisco are comprised of two distinct populations, those managed by the city’s Department of Public Works (DPW) and those managed by private property owners with or without the help of San Francisco’s urban forestry nonprofit, Friends of the Urban Forest (FUF). These two entities believe that the public’s investment in stewardship of San Francisco...

  16. A Public Trial De Novo

    DEFF Research Database (Denmark)

    Vedel, Jane Bjørn; Gad, Christopher

    2011-01-01

    This article addresses the concept of “industrial interests” and examines its role in a topical controversy about a large research grant from a private foundation, the Novo Nordisk Foundation, to the University of Copenhagen. The authors suggest that the debate took the form of a “public trial” w.......” The article ends with a discussion of some implications of the analysis, including that policy making, academic research, and public debates might benefit from more detailed accounts of interests and stakes.......This article addresses the concept of “industrial interests” and examines its role in a topical controversy about a large research grant from a private foundation, the Novo Nordisk Foundation, to the University of Copenhagen. The authors suggest that the debate took the form of a “public trial......” where the grant and close(r) intermingling between industry and public research was prosecuted and defended. First, the authors address how the grant was framed in the media. Second, they redescribe the case by introducing new “evidence” that, because of this framing, did not reach “the court...

  17. de novo computational enzyme design.

    Science.gov (United States)

    Zanghellini, Alexandre

    2014-10-01

    Recent advances in systems and synthetic biology as well as metabolic engineering are poised to transform industrial biotechnology by allowing us to design cell factories for the sustainable production of valuable fuels and chemicals. To deliver on their promises, such cell factories, as much as their brick-and-mortar counterparts, will require appropriate catalysts, especially for classes of reactions that are not known to be catalyzed by enzymes in natural organisms. A recently developed methodology, de novo computational enzyme design can be used to create enzymes catalyzing novel reactions. Here we review the different classes of chemical reactions for which active protein catalysts have been designed as well as the results of detailed biochemical and structural characterization studies. We also discuss how combining de novo computational enzyme design with more traditional protein engineering techniques can alleviate the shortcomings of state-of-the-art computational design techniques and create novel enzymes with catalytic proficiencies on par with natural enzymes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Public Involvement and Response Plan (Community Relations Plan), Presidio of San Francisco, San Francisco, California

    Science.gov (United States)

    1992-03-01

    passenger ship destination, and tourist attraction. San Francisco’s location and cultural and recreational opportunities make it a prime tourism center...equestrians, she said. C-52 m% smm : - TUESDAY, JUNE 19,1990 * . COPYKIGHT 1*90/THE TIMES MlRkOX COMPANY /CC/1 JO PAGES P. A-l, 22, 23 Complex

  19. 75 FR 39166 - Safety Zone; San Francisco Giants Baseball Game Promotion, San Francisco, CA

    Science.gov (United States)

    2010-07-08

    ... San Francisco, CA. The fireworks display is meant for entertainment purposes. This safety zone is... National Technology Transfer and Advancement Act (NTTAA) (15 U.S.C. 272 note) directs agencies to use...), of the Instruction. This rule involves establishing, disestablishing, or changing Regulated...

  20. UniNovo: a universal tool for de novo peptide sequencing.

    Science.gov (United States)

    Jeong, Kyowon; Kim, Sangtae; Pevzner, Pavel A

    2013-08-15

    Mass spectrometry (MS) instruments and experimental protocols are rapidly advancing, but de novo peptide sequencing algorithms to analyze tandem mass (MS/MS) spectra are lagging behind. Although existing de novo sequencing tools perform well on certain types of spectra [e.g. Collision Induced Dissociation (CID) spectra of tryptic peptides], their performance often deteriorates on other types of spectra, such as Electron Transfer Dissociation (ETD), Higher-energy Collisional Dissociation (HCD) spectra or spectra of non-tryptic digests. Thus, rather than developing a new algorithm for each type of spectra, we develop a universal de novo sequencing algorithm called UniNovo that works well for all types of spectra or even for spectral pairs (e.g. CID/ETD spectral pairs). UniNovo uses an improved scoring function that captures the dependences between different ion types, where such dependencies are learned automatically using a modified offset frequency function. The performance of UniNovo is compared with PepNovo+, PEAKS and pNovo using various types of spectra. The results show that the performance of UniNovo is superior to other tools for ETD spectra and superior or comparable with others for CID and HCD spectra. UniNovo also estimates the probability that each reported reconstruction is correct, using simple statistics that are readily obtained from a small training dataset. We demonstrate that the estimation is accurate for all tested types of spectra (including CID, HCD, ETD, CID/ETD and HCD/ETD spectra of trypsin, LysC or AspN digested peptides). UniNovo is implemented in JAVA and tested on Windows, Ubuntu and OS X machines. UniNovo is available at http://proteomics.ucsd.edu/Software/UniNovo.html along with the manual.

  1. Evolução dos padrões fundamentais de movimento arremessar ( a distância e ao alvo) e correr em pessoas portadoras de deficiência mental

    OpenAIRE

    Junghahnel, Verena

    2013-01-01

    Este estudo teve por objetivo investigar mudanças no comportamento motor de pessoas portadoras de deficiência mental leve, moderada e severa, em relação aos padrões fundamentais de movimento arremessar (à distancia e ao alvo) e correr. Participaram deste estudo 51 jeitos, na faixa etária de 231 8 a 13 anos, alunos do setor educacional do centro de habilitação da apae de São Paulo. As execuções (5 para da tipo de arremesso e 4 para a corrida) foram registradas em vídeo cassete e o...

  2. Microbial biogeography of San Francisco Bay sediments

    Science.gov (United States)

    Lee, J. A.; Francis, C. A.

    2014-12-01

    The largest estuary on the west coast of North America, San Francisco Bay is an ecosystem of enormous biodiversity, and also enormous human impact. The benthos has experienced dredging, occupation by invasive species, and over a century of sediment input as a result of hydraulic mining. Although the Bay's great cultural and ecological importance has inspired numerous surveys of the benthic macrofauna, to date there has been almost no investigation of the microbial communities on the Bay floor. An understanding of those microbial communities would contribute significantly to our understanding of both the biogeochemical processes (which are driven by the microbiota) and the physical processes (which contribute to microbial distributions) in the Bay. Here, we present the first broad survey of bacterial and archaeal taxa in the sediments of the San Francisco Bay. We conducted 16S rRNA community sequencing of bacteria and archaea in sediment samples taken bimonthly for one year, from five sites spanning the salinity gradient between Suisun and Central Bay, in order to capture the effect of both spatial and temporal environmental variation on microbial diversity. From the same samples we also conducted deep sequencing of a nitrogen-cycling functional gene, nirS, allowing an assessment of evolutionary diversity at a much finer taxonomic scale within an important and widespread functional group of bacteria. We paired these sequencing projects with extensive geochemical metadata as well as information about macrofaunal distribution. Our data reveal a diversity of distinct biogeographical patterns among different taxa: clades ubiquitous across sites; clades that respond to measurable environmental drivers; and clades that show geographical site-specificity. These community datasets allow us to test the hypothesis that salinity is a major driver of both overall microbial community structure and community structure of the denitrifying bacteria specifically; and to assess

  3. Shaded Relief of Rio Sao Francisco, Brazil

    Science.gov (United States)

    2000-01-01

    This topographic image acquired by SRTM shows an area south of the Sao Francisco River in Brazil. The scrub forest terrain shows relief of about 400 meters (1300 feet). Areas such as these are difficult to map by traditional methods because of frequent cloud cover and local inaccessibility. This region has little topographic relief, but even subtle changes in topography have far-reaching effects on regional ecosystems. The image covers an area of 57 km x 79 km and represents one quarter of the 225 km SRTM swath. Colors range from dark blue at water level to white and brown at hill tops. The terrain features that are clearly visible in this image include tributaries of the Sao Francisco, the dark-blue branch-like features visible from top right to bottom left, and on the left edge of the image, and hills rising up from the valley floor. The San Francisco River is a major source of water for irrigation and hydroelectric power. Mapping such regions will allow scientists to better understand the relationships between flooding cycles, forestation and human influences on ecosystems.This shaded relief image was generated using topographic data from the Shuttle Radar Topography Mission. A computer-generated artificial light source illuminates the elevation data to produce a pattern of light and shadows. Slopes facing the light appear bright, while those facing away are shaded. On flatter surfaces, the pattern of light and shadows can reveal subtle features in the terrain. Shaded relief maps are commonly used in applications such as geologic mapping and land use planning.The Shuttle Radar Topography Mission (SRTM), launched on February 11, 2000, uses the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. The mission is designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200

  4. Enhanced Preliminary Assessment Report: Presidio of San Francisco Military Reservation, San Francisco, California

    Science.gov (United States)

    1989-11-01

    CAD981415656 Filmore Steiner Bay San Francisco 24 PG&E Gas Plant SanFran 502-IG CAD981415714 Bay North Point Buchanan Laguna 25 PG&E Gas Plant SanFran 502-1H...76-ioV /5,JO /0.7 /,230 PSF Water PSF, Main U.N. Lagunda Honda Analvte Plant Clearwell Reservoir Plaza Reservoi- Chlordane inetab. ə.2 ə.2 (1.2 ə.2

  5. 77 FR 60897 - Safety Zone: America's Cup World Series Finish-Line, San Francisco, CA

    Science.gov (United States)

    2012-10-05

    ... navigable waters of the San Francisco Bay in vicinity of San Francisco West Yacht Harbor Light 2... vicinity of San Francisco West Yacht Harbor Light 2. Unauthorized persons or vessels are prohibited from... San Francisco West Yacht Harbor Light 2. This safety zone establishes a temporary restricted area on...

  6. 75 FR 65985 - Safety Zone: Epic Roasthouse Private Party Firework Display, San Francisco, CA

    Science.gov (United States)

    2010-10-27

    ... the navigable waters of San Francisco Bay 1,000 yards off Epic Roasthouse Restaurant, San Francisco.... Wright, Program Manager, Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: Regulatory... waters of San Francisco Bay, 1,000 yards off Epic Roasthouse Restaurant, San Francisco, CA. The fireworks...

  7. Developing solar power programs : San Francisco's experience

    International Nuclear Information System (INIS)

    Schwartz, F.

    2006-01-01

    This keynote address discussed an array of solar programs initiated in government-owned buildings in San Francisco. The programs were strongly supported by the city's mayor,and the voting public. Known for its fog and varying microclimates, 11 monitoring stations were set up throughout the city to determine viable locations for the successful application of solar technologies. It was observed that 90 per cent of the available sunshine occurred in the central valley, whereas fog along the Pacific shore was problematic. Seven of the monitoring sites showed excellent results. Relationships with various city departments were described, as well as details of study loads, load profiles, electrical systems, roofs and the structural capabilities of the selected government buildings. There was a focus on developing good relations with the local utility. The Moscone Convention Center was selected for the program's flagship installation, a 675 kW solar project which eventually won the US EPA Green Power Award for 2004 and received high press coverage. Cost of the project was $4.2 million. 825,000 kWh solar electricity was generated, along with 4,500,000 kWh electricity saved annually from efficiency measures, resulting in a net reduction of 5,325,000 kWh. Savings on utilities bills for the center were an estimated $1,078,000. A pipeline of solar projects followed, with installations at a sewage treatment plant and a large recycling depot. A program of smaller sites included libraries, schools and health facilities. Details of plans to apply solar technology to a 500 acre redevelopment site in southeast San Francisco with an aging and inadequate electrical infrastructure were described. A model of efficient solar housing for the development was presented, with details of insulation, windows, heating ventilation and air-conditioning (HVAC), water heating, lighting, appliances and a 1.2 kilowatt solar system. Peak demand reductions were also presented. tabs., figs

  8. Considerações a respeito do uso exclusivo de língua-alvo em curso livre: perspectiva dos professores = Considerations towards the exclusive use of the target language in an english course: teachers’ perspectives

    Directory of Open Access Journals (Sweden)

    Kobielski, Natalie Leal

    2010-01-01

    Full Text Available O presente artigo enfoca a perspectiva dos professores de um curso livre que tem como um dos princípios o uso exclusivo da língua-alvo. A partir de uma fundamentação teórica que discute o papel da L1 em diferentes tipos de métodos e abordagens de ensino, que têm por base diferentes teorias de aquisição de linguagem, foi possível discutir sobre as motivações, vantagens e desvantagens do uso da L1 apontadas pelos professores, bem como a coerência entre tais fatores e o que acontece em sala de aula, em suas práticas de ensino. Questionários escritos e gravações de áudio das aulas dos professores constituíram os instrumentos para a coleta dos dados. Por meio deste estudo, foi possível constatar que não somente o bom senso dos professores com relação ao uso exclusivo da língua-alvo é fundamental, mas também que não é possível classificar a prática dos profissionais sob uma única concepção de aquisição de linguagem, ao ser considerada a relação entre teoria e prática dos professores

  9. San Francisco-Pacifica Coast Landslide Susceptibility 2011

    Data.gov (United States)

    California Natural Resource Agency — The San Francisco-Pacifica Coast grid map was extracted from the California Geological Survey Map Sheet 58 that covers the entire state of California and originally...

  10. San Francisco Bay Multi-beam Bathymetry: Area A

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These multi-beam bathymetric data were collected over shallow subtidal areas in the San Francisco Bay estuary system. Bathymetric and acoustic backscatter data were...

  11. San Francisco Bay Interferometric Side Scan Imagery: Area A

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Backscatter imagery data were collected over shallow subtidal areas in the San Francisco Bay estuary system. Bathymetric and acoustic backscatter data were collected...

  12. National Status and Trends: Bioeffects Program - San Francisco Bay Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This study was based on the sediment quality triad (SQT) approach. A stratified probabilistic sampling design was utilized to characterize the San Francisco Bay...

  13. San Francisco Bay, California 1 arc-second DEM

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1-second San Francisco Bay, California Elevation Grid provides bathymetric data in ASCII raster format of 1-second resolution in geographic coordinates. This...

  14. San Francisco, California Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The San Francisco, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

  15. de novo'' aneurysms following endovascular procedures

    International Nuclear Information System (INIS)

    Briganti, F.; Cirillo, S.; Caranci, F.; Esposito, F.; Maiuri, F.

    2002-01-01

    Two personal cases of ''de novo'' aneurysms of the anterior communicating artery (ACoA) occurring 9 and 4 years, respectively, after endovascular carotid occlusion are described. A review of the 30 reported cases (including our own two) of ''de novo'' aneurysms after occlusion of the major cerebral vessels has shown some features, including a rather long time interval after the endovascular procedure of up to 20-25 years (average 9.6 years), a preferential ACoA (36.3%) and internal carotid artery-posterior communicating artery (ICA-PCoA) (33.3%) location of the ''de novo'' aneurysms, and a 10% rate of multiple aneurysms. These data are compared with those of the group of reported spontaneous ''de novo'' aneurysms after SAH or previous aneurysm clipping. We agree that the frequency of ''de novo'' aneurysms after major-vessel occlusion (two among ten procedures in our series, or 20%) is higher than commonly reported (0 to 11%). For this reason, we suggest that patients who have been submitted to endovascular major-vessel occlusion be followed up for up to 20-25 years after the procedure, using non-invasive imaging studies such as MR angiography and high-resolution CT angiography. On the other hand, periodic digital angiography has a questionable risk-benefit ratio; it may be used when a ''de novo'' aneurysm is detected or suspected on non-invasive studies. The progressive enlargement of the ACoA after carotid occlusion, as described in our case 1, must be considered a radiological finding of risk for ''de novo'' aneurysm formation. (orig.)

  16. San Francisco Bay Water Quality Improvement Fund Project Locations, San Francisco CA, 2017, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — The San Francisco Bay Water Quality Improvement Fund is a competitive grant program that is helping implement TMDLs to improve water quality, protect wetlands, and...

  17. San Francisco Bay Water Quality Improvement Fund Map Service, San Francisco CA, 2012, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — The San Francisco Bay Water Quality Improvement Fund is a competitive grant program that is helping implement TMDLs to improve water quality, protect wetlands, and...

  18. San Francisco Bay Area Baseline Trash Loading Summary Results, San Francisco Bay Area CA, 2012, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — The San Francisco Bay Area stormwater permit sets trash control guidelines for discharges through the storm drain system. The permit covers Alameda, Contra Costa,...

  19. 2010 Northern San Francisco Bay Area Lidar: Portions of Alameda, Contra Costa, Marin, Napa, San Francisco, Solano, and Sonoma Counties

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Light Detection and Ranging (LiDAR) dataset is a survey of northern San Francisco Bay, California. The project area consists of approximately 437 square miles...

  20. The hemodynamic "target": a visual tool of goal-directed therapy for septic patients Alvo hemodinâmico: uma ferramenta visual de terapia "goal-directed" para pacientes sépticos

    Directory of Open Access Journals (Sweden)

    Fabrice Vallée

    2007-01-01

    compreensão do "status" hemodinâmico de pacientes em sepse pelas equipes de enfermagem através da obtenção de parâmetros hemodinâmicos usando um diagrama-alvo pentaxial como ferramenta clínica. Os parâmetros usados foram índice cardíaco, saturação arterial de oxigênio, pressão arterial media, lactato sangüíneo arterial e saturação venosa central de oxigênio. MÉTODOS: Estudo descritivo prospectivo, realizado na Unidade de Terapia Intensiva de um Hospital Universitário. Pacientes: Durante um período de 6 meses, 38 pacientes intubados em choque séptico foram incluídos no estudo. Foram comparados sobreviventes vs. não sobreviventes. Intervenções: Os cinco parâmetros referidos foram medidos nas horas 0, 6, 12, 24, 36 e 48. As medidas foram registradas no diagrama alvo, juntamente com a velocidade de infusão de norepinefrina e nível de hemoglobina. O número de medidas de lactato e saturação venosa central de oxigênio realizado durante o período de estudo foi comparado com um período retrospectivo de 6 meses imediatamente precedendo a introdução do protocolo. Avaliamos o nível de conhecimento das equipes de enfermagem antes da introdução do diagrama-alvo. Após a realização do protocolo realizamos uma nova avaliação. MEDIDAS E RESULTADOS: A equipe de enfermagem exprimiu uma atitude positiva em relação ao conceito de diagrama alvo. O número de medidas de lactato e saturação venosa central de oxigênio foi significativamente menor durante o período controle anterior ao protocolo. E os valores medidos raramente foram empregados como valores meta antes da introdução do diagrama-alvo. Na medida de 24 horas, 46% dos sobreviventes haviam atingido todas as metas do diagrama-alvo, contra apenas 10% dos não sobreviventes (P = 0,01. CONCLUSÃO. O diagrama-alvo é uma ferramenta visual multiparamétrica envolvendo, as equipes médicas e de enfermagem, que auxilia a obtenção de uma estratégia terapêutica para pacientes sépticos. O n

  1. Dos edificios administrativos, en San Francisco

    Directory of Open Access Journals (Sweden)

    Skidmore, Owings & Merrill, Arquitectos

    1964-07-01

    Full Text Available The Crown Zellerbach has been built on a large triangular plaza, at the outskirts of San Francisco. This is one of the most recent tall buildings in the city. The Wells Fargo Bank is also situated on this plaza. It is of special interest, both as regards its shape and functional organisation. It has a ground floor, where most of the mercantile activities take place, and a basement, containing a Council room; the strong rooms, with 2,500 private boxes as well as the bank's own safe; washing rooms; mechanical equipment rooms; a rest room; a bar for the employees and independent stairs. The building has a circular planform, 21.5 m in diameter and 354 m2 in area. The structure is metallic, the vertical supports are along the periphery, spaced every 1.626 m. The enclosing curtain walls are glass and anodized aluminium. The roof has radially distributed metal beams, interconnected by prefabricated concrete units, covered with copper sheeting. This bank, shaped like a hunting lodge, and finished with delicate care, contrasts sharply with the powerful volume of the Crown Zellerbach, and of other nearby buildings, and adds distinction to the plaza.Sobre una gran plaza triangular del extrarradio de San Francisco se alzan: el Crown Zellerbach, uno de sus más recientes rascacielos, y un bello pabellón independiente, el Wells Fargo Bank. El resto de la plaza es de dominio público. La originalidad, en forma y organización del segundo, ha hecho que le dediquemos la mayor atención: consta de una planta baja, en la que se desarrollan, prácticamente, todas las actividades mercantiles, y un piso inferior, en donde se distribuyen: un Salón de Consejos, el departamento de cajas de seguridad, con 2.500 unidades, y las cajas del Banco, los aseos, equipos mecánicos, etc., una sala de descanso y bar para los empleados, con escalera de acceso independiente. Tiene planta circular, de 21,5 m de diámetro y 354 m2 de superficie. La estructura es metálica, con

  2. Mercury in San Francisco Bay forage fish

    Energy Technology Data Exchange (ETDEWEB)

    Greenfield, Ben K., E-mail: ben@sfei.or [San Francisco Estuary Institute, 7770 Pardee Lane, Oakland, CA 94621 (United States); Jahn, Andrew, E-mail: andyjahn@mac.co [1000 Riverside Drive, Ukiah, CA 95482 (United States)

    2010-08-15

    In the San Francisco Estuary, management actions including tidal marsh restoration could change fish mercury (Hg) concentrations. From 2005 to 2007, small forage fish were collected and analyzed to identify spatial and interannual variation in biotic methylmercury (MeHg) exposure. The average whole body total Hg concentration was 0.052 {mu}g g{sup -1} (wet-weight) for 457 composite samples representing 13 fish species. MeHg constituted 94% of total Hg. At a given length, Hg concentrations were higher in nearshore mudflat and wetland species (Clevelandia ios, Menidia audens, and Ilypnus gilberti), compared to species that move offshore (e.g., Atherinops affinis and Lepidogobius lepidus). Gut content analysis indicated similar diets between Atherinops affinis and Menidia audens, when sampled at the same locations. Hg concentrations were higher in sites closest to the Guadalupe River, which drains a watershed impacted by historic Hg mining. Results demonstrate that despite differences among years and fish species, nearshore forage fish exhibit consistent Hg spatial gradients. - Total mercury in estuarine forage fish varies with species, habitat, and proximity to a historic mercury mine.

  3. Trans Women Doing Sex in San Francisco.

    Science.gov (United States)

    Williams, Colin J; Weinberg, Martin S; Rosenberger, Joshua G

    2016-10-01

    This research investigates the sexuality of trans women (individuals who were assigned male status at birth who currently identify as women), by focusing on the "bodily techniques" (Crossley, 2006) they use in "doing" sexuality. The "doing sexuality" framework not only is modeled after the "doing gender" approach of West and Zimmerman (1987), but also utilizes the idea of "sexual embodiment" to emphasize the agency of trans women as they conceptualize and organize their sexuality in a socially recognized way. This is often difficult as they confront discrimination from medical and legal professionals as well as intimate partners who may find it difficult to adapt to the trans woman's atypical body and conception of gender. However, with a study group of 25 trans women from San Francisco, we found the study participants to be adept at overcoming such hurdles and developing techniques to "do" their sexuality. At the same time, we found trans women's agency constrained by the erotic habitus (Green, 2008) of the wider society. The interplay between innovation and cultural tradition provides an opportunity to fashion a more general model of "doing" sexuality.

  4. Mercury in San Francisco Bay forage fish

    International Nuclear Information System (INIS)

    Greenfield, Ben K.; Jahn, Andrew

    2010-01-01

    In the San Francisco Estuary, management actions including tidal marsh restoration could change fish mercury (Hg) concentrations. From 2005 to 2007, small forage fish were collected and analyzed to identify spatial and interannual variation in biotic methylmercury (MeHg) exposure. The average whole body total Hg concentration was 0.052 μg g -1 (wet-weight) for 457 composite samples representing 13 fish species. MeHg constituted 94% of total Hg. At a given length, Hg concentrations were higher in nearshore mudflat and wetland species (Clevelandia ios, Menidia audens, and Ilypnus gilberti), compared to species that move offshore (e.g., Atherinops affinis and Lepidogobius lepidus). Gut content analysis indicated similar diets between Atherinops affinis and Menidia audens, when sampled at the same locations. Hg concentrations were higher in sites closest to the Guadalupe River, which drains a watershed impacted by historic Hg mining. Results demonstrate that despite differences among years and fish species, nearshore forage fish exhibit consistent Hg spatial gradients. - Total mercury in estuarine forage fish varies with species, habitat, and proximity to a historic mercury mine.

  5. DeNovoGUI: an open source graphical user interface for de novo sequencing of tandem mass spectra.

    Science.gov (United States)

    Muth, Thilo; Weilnböck, Lisa; Rapp, Erdmann; Huber, Christian G; Martens, Lennart; Vaudel, Marc; Barsnes, Harald

    2014-02-07

    De novo sequencing is a popular technique in proteomics for identifying peptides from tandem mass spectra without having to rely on a protein sequence database. Despite the strong potential of de novo sequencing algorithms, their adoption threshold remains quite high. We here present a user-friendly and lightweight graphical user interface called DeNovoGUI for running parallelized versions of the freely available de novo sequencing software PepNovo+, greatly simplifying the use of de novo sequencing in proteomics. Our platform-independent software is freely available under the permissible Apache2 open source license. Source code, binaries, and additional documentation are available at http://denovogui.googlecode.com .

  6. ASTER Images San Francisco Bay Area

    Science.gov (United States)

    2000-01-01

    These images of the San Francisco Bay region were acquired on March 3, 2000 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. Each covers an area 60 kilometers (37 miles) wide and 75 kilometers (47 miles) long. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER will image the Earth for the next 6 years to map and monitor the changing surface of our planet.Upper Left: The color infrared composite uses bands in the visible and reflected infrared. Vegetation is red, urban areas are gray; sediment in the bays shows up as lighter shades of blue. Thanks to the 15 meter (50-foot) spatial resolution, shadows of the towers along the Bay Bridge can be seen.Upper right: A composite of bands in the short wave infrared displays differences in soils and rocks in the mountainous areas. Even though these regions appear entirely vegetated in the visible, enough surface shows through openings in the vegetation to allow the ground to be imaged.Lower left: This composite of multispectral thermal bands shows differences in urban materials in varying colors. Separation of materials is due to differences in thermal emission properties, analogous to colors in the visible.Lower right: This is a color coded temperature image of water temperature, derived from the thermal bands. Warm waters are in white and yellow, colder waters are blue. Suisun Bay in the upper right is fed directly from the cold Sacramento River. As the water flows through San Pablo and San Francisco Bays on the way to the Pacific, the waters warm up.Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of International Trade and Industry. A joint U.S./Japan science team is responsible for

  7. Modular Engineering Concept at Novo Nordisk Engineering

    DEFF Research Database (Denmark)

    Moelgaard, Gert; Miller, Thomas Dedenroth

    1997-01-01

    This report describes the concept of a new engineering method at Novo Nordisk Engineering: Modular Engineering (ME). Three tools are designed to support project phases with different levels of detailing and abstraction. ME supports a standard, cross-functional breakdown of projects that facilitates...

  8. San Francisco urban partnership agreement, national evaluation : exogenous factors test plan.

    Science.gov (United States)

    2011-06-01

    This report presents the test plan for collecting and analyzing exogenous factors data for the San Francisco Urban : Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. : The San Francisco UPA proj...

  9. Vabariigi aastapäev San Franciscos / Heino Valvur ; foto: Heino Valvur

    Index Scriptorium Estoniae

    Valvur, Heino

    2006-01-01

    veebruarikuu möödus San Franciscos Eesti Vabariigi 88. aastapäeva pühitsedes: traditsiooniliselt tähistas aastapäeva San Francisco Seenioride Klubi koosviibimisega, E.E.L.K. San Francisco koguduses peeti jumalateenistus ja koosviibimine, kus noored esitasid rahvalaule, San Francisco Eesti Selts tähistas aastapäeva 25. veebruaril aktuse ja koosviibimisega

  10. Merchandising of cigarettes in San Francisco pharmacies: 27 years later.

    Science.gov (United States)

    Eule, B; Sullivan, M K; Schroeder, S A; Hudmon, K S

    2004-12-01

    To estimate changes since 1976 in the proportion of San Francisco pharmacies that sell cigarettes and to characterise the advertising of cigarettes and the merchandising of non-prescription nicotine replacement therapy (NRT) products in these retail establishments. 100 randomly selected San Francisco pharmacies were visited in 2003. Pharmacies were characterised based on the sale of cigarettes, advertising for cigarettes, and the merchandising of non-prescription NRT products. In 2003, 61% of pharmacies sold cigarettes, a significant decrease compared to 89% of pharmacies selling cigarettes in 1976 (p merchandise the primary known risk factor for death in the USA.

  11. Francisco Pino: el poeta de los agujeros

    Directory of Open Access Journals (Sweden)

    Esperanza Ortega

    2014-03-01

    Full Text Available La obra de Francisco Pino (1910-2002, en sus dos vertientes, experimental y no-experimental, posee una coherencia absoluta en cuanto a su concepción creacionista, que considera el poema como «manifestación de existencia». En este contexto aparecen en los años setenta sus libros de agujeros troquelados, que son su característica más relevante y constituyen una muestra de osadía artística y rebeldía vital. Estos libros de agujeros, minúsculas maquetas del uni-verso, poseen un sentido metafísico-religioso: Pino representa en ellos el vacío y el silencio consustancial a la poesía como música inaudible y espacio invisible, y nos ofrece los planos de una arquitectura poética que comunica con el infinito por medio de la ventana troquelada. Hay una búsqueda de la palabra poética total en toda su obra, desde sus primeros versos, en los que ya aparecen intuiciones reveladoras de sus hallazgos posteriores. Aunque, para Pino, la poesía es búsqueda constante, persecución de una presa inalcanzable. En esa persecución, hallará los caligramas, los libros troquelados y los poemas visua-les realizados en todo tipo de soportes desechables, pues Pino afirmó siempre su deseo de permanecer en la órbita de lo efímero, ajeno al anhelo de eterni-dad y ajeno también a las convenciones de la Historia del Arte, aunque su postura condenara a su obra al ostracismo o la expusiera a la irrisión. En la ilustración de uno de sus últimos libros, el titulado Tejas: lugar de Dios. Obertura, un pájaro se deshace en el poema. Sin trino ni mensaje posible, el poeta recoge la pluma del pájaro y con ella escribe. Así pues, la poesía surge tras la destrucción del poeta, como consecuencia de su disolución en el texto, una inmolación feliz e inexplicable, que inunda de luz cegadora el poema, iluminándole, sin llegar a desvelar su misterio.

  12. 77 FR 59969 - Notice of Inventory Completion: San Francisco State University, Department of Anthropology, San...

    Science.gov (United States)

    2012-10-01

    ... Inventory Completion: San Francisco State University, Department of Anthropology, San Francisco, CA... Francisco State University, NAGPRA Program (formerly in the Department of Anthropology). The human remains... State University Department of Anthropology records. In the Federal Register (73 FR 30156-30158, May 23...

  13. Extreme-Scale De Novo Genome Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Georganas, Evangelos [Intel Corporation, Santa Clara, CA (United States); Hofmeyr, Steven [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint Genome Inst.; Egan, Rob [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Computational Research Division; Buluc, Aydin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint Genome Inst.; Oliker, Leonid [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint Genome Inst.; Rokhsar, Daniel [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Computational Research Division; Yelick, Katherine [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint Genome Inst.

    2017-09-26

    De novo whole genome assembly reconstructs genomic sequence from short, overlapping, and potentially erroneous DNA segments and is one of the most important computations in modern genomics. This work presents HipMER, a high-quality end-to-end de novo assembler designed for extreme scale analysis, via efficient parallelization of the Meraculous code. Genome assembly software has many components, each of which stresses different components of a computer system. This chapter explains the computational challenges involved in each step of the HipMer pipeline, the key distributed data structures, and communication costs in detail. We present performance results of assembling the human genome and the large hexaploid wheat genome on large supercomputers up to tens of thousands of cores.

  14. Wegener's granulomatosis occurring de novo during pregnancy.

    Science.gov (United States)

    Alfhaily, F; Watts, R; Leather, A

    2009-01-01

    Wegener's granulomatosis (WG) is rarely diagnosed during the reproductive years and uncommonly manifests for the first time during pregnancy. We report a case of de novo WG presenting at 30 weeks gestation with classical symptoms of WG (ENT, pulmonary). The diagnosis was confirmed by radiological, laboratory, and histological investigations. With a multidisciplinary approach, she had a successful vaginal delivery of a healthy baby. She was treated successfully by a combination of steroids, azathioprine and intravenous immunoglobulin in the active phase of disease for induction of remission and by azathioprine and steroids for maintenance of remission. The significant improvement in her symptoms allowed us to continue her pregnancy to 37 weeks when delivery was electively induced. Transplacental transmission of PR3-ANCA occurred but the neonate remained well. This case of de novo WG during pregnancy highlights the seriousness of this disease and the challenge in management of such patients.

  15. Ethnicity and Phonetic Variation in a San Francisco Neighborhood

    Science.gov (United States)

    Hall-Lew, Lauren

    2009-01-01

    This dissertation advances research in sociolinguistics by analyzing phonetic variation in a majority Asian American community in San Francisco, California. As one of the first community studies focusing on Asian Americans in an urban US context, this work speaks to ongoing discussions about speaker ethnicity, phonetic variation, and regional…

  16. Auckland--New Zealand's Los Angeles or San Francisco?

    Science.gov (United States)

    Bogunovich, Dushko

    1995-01-01

    Compares Auckland (New Zealand) with San Francisco (California) in terms of topographical structure, geographic location, and urban development. Both cities contain striking similarities. Maintains that Auckland can become a world-class city renowned for its beauty if developers and government work in tandem. (MJP)

  17. Working Paper for the Revision of San Francisco's Cable Franchise.

    Science.gov (United States)

    San Francisco Public Library, CA. Video Task Force.

    Ideas are presented for the revision of San Francisco's cable franchise. The recommendations in the report are based upon national research of library and urban use of cable communications and are designed to help the city's present and future cable franchises to comply with the regulations of the Federal Communications Commission by March 31,…

  18. The poetics of Francisco Pino, rare avis in Spanish poetry

    NARCIS (Netherlands)

    Hermans, Hub.

    Francisco Pino (1910-2002) can be considered as a "rara avis" in Spanish poetry. Having published dozens of books rather anonymously, and generally with small private presses, he began publishing through more renowned publishing companies in 1978. His various new editions, anthologies and editions

  19. Solar for Your Present Home. San Francisco Bay Area Edition.

    Science.gov (United States)

    Barnaby, Charles S.; And Others

    This publication provides information about present uses of solar energy for space, water, and swimming pool heating that are practical for the San Francisco Bay area. It attempts to provide interested persons with the information needed to make decisions regarding installations of solar heating systems. The point of view taken is that any…

  20. MRUniNovo: an efficient tool for de novo peptide sequencing utilizing the hadoop distributed computing framework.

    Science.gov (United States)

    Li, Chuang; Chen, Tao; He, Qiang; Zhu, Yunping; Li, Kenli

    2017-03-15

    Tandem mass spectrometry-based de novo peptide sequencing is a complex and time-consuming process. The current algorithms for de novo peptide sequencing cannot rapidly and thoroughly process large mass spectrometry datasets. In this paper, we propose MRUniNovo, a novel tool for parallel de novo peptide sequencing. MRUniNovo parallelizes UniNovo based on the Hadoop compute platform. Our experimental results demonstrate that MRUniNovo significantly reduces the computation time of de novo peptide sequencing without sacrificing the correctness and accuracy of the results, and thus can process very large datasets that UniNovo cannot. MRUniNovo is an open source software tool implemented in java. The source code and the parameter settings are available at http://bioinfo.hupo.org.cn/MRUniNovo/index.php. s131020002@hnu.edu.cn ; taochen1019@163.com. Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  1. De novo malignancy after pancreas transplantation in Japan.

    Science.gov (United States)

    Tomimaru, Y; Ito, T; Marubashi, S; Kawamoto, K; Tomokuni, A; Asaoka, T; Wada, H; Eguchi, H; Mori, M; Doki, Y; Nagano, H

    2015-04-01

    Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan. Post-transplant patients with de novo malignancy were surveyed and characterized in Japan. Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case. We clarified the incidence of de novo malignancy after pancreas transplantation in Japan. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Novos paradigmas literários

    Directory of Open Access Journals (Sweden)

    Denise Azevedo Duarte Guimarães

    2005-12-01

    Full Text Available O artigo estuda a emergência de novos paradigmas literários, procurando refletir acerca das textualidades contemporâneas. Focaliza os hipertextos informatizados e a poesia multimídia, com o intuito de desvendar como estão sendo criados novos procedimentos expressivos e em que medida eles podem ser identificados com reflexões teóricas anteriores acerca do texto literário impresso. Remete a questões ligadas à leitura dos diferentes tipos de signos e aos modos como eles se integram para a constituição dessas novíssimas linguagens híbridas em novos suportes.El artículo estudia la emergencia de nuevos paradigmas literarios, procurando reflejar acerca de las textualidades contemporáneas. Enfoca los hipertextos informatizados y la poesía multimedia, intentando desvendar cómo están siendo creados nuevos procedimientos expresivos y en qué medida ellos pueden ser identificados a reflexiones teóricas anteriores acerca del texto literario impreso. Remite a cuestiones ligadas a la lectura de los diferentes tipos de signos y a los modos cómo ellos se interaccionan para la constitución de los novísimos lenguajes híbridos en nuevos supuestos.This article investigates the emergence of new literary paradigms as it tries to understand new contemporary textualities. It analyses some hypertexts and multimedia poetry trying to trace how new expressive procedures are being created. How can these new languages be identified and what are their relations to previous theories which dealt with the literary printed text? This study approaches questions linked to the reading of different types of signs and the modes they function towards the fabrication of these new hybrid languages.

  3. De novo autoimmune hepatitis after liver transplantation.

    Science.gov (United States)

    Lohse, Ansgar W; Weiler-Norman, Christina; Burdelski, Martin

    2007-10-01

    The Kings College group was the first to describe a clinical syndrome similar to autoimmune hepatitis in children and young adults transplanted for non-immune mediated liver diseases. They coined the term "de novo autoimmune hepatitis". Several other liver transplant centres confirmed this observation. Even though the condition is uncommon, patients with de novo AIH are now seen in most of the major transplant centres. The disease is usually characterized by features of acute hepatitis in otherwise stable transplant recipients. The most characteristic laboratory hallmark is a marked hypergammaglobulinaemia. Autoantibodies are common, mostly ANA. We described also a case of LKM1-positivity in a patients transplanted for Wilson's disease, however this patients did not develop clinical or histological features of AIH. Development of SLA/LP-autoantibodies is also not described. Therefore, serologically de novo AIH appears to correspond to type 1 AIH. Like classical AIH patients respond promptly to treatment with increased doses of prednisolone and azathioprine, while the calcineurin inhibitors cyclosporine or tacrolimus areof very limited value - which is not surprising, as almost all patients develop de novo AIH while receiving these drugs. Despite the good response to treatment, most patients remain a clinical challenge as complete stable remissions are uncommon and flares, relapses and chronic disease activity can often occur. Pathogenetically this syndrome is intriguing. It is not clear, if the immune response is directed against allo-antigens, neo-antigens in the liver, or self-antigens, possibly shared by donor and host cells. It is very likely that the inflammatory milieu due to alloreactive cells in the transplanted organ contribute to the disease process. Either leading to aberrant antigen presentation, or providing co-stimulatory signals leading to the breaking of self-tolerance. The development of this disease in the presence of treatment with calcineurin

  4. 33 CFR 165.1187 - Security Zones; Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay...

    Science.gov (United States)

    2010-07-01

    ... Limited Access Areas Eleventh Coast Guard District § 165.1187 Security Zones; Golden Gate Bridge and the... Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, in San Francisco Bay, California. (b... siren, radio, flashing light, or other means, the operator of a vessel shall proceed as directed. [COTP...

  5. A emergência de novos gêneros do discurso em decorrência do deslocamento do suporte

    Directory of Open Access Journals (Sweden)

    Gloria Dias Soares Vitorino

    2009-08-01

    Full Text Available RESUMO: Este texto resulta de uma reflexão sobre a percepção de sujeitos-leitores – professores em processo de formação inicial – quanto a uma possível relação entre mesmo texto / novo suporte / diferente gênero do discurso, considerando-se, como quadro teórico central, uma perspectiva bakhtiniana de gênero, além de outros estudos complementares. Para a coleta de dados, tomaram-se, como base, cinco categorias previamente selecionadas pelo professor-pesquisador, a saber: intencionalidade, público-alvo, estratégias lingüísticas e textuais, suporte, gênero do discurso. No estudo realizado, em situação de ensino-aprendizagem, instigaram-se os sujeitos da pesquisa a se valerem das categorias selecionadas para se darem conta dos inúmeros desvios e deslocamentos em que cada vez mais os textos podem estar envolvidos. PALAVRAS-CHAVE: Sujeitos-leitores; Gêneros de Discurso; Suporte. ABSTRACT: This text is the result of a reflection on the perception of subject-readers – teachers in the training process – about a possible relationship between same text / new media / different discourse genre, considering, as central theoretical framework, a view of the Bakhtin genre and additional studies. For data collection, five categories previously selected by the teacher-researcher were taken as a basis, namely intent, target audience, textual and linguistic strategies, support, and discourse genre. In the study, in the teaching-learning situation, the subjects were instigated to use the categories selected to realize the numerous abuses and displacement that the texts may be involved. KEYWORDS: Subject-readers; Discourse genres; Support.Recebido: 21/08/2009       Aceito:21/08/2009

  6. O Desenvolvimento do Enoturismo no Vale do São Francisco: um segmento em expansão

    Directory of Open Access Journals (Sweden)

    Pollyana Pugas Dias

    2012-12-01

    Full Text Available Resumo

    A região do Vale do São Francisco vem se destacando no cenário nacional como o mais novo destino enoturístico. A atividade cresce no mundo como uma alternativa interessante para as regiões vitivinicultoras agregarem valor aos seus produtos e diversificarem a fonte geradora de renda ao mesmo tempo em que envolvem outros setores da região, distribuindo os frutos do seu negócio. Por meio da realização de entrevistas e de uma extensa pesquisa de dados secundários, este trabalho objetivou descrever como esse processo vem se desenvolvendo em pleno semiárido nordestino. Verificou-se como principais evidências do franco crescimento do enoturismo no Vale do São Francisco o envolvimento crescente das vinícolas da região com a atividade, o forte investimento do poder público em prol do segmento e a recente diversificação dos produtos turísticos oferecidos. Os bons resultados que o enoturismo vem apresentando na região podem ser atribuídos ao esforço e integração dos agentes envolvidos e ao contraste de paisagens promovido pela inserção da atividade de fruticultura irrigada, e deve ser interpretada como ferramenta de transformação social e econômica.

    Palavras-chave: turismo; Vale do São Francisco; vitivinicultura. AbstractThe region

  7. New fault picture points toward San Francisco Bay area earthquakes

    Science.gov (United States)

    Kerr, R. A.

    1989-01-01

    Recent earthquakes and a new way of looking at faults suggest that damaging earthquakes are closing in on the San Francisco area. Earthquakes Awareness Week 1989 in northern California started off with a bang on Monday, 3 April, when a magnitude 4.8 earthquake struck 15 kilometers northeast of San Jose. The relatively small shock-its primary damage was the shattering of an air-control tower window-got the immediate attention of three U.S Geological Survey seismologists in Menlo Park near San Francisco. David Oppenheimer, William Bakun, and Allan Lindh had forecast a nearby earthquake in a just completed report, and this, they thought, might be it. 

  8. IDEOLOGIA E TRANSITIVIDADE NO DISCURSO DO PAPA FRANCISCO

    Directory of Open Access Journals (Sweden)

    Vinícius Nicéas Nascimento (UFPE

    2015-09-01

    Full Text Available

    Este artigo tem como objetivo principal apresentar uma análise dos Processos mentais presentes nos pronunciamentos do Papa Francisco proferidos durante a Jornada Mundial da Juventude 2013. Nossa pesquisa fundamentou-se na Linguística Sistêmico-Funcional, na sua concepção da língua como atividade social, e na Análise Crítica do Discurso. Observamos o sistema de transitividade e os diversos processos verbais, bem como os aspectos ideológicos que permearam os pronunciamentos analisados. Os resultados obtidos nos possibilitam perceber que os processos mentais analisados são, nos pronunciamentos do Papa Francisco, corresponsáveis pela construção da argumentação e do sentido e indicam a maneira como a Igreja Católica sustenta suas relações de poder.

  9. Art at the crossroads: Francisco Oller and Caribbean art

    Directory of Open Access Journals (Sweden)

    Katherine Manthorne

    2015-12-01

    Full Text Available Review of Edward J. Sullivan, From San Juan to Paris and Back: Francisco Oller and Caribbean Art in the Era of Impressionism: Francisco Oller (1833-1917 was a Puerto Rican born artist who helped shape the visual production of the Caribbean in the second half of the nineteenth century. He enjoyed a reputation on both sides of the Atlantic, both at home and in Europe, where he spent twenty years. This book fills provides a much-needed analysis of the achievement of Oller, who has received little scholarly attention in the past thirty years. In six chapters that analyze major artworks and themes in Oller’s oeuvre, this book recasts the artist as a key figure in nineteenth century art and sheds new light on his contribution to a uniquely Caribbean aesthetic.

  10. Aggregate Settling Velocities in San Francisco Estuary Margins

    Science.gov (United States)

    Allen, R. M.; Stacey, M. T.; Variano, E. A.

    2015-12-01

    One way that humans impact aquatic ecosystems is by adding nutrients and contaminants, which can propagate up the food web and cause blooms and die-offs, respectively. Often, these chemicals are attached to fine sediments, and thus where sediments go, so do these anthropogenic influences. Vertical motion of sediments is important for sinking and burial, and also for indirect effects on horizontal transport. The dynamics of sinking sediment (often in aggregates) are complex, thus we need field data to test and validate existing models. San Francisco Bay is well studied and is often used as a test case for new measurement and model techniques (Barnard et al. 2013). Settling velocities for aggregates vary between 4*10-5 to 1.6*10-2 m/s along the estuary backbone (Manning and Schoellhamer 2013). Model results from South San Francisco Bay shoals suggest two populations of settling particles, one fast (ws of 9 to 5.8*10-4 m/s) and one slow (ws of Brand et al. 2015). While the open waters of San Francisco Bay and other estuaries are well studied and modeled, sediment and contaminants often originate from the margin regions, and the margins remain poorly characterized. We conducted a 24 hour field experiment in a channel slough of South San Francisco Bay, and measured settling velocity, turbulence and flow, and suspended sediment concentration. At this margin location, we found average settling velocities of 4-5*10-5 m/s, and saw settling velocities decrease with decreasing suspended sediment concentration. These results are consistent with, though at the low end of, those seen along the estuary center, and they suggest that the two population model that has been successful along the shoals may also apply in the margins.

  11. CONVERSATORIO CON EL PROFESOR DANIEL FRANCISCO JARAMILLO JARAMILLO

    OpenAIRE

    VICTOR IGNACIO LÓPEZ RÍOS

    2016-01-01

    Daniel Francisco Jaramillo Jaramillo es ingeniero agronomo de la Universidad Nacional de Colombia, especialista de Fotointerpretacion aplicada a estudios de suelos, Magister en Suelos y Aguas de la Universidad Nacional de Colombia, sede Palmira. Ha participado como reconocedor de suelos en levantamientos realizados en varias regiones de los departamentos de Antioquia, Valle del Cauca, Cundinamarca, Huila. Caldas y La Guajira, y desde hace 35 años esta dedicado a la docencia, en pregr...

  12. De Novo Construction of Redox Active Proteins.

    Science.gov (United States)

    Moser, C C; Sheehan, M M; Ennist, N M; Kodali, G; Bialas, C; Englander, M T; Discher, B M; Dutton, P L

    2016-01-01

    Relatively simple principles can be used to plan and construct de novo proteins that bind redox cofactors and participate in a range of electron-transfer reactions analogous to those seen in natural oxidoreductase proteins. These designed redox proteins are called maquettes. Hydrophobic/hydrophilic binary patterning of heptad repeats of amino acids linked together in a single-chain self-assemble into 4-alpha-helix bundles. These bundles form a robust and adaptable frame for uncovering the default properties of protein embedded cofactors independent of the complexities introduced by generations of natural selection and allow us to better understand what factors can be exploited by man or nature to manipulate the physical chemical properties of these cofactors. Anchoring of redox cofactors such as hemes, light active tetrapyrroles, FeS clusters, and flavins by His and Cys residues allow cofactors to be placed at positions in which electron-tunneling rates between cofactors within or between proteins can be predicted in advance. The modularity of heptad repeat designs facilitates the construction of electron-transfer chains and novel combinations of redox cofactors and new redox cofactor assisted functions. Developing de novo designs that can support cofactor incorporation upon expression in a cell is needed to support a synthetic biology advance that integrates with natural bioenergetic pathways. © 2016 Elsevier Inc. All rights reserved.

  13. Back to the Rio São Francisco valley

    Directory of Open Access Journals (Sweden)

    Hervé Théry

    2015-06-01

    Full Text Available On the occasion of the Fourth French-Brazilian itinerant seminar, “Cities and river in the history of Brazil: Rio São Francisco”, the text revisits articles published in 1978, 1980 and 1981, illustrated with 1977 photographs and new maps. Though often portrayed as one of the most promising regions in Brazil, and despite having been object, for the last seventy years, of various development projects, the São Francisco valley remains one of the most underdeveloped areas of the country. The history of its occupation partly accounts for this situation, as the São Francisco is the river of the sertão. The various attempts at reclaiming the region, since 1946, are due to various motives, some of them political, but they are also due to a mythical view of the São Francisco as being the “river of national unity”. From 1948 to 1967, the CVSF was rather unsuccessful, probably given too many tasks to carry out. Since 1967, the Suvale and then the Codevasf have focused their action on a few areas in which their main activity is irrigation, but the needs of hydroelectric-power threatens its development. The competition for water therefore makes it necessary to reappraise the future of the valley, gradually integrated into the economy of Brazil’s coastal regions.

  14. Microbial diversity in restored wetlands of San Francisco Bay

    Energy Technology Data Exchange (ETDEWEB)

    Theroux, Susanna [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Hartman, Wyatt [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; He, Shaomei [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Univ. of Wisconsin, Madison, WI (United States); Tringe, Susannah [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.

    2013-12-09

    Wetland ecosystems may serve as either a source or a sink for atmospheric carbon and greenhouse gases. This delicate carbon balance is influenced by the activity of belowground microbial communities that return carbon dioxide and methane to the atmosphere. Wetland restoration efforts in the San Francisco Bay-Delta region may help to reverse land subsidence and possibly increase carbon storage in soils. However, the effects of wetland restoration on microbial communities, which mediate soil metabolic activity and carbon cycling, are poorly studied. In an effort to better understand the underlying factors which shape the balance of carbon flux in wetland soils, we targeted the microbial communities in a suite of restored and historic wetlands in the San Francisco Bay-Delta region. Using DNA and RNA sequencing, coupled with greenhouse gas monitoring, we profiled the diversity and metabolic potential of the wetland soil microbial communities along biogeochemical and wetland age gradients. Our results show relationships among geochemical gradients, availability of electron acceptors, and microbial community composition. Our study provides the first genomic glimpse into microbial populations in natural and restored wetlands of the San Francisco Bay-Delta region and provides a valuable benchmark for future studies.

  15. Impact of insecticides on non-target arthropods in watermelon cropImpacto de inseticidas em artrópodes não-alvo associados à cultura da melancia

    Directory of Open Access Journals (Sweden)

    Cíntia Ribeiro Souza

    2012-10-01

    Full Text Available Watermelon Citrullus lunatus (Thunberg, Matsumura & Nakai is an ecosystem having a variety of arthropods, each one playing a specific role. Although some of them are considered pest to crops, some others are responsible for soil aeration, nutrient release and predation of pest species and are, therefore, considered beneficial to crops. The intensive farming practiced for watermelon cultivation in Brazil is based on the use of tiamethoxam and deltamethrin, which may not only kill target but also nontarget organisms such as beneficial arthropods. Research data regarding the influence of insecticides on arthropods in watermelon cropping is scarce. This study aimed to evaluate the effect of the insecticides deltamethrin and thiamethoxam on soil surface and watermelon canopy arthropod community. The study was carried out in the State of Tocantins, Brazil. Although the application of thiamethoxam and deltamethrin was efficient in controlling populations of Aphis gossypii (Glover, as we expected, they negatively affected non-target arthropods such as detritivores insects in the canopy and soil surface. Ecological implications of the impact of such pesticides on beneficial arthropod species are discussed.A cultura da melancia Citrullus lunatus (Thunberg, Matsumura & Nakai abriga uma grande diversidade de artrópodes, cada um desempenhando um papel específico. Apesar de alguns desses artrópodes serem considerados pragas, outros são responsáveis pela aeração do solo, liberação de nutrientes e predação das espécies-praga, sendo, dessa forma, considerados benéficos às culturas. A agricultura intensiva praticada no Brasil para o cultivo da melancia é baseada no uso dos inseticidas como tiamethoxam e deltametrina, que pode não só matar as pragas, mas também organismos não-alvo. Pesquisas relacionadas à influência de inseticidas sobre artrópodes benéficos na cultura da melancia são escassas. Este estudo foi realizado com o objetivo de

  16. DIAGRAMMATIC SCALE TO EVALUATE TARGET SPOT SEVERITY IN CUCUMBER PLANT LEAVES ESCALA DIAGRAMÁTICA PARA AVALIAÇÃO DA SEVERIDADE DA MANCHA ALVO EM FOLHAS DE PEPINEIRO

    Directory of Open Access Journals (Sweden)

    Marise Cagnin Martins

    2011-07-01

    -style: normal; font-weight: normal; line-height: 120%; text-decoration: none;" lang="pt-BR">Devido à ausência de escala diagramática para a mancha alvo do pepineiro, causada por Corynespora cassiicola, verificou-se a necessidade de um sistema de quantificação da doença, que proporcionasse maior rapidez e precisão na obtenção dos resultados. Para tanto, uma escala diagramática foi elaborada, considerando-se o limite máximo e mínimo de severidade da doença observados no campo. Os valores intermediários da escala seguiram incrementos logarítmicos para os sintomas da mancha alvo (0,3%; 0,8%; 2%; 5%; 11,5%; 25%; e 46%. Para a validação da escala, oito avaliadores quantificaram a severidade da doença, em cinquenta folhas com diferentes níveis de doença. Inicialmente, a estimativa da severidade foi feita sem auxílio da escala. A seguir, os mesmos avaliadores, utilizando a

  17. Antimicrobial peptide capsids of de novo design.

    Science.gov (United States)

    De Santis, Emiliana; Alkassem, Hasan; Lamarre, Baptiste; Faruqui, Nilofar; Bella, Angelo; Noble, James E; Micale, Nicola; Ray, Santanu; Burns, Jonathan R; Yon, Alexander R; Hoogenboom, Bart W; Ryadnov, Maxim G

    2017-12-22

    The spread of bacterial resistance to antibiotics poses the need for antimicrobial discovery. With traditional search paradigms being exhausted, approaches that are altogether different from antibiotics may offer promising and creative solutions. Here, we introduce a de novo peptide topology that-by emulating the virus architecture-assembles into discrete antimicrobial capsids. Using the combination of high-resolution and real-time imaging, we demonstrate that these artificial capsids assemble as 20-nm hollow shells that attack bacterial membranes and upon landing on phospholipid bilayers instantaneously (seconds) convert into rapidly expanding pores causing membrane lysis (minutes). The designed capsids show broad antimicrobial activities, thus executing one primary function-they destroy bacteria on contact.

  18. De novo pathway-based biomarker identification

    DEFF Research Database (Denmark)

    Alcaraz, Nicolas; List, Markus; Batra, Richa

    2017-01-01

    in a large cohort of breast cancer samples from The Cancer Genome Atlas (TCGA) revealed that MGs are considerably more stable than SG models, while also providing valuable insight into the cancer hallmarks that drive them. In addition, when tested on an independent benchmark non-TCGA dataset, MG features......Gene expression profiles have been extensively discussed as an aid to guide the therapy by predicting disease outcome for the patients suffering from complex diseases, such as cancer. However, prediction models built upon single-gene (SG) features show poor stability and performance on independent...... on their molecular subtypes can provide a detailed view of the disease and lead to more personalized therapies. We propose and discuss a novel MG approach based on de novo pathways, which for the first time have been used as features in a multi-class setting to predict cancer subtypes. Comprehensive evaluation...

  19. Effects of target location and uncertainty on reaching movements in standing position Los efectos de la ubicación de la diana y la incertidumbre en los movimientos de alcance en la posición vertical Efeitos da localização do alvo e da incerteza em movimentos de alcance na postura ereta

    Directory of Open Access Journals (Sweden)

    Luiz de França Bahia Loureiro Junior

    2012-09-01

    movimientos de alcance en la posición erecta.Os efeitos da localização do alvo e da incerteza quanto à posição do alvo em movimentos de alcance foram investigados. Dez adultos permaneceram em pé em frente a um monitor sensível ao toque. Eles foram instruídos a pressionar com o dedo indicador direito um interruptor e tocar o centro do alvo apresentado no monitor após ele acender, movendo o membro superior rapidamente. O alvo foi mostrado ipsi ou contralateralmente e os participantes tinham ou não certeza sobre a posição do alvo. O tempo de reação (TR e movimento (TM e o erro radial (ER foram avaliados. Os resultados revelaram menor TR (≈35 ms e ER (≈0,19 cm para a condição de certeza e maiores TR (≈8 ms e TM (≈18 ms para os moimentos ao alvo contralateral. Concluindo, esses achados mostraram que os efeitos da incerteza da localização e a posição final do alvo podem ser aplicados para movimentos de alcance na posição ereta.

  20. Swash zone characteristics at Ocean Beach, San Francisco, CA

    Science.gov (United States)

    Erikson, L.H.; Hanes, D.M.; Barnard, P.L.; Gibbs, A.E.

    2007-01-01

    Runup data collected during the summer of 2005 at Ocean Beach, San Francisco, CA are analyzed and considered to be typical summer swash characteristics at this site. Analysis shows that the beach was dissipative with Iribarren numbers between 0.05 and 0.4 and that infragravity energy dominated. Foreshore slopes were mild between 0.01 and 0.05 with swash periods on the order of a minute. Predicted runup heights obtained with six previously developed analytical runup formulae were compared to measured extreme runup statistics. Formulations dependent on offshore wave height, foreshore slope and deep water wavelength gave reasonable results.

  1. Mercury-contaminated hydraulic mining debris in San Francisco Bay

    Science.gov (United States)

    Bouse, Robin M.; Fuller, Christopher C.; Luoma, Samuel N.; Hornberger, Michelle I.; Jaffe, Bruce E.; Smith, Richard E.

    2010-01-01

    The hydraulic gold-mining process used during the California Gold Rush and in many developing countries today contributes enormous amounts of sediment to rivers and streams. Commonly, accompanying this sediment are contaminants such as elemental mercury and cyanide used in the gold extraction process. We show that some of the mercurycontaminated sediment created by hydraulic gold mining in the Sierra Nevada, between 1852 and 1884, ended up over 250 kilometers (km) away in San Francisco Bay; an example of the far-reaching extent of contamination from such activities.

  2. Oil painting on tinplate by Francisco José Resende

    Directory of Open Access Journals (Sweden)

    Ana Rita Veiga

    2010-11-01

    Full Text Available Cet article se concentre sur l'étude des techniques d'exécution, des matériaux et de l'état de conservation de trois peintures à l'huile sur fer-blanc (acier couvert d'étain du peintre portugais Francisco José Resende (1825 – 1893. Bien que le choix de peindre sur un support métallique n'était pas commun au XIXème siècle, cet auteur a exécuté au long de sa vie différentes œuvres sur ce substrat. Dans ces recherches, apparaissent les résultats comparatifs de la technique d'exécution de Francisco Resende et des matériaux présents dans les couches picturales et dans le support des trois œuvres faisant l'objet de l'étude. Bien qu'elles aient été exécutées à des dates similaires, on remarque des problèmes de conservation distincts - notamment les détachements, les cloques et la corrosion -, qui sont décrits et liés aux matériaux constituants des peintures.This article focuses on the study of execution techniques, material composition and condition of three oil paintings on tinplate – a thin sheet of steel coated with tin - by the Portuguese painter Francisco José Resende (1825-1893. Although the choice to paint on a metallic support was not very common in the nineteenth century, the painter executed several works on this support. The comparative results focus on Francisco Resende’s technique of execution, the materials used in the paint layers and on the support of the three works which are being studied. Although executed in the same period, they show different conservation problems - namely delamination and blistering of the paint layers, and also corrosion of the support.

  3. La pena de muerte según Francisco de Vitoria

    OpenAIRE

    Blázquez, Niceto

    1989-01-01

    Francisco de Vitoria defendió la licitud moral de la pena de muerte como castigo jurídico impuesto por la suprema autoridad del Estado contra determinados delincuentes, lo que plantea un problema serio desde el punto de vista de la defensa de los derechos fundamentales del hombre, entre los cuales hay que destacar el primero y más fundamental, cual es el derecho a la propia vida. El maestro de Salamanca sigue sin ninguna reserva la tesis de Santo Tomás, para cuya defensa añade algunos razonam...

  4. Francisco Giner de los Ríos en el campo.

    OpenAIRE

    Anónimo (siglo XX)

    2010-01-01

    1 fot.; papel. - Hombre mayor sentado en campo.Francisco Giner de los Rios, filósofo, ensayista y pedagogo. Fundador y director de la Institución Libre de Enseñanza. (Emulsión de plata de ennegrecimiento directo montada sobre cartulina del mismo tamaño. Imagen muy arrugada y dañada en márgenes. Pequeña pérdida de materia en centro de lateral derecho. Imagen amarillenta y desvanecida). - Procedencia: fondo Miguel de Unamuno. - Buena Conservación.

  5. Proyecto Desarrollo del Sitio Web Biblioteca Perito Francisco P. Moreno

    OpenAIRE

    Coali, Catalina Beatriz

    2005-01-01

    Project presented as final work at the Curso de Especialización en Gestión de Unidades de Información (Specialization Course in Units of Information Management), organized by the Dirección Nacional del Sistema Nacional de Capacitación of the Instituto Nacional de la Administración Pública, in which participated the main libraries of the national public sector. In the frame of the project to reform the Administración de Parques Nacionales’ web site in behalf of the library Perito Francisco P. ...

  6. Los "intelectuales" y el Estado Novo

    Directory of Open Access Journals (Sweden)

    Luís REIS TORGAL

    2010-02-01

    Full Text Available RESUMEN: El concepto de “intelectual” es difícil de definir y sin duda se debate constantemente. Sin embargo, es importante reflexionar sobre él a fin de comprender su significado y los problemas que implica. Sea como fuere, a un Estado autoritario “moderno” se le supone una única ideología que tiene que difundirse por medio de una propaganda bien organizada, proceso en el que los intelectuales desempeñan un papel significativo. El “Nuevo Estado” de Salazar encaja en esta categoría y sin duda el conocimiento acerca de sus “intelectuales” es fundamental. En este artículo, el objetivo es proporcionar algunos ejemplos interesantes de “intelectuales” o de simples “funcionarios políticos” con inclinación intelectual a fin de indicar el sentido y complejidad de un estudio con una dimensión distinta sobre este asunto. A este fin han sido seleccionadas tres personalidades responsables de la actividad ideológica y cultural de gran relieve en el Estado de Salazar: António Ferro, João Ameal y Costa Brochado. Palabras clave: Estado Novo; Authotitarianism; Salazar, António de Oliveira; Intellectuals; Ferro, António; Brochado, Idalino da Costa; Ameal, João. ABSTRACT: The concept of the “intellectual” is difficult to define and undoubtedly constantly debated. It is nevertheless important to reflect on it in order to understand its meaning and the problems involved with it. Be that as it may, a “modern” authoritarian State presumes a single ideology which has to be diffused by means of well-organised propaganda, in which process “intellectuals” play a significant role. Salazar’s “New State” fits this category and, undoubtedly, knowledge about its “intellectuals” is fundamental. The objective in this article is to provide some interesting examples of “intellectuals” or simple “political functionar- ies” with an intellectual bent so as to indicate the sense and complexity of a study of a

  7. Proceedings of the Fourth Social Aspects and Recreation Research Symposium: February 4-6, 2004, San Francisco, California

    Science.gov (United States)

    Patrick T. Tierney; Deborah J. (Tech. coords.) Chavez

    2004-01-01

    The Fourth Social Aspects and Recreation Research (SARR) Symposium was held February 4-6, 2004 in San Francisco, California at the Presidio of San Francisco, a component of Golden Gate National Recreation Area and at San Francisco State University. The theme was: Linking People to the Outdoors: Connections for Healthy Lands, People and Communities.

  8. 77 FR 49865 - Notice of Availability of an Environmental Impact Statement (EIS) for the San Francisco Veterans...

    Science.gov (United States)

    2012-08-17

    ... National Environmental Policy Act (NEPA) of 1969, as amended, (42 U.S.C. 4331 et seq.), the Council on...) for the San Francisco Veterans Affairs Medical Center (SFVAMC) Long Range Development Plan (LRDP... Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121 or by telephone...

  9. Characteristics of AA amyloidosis patients in San Francisco.

    Science.gov (United States)

    Lejmi, Hiba; Jen, Kuang-Yu; Olson, Jean L; James, Sam H; Sam, Ramin

    2016-04-01

    AA amyloidosis due to subcutaneous injection of drugs of abuse has been described in the USA, but all the existing literature is from more than 20 years ago. There is more recent literature from Europe. We have observed a high incidence of AA amyloidosis in the county hospital in San Francisco. Here, we describe 24 patients who had kidney biopsy-proven AA amyloidosis from our hospital from 1998 to 2013. All the patients were thought to have AA amyloidosis from skin popping of illicit drugs after having exhausted the intravenous route. These patients with biopsy-proven AA amyloidosis were analysed further. All patients were found to have hepatitis C infection, hypertension was not common, most had advanced kidney failure, and acidosis was common as was tubulointerstitial involvement on the kidney biopsy. Other organ involvement included hepatomegaly and splenomegaly in a number of patients; direct myocardial involvement was not seen, but pulmonary hypertension, history of deep vein thrombosis and pulmonary embolism were common. The prognosis of these patients was poor. The mortality rate approached 50% 1 year after biopsy, and most of the patient needed dialysis shortly after diagnosis. Cessation of drug use seemed beneficial but rarely achievable. AA amyloidosis from skin popping is common in San Francisco. Most patients with renal involvement end up on dialysis, and mortality rates are exceedingly high. © 2015 Asian Pacific Society of Nephrology.

  10. Icarus: visualizer for de novo assembly evaluation.

    Science.gov (United States)

    Mikheenko, Alla; Valin, Gleb; Prjibelski, Andrey; Saveliev, Vladislav; Gurevich, Alexey

    2016-11-01

    : Data visualization plays an increasingly important role in NGS data analysis. With advances in both sequencing and computational technologies, it has become a new bottleneck in genomics studies. Indeed, evaluation of de novo genome assemblies is one of the areas that can benefit from the visualization. However, even though multiple quality assessment methods are now available, existing visualization tools are hardly suitable for this purpose. Here, we present Icarus-a novel genome visualizer for accurate assessment and analysis of genomic draft assemblies, which is based on the tool QUAST. Icarus can be used in studies where a related reference genome is available, as well as for non-model organisms. The tool is available online and as a standalone application. http://cab.spbu.ru/software/icarus CONTACT: aleksey.gurevich@spbu.ruSupplementary information: Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  11. [Diagnosis and management of de novo epilepsy].

    Science.gov (United States)

    Louise, Tyvaert

    2018-03-01

    The diagnosis of de novo epilepsy is complex. An accurate diagnostic approach has to be followed based on specific key steps. Epileptic seizure or non-epileptic malaise: risk of diagnosis error around 20%. Facing a first unprovoked seizure, the practitioner has to know the risk factors specifically linked to an increase risk of seizure recurrence. In presence of these factors, an antiepileptic drug would be indicated. The first antiepileptic drug has to be highly selected according to the epilepsy type and causes but also to the patient characteristics (sex, age, comorbidities, associated drugs, profession, and way of life…) An exhaustive patient Education needs to support the first antiepileptic drug prescription: (sleep and nutritional advices, benefit of observance, antiepileptic drugs features and side effects, follow-up, prognosis…) A regular follow-up is essential to control the observance, tolerability and efficacy of the antiepileptic drug, and to control also the good acceptance of the disease. A systematic research of common comorbidities may be also performed. Electroencephalogram and antiepileptic drugs levels are unnecessary in the classical follow up of known epileptic patients (except specific cases). Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  12. De novo origin of human protein-coding genes.

    Directory of Open Access Journals (Sweden)

    Dong-Dong Wu

    2011-11-01

    Full Text Available The de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Here we identify 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee. The functionality of these genes is supported by both transcriptional and proteomic evidence. RNA-seq data indicate that these genes have their highest expression levels in the cerebral cortex and testes, which might suggest that these genes contribute to phenotypic traits that are unique to humans, such as improved cognitive ability. Our results are inconsistent with the traditional view that the de novo origin of new genes is very rare, thus there should be greater appreciation of the importance of the de novo origination of genes.

  13. De Novo Origin of Human Protein-Coding Genes

    Science.gov (United States)

    Wu, Dong-Dong; Irwin, David M.; Zhang, Ya-Ping

    2011-01-01

    The de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Here we identify 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee. The functionality of these genes is supported by both transcriptional and proteomic evidence. RNA–seq data indicate that these genes have their highest expression levels in the cerebral cortex and testes, which might suggest that these genes contribute to phenotypic traits that are unique to humans, such as improved cognitive ability. Our results are inconsistent with the traditional view that the de novo origin of new genes is very rare, thus there should be greater appreciation of the importance of the de novo origination of genes. PMID:22102831

  14. Identifying wrong assemblies in de novo short read primary ...

    Indian Academy of Sciences (India)

    2016-08-05

    Aug 5, 2016 ... Most of these assemblies are done using some de novo short read assemblers and other related approaches. .... benchmarking projects like Assemblathon 1, Assemblathon ... from a large insert library (at least 1000 bases).

  15. Arginine de novo and nitric oxide production in disease states

    OpenAIRE

    Luiking, Yvette C.; Ten Have, Gabriella A. M.; Wolfe, Robert R.; Deutz, Nicolaas E. P.

    2012-01-01

    Arginine is derived from dietary protein intake, body protein breakdown, or endogenous de novo arginine production. The latter may be linked to the availability of citrulline, which is the immediate precursor of arginine and limiting factor for de novo arginine production. Arginine metabolism is highly compartmentalized due to the expression of the enzymes involved in arginine metabolism in various organs. A small fraction of arginine enters the NO synthase (NOS) pathway. Tetrahydrobiopterin ...

  16. De Novo Collapsing Glomerulopathy in a Renal Allograft Recipient

    Directory of Open Access Journals (Sweden)

    Kanodia K

    2008-01-01

    Full Text Available Collapsing glomerulopathy (CG, characterized histologically by segmental/global glomerular capillary collapse, podocyte hypertrophy and hypercellularity and tubulo-interstitial injury; is characterized clinically by massive proteinuria and rapid progressive renal failure. CG is known to recur in renal allograft and rarely de novo. We report de novo CG 3 years post-transplant in a patient who received renal allograft from haplo-identical type donor.

  17. Language and national identity in Novo Cinema Galego

    Directory of Open Access Journals (Sweden)

    Brais ROMERO SUÁREZ

    2015-12-01

    Full Text Available The talk of town since its inception in 2010, the Cinema Novo Galego has been successful in all competitions and festivals that has been present. From the FIPRESCI prize in Cannes to the Best Emerging Director at Locarno, this new wave of cinema places Galicia in the world film stage. But does Novo Cinema Galego an accurate representation of Galicia? What's the role of Galicia in this movement?

  18. Logística e Inovação: estudo comparativo dos canais de distribuição e o papel da inovação logística para um pequeno e um grande produtor de uva de mesa da Região do Vale do São Francisco.

    OpenAIRE

    Oliveira, Danillo Rodrigues Silva Bento

    2012-01-01

    O Vale do São Francisco desponta como importante fronteira agrícola no Brasil, com destaque para a fruticultura, em especial a produção de uvas de mesa tanto para a exportação como para mercado interno. Assim, o entendimento dos aspectos logísticos relacionados ao setor torna-se essencial para o desenvolvimento da complexa cadeia produtiva da fruta. O atual cenário empresarial, no qual novos padrões de competitividade foram estabelecidos, tem forçado as empresas a procurarem novas formas ...

  19. Anestesia venosa total com infusão alvo-controlada de remifentanil e propofol para ablação de fibrilação atrial Anestesia venosa total con infusión objeto-controlada de remifentanil y propofol para ablación de la fibrilación atrial Total intravenous anesthesia with target-controlled infusion of remifetanil and propofol for ablation of atrial fibrillation

    Directory of Open Access Journals (Sweden)

    Fernando Squeff Nora

    2009-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A ablação de fibrilação atrial (FA é um procedimento novo em nosso meio, embora seja comum em outros centros. A escolha da anestesia, monitores e cuidados anestesiológicos para esse procedimento, realizado fora do bloco cirúrgico, não tem sido descrita. O objetivo deste relato foi descrever uma técnica de anestesia para a realização de ablação de FA. RELATO DO CASO: Paciente feminina, 49 anos, 73 kg, 155 cm, ASA II por hipertensão arterial sistêmica. A monitorização constou de eletrocardiograma com 12 derivações, oximetria de pulso, frequência cardíaca, eletroencefalografia bispectral para medidas de BIS, taxa de supressão (SR e SEF95 e pressão arterial média (PAM. A indução anestésica foi realizada com propofol por via venosa, em infusão alvo-controlada (IAC, com alvo regulado em 4 µg.mL-1, remifentanil por via venosa, em IAC, com alvo de 3 ng.mL¹, e rocurônio por via venosa em bolus na dose de 0,2 mg.kg-1. O modelo farmacocinético de propofol utilizado foi o descrito por Marsh e incorporado à bomba de propofol PFS®. O modelo farmacocinético de remifentanil utilizado foi o descrito por Minto e incorporado à bomba de infusão Alaris PK®. As concentrações, no local efetor ou biofase, corresponderam às informações obtidas através das bombas de infusão e representaram medidas preditivas das concentrações de ambos os fármacos nos respectivos locais de ação. As concentrações de propofol e de remifentanil foram reguladas de acordo com o BIS e a PAM, respectivamente. CONCLUSÕES: A anestesia venosa total para ablação de FA pode ser uma opção segura, levando-se em conta que não há alteração da eletrofisiologia das vias acessórias. A literatura é escassa a este respeito e novas publicações poderão ou não justificar esta modalidade de anestesia durante ablação de FA.JUSTIFICATIVA Y OBJETIVOS: La ablación de fibrilación atrial (FA es un procedimiento nuevo en

  20. Coastal Adaptation: The Case of Ocean Beach, San Francisco

    Science.gov (United States)

    Cheong, S.

    2012-12-01

    Coastal erosion, storms, sea-level rise, and tsunamis all lead to inundation that puts people and communities at risk. Adapting to these coastal hazards has gained increasing attention with climate change. Instead of promoting one particular strategy such as seawalls or defending against one type of hazard, scholars and practitioners encourage a combination of existing methods and strategies to promote synergistic effects. The recently published Intergovernmental Panel on Climate Change (IPCC) Special Report on climate extremes reflects this trend in the integration of disaster risk management and climate change adaptation. This paper focuses on the roles, compatibilities, and synergies of three coastal adaptation options - engineering, vegetation, and policy - in the case of Ocean Beach in San Francisco. Traditionally engineering approach and ecosystem conservation often have stood in opposition as hard shoreline structures destroy coastal habitats, worsen coastal erosion, divert ocean currents, and prevent the natural migration of shores. A natural migration of shores without structure translates into the abandonment of properties in the coastal zone, and is at odds with property rights and development. For example, policies of relocation, retreat, and insurance may not be popular given the concerns of infrastructure and coastal access. As such, engineering, natural defense, and policy can be more conflictual than complementary. Nonetheless, all these responses are used in combination in many locations. Complementarities and compatibilities, therefore, must be assessed when considering the necessity of engineering responses, natural defense capabilities, and policy options. In this light, the question is how to resolve the problem of mixed responses and short- and long-term interests and values, identify compatibilities, and generate synergies. In the case of Ocean Beach, recent erosions that endangered San Francisco's wastewater treatment system acted as major

  1. Comunidade bacteriana como indicadora do efeito de feijoeiro geneticamente modificado sobre organismos não alvo Bacterial community as an indicator of genetically modified common bean effect on nontarget organisms

    Directory of Open Access Journals (Sweden)

    Adriano Moreira Knupp

    2009-12-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito do feijoeiro geneticamente modificado quanto à resistência ao Bean Golden Mosaic Vírus, BGMV (Olathe M1-4, sobre organismos não alvo. De um experimento implantado no campo, em delineamento inteiramente casualizado, com dois tratamentos (Olathe Pinto e evento elite Olathe M1-4, dois períodos amostrais (estádio V4 e R6 e dez repetições, obtiveram-se células bacterianas cultivadas e não cultivadas da rizosfera e do solo não rizosférico, para as quais se procedeu à extração de DNA total. A região V6-V8 do 16S rDNA foi amplificada para a comunidade bacteriana total, e também realizou-se amplificação com iniciadores específicos para o subgrupo alfa (α do filo Proteobacteria a partir de células não cultivadas. Foram obtidos dendrogramas comparativos entre a variedade Olathe Pinto (convencional e o evento elite Olathe M1-4 (geneticamente modificado utilizando-se o coeficiente de Jaccard e o método UPGMA (Unweighted pair-group method with arithmetic mean. Os agrupamentos obtidos dos perfis de 16S rDNA PCR-DGGE indicam alterações na comunidade bacteriana da rizosfera em função da transformação das plantas são mais notáveis nos perfis obtidos para alfa-proteobacteria. A origem das amostras e o estágio de desenvolvimento das plantas afetam a comunidade bacteriana.The objective of this work was to evaluate the effect of genetically modified common bean for Bean Golden Mosaic Virus, BGMV, resistance (Olathe M1-4 on nontarget organisms. In a field experiment established in a completely randomized design with two treatments (Olathe Pinto cultivar and M1-4 Olathe elite event, two sampling periods (V4 and R6 stages and ten replicates, cultivated and non-cultivated bacterial cells from rhizosphere soil and bulk soil were obtained, and their total DNA was extracted. The V6-V8 region of 16S rDNA was amplified for the whole bacterial community, and primers specific for the alpha (

  2. Rocks and geology in the San Francisco Bay region

    Science.gov (United States)

    Stoffer, Philip W.

    2002-01-01

    The landscape of the San Francisco Bay region is host to a greater variety of rocks than most other regions in the United States. This introductory guide provides illustrated descriptions of 46 common and important varieties of igneous, sedimentary, and metamorphic rock found in the region. Rock types are described in context of their identification qualities, how they form, and where they occur in the region. The guide also provides discussion about of regional geology, plate tectonics, the rock cycle, the significance of the selected rock types in relation to both earth history and the impact of mineral resources on the development in the region. Maps and text also provide information where rocks, fossils, and geologic features can be visited on public lands or in association with public displays in regional museums, park visitor centers, and other public facilities.

  3. Las ideas y la obra de Francisco Pascasio Moreno

    OpenAIRE

    Riccardi, Alberto Carlos

    1989-01-01

    Francisco Pascasio Moreno consagró su vida a servir a la Patria, según su propia definición. Felices aquéllos que, inspirados por altos ideales, los ejecutan en una misión de servicio para contribuir a que los demás seamos mejores. En tal sentido Moreno es un paradigma para todos los argentinos, de hoy y de siempre. Creyó, pensó, actuó, superó tremendas dificultades con voluntad y convicción férreas, y nos legó sus obras, sus ideas y su ejemplo. Fue un auténtico, creativo e inspirado héroe ci...

  4. El doctor Francisco Guerra, bibliófilo

    OpenAIRE

    Sánchez Mariana, Manuel

    2007-01-01

    Biografía del doctor Francisco Guerra, médico y uno de los bibliófilos más representativos de comienzos del s. XXI, poseedor de una importantísima biblioteca, donada por decisión propia, en el año 2006 a la Biblioteca Histórica de la Universidad Complutense. La biblioteca está compuesta por más de 4000 impresos y manuscritos de una variada seleccion de títulos humanísticos y científicos: clásicos griegos, romanos y españoles, clásicos de economía, descubrimiento de América, crónicas españolas...

  5. Francisco de Goya: tres cuadros, tres épocas

    Directory of Open Access Journals (Sweden)

    Arnáiz, José Manuel

    1997-12-01

    Full Text Available The author publishes three works in his opinion belonging to three periods of Goya's activity: The first one The Death of San Francisco Javier is the definitive version based on the "bozetto" now in the Zaragoza Museum which derives from a drawing and canvass by the italian painter Bertucci. The second is The Portrait of Child Pedro Jordan de Urríes, heir of the Marquesado de Ayerbe, as first boom of one of the most aristocratic and rich families of Zaragoza. The third work is a sketch for The Tribunal of the Inquisición now in the Academy of San Fernando with remarkable differences, which raises again the problem of the series of small panels in the Munich Museum. The author includes interesting letters addressed by Matheron to Valentin Carderera asking information about Goya, and reproduce the original text of Goya's letter to Zapater dated of 15th. April 1777, until now homeless.No disponible

  6. Clinicopathologic factors associated with de novo metastatic breast cancer.

    Science.gov (United States)

    Shen, Tiansheng; Siegal, Gene P; Wei, Shi

    2016-12-01

    While breast cancers with distant metastasis at presentation (de novo metastasis) harbor significantly inferior clinical outcomes, there have been limited studies analyzing the clinicopathologic characteristics in this subset of patients. In this study, we analyzed 6126 breast cancers diagnosed between 1998 and 2013 to identify factors associated with de novo metastatic breast cancer. When compared to patients without metastasis at presentation, race, histologic grade, estrogen/progesterone receptor (ER/PR) and HER2 statuses were significantly associated with de novo metastasis in the entire cohort, whereas age, histologic grade, PR and HER2 status were the significant parameters in the subset of patients with locally advanced breast cancer (Stage IIB/III). The patients with de novo metastatic breast cancer had a significant older mean age and a lower proportion of HER2-positive tumors when compared to those with metastatic recurrence. Further, the HER2-rich subtype demonstrated a drastically higher incidence of de novo metastasis when compared to the luminal and triple-negative breast cancers in the entire cohort [odds ratio (OR)=5.68 and 2.27, respectively] and in the patients with locally advanced disease (OR=4.02 and 2.12, respectively), whereas no significant difference was seen between de novo metastatic cancers and those with metastatic recurrence. Moreover, the luminal and HER2-rich subtypes showed bone-seeking (OR=1.92) and liver-homing (OR=2.99) characteristics, respectively, for the sites of de novo metastasis, while the latter was not observed in those with metastatic recurrence. Our data suggest that an algorithm incorporating clinicopathologic factors, especially histologic grade and receptor profile, remains of significant benefit during decision making in newly diagnosed breast cancer in the pursuit of precision medicine. Copyright © 2016 Elsevier GmbH. All rights reserved.

  7. NovoPen Echo® insulin delivery device

    Directory of Open Access Journals (Sweden)

    Hyllested-Winge J

    2016-01-01

    Full Text Available Jacob Hyllested-Winge,1 Thomas Sparre,2 Line Kynemund Pedersen2 1Novo Nordisk Pharma Ltd, Tokyo, Japan; 2Novo Nordisk A/S, Søborg, Denmark Abstract: The introduction of insulin pen devices has provided easier, well-tolerated, and more convenient treatment regimens for patients with diabetes mellitus. When compared with vial and syringe regimens, insulin pens offer a greater clinical efficacy, improved quality of life, and increased dosing accuracy, particularly at low doses. The portable and discreet nature of pen devices reduces the burden on the patient, facilitates adherence, and subsequently contributes to the improvement in glycemic control. NovoPen Echo® is one of the latest members of the NovoPen® family that has been specifically designed for the pediatric population and is the first to combine half-unit increment (=0.5 U of insulin dosing with a simple memory function. The half-unit increment dosing amendments and accurate injection of 0.5 U of insulin are particularly beneficial for children (and insulin-sensitive adults/elders, who often require small insulin doses. The memory function can be used to record the time and amount of the last dose, reducing the fear of double dosing or missing a dose. The memory function also provides parents with extra confidence and security that their child is taking insulin at the correct doses and times. NovoPen Echo is a lightweight, durable insulin delivery pen; it is available in two different colors, which may help to distinguish between different types of insulin, providing more confidence for both users and caregivers. Studies have demonstrated a high level of patient satisfaction, with 80% of users preferring NovoPen Echo to other pediatric insulin pens. Keywords: NovoPen Echo®, memory function, half-unit increment dosing, adherence, children, adolescents 

  8. Wave attenuation across a tidal marsh in San Francisco Bay

    Science.gov (United States)

    Foster-Martinez, Madeline R.; Lacy, Jessica; Ferner, Matthew C.; Variano, Evan A.

    2018-01-01

    Wave attenuation is a central process in the mechanics of a healthy salt marsh. Understanding how wave attenuation varies with vegetation and hydrodynamic conditions informs models of other marsh processes that are a function of wave energy (e.g. sediment transport) and allows for the incorporation of marshes into coastal protection plans. Here, we examine the evolution of wave height across a tidal salt marsh in San Francisco Bay. Instruments were deployed along a cross-shore transect, starting on the mudflat and crossing through zones dominated by Spartina foliosa and Salicornia pacifica. This dataset is the first to quantify wave attenuation for these vegetation species, which are abundant in the intertidal zone of California estuaries. Measurements were collected in the summer and winter to assess seasonal variation in wave attenuation. Calculated drag coefficients of S. foliosa and S. pacifica were similar, indicating equal amounts of vegetation would lead to similar energy dissipation; however, S. pacifica has much greater biomass close to the bed (<20 cm) and retains biomass throughout the year, and therefore, it causes more total attenuation. S. foliosa dies back in the winter, and waves often grow across this section of the marsh. For both vegetation types, attenuation was greatest for low water depths, when the vegetation was emergent. For both seasons, attenuation rates across S. pacifica were the highest and were greater than published attenuation rates across similar (Spartina alterniflora) salt marshes for the comparable depths. These results can inform designs for marsh restorations and management plans in San Francisco Bay and other estuaries containing these species.

  9. Al margen de las Obras de Francisco de la Torre

    Directory of Open Access Journals (Sweden)

    Pérez-Abadín Barro, Soledad

    2003-12-01

    Full Text Available Francisco de la Torre's Works, published by Quevedo in 1631, enclose a second part, described in later years as an «appendix», with translations that did not belong in the original project prepared by the author some decades before. The summary of the 1588 license for printing describes the work's content as «lyric and adonic verse, and bucolic», without mentioning the translations. The new date throws into question the participation of Almeida and Brocense in the preparation and transmission of the manuscript that came to Quevedo. Therefore, the volume of 1631 cannot be considered as an example of salmantin group's collective poetical essay. Related chronological considerations also throw new light on the relationship between the author and Fernando de Herrera.Las Obras de Francisco de la Torre, publicadas por Quevedo en 1631, incluyen una segunda parte, que más tarde se llamaría «apéndice», con traducciones ajenas al proyecto inicial preparado por el propio autor décadas antes. El sumario de la licencia de impresión de 1588 describe el contenido de la obra aprobada como «los versos líricos y adónicos y la bucólica», sin mencionar las traducciones. La nueva fecha lleva a cuestionar el protagonismo de Almeida y el Brócense en la preparación y transmisión del manuscrito que más tarde llegaría a Quevedo. El volumen de 1631, por lo tanto, no puede considerarse como un exponente de un ejercicio poético colectivo del círculo salmantino. Los datos cronológicos también permiten replantear la relación del autor con Fernando de Herrera.

  10. Francisco Giralte y el sepulcro del obispo Gutierre de Carvajal

    Directory of Open Access Journals (Sweden)

    Vasallo Toranzo, Luis

    2013-12-01

    Full Text Available The high valuation placed on the tomb of Bishop Gutierre de Carvajal, sculpted by Francisco de Giralte, resulted in a lawsuit for which the most important artists from Toledo, Alcalá and Madrid were called to testify. Their testimonies, made during the crucial moment when Berruguete died and the court arrived at Madrid are very useful for understanding the artistic appreciation of a work. Thus, relevant artists of the period –Pompeyo Leoni, Nicolás Vergara el Viejo, Jácome Trezo or Juan Bautista de Toledo– attested to the perfect technique, the beauty of the carving, the multiplicity of personages represented next to the dead Bishop, and the wish to achieve their portrait likenesses.La alta tasación alcanzada por el sepulcro del obispo Gutierre de Carvajal, obra de Francisco Giralte, motivó un pleito al que fueron llamados los principales artistas de Toledo, Alcalá y Madrid. Sus testimonios, realizados en el crucial momento en que se produjo la muerte de Berruguete y llegó la corte a Madrid, son muy útiles para conocer la estimación artística de una obra, de la que personajes como Pompeyo Leoni, Nicolás de Vergara el Viejo, Jácome Trezo o Juan Bautista de Toledo ponderaron la perfección técnica, la belleza de su talla, la multiplicación de personajes representados junto al finado y la voluntad retratística presente en todos ellos.

  11. De novo status epilepticus with isolated aphasia.

    Science.gov (United States)

    Flügel, Dominique; Kim, Olaf Chan-Hi; Felbecker, Ansgar; Tettenborn, Barbara

    2015-08-01

    Sudden onset of aphasia is usually due to stroke. Rapid diagnostic workup is necessary if reperfusion therapy is considered. Ictal aphasia is a rare condition but has to be excluded. Perfusion imaging may differentiate acute ischemia from other causes. In dubious cases, EEG is required but is time-consuming and laborious. We report a case where we considered de novo status epilepticus as a cause of aphasia without any lesion even at follow-up. A 62-year-old right-handed woman presented to the emergency department after nurses found her aphasic. She had undergone operative treatment of varicosis 3 days earlier. Apart from hypertension and obesity, no cardiovascular risk factors and no intake of medication other than paracetamol were reported. Neurological examination revealed global aphasia and right pronation in the upper extremity position test. Computed tomography with angiography and perfusion showed no abnormalities. Electroencephalogram performed after the CT scan showed left-sided slowing with high-voltage rhythmic 2/s delta waves but no clear ictal pattern. Intravenous lorazepam did improve EEG slightly, while aphasia did not change. Lumbar puncture was performed which likely excluded encephalitis. Magnetic resonance imaging showed cortical pathological diffusion imaging (restriction) and cortical hyperperfusion in the left parietal region. Intravenous anticonvulsant therapy under continuous EEG resolved neurological symptoms. The patient was kept on anticonvulsant therapy. Magnetic resonance imaging after 6 months showed no abnormalities along with no clinical abnormalities. Magnetic resonance imaging findings were only subtle, and EEG was without clear ictal pattern, so the diagnosis of aphasic status remains with some uncertainty. However, status epilepticus can mimic stroke symptoms and has to be considered in patients with aphasia even when no previous stroke or structural lesions are detectable and EEG shows no epileptic discharges. Epileptic origin is

  12. Biophysical characterization of a de novo elastin

    Science.gov (United States)

    Greenland, Kelly Nicole

    Natural human elastin is found in tissue such as the lungs, arteries, and skin. This protein is formed at birth with no mechanism present to repair or supplement the initial quantity formed. As a result, the functionality and durability of elastin's elasticity is critically important. To date, the mechanics of this ability to stretch and recoil is not fully understood. This study utilizes de novo protein design to create a small library of simplistic versions of elastin-like proteins, demonstrate the elastin-like proteins, maintain elastin's functionality, and inquire into its structure using solution nuclear magnetic resonance (NMR). Elastin is formed from cross-linked tropoelastin. Therefore, the first generation of designed proteins consisted of one protein that utilized homogony of interspecies tropoelastin by using three common domains, two hydrophobic and one cross-linking domains. Basic modifications were made to open the hydrophobic region and also to make the protein easier to purify and characterize. The designed protein maintained its functionality, self-aggregating as the temperature increased. Uniquely, the protein remained self-aggregated as the temperature returned below the critical transition temperature. Self-aggregation was additionally induced by increasing salt concentrations and by modifying the pH. The protein appeared to have little secondary structure when studied with solution NMR. These results fueled a second generation of designed elastin-like proteins. This generation contained variations designed to study the cross-linking domain, one specific hydrophobic domain, and the effect of the length of the elastin-like protein. The cross-linking domain in one variation has been significantly modified while the flanking hydrophobic domains have remained unchanged. This characterization of this protein will answer questions regarding the specificity of the homologous nature of the cross-linking domain of tropoelastin across species. A second

  13. Preferência manual na ação de alcançar em bebês em função da localização espacial do alvo Infants' manual preference in reaching regarding spatial target location

    Directory of Open Access Journals (Sweden)

    Rosana Machado Souza

    2011-01-01

    Full Text Available Preferência manual em bebês de 5 meses de idade foi avaliada em tarefas de alcançar alvos estáticos posicionados na linha média, à direita e à esquerda com referência a coordenadas egocêntricas. A análise da frequência de uso das mãos indicou direção e magnitude de preferência manual diversificadas entre os bebês. Foi observado que os bebês realizaram predominantemente alcances ipsilaterais para alvos posicionados lateralmente. Para alcances na linha média a frequência de uso foi semelhante entre as mãos direita e esquerda. Os resultados sugerem que nessa fase do desenvolvimento a preferência manual para o alcançar é alterada pela posição dos objetos no espaço.Manual preference of 5-month-old infants was evaluated in tasks of reaching static targets positioned on the midline, at the left and right, regarding egocentric coordinates. Frequency analysis of using the hands pointed out to diversified direction and magnitude of manual preference among infants. It was observed that they predominantly made ipsilateral reaches toward targets laterally positioned. Frequency of using the right and left hands was similar for targets located at the midline. The results suggest that in this stage of development manual preference is shifted by the spatial position of the objects.

  14. Physical and chemical properties of San Francisco Bay waters, 1969-1976 (NODC Accession 8400194)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — One magnetic tape containing the physical and chemical properties of San Francisco Bay waters was forwarded to NODC by Mr. Richard Smith of the U.S Geological Survey...

  15. Coastal processes study at Ocean Beach, San Francisco, CA: summary of data collection 2004-2006

    Science.gov (United States)

    Barnard, Patrick L.; Eshleman, Jodi; Erikson, Li H.; Hanes, Daniel M.

    2007-01-01

    Ocean Beach in San Francisco, California, contains a persistent erosional section in the shadow of the San Francisco ebb tidal delta and south of Sloat Boulevard that threatens valuable public infrastructure as well as the safe recreational use of the beach. Coastal managers have been discussing potential mediation measures for over a decade, with little scientific research available to aid in decision making. The United States Geological Survey (USGS) initiated the Ocean Beach Coastal Processes Study in April 2004 to provide the scientific knowledge necessary for coastal managers to make informed management decisions. This study integrates a wide range of field data collection and numerical modeling techniques to document nearshore sediment transport processes at the mouth of San Francisco Bay, with emphasis on how these processes relate to erosion at Ocean Beach. The Ocean Beach Coastal Processes Study is the first comprehensive study of coastal processes at the mouth of San Francisco Bay.

  16. San Francisco urban partnership agreement, national evaluation : content analysis test plan.

    Science.gov (United States)

    2011-06-01

    This report presents the test plan for collecting and analyzing information on outreach activities, media coverage, : and reactions of the public, policy makers, and other groups to the UPA projects for the San Francisco Urban : Partnership Agreement...

  17. San Francisco Bay Area Rapid Transit District (BART) climate change adaptation assessment pilot.

    Science.gov (United States)

    2013-12-01

    The objective of this pilot study was to evaluate the impacts of climate change on the San Francisco Bay Area Rapid Transit District : (BART) infrastructure and to develop and implement adaptation strategies against those impacts. Climate change haza...

  18. San Francisco Bay Water Quality Improvement Fund Points, SF Bay CA, 2015, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — The San Francisco Bay Water Quality Improvement Fund is a competitive grant program that is helping implement TMDLs to improve water quality, protect wetlands, and...

  19. Francisco de Valderrama, verdadero autor de las mazas del Ayuntamiento de Sevilla

    Directory of Open Access Journals (Sweden)

    Santos Márquez, Antonio Joaquín

    2009-06-01

    Full Text Available In this article the author reveals the true creator of the maces of Seville Town Hall, Francisco de Valderrama, a rediscovered silversmith about whom new biographical data is offered. Also included is a detailed study of these civic maces (traditionally attributed erroneously to Francisco de Alfaro, key works of Sevillian Mannerism.

    En este artículo se da a conocer el verdadero autor de las mazas del ayuntamiento de Sevilla, Francisco de Valderrama, orfebre redescubierto del que además aportamos nuevos datos biográficos. Asimismo, hacemos un estudio pormenorizado de estas mazas capitulares, obra clave de la plástica manierista sevillana y que tradicionalmente había sido atribuida erróneamente a Francisco de Alfaro.

  20. Purine biosynthesis de novo by lymphocytes in gout

    International Nuclear Information System (INIS)

    Kamoun, P.; Chanard, J.; Brami, M.; Funck-Brentano, J.L.

    1978-01-01

    A method of measurement in vitro of purine biosynthesis de novo in human circulating blood lymphocytes is proposed. The rate of early reactions of purine biosynthesis de novo was determined by the incorporation of [ 14 C]formate into N-formyl glycinamide ribonucleotide when the subsequent reactions of the metabolic pathway were completely inhibited by the antibiotic azaserine. Synthesis of 14 C-labelled N-formyl glycinamide ribonucleotide by lymphocytes was measured in healthy control subjects and patients with primary gout or hyperuricaemia secondary to renal failure, with or without allopurinol therapy. The average synthesis was higher in gouty patients without therapy than in control subjects, but the values contained overlap the normal range. In secondary hyperuricaemia the synthesis was at same value as in control subjects. These results are in agreement with the inconstant acceleration of purine biosynthesis de novo in gouty patients as seen by others with measurement of [ 14 C]glycine incorporation into urinary uric acid. (author)

  1. Optimization of the daily operation of the plants of Medio Sao Francisco; Otimizacao da operacao diaria das usinas do Medio Sao Francisco

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Jessica Pillon Torralba; Colnago, Glauber Renato; Correia, Paulo de Barros; Ohishi, Takaaki [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Fac. de Engenharia Mecanica. Dept. de Energia], emails: pillon@fem.unicamp.br, colnago@fem.unicamp.br, pcorreia@fem.unicamp.br, taka@densis.fee.unicamp.br

    2010-07-01

    This paper presents an optimization model for daily operation of Sao Francisco hydroelectric power plants. The study considers eight power plants - Sobradinho (USB), Luiz Gonzaga (ULG), Apolonio Sales (UAS), Paulo Afonso I, II, III, (UPA), Paulo Afonso IV (USQ) e Xingo (UXG)- belongs to Sao Francisco Hydroelectric Company (CHESF). Its objective is to maximize the power plant efficiency and to minimize the number of startup and shutdowns of generating units (GU), simultaneously. Considering those GU are equal, is determined the number of units to be dispatched and their charge. The optimal dispatch, linear and non-linear programming techniques and genetic algorithms (GA) support this article. (author)

  2. Airline Maintenance Manpower Optimization from the De Novo Perspective

    Science.gov (United States)

    Liou, James J. H.; Tzeng, Gwo-Hshiung

    Human resource management (HRM) is an important issue for today’s competitive airline marketing. In this paper, we discuss a multi-objective model designed from the De Novo perspective to help airlines optimize their maintenance manpower portfolio. The effectiveness of the model and solution algorithm is demonstrated in an empirical study of the optimization of the human resources needed for airline line maintenance. Both De Novo and traditional multiple objective programming (MOP) methods are analyzed. A comparison of the results with those of traditional MOP indicates that the proposed model and solution algorithm does provide better performance and an improved human resource portfolio.

  3. Persistent hyperthyroidism and de novo Graves' ophthalmopathy after total thyroidectomy.

    Science.gov (United States)

    Tay, Wei Lin; Loh, Wann Jia; Lee, Lianne Ai Ling; Chng, Chiaw Ling

    2017-01-01

    We report a patient with Graves' disease who remained persistently hyperthyroid after a total thyroidectomy and also developed de novo Graves' ophthalmopathy 5 months after surgery. She was subsequently found to have a mature cystic teratoma containing struma ovarii after undergoing a total hysterectomy and salpingo-oophorectomy for an incidental ovarian lesion. It is important to investigate for other causes of primary hyperthyroidism when thyrotoxicosis persists after total thyroidectomy.TSH receptor antibody may persist after total thyroidectomy and may potentially contribute to the development of de novo Graves' ophthalmopathy.

  4. Demanda dos principais metais e novos materiais : analise de tendencias

    OpenAIRE

    Wilson Trigueiro de Sousa

    1990-01-01

    Resumo: Neste trabalho são analisadas algumas tendências na área de novos materiais na tentativa de obter um melhor entendimento das repercussões das atuais inovações tecnológicas para o setor mineral. Inicialmente são revisados os principais estudos sobre as mudanças ocorridas por volta de 1972/74 no comportamento da demanda dos metais mais importantes. Entre as possíveis causas, está o progresso técnico, que tornou possível o surgimento de novos materiais e o aperfeiçoamento de outros em us...

  5. Discovery of new antitumoral and antibacterial drugs from brazilian plant extracts using high throughput screening Descoberta de novos fármacos anti-tumorais e anti-bacterianos de extratos vegetais brasileiros através de screening em larga escala

    Directory of Open Access Journals (Sweden)

    Riad Naim Younes

    2007-01-01

    Full Text Available Plants have played a significant role in the treatment of cancer and infectious diseases for the last four decades. The discovery and introduction to market of paclitaxel, the vinca alkaloids, etoposide, and many antibacterial drugs support drug discovery programs based on natural products. Natural products have been rediscovered as important tools for drug development despite advances in combinatorial chemistry, due to the complex molecular structures able to interact with mammalian cell targets. The Brazilian flora, the most diverse in the world, has become an interesting spot to prospect for new chemical leads or hits due to its species diversity and associated chemical richness. Screening programs have been established in Brazil as a strategy to identify potentially active substances. High throughput screening techniques allow for the analysis of large numbers of extracts in a relatively short period of time, and can be considered one of the most efficient ways of finding new leads from natural products. An updated review of the current status of the biological screening program is presented and recent results from new antitumoral and antibacterial chemical leads are discussed.Plantas são uma importante fonte de novos protótipos há pelo menos quatro décadas. A descoberta e introdução no mercado de paclitaxel, dos alcalóides da vinca, etoposídeo e muitos agentes antibacterianos têm servido de apoio ao desenvolvimento de programas de descobrimento de novos fármacos baseados em produtos naturais. Produtos naturais foram recentemente redescobertos como importante ferramenta na descoberta de novos fármacos devido às estruturas moleculares complexas capazes de interagir com alvos em células de mamíferos. A flora brasileira, a mais rica do mundo, tornou-se um importante sítio para prospecção de novos protótipos em decorrência da riqueza de espécies vegetais relacionada a uma possível diversidade química. Programas de triagem t

  6. Records of contaminant input to San Francisco Bay

    International Nuclear Information System (INIS)

    Geen, A. van; Luoma, S.N.; Hornberger, M.; Fuller, C.; Pereira, W.; Hostettler, F.; Kvenvolden, K.; Anima, R.; Ritson, P.; Flegal, A.R.

    1994-01-01

    San Francisco Bay, one of the few large estuaries on the West Coast of North America, was subjected to great change as mining, agriculture, industrialization and urbanization accelerated after 1849, and river flows were diverted for agriculture. Trends in contamination were evident in sediment cores analyzed from seven sites. Sedimentation rates increased with human activities. Industrialization was a greater source of contamination than mining. Nearest the mouth of the estuary, concentrations of Hg, Cu, Zn, Pb and PAH began to increase around 1900. Isotopes of Pb indicated sediments were affected by a mixture of atmospheric, industrial and erosional inputs. Peaks in some contaminants were evident since the 1950s, notably Ag, Cd in water (as recorded in foraminifers tests), and DDT. Chromium and vanadium were naturally enriched throughout the cores. Declines in metal concentrations in surface sediments were not evident. Vertical mixing could delay response of sediments to changed metal inputs. Nearer the head of the estuary, contaminant concentrations, TOC and indicators of terrigenous carbon increased sharply where 137 Cs and 239,240 Pu was present (presumably post-1950). Diversion of river flows may have affected accumulation of sediments contaminated by post-war industrialization and acceleration of agricultural development

  7. La pena de muerte según Francisco de Vitoria

    Directory of Open Access Journals (Sweden)

    Niceto BLÁZQUEZ

    2009-11-01

    Full Text Available Francisco de Vitoria defendió la licitud moral de la pena de muerte como castigo jurídico impuesto por la suprema autoridad del Estado contra determinados delincuentes, lo que plantea un problema serio desde el punto de vista de la defensa de los derechos fundamentales del hombre, entre los cuales hay que destacar el primero y más fundamental, cual es el derecho a la propia vida. El maestro de Salamanca sigue sin ninguna reserva la tesis de Santo Tomás, para cuya defensa añade algunos razonamientos apologéticos sobre los cuales me propongo hacer algunas reflexiones críticas. Vitoria plantea el problema siguiendo el orden riguroso de la Suma Teológica, pero teniendo en cuenta el contexto sociológico, religioso y cultural de su tiempo, lo que le lleva a discutir directamente con protestantes y escotistas, frente a los cuales trata de justificar el pensamiento tomasiano sobre la pena capital por parte del estado.

  8. Microbial diversity and carbon cycling in San Francisco Bay wetlands

    Energy Technology Data Exchange (ETDEWEB)

    Theroux, Susanna [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Hartman, Wyatt [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; He, Shaomei [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Univ. of Wisconsin, Madison, WI (United States); Tringe, Susannah [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.

    2014-03-21

    Wetland restoration efforts in San Francisco Bay aim to rebuild habitat for endangered species and provide an effective carbon storage solution, reversing land subsidence caused by a century of industrial and agricultural development. However, the benefits of carbon sequestration may be negated by increased methane production in newly constructed wetlands, making these wetlands net greenhouse gas (GHG) sources to the atmosphere. We investigated the effects of wetland restoration on below-ground microbial communities responsible for GHG cycling in a suite of historic and restored wetlands in SF Bay. Using DNA and RNA sequencing, coupled with real-time GHG monitoring, we profiled the diversity and metabolic potential of wetland soil microbial communities. The wetland soils harbor diverse communities of bacteria and archaea whose membership varies with sampling location, proximity to plant roots and sampling depth. Our results also highlight the dramatic differences in GHG production between historic and restored wetlands and allow us to link microbial community composition and GHG cycling with key environmental variables including salinity, soil carbon and plant species.

  9. São Francisco e os caminhos da pedra

    Directory of Open Access Journals (Sweden)

    Antonio José Faria Góis

    2012-06-01

    Full Text Available A utilização da pedra, no período colonial, limitou-se bastante, em termos locais, à alvenaria e à cantaria, mas também ocorreu seu emprego como material, delimitado, em geral, às obras escultóricas complementares da arquitetura. Uma valorização e ampliação desse limite verificou-se com o lioz, assim como, mais especificamente, em Salvador, com o acréscimo de outros tipos de pedra, igualmente lusitanos e participantes da decoração ambiental. Essa contribuição tem, no conjunto conventual de São Francisco, uma interessante variedade de exemplos, por nós abordada no presente artigo, sendo nosso objetivo indicar dados mais específicos para o exame de um percurso histórico. Partindo do ambiente europeu – não circunscrito à metrópole portuguesa, mas a essa interligado –, tal percurso se reveste do caráter universal que honrosamente nos inclui, dando-nos a oportunidade de avaliar a dimensão cultural e a tradição técnica de obras que enriquecem nosso acervo.

  10. La potestad tributaria en Francisco Suárez

    Directory of Open Access Journals (Sweden)

    Luis Carlos Amezúa Amezúa

    2017-09-01

    Full Text Available Francisco Suárez es el teólogo más relevante de la escuela española de derecho natural o Escuela de Salamanca en sentido amplio. Según piensa, el derecho de imponer tributos justos reside en exclusiva en la autoridad suprema, sin necesitar el consentimiento de las Cortes. El Estado tiene ese poder de establecer leyes tributarias para asegurar la paz, el orden y el buen gobierno de la comunidad. Es el poder más importante entre todas las facultades propias de la soberanía, pero debe respetar las exigencias de un impuesto justo: además de la autoridad legítima, una causa justa y distribución proporcional. En este artículo, desarrollaremos la doctrina de Suárez, su interpretación acerca de la duda probable sobre la injusticia del impuesto, y su aceptación de los impuestos sobre el consumo. Todos estos razonamientos iban dirigidos a fortalecer al gobernante, que debe actuar dentro de un marco ético respetuoso con el bien común.

  11. Los diálogos lucianescos de Francisco Sobrino

    Directory of Open Access Journals (Sweden)

    Nieves Arribas

    2010-12-01

    Full Text Available En 1708, el impresor François Foppens publica en Bruselas los Dialogues Nouveaux [...] de Francisco Sobrino, un oficial reformado y maestro de Corte que plagia, incrementándola, la colección de César Oudin (Dialogos muy apazibles [...] Marc Orry, 1608, quien a su vez había hecho lo propio con los siete de John Minsheu (Pleasant and Delightfull Dialogues, Londres, 1599 en una de la líneas editoriales más importantes, paralela a la de otras constelaciones (como la inaugurada por Noel de Berlaimont de la riquísima tradición paneuropea de coloquios didácticos creados para dar muestras de conversacionalidad a quienes desearan aprender segundas lenguas. De los seis diálogos originales de Sobrino, cuatro son fantasiosos y de éstos, hay tres lucianescos en el sentido de que usan la ‘estrategia de Luciano’ pues sus interlocutores son personajes muertos (Mahoma, Colón, Moctezuma, etc.. Será trazado aquí un análisis de las características de los mismos, con especial atención a los componentes didácticos e ideológicos.

  12. San Francisco Biofuel Program: Brown Grease to Biodiesel Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Jolis, Domènec [San Francisco Public Utilities Commission, San Francisco, CA (United States); Martis, Mary [San Francisco Public Utilities Commission, San Francisco, CA (United States); Jones, Bonnie [San Francisco Public Utilities Commission, San Francisco, CA (United States); Miot, Alex [San Francisco Public Utilities Commission, San Francisco, CA (United States); Ving, Karri [San Francisco Public Utilities Commission, San Francisco, CA (United States); Sierra, Natalie [San Francisco Public Utilities Commission, San Francisco, CA (United States); Niobi, Morayo [San Francisco Public Utilities Commission, San Francisco, CA (United States)

    2013-03-01

    Municipal wastewater treatment facilities have typically been limited to the role of accepting wastewater, treating it to required levels, and disposing of its treatment residuals. However, a new view is emerging which includes wastewater treatment facilities as regional resource recovery centers. This view is a direct result of increasingly stringent regulations, concerns over energy use, carbon footprint, and worldwide depletion of fossil fuel resources. Resources in wastewater include chemical and thermal energy, as well as nutrients, and water. A waste stream such as residual grease, which concentrates in the drainage from restaurants (referred to as Trap Waste), is a good example of a resource with an energy content that can be recovered for beneficial reuse. If left in wastewater, grease accumulates inside of the wastewater collection system and can lead to increased corrosion and pipe blockages that can cause wastewater overflows. Also, grease in wastewater that arrives at the treatment facility can impair the operation of preliminary treatment equipment and is only partly removed in the primary treatment process. In addition, residual grease increases the demand in treatment materials such as oxygen in the secondary treatment process. When disposed of in landfills, grease is likely to undergo anaerobic decay prior to landfill capping, resulting in the atmospheric release of methane, a greenhouse gas (GHG). This research project was therefore conceptualized and implemented by the San Francisco Public Utilities Commission (SFPUC) to test the feasibility of energy recovery from Trap Waste in the form of Biodiesel or Methane gas.

  13. Model-Based GUI Testing Using Uppaal at Novo Nordisk

    DEFF Research Database (Denmark)

    H. Hjort, Ulrik; Rasmussen, Jacob Illum; Larsen, Kim Guldstrand

    2009-01-01

    This paper details a collaboration between Aalborg University and Novo Nordiskin developing an automatic model-based test generation tool for system testing of the graphical user interface of a medical device on an embedded platform. The tool takes as input an UML Statemachine model and generates...

  14. Engineering and introduction of de novo disulphide bridges in ...

    Indian Academy of Sciences (India)

    The engineeringof de novo disulphide bridges has been explored as a means to increase the thermal stability of enzymes in the rationalmethod of protein engineering. In this study, Disulphide by Design software, homology modelling and moleculardynamics simulations were used to select appropriate amino acid pairs for ...

  15. De novo synthesis of milk triglycerides in humans

    Science.gov (United States)

    Mammary gland (MG) de novo lipogenesis contributes significantly to milk fat in animals but little is known in humans. Objective: To test the hypothesis that the incorporation of 13C carbons from [U-13C]glucose into fatty acids (FA) and glycerol in triglycerides (TG) will be greater: 1) in milk tha...

  16. Response monitoring in de novo patients with Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Rita Willemssen

    Full Text Available BACKGROUND: Parkinson's disease (PD is accompanied by dysfunctions in a variety of cognitive processes. One of these is error processing, which depends upon phasic decreases of medial prefrontal dopaminergic activity. Until now, there is no study evaluating these processes in newly diagnosed, untreated patients with PD ("de novo PD". METHODOLOGY/PRINCIPAL FINDINGS: Here we report large changes in performance monitoring processes using event-related potentials (ERPs in de novo PD-patients. The results suggest that increases in medial frontal dopaminergic activity after an error (Ne are decreased, relative to age-matched controls. In contrast, neurophysiological processes reflecting general motor response monitoring (Nc are enhanced in de novo patients. CONCLUSIONS/SIGNIFICANCE: It may be hypothesized that the Nc-increase is at costs of dopaminergic activity after an error; on a functional level errors may not always be detected and correct responses sometimes be misinterpreted as errors. This pattern differs from studies examining patients with a longer history of PD and may reflect compensatory processes, frequently occurring in pre-manifest stages of PD. From a clinical point of view the clearly attenuated Ne in the de novo PD patients may prove a useful additional tool for the early diagnosis of basal ganglia dysfunction in PD.

  17. Foldability of a Natural De Novo Evolved Protein.

    Science.gov (United States)

    Bungard, Dixie; Copple, Jacob S; Yan, Jing; Chhun, Jimmy J; Kumirov, Vlad K; Foy, Scott G; Masel, Joanna; Wysocki, Vicki H; Cordes, Matthew H J

    2017-11-07

    The de novo evolution of protein-coding genes from noncoding DNA is emerging as a source of molecular innovation in biology. Studies of random sequence libraries, however, suggest that young de novo proteins will not fold into compact, specific structures typical of native globular proteins. Here we show that Bsc4, a functional, natural de novo protein encoded by a gene that evolved recently from noncoding DNA in the yeast S. cerevisiae, folds to a partially specific three-dimensional structure. Bsc4 forms soluble, compact oligomers with high β sheet content and a hydrophobic core, and undergoes cooperative, reversible denaturation. Bsc4 lacks a specific quaternary state, however, existing instead as a continuous distribution of oligomer sizes, and binds dyes indicative of amyloid oligomers or molten globules. The combination of native-like and non-native-like properties suggests a rudimentary fold that could potentially act as a functional intermediate in the emergence of new folded proteins de novo. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Towards accurate de novo assembly for genomes with repeats

    NARCIS (Netherlands)

    Bucur, Doina

    2017-01-01

    De novo genome assemblers designed for short k-mer length or using short raw reads are unlikely to recover complex features of the underlying genome, such as repeats hundreds of bases long. We implement a stochastic machine-learning method which obtains accurate assemblies with repeats and

  19. On the performance of de novo pathway enrichment

    DEFF Research Database (Denmark)

    Batra, Richa; Alcaraz, Nicolas; Gitzhofer, Kevin

    2017-01-01

    De novo pathway enrichment is a powerful approach to discover previously uncharacterized molecular mechanisms in addition to already known pathways. To achieve this, condition-specific functional modules are extracted from large interaction networks. Here, we give an overview of the state...

  20. De Novo Coding Variants Are Strongly Associated with Tourette Disorder

    DEFF Research Database (Denmark)

    Willsey, A Jeremy; Fernandez, Thomas V; Yu, Dongmei

    2017-01-01

    Whole-exome sequencing (WES) and de novo variant detection have proven a powerful approach to gene discovery in complex neurodevelopmental disorders. We have completed WES of 325 Tourette disorder trios from the Tourette International Collaborative Genetics cohort and a replication sample of 186 ...

  1. Illumina-based de novo transcriptome sequencing and analysis

    Indian Academy of Sciences (India)

    In the present study, we used Illumina HiSeq technology to perform de novo assembly of heart and musk gland transcriptomes from the Chinese forest musk deer. A total of 239,383 transcripts and 176,450 unigenes were obtained, of which 37,329 unigenes were matched to known sequences in the NCBI nonredundant ...

  2. De novo structural modeling and computational sequence analysis ...

    African Journals Online (AJOL)

    Different bioinformatics tools and machine learning techniques were used for protein structural classification. De novo protein modeling was performed by using I-TASSER server. The final model obtained was accessed by PROCHECK and DFIRE2, which confirmed that the final model is reliable. Until complete biochemical ...

  3. Direct Visualization of De novo Lipogenesis in Single Living Cells

    Science.gov (United States)

    Li, Junjie; Cheng, Ji-Xin

    2014-10-01

    Increased de novo lipogenesis is being increasingly recognized as a hallmark of cancer. Despite recent advances in fluorescence microscopy, autoradiography and mass spectrometry, direct observation of de novo lipogenesis in living systems remains to be challenging. Here, by coupling stimulated Raman scattering (SRS) microscopy with isotope labeled glucose, we were able to trace the dynamic metabolism of glucose in single living cells with high spatial-temporal resolution. As the first direct visualization, we observed that glucose was largely utilized for lipid synthesis in pancreatic cancer cells, which occurs at a much lower rate in immortalized normal pancreatic epithelial cells. By inhibition of glycolysis and fatty acid synthase (FAS), the key enzyme for fatty acid synthesis, we confirmed the deuterium labeled lipids in cancer cells were from de novo lipid synthesis. Interestingly, we also found that prostate cancer cells exhibit relatively lower level of de novo lipogenesis, but higher fatty acid uptake compared to pancreatic cancer cells. Together, our results demonstrate a valuable tool to study dynamic lipid metabolism in cancer and other disorders.

  4. Particulated articular cartilage: CAIS and DeNovo NT.

    Science.gov (United States)

    Farr, Jack; Cole, Brian J; Sherman, Seth; Karas, Vasili

    2012-03-01

    Cartilage Autograft Implantation System (CAIS; DePuy/Mitek, Raynham, MA) and DeNovo Natural Tissue (NT; ISTO, St. Louis, MO) are novel treatment options for focal articular cartilage defects in the knee. These methods involve the implantation of particulated articular cartilage from either autograft or juvenile allograft donor, respectively. In the laboratory and in animal models, both CAIS and DeNovo NT have demonstrated the ability of the transplanted cartilage cells to "escape" from the extracellular matrix, migrate, multiply, and form a new hyaline-like cartilage tissue matrix that integrates with the surrounding host tissue. In clinical practice, the technique for both CAIS and DeNovo NT is straightforward, requiring only a single surgery to affect cartilage repair. Clinical experience is limited, with short-term studies demonstrating both procedures to be safe, feasible, and effective, with improvements in subjective patient scores, and with magnetic resonance imaging evidence of good defect fill. While these treatment options appear promising, prospective randomized controlled studies are necessary to refine the indications and contraindications for both CAIS and DeNovo NT.

  5. Carcinoma de mama: novos conceitos na classificação Breast cancer: new concepts in classification

    Directory of Open Access Journals (Sweden)

    Daniella Serafin Couto Vieira

    2008-01-01

    Full Text Available O carcinoma de mama é a neoplasia maligna mais comum em mulheres. Estudos moleculares do carcinoma de mama, baseados na identificação do perfil de expressão gênica por meio do cDNA microarray, permitiram definir pelo menos cinco sub-grupos distintos: luminal A, luminal B, superexpressão do HER2, basal e normal breast-like. A técnica de tissue microarray (TMA, descrita pela primeira vez em 1998, permitiu estudar, em várias amostras de carcinoma, os perfis de expressão protéica de diferentes neoplasias. No carcinoma de mama, os TMAs têm sido utilizados para validar os achados dos estudos preliminares, identificando, desta forma, os novos subtipos fenotípicos do carcinoma de mama. Dentre os subtipos classicamente descritos, o grupo basal constitui um dos mais intrigantes subtipos tumorais e é freqüentemente associado com pior prognóstico e ausência de alvos terapêuticos definidos. A classificação histopatológica do carcinoma de mama tem pobre valor preditivo. Portanto, a associação entre o diagnóstico histológico com técnicas moleculares nos laboratórios de anatomia patológica, por meio do estudo imunoistoquímico, pode determinar o perfil molecular do carcinoma de mama, buscando melhorar a resposta terapêutica. Este estudo visou resumir os mais recentes conhecimentos em que se baseiam os novos conceitos da classificação do carcinoma de mama.Breast cancer is the principal cause of death from cancer in women. Molecular studies of breast cancer, based in the identification of the molecular profiling techniques through cDNA microarray, had allowed defining at least five distinct sub-group: luminal A, luminal B, HER-2-overexpression, basal and " normal" type breast-like. The technique of tissue microarrays (TMA, described for the first time in 1998, allows to study, in some samples of breast cancer, distinguished by differences in their gene expression patterns, which provide a distinctive molecular portrait for each tumor

  6. Steam, solarization, and tons of prevention: the San Francisco Public Utilities Commission's fight to contain Phytophthoras in San Francisco Bay area restoration sites

    Science.gov (United States)

    Greg Lyman; Jessica Appel; Mia Ingolia; Ellen Natesan; Joe Ortiz

    2017-01-01

    To compensate for unavoidable impacts associated with critical water infrastructure capital improvement projects, the San Francisco Public Utilities Commission (SFPUC) restored over 2,050 acres of riparian, wetland, and upland habitat on watershed lands in Alameda, Santa Clara, and San Mateo Counties. Despite strict bio-sanitation protocols, plant pathogens (...

  7. Genome-wide patterns and properties of de novo mutations in humans

    NARCIS (Netherlands)

    Francioli, Laurent C.; Polak, Paz P.; Koren, Amnon; Menelaou, Androniki; Chun, Sung; Renkens, Ivo; van Duijn, Cornelia M.; Swertz, Morris; Wijmenga, Cisca; van Ommen, Gertjan; Slagboom, P. Eline; Boomsma, Dorret I.; Ye, Kai; Guryev, Victor; Arndt, Peter F.; Kloosterman, Wigard P.; de Bakker, Paul I. W.; Sunyaev, Shamil R.

    Mutations create variation in the population, fuel evolution and cause genetic diseases. Current knowledge about de novo mutations is incomplete and mostly indirect(1-10). Here we analyze 11,020 de novo mutations from the whole genomes of 250 families. We show that de novo mutations in the offspring

  8. Genome-wide patterns and properties of de novo mutations in humans

    NARCIS (Netherlands)

    Francioli, L.C.; Polak, P.P.; Koren, A.; Menelaou, A.; Chun, S.; Renkens, I.; van Duijn, C.M.; Swertz, M.A.; Wijmenga, C.; van Ommen, G.J.; Slagboom, P.E.; Boomsma, D.I.; Ye, K.; Guryev, V.; Arndt, P.F.; Kloosterman, W.P.; Bakker, P.I.W.; Sunyaev, S.R.; Dijk, F.; Neerincx, P.B.T.; Pulit, S.L.; Deelen, P.; Elbers, C.C.; Palamara, P.F.; Pe'er, I.; Abdellaoui, A.; van Oven, M.; Vermaat, M.; Li, M.; Laros, J.F.J.; Stoneking, M.; de Knijff, P.; Kayser, M.; Veldink, J.H.; Van den Berg, L.H.; Byelas, H.; den Dunnen, J.T.; Dijkstra, M.; Amin, N.; van der Velde, K.J.; Hottenga, J.J.; van Setten, J.; van Leeuwen, E.M.; Kanterakis, A.; Kattenberg, V.M.; Karssen, L.C.; van Schaik, B.D.C.; Bot, J.; Nijman, I.J.; van Enckevort, D.; Mei, H.; Koval, V.; Estrada, K.; Medina-Gomez, C.; Lameijer, E.W.; Moed, M.H.; Hehir-Kwa, J.Y.; Handsaker, R.E.; McCarroll, S.A.; Vuzman, D.; Sohail, M.; Hormozdiari, F.; Marschall, T.; Schönhuth, A.; Beekman, M.; de Craen, A.J.; Suchiman, H.E.D.; Hofman, A.; Oostra, B.; Isaacs, A.; Rivadeneira, F.; Uitterlinden, A.G.; Willemsen, G.; Platteel, M.; Pitts, S.J.; Potluri, S.; Sundar, P.; Cox, D.R.; Li, Q.; Li, Y.; Du, Y.; Chen, R.; Cao, H.; Li, N.; Cao, S.; Wang, J.; Bovenberg, J.A.; Brandsma, M.

    2015-01-01

    Mutations create variation in the population, fuel evolution and cause genetic diseases. Current knowledge about de novo mutations is incomplete and mostly indirect. Here we analyze 11,020 de novo mutations from the whole genomes of 250 families. We show that de novo mutations in the offspring of

  9. As “marcas” de uma nova fronteira vinícola: identidade cultural das marcas de vinhos do Vale do São Francisco [doi: 10.5329/RECADM.2014025

    Directory of Open Access Journals (Sweden)

    Suélen Matozo Franco

    2014-12-01

    Full Text Available O polo vitivinícola Vale do São Francisco situa-se no Novo Mundo dos vinhos, onde o desenvolvimento das marcas é a orientação dominante. Assim, a identidade desses vinhos está atrelada à de suas marcas. A identidade marcária, discutida tradicionalmente sob uma orientação estratégico-gerencial, também pode ser concebida como identidade discursiva, resultante de diversos vetores além de formulações estratégicas. Aqui, de forma propositiva, assumimos a identidade de marcas como resultado de processos identificatórios numa cultura, portanto uma identidade cultural, o que se aproxima da concepção discursiva. Buscamos, portanto, compreender como são construídas as identidades das marcas de vinho do Vale do São Francisco. Para tanto, procedemos a uma análise de discurso crítica, com base na Linguística Sistêmico-Funcional de M. A. K. Halliday, de entrevistas realizadas com três grupos de agentes: produtores, consumidores e mediadores. Chegamos a 20 traços identitários, que, agrupados conceitualmente, resultaram em seis identidades culturais: acanhada, competente, jovial, honesta, medíocre e tradicional. Os resultados apontam para uma construção de identidades ancorada num sistema de referências dominante, resultando na desconsideração da tipicidade da região, numa tentativa de sufocar a diferença e alinhar-se ao discurso dominante.. Palavras-Chave Vale do São Francisco, Identidade, Marca, Linguística Sistêmico-Funcional.     “BRANDS” OF A NEW WINERY FRONTIER: SÃO FRANCISCO VALLEY WINE BRANDS’ CULTURAL IDENTITY   ABSTRACT The São Francisco Valley is located in wine’s New World, where the development of brands is the dominant orientation. Thus, the identity of these wines is linked to their brands. The identity mark, traditionally discussed a policy-strategic management, can also be conceived as discursive identity resulting from various vectors as well as strategic formulations. Here, in a purposeful

  10. No ritmo do Vagalume: culturas negras, associativismo dançante e nacionalidade na produção de Francisco Guimarães (1904-1933

    Directory of Open Access Journals (Sweden)

    Leonardo Affonso de Miranda Pereira

    2015-06-01

    Full Text Available Francisco Guimarães, o Vagalume, foi um dos mais populares cronistas e dramaturgos no Rio de Janeiro da Primeira República. Reconhecido pela posteridade pela publicação do livro Na roda do samba, de 1933, nasceu na segunda metade da década de 1870 em uma família de trabalhadores negros. Foi por isso um dos muitos afrodescendentes que, no pós-abolição, tiveram de buscar novos caminhos de sobrevivência e afirmação profissional. Vagalume o fez através de uma produção explicitamente vinculada aos interesses e à linguagem dos trabalhadores negros e mestiços da cidade, cujas práticas dançantes e carnavalescas sempre buscou registrar. Com base em sua trajetória, o artigo se propõe investigar como Vagalume ajudou a definir novas bases para a cultura carioca e brasileira ao longo da Primeira República - em processo que teve na afirmação do samba como ritmo nacional seu resultado mais visível.

  11. Convocando os hermeneutas da república iletrada: o prêmio Francisco Alves - Gathering the hermenauts of illiterate’s republic: the prize Francisco Alves

    Directory of Open Access Journals (Sweden)

    Carlos Roberto da Silva Monarcha, Brasil

    2014-09-01

    Full Text Available Este artigo apresenta resultados de estudos e pesquisas centrados no Prêmio Francisco Alves, instituído pela Academia Brasileira de Letras sob a denominação de O melhor meio de disseminar o ensino primário no Brasil. A pesquisa básica localizou, recuperou e analisou inúmeros artigos e notas publicados na Revista da Academia Brasileira de Letras e, posteriormente, monografias premiadas de intelectuais expressivos: Marques Pinheiro, Jorge Augusto Büchler, Pedro Deodato de Moraes, Achilles Lisboa, Manoel Bomfim e Sud Mennucci. Conclui-se que, durante a sua vigência, o Prêmio Francisco Alves funcionou como convocatória quinquenal dos intelectuais dispostos a pensar e dar a conhecer as possibilidades de outro futuro para o Brasil, pela via da instrução popular disseminada.  Palavras-chave: prêmio Francisco Alves, Academia Brasileira de Letras, escola elementar, instrução popular.GATHERING THE HERMENAUTS OF ILLITERATE’S REPUBLIC: THE PRIZE FRANCISCO ALVESAbstractThis article presents results of studies and researches focused in the Prize Francisco Alves, instituted by Academia Brasileira de Letras under the name The best way to disseminate primary education in Brazil, besides it addresses the origin and trajectory of the prize. The basic research found, recovered, and analyzed several articles and notes published in Revista da Academia Brasileira de Letras and, posteriorly, different prizewinning monographs, of several expressive intellectuals: Marques Pinheiro, Jorge Augusto Büchler, Pedro Deodato de Moraes, Achilles Lisboa, Manoel Bomfim, and Sud Mennucci. It concludes that, during its terms, the prize Francisco Alves worked as a quinquennial call for the intellectuals willing to think and know the possibilities of another future for Brazil, via dissemination of popular instruction.Key-words: Prize Francisco Alves, Brazilian Academy of Letters, elementary school, popular instruction.CONVOCANDO A LOS HERMENÉUTICOS DE LA REP

  12. Edificio para ambulatorio San Francisco – (EE. UU.

    Directory of Open Access Journals (Sweden)

    Reid, John Lyon

    1976-12-01

    Full Text Available The 50,470 m2 the total area of the hospital is distributed as follows: 18,900 m2 for the 22 main clinics and for the additional clinics; 2,770 m2 for complementary activities; and the remaining 28,800 m2 for a parking lot with space for 700 cars. The building occupies a site that slopes strongly towards the north across which runs the pedestrian access from one of the circumference roads to the main façade; the access road for the vehicles leads to the back facade, where the natural slope of the ground has been taken advantage of to build the 5 storey parking building. The two main functions —the clinics and the parking house— are conveniently separated though connected with each other by means of corridors and lifts. The interior design of the clinics is very flexible so as to allow for further enlargements. The patients' waiting rooms are provided with a glazed façade and have a beautiful view over the San Francisco Bay and its surroundings. The construction is entirely of concrete and its structure is calculated ín such a manner as to allow for two additional storeys.Cuenta con una superficie total construida de 50.470 m2, repartidos de la siguiente forma: 18.900 se destinan a la distribución de 22 clínicas principales y otras secundarias; 2.770 a locales de actividades complementarias; y el resto, 28.800 m2, a aparcamiento con capacidad para 700 plazas. El edificio ocupa una parcela fuertemente inclinada hacia el norte, inclinación que permite el acceso peatonal a la clínica, por la fachada principal, desde una de las avenidas perimetrales; y el vehicular, por la fachada posterior, en donde, aprovechando el desnivel del terreno, se han organizado las cinco plantas del aparcamiento. Las dos funciones principales —clínicas y aparcamiento— se hallan convenientemente separadas, estableciéndose el enlace entre los distintos niveles mediante ascensores que relacionan las clínicas, el centro médico, los aparcamientos

  13. Psychiatric Disorders and Substance Use in Homeless Youth: A Preliminary Comparison of San Francisco and Chicago

    Directory of Open Access Journals (Sweden)

    Ernika G. Quimby

    2012-08-01

    Full Text Available Youth homelessness is a growing problem in the United States. The experience of homelessness appears to have numerous adverse consequences, including psychiatric and substance use disorders. This study compared the frequencies of psychiatric disorders, including substance use, between homeless youth (18–24 years-old in San Francisco (N = 31 and Chicago (N = 56. Subjects were administered the Mini International Neuropsychiatric Interview (M.I.N.I. to assess DSM-IV-TR diagnoses and substance use disorders. Eighty-seven percent of the San Francisco youth, and 81% of the Chicago youth met criteria for at least one M.I.N.I. psychiatric diagnosis. Nearly two-thirds of the youth in both samples met criteria for a mood disorder. Approximately one-third met criteria for an anxiety disorder. Thirty-two percent of the San Francisco sample and 18% of the Chicago met criteria for Antisocial Personality Disorder. Approximately 84% of the San Francisco youth and 48% of the Chicago youth met criteria for a substance-related disorder, and more substances were used by San Francisco youth. In conclusion, the high rate of psychiatric disorders in homeless youth provides clear evidence that the mental health needs of this population are significant. Implications are discussed.

  14. A Summary of the San Francisco Tidal Wetlands Restoration Series

    Directory of Open Access Journals (Sweden)

    Larry R. Brown

    2003-10-01

    Full Text Available The four topical articles of the Tidal Wetlands Restoration Series summarized and synthesized much of what is known about tidal wetlands and tidal wetland restoration in the San Francisco Estuary (hereafter “Estuary”. Despite a substantial amount of available information, major uncertainties remain. A major uncertainty with regard to fishes is the net benefit of restored tidal wetlands relative to other habitats for native fishes in different regions of the Estuary given the presence of numerous invasive alien species. With regard to organic carbon, a major uncertainty is the net benefit of land use change given uncertainty about the quantity and quality of different forms of organic carbon resulting from different land uses. A major challenge is determining the flux of organic carbon from open systems like tidal wetlands. Converting present land uses to tidal wetlands will almost certainly result in increased methylation of mercury at the local scale with associated accumulation of mercury within local food webs. However, it is unclear if such local accumulation is of concern for fish, wildlife or humans at the local scale or if cumulative effects at the regional scale will emerge. Based on available information it is expected that restored tidal wetlands will remain stable once constructed; however, there is uncertainty associated with the available data regarding the balance of sediment accretion, sea-level rise, and sediment erosion. There is also uncertainty regarding the cumulative effect of many tidal restoration projects on sediment supply. The conclusions of the articles highlight the need to adopt a regional and multidisciplinary approach to tidal wetland restoration in the Estuary. The Science Program of the CALFED effort provides an appropriate venue for addressing these issues.

  15. Das inter-relações entre obra terminográfica, tema e público-alvo: elaborando a árvore de domínio de um vocabulário de Culinária para tradutores

    Directory of Open Access Journals (Sweden)

    Elisa Duarte Teixeira

    2016-03-01

    Full Text Available O presente trabalho visa discutir as implicações da escolha de um público-alvo específico – a saber, o tradutor – para o fazer terminológico de uma subárea específica: a Culinária. Após uma breve introdução à problemática discutida no artigo, os pressupostos teóricos do trabalho são apresentados e contrastados, com vistas a destacar sua relevância na metodologia de trabalho empregada. A análise foca nas subclasses semânticas dos Ingredientes e, a partir da árvore de domínio proposta, fazemos uma análise das definições e conceitos do campo semântico “tempero(s”. A análise dos dados aponta para a necessidade de se considerar, em vez das categorias clássicas comumente usadas para separar os semas genéricos dos específicos (definidos dicotomicamente com positivos ou negativos, uma estruturação sêmica de periferia fluida e permeável, representando um continuum de sentido que vai do mais prototípico (núcleo ao menos prototípico (margens – considerando-se numa dada área de especialidade e levando-se em conta um público-alvo específico.

  16. The construction of a revitalization program for the São Francisco River watershed

    OpenAIRE

    Machado, Antonio Thomaz da Mata

    2008-01-01

    A construção de um Programa de Revitalização da bacia do Rio São Francisco está em curso. Um decreto presidencial de 2001 e os Planos de Recursos Hídricos das bacias dos rios São Francisco e Velhas introduziram critérios e conceitos inovadores na definição de propostas para a recuperação hidroambiental de bacias hidrográficas. A polêmica em torno das obras de transposição de águas do Rio São Francisco e da implementação da lei das águas na bacia determina o processo de construção do programa....

  17. 76 FR 9709 - Water Quality Challenges in the San Francisco Bay/Sacramento-San Joaquin Delta Estuary

    Science.gov (United States)

    2011-02-22

    ... Water Quality Challenges in the San Francisco Bay/Sacramento-San Joaquin Delta Estuary AGENCY... the San Francisco Bay/ Sacramento-San Joaquin Delta Estuary (Bay Delta Estuary) in California. EPA is... programs to address recent significant declines in multiple aquatic species in the Bay Delta Estuary. EPA...

  18. 77 FR 32716 - Price for the 2012 American Eagle San Francisco Two-Coin Silver Proof Set

    Science.gov (United States)

    2012-06-01

    ... DEPARTMENT OF THE TREASURY United States Mint Price for the 2012 American Eagle San Francisco Two...: The United States Mint is announcing the price of the 2012 American Eagle San Francisco Two-Coin Silver Proof Set. The coin set will be offered for sale at a price of $149.95. FOR FURTHER INFORMATION...

  19. 76 FR 17752 - Notice of Intent To Prepare an Environmental Impact Statement for the San Francisco Veterans...

    Science.gov (United States)

    2011-03-30

    ... Environmental Policy Act (NEPA) of 1969, as amended, (42 U.S.C. 4331 et seq.), the Council on Environmental... the San Francisco Veterans Affairs Medical Center (SFVAMC) Institutional Master Plan AGENCY...: Comments should be addressed to John Pechman, Facility Planner, San Francisco VA Medical Center (001), 4150...

  20. Melhoramento do cafeeiro: IV - Café Mundo Novo

    Directory of Open Access Journals (Sweden)

    A. Carvalho

    1952-06-01

    Full Text Available Em um conjunto de cafeeiros existentes em Mundo Novo, hoje Urupês, na região Araraquarense do Estado de São Paulo, foram feitas seleções de vários cafeeiros baseando-se no seu aspecto vegetativo, na produção existente na época da seleção e na provável produção do ano seguinte. Estudou-se a origem da plantação inicial desse café, tanto em Urupês como em Jaú, chegando-se à conclusão de que é provavelmente originário desta última localidade. Progênies do café "Mundo Novo", anteriormente conhecido por "Sumatra" e derivado de plantas selecionadas em Urupês e Jaú, acham-se em estudo em seis localidades do Estado : Campinas, Ribeirão Prêto, Pindorama, Mococa, Jaú e Monte Alegre do Sul. No presente trabalho são apenas aproveitados dados referentes à variabilidade morfológica e característicos da produção das progênies dos primeiros cafeeiros selecionados em Urupês e estudados em Campinas, Jaú, Pindorama e Mococa. Em tôdas as localidades, observou-se variação nos caracteres morfológicos das progênies, verificando-se a ocorrência de plantas quase improdutivas. A maioria das progênies, no entanto, se caracteriza por acentuado vigor vegetativo. Foram estudadas as produções totais das progénies e das plantas, no período 1946-1951, notando-se que algumas progénies se salientaram pela elevada produção em tôdas as localidades. Os tipos de sementes "moca", "concha" e "chato" foram determinados em amostras de tôdas as plantas, por um período de três anos, notando-se que a variação ocorrida é da mesma ordem que a encontrada em outros cafeeiros em seleção. Procurou-se eliminar, pela seleção, cafeeiros com elevada produção de frutos sem sementes em uma ou duas lojas, característico êsse que parece ser hereditário. Os resultados obtidos de cruzamento entre os melhores cafeeiros "Mundo Novo" de Campinas e plantas da variedade murta, indicaram que esses cafeeiros são do tipo bourbon. Provavelmente

  1. Recurrence risk in de novo structural chromosomal rearrangements.

    Science.gov (United States)

    Röthlisberger, Benno; Kotzot, Dieter

    2007-08-01

    According to the textbook of Gardner and Sutherland [2004], the standard on genetic counseling for chromosome abnormalities, the recurrence risk of de novo structural or combined structural and numeric chromosome rearrangements is less than 0.5-2% and takes into account recurrence by chance, gonadal mosaicism, and somatic-gonadal mosaicism. However, these figures are roughly estimated and neither any systematic study nor exact or evidence-based risk calculations are available. To address this question, an extensive literature search was performed and surprisingly only 29 case reports of recurrence of de novo structural or combined structural and numeric chromosomal rearrangements were found. Thirteen of them were with a trisomy 21 due to an i(21q) replacing one normal chromosome 21. In eight of them low-level mosaicism in one of the parents was found either in fibroblasts or in blood or in both. As a consequence of the low number of cases and theoretical considerations (clinical consequences, mechanisms of formation, etc.), the recurrence risk should be reduced to less than 1% for a de novo i(21q) and to even less than 0.3% for all other de novo structural or combined structural and numeric chromosomal rearrangements. As the latter is lower than the commonly accepted risk of approximately 0.3% for indicating an invasive prenatal diagnosis and as the risk of abortion of a healthy fetus after chorionic villous sampling or amniocentesis is higher than approximately 0.5%, invasive prenatal investigation in most cases is not indicated and should only be performed if explicitly asked by the parents subsequent to appropriate genetic counseling. (c) 2007 Wiley-Liss, Inc.

  2. Novos encontros de anofelíneos em recipientes artificiais

    Directory of Open Access Journals (Sweden)

    Oswaldo Paulo Forattini

    1998-12-01

    Full Text Available Assinalam-se novos encontros de anofelíneos em recipientes artificiais. Um deles diz respeito a formas imaturas de Anopheles bellator em criadouros experimentais e outro é concernente ao achado de An. albitarsis l.s., em recipiente abandonado. Tecem-se considerações sobre a pressão seletiva representada pela produção, cada vez maior, de objetos descartáveis.

  3. Infant Mortality in Novo Hamburgo: Associated Factors and Cardiovascular Causes

    Energy Technology Data Exchange (ETDEWEB)

    Brum, Camila de Andrade [Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, RS (Brazil); Stein, Airton Tetelbom [Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS (Brazil); Grupo Hospitalar Conceição (GHC), Porto Alegre, RS (Brazil); Universidade Luterana do Brasil (ULBRA), Porto Alegre, RS (Brazil); Pellanda, Lucia Campos, E-mail: luciapell.pesquisa@cardiologia.org.br [Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, RS (Brazil); Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS (Brazil)

    2015-04-15

    Infant mortality has decreased in Brazil, but remains high as compared to that of other developing countries. In 2010, the Rio Grande do Sul state had the lowest infant mortality rate in Brazil. However, the municipality of Novo Hamburgo had the highest infant mortality rate in the Porto Alegre metropolitan region. To describe the causes of infant mortality in the municipality of Novo Hamburgo from 2007 to 2010, identifying which causes were related to heart diseases and if they were diagnosed in the prenatal period, and to assess the access to healthcare services. This study assessed infants of the municipality of Novo Hamburgo, who died, and whose data were collected from the infant death investigation records. Of the 157 deaths in that period, 35.3% were reducible through diagnosis and early treatment, 25% were reducible through partnership with other sectors, 19.2% were non-preventable, 11.5% were reducible by means of appropriate pregnancy monitoring, 5.1% were reducible through appropriate delivery care, and 3.8% were ill defined. The major cause of death related to heart disease (13.4%), which was significantly associated with the variables ‘age at death’, ‘gestational age’ and ‘birth weight’. Regarding access to healthcare services, 60.9% of the pregnant women had a maximum of six prenatal visits. It is mandatory to enhance prenatal care and newborn care at hospitals and basic healthcare units to prevent infant mortality.

  4. Infant Mortality in Novo Hamburgo: Associated Factors and Cardiovascular Causes

    Directory of Open Access Journals (Sweden)

    Camila de Andrade Brum

    2015-04-01

    Full Text Available Background: Infant mortality has decreased in Brazil, but remains high as compared to that of other developing countries. In 2010, the Rio Grande do Sul state had the lowest infant mortality rate in Brazil. However, the municipality of Novo Hamburgo had the highest infant mortality rate in the Porto Alegre metropolitan region. Objective: To describe the causes of infant mortality in the municipality of Novo Hamburgo from 2007 to 2010, identifying which causes were related to heart diseases and if they were diagnosed in the prenatal period, and to assess the access to healthcare services. Methods: This study assessed infants of the municipality of Novo Hamburgo, who died, and whose data were collected from the infant death investigation records. Results: Of the 157 deaths in that period, 35.3% were reducible through diagnosis and early treatment, 25% were reducible through partnership with other sectors, 19.2% were non-preventable, 11.5% were reducible by means of appropriate pregnancy monitoring, 5.1% were reducible through appropriate delivery care, and 3.8% were ill defined. The major cause of death related to heart disease (13.4%, which was significantly associated with the variables ‘age at death’, ‘gestational age’ and ‘birth weight’. Regarding access to healthcare services, 60.9% of the pregnant women had a maximum of six prenatal visits. Conclusion: It is mandatory to enhance prenatal care and newborn care at hospitals and basic healthcare units to prevent infant mortality.

  5. Generative Recurrent Networks for De Novo Drug Design.

    Science.gov (United States)

    Gupta, Anvita; Müller, Alex T; Huisman, Berend J H; Fuchs, Jens A; Schneider, Petra; Schneider, Gisbert

    2018-01-01

    Generative artificial intelligence models present a fresh approach to chemogenomics and de novo drug design, as they provide researchers with the ability to narrow down their search of the chemical space and focus on regions of interest. We present a method for molecular de novo design that utilizes generative recurrent neural networks (RNN) containing long short-term memory (LSTM) cells. This computational model captured the syntax of molecular representation in terms of SMILES strings with close to perfect accuracy. The learned pattern probabilities can be used for de novo SMILES generation. This molecular design concept eliminates the need for virtual compound library enumeration. By employing transfer learning, we fine-tuned the RNN's predictions for specific molecular targets. This approach enables virtual compound design without requiring secondary or external activity prediction, which could introduce error or unwanted bias. The results obtained advocate this generative RNN-LSTM system for high-impact use cases, such as low-data drug discovery, fragment based molecular design, and hit-to-lead optimization for diverse drug targets. © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  6. Infant Mortality in Novo Hamburgo: Associated Factors and Cardiovascular Causes

    International Nuclear Information System (INIS)

    Brum, Camila de Andrade; Stein, Airton Tetelbom; Pellanda, Lucia Campos

    2015-01-01

    Infant mortality has decreased in Brazil, but remains high as compared to that of other developing countries. In 2010, the Rio Grande do Sul state had the lowest infant mortality rate in Brazil. However, the municipality of Novo Hamburgo had the highest infant mortality rate in the Porto Alegre metropolitan region. To describe the causes of infant mortality in the municipality of Novo Hamburgo from 2007 to 2010, identifying which causes were related to heart diseases and if they were diagnosed in the prenatal period, and to assess the access to healthcare services. This study assessed infants of the municipality of Novo Hamburgo, who died, and whose data were collected from the infant death investigation records. Of the 157 deaths in that period, 35.3% were reducible through diagnosis and early treatment, 25% were reducible through partnership with other sectors, 19.2% were non-preventable, 11.5% were reducible by means of appropriate pregnancy monitoring, 5.1% were reducible through appropriate delivery care, and 3.8% were ill defined. The major cause of death related to heart disease (13.4%), which was significantly associated with the variables ‘age at death’, ‘gestational age’ and ‘birth weight’. Regarding access to healthcare services, 60.9% of the pregnant women had a maximum of six prenatal visits. It is mandatory to enhance prenatal care and newborn care at hospitals and basic healthcare units to prevent infant mortality

  7. Health, Traffic, and Environmental Justice: Collaborative Research and Community Action in San Francisco, California

    Science.gov (United States)

    Sciammas, Charlie; Seto, Edmund; Bhatia, Rajiv; Rivard, Tom

    2009-01-01

    Health impacts on neighborhood residents from transportation systems can be an environmental justice issue. To assess the effects of transportation planning decisions, including the construction of an intraurban freeway, on residents of the Excelsior neighborhood in southeast San Francisco, PODER (People Organizing to Demand Environmental and Economic Rights), a local grassroots environmental justice organization; the San Francisco Department of Public Health; and the University of California, Berkeley, collaborated on participatory research. We used our findings regarding traffic-related exposures and health hazards in the area to facilitate community education and action to address transportation-related health burdens on neighborhood residents. PMID:19890147

  8. Crustal structure of the coastal and marine San Francisco Bay region, California

    Science.gov (United States)

    Parsons, Tom

    2002-01-01

    As of the time of this writing, the San Francisco Bay region is home to about 6.8 million people, ranking fifth among population centers in the United States. Most of these people live on the coastal lands along San Francisco Bay, the Sacramento River delta, and the Pacific coast. The region straddles the tectonic boundary between the Pacific and North American Plates and is crossed by several strands of the San Andreas Fault system. These faults, which are stressed by about 4 cm of relative plate motion each year, pose an obvious seismic hazard.

  9. Anthropogenic influences on shoreline and nearshore evolution in the San Francisco Bay coastal system

    Science.gov (United States)

    Dallas, K.L.; Barnard, P.L.

    2011-01-01

    Analysis of four historical bathymetric surveys over a 132-year period has revealed significant changes to the morphology of the San Francisco Bar, an ebb-tidal delta at the mouth of San Francisco Bay estuary. From 1873 to 2005 the San Francisco Bar vertically-eroded an average of 80 cm over a 125 km2 area, which equates to a total volume loss of 100 ± 52 million m3 of fine- to coarse-grained sand. Comparison of the surveys indicates the entire ebb-tidal delta contracted radially, with the crest moving landward an average of 1 km. Long-term erosion of the ebb-tidal delta is hypothesized to be due to a reduction in the tidal prism of San Francisco Bay and a decrease in coastal sediment supply, both as a result of anthropogenic activities. Prior research indicates that the tidal prism of the estuary was reduced by 9% from filling, diking, and sedimentation. Compilation of historical records dating back to 1900 reveals that a minimum of 200 million m3 of sediment has been permanently removed from the San Francisco Bay coastal system through dredging, aggregate mining, and borrow pit mining. Of this total, ~54 million m3 of sand-sized or coarser sediment was removed from central San Francisco Bay. With grain sizes comparable to the ebb-tidal delta, and its direct connection to the bay mouth, removal of sediments from central San Francisco Bay may limit the sand supply to the delta and open coast beaches. SWAN wave modeling illustrates that changes to the morphology of the San Francisco Bar have altered the alongshore wave energy distribution at adjacent Ocean Beach, and thus may be a significant factor in a persistent beach erosion ‘hot spot’ occurring in the area. Shoreline change analyses show that the sandy shoreline in the shadow of the ebb-tidal delta experienced long-term (1850s/1890s to 2002) and short-term (1960s/1980s to 2002) accretion while the adjacent sandy shoreline exposed to open-ocean waves experienced long-term and short-term erosion. Therefore

  10. Web Access to Digitised Content of the Exhibition Novo Mesto 1848-1918 at the Dolenjska Museum, Novo Mesto

    Directory of Open Access Journals (Sweden)

    Majda Pungerčar

    2013-09-01

    Full Text Available EXTENDED ABSTRACTFor the first time, the Dolenjska museum Novo mesto provided access to digitised museum resources when they took the decision to enrich the exhibition Novo mesto 1848-1918 by adding digital content. The following goals were identified: the digital content was created at the time of exhibition planning and design, it met the needs of different age groups of visitors, and during the exhibition the content was accessible via touch screen. As such, it also served for educational purposes (content-oriented lectures or problem solving team work. In the course of exhibition digital content was accessible on the museum website http://www.novomesto1848-1918.si. The digital content was divided into the following sections: the web photo gallery, the quiz and the game. The photo gallery was designed in the same way as the exhibition and the print catalogue and extended by the photos of contemporary Novo mesto and accompanied by the music from the orchestron machine. The following themes were outlined: the Austrian Empire, the Krka and Novo mesto, the town and its symbols, images of the town and people, administration and economy, social life and Novo mesto today followed by digitised archive materials and sources from that period such as the Commemorative book of the Uniformed Town Guard, the National Reading Room Guest Book, the Kazina guest book, the album of postcards and the Diploma of Honoured Citizen Josip Gerdešič. The Web application was also a tool for a simple and on line selection of digitised material and the creation of new digital content which proved to be much more convenient for lecturing than Power Point presentations. The quiz consisted of 40 questions relating to the exhibition theme and the catalogue. Each question offered a set of three answers only one of them being correct and illustrated by photography. The application auto selected ten questions and valued the answers immediately. The quiz could be accessed

  11. City College of San Francisco 1997 Sexual Harassment Student Opinion Survey.

    Science.gov (United States)

    City Coll. of San Francisco, CA. Office of Institutional Research, Planning and Grants.

    This document describes the findings of a 1997 sexual harassment student opinion survey conducted at City College of San Francisco. Survey questions were jointly developed by the Sexual Harassment Prevention Sub-Committee of the Diversity Advisory Committee and the Office of Research and Planning, approved by the College Advisory Council, and…

  12. 33 CFR 165.1192 - Security Zones; Waters surrounding San Francisco International Airport and Oakland International...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zones; Waters..., California. 165.1192 Section 165.1192 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Security Zones; Waters surrounding San Francisco International Airport and Oakland International Airport...

  13. Stratigraphical analysis of the neoproterozoic sedimentary sequences of the Sao Francisco Basin

    International Nuclear Information System (INIS)

    Martins, Mariela; Lemos, Valesca Brasil

    2007-01-01

    A stratigraphic analysis was performed under the principles of Sequence Stratigraphy on the neoproterozoic sedimentary sequences of the Sao Francisco Basin (Central Brazil). Three periods of deposition separated by unconformities were recognized in the Sao Francisco Megasequence: (1) Sequences 1 and 2, a cryogenian glaciogenic sequence, followed by a distal scarp carbonate ramp, developed during stable conditions, (2) Sequence 3, a Upper Cryogenian stack homoclinal ramps with mixed carbonate-siliciclastic sedimentation, deposited under a progressive influence of compressional stresses of the Brasiliano Cycle, (3) Sequence 4, a Lower Ediacaran shallow platform dominated by siliciclastic sedimentation of molassic nature, the erosion product of the nearby uplifted thrust sheets. Each of the carbonate-bearing sequences presents a distinct δ 13 C isotopic signature. The superposition to the global curve for carbon isotopic variation allowed the recognition of a major depositional hiatus between the Paranoa and Sao Francisco Megasequences, and suggested that the glacial diamictite deposition (Jequitai Formation) took place most probably around 800 Ma. This constrains the Sao Francisco Megasequence deposition to the interval between 800 and 600 Ma (the known ages of the Brasiliano Orogeny defines the upper limit). A minor depositional hiatus (700.680 Ma) was also identified separating sequences 2 and 3. Isotopic analyses suggest that from then on, more restricted environmental conditions were established in the basin, probably associated with a first order global event, which prevailed throughout deposition of the Sequence 3. (author)

  14. 33 CFR 165.1190 - Security Zone; San Francisco Bay, Oakland Estuary, Alameda, CA.

    Science.gov (United States)

    2010-07-01

    ..., Oakland Estuary, Alameda, CA. 165.1190 Section 165.1190 Navigation and Navigable Waters COAST GUARD... § 165.1190 Security Zone; San Francisco Bay, Oakland Estuary, Alameda, CA. (a) Location. The following area is a security zone: All navigable waters of the Oakland Estuary, California, from the surface to...

  15. 33 CFR 167.405 - Off San Francisco: Main ship channel.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Off San Francisco: Main ship channel. 167.405 Section 167.405 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas...

  16. 76 FR 55261 - Safety Zone; Corporate Party on Hornblower Yacht, San Francisco, CA

    Science.gov (United States)

    2011-09-07

    ...-AA00 Safety Zone; Corporate Party on Hornblower Yacht, San Francisco, CA AGENCY: Coast Guard, DHS... Corporate Party on Hornblower Yacht. This temporary safety zone is established to ensure the safety of... Events will sponsor the Corporate Party on Hornblower Yacht on September 17, 2011, in the navigable...

  17. The Quality Teacher and Education Act in San Francisco: Lessons Learned. Policy Brief 09-2

    Science.gov (United States)

    Hough, Heather J.

    2009-01-01

    This policy brief reviews the recent experience of the San Francisco Unified School District (SFUSD) with the development and approval of Proposition A. Proposition A (also known as the Quality Teacher and Education Act, or QTEA) included a parcel tax mainly dedicated to increasing teachers' salaries, along with a variety of measures introducing…

  18. Dogs Are Talking: San Francisco's social marketing campaign to increase syphilis screening.

    Science.gov (United States)

    Stephens, Sally C; Bernstein, Kyle T; McCright, Jacqueline E; Klausner, Jeffrey D

    2010-03-01

    To promote regular syphilis testing among men who have sex with men in San Francisco, a social marketing campaign, Dogs Are Talking, was created. An evaluation of the campaign found no difference in syphilis testing among men who recalled the campaign and those that did not. A significant difference was seen among HIV-infected men.

  19. Making Whites from the Dark Side: Teaching Whiteness Studies at San Francisco State University

    Science.gov (United States)

    Sueyoshi, Amy

    2013-01-01

    While whiteness studies at most institutions aims to expose the persistence of white supremacy to a disbelieving audience, whiteness studies within the College of Ethnic Studies (COES) at San Francisco State University (SFSU) begins with the assumption that racism still exists. The course then traces how whiteness is constructed and fortified to…

  20. 78 FR 40396 - Safety Zone; America's Cup Safety Zone and No Loitering Area, San Francisco, CA

    Science.gov (United States)

    2013-07-05

    ...-AA00 Safety Zone; America's Cup Safety Zone and No Loitering Area, San Francisco, CA AGENCY: Coast... America's Cup races. This safety zone and no loitering area are established to enhance the safety of spectators and mariners near the north east corner of the America's Cup regulated area. All persons or...

  1. Travel and Tourism Industry: Program Options for City College of San Francisco.

    Science.gov (United States)

    City Coll. of San Francisco, CA.

    In an effort to determine the current occupational outlook and resulting implications for education and training, the City College of San Francisco (CCSF), in California, undertook a study of current trends in the travel and tourism industry. This report provides findings from the project, which involved consultation with local and national…

  2. Realizing a Progressive Pedagogy: A Comparative Case Study of Two Reggio Emilia Preschools in San Francisco

    Science.gov (United States)

    Abdelfattah, Marwa

    2015-01-01

    This study aims to uncover how a particular imported philosophy of early childhood education, Reggio Emilia, is implemented in the context of one public and one private preschool in San Francisco. The philosophy of Reggio Emilia is believed to be progressive and to be developmentally appropriate for children in early childhood. The study involved…

  3. Communications and Collaboration Keep San Francisco VA Medical Center Project on Track

    International Nuclear Information System (INIS)

    Federal Energy Management Program

    2001-01-01

    This case study about energy saving performance contacts (ESPCs) presents an overview of how the Veterans Affairs Medical Center in San Francisco established an ESPC contract and the benefits derived from it. The Federal Energy Management Program instituted these special contracts to help federal agencies finance energy-saving projects at their facilities

  4. CAREER TRAINING IN HOTEL AND RESTAURANT OPERATION...AT CITY COLLEGE OF SAN FRANCISCO.

    Science.gov (United States)

    BATMALE, LOUIS F.; MULLANY, GEORGE G.

    THE HOTEL AND RESTAURANT PROGRAM, ONE OF 35 SEMIPROFESSIONAL TRAINING PROGRAMS AT CITY COLLEGE OF SAN FRANCISCO, COMBINES GENERAL EDUCATION, RELATED BUSINESS INSTRUCTION, HOTEL AND RESTAURANT CLASSES, FOOD PREPARATION AND SERVICE TRAINING, AND WORK EXPERIENCE. THIS DESCRIPTION OF THE PROGRAM INCLUDES (1) PURPOSES AND OBJECTIVES, (2) CURRICULUM,…

  5. 78 FR 75249 - Safety Zone: Google's Night at Sea Fireworks Display, San Francisco Bay, Alameda, CA

    Science.gov (United States)

    2013-12-11

    ...-AA00 Safety Zone: Google's Night at Sea Fireworks Display, San Francisco Bay, Alameda, CA AGENCY: Coast... Google's Night at Sea Fireworks Displays on December 7, 2013 and December 14, 2013. These safety zones... Coast Guard to establish safety zones. Google will sponsor the Google's Night at Sea Fireworks Displays...

  6. De novo assembly of highly diverse viral populations

    Directory of Open Access Journals (Sweden)

    Yang Xiao

    2012-09-01

    Full Text Available Abstract Background Extensive genetic diversity in viral populations within infected hosts and the divergence of variants from existing reference genomes impede the analysis of deep viral sequencing data. A de novo population consensus assembly is valuable both as a single linear representation of the population and as a backbone on which intra-host variants can be accurately mapped. The availability of consensus assemblies and robustly mapped variants are crucial to the genetic study of viral disease progression, transmission dynamics, and viral evolution. Existing de novo assembly techniques fail to robustly assemble ultra-deep sequence data from genetically heterogeneous populations such as viruses into full-length genomes due to the presence of extensive genetic variability, contaminants, and variable sequence coverage. Results We present VICUNA, a de novo assembly algorithm suitable for generating consensus assemblies from genetically heterogeneous populations. We demonstrate its effectiveness on Dengue, Human Immunodeficiency and West Nile viral populations, representing a range of intra-host diversity. Compared to state-of-the-art assemblers designed for haploid or diploid systems, VICUNA recovers full-length consensus and captures insertion/deletion polymorphisms in diverse samples. Final assemblies maintain a high base calling accuracy. VICUNA program is publicly available at: http://www.broadinstitute.org/scientific-community/science/projects/viral-genomics/ viral-genomics-analysis-software. Conclusions We developed VICUNA, a publicly available software tool, that enables consensus assembly of ultra-deep sequence derived from diverse viral populations. While VICUNA was developed for the analysis of viral populations, its application to other heterogeneous sequence data sets such as metagenomic or tumor cell population samples may prove beneficial in these fields of research.

  7. Tradução, padrões e nuances: um estudo de Linguística de Corpus sobre diferentes prosódias semânticas na língua fonte e na língua alvo Translation, patterns and nuance: a study based on Corpus Linguistics about different semantic prosodies found in the source and target languages

    Directory of Open Access Journals (Sweden)

    Maria Cecília Lopes

    2011-01-01

    Full Text Available Neste artigo propomos uma discussão sobre a importância da prosódia semântica em traduções. Para tanto, estudamos sete itens lexicais analisados anteriormente por Coterril (2001, em inglês, que também ocorreram nos 162 textos jornalísticos do corpus paralelo desta pesquisa, formado por dados originalmente escritos em inglês (língua fonte e traduzidos para o português (língua-alvo. As ferramentas Alinhador, Concordanciador Paralelo (CEPRIL, LAEL, PUC-SP e WordSmith Tools 4 (SCOTT, 2004 foram usadas para a organização e o processamento dos dados. Como corpus de referência usou-se o Corpus do Português (DAVIES; FERREIRA, 2008. A análise mostrou resultados diferentes entre as prosódias semânticas de itens usados na língua fonte e na língua-alvo sugerindo que as escolhas tradutórias não imprimem o mesmo sentido do original. Concluimos este artigo sinalizando para a importância de estudos bilíngues que descrevam padrões lexicogramaticais, como a prosódia semântica, de maneira a contribuir para o estudo e a prática de tradução.This article aims to discuss the importance of semantic prosody in translation. Therefore, we present the analysis of seven lexical items previously studied in English by Coterril (2001 which also occurred in our parallel corpus (English-Portuguese composed by 162 journalistic texts. The methodology included data submitted to Alinhador Paralelo, Concordanciador Paralelo (CEPRIL, LAEL, PUC-SP and WordSmith Tools 4 (SCOTT, 2004. Corpus do Português (DAVIES; FERREIRA, 2008 was used as a reference corpus. The results showed different semantic prosody when comparing the itens used in the source and target languages (English-Portuguese. In our conclusion we offer some suggestions for future research considering two languages when investigating lexicogrammatical patterns such as the semantic prosody for Translation studies and practice.

  8. Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia.

    Science.gov (United States)

    Armas, Aristides; Chen, Chen; Mims, Martha; Rivero, Gustavo

    2017-01-01

    Myelodysplastic syndrome (MDS) is cytogenetically heterogeneous and retains variable risk for acute myeloid leukemia transformation. Though not yet fully understood, there is an association between genetic abnormalities and defects in gene expression. The functional role for infrequent cytogenetic alteration remains unclear. An uncommon chromosomic abnormality is the presence of the Philadelphia (Ph) chromosome. Here, we report a patient with Ph+ MDS treated with low dose Dasatinib who achieved hematologic response for 7 months. In addition, we also examined the English literature on all de novo Ph + MDS cases between 1996 and 2015 to gain insight into clinical features and outcome.

  9. Perspective on Biotransformation and De Novo Biosynthesis of Licorice Constituents.

    Science.gov (United States)

    Zhao, Yujia; Lv, Bo; Feng, Xudong; Li, Chun

    2017-12-27

    Licorice, an important herbal medicine, is derived from the dried roots and rhizomes of Glycyrrhiza genus plants. It has been widely used in food, pharmaceutical, tobacco, and cosmetics industries with high economic value. However, overexploitation of licorice resources has severely destroyed the local ecology. Therefore, producing bioactive compounds of licorice through the biotransformation and bioengineering methods is a hot spot in recent years. In this perspective, we comprehensively summarize the biotransformation of licorice constituents into high-value-added derivatives by biocatalysts. Furthermore, successful cases and the strategies for de novo biosynthesizing compounds of licorice in microbes have been summarized. This paper will provide new insights for the further research of licorice.

  10. De Novo and Recurrence of Nonalcoholic Steatohepatitis After Liver Transplantation.

    Science.gov (United States)

    Kappus, Matthew; Abdelmalek, Manal

    2017-05-01

    Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developing countries. Approximately 25% of patients with NAFLD develop nonalcoholic steatohepatitis (NASH). NASH-related cirrhosis is now a leading listing indication for liver transplantation in the United States. Although posttransplant survival for NASH-related cirrhosis is comparable with that of other liver diseases, many patients have features of metabolic syndrome, which can contribute to a recurrence of NAFLD or NASH. This article reviews the epidemiology, pathophysiology, and treatment of de novo and recurrence of NASH after liver transplantation. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. The historical town core and traffic in Novo mesto

    Directory of Open Access Journals (Sweden)

    Lilijana Jankovič

    2001-01-01

    Full Text Available The historical town core of Novo mesto is subject to intolerable traffic conditions. Individual car use is suffocating the town core, but simultaneously good access is essential for shopkeepers and other inhabitants since buses don’t go there. The project proposes changes to the traffic regime, its basic goals are to redesign the town square into a pedestrian place and to eliminate transitory traffic by rerouting vehicles to less burdened side roads. It introduces short-term parking, smaller parking garages in the core and larger parking spaces on the edge and routes the buses through the town core.

  12. Model-Based GUI Testing Using Uppaal at Novo Nordisk

    Science.gov (United States)

    Hjort, Ulrik H.; Illum, Jacob; Larsen, Kim G.; Petersen, Michael A.; Skou, Arne

    This paper details a collaboration between Aalborg University and Novo Nordiskin developing an automatic model-based test generation tool for system testing of the graphical user interface of a medical device on an embedded platform. The tool takes as input an UML Statemachine model and generates a test suite satisfying some testing criterion, such as edge or state coverage, and converts the individual test case into a scripting language that can be automatically executed against the target. The tool has significantly reduced the time required for test construction and generation, and reduced the number of test scripts while increasing the coverage.

  13. Novo-desenvolvimento, capital social e desigualdade social

    Directory of Open Access Journals (Sweden)

    Ana Cristina de Oliveira Oliveira

    2012-03-01

    Full Text Available Este artigo aborda a tendência de enfrentamento da desigualdade social a partir, no campo econômico, da versão do novo-desenvolvimentismo e, no campo político e ideológico, a partir da noção de capital social, na tentativa de realizar um "capitalismo com face mais humana". Discutiremos duas ordens de questões, considerando a especificidade da formação social brasileira de capitalismo dependente: 1 a “construção de Estados fortes” para

    assegurar as condições de acumulação do capital, ampliando as margens do mercado de consumo, aliviando a pobreza e controlando possíveis tensões políticas e 2 a difusão da necessidade de construir uma sociedade em harmonia, que se traduz na incorporação da ética empreendedora dos empresários em todas as esferas sociais. Entendemos que este escopo político-econômico revela uma nova pedagogia da hegemonia, sustentada numa suposta alternativa
    de gerenciamento das novas expressões da “questão social”, voltada para educar o conformismo e ocultar o conflito de classes.
    Palavras-chave:  questão social; novo-desenvolvimentismo; capital social; inclusão forçada

  14. De novo biosynthesis of anthocyanins in Saccharomyces cerevisiae.

    Science.gov (United States)

    Eichenberger, Michael; Hansson, Anders; Fischer, David; Dürr, Lara; Naesby, Michael

    2018-06-01

    Anthocyanins (ACNs) are plant secondary metabolites responsible for most of the red, purple and blue colors of flowers, fruits and vegetables. They are increasingly used in the food and beverage industry as natural alternative to artificial colorants. Production of these compounds by fermentation of microorganisms would provide an attractive alternative. In this study, Saccharomyces cerevisiae was engineered for de novo production of the three basic anthocyanins, as well as the three main trans-flavan-3-ols. Enzymes from different plant sources were screened and efficient variants found for most steps of the biosynthetic pathway. However, the anthocyanidin synthase was identified as a major obstacle to efficient production. In yeast, this enzyme converts the majority of its natural substrates leucoanthocyanidins into the off-pathway flavonols. Nonetheless, de novo biosynthesis of ACNs was shown for the first time in yeast and for the first time in a single microorganism. It provides a framework for optimizing the activity of anthocyanidin synthase and represents an important step towards sustainable industrial production of these highly relevant molecules in yeast.

  15. Origins of De Novo Genes in Human and Chimpanzee.

    Science.gov (United States)

    Ruiz-Orera, Jorge; Hernandez-Rodriguez, Jessica; Chiva, Cristina; Sabidó, Eduard; Kondova, Ivanela; Bontrop, Ronald; Marqués-Bonet, Tomàs; Albà, M Mar

    2015-12-01

    The birth of new genes is an important motor of evolutionary innovation. Whereas many new genes arise by gene duplication, others originate at genomic regions that did not contain any genes or gene copies. Some of these newly expressed genes may acquire coding or non-coding functions and be preserved by natural selection. However, it is yet unclear which is the prevalence and underlying mechanisms of de novo gene emergence. In order to obtain a comprehensive view of this process, we have performed in-depth sequencing of the transcriptomes of four mammalian species--human, chimpanzee, macaque, and mouse--and subsequently compared the assembled transcripts and the corresponding syntenic genomic regions. This has resulted in the identification of over five thousand new multiexonic transcriptional events in human and/or chimpanzee that are not observed in the rest of species. Using comparative genomics, we show that the expression of these transcripts is associated with the gain of regulatory motifs upstream of the transcription start site (TSS) and of U1 snRNP sites downstream of the TSS. In general, these transcripts show little evidence of purifying selection, suggesting that many of them are not functional. However, we find signatures of selection in a subset of de novo genes which have evidence of protein translation. Taken together, the data support a model in which frequently-occurring new transcriptional events in the genome provide the raw material for the evolution of new proteins.

  16. A simple method suitable to study de novo root organogenesis

    Directory of Open Access Journals (Sweden)

    Xiaodong eChen

    2014-05-01

    Full Text Available De novo root organogenesis is the process in which adventitious roots regenerate from detached or wounded plant tissues or organs. In tissue culture, appropriate types and concentrations of plant hormones in the medium are critical for inducing adventitious roots. However, in natural conditions, regeneration from detached organs is likely to rely on endogenous hormones. To investigate the actions of endogenous hormones and the molecular mechanisms guiding de novo root organogenesis, we developed a simple method to imitate natural conditions for adventitious root formation by culturing Arabidopsis thaliana leaf explants on B5 medium without additive hormones. Here we show that the ability of the leaf explants to regenerate roots depends on the age of the leaf and on certain nutrients in the medium. Based on these observations, we provide examples of how this method can be used in different situations, and how it can be optimized. This simple method could be used to investigate the effects of various physiological and molecular changes on the regeneration of adventitious roots. It is also useful for tracing cell lineage during the regeneration process by differential interference contrast observation of -glucuronidase staining, and by live imaging of proteins labeled with fluorescent tags.

  17. De novo transcriptome assembly of Setatria italica variety Taejin

    Directory of Open Access Journals (Sweden)

    Yeonhwa Jo

    2016-06-01

    Full Text Available Foxtail millet (Setaria italica belonging to the family Poaceae is an important millet that is widely cultivated in East Asia. Of the cultivated millets, the foxtail millet has the longest history and is one of the main food crops in South India and China. Moreover, foxtail millet is a model plant system for biofuel generation utilizing the C4 photosynthetic pathway. In this study, we carried out de novo transcriptome assembly for the foxtail millet variety Taejin collected from Korea using next-generation sequencing. We obtained a total of 8.676 GB raw data by paired-end sequencing. The raw data in this study can be available in NCBI SRA database with accession number of SRR3406552. The Trinity program was used to de novo assemble 145,332 transcripts. Using the TransDecoder program, we predicted 82,925 putative proteins. BLASTP was performed against the Swiss-Prot protein sequence database to annotate the functions of identified proteins, resulting in 20,555 potentially novel proteins. Taken together, this study provides transcriptome data for the foxtail millet variety Taejin by RNA-Seq.

  18. De novo transcriptome assembly of the mycoheterotrophic plant Monotropa hypopitys

    Directory of Open Access Journals (Sweden)

    Alexey V. Beletsky

    2017-03-01

    Full Text Available Monotropa hypopitys (pinesap is a non-photosynthetic obligately mycoheterotrophic plant of the family Ericaceae. It obtains the carbon and other nutrients from the roots of surrounding autotrophic trees through the associated mycorrhizal fungi. In order to understand the evolutionary changes in the plant genome associated with transition to a heterotrophic lifestyle, we performed de novo transcriptomic analysis of M. hypopitys using next-generation sequencing. We obtained the RNA-Seq data from flowers, flower bracts and roots with haustoria using Illumina HiSeq2500 platform. The raw data obtained in this study can be available in NCBI SRA database with accession number of SRP069226. A total of 10.3 GB raw sequence data were obtained, corresponding to 103,357,809 raw reads. A total of 103,025,683 reads were filtered after removing low-quality reads and trimming the adapter sequences. The Trinity program was used to de novo assemble 98,349 unigens with an N50 of 1342 bp. Using the TransDecoder program, we predicted 43,505 putative proteins. 38,416 unigenes were annotated in the Swiss-Prot protein sequence database using BLASTX. The obtained transcriptomic data will be useful for further studies of the evolution of plant genomes upon transition to a non-photosynthetic lifestyle and the loss of photosynthesis-related functions.

  19. A distribuição das transferências, público-alvo e cobertura do Benefício de Prestação Continuada = The Distribution of transfers, target-group and coverage of the Continuous Cash Benefit

    Directory of Open Access Journals (Sweden)

    Medeiros, Marcelo

    2009-01-01

    Full Text Available O artigo propõe uma nova definição operacional de deficiência e uma metodologia de cálculo para estimar as distribuições de pessoas idosas e deficientes incapazes para o trabalho e vida independente, dos benefícios e dos níveis de cobertura do Benefício de Prestação Continuada (BPC, segundo diferentes estratos de renda da população brasileira. São usados dados do Censo 2000, da Pnad 2006 e de registros administrativos do MDS. A estimativa indica que a população de idosos e deficientes incapazes distribui-se uniformemente nos estratos de renda, mas os benefícios são distribuídos predominantemente nos grupos de renda mais baixa da população, com a cobertura maior entre os mais pobres. Os resultados sugerem que a cobertura da população-alvo ainda é insuficiente e que o programa apresenta erros de focalização, mas estes são, em sua maioria, de baixa intensidade

  20. 77 FR 43161 - Special Local Regulation; San Francisco Bay Navy Fleetweek Parade of Ships and Blue Angels...

    Science.gov (United States)

    2012-07-24

    .... 3. Privacy Act Anyone can search the electronic form of comments received into any of our dockets by... tactical coxswains from Sector San Francisco's boat stations, has led the Coast Guard to determine that a...

  1. Environmental Sensitivity Index (ESI) Atlas: San Francisco Bay - 1998, maps and geographic information systems data (NODC Accession 0036884)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) maps for the shoreline of San Francisco Bay. ESI data characterize estuarine environments and...

  2. Environmental Sensitivity Index (ESI) Atlas: San Francisco Bay, California maps and geographic information systems data (NODC Accession 0013224)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set comprises the Environmental Sensitivity Index (ESI) maps for the shoreline of San Francisco Bay. ESI data characterize estuarine environments and...

  3. Metropolitan Transportation Commission, San Francisco Bay area : developing regional objectives and performance measures to improve system operations

    Science.gov (United States)

    2009-04-01

    The Metropolitan Transportation Commission (MTC) uses an objectives-driven, performance-based approach in its transportation planning for the San Francisco Bay Area. This approach focuses attention on transportation investments of highest priority. T...

  4. Uudised : Neeme Järvi San Franciscos. Tõnis Mägi Moskvas. TMKK Norras ja Ungaris / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2000-01-01

    N. Järvi juhatab San Francisco Ooperis Rimski-Korsakovi ooperit "Tsaari mõrsja", esietendus 11. sept. T. Mägi esines 1. sept. Eesti Suursaatkonnas Moskvas. TMKK Kammerkoori kontsertreisidest Norrasse ja Ungarisse

  5. Combined "de novo" and "ex novo" lipid fermentation in a mix-medium of corncob acid hydrolysate and soybean oil by Trichosporon dermatis.

    Science.gov (United States)

    Huang, Chao; Luo, Mu-Tan; Chen, Xue-Fang; Qi, Gao-Xiang; Xiong, Lian; Lin, Xiao-Qing; Wang, Can; Li, Hai-Long; Chen, Xin-De

    2017-01-01

    Microbial oil is one important bio-product for its important function in energy, chemical, and food industry. Finding suitable substrates is one key issue for its industrial application. Both hydrophilic and hydrophobic substrates can be utilized by oleaginous microorganisms with two different bio-pathways (" de novo " lipid fermentation and " ex novo " lipid fermentation). To date, most of the research on lipid fermentation has focused mainly on only one fermentation pathway and little work was carried out on both " de novo " and " ex novo " lipid fermentation simultaneously; thus, the advantages of both lipid fermentation cannot be fulfilled comprehensively. In this study, corncob acid hydrolysate with soybean oil was used as a mix-medium for combined " de novo " and " ex novo " lipid fermentation by oleaginous yeast Trichosporon dermatis . Both hydrophilic and hydrophobic substrates (sugars and soybean oil) in the medium can be utilized simultaneously and efficiently by T. dermatis . Different fermentation modes were compared and the batch mode was the most suitable for the combined fermentation. The influence of soybean oil concentration, inoculum size, and initial pH on the lipid fermentation was evaluated and 20 g/L soybean oil, 5% inoculum size, and initial pH 6.0 were suitable for this bioprocess. By this technology, the lipid composition of extracellular hydrophobic substrate (soybean oil) can be modified. Although adding emulsifier showed little beneficial effect on lipid production, it can modify the intracellular lipid composition of T. dermatis . The present study proves the potential and possibility of combined " de novo " and " ex novo " lipid fermentation. This technology can use hydrophilic and hydrophobic sustainable bio-resources to generate lipid feedstock for the production of biodiesel or other lipid-based chemical compounds and to treat some special wastes such as oil-containing wastewater.

  6. Precarious City: Marginal Workers, The State, And Working-Class Activism In Post-Industrial San Francisco, 1964-1979

    OpenAIRE

    Martin, Laura Renata

    2014-01-01

    This project investigates the effects of San Francisco's transition from an industrial to a post-industrial economy on the city's social movements between 1964 and 1979. I re-contextualize the city's Black freedom, feminist, and gay and transgender liberation movements as struggles over the changing nature of urban working-class life and labor in the postwar period. I argue that as San Francisco was increasingly emptied of its white ethnic industrial work force, working-class life became more...

  7. Iron, Oil, and Emeryville: Resource Industrialization and Metropolitan Expansion in the San Francisco Bay Area, 1850-1900

    OpenAIRE

    Lunine, Seth

    2013-01-01

    Scholars have largely overlooked the formative role of industry in both California's economic development and the San Francisco Bay Area's metropolitan expansion during the late nineteenth century. Beginning in the early 1880s, leading firms in San Francisco's specialized industries, such as the iron and chemicals sectors, dispersed to the metropolitan periphery. This process of industrial suburbanization created an integrative metropolitan economy, as well as individual suburbs. In this di...

  8. Interplay between De Novo Biosynthesis and Sequestration of Cyanogenic Glucosides in Arthropods

    DEFF Research Database (Denmark)

    Fürstenberg-Hägg, Joel

    (Zygaenidae, Lepidoptera) both sequester (take up and accumulate) the CNglcs linamarin and lotaustralin from their food plants (Fabacea) and biosynthesize them de novo from valine and isoleucine. The presented research demonstrates that de novo biosynthesis of CNglcs in Z. filipendulae is dependent...

  9. 76 FR 68767 - Draft Guidance for Industry and Food and Drug Administration Staff; De Novo Classification...

    Science.gov (United States)

    2011-11-07

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-D-0689] Draft Guidance for Industry and Food and Drug Administration Staff; De Novo Classification Process... for Industry and Food and Drug Administration Staff; De Novo Classification Process (Evaluation of...

  10. De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

    DEFF Research Database (Denmark)

    Hamilton, P J; Campbell, N G; Sharma, S

    2013-01-01

    De novo genetic variation is an important class of risk factors for autism spectrum disorder (ASD). Recently, whole-exome sequencing of ASD families has identified a novel de novo missense mutation in the human dopamine (DA) transporter (hDAT) gene, which results in a Thr to Met substitution...

  11. Francisco Guerra (1916-2011), medical historian for the world and Puerto Rico.

    Science.gov (United States)

    Rigau-Pérez, José G

    2012-06-01

    This brief celebration of the work of Francisco Guerra (1916-2011) highlights his role as mentor for an international community, his study of local events in the context of global developments, and his contributions to the understanding of the medical history of Puerto Rico. A selective review of Francisco Guerra's methods and publications shows that his principal works are characterized by their vast scope and exhaustive coverage of ancient and modern published sources, coupled with clarity and conciseness of exposition. At least eight of his books (presented here) provide important information on events and personalities in Puerto Rico up to about 1940. Guerra, through his clinical experience, profound scholarship, and personal contacts, recovered the local medical developments of peripheral areas and incorporated them to a global context.

  12. [Historical notes on Infectious Diseases Hospital Francisco Javier Muñiz in Buenos Aires, Argentina].

    Science.gov (United States)

    Laval, Enrique

    2012-08-01

    The Infectious Diseases Hospital Francisco Javier Muñiz, Buenos Aires, Argentina, is the oldest in Latin America. It is over 100 years old and has a history worthy of pride. It became known as "Hospital of the pests" and was preceded by the old House of Insulation, which served as a quarantine station during epidemics of cholera, yellow fever and smallpox. The new House of Insulation, built in the neighborhood of Parque Patricios ("Barracks Hospital"), was renamed in 1904 in memory of Francisco Javier Muñiz, a former military doctor, naturalist and paleontologist. Its technical name is "Porteño Care Centre and National Reference Regional Infectious-Contagious Disease". It receives numerous national and foreign undergraduate and postgraduate students in its Departments of Infectious Diseases and Respiratory Diseases.

  13. Surveillance for previously unmonitored organic contaminants in the San Francisco Estuary.

    Science.gov (United States)

    Oros, Daniel R; Jarman, Walter M; Lowe, Theresa; David, Nicole; Lowe, Sarah; Davis, Jay A

    2003-09-01

    The San Francisco Estuary Regional Monitoring Program initiated surveillance monitoring to identify previously unmonitored synthetic organic contaminants in the San Francisco Estuary. Organic extracts of water samples were analyzed using gas chromatography-mass spectrometry in full scan mode. The major contaminant classes identified in the samples were fire retardants, pesticides, personal care product ingredients, and plasticizers. Evidence from the literature suggests that some of these contaminants can persist in the environment, induce toxicity, and accumulate in marine biota and in higher food chain consumers. The major sources of these contaminants into the marine environment are the discharge of municipal and industrial wastewater effluents, urban stormwater, and agricultural runoff. As a proactive effort, it is suggested that surveillance studies be used routinely in monitoring programs to identify and prevent potential problem contaminants from harming the marine environment.

  14. Earthquakes and faults in the San Francisco Bay area (1970-2003)

    Science.gov (United States)

    Sleeter, Benjamin M.; Calzia, James P.; Walter, Stephen R.; Wong, Florence L.; Saucedo, George J.

    2004-01-01

    The map depicts both active and inactive faults and earthquakes magnitude 1.5 to 7.0 in the greater San Francisco Bay area. Twenty-two earthquakes magnitude 5.0 and greater are indicated on the map and listed chronologically in an accompanying table. The data are compiled from records from 1970-2003. The bathymetry was generated from a digital version of NOAA maps and hydrogeographic data for San Francisco Bay. Elevation data are from the USGS National Elevation Database. Landsat satellite image is from seven Landsat 7 Enhanced Thematic Mapper Plus scenes. Fault data are reproduced with permission from the California Geological Survey. The earthquake data are from the Northern California Earthquake Catalog.

  15. The geotectonic evolution of southern part of Sao Francisco Craton, based in geochronologic interpretation

    International Nuclear Information System (INIS)

    Teixeira, W.

    1985-01-01

    Interpretation of available radiometric data from poly metamorphic terranes of southern part of the Sao Francisco Craton demonstrates the importance of geochronology as a tool in the study of ancient crustal evolution. In addition, radiometric study of basic intrusive magmatism helps define the most important epochs of crustal rifting during the Proterozoic. The definition of the southern border of the cratonic area based on distinctive age patterns of the geochronological provinces is also discussed. Finally, the geochronologic evolution of the Bambui platform cover is presented. Approximately 250 radiometric age determinations (Rb-Sr, K-Ar and Pb-Pb methods) were interpreted principally through the use of iso chronic diagrams. The geologic history tectonomagnetic events identified in this study is compared to the crustal evolution of similar segments of the Sao Francisco Craton and elsewhere. (author)

  16. Migration and HIV Risk Among Men Who Have Sex With Men, San Francisco, 2011.

    Science.gov (United States)

    Lama, T T; Sudhinaraset, M; McFarland, W; Raymond, H F

    2015-12-01

    In San Francisco, MSM account for nearly 90% of HIV infections. Studies have postulated increased risk for HIV faced by MSM who migrate, particularly to urban environments, yet empirical data are lacking. In this study we analyzed data from the National HIV Behavioral Surveillance System collected in 2011 to ascertain whether nativity (U.S. versus foreign born) was associated with HIV prevalence, risk behavior, and service use. Among 510 MSM enrolled, HIV prevalence was 23.0%. Multivariable analyses demonstrate that while nativity was not associated with increased risk for HIV infection, those who had lived in San Francisco for more than five years had higher HIV prevalence compared to those who had lived for less than a year even after adjusting for age, race, income, education, and location of birth.

  17. De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies

    DEFF Research Database (Denmark)

    2014-01-01

    in five individuals and de novo mutations in GABBR2, FASN, and RYR3 in two individuals each. Unlike previous studies, this cohort is sufficiently large to show a significant excess of de novo mutations in epileptic encephalopathy probands compared to the general population using a likelihood analysis (p...... = 8.2 × 10(-4)), supporting a prominent role for de novo mutations in epileptic encephalopathies. We bring statistical evidence that mutations in DNM1 cause epileptic encephalopathy, find suggestive evidence for a role of three additional genes, and show that at least 12% of analyzed individuals have...... analyzed exome-sequencing data of 356 trios with the "classical" epileptic encephalopathies, infantile spasms and Lennox Gastaut syndrome, including 264 trios previously analyzed by the Epi4K/EPGP consortium. In this expanded cohort, we find 429 de novo mutations, including de novo mutations in DNM1...

  18. Genes from scratch--the evolutionary fate of de novo genes.

    Science.gov (United States)

    Schlötterer, Christian

    2015-04-01

    Although considered an extremely unlikely event, many genes emerge from previously noncoding genomic regions. This review covers the entire life cycle of such de novo genes. Two competing hypotheses about the process of de novo gene birth are discussed as well as the high death rate of de novo genes. Despite the high death rate, some de novo genes are retained and remain functional, even in distantly related species, through their integration into gene networks. Further studies combining gene expression with ribosome profiling in multiple populations across different species will be instrumental for an improved understanding of the evolutionary processes operating on de novo genes. Copyright © 2015 The Author. Published by Elsevier Ltd.. All rights reserved.

  19. Modified Mercalli intensities for some recent California earthquakes and historic San Francisco Bay Region earthquakes

    Science.gov (United States)

    Bakun, William H.

    1998-01-01

    Modified Mercalli Intensity (MMI) data for recent California earthquakes were used by Bakun and Wentworth (1997) to develop a strategy for bounding the location and moment magnitude M of earthquakes from MMI observations only. Bakun (Bull. Seismol. Soc. Amer., submitted) used the Bakun and Wentworth (1997) strategy to analyze 19th century and early 20th century San Francisco Bay Region earthquakes. The MMI data and site corrections used in these studies are listed in this Open-file Report. 

  20. Religiosidad e identidad en San Francisco de Campeche. Siglos XVI y XVII

    OpenAIRE

    Rocher Salas, Adriana Delfina

    2006-01-01

    This study examines the problems concomitant to the development of a common identity among the Spanish settlers of San Francisco de Campeche during the Colonial period, with focus on the role played by religious elements in the shaping of this identity – in particular, the cult to the saints. An analysis of factors such as the characteristics of the saints in the neighborhood and local associations; processes of cult adoption, adaptation or dismissal; as well as the participation of the ...

  1. Global Health Diplomacy, "San Francisco Values," and HIV/AIDS: From the Local to the Global.

    Science.gov (United States)

    Kevany, Sebastian

    2015-01-01

    San Francisco has a distinguished history as a cosmopolitan, progressive, and international city, including extensive associations with global health. These circumstances have contributed to new, interdisciplinary scholarship in the field of global health diplomacy (GHD). In the present review, we describe the evolution and history of GHD at the practical and theoretical levels within the San Francisco medical community, trace related associations between the local and the global, and propose a range of potential opportunities for further development of this dynamic field. We provide a historical overview of the development of the "San Francisco Model" of collaborative, community-owned HIV/AIDS treatment and care programs as pioneered under the "Ward 86" paradigm of the 1980s. We traced the expansion and evolution of this model to the national level under the Ryan White Care Act, and internationally via the President's Emergency Plan for AIDS Relief. In parallel, we describe the evolution of global health diplomacy practices, from the local to the global, including the integration of GHD principles into intervention design to ensure social, political, and cultural acceptability and sensitivity. Global health programs, as informed by lessons learned from the San Francisco Model, are increasingly aligned with diplomatic principles and practices. This awareness has aided implementation, allowed policymakers to pursue related and progressive social and humanitarian issues in conjunction with medical responses, and elevated global health to the realm of "high politics." In the 21st century, the integration between diplomatic, medical, and global health practices will continue under "smart global health" and GHD paradigms. These approaches will enhance intervention cost-effectiveness by addressing and optimizing, in tandem with each other, a wide range of (health and non-health) foreign policy, diplomatic, security, and economic priorities in a synergistic manner

  2. Liminalidad social y negociación cultural: inmigrantes yucatecos en San Francisco, California

    Directory of Open Access Journals (Sweden)

    Inés Cornejo-Portugal

    2012-01-01

    Full Text Available Mediante los conceptos de liminalidad social y negociación cultural analizamos tres estudios de caso de yucatecos migrantes en San Francisco, California. Los migrantes estudiados dan cuenta de las diversas formas como utilizan los recursos sociales a los cuales tienen acceso (familiares, de creencia, de amistad y vecinales y que les permiten encontrar un equilibrio emocional relativo, frente a la tensión cultural de la sociedad destino.

  3. After the I-Hotel : Material, Cultural, and Affective Geographies of Filipino San Francisco

    OpenAIRE

    Tagle, Thea Quiray

    2015-01-01

    This dissertation traces the cultural and economic trajectories of Filipino migration to, settlement in, and displacement from the San Francisco Bay Area from the 1960s through the present moment as represented in the work of local poets, visual artists, and performers. After the I-Hotel argues that the shifting representations of urban and suburban space over this time period not only reveal the structural forces behind the displacement of old and new Filipino migrants in the Bay Area, but a...

  4. Groundwater quality in the North San Francisco Bay shallow aquifer, California

    Science.gov (United States)

    Bennett, George L.; Fram, Miranda S.

    2018-02-23

    Groundwater provides more than 40 percent of California’s drinking water. To protect this vital resource, the State of California created the Groundwater Ambient Monitoring and Assessment (GAMA) Program. The Priority Basin Project of the GAMA Program provides a comprehensive assessment of the State’s groundwater quality and increases public access to groundwater-quality information. The North San Francisco Bay Shallow Aquifer constitutes one of the study units being evaluated.

  5. The tectonic evolution of Southern part of the Sao Francisco Craton

    International Nuclear Information System (INIS)

    Teixeira, W.

    1986-01-01

    The potentiality of geochronology when it is applied to the geologic context of craton basement of archean areas is shown. Samples from southern part of the Sao Francisco Craton, in Brazil, were collected for petrographic analysis and geochronological data interpretation. The set of radiometric determinations was obtained by K-Ar, Rb-Sr, Pb-Pb and U-Pb methods. (M.C.K.) [pt

  6. Peptide de novo sequencing of mixture tandem mass spectra

    DEFF Research Database (Denmark)

    Gorshkov, Vladimir; Hotta, Stéphanie Yuki Kolbeck; Braga, Thiago Verano

    2016-01-01

    they decrease the identification performance using database search engines. De novo sequencing approaches are expected to be even more sensitive to the reduction in mass spectrum quality resulting from peptide precursor co-isolation and thus prone to false identifications. The deconvolution approach matched...... complementary b-, y-ions to each precursor peptide mass, which allowed the creation of virtual spectra containing sequence specific fragment ions of each co-isolated peptide. Deconvolution processing resulted in equally efficient identification rates but increased the absolute number of correctly sequenced...... peptides. The improvement was in the range of 20–35% additional peptide identifications for a HeLa lysate sample. Some correct sequences were identified only using unprocessed spectra; however, the number of these was lower than those where improvement was obtained by mass spectral deconvolution. Tight...

  7. Herpes simplex virus 1 induces de novo phospholipid synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Sutter, Esther [Electron Microscopy, Institute of Veterinary Anatomy, University of Zuerich (Switzerland); Oliveira, Anna Paula de; Tobler, Kurt [Electron microscopy, Institute of Virology, University of Zuerich (Switzerland); Schraner, Elisabeth M. [Electron Microscopy, Institute of Veterinary Anatomy, University of Zuerich (Switzerland); Sonda, Sabrina [Institute of Parasitology, University of Zuerich (Switzerland); Kaech, Andres [Center for Microscopy and Image Analysis, University of Zuerich (Switzerland); Lucas, Miriam S. [Electron Microscopy ETH Zuerich (EMEZ), Swiss Federal Institute of Technology, Zuerich (Switzerland); Ackermann, Mathias [Electron microscopy, Institute of Virology, University of Zuerich (Switzerland); Wild, Peter, E-mail: pewild@access.uzh.ch [Electron Microscopy, Institute of Veterinary Anatomy, University of Zuerich (Switzerland)

    2012-08-01

    Herpes simplex virus type 1 capsids bud at nuclear membranes and Golgi membranes acquiring an envelope composed of phospholipids. Hence, we measured incorporation of phospholipid precursors into these membranes, and quantified changes in size of cellular compartments by morphometric analysis. Incorporation of [{sup 3}H]-choline into both nuclear and cytoplasmic membranes was significantly enhanced upon infection. [{sup 3}H]-choline was also part of isolated virions even grown in the presence of brefeldin A. Nuclei expanded early in infection. The Golgi complex and vacuoles increased substantially whereas the endoplasmic reticulum enlarged only temporarily. The data suggest that HSV-1 stimulates phospholipid synthesis, and that de novo synthesized phospholipids are inserted into nuclear and cytoplasmic membranes to i) maintain membrane integrity in the course of nuclear and cellular expansion, ii) to supply membrane constituents for envelopment of capsids by budding at nuclear membranes and Golgi membranes, and iii) to provide membranes for formation of transport vacuoles.

  8. De-novo design of antimicrobial peptides for plant protection.

    Directory of Open Access Journals (Sweden)

    Benjamin Zeitler

    Full Text Available This work describes the de-novo design of peptides that inhibit a broad range of plant pathogens. Four structurally different groups of peptides were developed that differ in size and position of their charged and hydrophobic clusters and were assayed for their ability to inhibit bacterial growth and fungal spore germination. Several peptides are highly active at concentrations between 0,1 and 1 µg/ml against plant pathogenic bacteria, such as Pseudomonas syringae, Pectobacterium carotovorum, and Xanthomonas vesicatoria. Importantly, no hemolytic activity could be detected for these peptides at concentrations up to 200 µg/ml. Moreover, the peptides are also active after spraying on the plant surface demonstrating a possible way of application. In sum, our designed peptides represent new antimicrobial agents and with the increasing demand for antimicrobial compounds for production of "healthy" food, these peptides might serve as templates for novel antibacterial and antifungal agents.

  9. De novo SOX11 mutations cause Coffin-Siris syndrome.

    Science.gov (United States)

    Tsurusaki, Yoshinori; Koshimizu, Eriko; Ohashi, Hirofumi; Phadke, Shubha; Kou, Ikuyo; Shiina, Masaaki; Suzuki, Toshifumi; Okamoto, Nobuhiko; Imamura, Shintaro; Yamashita, Michiaki; Watanabe, Satoshi; Yoshiura, Koh-ichiro; Kodera, Hirofumi; Miyatake, Satoko; Nakashima, Mitsuko; Saitsu, Hirotomo; Ogata, Kazuhiro; Ikegawa, Shiro; Miyake, Noriko; Matsumoto, Naomichi

    2014-06-02

    Coffin-Siris syndrome (CSS) is a congenital disorder characterized by growth deficiency, intellectual disability, microcephaly, characteristic facial features and hypoplastic nails of the fifth fingers and/or toes. We previously identified mutations in five genes encoding subunits of the BAF complex, in 55% of CSS patients. Here we perform whole-exome sequencing in additional CSS patients, identifying de novo SOX11 mutations in two patients with a mild CSS phenotype. sox11a/b knockdown in zebrafish causes brain abnormalities, potentially explaining the brain phenotype of CSS. SOX11 is the downstream transcriptional factor of the PAX6-BAF complex, highlighting the importance of the BAF complex and SOX11 transcriptional network in brain development.

  10. De novo transcriptome assembly of shrimp Palaemon serratus

    Directory of Open Access Journals (Sweden)

    Alejandra Perina

    2017-03-01

    Full Text Available The shrimp Palaemon serratus is a coastal decapod crustacean with a high commercial value. It is harvested for human consumption. In this study, we used Illumina sequencing technology (HiSeq 2000 to sequence, assemble and annotate the transcriptome of P. serratus. RNA was isolated from muscle of adults individuals and, from a pool of larvae. A total number of 4 cDNA libraries were constructed, using the TruSeq RNA Sample Preparation Kit v2. The raw data in this study was deposited in NCBI SRA database with study accession number of SRP090769. The obtained data were subjected to de novo transcriptome assembly using Trinity software, and coding regions were predicted by TransDecoder. We used Blastp and Sma3s to annotate the identified proteins. The transcriptome data could provide some insight into the understanding of genes involved in the larval development and metamorphosis.

  11. De novo assembly of a haplotype-resolved human genome.

    Science.gov (United States)

    Cao, Hongzhi; Wu, Honglong; Luo, Ruibang; Huang, Shujia; Sun, Yuhui; Tong, Xin; Xie, Yinlong; Liu, Binghang; Yang, Hailong; Zheng, Hancheng; Li, Jian; Li, Bo; Wang, Yu; Yang, Fang; Sun, Peng; Liu, Siyang; Gao, Peng; Huang, Haodong; Sun, Jing; Chen, Dan; He, Guangzhu; Huang, Weihua; Huang, Zheng; Li, Yue; Tellier, Laurent C A M; Liu, Xiao; Feng, Qiang; Xu, Xun; Zhang, Xiuqing; Bolund, Lars; Krogh, Anders; Kristiansen, Karsten; Drmanac, Radoje; Drmanac, Snezana; Nielsen, Rasmus; Li, Songgang; Wang, Jian; Yang, Huanming; Li, Yingrui; Wong, Gane Ka-Shu; Wang, Jun

    2015-06-01

    The human genome is diploid, and knowledge of the variants on each chromosome is important for the interpretation of genomic information. Here we report the assembly of a haplotype-resolved diploid genome without using a reference genome. Our pipeline relies on fosmid pooling together with whole-genome shotgun strategies, based solely on next-generation sequencing and hierarchical assembly methods. We applied our sequencing method to the genome of an Asian individual and generated a 5.15-Gb assembled genome with a haplotype N50 of 484 kb. Our analysis identified previously undetected indels and 7.49 Mb of novel coding sequences that could not be aligned to the human reference genome, which include at least six predicted genes. This haplotype-resolved genome represents the most complete de novo human genome assembly to date. Application of our approach to identify individual haplotype differences should aid in translating genotypes to phenotypes for the development of personalized medicine.

  12. Application of Generative Autoencoder in De Novo Molecular Design.

    Science.gov (United States)

    Blaschke, Thomas; Olivecrona, Marcus; Engkvist, Ola; Bajorath, Jürgen; Chen, Hongming

    2018-01-01

    A major challenge in computational chemistry is the generation of novel molecular structures with desirable pharmacological and physiochemical properties. In this work, we investigate the potential use of autoencoder, a deep learning methodology, for de novo molecular design. Various generative autoencoders were used to map molecule structures into a continuous latent space and vice versa and their performance as structure generator was assessed. Our results show that the latent space preserves chemical similarity principle and thus can be used for the generation of analogue structures. Furthermore, the latent space created by autoencoders were searched systematically to generate novel compounds with predicted activity against dopamine receptor type 2 and compounds similar to known active compounds not included in the trainings set were identified. © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  13. De novo development of artistic creativity in Alzheimer's disease.

    Science.gov (United States)

    Chakravarty, Ambar

    2011-10-01

    The case of an 82-year-old female with probable Alzheimer's disease (AD), who developed unusual artistic creativity after development of her disease, is described. The possible pathogenetic mechanism is discussed. The patient showed no inclination toward visual arts during her premorbid years. However, 4 years after development of AD suggestive symptoms she started painting beautiful pictures rather impulsively. Some such paintings have been appreciated even by a qualified art expert. Such de novo development of artistic creativity had been described earlier in subjects with the semantic form of fronto-temporal dementia (FTD), but not in AD. The prevailing concept of lateralized compromise and paradoxical functional facilitation, proposed in connection with FTD subjects, may not be applicable in AD subjects where the affection is more diffuse and more posterior in the brain. Hence, the likely pathogenetic mechanism involved in the case described may remain uncertain. Possibilities are discussed.

  14. Novo teste para diagnóstico das afasias

    Directory of Open Access Journals (Sweden)

    José G. Albernaz

    1953-06-01

    Full Text Available Um novo teste para diagnóstico e contrôle do tratamento das diferentes formas de afasia, especialmente adaptado para a língua portuguêsa, é apresentado e descrito em detalhe. O teste, que será de valor para clínicos e psicólogos interessados no tratamento e reabilitação de pacientes afásicos, se executa em cêrca de 30 minutos, interpreta-se fàcilmente e fornece os elementos necessários para o planejamento da reeducação da linguagem. Além disso, a repetição do teste de tempos em tempos indicará os progressos do paciente e sugerirá modificações do plano de tratamento no momento oportuno.

  15. Paleomagnetic investigation of late Quaternary sediments of south San Francisco Bay, California

    Science.gov (United States)

    Hillhouse, John W.

    1977-01-01

    Paleomagnetic inclinations of the Late Quaternary sediments of South San Francisco Bay were determined from bore hole samples collected near Dumbarton Bridge. The sediments consist of estuarine muds and nonmarine sand deposits, floored by bedrock of the Mesozoic Franciscan Formation. - Beneath Dumbarton Bridge the entire sedimentary fill is normally polarized; therefore, the fill postdates the Brunhes-Matayama polarity reversal (700,000 y. B.P.). Magnetic time lines such as the Mono Lake excursion (24,000 y. B.P.) and the reversed Blake event (110,000 y B.P.) were not found in this bore hole. In addition to Holocene and modern deposits of San Francisco Bay, an older estuarine unit occurs in the stratigraphic section. The older unit was deposited during a period of high sea level, tentatively correlated with the Sangamon interglacial period. Because evidence of the Blake event is not present in the older estuarine unit, the proposed age of this unit could not be confirmed. Although the Holocene estuarine deposits of South San Francisco Bay carry stable remanent magnetization, a reliable record of geomagnetic secular variation could not be recovered because the water-saturated sdiment was deformed by drilling.

  16. Modeling Trace Element Concentrations in the San Francisco Bay Estuary from Remote Measurement of Suspended Solids

    Science.gov (United States)

    Press, J.; Broughton, J.; Kudela, R. M.

    2014-12-01

    Suspended and dissolved trace elements are key determinants of water quality in estuarine and coastal waters. High concentrations of trace element pollutants in the San Francisco Bay estuary necessitate consistent and thorough monitoring to mitigate adverse effects on biological systems and the contamination of water and food resources. Although existing monitoring programs collect annual in situ samples from fixed locations, models proposed by Benoit, Kudela, & Flegal (2010) enable calculation of the water column total concentration (WCT) and the water column dissolved concentration (WCD) of 14 trace elements in the San Francisco Bay from a more frequently sampled metric—suspended solids concentration (SSC). This study tests the application of these models with SSC calculated from remote sensing data, with the aim of validating a tool for continuous synoptic monitoring of trace elements in the San Francisco Bay. Using HICO imagery, semi-analytical and empirical SSC algorithms were tested against a USGS dataset. A single-band method with statistically significant linear fit (p Arsenic, Iron, and Lead in the southern region of the Bay were found to exceed EPA water quality criteria for human health and aquatic life. The results of this study demonstrate the potential of monitoring programs using remote observation of trace element concentrations, and provide the foundation for investigation of pollutant sources and pathways over time.

  17. A new species of Hisonotus (Siluriformes, Loricariidae from rio São Francisco basin, Brazil

    Directory of Open Access Journals (Sweden)

    Fábio Roxo

    2015-04-01

    Full Text Available A new species of Hisonotus is described from the rio São Francisco basin. The new species can be distinguished from congeners by having (1 a unique coloration pattern of caudal fin with one black spot extending from its origin to the ventral lobe and two dark spots at the end of the lobe’s rays; (2 odontodes forming longitudinally aligned rows on head and trunk; (3 a functional V-shaped spinelet; (4 a single rostral plate at the tip of the snout; (5 by lacking contrasting dark geometric spots on the anterodorsal region of the body; (6 a lower caudal-peduncle depth; and (7 lower counts of the lateral median plates and (8 higher premaxillary and dentary teeth. The new species is the second described species of the genus Hisonotus in the rio São Francisco basin. It was found inhabiting the marginal vegetation of the rio São Francisco and three of its tributary, rio das Velhas, rio Paraopeba and rio Formoso.

  18. UCSF partnership to enrich science teaching for sixth graders in San Francisco's schools.

    Science.gov (United States)

    Doyle, H J

    1999-04-01

    Increasing the diversity of students entering the health professions is a challenging goal for medical schools. One approach to this goal is to share the enthusiasm and energy of medical students with younger students, who may pursue medical education in the future. The MedTeach program, established in 1989 and coordinated by the Science & Health Education Partnership of the University of California, San Francisco (UCSF), does so by partnering volunteer medical students from UCSF with sixth-grade classes studying the human body. In 1997-98, around 350 sixth-graders in the San Francisco Schools benefitted from the program. Each team of medical student's visits its class ten to 12 times a year to present engaging, hands-on lessons on body systems and health. The medical students are also role models for the middle-school students. In addition, the diverse student population of San Francisco public schools provides a rich environment for the medical students to improve their communication and teaching skills.

  19. De novo identification of viral pathogens from cell culture hologenomes

    Directory of Open Access Journals (Sweden)

    Patowary Ashok

    2012-01-01

    Full Text Available Abstract Background Fast, specific identification and surveillance of pathogens is the cornerstone of any outbreak response system, especially in the case of emerging infectious diseases and viral epidemics. This process is generally tedious and time-consuming thus making it ineffective in traditional settings. The added complexity in these situations is the non-availability of pure isolates of pathogens as they are present as mixed genomes or hologenomes. Next-generation sequencing approaches offer an attractive solution in this scenario as it provides adequate depth of sequencing at fast and affordable costs, apart from making it possible to decipher complex interactions between genomes at a scale that was not possible before. The widespread application of next-generation sequencing in this field has been limited by the non-availability of an efficient computational pipeline to systematically analyze data to delineate pathogen genomes from mixed population of genomes or hologenomes. Findings We applied next-generation sequencing on a sample containing mixed population of genomes from an epidemic with appropriate processing and enrichment. The data was analyzed using an extensive computational pipeline involving mapping to reference genome sets and de-novo assembly. In depth analysis of the data generated revealed the presence of sequences corresponding to Japanese encephalitis virus. The genome of the virus was also independently de-novo assembled. The presence of the virus was in addition, verified using standard molecular biology techniques. Conclusions Our approach can accurately identify causative pathogens from cell culture hologenome samples containing mixed population of genomes and in principle can be applied to patient hologenome samples without any background information. This methodology could be widely applied to identify and isolate pathogen genomes and understand their genomic variability during outbreaks.

  20. The limits of de novo DNA motif discovery.

    Directory of Open Access Journals (Sweden)

    David Simcha

    Full Text Available A major challenge in molecular biology is reverse-engineering the cis-regulatory logic that plays a major role in the control of gene expression. This program includes searching through DNA sequences to identify "motifs" that serve as the binding sites for transcription factors or, more generally, are predictive of gene expression across cellular conditions. Several approaches have been proposed for de novo motif discovery-searching sequences without prior knowledge of binding sites or nucleotide patterns. However, unbiased validation is not straightforward. We consider two approaches to unbiased validation of discovered motifs: testing the statistical significance of a motif using a DNA "background" sequence model to represent the null hypothesis and measuring performance in predicting membership in gene clusters. We demonstrate that the background models typically used are "too null," resulting in overly optimistic assessments of significance, and argue that performance in predicting TF binding or expression patterns from DNA motifs should be assessed by held-out data, as in predictive learning. Applying this criterion to common motif discovery methods resulted in universally poor performance, although there is a marked improvement when motifs are statistically significant against real background sequences. Moreover, on synthetic data where "ground truth" is known, discriminative performance of all algorithms is far below the theoretical upper bound, with pronounced "over-fitting" in training. A key conclusion from this work is that the failure of de novo discovery approaches to accurately identify motifs is basically due to statistical intractability resulting from the fixed size of co-regulated gene clusters, and thus such failures do not necessarily provide evidence that unfound motifs are not active biologically. Consequently, the use of prior knowledge to enhance motif discovery is not just advantageous but necessary. An implementation of

  1. Cinema utópico: a construção de um novo homem e um novo mundo

    OpenAIRE

    Erika Savernini Lopes

    2011-01-01

    O cinema, desde seus primórdios, prefigurou o espaço cibernético como um novo espaço imaterial construído coletivamente. A concepção desse outro lugar não físico para o qual o homem poderia migrar estabelece para o cinema e para o ciberespaço uma relação direta com as utopias. Na acepção do romance filosófico de Thomas More, a Utopia define-se como um outro espaço não-existente, irrealizável e ideal que diagnostica o atual. O cinema carregaria caracteres fundamentais da Utopia tanto no que se...

  2. Anthropogenic influence on recent bathymetric change in west-central San Francisco Bay

    Science.gov (United States)

    Barnard, Patrick L.; Kvitek, Rikk G.

    2010-01-01

    Two multibeam sonar surveys of west-central San Francisco Bay, California, were conducted in 1997 and 2008. Bathymetric change analysis between the two surveys indicates a loss of 14.1 million cubic meters (-3.1 cm/yr-1) of sediment during this time period, representing an approximately three-fold acceleration of the rate that was observed from prior depth change analysis from 1947 to 1979 for all of Central Bay, using more spatially coarse National Ocean Service (NOS) soundings. The portions of the overlapping survey areas between 1997 and 2008 designated as aggregate mining lease sites lost sediment at five times the rate of the remainder of west-central San Francisco Bay. Despite covering only 28% of the analysis area, volume change within leasing areas accounted for 9.2 million cubic meters of sediment loss, while the rest of the area lost 4.9 million cubic meters of sediment. The uncertainty of this recent analysis is more tightly constrained due to more stringent controls on vertical and horizontal position via tightly coupled, inertially aided differential Global Positioning Systems (GPS) solutions for survey vessel trajectory that virtually eliminate inaccuracies from traditional tide modeling and vessel motion artifacts. Further, quantification of systematic depth measurement error can now be calculated through comparison of static surfaces (e.g., bedrock) between surveys using seafloor habitat maps based on acoustic backscatter measurements and ground-truthing with grab samples and underwater video. Sediment loss in the entire San Francisco Bay Coastal System during the last half-century,as estimated from a series of bathymetric change studies, is 240 million cubic meters, and most of this is believed to be coarse sediment (i.e., sand and gravel) from Central Bay and the San Francisco Bar, which is likely to limit the sand supply to adjacent, open-coast beaches. This hypothesis is supported by a calibrated numerical model in a related study that indicates

  3. Waterbird nest monitoring program in San Francisco Bay (2005-10)

    Science.gov (United States)

    Ackerman, Joshua T.; Herzog, Mark P.

    2012-01-01

    Historically, Forster’s Terns (Sterna forsteri), American Avocets (Recurvirostra americana), and Black-necked Stilts (Himantopus mexicanus) were uncommon residents of San Francisco Bay, California (Grinnell and others, 1918; Grinnell and Wythe, 1927; Sibley, 1952). Presently, however, avocets and stilts are the two most abundant breeding shorebirds in San Francisco Bay (Stenzel and others, 2002; Rintoul and others, 2003). More than 4,000 avocets and 1,000 stilts, roughly 20 percent of their San Francisco Bay wintering populations, breed within the estuary, making San Francisco Bay the largest breeding area for these species on the Pacific Coast (Stenzel and others, 2002; Rintoul and others, 2003). Forster’s Terns were first observed breeding in the San Francisco Bay in 1948 (110 nests); they had increased to over 4000 individuals by the 1980s (Sibley, 1952; Gill, 1977; Harvey and others, 1992; Carter and others, 1990) and were estimated at 2000–3000 for 1998–2002; (Strong and others, 2004).It is hypothesized that the relatively large size of the current waterbird breeding populations is a result of the creation of artificial salt evaporation ponds from the 1930s through the 1950s (Gill, 1977; Goals Project, 1999). Until recently, these salt ponds and associated islands used by waterbirds for nesting have been managed relatively similarly and have supported large breeding waterbird populations. Recently, the South Bay Salt Pond Restoration Project has implemented plans to convert 50–90 percent of the 15,000 acres of salt ponds in the South San Francisco Bay back to tidal marsh habitat. Therefore, there is concern that the Restoration Project, while benefiting other native species, could negatively influence local breeding populations of waterbirds that are reliant on salt pond habitats for both breeding and foraging. A primary goal of the South Bay Salt Pond Restoration Project is to maintain current breeding waterbird populations (South Bay Salt Pond Long

  4. On the Origin of De Novo Genes in Arabidopsis thaliana Populations.

    Science.gov (United States)

    Li, Zi-Wen; Chen, Xi; Wu, Qiong; Hagmann, Jörg; Han, Ting-Shen; Zou, Yu-Pan; Ge, Song; Guo, Ya-Long

    2016-08-03

    De novo genes, which originate from ancestral nongenic sequences, are one of the most important sources of protein-coding genes. This origination process is crucial for the adaptation of organisms. However, how de novo genes arise and become fixed in a population or species remains largely unknown. Here, we identified 782 de novo genes from the model plant Arabidopsis thaliana and divided them into three types based on the availability of translational evidence, transcriptional evidence, and neither transcriptional nor translational evidence for their origin. Importantly, by integrating multiple types of omics data, including data from genomes, epigenomes, transcriptomes, and translatomes, we found that epigenetic modifications (DNA methylation and histone modification) play an important role in the origination process of de novo genes. Intriguingly, using the transcriptomes and methylomes from the same population of 84 accessions, we found that de novo genes that are transcribed in approximately half of the total accessions within the population are highly methylated, with lower levels of transcription than those transcribed at other frequencies within the population. We hypothesized that, during the origin of de novo gene alleles, those neutralized to low expression states via DNA methylation have relatively high probabilities of spreading and becoming fixed in a population. Our results highlight the process underlying the origin of de novo genes at the population level, as well as the importance of DNA methylation in this process. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  5. Glucagon infusion increases rate of purine synthesis de novo in rat liver

    International Nuclear Information System (INIS)

    Itakura, Mitsuo; Maeda, Noriaki; Tsuchiya, Masami; Yamashita, Kamejiro

    1987-01-01

    Based on the parallel increases of glucagon, the second peak of hepatic cAMP, and the rate of purine synthesis de novo in the prereplicative period in regenerating rate liver after a 70% hepatectomy, it was hypothesized that glucagon is responsible for the increased rate of purine synthesis de novo. To test this hypothesis, the effect of glucagon or dibutyryl cAMP infusion on the rate of purine synthesis de novo in rat liver was studied. Glucagon infusion but not insulin or glucose infusion increased the rate of purine synthesis de novo, which was assayed by [ 14 C]glycine or [ 14 C]formate incorporation, by 2.7- to 4.3-fold. Glucagon infusion increased cAMP concentrations by 4.9-fold and 5-phosphoribosyl-1-pyrophosphate concentrations by 1.5-fold in liver but did not change the specific activity of amidophosphoribosyltransferase or purine ribonucleotide concentrations. Dibutyryl cAMP infusion also increased the rate of purine synthesis de novo by 2.2- to 4.0-fold. Because glucagon infusion increased the rate of purine synthesis de novo in the presence of unchanged purine ribonucleotide concentrations, it is concluded that glucagon after infusion or in animals after a 70% hepatectomy is playing an anabolic role to increase the rate of purine synthesis de novo by increasing cAMP and 5-phosphoribosyl-1-pyrophosphate concentrations

  6. Role of de novo biosynthesis in ecosystem scale monoterpene emissions from a boreal Scots pine forest

    Directory of Open Access Journals (Sweden)

    R. Taipale

    2011-08-01

    Full Text Available Monoterpene emissions from Scots pine have traditionally been assumed to originate as evaporation from specialized storage pools. More recently, the significance of de novo emissions, originating directly from monoterpene biosynthesis, has been recognized. To study the role of biosynthesis at the ecosystem scale, we measured monoterpene emissions from a Scots pine dominated forest in southern Finland using the disjunct eddy covariance method combined with proton transfer reaction mass spectrometry. The interpretation of the measurements was based on a correlation analysis and a hybrid emission algorithm describing both de novo and pool emissions. During the measurement period May–August 2007, the monthly medians of daytime emissions were 200, 290, 180, and 200 μg m−2 h−1. The emissions were partly light dependent, probably due to de novo biosynthesis. The emission potential for both de novo and pool emissions exhibited a decreasing summertime trend. The ratio of the de novo emission potential to the total emission potential varied between 30 % and 46 %. Although the monthly changes were not significant, the ratio always differed statistically from zero, suggesting that the role of de novo biosynthesis was observable. Given the uncertainties in this study, we conclude that more accurate estimates of the contribution of de novo emissions are required for improving monoterpene emission algorithms for Scots pine dominated forests.

  7. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

    DEFF Research Database (Denmark)

    Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent

    2017-01-01

    or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high......-coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set...

  8. Eculizumab for drug-induced de novo posttransplantation thrombotic microangiopathy: A case report.

    Science.gov (United States)

    Safa, Kassem; Logan, Merranda S; Batal, Ibrahim; Gabardi, Steven; Rennke, Helmut G; Abdi, Reza

    2015-02-01

    De novo thrombotic microangiopathy (TMA) following renal transplantation is a severe complication associated with high rates of allograft failure. Several immunosuppressive agents are associated with TMA. Conventional approaches to managing this entity, such as withdrawal of the offending agent and/or plasmapheresis, often offer limited help, with high rates of treatment failure and graft loss. We herein report a case of drug induced de novo TMA successfully treated using the C5a inhibitor eculizumab in a renal transplant patient. This report highlights a potentially important role for eculizumab in settings where drug-induced de novo TMA is refractory to conventional therapies.

  9. De novo assembly and phasing of a Korean human genome.

    Science.gov (United States)

    Seo, Jeong-Sun; Rhie, Arang; Kim, Junsoo; Lee, Sangjin; Sohn, Min-Hwan; Kim, Chang-Uk; Hastie, Alex; Cao, Han; Yun, Ji-Young; Kim, Jihye; Kuk, Junho; Park, Gun Hwa; Kim, Juhyeok; Ryu, Hanna; Kim, Jongbum; Roh, Mira; Baek, Jeonghun; Hunkapiller, Michael W; Korlach, Jonas; Shin, Jong-Yeon; Kim, Changhoon

    2016-10-13

    Advances in genome assembly and phasing provide an opportunity to investigate the diploid architecture of the human genome and reveal the full range of structural variation across population groups. Here we report the de novo assembly and haplotype phasing of the Korean individual AK1 (ref. 1) using single-molecule real-time sequencing, next-generation mapping, microfluidics-based linked reads, and bacterial artificial chromosome (BAC) sequencing approaches. Single-molecule sequencing coupled with next-generation mapping generated a highly contiguous assembly, with a contig N50 size of 17.9 Mb and a scaffold N50 size of 44.8 Mb, resolving 8 chromosomal arms into single scaffolds. The de novo assembly, along with local assemblies and spanning long reads, closes 105 and extends into 72 out of 190 euchromatic gaps in the reference genome, adding 1.03 Mb of previously intractable sequence. High concordance between the assembly and paired-end sequences from 62,758 BAC clones provides strong support for the robustness of the assembly. We identify 18,210 structural variants by direct comparison of the assembly with the human reference, identifying thousands of breakpoints that, to our knowledge, have not been reported before. Many of the insertions are reflected in the transcriptome and are shared across the Asian population. We performed haplotype phasing of the assembly with short reads, long reads and linked reads from whole-genome sequencing and with short reads from 31,719 BAC clones, thereby achieving phased blocks with an N50 size of 11.6 Mb. Haplotigs assembled from single-molecule real-time reads assigned to haplotypes on phased blocks covered 89% of genes. The haplotigs accurately characterized the hypervariable major histocompatability complex region as well as demonstrating allele configuration in clinically relevant genes such as CYP2D6. This work presents the most contiguous diploid human genome assembly so far, with extensive investigation of

  10. O Custo Meta no Desenvolvimento de Novos Produtos: um caso em indústria de conserva de pescadoThe Target Cost in New Product Development: a case study in the canned fish industryEl Costo Meta en el Desarrollo de Nuevos Productos: un caso en industria de conserva de pescado

    Directory of Open Access Journals (Sweden)

    CARDOSO, Rodrigo dos Santos

    2006-09-01

    Full Text Available RESUMOO artigo tem como objetivo demonstrar a utilização da metodologia do custo meta em uma indústria de conserva de pescado quando do lançamento de um novo líquido de cobertura, que se caracteriza neste ramo como um novo produto. Assim, realizou-se uma pesquisa exploratória, por meio da análise de um caso, com abordagem predominantemente qualitativa. Procurou-se inicialmente propiciar a conceituação da metodologia do custo meta ou alvo e sua principal ferramenta, a engenharia de valor. Em seguida, demonstra-se a aplicação desta metodologia em um caso de desenvolvimento de novo produto em uma indústria de conserva de pescado. Os resultados da pesquisa evidenciam a viabilidade da utilização da metodologia do custo meta neste seguimento de produto, com vistas ao atendimento das exigências do mercado consumidor.ABSTRACTThe present work has the objective of demonstrating the use of target cost methodology in a canned fish industry in the launching of new liquid topping, which is a new product in the field. An exploratory research was made by a case study with qualitative approach. At first the concept of the target cost methodology was provided, the value engineering. Then the implementation of such methodology was demonstrated in a product development case study in a canned fish industry. The results of the research evidenced the viability of the use of the target cost methodology in the product field, in order to attempt to the market exigencies.RESUMENEl artículo tiene por finalidad demostrar el uso de la metodología del costo meta en una industria de conservas de pescado cuando se realizó el lanzamiento de un nuevo líquido de cobertura, que en este ramo se considera un producto nuevo. Para esto se realizó una investigación exploratoria, por medio del análisis de un caso, con planteamiento predominantemente cualitativo. Inicialmente se buscó propiciar la conceptuación de la metodología del costo meta y su principal

  11. Heavy mineral analysis for assessing the provenance of sandy sediment in the San Francisco Bay Coastal System

    Science.gov (United States)

    Wong, Florence L.; Woodrow, Donald L.; McGann, Mary

    2013-01-01

    Heavy or high-specific gravity minerals make up a small but diagnostic component of sediment that is well suited for determining the provenance and distribution of sediment transported through estuarine and coastal systems worldwide. By this means, we see that surficial sand-sized sediment in the San Francisco Bay Coastal System comes primarily from the Sierra Nevada and associated terranes by way of the Sacramento and San Joaquin Rivers and is transported with little dilution through the San Francisco Bay and out the Golden Gate. Heavy minerals document a slight change from the strictly Sierran-Sacramento mineralogy at the confluence of the two rivers to a composition that includes minor amounts of chert and other Franciscan Complex components west of Carquinez Strait. Between Carquinez Strait and the San Francisco Bar, Sierran sediment is intermingled with Franciscan-modified Sierran sediment. The latter continues out the Gate and turns southward towards beaches of the San Francisco Peninsula. The Sierran sediment also fans out from the San Francisco Bar to merge with a Sierran province on the shelf in the Gulf of the Farallones. Beach-sand sized sediment from the Russian River is transported southward to Point Reyes where it spreads out to define a Franciscan sediment province on the shelf, but does not continue southward to contribute to the sediment in the Golden Gate area.

  12. De novo transcriptome assembly of mangosteen (Garcinia mangostana L. fruit

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    Deden Derajat Matra

    2016-12-01

    Full Text Available Garcinia mangostana L. (Mangosteen, of the family Clusiaceae, is one of the economically important tropical fruits in Indonesia. In the present study, we performed de novo transcriptomic analysis of Garcinia mangostana L. through RNA-Seq technology. We obtained the raw data from 12 libraries through Ion Proton System. Clean reads of 191,735,809 were obtained from 307,634,890 raw reads. The raw data obtained in this study can be accessible in DDBJ database with accession number of DRA005014 with bioproject accession number of PRJDB5091. We obtained 268,851 transcripts as well as 155,850 unigenes, having N50 value of 555 and 433 bp, respectively. Transcript/unigene length ranged from 201 to 5916 bp. The unigenes were annotated with two main databases from NCBI and UniProtKB, respectively having annotated-sequences of 73,287 and 73,107, respectively. These transcriptomic data will be beneficial for studying transcriptome of Garcinia mangostana L.

  13. Massively parallel de novo protein design for targeted therapeutics

    KAUST Repository

    Chevalier, Aaron; Silva, Daniel-Adriano; Rocklin, Gabriel J.; Hicks, Derrick R.; Vergara, Renan; Murapa, Patience; Bernard, Steffen M.; Zhang, Lu; Lam, Kwok-Ho; Yao, Guorui; Bahl, Christopher D.; Miyashita, Shin-Ichiro; Goreshnik, Inna; Fuller, James T.; Koday, Merika T.; Jenkins, Cody M.; Colvin, Tom; Carter, Lauren; Bohn, Alan; Bryan, Cassie M.; Ferná ndez-Velasco, D. Alejandro; Stewart, Lance; Dong, Min; Huang, Xuhui; Jin, Rongsheng; Wilson, Ian A.; Fuller, Deborah H.; Baker, David

    2017-01-01

    De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37-43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing.

  14. Sequencing and De Novo Transcriptome Assembly of Brachypodium sylvaticum (Poaceae

    Directory of Open Access Journals (Sweden)

    Samuel E. Fox

    2013-03-01

    Full Text Available Premise of the study: We report the de novo assembly and characterization of the transcriptomes of Brachypodium sylvaticum (slender false-brome accessions from native populations of Spain and Greece, and an invasive population west of Corvallis, Oregon, USA. Methods and Results: More than 350 million sequence reads from the mRNA libraries prepared from three B. sylvaticum genotypes were assembled into 120,091 (Corvallis, 104,950 (Spain, and 177,682 (Greece transcript contigs. In comparison with the B. distachyon Bd21 reference genome and GenBank protein sequences, we estimate >90% exome coverage for B. sylvaticum. The transcripts were assigned Gene Ontology and InterPro annotations. Brachypodium sylvaticum sequence reads aligned against the Bd21 genome revealed 394,654 single-nucleotide polymorphisms (SNPs and >20,000 simple sequence repeat (SSR DNA sites. Conclusions: To our knowledge, this is the first report of transcriptome sequencing of invasive plant species with a closely related sequenced reference genome. The sequences and identified SNP variant and SSR sites will provide tools for developing novel genetic markers for use in genotyping and characterization of invasive behavior of B. sylvaticum.

  15. LESSONS IN DE NOVO PEPTIDE SEQUENCING BY TANDEM MASS SPECTROMETRY

    Science.gov (United States)

    Medzihradszky, Katalin F.; Chalkley, Robert J.

    2015-01-01

    Mass spectrometry has become the method of choice for the qualitative and quantitative characterization of protein mixtures isolated from all kinds of living organisms. The raw data in these studies are MS/MS spectra, usually of peptides produced by proteolytic digestion of a protein. These spectra are “translated” into peptide sequences, normally with the help of various search engines. Data acquisition and interpretation have both been automated, and most researchers look only at the summary of the identifications without ever viewing the underlying raw data used for assignments. Automated analysis of data is essential due to the volume produced. However, being familiar with the finer intricacies of peptide fragmentation processes, and experiencing the difficulties of manual data interpretation allow a researcher to be able to more critically evaluate key results, particularly because there are many known rules of peptide fragmentation that are not incorporated into search engine scoring. Since the most commonly used MS/MS activation method is collision-induced dissociation (CID), in this article we present a brief review of the history of peptide CID analysis. Next, we provide a detailed tutorial on how to determine peptide sequences from CID data. Although the focus of the tutorial is de novo sequencing, the lessons learned and resources supplied are useful for data interpretation in general. PMID:25667941

  16. De novo transcriptome assembly of a sour cherry cultivar, Schattenmorelle

    Directory of Open Access Journals (Sweden)

    Yeonhwa Jo

    2015-12-01

    Full Text Available Sour cherry (Prunus cerasus in the genus Prunus in the family Rosaceae is one of the most popular stone fruit trees worldwide. Of known sour cherry cultivars, the Schattenmorelle is a famous old sour cherry with a high amount of fruit production. The Schattenmorelle was selected before 1650 and described in the 1800s. This cultivar was named after gardens of the Chateau de Moreille in which the cultivar was initially found. In order to identify new genes and to develop genetic markers for sour cherry, we performed a transcriptome analysis of a sour cherry. We selected the cultivar Schattenmorelle, which is among commercially important cultivars in Europe and North America. We obtained 2.05 GB raw data from the Schattenmorelle (NCBI accession number: SRX1187170. De novo transcriptome assembly using Trinity identified 61,053 transcripts in which N50 was 611 bp. Next, we identified 25,585 protein coding sequences using TransDecoder. The identified proteins were blasted against NCBI's non-redundant database for annotation. Based on blast search, we taxonomically classified the obtained sequences. As a result, we provide the transcriptome of sour cherry cultivar Schattenmorelle using next generation sequencing.

  17. Spaced Seed Data Structures for De Novo Assembly

    Directory of Open Access Journals (Sweden)

    Inanç Birol

    2015-01-01

    Full Text Available De novo assembly of the genome of a species is essential in the absence of a reference genome sequence. Many scalable assembly algorithms use the de Bruijn graph (DBG paradigm to reconstruct genomes, where a table of subsequences of a certain length is derived from the reads, and their overlaps are analyzed to assemble sequences. Despite longer subsequences unlocking longer genomic features for assembly, associated increase in compute resources limits the practicability of DBG over other assembly archetypes already designed for longer reads. Here, we revisit the DBG paradigm to adapt it to the changing sequencing technology landscape and introduce three data structure designs for spaced seeds in the form of paired subsequences. These data structures address memory and run time constraints imposed by longer reads. We observe that when a fixed distance separates seed pairs, it provides increased sequence specificity with increased gap length. Further, we note that Bloom filters would be suitable to implicitly store spaced seeds and be tolerant to sequencing errors. Building on this concept, we describe a data structure for tracking the frequencies of observed spaced seeds. These data structure designs will have applications in genome, transcriptome and metagenome assemblies, and read error correction.

  18. De novo protein structure generation from incomplete chemical shift assignments

    Energy Technology Data Exchange (ETDEWEB)

    Shen Yang [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States); Vernon, Robert; Baker, David [University of Washington, Department of Biochemistry and Howard Hughes Medical Institute (United States); Bax, Ad [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States)], E-mail: bax@nih.gov

    2009-02-15

    NMR chemical shifts provide important local structural information for proteins. Consistent structure generation from NMR chemical shift data has recently become feasible for proteins with sizes of up to 130 residues, and such structures are of a quality comparable to those obtained with the standard NMR protocol. This study investigates the influence of the completeness of chemical shift assignments on structures generated from chemical shifts. The Chemical-Shift-Rosetta (CS-Rosetta) protocol was used for de novo protein structure generation with various degrees of completeness of the chemical shift assignment, simulated by omission of entries in the experimental chemical shift data previously used for the initial demonstration of the CS-Rosetta approach. In addition, a new CS-Rosetta protocol is described that improves robustness of the method for proteins with missing or erroneous NMR chemical shift input data. This strategy, which uses traditional Rosetta for pre-filtering of the fragment selection process, is demonstrated for two paramagnetic proteins and also for two proteins with solid-state NMR chemical shift assignments.

  19. Massively parallel de novo protein design for targeted therapeutics

    KAUST Repository

    Chevalier, Aaron

    2017-09-26

    De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37-43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing.

  20. De novo transcriptome assembly of Sorghum bicolor variety Taejin

    Directory of Open Access Journals (Sweden)

    Yeonhwa Jo

    2016-06-01

    Full Text Available Sorghum (Sorghum bicolor, also known as great millet, is one of the most popular cultivated grass species in the world. Sorghum is frequently consumed as food for humans and animals as well as used for ethanol production. In this study, we conducted de novo transcriptome assembly for sorghum variety Taejin by next-generation sequencing, obtaining 8.748 GB of raw data. The raw data in this study can be available in NCBI SRA database with accession number of SRX1715644. Using the Trinity program, we identified 222,161 transcripts from sorghum variety Taejin. We further predicted coding regions within the assembled transcripts by the TransDecoder program, resulting in a total of 148,531 proteins. We carried out BLASTP against the Swiss-Prot protein sequence database to annotate the functions of the identified proteins. To our knowledge, this is the first transcriptome data for a sorghum variety derived from Korea, and it can be usefully applied to the generation of genetic markers.

  1. Massively parallel de novo protein design for targeted therapeutics

    Science.gov (United States)

    Chevalier, Aaron; Silva, Daniel-Adriano; Rocklin, Gabriel J.; Hicks, Derrick R.; Vergara, Renan; Murapa, Patience; Bernard, Steffen M.; Zhang, Lu; Lam, Kwok-Ho; Yao, Guorui; Bahl, Christopher D.; Miyashita, Shin-Ichiro; Goreshnik, Inna; Fuller, James T.; Koday, Merika T.; Jenkins, Cody M.; Colvin, Tom; Carter, Lauren; Bohn, Alan; Bryan, Cassie M.; Fernández-Velasco, D. Alejandro; Stewart, Lance; Dong, Min; Huang, Xuhui; Jin, Rongsheng; Wilson, Ian A.; Fuller, Deborah H.; Baker, David

    2018-01-01

    De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37–43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing. PMID:28953867

  2. De novo malignancy is associated with renal transplant tourism.

    Science.gov (United States)

    Tsai, Meng-Kun; Yang, Ching-Yao; Lee, Chih-Yuan; Yeh, Chi-Chuan; Hu, Rey-Heng; Lee, Po-Huang

    2011-04-01

    Despite the objections to transplant tourism raised by the transplant community, many patients continue travel to other countries to receive commercial transplants. To evaluate some long-term complications, we reviewed medical records of 215 Taiwanese patients (touring group) who received commercial cadaveric renal transplants in China and compared them with those of 321 transplant recipients receiving domestic cadaveric renal transplants (domestic group) over the same 20-year period. Ten years after transplant, the graft and patient survival rates of the touring group were 55 and 81.5%, respectively, compared with 60 and 89.3%, respectively, of the domestic group. The difference between the two groups was not statistically significant. The 10-year cumulative cancer incidence of the touring group (21.5%) was significantly higher than that of the domestic group (6.8%). Univariate and multivariate stepwise regression analyses (excluding time on immunosuppression, an uncontrollable factor) indicated that transplant tourism was associated with significantly higher cancer incidence. Older age at transplantation was associated with a significantly increased cancer risk; however, the risk of de novo malignancy significantly decreased with longer graft survival. Thus, renal transplant tourism may be associated with a higher risk of post-transplant malignancy, especially in patients of older age at transplantation. © 2011 International Society of Nephrology

  3. Programming peptidomimetic syntheses by translating genetic codes designed de novo.

    Science.gov (United States)

    Forster, Anthony C; Tan, Zhongping; Nalam, Madhavi N L; Lin, Hening; Qu, Hui; Cornish, Virginia W; Blacklow, Stephen C

    2003-05-27

    Although the universal genetic code exhibits only minor variations in nature, Francis Crick proposed in 1955 that "the adaptor hypothesis allows one to construct, in theory, codes of bewildering variety." The existing code has been expanded to enable incorporation of a variety of unnatural amino acids at one or two nonadjacent sites within a protein by using nonsense or frameshift suppressor aminoacyl-tRNAs (aa-tRNAs) as adaptors. However, the suppressor strategy is inherently limited by compatibility with only a small subset of codons, by the ways such codons can be combined, and by variation in the efficiency of incorporation. Here, by preventing competing reactions with aa-tRNA synthetases, aa-tRNAs, and release factors during translation and by using nonsuppressor aa-tRNA substrates, we realize a potentially generalizable approach for template-encoded polymer synthesis that unmasks the substantially broader versatility of the core translation apparatus as a catalyst. We show that several adjacent, arbitrarily chosen sense codons can be completely reassigned to various unnatural amino acids according to de novo genetic codes by translating mRNAs into specific peptide analog polymers (peptidomimetics). Unnatural aa-tRNA substrates do not uniformly function as well as natural substrates, revealing important recognition elements for the translation apparatus. Genetic programming of peptidomimetic synthesis should facilitate mechanistic studies of translation and may ultimately enable the directed evolution of small molecules with desirable catalytic or pharmacological properties.

  4. Dominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome.

    Science.gov (United States)

    Boyden, Lynn M; Kam, Chen Y; Hernández-Martín, Angela; Zhou, Jing; Craiglow, Brittany G; Sidbury, Robert; Mathes, Erin F; Maguiness, Sheilagh M; Crumrine, Debra A; Williams, Mary L; Hu, Ronghua; Lifton, Richard P; Elias, Peter M; Green, Kathleen J; Choate, Keith A

    2016-01-15

    Disorders of keratinization (DOK) show marked genotypic and phenotypic heterogeneity. In most cases, disease is primarily cutaneous, and further clinical evaluation is therefore rarely pursued. We have identified subjects with a novel DOK featuring erythrokeratodermia and initially-asymptomatic, progressive, potentially fatal cardiomyopathy, a finding not previously associated with erythrokeratodermia. We show that de novo missense mutations clustered tightly within a single spectrin repeat of DSP cause this novel cardio-cutaneous disorder, which we term erythrokeratodermia-cardiomyopathy (EKC) syndrome. We demonstrate that DSP mutations in our EKC syndrome subjects affect localization of desmosomal proteins and connexin 43 in the skin, and result in desmosome aggregation, widening of intercellular spaces, and lipid secretory defects. DSP encodes desmoplakin, a primary component of desmosomes, intercellular adhesion junctions most abundant in the epidermis and heart. Though mutations in DSP are known to cause other disorders, our cohort features the unique clinical finding of severe whole-body erythrokeratodermia, with distinct effects on localization of desmosomal proteins and connexin 43. These findings add a severe, previously undescribed syndrome featuring erythrokeratodermia and cardiomyopathy to the spectrum of disease caused by mutation in DSP, and identify a specific region of the protein critical to the pathobiology of EKC syndrome and to DSP function in the heart and skin. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  5. De Novo Design of Bioactive Small Molecules by Artificial Intelligence.

    Science.gov (United States)

    Merk, Daniel; Friedrich, Lukas; Grisoni, Francesca; Schneider, Gisbert

    2018-01-01

    Generative artificial intelligence offers a fresh view on molecular design. We present the first-time prospective application of a deep learning model for designing new druglike compounds with desired activities. For this purpose, we trained a recurrent neural network to capture the constitution of a large set of known bioactive compounds represented as SMILES strings. By transfer learning, this general model was fine-tuned on recognizing retinoid X and peroxisome proliferator-activated receptor agonists. We synthesized five top-ranking compounds designed by the generative model. Four of the compounds revealed nanomolar to low-micromolar receptor modulatory activity in cell-based assays. Apparently, the computational model intrinsically captured relevant chemical and biological knowledge without the need for explicit rules. The results of this study advocate generative artificial intelligence for prospective de novo molecular design, and demonstrate the potential of these methods for future medicinal chemistry. © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  6. De novo Biosynthesis of "Non-Natural" Thaxtomin Phytotoxins.

    Science.gov (United States)

    Winn, Michael; Francis, Daniel; Micklefield, Jason

    2018-03-30

    Thaxtomins are diketopiperazine phytotoxins produced by Streptomyces scabies and other actinobacterial plant pathogens that inhibit cellulose biosynthesis in plants. Due to their potent bioactivity and novel mode of action there has been considerable interest in developing thaxtomins as herbicides for crop protection. To address the need for more stable derivatives, we have developed a new approach for structural diversification of thaxtomins. Genes encoding the thaxtomin NRPS from S. scabies, along with genes encoding a promiscuous tryptophan synthase (TrpS) from Salmonella typhimurium, were assembled in a heterologous host Streptomyces albus. Upon feeding indole derivatives to the engineered S. albus strain, tryptophan intermediates with alternative substituents are biosynthesized and incorporated by the NRPS to deliver a series of thaxtomins with different functionalities in place of the nitro group. The approach described herein, demonstrates how genes from different pathways and different bacterial origins can be combined in a heterologous host to create a de novo biosynthetic pathway to "non-natural" product target compounds. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. De novo DNA methylation during monkey pre-implantation embryogenesis.

    Science.gov (United States)

    Gao, Fei; Niu, Yuyu; Sun, Yi Eve; Lu, Hanlin; Chen, Yongchang; Li, Siguang; Kang, Yu; Luo, Yuping; Si, Chenyang; Yu, Juehua; Li, Chang; Sun, Nianqin; Si, Wei; Wang, Hong; Ji, Weizhi; Tan, Tao

    2017-04-01

    Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes. Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA methylation in pre-implantation rhesus monkey embryos as well as male and female gametes studied using an optimized tagmentation-based whole-genome bisulfite sequencing method. We show that upon fertilization, both paternal and maternal genomes undergo active DNA demethylation, and genome-wide de novo DNA methylation is also initiated in the same period. By the 8-cell stage, remethylation becomes more pronounced than demethylation, resulting in an increase in global DNA methylation. Promoters of genes associated with oxidative phosphorylation are preferentially remethylated at the 8-cell stage, suggesting that this mode of energy metabolism may not be favored. Unlike in rodents, X chromosome inactivation is not observed during monkey pre-implantation development. Our study provides the first comprehensive illustration of the 'wax and wane' phases of DNA methylation dynamics. Most importantly, our DNA methyltransferase loss-of-function analysis indicates that DNA methylation influences early monkey embryogenesis.

  8. A crise financeira global e depois: um novo capitalismo?

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Bresser-Pereira

    2010-03-01

    Full Text Available A crise financeira global de 2008 foi conseqüência do processo de financeirização, a criação maciça de riqueza financeira fictícia iniciada da década de 1980, e da hegemonia de uma ideologia reacionária, o neoliberalismo, baseada em mercados auto-regulados e eficientes. Dessa crise emergirá um novo capitalismo, embora sua natureza seja de difícil previsão. Não será financeirizado, mas serão retomadas as tendências presentes nos trinta anos dourados em direção ao capitalismo global e baseado no conhecimento, além da tendência de expansão da democracia, tornando-a mais social e participativa.The 2008 global financial crisis was a consequence of the processes of financialization, the massive creation of fictitious financial wealth which began in the 1980's, and of the hegemony of a reactionary ideology, neoliberalism, based on the belief of the self-regulating capacity and efficiency of markets. From this crisis a new capitalism will emerge, althought its chacarteristics are hard to foresee. It will not be financial, but the tendencies of the 30 "golden years" toward global and knowledge-based capitalism, and the tendency of expansion of democracy will be among them.

  9. Enzyme-like replication de novo in a microcontroller environment.

    Science.gov (United States)

    Tangen, Uwe

    2010-01-01

    The desire to start evolution from scratch inside a computer memory is as old as computing. Here we demonstrate how viable computer programs can be established de novo in a Precambrian environment without supplying any specific instantiation, just starting with random bit sequences. These programs are not self-replicators, but act much more like catalysts. The microcontrollers used in the end are the result of a long series of simplifications. The objective of this simplification process was to produce universal machines with a human-readable interface, allowing software and/or hardware evolution to be studied. The power of the instruction set can be modified by introducing a secondary structure-folding mechanism, which is a state machine, allowing nontrivial replication to emerge with an instruction width of only a few bits. This state-machine approach not only attenuates the problems of brittleness and encoding functionality (too few bits available for coding, and too many instructions needed); it also enables the study of hardware evolution as such. Furthermore, the instruction set is sufficiently powerful to permit external signals to be processed. This information-theoretic approach forms one vertex of a triangle alongside artificial cell research and experimental research on the creation of life. Hopefully this work helps develop an understanding of how information—in a similar sense to the account of functional information described by Hazen et al.—is created by evolution and how this information interacts with or is embedded in its physico-chemical environment.

  10. When it happens again: impact of future San Francisco Bay area earthquakes

    Science.gov (United States)

    Zoback, M.; Boatwright, J.; Kornfield, L.; Scawthorn, C.; Rojahn, C.

    2005-12-01

    San Francisco Bay area earthquakes, like major floods and hurricanes, have the potential for massive damage to dense urban population centers concentrated in vulnerable zones-along active faults, in coastal regions, and along major river arteries. The recent destruction of Hurricane Katrina does have precedent in the destruction following the 1906 "San Francisco" earthquake and fire in which more than 3000 people were killed and 225,000 were left homeless in San Francisco alone, a city of 400,000 at the time. Analysis of a comprehensive set of damage reports from the magnitude (M) 7.9 1906 earthquake indicates a region of ~ 18,000 km2 was subjected to shaking of Modified Mercalli Intensity of VIII or more - motions capable of damaging even modern, well-built structures; more than 60,000 km2 was subjected to shaking of Intensity VII or greater - the threshold for damage to masonry and poorly designed structures. By comparison, Katrina's hurricane force winds and intense rainfall impacted an area of ~100,000 km2 on the Gulf Coast. Thus, the anticipated effects of a future major Bay Area quake to lives, property, and infrastructure are comparable in scale to Katrina. Secondary hazards (levee failure and flooding in the case of Katrina and fire following the 1906 earthquake) greatly compounded the devastation in both disasters. A recent USGS-led study concluded there is a 62% chance of one or more damaging (M6.7 or greater) earthquakes striking the greater San Francisco Bay area over the next 30 years. The USGS prepared HAZUS loss estimates for the 10 most likely forecast earthquakes which range in size from a M6.7 event on a blind thrust to the largest anticipated event, a M7.9 repeat of the 1906 earthquake. The largest economic loss is expected for a repeat of the 1906 quake. Losses in the Bay region for this event are nearly double those predicted for a M6.9 rupture of the entire Hayward Fault in the East Bay. However, because of high density of population along the

  11. Rapid centriole assembly in Naegleria reveals conserved roles for both de novo and mentored assembly.

    Science.gov (United States)

    Fritz-Laylin, Lillian K; Levy, Yaron Y; Levitan, Edward; Chen, Sean; Cande, W Zacheus; Lai, Elaine Y; Fulton, Chandler

    2016-03-01

    Centrioles are eukaryotic organelles whose number and position are critical for cilia formation and mitosis. Many cell types assemble new centrioles next to existing ones ("templated" or mentored assembly). Under certain conditions, centrioles also form without pre-existing centrioles (de novo). The synchronous differentiation of Naegleria amoebae to flagellates represents a unique opportunity to study centriole assembly, as nearly 100% of the population transitions from having no centrioles to having two within minutes. Here, we find that Naegleria forms its first centriole de novo, immediately followed by mentored assembly of the second. We also find both de novo and mentored assembly distributed among all major eukaryote lineages. We therefore propose that both modes are ancestral and have been conserved because they serve complementary roles, with de novo assembly as the default when no pre-existing centriole is available, and mentored assembly allowing precise regulation of number, timing, and location of centriole assembly. © 2016 Wiley Periodicals, Inc.

  12. De Novo Human Cardiac Myocytes for Medical Research: Promises and Challenges

    Directory of Open Access Journals (Sweden)

    Veronique Hamel

    2017-01-01

    Full Text Available The advent of cellular reprogramming technology has revolutionized biomedical research. De novo human cardiac myocytes can now be obtained from direct reprogramming of somatic cells (such as fibroblasts, from induced pluripotent stem cells (iPSCs, which are reprogrammed from somatic cells, and from human embryonic stem cells (hESCs. Such de novo human cardiac myocytes hold great promise for in vitro disease modeling and drug screening and in vivo cell therapy of heart disease. Here, we review the technique advancements for generating de novo human cardiac myocytes. We also discuss several challenges for the use of such cells in research and regenerative medicine, such as the immature phenotype and heterogeneity of de novo cardiac myocytes obtained with existing protocols. We focus on the recent advancements in addressing such challenges.

  13. Novel de novo BRCA2 mutation in a patient with a family history of breast cancer

    DEFF Research Database (Denmark)

    Hansen, Thomas V O; Bisgaard, Marie Luise; Jønson, Lars

    2008-01-01

    whole blood. The paternity was determined by single nucleotide polymorphism (SNP) microarray analysis. Parental origin of the de novo mutation was determined by establishing mutation-SNP haplotypes by variant specific PCR, while de novo and mosaic status was investigated by sequencing of DNA from......BACKGROUND: BRCA2 germ-line mutations predispose to breast and ovarian cancer. Mutations are widespread and unclassified splice variants are frequently encountered. We describe the parental origin and functional characterization of a novel de novo BRCA2 splice site mutation found in a patient...... and synthesis of a truncated BRCA2 protein. The aberrant splicing was verified by RT-PCR analysis on RNA isolated from whole blood of the affected patient. The mutation was not found in any of the patient's parents or in the mother's carcinoma, showing it is a de novo mutation. Variant specific PCR indicates...

  14. Spontaneous de novo vaginal adenosis resembling Bartholin’s ...

    African Journals Online (AJOL)

    Adebayo Alade Adewole

    Spontaneous de novo vaginal adenosis resembling Bartholin's cyst: A case report ... 6 by 5 cm. The cervix, uterus, adnexa and Pouch of Douglas (POD) were normal. .... of vaginal cancer.2–4 Although, DES exposed daughters have an.

  15. Space use and habitat selection of migrant and resident American Avocets in San Francisco Bay

    Science.gov (United States)

    Demers, Scott A.; Takekawa, John Y.; Ackerman, Joshua T.; Warnock, N.; Athearn, N.D.

    2010-01-01

    San Francisco Bay is a wintering area for shorebirds, including American Avocets (Recurvirostra americana). Recently, a new resident population of avocets has emerged, presumably because of the development of tidal marshes into salt-evaporation ponds. In habitat restoration now underway, as many as 90% of salt ponds will be restored to tidal marsh. However, it is unknown if wintering and resident avocets coexist and if their requirements for space and habitat differ, necessitating different management for their populations to be maintained during restoration. We captured and radio-marked wintering avocets at a salt pond and a tidal flat to determine their population status (migrant or resident) and examine their space use and habitat selection. Of the radio-marked avocets, 79% were migrants and 21% were residents. At the salt pond, residents' fidelity to their location of capture was higher, and residents moved less than did migrants from the same site. Conversely, on the tidal flat, fidelity of residents to their site of capture was lower, and residents' home ranges were larger than those of migrants from the same site. Habitat selection of migrants and residents differed little; however, capture site influenced habitat selection far more than the birds' status as migrants or residents. Our study suggests that individual avocets have high site fidelity while wintering in San Francisco Bay, although the avocet as a species is plastic in its space use and habitat selection. This plasticity may allow wintering migrant and resident avocets to adapt to habitat change in San Francisco Bay. ?? The Cooper Ornithological Society 2010.

  16. Knowledge, Indications and Willingness to Take Pre-Exposure Prophylaxis among Transwomen in San Francisco, 2013.

    Directory of Open Access Journals (Sweden)

    Erin C Wilson

    Full Text Available Safe and effective HIV prevention strategies are needed for transwomen. Transwomen in the US have a 34 times greater odds of being infected with HIV than all adults age 15-49, and in San Francisco, California 42.4% of transwomen are estimated to be infected with HIV. Pre-exposure prophylaxis (PrEP is the first biomedical intervention with promise for reducing HIV acquisition in transwomen. However, little is known about whether transwomen know about PrEP, are taking PrEP and would be good candidates for PrEP based on their risk profile and behaviors. A population-based dataset was analyzed to determine how many transwomen in San Francisco knew about PrEP by the end of 2013 - more than a year after iPrex results demonstrated efficacy of PrEP in preventing HIV. We found that of 233 transwomen, only 13.7% had heard of PrEP. Transwomen who were living with HIV compared to those who were HIV-negative, and those who recently injected drugs compared to non-injection drug users were more likely to have heard of PrEP. Based on CDC guidelines for PrEP among MSM and IDU, 45 (30.2% transwomen of the 149 HIV-negative transwomen in the sample were candidates for PrEP. This estimate based on CDC criteria is arguably low. Given that almost half of transwomen in San Francisco are living with HIV, this findings points to a need for further consideration of PrEP criteria that are specific and tailored to the risks for HIV faced by transwomen that are different from MSM and injection drug users. Research to scale up access and test the effectiveness of PrEP for transwomen is also urgently needed.

  17. The NOVO Network: the original scientific basis for its establishment and our R&D vision

    OpenAIRE

    Winkel, Jørgen; Edwards, Kasper; Dellve, L.; Schiller, B.; Westgaard, Rolf H.

    2017-01-01

    The NOVO network is a Nordic non-governmental professional association whose aims are to foster the scientific progress, knowledge and development of the working environment within Healthcare as an integrated part of production system development. The vision is a “Nordic Model for Sustainable Systems” in the healthcare sector. It was founded in 2006 in Copenhagen and was financially supported by the Nordic Council of Ministers from 2007 to 2015. The motivation to establish the NOVO Network ar...

  18. De novo nonsense mutations in ASXL1 cause Bohring-Opitz syndrome

    DEFF Research Database (Denmark)

    Hoischen, Alexander; van Bon, Bregje W M; Rodríguez-Santiago, Benjamín

    2011-01-01

    Bohring-Opitz syndrome is characterized by severe intellectual disability, distinctive facial features and multiple congenital malformations. We sequenced the exomes of three individuals with Bohring-Opitz syndrome and in each identified heterozygous de novo nonsense mutations in ASXL1, which...... is required for maintenance of both activation and silencing of Hox genes. In total, 7 out of 13 subjects with a Bohring-Opitz phenotype had de novo ASXL1 mutations, suggesting that the syndrome is genetically heterogeneous....

  19. Parnaíba and San Francisco rivers: traveler's fascination and technicians' rationality

    Directory of Open Access Journals (Sweden)

    Gercinair Silvério Gandara

    2013-02-01

    Full Text Available Considering that the environmental variable opens up the prospect of countless historical approaches, I will give attention (having Parnaíba and San Francisco river as scenery to the travelers' accounts,the reports of technicians and engineers, to the political speeches and governmental decisionsundertaken in order to promote better navigability in both rivers. I will also highlight the studies and services aimed to the removal of obstacles the environment from the Parnaíba and San Franciscorivers in the second half the nineteenth century and first half of the twentieth century.

  20. Stable lead isotopic analyses of historic and contemporary lead contamination of San Francisco Bay estuary

    Science.gov (United States)

    Ritson, P.I.; Bouse, R.M.; Flegal, A.R.; Luoma, S.N.

    1999-01-01

    Variations in stable lead isotopic composition (240Pb, 206Pb, 207Pb, 208Pb) in three sediment cores from the San Francisco Bay estuary document temporal changes in sources of lead during the past two centuries. Sediment, with lead from natural geologic sources, and relatively homogeneous lead isotopic compositions are overlain by sediments whose isotopic compositions indicate change in the sources of lead associated with anthropogenic modification of the estuary. The first perturbations of lead isotopic composition in the cores occur in the late 1800s concordant with the beginning of industrialization around the estuary. Large isotopic shifts, toward lower 206Pb/207Pb, occur after the turn of the century in both Richardson and San Pablo Bays. A similar relationship among lead isotopic compositions and lead concentrations in both Bays suggest contamination from the same source (a lead smelter). The uppermost sediments (post 1980) of all cores also have a relatively homogenous lead isotopic composition distinct from pre-anthropogenic and recent aerosol signatures. Lead isotopic compositions of leachates from fourteen surface sediments and five marsh samples from the estuary were also analyzed. These analyses suggest that the lead isotopic signature identified in the upper horizons of the cores is spatially homogeneous among recently deposited sediments throughout the estuary. Current aerosol lead isotopic compositions [Smith, D.R., Niemeyer, S., Flegal, A.R., 1992. Lead sources to California sea otters: industrial inputs circumvent natural lead biodepletion mechanisms. Environmental Research 57, 163-175] are distinct from the isotopic compositions of the surface sediments, suggesting that the major source of lead is cycling of historically contaminated sediments back through the water column. Both the upper core sediments and surface sediments apparently derive their lead predominantly from sources internal to the estuary. These results support the idea that

  1. Francisco Gil y Lemos, gobernador de las islas Malvinas (1774-1777

    Directory of Open Access Journals (Sweden)

    Iago Gil Aguado

    2014-03-01

    Full Text Available La colonia de Puerto Soledad en las islas Malvinas, guarnecida de 1767 a 1811 por tropas españolas, constituía una de las posesiones más remotas y aisladas de la Monarquía Española. Aunque la existencia de la misma ha sido escasamente estudiada, era considerada en la época de gran importancia estratégica para el control de la América meridional y el paso por el Cabo de Hornos. En este artículo se reconstruye la vida y características de la colonia, estudiando el mandato del futuro virrey y ministro de Marina Francisco Gil y Lemos a la cabeza de la misma. Se trata de años clave para su configuración definitiva, en los que, debido a las condiciones climatológicas extremas, se abandonó definitivamente el proyecto de establecer una colonia de población en las islas, reformándose su estructura de gobierno para convertir Puerto Soledad en un presidio destinado exclusivamente a garantizar la soberanía de España sobre el archipiélago. Son asimismo años clave para determinar la soberanía de las islas, ya que hasta 1776 existió una delicada cohabitación con la factoría británica de Port Egmont, que sería definitivamente abandonada por los ingleses durante el gobierno de Francisco Gil y Lemos.The colony of Puerto Soledad in the Falkland Islands, garrisoned by Spain from 1767 to 1811, was one of the most remote and isolated possessions of the Spanish Empire. Despite the fact that it was considered of the utmost strategic importance at the time, it has scarcely received any serious attention. This article studies the characteristics of and daily life in the colony, analysing the governorship of the future Viceroy and First Lord of the Spanish Admiralty Francisco Gil y Lemos. During his years as Governor, plans for the establishment of a permanent civilian settlement in the Falklands were finally dropped due to the extreme climatic conditions on the islands, and Puerto Soledad assumed its definitive role as a purely military outpost

  2. Modeling the Joint Labor-Commute Engagement Decisions of San Francisco Bay Area Residents

    OpenAIRE

    Ory, David T.; Mokhtarian, Patricia L.

    2005-01-01

    Using socio-demographic, personality, and attitudinal data from 1,680 residents of the San Francisco Bay Area, we develop and estimate binary, multinomial, and nested logit models of the choice to work or not, whether or not to work at home, and whether to commute all of the time or some of the time (either by only working part time, or by working a compressed work week, or by telecommuting some of the time). To our knowledge, these are the first models of all these choices simultaneously. Th...

  3. Arquetipos femeninos en las obras de Francisco Umbral y Mario Vargas Llosa

    OpenAIRE

    Godoy Cossío, Ana

    2016-01-01

    Sin duda, investigar a dos escritores como Francisco Umbral y Mario Vargas Llosa ambos situados en el Olimpo de los grandes escritores del siglo XX, no ha sido tarea fácil, pero sí verdaderamente fascinante. Poseedores de talento, creatividad y de genio literario son portadores de una marca propia e indeleble en el periodismo, en el ensayo crítico y en la narrativa. Dos columnas equidistantes y equivalentes con voz propia que se han coronado por igual gracias a sus productivas vidas. En suma,...

  4. Monitoring of water in soil in asparagus irrigated culture in Vale do Sao Francisco, Pernambuco, Brazil

    International Nuclear Information System (INIS)

    Antonino, Antonio C. Dantas; Sampaio, Everardo V.S.B.; Dall' Ollio, Attilio; Bernardo, Ana L. Alves; Audry, Pierre

    1996-08-01

    For many years the brazilian government has inactivated the implantation of irrigated areas in the Sao Francisco valley, obtaining high productivity.After the most appropriated areas having been occupied, the irrigation of second choice soils, usually more shallower and more clay is been tried. In one of these areas, the productivity of asparagus is less than the expected. trying to improve productivity by optimization of irrigation, the movement of water on soil and plants is being monitored far the last year and a half. the main results are shown with emphasis on the raining season, the most problematic

  5. Long path optical extinction and meteorology in the San Francisco bay area

    Energy Technology Data Exchange (ETDEWEB)

    Porch, W M; Galloway, T R; Green, T J; Ellsaesser, H W

    1981-01-01

    Comparison of night-time long path extinction (25 km) across San Francisco Bay and local meteorological measurements at Oakland Airport revealed a dominant role of boundary layer mixing on visibility. Inversion depth and inversion depth multiplied by wind speed were both strongly inversely correlated with night-time atmospheric extinction. Oakland Airport wind speed and humidity showed little correlation with the extinction measurements. Stellar extinction was also found to be sensitive to mixing depth. This is important as visibility and turbidity trend studies rarely include mixing depth measurements. These results indicate the importance of developing instruments to use the same light source for remote sensing of atmospheric constituents, wind and humidity.

  6. Earthquake outlook for the San Francisco Bay region 2014–2043

    Science.gov (United States)

    Aagaard, Brad T.; Blair, James Luke; Boatwright, John; Garcia, Susan H.; Harris, Ruth A.; Michael, Andrew J.; Schwartz, David P.; DiLeo, Jeanne S.; Jacques, Kate; Donlin, Carolyn

    2016-06-13

    Using information from recent earthquakes, improved mapping of active faults, and a new model for estimating earthquake probabilities, the 2014 Working Group on California Earthquake Probabilities updated the 30-year earthquake forecast for California. They concluded that there is a 72 percent probability (or likelihood) of at least one earthquake of magnitude 6.7 or greater striking somewhere in the San Francisco Bay region before 2043. Earthquakes this large are capable of causing widespread damage; therefore, communities in the region should take simple steps to help reduce injuries, damage, and disruption, as well as accelerate recovery from these earthquakes.

  7. A Tidally Averaged Sediment-Transport Model for San Francisco Bay, California

    Science.gov (United States)

    Lionberger, Megan A.; Schoellhamer, David H.

    2009-01-01

    A tidally averaged sediment-transport model of San Francisco Bay was incorporated into a tidally averaged salinity box model previously developed and calibrated using salinity, a conservative tracer (Uncles and Peterson, 1995; Knowles, 1996). The Bay is represented in the model by 50 segments composed of two layers: one representing the channel (>5-meter depth) and the other the shallows (0- to 5-meter depth). Calculations are made using a daily time step and simulations can be made on the decadal time scale. The sediment-transport model includes an erosion-deposition algorithm, a bed-sediment algorithm, and sediment boundary conditions. Erosion and deposition of bed sediments are calculated explicitly, and suspended sediment is transported by implicitly solving the advection-dispersion equation. The bed-sediment model simulates the increase in bed strength with depth, owing to consolidation of fine sediments that make up San Francisco Bay mud. The model is calibrated to either net sedimentation calculated from bathymetric-change data or measured suspended-sediment concentration. Specified boundary conditions are the tributary fluxes of suspended sediment and suspended-sediment concentration in the Pacific Ocean. Results of model calibration and validation show that the model simulates the trends in suspended-sediment concentration associated with tidal fluctuations, residual velocity, and wind stress well, although the spring neap tidal suspended-sediment concentration variability was consistently underestimated. Model validation also showed poor simulation of seasonal sediment pulses from the Sacramento-San Joaquin River Delta at Point San Pablo because the pulses enter the Bay over only a few days and the fate of the pulses is determined by intra-tidal deposition and resuspension that are not included in this tidally averaged model. The model was calibrated to net-basin sedimentation to calculate budgets of sediment and sediment-associated contaminants. While

  8. The core of Francisco Suárez’s doctrine about resistance and tyrannicide

    Directory of Open Access Journals (Sweden)

    Pablo Font Oporto

    2013-12-01

    Full Text Available This article tries to resume the exposition of Francisco Suárez about the problem of the resistance to the tyrant and its interpretation in the scientific doctrine. Suárez distinguishes betweentwo kinds of tyrants: the bad ruler and the usurper. The first only can be murdered in self-defense ofproper life or community; the second can be murdered by any person member of the community, on several conditions. Suárez is criticized because the only limits he establishes to political power are resistance and tyrannicide. However, these mean a democratic control really and physically possible inthe sociopolitical reality of his days.

  9. The thread of the memory in Francisco José Viegas’ fiction

    Directory of Open Access Journals (Sweden)

    Adenize Aparecida Franco

    2018-06-01

    Full Text Available This article presents, based on the analysis of the contemporary Portuguese novel Lourenço Marques (2002, by Francisco José Viegas, some considerations about the constitution of the memory and the identities shaped in the postcolonial context that reached Africa of Portuguese language and the post Carnation Revolution, in Portugal. It is highlighted, firstly, the verification and cataloging of contemporary novels published in Portuguese in the last two decades and that establish relations with the recent historical memory of countries held on totalitarian regimes. Following, there is the analysis of the novel Lourenço Marques as a narrative that configures such elements.

  10. SF-ROCKS: Reaching Out to Communities and Kids With Science in San Francisco

    Science.gov (United States)

    White, L. D.; Grove, K.; La Force, M. J.; Pestrong, R.; Dempsey, D. P.; Garcia, O.; Garfield, N.

    2002-12-01

    The SF-ROCKS program at San Francisco State University (SFSU), funded by a grant from the NSF-OEDG program, aims to increase the number of traditionally underrepresented students who enter college as geoscience majors through a multi-faceted collaborative watershed research project that provides teacher training, student education, and several tiers of mentoring relationships. In partnership with the San Francisco Unified School District and the City College of San Francisco (CCSF), SFSU Geosciences Department faculty guide urban high school students and their teachers in field-based research projects in the Islais, Yosemite, and Mission creek watersheds in southeastern San Francisco. SFSU and CCSF students assist teachers in the classroom and help to mentor their students. The collaborative program has a research base at SFSU and during the next several years will involve five high schools in communities that have highly diverse populations and ongoing environmental problems. Our goal with each high school is to focus earth and environmental science teachers on the geologic setting around their school, and to provide teachers and their students with relevant resources via teacher workshops, frequent interactions with college faculty and students, and an interactive web site and GIS database. During the summer of 2002, project scientists worked with 9th grade Integrated/Environmental Science teachers at Phillip and Sala Burton High School on a multi-layered, hands-on mapping and sampling partnership designed to identify and monitor environmental hazards and watershed characteristics in the Yosemite Creek watershed. The watershed - within which Burton High School is located - provides an interdisciplinary focus for collecting and analyzing rocks, soils, water chemistry and rainfall characteristics. SFSU faculty incorporated concepts and data from the project into ten watershed-theme lesson plans that are now part of the year-long Integrated Science curriculum at the

  11. Selecting Superior De Novo Transcriptome Assemblies: Lessons Learned by Leveraging the Best Plant Genome.

    Directory of Open Access Journals (Sweden)

    Loren A Honaas

    Full Text Available Whereas de novo assemblies of RNA-Seq data are being published for a growing number of species across the tree of life, there are currently no broadly accepted methods for evaluating such assemblies. Here we present a detailed comparison of 99 transcriptome assemblies, generated with 6 de novo assemblers including CLC, Trinity, SOAP, Oases, ABySS and NextGENe. Controlled analyses of de novo assemblies for Arabidopsis thaliana and Oryza sativa transcriptomes provide new insights into the strengths and limitations of transcriptome assembly strategies. We find that the leading assemblers generate reassuringly accurate assemblies for the majority of transcripts. At the same time, we find a propensity for assemblers to fail to fully assemble highly expressed genes. Surprisingly, the instance of true chimeric assemblies is very low for all assemblers. Normalized libraries are reduced in highly abundant transcripts, but they also lack 1000s of low abundance transcripts. We conclude that the quality of de novo transcriptome assemblies is best assessed through consideration of a combination of metrics: 1 proportion of reads mapping to an assembly 2 recovery of conserved, widely expressed genes, 3 N50 length statistics, and 4 the total number of unigenes. We provide benchmark Illumina transcriptome data and introduce SCERNA, a broadly applicable modular protocol for de novo assembly improvement. Finally, our de novo assembly of the Arabidopsis leaf transcriptome revealed ~20 putative Arabidopsis genes lacking in the current annotation.

  12. De novo FBXO11 mutations are associated with intellectual disability and behavioural anomalies.

    Science.gov (United States)

    Fritzen, Daniel; Kuechler, Alma; Grimmel, Mona; Becker, Jessica; Peters, Sophia; Sturm, Marc; Hundertmark, Hela; Schmidt, Axel; Kreiß, Martina; Strom, Tim M; Wieczorek, Dagmar; Haack, Tobias B; Beck-Wödl, Stefanie; Cremer, Kirsten; Engels, Hartmut

    2018-05-01

    Intellectual disability (ID) has an estimated prevalence of 1.5-2%. In most affected individuals, its genetic basis remains unclear. Whole exome sequencing (WES) studies have identified a multitude of novel causative gene defects and have shown that a large proportion of sporadic ID cases results from de novo mutations. Here, we present two unrelated individuals with similar clinical features and deleterious de novo variants in FBXO11 detected by WES. Individual 1, a 14-year-old boy, has mild ID as well as mild microcephaly, corrected cleft lip and alveolus, hyperkinetic disorder, mild brain atrophy and minor facial dysmorphism. WES detected a heterozygous de novo 1 bp insertion in the splice donor site of exon 3. Individual 2, a 3-year-old boy, showed ID and pre- and postnatal growth retardation, postnatal mild microcephaly, hyperkinetic and restless behaviour, as well as mild dysmorphism. WES detected a heterozygous de novo frameshift mutation. While ten individuals with ID and de novo variants in FBXO11 have been reported as part of larger studies, only one of the reports has some additional clinical data. Interestingly, the latter individual carries the identical mutation as our individual 2 and also displays ID, intrauterine growth retardation, microcephaly, behavioural anomalies, and dysmorphisms. Thus, we confirm deleterious de novo mutations in FBXO11 as a cause of ID and start the delineation of the associated clinical picture which may also comprise postnatal microcephaly or borderline small head size and behavioural anomalies.

  13. De novo giant A2 aneurysm following anterior communicating artery occlusion.

    Science.gov (United States)

    Ibrahim, Tarik F; Hafez, Ahmad; Andrade-Barazarte, Hugo; Raj, Rahul; Niemela, Mika; Lehto, Hanna; Numminen, Jussi; Jarvelainen, Juha; Hernesniemi, Juha

    2015-01-01

    De novo intracranial aneurysms are reported to occur with varying incidence after intracranial aneurysm treatment. They are purported to be observed, however, with increased incidence after Hunterian ligation; particularly in cases of carotid artery occlusion for giant or complex aneurysms deemed unclippable. We report a case of right-sided de novo giant A2 aneurysm 6 years after an anterior communicating artery (ACoA) aneurysm clipping. We believe this de novo aneurysm developed in part due to patient-specific risk factors but also a significant change in cerebral hemodynamics. The ACoA became occluded after surgery that likely altered the cerebral hemodynamics and contributed to the de novo aneurysm. We believe this to be the first reported case of a giant de novo aneurysm in this location. Following parent vessel occlusion (mostly of the carotid artery), there are no reports of any de novo aneurysms in the pericallosal arteries let alone a giant one. The patient had a dominant right A1 and the sudden increase in A2 blood flow likely resulted in increased wall shear stress, particularly in the medial wall of the A2 where the aneurysm occurred 2 mm distal to the A1-2 junction. ACoA preservation is a key element of aneurysm surgery in this location. Suspected occlusion of this vessel may warrant closer radiographic follow-up in patients with other risk factors for aneurysm development.

  14. “Metamorfose do espaço habitado” em função de uma nova atividade econômica: a exploração de rochas ornamentais e a valorização do solo no município de Barra de São Francisco - Norte do Espírito Santo

    Directory of Open Access Journals (Sweden)

    Frederico Castro Carvalho

    2013-12-01

    Full Text Available O noroeste do estado do Espírito Santo tem vivenciado um “boom” econômico impulsionado pelas atividades mineradoras relacionadas à exploração de rochas ornamentais, sendo o granito o principal responsável por toda essa dinâmica. As terras da região, em particular as áreas urbanas do município de Barra de São Francisco, têm sido alvo de forte especulação imobiliária devido aos crescentes investimentos do setor de rochas ornamentais. Esse setor tem alterado a dinâmica da cidade francisquense, outrora baseada nas atividades agropecuárias, que tinham no café conilon o pilar de sua economia, assim como a (reconfiguração espacial do município como um todo. A proposta do estudo apresentado consiste em apontar indícios e pistas para se pensar o crescimento das cidades de modo racional no uso e na ocupação dos espaços das áreas urbanas e limítrofes, com o gerenciamento planejado de políticas capazes de promoverem a participação dos atores envolvidos identificando-se os conflitos. Essas políticas devem ser compatíveis com as perspectivas envolvidas, procurando estimular atividades economicamente viáveis e que mantenham um ordenamento na apropriação da paisagem. Abstract “METAMORPHOSIS OF INHABITED SPACE” ACCORDING TO A NEW ECONOMIC ACTIVITY: THE EXPLORATION AND EXPLOITATION OF ROCKS ORMANENTAIS SOIL IN THE MUNICIPALITY OF BARRA DE SÃO FRANCISCO - NORTH OF ESPÍRITO SANTO The northwestern state of Espírito Santo has experienced a ‘boom’ economic driven by mining activities related to the exploitation of ornamental rocks, granite being primarily responsible for this whole dynamic. The lands of the region, in particular the urban areas of the municipality of Barra de São Francisco, has been the subject of strong speculation due to increasing investments in the sector of ornamental rocks. This sector has changed the dynamics of the city francisquense, formerly based on agricultural activities, they had coffee

  15. Contribución a la iconografía del venerable Juan de Palafox. Una nueva obra firmada de Francisco Bayeu

    Directory of Open Access Journals (Sweden)

    Rincón García, Wifredo

    2010-12-01

    Full Text Available A new painting about the venerable Juan de Palafox, signed by Francisco Bayeu, is here presented. It was probably an oil sketch for an altarpiece.

    Se da a conocer una nueva pintura sobre el venerable Juan de Palafox, firmada, de Francisco Bayeu, posible boceto para un cuadro destinado a un retablo.

  16. Handbook of Techniques and Guides for the Study of the San Francisco Bay-Delta-Estuary Complex, Part 2. Key to the Phytoplankton Phyla and Genera.

    Science.gov (United States)

    Helrich, Jane

    Project MER (Marine Ecology Research) is aimed at improving environmental education in the San Francisco Bay Area schools. This document is the second of a series of guides designed to help students and teachers gather data concerning the San Francisco Bay-Delta-Estuary Complex and to organize these data to make a contribution to the literature of…

  17. De novo ORFs in Drosophila are important to organismal fitness and evolved rapidly from previously non-coding sequences.

    Directory of Open Access Journals (Sweden)

    Josephine A Reinhardt

    Full Text Available How non-coding DNA gives rise to new protein-coding genes (de novo genes is not well understood. Recent work has revealed the origins and functions of a few de novo genes, but common principles governing the evolution or biological roles of these genes are unknown. To better define these principles, we performed a parallel analysis of the evolution and function of six putatively protein-coding de novo genes described in Drosophila melanogaster. Reconstruction of the transcriptional history of de novo genes shows that two de novo genes emerged from novel long non-coding RNAs that arose at least 5 MY prior to evolution of an open reading frame. In contrast, four other de novo genes evolved a translated open reading frame and transcription within the same evolutionary interval suggesting that nascent open reading frames (proto-ORFs, while not required, can contribute to the emergence of a new de novo gene. However, none of the genes arose from proto-ORFs that existed long before expression evolved. Sequence and structural evolution of de novo genes was rapid compared to nearby genes and the structural complexity of de novo genes steadily increases over evolutionary time. Despite the fact that these genes are transcribed at a higher level in males than females, and are most strongly expressed in testes, RNAi experiments show that most of these genes are essential in both sexes during metamorphosis. This lethality suggests that protein coding de novo genes in Drosophila quickly become functionally important.

  18. Relação da expressão de fatores de crescimento celular (IGF-1 e (SCF com fatores prognósticos e o alvo da rapamicina em mamíferos (m-TOR em mastocitomas cutâneos caninos

    Directory of Open Access Journals (Sweden)

    Raquel B. Ferioli

    2013-04-01

    Full Text Available O mastocitoma cutâneo (MTC é a neoplasia maligna mais comum na pele dos cães e seu comportamento biológico é muito variável. Dentre os fatores prognósticos estudados nos MTCs, a classificação histopatológica, o índice proliferativo e o padrão de expressão doc-KIT são os que apresentam uma associação mais relevante com o provável prognóstico deste tumor. O objetivo deste trabalho foi avaliar a expressão proteica de fator de crescimento semelhante à insulina tipo 1 (IGF-1, fator de célula tronco (SCF e sua relação com o receptor tirosina quinase (c-KIT, alvo da rapamicina em mamíferos (m-TOR, grau histológico, índice proliferativo pelo KI-67e o número de figuras de mitose (IM com dados clínicos de cães com MTCs . Foram utilizadas 133 amostras de MTCs, provenientes de 133 cães, dispostas em lâminas de microarranjo de tecidos (TMA. A técnica de imuno-histoquímica foi utilizada para a avaliação destas proteínas. Observou-se associação entre SCF e, a graduação histopatológica proposta em 2011, índice mitótico, proliferação celular (KI-67, escore de IGF-1, local da lesão, idade dos animais e padrão imuno-histoquímico do receptor c-KIT. A relação de dependência também foi observada entre IGF-1 e o porte dos animais, IM, m-TOR e c-KIT. A expressão de SCF teve relacção com a agressividade dos MTCs caninos, uma vez que foi mais freqüente em MTCs com c-KIT citoplasmático. A relação entre a expressão de IGF-1, SCF, c-KIT e m-TOR pode estar associada à integralização de suas vias de ação. A expressão de IGF-1 está associada à MTCs em cães de porte grande.

  19. Radioisotope devices at Novo-Krivorozhskij-ore-enrichment plant

    International Nuclear Information System (INIS)

    Levitskij, V.Ya.; Kucher, V.G.; Ministerstvo Chernoj Metallurgii Ukrainskoj SSR, Dnepropetrovsk, Bazovaya Opytno-Konstruktorskaya Izotopnaya lab.)

    1975-01-01

    Use of the ''Ferrite'' analyzers, AZhR and PAZh-1 and the GR-7 gamma relay in different engineering areas of the Novo-Krivorozh ore-enrichment plant is evaluated. The ''Ferrite'' radioisotopic analyzer was designed for rapid roentgeno-radiometric determination of the total iron and iron group element contents in powdered samples of ores and products of their treatment. From the density of the flux of the characteristic radiation it is possible to determine quantitatively the content of the element of interest in the analyzed material. The radioisotpic analyzer AZhR-1 is distinguished by its high efficiency in the analysis for total iron on products of processing of iron ore raw materials. The use of this apparatus allows complete replacement of the chemical method for rapid analysis of concentrates by the roentgeno-radiometric method, which decreases the total analytical work on determination of total iron and speeds up output of information on concentrate quality. The radioisotopic gamma analyzer PAZh-1 is designed for automatic and either continuous or discrete measurement of the total iron content in iron ore materials ground to 50 mm, carried on a conveyor, without selection or preparation of the samples for analysis. The analyzer operates on the principle of measuring the average frequency of impingement on a detector of gamma quanta back-scattered by the analyzed material. This frequency is determined by the percentage content of total iron in the material. The apparatus operates continuously. The mean square deviation of the apparatus values from chemical data is 0.93% Fesub(total). Use of the apparatus greatly increases the operativeness of the control and decreases the laboriousness of raw material sampling in an engineering stream. The radioisotopic data units GR-7 are designed for control of the level of materials in hoppers for recovery and burning of agglomerates. Use of this apparatus showed its great advantage over data units of other types

  20. Internet e Cultura: um novo olhar, veloz e voraz

    Directory of Open Access Journals (Sweden)

    Wilson de Oliveira Souza

    1999-01-01

    Full Text Available Em cada piscadela que damos, um novo mundo enxergamos. Com a globalização, o modo de ver o mundo muda radicalmente, principalmente devido ao complexo ritmo ditado pelas relações entre o meio ambiente e seus usuários. De forma sintetizada, podemos explicar que a globalização é resultado da terceira revolução tecnológica (tecnologias ligadas à busca, processamento, difusão e transmissão de informações; inteligência artificial; engenharia genética, da formação de áreas de livre comércio e blocos econômicos interligados (como o Mercosul, a União Européia e o Nafta e da crescente interligação e interdependência dos mercados físicos e financeiros em escala planetária. Essa trinca é responsável pela alteração, principalmente, da nova forma de enxergarmos a cultura, aceitando que a mundialização da cultura é um processo em curso, não concluído ainda, na qual as formas culturais nacionais ou locais entram em contato rapidamente. Com isso, quedam as barreiras territoriais, forçam as mediações e criam, no dizer de Featherstone, a "terceira cultura", entendendo como "um conjunto de práticas, conhecimentos, convenções e estilos de vida que se desenvolvem de modo a se tornar cada vez mais independente dos Estados-Nação".

  1. Phenolic Amides Are Potent Inhibitors of De Novo Nucleotide Biosynthesis.

    Science.gov (United States)

    Pisithkul, Tippapha; Jacobson, Tyler B; O'Brien, Thomas J; Stevenson, David M; Amador-Noguez, Daniel

    2015-09-01

    An outstanding challenge toward efficient production of biofuels and value-added chemicals from plant biomass is the impact that lignocellulose-derived inhibitors have on microbial fermentations. Elucidating the mechanisms that underlie their toxicity is critical for developing strategies to overcome them. Here, using Escherichia coli as a model system, we investigated the metabolic effects and toxicity mechanisms of feruloyl amide and coumaroyl amide, the predominant phenolic compounds in ammonia-pretreated biomass hydrolysates. Using metabolomics, isotope tracers, and biochemical assays, we showed that these two phenolic amides act as potent and fast-acting inhibitors of purine and pyrimidine biosynthetic pathways. Feruloyl or coumaroyl amide exposure leads to (i) a rapid buildup of 5-phosphoribosyl-1-pyrophosphate (PRPP), a key precursor in nucleotide biosynthesis, (ii) a rapid decrease in the levels of pyrimidine biosynthetic intermediates, and (iii) a long-term generalized decrease in nucleotide and deoxynucleotide levels. Tracer experiments using (13)C-labeled sugars and [(15)N]ammonia demonstrated that carbon and nitrogen fluxes into nucleotides and deoxynucleotides are inhibited by these phenolic amides. We found that these effects are mediated via direct inhibition of glutamine amidotransferases that participate in nucleotide biosynthetic pathways. In particular, feruloyl amide is a competitive inhibitor of glutamine PRPP amidotransferase (PurF), which catalyzes the first committed step in de novo purine biosynthesis. Finally, external nucleoside supplementation prevents phenolic amide-mediated growth inhibition by allowing nucleotide biosynthesis via salvage pathways. The results presented here will help in the development of strategies to overcome toxicity of phenolic compounds and facilitate engineering of more efficient microbial producers of biofuels and chemicals. Copyright © 2015, Pisithkul et al.

  2. Potencial forrageiro de novos clones de capim-elefante

    Directory of Open Access Journals (Sweden)

    Botrel Milton de Andrade

    2000-01-01

    Full Text Available O objetivo deste trabalho foi avaliar o comportamento de novos clones selecionados de capim-elefante. O experimento foi realizado na Embrapa Gado de Leite, em Coronel Pacheco -- MG, por um período de dois anos. Foi avaliado o potencial forrageiro de 20 clones de capim-elefante, obtidos pelo programa de melhoramento, e mais duas cultivares tradicionais (Cameroon e Taiwan A-146 usadas como testemunhas. O delineamento experimental foi o de blocos ao acaso com quatro repetições. As adubações para estabelecimento e manutenção foram realizadas de acordo com a análise do solo, visando suprir as exigências nutricionais do capim-elefante. Observaram-se diferenças significativas entre os clones, quanto ao potencial para produção de forragem, à relação folha/colmo e ao perfilhamento aéreo e basal. A maioria dos clones avaliados apresentou maior produção de matéria seca que as cultivares tradicionais, Cameroon e Taiwan A-146, durante o período seco e chuvoso. Não houve diferença significativa no teor de proteína bruta da matéria seca das cultivares controles (Cameroon e Taiwan A-146 e dos clones avaliados, em ambas as estações (águas e seca. O clone F 27-01, lançado pela Embrapa Gado de Leite com o nome de cultivar Pioneiro, destacou-se para quase todas as características agronômicas estudadas.

  3. Phenolic Amides Are Potent Inhibitors of De Novo Nucleotide Biosynthesis

    Science.gov (United States)

    Pisithkul, Tippapha; Jacobson, Tyler B.; O'Brien, Thomas J.; Stevenson, David M.

    2015-01-01

    An outstanding challenge toward efficient production of biofuels and value-added chemicals from plant biomass is the impact that lignocellulose-derived inhibitors have on microbial fermentations. Elucidating the mechanisms that underlie their toxicity is critical for developing strategies to overcome them. Here, using Escherichia coli as a model system, we investigated the metabolic effects and toxicity mechanisms of feruloyl amide and coumaroyl amide, the predominant phenolic compounds in ammonia-pretreated biomass hydrolysates. Using metabolomics, isotope tracers, and biochemical assays, we showed that these two phenolic amides act as potent and fast-acting inhibitors of purine and pyrimidine biosynthetic pathways. Feruloyl or coumaroyl amide exposure leads to (i) a rapid buildup of 5-phosphoribosyl-1-pyrophosphate (PRPP), a key precursor in nucleotide biosynthesis, (ii) a rapid decrease in the levels of pyrimidine biosynthetic intermediates, and (iii) a long-term generalized decrease in nucleotide and deoxynucleotide levels. Tracer experiments using 13C-labeled sugars and [15N]ammonia demonstrated that carbon and nitrogen fluxes into nucleotides and deoxynucleotides are inhibited by these phenolic amides. We found that these effects are mediated via direct inhibition of glutamine amidotransferases that participate in nucleotide biosynthetic pathways. In particular, feruloyl amide is a competitive inhibitor of glutamine PRPP amidotransferase (PurF), which catalyzes the first committed step in de novo purine biosynthesis. Finally, external nucleoside supplementation prevents phenolic amide-mediated growth inhibition by allowing nucleotide biosynthesis via salvage pathways. The results presented here will help in the development of strategies to overcome toxicity of phenolic compounds and facilitate engineering of more efficient microbial producers of biofuels and chemicals. PMID:26070680

  4. Sediment transport in the San Francisco Bay Coastal System: An overview

    Science.gov (United States)

    Barnard, Patrick L.; Schoellhamer, David H.; Jaffe, Bruce E.; Lester J. McKee,

    2013-01-01

    The papers in this special issue feature state-of-the-art approaches to understanding the physical processes related to sediment transport and geomorphology of complex coastal-estuarine systems. Here we focus on the San Francisco Bay Coastal System, extending from the lower San Joaquin-Sacramento Delta, through the Bay, and along the adjacent outer Pacific Coast. San Francisco Bay is an urbanized estuary that is impacted by numerous anthropogenic activities common to many large estuaries, including a mining legacy, channel dredging, aggregate mining, reservoirs, freshwater diversion, watershed modifications, urban run-off, ship traffic, exotic species introductions, land reclamation, and wetland restoration. The Golden Gate strait is the sole inlet connecting the Bay to the Pacific Ocean, and serves as the conduit for a tidal flow of ~ 8 x 109 m3/day, in addition to the transport of mud, sand, biogenic material, nutrients, and pollutants. Despite this physical, biological and chemical connection, resource management and prior research have often treated the Delta, Bay and adjacent ocean as separate entities, compartmentalized by artificial geographic or political boundaries. The body of work herein presents a comprehensive analysis of system-wide behavior, extending a rich heritage of sediment transport research that dates back to the groundbreaking hydraulic mining-impact research of G.K. Gilbert in the early 20th century.

  5. Reflexiones sobre el viaje de Francisco de Miranda al Imperio Otomano

    Directory of Open Access Journals (Sweden)

    Mehmet Necati Kutlu

    2007-01-01

    Full Text Available Francisco de Miranda, en sus viajes por Europa, permanció casi tres meses en el Imperio Otomano (en Esmirna y Estambul. En sus escritos, el político venezolano se refirió especialmente a la vida social y cultural, a la economía y al ejército y a la defensa de Turquía. Por ello, el conocimiento de primera mano de estos aspectos parece la motivación fundamental de su estancia, sin que sea posible señalar ninguna gestión en busca de apoyo a la causa de la independencia americana.Francisco de Miranda, in his travels across Europe, visited for almost three months the Ottoman Empire (Izmir and Istambul. In his writings, the Venezuelan politician dealt especially with social and cultural life, the economy and the army and defence of the country. This is why the first-hand knowledge of these aspects seems to be the main reason of his stay; instead, it is not possible to find any step in the search of support for the American independence.

  6. Francisco Ferreira Saturnino Braga: negócios e fortuna em Campos dos Goytacazes

    Directory of Open Access Journals (Sweden)

    Walter Luiz Carneiro de Mattos Pereira

    2012-12-01

    Full Text Available O artigo pretende investir no estudo da dinâmica da economia em Campos dos Goytacazes, Rio de Janeiro, nas duas décadas que antecedem a abolição da escravatura no Brasil, a partir dos negócios e da fortuna de Francisco Ferreira Saturnino Braga, proprietário de terras, escravos, usineiro, industrial, concessionário de ferrovias e banqueiro, figura-chave para se perceberem as transformações ocorridas em uma área de produção açucareira voltada para o mercado interno. As singularidades e particularidades obtidas pela observação em escala reduzida podem revelar a possibilidade de perceber uma articulação mais ampla com as estruturas de uma economia de mercado.The article intends to invest in the study of the dynamics of the economy in Campos dos Goytacazes, Rio de Janeiro, in the two decades preceding the abolition of slavery in Brazil, from the business and fortune of Francisco Ferreira Saturnino Braga, owner of land, slaves, mill owner, industrial, railroad dealer and banker, a key figure to understand the changes occurred in an area of the sugar production directs to the domestic market. The singularities and particularities obtained by observation in small scale may reveal the possibility of perceiving a broader articulation with the structures of a market economy.

  7. Suspended sediment and sediment-associated contaminants in San Francisco Bay

    Science.gov (United States)

    Schoellhamer, D.H.; Mumley, T.E.; Leatherbarrow, J.E.

    2007-01-01

    Water-quality managers desire information on the temporal and spatial variability of contaminant concentrations and the magnitudes of watershed and bed-sediment loads in San Francisco Bay. To help provide this information, the Regional Monitoring Program for Trace Substances in the San Francisco Estuary (RMP) takes advantage of the association of many contaminants with sediment particles by continuously measuring suspended-sediment concentration (SSC), which is an accurate, less costly, and more easily measured surrogate for several trace metals and organic contaminants. Continuous time series of SSC are collected at several sites in the Bay. Although semidiurnal and diurnal tidal fluctuations are present, most of the variability of SSC occurs at fortnightly, monthly, and semiannual tidal time scales. A seasonal cycle of sediment inflow, wind-wave resuspension, and winnowing of fine sediment also is observed. SSC and, thus, sediment-associated contaminants tend to be greater in shallower water, at the landward ends of the Bay, and in several localized estuarine turbidity maxima. Although understanding of sediment transport has improved in the first 10 years of the RMP, determining a simple mass budget of sediment or associated contaminants is confounded by uncertainties regarding sediment flux at boundaries, change in bed-sediment storage, and appropriate modeling techniques. Nevertheless, management of sediment-associated contaminants has improved greatly. Better understanding of sediment and sediment-associated contaminants in the Bay is of great interest to evaluate the value of control actions taken and the need for additional controls. ?? 2007 Elsevier Inc. All rights reserved.

  8. La poética iluminada de la locura: Francisco Matos Paoli contra el imperio

    Directory of Open Access Journals (Sweden)

    María Giulianna Zambrano Murillo

    2017-01-01

    Full Text Available Este artículo propone una exégesis del poema carcelario “Canto de la locura” (1962 del puertorriqueño Francisco Matos Paoli (1915-2000 como una defensa de la locura como posibilidad epistémica y poética liberadora frente a la biopolítica carcelaria y colonial. En los años cincuenta, el nacionalismo puertorriqueño, además de ser proscrito mediante la Ley 53, conocida como la Mordaza, fue estigmatizado como una amenaza delirante a la estabilidad del Gobierno en la isla. Con una voz poética hiperlúcida que desborda los límites del lenguaje, Matos Paoli insiste en la pregunta por la libertad de la isla mientras denuncia la violencia colonial estadounidense. This article proposes a reading of the poem “Canto de la locura” (1962, written by Puerto Rican Francisco Matos Paoli (1915-2000, as defending madness as an epistemic possibility as well as an emancipatory poetics in the face of penitentiary and colonial biopolitics. In the 1950s, Puerto Rican nationalism, in addition to being prohibited by Law 53, known as la Mordaza (Gag Law, was stigmatized as a delirious threat to the stability of the island’s government. With a hyperlucid poetic voice that exceeds the limits of language, Matos Paoli insists on the question of freedom for Puerto Rico while denouncing the colonial violence of the United States.

  9. Strontium-90 in human bone: 1981 results for New York City and San Francisco

    International Nuclear Information System (INIS)

    Klusek, C.S.

    1982-01-01

    Results are presented of determinations of Sr-90 content of 102 specimens of vertebrae obtained during 1981 in New York City and San Francisco. The average Sr-90 to Ca ratios for adult vertebrae are 0.95 pCi/g Ca (0.037 Bq/g Ca) in New York and 0.61 pCi/g Ca (0.023 Bq/g Ca) in San Francisco, little changed from the average values of the previous year. Average Sr-90 concentrations in children's bone are now little different from the adult values. A two compartment bone model, which accounts for both short and long term retention of Sr-90 in bone, is used to describe the variations of Sr-90 content of bone and provide correlation with dietary Sr-90 intake. Regression analysis of the 21 years of survey data provides values of the relative retention of dietary Sr-90 and the effective bone turnover rates. The bone model gives satisfactory description of observed Sr-90 levels and allows reliable assessment of the long-term behavior of Sr-90 in man

  10. Strontium-90 in human bone: 1980 results for New York City and San Francisco

    International Nuclear Information System (INIS)

    Klusek, C.S.

    1981-01-01

    Results are presented of determinations of 90 Sr content of 75 specimens of vertebrae obtained during 1980 in New York City and San Francisco. The average 90 Sr to Ca ratios for adult vertebrae are 0.95 pCi/g Ca (0.037 Bq/g Ca) in New York and 0.60 pCi/g Ca (0.022 Bq/g Ca) in San Francisco, little changed from the average values of the previous year. Average 90 Sr concentrations in children's bone are now little different from the adult values. A two compartment bone model, which accounts for both short and long term retention of 90 Sr in bone, is used to describe the variations of 90 Sr content of bone and provide correlation with dietary 90 Sr intake. Regression analysis of the 20 years of survey data provides values of the relative retention of dietary 90 Sr and the effective bone turnover rates. The bone model gives satisfactory description of observed 90 Sr levels and allows reliable assessment of the long-term behavior of 90 Sr in man

  11. Secciones en doble T Invertida en el aeropuerto de San Francisco – (EE. UU.

    Directory of Open Access Journals (Sweden)

    Lin, T. Y.

    1972-05-01

    Full Text Available In the carrying out of this work of enlarging the San Francisco International Airport, a criterion has been maintained which has allowed a series of interesting results to be obtained. The building technique is very unusual, giving it the mark of innovation. This technique has made use of prestressed, prefabricated parts, thus reducing by about 40 % the amount of materials that ordinary building methods would have required, lightening the loads, and keeping as far as possible within the limitations imposed by traffic and the terrain. And all without detriment to a considerable aesthetic effect.En la realización de esta obra para la ampliación del aeropuerto internacional de San Francisco se ha mantenido un criterio que ha permitido obtener una serie de resultados interesantes. Presenta un carácter innovador, ya que la técnica constructiva es muy poco habitual. Dicha técnica ha facilitado emplear elementos prefabricados pretensados, reducir en un 40 % la cantidad de materiales que hubieran sido necesarios de haber utilizado una técnica de construcción normal, aligerar las cargas y ceñirse al máximo a una serie de limitaciones impuestas por el tráfico y la naturaleza del terreno; todo ello sin detrimento de obtener un efecto estético considerable.

  12. Spatial and temporal trends of contaminants in eggs of wading birds from San Francisco Bay, California

    Science.gov (United States)

    Hothem, R.L.; Roster, D.L.; King, K.A.; Keldsen, T.J.; Marois, Katherine C.; Wainwright, S.E.

    1995-01-01

    Between 1989 and 1991, reproduction by black-crowned night-herons (Nycticorax nycticorax) and snowy egrets (Egretta thula) was studied at sites in San Francisco Bay. Eggs were collected from these and other bay sites and from South Wilbur Flood Area, a reference site in California's San Joaquin Valley. Eggs were analyzed for inorganic trace elements, organochlorine pesticides, and polychlorinated biphenyls (PCBs). Results were compared among sites and years and with results of previous studies. There was some evidence of impaired reproduction, but concentrations of contaminants were generally lower than threshold levels for such effects. Egg hatchability was generally good, with predation being the factor that most limited reproductive success. Mean PCB concentrations were generally higher in eggs from the south end of San Francisco Bay than from the north, but the only temporal change, an increase, was observed at Alcatraz Island. There were spatial differences for p,p'-DDE in night-heron eggs in 1990, but the highest mean concentration of DDE was in night-heron eggs from South Wilbur in 1991. Temporal declines in maximum concentrations of DDE in eggs were observed in the bay, but means did not change significantly over time, At Bair Island in the southern end of the bay, mean concentrations of mercury decreased while selenium increased in night-heron eggs over time, but there were no clear bay-wide spatial or temporal trends for either element.

  13. The validity of Francisco Suarez’s Philosophy of Law in the Spanish Silver Age

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    Delia Manzanero

    2018-05-01

    Full Text Available The present article seeks to present the revitalization that occurs during the Spanish Silver Age of the topics and the juridical methodology of the Spanish Natural Law Classics, which has in the Jesuit philosopher and theologian Francisco Suarez, one of the prime leading figures. In order to deal with this stage of revitalization of the iusnaturalist Suarezian theses and their repercussions in the Spanish Natural Law Philosophy that unfolds during the last third of the nineteenth century and the first decades of the twentieth century, we will emphasize the concomitances between the nineteenth-century Krausists and those who lived the magni Hispani, to reach what we consider to be an indispensable link in this phase of recovery of the Natural Law theory: the substantial reading on Francisco Suarez’s legal work made by the iusphilosopher Recasens Siches, where we can appreciate the suggestive inspiration contained in the work of our great Spanish classic and where it develops a renew iusnaturalist conception appropriate for our present time.

  14. La estatua de Francisco Pizarro en Lima. Historia e identidad nacional

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    Varón Gabai, Rafael

    2006-04-01

    Full Text Available Historical account of the statue of Francisco Pizarro in Lima, one of the few that recalls the memory of a conquistador in Latin America. Mention is made of the foundry and exhibition of the different statues of Pizarro as conceived by artist Charles Cary Rumsey, and popular ideas about it. Finally, analysis is offered of the present day perception Peruvians have of the Conquest and what Pizarro’s statue symbolizes to them.

    Recuento histórico de la estatua dedicada a Francisco Pizarro en Lima, una de las pocas que conmemoran a un conquistador español en Hispanoamérica. Se relata la fabricación y exhibición de las diversas estatuas gemelas que realizó el artista Charles Cary Rumsey y las creencias populares al respecto. Asimismo, se analiza la vigencia que mantiene entre la población peruana actual el impacto de la conquista y el símbolo que representa la estatua de Pizarro.

  15. Three-dimensional Modeling of Tidal Hydrodynamics in the San Francisco Estuary

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    Edward S. Gross

    2010-01-01

    Full Text Available Simulations of circulation in the San Francisco Estuary were performed with the three-dimensional TRIM3D hydrodynamic model using a generic length scale turbulence closure. The model was calibrated to reproduce observed tidal elevations, tidal currents, and salinity observations in the San Francisco Estuary using data collected during 1996-1998, a period of high and variable freshwater flow. It was then validated for 1994-1995, with emphasis on spring of 1994, a period of intensive data collection in the northern estuary. The model predicts tidal elevations and tidal currents accurately, and realistically predicts salinity at both the seasonal and tidal time scales. The model represents salt intrusion into the estuary accurately, and therefore accurately represents the salt balance. The model’s accuracy is adequate for its intended purposes of predicting salinity, analyzing gravitational circulation, and driving a particle-tracking model. Two applications were used to demonstrate the utility of the model. We estimated the components of the longitudinal salt flux and examined their dependence on flow conditions, and compared predicted salt intrusion with estimates from two empirical models.

  16. Francisco López de Gómara y la Orden de Alcántara

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    Martínez Martínez, María del Carmen

    2015-06-01

    Full Text Available This article brings to light new aspects concerning the biography of Francisco López de Gómara. His desire to take the religious habit of the Order of Alcántara, and the information this provides, allows us to clear up many aspects of his affiliation, his degree of bachelor, and the studies he followed during his stay in Bologna. Among the witnesses are his master, Pedro de Rúa, old companions from the Spanish College of San Clemente, and neighbours from the town of Gómara.Este artículo da a conocer aspectos inéditos de la biografía de Francisco López de Gómara. Su solicitud de un hábito de religioso de la Orden de Alcántara y la consiguiente información permite aclarar su filiación, su grado de bachiller y los estudios realizados durante su estancia en Bolonia. Entre los testigos están su maestro Pedro de Rúa, antiguos compañeros del Colegio de San Clemente y algunos vecinos de la villa de Gómara.

  17. Final report for sea-level rise response modeling for San Francisco Bay estuary tidal marshes

    Science.gov (United States)

    Takekawa, John Y.; Thorne, Karen M.; Buffington, Kevin J.; Spragens, Kyle A.; Swanson, Kathleen M.; Drexler, Judith Z.; Schoellhamer, David H.; Overton, Cory T.; Casazza, Michael L.

    2013-01-01

    The International Panel on Climate Change has identified coastal ecosystems as areas that will be disproportionally affected by climate change. Current sea-level rise projections range widely with 0.57 to 1.9 meters increase in mea sea level by 2100. The expected accelerated rate of sea-level rise through the 21st century will put many coastal ecosystems at risk, especially those in topographically low-gradient areas. We assessed marsh accretion and plant community state changes through 2100 at 12 tidal salt marshes around San Francisco Bay estuary with a sea-level rise response model. Detailed ground elevation, vegetation, and water level data were collected at all sites between 2008 and 2011 and used as model inputs. Sediment cores (taken by Callaway and others, 2012) at four sites around San Francisco Bay estuary were used to estimate accretion rates. A modification of the Callaway and others (1996) model, the Wetland Accretion Rate Model for Ecosystem Resilience (WARMER), was utilized to run sea-level rise response models for all sites. With a mean sea level rise of 1.24 m by 2100, WARMER projected that the vast majority, 95.8 percent (1,942 hectares), of marsh area in our study will lose marsh plant communities by 2100 and to transition to a relative elevation range consistent with mudflat habitat. Three marshes were projected to maintain marsh vegetation to 2100, but they only composed 4.2 percent (85 hectares) of the total marsh area surveyed.

  18. Microphytobenthos potential productivity estimated in three tidal embayments of the San Francisco Bay system

    Science.gov (United States)

    Guarini, Jean-Marc; Cloern, James E.; Edmunds, Jody L.; Gros, Philippe

    2002-01-01

    In this paper we describe a three-step procedure to infer the spatial heterogeneity in microphytobenthos primary productivity at the scale of tidal estuaries and embayments. The first step involves local measurement of the carbon assimilation rate of benthic microalgae to determine the parameters of the photosynthesis-irradiance (P-E) curves (using non-linear optimization methods). In the next step, a resampling technique is used to rebuild pseudo-sampling distributions of the local productivity estimates; these provide error estimates for determining the significance level of differences between sites. The third step combines the previous results with deterministic models of tidal elevation and solar irradiance to compute mean and variance of the daily areal primary productivity over an entire intertidal mudflat area within each embayment. This scheme was applied on three different intertidal mudflat regions of the San Francisco Bay estuary during autumn 1998. Microphytobenthos productivity exhibits strong (ca. 3-fold) significant differences among the major sub-basins of San Francisco Bay. This spatial heterogeneity is attributed to two main causes: significant differences in the photosynthetic competence (P-E parameters) of the microphytobenthos in the different sub-basins, and spatial differences in the phase shifts between the tidal and solar cycles controlling the exposure of intertidal areas to sunlight. The procedure is general and can be used in other estuaries to assess the magnitude and patterns of spatial variability of microphytobenthos productivity at the level of the ecosystems.

  19. Microphytobenthic potential productivity estimated in three tidal embayments of the San Francisco Bay: A comparative study

    Science.gov (United States)

    Guarini, J.-M.; Cloern, James E.; Edmunds, J.

    2002-01-01

    In this paper we describe a three-step procedure to infer the spatial heterogeneity in microphytobenthos primary productivity at the scale of tidal estuaries and embayments. The first step involves local measurement of the carbon assimilation rate of benthic microalgae to determine the parameters of the photosynthesis-irradiance (P-E) curves (using non-linear optimization methods). In the next step, a resampling technique is used to rebuild pseudo-sampling distributions of the local productivity estimates; these provide error estimates for determining the significance level of differences between sites. The third step combines the previous results with deterministic models of tidal elevation and solar irradiance to compute mean and variance of the daily areal primary productivity over an entire intertidal mudflat area within each embayment. This scheme was applied on three different intertidal mudflat regions of the San Francisco Bay estuary during autumn 1998. Microphytobenthos productivity exhibits strong (ca. 3-fold) significant differences among the major sub-basins of San Francisco Bay. This spatial heterogeneity is attributed to two main causes: significant differences in the photosynthetic competence (P-E parameters) of the microphytobenthos in the different sub-basins, and spatial differences in the phase shifts between the tidal and solar cycles controlling the exposure of intertidal areas to sunlight. The procedure is general and can be used in other estuaries to assess the magnitude and patterns of spatial variability of microphytobenthos productivity at the level of the ecosystems.

  20. In-situ measurements of seismic velocities in the San Francisco Bay region...part II

    Science.gov (United States)

    Gibbs, James F.; Fumal, Thomas E.; Borcherdt, Roger D.

    1976-01-01

    Seismic wave velocities (compressional and shear) are important parameters for determining the seismic response characteristics of various geologic units when subjected to strong earthquake ground shaking. Seismic velocities of various units often show a strong correlation with the amounts of damage following large earthquakes and have been used as a basis for certain types of seismic zonation studies. Currently a program is in progress to measure seismic velocities in the San Francisco Bay region at an estimated 150 sites. At each site seismic travel times are measured in drill holes, normally at 2.5-m intervals to a depth of 30 m. Geologic logs are determined from drill hole cuttings, undisturbed samples, and penetrometer samples. The data provide a detailed comparison of geologic and seismic characteristics and provide parameters for estimating strong earthquake ground motions quantitatively at each of the site. A major emphasis of this program is to obtain a detailed comparison of geologic and seismic data on a regional scale for use in seismic zonation. The broad data base available in the San Francisco Bay region suggests using the area as a pilot area for the development of general techniques applicable to other areas.

  1. Deep Borehole Instrumentation Along San Francisco Bay Bridges: 1996 - 2003 and Strong Ground Motion Systhesis Along the San Francisco/Oakland Bay Bridge

    Energy Technology Data Exchange (ETDEWEB)

    Hutchings, L; Foxall, W; Kasameyer, P; larsen, S; Hayek, C; Tyler-Turpin, C; Aquilino, J; Long, L

    2005-04-22

    As a result of collaboration between the Berkeley Seismographic Station, Lawrence Livermore National Laboratory, and Caltrans, instrument packages have been placed in bedrock in six boreholes and two surface sites along the San Francisco/Oakland Bay Bridge. Since 1996 over 200 local earthquakes have been recorded. Prior to this study few seismic recording instruments existed in bed-rock in San Francisco Bay. We utilized the data to perform analysis of ground motion variability, wave passage, site response, and up-and down-hole wave propagation along the Bay Bridge. We also synthesized strong ground motion at nine locations along the Bay Bridge. Key to these studies is LLNL's effort to exploit the information available in weak ground motions (generally from earthquakes < M=4.0) to enhance predictions of seismic hazards. We found that Yerba Island has no apparent site response at the surface relative to a borehole site. The horizontal to vertical spectral ratio method best revealed no site response, while the complex signal spectral ratio method had the lowest variance for spectral ratios and best predicted surface recordings when the borehole recording was used as input. Both methods identified resonances at about the same frequencies. Regional attenuation results in a significant loss of high frequencies in both surface and borehole recordings. Records are band limited at near 3 Hz. Therefore a traditional rock outcrop site response, flat to high frequency in displacement, is not available. We applied a methodology to predict and synthesize strong ground motion along the San Francisco/Oakland Bay Bridge from a M=7.25 earthquake along the Hayward fault, about12 km distant. We synthesized for three-components and broad-band (0.0-25.0 Hz) ground motion accelerations, velocities, and displacements. We examined two different possible rupture scenarios, a ''mean'' and ''one standard deviation'' model. We combined the high

  2. ''de novo'' aneurysms following endovascular procedures

    Energy Technology Data Exchange (ETDEWEB)

    Briganti, F.; Cirillo, S.; Caranci, F. [Department of Neurological Sciences, Services of Neuroradiology, ' ' Federico II' ' University, Naples (Italy); Esposito, F.; Maiuri, F. [Department of Neurological Sciences, Services of Neurosurgery, ' ' Federico II' ' University, Naples (Italy)

    2002-07-01

    Two personal cases of ''de novo'' aneurysms of the anterior communicating artery (ACoA) occurring 9 and 4 years, respectively, after endovascular carotid occlusion are described. A review of the 30 reported cases (including our own two) of ''de novo'' aneurysms after occlusion of the major cerebral vessels has shown some features, including a rather long time interval after the endovascular procedure of up to 20-25 years (average 9.6 years), a preferential ACoA (36.3%) and internal carotid artery-posterior communicating artery (ICA-PCoA) (33.3%) location of the ''de novo'' aneurysms, and a 10% rate of multiple aneurysms. These data are compared with those of the group of reported spontaneous ''de novo'' aneurysms after SAH or previous aneurysm clipping. We agree that the frequency of ''de novo'' aneurysms after major-vessel occlusion (two among ten procedures in our series, or 20%) is higher than commonly reported (0 to 11%). For this reason, we suggest that patients who have been submitted to endovascular major-vessel occlusion be followed up for up to 20-25 years after the procedure, using non-invasive imaging studies such as MR angiography and high-resolution CT angiography. On the other hand, periodic digital angiography has a questionable risk-benefit ratio; it may be used when a ''de novo'' aneurysm is detected or suspected on non-invasive studies. The progressive enlargement of the ACoA after carotid occlusion, as described in our case 1, must be considered a radiological finding of risk for ''de novo'' aneurysm formation. (orig.)

  3. Coccidioidomicose: novo caso brasileiro Coccidiodomycosis: a new Brazilian case

    Directory of Open Access Journals (Sweden)

    Mário A.P. Moraes

    1998-12-01

    Full Text Available É descrito um caso de coccidioidomicose pulmonar oriundo da zona rural de Bertolínia, PI. A manifestação clínica principal consistiu em dor torácica e o diagnóstico teve por base o achado do agente3/4Coccidioides immitis3/4em cortes histológicos. Formas teciduais do microrganismo3/4esférulas imaturas e maduras3/4estavam presentes nas lesões observadas em fragmento pulmonar removido do paciente por biópsia a céu aberto. Este novo caso autóctone da doença, como os outros anteriormente descritos no Brasil, procedia do interior semi-árido da Região Nordeste. O ambiente quente e seco do sertão nordestino oferece, sem dúvida, condições propícias ao desenvolvimento de C. immitis, um habitante do solo. As pessoas e animais do local devem adquirir a infecção ao revolver a terra, ato que os expõe à poeira contendo os propágulos do fungo.A case of pulmonary coccidioidomycosis from the rural zone of Bertolinia, PI, is reported. The patient, a farm worker, attributed his illness to the dust inhaled while digging a water well during the dry season of the year, some weeks before the onset of the clinical manifestations. The main symptoms of the disease were severe chest pain and moderate fever. The diagnosis was made histopathologically: tissue phase fungal organisms3/4immature spherules and spherules with endospores3/4were observed in histological sections of a lung fragment obtained by open chest biopsy. This is the twelfth autochthonous case of coccidioidomycosis found so far in Brazil. All of them involved native inhabitants of the semi-arid part of Northeastern Brazil. The hot and dry environment of the region seems to favor the development of C. immitis in the soil. Humans and animals probably acquire the infection by digging the soil, when they become exposed to the conidium-bearing dust raised by this activity.

  4. 76 FR 54529 - Notice To Rescind a Notice of Intent To Prepare an Environmental Impact Statement: San Francisco...

    Science.gov (United States)

    2011-09-01

    ..., Acting Director, Local Programs, Federal Highway Administration, Sacramento, CA. [FR Doc. 2011-22349... To Prepare an Environmental Impact Statement: San Francisco County, CA AGENCY: Federal Highway..., Oakland, California 94623-0660, Telephone: (510) 286-5231, E-mail: [email protected]ca.gov...

  5. Christopher Columbus, Hernando Cortes, and Francisco Pizzaro: A Qualitative Content Analysis Examining Cultural Bias in World History Textbooks

    Science.gov (United States)

    Lillejord, Jebadiah Serril

    2013-01-01

    The purpose of this study is to investigate to what extent contemporary high school world history textbooks portray Christopher Columbus, Hernán Cortés, and Francisco Pizarro within the context of being "sacred," "profane," or someplace in between. To evaluate for existence of content bias this study employed qualitative…

  6. Risk Behaviors among Asian Women Who Work at Massage Parlors in San Francisco: Perspectives from Masseuses and Owners/Managers

    Science.gov (United States)

    Nemoto, Tooru; Iwamoto, Mariko; Oh, Hyun Joo; Wong, Serena; Nguyen, Hongmai

    2005-01-01

    This study investigates cognitive, cultural, and contextual factors that influence HIV-related risk behaviors among Asian women who engage in sex work at massage parlors in San Francisco. Focus groups and qualitative interviews were conducted for Vietnamese and Thai masseuses and massage parlor owners/managers. Economic pressure as well as…

  7. Sea change under climate change: case studies in rare plant conservation from the dynamic San Francisco Estuary

    Science.gov (United States)

    We present case studies supporting management of two rare plant species in tidal wetlands of the San Francisco Estuary. For an annual hemiparasite, we used demographic analyses to identify factors to enhance population establishment, survivorship and fitness, and to compare reintroduced with natura...

  8. Comparative analysis of long-term chlorophyll data with generalized additive model - San Francisco Bay and St. Lucie Estuary

    Science.gov (United States)

    The health of estuarine ecosystems is often influenced by hydraulic and nutrient loading from upstream watersheds. We examined four decades of monitoring data of nutrient export into the Indian River Lagoon and San Francisco Bay, both of which have received considerable attentio...

  9. Identifying Telemedicine Services to Improve Access to Specialty Care for the Underserved in the San Francisco Safety Net

    Directory of Open Access Journals (Sweden)

    Ken Russell Coelho

    2011-01-01

    Full Text Available Safety-net settings across the country have grappled with providing adequate access to specialty care services. San Francisco General Hospital and Trauma Center, serving as the city's primary safety-net hospital, has also had to struggle with the same issue. With Healthy San Francisco, the City and County of San Francisco's Universal Healthcare mandate, the increased demand for specialty care services has placed a further strain on the system. With the recent passage of California Proposition 1D, infrastructural funds are now set aside to assist in connecting major hospitals with primary care clinics in remote areas all over the state of California, using telemedicine. Based on a selected sample of key informant interviews with local staff physicians, this study provides further insight into the current process of e-referral which uses electronic communication for making referrals to specialty care. It also identifies key services for telemedicine in primary and specialty care settings within the San Francisco public health system. This study concludes with proposals for a framework that seek to increase collaboration between the referring primary care physician and specialist, to prioritize institution of these key services for telemedicine.

  10. Providing Specialty Care for the Poor and Underserved at Student-Run Free Clinics in the San Francisco Bay Area.

    Science.gov (United States)

    Liu, Max Bolun; Xiong, Grace; Boggiano, Victoria Lynn; Ye, Patrick Peiyong; Lin, Steven

    2017-01-01

    This report describes the model of specialty clinics implemented at Stanford University's two student-run free clinics, Arbor Free Clinic and Pacific Free Clinic, in the San Francisco Bay Area. We describe our patient demographic characteristics and the specialty services provided. We discuss challenges in implementing specialty care at student-run free clinics.

  11. Novel Analyses of Long-Term Data Provide a Scientific Basis for Chlorophyll-a Thresholds in San Francisco Bay

    Science.gov (United States)

    San Francisco Bay (SFB), USA, is highly enriched in nitrogen and phosphorus, but has been resistant to the classic symptoms of eutrophication associated with over-production of phytoplankton. Observations in recent years suggest that this resistance may be weakening, shown by: si...

  12. Density and elevational distribution of the San Francisco Peaks ragwort, Packera franciscana (Asteraceae), a threatened single-mountain endemic

    Science.gov (United States)

    James F. Fowler; Carolyn Hull Sieg

    2011-01-01

    Packera franciscana (Greene) W. A. Weber and A. Love is endemic to treeline and alpine habitats of the San Francisco Peaks, Arizona, USA and was listed as a threatened species under the Endangered Species Act in 1983. Species abundance data are limited in scope, yet are critical for recovery of the species, especially in light of predictions of its future extinction...

  13. La teoría de la causalidad natural de Francisco Sánchez el escéptico

    Directory of Open Access Journals (Sweden)

    Rafael V. Orden Jiménez

    2003-01-01

    Full Text Available The most popular work of Francisco Sánchez, Quo nihil scitur (1581, transmits an absolutely sceptic thought. However, other writings like Carmen de Cometa anni M.D.LXXVII (1578, offer us different ideas about how Sánchez considers possible the scientific knowledge like, for example, his idea about the casual relations between natural objects.

  14. Affective foodscapes in an economy of passion : repetition, opposition and adaptation in Mexican restaurants in Amsterdam, Madrid and San Francisco

    NARCIS (Netherlands)

    Matus Ruiz, M.

    2012-01-01

    The
 main
 goal
 of
 my
 research
 was
 to
 analyze
 how
 the
 desire
 to
 affect
 and
 be
 affected
 by
 foreign
 signs
relates
 to
 the
 commoditization
 of
 food
 products
 offered
 in
 Mexican
 restaurants
 in
 Amsterdam,
 Madrid
and
 San
 Francisco.
 I
 conceive
 restaurants
 as


  15. Un documento inedito: Historia de Sebastián de Belalcázar, escrita por su hijo, Don Francisco

    Directory of Open Access Journals (Sweden)

    Juán Friede

    1964-04-01

    Full Text Available El documento que publicamos, inédito hasta ahora es una breve historia de Sebastián de Belalcázar, gobernador de Popayán, muerto en 1550, escrita por su hijo dos Francisco hacia 1557, cuando se encontraba en España.

  16. Infermeria Medicoquirúrgica II. Temari corresponent al Professor Francisco Pérez Dolz. Curs 2017-2018

    OpenAIRE

    Pérez Dolz, Francisco

    2017-01-01

    El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. Temari corresponent al professor Francisco Pérez Dolz

  17. Infermeria Médico-Quirúrgica II. Temari corresponent al Professor Francisco Pérez Dolz. Curs 2017-2018

    OpenAIRE

    Pérez Dolz, Francisco

    2017-01-01

    El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València Infermeria Médico-Quirúrgica II. Temari corresponent al Professor Francisco Pérez Dolz. Curs 2017-2018.

  18. High frequencies of de novo CNVs in bipolar disorder and schizophrenia.

    LENUS (Irish Health Repository)

    Malhotra, Dheeraj

    2011-12-22

    While it is known that rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear. Here, we reasoned that a contribution of CNVs to mood disorders might be most evident for de novo mutations. We performed a genome-wide analysis of de novo CNVs in a cohort of 788 trios. Diagnoses of offspring included bipolar disorder (n = 185), schizophrenia (n = 177), and healthy controls (n = 426). Frequencies of de novo CNVs were significantly higher in bipolar disorder as compared with controls (OR = 4.8 [1.4,16.0], p = 0.009). De novo CNVs were particularly enriched among cases with an age at onset younger than 18 (OR = 6.3 [1.7,22.6], p = 0.006). We also confirmed a significant enrichment of de novo CNVs in schizophrenia (OR = 5.0 [1.5,16.8], p = 0.007). Our results suggest that rare spontaneous mutations are an important contributor to risk for bipolar disorder and other major neuropsychiatric diseases.

  19. De Novo Discovery of Structured ncRNA Motifs in Genomic Sequences

    DEFF Research Database (Denmark)

    Ruzzo, Walter L; Gorodkin, Jan

    2014-01-01

    De novo discovery of "motifs" capturing the commonalities among related noncoding ncRNA structured RNAs is among the most difficult problems in computational biology. This chapter outlines the challenges presented by this problem, together with some approaches towards solving them, with an emphas...... on an approach based on the CMfinder CMfinder program as a case study. Applications to genomic screens for novel de novo structured ncRNA ncRNA s, including structured RNA elements in untranslated portions of protein-coding genes, are presented.......De novo discovery of "motifs" capturing the commonalities among related noncoding ncRNA structured RNAs is among the most difficult problems in computational biology. This chapter outlines the challenges presented by this problem, together with some approaches towards solving them, with an emphasis...

  20. Defining the maize transcriptome de novo using deep RNA-Seq

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Jeffrey; Gross, Stephen; Choi, Cindy; Zhang, Tao; Lindquist, Erika; Wei, Chia-Lin; Wang, Zhong

    2011-06-01

    De novo assembly of the transcriptome is crucial for functional genomics studies in bioenergy research, since many of the organisms lack high quality reference genomes. In a previous study we successfully de novo assembled simple eukaryote transcriptomes exclusively from short Illumina RNA-Seq reads [1]. However, extensive alternative splicing, present in most of the higher eukaryotes, poses a significant challenge for current short read assembly processes. Furthermore, the size of next-generation datasets, often large for plant genomes, presents an informatics challenge. To tackle these challenges we present a combined experimental and informatics strategy for de novo assembly in higher eukaryotes. Using maize as a test case, preliminary results suggest our approach can resolve transcript variants and improve gene annotations.

  1. Defining the maize transcriptome de novo using deep RNA-Seq

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Jeffrey; Gross, Stephen; Choi, Cindy; Zhang, Tao; Lindquist, Erika; Wei, Chia-Lin; Wang, Zhong

    2011-06-02

    De novo assembly of the transcriptome is crucial for functional genomics studies in bioenergy research, since many of the organisms lack high quality reference genomes. In a previous study we successfully de novo assembled simple eukaryote transcriptomes exclusively from short Illumina RNA-Seq reads [1]. However, extensive alternative splicing, present in most of the higher eukaryotes, poses a significant challenge for current short read assembly processes. Furthermore, the size of next-generation datasets, often large for plant genomes, presents an informatics challenge. To tackle these challenges we present a combined experimental and informatics strategy for de novo assembly in higher eukaryotes. Using maize as a test case, preliminary results suggest our approach can resolve transcript variants and improve gene annotations.

  2. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

    DEFF Research Database (Denmark)

    Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent

    2017-01-01

    Hundreds of thousands of human genomes are now being sequenced to characterize genetic variation and use this information to augment association mapping studies of complex disorders and other phenotypic traits. Genetic variation is identified mainly by mapping short reads to the reference genome......-coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set...... or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high...

  3. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

    DEFF Research Database (Denmark)

    Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent

    2017-01-01

    Hundreds of thousands of human genomes are now being sequenced to characterize genetic variation and use this information to augment association mapping studies of complex disorders and other phenotypic traits. Genetic variation is identified mainly by mapping short reads to the reference genome...... or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high......-coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set...

  4. De novo synthesis of purine nucleotides in different fiber types of rat skeletal muscle

    International Nuclear Information System (INIS)

    Tullson, P.C.; John-Alder, H.; Hood, D.A.; Terjung, R.L.

    1986-01-01

    The contribution of de novo purine nucleotide synthesis to nucleotide metabolism in skeletal muscles is not known. The authors have determined rates of de novo synthesis in soleus (slow-twitch red), red gastrocnemius (fast-twitch red), and white gastrocnemius (fast-twitch white) using the perfused rat hindquarter. 14 C glycine incorporation into ATP was linear after 1 and 2 hours of perfusion with 0.2 mM added glycine. The intracellular (I) and extracellular (E) specific activity of 14 C glycine was determined by HPLC of phenylisothiocyanate derivatives of neutralized PCA extracts. The rates of de novo synthesis when expressed relative to muscle ATP content show slow and fast-twitch red muscles to be similar and about twice as great as fast-twitch white muscles. This could represent a greater turnover of the adenine nucleotide pool in more oxidative red muscle types

  5. A Pareto Algorithm for Efficient De Novo Design of Multi-functional Molecules.

    Science.gov (United States)

    Daeyaert, Frits; Deem, Micheal W

    2017-01-01

    We have introduced a Pareto sorting algorithm into Synopsis, a de novo design program that generates synthesizable molecules with desirable properties. We give a detailed description of the algorithm and illustrate its working in 2 different de novo design settings: the design of putative dual and selective FGFR and VEGFR inhibitors, and the successful design of organic structure determining agents (OSDAs) for the synthesis of zeolites. We show that the introduction of Pareto sorting not only enables the simultaneous optimization of multiple properties but also greatly improves the performance of the algorithm to generate molecules with hard-to-meet constraints. This in turn allows us to suggest approaches to address the problem of false positive hits in de novo structure based drug design by introducing structural and physicochemical constraints in the designed molecules, and by forcing essential interactions between these molecules and their target receptor. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. The language of human law in the thought of Francisco Suárez

    Directory of Open Access Journals (Sweden)

    Fernando Centenera Sánchez-Seco

    2018-05-01

    Full Text Available The subject of this article is the language of human law in the thought of Francisco Suárez. Its chief focus is on the Treatise on Laws and on God the Lawgiver and its views on the prescriptive nature of legislative language, written and spoken language, the lexical-semantic level, and linguistic clarity from the viewpoints of convenience, the essence of the law and justice. The issues Suárez deals with in relation to these points have continued to attract attention up to the present day, and a reading of the Treatise confirms the impression that some of them are still valid. Accordingly, as well as setting out, describing and offering a guide to understanding Suárez ideas, the article offers a comparative and contemplative analysis of them, without forgetting that their author belonged to the early modern period.

  7. Maps of Quaternary Deposits and Liquefaction Susceptibility in the Central San Francisco Bay Region, California

    Science.gov (United States)

    Witter, Robert C.; Knudsen, Keith L.; Sowers, Janet M.; Wentworth, Carl M.; Koehler, Richard D.; Randolph, Carolyn E.; Brooks, Suzanna K.; Gans, Kathleen D.

    2006-01-01

    This report presents a map and database of Quaternary deposits and liquefaction susceptibility for the urban core of the San Francisco Bay region. It supercedes the equivalent area of U.S. Geological Survey Open-File Report 00-444 (Knudsen and others, 2000), which covers the larger 9-county San Francisco Bay region. The report consists of (1) a spatial database, (2) two small-scale colored maps (Quaternary deposits and liquefaction susceptibility), (3) a text describing the Quaternary map and liquefaction interpretation (part 3), and (4) a text introducing the report and describing the database (part 1). All parts of the report are digital; part 1 describes the database and digital files and how to obtain them by downloading across the internet. The nine counties surrounding San Francisco Bay straddle the San Andreas fault system, which exposes the region to serious earthquake hazard (Working Group on California Earthquake Probabilities, 1999). Much of the land adjacent to the Bay and the major rivers and streams is underlain by unconsolidated deposits that are particularly vulnerable to earthquake shaking and liquefaction of water-saturated granular sediment. This new map provides a consistent detailed treatment of the central part of the 9-county region in which much of the mapping of Open-File Report 00-444 was either at smaller (less detailed) scale or represented only preliminary revision of earlier work. Like Open-File Report 00-444, the current mapping uses geomorphic expression, pedogenic soils, inferred depositional environments, and geologic age to define and distinguish the map units. Further scrutiny of the factors controlling liquefaction susceptibility has led to some changes relative to Open-File Report 00-444: particularly the reclassification of San Francisco Bay mud (Qhbm) to have only MODERATE susceptibility and the rating of artificial fills according to the Quaternary map units inferred to underlie them (other than dams - adf). The two colored

  8. Francisco Ibarra Martínez: renovador de la pedagogía cubana

    Directory of Open Access Journals (Sweden)

    Lic. Osmar Oliva-Crespo

    2015-10-01

    Full Text Available The article entitled Francisco Ibarra Martínez: reformer of Cuban Pedagogy, is first of all a well deserved homage to one of the most important pedagogues of the republican period. His thought and his work are approached, from his initial stage of academic formation to his contributions to the educational cuban thought. Stands out his social dimension of his pedagogic work, his integration to the civic life of the city, his reforming vision of the practice of sports and study of the history of his country. Likewise, we refer to his contributions to the historiography as a science, the journalism and his concern for the social and political destination of the country. For this reason this work has among its contributions the treatment to the local history from the specific fild of pedagogy and education, modestly contributing to the rescue of historic memory.

  9. What We Have Learned from San Francisco Declaration on Research Assessment and Leiden Manifesto?

    Directory of Open Access Journals (Sweden)

    Carey Ming-Li Chen

    2017-03-01

    Full Text Available In recent years, the research performance evaluation of members of the academic community conducted by government or institutions has been applied with multiple indicators and peer review, however, there are many controversies about the design and application of research evaluation indicators. This article aims to introduce the development process of San Francisco Declaration on Research Assessment (DORA and Leiden Manifesto and summarize their contents of guidelines and attempts to compare the differences between these two documents. It hopes that this article can arise the attention and reflection of research evaluation indicators and relevant issues from Taiwan academic community to reach consensus of utilization of research evaluation indicators. It will be beneficial to develop the version of declaration with local characteristics in the future.

  10. Masculinity and undocumented labor migration: injured latino day laborers in San Francisco

    Science.gov (United States)

    Walter, Nicholas; Bourgois, Philippe; Loinaz, H. Margarita

    2009-01-01

    Drawing on data collected through clinical practice and ethnographic fieldwork, this study examines the experience of injury, illness and disability among undocumented Latino day laborers in San Francisco. We demonstrate how constructions of masculine identity organize the experience of embodied social suffering among workers who are rendered vulnerable by the structural conditions of undocumented immigrant status. Theoretical concepts from critical medical anthropology and gender studies extend the scholarly analysis of structural violence beyond the primarily economic to uncover how it is embodied at the intimate level as a gendered experience of personal and familial crisis, involving love, respect, betrayal and patriarchal failure. A clinical ethnographic focus on socially structured patriarchal suffering elucidates the causal relationship between macro-forces and individual action with a fuller appreciation of the impact of culture and everyday lived experience. PMID:15210088

  11. Francisco Mejía: el testimonio de una sociedad que se complace

    Directory of Open Access Journals (Sweden)

    Carlos José Restrepo

    1986-10-01

    Full Text Available Hace unos dos años la familia Mejía donó al Faes (Fundación Antioqueña para los Estudios Sociales parte de los archivos fotográficos de Francisco Mejía (1899-1979, concretamente lo que podríamos llamar su archivo comercial en contraposición al de sus retratos de gabinete. Compuesto por unos siete mil negativos de diferentes materiales (vidrio, nitrato y acetato de celulosa, su calidad y variedad fueron motivo para que el Banco de la República resolviera apoyar el trabajo de identificación, procesamiento y preservación, labor llevada a cabo por el Centro de Memoria Visual de Medellín, que forma parte del Faes.

  12. Francisco de Miranda: Precursor de la independencia o espía al servicio de Inglaterra

    Directory of Open Access Journals (Sweden)

    Ángel Rafael Lombardi Boscán

    2006-09-01

    Full Text Available Francisco de Miranda es una de las grandes figuras emblemticas de la Historia de Venezuela. En nuestro medio le consideramos el adalid de la libertad continental en contra de la Monarquía hispnica. Hace doscientos años que intentó invadir a Venezuela y fracasó (1806; aunque contribuyó a crear las condiciones para la transición de colonia a republica. Aquí llevamos a cabo un acercamiento a su vida como conspirador bajo la dicotomía y paradoja de servir tanto a los intereses geopolíticos ingleses como a la causa de la libertad republicana.

  13. 1993 Annual Report: San Francisco estuary regional monitoring program for trace substances

    Science.gov (United States)

    Thompson, B.; Lacy, Jessica; Hardin, Dane; Grovhaug, Tom; Taberski, K.; Jassby, Alan D.; Cloern, James E.; Caffrey, J.; Cole, B.; Schoellhamer, David H.

    1993-01-01

    This first annual report of the San Francisco Estuary Regional Monitoring Program contains the results of monitoring measurements made in 1993. Measurements of conventional water quality parameters and trace contaminant concentrations were made at 16 stations throughout the Estuary three times during the year: the wet period (March), during declining Delta outflow (May), and during the dry period (September). Water toxicity tests were conducted at 8 of those stations. Measurements of sediment quality and contaminant concentrations were made at the same 16 stations during the wet and dry sampling periods. Sediment toxicity was measured at 8 of those stations. Transplanted, bagged bivalve bioaccumulation and condition was measured at 11 stations during the wet and dry sampling periods.

  14. La desconocida historia de la construcción de la iglesia de San Francisco

    Directory of Open Access Journals (Sweden)

    Susan V. Webster

    2012-07-01

    Full Text Available El presente artículo ofrece una nueva cronología e historia de la construcción de la iglesia de San Francisco de Quito a través de documentos históricos inéditos que demuestran, contrariamente a lo postulado en la historiografìa tradicional, que la actual iglesia no fue construida en el siglo XVI. El estudio ilustra los participantes y el proceso de construcción, empleando documentos, planos e imágenes. Se abarcan temas de autoría, particularmente las identidades de los diseñadoresy constructores, y se ofrece una reconsideración del legado historiográfico del imponente templo franciscano a la vista de la nueva documentación

  15. BRICKS, BRANDING, AND THE EVERYDAY: DEFINING GREATNESS AT THE UNITED NATIONS PLAZA IN SAN FRANCISCO

    Directory of Open Access Journals (Sweden)

    Georgia Lindsay

    2017-07-01

    Full Text Available After over a decade of reports, designs, and public outreach, the United Nations Plaza in San Francisco was dedicated in 1976. Using historical documents such as government reports, design guidelines, letters, meeting minutes, and newspaper articles from archives, I argue that while the construction of the UN Plaza has failed to completely transform the social and economic life of the area, it succeeds in creating a genuinely public space. The history of the UN Plaza can serve both as a cautionary tale for those interested in changing property values purely through changing design, and as a standard of success in making a space used by a true cross-section of urban society.

  16. NA BACIA DO RIO SÃO FRANCISCO, EM MINAS GERAIS

    Directory of Open Access Journals (Sweden)

    Lucas Rezende Gomide

    2006-01-01

    Full Text Available The objectives of this study were: to compare and to apply indices that quantify diversity, equability and similarity in the studied area; to identify possible diversity gradients, and to apply multivariate analysis to create dendrograms of similarity. The studied area was composed of 20 native forest fragments sited in riparian permanent preservation areas along the basin of São Francisco River, in Minas Gerais. The diversity presented a large variation according to all indices: Shannon: 2,176 to 4,389; Simpson: 0,019 to 0,206; Mixture quotient: 0,029 to 0,166, Equability 0,625 to 0,875. The floristic similarity among fragments using the Jaccard and Simpson quotients formed 5 and 4 floristic groups, respectively, with a cut level of 25%.

  17. Francisco Prat Puig: His pedagogical praxis at the Universidad de Oriente

    Directory of Open Access Journals (Sweden)

    María Cristina Hierrezuelo-Planas

    2017-05-01

    Full Text Available Doctor Francisco Prat Puig was one of the spanish intellectualist who sheltered in the Island of Cuba after the falling down of the Spanish Republic and in 1948 was part of the staff of professors of the recently founded Universidad de Oriente. He developed a teaching process which was centered on instruction through education and which followed the transmission and formation of values departing from his personal behavior and attitude. This took peace until his death in may, 1997. These aspect constitute one of the mastery strategies of the High Level Education Ministry of Cuba. The fact that most of his educational performance was done by the time when these aspect were not deeply applied, gives his pedagogical praxis a precursory character.

  18. User's guide to the LIRAQ model: an air pollution model for the San Francisco Bay Area

    International Nuclear Information System (INIS)

    MacCracken, M.C.

    1975-01-01

    The Livermore Regional Air Quality (LIRAQ) model comprises a set of computer programs that have been integrated into an easily used tool for the air quality planner. To assemble and modify the necessary data files and to direct model execution, a problem formulation program has been developed that makes possible the setup of a wide variety of studies involving perturbation of the emission inventory, changes to the initial and boundary conditions, and different choices of grid size and problem domain. In addition to describing the types of air quality problems for which the LIRAQ model may be used, this User's Guide provides detailed information on how to set up and conduct model simulations. Also included are descriptions of the formats of input data files so that the LIRAQ model may be applied to regions other than the San Francisco Bay Area

  19. Modeling Sulfides, pH and Hydrogen Sulfide Gas in the Sewers of San Francisco

    DEFF Research Database (Denmark)

    Vollertsen, Jes; Revilla, Nohemy; Hvitved-Jacobsen, Thorkild

    2015-01-01

    An extensive measuring campaign targeted on sewer odor problems was undertaken in San Francisco. It was assessed whether a conceptual sewer process model could reproduce the measured concentrations of total sulfide in the wastewater and H2S gas in the sewer atmosphere, and to which degree...... such simulations have potential for further improving odor and sulfide management. The campaign covered measurement of wastewater sulfide by grab sampling and diurnal sampling, and H2S gas in the sewer atmosphere was logged. The tested model was based on the Wastewater Aerobic/Anaerobic Transformations in Sewers...... (WATS) sewer process concept, which never had been calibrated to such an extensive dataset. The study showed that the model was capable of reproducing the general levels of wastewater sulfide, wastewater pH, and sewer H2S gas. It could also reproduce the general variability of these parameters, albeit...

  20. Polychlorinated biphenyls in the exterior caulk of San Francisco Bay Area buildings, California, USA.

    Science.gov (United States)

    Klosterhaus, Susan; McKee, Lester J; Yee, Donald; Kass, Jamie M; Wong, Adam

    2014-05-01

    Extensive evidence of the adverse impacts of polychlorinated biphenyls (PCBs) to wildlife, domestic animals, and humans has now been documented for over 40 years. Despite the ban on production and new use of PCBs in the United States in 1979, a number of fish consumption advisories remain in effect, and there remains considerable uncertainty regarding ongoing environmental sources and management alternatives. Using a blind sampling approach, 25 caulk samples were collected from the exterior of ten buildings in the San Francisco Bay Area and analyzed for PCBs using congener-specific gas chromatography-mass spectrometry (GC-MS) and chlorine using portable X-ray fluorescence (XRF). PCBs were detected in 88% of the caulk samples collected from the study area buildings, with 40% exceeding 50 ppm. Detectable PCB concentrations ranged from 1 to 220,000 ppm. These data are consistent with previous studies in other cities that have identified relatively high concentrations of PCBs in concrete and masonry buildings built between 1950 and 1980. Portable XRF was not a good predictor of the PCB content in caulk and the results indicate that portable XRF analysis may only be useful for identifying caulk that contains low concentrations of Cl (≤ 10,000 ppm) and by extension low or no PCBs. A geographic information system-based approach was used to estimate that 10,500 kg of PCBs remain in interior and exterior caulk in buildings located in the study area, which equates to an average of 4.7 kg PCBs per building. The presence of high concentrations in the exterior caulk of currently standing buildings suggests that building caulk may be an ongoing source of PCBs to the San Francisco Bay Area environment. Further studies to expand the currently small international dataset on PCBs in caulking materials in buildings of countries that produced or imported PCBs appear justified in the context of both human health and possible ongoing environmental release. Copyright © 2014 Elsevier

  1. Improved Storm Monitoring and Prediction for the San Francisco Bay Area

    Science.gov (United States)

    Cifelli, R.; Chandrasekar, V.; Anderson, M.; Davis, G.

    2017-12-01

    The Advanced Quantitative Precipitation Information (AQPI) System is a multi-faceted project to improve precipitation and hydrologic monitoring, prediction, and decision support for the San Francisco Bay Area. The Bay Area faces a multitude of threats from extreme events, including disrupted transportation from flooded roads and railroad lines, water management challenges related to storm water, river and reservoir management and storm-related damage demanding emergency response. The threats occur on spatial scales ranging from local communities to the entire region and time scales ranging from hours to days. These challenges will be exacerbated by future sea level rise, more extreme weather events and increased vulnerabilities. AQPI is a collaboration of federal, state and local governments with assistance from the research community. Led by NOAA's Earth System Research Laboratory, in partnership with the Cooperative Institute for Research in the Atmosphere, USGS, and Scripps, AQPI is a four-year effort funded in part by a grant from the California Department of Water Resource's Integrated Regional Water Management Program. The Sonoma County Water Agency is serving as the local sponsor of the project. Other local participants include the Santa Clara Valley Water District, San Francisco Public Utilities Commission, and the Bay Area Flood Protection Agencies Association. AQPI will provide both improved observing capabilities and a suite of numerical forecast models to produce accurate and timely information for benefit of flood management, emergency response, water quality, ecosystem services, water supply and transportation management for the Bay Area. The resulting information will support decision making to mitigate flood risks, secure water supplies, minimize water quality impacts to the Bay from combined sewer overflows, and have improved lead-time on coastal and Bay inundation from extreme storms like Atmospheric Rivers (ARs). The project is expected to

  2. Unmet healthcare need among women who use methamphetamine in San Francisco.

    Science.gov (United States)

    Powelson, Elisabeth; Lorvick, Jennifer; Lutnick, Alexandra; Wenger, Lynn; Klausner, Jeffery; Kral, Alex H

    2014-02-01

    Methamphetamine use has increased substantially in the United States since the 1990s. Few studies have examined the healthcare service needs of women who use methamphetamine. This study describes unmet medical needs in a community-based sample of women who use methamphetamine in San Francisco, CA. Women who use methamphetamine were recruited in San Francisco and participated in a computer-assisted survey (N = 298 HIV-negative women). Multivariate analysis was performed to explore associations among sociodemographic variables, drug use, use of health and social services, and unmet healthcare need across three domains: chronic health problems, dermatologic problems, and women's preventive healthcare. Sixty-nine percent of participants reported a need for care for a chronic health condition, and 31% of them had an unmet need for care, in the last six months. Thirty-five percent of participants reported a need for dermatologic healthcare, and 66% had an unmet need for care in the last 6 months. Ninety-two percent of participants reported a need for women's preventive healthcare and 46% had an unmet need for care in the last year. Women who reported having a healthcare provider had lower odds of reporting an unmet need for a chronic health condition or women's preventive healthcare. Women who used a case manager had lower odds of having an unmet need for dermatologic care. A significant proportion of women who use methamphetamine in this sample had an unmet need for women's preventive healthcare, and overall these women had a significant unmet need for healthcare. These findings suggest that contact with a healthcare provider or a caseworker could help to expand access to healthcare for this vulnerable population.

  3. Pedro de Valencia, Francisco de Gurmendi and the Plomos de Granada

    Directory of Open Access Journals (Sweden)

    Magnier, Grace

    2003-12-01

    Full Text Available The Inquisition in 1618 seized all the papers of Pedro de Valencia, renowned humanist, biblical scholar and chronicler of Philip III. The papers of other members of his circle were also confiscated. In this article I examine the two most important texts: Sobre el pergamino y láminas de Granada of Valencia and a Libelo Segundo of Francisco de Gurmendi, interpreter of Oriental languages for Philip III. The article is structured around Gurmendi's response to a memorial published in 1617 by Archbishop Pedro de Castro in defence of one of his translators. Gurmendi, working from his translation of the first two Lead Books, shows how these contain heretical ideas on the Trinity and how the memorialista has mistranslated many passages.

    En 1618 la Inquisición confiscó todos los papeles de Pedro de Valencia, humanista insigne, exegeta bíblico y cronista del reino y de las Indias de Felipe III. También confiscó los papeles de otros miembros de su círculo. En este artículo examino los dos textos más importantes: Sobre el pergamino y láminas de Granada de Valencia y un Libelo segundo de Francisco de Gurmendi, intérprete en lenguas orientales del rey. El artículo se centra en la respuesta de Gurmendi a un memorial del Arzobispo Pedro de Castro en el que se defiende a uno de sus traductores. Partiendo de su traducción de los dos primeros libros plúmbeos, Gurmendi muestra las herejías trinitarias que éstos contienen y cómo el memorialista ha traducido mal muchos pasajes.

  4. An Introduction to the San Francisco Estuary Tidal Wetlands Restoration Series

    Directory of Open Access Journals (Sweden)

    Larry R. Brown

    2003-10-01

    Full Text Available Restoration of tidal wetlands may provide an important tool for improving ecological health and water management for beneficial uses of the San Francisco Estuary (hereafter “Estuary”. Given the large losses of tidal wetlands from San Francisco Bay and the Sacramento-San Joaquin Delta in the last 150 years, it seems logical to assume that restoring tidal wetlands will have benefits for a variety of aquatic and terrestrial native species that have declined during the same time period. However, many other changes have also occurred in the Estuary concurrent with the declines of native species. Other factors that might be important in species declines include the effects of construction of upstream dams, large and small water diversions within the Sacramento-San Joaquin Delta, agricultural pesticides, trace elements from industrial and agricultural activities, and invasions of alien species. Discussions among researchers, managers, and stakeholders have identified a number of uncertainties regarding the potential benefits of tidal wetland restoration. The articles of the Tidal Wetlands Restoration Series address four major issues of concern. Stated as questions, these are: 1. Will tidal wetland restoration enhance populations of native fishes? 2. Will wetland restoration increase rates of methylation of mercury? 3. Will primary production and other ecological processes in restored tidal wetlands result in net export of organic carbon to adjacent habitats, resulting in enhancement of the food web? Will the carbon produced contribute to the formation of disinfection byproducts when disinfected for use as drinking water? 4. Will restored tidal wetlands provide long-term ecosystem benefits that can be sustained in response to ongoing physical processes, including sedimentation and hydrodynamics? Reducing the uncertainty surrounding these issues is of critical importance because tidal wetland restoration is assumed to be a critical tool for

  5. Religiosidad e identidad en San Francisco de Campeche. Siglos XVI y XVII

    Directory of Open Access Journals (Sweden)

    Rocher Salas, Adriana Delfina

    2006-12-01

    Full Text Available This study examines the problems concomitant to the development of a common identity among the Spanish settlers of San Francisco de Campeche during the Colonial period, with focus on the role played by religious elements in the shaping of this identity – in particular, the cult to the saints. An analysis of factors such as the characteristics of the saints in the neighborhood and local associations; processes of cult adoption, adaptation or dismissal; as well as the participation of the different local sectors in promoting the to their respective saints will be presented. This analysis will take into consideration the conflictive relationship between Spanish settlers and native people in Yucatán, a situation that prevented the using of aboriginal cultural elements in the shaping of a new identity

    Este trabajo estudia los problemas que acompañaron la gestación de una identidad propia y común para los residentes hispanos de la villa y puerto de San Francisco de Campeche durante el período colonial y la participación de elementos religiosos, particularmente el culto a los santos patronos, en el proceso. Teniendo como telón de fondo la peculiaridad de la región yucateca, donde una conflictiva relación entre españoles e indígenas impidió la utilización de elementos culturales prehispánicos en la formación de una conciencia identitaria, se analizan diversos factores, como las características de los santos tutelares de los barrios y de algunas corporaciones locales, los procesos de adopción, adaptación u olvido de sus cultos por parte del vecindario porteño y la participación de los diferentes sectores locales en la promoción de sus santos patronos.

  6. Literature Review of Unconsolidated Sediment in San Francisco Bay and Nearby Pacific Ocean Coast

    Directory of Open Access Journals (Sweden)

    Barry R. Keller

    2009-09-01

    Full Text Available A review of the geologic literature regarding sedimentation in the San Francisco Bay estuarine system shows that the main part of the bay occupies a structural tectonic depression that developed in Pleistocene time. Eastern parts, including San Pablo Bay and Suisun Bay, have had sedimentation throughout late Mesozoic and Tertiary. Carquinez Strait and the Golden Gate may represent antecedent stream erosion. Sedimentation has included estuarine, alluvial, and eolian deposition. The ages of estuarine deposition includes the modern high sea level stand and earlier Pleistocene interglacial periods. Sediment sources can be generally divided into the Coast Ranges, particularly the Franciscan Complex, and “Sierran.” Much of the estuarine system is floored by very fine sediment, with local areas of sand floor. Near the Golden Gate, sediment size decreases in both directions away from the deep channel. Bedforms include sand waves (submarine dunes, flat beds, and rock and boulders. These are interpreted in terms of dominant transport directions. Near the Golden Gate is an ebb-tidal delta on the outside (including San Francisco bar and a flood-tidal delta on the inside (parts of Central Bay. The large tidal prism causes strong tidal currents, which in the upper part of the estuary are normally much stronger than river currents, except during large floods. Cultural influences have altered conditions, including hydraulic mining debris, blasting of rocks, dredging of navigation channels, filling of the bay, and commercial sand mining. Many of these have served to decrease the tidal prism, correspondingly decreasing the strength of tidal currents.

  7. Application of INAA to provenance study of ceramics from Baixo Sao Francisco River, Sergipe, Brazil

    International Nuclear Information System (INIS)

    Santos, J.O.; Munita, C.S.; Toyota, Rosimeiri G.; Vergne, C.

    2007-01-01

    The study of the physical and chemical characteristics of crafts, in association with historical and archaeological research, has allowed for the reconstruction of ancient community habits. Archaeological studies include several techniques to reconstruct ancient cultures. Since ceramics represent a sophisticated merging of previously separate domains of human knowledge and experience, these objects are studied by means of archaeometric methods. In recent years an interdisciplinary research program was started between Museu Arqueologico de Xingo (MAX) and Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP) to study the ancient ceramist cultures from Xingo region, located in Sergipe, Brazilian Northeast. Recent studies conducted in the area have showed the existence of an independent ceramist group without relation to the ceramist group well established in the Brazilian Northeast, Tupiguarani and Aratu. Instrumental neutron activation analysis, INAA, is a suitable technique for provenance studies. In this work the chemical composition of 103 samples: 30 clays and 73 ceramics from Barracao archaeological site, from Baixo Sao Francisco, were analyzed. This analysis allowed for the definition of compositional groups of ceramics according to the chemical similarities of ceramic paste, which reveals the raw material composition used in the manufacturing process by prehistoric man. The outliers were identified by means robust Mahalanobis distance. The results were interpreted by means of cluster analysis, principal components analysis and discriminant analysis. The results obtained in this work, in association with archaeological information, allowed for the identification of the ceramic groups in relation to the ceramist occupations of the Xingo area. This work contributes for the reconstruction of the Baixo Sao Francisco region communities and for the reconstitution of the Brazilian Northeast ceramist population. (author)

  8. Structure and flow-induced variability of the subtidal salinity field in northern San Francisco Bay

    Science.gov (United States)

    Monismith, Stephen G.; Kimmerer, W.; Burau, J.R.; Stacey, M.T.

    2002-01-01

    The structure of the salinity field in northern San Francisco Bay and how it is affected by freshwater flow are discussed. Two datasets are examined: the first is 23 years of daily salinity data taken by the U.S. Bureau of Reclamation along the axis of northern San Francisco Bay: the second is a set of salinity transects taken by the U.S. Geological Survey between 1988 and 1993. Central to this paper is a measure of salinity intrusion. X2: the distance from the Golden Gate Bridge to where the bottom salinity is 2 psu. Using X2 to scale distance, the authors find that for most flow conditions, the mean salinity distribution of the estuary is nearly self-similar with a salinity gradient in the center 70% of the region between the Golden Gate and X2 that is proportional to X2-1. Analysis of covariability of Q and X2 showed a characteristics timescale of adjustment of the salinity field of approximately 2 weeks. The steady-state response deduced from the X2 time series implies that X2 is proportional to riverflow to the 1/7 power. This relation, which differs from the standard 1/3 power dependence that is derived theoretically assuming constant exchange coefficients, shows that the upstream salt flux associated with gravitational circulation is more sensitive to the longitudinal salinity gradient than theory supposes. This is attributed to the strengthening of stratification caused by the stronger longitudinal salinity gradient that accompanies larger river flows.

  9. State of transition: Marijuana use among young adults in the San Francisco Bay Area.

    Science.gov (United States)

    Holmes, Louisa M; Popova, Lucy; Ling, Pamela M

    2016-09-01

    California may vote on marijuana legalization in 2016. Young adults have the highest rates of marijuana use, but little is known about the correlates of use in this age group, including factors that may be affected by policy change. We investigated whether there are differences in marijuana use by sociodemographic characteristics, psychological distress, loneliness and social support, controlling for risk factors such as alcohol and cigarette use as well as perceived harm of marijuana. Bivariate and multivariable analysis of past 30day marijuana use using the 2014 San Francisco Bay Area Young Adult Health Survey, a probabilistic multi-mode survey of (N=1324) young adults (aged 18-26years) residing in Alameda and San Francisco Counties, stratified by race/ethnicity. 291 (27%) sample participants reported current marijuana use. Compared to non-Hispanic Whites (referent) Asian/Pacific Islander respondents were less likely to use marijuana (AOR, 0.42; 95% CI, 0.22-0.80) while multiracial participants were twice as likely (AOR, 2.27; 95% CI, 1.06-4.85). Psychological distress was not related to marijuana use, but social support (AOR, 1.42; 95% CI, 1.08-1.88) and loneliness (AOR, 1.42; 95% CI, 1.09-1.86) were. Perceived harm of marijuana was inversely related to marijuana use (AOR, 0.60; 95% CI, 0.51-0.70), while smoking cigarettes (AOR, 3.95; 95% CI, 2.28-6.84) and binge drinking (AOR, 1.13; 95% CI, 1.03-1.24) were positively related. Legalization policies should include public education campaigns addressing potential harms of marijuana use particularly targeting multiracial young adults who also engage in other risk behaviors, such as cigarette smoking and binge drinking. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Distribution and Invasion Potential of Limonium ramosissimum subsp. provinciale in San Francisco Estuary Salt Marshes

    Directory of Open Access Journals (Sweden)

    Gavin Archbald

    2014-06-01

    Full Text Available Non-native sea lavenders (Limonium spp. are invasive in salt marshes of southern California and were first documented in the San Francisco Estuary (the estuary in 2007. In this study, we mapped distributions of L. ramosissimum subsp. provinciale (LIRA and L. duriusculum within the estuary and investigated how the invasion potential of the more common species, LIRA, varies with elevation and edaphic conditions. We contacted colleagues and conducted field searches to find and then map sea lavender populations. In addition, we measured LIRA’s elevational range at three salt marshes. Across this range we measured (1 soil properties: salinity, moisture, bulk density, and texture; and (2 indicators of invasion potential: LIRA size, seed production, percent cover, spread (over 1 year, recruitment, and competition with native halophytes (over 6 months. We found LIRA in 15,144 m2 of upper salt marsh habitat in central and south San Francisco bays and L. duriusculum in 511 m2 in Richardson and San Pablo bays. LIRA was distributed from mean high water (MHW to 0.42 m above mean higher high water (MHHW. In both spring and summer, soil moisture and salinity were lowest at higher elevations within LIRA’s range, which corresponded with greater rosette size, inflorescence and seed production (up to 17,400 seeds per plant, percent cover, and recruitment. LIRA cover increased on average by 11% in 1 year across marshes and elevations. Cover of the native halophytes Salicornia pacifica, Jaumea carnosa, and Distichlis spicata declined significantly at all elevations if LIRA were present in plots (over a 6-month, fall–winter period. Results suggest LIRA’s invasion potential is highest above MHHW where salinity and moisture are lower, but that LIRA competes with native plants from MHW to above MHHW. We recommend removal efforts with emphasis on the salt marsh-terrestrial ecotone where LIRA seed output is highest.

  11. Francisco Antonio Zea: periodista, botánico y político

    Directory of Open Access Journals (Sweden)

    Soto Arango, Diana E.

    1996-06-01

    Full Text Available This work analyzes the journalistic facet of Francisco Antonio Zea, whose first article, «Avisos de Hebephilo», was published in 1791 in the Papel Periódico de la ciudad de Santa Fé de Bogotá. His interest for the press shows at his stage of student in the National Institute of France, but won't be up to 1803, at his return to Madrid, when he proves his talent for the organization and journalistic administration on The Mercury and on the Gazette de Madrid. Later on, being manager of the Royal Botanical Garden of Madrid, he shares the management of the Semanario de Agricultura y Artes, and, finally, in 1818 establishes and directs the Venezuelan Correo del Orinoco.

    Este trabajo analiza la faceta periodística de Francisco Antonio Zea, cuyo primer artículo, «Avisos de Hebephilo», se publicó en 1791 en el Papel Periódico de la ciudad de Santa Fé de Bogota. Su interés por la prensa se manifiesta en su etapa de estudiante en el Instituto Nacional de Francia, pero no será hasta 1803, a su regreso a Madrid, cuando evidencie sus dotes para la organización y dirección periodísticas en El Mercurio y en la Gaceta de Madrid. Posteriormente, siendo director del Real Jardín Botánico de Madrid, comparte la dirección del Semanario de Agricultura y Artes, y, finalmente, en 1818 funda y dirige el venezolano Correo del Orinoco.

  12. Seismic velocities and geologic logs from boreholes at three downhole arrays in San Francisco, California

    Science.gov (United States)

    Gibbs, James F.; Fumal, Thomas E.; Borcherdt, Roger D.; Warrick, Richard E.; Liu, Hsi-Ping; Westerlund, Robert E.

    1994-01-01

    The Loma Prieta earthquake of October 17, 1989 (1704 PST), has reinforced observations made by Wood and others (1908) after the 1906 San Francisco earthquake, that poor ground conditions (soft soil) increase the likelihood of shaking damage to structures. Since 1908 many studies (for example Borcherdt, 1970, Borcherdt and Gibbs, 1976, Borcherdt and Glassmoyer, 1992) have shown that soft soils amplify seismic waves at frequencies that can be damaging to structures. Damage in the City of San Francisco from the Loma Prieta earthquake was concentrated in the Marina District, the Embarcadero, and the China Basin areas. Each of these areas, to some degree, is underlain by soft soil deposits. These concentrations of damage raise important questions regarding the amplification effects of such deposits at damaging levels of motion. Unfortunately, no strong-motion recordings were obtained in these areas during the Loma Prieta earthquake and only a limited number (< 10) have been obtained on other soft soil sites in the United States. Consequently, important questions exist regarding the response of such deposits during damaging earthquakes, especially questions regarding the nonlinear soil response. Towards developing a data set to address these important questions, borehole strong-motion arrays have been installed at three locations. These arrays consist of groups of wide-dynamic-range pore-pressure transducers and three-component accelerometers, the outputs of which are recorded digitally. The arrays are designed to provide an integrated set of data on ground shaking, liquifaction-induced ground failure, and structural response. This report describes the detailed geologic, seismic, and material-property determinations derived at each of these sites.

  13. A Terra em Transe: o cosmopolitismo às avessas do cinema novo

    Directory of Open Access Journals (Sweden)

    Angela Prysthon

    2008-11-01

    Full Text Available Usando como referencial teórico os estudos culturais, este artigo analisa o cinema novo brasileiro como parte de uma estratégia terceiro mundista de conceber a cultura. A partir da emergência do conceito de terceiro mundo e das lutas de descolonização nos anos 1950 e 1960, a ideologia cosmopolita foi sendo vista pelos intelectuais de esquerda como a versão cultural da aliança com as forças hegemônicas da Europa e dos Estados Unidos. O projeto do cinema novo chama a atenção por suas afinidades ideológicas com o terceiro mundismo, mas, paradoxalmente, trazendo à tona uma polí­tica cosmopolita da periferia. Palavras-chave cinema novo, identidade, cultura brasileira, terceiro mundismo, estudos culturais. Abstract Using the cultural studies theoretical framework, this paper analyzes the cinema novo movement in Brazil as a part of the Third World conception of culture. Following the creation of the term "Third World" and the international politics of colonial independence of the 1950s and 1960s, a cosmopolitan attitude was seen by the intellectuals of the left as a cultural version of the alliance with the hegemonic forces of Europe and North America. Even though the cinema novo project can be associated with the ideology of an united Third World ,it brings about, paradoxically, a very cosmopolitan politics of the periphery. Key words cinema novo, identity, Brazilian culture, third world, cultural studies.

  14. Precise detection of de novo single nucleotide variants in human genomes.

    Science.gov (United States)

    Gómez-Romero, Laura; Palacios-Flores, Kim; Reyes, José; García, Delfino; Boege, Margareta; Dávila, Guillermo; Flores, Margarita; Schatz, Michael C; Palacios, Rafael

    2018-05-07

    The precise determination of de novo genetic variants has enormous implications across different fields of biology and medicine, particularly personalized medicine. Currently, de novo variations are identified by mapping sample reads from a parent-offspring trio to a reference genome, allowing for a certain degree of differences. While widely used, this approach often introduces false-positive (FP) results due to misaligned reads and mischaracterized sequencing errors. In a previous study, we developed an alternative approach to accurately identify single nucleotide variants (SNVs) using only perfect matches. However, this approach could be applied only to haploid regions of the genome and was computationally intensive. In this study, we present a unique approach, coverage-based single nucleotide variant identification (COBASI), which allows the exploration of the entire genome using second-generation short sequence reads without extensive computing requirements. COBASI identifies SNVs using changes in coverage of exactly matching unique substrings, and is particularly suited for pinpointing de novo SNVs. Unlike other approaches that require population frequencies across hundreds of samples to filter out any methodological biases, COBASI can be applied to detect de novo SNVs within isolated families. We demonstrate this capability through extensive simulation studies and by studying a parent-offspring trio we sequenced using short reads. Experimental validation of all 58 candidate de novo SNVs and a selection of non-de novo SNVs found in the trio confirmed zero FP calls. COBASI is available as open source at https://github.com/Laura-Gomez/COBASI for any researcher to use. Copyright © 2018 the Author(s). Published by PNAS.

  15. De novo mutations in ATP1A3 cause alternating hemiplegia of childhood

    DEFF Research Database (Denmark)

    Heinzen, Erin L; Swoboda, Kathryn J; Hitomi, Yuki

    2012-01-01

    and their unaffected parents to identify de novo nonsynonymous mutations in ATP1A3 in all seven individuals. In a subsequent sequence analysis of ATP1A3 in 98 other patients with AHC, we found that ATP1A3 mutations were likely to be responsible for at least 74% of the cases; we also identified one inherited mutation...... affecting the level of protein expression. This work identifies de novo ATP1A3 mutations as the primary cause of AHC and offers insight into disease pathophysiology by expanding the spectrum of phenotypes associated with mutations in ATP1A3....

  16. NovoTTF™-100A System (Tumor Treating Fields) transducer array layout planning for glioblastoma: a NovoTAL™ system user study.

    Science.gov (United States)

    Chaudhry, Aafia; Benson, Laura; Varshaver, Michael; Farber, Ori; Weinberg, Uri; Kirson, Eilon; Palti, Yoram

    2015-11-11

    Optune™, previously known as the NovoTTF-100A System™, generates Tumor Treating Fields (TTFields), an effective anti-mitotic therapy for glioblastoma. The system delivers intermediate frequency, alternating electric fields to the supratentorial brain. Patient therapy is personalized by configuring transducer array layout placement on the scalp to the tumor site using MRI measurements and the NovoTAL System. Transducer array layout mapping optimizes therapy by maximizing electric field intensity to the tumor site. This study evaluated physician performance in conducting transducer array layout mapping using the NovoTAL System compared with mapping performed by the Novocure in-house clinical team. Fourteen physicians (7 neuro-oncologists, 4 medical oncologists, and 3 neurosurgeons) evaluated five blinded cases of recurrent glioblastoma and performed head size and tumor location measurements using a standard Digital Imaging and Communications in Medicine reader. Concordance with Novocure measurement and intra- and inter-rater reliability were assessed using relevant correlation coefficients. The study criterion for success was a concordance correlation coefficient (CCC) >0.80. CCC for each physician versus Novocure on 20 MRI measurements was 0.96 (standard deviation, SD ± 0.03, range 0.90-1.00), indicating very high agreement between the two groups. Intra- and inter-rater reliability correlation coefficients were similarly high: 0.83 (SD ±0.15, range 0.54-1.00) and 0.80 (SD ±0.18, range 0.48-1.00), respectively. This user study demonstrated an excellent level of concordance between prescribing physicians and Novocure in-house clinical teams in performing transducer array layout planning. Intra-rater reliability was very high, indicating reproducible performance. Physicians prescribing TTFields, when trained on the NovoTAL System, can independently perform transducer array layout mapping required for the initiation and maintenance of patients on TTFields

  17. Empirical evidence for synchrony in the evolution of TB cases and HIV+ contacts among the San Francisco homeless.

    Directory of Open Access Journals (Sweden)

    Mojdeh Mohtashemi

    Full Text Available The re-emergence of tuberculosis (TB in the mid-1980s in many parts of the world, including the United States, is often attributed to the emergence and rapid spread of human immunodeficiency virus (HIV and acquired immunodeficiency syndrome (AIDS. Although it is well established that TB transmission is particularly amplified in populations with high HIV prevalence, the epidemiology of interaction between TB and HIV is not well understood. This is partly due to the scarcity of HIV-related data, a consequence of the voluntary nature of HIV status reporting and testing, and partly due to current practices of screening high risk populations through separate surveillance programs for HIV and TB. The San Francisco Department of Public Health, TB Control Program, has been conducting active surveillance among the San Francisco high-risk populations since the early 1990s. We present extensive TB surveillance data on HIV and TB infection among the San Francisco homeless to investigate the association between the TB cases and their HIV+ contacts. We applied wavelet coherence and phase analyses to the TB surveillance data from January 1993 through December 2005, to establish and quantify statistical association and synchrony in the highly non-stationary and ostensibly non-periodic waves of TB cases and their HIV+ contacts in San Francisco. When stratified by homelessness, we found that the evolution of TB cases and their HIV+ contacts is highly coherent over time and locked in phase at a specific periodic scale among the San Francisco homeless, but no significant association was observed for the non-homeless. This study confirms the hypothesis that the dynamics of HIV and TB are significantly intertwined and that HIV is likely a key factor in the sustenance of TB transmission among the San Francisco homeless. The findings of this study underscore the importance of contact tracing in detection of HIV+ individuals that may otherwise remain undetected, and

  18. Analysis of 60 706 Exomes Questions the Role of De Novo Variants Previously Implicated in Cardiac Disease

    DEFF Research Database (Denmark)

    Paludan-Müller, Christian; Ahlberg, Gustav; Ghouse, Jonas

    2017-01-01

    BACKGROUND: De novo variants in the exome occur at a rate of 1 per individual per generation, and because of the low reproductive fitness for de novo variants causing severe disease, the likelihood of finding these as standing variations in the general population is low. Therefore, this study...... sought to evaluate the pathogenicity of de novo variants previously associated with cardiac disease based on a large population-representative exome database. METHODS AND RESULTS: We performed a literature search for previous publications on de novo variants associated with severe arrhythmias...... trio studies (>1000 subjects). Of the monogenic variants, 11% (23/211) were present in ExAC, whereas 26% (802/3050) variants believed to increase susceptibility of disease were identified in ExAC. Monogenic de novo variants in ExAC had a total allele count of 109 and with ≈844 expected cases in Ex...

  19. Plankton data collected using net casts from the FRANCISCO DE ULLOA in the North Pacific Ocean from 15 July 1998 to 30 July 1998 (NODC Accession 0000911)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Plankton data were collected using net casts in the North Pacific Ocean from FRANCISCO DE ULLOA. Data were collected from 15 July 1998 to 30 July 1998. Data were...

  20. Zooplankton data collected using net casts from the FRANCISCO DE ULLOA in the North Pacific Ocean from 01 January 1999 to 31 January 1999 (NODC Accession 0000912)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Zooplankton data were collected using net casts in the North Pacific Ocean from FRANCISCO DE ULLOA. Data were collected from 01 January 1999 to 31 January 1999. Data...

  1. PCDD/F, PCB, HXCBZ, PAH, AND PM EMISSION FACTORS FOR FIREPLACE AND WOODSTOVE COMBUSTION IN THE SAN FRANCISCO BAY REGION

    Science.gov (United States)

    Emissions from residential fireplace and woodstove appliances burning fuels available from the San Francisco Bay area were sampled for polychlornated dibenzodioxins and dibenzofurans (PCDDs/Fs), polychlorinated biphenyls (PCBs), hexachlorobenzene (HxCBz), particulatematter (P...

  2. University of California San Francisco (UCSF-2): Expression Analysis of Superior Cervical Ganglion from Backcrossed TH-MYCN Transgenic Mice | Office of Cancer Genomics

    Science.gov (United States)

    The CTD2 Center at University of California San Francisco (UCSF-2) used genetic analysis of the peripheral sympathetic nervous system to identify potential therapeutic targets in neuroblastoma. Read the abstract Experimental Approaches Read the detailed Experimental Approaches

  3. EX1006 Hawaii to San Francisco Transit to Drydock (EX1006, EM302) on Okeanos Explorer in Hawaii, US West Coast

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Okeanos Explorer (EX) will transit from Honolulu, HI to San Francisco for the winter inport and drydock period. During the transit, the EX will perform 24-hour...

  4. ESCARABAJOS TIGRE (COLEOPTERA: CICINDELIDAE DEL MUSEO ENTOMOLÓGICO FRANCISCO LUÍS GALLEGO: NUEVOS REGISTROS PARA DEPARTAMENTOS DE COLOMBIA TIGER BEETLES (COLEOPTERA: CICINDELIDAE AT THE ENTOMOLOGICAL MUSEUM FRANCISCO LUÍS GALLEGO: NEW RECORDS

    Directory of Open Access Journals (Sweden)

    Manuel Alejandro Ramírez Mora

    2008-06-01

    Full Text Available Se registran por primera vez las especies de escarabajos tigre (Coleoptera: Cicindelidae presentes en el Museo Entomológico Francisco Luis Gallego (MEFLG. Se identificaron 167 especimenes distribuidos en ocho géneros y 27 especies, se reportan 24 nuevos registros para diferentes departamentos de Colombia. Se señalan aspectos importantes de la taxonomía y sistemática del grupo. Además, se presentan comentarios biológicos y de distribución de las especies.Tiger beetles (Coleoptera: Cicindelidae species at the Museo Entomológico Francisco Luis Gallego (MEFLG are registered by first time. 167 specimens in 8 genus and 27 species were identified, 24 new records for different Colombian states are reported. Some important aspects of the group’s taxonomy and systematic are pointed. Additionally, species’ biological and distributional comments are presented.

  5. Thermal modeling and geomorphology of the south border of the Sao Francisco Craton: thermochronology by fission tracks in apatites;Modelagem termica e geomorfologia da borda sul do Craton do Sao Francisco: termocronologia por tracos de fissao em apatita

    Energy Technology Data Exchange (ETDEWEB)

    Hackspacher, Peter Christian [UNESP, Rio Claro, SP (Brazil). Inst. de Geociencias e Ciencias Exatas; Godoy, Daniel Francoso de; Franco, Ana Olivia Barufi [UNESP, Rio Claro, SP (Brazil). Pos-Graduacao em Geologia Regional; Ribeiro, Luiz Felipe Brandini [NUCLEARGEO, Rio Claro, SP (Brazil); Hadler Neto, Julio Cesar [Universidade Estadual de Campinas (IFGW/UNICAMP), SP (Brazil). Inst. de Fisica Gleb Wataghin

    2007-12-15

    Recent developments in Fission Track thermochronology associated to mesozoic-cenozoic erosion and tectonic presented trough thematic maps (isotemperature), permit to model the landscape evolution in the southern border of the Sao Francisco craton, southeastern Brazil. Paleotemperature, obtained by fission track analysis in apatite, is closely related to geomorphologic interpretations. The area suffered a complex imprint of endogenous and exogenous processes resulting diversified and differentiated relieves. The landscape is strongly controlled by exhumation between Jurassic and Lower Cretaceous, uplift with tectonic denudation related to crustal heating at the Upper Cretaceous and reactivation of faults until the Miocene. This scenario is a result of reactivations of different brittle structures that accommodate the deformation in the southern border of the Sao Francisco craton. The landscape reflects denudations of up to 3 km with preserved remains of erosive surfaces in the topographical tops and chronocorrelates deposits in the basins of the region. (author)

  6. Long-read sequencing and de novo assembly of a Chinese genome

    Science.gov (United States)

    Short-read sequencing has enabled the de novo assembly of several individual human genomes, but with inherent limitations in characterizing repeat elements. Here we sequence a Chinese individual HX1 by single-molecule real-time (SMRT) long-read sequencing, construct a physical map by NanoChannel arr...

  7. A De novo Mutation in Dystrophin Causing Muscular Dystrophy in a Female Patient

    Directory of Open Access Journals (Sweden)

    Hao Yu

    2017-01-01

    Conclusions: We identified two novel de novo mutations of DMD gene in two Chinese pedigrees, one of which caused a female patient with muscular dystrophy. The mutational analysis is important for DMD patients and carriers in the absence of a family history. The NGS can help detect the mutations in MLPA-negative patients.

  8. Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven)

    DEFF Research Database (Denmark)

    Viuff, D.; Lauritzen, B.; Pusateri, A.E.

    2008-01-01

    BACKGROUND: A range of plasma volume expanders is used clinically, often in settings where haemostasis may already be impaired. The haemostatic agent, recombinant activated factor VII (rFVIIa, NovoSeven), may be used to improve haemostasis but potential interactions with different volume expanders...

  9. Optimization of treatment protocols to prevent de novo development of antibiotic resistance in Pseudomonas aeruginosa

    NARCIS (Netherlands)

    Feng, Yanfang

    2016-01-01

    The ever-increasing rate of drug resistant bacteria has been one of the most challenging problem worldwide. This thesis studied the following subjects with mostly the clinically leading pathogen, P. aeruginosa, as the model strain: de novo development of antibiotic resistance in patient during the

  10. Norgal: Extraction and de novo assembly of mitochondrial DNA from whole-genome sequencing data

    DEFF Research Database (Denmark)

    Al-Nakeeb, Kosai Ali Ahmed; Petersen, Thomas Nordahl; Sicheritz-Pontén, Thomas

    2017-01-01

    and performing a de novo assembly on a subset of reads that contains these k-mers. The method was applied to WGS data from a panda, brown algae seaweed, butterfly and filamentous fungus. We were able to extract full circular mitochondrial genomes and obtained sequence identities to the reference sequences...

  11. 76 FR 61103 - Draft Guidance for Industry and Food and Drug Administration Staff; De Novo Classification...

    Science.gov (United States)

    2011-10-03

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-D-0689] Draft Guidance for Industry and Food and Drug Administration Staff; De Novo Classification Process... appropriate, and other forms of information technology. Draft Guidance for Industry and Food and Drug...

  12. De novo post-pollen mitosis II tobacco pollen tube transcriptome

    Czech Academy of Sciences Publication Activity Database

    Hafidh, Said; Breznenová, Katarína; Honys, David

    2012-01-01

    Roč. 7, č. 8 (2012), s. 918-921 ISSN 1559-2316 R&D Projects: GA ČR GPP501/11/P321; GA ČR GA522/09/0858 Institutional research plan: CEZ:AV0Z50380511 Keywords : de novo pollen tube transcriptome * male gametophyte development * pollen tube growth Subject RIV: ED - Physiology

  13. De novo mutations of KIAA2022 in females cause intellectual disability and intractable epilepsy

    NARCIS (Netherlands)

    de Lange, Iris M; Helbig, Katherine L; Weckhuysen, Sarah; Møller, Rikke S; Velinov, Milen; Dolzhanskaya, Natalia; Marsh, Eric; Helbig, Ingo; Devinsky, Orrin; Tang, Sha; Mefford, Heather C; Myers, Candace T; van Paesschen, Wim; Striano, Pasquale; van Gassen, Koen; van Kempen, Marjan; de Kovel, Carolien G F; Piard, Juliette; Minassian, Berge A; Nezarati, Marjan M; Pessoa, André; Jacquette, Aurelia; Maher, Bridget; Balestrini, Simona; Sisodiya, Sanjay; Warde, Marie Therese Abi; De St Martin, Anne; Chelly, Jamel; van 't Slot, Ruben; Van Maldergem, Lionel; Brilstra, Eva H; Koeleman, Bobby P C

    2016-01-01

    BACKGROUND: Mutations in the KIAA2022 gene have been reported in male patients with X-linked intellectual disability, and related female carriers were unaffected. Here, we report 14 female patients who carry a heterozygous de novo KIAA2022 mutation and share a phenotype characterised by intellectual

  14. Inflammatory bowel disease after liver transplantation : Risk factors for recurrence and De novo disease

    NARCIS (Netherlands)

    Verdonka, RC; Dijkstra, G; Haagsma, EB; Shostrom, VK; Van den Berg, AP; Kleibeuker, JH

    Inflammatory bowel disease (IBD) is associated with primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) and can recur or develop de novo after orthotopic liver transplantation (OLT). The aim of this study was to investigate the incidence and severity of IBD after liver

  15. Drug-Eluting Balloons in the Treatment of Coronary De Novo Lesions

    DEFF Research Database (Denmark)

    Richelsen, Rasmus Kapalu Broge; Overvad, Thure Filskov; Jensen, Svend Eggert

    2016-01-01

    Drug-eluting balloons (DEBs) have emerged as a new application in percutaneous coronary intervention. DEBs have proven successful in the treatment of in-stent restenosis, but their role in de novo lesions is less clear. This paper provides a review of the current studies where DEBs have been used...

  16. Whole-genome sequencing in autism identifies hot spots for de novo germline mutation

    DEFF Research Database (Denmark)

    Michaelson, Jacob J.; Shi, Yujian; Gujral, Madhusudan

    2012-01-01

    De novo mutation plays an important role in autism spectrum disorders (ASDs). Notably, pathogenic copy number variants (CNVs) are characterized by high mutation rates. We hypothesize that hypermutability is a property of ASD genes and may also include nucleotide-substitution hot spots. We...

  17. The Key Drivers behind Novo Nordisk’s Growth in the Diabetes Market in China

    Directory of Open Access Journals (Sweden)

    Hind Louiza CHITOUR

    2013-12-01

    Full Text Available To enter the Chinese Pharmaceutical market, “Big Pharma” has adopted different strategies to tackle the challenges specific to the country in terms of size, demographics, specific sales channels and logistics adjustments. While the majority of Global Pharmaceutical players have opted for an aggressive M&A approach to penetrate the Chinese market and gain local insight; the Danish Novo Nordisk has instead chosen a strategy focusing on innovation and developing its R&D structure to capitalize on the local talent pool. To illustrate Novo Nordisk’s growth strategy in the Mainland, we analyzed its competitiveness in the diabetes market by demonstrating the key drivers behind this success. We applied a various set of tools for this research: Novo Nordisk, Dong Bao Pharmaceutical executives’ interviews and personal observations accounting for the primary data, we also reviewed secondary data to perform a PEST analysis in addition to Porter’s competitive advantage model in order to extract the reasons behind Novo Nordisk’s marching success in the Mainland.

  18. A glance at quality score: implication for de novo transcriptome reconstruction of Illumina reads

    Directory of Open Access Journals (Sweden)

    Stanley Kimbung Mbandi

    2014-02-01

    Full Text Available Downstream analyses of short-reads from next-generation sequencing platforms are often preceded by a pre-processing step that removes uncalled and wrongly called bases. Standard approaches rely on their associated base quality scores to retain the read or a portion of it when the score is above a predefined threshold. It is difficult to differentiate sequencing error from biological variation without a reference using quality scores. The effects of quality score based trimming have not been systematically studied in de novo transcriptome assembly. Using RNA-Seq data produced from Illumina, we teased out the effects of quality score base filtering or trimming on de novo transcriptome reconstruction. We showed that assemblies produced from reads subjected to different quality score thresholds contain truncated and missing transfrags when compared to those from untrimmed reads. Our data supports the fact that de novo assembling of untrimmed data is challenging for de Bruijn graph assemblers. However, our results indicates that comparing the assemblies from untrimmed and trimmed read subsets can suggest appropriate filtering parameters and enable selection of the optimum de novo transcriptome assembly in non-model organisms.

  19. Evaluation of effect of Ophiostoma novo-ulmi on four major wood ...

    African Journals Online (AJOL)

    Evaluation of effect of Ophiostoma novo-ulmi on four major wood species of the elm family in Rasht (North West of Iran) ... the diameter size of vessels and the number of xylary rays in four species: Ulmus carpinifolia, Ulmus glabra, Zelkova carpinifolia and Celtis australis as important factors in host resistance to elm disease.

  20. De novo formation of centrosomes in vertebrate cells arrested during S phase

    NARCIS (Netherlands)

    Khodjakov, A; Rieder, CL; Sluder, G; Cassels, G; Sibon, O; Wang, CL

    2002-01-01

    The centrosome usually replicates in a semiconservative fashion, i.e., new centrioles form in association with preexisting "maternal" centrioles. De novo formation of centrioles has been reported for a few highly specialized cell types but it has not been seen in vertebrate somatic cells. We find

  1. Robust de novo pathway enrichment with KeyPathwayMiner 5

    DEFF Research Database (Denmark)

    Alcaraz, Nicolas; List, Markus; Dissing-Hansen, Martin

    2016-01-01

    Identifying functional modules or novel active pathways, recently termed de novo pathway enrichment, is a computational systems biology challenge that has gained much attention during the last decade. Given a large biological interaction network, KeyPathwayMiner extracts connected subnetworks tha...

  2. De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder

    Science.gov (United States)

    Dong, Shan; Walker, Michael F.; Carriero, Nicholas J.; DiCola, Michael; Willsey, A. Jeremy; Ye, Adam Y.; Waqar, Zainulabedin; Gonzalez, Luis E.; Overton, John D.; Frahm, Stephanie; Keaney, John F.; Teran, Nicole A.; Dea, Jeanselle; Mandell, Jeffrey D.; Bal, Vanessa Hus; Sullivan, Catherine A.; DiLullo, Nicholas M.; Khalil, Rehab O.; Gockley, Jake; Yuksel, Zafer; Sertel, Sinem M.; Ercan-Sencicek, A. Gulhan; Gupta, Abha R.; Mane, Shrikant M.; Sheldon, Michael; Brooks, Andrew I.; Roeder, Kathryn; Devlin, Bernie; State, Matthew W.; Wei, Liping; Sanders, Stephan J.

    2014-01-01

    SUMMARY Whole-exome sequencing (WES) studies have demonstrated the contribution of de novo loss-of-function single nucleotide variants to autism spectrum disorders (ASD). However, challenges in the reliable detection of de novo insertions and deletions (indels) have limited inclusion of these variants in prior analyses. Through the application of a robust indel detection method to WES data from 787 ASD families (2,963 individuals), we demonstrate that de novo frameshift indels contribute to ASD risk (OR=1.6; 95%CI=1.0-2.7; p=0.03), are more common in female probands (p=0.02), are enriched among genes encoding FMRP targets (p=6×10−9), and arise predominantly on the paternal chromosome (p<0.001). Based on mutation rates in probands versus unaffected siblings, de novo frameshift indels contribute to risk in approximately 3.0% of individuals with ASD. Finally, through observing clustering of mutations in unrelated probands, we report two novel ASD-associated genes: KMT2E (MLL5), a chromatin regulator, and RIMS1, a regulator of synaptic vesicle release. PMID:25284784

  3. Novo Jornalismo: fronteiras litero-factuais em A sangue Frio e em Radical Chique

    Directory of Open Access Journals (Sweden)

    Francisco Aquinei Timóteo Queirós

    2012-12-01

    Full Text Available A pesquisa busca analisar de que forma fato e ficção se entrecruzam no “movimento” do Novo Jornalismo, a partir das obras A sangue Frio e Radical Chique e o Novo Jornalismo, de Truman Capote e Tom Wolfe, respectivamente. Pretende-se, a partir da investigação do corpus em estudo, revelar os aspectos que aproximam o fato jornalístico, a notícia e a reportagem às técnicas literárias do romance, do conto e da crônica. O estudo investiga o Novo Jornalismo sob o viés de textos centrais das áreas de teoria literária e estudos jornalísticos utilizando autores como Mikhail Bakhtin, Hayden White, Paul Ricoeur, Muniz Sodré; além de referenciar outros escritores que, como Tom Wolfe e Truman Capote, fizeram parte de um grande movimento renovador do jornalismo literário nos anos 1950, 1960 e 1970 chamado, genericamente, de Novo Jornalismo.

  4. CycloBranch: De Novo Sequencing of Nonribosomal Peptides from Accurate Product Ion Mass Spectra

    Czech Academy of Sciences Publication Activity Database

    Novák, Jiří; Lemr, Karel; Schug, K. A.; Havlíček, Vladimír

    2015-01-01

    Roč. 26, č. 10 (2015), s. 1780-1786 ISSN 1044-0305 R&D Projects: GA ČR(CZ) GAP206/12/1150 Grant - others:OPPC(XE) CZ.2.16/3.1.00/24023 Institutional support: RVO:61388971 Keywords : De novo sequencing * Nonribosomal peptides * Linear Subject RIV: CE - Biochemistry Impact factor: 3.031, year: 2015

  5. Novo Jornalismo: fronteiras litero-factuais em A sangue Frio e em Radical Chique

    Directory of Open Access Journals (Sweden)

    Francisco Aquinei Timóteo Queirós

    2012-03-01

    Full Text Available http://dx.doi.org/10.5007/1984-784X.2012v12n18p130 A pesquisa busca analisar de que forma fato e ficção se entrecruzam no “movimento” do Novo Jornalismo, a partir das obras A sangue Frio e Radical Chique e o Novo Jornalismo, de Truman Capote e Tom Wolfe, respectivamente. Pretende-se, a partir da investigação do corpus em estudo, revelar os aspectos que aproximam o fato jornalístico, a notícia e a reportagem às técnicas literárias do romance, do conto e da crônica. O estudo investiga o Novo Jornalismo sob o viés de textos centrais das áreas de teoria literária e estudos jornalísticos utilizando autores como Mikhail Bakhtin, Hayden White, Paul Ricoeur, Muniz Sodré; além de referenciar outros escritores que, como Tom Wolfe e Truman Capote, fizeram parte de um grande movimento renovador do jornalismo literário nos anos 1950, 1960 e 1970 chamado, genericamente, de Novo Jornalismo.

  6. Predicting survival of de novo metastatic breast cancer in Asian women: systematic review and validation study.

    Science.gov (United States)

    Miao, Hui; Hartman, Mikael; Bhoo-Pathy, Nirmala; Lee, Soo-Chin; Taib, Nur Aishah; Tan, Ern-Yu; Chan, Patrick; Moons, Karel G M; Wong, Hoong-Seam; Goh, Jeremy; Rahim, Siti Mastura; Yip, Cheng-Har; Verkooijen, Helena M

    2014-01-01

    In Asia, up to 25% of breast cancer patients present with distant metastases at diagnosis. Given the heterogeneous survival probabilities of de novo metastatic breast cancer, individual outcome prediction is challenging. The aim of the study is to identify existing prognostic models for patients with de novo metastatic breast cancer and validate them in Asia. We performed a systematic review to identify prediction models for metastatic breast cancer. Models were validated in 642 women with de novo metastatic breast cancer registered between 2000 and 2010 in the Singapore Malaysia Hospital Based Breast Cancer Registry. Survival curves for low, intermediate and high-risk groups according to each prognostic score were compared by log-rank test and discrimination of the models was assessed by concordance statistic (C-statistic). We identified 16 prediction models, seven of which were for patients with brain metastases only. Performance status, estrogen receptor status, metastatic site(s) and disease-free interval were the most common predictors. We were able to validate nine prediction models. The capacity of the models to discriminate between poor and good survivors varied from poor to fair with C-statistics ranging from 0.50 (95% CI, 0.48-0.53) to 0.63 (95% CI, 0.60-0.66). The discriminatory performance of existing prediction models for de novo metastatic breast cancer in Asia is modest. Development of an Asian-specific prediction model is needed to improve prognostication and guide decision making.

  7. De novo nonsense mutations in ASXL1 cause Bohring-Opitz syndrome

    NARCIS (Netherlands)

    Hoischen, Alexander; van Bon, Bregje W. M.; Rodríguez-Santiago, Benjamín; Gilissen, Christian; Vissers, Lisenka E. L. M.; de Vries, Petra; Janssen, Irene; van Lier, Bart; Hastings, Rob; Smithson, Sarah F.; Newbury-Ecob, Ruth; Kjaergaard, Susanne; Goodship, Judith; McGowan, Ruth; Bartholdi, Deborah; Rauch, Anita; Peippo, Maarit; Cobben, Jan M.; Wieczorek, Dagmar; Gillessen-Kaesbach, Gabriele; Veltman, Joris A.; Brunner, Han G.; de Vries, Bert B. B. A.

    2011-01-01

    Bohring-Opitz syndrome is characterized by severe intellectual disability, distinctive facial features and multiple congenital malformations. We sequenced the exomes of three individuals with Bohring-Opitz syndrome and in each identified heterozygous de novo nonsense mutations in ASXL1, which is

  8. De novo mutations of KIAA2022 in females cause intellectual disability and intractable epilepsy

    DEFF Research Database (Denmark)

    de Lange, Iris M; Helbig, Katherine L; Weckhuysen, Sarah

    2016-01-01

    BACKGROUND: Mutations in the KIAA2022 gene have been reported in male patients with X-linked intellectual disability, and related female carriers were unaffected. Here, we report 14 female patients who carry a heterozygous de novo KIAA2022 mutation and share a phenotype characterised by intellect...

  9. Wound complications and surgical events in de novo heart transplant patients treated with everolimus

    DEFF Research Database (Denmark)

    Rashidi, Mitra; Esmaily, Sorosh; Fiane, Arnt E

    2016-01-01

    OBJECTIVES: The use of mammalian target of rapamycin (mTOR) inhibitors have been limited by adverse events (AE), including delayed wound healing. We retrospectively reviewed all AE and serious AE (SAE) in The Scandinavian heart transplant (HTx) everolimus (EVE) de novo trial with early calcineurin...

  10. Associations between Familial Rates of Psychiatric Disorders and De Novo Genetic Mutations in Autism

    Directory of Open Access Journals (Sweden)

    Kyleen Luhrs

    2017-01-01

    Full Text Available The purpose of this study was to examine the confluence of genetic and familial risk factors in children with Autism Spectrum Disorder (ASD with distinct de novo genetic events. We hypothesized that gene-disrupting mutations would be associated with reduced rates of familial psychiatric disorders relative to structural mutations. Participants included families of children with ASD in four groups: de novo duplication copy number variations (DUP, n=62, de novo deletion copy number variations (DEL, n=74, de novo likely gene-disrupting mutations (LGDM, n=267, and children without a known genetic etiology (NON, n=2111. Familial rates of psychiatric disorders were calculated from semistructured interviews. Results indicated overall increased rates of psychiatric disorders in DUP families compared to DEL and LGDM families, specific to paternal psychiatric histories, and particularly evident for depressive disorders. Higher rates of depressive disorders in maternal psychiatric histories were observed overall compared to paternal histories and higher rates of anxiety disorders were observed in paternal histories for LGDM families compared to DUP families. These findings support the notion of an additive contribution of genetic etiology and familial factors are associated with ASD risk and highlight critical need for continued work targeting these relationships.

  11. A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy

    DEFF Research Database (Denmark)

    Muona, M.; Berkovic, S. F.; Dibbens, L. M.

    2015-01-01

    Progressive myoclonus epilepsies (PMEs) are a group of rare, inherited disorders manifesting with action myoclonus, tonicclonic seizures and ataxia. We sequenced the exomes of 84 unrelated individuals with PME of unknown cause and molecularly solved 26 cases (31%). Remarkably, a recurrent de novo...

  12. A Política Econômica Regional do Vale do São Francisco: Uma Busca do Desenvolvimento do Interior Brasileiro

    Directory of Open Access Journals (Sweden)

    José Vieira Camelo Filho-Zuza

    2011-06-01

    Full Text Available O rio São Francisco é um marco econômico do interior do Brasil desde o século XVI, com o desenvolvimento da pecuária no seu Vale e este trabalho procura contribuir com a discussão a respeito da política econômica regional aplicada nesta parte do país. A água é a principal riqueza do rio e do seu Vale e foco das atividades econômicas no decorrer de 6 décadas, cuja política de desenvolvimento regional é a mais antiga do País, iniciada com a criação da empresa estatal Companhia Hidrelétrica do São Francisco -CHESF, em 1945. No ano seguinte, a nova Constituição do País estabeleceu que 1% do orçamento da União deveria ser destinado ao desenvolvimento do Vale do Francisco durante 20 anos. Em 1948, o Governo Central criou a Comissão do Vale do São Francisco - CVSF para realizar a infra-estrutura do Vale, mas foi substituída pela Superintendência do Vale do São Francisco - SUVALE, em 1967. A partir de 1974, a SUVALE deu lugar a Companhia de Desenvolvimento do Vale do São Francisco - CODEVASF, empresa responsável pelo desenvolvimento do Vale. Paralelamente esta região vem recebendo uma série investimentos públicos e privados como a implantação da Universidade Federal do Vale do São Francisco- UNIVASF em 2003. O início das obras de transferência de água do São Francisco para outras bacias hidrográficas e da E.F. Transnordestina, ambas em 2007.

  13. Acculturation, Dietary Practices and Risk for Childhood Obesity in an Ethnically Heterogeneous Population of Latino School Children in the San Francisco Bay Area

    OpenAIRE

    Wojcicki, Janet M.; Schwartz, Norah; Jiménez-Cruz, Arturo; Bacardi-Gascon, Montserrat; Heyman, Melvin B.

    2012-01-01

    Previous studies have found increased acculturation to the US lifestyle increases risk for obesity in Latinos. However, methodologies differ, and results in children are inconsistent. Moreover, previous studies have not evaluated risk factors within the heterogeneous US population. We recruited 144 self-identified Latino school children and their mother or father in grades 4–6 in San Francisco parochial schools and South San Francisco public schools using an information letter distributed to ...

  14. O EFEITO DO TRICLOSAN NO PROCESSO FIBROSANTE DE CÉLULAS HEPÁTICAS LX-2 MEDIANTE A AÇÃO NA SÍNTESE DE ÁCIDO GRAXO DE NOVO

    Directory of Open Access Journals (Sweden)

    Juliana Fabiani Miranda

    2017-02-01

    Full Text Available A fibrose hepática é uma condição clínica presente na maioria das doenças hepáticas, caracterizada pelo aumento na síntese dos componentes da matriz extracelular na tentativa de cicatrização do tecido lesionado. A principal célula responsável pelo desenvolvimento da fibrose hepática é a célula estrelada hepática, localizada no espaço de Disse. Esta apresenta dois fenótipos: o quiescente e o ativado. O metabolismo de lipídeo na célula estrelada está relacionado com o fornecimento de energia para a iniciação e perpetuação do seu estado ativado. Dentro deste contexto a ácido graxo sintase (FASN, proteína chave da síntese de ácido graxo de novo torna-se alvo do estudo, uma vez que o metabolismo de lipídeos está intimamente relacionado ao processo fibrosante em células estreladas hepáticas. Sabe-se que o fármaco triclosan (TCS é inibidor da proteína FASN na síntese de ácido graxo de novo, com potencial alteração do processo fibrosante em células estreladas hepáticas. Sendo assim, avaliamos os aspectos celulares e moleculares do efeito do fármaco TCS na modulação do metabolismo de lipídeo através da inibição da FASN em modelo de células estreladas hepáticas LX-2. Os resultados demonstraram que o TCS na concentração 50 µM em cultura celular LX-2 crescida em 10% de soro bovino fetal (SBF – estado ativado- promove alterações morfofuncionais nas células; tanto pela despolimerização dos filamentos de actina quanto pela formação de estruturas globulares de actina no citoesqueleto celular. Desta maneira, o fármaco TCS apresentou características possivelmente citotóxicas em células LX-2 com 10% de SBF. Por outro lado, o estudo da inibição da proteína FASN demonstrou resultados que sugerem uma transdiferenciação celular correlacionada com a reversão do quadro pró-fibrosante hepático em células LX-2, com o aumento das gotículas de lipídeo no citoplasma e aumento da expressão dos

  15. The impact of employee satisfaction on productivity in Tiskarna Novo mesto, Ltd.

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    Simona Cimperman

    2016-06-01

    Full Text Available Research Question: Does employee satisfaction, impact on productivity? How are these two variables associated? What is the job satisfaction in Tiskarna Novo mesto, Ltd. What needs to be done to make employees more satisfied at work and, consequently, more productive? Purpose: The purpose of the study is to determine what are the factors that influence employee satisfaction Tiskarna Novo mesto, Ltd. and check the connection between work satisfaction and employee productivity. The aim of the research is to examine what is the level of job satisfaction of employees in Tiskarna Novo mesto, Ltd. And find our reasons and factors that prevent employees were satisfied in the workplace. Method: In this study we used a descriptive method and the method of combining the study of domestic and foreign literature. Pending the results we have come to interview employees in the Tiskarna Novo mesto, Ltd. Results: We conducted a survey among employees in Tiskarna Novo mesto, Ltd and we came to the conclusion that the employees are medium satisfied – the average grade point job satisfaction of employees was 3.1 (evaluated on a 5-point Likert scale. The worst assessed was factor in job satisfaction opportunity for advancement and educational opportunities. We have found out that factors like receiving praise and awards as well as good interpersonal relations are those that affect good on job satisfaction, on the other hand conflict is the one that reduces job satisfaction. The existence of links between work satisfaction and productivity were not found (r = -0.061. Organization: The organization and managers, it is important to know which are the factors by which employees are satisfied or dissatisfied. Results of the research will give managers a clear picture of the factors of satisfaction / dissatisfaction and opinion on productivity. Society: The employees it means a lot to have your job satisfaction and consequently they are more productive. Originality: The

  16. TRANSPORT OF PATIENTS FOR PRIMARY PTCA FROM GENERAL HOSPITAL NOVO MESTO TO LJUBLJANA IN 2002

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    Renata Okrajšek

    2004-12-01

    Full Text Available Background. The treatment of acute coronary syndrome (ACS with ST-segment elevation with primary percutaneous transluminal coronary angioplasty (PTCA is the best way to treat these patients. Primary PTCA is also practicable with patients who are admitted into institution without catheter laboratory. The transport of patients into the tertiary institution is safe, but it is important to keep the time of ischemia as short as possible and to reach the time interval of door-balloon as recommended by the guidelines. The ACS patients with ST-segment elevation that were directed into General Hospital Novo mesto after examination at the internistic emergency department have been redirected to KC Ljubljana for realization of PTCA since October 2001.Methods. A prospective analysis of patients with ACS with STsegment elevation, who had been transferred from General Hospital Novo mesto to KC Ljubljana in the period from January 1, 2002 to December 31, 2002 to have a primary PTCA, was performed. The analysis comprised the following: the time interval of handling the patients at Internistic department of General Hospital Novo mesto, the time of transport of patients to Ljubljana and total time interval from the arrival of patients to General Hospital Novo mesto to the first inflation of balloon in Ljubljana. We monitored the complications that occurred during the treatment of the patients.Results. In the above mentioned period 29 patients (24 males and 5 females were transported from the General Hospital Novo mesto to the KC Ljubljana to have a primary PTCA performed. The total time interval measured between the patients’ arrival to General Hospital Novo mesto to the first inflation of balloon in Ljubljana in the year 2002 was 145 minutes, which is 17 minutes better than in the previous period. The time interval recommended by the guidelines was achieved with four patients.Conclusions. By recognizing the problems that had encountered with directing the

  17. Distribution and demography of San Francisco gartersnakes (Thamnophis sirtalis tetrataenia) at Mindego Ranch, Russian Ridge Open Space Preserve, San Mateo County, California

    Science.gov (United States)

    Kim, Richard; Halstead, Brian J.; Wylie, Glenn D.; Casazza, Michael L.

    2018-04-26

    San Francisco gartersnakes (Thamnophis sirtalis tetrataenia) are a subspecies of common gartersnakes endemic to the San Francisco Peninsula of northern California. Because of habitat loss and collection for the pet trade, San Francisco gartersnakes were listed as endangered under the precursor to the Federal Endangered Species Act. A population of San Francisco gartersnakes resides at Mindego Ranch, San Mateo County, which is part of the Russian Ridge Open Space Preserve owned and managed by the Midpeninsula Regional Open Space District (MROSD). Because the site contained non-native fishes and American bullfrogs (Lithobates catesbeianus), MROSD implemented management to eliminate or reduce the abundance of these non-native species in 2014. We monitored the population using capture-mark-recapture techniques to document changes in the population during and following management actions. Although drought confounded some aspects of inference about the effects of management, prey and San Francisco gartersnake populations generally increased following draining of Aquatic Feature 3. Continued management of the site to keep invasive aquatic predators from recolonizing or increasing in abundance, as well as vegetation management that promotes heterogeneous grassland/shrubland near wetlands, likely would benefit this population of San Francisco gartersnakes.

  18. Tras ser desfigurado, Francisco de Rojas Zorrilla entra en el parnaso español. Los siglos XVIII y XIX

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    Álvarez Barrientos, Joaquín

    2007-06-01

    Full Text Available The article studies the presence of the theater of Francisco de Rojas in the Spanish scenes of centuries XVIII and XIX, as well as the way in which the critical and historians of Literature valued that author. The refundiciones of their works, their relation with Fernandez de Moratín and their entrance in the national Parnaso are detailed.El artículo estudia la presencia del teatro de Francisco de Rojas en los escenarios españoles de los siglos XVIII y XIX, así como el modo en que los críticos e historiadores de la literatura valoraron a ese autor. Se detallan las refundiciones de sus obras, su relación con Fernández de Moratín y su entrada en el Parnaso nacional.

  19. Mercury in birds of San Francisco Bay-Delta, California: trophic pathways, bioaccumulation, and ecotoxicological risk to avian reproduction

    Science.gov (United States)

    Ackerman, Joshua T.; Eagles-Smith, Collin A.; Heinz, Gary; De La Cruz, Susan E. W.; Takekawa, John Y.; Miles, A. Keith; Adelsbach, Terrence L.; Herzog, Mark P.; Bluso-Demers, Jill D.; Demers, Scott A.; Herring, Garth; Hoffman, David J.; Hartman, Christopher A.; Willacker, James J.; Suchanek, Thomas H.; Schwarzbach, Steven E.; Maurer, Thomas C.

    2014-01-01

    San Francisco Bay Estuary in northern California has a legacy of mercury contamination, which could reduce the health and reproductive success of waterbirds in the estuary. The goal of this study was to use an integrated field and laboratory approach to evaluate the risks of mercury exposure to birds in the estuary. We examined mercury bioaccumulation, and other contaminants of concern, in five waterbird species that depend heavily on San Francisco Bay Estuary for foraging and breeding habitat: American avocets (Recurvirostra americana), black-necked stilts (Himantopus mexicanus), Forster’s terns (Sterna forsteri), Caspian terns (Hydroprogne caspia), and surf scoters (Melanitta perspicillata). These species have different foraging habitats and diets that represent three distinct foraging guilds within the estuary’s food web. In this report, we provide an integrated synthesis of the primary findings from this study and results are synthesized from 54 peer-reviewed publications generated to date with other unpublished results.

  20. Shifting shoals and shattered rocks : How man has transformed the floor of west-central San Francisco Bay

    Science.gov (United States)

    Chin, John L.; Wong, Florence L.; Carlson, Paul R.

    2004-01-01

    San Francisco Bay, one of the world's finest natural harbors and a major center for maritime trade, is referred to as the 'Gateway to the Pacific Rim.' The bay is an urbanized estuary that is considered by many to be the major estuary in the United States most modified by man's activities. The population around the estuary has grown rapidly since the 1850's and now exceeds 7 million people. The San Francisco Bay area's economy ranks as one of the largest in the world, larger even than that of many countries. More than 10 million tourists are estimated to visit the bay region each year. The bay area's population and associated development have increasingly changed the estuary and its environment. San Francisco Bay and the contiguous Sacramento-San Joaquin Delta encompass roughly 1,600 square miles (4,100 km2) and are the outlet of a major watershed that drains more than 40 percent of the land area of the State of California. This watershed provides drinking water for 20 million people (two thirds of the State's population) and irrigates 4.5 million acres of farmland and ranchland. During the past several decades, much has been done to clean up the environment and waters of San Francisco Bay. Conservationist groups have even bought many areas on the margins of the bay with the intention of restoring them to a condition more like the natural marshes they once were. However, many of the major manmade changes to the bay's environment occurred so long ago that the nature of them has been forgotten. In addition, many changes continue to occur today, such as the introduction of exotic species and the loss of commercial and sport fisheries because of declining fish populations. The economy and population of the nine counties that surround the bay continue to grow and put increasing pressure on the bay, both direct and indirect. Therefore, there are mixed signals for the future health and welfare of San Francisco Bay. The San Francisco Bay estuary consists of three

  1. Part I, Introduction: Ecology and Regional Context of Tidal Wetlands in the San Francisco Bay National Estuarine Research Reserve

    Directory of Open Access Journals (Sweden)

    Matthew C. Ferner

    2011-12-01

    Full Text Available This two-part special issue reviews the basic ecology of tidal wetlands in the San Francisco Estuary. Several articles highlight the well-preserved tracts of historic tidal marsh found at China Camp State Park and Rush Ranch Open Space Preserve. These two protected areas serve as important reference sites for wetland restoration and conservation and also comprise San Francisco Bay National Estuarine Research Reserve (SF Bay NERR. SF Bay NERR is part of the National Oceanic and Atmospheric Administration’s nationwide network of 28 estuarine research reserves (http://www.nerrs.noaa.gov that all share common goals: (1 conducting standardized long-term monitoring, (2 supporting applied environmental research, (3 providing stewardship of estuarine natural resources, and (4 linking science with decision making in pursuit of effective solutions to coastal management problems.

  2. Crisis of the social and emergence of sociality in the new scenarios of identity. The San Francisco district of Bilbao

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    Beatriz Cavia

    2008-09-01

    Full Text Available The San Francisco district in Bilbao (Spain is undergoing a deep process of urban transformation in which there is a convergence of different dynamics —economic (property speculation, social (appearance of associations and social movements and political (rehabilitation plans. In order to explain this transformation, we test two hypotheses in the article: gentrification and the crisis of the social institutions (politics, religion and work that traditionally articulated society. To counterbalance the shortcomings of the two hypotheses we redefine them as mere “conditions of possibility” of the emergence of new forms of sociality, the depoliticisation of signifieds and the production of new spaces. San Francisco constitutes a variable cronotope that provokes a blurring in sociological configurations and in social norms and sanctions.

  3. Promoting Health and Safety in San Francisco's Chinatown Restaurants: Findings and Lessons Learned from a Pilot Observational Checklist

    Science.gov (United States)

    Gaydos, Megan; Bhatia, Rajiv; Morales, Alvaro; Lee, Pam Tau; Liu, Shaw San; Chang, Charlotte; Salvatore, Alicia L.; Krause, Niklas; Minkler, Meredith

    2011-01-01

    Noncompliance with labor and occupational health and safety laws contributes to economic and health inequities. Environmental health agencies are well positioned to monitor workplace conditions in many industries and support enhanced enforcement by responsible regulatory agencies. In collaboration with university and community partners, the San Francisco Department of Public Health used an observational checklist to assess preventable occupational injury hazards and compliance with employee notification requirements in 106 restaurants in San Francisco's Chinatown. Sixty-five percent of restaurants had not posted required minimum wage, paid sick leave, or workers' compensation notifications; 82% of restaurants lacked fully stocked first-aid kits; 52% lacked antislip mats; 37% lacked adequate ventilation; and 28% lacked adequate lighting. Supported by a larger community-based participatory research process, this pilot project helped to spur additional innovative health department collaborations to promote healthier workplaces. PMID:21836739

  4. Destigmatizing hepatitis B in the Asian American community: lessons learned from the San Francisco Hep B Free Campaign.

    Science.gov (United States)

    Yoo, Grace J; Fang, Ted; Zola, Janet; Dariotis, Wei Ming

    2012-03-01

    Compared to any other racial/ethnic group, Asian Americans represent a population disproportionately affected by hepatitis B virus (HBV) infection, a leading cause of liver cancer. Since 2007, the San Francisco Hep B Free (SFHBF) Campaign has been actively creating awareness and education on the importance of screening, testing, and vaccination of HBV among Asian Americans. In order to understand what messages resonated with Asian Americans in San Francisco, key informant interviews with 23 (n = 23) individuals involved in community outreach were conducted. A key finding was the ability of the SFHBF campaign to utilize unique health communication strategies to break the silence and normalize discussions of HBV. In addition, the campaign's approach to using public disclosures and motivating action by emphasizing solutions towards ending HBV proved to resonate with Asian Americans. The findings and lessons learned have implications for not only HBV but other stigmatized health issues in the Asian American community.

  5. A prognostic scoring model for survival after locoregional therapy in de novo stage IV breast cancer.

    Science.gov (United States)

    Kommalapati, Anuhya; Tella, Sri Harsha; Goyal, Gaurav; Ganti, Apar Kishor; Krishnamurthy, Jairam; Tandra, Pavan Kumar

    2018-05-02

    The role of locoregional treatment (LRT) remains controversial in de novo stage IV breast cancer (BC). We sought to analyze the role of LRT and prognostic factors of overall survival (OS) in de novo stage IV BC patients treated with LRT utilizing the National Cancer Data Base (NCDB). The objective of the current study is to create and internally validate a prognostic scoring model to predict the long-term OS for de novo stage IV BC patients treated with LRT. We included de novo stage IV BC patients reported to NCDB between 2004 and 2015. Patients were divided into LRT and no-LRT subsets. We randomized LRT subset to training and validation cohorts. In the training cohort, a seventeen-point prognostic scoring system was developed based on the hazard ratios calculated using Cox-proportional method. We stratified both training and validation cohorts into two "groups" [group 1 (0-7 points) and group 2 (7-17 points)]. Kaplan-Meier method and log-rank test were used to compare OS between the two groups. Our prognostic score was validated internally by comparing the OS between the respective groups in both the training and validation cohorts. Among 67,978 patients, LRT subset (21,200) had better median OS as compared to that of no-LRT (45 vs. 24 months; p < 0.0001). The group 1 and group 2 in the training cohort showed a significant difference in the 3-year OS (p < 0.0001) (68 vs. 26%). On internal validation, comparable OS was seen between the respective groups in each cohort (p = 0.77). Our prognostic scoring system will help oncologists to predict the prognosis in de novo stage IV BC patients treated with LRT. Although firm treatment-related conclusions cannot be made due to the retrospective nature of the study, LRT appears to be associated with a better OS in specific subgroups.

  6. De Novo Heart Failure After Kidney Transplantation: Trends in Incidence and Outcomes.

    Science.gov (United States)

    Lenihan, Colin R; Liu, Sai; Deswal, Anita; Montez-Rath, Maria E; Winkelmayer, Wolfgang C

    2018-03-29

    Heart failure is an important cause of morbidity and mortality following kidney transplantation. Some studies in the general population have shown that the incidence of heart failure has decreased during the past 20 years. However, it is not currently known whether such a trend exists in the kidney transplantation population. Retrospective observational cohort study. Adult patients included in the US Renal Data System who underwent their first kidney transplantation in the United States between 1998 and 2010 with at least 6 months of continuous Medicare parts A and B coverage before transplantation and no prior evidence for a diagnosis of heart failure before kidney transplantation. Calendar year of transplantation and calendar year of posttransplantation heart failure diagnosis. De novo posttransplantation heart failure defined using International Classification of Diseases, Ninth Revision diagnosis codes and mortality following de novo posttransplantation heart failure diagnosis. Secular trends in de novo post-kidney transplantation heart failure were examined using Cox proportional hazards analysis. Within a study cohort of 48,771 patients, 7,269 developed de novo heart failure within 3 years of kidney transplantation, with a median time to heart failure of 0.76 years. The adjusted HR for heart failure with death as competing risk comparing patients who underwent transplantation in 2010 with those who underwent transplantation in 1998 was 0.69 (95% CI, 0.60-0.79). No temporal trend in mortality following a diagnosis of post-kidney transplantation heart failure was observed. Potential residual confounding from either incorrectly ascertained or unavailable confounders. The cohort was limited to Medicare beneficiaries. Adjusted for demographic and clinical characteristics, the risk for developing de novo post-kidney transplantation heart failure has declined significantly between 1998 and 2010, with no apparent change in subsequent mortality. Copyright © 2018

  7. Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs.

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    Chen Xie

    2012-09-01

    Full Text Available Tinkering with pre-existing genes has long been known as a major way to create new genes. Recently, however, motherless protein-coding genes have been found to have emerged de novo from ancestral non-coding DNAs. How these genes originated is not well addressed to date. Here we identified 24 hominoid-specific de novo protein-coding genes with precise origination timing in vertebrate phylogeny. Strand-specific RNA-Seq analyses were performed in five rhesus macaque tissues (liver, prefrontal cortex, skeletal muscle, adipose, and testis, which were then integrated with public transcriptome data from human, chimpanzee, and rhesus macaque. On the basis of comparing the RNA expression profiles in the three species, we found that most of the hominoid-specific de novo protein-coding genes encoded polyadenylated non-coding RNAs in rhesus macaque or chimpanzee with a similar transcript structure and correlated tissue expression profile. According to the rule of parsimony, the majority of these hominoid-specific de novo protein-coding genes appear to have acquired a regulated transcript structure and expression profile before acquiring coding potential. Interestingly, although the expression profile was largely correlated, the coding genes in human often showed higher transcriptional abundance than their non-coding counterparts in rhesus macaque. The major findings we report in this manuscript are robust and insensitive to the parameters used in the identification and analysis of de novo genes. Our results suggest that at least a portion of long non-coding RNAs, especially those with active and regulated transcription, may serve as a birth pool for protein-coding genes, which are then further optimized at the transcriptional level.

  8. De Novo Insertions and Deletions of Predominantly Paternal Origin Are Associated with Autism Spectrum Disorder

    Directory of Open Access Journals (Sweden)

    Shan Dong

    2014-10-01

    Full Text Available Summary: Whole-exome sequencing (WES studies have demonstrated the contribution of de novo loss-of-function single-nucleotide variants (SNVs to autism spectrum disorder (ASD. However, challenges in the reliable detection of de novo insertions and deletions (indels have limited inclusion of these variants in prior analyses. By applying a robust indel detection method to WES data from 787 ASD families (2,963 individuals, we demonstrate that de novo frameshift indels contribute to ASD risk (OR = 1.6; 95% CI = 1.0–2.7; p = 0.03, are more common in female probands (p = 0.02, are enriched among genes encoding FMRP targets (p = 6 × 10−9, and arise predominantly on the paternal chromosome (p < 0.001. On the basis of mutation rates in probands versus unaffected siblings, we conclude that de novo frameshift indels contribute to risk in approximately 3% of individuals with ASD. Finally, by observing clustering of mutations in unrelated probands, we uncover two ASD-associated genes: KMT2E (MLL5, a chromatin regulator, and RIMS1, a regulator of synaptic vesicle release. : Insertions and deletions (indels have proven especially difficult to detect in exome sequencing data. Dong et al. now identify indels in exome data for 787 autism spectrum disorder (ASD families. They demonstrate association between de novo indels that alter the reading frame and ASD. Furthermore, by observing clustering of indels in unrelated probands, they uncover two additional ASD-associated genes: KMT2E (MLL5, a chromatin regulator, and RIMS1, a regulator of synaptic vesicle release.

  9. De novo synthesis of adenine nucleotides in different skeletal muscle fiber types

    International Nuclear Information System (INIS)

    Tullson, P.C.; John-Alder, H.B.; Hood, D.A.; Terjung, R.L.

    1988-01-01

    Management of adenine nucleotide catabolism differs among skeletal muscle fiber types. This study evaluated whether there are corresponding differences in the rates of de novo synthesis of adenine nucleotide among fiber type sections of skeletal muscle using an isolated perfused rat hindquarter preparation. Label incorporation into adenine nucleotides from the [1-14C]glycine precursor was determined and used to calculate synthesis rates based on the intracellular glycine specific radioactivity. Results show that intracellular glycine is closely related to the direct precursor pool. Rates of de novo synthesis were highest in fast-twitch red muscle (57.0 +/- 4.0, 58.2 +/- 4.4 nmol.h-1.g-1; deep red gastrocnemius and vastus lateralis), relatively high in slow-twitch red muscle (47.0 +/- 3.1; soleus), and low in fast-twitch white muscle (26.1 +/- 2.0 and 21.6 +/- 2.3; superficial white gastrocnemius and vastus lateralis). Rates for four mixed muscles were intermediate, ranging between 32.3 and 37.3. Specific de novo synthesis rates exhibited a strong correlation (r = 0.986) with muscle section citrate synthase activity. Turnover rates (de novo synthesis rate/adenine nucleotide pool size) were highest in high oxidative muscle (0.82-1.06%/h), lowest in low oxidative muscle (0.30-0.35%/h), and intermediate in mixed muscle (0.44-0.55%/h). Our results demonstrate that differences in adenine nucleotide management among fiber types extends to the process of de novo adenine nucleotide synthesis

  10. Efficient assembly of de novo human artificial chromosomes from large genomic loci

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    Stromberg Gregory

    2005-07-01

    Full Text Available Abstract Background Human Artificial Chromosomes (HACs are potentially useful vectors for gene transfer studies and for functional annotation of the genome because of their suitability for cloning, manipulating and transferring large segments of the genome. However, development of HACs for the transfer of large genomic loci into mammalian cells has been limited by difficulties in manipulating high-molecular weight DNA, as well as by the low overall frequencies of de novo HAC formation. Indeed, to date, only a small number of large (>100 kb genomic loci have been reported to be successfully packaged into de novo HACs. Results We have developed novel methodologies to enable efficient assembly of HAC vectors containing any genomic locus of interest. We report here the creation of a novel, bimolecular system based on bacterial artificial chromosomes (BACs for the construction of HACs incorporating any defined genomic region. We have utilized this vector system to rapidly design, construct and validate multiple de novo HACs containing large (100–200 kb genomic loci including therapeutically significant genes for human growth hormone (HGH, polycystic kidney disease (PKD1 and ß-globin. We report significant differences in the ability of different genomic loci to support de novo HAC formation, suggesting possible effects of cis-acting genomic elements. Finally, as a proof of principle, we have observed sustained ß-globin gene expression from HACs incorporating the entire 200 kb ß-globin genomic locus for over 90 days in the absence of selection. Conclusion Taken together, these results are significant for the development of HAC vector technology, as they enable high-throughput assembly and functional validation of HACs containing any large genomic locus. We have evaluated the impact of different genomic loci on the frequency of HAC formation and identified segments of genomic DNA that appear to facilitate de novo HAC formation. These genomic loci

  11. De novo triiodothyronine formation from thyrocytes activated by thyroid-stimulating hormone.

    Science.gov (United States)

    Citterio, Cintia E; Veluswamy, Balaji; Morgan, Sarah J; Galton, Valerie A; Banga, J Paul; Atkins, Stephen; Morishita, Yoshiaki; Neumann, Susanne; Latif, Rauf; Gershengorn, Marvin C; Smith, Terry J; Arvan, Peter

    2017-09-15

    The thyroid gland secretes primarily tetraiodothyronine (T 4 ), and some triiodothyronine (T 3 ). Under normal physiological circumstances, only one-fifth of circulating T 3 is directly released by the thyroid, but in states of hyperactivation of thyroid-stimulating hormone receptors (TSHRs), patients develop a syndrome of relative T 3 toxicosis. Thyroidal T 4 production results from iodination of thyroglobulin (TG) at residues Tyr 5 and Tyr 130 , whereas thyroidal T 3 production may originate in several different ways. In this study, the data demonstrate that within the carboxyl-terminal portion of mouse TG, T 3 is formed de novo independently of deiodination from T 4 We found that upon iodination in vitro , de novo T 3 formation in TG was decreased in mice lacking TSHRs. Conversely, de novo T 3 that can be formed upon iodination of TG secreted from PCCL3 (rat thyrocyte) cells was augmented from cells previously exposed to increased TSH, a TSHR agonist, a cAMP analog, or a TSHR-stimulating antibody. We present data suggesting that TSH-stimulated TG phosphorylation contributes to enhanced de novo T 3 formation. These effects were reversed within a few days after removal of the hyperstimulating conditions. Indeed, direct exposure of PCCL3 cells to human serum from two patients with Graves' disease, but not control sera, led to secretion of TG with an increased intrinsic ability to form T 3 upon in vitro iodination. Furthermore, TG secreted from human thyrocyte cultures hyperstimulated with TSH also showed an increased intrinsic ability to form T 3 Our data support the hypothesis that TG processing in the secretory pathway of TSHR-hyperstimulated thyrocytes alters the structure of the iodination substrate in a way that enhances de novo T 3 formation, contributing to the relative T 3 toxicosis of Graves' disease.

  12. Automated de novo phasing and model building of coiled-coil proteins.

    Science.gov (United States)

    Rämisch, Sebastian; Lizatović, Robert; André, Ingemar

    2015-03-01

    Models generated by de novo structure prediction can be very useful starting points for molecular replacement for systems where suitable structural homologues cannot be readily identified. Protein-protein complexes and de novo-designed proteins are examples of systems that can be challenging to phase. In this study, the potential of de novo models of protein complexes for use as starting points for molecular replacement is investigated. The approach is demonstrated using homomeric coiled-coil proteins, which are excellent model systems for oligomeric systems. Despite the stereotypical fold of coiled coils, initial phase estimation can be difficult and many structures have to be solved with experimental phasing. A method was developed for automatic structure determination of homomeric coiled coils from X-ray diffraction data. In a benchmark set of 24 coiled coils, ranging from dimers to pentamers with resolutions down to 2.5 Å, 22 systems were automatically solved, 11 of which had previously been solved by experimental phasing. The generated models contained 71-103% of the residues present in the deposited structures, had the correct sequence and had free R values that deviated on average by 0.01 from those of the respective reference structures. The electron-density maps were of sufficient quality that only minor manual editing was necessary to produce final structures. The method, named CCsolve, combines methods for de novo structure prediction, initial phase estimation and automated model building into one pipeline. CCsolve is robust against errors in the initial models and can readily be modified to make use of alternative crystallographic software. The results demonstrate the feasibility of de novo phasing of protein-protein complexes, an approach that could also be employed for other small systems beyond coiled coils.

  13. Genome sequencing of bacteria: sequencing, de novo assembly and rapid analysis using open source tools.

    Science.gov (United States)

    Kisand, Veljo; Lettieri, Teresa

    2013-04-01

    De novo genome sequencing of previously uncharacterized microorganisms has the potential to open up new frontiers in microbial genomics by providing insight into both functional capabilities and biodiversity. Until recently, Roche 454 pyrosequencing was the NGS method of choice for de novo assembly because it generates hundreds of thousands of long reads (tools for processing NGS data are increasingly free and open source and are often adopted for both their high quality and role in promoting academic freedom. The error rate of pyrosequencing the Alcanivorax borkumensis genome was such that thousands of insertions and deletions were artificially introduced into the finished genome. Despite a high coverage (~30 fold), it did not allow the reference genome to be fully mapped. Reads from regions with errors had low quality, low coverage, or were missing. The main defect of the reference mapping was the introduction of artificial indels into contigs through lower than 100% consensus and distracting gene calling due to artificial stop codons. No assembler was able to perform de novo assembly comparable to reference mapping. Automated annotation tools performed similarly on reference mapped and de novo draft genomes, and annotated most CDSs in the de novo assembled draft genomes. Free and open source software (FOSS) tools for assembly and annotation of NGS data are being developed rapidly to provide accurate results with less computational effort. Usability is not high priority and these tools currently do not allow the data to be processed without manual intervention. Despite this, genome assemblers now readily assemble medium short reads into long contigs (>97-98% genome coverage). A notable gap in pyrosequencing technology is the quality of base pair calling and conflicting base pairs between single reads at the same nucleotide position. Regardless, using draft whole genomes that are not finished and remain fragmented into tens of contigs allows one to characterize

  14. The Performance of Nearshore Dredge Disposal at Ocean Beach, San Francisco, California, 2005-2007

    Science.gov (United States)

    Barnard, Patrick L.; Erikson, Li H.; Hansen, Jeff E.; Elias, Edwin

    2009-01-01

    Ocean Beach, California, contains an erosion hot spot in the shadow of the San Francisco ebb tidal delta that threatens valuable public infrastructure as well as the safe recreational use of the beach. In an effort to reduce the erosion at this location a new plan for the management of sediment dredged annually from the main shipping channel at the mouth of San Francisco Bay was implemented in May 2005 by the United States Army Corps of Engineers, San Francisco District (USACE). The USACE designated a temporary nearshore dredge disposal site for the annual disposal of about 230,000 m3 (300,000 yd3) of sand about 750 m offshore and slightly south of the erosion hot spot, in depths between approximately 9 and 14 m. The site has now been used three times for a total sediment disposal of about 690,000 m3 (about 900,000 yds3). The disposal site was chosen because it is in a location where strong tidal currents and open-ocean waves can potentially feed sediment toward the littoral zone in the reach of the beach that is experiencing critical erosion, as well as prevent further scour on an exposed outfall pipe. The onshore migration of sediment from the target disposal location might feed the primary longshore bar or the nearshore zone, and provide a buffer to erosion that peaks during winter months when large waves impact the region. The United States Geological Survey (USGS) has been monitoring and modeling the bathymetric evolution of the test dredge disposal site and the adjacent coastal region since inception in May 2005. This paper reports on the first 2.5 years of this monitoring program effort (May 2005 to December 2007) and assesses the short-term coastal response. Here are the key findings of this report: *Approximately half of the sediment that has been placed in the nearshore dredge-disposal site during the 2.5 years of this study remains within the dredge focus area. *In the winter of 2006-7, large waves transported the dredge-mound material onshore. *High

  15. Francisco de Aguiar y Seijas, pastor del rebaño

    Directory of Open Access Journals (Sweden)

    Silva Herrera, Rocío

    2014-12-01

    Full Text Available Which was the pastoral profile of Francisco de Aguiar y Seijas, archbishop of Mexico? Through the dates of the Book of visit in his fourth journey in the regions of Chalco, Amilpas, Xochimilco and Coyoacan from december 4th 1686 to april 9th 1687, and making use of the thematic biography as method, the answer to the initial question has arrived. After the Council of Trent, the bishop had the duty to promote the reform of customs in his diocese; the pastoral visit was a privileged way to achieve it. The archbishop Aguiar, educated from the tridentine discipline in the archdiocese of Santiago de Compostela, made of his pastoral visit a really popular mission among the people. He takes a small itinerant curia, to govern and discharging justice in a delegated manner. A disciplined, austere and conciliator man, he served as a souls shepherd more than a court official.¿Cuál fue el perfil pastoral de Francisco de Aguiar y Seijas, arzobispo de México? A través de los datos que aporta el Libro de visita de su cuarta salida a las regiones de Chalco, Amilpas, Xochimilco y Coyoacán del 4 de diciembre de 1686 al 9 de abril de 1687, y utilizando la metodología de la biografía temática, se ha dado respuesta a la pregunta inicial. Luego del Concilio de Trento, el obispo tenía el grave deber de suscitar la reforma de las costumbres en su diócesis; la visita pastoral fue un medio privilegiado para lograrlo. El arzobispo Aguiar, formado bajo la disciplina tridentina en la arquidiócesis compostelana, hizo de su visita pastoral una verdadera misión popular entre la gente. Acompañado de una pequeña curia itinerante, gobernó e impartió justicia con características de delegación de poder. Hombre disciplinado, austero y de carácter conciliador se dirigió más como pastor de almas que como funcionario real. [gl] Cal foi o perfil pastoral de Francisco de Aguiar e Seijas, arcebispo de México? A través dos datos que achega o libro de visita da s

  16. Sub-tidal benthic habitats of central San Francisco Bay and offshore Golden Gate area: A review

    Science.gov (United States)

    Greene, H. Gary; Endris, Charles; Vallier, Tracy; Golden, Nadine E.; Cross, Jeffery; Ryan, Holly F.; Dieter, Bryan; Niven, Eric; Barnard, P.L.; Jaffee, B.E.; Schoellhamer, D.H.

    2013-01-01

    Deep-water potential estuarine and marine benthic habitat types were defined from a variety of new and interpreted data sets in central San Francisco Bay and offshore Golden Gate area including multibeam echosounder (MBES), side-scan sonar and bottom grab samples. Potential estuarine benthic habitats identified for the first time range from hard bedrock outcrops on island and mainland flanks and some Bay floor

  17. Distribution and Genetic Structure of Fucus distichus Linnaeus 1953 (formerly F. gardneri within Central San Francisco Bay

    Directory of Open Access Journals (Sweden)

    Stephen G. Whitaker

    2017-09-01

    Full Text Available doi: https://doi.org/10.15447/sfews.2017v15iss3art4Fucus distichus, a rockweed common to the mid-intertidal shoreline within the San Francisco Estuary (previously known as F. gardneri, was injured during the Cosco Busan oil spill in November 2007 and subsequent clean-up actions. Restoration planning activities are underway to help recover F. distichus at sites within central San Francisco Bay where damage occurred. As a first step, we conducted shoreline surveys during the summers of 2012–2013 to map the occurrence of this rockweed. Of the 151.73 km of rocky shoreline within the central bay, F. distichus covered 32.16 km of shoreline. The alga generally occurred in narrow bands but formed expansive beds at locations with natural, flat bedrock benches. We also observed F. distichus on artificial substrata such as seawalls and riprap, but not on pilings. Samples of F. distichus from 11 sites throughout the central / east San Francisco Bay were genetically analyzed (microsatellite genotyping. The populations analyzed (1 had low genetic diversity, (2 the frequency of homozygotes was higher than expected (suggesting high inbreeding, and (3 also displayed geographic population structure, in part driven by very small differences in the midst of extremely low within-population genetic diversity. However, these genetic data do not raise concerns for restoration methods in terms of choosing donor populations and mixing F. distichus from different sites within the central bay. The choice of donor populations should be based on practical criteria for effective restoration; individuals will nonetheless be taken from locations as nearby to donor sites as possible. Various locations throughout the central San Francisco Bay are composed of cobble or small riprap that are populated with F. distichus, which could provide efficient means of translocating rockweed for future restoration activities.

  18. Achieving Health Equity Through Community Engagement in Translating Evidence to Policy: The San Francisco Health Improvement Partnership, 2010–2016

    Science.gov (United States)

    Vargas, Roberto A.; Fleisher, Paula; Aragón, Tomás J.; Chung, Lisa; Chawla, Colleen; Yant, Abbie; Garcia, Estela R.; Santiago, Amor; Lang, Perry L.; Jones, Paula; Liu, Wylie; Schmidt, Laura A.

    2017-01-01

    Background The San Francisco Health Improvement Partnership (SFHIP) promotes health equity by using a novel collective impact model that blends community engagement with evidence-to-policy translational science. The model involves diverse stakeholders, including ethnic-based community health equity coalitions, the local public health department, hospitals and health systems, a health sciences university, a school district, the faith community, and others sectors. Community Context We report on 3 SFHIP prevention initiatives: reducing consumption of sugar sweetened beverages (SSBs), regulating retail alcohol sales, and eliminating disparities in children’s oral health. Methods SFHIP is governed by a steering committee. Partnership working groups for each initiative collaborate to 1) develop and implement action plans emphasizing feasible, scalable, translational-science–informed interventions and 2) consider sustainability early in the planning process by including policy and structural interventions. Outcome Through SFHIP’s efforts, San Francisco enacted ordinances regulating sale and advertising of SSBs and a ballot measure establishing a soda tax. Most San Francisco hospitals implemented or committed to implementing healthy-beverage policies that prohibited serving or selling SSBs. SFHIP helped prevent Starbucks and Taco Bell from receiving alcohol licenses in San Francisco and helped prevent state authorization of sale of powdered alcohol. SFHIP increased the number of primary care clinics providing fluoride varnish at routine well-child visits from 3 to 14 and acquired a state waiver to allow dental clinics to be paid for dental services delivered in schools. Interpretation The SFHIP model of collective impact emphasizing community engagement and policy change accomplished many of its intermediate goals to create an environment promoting health and health equity. PMID:28333598

  19. Achieving Health Equity Through Community Engagement in Translating Evidence to Policy: The San Francisco Health Improvement Partnership, 2010-2016.

    Science.gov (United States)

    Grumbach, Kevin; Vargas, Roberto A; Fleisher, Paula; Aragón, Tomás J; Chung, Lisa; Chawla, Colleen; Yant, Abbie; Garcia, Estela R; Santiago, Amor; Lang, Perry L; Jones, Paula; Liu, Wylie; Schmidt, Laura A

    2017-03-23

    The San Francisco Health Improvement Partnership (SFHIP) promotes health equity by using a novel collective impact model that blends community engagement with evidence-to-policy translational science. The model involves diverse stakeholders, including ethnic-based community health equity coalitions, the local public health department, hospitals and health systems, a health sciences university, a school district, the faith community, and others sectors. We report on 3 SFHIP prevention initiatives: reducing consumption of sugar sweetened beverages (SSBs), regulating retail alcohol sales, and eliminating disparities in children's oral health. SFHIP is governed by a steering committee. Partnership working groups for each initiative collaborate to 1) develop and implement action plans emphasizing feasible, scalable, translational-science-informed interventions and 2) consider sustainability early in the planning process by including policy and structural interventions. Through SFHIP's efforts, San Francisco enacted ordinances regulating sale and advertising of SSBs and a ballot measure establishing a soda tax. Most San Francisco hospitals implemented or committed to implementing healthy-beverage policies that prohibited serving or selling SSBs. SFHIP helped prevent Starbucks and Taco Bell from receiving alcohol licenses in San Francisco and helped prevent state authorization of sale of powdered alcohol. SFHIP increased the number of primary care clinics providing fluoride varnish at routine well-child visits from 3 to 14 and acquired a state waiver to allow dental clinics to be paid for dental services delivered in schools. The SFHIP model of collective impact emphasizing community engagement and policy change accomplished many of its intermediate goals to create an environment promoting health and health equity.

  20. Ground motion modeling of the 1906 San Francisco earthquake II: Ground motion estimates for the 1906 earthquake and scenario events

    Energy Technology Data Exchange (ETDEWEB)

    Aagaard, B; Brocher, T; Dreger, D; Frankel, A; Graves, R; Harmsen, S; Hartzell, S; Larsen, S; McCandless, K; Nilsson, S; Petersson, N A; Rodgers, A; Sjogreen, B; Tkalcic, H; Zoback, M L

    2007-02-09

    We estimate the ground motions produced by the 1906 San Francisco earthquake making use of the recently developed Song et al. (2008) source model that combines the available geodetic and seismic observations and recently constructed 3D geologic and seismic velocity models. Our estimates of the ground motions for the 1906 earthquake are consistent across five ground-motion modeling groups employing different wave propagation codes and simulation domains. The simulations successfully reproduce the main features of the Boatwright and Bundock (2005) ShakeMap, but tend to over predict the intensity of shaking by 0.1-0.5 modified Mercalli intensity (MMI) units. Velocity waveforms at sites throughout the San Francisco Bay Area exhibit characteristics consistent with rupture directivity, local geologic conditions (e.g., sedimentary basins), and the large size of the event (e.g., durations of strong shaking lasting tens of seconds). We also compute ground motions for seven hypothetical scenarios rupturing the same extent of the northern San Andreas fault, considering three additional hypocenters and an additional, random distribution of slip. Rupture directivity exerts the strongest influence on the variations in shaking, although sedimentary basins do consistently contribute to the response in some locations, such as Santa Rosa, Livermore, and San Jose. These scenarios suggest that future large earthquakes on the northern San Andreas fault may subject the current San Francisco Bay urban area to stronger shaking than a repeat of the 1906 earthquake. Ruptures propagating southward towards San Francisco appear to expose more of the urban area to a given intensity level than do ruptures propagating northward.

  1. Achieving Health Equity Through Community Engagement in Translating Evidence to Policy: The San Francisco Health Improvement Partnership, 2010?2016

    OpenAIRE

    Grumbach, Kevin; Vargas, Roberto A.; Fleisher, Paula; Arag?n, Tom?s J.; Chung, Lisa; Chawla, Colleen; Yant, Abbie; Garcia, Estela R.; Santiago, Amor; Lang, Perry L.; Jones, Paula; Liu, Wylie; Schmidt, Laura A.

    2017-01-01

    Background The San Francisco Health Improvement Partnership (SFHIP) promotes health equity by using a novel collective impact model that blends community engagement with evidence-to-policy translational science. The model involves diverse stakeholders, including ethnic-based community health equity coalitions, the local public health department, hospitals and health systems, a health sciences university, a school district, the faith community, and others sectors. Community Context We report o...

  2. Real-Time GPS Monitoring for Earthquake Rapid Assessment in the San Francisco Bay Area

    Science.gov (United States)

    Guillemot, C.; Langbein, J. O.; Murray, J. R.

    2012-12-01

    The U.S. Geological Survey Earthquake Science Center has deployed a network of eight real-time Global Positioning System (GPS) stations in the San Francisco Bay area and is implementing software applications to continuously evaluate the status of the deformation within the network. Real-time monitoring of the station positions is expected to provide valuable information for rapidly estimating source parameters should a large earthquake occur in the San Francisco Bay area. Because earthquake response applications require robust data access, as a first step we have developed a suite of web-based applications which are now routinely used to monitor the network's operational status and data streaming performance. The web tools provide continuously updated displays of important telemetry parameters such as data latency and receive rates, as well as source voltage and temperature information within each instrument enclosure. Automated software on the backend uses the streaming performance data to mitigate the impact of outages, radio interference and bandwidth congestion on deformation monitoring operations. A separate set of software applications manages the recovery of lost data due to faulty communication links. Displacement estimates are computed in real-time for various combinations of USGS, Plate Boundary Observatory (PBO) and Bay Area Regional Deformation (BARD) network stations. We are currently comparing results from two software packages (one commercial and one open-source) used to process 1-Hz data on the fly and produce estimates of differential positions. The continuous monitoring of telemetry makes it possible to tune the network to minimize the impact of transient interruptions of the data flow, from one or more stations, on the estimated positions. Ongoing work is focused on using data streaming performance history to optimize the quality of the position, reduce drift and outliers by switching to the best set of stations within the network, and

  3. Review of wastewater problems and wastewater-management planning in the San Francisco Bay region, California

    Science.gov (United States)

    Hines, Walter G.

    1973-01-01

    The San Francisco Bay region has suffered adverse environmental effects related to the discharge of municipal-, industrial-, and agricultural- wastewater and storm-water runoff. Specific pollutional properties of theses discharges are not well understood in all cases although the toxic materials and aquatic-plant nutrients (biostimulants) found in municipal and industrial waterwater are considered to be a major cause of regional water-quality problems. Other water-quality problems in the region are commonly attributed to pesticides found in agricultural wastewater and potentially pathogenic bacteria in municipal-wastewater discharges and in storm-water runoff. The geographical distribution and magnitude of wastewater discharges in the bay region, particularly those from municipalities and industries, is largely a function of population, economic growth, and urban development. As might be expected, the total volume of wastewater has increased in a trend paralleling this growth and development. More significant, perhaps, is the fact that the total volume parameters such as BOD (biochemical oxygen demand), biostimulant concentrations, and toxicity, has increased despite large expenditures on new and improved municipal- and industrial-wastewater-treatment plants. Also, pollutant loadings from other major source, such as agriculture and storm-water runoff, have increased. At the time of writing (1972), many Federal, State, regional, and local agencies are engaged in a comprehensive wastewater-management-planning effort for the entire bay region. Initial objectives of this planning effort are: (1) the consolidation and coordination of loosely integrated wastewater-management facilities and (2) the elimination of wastewater discharges to ecologically sensitive areas, such as fresh-water streams and shallow extremities of San Francisco Bay. There has been some investigation of potential long-range wastewater-management alternatives based upon disposal in deep water in the

  4. Understanding Urban Watersheds through Digital Interactive Maps, San Francisco Bay Area, California

    Science.gov (United States)

    Sowers, J. M.; Ticci, M. G.; Mulvey, P.

    2014-12-01

    Dense urbanization has resulted in the "disappearance" of many local creeks in urbanized areas surrounding the San Francisco Bay. Long reaches of creeks now flow in underground pipes. Municipalities and water agencies trying to reduce non-point-source pollution are faced with a public that cannot see and therefore does not understand the interconnected nature of the drainage system or its ultimate discharge to the bay. Since 1993, we have collaborated with the Oakland Museum, the San Francisco Estuary Institute, public agencies, and municipalities to create creek and watershed maps to address the need for public understanding of watershed concepts. Fifteen paper maps are now published (www.museumca.org/creeks), which have become a standard reference for educators and anyone working on local creek-related issues. We now present digital interactive creek and watershed maps in Google Earth. Four maps are completed covering urbanized areas of Santa Clara and Alameda Counties. The maps provide a 3D visualization of the watersheds, with cartography draped over the landscape in transparent colors. Each mapped area includes both Present and Past (circa 1800s) layers which can be clicked on or off by the user. The Present layers include the modern drainage network, watershed boundaries, and reservoirs. The Past layers include the 1800s-era creek systems, tidal marshes, lagoons, and other habitats. All data are developed in ArcGIS software and converted to Google Earth format. To ensure the maps are interesting and engaging, clickable icons pop-up provide information on places to visit, restoration projects, history, plants, and animals. Maps of Santa Clara Valley are available at http://www.valleywater.org/WOW.aspx. Maps of western Alameda County will soon be available at http://acfloodcontrol.org/. Digital interactive maps provide several advantages over paper maps. They are seamless within each map area, and the user can zoom in or out, and tilt, and fly over to explore

  5. Improving Radar Quantitative Precipitation Estimation over Complex Terrain in the San Francisco Bay Area

    Science.gov (United States)

    Cifelli, R.; Chen, H.; Chandrasekar, V.

    2017-12-01

    A recent study by the State of California's Department of Water Resources has emphasized that the San Francisco Bay Area is at risk of catastrophic flooding. Therefore, accurate quantitative precipitation estimation (QPE) and forecast (QPF) are critical for protecting life and property in this region. Compared to rain gauge and meteorological satellite, ground based radar has shown great advantages for high-resolution precipitation observations in both space and time domain. In addition, the polarization diversity shows great potential to characterize precipitation microphysics through identification of different hydrometeor types and their size and shape information. Currently, all the radars comprising the U.S. National Weather Service (NWS) Weather Surveillance Radar-1988 Doppler (WSR-88D) network are operating in dual-polarization mode. Enhancement of QPE is one of the main considerations of the dual-polarization upgrade. The San Francisco Bay Area is covered by two S-band WSR-88D radars, namely, KMUX and KDAX. However, in complex terrain like the Bay Area, it is still challenging to obtain an optimal rainfall algorithm for a given set of dual-polarization measurements. In addition, the accuracy of rain rate estimates is contingent on additional factors such as bright band contamination, vertical profile of reflectivity (VPR) correction, and partial beam blockages. This presentation aims to improve radar QPE for the Bay area using advanced dual-polarization rainfall methodologies. The benefit brought by the dual-polarization upgrade of operational radar network is assessed. In addition, a pilot study of gap fill X-band radar performance is conducted in support of regional QPE system development. This paper also presents a detailed comparison between the dual-polarization radar-derived rainfall products with various operational products including the NSSL's Multi-Radar/Multi-Sensor (MRMS) system. Quantitative evaluation of various rainfall products is achieved

  6. In-situ measurements of seismic velocities in the San Francisco Bay Region; part III

    Science.gov (United States)

    Gibbs, James F.; Fumal, Thomas E.; Borcherdt, Roger D.; Roth, Edward F.

    1977-01-01

    Seismic wave velocities (compressional and shear) are important parameters for estimating the seismic response characteristics of various geologic units when subjected to strong earthquake ground shaking. Seismic velocities of various units often show a strong correlation with the amounts of damage following large earthquakes and have been used as a basis for certain types of seismic zonation studies. In the current program seismic velocities have been measured at 59 locations 1n the San Francisco Bay Region. This report is the third in a series of Open-File Reports and describes the in-situ velocity measurements at locations 35-59. At each location seismic travel times are measured in drill holes, normally at 2.5-m intervals to a depth of 30 m. Geologic logs are determined from drill cuttings, undisturbed (cored) samples, and penetrometer samples. The data provide a detailed comparison of geologic and seismic characteristics and provide parameters for estimating strong earthquake ground motions quantitatively at each of the sites. A major emphasis of this program is to obtain a detailed comparison of geologic and seismic data on a regional scale for use in seismic zonation. There is a variety of geologic and seismic data available in the San Francisco Bay Region for use 1n developing the general zoning techniques which can then be applied to other areas. Shear wave velocities 1n near-surface geologic materials are of especial interest for engineering seismology and seismic zonation studies, yet in general, they are difficult to measure because of contamination by compressional waves. A comparison of various in-situ techniques by Warrick (1974) establishes the reliability of the method utilizing a "horizontal traction" source for sites underlain by bay mud and alluvium. Gibbs, and others (1975a) present data from 12 holes and establishes the reliability of the method for sites underlain by a variety of different rock units and suggest extending the measurements to

  7. Remarkable invasion of San Francisco Bay (California, USA), by the Asian clam Potamocorbula amurensis. I. Introduction and dispersal

    Science.gov (United States)

    Carlton, James T.; Thompson, Janet K.; Schemel, Laurence E.; Nichols, Frederic H.

    1990-01-01

    The euryhaline bivalve mollusc Potamocorbula amurensis (family Corbulidae), a native of China, Japan, and Korea, has recently appeared and become very abundant in San Francisco Bay. This clam appears to have been introduced as veliger larvae in the seawater ballast of cargo vessels. It was first collected in northern San Francisco Bay in late 1986. P, amurensis then spread throughout the estuary within 2 yr and reached densities at some sites exceeding 10 000 m-2 It lives primarily in the subtidal on all substrates (mud, sand, peat, and clay) and is found in the full range of bay salinities (estuary ecosystem. These could include changes in (1) trophic dynamics (through competition with other suspension-feeding and deposit-feeding infauna; changes in benthic community energy flow; availability of a new and abundant prey item for birds, fish, and crabs; and reduction - as a result of its filter feeding - of phytoplankton standmg stock) and (2) benthic dynamics (through inhibition and/or enhancement of infauna due to substrate destabilization; alteration of suspended sediment load of near-bottom water; and change of sediment surface redox balance). The early detection of the appearance and spread of P. amurensis in San Francisco Bay makes this one of the best documented invasions of any estuary in the world.

  8. Social marketing campaign significantly associated with increases in syphilis testing among gay and bisexual men in San Francisco.

    Science.gov (United States)

    Montoya, Jorge A; Kent, Charlotte K; Rotblatt, Harlan; McCright, Jacque; Kerndt, Peter R; Klausner, Jeffrey D

    2005-07-01

    Between 1999 and 2002, San Francisco experienced a sharp increase in early syphilis among gay and bisexual men. In response, the San Francisco Department of Public Health launched a social marketing campaign to increase testing for syphilis, and awareness and knowledge about syphilis among gay and bisexual men. A convenience sample of 244 gay and bisexual men (18-60 years of age) were surveyed to evaluate the effectiveness of the campaign. Respondents were interviewed to elicit unaided and aided awareness about the campaign, knowledge about syphilis, recent sexual behaviors, and syphilis testing behavior. After controlling for other potential confounders, unaided campaign awareness was a significant correlate of having a syphilis test in the last 6 months (odds ratio, 3.21; 95% confidence interval, 1.30-7.97) compared with no awareness of the campaign. A comparison of respondents aware of the campaign with those not aware also revealed significant increases in awareness and knowledge about syphilis. The Healthy Penis 2002 campaign achieved its primary objective of increasing syphilis testing, and awareness and knowledge about syphilis among gay and bisexual men in San Francisco.

  9. Drivers of change in estuarine-coastal ecosystems: Discoveries from four decades of study in San Francisco Bay

    Science.gov (United States)

    Cloern, J.E.; Jassby, A.D.

    2012-01-01

    Poised at the interface of rivers, ocean, atmosphere and dense human settlement, estuaries are driven by a large array of natural and anthropogenic forces. San Francisco Bay exemplifies the fast-paced change occurring in many of the world's estuaries, bays and inland seas in response to these diverse forces. We use observations from this particularly well-studied estuary to illustrate responses to six drivers that are common agents of change where land and sea meet: water consumption and diversion; human modification of sediment supply; introduction of non-native species; sewage input; environmental policy; and climate shifts. In San Francisco Bay, responses to these drivers include, respectively, shifts in the timing and extent of freshwater inflow and salinity intrusion; decreasing turbidity; restructuring of plankton communities; nutrient enrichment; elimination of hypoxia and reduced metal contamination of biota; and food web changes that decrease resistance of the estuary to nutrient pollution. Detection of these changes and discovery of their causes through environmental monitoring have been essential for establishing and measuring outcomes of environmental policies that aim to maintain high water quality and sustain services provided by estuarine-coastal ecosystems. The wide range of variability time scales and the multiplicity of interacting drivers place heavy demands on estuarine monitoring programs. But the San Francisco Bay case study illustrates why the imperative for monitoring has never been greater.

  10. Mercury burdens in Chinese mitten crabs (Eriocheir sinensis) in three tributaries of southern San Francisco Bay, California, USA

    Energy Technology Data Exchange (ETDEWEB)

    Hui, Clifford A. [US Geological Survey, 7801 Folsom Blvd, Suite 101, Sacramento, CA 95826 (United States)]. E-mail: bioinvestigations@sbcglobal.net; Rudnick, Deborah [Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720 (United States); Williams, Erin [US Fish and Wildlife Service, 4001 N. Wilson Way, Stockton, CA 95205 (United States)

    2005-02-01

    Chinese mitten crabs (Eriocheir sinensis), endemic to Asia, were first reported in the San Francisco Bay in 1992. They are now established in nearly all San Francisco Bay tributaries. These crabs accumulate more metals, such as mercury, than crustaceans living in the water column. Because their predators include fish, birds, mammals and humans, their mercury burdens have an exceptional potential to impact the ecosystem and public health. We sought to elucidate the potential threat of mitten crab mercury burdens in three adjacent streams in southern San Francisco Bay, one of which is known to be contaminated with mercury. Mitten crabs had hepatopancreas concentrations of total mercury and methylmercury that did not differ among streams. The maximum burden we measured was below the action level of 1 ppm recommended by the USEPA. Hepatopancreas concentrations of methylmercury declined with increasing crab size, suggesting a mechanism for mercury excretion and that predators might reduce mercury exposure if they select larger crabs. Because mercury may be heterogeneously distributed among tissues, estimation of the impacts of crab mercury burdens on the environment requires more data on the feeding preferences of predators. - Hepatopancreas concentrations of mercury decline with crab size, which may have important consequences for bio-magnification in food webs.

  11. Drivers of change in estuarine-coastal ecosystems: Discoveries from four decades of study in San Francisco Bay

    Science.gov (United States)

    Cloern, James E.; Jassby, Alan D.

    2012-12-01

    Poised at the interface of rivers, ocean, atmosphere and dense human settlement, estuaries are driven by a large array of natural and anthropogenic forces. San Francisco Bay exemplifies the fast-paced change occurring in many of the world's estuaries, bays, and inland seas in response to these diverse forces. We use observations from this particularly well-studied estuary to illustrate responses to six drivers that are common agents of change where land and sea meet: water consumption and diversion, human modification of sediment supply, introduction of nonnative species, sewage input, environmental policy, and climate shifts. In San Francisco Bay, responses to these drivers include, respectively, shifts in the timing and extent of freshwater inflow and salinity intrusion, decreasing turbidity, restructuring of plankton communities, nutrient enrichment, elimination of hypoxia and reduced metal contamination of biota, and food web changes that decrease resistance of the estuary to nutrient pollution. Detection of these changes and discovery of their causes through environmental monitoring have been essential for establishing and measuring outcomes of environmental policies that aim to maintain high water quality and sustain services provided by estuarine-coastal ecosystems. The many time scales of variability and the multiplicity of interacting drivers place heavy demands on estuarine monitoring programs, but the San Francisco Bay case study illustrates why the imperative for monitoring has never been greater.

  12. Mercury burdens in Chinese mitten crabs (Eriocheir sinensis) in three tributaries of southern San Francisco Bay, California, USA

    International Nuclear Information System (INIS)

    Hui, Clifford A.; Rudnick, Deborah; Williams, Erin

    2005-01-01

    Chinese mitten crabs (Eriocheir sinensis), endemic to Asia, were first reported in the San Francisco Bay in 1992. They are now established in nearly all San Francisco Bay tributaries. These crabs accumulate more metals, such as mercury, than crustaceans living in the water column. Because their predators include fish, birds, mammals and humans, their mercury burdens have an exceptional potential to impact the ecosystem and public health. We sought to elucidate the potential threat of mitten crab mercury burdens in three adjacent streams in southern San Francisco Bay, one of which is known to be contaminated with mercury. Mitten crabs had hepatopancreas concentrations of total mercury and methylmercury that did not differ among streams. The maximum burden we measured was below the action level of 1 ppm recommended by the USEPA. Hepatopancreas concentrations of methylmercury declined with increasing crab size, suggesting a mechanism for mercury excretion and that predators might reduce mercury exposure if they select larger crabs. Because mercury may be heterogeneously distributed among tissues, estimation of the impacts of crab mercury burdens on the environment requires more data on the feeding preferences of predators. - Hepatopancreas concentrations of mercury decline with crab size, which may have important consequences for bio-magnification in food webs

  13. Transferência do fator caturra para o cultivar Mundo Novo de Coffea arabica Transfer of the CT gene to Mundo Novo cultivar

    Directory of Open Access Journals (Sweden)

    A. Carvalho

    1972-01-01

    Full Text Available No presente trabalho são relatados os estudos realizados visando à introdução do gene Ct (caturra que contribui para reduzir a altura da planta, no cultivar Mundo" Novo de Coffea arabica.Estudaram-se, em ensaios de produtividade, as populações Fv F.,, F3 e F4. Nessas populações e principalmente entre os descendentes dos "caféeiros H 2077-2-5 e H 2077-2-12, foram selecionadas plantas homozigotas para os alelos Ct e também para os alelos responsáveis pela cor do fruto xc ou Xc. Essas combinações foram denominadas 'Catuaí Amarelo' e 'Catuaí Vermelho', respectivamente, e suas características são apresentadas. Os novos cultivares vêm-se mostrando de interesse econômico para as regiões cafeeiras não somente pelo porte pequeno, mas também pela produtividade, pelo vigor vegetativo e pela precocidade.The successful transfer of the Ct gene for short internode to the tall cultivar of Coffea arábica'Mundo Novo' is reported. Individual selections were carried out in the F1, F2, F3 and F4 generations. It was found that early selection in the F2 generation was quite effective. A remarkably good correlation was found between productitivity of F2 plants and the yield of the F3 and F4 generations. Plants of the F4 generation have shown reasonable uniformity and high yield in several trials. The new selections showed to be early producers. Two new cultivars were released namely 'Catuaí Amarelo' and 'Catuaí Vermelho'. The former has yellow fruits whereas the latter has red fruits. The plants are much shorter that the ones of Mundo Novo. The new cultivars have a very strong secondary and tertiary branching. Because of these characteristics Catuaí Amarelo and Catuaí Vermelho are being planted in large scale replacing the tall cultivars.

  14. Guidelines for sustainable building design: Recommendations from the Presidio of San Francisco energy efficiency design charrette

    Energy Technology Data Exchange (ETDEWEB)

    Brown, K.; Sartor, D.; Greenberg, S. [and others

    1996-05-01

    In 1994, the Bay Chapter of the Association of Energy Engineers{reg_sign} organized a two-day design charrette for energy-efficient redevelopment of buildings by the National Park Services (NPS) at the Presidio of San Francisco. This event brought together engineers, researchers, architects, government officials, and students in a participatory environment to apply their experience to create guidelines for the sustainable redesign of Presidio buildings. The venue for the charrette was a representative barracks building located at the Main Post of the Presidio. Examination of this building allowed for the development of design recommendations, both for the building and for the remainder of the facilities. The charrette was organized into a committee structure consisting of: steering, measurement and monitoring, modeling, building envelope and historic preservation (architectural), HVAC and controls, lighting, and presentation. Prior to the charrette itself, the modeling and measurement/monitoring committees developed substantial baseline data for the other committees during the charrette. An integrated design approach was initiated through interaction between the committees during the charrette. Later, committee reports were cross-referenced to emphasize whole building design and systems integration.

  15. Criminalization, legalization or decriminalization of sex work: what female sex workers say in San Francisco, USA.

    Science.gov (United States)

    Lutnick, Alexandra; Cohan, Deborah

    2009-11-01

    Sex work is a criminal offence in San Francisco, USA, and sex work advocates have so far unsuccessfully campaigned for decriminalizing it. Some groups argue that the decriminalization movement does not represent the voices of marginalized sex workers. Using qualitative and quantitative data from the Sex Worker Environmental Assessment Team Study, we investigated the perspectives and experiences of a range of female sex workers regarding the legal status of sex work and the impact of criminal law on their work experiences. Forty women were enrolled in the qualitative phase in 2004 and 247 women in the quantitative phase in 2006-07. Overall, the women in this study seemed to prefer a hybrid of legalization and decriminalization. The majority voiced a preference for removing statutes that criminalize sex work in order to facilitate a social and political environment where they had legal rights and could seek help when they were victims of violence. Advocacy groups need to explore the compromises sex workers are willing to make to ensure safe working conditions and the same legal protections afforded to other workers, and with those who are most marginalized to better understand their immediate needs and how these can be met through decriminalization.

  16. Changes in causes of death among persons with AIDS: San Francisco, California, 1996-2011.

    Science.gov (United States)

    Schwarcz, Sandra K; Vu, Annie; Hsu, Ling Chin; Hessol, Nancy A

    2014-10-01

    The increased life expectancy among HIV-infected persons treated with combination antiretroviral therapy (ART), risk behaviors, and co-morbidities associated with ART place HIV-infected persons at risk for non-HIV-related causes of death. We used the San Francisco HIV/AIDS registry to identify deaths that occurred from January 1996 through December 2011. Temporal trends in AIDS- and non-AIDS-related mortality rates, the proportion of underlying and contributory causes of death, and the ratio of observed deaths in the study population to expected number of deaths among California men aged 20-79 (standardized mortality ratio [SMR]) of underlying causes of death were examined. A total of 5338 deaths were identified. The annual AIDS-related death rate (per 100 deaths) declined from 10.8 in 1996 to 0.9 in 2011 (pdeath rate from non-AIDS-related causes declined from 2.1 in 1996 to 0.9 in 2011 (pdeaths due to all types of heart disease combined, all non-AIDS cancers combined, mental disorders resulting from substance abuse, drug overdose, suicide and chronic obstructive pulmonary disease increased significantly over time. The SMRs for liver diseased decreased significantly over time but remained elevated. Our data highlight the importance of age-related causes of death as well as deaths from causes that are, at least in part, preventable.

  17. Geophysical Analysis of Young Monogenetic Volcanoes in the San Francisco Volcanic Field, Arizona

    Science.gov (United States)

    Rees, S.; Porter, R. C.; Riggs, N.

    2017-12-01

    The San Francisco Volcanic Field (SFVF), located in northern Arizona, USA, contains some of the youngest intracontinental volcanism within the United States and, given its recent eruptive history, presents an excellent opportunity to better understand how these systems behave. Geophysical techniques such as magnetics, paleomagnetics, and seismic refraction can be used to understand eruptive behavior and image shallow subsurface structures. As such, they present an opportunity to understand eruptive processes associated with the monogenetic volcanism that is common within the SFVF. These techniques are especially beneficial in areas where erosion has not exposed shallow eruptive features within the volcano. We focus on two volcanoes within the SFVF, Merriam Crater and Crater 120 for this work. These are thought to be some of the youngest volcanoes in the field and, as such, are well preserved. Aside from being young, they both exhibit interesting features such as multiple vents, apparent vent alignment, and lack of erosional features that are present at many of the other volcanoes in the SFVF, making them ideal for this work. Initial results show that shallow subsurface basaltic masses can be located using geophysical techniques. These masses are interpreted as dikes or lava flows that are covered by younger scoria. Propagating dikes drive eruptions at monogenetic volcanoes, which often appear in aligned clusters. Locating these features will further the understanding of how magma is transported and how eruptions may have progressed.

  18. Breast cancer characteristics of Vietnamese women in the Greater San Francisco Bay Area.

    Science.gov (United States)

    Lin, Scarlett S; Phan, John C; Lin, Albert Y

    2002-03-01

    To examine breast cancer characteristics of women of Vietnamese ancestry living in the San Francisco Bay Area in comparison with those of other racial or ethnic groups in the same area. Data were obtained from the population-based Greater Bay Area Cancer Registry, part of the Surveillance, Epidemiology, and End Results program. We included breast cancer cases diagnosed from 1988 to 1999 and compared the age at diagnosis, stage and histologic grade at diagnosis, estrogen- and progesterone-receptor status, and surgery types across racial or ethnic groups. We also modeled the effect of patient and clinical characteristics and hospital and physician on the racial or ethnic variations in surgery type. Vietnamese women were younger at diagnosis than other racial or ethnic subgroups (mean age, 51.0 years), with 49.6% of the diagnoses occurring in patients younger than 50. They were also significantly more likely to have received mastectomy for their in situ and localized tumors (61.1% having mastectomy) than women of other racial or ethnic groups. The increased likelihood of having mastectomy among Vietnamese women was not affected greatly by age, year of diagnosis, tumor stage, histologic grade, or physician, but was partly attributable to the hospital of diagnosis. The effects of a lower mean age at diagnosis and the reasons for an unexpectedly higher percentage of mastectomies in this Asian subgroup should be further explored.

  19. Does Wind Discourage Sustainable Transportation Mode Choice? Findings from San Francisco, California, USA

    Directory of Open Access Journals (Sweden)

    Hyungkyoo Kim

    2016-03-01

    Full Text Available This paper explores whether and to what extent wind discourages sustainable transportation mode choice, which includes riding public transportation, bicycling, and walking. A six month-long field study was carried out at four locations in San Francisco, a city that has been promoting sustainable transportation mode choice but that experiences high wind levels. It involved surveying pedestrians and on-site recording of microclimate data using various instruments. The survey adopted a mixed-method approach to collect both quantitative and qualitative data. Statistical analyses using Kruskal Wallis tests and ordinal logistic regression models identified the significant effect of wind speed on San Francisco’s residents in estimating their discouragement for waiting at transit stop without shelter, bicycling, and walking. Qualitative data revealed a deeper understanding of how wind influences their sustainable transportation mode choice. This research argues for the need to adopt climate-based efforts in urban planning and policy and sheds light on the climate resilience of cities

  20. Fundamentos teológicos de la censura en Francisco Suárez

    Directory of Open Access Journals (Sweden)

    Manuel Lázaro Pulido

    2017-09-01

    Full Text Available La censura es un acto recogido dentro del Código de Derecho Canónico. La teología subyacente se inscribe dentro de la historia de la salvación propia del concilio Vaticano II. Varios siglos antes, el maestro jesuita Francisco Suárez reflexionó sobre la censura en un voluminoso tratado (Disputationum de censuris…, en el que anticipa los elementos pertenecientes a la censura que aparecen en el actual CDC. Suárez realiza una lectura teológica en el que destaca el carácter medicinal de la censura, a partir de la lectura sacramental de la pena y desde un antropología de la voluntad, que supone una apuesta por la prevención del hombre y su salvación, antes que por su carácter penal, o si se quiere por dotar a la ley penal de un carácter salvífico.

  1. Elevational dependence of projected hydrologic changes in the San Francisco Estuary and watershed

    Science.gov (United States)

    Knowles, N.; Cayan, D.R.

    2004-01-01

    California's primary hydrologic system, the San Francisco Estuary and its upstream watershed, is vulnerable to the regional hydrologic consequences of projected global climate change. Previous work has shown that a projected warming would result in a reduction of snowpack storage leading to higher winter and lower spring-summer streamflows and increased spring-summer salinities in the estuary. The present work shows that these hydrologic changes exhibit a strong dependence on elevation, with the greatest loss of snowpack volume in the 1300-2700 m elevation range. Exploiting hydrologic and estuarine modeling capabilities to trace water as it moves through the system reveals that the shift of water in mid-elevations of the Sacramento river basin from snowmelt to rainfall runoff is the dominant cause of projected changes in estuarine inflows and salinity. Additionally, although spring-summer losses of estuarine inflows are balanced by winter gains, the losses have a stronger influence on salinity since longer spring-summer residence times allow the inflow changes to accumulate in the estuary. The changes in inflows sourced in the Sacramento River basin in approximately the 1300-2200 m elevation range thereby lead to a net increase in estuarine salinity under the projected warming. Such changes would impact ecosystems throughout the watershed and threaten to contaminate much of California's freshwater supply.

  2. Predator removal and nesting waterbird success at San Francisco Bay, California

    Science.gov (United States)

    Meckstroth, A.M.; Miles, A.K.

    2005-01-01

    The efficacy of long-term predator removal in urbanized areas is poorly understood. The impact of predation on ground-nesting waterbirds, as well as predator abundance and composition in predator removal versus non-removal or reference sites were examined at South San Francisco Bay. The success of natural nests and predator activity was monitored using track plates, trip cameras, wire haircatchers and simulated nests. Removal sites had higher nest densities, but lower hatching success than reference sites. Predator composition and abundance were not different at the removal and reference sites for any predator other than feral Cat (Felis domesticus). Striped Skunk (Mephitis mephitis) comprised the majority (84%) of predators removed, yet remained the most abundant predators in removal and reference sites. Urban environments provide supplemental food that may influence skunks and other nest predators to immigrate into vacancies created by predator removal. Based on the findings from this study, predator removal should be applied intensively over a larger geographic area in order to be a viable management strategy for some mammalian species in urbanized areas.

  3. Acoustic Doppler velocimeter backscatter for quantification of suspended sediment concentration in South San Francisco Bay, USA

    Science.gov (United States)

    Öztürk, Mehmet; Work, Paul A.

    2016-01-01

    A data set was acquired on a shallow mudflat in south San Francisco Bay that featured simultaneous, co-located optical and acoustic sensors for subsequent estimation of suspended sediment concentrations (SSC). The optical turbidity sensor output was converted to SSC via an empirical relation derived at a nearby site using bottle sample estimates of SSC. The acoustic data was obtained using an acoustic Doppler velocimeter. Backscatter and noise were combined to develop another empirical relation between the optical estimates of SSC and the relative backscatter from the acoustic velocimeter. The optical and acoustic approaches both reproduced similar general trends in the data and have merit. Some seasonal variation in the dataset was evident, with the two methods differing by greater or lesser amounts depending on which portion of the record was examined. It is hypothesized that this is the result of flocculation, affecting the two signals by different degrees, and that the significance or mechanism of the flocculation has some seasonal variability. In the earlier portion of the record (March), there is a clear difference that appears in the acoustic approach between ebb and flood periods, and this is not evident later in the record (May). The acoustic method has promise but it appears that characteristics of flocs that form and break apart may need to be accounted for to improve the power of the method. This may also be true of the optical method: both methods involve assuming that the sediment characteristics (size, size distribution, and shape) are constant.

  4. Basta de perseguir al pensamiento disidente: ¡Libertad al profesor Francisco Toloza!

    Directory of Open Access Journals (Sweden)

    Néstor Kohan

    2013-07-01

    Full Text Available Todo el tiempo encarcelan a nuestros compañeros. Buscan cansarnos y desgastarnos.  No  hay  mes  que  no  haya  que escribir  solidarizándose con algún revolucionario que acaban de encarcelar. ¿A esto llaman “libertad”? ¿A esto denominan “pluralismo”? ¿Esto es “el mundo libre”? ¡Por favor! Largan a uno y al día siguiente hay otro encarcelado. Acaban de soltar al cantante y compositor Julián Conrado y al mismo tiempo encarcelan al profesor Francisco Toloza. Nos mantienen “ocupados” pidiendo y reclamando todo el tiempo “suelten a fulano”, “liberen a mengano”. En Colombia. También en Argentina. En Paraguay. En todo el continente. No acabamos de ir a ver a un dirigente piquetero a la cárcel que ya hay otro campesino que está preso. No terminan de soltar a un cantante popular que ya metieron tras las rejas a un conocido profesor universitario. Y en ese vaivén se nos va la vida. Visitando presos, escribiendo todo el tiempo estas cartas de solidaridad, tratando de frenar la represión, la persecución, la demonización. ¿Hasta cuándo?

  5. El acuerdo cubano-americano y la diplomacia del papa Francisco

    Directory of Open Access Journals (Sweden)

    Constanza Mazzina

    2017-12-01

    Full Text Available El acuerdo celebrado entre Cuba y Estados Unidos en el último diciembre de 2014 por el que se acordó la reanudación de las relaciones entre ambos países, después de más de cincuenta años de interrupción, demuestra un cambio histórico y una oportunidad recíproca. El presente artículo hace un recorrido por las relaciones bilaterales en clave histórico-política para luego revisar los hechos que desembocaron en el acuerdo, teniendo en cuenta que este implicó una negociación compleja y el esfuerzo de una serie de actores heterogéneos. Entre los distintos actores, el artículo destaca la actuación del papa Francisco como posibilitador del acuerdo y constructor del puente del diálogo entre Obama y Raúl Castro. Finalmente se introduce y reflexiona acerca de los puntos aún controversiales para el avance de las relaciones bilaterales.

  6. Leadership lessons from curricular change at the University of California, San Francisco, School of Medicine.

    Science.gov (United States)

    Loeser, Helen; O'Sullivan, Patricia; Irby, David M

    2007-04-01

    After successive Liaison Committee on Medical Education accreditation reports that criticized the University of California, San Francisco, School of Medicine for lack of instructional innovation and curriculum oversight, the dean issued a mandate for curriculum reform in 1997. Could a medical school that prided itself on innovation in research and health care do the same in education? The authors describe their five-phase curriculum change process and correlate this to an eight-step leadership model. The first phase of curricular change is to establish a compelling need for change; it requires leaders to create a sense of urgency and build a guiding coalition to achieve action. The second phase of curriculum reform is to envision a bold new curriculum; leaders must develop such a vision and communicate it broadly. The third phase is to design curriculum and obtain the necessary approvals; this requires leaders to empower broad-based action and generate short-term wins. In the fourth phase, specific courses are developed for the new curriculum, and leaders continue to empower broad-based action, generate short-term wins, consolidate gains, and produce more change. During the fifth phase of implementation and evaluation, leaders need to further consolidate gains, produce more change, and anchor new approaches in the institution. Arising from this experience and the correlation of curricular change phases with leadership steps, the authors identify 27 specific leadership strategies they employed in their curricular reform process.

  7. Primary ciliary dyskinesia: a report from ATS 2001, May 18–23, San Francisco

    Directory of Open Access Journals (Sweden)

    Noone Peadar G

    2001-06-01

    Full Text Available Abstract Primary ciliary dyskinesia (PCD is a genetic disorder of abnormal ciliary structure and function that leads to defective mucociliary clearance, resulting in oto-sino-pulmonary disease, and infertility. The disease is currently under intense investigation by a number of research groups worldwide. At the recent American Thoracic Society meeting in San Francisco in May 2001, two sessions focused on PCD; a symposium session on May 21 with several featured expert speakers was followed by a mini-symposium on Tuesday May 22, with one featured speaker and presentation of nine abstracts covering a range of research topics. Mattias Salathe (University of Miami, USA and Stephen Brody (Washington University, St Louis, USA chaired the symposium session. Presentations focused on the clinical spectrum of PCD, the genetics of PCD, a proteomics approach to detail the structure of cilia, the role of cilia in the embryology of situs laterality, and airway epithelial cell biology. The mini-symposium was chaired by Peadar Noone (University of North Carolina, USA and Malcolm King (University of Alberta, USA and included presentations on the use of PCD as a human disease model, accurate definition of the phenotype using clinical and cell biologic markers, and molecular studies. The latter reports ranged from isolation of a protein involved in ciliary structure and function to genetic studies using linkage analysis and the candidate gene approach. Clinicians and scientists alike displayed considerable interest at both sessions, and there were several lively question–answer sessions.

  8. Breast cancer among American Japanese in the San Francisco Bay area.

    Science.gov (United States)

    Dunn, J E

    1977-12-01

    The Japanese-American population was particularly well suited for the study of cancer occurrence because: 1) An American-born population as well as the immigrant Japanese-American population could be studied; 2) good cancer incidence and mortality data from Japan could be compared with data from the United States; and 3) some differences in the rate of occurrence of several specific cancer sites in Japan as compared with the United States were striking. The most significant of these involved the gastrointestinal tract and sex organs. Data were presented concerning cancer incidence rates for the Japanese-American population of the San Francisco Bay area. The high gastric rates for the Japanese in Japan were reduced in a stepwise fashion in the immigrant Japanese-American population to the American-born Japanese who were approaching the low rate of the United States. Colon cancer rates, which were low in Japan, approached the rates in the United States in both the immigrants from Japan and in Japanese Americans. The low rates of cancers of the breast, uterine corpus, and ovary of Japanese women in Japan and for prostate cancer among men rapidly approached the higher rates for these cancer sites that existed in the United States. A study of nutritional factors related to the increase of cancer of the breast in Japanese Americans is being conducted.

  9. Delta smelt: Life history and decline of a once abundant species in the San Francisco Estuary

    Science.gov (United States)

    Moyle, Peter B.; Brown, Larry R.; Durand, John R; Hobbs, James A.

    2016-01-01

    This paper reviews what has been learned about Delta Smelt and its status since the publication of The State of Bay-Delta Science, 2008 (Healey et al. 2008). The Delta Smelt is endemic to the upper San Francisco Estuary. Much of its historic habitat is no longer available and remaining habitat is increasingly unable to sustain the population. As a listed species living in the central node of California’s water supply system, Delta Smelt has been the focus of a large research effort to understand causes of decline and identify ways to recover the species. Since 2008, a remarkable record of innovative research on Delta Smelt has been achieved, which is summarized here. Unfortunately, research has not prevented the smelt’s continued decline, which is the result of multiple, interacting factors. A major driver of decline is change to the Delta ecosystem from water exports, resulting in reduced outflows and high levels of entrainment in the large pumps of the South Delta. Invasions of alien species, encouraged by environmental change, have also played a contributing role in the decline. Severe drought effects have pushed Delta Smelt to record low levels in 2014–2015. The rapid decline of the species and failure of recovery efforts demonstrate an inability to manage the Delta for the “co-equal goals” of maintaining a healthy ecosystem and providing a reliable water supply for Californians. Diverse and substantial management actions are needed to preserve Delta Smelt.

  10. Avian communities in baylands and artificial salt evaporation ponds of the San Francisco Bay estuary

    Science.gov (United States)

    Takekawa, John Y.; Lu, C.T.; Pratt, R.T.

    2001-01-01

    San Francisco Bay wetlands, seasonal and tidal marshes between the historic low and high tide lines, are now highly fragmented because of development during the past 150 years. Artificial salt pond systems in the Bay are hypersaline and typically support simple assemblages of algae and invertebrates. In order to establish the value of salt ponds for migratory waterbirds, we used datasets to conduct a meta-analysis of avian communities in the baylands and salt ponds of San Pablo Bay. Fifty-three species of waterbirds in the salt ponds represented six foraging guilds: surface feeders, shallow probers, deep probers, dabblers, diving benthivores and piscivores. The total number of species and the Shannon-Weiner diversity index was higher in baylands than in salt ponds during all four seasons. However, overall bird density (number/ha) was higher in salt ponds compared with baylands in the winter and spring, primarily because of large concentrations of benthivores. Cessation of salt production in 1993 and subsequent reduction in water depth resulted in a decline of some diving duck populations that used the salt ponds.

  11. Tipos de tirano y resistencia en Francisco Suárez

    Directory of Open Access Journals (Sweden)

    Pablo Font Oporto

    2017-09-01

    Full Text Available El presente artículo pretende analizar la discusión que Francisco Suárez mantiene con las tesis contrarias a la distinción entre tipos de tirano en la cuestión del tiranicidio (Defensio fidei, Libro VI, capítulo IV, números 10-13. Para esta visión no le es lícito a una persona privada matar a ninguno de los dos tipos de tirano; sólo es posible darles muerte en legítima defensa, porque se entiende que en tal caso se actúa en ejercicio de autoridad pública. Suárez acaba admitiendo esta tesis en el número 13, lo que parece contradecirse con lo sostenido en el número 7, donde se aceptaba la muerte del usurpador por cualquier particular. Sin embargo, en el fondo mantiene la diferencia entre ambos tipos de tirano, por cuanto que en el caso del usurpador sostiene que siempre se dan las condiciones para alegar legítima defensa. Queda sin aclarar qué ocurre en tal caso con las condiciones dispuestas en los números 8 y 9.

  12. The Role of Tidal Marsh Restoration in Fish Management in the San Francisco Estuary

    Directory of Open Access Journals (Sweden)

    Bruce Herbold

    2014-03-01

    Full Text Available   Tidal marsh restoration is an important management issue in the San Francisco Estuary (estuary. Restoration of large areas of tidal marsh is ongoing or planned in the lower estuary (up to 6,000 ha, Callaway et al. 2011. Large areas are proposed for restoration in the upper estuary under the Endangered Species Act biological opinions (3,237 ha and the Bay Delta Conservation Plan (26,305 ha. In the lower estuary, tidal marsh has proven its value to a wide array of species that live within it (Palaima 2012. In the Sacramento–San Joaquin Delta (Delta, one important function ascribed to restoration of freshwater tidal marshes is that they make large contributions to the food web of fish in open waters (BDCP 2013. The Ecosystem Restoration Program ascribed a suite of ecological functions to tidal marsh restoration, including habitat and food web benefits to native fish (CDFW 2010. This background was the basis for a symposium, Tidal Marshes and Native Fishes in the Delta: Will Restoration Make a Difference? held at the University of California, Davis, on June 10, 2013. This paper summarizes conclusions the authors drew from the symposium. 

  13. Survival of postfledging Forster's terns in relation to mercury exposure in San Francisco Bay

    Science.gov (United States)

    Ackerman, Joshua T.; Eagles-Smith, Collin A.; Takekawa, John Y.; Iverson, S.A.

    2008-01-01

    We examined factors influencing mercury concentrations in 90 fledgling Forster's terns (Sterna forsteri) and evaluated whether mercury influenced postfledging survival in San Francisco Bay, California. Mercury concentrations (??SE) in chicks 21-29 days old (just before fledging) were 0.33 ?? 0.01 ??g g-1 ww for blood and 6.44 ?? 0.28 ??g g -1 fw for breast feathers. Colony site had an overriding influence on fledgling contamination, however hatching date and age also affected blood, but not feather, mercury concentrations. Blood mercury concentrations decreased by 28% during the 50-day hatching period and increased with chick age by 30% during the last week prior to fledging. Using radio-telemetry, we calculated that cumulative survival during the 35-day postfledging time period was 0.81 ?? 0.09 (SE). Postfledging survival rates increased with size-adjusted mass, and cumulative survival probability was 61% lower for terns with the lowest, compared to the highest, observed masses. Conversely, survival was not influenced by blood mercury concentration, time since fledging, sex, or hatch date. Mercury concentrations in breast feathers of fledglings found dead at nesting colonies also were no different than those in live chicks. Our results indicate that colony site, hatching date, and age influenced mercury concentrations in fledgling Forster's terns, but that mercury did not influence postfledging survival. ?? 2008 Springer Science+Business Media, LLC.

  14. Bilingual Experience in the Hungarian and German Immigrant Communities of the San Francisco Bay Area

    Directory of Open Access Journals (Sweden)

    Gergely Tóth

    2012-01-01

    Full Text Available Studies on the interaction of languages are gaining importance in today’s world, characterized by accelerated migration and increasing cultural exchange. Unlike most research in this field, which concentrate on one embedded language against a matrix language, this fieldwork-based study examines the linguistic life in two immigrant populations, Hungarian and German, against the background of English. The primary focus of this article is the description of the bilingual and bicultural experience of the two groups. The discussion of language and identity will take a central place in the paper, and diglossia, bilingualism, loyalty, and language as social behavior will also be touched upon (section 4. This is complemented by a socio-historical portrayal of these speech communities of San Francisco, set forth in the preceding section 3. Section 5 provides an outline of the informant sets, spanning three generations in each linguistic cohort, and illustrates the subjects’ attitude towards maintenance. The final, sixth section offers qualitative and quantitative comparative statements about the results of linguistic interference and the ongoing attrition process, thus contributing to our understanding of contact linguistic mechanisms, and shedding light on specific grammatical and lexical features that are most prone to attritional forces.

  15. Impact of certification on fruit producers in the Sao Francisco Valley in Brazil

    Directory of Open Access Journals (Sweden)

    Andréa Cristina DÖRR

    2009-01-01

    Full Text Available Producers and exporters of fresh fruits and vegetables from developingcountries like Brazil are increasingly required to demonstrate the safety andtraceability of their produce up to the consumption stage. In fact, the Brazilianexport market is still relatively underdeveloped, with an export share of only2.4% of the total produced volume. However, certification may also have theeffect of a non-tariff trade barrier, undermining the capability and financialability of especially small-scale farmers in exporting to international markets.This study, therefore, aims at providing an economic analysis of certification onmango and grapes producers. A survey of 303 grapes and mango farmers wasconducted in 2006 in the Juazeiro and Petrolina regions of the Sao FranciscoValley in Brazil. Certified and non-certified farmers as well as those in processto obtain certification were included in the sample. Empirical analysis using alogit model shows that grapes farmers have higher probability to certify thanmango growers. There are two variables which have a positive and significanteffect: education and experience. However, small-scale farms, the dependencyon non-agricultural income and a trust-based arrangement have a negative butsignificant effect.

  16. Predictors of gambling behaviors in Filipino Americans living in Honolulu or San Francisco.

    Science.gov (United States)

    Kim, Wooksoo; Kim, Isok; Nochajski, Thomas H

    2012-06-01

    This study compared the prevalence and predictors of gambling behaviors between Filipino Americans who live in San Francisco (S.F.) or Honolulu. Data from the 1998-1999 Filipino American Community Epidemiological Survey were used to answer two research questions: (1) What are the prevalence and types of gambling behaviors among Filipino Americans and (2) What are the protective/risk factors of heavy gambling for Filipino Americans in S.F. and Honolulu? Overall, S.F. Filipino Americans had a higher level of participation in gambling, and the odds of gambling increased among older age groups, males, those who were US-born, and those with more health problems. Multinomial logistic regression analyses revealed that factors associated with infrequent and regular gambling participation were different between the S.F. group (older, male, higher education) and Honolulu group (male, US-born, more health concerns). Differential gambling environments, i.e., wide open gambling in S.F. and the restrictive gambling in Honolulu, may contribute to gambling participation and predictors of risk gambling Filipino Americans living in Honolulu and S.F. Policy makers and health professionals need to be aware of these differences to serve this population more effectively.

  17. Examining the Effects of Transphobic Discrimination and Race on HIV Risk Among Transwomen in San Francisco.

    Science.gov (United States)

    Arayasirikul, Sean; Wilson, Erin C; Raymond, Henry F

    2017-09-01

    Transwomen, in particular transwomen of color (TWOC), are among the most vulnerable populations at risk for HIV. This secondary analysis is organized using a gender minority stress framework to examine the effects of transphobic discrimination and race on HIV risk factors. We describe the sample of 149 HIV- adult transwomen in San Francisco and use binary logistic regression to examine the relationship between levels of transphobic discrimination and TWOC status on binge drinking and condomless receptive anal intercourse (CRAI), controlling for potential confounders. Those with high levels of transphobic discrimination had 3.59 fold greater odds of engaging in binge drinking compared to those who reported a low level of transphobic discrimination (95% CI 1.284-10.034; P = 0.015). TWOC had nearly threefold greater odds of CRAI compared to white transwomen (95% CI 1.048-8.464; P = 0.040). We discuss implications for gender minority stress research and future interventions for this population.

  18. Bathymetry and digital elevation models of Coyote Creek and Alviso Slough, South San Francisco Bay, California

    Science.gov (United States)

    Foxgrover, Amy C.; Finlayson, David P.; Jaffe, Bruce E.; Fregoso, Theresa A.

    2012-01-05

    In 2010 the U.S. Geological Survey (USGS), Pacific Coastal and Marine Science Center completed three cruises to map the bathymetry of the main channel and shallow intertidal mudflats in the southernmost part of south San Francisco Bay. The three surveys were merged to generate comprehensive maps of Coyote Creek (from Calaveras Point east to the railroad bridge) and Alviso Slough (from the bay to the town of Alviso) to establish baseline bathymetry prior to the breaching of levees adjacent to Alviso and Guadalupe Sloughs as part of the South Bay Salt Pond Restoration Project (http://www.southbayrestoration.org). Since 2010 the USGS has conducted twelve additional surveys to monitor bathymetric change in this region as restoration progresses.The bathymetry surveys were conducted using the state-of-the-art research vessel R/V Parke Snavely outfitted with an interferometric sidescan sonar for swath mapping in extremely shallow water. This publication provides high-resolution bathymetric data collected by the USGS. For the 2010 baseline survey we have merged the bathymetry with aerial lidar data that were collected for the USGS during the same time period to create a seamless, high-resolution digital elevation model (DEM) of the study area. The series of bathymetry datasets are provided at 1 m resolution and the 2010 bathymetric/topographic DEM at 2 m resolution. The data are formatted as both X, Y, Z text files and ESRI Arc ASCII files that are accompanied by Federal Geographic Data Committee (FGDC) compliant metadata.

  19. HIV Prevalence, Sexual Partners, Sexual Behavior and HIV Acquisition Risk Among Trans Men, San Francisco, 2014.

    Science.gov (United States)

    McFarland, Willi; Wilson, Erin C; Raymond, Henry F

    2017-12-01

    We surveyed 122 trans men using a hybrid sampling method that included randomly selected physical and online venues and peer referral to measure HIV prevalence and risk behaviors. HIV prevalence was 0% (one-sided 97.5% confidence interval 0-3.3%). Of 366 partnerships described, 44.8% were with cisgender women, 23.8% with cisgender men, 20.8% with trans men, and 10.7% with trans women. Condomless receptive anal and front hole/vaginal sex averaged one to three episodes per six months. HIV prevalence in trans men is likely closer to heterosexual cisgender men and women in San Francisco than trans women or MSM. Prevention prioritizing trans women and MSM, coupled with individualized and relevant sexual health education for trans men with partners from these populations, may best address the HIV prevention needs of trans men. Systematic collection of transgender status in Census and health data is needed to understand other health disparities among trans men.

  20. Rescaled range analysis of streamflow records in the São Francisco River Basin, Brazil

    Science.gov (United States)

    Araujo, Marcelo Vitor Oliveira; Celeste, Alcigeimes B.

    2018-01-01

    Hydrological time series are sometimes found to have a distinctive behavior known as long-term persistence, in which subsequent values depend on each other even under very large time scales. This implies multiyear consecutive droughts or floods. Typical models used to generate synthetic hydrological scenarios, widely used in the planning and management of water resources, fail to preserve this kind of persistence in the generated data and therefore may have a major impact on projects whose design lives span for long periods of time. This study deals with the evaluation of long-term persistence in streamflow records by means of the rescaled range analysis proposed by British engineer Harold E. Hurst, who first observed the phenomenon in the mid-twentieth century. In this paper, Hurst's procedure is enhanced by a strategy based on statistical hypothesis testing. The case study comprises the six main hydroelectric power plants located in the São Francisco River Basin, part of the Brazilian National Grid. Historical time series of inflows to the major reservoirs of the system are investigated and 5/6 sites show significant persistence, with values for the so-called Hurst exponent near or greater than 0.7, i.e., around 40% above the value 0.5 that represents a white noise process, suggesting that decision makers should take long-term persistence into consideration when conducting water resources planning and management studies in the region.