WorldWideScience

Sample records for fr19oc10p issuer review

  1. 75 FR 82277 - Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Requirements Under the Patient...

    Science.gov (United States)

    2010-12-30

    ...-AA06 Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Requirements Under the Patient... Register (FR Doc 2010-29596 (75 FR 74864)) entitled ``Health Insurance Issuers Implementing Medical Loss... request for comments entitled ``Health Insurance Issuers Implementing Medical Loss Ratio (MLR...

  2. 76 FR 4231 - Issuer Review of Assets in Offerings of Asset-Backed Securities

    Science.gov (United States)

    2011-01-25

    .... The issuing entity is designed to be a passive entity, and in order to meet the definition of ABS... other issuers, and because of the structure of ABS issuers as typically passive pools of assets, the... commentator, such originators use electronic decision-making systems as a first filter for applications. Most...

  3. 76 FR 46677 - Requirements for Group Health Plans and Health Insurance Issuers Relating to Coverage of...

    Science.gov (United States)

    2011-08-03

    ... Requirements for Group Health Plans and Health Insurance Issuers Relating to Coverage of Preventive Services... regulations published July 19, 2010 with respect to group health plans and health insurance coverage offered... plans, and health insurance issuers providing group health insurance coverage. The text of those...

  4. 76 FR 44491 - Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals...

    Science.gov (United States)

    2011-07-26

    ... 37208) entitled, ``Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims..., ``Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals and... external review processes for group health plans and health insurance issuers offering coverage in the...

  5. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

    OpenAIRE

    Lawrenson, Kate; Kar, Siddhartha; McCue, Karen; Kuchenbaeker, Karoline; Michailidou, Kyriaki; Tyrer, Jonathan; Beesley, Jonathan; Ramus, Susan J.; Li, Qiyuan; Delgado, Melissa K.; Lee, Janet M.; Aittomaki, Kristiina; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker

    2016-01-01

    A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10−20), ER-negative BC (P=1.1 × 10−13), BRCA1-associated BC (P=7.7 × 10−16) and triple negative BC (P-diff=2 × 10−5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10...

  6. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

    DEFF Research Database (Denmark)

    Lawrenson, Kate; Kar, Siddhartha; McCue, Karen

    2016-01-01

    A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER......'-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk....

  7. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

    DEFF Research Database (Denmark)

    Lawrenson, Kate; Kar, Siddhartha; McCue, Karen

    2016-01-01

    A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER-n...

  8. 17 CFR 240.10b-18 - Purchases of certain equity securities by the issuer and others.

    Science.gov (United States)

    2010-04-01

    ... authorize Rule 10b-18 purchases by or on behalf of the issuer. (4) Agent independent of the issuer has the... trading volume for that security or, in the event that trading volume data are unavailable, is at least 20... of the security, exclusive of any shares owned by any affiliate; Provided, however, That a block...

  9. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

    Science.gov (United States)

    Lawrenson, Kate; Kar, Siddhartha; McCue, Karen; Kuchenbaeker, Karoline; Michailidou, Kyriaki; Tyrer, Jonathan; Beesley, Jonathan; Ramus, Susan J.; Li, Qiyuan; Delgado, Melissa K.; Lee, Janet M.; Aittomäki, Kristiina; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Arun, Banu K.; Arver, Brita; Bandera, Elisa V.; Barile, Monica; Barkardottir, Rosa B.; Barrowdale, Daniel; Beckmann, Matthias W.; Benitez, Javier; Berchuck, Andrew; Bisogna, Maria; Bjorge, Line; Blomqvist, Carl; Blot, William; Bogdanova, Natalia; Bojesen, Anders; Bojesen, Stig E.; Bolla, Manjeet K.; Bonanni, Bernardo; Børresen-Dale, Anne-Lise; Brauch, Hiltrud; Brennan, Paul; Brenner, Hermann; Bruinsma, Fiona; Brunet, Joan; Buhari, Shaik Ahmad; Burwinkel, Barbara; Butzow, Ralf; Buys, Saundra S.; Cai, Qiuyin; Caldes, Trinidad; Campbell, Ian; Canniotto, Rikki; Chang-Claude, Jenny; Chiquette, Jocelyne; Choi, Ji-Yeob; Claes, Kathleen B. M.; Collonge-Rame, Marie- Agnès; Damette, Alexandre; Barouk-Simonet, Emmanuelle; Bonnet, Françoise; Bubien, Virginie; Sevenet, Nicolas; Longy, Michel; Berthet, Pascaline; Vaur, Dominique; Castera, Laurent; Ferrer, Sandra Fert; Bignon, Yves-Jean; Uhrhammer, Nancy; Coron, Fanny; Faivre, Laurence; Baurand, Amandine; Jacquot, Caroline; Bertolone, Geoffrey; Lizard, Sarab; Leroux, Dominique; Dreyfus, Hélène; Rebischung, Christine; Peysselon, Magalie; Peyrat, Jean-Philippe; Fournier, Joëlle; Révillion, Françoise; Adenis, Claude; Vénat-Bouvet, Laurence; Léone, Mélanie; Boutry-Kryza, Nadia; Calender, Alain; Giraud, Sophie; Verny-Pierre, Carole; Lasset, Christine; Bonadona, Valérie; Barjhoux, Laure; Sobol, Hagay; Bourdon, Violaine; Noguchi, Tetsuro; Remenieras, Audrey; Coupier, Isabelle; Pujol, Pascal; Sokolowska, Johanna; Bronner, Myriam; Delnatte, Capucine; Bézieau, Stéphane; Mari, Véronique; Gauthier-Villars, Marion; Buecher, Bruno; Rouleau, Etienne; Golmard, Lisa; Moncoutier, Virginie; Belotti, Muriel; de Pauw, Antoine; Elan, Camille; Fourme, Emmanuelle; Birot, Anne-Marie; Saule, Claire; Laurent, Maïté; Houdayer, Claude; Lesueur, Fabienne; Mebirouk, Noura; Coulet, Florence; Colas, Chrystelle; Soubrier, Florent; Warcoin, Mathilde; Prieur, Fabienne; Lebrun, Marine; Kientz, Caroline; Muller, Danièle; Fricker, Jean-Pierre; Toulas, Christine; Guimbaud, Rosine; Gladieff, Laurence; Feillel, Viviane; Mortemousque, Isabelle; Bressac-de-Paillerets, Brigitte; Caron, Olivier; Guillaud-Bataille, Marine; Cook, Linda S.; Cox, Angela; Cramer, Daniel W.; Cross, Simon S.; Cybulski, Cezary; Czene, Kamila; Daly, Mary B.; Damiola, Francesca; Dansonka-Mieszkowska, Agnieszka; Darabi, Hatef; Dennis, Joe; Devilee, Peter; Diez, Orland; Doherty, Jennifer A.; Domchek, Susan M.; Dorfling, Cecilia M.; Dörk, Thilo; Dumont, Martine; Ehrencrona, Hans; Ejlertsen, Bent; Ellis, Steve; Gregory, Helen; Miedzybrodzka, Zosia; Morrison, Patrick J.; Donaldson, Alan; Rogers, Mark T.; Kennedy, M. John; Porteous, Mary E.; Brady, Angela; Barwell, Julian; Foo, Claire; Lalloo, Fiona; Side, Lucy E.; Eason, Jacqueline; Henderson, Alex; Walker, Lisa; Cook, Jackie; Snape, Katie; Murray, Alex; McCann, Emma; Engel, Christoph; Lee, Eunjung; Evans, D. Gareth; Fasching, Peter A.; Feliubadalo, Lidia; Figueroa, Jonine; Flesch-Janys, Dieter; Fletcher, Olivia; Flyger, Henrik; Foretova, Lenka; Fostira, Florentia; Foulkes, William D.; Fridley, Brooke L.; Friedman, Eitan; Frost, Debra; Gambino, Gaetana; Ganz, Patricia A.; Garber, Judy; García-Closas, Montserrat; Gentry-Maharaj, Aleksandra; Ghoussaini, Maya; Giles, Graham G.; Glasspool, Rosalind; Godwin, Andrew K.; Goldberg, Mark S.; Goldgar, David E.; González-Neira, Anna; Goode, Ellen L.; Goodman, Marc T.; Greene, Mark H.; Gronwald, Jacek; Guénel, Pascal; Haiman, Christopher A.; Hall, Per; Hallberg, Emily; Hamann, Ute; Hansen, Thomas V. O.; Harrington, Patricia A.; Hartman, Mikael; Hassan, Norhashimah; Healey, Sue; Rookus, M. A.; van Leeuwen, F. E.; van der Kolk, L. E.; Schmidt, M. K.; Russell, N. S.; de Lange, J. L.; Wijnands, R.; Collée, J. M.; Hooning, M. J.; Seynaeve, C.; van Deurzen, C. H. M.; Obdeijn, I. M.; van Asperen, C. J.; Tollenaar, R. A. E. M.; van Cronenburg, T. C. T. E. F.; Kets, C. M.; Ausems, M. G. E. M.; van der Pol, C. C.; van Os, T. A. M.; Waisfisz, Q.; Meijers-Heijboer, H. E. J.; Gómez-Garcia, E. B.; Oosterwijk, J. C.; Mourits, M. J.; de Bock, G. H.; Vasen, H. F.; Siesling, S.; Verloop, J.; Overbeek, L. I. H.; Heitz, Florian; Herzog, Josef; Høgdall, Estrid; Høgdall, Claus K.; Hogervorst, Frans B. L.; Hollestelle, Antoinette; Hopper, John L.; Hulick, Peter J.; Huzarski, Tomasz; Imyanitov, Evgeny N.; Fox, Stephen; Kirk, Judy; Lindeman, Geoff; Price, Melanie; Bowtell, David; deFazio, Anna; Webb, Penny; Isaacs, Claudine; Ito, Hidemi; Jakubowska, Anna; Janavicius, Ramunas; Jensen, Allan; John, Esther M.; Johnson, Nichola; Kabisch, Maria; Kang, Daehee; Kapuscinski, Miroslav; Karlan, Beth Y.; Khan, Sofia; Kiemeney, Lambertus A.; Kjaer, Susanne Kruger; Knight, Julia A.; Konstantopoulou, Irene; Kosma, Veli-Matti; Kristensen, Vessela; Kupryjanczyk, Jolanta; Kwong, Ava; de la Hoya, Miguel; Laitman, Yael; Lambrechts, Diether; Le, Nhu; De Leeneer, Kim; Lester, Jenny; Levine, Douglas A.; Li, Jingmei; Lindblom, Annika; Long, Jirong; Lophatananon, Artitaya; Loud, Jennifer T.; Lu, Karen; Lubinski, Jan; Mannermaa, Arto; Manoukian, Siranoush; Le Marchand, Loic; Margolin, Sara; Marme, Frederik; Massuger, Leon F. A. G.; Matsuo, Keitaro; Mazoyer, Sylvie; McGuffog, Lesley; McLean, Catriona; McNeish, Iain; Meindl, Alfons; Menon, Usha; Mensenkamp, Arjen R.; Milne, Roger L.; Montagna, Marco; Moysich, Kirsten B.; Muir, Kenneth; Mulligan, Anna Marie; Nathanson, Katherine L.; Ness, Roberta B.; Neuhausen, Susan L.; Nevanlinna, Heli; Nord, Silje; Nussbaum, Robert L.; Odunsi, Kunle; Offit, Kenneth; Olah, Edith; Olopade, Olufunmilayo I.; Olson, Janet E.; Olswold, Curtis; O'Malley, David; Orlow, Irene; Orr, Nick; Osorio, Ana; Park, Sue Kyung; Pearce, Celeste L.; Pejovic, Tanja; Peterlongo, Paolo; Pfeiler, Georg; Phelan, Catherine M.; Poole, Elizabeth M.; Pylkäs, Katri; Radice, Paolo; Rantala, Johanna; Rashid, Muhammad Usman; Rennert, Gad; Rhenius, Valerie; Rhiem, Kerstin; Risch, Harvey A.; Rodriguez, Gus; Rossing, Mary Anne; Rudolph, Anja; Salvesen, Helga B.; Sangrajrang, Suleeporn; Sawyer, Elinor J.; Schildkraut, Joellen M.; Schmidt, Marjanka K.; Schmutzler, Rita K.; Sellers, Thomas A.; Seynaeve, Caroline; Shah, Mitul; Shen, Chen-Yang; Shu, Xiao-Ou; Sieh, Weiva; Singer, Christian F.; Sinilnikova, Olga M.; Slager, Susan; Song, Honglin; Soucy, Penny; Southey, Melissa C.; Stenmark-Askmalm, Marie; Stoppa-Lyonnet, Dominique; Sutter, Christian; Swerdlow, Anthony; Tchatchou, Sandrine; Teixeira, Manuel R.; Teo, Soo H.; Terry, Kathryn L.; Terry, Mary Beth; Thomassen, Mads; Tibiletti, Maria Grazia; Tihomirova, Laima; Tognazzo, Silvia; Toland, Amanda Ewart; Tomlinson, Ian; Torres, Diana; Truong, Thérèse; Tseng, Chiu-chen; Tung, Nadine; Tworoger, Shelley S.; Vachon, Celine; van den Ouweland, Ans M. W.; van Doorn, Helena C.; van Rensburg, Elizabeth J.; Van't Veer, Laura J.; Vanderstichele, Adriaan; Vergote, Ignace; Vijai, Joseph; Wang, Qin; Wang-Gohrke, Shan; Weitzel, Jeffrey N.; Wentzensen, Nicolas; Whittemore, Alice S.; Wildiers, Hans; Winqvist, Robert; Wu, Anna H.; Yannoukakos, Drakoulis; Yoon, Sook-Yee; Yu, Jyh-Cherng; Zheng, Wei; Zheng, Ying; Khanna, Kum Kum; Simard, Jacques; Monteiro, Alvaro N.; French, Juliet D.; Couch, Fergus J.; Freedman, Matthew L.; Easton, Douglas F.; Dunning, Alison M.; Pharoah, Paul D.; Edwards, Stacey L.; Chenevix-Trench, Georgia; Antoniou, Antonis C.; Gayther, Simon A.

    2016-01-01

    A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10−20), ER-negative BC (P=1.1 × 10−13), BRCA1-associated BC (P=7.7 × 10−16) and triple negative BC (P-diff=2 × 10−5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10−3) and ABHD8 (P<2 × 10−3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk. PMID:27601076

  10. File list: Unc.PSC.10.AllAg.P19 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.10.AllAg.P19 mm9 Unclassified Pluripotent stem cell P19 SRX1098120,SRX10981...21,SRX1098122,SRX1098124,SRX1098123,SRX1098125 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.10.AllAg.P19.bed ...

  11. 76 FR 55308 - Treatment of Asset-Backed Issuers Under the Investment Company Act

    Science.gov (United States)

    2011-09-07

    ... that NRSROs conduct the type of analysis and review of asset-backed issuers' structures and operations... organizational documents . See supra note 45 and accompanying text. The Commission requests comment on the types.... Revisiting Rule 3a-7 1. Rating Requirements 2. Possible New Conditions for Rule 3a-7 a. Structure and...

  12. ISSUERS OF FINANCIAL INSTRUMENTS

    Directory of Open Access Journals (Sweden)

    Cristian GHEORGHE

    2016-05-01

    Full Text Available The rules laid down by Romanian Capital Market Law and the regulations put in force for its implementation apply to issuers of financial instruments admitted to trading on the regulated market established in Romania. But the issuers remain companies incorporated under Company Law of 1990. Such dual regulations need increased attention in order to observe the legal status of the issuers/companies and financial instruments/shares. Romanian legislator has chosen to implement in Capital Market Law special rules regarding the administration of the issuers of financial instruments, not only rules regarding admitting and maintaining to a regulated market. Thus issuers are, in Romanian Law perspective, special company that should comply special rule regarding board of administration and general shareholders meeting.

  13. 75 FR 74863 - Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Requirements Under the Patient...

    Science.gov (United States)

    2010-12-01

    ... Part III Department of Health and Human Services 45 CFR Part 158 Health Insurance Issuers... 0950-AA06 Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Requirements Under the Patient... health insurance issuers under the Public Health Service Act, as added by the Patient Protection and...

  14. 17 CFR 205.3 - Issuer as client.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Issuer as client. 205.3... ISSUER § 205.3 Issuer as client. (a) Representing an issuer. An attorney appearing and practicing before...'s clients. (b) Duty to report evidence of a material violation. (1) If an attorney, appearing and...

  15. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

    NARCIS (Netherlands)

    K. Lawrenson (Kate); S. Kar (Siddhartha); K. McCue (Karen); Kuchenbaeker, K. (Karoline); K. Michailidou (Kyriaki); J.P. Tyrer (Jonathan); J. Beesley (Jonathan); S.J. Ramus (Susan); Li, Q. (Qiyuan); Delgado, M.K. (Melissa K.); J.M. Lee (Janet M.); K. Aittomäki (Kristiina); I.L. Andrulis (Irene); H. Anton-Culver (Hoda); Arndt, V. (Volker); B.K. Arun (Banu); B. Arver (Brita Wasteson); E.V. Bandera (Elisa); M. Barile (Monica); Barkardottir, R.B. (Rosa B.); D. Barrowdale (Daniel); M.W. Beckmann (Matthias); J. Benítez (Javier); A. Berchuck (Andrew); M. Bisogna (Maria); L. Bjorge (Line); C. Blomqvist (Carl); W.J. Blot (William); N.V. Bogdanova (Natalia); Bojesen, A. (Anders); S.E. Bojesen (Stig); M.K. Bolla (Manjeet K.); B. Bonnani (Bernardo); A.-L. Borresen-Dale (Anne-Lise); H. Brauch (Hiltrud); P. Brennan (Paul); H. Brenner (Hermann); F. Bruinsma (Fiona); J. Brunet (Joan); S.A.B.S. Buhari (Shaik Ahmad Bin Syed); B. Burwinkel (Barbara); R. Butzow (Ralf); S.S. Buys (Saundra); Q. Cai (Qiuyin); T. Caldes (Trinidad); I. Campbell (Ian); Canniotto, R. (Rikki); J. Chang-Claude (Jenny); Chiquette, J. (Jocelyne); Choi, J.-Y. (Ji-Yeob); K.B.M. Claes (Kathleen B.M.); L.S. Cook (Linda S.); A. Cox (Angela); D.W. Cramer (Daniel); S.S. Cross (Simon); C. Cybulski (Cezary); K. Czene (Kamila); M.B. Daly (Mary B.); F. Damiola (Francesca); A. Dansonka-Mieszkowska (Agnieszka); H. Darabi (Hatef); J. Dennis (Joe); P. Devilee (Peter); O. Díez (Orland); J.A. Doherty (Jennifer A.); S.M. Domchek (Susan); C.M. Dorfling (Cecilia); T. Dörk (Thilo); M. Dumont (Martine); H. Ehrencrona (Hans); B. Ejlertsen (Bent); S.D. Ellis (Steve); C. Engel (Christoph); E. Lee (Eunjung); Evans, D.G. (D. Gareth); P.A. Fasching (Peter); L. Feliubadaló (L.); J.D. Figueroa (Jonine); D. Flesch-Janys (Dieter); O. Fletcher (Olivia); H. Flyger (Henrik); L. Foretova (Lenka); F. Fostira (Florentia); W.D. Foulkes (William); B.L. Fridley (Brooke); E. Friedman (Eitan); D. Frost (Debra); Gambino, G. (Gaetana); P.A. Ganz (Patricia A.); J. Garber (Judy); M. García-Closas (Montserrat); A. Gentry-Maharaj (Aleksandra); M. Ghoussaini (Maya); G.G. Giles (Graham); R. Glasspool (Rosalind); A.K. Godwin (Andrew K.); M.S. Goldberg (Mark); D. Goldgar (David); A. González-Neira (Anna); E.L. Goode (Ellen); M.T. Goodman (Marc); M.H. Greene (Mark H.); J. Gronwald (Jacek); P. Guénel (Pascal); C.A. Haiman (Christopher A.); P. Hall (Per); Hallberg, E. (Emily); U. Hamann (Ute); T.V.O. Hansen (Thomas); P. harrington (Patricia); J.M. Hartman (Joost); N. Hassan (Norhashimah); S. Healey (Sue); P.U. Heitz; J. Herzog (Josef); E. Høgdall (Estrid); C.K. Høgdall (Claus); F.B.L. Hogervorst (Frans); A. Hollestelle (Antoinette); J.L. Hopper (John); P.J. Hulick (Peter); T. Huzarski (Tomasz); E.N. Imyanitov (Evgeny); C. Isaacs (Claudine); H. Ito (Hidemi); A. Jakubowska (Anna); R. Janavicius (Ramunas); A. Jensen (Allan); E.M. John (Esther); Johnson, N. (Nichola); M. Kabisch (Maria); D. Kang (Daehee); M.K. Kapuscinski (Miroslav K.); Karlan, B.Y. (Beth Y.); S. Khan (Sofia); L.A.L.M. Kiemeney (Bart); M. Kjaer (Michael); J.A. Knight (Julia); I. Konstantopoulou (I.); V-M. Kosma (Veli-Matti); V. Kristensen (Vessela); J. Kupryjanczyk (Jolanta); A. Kwong (Ava); M. de La Hoya (Miguel); Y. Laitman (Yael); Lambrechts, D. (Diether); N.D. Le (Nhu D.); K. De Leeneer (Kim); K.J. Lester (Kathryn); D.A. Levine (Douglas); J. Li (Jingmei); A. Lindblom (Annika); J. Long (Jirong); A. Lophatananon (Artitaya); J.T. Loud (Jennifer); K.H. Lu (Karen); J. Lubinski (Jan); A. Mannermaa (Arto); S. Manoukian (Siranoush); L. Le Marchand (Loic); S. Margolin (Sara); F. Marme (Frederick); L.F. Massuger (Leon); K. Matsuo (Keitaro); S. Mazoyer (Sylvie); L. McGuffog (Lesley); C.A. McLean (Catriona Ann); I. McNeish (Iain); A. Meindl (Alfons); U. Menon (Usha); Mensenkamp, A.R. (Arjen R.); R.L. Milne (Roger); M. Montagna (Marco); K.B. Moysich (Kirsten); K.R. Muir (K.); A.-M. Mulligan (Anna-Marie); K.L. Nathanson (Katherine); R.B. Ness (Roberta); S.L. Neuhausen (Susan); H. Nevanlinna (Heli); S. Nord (Silje); R.L. Nussbaum (Robert L.); K. Odunsi (Kunle); K. Offit (Kenneth); E. Olah; O.I. Olopade (Olufunmilayo I.); J.E. Olson (Janet); C. Olswold (Curtis); D.M. O'Malley (David M.); I. Orlow (Irene); N. Orr (Nick); A. Osorio (Ana); Park, S.K. (Sue Kyung); C.L. Pearce (Celeste); T. Pejovic (Tanja); P. Peterlongo (Paolo); G. Pfeiler (Georg); C. Phelan (Catherine); E.M. Poole (Elizabeth); K. Pykäs (Katri); P. Radice (Paolo); J. Rantala (Johanna); M.U. Rashid (Muhammad); G. Rennert (Gad); V. Rhenius (Valerie); K. Rhiem (Kerstin); H. Risch (Harvey); G.C. Rodriguez (Gustavo); M.A. Rossing (Mary Anne); Rudolph, A. (Anja); H.B. Salvesen (Helga); Sangrajrang, S. (Suleeporn); Sawyer, E.J. (Elinor J.); J.M. Schildkraut (Joellen); M.K. Schmidt (Marjanka); R.K. Schmutzler (Rita); T.A. Sellers (Thomas A.); C.M. Seynaeve (Caroline); Shah, M. (Mitul); C.-Y. Shen (Chen-Yang); X.-O. Shu (Xiao-Ou); W. Sieh (Weiva); C.F. Singer (Christian); O. Sinilnikova (Olga); S. Slager (Susan); H. Song (Honglin); Soucy, P. (Penny); M.C. Southey (Melissa); M. Stenmark-Askmalm (Marie); D. Stoppa-Lyonnet (Dominique); C. Sutter (Christian); A.J. Swerdlow (Anthony ); Tchatchou, S. (Sandrine); P.J. Teixeira; S.-H. Teo (Soo-Hwang); K.L. Terry (Kathryn); M.B. Terry (Mary Beth); M. Thomassen (Mads); M.G. Tibiletti (Maria Grazia); L. Tihomirova (Laima); S. Tognazzo (Silvia); A.E. Toland (Amanda); I.P. Tomlinson (Ian); D. Torres (Diana); T. Truong (Thérèse); C.-C. Tseng (Chiu-Chen); N. Tung (Nadine); Tworoger, S.S. (Shelley S.); C. Vachon (Celine); Van Den Ouweland, A.M.W. (Ans M.W.); Van Doorn, H.C. (Helena C.); E.J. van Rensburg (Elizabeth); L.J. van 't Veer (Laura); A. Vanderstichele (Adriaan); I. Vergote (Ignace); J. Vijai (Joseph); Wang, Q. (Qin); S. Wang-Gohrke (Shan); J.N. Weitzel (Jeffrey); N. Wentzensen (N.); A.S. Whittemore (Alice); H. Wildiers (Hans); R. Winqvist (Robert); A.H. Wu (Anna); Yannoukakos, D. (Drakoulis); S.-Y. Yoon (Sook-Yee); J-C. Yu (Jyh-Cherng); W. Zheng (Wei); Y. Zheng (Ying); Khanna, K.K. (Kum Kum); J. Simard (Jacques); A.N.A. Monteiro (Alvaro N.); J.D. French (Juliet); F.J. Couch (Fergus); M. Freedman (Matthew); D.F. Easton (Douglas F.); A.M. Dunning (Alison); P.D.P. Pharoah (Paul); S.L. Edwards (Stacey); G. Chenevix-Trench (Georgia); A.C. Antoniou (Antonis C.); S.A. Gayther (Simon); D. Bowtell (David); A. DeFazio (Anna); P. Webb (Penny); M.-A. Collonge-Rame; Damette, A. (Alexandre); E. Barouk-Simonet (Emmanuelle); F. Bonnet (Françoise); V. Bubien (Virginie); N. Sevenet (Nicolas); M. Longy (Michel); P. Berthet (Pascaline); D. Vaur (Dominique); L. Castera (Laurent); S.F. Ferrer; Y.-J. Bignon (Yves-Jean); N. Uhrhammer (Nancy); F. Coron (Fanny); L. Faivre (Laurence); Baurand, A. (Amandine); Jacquot, C. (Caroline); Bertolone, G. (Geoffrey); Lizard, S. (Sarab); D. Leroux (Dominique); H. Dreyfus (Hélène); C. Rebischung (Christine); Peysselon, M. (Magalie); J.-P. Peyrat; J. Fournier (Joëlle); F. Révillion (Françoise); C. Adenis (Claude); L. Vénat-Bouvet (Laurence); M. Léone (Mélanie); N. Boutry-Kryza (N.); A. Calender (Alain); S. Giraud (Sophie); C. Verny-Pierre (Carole); C. Lasset (Christine); V. Bonadona (Valérie); Barjhoux, L. (Laure); H. Sobol (Hagay); V. Bourdon (Violaine); Noguchi, T. (Tetsuro); A. Remenieras (Audrey); I. Coupier (Isabelle); P. Pujol (Pascal); J. Sokolowska (Johanna); M. Bronner (Myriam); C.D. Delnatte (Capucine); Bézieau, S. (Stéphane); Mari, V. (Véronique); M. Gauthier-Villars (Marion); B. Buecher (Bruno); E. Rouleau (Etienne); L. Golmard (Lisa); V. Moncoutier (Virginie); M. Belotti (Muriel); A. de Pauw (Antoine); Elan, C. (Camille); Fourme, E. (Emmanuelle); Birot, A.-M. (Anne-Marie); Saule, C. (Claire); Laurent, M. (Maïté); C. Houdayer (Claude); F. Lesueur (Fabienne); N. Mebirouk (Noura); F. Coulet (Florence); C. Colas (Chrystelle); F. Soubrier; Warcoin, M. (Mathilde); F. Prieur (Fabienne); M. Lebrun (Marine); C. Kientz (Caroline); D.W. Muller (Danièle); J.P. Fricker (Jean Pierre); C. Toulas (Christine); R. Guimbaud (Rosine); L. Gladieff (Laurence); V. Feillel (Viviane); I. Mortemousque (Isabelle); B. Bressac-de Paillerets (Brigitte); O. Caron (Olivier); M. Guillaud-Bataille (Marine); H. Gregory (Helen); Z. Miedzybrodzka (Zosia); P.J. Morrison (Patrick); A. Donaldson (Alan); M.T. Rogers (Mark); M.J. Kennedy (John); M.E. Porteous (Mary); A. Brady (A.); J. Barwell (Julian); Foo, C. (Claire); F. Lalloo (Fiona); L. Side (Lucy); J. Eason (Jacqueline); Henderson, A. (Alex); L.J. Walker (Lisa); J. Cook (Jackie); Snape, K. (Katie); A. Murray (Alexandra); E. McCann (Emma); M.A. Rookus (Matti); F.E. van Leeuwen (F.); L. van der Kolk (Lizet); M.K. Schmidt (Marjanka); N.S. Russell (Nicola); J.L. de Lange (J.); Wijnands, R.; J.M. Collée (Margriet); M.J. Hooning (Maartje); Seynaeve, C.; C.H.M. van Deurzen (Carolien); A.I.M. Obdeijn (Inge-Marie); C.J. van Asperen (Christi); R.A.E.M. Tollenaar (Rob); T.C.T.E.F. van Cronenburg; C.M. Kets; M.G.E.M. Ausems (Margreet); C. van der Pol (Carmen); T.A.M. van Os (Theo); Q. Waisfisz (Quinten); E.J. Meijers-Heijboer (Hanne); E.B. Gómez García (Encarna); J.C. Oosterwijk (Jan); M.J. Mourits (Marjan); G.H. de Bock (Geertruida); H. Vasen (Hans); Siesling, S.; Verloop, J.; L.I.H. Overbeek (Lucy); S.B. Fox (Stephen); J. Kirk (Judy); G.J. Lindeman; M. Price (Melanie)

    2016-01-01

    textabstractA locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 ×

  16. 77 FR 28788 - Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Under the Patient Protection and...

    Science.gov (United States)

    2012-05-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES 45 CFR Part 158 [CMS-9998-IFC3] Health Insurance Issuers..., entitled ``Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Requirements Under the Patient...) requirements for health insurance issuers under section 2718 of the Public Health Service Act, as added by the...

  17. Respirators: APR Issuer Self Study 33461

    Energy Technology Data Exchange (ETDEWEB)

    Chochoms, Michael [Los Alamos National Laboratory

    2016-07-13

    Respirators: APR Issuer Self-Study (course 33461) is designed to introduce and familiarize employees selected as air-purifying respirator (APR) issuers at Los Alamos National Laboratory (LANL) with the responsibilities, limitations, procedures, and resources for issuing APRs at LANL. The goal is to enable these issuers to consistently provide proper, functioning APRs to authorized users

  18. 75 FR 80977 - Disclosure of Payments by Resource Extraction Issuers

    Science.gov (United States)

    2010-12-23

    ...: Tamara Brightwell, Senior Special Counsel, Division of Corporation Finance, or Elliot Staffin, Special Counsel in the Office of International Corporate Finance, Division of Corporation Finance, at (202) 551... issuers would be required to disclose taxes on corporate profits, corporate income, and production and...

  19. 28 CFR 80.4 - Issuer or domestic concern.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Issuer or domestic concern. 80.4 Section 80.4 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) FOREIGN CORRUPT PRACTICES ACT OPINION PROCEDURE § 80.4 Issuer or domestic concern. The request must be submitted by an issuer or domestic concern...

  20. Developing the Market for Local Currency Bonds by Foreign Issuers: Lessons from Asia

    OpenAIRE

    Hoschka, Tobias C.

    2005-01-01

    This paper surveys the experience of countries in the East Asian region that have introduced local currency bonds by foreign issuers. The countries that are examined include Australia; Hong Kong, China; Japan; Republic of Korea; and Singapore. It is suggested that there are sound reasons for many countries to develop the market for foreign issuers. Benefits and potential issues are analyzed, development policies are reviewed, and concrete policy options are discussed for those countries that ...

  1. 76 FR 20367 - Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Off Delaware...

    Science.gov (United States)

    2011-04-12

    ... No. BOEM-2011-0008] Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Off... determination that no competitive interest exists in acquiring a commercial wind lease in the area offshore... a Request for Interest (RFI) in the Federal Register on April 26, 2010 (75 FR 21653). Bluewater Wind...

  2. 43 CFR 17.10 - Judicial review.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Judicial review. 17.10 Section 17.10... Origin § 17.10 Judicial review. Action taken pursuant to section 602 of the act is subject to judicial review as provided in section 603 of the act. [29 FR 16293, Dec. 4, 1964] ...

  3. 78 FR 8190 - Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore North Carolina...

    Science.gov (United States)

    2013-02-05

    ...] Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore North Carolina--Call for... Commercial Leasing for Wind Power Offshore North Carolina (Call), published on December 13, 2012 (77 FR 7204). DATES: BOEM must receive your nomination describing your interest in obtaining a commercial wind lease...

  4. 75 FR 43329 - Interim Final Rules for Group Health Plans and Health Insurance Issuers Relating to Internal...

    Science.gov (United States)

    2010-07-23

    ... 45 CFR Part 147 Interim Final Rules for Group Health Plans and Health Insurance Issuers Relating to... Interim Final Rules for Group Health Plans and Health Insurance Issuers Relating to Internal Claims and... of Labor; Office of Consumer Information and Insurance Oversight, Department of Health and Human...

  5. 76 FR 37037 - Requirements for Group Health Plans and Health Insurance Issuers Relating to Internal Claims and...

    Science.gov (United States)

    2011-06-24

    ... Requirements for Group Health Plans and Health Insurance Issuers Relating to Internal Claims and Appeals and... interim final regulations published July 23, 2010 with respect to group health plans and health insurance..., group health plans, and health insurance issuers providing group health insurance coverage. The text of...

  6. 75 FR 37242 - Requirements for Group Health Plans and Health Insurance Issuers Under the Patient Protection and...

    Science.gov (United States)

    2010-06-28

    ... Requirements for Group Health Plans and Health Insurance Issuers Under the Patient Protection and Affordable... Labor and the Office of Consumer Information and Insurance Oversight of the U.S. Department of Health... guidance to employers, group health plans, and health insurance issuers providing group health insurance...

  7. 75 FR 27121 - Interim Final Rules for Group Health Plans and Health Insurance Issuers Relating to Dependent...

    Science.gov (United States)

    2010-05-13

    ... 45 CFR Parts 144, 146, and 147 Group Health Plans and Health Insurance Issuers Relating to Dependent... 144, 146, and 147 RIN 0991-AB66 Interim Final Rules for Group Health Plans and Health Insurance... requirements for group health plans and health insurance issuers in the group and individual markets under...

  8. 76 FR 37207 - Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals...

    Science.gov (United States)

    2011-06-24

    ... Department of Health and Human Services 45 CFR Part 147 Group Health Plans and Health Insurance Issuers... SERVICES [CMS-9993-IFC2] 45 CFR Part 147 RIN 0938-AQ66 Group Health Plans and Health Insurance Issuers... for group health plans and health insurance coverage in the group and individual markets under...

  9. 75 FR 4713 - Purchases of Certain Equity Securities by the Issuer and Others

    Science.gov (United States)

    2010-01-29

    ... Stock Repurchases?,'' 13 Journal of Applied Corporate Finance, pp. 31-51 (2000) (noting issuers... Price Discovery,'' Journal of Empirical Finance 15, 839-849 (2008). \\45\\ See, e.g., Security Traders...

  10. 75 FR 41726 - Interim Final Rules for Group Health Plans and Health Insurance Issuers Relating to Coverage of...

    Science.gov (United States)

    2010-07-19

    ... Health Plans and Health Insurance Issuers Relating to Coverage of Preventive Services Under the Patient... and health insurance coverage in the group and individual markets under provisions of the Patient... plans and group health insurance issuers for plan years beginning on or after September 23, 2010. These...

  11. 78 FR 39793 - ETF Issuer Solutions Inc., et al.; Notice of Application

    Science.gov (United States)

    2013-07-02

    ... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30568; 812-14080] ETF... sections 12(d)(1)(A) and (B) of the Act. Applicants: ETF Issuer Solutions Inc. (``ETFis''), ETF Actively Managed Trust (``Trust) and ETF Distributors LLC (``Distributor''). Summary of Application: Applicants...

  12. Structural, Mechanical, Anisotropic, and Thermal Properties of AlAs in oC12 and hP6 Phases under Pressure

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2018-05-01

    Full Text Available The structural, mechanical, anisotropic, and thermal properties of oC12-AlAs and hP6-AlAs under pressure have been investigated by employing first-principles calculations based on density functional theory. The elastic constants, bulk modulus, shear modulus, Young’s modulus, B/G ratio, and Poisson’s ratio for oC12-AlAs and hP6-AlAs have been systematically investigated. The results show that oC12-AlAs and hP6-AlAs are mechanically stable within the considered pressure. Through the study of lattice constants (a, b, and c with pressure, we find that the incompressibility of oC12-AlAs and hP6-AlAs is the largest along the c-axis. At 0 GPa, the bulk modulus B of oC12-AlAs, hP6-AlAs, and diamond-AlAs are 76 GPa, 75 GPa, and 74 Gpa, respectively, indicating that oC12-AlAs and hP6-AlAs have a better capability of resistance to volume than diamond-AlAs. The pressure of transition from brittleness to ductility for oC12-AlAs and hP6-AlAs are 1.21 GPa and 2.11 GPa, respectively. The anisotropy of Young’s modulus shows that oC12-AlAs and hP6-AlAs have greater isotropy than diamond-AlAs. To obtain the thermodynamic properties of oC12-AlAs and hP6-AlAs, the sound velocities, Debye temperature, and minimum thermal conductivity at considered pressure were investigated systematically. At ambient pressure, oC12-AlAs (463 K and hP6-AlAs (471 K have a higher Debye temperature than diamond-AlAs (433 K. At T = 300 K, hP6-AlAs (0.822 W/cm·K−1 has the best thermal conductivity of the three phases, and oC12-AlAs (0.809 W/cm·K−1 is much close to diamond-AlAs (0.813 W/cm·K−1.

  13. 8 CFR 287.10 - Expedited internal review process.

    Science.gov (United States)

    2010-01-01

    ... jurisdiction regarding criminal violations of law. [68 FR 35281, June 13, 2003] ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Expedited internal review process. 287.10... OFFICERS; POWERS AND DUTIES § 287.10 Expedited internal review process. (a) Violations of standards for...

  14. 75 FR 49938 - Proposed Collection; Comment Request; NIH NCI Central Institutional Review Board (CIRB...

    Science.gov (United States)

    2010-08-16

    .... Frequency of Response: Once, except for the SAE Reviewer Worksheet. Affected Public: Includes the Federal...). Board Members CIRB SAE Reviewer Worksheet 10 15 30/60 (.5 hour) 75 (Attachment 6K). Total 2221 Request..., National Institutes of Health. [FR Doc. 2010-20167 Filed 8-13-10; 8:45 am] BILLING CODE 4140-01-P ...

  15. LONG-RUN OPERATING PERFORMANCE OF PREFERRED STOCK ISSUERS

    OpenAIRE

    Devrim Yaman

    2011-01-01

    In this paper, we study the long-run operating performance of preferred stock issuers. We use three different measures of operating performance; pre-tax cash flows, profit margin and return on assets. We study the performance of industrial firms, financial firms, and utilities separately, as well as the performance of the whole sample. Our results indicate that the operating performance of preferred stock issuers as a whole declines in the three-years before the issue. We find that profitabil...

  16. 76 FR 65653 - New Source Performance Standards (NSPS) Review

    Science.gov (United States)

    2011-10-24

    ... current within their review cycle, there are also multiple standards in different phases of the review... Rock Plants NN 04/16/1982 (47FR16589) 10/17/2000 3 4 (65FR61760) Polymeric Coating of Supporting VVV 09... whether review of a particular NSPS is necessary during the review cycle. A listing of any NSPS for which...

  17. Effect of III-nitride polarization on V{sub OC} in p-i-n and MQW solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Namkoong, Gon; Boland, Patrick; Foe, Kurniawan; Latimer, Kevin [Department of Electrical and Computer Engineering, Old Dominion University, Applied Research Center, 12050 Jefferson Avenue, Newport News, VA 23606 (United States); Bae, Si-Young; Shim, Jae-Phil; Lee, Dong-Seon [School of Information and Communications, Gwangju Institute of Science and Technology, 261 Cheomdan-gwagiro (Oryong-dong), Buk-gu, Gwangju 500-712 (Korea, Republic of); Jeon, Seong-Ran [Korea Photonics Technology Institute, 971-35, Wolchul-dong, Buk-gu, Gwangju, 500-779 (Korea, Republic of); Doolittle, W. Alan [School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332 (United States)

    2011-02-15

    We performed detailed studies of the effect of polarization on III-nitride solar cells. Spontaneous and piezoelectric polarizations were assessed to determine their impacts upon the open circuit voltages (V{sub OC}) in p-i(InGaN)-n and multi-quantum well (MQW) solar cells. We found that the spontaneous polarization in Ga-polar p-i-n solar cells strongly modifies energy band structures and corresponding electric fields in a way that degrades V{sub OC} compared to non-polar p-i-n structures. In contrast, we found that piezoelectric polarization in Ga-polar MQW structures does not have a large influence on V{sub OC} compared to non-polar MQW structures. (copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  18. 12 CFR 7.1011 - National bank acting as payroll issuer.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false National bank acting as payroll issuer. 7.1011... AND OPERATIONS Bank Powers § 7.1011 National bank acting as payroll issuer. A national bank may disburse to an employee of a customer payroll funds deposited with the bank by that customer. The bank may...

  19. 75 FR 64403 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-10-19

    ... trustees and issuers to report contributions to, and the fair market value of, an individual retirement.... Type of Review: Extension without change to a currently approved collection. Title: Form 1099-INT...

  20. 17 CFR 249.250 - Form F-X, for appointment of agent for service of process by issuers registering securities on...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form F-X, for appointment of agent for service of process by issuers registering securities on Form F-8, F-9, F-10 or F-80 (§ 239.38... F-X, for appointment of agent for service of process by issuers registering securities on Form F-8...

  1. 17 CFR 260.0-11 - Liability for certain statements by issuers.

    Science.gov (United States)

    2010-04-01

    ... future economic performance contained in management's discussion and analysis of financial condition and... statements by issuers. 260.0-11 Section 260.0-11 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... § 260.0-11 Liability for certain statements by issuers. (a) A statement within the coverage of paragraph...

  2. 19 CFR 19.10 - Examination packages.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Examination packages. 19.10 Section 19.10 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... Examination packages. Merchandise sent from a bonded warehouse to the appraiser's stores for examination shall...

  3. 26 CFR 1.148-8 - Small issuer exception to rebate requirement.

    Science.gov (United States)

    2010-04-01

    ... present value. (d) Pooled financings—(1) Treatment of pool issuer. To the extent that an issuer of a... limitations, such as voter approval requirements, but may not be contingent on approval by another governmental unit. See, also, section 148(f)(4)(D)(iv). (c) Size limitation—(1) In general. An issue (other...

  4. 17 CFR 269.5 - Form F-X, for appointment of agent for service of process by issuers registering securities on...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form F-X, for appointment of agent for service of process by issuers registering securities on Form F-8, F-9, F-10 or F-80 (§§ 239... INDENTURE ACT OF 1939 § 269.5 Form F-X, for appointment of agent for service of process by issuers...

  5. OCS in He droplets

    Energy Technology Data Exchange (ETDEWEB)

    Grebenev, V.

    2000-06-01

    Phenomenon of superfluidity of para-hydrogen (pH{sub 2}){sub 1-17} and helium {sup 4}He{sub 1-7000} systems doped with an OCS chromophore molecule was investigated in this work. The study of such systems became possible after the development of the depletion spectroscopy technique in helium droplets. The droplets can be easily created and doped with up to 100 particles such as OCS, para-hydrogen or ortho-hydrogen molecules and {sup 4}He atoms. The measured infrared depletion spectra give the information about the temperature of the droplets and their aggregate state. The depletion spectrum of OCS in pure {sup 4}He droplets was comprehensively studied. The rovibrational OCS spectrum shows well resolved narrow lines. The spectrum is shifted to the red relative to the corresponding gas phase spectrum and the rotational constant of OCS in {sup 4}He droplet is three times smaller than that for free molecule. Different models of OCS rotation in the helium environment were discussed. It was shown that the shapes of the rovibrational lines are defined mainly by inhomogeneous broadening due to the droplet size distribution. The sub-rotational structure of the OCS rovibrational lines was revealed in microwave-infrared double resonance experiments. This structure arises due to the interaction of the OCS with the He environment. However, the information obtained in the experiments was not enough to understand the nature of this interaction. (orig.)

  6. Sm{sub 0.5}Sr{sub 0.5}CoO{sub 3}+Sm{sub 0.2}Ce{sub 0.8}O{sub 1.9} composite cathode for cermet supported thin Sm{sub 0.2}Ce{sub 0.8}O{sub 1.9} electrolyte SOFC operating below 600{sup o}C

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xinge; Robertson, Mark; Yick, Sing; Deces-Petit, Cyrille; Styles, Edward; Qu, Wei; Xie, Yongsong; Hui, Rob; Roller, Justin; Kesler, Olivera; Maric, Radenka; Ghosh, Dave [Institute for Fuel Cell Innovation, National Research Council Canada, 3250 East Mall, Vancouver, BC (Canada V6T 1W5)

    2006-10-06

    The cathode is a key component in low temperature solid oxide fuel cells. In this study, composite cathode, 75wt.% Sm{sub 0.5}Sr{sub 0.5}CoO{sub 3} (SSC)+25wt.% Sm{sub 0.2}Ce{sub 0.8}O{sub 1.9} (SDC), was applied on the cermet supported thin SDC electrolyte cell which was fabricated by tape casting, screen-printing, and co-firing. Single cells with the composite cathodes sintered at different temperatures were tested from 400 to 650{sup o}C. The best cell performance, 0.75Wcm{sup -2} peak power operating at 600{sup o}C, was obtained from the 1050{sup o}C sintered cathode. The measured thin SDC electrolyte resistance R{sub s} was 0.128{omega}cm{sup 2} and total electrode polarization R{sub p}(a+c) was only 0.102{omega}cm{sup 2} at 600{sup o}C. (author)

  7. 75 FR 27141 - Group Health Plans and Health Insurance Issuers Providing Dependent Coverage of Children to Age...

    Science.gov (United States)

    2010-05-13

    ... Group Health Plans and Health Insurance Issuers Providing Dependent Coverage of Children to Age 26 Under... Information and Insurance Oversight of the U.S. Department of Health and Human Services are issuing substantially similar interim final regulations with respect to group health plans and health insurance coverage...

  8. 75 FR 41787 - Requirement for Group Health Plans and Health Insurance Issuers To Provide Coverage of Preventive...

    Science.gov (United States)

    2010-07-19

    ... Requirement for Group Health Plans and Health Insurance Issuers To Provide Coverage of Preventive Services... Insurance Oversight of the U.S. Department of Health and Human Services are issuing substantially similar interim final regulations with respect to group health plans and health insurance coverage offered in...

  9. 77 FR 8725 - Group Health Plans and Health Insurance Issuers Relating to Coverage of Preventive Services Under...

    Science.gov (United States)

    2012-02-15

    ... regulations authorizing the exemption of group health plans and group health insurance coverage sponsored by... plans and group health insurance issuers on April 16, 2012. FOR FURTHER INFORMATION CONTACT: Amy Turner... addition, information from HHS on private health insurance for consumers can be found on the CMS Web site...

  10. 75 FR 43109 - Requirements for Group Health Plans and Health Insurance Issuers Relating to Internal Claims and...

    Science.gov (United States)

    2010-07-23

    ... Requirements for Group Health Plans and Health Insurance Issuers Relating to Internal Claims and Appeals and... the Office of Consumer Information and Insurance Oversight of the U.S. Department of Health and Human... health insurance coverage offered in connection with a group health plan under the Employee Retirement...

  11. Impact of cytochrome P450 2C19 polymorphisms on citalopram/escitalopram exposure: a systematic review and meta-analysis.

    Science.gov (United States)

    Chang, Ming; Tybring, Gunnel; Dahl, Marja-Liisa; Lindh, Jonatan D

    2014-09-01

    Citalopram and escitalopram, selective serotonin reuptake inhibitors, are primarily metabolized by cytochrome P450 (CYP) 2C19, which is a highly polymorphic enzyme known to cause inter-individual differences in pharmacokinetics. However, the impact of CYP2C19 polymorphisms on citalopram or escitalopram exposure has yet to be fully clarified, especially with regard to the quantitative impact of the CYP2C19*17 allele. The objective of this study was to quantify the effect of functional CYP2C19 allele variants on citalopram/escitalopram exposure. We performed a systematic review and meta-analysis with a structured search algorithm and eligibility criteria for including related studies, calculating the change of citalopram or escitalopram exposure associated with CYP2C19*2, *3, and *17 as compared with CYP2C19*1 using fixed-effect and random-effects models. Assessment of publication bias was performed by means of funnel plots and sensitivity analysis using meta-regressions. The pre-defined review protocol was registered at the PROSPERO international prospective register of systematic reviews, registration number CRD42013004106. Sixteen studies from 14 publications met the inclusion criteria. Eligible studies included 847 patients from psychiatric patient trials and 140 healthy subjects from pharmacokinetic studies. Compared to subjects with the EM/EM (CYP2C19*1/*1) genotype, the exposure to (es)citalopram increased by 95 % (95 % CI 40-149, p escitalopram. All functional CYP2C19 genotype groups demonstrated significant effects on (es)citalopram exposure. The findings based on our pooled analysis are likely to help in understanding the inter-individual variability in the exposure to citalopram and escitalopram in psychiatric patients and to facilitate dose selection, particularly for the homozygous carriers of CYP2C19*2 or *3 (loss of function) and CYP2C19*17 (gain of function) alleles. The results could improve individualization of citalopram or escitalopram therapy

  12. 17 CFR 210.6-06 - Special provisions applicable to the balance sheets of issuers of face-amount certificates.

    Science.gov (United States)

    2010-04-01

    ... to the balance sheets of issuers of face-amount certificates. 210.6-06 Section 210.6-06 Commodity and... balance sheets of issuers of face-amount certificates. Balance sheets filed by issuers of face-amount... forth separately, in the balance sheet or in a note thereto, for accounts receivable and notes...

  13. 75 FR 26757 - National Toxicology Program (NTP); Office of Liaison, Policy and Review; Meeting of the...

    Science.gov (United States)

    2010-05-12

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Toxicology Program (NTP); Office of Liaison, Policy and Review; Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods... Director, National Toxicology Program. [FR Doc. 2010-11318 Filed 5-11-10; 8:45 am] BILLING CODE 4140-01-P ...

  14. 13 CFR 107.1820 - Conditions affecting issuers of Preferred Securities and/or Participating Securities.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Conditions affecting issuers of... Terms of Leverage § 107.1820 Conditions affecting issuers of Preferred Securities and/or Participating... investor. (6) Fraudulent transfers. You make any transfer or incur any obligation that is fraudulent under...

  15. Vibrational relaxation in OCS mixtures

    International Nuclear Information System (INIS)

    Simpson, C.J.S.M.; Gait, P.D.; Simmie, J.M.

    1976-01-01

    Experimental measurements are reported of vibrational relaxation times which may be used to show whether there is near resonant vibration-rotation energy transfer between OCS and H 2 , D 2 or HD. Vibrational relaxation times have been measured in OCS and OCS mixtures over the temperature range 360 to 1000 K using a shock tube and a laser schlieren system. The effectiveness of the additives in reducing the relaxation time of OCS is in the order 4 He 3 He 2 2 and HD. Along this series the effect of an increase in temperature changes from the case of speeding up the rate with 4 He to retarding it with D 2 , HD and H 2 . There is no measurable difference in the effectiveness of n-D 2 and o-D 2 and little, or no, difference between n-H 2 and p-H 2 . Thus the experimental results do not give clear evidence for rotational-vibration energy transfer between hydrogen and OCS. This contrasts with the situation for CO 2 + H 2 mixtures. (author)

  16. Study of 19F and 19Ne mirror nuclei

    International Nuclear Information System (INIS)

    Lebrun, Claude.

    1976-01-01

    The electromagnetic properties of the mirror nuclei 19 F and 19 Ne were studied using the 18 O(d,nγ) 19 F, 17 O( 3 He,nγ) 19 Ne and 19 F(p,nγ) 19 Ne reactions. Lifetimes of 8 levels in 19 F and 11 levels in 19 Ne have been measured using the Doppler shift attenuation method. Weak and strong components of M 1 , E 1 and E 2 transition strengths are compared with shell model predictions. M 1 and E 2 transition strengths of conjugated nuclei (A=18 to A=34) are compiled and compared with wide configuration space shell models [fr

  17. 24 CFR 320.3 - Eligible issuers of securities.

    Science.gov (United States)

    2010-04-01

    ...) Have management with adequate experience, and access to adequate facilities to issue or service... policies of the issuer permit any discrimination based on race, religion, color, national origin, age, or... its business operations in accordance with accepted mortgage banking practices, ethics, and standards...

  18. Menstrual cyclicity post OC withdrawal in PCOS: Use of non-hormonal options.

    Science.gov (United States)

    Kulshreshtha, Bindu; Arora, Arpita; Pahuja, Isha; Sharma, Neera; Pant, Shubhi

    2016-08-01

    There is no data on menstrual cyclicity post oral contraceptive (OC) withdrawal with nonhormonal options in PCOS patients. OC could affect obesity, insulin and gonadotropins factors integral to pathogenesis of PCOS, thereby adversely affecting the HPG axis. Menstrual cycles of PCOS patients were retrospectively studied post OCP. Patients developing regular versus irregular cycles post OC were compared. Forty-eight PCOS patients were followed for an average of 1.9 years post OC. Thirty-six (75%) achieved regular cycles over a period of one year with other nonhormonal options like spironolactone and metformin. Seven patients required no treatment. Patients who continued to have irregular cycles had a longer pre OC cycle length (p PCOS may not require any treatment post OC.

  19. 7 CFR 250.19 - Reviews.

    Science.gov (United States)

    2010-01-01

    ... or review to determine the extent to which sales are to be disallowed, establish a claim, and/or... 7 Agriculture 4 2010-01-01 2010-01-01 false Reviews. 250.19 Section 250.19 Agriculture Regulations... TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General Operating Provisions § 250.19 Reviews. (a...

  20. The interaction of soil phototrophs and fungi with pH and their impact on soil CO2, CO18O and OCS exchange.

    Science.gov (United States)

    Sauze, Joana; Ogée, Jérôme; Maron, Pierre-Alain; Crouzet, Olivier; Nowak, Virginie; Wohl, Steven; Kaisermann, Aurore; Jones, Sam P; Wingate, Lisa

    2017-12-01

    The stable oxygen isotope composition of atmospheric CO 2 and the mixing ratio of carbonyl sulphide (OCS) are potential tracers of biospheric CO 2 fluxes at large scales. However, the use of these tracers hinges on our ability to understand and better predict the activity of the enzyme carbonic anhydrase (CA) in different soil microbial groups, including phototrophs. Because different classes of the CA family (α, β and γ) may have different affinities to CO 2 and OCS and their expression should also vary between different microbial groups, differences in the community structure could impact the 'community-integrated' CA activity differently for CO 2 and OCS. Four soils of different pH were incubated in the dark or with a diurnal cycle for forty days to vary the abundance of native phototrophs. Fluxes of CO 2 , CO 18 O and OCS were measured to estimate CA activity alongside the abundance of bacteria, fungi and phototrophs. The abundance of soil phototrophs increased most at higher soil pH. In the light, the strength of the soil CO 2 sink and the CA-driven CO 2 -H 2 O isotopic exchange rates correlated with phototrophs abundance. OCS uptake rates were attributed to fungi whose abundance was positively enhanced in alkaline soils but only in the presence of increased phototrophs. Our findings demonstrate that soil-atmosphere CO 2 , OCS and CO 18 O fluxes are strongly regulated by the microbial community structure in response to changes in soil pH and light availability and supports the idea that different members of the microbial community express different classes of CA, with different affinities to CO 2 and OCS.

  1. 12 CFR 335.221 - Forms for registration of securities; optional forms for small business issuers; and...

    Science.gov (United States)

    2010-01-01

    ... forms for small business issuers; and incorporation of Regulation FD (Fair Disclosure). 335.221 Section... forms for small business issuers; and incorporation of Regulation FD (Fair Disclosure). (a) The.... Industry Guide 3, Statistical Disclosure by Bank Holding Companies, is codified at 17 CFR 229.802. (c) A...

  2. 78 FR 12318 - Federal Acquisition Regulation; Submission for OMB Review; Economic Price Adjustment

    Science.gov (United States)

    2013-02-22

    ...; Submission for OMB Review; Economic Price Adjustment AGENCY: Department of Defense (DOD), General Services... economic price adjustment. A notice was published in the Federal Register at 77 FR 69442, on November 19...: Submit comments identified by Information Collection 9000- 0068, Economic Price Adjustment by any of the...

  3. Investigation of amorphous RuMoC alloy films as a seedless diffusion barrier for Cu/p-SiOC:H ultralow-k dielectric integration

    Energy Technology Data Exchange (ETDEWEB)

    Jiao, Guohua [Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen (China); The Chinese University of Hong Kong, Shatin, Hong Kong (China); Liu, Bo [Sichuan University, Key Laboratory of Radiation Physics and Technology of Ministry of Education, Institute of Nuclear Science and Technology, Chengdu (China); Li, Qiran [CNRS-Universite Paris Sud UMR 8622, Institut d' Electronique Fondamentale, Orsay (France)

    2015-08-15

    Ultrathin RuMoC amorphous films prepared by magnetron co-sputtering with Ru and MoC targets in a sandwiched scheme Si/p-SiOC:H/RuMoC/Cu were investigated as barrier in copper metallization. The evolution of final microstructure of RuMoC alloy films show sensitive correlation with the content of doped Mo and C elements and can be easily controlled by adjusting the sputtering power of the MoC target. There was no signal of interdiffusion between the Cu and SiOC:H layer in the sample of Cu/RuMoC/p-SiOC:H/Si, even annealing up to 500 C. Very weak signal of oxygen have been confirmed in the RuMoC barrier layer both as-deposited and after being annealed, and a good performance on preventing oxygen diffusion has been proved. Leakage current and resistivity evaluations also reveal the excellent thermal reliability of this Si/p-SiOC:H/RuMoC/Cu film stack at the temperatures up to 500 C, indicating its potential application in the advanced barrierless Cu metallization. (orig.)

  4. 75 FR 38111 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-07-01

    ... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; PAR10-082: Mass Spectrometry Instrumentation. Date: July 19-20, 2010. Time: 8 a.m. to 6 p.m. Agenda: To review and evaluate... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

  5. 78 FR 42969 - Center For Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-07-18

    ... Instrumentation: PET/CT/SPECT. Date: August 6, 2013. Time: 12:00 p.m. to 5:00 p.m. Agenda: To review and evaluate... A. Baum, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2013-17190 Filed 7...

  6. 17 CFR 240.3a4-1 - Associated persons of an issuer deemed not to be brokers.

    Science.gov (United States)

    2010-04-01

    ... compensated in connection with his participation by the payment of commissions or other remuneration based... communication is approved by a partner, officer or director of the issuer; (B) Responding to inquiries of a... who is a partner, officer, director, or employee of: (i) The issuer; (ii) A corporate general partner...

  7. 76 FR 38431 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-06-30

    ... Commission's minimum performance standards regarding registered transfer agents, and (2) to assure that issuers are aware of certain problems and poor performances with respect to the transfer agents that are... failure to comply with the Commission's minimum performance standards then the issuer will be unable to...

  8. Undervattensfotografering : Vattnets påverkan på ljus

    OpenAIRE

    Lönnström, Mathias

    2011-01-01

    Syftet med detta arbete var att jag skulle fördjupa mig i undervattensfotografering och diskutera skillnaderna mellan att fotografera i luft från att fotografera i vatten. Jag ville i och med min forskning bygga upp en kunskapsbank åt mig själv inför kommande projekt. Detta åstadkom jag genom att först studera teorin i böcker av Martin Edge och Blain Brown och på så sätt förbereda mig inför de praktiska fotograferingssessionerna jag senare utförde. Efteråt analyserade jag mina erfarenheter oc...

  9. Field measurement on the emissions of PM, OC, EC and PAHs from indoor crop straw burning in rural China

    International Nuclear Information System (INIS)

    Wei, Siye; Shen, Guofeng; Zhang, Yanyan; Xue, Miao; Xie, Han; Lin, Pengchuan; Chen, Yuanchen; Wang, Xilong; Tao, Shu

    2014-01-01

    Field measurements were conducted to measure emission factors of particulate matter (EF PM ), organic carbon (EF OC ), elemental carbon (EF EC ), 28 parent polycyclic aromatic hydrocarbons (EF 28pPAHs ), and 4 oxygenated PAHs (EF 4oPAHs ) for four types of crop straws burned in two stoves with similar structure but different ages. The average EF PM , EF OC , EF EC , EF 28pPAHs , and EF 4oPAHs were 9.1 ± 5.7 (1.8–22 as range), 2.6 ± 2.9 (0.30–12), 1.1 ± 1.2 (0.086–5.5), 0.26 ± 0.19 (0.076–0.96), 0.011 ± 0.14 (1.3 × 10 −4 – 0.063) g/kg, respectively. Much high EF 28pPAHs was observed in field compared with the laboratory derived EFs and significant difference in EF 28pPAHs was identified among different crop residues, indicating considerable underestimation when laboratory derived EFs were used in the inventory. The field measured EF PM , EF OC , and EF EC were significantly affected by stove age and the EFs of carbonaceous particles for the 15-year old stove were approximately 2.5 times of those for the 1-year old stove. Highlights: • Field measurements provided more reliable data for the inventory. • Emissions from indoor crop residue burning were measured in field. • Much high PAHs emissions were found in field measurement in comparison with laboratory derived results. • Emissions of carbonaceous particulate matter increased by 2.5 times in the old stove compared that in a new stove. -- Emissions of incomplete combustion pollutants strongly affected by the fuel type and stove usage

  10. 10 CFR 440.19 - Labor.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Labor. 440.19 Section 440.19 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION WEATHERIZATION ASSISTANCE FOR LOW-INCOME PERSONS § 440.19 Labor. Payments for labor... supplement wages paid to training participants, public service employment workers, or other Federal or State...

  11. Joint bidding restriction policy for selective E and P firms in the US Gulf of Mexico OCS: How persuasive is its effectiveness?

    International Nuclear Information System (INIS)

    Iledare, Omowumi O.; Pulsipher, Allan G.

    2007-01-01

    The principal Minerals Management Service (MMS) policy or regulation intended to promote competition (or inhibit collusion) in the lease market is the Restricted Joint Bidders List. It is compiled and published twice a year and applies to all lease sales held during the subsequent six-month period or until the next list is issued. This paper applies descriptive and econometric analyses to data on lease sales in the US Gulf of Mexico OCS region to evaluate the effectiveness of this policy. In the aggregate, empirical analyses suggest that the imposition of joint bid restrictions on some E and P firms reduces bidding effectiveness for petroleum leases on the OCS. The patterns of bidding for leases on the OCS by E and P firms restricted from bidding jointly do not seem to indicate anticompetitive behavior. Further, joint bidding is found to be consistently associated with higher average high bids and this seems to be consistent with, and perhaps enhances competition in the lease market

  12. 78 FR 54069 - Patient Protection and Affordable Care Act; Program Integrity: Exchange, SHOP, and Eligibility...

    Science.gov (United States)

    2013-08-30

    ... Qualified Health Plans; Exchange Standards for Employers, 77 FR 18310 (March 27, 2012). \\2\\ Patient..., including States, health insurance issuers, consumer groups, agents and brokers, provider groups, Members of....120(c) to Exchange consumer assistance entities, please see the recent final rule, Patient Protection...

  13. 19p13.1 is a triple-negative-specific breast cancer susceptibility locus

    DEFF Research Database (Denmark)

    Stevens, Kristen N; Fredericksen, Zachary; Vachon, Celine M

    2012-01-01

    (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly......The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with the risk of ovarian cancer. Here, we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor...... associated with ER-negative breast cancer risk [rs8170 OR, 1.10; 95% confidence interval (CI), 1.05-1.15; P = 3.49 × 10(-5)] and triple-negative (ER-, PR-, and HER2-negative) breast cancer (rs8170: OR, 1.22; 95% CI, 1.13-1.31; P = 2.22 × 10(-7)). However, rs8170 was no longer associated with ER...

  14. 76 FR 63312 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-10-12

    ...: Lawrence E Boerboom, PhD, Chief, CVRS IRG, Center for Scientific Review, National Institutes of Health.... Jennifer S. Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 2011-26355 Filed 10-11...

  15. Fugitive hydrocarbon emissions from pacific OCS facilities. Volume 1. Final report

    International Nuclear Information System (INIS)

    1992-01-01

    In January 1989, the Minerals Management Service (MMS) conducted a study using the latest approved methods for emission screening and sampling solely on Outer Continental Shelf (OCS) oil and gas platforms in the Santa Barbara Channel in order to determine platform emission rates more representative of that region. The study was designed and reviewed throughout its conduct by a Quality Review Board (QRB) composed of air resource agencies and industry. Representatives from the Tri-county Air Pollution Control Districts and the MMS actively participated at these meetings. Some participants expressed concerns about some of the methods used and the study results. ABB's thorough responses to these questions and comments were submitted to all reviewers before the printing of the final report, and are contained in appendices of the study final report now available to the public. The results of the MMS study show that the average emission factors for the Pacific OCS oil and gas facilities measured in 1989 are 3.5 times lower than those Pacific OCS facilities sampled in the 1979 API/Rockwell study, and 7.8 times lower than the Gulf of Mexico OCS facilities sampled in the same 1979 study. Efforts to determine the quantitative effect of inspection and maintenance programs on controlling emissions were inconclusive

  16. On the differences between 1.5oC and 2oC of global warming

    Science.gov (United States)

    King, A.

    2017-12-01

    The Paris Agreement of 2015 has resulted in a drive to limit global warming to 2oC with an aim for a lower 1.5oC target. It is therefore vital that we understand some of the differences we would expect between these two levels of global warming. My research uses coupled climate model projections to investigate where and for what variables we can differentiate between worlds of 1.5oC and 2oC global warming. I place a particular focus on climate extremes and population exposure to those extremes. I have found that there are perceptible benefits in limiting global warming to 1.5oC as opposed to 2oC through reduced frequency and intensity of heat extremes, both over land and in ocean areas where thermal stress on coral has resulted in bleaching. Differences in high and low precipitation extremes between the 1.5oC and 2oC global warming levels are projected for some regions. I have also examined how "scalable" changes from the 1.5oC to 2oC level are. In areas of the world such as Eastern China I find that changes in anthropogenic aerosol concentrations will influence the level of change projected at 1.5oC and 2oC, such that past warming is likely to be a poor indicator of future changes. Overall, my research finds clear benefits to limiting global warming to 1.5oC relative to higher levels.

  17. Clinical comparison of overlapping deletions of 19p13.3.

    Science.gov (United States)

    Risheg, Hiba; Pasion, Romela; Sacharow, Stephanie; Proud, Virginia; Immken, LaDonna; Schwartz, Stuart; Tepperberg, Jim H; Papenhausen, Peter; Tan, Tiong Y; Andrieux, Joris; Plessis, Ghislaine; Amor, David J; Keitges, Elisabeth A

    2013-05-01

    We present three patients with overlapping interstitial deletions of 19p13.3 identified by high resolution SNP microarray analysis. All three had a similar phenotype characterized by intellectual disability or developmental delay, structural heart abnormalities, large head relative to height and weight or macrocephaly, and minor facial anomalies. Deletion sizes ranged from 792 Kb to 1.0 Mb and included a common region arr [hg19] 19p13.3 (3,814,392-4,136,989), containing eight genes: ZFR2, ATCAY, NMRK2, DAPK3, EEF2, PIAS4, ZBTB7A, MAP2K2, and two non-coding RNA's MIR637 and SNORDU37. The patient phenotypes were compared with three previous single patient reports with similar interstitial 19p13.3 deletions and six additional patients from the DECIPHER and ISCA databases to determine if a common haploinsufficient phenotype for the region can be established. Copyright © 2013 Wiley Periodicals, Inc.

  18. 12 CFR 19.10 - Filing of papers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Filing of papers. 19.10 Section 19.10 Banks and... Rules of Practice and Procedure § 19.10 Filing of papers. (a) Filing. Any papers required to be filed...) Delivering the papers to a reliable commercial courier service, overnight delivery service, or to the U.S...

  19. Why do convertible issuers simultaneously repurchase stock? An arbitrage-based explanation

    NARCIS (Netherlands)

    de Jong, Abe; Dutordoir, Marie; Verwijmeren, Patrick

    Over recent years, a substantial fraction of US convertible bond issues have been combined with a stock repurchase. This paper explores the motivations for these combined transactions. We argue that convertible debt issuers repurchase their stock to facilitate arbitrage-related short selling. In

  20. 75 FR 68385 - Senior Executive Service-Performance Review Board

    Science.gov (United States)

    2010-11-05

    ... OPM Performance Review Board. FOR FURTHER INFORMATION CONTACT: Tammy Van Keuren, OPM Human Resources, Recruitment and Staffing, Office of Personnel Management, 1900 E Street NW., Washington, DC 20415, (202) 606... Associate Director for Human Resources--Executive Secretariat. [FR Doc. 2010-28171 Filed 11-4-10; 8:45 am...

  1. File list: InP.Adp.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Adp.10.Input_control.AllCell hg19 Input control Input control Adipocyte SRX0194...p://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Adp.10.Input_control.AllCell.bed ...

  2. 77 FR 62150 - Approval and Promulgation of Implementation Plans; Kentucky; Approval of Revisions to the...

    Science.gov (United States)

    2012-10-12

    ....34 Standard of 10/23/01 66 FR 53661 05/15/91 Performance for Existing Pneumatic Rubber Tire... Abbreviations and 11/19/02 67 FR 69688 05/15/02 Acronyms. 1.04 Performance Tests... 10/23/01 66 FR 53660 11/19... 10/23/01 66 FR 53660 06/13/79 Requirements. Reg 6--Standards of Performance for Existing Affected...

  3. File list: InP.Gon.10.AllAg.Testis [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Gon.10.AllAg.Testis hg19 Input control Gonad Testis SRX663452,SRX663439,SRX6634...45,SRX663442 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Gon.10.AllAg.Testis.bed ...

  4. Radiocarbon analysis of BC and OC in PM10 aerosols at Cape Hedo, Okinawa, Japan, during long-range transport events from East Asian countries

    International Nuclear Information System (INIS)

    Handa, Daishi; Nakajima, Hitomi; Arakaki, Takemitsu; Kumata, Hidetoshi; Shibata, Yasuyuki; Uchida, Masao

    2010-01-01

    We determined the 14 C/ 12 C ratio and concentrations of black carbon (BC) and organic carbon (OC) in airborne particulate matter (APM) with diameter 10 ) collected in Okinawa, Japan, between March and June 2008. During Asian dust events in March and April, APM and OC concentrations in PM 10 aerosols were approximately threefold and twofold higher than those during the non-Asian-dust period in June. 'Refractory' BC concentrations (i.e., because of refraction, 10 aerosols collected during the Asian dust events (mean = 41.5% and 62.3%, respectively) than for those collected in the non-Asian-dust period (mean = 67.2% and 93.8%, respectively), indicating a strong influence of fossil-fuel-derived carbon during Asian dust events. One sample showed high OC concentration but relatively low BC concentration, suggesting formation during the long-range transport of biogenic organic compounds. The results suggest that not only fossil-fuel-derived air pollutants but also organic compounds derived from biomass in Asia should be considered to better characterize long-range transported aerosols.

  5. 78 FR 64512 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-10-29

    ... Biology. Date: November 19, 2013. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant... Research in Diabetes, Obesity and Endocrine Disorders. Date: November 19, 2013. Time: 8:00 a.m. to 8:00 p.m... Scientific Review Special Emphasis Panel; Molecular Neuroscience. Date: November 19, 2013. Time: 1:00 p.m. to...

  6. Genetically heterogeneous glioblastoma recurring with disappearance of 1p/19q losses: case report.

    Science.gov (United States)

    Ito, Motokazu; Wakabayashi, Toshihiko; Natsume, Atsushi; Hatano, Hisashi; Fujii, Masazumi; Yoshida, Jun

    2007-07-01

    Intratumor heterogeneity is of great importance in many clinical aspects of glioma biology, including tumor grading, therapeutic response, and recurrence. Modifications in the genetic features of a specific primary tumor recurring after chemo- and radiotherapy are poorly understood. We report a recurrent glioblastoma case exhibiting loss of heterozygosity (LOH) on chromosome 10q, while the primary tumor exhibited heterogeneity in the LOH status of 1p, 19q, and 10q. To determine the relationship between such modifications and heterogeneous chemosensitivity, primary cultured cells heterogeneously showing 1p/19q/10q losses were established from a surgical specimen of oligoastrocytoma and were treated with chemotherapeutic agents. A 46-year-old woman with a 1-month history of headache and visual disturbances presented to our institution. A right temporoparietal craniotomy and gross total resection were performed. The pathological diagnosis was glioblastoma multiforme with oligodendroglial components. Whereas LOH on 10q was identified at all tumor sites, only the oligodendroglial components exhibited LOH on 1p and 19q. The tumor recurred 6 months after postoperative chemotherapy using interferon-beta and ranimustine, as well as a course of fractionated external-beam radiotherapy (total dose, 60 Gy). Gene analysis revealed no 1p/19q allelic losses but only 10q LOH. Intratumor heterogeneity might be explained by the presence of more than one subclone in the primary tumor. Here, the tumor cells exhibiting 1p/19q LOH with high chemosensitivity might have been killed by the adjuvant therapy and those exhibiting 10q LOH with chemoresistance recurred. This study and our preliminary laboratory findings might suggest an approach to brain tumor physiology, diagnosis, and therapy.

  7. 78 FR 21457 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-04-10

    ... an orderly way with issuers during periods of market stress. \\4\\ See Securities Exchange Act Release... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-69295; File No. SR-NYSE-2013-27] Self... Exchange Act Release No. 67091 (May 31, 2012), 77 FR 33498 (June 6, 2012) (``LULD Release''). Nevertheless...

  8. File list: InP.Bld.10.AllAg.PBMC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Bld.10.AllAg.PBMC hg19 Input control Blood PBMC SRX151954,SRX099233,SRX099232,S...RX095365,SRX037434 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Bld.10.AllAg.PBMC.bed ...

  9. File list: InP.Oth.10.AllAg.Fibrosarcoma [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Oth.10.AllAg.Fibrosarcoma hg19 Input control Others Fibrosarcoma SRX253236,SRX2...53233,SRX253238,SRX253237,SRX253234,SRX253235 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Oth.10.AllAg.Fibrosarcoma.bed ...

  10. 19 CFR 354.10 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery. 354.10 Section 354.10 Customs Duties... ANTIDUMPING OR COUNTERVAILING DUTY ADMINISTRATIVE PROTECTIVE ORDER § 354.10 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery procedures regarding any matter, not...

  11. File list: InP.Bld.10.AllAg.Polymorphonuclear_leukocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Bld.10.AllAg.Polymorphonuclear_leukocytes hg19 Input control Blood Polymorphonuclear... leukocytes http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Bld.10.AllAg.Polymorphonuclear_leukocytes.bed ...

  12. 75 FR 64182 - Issuer Review of Assets in Offerings of Asset-Backed Securities

    Science.gov (United States)

    2010-10-19

    ... review your comments more efficiently, please use only one method. The Commission will post all comments... originated in compliance with applicable laws, including predatory lending and Truth in Lending statutes..., including predatory lending and Truth in Lending statutes? Should we establish standards for a review of the...

  13. 10 CFR 19.20 - Employee protection.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Employee protection. 19.20 Section 19.20 Energy NUCLEAR... Employee protection. Employment discrimination by a licensee, a holder of a certificate of compliance... as delineated in § 19.2(a), against an employee for engaging in protected activities under this part...

  14. File list: InP.CDV.10.AllAg.Endocardial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.CDV.10.AllAg.Endocardial_cells hg19 Input control Cardiovascular Endocardial ce...lls http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.CDV.10.AllAg.Endocardial_cells.bed ...

  15. OPTIMIZATION OF REACTIVE BLUE 19 DECOLORIZATION BY GANODERMA SP. USING RESPONSE SURFACE METHODOLOGY

    Directory of Open Access Journals (Sweden)

    1M. Mohammadian Fazli, *1A. R. Mesdaghinia, 1K. Naddafi, 1S. Nasseri , 1M. Yunesian, 2M. Mazaheri Assadi, 3S. Rezaie, 4H. Hamzehei

    2010-01-01

    Full Text Available Synthetic dyes are extensively used in different industries. Dyes have adverse impacts such as visual effects, chemical oxygen demand, toxicity, mutagenicity and carcinogenicity characteristics. White rot fungi, due to extracellular enzyme system, are capable to degrade dyes and various xenobiotics. The aim of this study was to optimize decolorization of reactive blue 19 (RB19 dye using Ganoderma sp. fungus. Response Surface Methodology (RSM was used to study the effect of independent variables, namely glycerol concentration (15, 20 and 25 g/L, temperature (27, 30 and 33 oC and pH (5.5, 6.0 and 6.5 on color removal efficiency in aqueous solution. From RSM-generated model, the optimum conditions for RB19 decolorization were identified to be at temperature of 27oC, glycerol concentration of 19.14 mg/L and pH=6.3. At the optimum conditions, predicted decolorization was 95.3 percent. The confirmatory experiments were conducted and confirmed the results by 94.89% color removal. Thus, this statistical approach enabled to improve reactive blue 19 decolorization process by Ganoderma sp. up to 1.27 times higher than non-optimized conditions.

  16. Unsichtbar. Meditation zum Lukasevangelium 19,1-10

    DEFF Research Database (Denmark)

    Nielsen, Kirsten Busch

    2008-01-01

    En meditation over Lukasevangeliet 19,1-10 (Zakæus) med temaet usynlighed som omdrejningspunkt. Udgivelsesdato: 2007......En meditation over Lukasevangeliet 19,1-10 (Zakæus) med temaet usynlighed som omdrejningspunkt. Udgivelsesdato: 2007...

  17. File list: InP.Dig.10.AllAg.Intestine,_Small [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Dig.10.AllAg.Intestine,_Small hg19 Input control Digestive tract Intestine, Sma...ll http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Dig.10.AllAg.Intestine,_Small.bed ...

  18. 10 CFR 19.32 - Discrimination prohibited.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Discrimination prohibited. 19.32 Section 19.32 Energy... § 19.32 Discrimination prohibited. No person shall on the grounds of sex be excluded from participation in, be denied a license, be denied the benefit of, or be subjected to discrimination under any...

  19. 19 CFR 151.10 - Sampling.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Sampling. 151.10 Section 151.10 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE General § 151.10 Sampling. When necessary, the port director...

  20. 17 CFR 210.3-20 - Currency for financial statements of foreign private issuers.

    Science.gov (United States)

    2010-04-01

    ... in the issuer's consolidated financial statements and not located in a hyperinflationary environment..., Oct. 5, 1999] Consolidated and Combined Financial Statements ... SECURITIES AND EXCHANGE COMMISSION FORM AND CONTENT OF AND REQUIREMENTS FOR FINANCIAL STATEMENTS, SECURITIES...

  1. File list: InP.Bld.10.AllAg.Plasma_Cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Bld.10.AllAg.Plasma_Cells hg19 Input control Blood Plasma Cells SRX203397,SRX20...3398 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Bld.10.AllAg.Plasma_Cells.bed ...

  2. File list: InP.Bld.10.AllAg.Dendritic_Cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  3. File list: InP.Neu.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  4. File list: InP.Bon.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  5. File list: InP.PSC.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.10.Input_control.AllCell hg19 Input control Input control Pluripotent stem ...RX342849,ERX342851 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.10.Input_control.AllCell.bed ...

  6. File list: InP.Myo.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Myo.10.Input_control.AllCell hg19 Input control Input control Muscle SRX018653,...652,SRX038601 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Myo.10.Input_control.AllCell.bed ...

  7. 12 CFR 19.41 - Stays pending judicial review.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Stays pending judicial review. 19.41 Section 19... PROCEDURE Uniform Rules of Practice and Procedure § 19.41 Stays pending judicial review. The commencement of... effectiveness of all or any part of an order pending a final decision on a petition for review of that order. ...

  8. 76 FR 63608 - Export Trade Certificate of Review

    Science.gov (United States)

    2011-10-13

    ... Economic Analysis (``OCEA'') of the International Trade Administration, Department of Commerce, has... Analysis, International Trade Administration, (202) 482-5131 (this is not a toll-free number) or e-mail at... Economic Analysis. [FR Doc. 2011-26502 Filed 10-12-11; 8:45 am] BILLING CODE 3510-DR-P ...

  9. File list: InP.Bld.10.AllAg.CCRF-CEM [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Bld.10.AllAg.CCRF-CEM hg19 Input control Blood CCRF-CEM SRX728791,SRX107305,SRX...107290 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Bld.10.AllAg.CCRF-CEM.bed ...

  10. File list: InP.Prs.10.AllAg.Prostate_cancer [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Prs.10.AllAg.Prostate_cancer hg19 Input control Prostate Prostate cancer SRX861...688,SRX861689,SRX861686 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Prs.10.AllAg.Prostate_cancer.bed ...

  11. File list: InP.Brs.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Brs.10.Input_control.AllCell hg19 Input control Input control Breast SRX386756,...2,ERX371677,SRX1272812 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Brs.10.Input_control.AllCell.bed ...

  12. File list: InP.CDV.10.AllAg.Carotid_Arteries [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.CDV.10.AllAg.Carotid_Arteries hg19 Input control Cardiovascular Carotid Arterie...s DRX021452,DRX021453,DRX021454 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.CDV.10.AllAg.Carotid_Arteries.bed ...

  13. File list: InP.Kid.10.AllAg.Nephrectomy_sample [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Kid.10.AllAg.Nephrectomy_sample hg19 Input control Kidney Nephrectomy sample SR...90,SRX1037589,SRX1037588,SRX1037582 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Kid.10.AllAg.Nephrectomy_sample.bed ...

  14. File list: InP.Dig.10.AllAg.Colon_cancer [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Dig.10.AllAg.Colon_cancer hg19 Input control Digestive tract Colon cancer SRX12...155774,SRX625671,SRX155777 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Dig.10.AllAg.Colon_cancer.bed ...

  15. 77 FR 76427 - Approval and Promulgation of Air Quality Implementation Plans; Wisconsin; Milwaukee-Racine...

    Science.gov (United States)

    2012-12-28

    ...-hour ozone), 75 FR 27944 (May 19, 2010) (Coso Junction, California, PM 10 ). EPA also incorporated its... regulatory action'' subject to review by the Office of Management and Budget under Executive Order 12866 (58... not an economically significant regulatory action based on health or safety risks subject to Executive...

  16. Tactile/kinesthetic stimulation (TKS) increases tibial speed of sound and urinary osteocalcin (U-MidOC and unOC) in premature infants (29-32weeks PMA).

    Science.gov (United States)

    Haley, S; Beachy, J; Ivaska, K K; Slater, H; Smith, S; Moyer-Mileur, L J

    2012-10-01

    Preterm delivery (kinesthetic stimulation (TKS), a form of infant massage that incorporates kinesthetic movement, would increase bone strength and markers of bone accretion in preterm infants. Preterm, AGA infants (29-32 weeks) were randomly assigned to TKS (N=20) or Control (N=20). Twice daily TKS was provided 6 days per week for 2 weeks. Control infants received the same care without TKS treatment. Treatment was masked to parents, health care providers, and study personnel. Baseline and week two measures were collected for tibial speed of sound (tSOS, m/sec), a surrogate for bone strength, by quantitative ultrasound (Sunlight8000) and urine markers of bone metabolism, pyridinium crosslinks and osteocalcin (U-MidOC and unOC). Infant characteristics at birth and study entry as well as energy/nutrient intake were similar between TKS and Control. TKS intervention attenuated the decrease in tSOS observed in Control infants (p<0.05). Urinary pyridinium crosslinks decreased over time in both TKS and CTL (p<0.005). TKS infants experienced greater increases in urinary osteocalcin (U-MidOC, p<0.001 and unOC, p<0.05). We conclude that TKS improves bone strength in premature infants by attenuating the decrease that normally follows preterm birth. Further, biomarkers of bone metabolism suggest a modification in bone turnover in TKS infants in favor of bone accretion. Taken together, we speculate that TKS improves bone mineralization. Copyright © 2012 Elsevier Inc. All rights reserved.

  17. 19 CFR 10.62 - Bunker fuel oil.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Bunker fuel oil. 10.62 Section 10.62 Customs... Equipment for Vessels § 10.62 Bunker fuel oil. (a) Withdrawal under section 309, Tariff Act of 1930, as... section 309, Tariff Act of 1930, as amended (19 U.S.C. 1309), when all the bunker fuel oil in a Customs...

  18. Impacts of Outer Continental Shelf (OCS) development on recreation and tourism. Volume 3. Detailed methodology

    Energy Technology Data Exchange (ETDEWEB)

    1987-04-01

    The final report for the project is presented in five volumes. This volume, Detailed Methodology Review, presents a discussion of the methods considered and used to estimate the impacts of Outer Continental Shelf (OCS) oil and gas development on coastal recreation in California. The purpose is to provide the Minerals Management Service with data and methods to improve their ability to analyze the socio-economic impacts of OCS development. Chapter II provides a review of previous attempts to evaluate the effects of OCS development and of oil spills on coastal recreation. The review also discusses the strengths and weaknesses of different approaches and presents the rationale for the methodology selection made. Chapter III presents a detailed discussion of the methods actually used in the study. The volume contains the bibliography for the entire study.

  19. 75 FR 71734 - Outer Continental Shelf (OCS), Scientific Committee (SC)

    Science.gov (United States)

    2010-11-24

    ... Environmental Studies Program (ESP) and environmental aspects of the offshore energy and marine minerals... oceanography, as well as studies of the social and economic impacts of OCS energy and marine minerals... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management, Regulation and Enforcement Outer...

  20. File list: InP.Unc.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Unc.10.Input_control.AllCell hg19 Input control Input control Unclassified SRX1...94492,SRX063292,SRX212465,SRX012413,ERX026985 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Unc.10.Input_control.AllCell.bed ...

  1. File list: InP.Epd.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Epd.10.Input_control.AllCell hg19 Input control Input control Epidermis SRX2000...54,SRX189959,SRX080365,SRX573182,SRX573176 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Epd.10.Input_control.AllCell.bed ...

  2. File list: InP.Oth.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Oth.10.Input_control.AllCell hg19 Input control Input control Others SRX668215,...RX371462,SRX376724,SRX512177,SRX512179 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Oth.10.Input_control.AllCell.bed ...

  3. 77 FR 14456 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2012-03-09

    ... operative on March 1, 2012. The text of the proposed rule change is available on the Exchange's Web site at..., fees and other charges among members and issuers and other persons using any facility or system which... Release No. 61358 (January 14, 2010), 75 FR 3594 (January 21, 2010) (Concept Release on Equity Market...

  4. 15 CFR 930.73 - OCS plan.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false OCS plan. 930.73 Section 930.73...) Exploration, Development and Production Activities § 930.73 OCS plan. (a) The term “OCS plan” means any plan... described in detail in OCS plans approved by the Secretary of the Interior or designee prior to management...

  5. File list: InP.Oth.10.AllAg.Tumour_tissues [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Oth.10.AllAg.Tumour_tissues hg19 Input control Others Tumour tissues SRX371456,...1,SRX371450,SRX371458,SRX371461,SRX371455,SRX371462 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Oth.10.AllAg.Tumour_tissues.bed ...

  6. File list: InP.CDV.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.CDV.10.Input_control.AllCell hg19 Input control Input control Cardiovascular SR...SRX190094,SRX190090,SRX189947,SRX080435,DRX021454,SRX699736 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.CDV.10.Input_control.AllCell.bed ...

  7. File list: InP.Pan.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Pan.10.Input_control.AllCell hg19 Input control Input control Pancreas SRX19030...8948,SRX825393,SRX199860,SRX190029,SRX026707,SRX375320 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Pan.10.Input_control.AllCell.bed ...

  8. 78 FR 47016 - Submission for Review: Request for External Review

    Science.gov (United States)

    2013-08-02

    ... OFFICE OF PERSONNEL MANAGEMENT Submission for Review: Request for External Review AGENCY: U.S... External Review. As required by the Paperwork Reduction Act of 1995, (Pub. L. 104-13, 44 U.S.C. chapter 35... the Multi-State Plan Program (MSPP) on March 11, 2013, 78 FR 15560, which outlined an external review...

  9. ^2H(^18F,p)^19F Study at 6 MeV/u

    Science.gov (United States)

    Kozub, R. L.; Nesaraja, C. D.; Moazen, B. H.; Scott, J. P.; Bardayan, D. W.; Blackmon, J. C.; Gross, C. J.; Shapira, D.; Smith, M. S.; Batchelder, J. C.; Brune, C. R.; Champagne, A. E.; Sahin, L.; Cizewski, J. A.; Thomas, J. S.; Davinson, T.; Woods, P. J.; Greife, U.; Jewett, C.; Livesay, R. J.; Ma, Z.; Parker, P. D.

    2003-04-01

    The degree to which the (p,α) and (p,γ) reactions destroy ^18F at temperatures ˜1-4 x 10^8 K is important for understanding the synthesis of nuclei in nova explosions and for using ^18F as a monitor of nova mechanisms in gamma ray astronomy. The reactions are dominated by low-lying proton resonances near the ^18F+p threshold (E_x=6.411 MeV excitation energy in ^19Ne). To gain further information about these resonances, we have used the inverse ^18F(d,p)^19F neutron transfer reaction at the Holifield Radioactive Ion Beam Facility to selectively populate corresponding mirror states in ^19F. Proton angular distributions were measured for states in ^19F in the excitation energy range 0-9 MeV. Results and implications for the ^18F+p reactions and nuclear structure will be presented. ^1Supported by DOE. ^2ORNL is managed by UT-Battelle, LLC, for the USDOE.

  10. File list: InP.Prs.10.AllAg.Prostate_cancer_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Prs.10.AllAg.Prostate_cancer_cells hg19 Input control Prostate Prostate cancer ...cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Prs.10.AllAg.Prostate_cancer_cells.bed ...

  11. File list: InP.Adp.10.AllAg.Adipose_Tissue,_White [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Adp.10.AllAg.Adipose_Tissue,_White hg19 Input control Adipocyte Adipose Tissue,... White http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Adp.10.AllAg.Adipose_Tissue,_White.bed ...

  12. File list: InP.Pan.10.AllAg.PANC-1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Pan.10.AllAg.PANC-1 hg19 Input control Pancreas PANC-1 SRX190309,SRX101486,SRX1...50696,SRX190252,SRX644404,SRX199860,SRX190029 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Pan.10.AllAg.PANC-1.bed ...

  13. File list: InP.Dig.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Dig.10.Input_control.AllCell hg19 Input control Input control Digestive tract S...RX155777,SRX077858,SRX863785,SRX543682,SRX286206,SRX543691 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Dig.10.Input_control.AllCell.bed ...

  14. File list: InP.Lng.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Lng.10.Input_control.AllCell hg19 Input control Input control Lung SRX502813,SR...74812,SRX016558,SRX734236,SRX038682,SRX497257,SRX497258 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Lng.10.Input_control.AllCell.bed ...

  15. File list: InP.CDV.10.AllAg.Brachiocephalic_endothelial_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.CDV.10.AllAg.Brachiocephalic_endothelial_cells hg19 Input control Cardiovascular Brachiocephal...ic endothelial cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.CDV.10.AllAg.Brachiocephalic_endothelial_cells.bed ...

  16. 22 CFR 19.10-3 - Marriage after retirement.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Marriage after retirement. 19.10-3 Section 19... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.10-3 Marriage after retirement. If an... marriage irrevocably elect to receive a reduced annuity and to provide, subject to any obligation to...

  17. Availability of emergency obstetric care (EmOC) among public and private health facilities in rural northwest Bangladesh.

    Science.gov (United States)

    Sikder, Shegufta S; Labrique, Alain B; Ali, Hasmot; Hanif, Abu A M; Klemm, Rolf D W; Mehra, Sucheta; West, Keith P; Christian, Parul

    2015-01-31

    Although safe motherhood strategies recommend that women seek timely care from health facilities for obstetric complications, few studies have described facility availability of emergency obstetric care (EmOC). We sought to describe and compare availability and readiness to provide EmOC among public and private health facilities commonly visited for pregnancy-related complications in two districts of northwest Bangladesh. We also described aspects of financial and geographic access to healthcare and key constraints to EmOC provision. Using data from a large population-based community trial, we identified and surveyed the 14 health facilities (7 public, 7 private) most frequently visited for obstetric complications and near misses as reported by women. Availability of EmOC was based on provision of medical services, assessed through clinician interviews and record review. Levels of EmOC availability were defined as basic or comprehensive. Readiness for EmOC provision was based on scores in four categories: staffing, equipment, laboratory capacity, and medicines. Readiness scores were calculated using unweighted averages. Costs of C-section procedures and geographic locations of facilities were described. Textual analysis was used to identify key constraints. The seven surveyed private facilities offered comprehensive EmOC compared to four of the seven public facilities. With 100% representing full readiness, mean EmOC readiness was 81% (range: 63%-91%) among surveyed private facilities compared to 67% (range: 48%-91%) in public facilities (p = 0.040). Surveyed public clinics had low scores on staffing and laboratory capacity (69%; 50%). The mean cost of the C-section procedure in private clinics was $77 (standard deviation: $16) and free in public facilities. The public sub-district facilities were the only facilities located in rural areas, with none providing comprehensive EmOC. Shortages in specialized staff were listed as the main barrier to EmOC provision in

  18. File list: InP.Gon.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

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  19. 77 FR 47877 - Potential Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore Maine...

    Science.gov (United States)

    2012-08-10

    ... Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore Maine; Request for Interest... Request for a Commercial OCS Wind Lease, Request for Interest, and Request for Public Comment SUMMARY: The... (Statoil NA) to acquire an OCS wind lease; (2) solicit public input regarding the proposal, its potential...

  20. File list: InP.Brs.10.AllAg.Breast_cancer_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Brs.10.AllAg.Breast_cancer_cells hg19 Input control Breast Breast cancer cells ...SRX155771,SRX155768 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Brs.10.AllAg.Breast_cancer_cells.bed ...

  1. Standard Review Plan for the review of financial assurance mechanisms for decommissioning under 10 CFR Parts 30, 40, 70, and 72

    International Nuclear Information System (INIS)

    1989-08-01

    Standard Review Plan (SRP) for the Review of Financial Assurance Mechanisms for Decommissioning under 10 CFR Parts 30, 40, 70 and 72, is prepared for the guidance of Nuclear Regulatory Commission staff reviewers in performing reviews of applications from material licensees affected by the decommissioning regulations established June 27, 1988 (53FR24018). The principal purpose of the SRP is to assure the quality and uniformity of staff reviews and to present a base from which to evaluate the financial assurance aspects of the applications. The SRP identifies who performs the review, the matters that are reviewed, the basis for the review, how the review is performed, and the conclusions that are sought

  2. 19 CFR 10.702 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... a claim that a good is entitled to the duty rate applicable under the US-JFTA; (b) Customs authority. “Customs authority” means the competent authority that is responsible under the law of a country for the... 19 Customs Duties 1 2010-04-01 2010-04-01 false Definitions. 10.702 Section 10.702 Customs Duties...

  3. File list: InP.Neu.10.AllAg.Adult_brains [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Neu.10.AllAg.Adult_brains hg19 Input control Neural Adult brains SRX643470,SRX6...43468,SRX643467,SRX643464,SRX643465,SRX643462,SRX643466,SRX643469,SRX643463 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Neu.10.AllAg.Adult_brains.bed ...

  4. 75 FR 54001 - Fifty-Second Meeting: RTCA Special Committee 186: Automatic Dependent Surveillance-Broadcast (ADS-B)

    Science.gov (United States)

    2010-09-02

    ... Revised Terms of Reference (TOR)--Discussion--Review/ Approval New Business. Other Business. Review Action... Advisory Committee. [FR Doc. 2010-21927 Filed 9-1-10; 8:45 am] BILLING CODE 4910-13-P ...

  5. 10 CFR 19.12 - Instruction to workers.

    Science.gov (United States)

    2010-01-01

    ... observe, to the extent within the workers control, the applicable provisions of Commission regulations and... 10 Energy 1 2010-01-01 2010-01-01 false Instruction to workers. 19.12 Section 19.12 Energy NUCLEAR REGULATORY COMMISSION NOTICES, INSTRUCTIONS AND REPORTS TO WORKERS: INSPECTION AND INVESTIGATIONS § 19.12...

  6. Neurological aspects of human parvovirus B19 infection: a systematic review

    Science.gov (United States)

    Barah, Faraj; Whiteside, Sigrid; Batista, Sonia; Morris, Julie

    2014-01-01

    Parvovirus B19 has been linked with various clinical syndromes including neurological manifestations. However, its role in the latter remains not completely understood. Although the last 10 years witnessed a surge of case reports on B19-associated neurological aspects, the literature data remains scattered and heterogeneous, and epidemiological information on the incidence of B19-associated neurological aspects cannot be accurately extrapolated. The aim of this review is to identify the characteristics of cases of B19-associated neurological manifestations. A computerized systematic review of existing literature concerning cases of B19-related neurological aspects revealed 89 articles describing 129 patients; 79 (61.2%) were associated with CNS manifestations, 41 (31.8%) were associated with peripheral nervous system manifestations, and 9 (7.0%) were linked with myalgic encephalomyelitis. The majority of the cases (50/129) had encephalitis. Clinical characteristic features of these cases were analyzed, and possible pathological mechanisms were also described. In conclusion, B19 should be included in differential diagnosis of encephalitic syndromes of unknown etiology in all age groups. Diagnosis should rely on investigation of anti-B19 IgM antibodies and detection of B19 DNA in serum or CSF. Treatment of severe cases might benefit from a combined regime of intravenous immunoglobulins and steroids. To confirm these outcomes, goal-targeted studies are recommended to exactly identify epidemiological scenarios and explore potential pathogenic mechanisms of these complications. Performing retrospective and prospective and multicenter studies concerning B19 and neurological aspects in general, and B19 and encephalitic syndromes in particular, are required. © 2014 The Authors. Reviews in Medical Virology published by John Wiley & Sons, Ltd. PMID:24459081

  7. 22 CFR 19.10 - Types of annuities to members.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Types of annuities to members. 19.10 Section 19.10 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR SPOUSES AND FORMER SPOUSES OF PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.10 Types of annuities to members. ...

  8. 77 FR 70583 - Patient Protection and Affordable Care Act; Health Insurance Market Rules; Rate Review

    Science.gov (United States)

    2012-11-26

    ... Parts 144, 147, 150, et al. Patient Protection and Affordable Care Act; Health Insurance Market Rules... and 156 [CMS-9972-P] RIN 0938-AR40 Patient Protection and Affordable Care Act; Health Insurance Market... Affordable Care Act with respect to health insurance issuers and group health plans that are non-federal...

  9. File list: InP.Bld.10.AllAg.M0-91 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Bld.10.AllAg.M0-91 hg19 Input control Blood M0-91 SRX262150,SRX262147,SRX262153...,SRX262144 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Bld.10.AllAg.M0-91.bed ...

  10. Pengaruh penggantian Bovine Serum Albumin (BSA dengan putih telur pada pengencer CEP-2 terhadap kualitas semen sapi Peranakan Ongole pada suhu penyimpanan 3-5oC

    Directory of Open Access Journals (Sweden)

    Nisa’us Sholikah

    2016-04-01

    Full Text Available Purpose of this research was to investigate the effect of Bovine Serum Albumin substitution by albumen on CEP-2 to semen quality Ongole CrossBred bull stored at 3-5oC. Research was conducted at Research Centre Beef Cattle Laboratory, Grati, Pasuruan on February 2016. Semen diluent was divided into two groups, there were P0 (90% CEP-2 + 10% Egg Yolk (EY; and P1 (90% CEP + 0.4% albumen + 10% EY. Data of the research were analyzed using paired design t test. The result showed that after eight days chilled preservation, percentage of motility P1 (47.4±10.9% was higher than P0 (47±9.2%. Percentage of viability P0 (83.1±1.9% was higher than P1 (81.3±1.5%. Percentage of abnormality P1 (3.6±0.4% was lower than P0 (3.8±0.3%. Total motile sperm count after six days chilled preservation was significantly higher in all treatments compared to the standard criteria of SNI 40% motile sperm/ml. The conclusion of this research was 0,4% albumen could replace the BSA capability on CEP-2. Keywords: CEP-2, Bovine Serum Albumin, chilled preservation, semen quality

  11. 77 FR 65656 - Determination of Attainment for the Nogales Nonattainment Area for the 2006 Fine Particle...

    Science.gov (United States)

    2012-10-30

    ...) (Baton Rouge, Louisiana, 1-hour ozone); 75 FR 27944 (May 19, 2010) (Coso Junction, California, PM 10... regulatory action'' subject to review by the Office of Management and Budget under Executive Order 12866 (58... economically significant regulatory action based on health or safety risks subject to Executive Order 13045 (62...

  12. 76 FR 64127 - Information Collection Requests Under OMB Review

    Science.gov (United States)

    2011-10-17

    ... Peace Corps Web site; provide stories and photos for use in exhibits, news articles and events about... collection request to the Office of Management and Budget (OMB) for approval. In compliance with the..., Management. [FR Doc. 2011-26723 Filed 10-14-11; 8:45 am] BILLING CODE 6051-01-P ...

  13. 19 CFR 146.26 - System review.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false System review. 146.26 Section 146.26 Customs... (CONTINUED) FOREIGN TRADE ZONES Inventory Control and Recordkeeping System § 146.26 System review. The operator shall perform an annual internal review of the inventory control and recordkeeping system and...

  14. 10 CFR 436.19 - Life cycle costs.

    Science.gov (United States)

    2010-01-01

    ... operation and maintenance costs: (c) Replacement costs less salvage costs of replaced building systems; and... 10 Energy 3 2010-01-01 2010-01-01 false Life cycle costs. 436.19 Section 436.19 Energy DEPARTMENT... Procedures for Life Cycle Cost Analyses § 436.19 Life cycle costs. Life cycle costs are the sum of the...

  15. 75 FR 81662 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Affordable...

    Science.gov (United States)

    2010-12-28

    .... SUMMARY: The Department of Labor (DOL) hereby announces the submission of the Employee Benefits Security... coverage for group health plans and health insurance issuers offering group or individual health insurance... health insurance issuer offering group or individual health insurance coverage generally must not rescind...

  16. 75 FR 63813 - Membership of the Bureau Industry Security Performance Review Board

    Science.gov (United States)

    2010-10-18

    ..., Department of Commerce Human Resources Operations Center (DOCHROC), Office of Executive Resources Operations... Administration. Susan Boggs, Director, Office of Staffing, Recruitment and Classification, Department of Commerce Human Resources Operations Center. [FR Doc. 2010-26168 Filed 10-15-10; 8:45 am] BILLING CODE 3510-25-P ...

  17. 19 CFR 10.101 - Immediate delivery.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Immediate delivery. 10.101 Section 10.101 Customs... Importations § 10.101 Immediate delivery. (a) Shipments entitled to immediate delivery. Shipments consigned to... as shipments the immediate delivery of which is necessary within the purview of section 448(b...

  18. 19 CFR 10.33 - Theatrical effects.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Theatrical effects. 10.33 Section 10.33 Customs... Under Bond § 10.33 Theatrical effects. For purposes of the entry of theatrical scenery, properties and... films. For provisions relating to the return without formal entry of theatrical effects taken from the...

  19. 78 FR 22545 - Performance Review Board

    Science.gov (United States)

    2013-04-16

    ... FURTHER INFORMATION CONTACT: Harriette H. Charbonneau, Director of Human Resources, Federal Maritime... prescribed by the Office of Personnel Management, one or more performance review boards. The board shall..., Managing Director 15. Austin L. Schmitt, Director, Strategic Planning and Regulatory Review [FR Doc. 2013...

  20. 78 FR 67177 - Center for Scientific Review; Amended Notice of Meeting

    Science.gov (United States)

    2013-11-08

    ... Technology A Study Section, October 07, 2013, 08:00 a.m. to October 08, 2013, 05:00 p.m., Hilton Alexandria... September 10, 2013, 78 FR 175 Pgs. 55268-55270. The meeting will be held at the Hilton Rockville, 1750...

  1. Peroxidase activity in roots of arracacha affected by pH and temperature = Atividade da peroxidase em raízes de batata-baroa afetada pelo pH e temperatura

    Directory of Open Access Journals (Sweden)

    Luciana Nunes Menolli

    2011-07-01

    Full Text Available In this paper, roots of arracacha (Arracacia xanthorrhyza Bancroft were stored at 5ºC to induce chilling injury symptoms and stress-related peroxidase activity. Later, peroxidase kinetic activity was determined in different pH and temperature conditions. For this, soluble crude extract was sequentially saturated with ammonium sulfate, obtaining a semi-purified enzyme solution used for the analysis. Activity of peroxidase induced by the chilling at 5oC was determined from pH 2.5 to 9.0 and at temperature ranging from 10 to80oC. The peroxidase had higher activity when the reaction occurred between pH 5.5 and 6.0 and at temperature of 30oC. Complete inactivation of the activity was observed in pH 2.5 after 60 minutes of pre-incubation or at 60oC for 10 minutes or alternatively at 70oCafter 5 minutes of pre-incubation. The enzyme is more susceptible to inactivation in acid than alkaline pHs or alternatively using heat treatment.Neste trabalho, raízes de batata-baroa (Arracacia xanthorrhiza Bancroft foram armazenadas a 5oC para induzir injúria por frio e expressar atividade da peroxidase de estresse. Posteriormente, a cinética de atividade foi determinada em diferentes condições depHs e temperatura. Para isto, extrato solúvel da raiz foi sequencialmente saturado com sulfato de amônio, obtendo-se uma preparação semi-purificada para a análise enzimática. Atividade peroxidativa induzida pela temperatura de armazenamento de 5oC foideterminada em pHs de 2,5 a 9,0 e a temperaturas de 10 a 80oC. A atividade da peroxidase foi maior quando a reação foi realizada nos pHs de 5,5 e 6,0 e temperatura de 30oC. A inativação completa da enzima ocorreu em pH de 2,5 após 60 min. de pré-incubação ou a60oC por 10 min., e alternativamente a 70oC após 5 min. de pré-incubação. A enzima foi mais susceptível à inativação em pH ácido do que alcalino, podendo também ser inativada pelo tratamento de calor.

  2. File list: InP.Bld.10.AllAg.Peripheral_blood_stem_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Bld.10.AllAg.Peripheral_blood_stem_cells hg19 Input control Blood Peripheral bl...ood stem cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Bld.10.AllAg.Peripheral_blood_stem_cells.bed ...

  3. OCS National Compendium

    Energy Technology Data Exchange (ETDEWEB)

    Gould, G.J.; Karpas, R.M.; Slitor, D.L.

    1991-06-01

    The Minerals Management Service's (MMS) Outer Continental Shelf Information Program (OCSIP) is responsible for making available to affected coastal States, local governments, and other interested parties data and information related to the Outer Continental Shelf (OCS) Oil and Gas Program. Since its establishment through Section 26 of the OCS Lands Act (OCSLA) Amendments of 1978, OCSIP has prepared regional summary reports, updates, and indexes on leasing, exploration, development, and production activities to fulfill the mandates of the OCSLA Amendments. The OCSIP receives many requests for out-of-print summary reports, updates, and indexes. The purpose of the OCS National Compendium is to consolidate these historical data and to present the data on an OCS-wide and regional scale. The single-volume approach allows the reader access to historical information and facilitates regional comparisons. The fold-out chart in the front of this publication provides the reader with a timeline (January 1988--November 1990) of events since publication of the last Compendium. Some of the events are directly related to the 5-year Oil and Gas Program, whereas others may or may not have an effect on the program. A predominantly graphic format is used in the report so that the large accumulation of data can be more readily comprehended. In some cases, it is not possible to update information through October 21, 1990, because of the nature of the data. For example, production data normally lags 3 months. 58 figs., 37 tabs.

  4. 75 FR 80511 - Center for Scientific Review; Notice of Closed Meeting

    Science.gov (United States)

    2010-12-22

    ...: Cognition and Perception. Date: January 19-20, 2011. Time: 12 p.m. to 6 p.m. Agenda: To review and evaluate... (Virtual Meeting). Contact Person: Weijia Ni, PhD, Scientific Review Officer, Center for Scientific Review...

  5. 77 FR 12801 - Certain Frozen Warmwater Shrimp From the People's Republic of China: Preliminary Results, Partial...

    Science.gov (United States)

    2012-03-02

    ..., the Department preliminarily determines that the respondents in this review did not make sales in the... Administrative Review, 76 FR 51940 (August 19, 2011). Based on our examination of the sales data submitted by... Administrative Review, 66 FR 27063 (May 16, 2001); Notice of Final Determination of Sales at Less Than Fair Value...

  6. IR photodissociation spectroscopy of (OCS){sub n}{sup +} and (OCS){sub n}{sup −} cluster ions: Similarity and dissimilarity in the structure of CO{sub 2}, OCS, and CS{sub 2} cluster ions

    Energy Technology Data Exchange (ETDEWEB)

    Inokuchi, Yoshiya, E-mail: y-inokuchi@hiroshima-u.ac.jp; Ebata, Takayuki [Department of Chemistry, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan)

    2015-06-07

    Infrared photodissociation (IRPD) spectra of (OCS){sub n}{sup +} and (OCS){sub n}{sup −} (n = 2–6) cluster ions are measured in the 1000–2300 cm{sup −1} region; these clusters show strong CO stretching vibrations in this region. For (OCS){sub 2}{sup +} and (OCS){sub 2}{sup −}, we utilize the messenger technique by attaching an Ar atom to measure their IR spectra. The IRPD spectrum of (OCS){sub 2}{sup +}Ar shows two bands at 2095 and 2120 cm{sup −1}. On the basis of quantum chemical calculations, these bands are assigned to a C{sub 2} isomer of (OCS){sub 2}{sup +}, in which an intermolecular semi-covalent bond is formed between the sulfur ends of the two OCS components by the charge resonance interaction, and the positive charge is delocalized over the dimer. The (OCS){sub n}{sup +} (n = 3–6) cluster ions show a few bands assignable to “solvent” OCS molecules in the 2000–2080 cm{sup −1} region, in addition to the bands due to the (OCS){sub 2}{sup +} ion core at ∼2090 and ∼2120 cm{sup −1}, suggesting that the dimer ion core is kept in (OCS){sub 3–6}{sup +}. For the (OCS){sub n}{sup −} cluster anions, the IRPD spectra indicate the coexistence of a few isomers with an OCS{sup −} or (OCS){sub 2}{sup −} anion core over the cluster range of n = 2–6. The (OCS){sub 2}{sup −}Ar anion displays two strong bands at 1674 and 1994 cm{sup −1}. These bands can be assigned to a C{sub s} isomer with an OCS{sup −} anion core. For the n = 2–4 anions, this OCS{sup −} anion core form is dominant. In addition to the bands of the OCS{sup −} core isomer, we found another band at ∼1740 cm{sup −1}, which can be assigned to isomers having an (OCS){sub 2}{sup −} ion core; this dimer core has C{sub 2} symmetry and {sup 2}A electronic state. The IRPD spectra of the n = 3–6 anions show two IR bands at ∼1660 and ∼2020 cm{sup −1}. The intensity of the latter component relative to that of the former one becomes stronger and stronger with

  7. 78 FR 36571 - North American Datum of 1983 (NAD 83) Outer Continental Shelf (OCS) Provisional Official...

    Science.gov (United States)

    2013-06-18

    ... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management [MMAA104000] North American Datum of 1983 (NAD 83) Outer Continental Shelf (OCS) Provisional Official Protraction Diagram (OPDs) AGENCY... OPDs. SUMMARY: Notice is hereby given that effective with this publication two NAD 83-based OCS...

  8. File list: InP.Bld.10.AllAg.Lymphoma,_B-Cell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Bld.10.AllAg.Lymphoma,_B-Cell hg19 Input control Blood Lymphoma, B-Cell SRX3703...41,SRX370343,SRX370347,SRX370349,SRX370351,SRX370345,SRX092417,SRX092415 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Bld.10.AllAg.Lymphoma,_B-Cell.bed ...

  9. 19 CFR 10.430 - Export requirements.

    Science.gov (United States)

    2010-04-01

    ... Chile customs authority for that purpose) to CBP upon request. (b) Notification of errors in... 19 Customs Duties 1 2010-04-01 2010-04-01 false Export requirements. 10.430 Section 10.430 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY...

  10. Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: Integrated Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Cano-Sancho, German; Salmon, Andrew G; La Merrill, Michele A

    2017-09-18

    The prevalence of obesity is increasing in all countries, becoming a substantial public health concern worldwide. Increasing evidence has associated obesity with persistent pollutants such as the pesticide DDT and its metabolite p,p '-DDE. Our objective was to systematically review the literature on the association between exposure to the pesticide DDT and its metabolites and obesity to develop hazard identification conclusions. We applied a systematic review-based strategy to identify and integrate evidence from epidemiological, in vivo , and in vitro studies. The evidence from prospective epidemiological studies was quantitatively synthesized by meta-analysis. We rated the body of evidence and integrated the streams of evidence to systematically develop hazard identification conclusions. We identified seven epidemiological studies reporting prospective associations between exposure to p,p' -DDE and adiposity assessed by body mass index (BMI) z -score. The results from the meta-analysis revealed positive associations between exposure to p,p' -DDE and BMI z -score (β=0.13 BMI z -score (95% CI: 0.01, 0.25) per log increase of p,p' -DDE). Two studies constituted the primary in vivo evidence. Both studies reported positive associations between exposure to p,p' -DDT and increased adiposity in rodents. We identified 19 in vivo studies and 7 in vitro studies that supported the biological plausibility of the obesogenic effects of p,p' -DDT and p,p' -DDE. We classified p,p' -DDT and p,p' -DDE as "presumed" to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527.

  11. Subtelomeric deletion of chromosome 10p15.3: clinical findings and molecular cytogenetic characterization.

    Science.gov (United States)

    DeScipio, Cheryl; Conlin, Laura; Rosenfeld, Jill; Tepperberg, James; Pasion, Romela; Patel, Ankita; McDonald, Marie T; Aradhya, Swaroop; Ho, Darlene; Goldstein, Jennifer; McGuire, Marianne; Mulchandani, Surabhi; Medne, Livija; Rupps, Rosemarie; Serrano, Alvaro H; Thorland, Erik C; Tsai, Anne C-H; Hilhorst-Hofstee, Yvonne; Ruivenkamp, Claudia A L; Van Esch, Hilde; Addor, Marie-Claude; Martinet, Danielle; Mason, Thornton B A; Clark, Dinah; Spinner, Nancy B; Krantz, Ian D

    2012-09-01

    We describe 19 unrelated individuals with submicroscopic deletions involving 10p15.3 characterized by chromosomal microarray (CMA). Interestingly, to our knowledge, only two individuals with isolated, submicroscopic 10p15.3 deletion have been reported to date; however, only limited clinical information is available for these probands and the deleted region has not been molecularly mapped. Comprehensive clinical history was obtained for 12 of the 19 individuals described in this study. Common features among these 12 individuals include: cognitive/behavioral/developmental differences (11/11), speech delay/language disorder (10/10), motor delay (10/10), craniofacial dysmorphism (9/12), hypotonia (7/11), brain anomalies (4/6) and seizures (3/7). Parental studies were performed for nine of the 19 individuals; the 10p15.3 deletion was de novo in seven of the probands, not maternally inherited in one proband and inherited from an apparently affected mother in one proband. Molecular mapping of the 19 individuals reported in this study has identified two genes, ZMYND11 (OMIM 608668) and DIP2C (OMIM 611380; UCSC Genome Browser), mapping within 10p15.3 which are most commonly deleted. Although no single gene has been identified which is deleted in all 19 individuals studied, the deleted region in all but one individual includes ZMYND11 and the deleted region in all but one other individual includes DIP2C. There is not a clearly identifiable phenotypic difference between these two individuals and the size of the deleted region does not generally predict clinical features. Little is currently known about these genes complicating a direct genotype/phenotype correlation at this time. These data however, suggest that ZMYND11 and/or DIP2C haploinsufficiency contributes to the clinical features associated with 10p15 deletions in probands described in this study. Copyright © 2012 Wiley Periodicals, Inc.

  12. 19 CFR 10.846 - Imported directly.

    Science.gov (United States)

    2010-04-01

    ... they: (i) Remained under the control of the customs authority in the intermediate country; (ii) Did not... 19 Customs Duties 1 2010-04-01 2010-04-01 false Imported directly. 10.846 Section 10.846 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY...

  13. 19 CFR 10.204 - Imported directly.

    Science.gov (United States)

    2010-04-01

    ... customs authority in the intermediate country; (2) Did not enter into the commerce of the intermediate... 19 Customs Duties 1 2010-04-01 2010-04-01 false Imported directly. 10.204 Section 10.204 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY...

  14. Carbonyl sulfide (OCS) as a proxy for GPP: Complications derived from studies on the impact of CO2, soil humidity and sterilization on the OCS exchange between soils and atmosphere

    Science.gov (United States)

    Bunk, Rüdiger; Behrendt, Thomas; Yi, Zhigang; Kesselmeier, Jürgen

    2016-04-01

    Carbonyl sulfide is discussed to be used as a proxy for gross primary productivity (GPP) of forest ecosystems. However, soils may interfere. Soils play an important role in budgeting global and local carbonyl sulfide (OCS) fluxes, yet the available data on the uptake and emission behavior of soils in conjunction with environmental factors is limited. The work of many authors has shown that the OCS exchange of soils depends on various factors, such as soil type, atmospheric OCS concentrations, temperature or soil water content (Kesselmeier et al., J. Geophys. Res., 104, No. D9, 11577-11584, 1999; Van Diest & Kesselmeier, Biogeosciences, 5, 475-483, 2008; Masyek et al., PNAS, 111, No 25, 9064-9069, doi: 10.1073/pnas.1319132111, 2014; Whelan and Rhew, J. Geophys. Res. Biogeosciences., 120, 54-62, doi: 10.1002/2014JG002661, 2015) and the light dependent and obviously abiotic OCS production as reported by Whelan and Rhew (2015). To get a better constraint on the impact of some environmental factors on the OCS exchange of soils we used a new laser based integrated cavity output spectroscopy instrument (LGR COS/CO Analyzer Model 907-0028, Los Gatos, Mountain View, California, USA) in conjunction with an automated soil chamber system (as described in Behrendt et al, Biogeosciences, 11, 5463-5492, doi: 10.5194/bg-11-5463-2014, 2014). The OCS exchange of various soils under the full range of possible soil humidity and various CO2 mixing ratios was examined. Additionally OCS exchange of chloroform sterilized subsamples was compared to their live counterparts to illuminate the influence of microorganisms. Results were quite heterogeneous between different soils. With few exceptions, all examined soils show dependence between OCS exchange and soil humidity, usually with strongest uptake at a certain humidity range and less uptake or even emission at higher and lower humidity. Differences in CO2 mixing ratio also clearly impacts on OCS exchange, but trends for different soils

  15. 22 CFR 19.10-6 - Benefits for recall service.

    Science.gov (United States)

    2010-04-01

    ... the basis of total service during the recall period and months of marriage during such period. If the... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Benefits for recall service. 19.10-6 Section 19... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.10-6 Benefits for recall service. (a...

  16. 77 FR 74847 - Modifications to Statement of Policy for Section 19 of the Federal Deposit Insurance Act

    Science.gov (United States)

    2012-12-18

    ...) participating in the affairs of Bank Holding Companies, or Savings and Loan Holding Companies. The FDIC, in 2011... Section 19 to include coverage of IAPs of Bank Holding Companies, and Savings and Loan Holding Companies... Supervision's in regard to bank and savings and loan holding companies under Section 19. (72 FR 73823...

  17. File list: InP.Utr.10.AllAg.Fallopian_tube_secretory_epithelial_cell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Utr.10.AllAg.Fallopian_tube_secretory_epithelial_cell hg19 Input control Uterus Fallopian tube secret...iencedbc.jp/kyushu-u/hg19/assembled/InP.Utr.10.AllAg.Fallopian_tube_secretory_epithelial_cell.bed ...

  18. 19 CFR 10.193 - Imported directly.

    Science.gov (United States)

    2010-04-01

    ... control of the customs authority of the intermediate country; (2) Did not enter into the commerce of the... 19 Customs Duties 1 2010-04-01 2010-04-01 false Imported directly. 10.193 Section 10.193 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY...

  19. Study of the D(p,π+)T and 9Be(p,π+)10Be from 400 to 800MeV

    International Nuclear Information System (INIS)

    Aslanides, E.; Bauer, T.; Bertini, R.; Beurtey, R.; Bimbot, L.; Bing, O.; Boudard, A.; Brochard, F.; Bruge, G.; Catz, H.; Chaumeaux, A.; Couvert, P.; Duchazeaubeneix, J.C.; Duhm, H.; Garreta, D.; Gorodetzky, P.; Habault, J.; Hibou, F.; Igo, G.; Le Bornec, Y.; Lugol, J.C.; Matoba, M.; Tatischeff, B.; Terrien, Y.

    Pion production on CD 2 and 9 Be targets has been observed using the high resolution, energy loss, spectrometer SPES I. Differential cross sections for the D(p,π + ) reaction have been determined at 410, 605 and 809MeV and for the 9 Be(p,π + ) reaction at 410 and 605MeV. The 3.37MeV (2 + ) state in 10 Be is populated preferentially, but a significant part of the transition strength seems to populate the ground state and the higher lying multiplets at about 6.1MeV, 7.4MeV and 9.4MeV [fr

  20. Interim guidance on the Standard Review Plan for the review of financial assurance mechanisms for decommissioning under 10 CFR Parts 30, 40, and 70

    International Nuclear Information System (INIS)

    1988-12-01

    Interim Guidance on the Standard Review Plan (SRP) for the Review of Financial Assurance Mechanisms for Decommissioning under 10 CFR Parts 30, 40, and 70 is prepared for the guidance of Nuclear Regulatory Commission staff reviewers in performing reviews of applications from material licensees affected by the decommissioning regulations established June 27, 1988 (53FR24018). The principal purpose of the SRP is to assure the quality and uniformity of staff reviews and to present a base from which to evaluate the financial assurance aspects of the applications. NUREG-1337, identifies who performs the review, the matters that are reviewed, the basis of the review, how the review is performed, and the conclusions that are sought. 3 refs

  1. 19 CFR 207.115 - Petition for review.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Petition for review. 207.115 Section 207.115... and Committee Proceedings § 207.115 Petition for review. (a) The petition and responses. (1) Any party... Secretary a petition for review, except that a party who has defaulted may not petition for review of any...

  2. Novel 19F MRS/I nanoprobe based on pH-responsive PEGylated nanogel. pH-dependent 19F magnetic resonance studies

    International Nuclear Information System (INIS)

    Oishi, Motoi; Sumitani, Shogo; Nagasaki, Yukio; Bronich, Tatiana K.; Kabanov, Alexander V.; Boska, Michael D.

    2009-01-01

    The pH-responsive PEGylated nanogels composed of the cross-linked poly[2-(N,N-diethylamino)ethyl methacrylate]-co-poly(2,2,2-trifluoroethyl methacrylate) gel core showed a remarkable on-off regulation of 19 F magnetic resonance signal intensity (T 2 values) as well as signal-to-noise ratios in response to extracellular pH 6.5 of tumor environment under 19 F magnetic resonance spectroscopic imaging (MRS/I), demonstrating the utility of the PEGylated nanogels as solid tumor-specific 19 F MRI/S nanoprobes. (author)

  3. Construction and engineering of a thermostable self-sufficient cytochrome P450

    Energy Technology Data Exchange (ETDEWEB)

    Mandai, Takao; Fujiwara, Shinsuke [Nanobiotechnology Research Center and Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda 669-1337 (Japan); Imaoka, Susumu, E-mail: imaoka@kwansei.ac.jp [Nanobiotechnology Research Center and Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda 669-1337 (Japan)

    2009-06-19

    CYP175A1 is a thermophilic cytochrome P450 and hydroxylates {beta}-carotene. We previously identified a native electron transport system for CYP175A1. In this report, we constructed two fusion proteins consisting of CYP175A1, ferredoxin (Fdx), and ferredoxin-NADP{sup +} reductase (FNR): H{sub 2}N-CYP175A1-Fdx-FNR-COOH (175FR) and H{sub 2}N-CYP175A1-FNR-Fdx-COOH (175RF). Both 175FR and 175RF were expressed in Escherichia coli and purified. The V{sub max} value for {beta}-carotene hydroxylation was 25 times higher with 175RF than 175FR and 9 times higher with 175RF than CYP175A1 (non-fused protein), although the k{sub m} values of these enzymes were similar. 175RF retained 50% residual activity even at 80 {sup o}C. Furthermore, several mutants of the CYP175A1 domain of 175RF were prepared and one mutant (Q67G/Y68I) catalyzed the hydroxylation of an unnatural substrate, testosterone. Thus, this is the first report of a thermostable self-sufficient cytochrome P450 and the engineering of a thermophilic cytochrome P450 for the oxidation of an unnatural substrate.

  4. 19 CFR 212.27 - Agency review.

    Science.gov (United States)

    2010-04-01

    ... IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT Procedures for Considering Applications § 212.27 Agency review... 19 Customs Duties 3 2010-04-01 2010-04-01 false Agency review. 212.27 Section 212.27 Customs... determination and alternative findings of fact and conclusions of law with the Commission. Upon receipt of the...

  5. 19 CFR 212.10 - Contents of application.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Contents of application. 212.10 Section 212.10 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 212.10...

  6. 19 CFR 191.10 - Certificate of delivery.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Certificate of delivery. 191.10 Section 191.10... TREASURY (CONTINUED) DRAWBACK General Provisions § 191.10 Certificate of delivery. (a) Purpose; when... other party a certificate of delivery, certified by the importer or other party through whose possession...

  7. [Geisteswissenschaft und Publizistik im Baltikum des 19. und frühen 20. Jahrhunderts] / Manfred von Boetticher

    Index Scriptorium Estoniae

    Boetticher, Manfred von, 1947-

    2012-01-01

    Arvustus: Geisteswissenschaft und Publizistik im Baltikum des 19. und frühen 20. Jahrhunderts (Schriften der Baltischen Historischen Kommission, 17; Baltische Biographische Forschungen, 1). Hrsg. von Norbert Angermann, Wilhelm Lenz und Konrad Maier. (Berlin: LIT-Varlag, 2011)

  8. 18 CFR 284.303 - OCS blanket certificates.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false OCS blanket certificates. 284.303 Section 284.303 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Pipelines on Behalf of Others § 284.303 OCS blanket certificates. Every OCS pipeline [as that term is...

  9. 49 CFR 1242.10 - Administration-track (account XX-19-02).

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Administration-track (account XX-19-02). 1242.10... Structures § 1242.10 Administration—track (account XX-19-02). Separate common administration—track expenses... accounts are separated between freight and passenger services: Roadway: Running (XX-17-10) Switching (XX-18...

  10. 19 CFR 10.542 - Third country transportation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Third country transportation. 10.542 Section 10.542 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF... Trade Agreement Rules of Origin § 10.542 Third country transportation. (a) General. A good will not be...

  11. 19 CFR 10.532 - Integrated Sourcing Initiative.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Integrated Sourcing Initiative. 10.532 Section 10... Trade Agreement Rules of Origin § 10.532 Integrated Sourcing Initiative. (a) For purposes of General... Sourcing Initiative if: (1) The good, in its condition as imported, is both classified in a tariff...

  12. 19 CFR 10.454 - Regional value content.

    Science.gov (United States)

    2010-04-01

    ... TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Chile Free Trade Agreement Rules of Origin § 10.454 Regional value content. Where General Note 26, subdivision (n), HTSUS... 19 Customs Duties 1 2010-04-01 2010-04-01 false Regional value content. 10.454 Section 10.454...

  13. 19 CFR 10.222 - Definitions.

    Science.gov (United States)

    2010-04-01

    ...” means a “beneficiary country” as defined in § 10.191(b)(1) for purposes of the CBERA which the President... apparel articles under 19 U.S.C. 2703(b)(2) and which has been the subject of a finding by the President... Mexico on December 17, 1992. Preferential treatment. “Preferential treatment” means entry, or withdrawal...

  14. 19 CFR 10.242 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... “beneficiary country” as defined in § 10.202(a) for purposes of the ATPA which the President also has... articles under 19 U.S.C. 3203(b)(3) and which has been the subject of a determination by the President or... entered into by the United States, Canada, and Mexico on December 17, 1992. Preferential treatment...

  15. Might generic OCs create contraceptive price war?

    Science.gov (United States)

    1987-02-01

    Genora 1/35 and 1/50, the 1st generic oral contraceptives (OCs) in the world, are now being marketed in the US. Clinicians interviewed by "Contraceptive Technology Update" (CTU) offer differing opinions as to what this new OC may mean in the marketplace. Products of Rugby Laboratories, the pills are copy products of Ortho Pharmaceutical's ON 1/35 and ON 1/50 formulations. Most clinicians believe that Genora's success or failure in the OC market depends on its eventual retail price. The price difference of $3-$4 may be sufficiently substantial for retailers to charge less for the generic OCs. If that is the case, many doctors may prescribe a pill which will save their patients $4/month. Dr. Mildred Hanson, a Minneapolis gynecologist/obstetrician, feels any cost savings from Genora will have a significant impact on the OC market. She suggests that the less expensive OCs will catch the attention of health maintenance organizations (HMOs) and the business of women who participate in such health plans. Yet James Burns, director of family planning services for the Hartford City Health Department, thinks that even a full-scale retail price war won't have much effect from a clinic standpoint. He reports that clinics are able to obtain contraceptive supplies rather inexpensively through the contracting system. Hanson also expressed doubt over the potential popularity of Genora 1/50 as clinical concerns about the effects of combined OCs on serum lipid levels and carbohydrate metabolism have resulted in a nationwide push toward OCs containing less than 50 micrograms of estrogen. He indicated concern that declines in pharmaceutical house products from pricing competition with generic pills might have a negative impact on contraceptive research and development. Dick Haskitt, director of business planning for Syntex Laboratories, Inc., who will produce the OCs for Rugby, reports that their market research shows that people are very interested in having a generic OC available

  16. 17 CFR 240.13e-3 - Going private transactions by certain issuers or their affiliates.

    Science.gov (United States)

    2010-04-01

    ... quoted in an inter-dealer quotation system of a registered national securities association. (3) [Reserved... a merger, (iii) any acquisition of fractional interests in connection with a reverse stock split... securities of the issuer involving the purchase of fractional interests. (ii) The effects referred to in...

  17. 76 FR 60871 - Ball Bearings and Parts Thereof From France, Germany, and Italy; Termination of Five-Year Reviews

    Science.gov (United States)

    2011-09-30

    ...The subject five-year reviews were initiated in August 2011 to determine whether revocation of the antidumping duty orders on ball bearings and parts thereof from France, Germany, and Italy would be likely to lead to continuation or recurrence of material injury. The Department of Commerce published notice that it was revoking the order effective September 15, 2011, because ``no domestic interested party filed a notice of intent to participate in response to the notice of initiation of the sunset reviews by the applicable deadline.'' (76 FR 57019). Accordingly, pursuant to section 751(c) of the Tariff Act of 1930 (19 U.S.C. 1675(c)), the subject reviews are terminated.

  18. 75 FR 13803 - SeaCo Ltd.; Notice of Application

    Science.gov (United States)

    2010-03-23

    ... value of the issuer's total assets (exclusive of Government securities and cash items) on an... subsidiaries, no more than 45% of an issuer's total assets (exclusive of Government securities and cash items... monitoring the performance of GE SeaCo operations, 7-10% of their time making decisions regarding the owned...

  19. 75 FR 51980 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-08-24

    .... Flynn, Director, Office of Competition and Economic Analysis, International Trade Administration, by... found at 15 CFR part 325 (2010). The Office of Competition and Economic Analysis (``OCEA'') is issuing...). Dated: August 19, 2010. Joseph E. Flynn, Director, Office of Competition and Economic Analysis. [FR Doc...

  20. [Geisteswissenschaften und Publizistik im Baltikum des 19. und frühen 20. Jahrhunderts] / Gert von Pistohlkors

    Index Scriptorium Estoniae

    Pistohlkors, Gert von, 1935-

    2013-01-01

    Arvustus: Geisteswissenschaften und Publizistik im Baltikum des 19. und frühen 20. Jahrhunderts. Hrsg. von Norbert Angermann, Wilhelm Lenz und Konrad Maier. (Schriften der Baltischen Historischen Kommission, Bd. 17; Baltische Biographische Forschungen, Bd. 1.) Lit. Münster 2011

  1. 15 CFR 2008.19 - Classification Review Committee.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Classification Review Committee. 2008.19 Section 2008.19 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE UNITED...

  2. 78 FR 30318 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-05-22

    ... Computational Mass-Spectrometry. Date: June 19-21, 2013. Time: 7:00 p.m. to 1:00 p.m. Agenda: To review and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict...

  3. 75 FR 68824 - Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore Maryland-Request...

    Science.gov (United States)

    2010-11-09

    ... No. BOEM-2010-0038] Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore..., Interior. ACTION: RFI in Commercial Wind Energy Leasing Offshore Maryland, and Invitation for Comments from... construction of a wind energy project(s) on the Outer Continental Shelf (OCS) offshore Maryland. The BOEMRE...

  4. 19 CFR 210.10 - Institution of investigation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Institution of investigation. 210.10 Section 210.10 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Commencement of Preinstitution Proceedings and Investigations...

  5. The O-C2 angle established at occipito-cervical fusion dictates the patient's destiny in terms of postoperative dyspnea and/or dysphagia.

    Science.gov (United States)

    Izeki, Masanori; Neo, Masashi; Takemoto, Mitsuru; Fujibayashi, Shunsuke; Ito, Hiromu; Nagai, Koutatsu; Matsuda, Shuichi

    2014-02-01

    We have revealed that the cause of postoperative dyspnea and/or dysphagia after occipito-cervical (O-C) fusion is mechanical stenosis of the oropharyngeal space and the O-C2 alignment, rather than total or subaxial alignment, is the key to the development of dyspnea and/or dysphagia. The purpose of this study was to confirm the impact of occipito-C2 angle (O-C2A) on the oropharyngeal space and to investigate the chronological impact of a fixed O-C2A on the oropharyngeal space and dyspnea and/or dysphagia after O-C fusion. We reviewed 13 patients who had undergone O-C2 fusion, while retaining subaxial segmental motion (OC2 group) and 20 who had subaxial fusion without O-C2 fusion (SA group). The O-C2A, C2-C6 angle and the narrowest oropharyngeal airway space were measured on lateral dynamic X-rays preoperatively, when dynamic X-rays were taken for the first time postoperatively, and at the final follow-up. We also recorded the current dyspnea and/or dysphagia status at the final follow-up of patients who presented with it immediately after the O-C2 fusion. There was no significant difference in the mean preoperative values of the O-C2A (13.0 ± 7.5 in group OC2 and 20.1 ± 10.5 in group SA, Unpaired t test, P = 0.051) and the narrowest oropharyngeal airway space (17.8 ± 6.0 in group OC2 and 14.9 ± 3.9 in group SA, Unpaired t test, P = 0.105). In the OC2 group, the narrowest oropharyngeal airway space changed according to the cervical position preoperatively, but became constant postoperatively. In contrast, in the SA group, the narrowest oropharyngeal airway space changed according to the cervical position at any time point. Three patients who presented with dyspnea and/or dysphagia immediately after O-C2 fusion had not resolved completely at the final follow-up. The narrowest oropharyngeal airway space and postoperative dyspnea and/or dysphagia did not change with time once the O-C2A had been established at O-C fusion. The O-C2A established at O-C

  6. 19 CFR 10.152 - Bona-fide gifts.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Bona-fide gifts. 10.152 Section 10.152 Customs... and Bona Fide Gifts § 10.152 Bona-fide gifts. Subject to the conditions in § 10.153 of this part, the port director shall pass free of duty and tax any article sent as a bona-fide gift from a person in a...

  7. 19 CFR 10.536 - Value of materials.

    Science.gov (United States)

    2010-04-01

    ...) Accounting method. Any cost or value referenced in General Note 25, HTSUS and this subpart, must be recorded... 19 Customs Duties 1 2010-04-01 2010-04-01 false Value of materials. 10.536 Section 10.536 Customs... Rules of Origin § 10.536 Value of materials. (a) Calculating the value of materials. Except as provided...

  8. 19 CFR 10.455 - Value of materials.

    Science.gov (United States)

    2010-04-01

    ... Chile or of the United States. (c) Accounting method. Any cost or value referenced in General Note 26(n... 19 Customs Duties 1 2010-04-01 2010-04-01 false Value of materials. 10.455 Section 10.455 Customs... of Origin § 10.455 Value of materials. (a) Calculating the regional value content. For purposes of...

  9. 19 CFR 10.596 - Value of materials.

    Science.gov (United States)

    2010-04-01

    ... in the territory of one or more of the Parties. (d) Accounting method. Any cost or value referenced... 19 Customs Duties 1 2010-04-01 2010-04-01 false Value of materials. 10.596 Section 10.596 Customs... States Free Trade Agreement Rules of Origin § 10.596 Value of materials. (a) Calculating the value of...

  10. SINTESIS 4,10,16,22-TETRAMETOKSIKALIKS[4] ARENA DARI MINYAK ADAS (SYNTHESIS OF 4,10,16,22-TETRAMETHOXYCALIX [4] ARENE FROM ANISE OIL

    Directory of Open Access Journals (Sweden)

    Ratna Ningsih S

    2015-01-01

    Full Text Available One kind of calixarenes, i.e. 4,10,16,22-tetramethoxycalix[4]arene (4, has been synthesized from anethole (1, which was isolated from anise oil. The synthesis of 4 was carried out via acid-catalyzed procedure. The reaction route consists of three stages, i.e. (i oxidation of 1 with KMnO4 at 40oC for 15 minutes, (ii reduction p-anisaldehyde (2 with NaBH4 at 76oC for 3 hours, and  (iii cyclotetramerization of p-anisilalcohol (3 with AlCl3 at 20oC for 2 hours. Oxidation of 1 produced 2 in 77%, whereas reduction of 2 gave 3 in 55 %. The cyclotetramerization of 3 yielded 4 in 95 %.  Key Words: 4,10,16,22-tetramethoxycalix[4]arene, Anise Oil, Anethole

  11. 24 CFR 320.10 - Financial reporting.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Financial reporting. 320.10 Section...-BACKED SECURITIES Pass-Through Type Securities § 320.10 Financial reporting. Issuers shall submit to the Association audited annual financial statements within 90 days of their fiscal year end. All financial...

  12. 10p Duplication characterized by fluorescence in situ hybridization

    Energy Technology Data Exchange (ETDEWEB)

    Wiktor, A.; Feldman, G.L.; Van Dyke, D.L.; Kratkoczki, P.; Ditmars, D.M. Jr. [Henry Ford Hospital, Detroit, MI (United States)

    1994-09-01

    We describe a patient with severe failure to thrive, mild-moderate developmental delay, cleft lip and palate, and other anomalies. Routine cytogenetic analysis documented a de novo chromosome rearrangement involving chromosome 4, but the origin of the derived material was unknown. Using chromosome specific painting probes, the karyotype was defined as 46,XY,der(4)t(4;10)(q35;p11.23). Characterization of the dup(10p) by fluorescence in situ hybridization (FISH) analysis provides another example of the usefulness of this technology in identifying small deletions, duplications, or supernumerary marker chromosomes. 19 refs., 4 figs.

  13. 17 CFR 245.103 - Issuer right of recovery; right of action by equity security owner.

    Science.gov (United States)

    2010-04-01

    ..., conversion or termination of a derivative security) in violation of section 306(a)(1) of that Act of an... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Issuer right of recovery; right of action by equity security owner. 245.103 Section 245.103 Commodity and Securities Exchanges...

  14. Electro-physical properties of a Si-based MIS structure with a low-k SiOC(-H) film

    Energy Technology Data Exchange (ETDEWEB)

    Zakirov, Anvar Sagatovich; Navamathavan, Rangaswamy; Kim, Seung Hyun; Jang, Yong Jun; Jung, An Soo; Choi, Chi Kyu [Cheju National University, Jeju (Korea, Republic of)

    2006-09-15

    SiOC(-H) films with low dielectric constants have been prepared by using plasma enhanced chemical vapor deposition with a mixture of methyltriethoxysilane and oxygen precursors. The C-V characteristics of the structures, Al/SiOC(-H)/p-Si(100), were studied in the forward and the reverse directions by applying a polarizing potential. We found that the ratio of the maximum to the minimum capacitance (C{sub ma}x{sub /}C{sub min}) depended on the [MTES/(MTES+O{sub 2})] flow rate ratio. Annealed samples exhibited even greater reductions of the maximum capacitance and the dielectric constant of the SiOC(-H) samples. After annealing at 400 .deg. C, the measurement in the reverse direction revealed an interesting behavior in the form of strongly pronounced 'steps'. The bonds between Si-O and the -CH{sub 3} group reduced the surface charge density, and the distribution of the surface charge density depended on [MTES/(MTES+O{sub 2})] flow rate ratio and the annealing temperature because the fixed positive (Si-CH{sub 3}){sup +} and negative (Si-O){sup -} changed the configuration at the SiOC(-H)/p-Si(100) interface. The SiOC(-H) film had donor (O{sub 2}) and acceptor (Si-CH{sub 3} -groups) levels, and the electronic process at the SiOC(-H)/p-Si(100) interface was defined by the (Si-CH{sub 3}){sup +} and the (Si-O){sup -} bonds.

  15. International Active Surveillance Study of Women Taking Oral Contraceptives (INAS-OC Study).

    Science.gov (United States)

    Dinger, Juergen C; Bardenheuer, Kristina; Assmann, Anita

    2009-11-18

    will be validated by contacting the relevant physician and by reviewing relevant source documents. At the end of the study an independent blinded adjudication of relevant clinical outcomes will be conducted. Meanwhile, this study has received ethical approval from the Western Institutional Review Board (USA) and the Medical Association in Berlin (Germany). The feasibility of the study is considered to be very high because of its similar design to the EURAS-OC study. All relevant methodological and logistical features of the study were successfully tested in the EURAS study. The chosen design minimizes the impact of referral and misclassification bias, healthy user effect and loss to follow-up. Overall, it is expected that the study design is robust enough to interpret hazard ratios of 1.5 or higher.

  16. 76 FR 64075 - Membership of the National Telecommunications and Information Administration's Performance Review...

    Science.gov (United States)

    2011-10-17

    ... Human Resources Operations Center (DOCHROC), Office of Staffing, Recruitment, and Classification.... Karl B. Nebbia, Associate Administrator for Spectrum Management, Career SES. Alan W. Vincent, Associate... Human Resources Operations Center. [FR Doc. 2011-26736 Filed 10-14-11; 8:45 am] BILLING CODE 3510-25-P ...

  17. 19 CFR 10.175 - Imported directly defined.

    Science.gov (United States)

    2010-04-01

    ... imported directly only if they: (1) Remained under the control of the customs authority of the intermediate... 19 Customs Duties 1 2010-04-01 2010-04-01 false Imported directly defined. 10.175 Section 10.175 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE...

  18. 19 CFR 210.73 - Review of reports.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Review of reports. 210.73 Section 210.73 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Enforcement Procedures and Advisory Opinions § 210.73 Review of reports. (a...

  19. 76 FR 4716 - Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Off Delaware, Notice of...

    Science.gov (United States)

    2011-01-26

    ... No. BOEM-2010-0075] Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Off... commercial wind development on the OCS off Delaware and requests submission of indications of competitive... received two nominations of proposed lease areas: One from Bluewater Wind Delaware LLC (Bluewater) and...

  20. 78 FR 52562 - Outer Continental Shelf (OCS), Gulf of Mexico (GOM), Oil and Gas Lease Sales, Central Planning...

    Science.gov (United States)

    2013-08-23

    ... Prepare a Supplemental Environmental Impact Statement (EIS). SUMMARY: Consistent with the regulations... Supplemental EIS will update the environmental and socioeconomic analyses in the Gulf of Mexico OCS Oil and Gas... Area Lease Sales 227, 231, 235, 241, and 247, Final Environmental Impact Statement (OCS EIS/EA BOEM...

  1. Turkeyen Campus, P.O. Box 10 1110, Georgetown, Guyana (S ...

    African Journals Online (AJOL)

    a

    K values) for Fe(III) and Cr(III) complexes, respectively, at 35 oC and ionic strength 0.1 M. KEY WORDS: Paper ... A study on the feasibility of controlling the level of iron(III) and chromium(III) metal ions by ... 10-3 M. Metal spots were detected on the paper using potassium ferrocyanide solution (BDH, Poole,. UK) for Fe(III) and ...

  2. 77 FR 36257 - Notice of Implementation of Determination Under Section 129 of the Uruguay Round Agreements Act...

    Science.gov (United States)

    2012-06-18

    ... (``Divella''), Pasta Zara SpA 1 and Pasta Zara SpA 2 (collectively, ``Pasta Zara''), Pastificio Di Martino... Antidumping Duty Administrative Review, 75 FR 11116 (March 10, 2010). Divella,\\10\\ Pasta Zara, Certain Pasta... Pasta from Italy (2006/07) F. Divella S.p.A 2.83 0.00 Pasta Zara S.p.A. 1 and Pasta Zara 9.71 0.00 S.p.A...

  3. Constraining the 19Ne(p,γ)20Na Reaction Rate Using a Direct Measurement at DRAGON

    Science.gov (United States)

    Wilkinson, R.; Lotay, G.; Lennarz, A.; Ruiz, C.; Christian, G.; Akers, C.; Catford, W. N.; Chen, A. A.; Connolly, D.; Davids, B.; Hutcheon, D. A.; Jedrejcic, D.; Laird, A. M.; Martin, L.; McNeice, E.; Riley, J.; Williams, M.

    2018-01-01

    A direct measurement of the 19Ne(p, γ)20 Na reaction has been performed in inverse kinematics at the DRAGON recoil separator, at an energy ˜ 10 keV higher than previous measurements. The key resonance in the 19 Ne + p system relevant for ONe novae and Type-I X-ray burst temperatures have been successfully measured for the first time. Preliminary estimates of the resonance energy and strength are reported as Ec.m. ≈ 458 keV and ωγ ≈ 18 meV. These results are consistent with previous direct measurements, but disagree with the most recent study of the 19Ne(p, γ)20 Na reaction rate. These preliminary results will be finalised after a forthcoming negative log-likelihood analysis.

  4. REMOTE SENSING OF CH4 BY COMBINING LIDAR AND OPTICAL CORRELATION SPECTROSCOPY : FIRST EXPERIMENTAL RESULTS B. Thomas1, A. Miffre1, G. David1, J.P. Cariou2, P. Rairoux1 1Laboratoire de Spectrométrie Ionique et Moléculaire, CNRS, UMR 5579 Université Lyon 1, 10 rue Ada Byron, 69622 Villeurbanne, France, patrick.rairoux@univ-lyon1.fr 2Leosphere France, 14-16 rue Jean Rostand, 91400 Orsay, France, jpcariou@leosphere.fr

    Science.gov (United States)

    Thomas, B.; Miffre, A.; David, G.; Cariou, J.; Rairoux, P.

    2012-12-01

    In this contribution, we present a new methodology, called OCS-lidar, to remotely evaluate trace gas concentrations in the atmosphere (B. Thomas et al, 2012), as well as the first methane concentration measurements using this methodology. It is based on combining the Optical Correlation Spectroscopy (OCS) method with laser remote sensing technique (lidar). As displayed on figure 1, an Acoustic Optical Programmable Dispersive Filter is coupled with spectrally broadened femtosecond laser pulses to achieve the optical correlation between the emitted laser pulse and the methane absorption cross-section. In a first time, statistical and systematical errors of the OCS-lidar methodology have been evaluated thanks to a numerical model. The detection noise, interfering trace gases, temperature and pressure variations as well as laser pulse-to-pulse fluctuations have been considered. OCS-lidar simulations for methane concentration measurements have been achieved for background concentration (1.5 to 3 ppm), low (tens of ppm) and high sources (hundreds of ppm). Results show that background measurements are possible in the hour range while sources assessment and localization can be achieved in 10 minutes range up to 3 km range. Then, first methane concentration experimental measurements by using the OCS-lidar methodology will be presented. The laser source is an Oscillator Parametric Amplifier with emitting wavelength from 1.1 to 2 μm with 0.2 mJ at 1 kHz repetition rate. An AOPDF is used to generate correlated and non-correlated (or reference) signal. Experimental results on background methane concentration and on remote point source measurements will be presented, showing the achieved sensitivity and accuracy in both geophysical conditions.igure 1. Scheme of the OCS-Lidar principle. A broadened laser source centered on λ0-wavelength, with power spectral density P0, is used to create spectrally shaped power density P0M1 and P0M2, which are respectively correlated and anti

  5. 75 FR 73085 - National Toxicology Program (NTP): Office of Liaison, Policy, and Review; Availability of Draft...

    Science.gov (United States)

    2010-11-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Toxicology Program (NTP): Office of Liaison... Materials The agenda topic is the peer review of the findings and conclusions of draft NTP TRs of toxicology.... Bucher, Associate Director, National Toxicology Program. [FR Doc. 2010-29945 Filed 11-26-10; 8:45 am...

  6. 77 FR 66075 - Agency Information Collection Activities; Emergency Clearance Submission for Expedited OMB Review...

    Science.gov (United States)

    2012-11-01

    ... Ethics. [FR Doc. 2012-26101 Filed 10-31-12; 8:45 am] BILLING CODE 6345-03-P ... OFFICE OF GOVERNMENT ETHICS Agency Information Collection Activities; Emergency Clearance... 201-A Ethics in Government Act Access Form AGENCY: Office of Government Ethics (OGE). ACTION...

  7. Isotope effect in the carbonyl sulfide reaction with O(3P)

    DEFF Research Database (Denmark)

    Hattori, Shohei; Schmidt, Johan Albrecht; Mahler, Denise W.

    2012-01-01

    The sulfur kinetic isotope effect (KIE) in the reaction of carbonyl sulfide (OCS) with O((3)P) was studied in relative rate experiments at 298 ± 2 K and 955 ± 10 mbar. The reaction was carried out in a photochemical reactor using long path FTIR detection, and data were analyzed using a nonlinear...... least-squares spectral fitting procedure with line parameters from the HITRAN database. The ratio of the rate of the reaction of OC(34)S relative to OC(32)S was found to be 0.9783 ± 0.0062 ((34)e = (-21.7 ± 6.2)‰). The KIE was also calculated using quantum chemistry and classical transition state theory......; at 300 K, the isotopic fractionation was found to be (34)e = -14.8‰. The OCS sink reaction with O((3)P) cannot explain the large fractionation in (34)S, over +73‰, indicated by remote sensing data. In addition, (34)e in OCS photolysis and OH oxidation are not larger than 10‰, indicating that...

  8. 19 CFR 10.7 - Substantial containers or holders.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Substantial containers or holders. 10.7 Section 10... Exported and Returned § 10.7 Substantial containers or holders. (a) Substantial containers or holders... domestic products exported and returned. When such containers or holders are imported not containing or...

  9. 19 CFR 146.10 - Authority to examine merchandise.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Authority to examine merchandise. 146.10 Section 146.10 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.10 Authority to examine...

  10. 78 FR 64242 - Outer Continental Shelf (OCS), Gulf of Mexico (GOM), Oil and Gas Lease Sales, Western Planning...

    Science.gov (United States)

    2013-10-28

    ... (NOA) of the Draft Supplemental Environmental Impact Statement (EIS) and Public Meetings. SUMMARY: BOEM... Impact Statement (OCS EIS/EA BOEM 2012-019) (2012- 2017 WPA/CPA Multisale EIS) and in the Gulf of Mexico... Lease Sale 231, Final Supplemental Environmental Impact Statement (OCS EIS/EA BOEM 2013-0118) (WPA 233...

  11. 19 CFR 10.3 - Drawback; internal-revenue tax.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Drawback; internal-revenue tax. 10.3 Section 10.3... and Returned § 10.3 Drawback; internal-revenue tax. (a) Except as prescribed in § 10.1(f) or in... tax is imposed on the importation of like articles not previously exported from the United States or...

  12. 78 FR 36604 - Proposed Collection; Comment Request

    Science.gov (United States)

    2013-06-18

    ... calculation: 3970 equity issuers + 131 bond issuers = 4101 total issuers. See World Federation of Exchanges... (providing number of equity issuers listed on Canada's Toronto Stock Exchange in 2012). After 2009, the World... issuers listed on Canada's Toronto Stock Exchange in 2009 (111) relative to the number of bonds listed on...

  13. 19 CFR 10.18 - Valuation of assembled articles.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Valuation of assembled articles. 10.18 Section 10... THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles Assembled Abroad with United States Components § 10.18 Valuation of assembled articles. As in the case of...

  14. 19 CFR 10.9 - Articles exported for processing.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles exported for processing. 10.9 Section 10... THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles Exported and Returned § 10.9 Articles exported for processing. (a) Except as otherwise provided for in this...

  15. Cytoarchitecture of the human lateral occipital cortex: mapping of two extrastriate areas hOc4la and hOc4lp.

    Science.gov (United States)

    Malikovic, Aleksandar; Amunts, Katrin; Schleicher, Axel; Mohlberg, Hartmut; Kujovic, Milenko; Palomero-Gallagher, Nicola; Eickhoff, Simon B; Zilles, Karl

    2016-05-01

    The microstructural correlates of the functional segregation of the human lateral occipital cortex are largely unknown. Therefore, we analyzed the cytoarchitecture of this region in ten human post-mortem brains using an observer-independent and statistically testable parcellation method to define the position and extent of areas in the lateral occipital cortex. Two new cytoarchitectonic areas were found: an anterior area hOc4la and a posterior area hOc4lp. hOc4la was located behind the anterior occipital sulcus in rostral and ventral portions of this region where it occupies the anterior third of the middle and inferior lateral occipital gyri. hOc4lp was found in caudal and dorsal portions of this region where it extends along the superior and middle lateral occipital gyri. The cytoarchitectonic areas were registered to 3D reconstructions of the corresponding brains, which were subsequently spatially normalized to the Montreal Neurological Institute reference space. Continuous probabilistic maps of both areas based on the analysis of ten brains were generated to characterize their inter-subject variability in location and size. The maps of hOc4la and hOc4lp were then used as seeds for meta-analytic connectivity modeling and quantitative functional decoding to identify their co-activation patterns and assignment to functional domains. Convergent evidence from their location, topography, size, functional domains and connectivity indicates that hOc4la and hOc4lp are the potential anatomical correlates of the functionally defined lateral occipital areas LO-1 and LO-2.

  16. 10 CFR 1045.19 - Accountability for classification and declassification determinations.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Accountability for classification and declassification determinations. 1045.19 Section 1045.19 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION....19 Accountability for classification and declassification determinations. (a) Whenever a...

  17. International Active Surveillance Study of Women Taking Oral Contraceptives (INAS-OC Study

    Directory of Open Access Journals (Sweden)

    Assmann Anita

    2009-11-01

    baseline. Self-reported serious adverse events will be validated by contacting the relevant physician and by reviewing relevant source documents. At the end of the study an independent blinded adjudication of relevant clinical outcomes will be conducted. Meanwhile, this study has received ethical approval from the Western Institutional Review Board (USA and the Medical Association in Berlin (Germany. Discussion The feasibility of the study is considered to be very high because of its similar design to the EURAS-OC study. All relevant methodological and logistical features of the study were successfully tested in the EURAS study. The chosen design minimizes the impact of referral and misclassification bias, healthy user effect and loss to follow-up. Overall, it is expected that the study design is robust enough to interpret hazard ratios of 1.5 or higher.

  18. 78 FR 76178 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2013-12-16

    ... provide investors, and the subject issuer with information about accumulations of equity securities that... national security, trade secrets, or privileged commercial or financial information. An agency may not... Copies Available From: Securities and Exchange Commission, Office of Investor Education and Advocacy...

  19. 75 FR 47282 - Notice of Proposed Information Collection Requests

    Science.gov (United States)

    2010-08-05

    .... Office of Postsecondary Education Type of Review: New. Title: Application for Grants under the Talent... under the Talent Search (TS) Program. The Department is requesting a new application because of the... Service (FIRS) at 1-800-877-8339. [FR Doc. 2010-19301 Filed 8-4-10; 8:45 am] BILLING CODE 4000-01-P ...

  20. Poole-Frenkel behavior in amorphous oxide thin-film transistors prepared on SiOC

    International Nuclear Information System (INIS)

    Oh, Teresa

    2014-01-01

    The electron behavior in amorphous indium-gallium-zinc-oxide thin film transistors (a-IGZO TFTs) depends on the polar characteristics of SiOC, which is used as a gate dielectric. The properties of the interface between the semiconductor and SiOC were defined by using a Schottky contact with a low potential barrier and Poole-Frenkel contacts with a high potential barrier. The leakage current of SiOC, which was used as a gate insulator, decreased at the Poole-Frenkel contacts because of the high potential barrier. The ambipolar properties in the field effect transistor were observed to depend on the various characteristics of SiOC, which ranged from its behaving as an ideal insulator or as a material with a high dielectric constant. The resistance of the a-IGZO channel changed from positive to negative at SiOC, which had the lowest polarity. As to the conduction due to the diffusion current, the mobility increased with increasing carrier concentrations. However, the drift carrier conduction was related to the reduced mobility at higher carrier concentrations. The performance of the transistors was enhanced by the tunneling and the diffusion currents Rather than by the drift current caused by trapping. The Schottky contact and the Poole-Frenkel (PF) contacts at an interface between the IGZO channel and the SiOC were defined according to the heights of potential barriers caused by the depletion layer. The leakage current was very low about 10 -12 A at SiOC with PF contacts because of the height of potential barrier was double that with a Schottky contact because the tunneling conductance due to the diffusion current originated from the PF contacts of non-polar SiOC.

  1. Poole-Frenkel behavior in amorphous oxide thin-film transistors prepared on SiOC

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Teresa [Cheongju University, Cheongju (Korea, Republic of)

    2014-05-15

    The electron behavior in amorphous indium-gallium-zinc-oxide thin film transistors (a-IGZO TFTs) depends on the polar characteristics of SiOC, which is used as a gate dielectric. The properties of the interface between the semiconductor and SiOC were defined by using a Schottky contact with a low potential barrier and Poole-Frenkel contacts with a high potential barrier. The leakage current of SiOC, which was used as a gate insulator, decreased at the Poole-Frenkel contacts because of the high potential barrier. The ambipolar properties in the field effect transistor were observed to depend on the various characteristics of SiOC, which ranged from its behaving as an ideal insulator or as a material with a high dielectric constant. The resistance of the a-IGZO channel changed from positive to negative at SiOC, which had the lowest polarity. As to the conduction due to the diffusion current, the mobility increased with increasing carrier concentrations. However, the drift carrier conduction was related to the reduced mobility at higher carrier concentrations. The performance of the transistors was enhanced by the tunneling and the diffusion currents Rather than by the drift current caused by trapping. The Schottky contact and the Poole-Frenkel (PF) contacts at an interface between the IGZO channel and the SiOC were defined according to the heights of potential barriers caused by the depletion layer. The leakage current was very low about 10{sup -12} A at SiOC with PF contacts because of the height of potential barrier was double that with a Schottky contact because the tunneling conductance due to the diffusion current originated from the PF contacts of non-polar SiOC.

  2. 19 CFR 10.76 - Game animals and birds.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Game animals and birds. 10.76 Section 10.76... TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Animals and Birds § 10.76 Game animals and birds. (a) The following classes of live game animals and birds may be...

  3. 17 CFR 210.3-10 - Financial statements of guarantors and issuers of guaranteed securities registered or being...

    Science.gov (United States)

    2010-04-01

    ... substantially duplicate disclosure elsewhere in the parent company's consolidated financial statements; and (12) Where the parent company's consolidated financial statements are prepared on a comprehensive basis other... included elsewhere in the reconciliation of the consolidated financial statements. [65 FR 51707, Aug. 24...

  4. File list: Unc.PSC.50.AllAg.P19 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.P19 mm9 Unclassified Pluripotent stem cell P19 SRX1098121,SRX10981...20,SRX1098122,SRX1098124,SRX1098123,SRX1098125 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.P19.bed ...

  5. File list: Unc.PSC.05.AllAg.P19 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.05.AllAg.P19 mm9 Unclassified Pluripotent stem cell P19 SRX1098120,SRX10981...23,SRX1098121,SRX1098122,SRX1098125,SRX1098124 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.05.AllAg.P19.bed ...

  6. File list: Unc.PSC.20.AllAg.P19 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.P19 mm9 Unclassified Pluripotent stem cell P19 SRX1098121,SRX10981...20,SRX1098123,SRX1098122,SRX1098124,SRX1098125 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.20.AllAg.P19.bed ...

  7. 78 FR 56251 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting...

    Science.gov (United States)

    2013-09-12

    ... in corporate debt securities and Agency Debt Securities \\8\\ and certain primary market transactions... Rule 6710(m). As FINRA notes, Section 201 of the Jumpstart Our Business Startups Act (the ``JOBS Act... the same issuer or similarly-rated issuers. \\10\\ Public Law 112-106, 126 Stat. 306. \\11\\ See Notice...

  8. Card Product Use and Perception of Marketing Communication by Card Issuers among Students

    Directory of Open Access Journals (Sweden)

    Đurđana Ozretić Došen

    2011-06-01

    Full Text Available Student population is a very interesting and important segment of the market to the marketing practitioners involved in card business. The services and products offered by card issuers to students are created with a view to attracting the kind of users who will grow accustomed to a long-term, loyal use of a chosen card brand, i.e. beyond the point at which they complete their academic education. This paper describes the exploratory research on card products designed for the student population which was conducted in the Republic of Croatia. Student awareness of card products and their habits associated with card use were also examined. Additional areas of research were student attitudes and perceptions with regard to card products and to the appeal of the marketing communications which target this specific market segment. Results showed that the majority of students hold debit cards of the banks in which they have their current accounts. Students use cards actively, most of all for the purpose of withdrawing cash at automated teller machines (ATMs and least of all for Internet purchases. They assess card use as being simple, and card holders are also aware of the various benefits provided through it. However, the recall of advertisements for card products point to the conclusion that card issuers do not communicate with students in a manner which the latter would find appealing.

  9. [Characteristics and sources apportionment of OC and EC in PM1.1 from Nanjing].

    Science.gov (United States)

    Jiang, Wen-juan; Guo, Zhao-bing; Liu, Feng-ling; Rui, Mao-ling; Shi, Lei; Zeng, Gang; Guo, Zi-yan

    2015-03-01

    The concentrations of OC and EC in PM1.1 collected from Nanshi (NS) and Nanhua (NH) in 2011 were analyzed using DRI Model 2001A Thermal Optical Carbon Analyzer. In addition, source apportionment was simultaneously evaluated. The results showed that the annual average concentrations of OC and EC in PM1.1 were 10. 10 μg x m(-3) and 2.52 μg x m(-3) in NS area, and 11.22 μg x m(-3) and 3.12 μg x m(-3) in NH area, respectively. This result indicated that OC and EC pollution in NH was more serious than that in NS area. Meanwhile, the concentrations of OC and EC in winter and spring were obviously higher compared to those in summer in these two sampling sites, which was mainly ascribed to the increased coal combustion and the unfavorable emission condition of air pollutants in summer and spring. We noted that the SOC/TOC value was the highest in summer and the lowest in winter. In addition, the SOC concentration was observed to show a positive correlation with ozone concentrations, which indicated that the photochemical reaction was a main way of SOC formation in autumn.

  10. Test of the Zweig rule in. pi. /sup -/p interactions at 19 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Woodworth, P L; Treille, D; Thompson, A S; Strub, R; Sonderegger, P; Palazzi-Cerrina, C; Mitaroff, W A; French, B R [European Organization for Nuclear Research, Geneva (Switzerland); Kumar, R [Glasgow Univ. (UK). Dept. of Natural Philosophy; Kenyon, I R [Birmingham Univ. (UK). Dept. of Physics

    1976-10-25

    Phi production has been observed in ..pi../sup -/p interactions at 19 GeV/c with (44+-10) events in the final state phi..pi../sup +/..pi../sup -/..pi../sup -/p and (45+-9) events in phiK/sup +/K/sup -/..pi../sup -/p. The production ratios phi..pi../sup +/..pi../sup -/..pi../sup -/p/..omega pi../sup +/..pi../sup -/..pi../sup -/p approximately 0.005 and phiK/sup +/K/sup -/..pi../sup -/p/rho/sup 0/K/sup +/K/sup -/..pi../sup -/p approximately 0.45 agree with Zweig-rule expectations.

  11. 77 FR 69543 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-11-19

    ... exercise of the right to call that is different from the issuer's determination. Affected Public: Private... development credit election is in effect. Affected Public: Private Sector: Business or other for-profits... update Pub. 1212, List of Original Issue Discount Instruments. Affected Public: Private Sector: Business...

  12. Human parvovirus B19: a review.

    Science.gov (United States)

    Rogo, L D; Mokhtari-Azad, T; Kabir, M H; Rezaei, F

    2014-01-01

    Parvovirus B19 (B19V) is a small non-enveloped single-stranded DNA (ssDNA) virus of the family Parvoviridae, the subfamily Parvovirinae, the genus Erythrovirus and Human parvovirus B19 type species. It is a common community-acquired respiratory pathogen without ethnic, socioeconomic, gender, age or geographic boundaries. Moreover, the epidemiological and ecological relationships between human parvovirus B19, man and environment have aroused increasing interest in this virus. B19V infection is associated with a wide spectrum of clinical manifestations, some of which were well established and some are still controversial, however, it is also underestimated from a clinical perspective. B19V targets the erythroid progenitors in the bone marrow by binding to the glycosphingolipid globoside (Gb4), leading to large receptor-induced structural changes triggering cell death either by lysis or by apoptosis mediated by the nonstructural (NS)1 protein. The pattern of genetic evolution, its peculiar properties and functional profile, the characteristics of its narrow tropism and restricted replication, its complex relationship with the host and its ample pathogenetic potential are all topics that are far from a comprehensive understanding. The lack of efficient adaptation to in vitro cellular cultures and the absence of animal models have limited classical virological studies and made studies on B19V dependent on molecular biology. The present review looks at the nature of this virus with the view to provide more information about its biology, which may be useful to the present and future researchers. human parvovirus B19; respiratory pathogen; biology; genome; fifth disease; transient aplastic crisis; anemia.

  13. Reactivity of Cubane-Type [(OC)(3)MFe(3)S(4)(SR)(3)](3-) Clusters (M = Mo, W): Interconversion with Cuboidal [Fe(3)S(4)](0) Clusters and Electron Transfer.

    Science.gov (United States)

    Raebiger, James W.; Crawford, Charles A.; Zhou, Jian; Holm, R. H.

    1997-03-12

    The title clusters, several examples of which have been reported earlier, have been prepared by two different methods and subjected to structural and reactivity studies. The compounds (Et(4)N)(3)[(OC)(3)MFe(3)S(4)(Smes)(3)].MeCN (M = Mo/W) are isomorphous and crystallize in monoclinic space group P2(1)/n with a = 13.412(1)/13.297(1) Å, b = 19.0380(1)/18.9376(3) Å, c = 26.4210(1)/26.2949(1) Å, beta = 97.87(1)/97.549(1) degrees, and Z = 4. The clusters contain long M-S (2.62/2.59 Å) and M-Fe (3.22/3.19 Å) bonds, consistent with the reported structure of [(OC)(3)MoFe(3)S(4)(SEt)(3)](3-) (3). Reaction of [(OC)(3)MoFe(3)S(4)(LS(3))](3-) (7) with CO in the presence of NaPF(6) affords cuboidal [Fe(3)S(4)(LS(3))](3-) (9), also prepared in this laboratory by another route as a synthetic analogue of protein-bound [Fe(3)S(4)](0) clusters. The clusters [Fe(3)S(4)(SR)(3)](3-) (R = mes, Et), of limited stability, were generated by the same reaction. Treatment of 9 with [M(CO)(3)(MeCN)(3)] affords 7 and its M = W analogue. The clusters [(OC)(3)MFe(3)S(4)(SR)(3)](3-) form a four-member electron transfer series in which the 3- cluster can be once reduced (4-) and twice oxidized (2-, 1-) to afford clusters of the indicated charges. The correct assignment of redox couple to potential in the redox series of six clusters is presented, correcting an earlier misassignment of the redox series of 3. Carbonyl stretching frequencies are shown to be sensitive to cluster oxidation state, showing that the M sites and Fe(3)S(4) fragments are electronically coupled despite the long bond distances. (LS(3) = 1,3,5-tris((4,6-dimethyl-3-mercaptophenyl)thio)-2,4,6-tris(p-tolylthio)benzenate(3-); mes = mesityl.)

  14. 78 FR 52206 - Center For Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-08-22

    ...: Biophysics, Biochemistry and Chemistry. Date: September 18-19, 2013. Time: 8:00 a.m. to 3:00 p.m. Agenda: To..., Bethesda, MD 20892 (Virtual Meeting). Contact Person: John L Bowers, Ph.D., Scientific Review Officer..., Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701...

  15. 10 CFR 19.15 - Consultation with workers during inspections.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Consultation with workers during inspections. 19.15...: INSPECTION AND INVESTIGATIONS § 19.15 Consultation with workers during inspections. (a) Commission inspectors... inspectors deem necessary for the conduct of an effective and thorough inspection. (b) During the course of...

  16. 77 FR 27746 - Notice of Submission for OMB Review; Federal Student Aid; Lender Application Process (LAP)

    Science.gov (United States)

    2012-05-11

    ... Records Management Services, Office of Management, publishes this notice containing proposed information..., Information Collection Clearance Division, Privacy, Information and Records Management Services, Office of Management. [FR Doc. 2012-11378 Filed 5-10-12; 8:45 am] BILLING CODE 4000-01-P ...

  17. 19 CFR 10.46 - Articles for the United States.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles for the United States. 10.46 Section 10... THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles for Institutions § 10.46 Articles for the United States. Pursuant to subheadings 9808.00.10 and 9808...

  18. Asperger syndrome in a boy with a balanced de novo translocation: t(17;19)(p13.3;p11)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-10

    The cause of Asperger syndrome is unknown. It is classified as a form of childhood autism. Familial aggregation in infantile autism has been reported. Asperger syndrome has also been considered as being genetically transmitted and certain of its characteristics have tended to occur in other relatives, especially in the fathers. We describe a 10-year-old boy with a clinical diagnosis of Asperger syndrome and a balanced de novo translocation (t(17;19)9p13.3;p11). His parents are not consanguineous and are healthy, as are his three brothers. 5 refs.

  19. Measurement of the fluorine content of three NBS standard reference materials by use of the /sup 19/F(p, p'. gamma. )/sup 19/F reaction

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, A L; Kraner, H W; Shroy, R E; Jones, K W [Brookhaven National Lab., Upton, NY (USA)

    1984-08-01

    The fluorine contents of National Bureau of Standards (NBS) Standard Reference Materials (SRM) 91, opal glass; 120b, phosphate rock; and 2671a, freeze-dried urine; have been measured using the /sup 19/F(p,p'..gamma..)/sup 19/F reaction at a proton energy of 3.1 MeV. The results are in good agreement with the values certified by the NBS.

  20. 76 FR 30956 - Outer Continental Shelf, Alaska OCS Region, Chukchi Sea Planning Area, Oil and Gas Lease Sale 193

    Science.gov (United States)

    2011-05-27

    ... Point Hope et al., v. Salazar, No. 1:08-cv-00004-RRB (D. Alaska)]. The sale was conducted in February... Continental Shelf, Alaska OCS Region, Chukchi Sea Planning Area, Oil and Gas Lease Sale 193 AGENCY: Bureau of...: BOEMRE announces the availability of a Revised Draft SEIS, OCS Oil and Gas Lease Sale 193, Chukchi Sea...

  1. 75 FR 30915 - Computer Matching Program Between the Department of Veterans Affairs (VA) and the Department of...

    Science.gov (United States)

    2010-06-02

    ... FR 29275 (June 19, 2009), and last amended at 75 FR (April 27, 2010). e. Inclusive dates of the...:30 p.m., Monday through Friday (except holidays). Please call (202) 461-4902 for an appointment...

  2. Jaktar på gåtene til universet

    CERN Multimedia

    Toft, Martin

    2004-01-01

    50 år har fysikarar frå 80 land og 500 universitet frå heile verda kome saman ved Det europeiske laboratoriet for partikkelfysikk (CERN) for å få testa ut teoriane sine i praksis. Forskinga på CERN har resultert i to Nobelprisar i fysikk og i verdsveven. Den 19. oktober feira laboratoriet 50-årsjubileet med Frankrikes president Jacques Chirac og Spanias kong Juan Carlos som dei mest kjende gjestene. Uniforum har besǿkt partikkelfysikarane sitt templ i Genève

  3. 77 FR 2100 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-01-13

    ... issuer of a security that the broker-dealer is trying to sell to or buy from a customer must give the customer written notification disclosing the control relationship at or before completion of the... and Exchange Commission (``Commission'') has submitted to the Office of Management and Budget (``OMB...

  4. 19 CFR 173.1 - Authority to review for error.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Authority to review for error. 173.1 Section 173.1 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) ADMINISTRATIVE REVIEW IN GENERAL § 173.1 Authority to review for error. Port directors...

  5. Soil water content plays an important role in soil-atmosphere exchange of carbonyl sulfide (OCS)

    Science.gov (United States)

    Yi, Zhigang; Behrendt, Thomas; Bunk, Rüdiger; Wu, Dianming; Kesselmeier, Jürgen

    2016-04-01

    Carbonyl sulfide (OCS) is a quite stable gas in the troposphere and is transported up to the stratosphere, where it contributes to the sulfate aerosol layer (Crutzen 1976). The tropospheric concentration seems to be quite constant, indicating a balance between sinks and sources. Recent work by Sandoval-Soto et al. (2005) demonstrated the enormous strength of the vegetation sink and the urgent needs to understand the sinks and sources. The role of soils is a matter of discussion (Kesselmeier et al., 1999; Van Diest and Kesselmeier, 2008; Maseyk et al., 2014; Whelan et al., 2015). To better understand the influence of soil water content and OCS mixing ratio on OCS fluxes, we used an OCS analyzer (LGR COS/CO Analyzer 907-0028, Los Gatos, CA, USA) coupled with automated soil chamber system (Behrendt et al., 2014) to measure the OCS fluxes with a slow drying of four different types of soil (arable wheat soil in Mainz, blueberry soil in Waldstein, spruce soil in Waldstein and needle forest soil in Finland). Results showed that OCS fluxes as well as the optimum soil water content for OCS uptake varied significantly for different soils. The net production rates changed significantly with the soil drying out from 100% to about 5% water holding capacity (WHC), implying that soil water content play an important role in the uptake processes. The production and uptake processes were distinguished by the regression of OCS fluxes under different OCS mixing ratios. OCS compensation points (CP) were found to differ significantly for different soil types and water content, with the lowest CP at about 20% WHC, implying that when estimating the global budgets of OCS, especially for soils fluxes, soil water content should be taken into serious consideration. References Crutzen, P. J. 1976, Geophys. Res. Lett., 3, 73-76. Sandoval-Soto, L. et al., 2005, Biogeosciences, 2, 125-132. Kesselmeier, J. et al., 1999, J. Geophys. Res., 104, 11577-11584. Van Diest, H. and Kesselmeier, J. 2008

  6. 19 CFR 10.625 - Refunds of excess customs duties.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Refunds of excess customs duties. 10.625 Section 10.625 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... and Apparel Goods § 10.625 Refunds of excess customs duties. (a) Applicability. Section 205 of the...

  7. Sequence Ready Characterization of the Pericentromeric Region of 19p12

    Energy Technology Data Exchange (ETDEWEB)

    Evan E. Eichler

    2006-08-31

    Current mapping and sequencing strategies have been inadequate within the proximal portion of 19p12 due, in part, to the presence of a recently expanded ZNF (zinc-finger) gene family and the presence of large (25-50 kb) inverted beta-satellite repeat structures which bracket this tandemly duplicated gene family. The virtual of absence of classically defined “unique” sequence within the region has hampered efforts to identify and characterize a suitable minimal tiling path of clones which can be used as templates required for finished sequencing of the region. The goal of this proposal is to develop and implement a novel sequence-anchor strategy to generate a contiguous BAC map of the most proximal portion of chromosome 19p12 for the purpose of complete sequence characterization. The target region will be an estimated 4.5 Mb of DNA extending from STS marker D19S450 (the beginning of the ZNF gene cluster) to the centromeric (alpha-satellite) junction of 19p11. The approach will entail 1) pre-selection of 19p12 BAC and cosmid clones (NIH approved library) utilizing both 19p12 -unique and 19p12-SPECIFIC repeat probes (Eichler et al., 1998); 2) the generation of a BAC/cosmid end-sequence map across the region with a density of one marker every 8kb; 3) the development of a second-generation of STS (sequence tagged sites) which will be used to identify and verify clonal overlap at the level of the sequence; 4) incorporation of these sequence-anchored overlapping clones into existing cosmid/BAC restriction maps developed at Livermore National Laboratory; and 5) validation of the organization of this region utilizing high-resolution FISH techniques (extended chromatin analysis) on monochromosomal 19 somatic cell hybrids and parental cell lines of source material. The data generated will be used in the selection of the most parsimonious tiling path of BAC clones to be sequenced as part of the JGI effort on chromosome 19 and should serve as a model for the sequence

  8. 75 FR 28665 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-05-21

    ... securityholders' ownership of an issue of securities for which it performs transfer agent functions, including the... principal dollar amount of debt securities that the issuer has authorized to be outstanding (a ``control... maintain and keep current an accurate record of the number of shares or principal dollar amount of debt...

  9. Autism and ADHD Symptoms in Patients with OCD: Are They Associated with Specific OC Symptom Dimensions or OC Symptom Severity?

    Science.gov (United States)

    Anholt, Gideon E.; Cath, Danielle C.; van Oppen, Patricia; Eikelenboom, Merijn; Smit, Johannes H.; van Megen, Harold; van Balkom, Anton J. L. M.

    2010-01-01

    In obsessive-compulsive disorder (OCD), the relationship between autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder (ADHD) symptom, and obsessive-compulsive (OC) symptom dimensions and severity has scarcely been studied. Therefore, 109 adult outpatients with primary OCD were compared to 87 healthy controls on OC, ADHD and…

  10. 7 CFR 43.105 - Operating characteristics (OC) curves.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Operating characteristics (OC) curves. 43.105 Section 43.105 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... CONTAINER REGULATIONS STANDARDS FOR SAMPLING PLANS Sampling Plans § 43.105 Operating characteristics (OC...

  11. 19 CFR 10.814 - Direct costs of processing operations.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Direct costs of processing operations. 10.814... Free Trade Agreement Rules of Origin § 10.814 Direct costs of processing operations. (a) Items included. For purposes of § 10.810(b) of this subpart, the words “direct costs of processing operations”, with...

  12. 19 CFR 10.774 - Direct costs of processing operations.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Direct costs of processing operations. 10.774... Free Trade Agreement Rules of Origin § 10.774 Direct costs of processing operations. (a) Items included. For purposes of § 10.770(b) of this subpart, the words “direct costs of processing operations”, with...

  13. 77 FR 62273 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-10-12

    ... data requirement is to make financial information easier for investors to analyze and assist issuers in... Act of 1934 (15 U.S.C. 78a et seq.) to submit specified financial information to the Commission and... 249.240f and 17 CFR 249.306). In interactive data format, financial statement information could be...

  14. Direct mapping of 19F in 19FDG-6P in brain tissue at subcellular resolution using soft X-ray fluorescence

    Science.gov (United States)

    Poitry-Yamate, C.; Gianoncelli, A.; Kourousias, G.; Kaulich, B.; Lepore, M.; Gruetter, R.; Kiskinova, M.

    2013-10-01

    Low energy x-ray fluorescence (LEXRF) detection was optimized for imaging cerebral glucose metabolism by mapping the fluorine LEXRF signal of 19F in 19FDG, trapped as intracellular 19F-deoxyglucose-6-phosphate (19FDG-6P) at 1μm spatial resolution from 3μm thick brain slices. 19FDG metabolism was evaluated in brain structures closely resembling the general cerebral cytoarchitecture following formalin fixation of brain slices and their inclusion in an epon matrix. 2-dimensional distribution maps of 19FDG-6P were placed in a cytoarchitectural and morphological context by simultaneous LEXRF mapping of N and O, and scanning transmission x-ray (STXM) imaging. A disproportionately high uptake and metabolism of glucose was found in neuropil relative to intracellular domains of the cell body of hypothalamic neurons, showing directly that neurons, like glial cells, also metabolize glucose. As 19F-deoxyglucose-6P is structurally identical to 18F-deoxyglucose-6P, LEXRF of subcellular 19F provides a link to in vivo 18FDG PET, forming a novel basis for understanding the physiological mechanisms underlying the 18FDG PET image, and the contribution of neurons and glia to the PET signal.

  15. Direct mapping of 19F in 19FDG-6P in brain tissue at subcellular resolution using soft X-ray fluorescence

    International Nuclear Information System (INIS)

    Poitry-Yamate, C; Lepore, M; Gruetter, R; Gianoncelli, A; Kourousias, G; Kiskinova, M; Kaulich, B

    2013-01-01

    Low energy x-ray fluorescence (LEXRF) detection was optimized for imaging cerebral glucose metabolism by mapping the fluorine LEXRF signal of 19 F in 19 FDG, trapped as intracellular 19 F-deoxyglucose-6-phosphate ( 19 FDG-6P) at 1μm spatial resolution from 3μm thick brain slices. 19 FDG metabolism was evaluated in brain structures closely resembling the general cerebral cytoarchitecture following formalin fixation of brain slices and their inclusion in an epon matrix. 2-dimensional distribution maps of 19 FDG-6P were placed in a cytoarchitectural and morphological context by simultaneous LEXRF mapping of N and O, and scanning transmission x-ray (STXM) imaging. A disproportionately high uptake and metabolism of glucose was found in neuropil relative to intracellular domains of the cell body of hypothalamic neurons, showing directly that neurons, like glial cells, also metabolize glucose. As 19 F-deoxyglucose-6P is structurally identical to 18 F-deoxyglucose-6P, LEXRF of subcellular 19 F provides a link to in vivo 18 FDG PET, forming a novel basis for understanding the physiological mechanisms underlying the 18 FDG PET image, and the contribution of neurons and glia to the PET signal

  16. 17 CFR 239.34 - Form F-4, for registration of securities of foreign private issuers issued in certain business...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Form F-4, for registration of securities of foreign private issuers issued in certain business combination transactions. 239.34 Section 239.34 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION FORMS PRESCRIBED UNDER THE...

  17. 77 FR 66625 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-11-06

    ... Trend in Child Maltreatment. Date: November 19, 2012. Time: 12:00 p.m. to 1:00 p.m. Agenda: To review... Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393-93.396, 93.837-93.844, 93.846-93.878...

  18. Trophic transfer of persistent organochlorine contaminants (OCs) within an Arctic marine food web from the southern Beaufort-Chukchi Seas

    International Nuclear Information System (INIS)

    Hoekstra, P.F.; O'Hara, T.M.; Fisk, A.T.; Borgaa, K.; Solomon, K.R.; Muir, D.C.G.

    2003-01-01

    The trophic status and biomagnification of persistent OCs within the near-shore Beaufort-Chukchi Seas food web from Barrow, AK is discussed. - Stable isotope values (δ 13 C, δ 15 N) and concentrations of persistent organochlorine contaminants (OCs) were determined to evaluate the near-shore marine trophic status of biota and biomagnification of OCs from the southern Beaufort-Chukchi Seas (1999-2000) near Barrow, AK. The biota examined included zooplankton (Calanus spp.), fish species such as arctic cod (Boreogadus saida), arctic char (Salvelinus alpinus), pink salmon (Oncorhynchus gorbuscha), and fourhorn sculpin (Myoxocephalus quadricornis), along with marine mammals, including bowhead whales (Balaena mysticetus), beluga whales (Delphinapterus leucas), ringed seals (Phoca hispida) and bearded seals (Erignathus barbatus). The isotopically derived trophic position of biota from the Beaufort-Chukchi Seas marine food web, avian fauna excluded, is similar to other coastal food webs in the Arctic. Concentrations of OCs in marine mammals were significantly greater than in fish and corresponded with determined trophic level. In general, OCs with the greatest food web magnification factors (FWMFs) were those either formed due to biotransformation (e.g. p,p'-DDE, oxychlordane) or considered recalcitrant (e.g. β-HCH, 2,4,5-Cl substituted PCBs) in most biota, whereas concentrations of OCs that are considered to be readily eliminated (e.g. γ-HCH) did not correlate with trophic level. Differences in physical-chemical properties of OCs, feeding strategy and possible biotransformation were reflected in the variable biomagnification between fish and marine mammals. The FWMFs in the Beaufort-Chukchi Seas region were consistent with reported values in the Canadian Arctic and temperate food webs, but were statistically different than FWMFs from the Barents and White Seas, indicating that the spatial variability of OC contamination in top-level marine Arctic predators is

  19. 47 CFR 76.10 - Review.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Review. 76.10 Section 76.10 Telecommunication... TELEVISION SERVICE General § 76.10 Review. (a) Interlocutory review. (1) Except as provided below, no party may seek review of interlocutory rulings until a decision on the merits has been issued by the staff...

  20. 10 CFR 95.19 - Changes to security practices and procedures.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Changes to security practices and procedures. 95.19 Section 95.19 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FACILITY SECURITY CLEARANCE AND..., also to the Director, Division of Security Operations, Office of Nuclear Security and Incident Response...

  1. 75 FR 80300 - Five-Year Review of Oil Pipeline Pricing Index

    Science.gov (United States)

    2010-12-22

    ...] Five-Year Review of Oil Pipeline Pricing Index Issued December 16, 2010. AGENCY: Federal Energy... five-year review of the oil pricing index, established in Order No. 561. After consideration of the... period commencing July 1, 2011. \\1\\ Five-Year Review of Oil Pipeline Pricing Index, 75 FR 34959 (June 21...

  2. Determination of primary combustion source organic carbon-to-elemental carbon (OC / EC ratio using ambient OC and EC measurements: secondary OC-EC correlation minimization method

    Directory of Open Access Journals (Sweden)

    C. Wu

    2016-05-01

    Full Text Available Elemental carbon (EC has been widely used as a tracer to track the portion of co-emitted primary organic carbon (OC and, by extension, to estimate secondary OC (SOC from ambient observations of EC and OC. Key to this EC tracer method is to determine an appropriate OC / EC ratio that represents primary combustion emission sources (i.e., (OC / ECpri at the observation site. The conventional approaches include regressing OC against EC within a fixed percentile of the lowest (OC / EC ratio data (usually 5–20 % or relying on a subset of sampling days with low photochemical activity and dominated by local emissions. The drawback of these approaches is rooted in its empirical nature, i.e., a lack of clear quantitative criteria in the selection of data subsets for the (OC / ECpri determination. We examine here a method that derives (OC / ECpri through calculating a hypothetical set of (OC / ECpri and SOC followed by seeking the minimum of the coefficient of correlation (R2 between SOC and EC. The hypothetical (OC / ECpri that generates the minimum R2(SOC,EC then represents the actual (OC / ECpri ratio if variations of EC and SOC are independent and (OC / ECpri is relatively constant in the study period. This Minimum R Squared (MRS method has a clear quantitative criterion for the (OC / ECpri calculation. This work uses numerically simulated data to evaluate the accuracy of SOC estimation by the MRS method and to compare with two commonly used methods: minimum OC / EC (OC / ECmin and OC / EC percentile (OC / EC10 %. Log-normally distributed EC and OC concentrations with known proportion of SOC are numerically produced through a pseudorandom number generator. Three scenarios are considered, including a single primary source, two independent primary sources, and two correlated primary sources. The MRS method consistently yields the most accurate SOC estimation. Unbiased SOC estimation by OC

  3. Effects of ultraviolet irradiation treatment on low-k SiOC(-H) ultra-thin films deposited by using TMS/O2 PEALD

    International Nuclear Information System (INIS)

    Kim, Changyoung; Woo, Jongkwan; Choi, Chikyu; Navamathavan, R.

    2012-01-01

    We report on the electrical characteristics for the metal-insulator-semiconductor (MIS) structure of low-dielectric-constant SiOC(-H) films. The SiOC(-H) thin films were deposited on p-Si(100) substrates by using a plasma-enhanced atomic layer deposition (PEALD) system. To improve the structural and the electrical characteristics, we post-treated the SiOC(-H) films deposited using PEALD with ultraviolet (UV) irradiation for various time intervals. The radical intensities in the bulk plasma were observed to be influenced strongly by the radio-frequency (rf) power. A complete dissociation of the trimethylsilane (TMS) precursor took place for rf powers greater than 300 W. As the UV treatment time was increased, the bonding structure of the SiOC(-H) film clearly separated to Si-O-Si and Si-O-C bonds. Also, the fixed charge density and the interface state density on the SiOC(-H)/p-Si(100) interface decreased as the UV treatment time was increased to 6 min. Therefore, we were able to minimize the defects and to reduce the interface charge by adjusting the UV dose.

  4. 77 FR 24734 - Outer Continental Shelf (OCS) Renewable Energy Program Leasing for Marine Hydrokinetic Technology...

    Science.gov (United States)

    2012-04-25

    ... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management [Docket No. BOEM-2012-0011] Outer Continental Shelf (OCS) Renewable Energy Program Leasing for Marine Hydrokinetic Technology Testing Offshore Florida AGENCY: Bureau of Ocean Energy Management, Interior. ACTION: Notice of the Availability of an...

  5. A review of (e,e'p) data from Saclay

    International Nuclear Information System (INIS)

    Le Goff, J.M.; Bernheim, M.; Danel, J.F.; Jackson, H.E.; Meziani, Z.E.

    1993-01-01

    The last (e,e'p) results from the Saclay are reviewed. They include searches for a possible modification of the nucleon form factor when embedded in nuclear medium, this is 40 Ca and few-body nuclei; and also studies of two-body properties through the measurement of high proton momenta in 3 He and 4 He. The new electron facilities might open on these topics. (authors) 19 refs., 5 figs

  6. Variations in the OM/OC ratio of urban organic aerosol next to a major roadway.

    Science.gov (United States)

    Brown, Steven G; Lee, Taehyoung; Roberts, Paul T; Collett, Jeffrey L

    2013-12-01

    Understanding the organic matter/organic carbon (OM/OC) ratio in ambient particulate matter (PM) is critical to achieve mass closure in routine PM measurements, to assess the sources of and the degree of chemical processing organic aerosol particles have undergone, and to relate ambient pollutant concentrations to health effects. Of particular interest is how the OM/OC ratio varies in the urban environment, where strong spatial and temporal gradients in source emissions are common. We provide results of near-roadway high-time-resolution PM1 OM concentration and OM/OC ratio observations during January 2008 at Fyfe Elementary School in Las Vegas, NV, 18 m from the U.S. 95 freeway soundwall, measured with an Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-AMS). The average OM/OC ratio was 1.54 (+/- 0.20 standard deviation), typical of environments with a low amount of secondary aerosol formation. The 2-min average OM/OC ratios varied between 1.17 and 2.67, and daily average OM/OC ratios varied between 1.44 and 1.73. The ratios were highest during periods of low OM concentrations and generally low during periods of high OM concentrations. OM/OC ratios were low (1.52 +/- 0.14, on average) during the morning rush hour (average OM = 2.4 microg/m3), when vehicular emissions dominate this near-road measurement site. The ratios were slightly lower (1.46 +/- 0.10) in the evening (average OM = 6.3 microg/m3), when a combination of vehicular and fresh residential biomass burning emissions was typically present during times with temperature inversions. The hourly averaged OM/OC ratio peaked at 1.66 at midday. OM concentrations were similar regardless of whether the monitoring site was downwind or upwind of the adjacent freeway throughout the day, though they were higher during stagnant conditions (wind speed < 0.5 m/sec). The OM/OC ratio generally varied more with time of day than with wind direction and speed.

  7. Thermal-Conductivity Studies of Macro-porous Polymer-Derived SiOC Ceramics

    Science.gov (United States)

    Qiu, L.; Li, Y. M.; Zheng, X. H.; Zhu, J.; Tang, D. W.; Wu, J. Q.; Xu, C. H.

    2014-01-01

    A three-dimensional reticular macro-porous SiOC ceramics structure, made of spherical agglomerates, has been thermally characterized using a freestanding sensor-based method. The effective thermal conductivity of the macro-porous SiOC ceramics, including the effects of voids, is found to be to at room temperature, comparable with that of alumina aerogel or carbon aerogel. These results suggest that SiOC ceramics hold great promise as a thermal insulation material for use at high temperatures. The measured results further reveal that the effective thermal conductivity is limited by the low solid-phase volume fraction for the SiOC series processed at the same conditions. For SiOC ceramics processed under different pyrolysis temperatures, the contact condition between neighboring particles in the SiOC networks is another key factor influencing the effective thermal conductivity.

  8. Physicochemical Characterization and Skin Permeation of Cationic Transfersomes Containing the Synthetic Peptide PnPP-19.

    Science.gov (United States)

    Almeida, Flavia De Marco; Silva, Carolina Nunes; de Araujo Lopes, Savia Caldeira; Santos, Daniel Moreira; Torres, Fernanda Silva; Cardoso, Felipe Lima; Martinelli, Patricia Massara; da Silva, Elizabeth Ribeiro; de Lima, Maria Elena; Miranda, Lucas Antonio Ferreira; Oliveira, Monica Cristina

    2018-01-08

    PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded transfersomes. Three different liposomal preparation methods were evaluated. Cationic transfersomes contained egg phosphatidyl choline: stearylamine (9:1 w/w) and Tween 20 (84.6:15.4 lipid:Tween, w/w). Lipid concentration varied from 20 to 40 mM. We evaluated the entrapment percentage, mean diameter, zeta potential and stability at 4 oC of the formulations. The skin permeation assays were performed with abdominal human skin using Franz diffusion cell with 3 cm2 diffusion area at 32 oC and a fluorescent derivative of the peptide, containing 5-TAMRA, bound to PnPP-19 C-terminal region, where an extra lysine was inserted. Our results showed variable entrapment efficiencies, from 6% to 30%, depending on the preparation method and the lipid concentration used. The reverse phase evaporation method using a total lipid concentration equal to 40 mM led to the best entrapment percentage (30.2 + 4.5%). Free PnPP-19 was able to permeate skin at a rate of 10.8 ng/cm2/h. However, PnPP-19 was specifically hydrolyzed by skin proteases, generating a fragment of 15 amino acid residues. Encapsulated PnPP-19 permeated the skin at a rate of 19.8 ng/cm2/h. The encapsulation of PnPP-19 in cationic transfersomes protected the peptide from degradation, favoring its topical administration. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  9. Compte rendu partiel du 10e Colloque sur l'Exploitation des Océans, Paris, 20-22 janvier 1982 Partial Report on the 10th Symposium on Ocean Exploitation, Paris, 20-22 January 1982

    Directory of Open Access Journals (Sweden)

    Bertrand A. R. V.

    2006-11-01

    Full Text Available De ce 10e Colloque de l' ASTEO sur l'exploitation des océans (Paris, 20-22 janvier 1982 nous retiendrons les points suivants : - la reconnaissance unanime du rôle primordial joué par le secteur pétrolier dans l'exploitation des richesse océaniques ; - la grande qualité des communications consacrées à l'exploitation pétrolière marine. On retiendra aussi une excellente table ronde consacrée aux sources d'énergie utilisables en propulsion sous-marine et susceptibles de menacer le quasi monopole des classique batteries au plomb. Les batteries évoluées, dont le développement industriel coûterait trop cher en l'absence de débouchés commerciaux suffisants (le marché de la traction électrique automobile paraissant leur échapper, semblent abandonnées. Les piles à combustible à hydrogène et à électrolyte basique (type IFP et les moteurs Stirling à stockage thermique se présentaient comme les meilleures solutions de remplacement. Mais un conférencier a créé la surprise en présentant un moteur diesel en circuit fermé qui a été certifié par Lloyds Register et dont on parle pour équiper le sous-marin Argyronète. This 10th ASTEO Symposium on Ocean Exploitation (Paris, 20-22 January 1982 concentrated on the following two points: (i unanimous recognition of the primordial rote played by the petroleum sector in exploiting the wealth contained in the ocean, and (ii the high quality of the papers devoted to offshore petroleum operations. There was also an excellent round-table discussion devoted to energy sources that can be used for subsea propulsion and that might act as a threat to the quasi-monopoly of conventional lead batteries. So-called sophisticated batteries, for which industrial development would be too expensive in the absence of a sufficient potential market (since the market for electric automotive traction appears to be beyond their reach, appear to have been abandoned. Hydrogen and basic electrolyte fuel cells

  10. The p16INK4alpha/p19ARF gene mutations are infrequent and are mutually exclusive to p53 mutations in Indian oral squamous cell carcinomas.

    Science.gov (United States)

    Kannan, K; Munirajan, A K; Krishnamurthy, J; Bhuvarahamurthy, V; Mohanprasad, B K; Panishankar, K H; Tsuchida, N; Shanmugam, G

    2000-03-01

    Eighty-seven untreated primary oral squamous cell carcinomas (SCCs) associated with betel quid and tobacco chewing from Indian patients were analysed for the presence of mutations in the commonly shared exon 2 of p16INK4alpha/p19ARF genes. Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and sequencing analysis were used to detect mutations. SSCP analysis indicated that only 9% (8/87) of the tumours had mutation in p16INK4alpha/p19ARF genes. Seventy-two tumours studied here were previously analysed for p53 mutations and 21% (15/72) of them were found to have mutations in p53 gene. Only one tumour was found to have mutation at both p53 and p16INK4alpha/p19ARF genes. Thus, the mutation rates observed were 21% for p53, 9% for p16INK4alpha/p19ARF, and 1% for both. Sequencing analysis revealed two types of mutations; i) G to C (GCAG to CCAG) transversion type mutation at intron 1-exon 2 splice junction and ii) another C to T transition type mutation resulting in CGA to TGA changing arginine to a termination codon at p16INK4alpha gene codon 80 and the same mutation will alter codon 94 of p19ARF gene from CCG to CTG (proline to leucine). These results suggest that p16INK4alpha/p19ARF mutations are less frequent than p53 mutations in Indian oral SCCs. The p53 and p16INK4alpha/p19ARF mutational events are independent and are mutually exclusive suggesting that mutational inactivation of either p53 or p16INK4alpha/p19ARF may alleviate the need for the inactivation of the other gene.

  11. Atmospheric carbonyl sulfide (OCS measured remotely by FTIR solar absorption spectrometry

    Directory of Open Access Journals (Sweden)

    G. C. Toon

    2018-02-01

    Full Text Available Atmospheric OCS abundances have been retrieved from infrared spectra measured by the Jet Propulsion Laboratory (JPL MkIV Fourier transform infra-red (FTIR spectrometer during 24 balloon flights and during nearly 1100 days of ground-based observations since 1985. Our spectral fitting approach uses broad windows to enhance the precision and robustness of the retrievals. Since OCS has a vertical profile similar in shape to that of N2O, and since tropospheric N2O is very stable, we reference the OCS observations to those of N2O, measured simultaneously in the same air mass, to remove the effects of stratospheric transport, allowing a clearer assessment of secular changes in OCS. Balloon measurements reveal less than 5 % change in stratospheric OCS amounts over the past 25 years. Ground-based measurements reveal a springtime peak of tropospheric OCS, followed by a rapid early-summer decrease, similar to the behavior of CO2. This results in a peak-to-peak seasonal cycle of 5–6 % of the total OCS column at northern mid-latitudes. In the long-term tropospheric OCS record, a 5 % decrease is seen from 1990 to 2002, followed by a 5 % increase from 2003 to 2012.

  12. Total hemispherical emissivity of pre-oxidized and un-oxidized Zr-2.5Nb pressure-tube materials at 600 {sup o}C to 1000 {sup o}C under vacuum

    Energy Technology Data Exchange (ETDEWEB)

    Fong, R.W.L.; Paine, M.; Nitheanandan, T., E-mail: randy.fong@cnl.ca [Canadian Nuclear Laboratories, Chalk River, Ontario (Canada)

    2016-06-15

    The emissivity of pre-oxidized and un-oxidized pressure-tube specimens has been measured at high temperatures under vacuum. The emissivity values of un-oxidized tube specimens decreased only slightly from 0.34 at 600 {sup o}C to 0.30 at 800 {sup o}C and changed gradually to 0.25 at 1000 {sup o}C. In comparison, the emissivity of pre-oxidized pressure-tube specimens decreased drastically from 0.70 at 600 {sup o}C to 0.35 at 800 {sup o}C, and gradually decreased to 0.25 at 1000 {sup o}C. The oxide layer of the pre-oxidized tube specimens dissolved into the metal matrix when heated to 700 {sup o}C and higher. Using these results, 2 linear correlations were obtained for emissivity with the oxide thickness measured by scanning electron microscopy and secondary ion mass spectroscopy analysis. (author)

  13. 10 CFR 150.19 - Submission to Commission of tritium reports.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Submission to Commission of tritium reports. 150.19... Agreement States § 150.19 Submission to Commission of tritium reports. (a)-(b) [Reserved] (c) Except as... authorized to possess tritium shall report promptly to the appropriate NRC Regional Office as shown in...

  14. Spin correlations in the pyrochlore slab compounds Ba2Sn2Ga10-7pZnCr7pO22

    International Nuclear Information System (INIS)

    Bonnet, P; Payen, C; Mutka, H; Danot, M; Fabritchnyi, P; Stewart, J R; Mellergaard, A; Ritter, C

    2004-01-01

    The low-temperature properties of a diluted antiferromagnetic pyrochlore slab of S = 3/2 spins are investigated through a study of the frustrated oxides Ba 2 Sn 2 Ga 10-7p ZnCr 7p O 22 (p>0.85). Powder neutron diffraction and 119 Sn Moessbauer absorption show no evidence of long-range magnetic order above 1.5 K. As in SrCr 9q Ga 12-9q O 19 , diffuse magnetic scattering, indicative of short range spin-spin correlations, is observed at low temperature. The dependence of the low-temperature sub-Curie bulk susceptibility to weak site depletion is the inverse of that observed in SrCr 9q Ga 12-9q O 19

  15. 17 CFR 270.19b-1 - Frequency of distribution of capital gains.

    Science.gov (United States)

    2010-04-01

    ... eligible trust security which adversely affects the ability of such issuer to continue payment of principal... which adversely affects the ability of such issuer to continue payment of principal or interest on its... request as not being necessary or appropriate in the public interest or for the protection of investors...

  16. Size Effect Studies of the Creep Behaviour of 20MnMoNi55 at Temperatures from 700 {sup o}C to 900 {sup o}C

    Energy Technology Data Exchange (ETDEWEB)

    Krompholz, K.; Groth, E.; Kalkhof, D

    2000-11-01

    One of the objectives of the REVISA project (REactor Vessel Integrity in Severe Accidents) is to assess size and scale effects in plastic flow and failure. This includes an experimental programme devoted to characterising the influence of specimen size, strain rate, and strain gradients at various temperatures. One of the materials selected was the forged reactor pressure vessel material 20 MnMoNi 55, material number 1.6310 (heat number 69906). Among others, a size effect study of the creep response of this material was performed, using geometrically similar smooth specimens with 5 mm and 20 mm diameter. The tests were done under constant load in an inert atmosphere at 700 {sup o}C, 800 {sup o}C, and 900 {sup o}C, close to and within the phase transformation regime. The mechanical stresses varied from 10 MPa to 30 MPa, depending on temperature. Prior to creep testing the temperature and time dependence of scale oxidation as well as the temperature regime of the phase transformation was determined. The creep tests were supplemented by metallographical investigations.The test results are presented in form of creep curves strain versus time from which characteristic creep data were determined as a function of the stress level at given temperatures. The characteristic data are the times to 5% and 15% strain and to rupture, the secondary (minimum) creep rate, the elongation at fracture within the gauge length, the type of fracture and the area reduction after fracture. From metallographical investigations the austenitic phase contents at different temperatures could be estimated. From these data also the parameters of the regression calculation (e.g. Norton's creep law) were obtained. The evaluation revealed that the creep curves and characteristic data are size dependent of varying degree, depending on the stress and temperature level, but the size influence cannot be related to corrosion or orientation effects or to macroscopic heterogeneity (position effect) of

  17. 19 CFR 10.537 - Accessories, spare parts, or tools.

    Science.gov (United States)

    2010-04-01

    ... parts, or tools will be taken into account as originating or non-originating materials, as the case may... 19 Customs Duties 1 2010-04-01 2010-04-01 false Accessories, spare parts, or tools. 10.537 Section... Free Trade Agreement Rules of Origin § 10.537 Accessories, spare parts, or tools. Accessories, spare...

  18. Paediatric B-cell precursor acute lymphoblastic leukaemia with t(1;19)(q23;p13): clinical and cytogenetic characteristics of 47 cases from the Nordic countries treated according to NOPHO protocols

    DEFF Research Database (Denmark)

    Andersen, Mette Klarskov; Autio, Kirsi; Barbany, Gisela

    2011-01-01

    The translocation t(1;19)(q23;p13)/der(19)t(1;19) is a risk stratifying aberration in childhood B-cell precursor acute lymphoblastic leukaemia (BCP ALL) in the Nordic countries. We have identified 47 children/adolescents with t(1;19)/der(19)t(1;19)-positive BCP ALL treated on two successive Nordic...... Society of Paediatric Haematology and Oncology (NOPHO) protocols between 1992 and 2007 and have reviewed the clinical and cytogenetic characteristics of these cases, comprising 1·8% of all cases. The translocation was balanced in 15 cases (32%) and unbalanced in 29 cases (62%). The most common additional...... and 10 years was 0·85 and 0·82, respectively. Nine patients had a bone marrow relapse after a median of 23 months; no patient had a central nervous system relapse. Additional cytogenetic abnormalities, age, gender, WBC count or whether the t(1;19) was balanced or unbalanced did not influence EFS or OS...

  19. 76 FR 18812 - Submission for Review: RI 30-10, Disabled Dependent Questionnaire

    Science.gov (United States)

    2011-04-05

    ... OFFICE OF PERSONNEL MANAGEMENT Submission for Review: RI 30-10, Disabled Dependent Questionnaire... Dependent Questionnaire. As required by the Paperwork Reduction Act of 1995 (Pub. L. 104-13, 44 U.S.C... (202) 606-0910. SUPPLEMENTARY INFORMATION: The RI 30-10, Disabled Dependent Questionnaire, is used to...

  20. 76 FR 36582 - Submission for Review: Disabled Dependent Questionnaire, RI 30-10

    Science.gov (United States)

    2011-06-22

    ... OFFICE OF PERSONNEL MANAGEMENT Submission for Review: Disabled Dependent Questionnaire, RI 30-10... Dependent Questionnaire. As required by the Paperwork Reduction Act of 1995 (Pub. L. 104-13, 44 U.S.C.... SUPPLEMENTARY INFORMATION: RI 30-10, Disabled Dependent Questionnaire, is used to collect sufficient information...

  1. The neurological mouse mutations jittery and hesitant are allelic and map to the region of mouse chromosome 10 homologous to 19p13.3

    Energy Technology Data Exchange (ETDEWEB)

    Kapfhamer, D.; Sufalko, D.; Warren, S. [Univ. of Michigan, Ann Arbor, MI (United States)] [and others

    1996-08-01

    Jittery (ji) is a recessive mouse mutation on Chromosome 10 characterized by progressive ataxic gait, dystonic movements, spontaneus seizures, and death by dehydration/starvation before fertility. Recently, a viable neurological recessive mutation, hesitant, was discovered. It is characterized by hesitant, uncoordinated movements, exaggerated stepping of the hind limbs, and reduced fertility in males. In a complementation test and by genetic mapping we have shown here that hesitant and jittery are allelic. Using several large intersubspecific backcrosses and intercrosses we have genetically mapped ji near the marker Amh and microsatellite markers D10Mit7, D10Mit21, and D10Mit23. The linked region of mouse Chromosome 10 is homologous to human 19p13.3, to which several human ataxia loci have recently been mapped. By excluding genes that map to human 21q22.3 (Pfkl) and 12q23 (Nfyb), we conclude that jittery is not likely to be a genetic mouse model for human Unverricht-Lundborg progressive myoclonus epilepsy (EPM1) on 21q22.3 nor for spinocerebellar ataxia II (SCA2) on 12q22-q24. The closely linked markers presented here will facilitate positional cloning of the ji gene. 31 refs., 2 figs.

  2. MicroRNA-17-5p post-transcriptionally regulates p21 expression in irradiated betel quid chewing-related oral squamous cell carcinoma cells

    International Nuclear Information System (INIS)

    Wu, S.Y.; HungKuang Univ., Taichung; Lin, K.C.; Chiou, J.F.; Taipei Medical Univ. Hospital, Taipei; Taipei Medical Univ. Hospital, Taipei; Taipei Medical Univ. Hospital, Taipei; Jeng, S.C.; Cheng, W.H.; Chang, C.I.; Lin, W.C.; Wu, L.L.; Lee, H.L.; Chen, R.J.

    2013-01-01

    Background and purpose: Betel nut chewing is associated with oral cavity cancer in Taiwan. OC3 is an oral carcinoma cell line that was established from cells collected from a long-term betel nut chewer who does not smoke. After we found that microRNA-17-5p (miR-17-5p) is induced in OC3 cells, we used this cell line to examine the biological role(s) of this microRNA in response to exposure to ionizing radiation. Materials and methods: A combined SYBR green-based real-time PCR and oligonucleotide ligation assay was used to examine the expression of the miR-17 polycistron in irradiated OC3 cells. The roles of miR-17-5p and p21 were evaluated with specific antisense oligonucleotides (ODN) that were designed and used to inhibit their expression. Expression of the p21 protein was evaluated by Western blotting. The clonogenic assay and annexin V staining were used to evaluate cell survival and apoptosis, respectively. Cells in which miR-17-5p was stably knocked down were used to create ectopic xenografts to evaluate in vivo the role of miR-17-5p. Results: A radiation dose of 5 Gy significantly increased miR-17-5p expression in irradiated OC3 cells. Inhibition of miR-17-5p expression enhanced the radiosensitivity of the OC3 cells. We found that miR-17-5p downregulates radiation-induced p21 expression in OC3 cells and, by using a tumor xenograft model, it was found that p21 plays a critical role in increasing the radiosensitivity of OC3 cells in vitro and in vivo. Conclusion: miR-17-5p is induced in irradiated OC3 cells and it downregulates p21 protein expression, contributing to the radioresistance of OC3 cells. (orig.)

  3. MicroRNA-17-5p post-transcriptionally regulates p21 expression in irradiated betel quid chewing-related oral squamous cell carcinoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Wu, S.Y. [Taipei Medical Univ., Wan Fang Hospital, Taipei (China). Dept. of Radiation-Oncology; HungKuang Univ., Taichung (China). Dept. of Biotechnology; Lin, K.C. [Taipei Medical Univ., Wan Fang Hospital, Taipei (China). Dept. of Oral and Maxillofacial Surgery; Chiou, J.F. [Taipei Medical Univ., Taipei (China). Dept. of Radiology; Taipei Medical Univ. Hospital, Taipei (China). Dept. of Radiation Oncology; Taipei Medical Univ. Hospital, Taipei (China). Dept. of Hospice and Palliative Center; Taipei Medical Univ. Hospital, Taipei (China). Cancer Center; Jeng, S.C. [Taipei Medical Univ. Hospital, Taipei (China). Dept. of Radiation Oncology; Cheng, W.H.; Chang, C.I. [Taipei Medical Univ., Wan Fang Hospital, Taipei (China). Dept. of Hemato-Ongology; Lin, W.C. [Taipei Medical Univ., Wan Fang Hospital, Taipei (China). Div. of Thoracic Surgery; Wu, L.L. [National Taiwan Univ. Hospital, Taipei (China). Dept. of Ophthalmology; Lee, H.L. [Taipei Medical Univ., Wan Fang Hospital, Taipei (China). Dept. of Radiation-Oncology; Chen, R.J. [National Taiwan Univ. Hospital and National Taiwan Univ., Taipei (China). Dept. of Obstetrics and Gynecology

    2013-08-15

    Background and purpose: Betel nut chewing is associated with oral cavity cancer in Taiwan. OC3 is an oral carcinoma cell line that was established from cells collected from a long-term betel nut chewer who does not smoke. After we found that microRNA-17-5p (miR-17-5p) is induced in OC3 cells, we used this cell line to examine the biological role(s) of this microRNA in response to exposure to ionizing radiation. Materials and methods: A combined SYBR green-based real-time PCR and oligonucleotide ligation assay was used to examine the expression of the miR-17 polycistron in irradiated OC3 cells. The roles of miR-17-5p and p21 were evaluated with specific antisense oligonucleotides (ODN) that were designed and used to inhibit their expression. Expression of the p21 protein was evaluated by Western blotting. The clonogenic assay and annexin V staining were used to evaluate cell survival and apoptosis, respectively. Cells in which miR-17-5p was stably knocked down were used to create ectopic xenografts to evaluate in vivo the role of miR-17-5p. Results: A radiation dose of 5 Gy significantly increased miR-17-5p expression in irradiated OC3 cells. Inhibition of miR-17-5p expression enhanced the radiosensitivity of the OC3 cells. We found that miR-17-5p downregulates radiation-induced p21 expression in OC3 cells and, by using a tumor xenograft model, it was found that p21 plays a critical role in increasing the radiosensitivity of OC3 cells in vitro and in vivo. Conclusion: miR-17-5p is induced in irradiated OC3 cells and it downregulates p21 protein expression, contributing to the radioresistance of OC3 cells. (orig.)

  4. CompTIA Network+ Review Guide Exam N10-005

    CERN Document Server

    Ferguson, Bill

    2012-01-01

    Fast, focused review for the latest CompTIA Network+ Exam N10-005 CompTIA's Network+ certification is the leading non-vendor networking certification in the world and has become the standard certification for networking professionals. Make sure you're ready for CompTIA's new Network+ certification (exam N10-005) with this new edition of Sybex's CompTIA Network+ Review Guide. This concise guide is efficiently organized by exam objectives and covers all five exam domains. The book also includes 50 chapter review questions, as well as access to two online practice exams, and much more. It's the p

  5. 75 FR 64752 - Amended Columbia River Basin Fish and Wildlife Program

    Science.gov (United States)

    2010-10-20

    ... Section 4(h) of the Northwest Power Act, the Council has amended its Columbia River Basin Fish and...) 452-5161. Stephen L. Crow, Executive Director. [FR Doc. 2010-26372 Filed 10-19-10; 8:45 am] BILLING...

  6. Structural basis of glycan specificity of P[19] VP8*: Implications for rotavirus zoonosis and evolution.

    Science.gov (United States)

    Liu, Yang; Xu, Shenyuan; Woodruff, Andrew L; Xia, Ming; Tan, Ming; Kennedy, Michael A; Jiang, Xi

    2017-11-01

    Recognition of specific cell surface glycans, mediated by the VP8* domain of the spike protein VP4, is the essential first step in rotavirus (RV) infection. Due to lack of direct structural information of virus-ligand interactions, the molecular basis of ligand-controlled host ranges of the major human RVs (P[8] and P[4]) in P[II] genogroup remains unknown. Here, through characterization of a minor P[II] RV (P[19]) that can infect both animals (pigs) and humans, we made an important advance to fill this knowledge gap by solving the crystal structures of the P[19] VP8* in complex with its ligands. Our data showed that P[19] RVs use a novel binding site that differs from the known ones of other genotypes/genogroups. This binding site is capable of interacting with two types of glycans, the mucin core and type 1 histo-blood group antigens (HBGAs) with a common GlcNAc as the central binding saccharide. The binding site is apparently shared by other P[II] RVs and possibly two genotypes (P[10] and P[12]) in P[I] as shown by their highly conserved GlcNAc-interacting residues. These data provide strong evidence of evolutionary connections among these human and animal RVs, pointing to a common ancestor in P[I] with a possible animal host origin. While the binding properties to GlcNAc-containing saccharides are maintained, changes in binding to additional residues, such as those in the polymorphic type 1 HBGAs may occur in the course of RV evolution, explaining the complex P[II] genogroup that mainly causes diseases in humans but also in some animals.

  7. C/EBPβ represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19Arf

    Science.gov (United States)

    Ewing, SJ; Zhu, S; Zhu, F; House, JS; Smart, RC

    2013-01-01

    CCAAT/enhancer-binding protein-β (C/EBPβ) is a mediator of cell survival and tumorigenesis. When C/EBPβ−/− mice are treated with carcinogens that produce oncogenic Ras mutations in keratinocytes, they respond with abnormally elevated keratinocyte apoptosis and a block in skin tumorigenesis. Although this aberrant carcinogen-induced apoptosis results from abnormal upregulation of p53, it is not known whether upregulated p53 results from oncogenic Ras and its ability to induce p19Arf and/or activate DNA-damage response pathways or from direct carcinogen-induced DNA damage. We report that p19Arf is dramatically elevated in C/EBPβ−/− epidermis and that C/EBPβ represses a p19Arf promoter reporter. To determine whether p19Arf is responsible for the proapoptotic phenotype in C/EBPβ−/− mice, C/EBPβ−/−;p19Arf−/− mice were generated. C/EBPβ−/−;p19Arf−/− mice responded to carcinogen treatment with increased p53 and apoptosis, indicating p19Arf is not essential. To ascertain whether oncogenic Ras activation induces aberrant p53 and apoptosis in C/EBPβ−/− epidermis, we generated K14-ER:Ras; C/EBPβ−/− mice. Oncogenic Ras activation induced by 4-hydroxytamoxifen did not produce increased p53 or apoptosis. Finally, when C/EBPβ−/− mice were treated with differing types of DNA-damaging agents, including alkylating chemotherapeutic agents, they displayed aberrant levels of p53 and apoptosis. These results indicate that C/EBPβ represses p53 to promote cell survival downstream of DNA damage and suggest that inhibition of C/EBPβ may be a target for cancer cotherapy to increase the efficacy of alkylating chemotherapeutic agents. PMID:18636078

  8. Metrology positronic issuers for nuclear medicine in Cuba: current state and development prospects

    International Nuclear Information System (INIS)

    Oropesa Verdecia, Pilar; Serra Águila, Rolando A.; García Rodríguez, Lourdes; Moreno León, Yecenia; Bell Hechavarría, Ailec; Jénez Magaña, Yoel

    2016-01-01

    At work the current state of metrology positronic issuers for nuclear medicine in Cuba is presented. the main achievements in the implementation of measurement standards and issues affecting the uncertainty of measurements at different levels of hierarchy of the existing chain of traceability for determinations of the activity of F-18 and Ga-68 is described, the main radionuclides expected to be used in the short term in PET and PET / CT applications in the country. Immediate prospects development of measurement standards positronic emitters for use in nuclear medicine in Cuba, in particular the possibilities of establishing equivalence between Cuban standards and national and international standards are also set. (author)

  9. Detection sensitivity of fluorine in dental enamel through the 19F(p,psup(')γ)19F reaction

    International Nuclear Information System (INIS)

    Papper, C.S.; Chittleborough, G.; Kennett, S.R.; Chaudhri, M.A.

    1978-01-01

    The total cross sections for production of 109 and 197 keV gamma rays in the reaction 19 F(p,psup(')γ) 19 F have been measured, over a range of energies up to 4.3 MeV. From these cross sections, the thick detection sensitivities for a uniform distribution of fluorine in dental enamel have been calculated

  10. 77 FR 11179 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-02-24

    ... or less than issuers would pay at other exchanges. For instance, derivative securities products and... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-66422; File No. SR-BATS-2012-010] Self... the Securities Exchange Act of 1934 (the ``Act''),\\1\\ and Rule 19b-4 thereunder,\\2\\ notice is hereby...

  11. Environmental components of OCS policy committee recommendations regarding national oil spill prevention and response program

    International Nuclear Information System (INIS)

    Groat, C.G.; Thorman, J.

    1991-01-01

    The Exxon Valdez oil spill of March 24, 1989 resulted in thousands of pages of analytical reports assessing the environmental, organizational, legal, procedural, social, economic, and political aspects of the event. Even though the accident was a transportation incident, it had a major impact on the public and political perception of offshore oil operations. This caused the OCS Policy Committee, which advises the Secretary of the Interior and the Minerals Management Service on Outer Continental Shelf resource development and environmental matters, to undertake a review of the reports for the purpose of developing recommendations to the secretary for improvements in OCS operations that would insure maximum efforts to prevent spills and optimal ability to deal with any that occur. The Committee felt strongly that 'a credible national spill prevention and response program from both OCS and non-OCS oil spills in the marine environment is needed to create the political climate for a viable OCS program.' The report of the Committee described eight essential elements of this program; four of these focused on the environmental aspects of oil spills, calling for (1) adequate characterization of the marine and coastal environment, including both information and analysis, accessible to decision makers, (2) the capacity to restore economic and environmental resources as quickly as possible if damage occurs, (3) a mechanism for research on oil spill impacts, and (4) a meaningful role for all interested and responsible parties, including the public, in as many of these activities as possible, from spill prevention and contingency planning to environmental oversight of ongoing operations and participation in clean-up and restoration activities

  12. 77 FR 32928 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-06-04

    ... DEPARTMENT OF COMMERCE Submission for OMB Review; Comment Request The Department of Commerce will... published on April 11, 2011 (76 FR 20180). The public benefits associated with protection actions for the... alternatives and to complement other information available about the costs, benefits, and impacts of...

  13. 75 FR 19613 - First Administrative Review of Sodium Hexametaphosphate from the People's Republic of China...

    Science.gov (United States)

    2010-04-15

    ... Critical Circumstances, In Part: Certain Lined Paper Products from the People's Republic of China, 71 FR... Administrative Review: Petroleum Wax Candles from the People's Republic of China, 72 FR 52355, 52356 (September... Preliminary Determination of Sales at Less Than Fair Value, Negative Preliminary Determination of Critical...

  14. 42 CFR 405.810 - Review determination.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Review determination. 405.810 Section 405.810....810 Review determination. Subject to the provisions of §§ 405.807 through 405.809, the carrier shall... determination affirming or revising in whole or in part the findings and determination in question. [39 FR 12097...

  15. 76 FR 14681 - Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore Massachusetts...

    Science.gov (United States)

    2011-03-17

    ... No. BOEM-2010-0063] Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore..., Regulation and Enforcement (BOEMRE), Interior. ACTION: Request for Interest (RFI) in Commercial Wind Energy... (BOEMRE) is reopening the comment period on the RFI in Commercial Wind Energy Leasing Offshore...

  16. Forty-Fourth Meeting of the Technical Working Group on Fast Reactors (TWG-FR). Working Material

    International Nuclear Information System (INIS)

    2011-01-01

    The objectives of the meeting were to: - Exchange information on the national programmes on Fast Reactors (FR) and Accelerator Driven Systems (ADS); - Review the progress since the 43rd TWG-FR Annual Meeting, including the status of the actions; - Consider topical technical meeting arrangements for 2012-2013, as well as review FR-related activities included in the IAEA Project&Budget (P&B) biennium 2012-2013; - Review the IAEA’s ongoing information exchange and coordinated research projects in the technical fields relevant to the TWG-FR (FRs and ADS), as well as coordination of the TWG-FR’s activities with other organizations and international initiatives (GIF, INPRO, NEA, ESNII, etc.)

  17. 19 CFR 4.70 - Public Health Service requirements.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Public Health Service requirements. 4.70 Section 4... THE TREASURY VESSELS IN FOREIGN AND DOMESTIC TRADES Foreign Clearances § 4.70 Public Health Service... Public Health Service. [T.D. 00-4, 65 FR 2874, Jan. 19, 2000] ...

  18. Species of Hypholoma (Fr. P. Kumm. (Strophariaceae, Agaricales in Rio Grande do Sul State, Brazil Espécies de Hypholoma (Fr. P. Kumm. (Strophariaceae, Agaricales no Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Vagner Gularte Cortez

    2007-09-01

    Full Text Available Detailed descriptions, illustrations, discussions and a key for identification of the known species of the genus Hypholoma (Fr. P. Kumm. in Rio Grande do Sul state are presented, as well as a revision of the Hypholoma specimens deposited in the Fungi Rickiani collection. Based on the authors' collections and the herbarium revision, the following species were recognized: H. aurantiacum (Cooke Faus, H. ericaeum (Pers.: Fr. Kühner, and H. subviride (Berk. & M.A. Curtis Dennis.Neste trabalho são apresentadas descrições, ilustrações, discussões e chave de identificação para as espécies do gênero Hypholoma (Fr. P. Kumm. conhecidas no estado do Rio Grande do Sul, além de uma revisão do material de Hypholoma depositado na coleção Fungi Rickiani. A partir das coletas realizadas pelos autores, bem como estudo do material depositado nos principais herbários do estado e do país, verificou-se a ocorrência das seguintes espécies: H. aurantiacum (Cooke Faus, H. ericaeum (Pers.: Fr. Kühner e H. subviride (Berk. & M.A. Curtis Dennis.

  19. 19.2% Efficient InP Heterojunction Solar Cell with Electron-Selective TiO2 Contact.

    Science.gov (United States)

    Yin, Xingtian; Battaglia, Corsin; Lin, Yongjing; Chen, Kevin; Hettick, Mark; Zheng, Maxwell; Chen, Cheng-Ying; Kiriya, Daisuke; Javey, Ali

    2014-12-17

    We demonstrate an InP heterojunction solar cell employing an ultrathin layer (∼10 nm) of amorphous TiO 2 deposited at 120 °C by atomic layer deposition as the transparent electron-selective contact. The TiO 2 film selectively extracts minority electrons from the conduction band of p-type InP while blocking the majority holes due to the large valence band offset, enabling a high maximum open-circuit voltage of 785 mV. A hydrogen plasma treatment of the InP surface drastically improves the long-wavelength response of the device, resulting in a high short-circuit current density of 30.5 mA/cm 2 and a high power conversion efficiency of 19.2%.

  20. 19 CFR 123.61 - Baggage arriving in baggage car.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Baggage arriving in baggage car. 123.61 Section... car. An inward foreign manifest on Customs Form 7533 shall be used for all baggage arriving in baggage cars. [T.D. 70-121, 35 FR 8215, May 26, 1970, as amended by T.D. 82-145, 47 FR 35478, Aug. 16, 1982] ...

  1. Field-free molecular orientation of nonadiabatically aligned OCS

    Science.gov (United States)

    Sonoda, Kotaro; Iwasaki, Atsushi; Yamanouchi, Kaoru; Hasegawa, Hirokazu

    2018-02-01

    We investigate an enhancement of the orientation of OCS molecules by irradiating them with a near IR (ω) ultrashort laser pulse for alignment followed by another ultrashort laser pulse for orientation, which is synthesized by a phase-locked coherent superposition of the near IR laser pulse and its second harmonic (2ω). On the basis of the asymmetry in the ejection direction of S3+ fragment ions generated by the Coulomb explosion of multiply charged OCS, we show that the extent of the orientation of OCS is significantly enhanced when the delay between the alignment pulse and the orientation pulse is a quarter or three quarters of the rotational period. The recorded enhanced orientation was interpreted well by a numerical simulation of the temporal evolution of a rotational wave packet prepared by the alignment and orientation pulses.

  2. Sublinear absorption in OCS gas

    International Nuclear Information System (INIS)

    Bogani, F.; Querzoli, R.; Ernst, K.

    1988-01-01

    Sublinear absorption in OCS gas has been experimentally studied in detail by means of an optoacustic technique and transmission measurements. The best fit of the results is obtained by a phenomenological model, that considers the process as the sum of one-and two-photon absorptions

  3. 77 FR 3029 - Twentieth Meeting: RTCA Special Committee 203, Unmanned Aircraft Systems

    Science.gov (United States)

    2012-01-20

    ... Administrative Remarks Review and approve summary from nineteenth plenary meeting Chairperson/Leadership Updates....m. Plenary session Workgroup Back Briefs Other Business Closing Plenary Session Other Business Date..., Business Operations Branch, Federal Aviation Administration. [FR Doc. 2012-1049 Filed 1-19-12; 8:45 am...

  4. 19 CFR 10.233 - Articles eligible for preferential tariff treatment.

    Science.gov (United States)

    2010-04-01

    ... control of the customs authority of the intermediate country; (ii) Did not enter into the commerce of the... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles eligible for preferential tariff treatment. 10.233 Section 10.233 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...

  5. In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins

    NARCIS (Netherlands)

    Otzen, Marleen; Krikken, Arjen M; Ozimek, Paulina Z; Kurbatova, Elena; Nagotu, Shirisha; Veenhuis, Marten; van der Klei, Ida J

    2006-01-01

    The peroxin Pex19p is important for the formation of functional peroxisomal membranes. Here we show that Hansenula polymorpha Pex19p is also required for peroxisome inheritance. Peroxisome inheritance is partly defective when Pex19p farnesylation is blocked, whereas deletion of PEX19 resulted in a

  6. 77 FR 5581 - Submission for Review: Information Collection; Interview Survey Form (INV 10)

    Science.gov (United States)

    2012-02-03

    ... OFFICE OF PERSONNEL MANAGEMENT Submission for Review: Information Collection; Interview Survey Form (INV 10) AGENCY: U.S. Office of Personnel Management. ACTION: 60-Day Notice and request for... request (ICR), Office of Management and Budget (OMB) Control No. 3206-0106, Interview Survey Form (INV 10...

  7. 19 CFR 10.310 - Election to average for motor vehicles.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Election to average for motor vehicles. 10.310... Free Trade Agreement § 10.310 Election to average for motor vehicles. (a) Election. In determining whether a motor vehicle is originating for purposes of the preferences under the Agreement or a Canadian...

  8. 78 FR 27427 - Outer Continental Shelf (OCS) Geological and Geophysical Exploration Activities in the Gulf of...

    Science.gov (United States)

    2013-05-10

    ... timeframe. The activities considered within this PEIS are associated with GOM OCS oil and gas exploration... and NMFS as the PEIS is developed. Background: A variety of G&G techniques are used to characterize... surveys are conducted to: (1) Obtain data for hydrocarbon exploration and production; (2) aid in siting...

  9. Forty-Fifth Annual Meeting of the Technical Working Group on Fast Reactors (TWG-FR). Presentations

    International Nuclear Information System (INIS)

    2012-01-01

    The objectives of the meeting were to: • Exchange information on the national programmes on Fast Reactors (FR) and Accelerator Driven Systems (ADS); • Review the progress since the 44 th TWG-FR Annual Meeting, including the status of the actions; • Consider topical technical meeting arrangements for 2012-2013, as well as review FR-related activities included in the IAEA Programme & Budget (P&B) biennium 2012-2013; • Review the IAEA’s concluded, on-going and planned coordinated research projects in the technical fields relevant to the TWG-FR (FRs and ADS), as well as coordination of the TWG-FR’s activities with other organizations and international initiatives (GIF, INPRO, NEA, ESNII, etc.)

  10. Theory vs. experiment for molecular clusters: Spectra of OCS trimers and tetramers

    Energy Technology Data Exchange (ETDEWEB)

    Evangelisti, Luca [Department of Chemistry, University of Virginia, McCormick Road, Charlottesville, Virginia 22904 (United States); Dipartimento di Chimica “G. Ciamician,” University of Bologna, Via Selmi 2, Bologna 40126 (Italy); Perez, Cristobal; Seifert, Nathan A.; Pate, Brooks H. [Department of Chemistry, University of Virginia, McCormick Road, Charlottesville, Virginia 22904 (United States); Dehghany, M.; Moazzen-Ahmadi, N. [Department of Physics and Astronomy, University of Calgary, 2500 University Drive North West, Calgary, Alberta T2N 1N4 (Canada); McKellar, A. R. W. [National Research Council of Canada, Ottawa, Ontario K1A 0R6 (Canada)

    2015-03-14

    All singly substituted {sup 13}C, {sup 18}O, and {sup 34}S isotopomers of the previously known OCS trimer are observed in natural abundance in a broad-band spectrum measured with a chirped-pulse Fourier transform microwave spectrometer. The complete substitution structure thus obtained critically tests (and confirms) the common assumption that monomers tend to retain their free structure in a weakly bound cluster. A new OCS trimer isomer is also observed, and its structure is determined to be barrel-shaped but with the monomers all approximately aligned, in contrast to the original trimer which is barrel-shaped with two monomers aligned and one anti-aligned. An OCS tetramer spectrum is assigned for the first time, and the tetramer structure resembles an original trimer with an OCS monomer added at the end with two sulfur atoms. Infrared spectra observed in the region of the OCS ν{sub 1} fundamental (≈2060 cm{sup −1}) are assigned to the same OCS tetramer, and another infrared band is tentatively assigned to a different tetramer isomer. The experimental results are compared and contrasted with theoretical predictions from the literature and from new cluster calculations which use an accurate OCS pair potential and assume pairwise additivity.

  11. Tunneling Characteristics Depending on Schottky Barriers and Diffusion Current in SiOC.

    Science.gov (United States)

    Oh, Teresa; Kim, Chy Hyung

    2016-02-01

    To obtain a diffusion current in SiOC, the aluminum doped zinc oxide films were deposited on SiOC/Si wafer by a RF magnetron sputtering. All the X-ray patterns of the SiOC films showed amorphous phases. The level of binding energy of Si atoms will lead to an additional potential modulation by long range Coulombic and covalent interactions with oxygen ions. The growth of the AZO film was affected by the characteristics of SiOC, resulting in similar trends in XPS spectra and a shift to higher AZO lattice d values than the original AZO d values in XRD analyses. The charges trapped by the defects at the interlayer between AZO and SiOC films induced the decreased mobility of carriers. In the absence of trap charges, AZO grown on SiOC film such as the sample prepared at O2 = 25 or 30 sccm, which has low charge carrier concentration and high mobility, showed high mobility in an ambipolar characteristic of oxide semiconductor due to the tunneling effect and diffusion current. The structural matching of an interface between AZO and amorphous SiOC enhanced the height of Schottky Barrier (SB), and then the mobility was increased by the tunneling effect from band to band through the high SB.

  12. A Dynamic Programming Approach for Pricing Weather Derivatives under Issuer Default Risk

    Directory of Open Access Journals (Sweden)

    Wolfgang Karl Härdle

    2017-10-01

    Full Text Available Weather derivatives are contingent claims with payoff based on a pre-specified weather index. Firms exposed to weather risk can transfer it to financial markets via weather derivatives. We develop a utility-based model for pricing baskets of weather derivatives under default risk on the issuer side in over-the-counter markets. In our model, agents maximise the expected utility of their terminal wealth, while they dynamically rebalance their weather portfolios over a finite investment horizon. Using dynamic programming approach, we obtain semi-closed forms for the equilibrium prices of weather derivatives and for the optimal strategies of the agents. We give an example on how to price rainfall derivatives on selected stations in China in the universe of a financial investor and a weather exposed crop insurer.

  13. 50 CFR 296.10 - Agency review.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Agency review. 296.10 Section 296.10..., DEPARTMENT OF COMMERCE CONTINENTAL SHELF FISHERMEN'S CONTINGENCY FUND § 296.10 Agency review. (a) Within 30..., NMFS, or his designee, for a review of the initial determination. (b) The petitioner may submit written...

  14. 77 FR 14272 - Review and Approval of Projects

    Science.gov (United States)

    2012-03-09

    ... SUSQUEHANNA RIVER BASIN COMMISSION 18 CFR Part 806 Review and Approval of Projects CFR Correction In Title 18 of the Code of Federal Regulations, Part 400 to End, revised as of April 1, 2011, on page 118, in Sec. 806.6, (b)(1)(i) and (ii) are removed. [FR Doc. 2012-5837 Filed 3-8-12; 8:45 am] BILLING...

  15. 76 FR 43724 - In the Matter of Certain Digital Imaging Devices and Related Software; Notice of Commission...

    Science.gov (United States)

    2011-07-21

    ... filed by Apple Inc. of Cupertino, California (``Apple''). 75 FR 28058 (May 19, 2010). The complaint... not exist with respect to the '964 patent as required by 19 U.S.C. 1337(a)(2). On June 1, 2011, Apple filed a petition for review of the ALJ's findings related to the '964 patent. Apple did not petition for...

  16. ZFPIP/Zfp462 is involved in P19 cell pluripotency and in their neuronal fate

    International Nuclear Information System (INIS)

    Masse, Julie; Piquet-Pellorce, Claire; Viet, Justine; Guerrier, Daniel; Pellerin, Isabelle; Deschamps, Stephane

    2011-01-01

    The nuclear zinc finger protein ZFPIP/Zfp462 is an important factor involved in cell division during the early embryonic development of vertebrates. In pluripotent P19 cells, ZFPIP/Zfp462 takes part in cell proliferation, likely via its role in maintaining chromatin structure. To further define the function of ZFPIP/Zfp462 in the mechanisms of pluripotency and cell differentiation, we constructed a stable P19 cell line in which ZFPIP/Zfp462 knockdown is inducible. We report that ZFPIP/Zfp462 was vital for mitosis and self-renewal in pluripotent P19 cells. Its depletion induced substantial decreases in the expression of the pluripotency genes Nanog, Oct4 and Sox2 and was associated with the transient expression of specific neuronal differentiation markers. We also demonstrated that ZFPIP/Zfp462 expression appears to be unnecessary after neuronal differentiation is induced in P19 cells. Taken together, our results strongly suggest that ZFPIP/Zfp462 is a key chromatin factor involved in maintaining P19 pluripotency and in the early mechanisms of neural differentiation but that it is dispensable in differentiated P19 cells.

  17. Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours

    Energy Technology Data Exchange (ETDEWEB)

    Xiong, Ji [Huashan Hospital of Fudan University, Department of Radiology, Shanghai (China); Huashan Hospital of Fudan University, Department of Neuropathology, Shanghai (China); Tan, Wenli [Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Department of Radiology, Shanghai (China); Wen, Jianbo; Pan, Jiawei; Zhang, Jun; Geng, Daoying [Huashan Hospital of Fudan University, Department of Radiology, Shanghai (China); Wang, Yin [Huashan Hospital of Fudan University, Department of Neuropathology, Shanghai (China)

    2016-06-15

    To explore the correlations of conventional MRI (cMRI) and diffusion tensor imaging (DTI) values with the 1p/19 codeletion and IDH mutations in oligodendroglial tumours (OTs). Eighty-four patients with OTs who underwent cMRI and DTI were retrospectively reviewed. The maximal fractional anisotropy and minimal apparent diffusion coefficient (ADC) were measured and compared using the Mann-Whitney U test. Receiver operating characteristic curves, logistic regression analysis and four-table statistics analysis were performed to predict genotypings. OTs with 1p/19q codeletion or IDH mutations were prone to locate in frontal (P = 0.106 and 0.005, respectively) and insular lobes and were associated with absent or blurry contrast enhancement (P = 0.040 and 0.013, respectively). DTI values showed significant differences between OTs with and without IDH mutations (P < 0.05) but not in OTs with and without 1p/19q loss. The Ki-67 index significantly correlated with IDH mutations (P = 0.002) but not with 1p/19q codeletion. A combination of DTI and cMRI for the identification of IDH mutations resulted in sensitivity, specificity, positive and negative predictive values of 92.2 %, 75.8 %, 93.8 % and 71.1 %, respectively. Combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in OTs. (orig.)

  18. Law Review of Islamic Capital Market Role to Support Sustainable Economic Development

    Directory of Open Access Journals (Sweden)

    Helza Nova Lita

    2014-03-01

    Full Text Available Objective - The objective of this paper is to assess on how the rule of Islamic capital markets to support   sustainable economic development and what kind of instruments can be developed.Method – The method used in this research is the study of normative juridical approach to legislation and the concept of Islamic economics through literature review.Result – Issuer's business activities related to support for environmentally friendly business activities are part of the implementation of sharia principles despite the provisions of the implementation of Islamic finance through a decision has not been stated . All types of instruments issued by issuers of sharia in Indonesia should be consistent with Islamic economic values, including the commitment to enforcement of environmentally friendly business activities.Conclusion – This finding suggests to strengthen the legal instruments in the issuer's issuance of Islamic instruments in the form of regulations issued by the Securities and Exchange Commission  and through the National Fatwa Council of Sharia.Keywords : Islamic Capital Markets, sustainable economic development, friendly environment

  19. Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

    International Nuclear Information System (INIS)

    Kelemen, Linda E; Köbel, Martin; Lurie, Galina; Thompson, Pamela J; Carney, Michael E; Moysich, Kirsten; Edwards, Robert; Bunker, Clare; Jensen, Allan; Høgdall, Estrid; Cramer, Daniel W; Bandera, Elisa V; Vitonis, Allison F; Olson, Sara H; King, Melony; Chandran, Urmila; Lissowska, Jolanta; Garcia-Closas, Montserrat; Yang, Hannah; Webb, Penelope M; Schildkraut, Joellen M; Goodman, Marc T; Terry, Kathryn L; Risch, Harvey A; Rossing, Mary Anne; Brinton, Louise A; Doherty, Jennifer A; Ness, Roberta B; Kjær, Susanne Krüger; Chang-Claude, Jenny

    2013-01-01

    Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations. We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol. Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations. We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community

  20. 76 FR 6110 - Conflict Minerals

    Science.gov (United States)

    2011-02-03

    ...-10] RIN 3235-AK84 Conflict Minerals AGENCY: Securities and Exchange Commission. ACTION: Proposed rule...'') and would require any such issuer for which conflict minerals are necessary to the functionality or... body of its annual report whether its conflict minerals originated in the Democratic Republic of the...

  1. CHANGES IN THE GLUTATHIONE SYSTEM IN P19 EMBRYONAL CARCINOMA CELLS UNDER HYPOXIC CONDITIONS

    Directory of Open Access Journals (Sweden)

    D. S. Orlov

    2015-01-01

    Full Text Available Introduction. According to modern perceptions, tumor growth, along with oxidative stress formation, is accompanied by hypoxia. Nowadays studying the regulation of cellular molecular system functioning by conformational changes in proteins appears to be a topical issue. Research goal was to evaluate the state of the glutathione system and the level of protein glutathionylation in P19 embryonal carcinoma (EC cells under hypoxic conditions.Material and methods. P19 EC cells (mouse embryonal carcinoma cultured under normoxic and hypox-ic conditions served the research material.The concentration of total, oxidized, reduced and protein-bound glutathione, the reduced to oxidized thiol ratio as well as glutathione peroxidase and glutathione reductase activity were determined by spectropho-tometry.Results. Glutathione imbalance was accompanied by a decrease in P19 EC cell redox status under hypox-ic conditions against the backdrop of a rise in protein-bound glutathione.Conclusions. As a result of the conducted study oxidative stress formation was identified when modeling hypoxia in P19 embryonal carcinoma cells. The rise in the concentration of protein-bound glutathione may indicate the role of protein glutathionylation in regulation of P19 cell metabolism and functions un-der hypoxia. 

  2. 19 CFR 10.99 - Importation of ethyl alcohol for nonbeverage purposes.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Importation of ethyl alcohol for nonbeverage purposes. 10.99 Section 10.99 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... Provisions Ethyl Alcohol § 10.99 Importation of ethyl alcohol for nonbeverage purposes. (a) If claim is made...

  3. 76 FR 65183 - National Oceanic and Atmospheric Administration

    Science.gov (United States)

    2011-10-20

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Climate Assessment... Oceanic and Atmospheric Administration (NOAA), Department of Commerce (DOC). ACTION: Notice of open..., National Oceanic and Atmospheric Administration. [FR Doc. 2011-27113 Filed 10-19-11; 8:45 am] BILLING CODE...

  4. Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis

    Czech Academy of Sciences Publication Activity Database

    Urbanová, Martina; Brus, Jiří; Šeděnková, Ivana; Policianová, Olivia; Kobera, Libor

    2013-01-01

    Roč. 100, 1 January (2013), s. 59-66 ISSN 1386-1425 R&D Projects: GA ČR GPP106/11/P426; GA MŠk 2B08021 Institutional research plan: CEZ:AV0Z40500505 Institutional support: RVO:61389013 Keywords : solid-state NMR * factor analysis * 19F MAS NMR Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 2.129, year: 2013

  5. 75 FR 13483 - Notice of Intent To Request an Information Collection

    Science.gov (United States)

    2010-03-22

    ... System (CES) of the LGUs and their Federal partner, the Extension Service, now the National Institute of... Jahn, Acting Under Secretary, Research, Education, and Economics. [FR Doc. 2010-6140 Filed 3-19-10; 8...

  6. 12 CFR 19.121 - Application for exemption.

    Science.gov (United States)

    2010-01-01

    ... for exemption. An issuer or an individual (officer, director or shareholder) may submit a written... the public interest or the protection of investors. The Securities and Corporate Practices Division...

  7. Inner-shell photoelectron angular distributions from fixed-in-space OCS molecules: comparison between experiment and theory

    Energy Technology Data Exchange (ETDEWEB)

    Golovin, A V [Photon Factory, Institute of Materials Structure Science, Tsukuba 305-0801 (Japan); Institute of Physics, St Petersburg State University, 198504 St Petersburg (Russian Federation); Adachi, J [Photon Factory, Institute of Materials Structure Science, Tsukuba 305-0801 (Japan); Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Motoki, S [Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, (Japan); Takahashi, M [Institute for Molecular Science, Okazaki 444-8585 (Japan); Yagishita, A [Photon Factory, Institute of Materials Structure Science, Tsukuba 305-0801 (Japan); Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan)

    2005-10-28

    Photoelectron angular distributions (PADs) for O 1s, C 1s and S 2p{sub 1/2}, 2p{sub 3/2} ionization of OCS molecules have been measured in shape resonance regions. These PAD results are compared with the results for O 1s and C 1s ionization of CO molecules, and multi-scattering X{alpha} (MSX{alpha}) calculations. The mechanism of the PAD formation both for parallel and perpendicular transitions differs very significantly in these molecules and a step from a two-centre potential (CO) to a three-centre potential (OCS) plays a principal role in electron scattering and the formation of the resulting PAD. For parallel transitions, it is found that for the S 2p and O 1s ionization the photoelectrons are emitted preferentially in a hemisphere directed to the ionized S and O atom, respectively. In OCS O 1s ionization, the S-C fragment plays the role of a strong 'scatterer' for photoelectrons, and in the shape resonance region most intensities of the PADs are concentrated on the region directed to the O atom. The MSX{alpha} calculations for perpendicular transitions reproduce the experimental data, but not so well as in the case of parallel transitions. The results of PAD, calculated with different l{sub max} on different atomic centres, reveal the important role of the d (l = 2) partial wave for the S atom in the partial wave decompositions of photoelectron wavefunctions.

  8. 77 FR 33476 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-06

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Hematology. Date: June 25-26, 2012. Time: 10:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant..., Drug Use, Food Insecurity. Date: June 26, 2012. Time: 1:00 p.m. to 5:00 p.m. Agenda: To review and...

  9. The O.C.: Our Guide to ALA in Anaheim

    Science.gov (United States)

    Hardstark, Georgia

    2008-01-01

    For those who grew up in Orange County (O.C.), Disneyland is the metaphoric morsel of food that gets stuck between the teeth of someone one does not like. While D-land is a must-see for millions of visitors each year, there is much more to Anaheim. Although O.C. is portrayed on numerous reality TV shows as a mecca for rich white people with…

  10. 77 FR 40081 - Gulf of Mexico, Outer Continental Shelf (OCS), Western Planning Area (WPA) and Central Planning...

    Science.gov (United States)

    2012-07-06

    ... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management Gulf of Mexico, Outer Continental Shelf (OCS), Western Planning Area (WPA) and Central Planning Area (CPA), Oil and Gas Lease Sales for 2012-2017 AGENCY: Bureau of Ocean Energy Management (BOEM), Interior. ACTION: Notice of availability...

  11. 78 FR 51752 - Sunshine Act Meetings; National Science Board

    Science.gov (United States)

    2013-08-21

    ... for the transaction of National Science Board business, as follows: DATE AND TIME: Monday, August 26, 2013 at 3:30 p.m. EST SUBJECT MATTER: Consideration of nominations for the NSB class of 2014- 2020... Bushmiller, NSB Senior Legal Counsel. [FR Doc. 2013-20485 Filed 8-19-13; 4:15 pm] BILLING CODE 7555-01-P ...

  12. IDH mutant and 1p/19q co-deleted oligodendrogliomas: tumor grade stratification using diffusion-, susceptibility-, and perfusion-weighted MRI

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Yu; Xing, Zhen; She, Dejun; Yang, Xiefeng; Zheng, Yingyan; Xiao, Zebin; Cao, Dairong [First Affiliated Hospital of Fujian Medical University, Department of Radiology, Fuzhou, Fujian (China); Wang, Xingfu [First Affiliated Hospital of Fujian Medical University, Department of Pathology, Fuzhou (China)

    2017-06-15

    Currently, isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion are proven diagnostic biomarkers for both grade II and III oligodendrogliomas (ODs). Non-invasive diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI), and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) are widely used to provide physiological information (cellularity, hemorrhage, calcifications, and angiogenesis) of neoplastic histology and tumor grade. However, it is unclear whether DWI, SWI, and DSC-PWI are able to stratify grades of IDH-mutant and 1p/19q co-deleted ODs. We retrospectively reviewed the conventional MRI (cMRI), DWI, SWI, and DSC-PWI obtained on 33 patients with IDH-mutated and 1p/19q co-deleted ODs. Features of cMRI, normalized ADC (nADC), intratumoral susceptibility signals (ITSSs), normalized maxim CBV (nCBV), and normalized maximum CBF (nCBF) were compared between low-grade ODs (LGOs) and high-grade ODs (HGOs). Receiver operating characteristic curve and logistic regression were applied to determine diagnostic performances. HGOs tended to present with prominent edema and enhancement. nADC, ITSSs, nCBV, and nCBF were significantly different between groups (all P < 0.05). The combination of SWI and DSC-PWI for grading resulted in sensitivity and specificity of 100.00 and 93.33%, respectively. IDH-mutant and 1p/19q co-deleted ODs can be stratified by grades using cMRI and advanced magnetic resonance imaging techniques including DWI, SWI, and DSC-PWI. Combined ITSSs with nCBV appear to be a promising option for grading molecularly defined ODs in clinical practice. (orig.)

  13. 76 FR 31518 - Disqualification of Felons and Other “Bad Actors” From Rule 506 Offerings

    Science.gov (United States)

    2011-06-01

    ... directors, officers and significant shareholders of the issuer) from participating in exempt securities... issuer and any predecessor of the issuer or affiliated issuer; Any director, officer, general partner or... has been or will be paid (directly or indirectly) remuneration for solicitation of purchasers in...

  14. 76 FR 76628 - Disclosure of Certain Credit Card Complaint Data

    Science.gov (United States)

    2011-12-08

    ... complaint. At the end of this process, the issuer reports to Consumer Response how it has addressed the... Proceedings (``OAEP'') discloses every month in its Air Travel Consumer Report.\\11\\ Unlike NHTSA, OAEP does... the OEAP began publishing the Air Travel Consumer Report.\\13\\ Outside reviewers have also publicized...

  15. 78 FR 59968 - Potential Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore Oregon...

    Science.gov (United States)

    2013-09-30

    ... technical and financial qualifications can be found at: http://www.boem.gov/Renewable-Energy-Program... submissions of indications of interest in obtaining a commercial lease for wind energy development on the OCS... area described in this notice, the potential environmental consequences of wind energy development in...

  16. Fossil and non-fossil sources of organic carbon (OC and elemental carbon (EC in Göteborg, Sweden

    Directory of Open Access Journals (Sweden)

    S. Szidat

    2009-03-01

    Full Text Available Particulate matter was collected at an urban site in Göteborg (Sweden in February/March 2005 and in June/July 2006. Additional samples were collected at a rural site for the winter period. Total carbon (TC concentrations were 2.1–3.6 μg m−3, 1.8–1.9 μg m−3, and 2.2–3.0 μg m−3 for urban/winter, rural/winter, and urban/summer conditions, respectively. Elemental carbon (EC, organic carbon (OC, water-insoluble OC (WINSOC, and water-soluble OC (WSOC were analyzed for 14C in order to distinguish fossil from non-fossil emissions. As wood burning is the single major source of non-fossil EC, its contribution can be quantified directly. For non-fossil OC, the wood-burning fraction was determined independently by levoglucosan and 14C analysis and combined using Latin-hypercube sampling (LHS. For the winter period, the relative contribution of EC from wood burning to the total EC was >3 times higher at the rural site compared to the urban site, whereas the absolute concentrations of EC from wood burning were elevated only moderately at the rural compared to the urban site. Thus, the urban site is substantially more influenced by fossil EC emissions. For summer, biogenic emissions dominated OC concentrations most likely due to secondary organic aerosol (SOA formation. During both seasons, a more pronounced fossil signal was observed for Göteborg than has previously been reported for Zurich, Switzerland. Analysis of air mass origin using back trajectories suggests that the fossil impact was larger when local sources dominated, whereas long-range transport caused an enhanced non-fossil signal. In comparison to other European locations, concentrations of levoglucosan and other monosaccharide anhydrides were low for the urban and the rural site in the area of Göteborg during winter.

  17. Superelasticity, corrosion resistance and biocompatibility of the Ti–19Zr–10Nb–1Fe alloy

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Pengfei [School of Materials Science and Engineering, Beihang University, Beijing 100191 (China); Key Laboratory of Aerospace Materials and Performance (Ministry of Education), Beihang University, Beijing 100191 (China); Li, Yan, E-mail: liyan@buaa.edu.cn [School of Materials Science and Engineering, Beihang University, Beijing 100191 (China); Key Laboratory of Aerospace Materials and Performance (Ministry of Education), Beihang University, Beijing 100191 (China); Li, Kangming [School of Materials Science and Engineering, Beihang University, Beijing 100191 (China); Key Laboratory of Aerospace Materials and Performance (Ministry of Education), Beihang University, Beijing 100191 (China); Zhang, Deyuan [Life Tech Scientific Corporation, Shenzhen 518057 (China); Zhou, Chungen [School of Materials Science and Engineering, Beihang University, Beijing 100191 (China)

    2015-05-01

    Microstructure, mechanical properties, superelasticity and biocompatibility of a Ti–19Zr–10Nb–1Fe alloy are investigated. X-ray diffraction spectroscopy and transmission electron microscopy observations show that the as-cast Ti–19Zr–10Nb–1Fe alloy is composed of α′ and β phases, but only the β phase exists in the as-rolled and as-quenched alloys. The tensile stress–strain tests indicate that the as-quenched alloy exhibits a good combination of mechanical properties with a large elongation of 25%, a low Young's modulus of 59 GPa and a high ultimate tensile stress of 723 MPa. Superelastic recovery behavior is found in the as-quenched alloy during tensile tests, and the corresponding maximum of superelastic strain is 4.7% at the pre-strain of 6%. A superelastic recovery of 4% with high stability is achieved after 10 cyclic loading–unloading training processes. Potentiodynamic polarization and ion release measurements indicate that the as-quenched alloy shows a lower corrosion rate in Hank's solution and a much less ion release rate in 0.9% NaCl solution than those of the NiTi alloys. Cell culture results indicate that the osteoblasts' adhesion and proliferation are similar on both the Ti–19Zr–10Nb–1Fe and NiTi alloys. A better hemocompatibility is confirmed for the as-quenched Ti–19Zr–10Nb–1Fe alloy, attributed to more stable platelet adhesion and small activation degree, and a much lower hemolysis rate compared with the NiTi alloy. - Highlights: • A stable superelastic strain of 4.0% is achieved for the Ti–19Zr–10Nb–1Fe alloy. • The ion release rates of Ti–19Zr–10Nb–1Fe are much lower than that of Ni in NiTi. • Ti–19Zr–10Nb–1Fe has a similar cytocompatibility compared with the NiTi alloy. • Ti–19Zr–10Nb–1Fe exhibits a better hemocompatibility than the NiTi alloy.

  18. 78 FR 28231 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-05-14

    ... Behavior Integrated Review Group, Social Psychology, Personality and Interpersonal Processes Study Section... Instrumentation: Cell Culture Bioreactor. Date: June 10, 2013. Time: 1:00 p.m. to 2:00 p.m. Agenda: To review and...

  19. Atmospheric Retrievals of HAT-P-16b and WASP-11b/HAT-P-10b

    Science.gov (United States)

    McIntyre, Kathleen; Harrington, Joseph; Challener, Ryan; Lenius, Maria; Hartman, Joel D.; Bakos, Gaspar A.; Blecic, Jasmina; Cubillos, Patricio E.; Cameron, Andrew

    2018-01-01

    We report Bayesian atmospheric retrievals performed on the exoplanets HAT-P-16b and WASP-11b/HAT-P-10b. HAT-P-16b is a hot (equilibrium temperature 1626 ± 40 K, assuming zero Bond albedo and efficient energy redistribution), 4.19 ± 0.09 Jupiter-mass exoplanet orbiting an F8 star every 2.775960 ± 0.000003 days (Buchhave et al 2010). WASP-11b/HAT-P-10b is a cooler (1020 ± 17 K), 0.487 ± 0.018 Jupiter-mass exoplanet orbiting a K3 star every 3.7224747 ± 0.0000065 days (Bakos et al. 2009, co-discovered by West et al. 2008). We observed secondary eclipses of both planets using the 3.6 μm and 4.5 μm channels of the Spitzer Space Telescope's Infrared Array Camera (program ID 60003). We applied our Photometry for Orbits, Eclipses, and Transits (POET) code to produce normalized eclipse light curves, and our Bayesian Atmospheric Radiative Transfer (BART) code to constrain the temperature-pressure profiles and atmospheric molecular abundances of the two planets. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

  20. [Familial febrile convulsions is supposed to link to human chromosome 19p13.3].

    Science.gov (United States)

    Qi, Y; Lü, J; Wu, X

    2001-01-10

    To localize the familial febrile convulsion (FC) genes on human chromosomes. For 63 FC pedigrees, tetranucleotide repeat markers D19S253 D19S395 and D19S591 on the short arm of chromosome 19, as well as dinucleotide repeat markers D8S84 and D8S85 on the long arm of chromosome 8 were genotyped. Transmission disequilibrium test (TDT) and Lod score calculation were carried out. The data were processed by PPAP software package. All the alleles in every locus of FC probands and normal controls were in Hardy-Weinburg balance. Transmission disequilibrium was found on D8S84, D19S395 and D19S591 in FC families. chi(2) values were 4.0, 5.124 and 7.364 separately. Each P value was < 0.05, and significantly meaningful. The two-point Lod scores between D8S84 and FC, D8S85 and FC, D19S253 and FC, D19S395 and FC, D19S591 and FC are 0.00002, 0.000017, 0.58, 1.53 and 1.42 respectively. The multi-point Lod score among markers on chromosome 8q and FC was 0.88, while Lod score among markers on chromosome 19p and FC reached 2.78. The results by both the non-parameter (TDT) and parameter (Lod score) methods were consistant on a whole. FC is linked with chromosome region 19p13.3, but not with chromosome 8q.

  1. 76 FR 23788 - Export Trade Certificate of Review

    Science.gov (United States)

    2011-04-28

    ... Competition and Economic Analysis (``OCEA'') of the International Trade Administration, Department of Commerce... and Economic Analysis, International Trade Administration, (202) 482-5131 (this is not a toll-free... Economic Analysis. [FR Doc. 2011-10249 Filed 4-27-11; 8:45 am] BILLING CODE 3510-DR-P ...

  2. Prevalencia de obesidad en una población de 10 a 19 años en la consulta pediátrica

    OpenAIRE

    Kovalskys, Irina; Bay, Luisa; Rausch Herscovici, Cecile; Berner, Enrique

    2005-01-01

    Introducción: La prevalencia mundial de obesidad es alarmante. La obesidad infantil está aumentando tanto en países desarrollados como en vías de desarrollo. Objetivo: Determinar la prevalencia de obesidad en niños y adolescentes de 10 a 19 años que asistieron a la consulta pediátrica pública y privada en Argentina. Población, material y métodos: Se utilizaron datos de un estudio poblacional mayor, diseñado para determinar prevalencia de trastornos alimentarios en adolescentes de 10 a 19 años...

  3. Retrospektiv undersökning av främre korsbandsskada hos fotbollsspelande damer på liganivå i Finland

    OpenAIRE

    Widjeskog, Maria

    2013-01-01

    Främre korsbandsskador är en av de vanligaste allvarliga skadorna bland kvinnliga fotbollsspelare och leder till minst 6 månaders uppehåll från tävlingssammanhang. En hel del studier har gjorts inom området. Den här studien försöker få fram riskfaktorer för skada, i hurudana situationer skadan sker, förebyggande möjligheter samt olikheter i rehabilitering. Studien är retrospektiv och 19 spelare deltog. Deltagarna är damfotbollsspelare som spelat ligafotboll i Finland något år mellan åren ...

  4. Oil-Spill Analysis: Gulf of Mexico Outer Continental Shelf (OCS) Lease Sales, Eastern Planning Area, 2003-2007 and Gulfwide OCS Program, 2003-2042

    Science.gov (United States)

    2002-09-01

    The Federal Government plans to offer U.S. Outer Continental Shelf (OCS) lands in the Eastern Planning Area of the Gulf of Mexico (GOM) for oil and gas leasing. This report summarizes results of that analysis, the objective of which was to estimate the risk of oil-spill contact to sensitive offshore and onshore environmental resources and socioeconomic features from oil spills accidentally occurring from the OCS activities.

  5. Validity of the classical monte carlo method to model the magnetic properties of a large transition-metal cluster: Mn19.

    Science.gov (United States)

    Lima, Nicola; Caneschi, Andrea; Gatteschi, Dante; Kritikos, Mikael; Westin, L Gunnar

    2006-03-20

    The susceptibility of the large transition-metal cluster [Mn19O12(MOE)14(MOEH)10].MOEH (MOE = OC2H2O-CH3) has been fitted through classical Monte Carlo simulation, and an estimation of the exchange coupling constants has been done. With these results, it has been possible to perform a full-matrix diagonalization of the cluster core, which was used to provide information on the nature of the low-lying levels.

  6. The Hydraulic Project Włocławek: Design, Studies, Construction and Operation

    Directory of Open Access Journals (Sweden)

    Wojciech Majewski

    2015-03-01

    Full Text Available The Hydraulic Project Włocławek was commissioned in 1970 as the first barrage of the Lower Vistula Cascade (LVC. The purpose of the LVC was to create an important source of hydro-energy and inland navigation route connecting central Poland with the port city of Gdańsk. Along the Lower Vistula (LV important cities and industrial centres are located. The Włocławek project still remains the only barrage on the LV thus creating a number of problems. The paper presents the basic hydrological and hydraulic data for the Vistula river, and describes the Włocławek project, hydraulic model investigations conducted in the design phase, the construction of the project and the main problems, attendant on its use, including the winter flood of 1982 in the upper part of the Włocławek reservoir. The paper ends with conclusions on project construction and exploitation. The next barrage downstream from Włocławek is proposed.

  7. Loss of chromosome 1p/19q in oligodendroglial tumors: refinement of chromosomal critical regions and evaluation of internexin immunostaining as a surrogate marker.

    LENUS (Irish Health Repository)

    Buckley, Patrick G

    2011-03-01

    Loss of chromosome 1p\\/19q in oligodendrogliomas represents a powerful predictor of good prognosis. Expression of internexin (INA), a neuronal specific intermediate filament protein, has recently been proposed as a surrogate marker for 1p\\/19q deletion based on the high degree of correlation between both parameters in oligodendrogliomas. The aim of this study was to assess further the diagnostic utility of INA expression in a set of genetically well-characterized oligodendrogliomas. On the basis of a conservative approach for copy number determination, using both comparative genomic hybridization and fluorescent in situ hybridization, INA expression as a surrogate marker for 1p\\/19q loss had both reduced specificity (80%) and sensitivity (79%) compared with respective values of 86% and 96% reported in the previous report. The histologic interpretation and diagnostic value of INA expression in oligodendrogliomas should therefore be assessed with greater caution when compared with 1p\\/19q DNA copy number analysis. In addition, DNA copy number aberrations of chromosomes 10, 16, and 17 were detected exclusively in 1p\\/19q codeleted samples, suggesting that other regions of the genome may contribute to the 1p\\/19q-deleted tumor phenotype inthese samples.

  8. Perinatal characteristics among early (10–14 years old and late (15–19 years old pregnant adolescents

    Directory of Open Access Journals (Sweden)

    Alves João

    2012-09-01

    Full Text Available Abstract Background Pregnancy in adolescents is a worldwide health problem and has been mostly common in poor populations. It is not clear if socioeconomic or biological factors are the main determinants of perinatal adverse outcomes in pregnant adolescents. Adolescents under 15 years old may present a high growth rate which may contribute to impair fetal growth. Our aim is to compare perinatal characteristics among early (aged 10 to 14 years and late (aged 15 to 19 years pregnant adolescents. Methods A cross-sectional study was performed using data from Pernambuco State 2009, obtained from DATASUS/SISNAC, a Brazilian Government, open-access public health database. Maternal and neonatal outcomes were compared between early (aged 10–14 years and late (aged 15–19 years pregnant adolescents. Family income was compared between early and late pregnant adolescents using a sample of 412 subjects evaluated at Instituto de Medicina Integral Prof. Fernando Figueira (IMIP during 2011. Statistical comparisons were made using the chi-square test was used with a significant level of 0.05; bivariate and multivariate analysis were performed. This project was approved by the Institutional Ethics Review Board. Results Data from 31,209 pregnant adolescents were analyzed. 29,733 (95.2% were aged 15 to 19 years and 1,476 (4.7% were aged 10 to 14 years. There were significant differences with respect to marital status, education level and number of prenatal visits of mothers aged 10 to 14 years compared to 15 to 19 years. Of importance, early adolescents had a greater rate of neonates born premature and with low birth weight. Prematurity and low birth weight remained statistically significant after multivariate analysis. Conclusions Early aged adolescents may have an increased risk of prematurity and low birth weight. These findings highlight the potential role of biological factors in newborn outcomes in pregnant adolescents.

  9. Age-related differences in 1p and 19q deletions in oligodendrogliomas

    Directory of Open Access Journals (Sweden)

    Del Bigio Marc R

    2003-12-01

    Full Text Available Abstract Background Recent reports indicate that anaplastic oligodendrogliomas frequently show allelic losses on chromosome arms 1p and 19q, and that these deletions are associated with better chemotherapeutic response and overall patient survival. Because of the diversified genetic makeup of the population and the centralized provincial referral system for brain tumor patients in Manitoba, the epidemiological features of such tumors sometimes differ from the published data acquired from non-community based settings. In this study, we assessed the prevalence of allelic deletions for chromosome arms 1p and 19q in anaplastic and in low-grade oligodendrogliomas in the Manitoba population. Methods Loss of heterozygosity (LOH analysis of brain tumors was carried out using 4 microsatellite markers (D1S508, D1S2734, D19S219 and D19S412 and a PCR based assay. The tumors were consecutively acquired during the period September 1999–March 2001 and a total of 63 tumors were assessed. Results We found that allelic loss of chromosome 1p and 19q was higher in oligodendrogliomas than in other diffuse gliomas and that for anaplastic oligodendrogliomas, younger patients exhibited significantly more deletions than older patients (>60 years of age. Conclusions These studies suggest that age may be a factor in the genetic alterations of oligodendrogliomas. In addition, these studies demonstrate that this assay can easily be carried out in a cost-effective manner in a small tertiary center.

  10. 75 FR 60844 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Order Granting...

    Science.gov (United States)

    2010-10-01

    ...-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Order Granting Accelerated... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on September 14, 2010, The NASDAQ Stock Market... voting on the election of a member of the board of directors of an issuer (except for a vote with respect...

  11. 78 FR 760 - Potential Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore New...

    Science.gov (United States)

    2013-01-04

    ... technical and financial qualifications can be found at: http://www.boem.gov/Renewable-Energy-Program... lease for wind energy development on the OCS offshore New York for the area identified in this notice... project to supply the Long Island and New York City region with renewable energy, consistent with New York...

  12. 77 FR 66909 - Notification of Contact Information Change for the Benghazi Accountability Review Board

    Science.gov (United States)

    2012-11-07

    ... DEPARTMENT OF STATE [Public Notice 8080] Notification of Contact Information Change for the Benghazi Accountability Review Board SUMMARY: On October 1, 2012, the Department of State announced the formation of the Benghazi Accountability Review Board (ARB) in the Federal Register (FR Doc. 2012-24504...

  13. Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins

    International Nuclear Information System (INIS)

    Kim, Se-Jin; Park, Channy; Lee, Joon No; Lim, Hyewon; Hong, Gi-yeon; Moon, Sung K.; Lim, David J.; Choe, Seong-Kyu; Park, Raekil

    2015-01-01

    Cisplatin has many adverse effects, which are a major limitation to its use, including ototoxicity, neurotoxicity, and nephrotoxicity. This study aims to elucidate the protective mechanisms of erdosteine against cisplatin in HEI-OC1 cells. Pretreatment with erdosteine protects HEI-OC1 cells from cisplatin-medicated apoptosis, which is characterized by increase in nuclear fragmentation, DNA laddering, sub-G 0 /G 1 phase, H2AX phosphorylation, PARP cleavage, and caspase-3 activity. Erdosteine significantly suppressed the production of reactive nitrogen/oxygen species and pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in cisplatin-treated cells. Studies using pharmacologic inhibitors demonstrated that phosphatidylinositol-3-kinases (PI3K) and protein kinase B (Akt) have protective roles in the action of erdosteine against cisplatin in HEI-OC1 cells. In addition, pretreatment with erdosteine clearly suppressed the phosphorylation of p53 (Ser15) and expression of p53-upregulated modulator of apoptosis. Erdosteine markedly induces expression of NF-E2-related factor 2 (Nrf2), which may contribute to the increase in expression of glutathione redox genes γ-L-glutamate-L-cysteine-ligase catalytic and γ-L-glutamate-L-cysteine-ligase modifier subunits, as well as in the antioxidant genes HO-1 and SOD2 in cisplatin-treated HEI-OC1 cells. Furthermore, the increase in expression of phosphorylated p53 induced by cisplatin is markedly attenuated by pretreatment with erdosteine in the mitochondrial fraction. This increased expression may inhibit the cytosolic expression of the apoptosis-inducing factor, cytochrome c, and Bax/Bcl-xL ratio. Thus, our results suggest that treatment with erdosteine is significantly attenuated cisplatin-induced damage through the activation of Nrf2-dependent antioxidant genes, inhibition of pro-inflammatory cytokines, activation of the PI3K/Akt signaling, and mitochondrial-related inhibition of pro

  14. 75 FR 70268 - Submission for OMB Review; Comment Request; NIH NCI Central Institutional Review Board (CIRB...

    Science.gov (United States)

    2010-11-17

    ... each time the person contacts the helpdesk. Frequency of Response: Once, except for the SAE Reviewer... Statistical Reviewer Form 20 1 2 hours 40 (Attachment 6J). Board Members CIRB SAE Reviewer Worksheet 10 15 30... 4140-01-P ...

  15. Rague-Like FeP Nanocrystal Assembly on Carbon Cloth: An Exceptionally Efficient and Stable Cathode for Hydrogen Evolution

    KAUST Repository

    Yang, Xiulin

    2015-05-25

    There is a strong demand to replace expensive Pt catalysts with cheap metal sulfides or phosphides for hydrogen generation in water electrolysis. The earth-abundant Fe can be electroplated on carbon cloth (CC) to form high surface area rague-like FeOOH assembly. Subsequent gas phase phosphidation converts the FeOOH to FeP or FeP2 and the morphology of the crystal assembly is controlled by the phosphidation temperature. The FeP prepared at 250 oC presents lower crystallinity and those prepared at higher temperatures 400 oC and 500 oC possess higher crystallinity but lower surface area. The phosphidation at 300 oC produces nanocrystalline FeP and preserves the high-surface area morphology; thus it exhibits the highest HER efficiency in 0.5 M H2SO4; i.e. the required overpotential to reach 10 and 20 mA/cm2 is 34 and 43 mV respectively. These values are lowest among the reported non-precious metal phosphides on CC. The Tafel slope for the FeP prepared at 300 oC is around 29.2 mV/dec comparable to that of Pt/CC, indicating that the hydrogen evolution for our best FeP is limited by Tafel reaction (same as Pt). Importantly, the FeP/CC catalyst exhibits much better stability in a wide range working current density (up to 1 V/cm2), suggesting that it is a promising replacement of Pt for HER.

  16. Rague-Like FeP Nanocrystal Assembly on Carbon Cloth: An Exceptionally Efficient and Stable Cathode for Hydrogen Evolution

    KAUST Repository

    Yang, Xiulin; Lu, Ang-Yu; Zhu, Yihan; Min, Shixiong; Hedhili, Mohamed N.; Han, Yu; Huang, Kuo-Wei; Li, Lain-Jong

    2015-01-01

    There is a strong demand to replace expensive Pt catalysts with cheap metal sulfides or phosphides for hydrogen generation in water electrolysis. The earth-abundant Fe can be electroplated on carbon cloth (CC) to form high surface area rague-like FeOOH assembly. Subsequent gas phase phosphidation converts the FeOOH to FeP or FeP2 and the morphology of the crystal assembly is controlled by the phosphidation temperature. The FeP prepared at 250 oC presents lower crystallinity and those prepared at higher temperatures 400 oC and 500 oC possess higher crystallinity but lower surface area. The phosphidation at 300 oC produces nanocrystalline FeP and preserves the high-surface area morphology; thus it exhibits the highest HER efficiency in 0.5 M H2SO4; i.e. the required overpotential to reach 10 and 20 mA/cm2 is 34 and 43 mV respectively. These values are lowest among the reported non-precious metal phosphides on CC. The Tafel slope for the FeP prepared at 300 oC is around 29.2 mV/dec comparable to that of Pt/CC, indicating that the hydrogen evolution for our best FeP is limited by Tafel reaction (same as Pt). Importantly, the FeP/CC catalyst exhibits much better stability in a wide range working current density (up to 1 V/cm2), suggesting that it is a promising replacement of Pt for HER.

  17. 29 CFR 19.1 - Definitions.

    Science.gov (United States)

    2010-07-01

    ...: (a) Financial institution means any office of a bank, savings bank, card issuer as defined in section 103 of the Consumer Credit Protection Act (15 U.S.C. 1602(n)), industrial loan company, trust company, savings and loan, building and loan, or homestead association (including cooperative banks), credit union...

  18. Exercise mitigates cumulative associations between stress and BMI in girls age 1019

    Science.gov (United States)

    Prather, Aric A.; Epel, Elissa S.; Loharuka, Sheila; Adler, Nancy E.; Laraia, Barbara

    2015-01-01

    Objective Long-term psychological stress is associated with BMI increases in children as they transition to adulthood, while long-term maintenance of physical activity can slow excess weight gain. We hypothesized that in addition to these main effects, long-term physical activity mitigates the relationship between long-term stress and BMI increase. Methods The NHLBI Growth and Health Study enrolled 2,379 10-year-old Black and White girls, following them annually for 10 measurement points. Growth curve modeling captured the dynamics of BMI, measured yearly, and stress and physical activity, measured every other year. Results At average levels of activity and stress, with all covariates remaining fixed, average BMI at baseline was 19.74 (SE = 0.38) and increased 0.64 BMI (SE= 0.01, p psychological stress. PMID:26301595

  19. Study of the (p,pd), (p,pt) and (p,p3He) reactions on 12C and 16O at 75MeV

    International Nuclear Information System (INIS)

    Grossiord, J.Y.; Bedjidian, M.; Guichard, A.; Gusakow, M.; Pizzi, J.R.

    1975-01-01

    The (p,pd), (p,pt) and (p,p 3 He) quasi-free scattering reactions have been studied on 12 C and 16 O targets at 75MeV. The low lying excitation levels of the residual nuclei have been observed. The appearance of T=1 states in 10 B and 14 N and of positive parity states in 13 N and 13 C can only be explained by reaction mechanisms more complex than a simple quasi-free scattering. A comparison of relative values of experimental spectroscopic factors with theoretical calculations has been made in the case of the most populated states [fr

  20. Synthesis and preclinical evaluation of the choline transport tracer deshydroxy-[18F]fluorocholine ([18F]dOC)

    International Nuclear Information System (INIS)

    Henriksen, G.; Herz, M.; Hauser, A.; Schwaiger, M.; Wester, H.-J.

    2004-01-01

    11 C-labeled choline ([ 11 C]CHO) and 18 F-fluorinated choline analogues have been demonstrated to be valuable tracers for in vivo imaging of neoplasms by means of positron emission tomography (PET). The objective of the present study was to evaluate whether deshydroxy-[ 18 F]fluorocholine, ([ 18 F]dOC), a non-metabolizable [ 18 F]fluorinated choline analogue, can serve as a surrogate for cholines that are able to be phosphorylated and thus allow PET-imaging solely by addressing the choline transport system. The specificity of uptake of [ 18 F]dOC was compared with that of [ 11 C]choline ([ 11 C]CHO) in cultured rat pancreatic carcinoma and PC-3 human prostate cancer cells in vitro. In addition, biodistribution of [ 18 F]dOC and [ 11 C]CHO was compared in AR42J- and PC-3 tumor bearing mice. The in vitro studies revealed that membrane transport of both compounds can be inhibited in a concentration dependent manner by similar concentrations of cold choline (IC 50 [ 18 F]dOC= 11 μM; IC 50 [ 11 C]CHO=13 μM. In vitro studies with PC-3 and AR42J cells revealed that the internalized fraction of [ 18 F]dOC after 5 min incubation time is comparable to that of [ 11 C]CHO, whereas the uptake of [ 11 C]CHO was superior after 20 min incubation time. As for [ 11 C]CHO, kidney and liver were also the primary sites of uptake for [ 18 F]dOC in vivo. Biodistribution data after simultaneous injection of both tracers into AR42J tumor bearing mice revealed slightly higher tumor uptake for [ 18 F]dOC at 10 min post-injection, whereas [ 11 C]CHO uptake was higher at later time points. In conclusion, [ 18 F]dOC is taken up into AR42J rat pancreatic carcinoma and PC-3 human prostate cancer cells by a choline specific transport system. Similar transport rates of [ 18 F]dOC and [ 11 C]CHO result in comparable cellular uptake levels at early time points. In contrast to [ 18 F]dOC, which is transported but not intracellularily trapped, the choline kinase substrate [ 11 C]CHO is transported

  1. 75 FR 21653 - Commercial Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore Delaware-Request...

    Science.gov (United States)

    2010-04-26

    ... Leasing for Wind Power on the Outer Continental Shelf (OCS) Offshore Delaware--Request for Interest (RFI... proposal. In June 2008, Bluewater Wind Delaware LLC announced that it signed a 25-year power purchase agreement with Delmarva Power to sell up to 200 megawatts (MW) of power to the utility from an offshore wind...

  2. 19 CFR 10.589 - Certification for goods exported to a Party.

    Science.gov (United States)

    2010-04-01

    ... such other medium or format approved by the Party's customs authority for that purpose) to CBP upon... 19 Customs Duties 1 2010-04-01 2010-04-01 false Certification for goods exported to a Party. 10.589 Section 10.589 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY...

  3. 76 FR 50245 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas...

    Science.gov (United States)

    2011-08-12

    ... (BOEMRE), Interior. ACTION: Notice of Availability (NOA) of a Final Supplemental Environmental Impact... sale's incremental contribution to the cumulative impacts on environmental and socioeconomic resources... Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA), Oil and Gas Lease Sale for the...

  4. 77 FR 70875 - Department of State Performance Review Board Members

    Science.gov (United States)

    2012-11-27

    ..., Department of State; Kevin P. O'Keefe, Director, Office of Plans, Policy, and Analysis, Bureau of Political...-Greenfield, Director General of the Foreign Service and Director of Human Resources, Department of State. [FR...

  5. Cardiovascular, respiratory and metabolic responses to temperature and hypoxia of the winter frog Rana catesbeiana

    Directory of Open Access Journals (Sweden)

    Rocha P.L.

    1997-01-01

    Full Text Available The objective of the present study was to determine the effects of hypoxia and temperature on the cardiovascular and respiratory systems and plasma glucose levels of the winter bullfrog Rana catesbeiana. Body temperature was maintained at 10, 15, 25 and 35oC for measurements of breathing frequency, heart rate, arterial blood pressure, metabolic rate, plasma glucose levels, blood gases and acid-base status. Reducing body temperature from 35 to 10oC decreased (P<0.001 heart rate (bpm from 64.0 ± 3.1 (N = 5 to 12.5 ± 2.5 (N = 6 and blood pressure (mmHg (P<0.05 from 41.9 ± 2.1 (N = 5 to 33.1 ± 2.1 (N = 6, whereas no significant changes were observed under hypoxia. Hypoxia-induced changes in breathing frequency and acid-base status were proportional to body temperature, being pronounced at 25oC, less so at 15oC, and absent at 10oC. Hypoxia at 35oC was lethal. Under normoxia, plasma glucose concentration (mg/dl decreased (P<0.01 from 53.0 ± 3.4 (N = 6 to 35.9 ± 1.7 (N = 6 at body temperatures of 35 and 10oC, respectively. Hypoxia had no significant effect on plasma glucose concentration at 10 and 15oC, but at 25oC there was a significant increase under conditions of 3% inspired O2. The arterial PO2 and pH values were similar to those reported in previous studies on non-estivating Rana catesbeiana, but PaCO2 (37.5 ± 1.9 mmHg, N = 5 was 3-fold higher, indicating increased plasma bicarbonate levels. The estivating bullfrog may be exposed not only to low temperatures but also to hypoxia. These animals show temperature-dependent responses that may be beneficial since during low body temperatures the sensitivity of most physiological systems to hypoxia is reduced

  6. 76 FR 29156 - Outer Continental Shelf Air Regulations Consistency Update for California

    Science.gov (United States)

    2011-05-20

    ... response, using the definition of burden provided in 44 U.S.C. 3502(2). The Congressional Review Act, 5 U.S... procedures, Air pollution control, Hydrocarbons, Incorporation by reference, Intergovernmental relations... OCS Sources: Rule 102 Definitions (Adopted 09/20/10). Rule 103 Severability (Adopted 10/23/78). Rule...

  7. 76 FR 40950 - Public Company Accounting Oversight Board; Notice of Filing of Proposed Board Funding Final Rules...

    Science.gov (United States)

    2011-07-12

    ... available, the issuer's net asset value. (i)(v) Issuer Accounting Support Fee The term ``issuer accounting... Accounting Oversight Board; Notice of Filing of Proposed Board Funding Final Rules for Allocation of the Board's Accounting Support Fee Among Issuers, Brokers, and Dealers, and Other Amendments to the Board's...

  8. 78 FR 12071 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-21

    ...: Immunology. Date: March 13, 2013. Time: 8:00 a.m. to 10:00 p.m. Agenda: To review and evaluate [email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel; Special Topics: Topics in Bacterial Pathogenesis. Date: March 14-15, 2013. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review...

  9. 78 FR 21969 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA) Lease Sale 233...

    Science.gov (United States)

    2013-04-12

    .... ACTION: Notice of Availability (NOA) of the Final Supplemental Environmental Impact Statement (EIS... Environmental Impact Statement (OCS EIS/EA BOEM 2012-019) (2012-2017 Multisale EIS), completed in July 2012, in... to the cumulative impacts on environmental and socioeconomic resources. The oil and gas resource...

  10. 78 FR 42544 - Outer Continental Shelf (OCS), Gulf of Mexico (GOM), Oil and Gas Lease Sale, Western Planning...

    Science.gov (United States)

    2013-07-16

    ... Prepare a Supplemental Environmental Impact Statement (EIS) SUMMARY: Consistent with the regulations... 248; Central Planning Area (CPA) Lease Sales 227, 231, 235, 241, and 247, Final Environmental Impact... Supplemental Environmental Impact Statement (OCS EIS/EA BOEM 2013-0118) (WPA 233/CPA 231 Supplemental EIS). The...

  11. 78 FR 36201 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-06-17

    ..., Computational, and Molecular Biology. Date: July 11, 2013. Time: 10:00 a.m. to 6:00 p.m. Agenda: To review and... Panel; Member Conflict: Cancer Biology. Date: July 17, 2013. Time: 2:00 p.m. to 4:00 p.m. Agenda: To...: Center for Scientific Review Special Emphasis Panel; Member Conflict: Molecular Neurogenetics and...

  12. Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

    Directory of Open Access Journals (Sweden)

    Kelemen Linda E

    2013-01-01

    Full Text Available Abstract Background Studies evaluating the association between alcohol intake and ovarian carcinoma (OC are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations. Methods We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR and 95% confidence intervals (CI according to frequencies of average daily intakes of beer, wine, liquor and total alcohol. Results Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08. This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02, although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09. Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations. Conclusions We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.

  13. 19 CFR 191.1 - Authority of the Commissioner of Customs.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Authority of the Commissioner of Customs. 191.1 Section 191.1 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Customs. Pursuant to Treasury Department Order No. 165, Revised (T.D. 53654, 19 FR 7241), as amended, the...

  14. Investigation of the open-circuit voltage in wide-bandgap InGaP-host InP quantum dot intermediate-band solar cells

    Science.gov (United States)

    Aihara, Taketo; Tayagaki, Takeshi; Nagato, Yuki; Okano, Yoshinobu; Sugaya, Takeyoshi

    2018-04-01

    To analyze the open-circuit voltage (V oc) in intermediate-band solar cells, we investigated the current-voltage characteristics in wide-bandgap InGaP-based InP quantum dot (QD) solar cells. From the temperature dependence of the current-voltage curves, we show that the V oc in InP QD solar cells increases with decreasing temperature. We use a simple diode model to extract V oc at the zero-temperature limit, V 0, and the temperature coefficient C of the solar cells. Our results show that, while the C of InP QD solar cells is slightly larger than that of the reference InGaP solar cells, V 0 significantly decreases and coincides with the bandgap energy of the InP QDs rather than that of the InGaP host. This V 0 indicates that the V oc reduction in the InP QD solar cells is primarily caused by the breaking of the Fermi energy separation between the QDs and the host semiconductor in intermediate-band solar cells, rather than by enhanced carrier recombination.

  15. 12 CFR 19.135 - Applications for stay or review of disciplinary actions imposed by registered clearing agencies.

    Science.gov (United States)

    2010-01-01

    ... Involving the Federal Securities Laws § 19.135 Applications for stay or review of disciplinary actions... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Applications for stay or review of disciplinary actions imposed by registered clearing agencies. 19.135 Section 19.135 Banks and Banking COMPTROLLER OF...

  16. 19 CFR 10.57 - Certified seed potatoes, and seed corn or maize.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Certified seed potatoes, and seed corn or maize... Provisions Potatoes, Corn, Or Maize § 10.57 Certified seed potatoes, and seed corn or maize. Claim for classification as seed potatoes under subheading 0701.10.00, as seed corn (maize) under subheading 1005.10...

  17. 77 FR 22332 - Center for Scientific Review; Notice of Meeting

    Science.gov (United States)

    2012-04-13

    ... meeting will be open to the public with attendance limited to space available. Individuals who plan to... Advisory Committee Policy. [FR Doc. 2012-8919 Filed 4-12-12; 8:45 am] BILLING CODE 4140-01-P ...

  18. 77 FR 59202 - Center for Scientific Review; Notice of Meeting

    Science.gov (United States)

    2012-09-26

    ... meeting will be open to the public, with attendance limited to space available. Individuals who plan to... Advisory Committee Policy. [FR Doc. 2012-23624 Filed 9-25-12; 8:45 am] BILLING CODE 4140-01-P ...

  19. 77 FR 30335 - Proposed Revision 3 to Standard Review Plan, Section 19.1 on Determining the Technical Adequacy...

    Science.gov (United States)

    2012-05-22

    ...). The Office of New Reactors and Office of Nuclear Reactor Regulation are revising SRP Section 19.1... of the Code of Federal Regulations (10 CFR), 50.71(h)(1), (h)(2), and (h)(3) for new reactors, (2... searching on http://www.regulations.gov under Docket ID NRC-2012-0113. You may submit comments by the...

  20. 76 FR 19516 - Public Meeting/Notice of Availability, Review, and Comment on Preliminary Alternatives for the...

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    2011-04-07

    ..., Review, and Comment on Preliminary Alternatives for the Development of an Air Tour Management Plan for... Park Service, Hawaii Volcanoes National Park and the FAA's Air Tour Management Program. This document... Center, 1 Crater Rim Drive. P[amacr]hoa, Hawaii, Tuesday, April 19, 2011, 5-7 p.m., P[amacr]hoa Community...

  1. Low-resistance and highly transparent Ag/IZO ohmic contact to p-type GaN

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Han-Ki, E-mail: imdlhkkim@khu.ac.k [Department of Display Materials Engineering, Kyung Hee University, 1 Seochoen-dong, Yongin-si, Gyeonggi-do 446-701 (Korea, Republic of); Yi, Min-Su [Department of Materials Science and Engineering, Kyungpook National University, Sangju, Gyeongbuk, 742-711 (Korea, Republic of); Lee, Sung-Nam [Department of Engineering in Energy and Applied Chemistry, Silla University, Busan, 617-736 (Korea, Republic of)

    2009-05-29

    The electrical, structural, and optical characteristics of Ag/ZnO-doped In{sub 2}O{sub 3} (IZO) ohmic contacts to p-type GaN:Mg (2.5 x 10{sup 17} cm{sup -3}) were investigated. The Ag and IZO (10 nm/50 nm) layers were prepared by thermal evaporation and linear facing target sputtering, respectively. Although the as-deposited and 400 {sup o}C annealed samples showed rectifying behavior, the 500 and 600 {sup o}C annealed samples showed linear I-V characteristics indicative of the formation of an ohmic contact. The annealing of the contact at 600 {sup o}C for 3 min in a vacuum ({approx} 10{sup -3} Torr) resulted in the lowest specific contact resistivity of 1.8 x 10{sup -4} {Omega}.cm{sup 2} and high transparency of 78% at a wavelength of 470 nm. Using Auger electron spectroscopy, depth profiling and synchrotron X-ray scattering analysis, we suggested a possible mechanism to explain the annealing dependence of the electrical properties of the Ag/IZO contacts.

  2. Particle detectors based on InP Schottky diodes

    Czech Academy of Sciences Publication Activity Database

    Yatskiv, Roman; Grym, Jan

    2012-01-01

    Roč. 10, č. 7 (2012), C100051-C100055 ISSN 1748-0221 R&D Projects: GA MŠk(CZ) OC10021; GA MŠk LD12014 Institutional support: RVO:67985882 Keywords : Particle detector * High purity InP layer * Schottky diode Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 1.869, year: 2011

  3. The Chemokine CXCL-10 Is a Marker of Infection Stage in Individuals With DNAemia Due to Parvovirus B19.

    Science.gov (United States)

    Weseslindtner, Lukas; Aberle, Judith H; Hedman, Lea; Hedman, Klaus

    2017-01-15

    Accurate diagnosis of parvovirus B19 (B19V) infection requires the differentiation between acute and past infection, which is especially important when DNAemia due to B19V (hereafter, "B19V DNAemia") is detected in pregnancy. Here, we explored whether the level of the chemokine CXCL-10, in combination with findings of molecular and serological assays, can discriminate between acute and past B19V infection. B19V DNA-positive serum samples from 222 immunocompetent individuals were analyzed for (1) viral DNA loads, (2) anti-B19V immunoglobulin M (IgM) and immunoglobulin G (IgG), (3) anti-VP1 IgG avidity, (4) anti-VP-2 epitope type specificity (ETS), and (5) CXCL-10 serum levels. Anti-B19V IgM and IgG, avidity, and ETS assays were used to categorize individuals with B19V DNAemia as having acute or past B19V infection. Acute B19V infection caused a significant increase in the serum concentration of CXCL-10, compared with the concentration at baseline, before infection. Higher CXCL-10 serum levels were furthermore detected in acute B19V infection as compared to past infection. As a marker, CXCL-10 serum levels could discriminate between acute and past B19V infection, with an excellent discriminatory capacity when CXCL-10 and B19V DNA levels were used as combined parameters. Acute B19V infection is associated with increased CXCL-10 production, and measurement of CXCL-10 serum levels thus allows for the staging of B19V infection in individuals with B19V DNAemia. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  4. 76 FR 35755 - Listing Endangered and Threatened Species: Threatened Status for the Oregon Coast Coho Salmon...

    Science.gov (United States)

    2011-06-20

    ... Oregon Coast Coho Salmon Evolutionarily Significant Unit AGENCY: National Marine Fisheries Service (NMFS... the Oregon Coast (OC) Evolutionarily Significant Unit (ESU) of coho salmon (Oncorhynchus kisutch... coho salmon ESU as threatened under the ESA in 1995 (60 FR 38011; July 25, 1995). Since then, we have...

  5. Relatives with opposite chromosome constitutions, rec(10)dup(10p)inv(10)(p15.1q26.12) and rec(10)dup(10q)inv(10)(p15.1q26.12), due to a familial pericentric inversion.

    Science.gov (United States)

    Ciuladaite, Zivile; Preiksaitiene, Egle; Utkus, Algirdas; Kučinskas, Vaidutis

    2014-01-01

    Large pericentric inversions in chromosome 10 are rare chromosomal aberrations with only few cases of familial inheritance. Such chromosomal rearrangements may lead to production of unbalanced gametes. As a result of a recombination event in the inversion loop, 2 recombinants with duplicated and deficient chromosome segments, including the regions distal to the inversion, may be produced. We report on 2 relatives in a family with opposite terminal chromosomal rearrangements of chromosome 10, i.e. rec(10)dup(10p)inv(10) and rec(10)dup(10q)inv(10), due to familial pericentric inversion inv(10)(p15.1q26.12). Based on array-CGH results, we characterized the exact genomic regions involved and compared the clinical features of both patients with previous reports on similar pericentric inversions and regional differences within 10p and 10q. The fact that both products of recombination are viable indicates a potentially high recurrence risk of unbalanced offspring. This report of unbalanced rearrangements in chromosome 10 in 2 generations confirms the importance of screening for terminal imbalances in patients with idiopathic intellectual disability by molecular cytogenetic techniques such as FISH, MLPA or microarrays. It also underlines the necessity for FISH to define structural characteristics of such cryptic intrachromosomal rearrangements and the underlying cytogenetic mechanisms. © 2014 S. Karger AG, Basel.

  6. 76 FR 22162 - Sixteenth Meeting: EUROCAE WG-72: RTCA Special Committee 216: Aeronautical Systems Security...

    Science.gov (United States)

    2011-04-20

    ... meeting held January 18-21, 2011. Report on the PMC/ICC Action on TOR. RTCA Specific Publication Progress... Advisory Committee. [FR Doc. 2011-9489 Filed 4-19-11; 8:45 am] BILLING CODE 4910-13-P ...

  7. Aquaregia and Oxygen Plasma Treatments on Fluorinated Tin Oxide for Assembly of PLEDs Devices Using OC1C10-PPV as Emissive Polymer

    Directory of Open Access Journals (Sweden)

    Emerson Roberto SANTOS

    2009-02-01

    Full Text Available In this work were carried out treatments with oxygen plasma and aquaregia on fluorinated tin oxide (FTO films varying the treatment times. After treatments, the samples were analyzed by techniques measurements: sheet resistance, thickness, Hall effect, transmittance and superficial roughness. Devices using FTO/PEDOT:PSS/OC1C10-PPV/Al were assembled. In this experiment some variations were observed by sheet resistance and thickness and Hall effect measurements indicated most elevated carriers concentration and resistivity for aquaregia than that oxygen plasma. The roughness was elevated for the first minutes with treatment by aquaregia too. In the I-V curves the aquaregia devices presented the lowest threshold voltage for 30 minutes and devices treated by oxygen plasma presented a behavior most resistivity different of typical curves for PLEDs devices.

  8. 78 FR 70567 - Center for Scientific Review; Amended Notice of Meeting

    Science.gov (United States)

    2013-11-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Institutes of Health, 6701 Rockledge Drive, Room 3091, Bethesda, MD, 20892 which was published in the Federal Register on September 18, 2013, 78 FR 57399. The meeting will be held at the Bethesda Marriott Hotel, 5151...

  9. 76 FR 70703 - Senior Executive Service: Membership of Performance Review Board

    Science.gov (United States)

    2011-11-15

    ...;and investigations, committee meetings, agency decisions and rulings, #0;delegations of authority..., Employee and Labor Relations Division. [FR Doc. 2011-29427 Filed 11-14-11; 8:45 am] BILLING CODE P ...

  10. Arsenic inhibits hedgehog signaling during P19 cell differentiation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jui Tung [Environmental Toxicology Program, Clemson University, 132 Long Hall, Clemson, SC 29634 (United States); Bain, Lisa J., E-mail: lbain@clemson.edu [Environmental Toxicology Program, Clemson University, 132 Long Hall, Clemson, SC 29634 (United States); Department of Biological Sciences, Clemson University, 132 Long Hall, Clemson, SC 29634 (United States)

    2014-12-15

    Arsenic is a toxicant found in ground water around the world, and human exposure mainly comes from drinking water or from crops grown in areas containing arsenic in soils or water. Epidemiological studies have shown that arsenic exposure during development decreased intellectual function, reduced birth weight, and altered locomotor activity, while in vitro studies have shown that arsenite decreased muscle and neuronal cell differentiation. The sonic hedgehog (Shh) signaling pathway plays an important role during the differentiation of both neurons and skeletal muscle. The purpose of this study was to investigate whether arsenic can disrupt Shh signaling in P19 mouse embryonic stem cells, leading to changes muscle and neuronal cell differentiation. P19 embryonic stem cells were exposed to 0, 0.25, or 0.5 μM of sodium arsenite for up to 9 days during cell differentiation. We found that arsenite exposure significantly reduced transcript levels of genes in the Shh pathway in both a time and dose-dependent manner. This included the Shh ligand, which was decreased 2- to 3-fold, the Gli2 transcription factor, which was decreased 2- to 3-fold, and its downstream target gene Ascl1, which was decreased 5-fold. GLI2 protein levels and transcriptional activity were also reduced. However, arsenic did not alter GLI2 primary cilium accumulation or nuclear translocation. Moreover, additional extracellular SHH rescued the inhibitory effects of arsenic on cellular differentiation due to an increase in GLI binding activity. Taken together, we conclude that arsenic exposure affected Shh signaling, ultimately decreasing the expression of the Gli2 transcription factor. These results suggest a mechanism by which arsenic disrupts cell differentiation. - Highlights: • Arsenic exposure decreases sonic hedgehog pathway-related gene expression. • Arsenic decreases GLI2 protein levels and transcriptional activity in P19 cells. • Arsenic exposure does not alter the levels of SHH

  11. Synthesis and Electrochemical Performance of SiOC-Carbon Nanotube Composite Coatings

    Science.gov (United States)

    Bhandavat, Romil; Cologna, Marco; Raj, Rishi; Singh, Gurpreet

    2012-02-01

    Rechargeable battery anodes made from crystalline Si-based nanostructures have been shown to possess high experimental first cycle capacities (3000 mAh/g), but face challenges in sustaining these capacities beyond initial cycles mainly due to large volume expansion (400 percent) and chemical degradation (pulverization). Polymer-derived ceramic SiOC due to its high thermodynamic stability and nano domain structure could present a viable alternative. Additionally, functionalization of SiOC with carbon nanotubes could result in increased electronic and ionic conductivities in the ceramic. Here, we demonstrate synthesis and electrochemical characterization of SiOC-CNT composite coatings for use in Li-ion battery anode. Materials characterization performed using electron microscopy, Infrared (FT-IR), and X-ray photoelectron spectroscopy suggests non-covalent functionalization of CNT with oxygen moieties in SiOC. Sustained battery capacities of over 700 mAh/g and first cycle columbic efficiencies of about 75 percent were achieved. Future work will involve determination of lithium ion intercalation sites characterized by electron microscopy whereas cyclic voltammetry analysis will access the sequential change in anode chemistry.

  12. Radioimmunoimaging of 99mTc-OC125 on experimental research and clinical application of ovarian cancer

    International Nuclear Information System (INIS)

    Zhang Hong; Xu Huimin; Wu Jinchang

    2000-03-01

    The objective of research is to investigate radioimmunoimaging (RII) on ovarian tumor by labelling anti-ovarian cancer monoclonal antibody (OC125) with 99m Tc. the nude mice models were produced by injection ovarian serous cyst adenocarcinoma cell HO8910. Experimental group was injected with 99m Tc-OC125 as tracer and control groups were injected normal mice IgG labelled with 99m Tc and anti-HO8910 antibody labelled with 99m Tc. RII using 99m Tc-OC125 McAb was also performed on 4 nude mice model of glioma (control group). Imaging positive rate, negative rate and tumor/non-tumor ratio were calculated. Results show positive rate of imaging of tumor was 100%. The most distinct pictures were gained between 4 to 6 h after injection of tracer. T/NT ratios of experimental group were higher than that of control groups (P 99m Tc on the nude mice models was sensitive and specific. 16 ovarian neoplasm patients were received RII 6 h after intravenous injected OC125 McAb labelled with 99m Tc. Four patients of malignant tumor repeated RII after operation and chemotherapy. The result of RII was accorded perfectly with operation. RII also can find micro recurrence focus of post-operation. The sensitivity and specificity was more excellent than the radioimmunoassay of CA125. RII is useful for defining character of ovarian tumor, especially for detecting early recurrence focus of post-operation patients

  13. Electric-dipole-coupled H2O@C60 dimer: Translation-rotation eigenstates from twelve-dimensional quantum calculations.

    Science.gov (United States)

    Felker, Peter M; Bačić, Zlatko

    2017-02-28

    We report on variational solutions to the twelve-dimensional (12D) Schrödinger equation appertaining to the translation-rotation (TR) eigenstates of H 2 O@C 60 dimer, associated with the quantized "rattling" motions of the two encapsulated H 2 O molecules. Both H 2 O and C 60 moieties are treated as rigid and the cage-cage geometry is taken to be fixed. We consider the TR eigenstates of H 2 O@C 60 monomers in the dimer to be coupled by the electric dipole-dipole interaction between water moieties and develop expressions for computing the matrix elements of that interaction in a dimer basis composed of products of monomer 6D TR eigenstates reported by us recently [P. M. Felker and Z. Bačić, J. Chem. Phys. 144, 201101 (2016)]. We use these expressions to compute TR Hamiltonian matrices of H 2 O@C 60 dimer for two values of the water dipole moment and for various dimer geometries. 12D TR eigenstates of the dimer are then obtained by filter diagonalization. The results reveal two classes of eigenstates, distinguished by the leading order (first or second) at which dipole-dipole coupling contributes to them. The two types of eigenstates differ in the general magnitude of their dipole-induced energy shifts and in the dependence of those shifts on the value of the water dipole moment and on the distance between the H 2 O@C 60 monomers. The dimer results are also found to be markedly insensitive to any change in the orientations of the C 60 cages. Finally, the results lend some support for the interpretation that electric dipole-dipole coupling is at least partially responsible for the apparent reduced-symmetry environment experienced by H 2 O in the powder samples of H 2 O@C 60 [K. S. K. Goh et al., Phys. Chem. Chem. Phys. 16, 21330 (2014)], but only if the water dipole is taken to have a magnitude close to that of free water. The methodology developed in the paper is transferable directly to the calculation of TR eigenstates of larger H 2 O@C 60 assemblies, that will

  14. 76 FR 70156 - Proposed 5-Year Outer Continental Shelf (OCS) Oil and Gas Leasing Program for 2012-2017

    Science.gov (United States)

    2011-11-10

    ... Analysis for the OCS 5-Year Program 2012-2017: Theory and Methodology (BOEM 050-2011), a paper containing a..., which remain the two areas of highest resource potential and interest, the Proposed Program schedules..., and setting the fiscal terms and conditions by individual lease sale, based on a current assessment of...

  15. 78 FR 31954 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-05-28

    ... Section. Date: June 20-21, 2013. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant... System Study Section. Date: June 20-21, 2013. Time: 8:00 a.m. to 10:00 a.m. Agenda: To review and... Antimicrobial Resistance Study Section. Date: June 20-21, 2013. Time: 8:00 a.m. to 6:00 p.m. Agenda: To review...

  16. Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability.

    Science.gov (United States)

    Kropp, Peter A; Dunn, Jennifer C; Carboneau, Bethany A; Stoffers, Doris A; Gannon, Maureen

    2018-04-01

    The transcription factors pancreatic and duodenal homeobox 1 (Pdx1) and onecut1 (Oc1) are coexpressed in multipotent pancreatic progenitors (MPCs), but their expression patterns diverge in hormone-expressing cells, with Oc1 expression being extinguished in the endocrine lineage and Pdx1 being maintained at high levels in β-cells. We previously demonstrated that cooperative function of these two factors in MPCs is necessary for proper specification and differentiation of pancreatic endocrine cells. In those studies, we observed a persistent decrease in expression of the β-cell maturity factor MafA. We therefore hypothesized that Pdx1 and Oc1 cooperativity in MPCs impacts postnatal β-cell maturation and function. Here our model of Pdx1-Oc1 double heterozygosity was used to investigate the impact of haploinsufficiency for both of these factors on postnatal β-cell maturation, function, and adaptability. Examining mice at postnatal day (P) 14, we observed alterations in pancreatic insulin content in both Pdx1 heterozygotes and double heterozygotes. Gene expression analysis at this age revealed significantly decreased expression of many genes important for glucose-stimulated insulin secretion (e.g., Glut2, Pcsk1/2, Abcc8) exclusively in double heterozygotes. Analysis of P14 islets revealed an increase in the number of mixed islets in double heterozygotes. We predicted that double-heterozygous β-cells would have an impaired ability to respond to stress. Indeed, we observed that β-cell proliferation fails to increase in double heterozygotes in response to either high-fat diet or placental lactogen. We thus report here the importance of cooperation between regulatory factors early in development for postnatal islet maturation and adaptability.

  17. Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Se-Jin [Department of Microbiology, Center for Metabolic Function Regulation (CMFR), Wonkwang University, College of Medicine, 460 Iksandae-ro, Iksan, Jeonbuk 570-749 (Korea, Republic of); Park, Channy [Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (United States); Lee, Joon No [Department of Microbiology, Center for Metabolic Function Regulation (CMFR), Wonkwang University, College of Medicine, 460 Iksandae-ro, Iksan, Jeonbuk 570-749 (Korea, Republic of); Lim, Hyewon; Hong, Gi-yeon [Department of Obstetrics and Gynecology, Wonkwang University, College of Medicine, 460 Iksandae-ro, Iksan, Jeonbuk 570-749 (Korea, Republic of); Moon, Sung K.; Lim, David J. [Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (United States); Choe, Seong-Kyu, E-mail: seongkyu642@wku.ac.kr [Department of Microbiology, Center for Metabolic Function Regulation (CMFR), Wonkwang University, College of Medicine, 460 Iksandae-ro, Iksan, Jeonbuk 570-749 (Korea, Republic of); Park, Raekil, E-mail: rkpark@wku.ac.kr [Department of Microbiology, Center for Metabolic Function Regulation (CMFR), Wonkwang University, College of Medicine, 460 Iksandae-ro, Iksan, Jeonbuk 570-749 (Korea, Republic of)

    2015-10-15

    Cisplatin has many adverse effects, which are a major limitation to its use, including ototoxicity, neurotoxicity, and nephrotoxicity. This study aims to elucidate the protective mechanisms of erdosteine against cisplatin in HEI-OC1 cells. Pretreatment with erdosteine protects HEI-OC1 cells from cisplatin-medicated apoptosis, which is characterized by increase in nuclear fragmentation, DNA laddering, sub-G{sub 0}/G{sub 1} phase, H2AX phosphorylation, PARP cleavage, and caspase-3 activity. Erdosteine significantly suppressed the production of reactive nitrogen/oxygen species and pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in cisplatin-treated cells. Studies using pharmacologic inhibitors demonstrated that phosphatidylinositol-3-kinases (PI3K) and protein kinase B (Akt) have protective roles in the action of erdosteine against cisplatin in HEI-OC1 cells. In addition, pretreatment with erdosteine clearly suppressed the phosphorylation of p53 (Ser15) and expression of p53-upregulated modulator of apoptosis. Erdosteine markedly induces expression of NF-E2-related factor 2 (Nrf2), which may contribute to the increase in expression of glutathione redox genes γ-L-glutamate-L-cysteine-ligase catalytic and γ-L-glutamate-L-cysteine-ligase modifier subunits, as well as in the antioxidant genes HO-1 and SOD2 in cisplatin-treated HEI-OC1 cells. Furthermore, the increase in expression of phosphorylated p53 induced by cisplatin is markedly attenuated by pretreatment with erdosteine in the mitochondrial fraction. This increased expression may inhibit the cytosolic expression of the apoptosis-inducing factor, cytochrome c, and Bax/Bcl-xL ratio. Thus, our results suggest that treatment with erdosteine is significantly attenuated cisplatin-induced damage through the activation of Nrf2-dependent antioxidant genes, inhibition of pro-inflammatory cytokines, activation of the PI3K/Akt signaling, and mitochondrial-related inhibition of pro

  18. Muistsed jumalad ühiskonna teenistuses : pseudomütoloogia Eesti avalikkuses 19. ja 20. sajandil / Ants Viires

    Index Scriptorium Estoniae

    Viires, Ants, 1918-2015

    2001-01-01

    Bibl. viidetes, lk. 519-520. Varem ilmunud: Ethnologia Europaea, 1991, nr. 21. Pealk.: Pseudomythology in Estonian publicity in the 19th and 20th century. Pseudomütoloogiliste kangelaste laiem levik algas Fr. R. Kreutzwaldi "Kalevipoja" ja Fr. R. Faehlmanni muistendite avaldamisega

  19. Establishment of a new human pre-B acute lymphoblastic leukemia cell line (KMO-90) with 1;19 translocation carrying p53 gene alterations.

    Science.gov (United States)

    Sotomatsu, M; Hayashi, Y; Kawamura, M; Yugami, S; Shitara, T

    1993-10-01

    A new human pre-B acute lymphoblastic leukemia cell line (KMO-90) was established from the bone marrow sample of a 12-year-old girl with acute lymphoblastic leukemia (ALL) carrying 1;19 chromosome translocation. KMO-90 cells expressed HLA-DR, CD10, CD19, and CD22 antigens. These cells had also cytoplasmic immunoglobulin lacking surface immunoglobulin, indicating that these had a pre-B phenotype. Chromosome analysis of this cell line showed 48, XX, +8, +19, t(1;19)(q23;p13). Southern blot analysis showed the same sized rearrangements of the E2A gene in KMO-90 cells as those in the original leukemic cells. By means of reverse transcriptase-polymerase chain reaction analysis, we detected E2A/PBX1 fusion transcripts in KMO-90 cells. KMO-90 is useful when studying the role of the 1;19 translocation in the etiology of pre-B ALL. Furthermore, we studied alterations of the p53 gene in this cell line by polymerase chain reaction, single-strand conformation polymorphism analysis. KMO-90 cells were identified to have a point mutation at codon 177 (CCC-->TCC) of the p53 gene, suggesting that alterations of the p53 gene may have an important role in the establishment of this cell line.

  20. 78 FR 31550 - Federal Acquisition Regulation; Submission for OMB Review; Travel Costs

    Science.gov (United States)

    2013-05-24

    ...; Submission for OMB Review; Travel Costs AGENCIES: Department of Defense (DOD), General Services... collection requirement concerning Travel Costs. A notice was published in the Federal Register at 77 FR 67366..., 2013. ADDRESSES: Submit comments identified by Information Collection 9000- 0088, Travel Costs by any...

  1. 78 FR 5449 - Federal Acquisition Regulation; Submission of OMB Review; Advance Payments

    Science.gov (United States)

    2013-01-25

    ...; Submission of OMB Review; Advance Payments AGENCIES: Department of Defense (DOD), General Services... requirement concerning advance payments. A notice was published in the Federal Register at 77 FR 43083, on... collection of information is necessary for the proper performance of functions of the Federal Acquisition...

  2. 77 FR 43812 - Information Collection; Submission for OMB Review, Comment Request

    Science.gov (United States)

    2012-07-26

    ... contextual and explanatory information (clarification of the data received from the annual program activity... Research and Evaluation. [FR Doc. 2012-18193 Filed 7-25-12; 8:45 am] BILLING CODE 6050-$$-P ...

  3. Exchange of carbonyl sulfide (OCS) between soils and atmosphere under various CO2 concentrations

    Science.gov (United States)

    Bunk, Rüdiger; Behrendt, Thomas; Yi, Zhigang; Andreae, Meinrat O.; Kesselmeier, Jürgen

    2017-06-01

    A new continuous integrated cavity output spectroscopy analyzer and an automated soil chamber system were used to investigate the exchange processes of carbonyl sulfide (OCS) between soils and the atmosphere under laboratory conditions. The exchange patterns of OCS between soils and the atmosphere were found to be highly dependent on soil moisture and ambient CO2 concentration. With increasing soil moisture, OCS exchange ranged from emission under dry conditions to an uptake within an optimum moisture range, followed again by emission at high soil moisture. Elevated CO2 was found to have a significant impact on the exchange rate and direction as tested with several soils. There is a clear tendency toward a release of OCS at higher CO2 levels (up to 7600 ppm), which are typical for the upper few centimeters within soils. At high soil moisture, the release of OCS increased sharply. Measurements after chloroform vapor application show that there is a biotic component to the observed OCS exchange. Furthermore, soil treatment with the fungi inhibitor nystatin showed that fungi might be the dominant OCS consumers in the soils we examined. We discuss the influence of soil moisture and elevated CO2 on the OCS exchange as a change in the activity of microbial communities. Physical factors such as diffusivity that are governed by soil moisture also play a role. Comparing KM values of the enzymes to projected soil water CO2 concentrations showed that competitive inhibition is unlikely for carbonic anhydrase and PEPCO but might occur for RubisCO at higher CO2 concentrations.

  4. 75 FR 55307 - Honey From the People's Republic of China: Preliminary Intent To Rescind New Shipper Reviews

    Science.gov (United States)

    2010-09-10

    ... Shipper Review, 75 FR 38980 (July 7, 2010). Expansion of the POR When the sale of the subject merchandise... review is based on a single sale, exclusion of that sale as non-bona fide necessarily must end the review... Shipper Review of Honey from the People's Republic of China: Bona Fide Analysis of the Sale Under Review...

  5. 77 FR 6114 - Agency Information Collection Activities; Proposed Collection; Comment Request; Extension

    Science.gov (United States)

    2012-02-07

    ...: 3084-0086); and (4) Regulations promulgated under The Truth-In-Lending Act, 15 U.S.C. 1601 et seq... college student credit card marketing. \\10\\ Regulation Z now requires card issuers to post and report...

  6. First evidences for 19F(α, p)22Ne at astrophysical energies

    International Nuclear Information System (INIS)

    D’Agata, G.; Spitaleri, C.; Pizzone, R.G.; Figuera, P.; Guardo, G.L.; Gulino, M.; Indelicato, I.; La Cognata, M.; Lattuada, M.; Sergi, M.L.; Blagus, S.; Mijatović, T.; Milin, M.; Miljanic, D.; Prepolec, L.; Skukan, N.; Grassi, L.; Lamia, L.; Hayakawa, S.; Kshetri, R.

    2016-01-01

    19 F experimental abundances is overestimated in respect to the theoretical one: it is therefore clear that further investigations are needed. We focused on the 19 F(α, p) 22 Ne reaction, representing the main destruction channel in He-rich environments. The lowest energy at which this reaction has been studied with direct methods is E C.M. ≈ 0.91 MeV, while the Gamow region is between 0.39 ÷ 0.8 MeV, far below the Coulomb barrier (3.8 MeV). For this reason, an experiment at Rudjer Boskovic Institute (Zagreb) was performed, applying the Trojan Horse Method. Following this method we selected the quasi-free contribution coming from 6 Li( 19 F,p 22 Ne) 2 H at E beam =6 MeV at kinematically favourable angles, and the cross section at energies 0 < E C.M. < 1.4 MeV was extracted in arbitrary units, covering the astrophysical region of interest. (paper)

  7. Thermonuclear 19F(p, {{\\boldsymbol{\\alpha }}}_{0})16O reaction rate

    Science.gov (United States)

    He, Jian-Jun; Lombardo, Ivano; Dell'Aquila, Daniele; Xu, Yi; Zhang, Li-Yong; Liu, Wei-Ping

    2018-01-01

    The thermonuclear 19F(p, {{{α }}}0)16O reaction rate in the temperature region 0.007-10 GK has been derived by re-evaluating the available experimental data, together with the low-energy theoretical R-matrix extrapolations. Our new rate deviates by up to about 30% compared to the previous results, although all rates are consistent within the uncertainties. At very low temperature (e.g. 0.01 GK) our reaction rate is about 20% lower than the most recently published rate, because of a difference in the low energy extrapolated S-factor and a more accurate estimate of the reduced mass used in the calculation of the reaction rate. At temperatures above ˜1 GK, our rate is lower, for instance, by about 20% around 1.75 GK, because we have re-evaluated the previous data (Isoya et al., Nucl. Phys. 7, 116 (1958)) in a meticulous way. The present interpretation is supported by the direct experimental data. The uncertainties of the present evaluated rate are estimated to be about 20% in the temperature region below 0.2 GK, and are mainly caused by the lack of low-energy experimental data and the large uncertainties in the existing data. Asymptotic giant branch (AGB) stars evolve at temperatures below 0.2 GK, where the 19F(p, {{α }})16O reaction may play a very important role. However, the current accuracy of the reaction rate is insufficient to help to describe, in a careful way, the fluorine over-abundances observed in AGB stars. Precise cross section (or S factor) data in the low energy region are therefore needed for astrophysical nucleosynthesis studies. Supported by National Natural Science Foundation of China (11490562, 11490560, 11675229) and National Key Research and Development Program of China (2016YFA0400503)

  8. DOE Lab-Wide Review of Fermilab May 19-20, 1987

    Energy Technology Data Exchange (ETDEWEB)

    Green, Dan [Fermilab

    1987-05-01

    This book is submitted as a written adjunct to the Annual DOE Lab-Wide Review of Fermilab, scheduled this year for May 19, 20, 1987. In it are described the functions and activities of the various laboratory areas plus statements of plans and goals for the coming year.

  9. Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis

    Directory of Open Access Journals (Sweden)

    Sophie A. Millar

    2017-07-01

    Full Text Available BackgroundOsteocalcin (OC is an intriguing hormone, concomitantly being the most abundant non-collagenous peptide found in the mineralized matrix of bone, and expanding the endocrine function of the skeleton with far-reaching extra-osseous effects. A new line of enquiry between OC and vascular calcification has emerged in response to observations that the mechanism of vascular calcification resembles that of bone mineralisation. To date, studies have reported mixed results. This systematic review and meta-analysis aimed to identify any association between OC and vascular calcification and atherosclerosis.Methods and resultsDatabases were searched for original, peer reviewed human studies. A total of 1,453 articles were retrieved, of which 46 met the eligibility criteria. Overall 26 positive, 17 negative, and 29 neutral relationships were reported for assessments between OC (either concentration in blood, presence of OC-positive cells, or histological staining for OC and extent of calcification or atherosclerosis. Studies that measured OC-positive cells or histological staining for OC reported positive relationships (11 studies. A higher percentage of Asian studies found a negative relationship (36% in contrast to European studies (6%. Studies examining carboxylated and undercarboxylated forms of OC in the blood failed to report consistent results. The meta-analysis found no significant difference between OC concentration in the blood between patients with “atherosclerosis” and control (p = 0.13, n = 1,197.ConclusionNo definitive association was determined between OC and vascular calcification or atherosclerosis; however, the presence of OC-positive cells and histological staining had a consistent positive correlation with calcification or atherosclerosis. The review highlighted several themes, which may influence OC within differing populations leading to inconclusive results. Large, longitudinal studies are required to further

  10. 77 FR 74512 - Interim Policy Leasing for Renewable Energy Data Collection Facility on the Outer Continental...

    Science.gov (United States)

    2012-12-14

    ... Company to conduct data collection and technology testing activities in one of the following ways: 1... Management Service, now BOEM, announced an interim policy for authorizing the issuance of leases for the installation of offshore data collection and technology testing facilities on the OCS (72 FR 62673). An...

  11. 78 FR 15046 - Certain Pasta From Italy and Turkey; Revised Schedule for the Subject Reviews

    Science.gov (United States)

    2013-03-08

    ... INTERNATIONAL TRADE COMMISSION [Investigation Nos. 701-TA-365-366 and 731-TA-734-735 (Third Review)] Certain Pasta From Italy and Turkey; Revised Schedule for the Subject Reviews AGENCY: United States... pasta from Italy and Turkey (78 FR 9937, February 12, 2013). The Commission is revising its schedule as...

  12. 22 CFR 19.6-5 - Preliminary review.

    Science.gov (United States)

    2010-04-01

    ... notify both parties to the divorce the reason a pro rata share payment is not payable. [46 FR 12958, Feb... certified copy of a final decree of divorce, PER/ER/RET will determine whether— (1) It is a valid decree... is or may become due the former spouse. If a divorce decree is deemed valid under this paragraph, a...

  13. 76 FR 54240 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-08-31

    ... Imaging Technology--A. Date: October 3-4, 2011. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Washington Plaza Hotel, 10 Thomas Circle, NW., Washington, DC 20005. Contact.... Agenda: To review and evaluate grant applications. Place: Washington Plaza Hotel, 10 Thomas Circle, NW...

  14. 75 FR 40819 - Records Governing Off-the-Record Communications; Public Notice

    Science.gov (United States)

    2010-07-14

    ...-24-10 Lee Emery.\\1\\ 2. P-739-000 6-15-10 Kristen Murphy.\\2\\ 3. P-2621-009 6-24-10 Alicia M. Rowe. 4... regarding Natural Dam hydroelectric project. Kimberly D. Bose, Secretary. [FR Doc. 2010-17098 Filed 7-13-10...

  15. The sdB pulsating star V391 Peg and its putative giant planet revisited after 13 years of time-series photometric data

    Science.gov (United States)

    Silvotti, R.; Schuh, S.; Kim, S.-L.; Lutz, R.; Reed, M.; Benatti, S.; Janulis, R.; Lanteri, L.; Østensen, R.; Marsh, T. R.; Dhillon, V. S.; Paparo, M.; Molnar, L.

    2018-04-01

    V391 Peg (alias HS 2201+2610) is a subdwarf B (sdB) pulsating star that shows both p- and g-modes. By studying the arrival times of the p-mode maxima and minima through the O-C method, in a previous article the presence of a planet was inferred with an orbital period of 3.2 years and a minimum mass of 3.2 MJup. Here we present an updated O-C analysis using a larger data set of 1066 h of photometric time series ( 2.5× larger in terms of the number of data points), which covers the period between 1999 and 2012 (compared with 1999-2006 of the previous analysis). Up to the end of 2008, the new O-C diagram of the main pulsation frequency (f1) is compatible with (and improves) the previous two-component solution representing the long-term variation of the pulsation period (parabolic component) and the giant planet (sine wave component). Since 2009, the O-C trend of f1 changes, and the time derivative of the pulsation period (p.) passes from positive to negative; the reason of this change of regime is not clear and could be related to nonlinear interactions between different pulsation modes. With the new data, the O-C diagram of the secondary pulsation frequency (f2) continues to show two components (parabola and sine wave), like in the previous analysis. Various solutions are proposed to fit the O-C diagrams of f1 and f2, but in all of them, the sinusoidal components of f1 and f2 differ or at least agree less well than before. The nice agreement found previously was a coincidence due to various small effects that are carefully analyzed. Now, with a larger dataset, the presence of a planet is more uncertain and would require confirmation with an independent method. The new data allow us to improve the measurement of p. for f1 and f2: using only the data up to the end of 2008, we obtain p.1 = (1.34 ± 0.04) × 10-12 and p.2 = (1.62 ± 0.22) × 10-12. The long-term variation of the two main pulsation periods (and the change of sign of p.1) is visible also in direct

  16. 17 CFR 240.10A-3 - Listing standards relating to audit committees.

    Science.gov (United States)

    2010-04-01

    ... management of one or more businesses which are conducted as a single economic enterprise; and (iii) Do not... any consulting, advisory, or other compensatory fee from the issuer or any subsidiary thereof...) Accept directly or indirectly any consulting, advisory, or other compensatory fee from the issuer or any...

  17. 75 FR 29211 - Changes in Flood Elevation Determinations

    Science.gov (United States)

    2010-05-25

    ..., Regulatory Planning and Review, 58 FR 51735. Executive Order 13132, Federalism. This final rule involves no...-0320P). 21, 2009; Rock Kaumo, Mayor, City of Springs Daily Rock Springs, 212 D Rocket[dash]Miner. Street...

  18. 77 FR 4541 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-01-30

    ... submit to the Office of Management and Budget (OMB) for clearance the following proposal for collection... reports, 60 minutes each; other notifications and reports, 10 minutes, and documentary evidence requests.... Gwellnar Banks, Management Analyst, Office of the Chief Information Officer. [FR Doc. 2012-1865 Filed 1-27...

  19. Force10 networks performance in world's first transcontinental 10 gigabit ethernet network verified by Ixia

    CERN Multimedia

    2003-01-01

    Force10 Networks, Inc., today announced that the performance of the Force10 E-Series switch/routers deployed in a transcontinental network has been verified as line-rate 10 GE throughput by Ixia, a leading provider of high-speed, network performance and conformance analysis systems. The network, the world's first transcontinental 10 GE wide area network, consists of a SURFnet OC-192 lambda between Geneva and the StarLight facility in Chicago via Amsterdam and another OC-192 lambda between this same facility in Chicago and Carleton University in Ottawa, Canada provided by CANARIE and ORANO (1/2 page).

  20. 78 FR 69703 - 10-Day Notice of Proposed Information Collection: Generic Customer Satisfaction Surveys; Physical...

    Science.gov (United States)

    2013-11-20

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5683-N-102] 10-Day Notice of Proposed Information Collection: Generic Customer Satisfaction Surveys; Physical Inspection Pilot Program...

  1. The crystal structure of Kirkiite, Pb10Bi3As3S19

    DEFF Research Database (Denmark)

    Makovicky, Emil; Balic Zunic, Tonci; Karanovic, Ljiljana

    2006-01-01

    and chemical analysis resulted in comparable formulae, Pb10Bi2.16As3.84S19 and Pb10.08Bi2.55Sb0.13As2.91S19, respectively, which are close to the ideal formula Pb10Bi3As3S19. The crystal lattice shows a pseudohexagonal symmetry, which is the cause of common twinning in this mineral. The main twin-law has (20...... layers parallel to (083) of kirkiite; the slabs are unit-cell-twinned on (010) refl ection planes. The structure contains one split As position, and two additional sites that could accommodate both As and Bi. The As,Bi distribution over these two sites is determined by the trapezoidal distortion...... of the half-octahedral coordination environment inside the tightly bonded double layers of the PbS-SnS archetype slabs. Owing to the stoichiometry requirements in this structure, Bi must also substitute for 1/11 of the Pb sites. Bond-valence calculations and the volumes of coordination polyhedra show...

  2. 77 FR 58381 - Depository Library Council to the Public Printer; Meeting

    Science.gov (United States)

    2012-09-20

    ... GOVERNMENT PRINTING OFFICE Depository Library Council to the Public Printer; Meeting The Depository Library Council to the Public Printer will meet on Monday, October 15, 2012 through Thursday... Printer of the United States. [FR Doc. 2012-23015 Filed 9-19-12; 8:45 am] BILLING CODE 1520-01-P ...

  3. 76 FR 30372 - Center for Scientific Review; Meetings

    Science.gov (United States)

    2011-05-25

    ... Panel; Member Conflict: Speech and Cognition. Date: June 9-10, 2011. Time: 11 a.m. to 5 p.m. Agenda: To....gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Emotion...

  4. Oral contraception following abortion

    Science.gov (United States)

    Che, Yan; Liu, Xiaoting; Zhang, Bin; Cheng, Linan

    2016-01-01

    Abstract Oral contraceptives (OCs) following induced abortion offer a reliable method to avoid repeated abortion. However, limited data exist supporting the effective use of OCs postabortion. We conducted this systematic review and meta-analysis in the present study reported immediate administration of OCs or combined OCs postabortion may reduce vaginal bleeding time and amount, shorten the menstruation recovery period, increase endometrial thickness 2 to 3 weeks after abortion, and reduce the risk of complications and unintended pregnancies. A total of 8 major authorized Chinese and English databases were screened from January 1960 to November 2014. Randomized controlled trials in which patients had undergone medical or surgical abortions were included. Chinese studies that met the inclusion criteria were divided into 3 groups: administration of OC postmedical abortion (group I; n = 1712), administration of OC postsurgical abortion (group II; n = 8788), and administration of OC in combination with traditional Chinese medicine postsurgical abortion (group III; n = 19,707). In total, 119 of 6160 publications were included in this analysis. Significant difference was observed in group I for vaginal bleeding time (P = 0.0001), the amount of vaginal bleeding (P = 0.03), and menstruation recovery period (P abortion (P abortion, and reduce the risk of complications and unintended pregnancies. PMID:27399060

  5. Long-term intensive management increased carbon occluded in phytolith (PhytOC) in bamboo forest soils

    Science.gov (United States)

    Huang, Zhang-Ting; Li, Yong-Fu; Jiang, Pei-Kun; Chang, Scott X.; Song, Zhao-Liang; Liu, Juan; Zhou, Guo-Mo

    2014-01-01

    Carbon (C) occluded in phytolith (PhytOC) is highly stable at millennium scale and its accumulation in soils can help increase long-term C sequestration. Here, we report that soil PhytOC storage significantly increased with increasing duration under intensive management (mulching and fertilization) in Lei bamboo (Phyllostachys praecox) plantations. The PhytOC storage in 0-40 cm soil layer in bamboo plantations increased by 217 Mg C ha-1, 20 years after being converted from paddy fields. The PhytOC accumulated at 79 kg C ha-1 yr-1, a rate far exceeding the global mean long-term soil C accumulation rate of 24 kg C ha-1 yr-1 reported in the literature. Approximately 86% of the increased PhytOC came from the large amount of mulch applied. Our data clearly demonstrate the decadal scale management effect on PhytOC accumulation, suggesting that heavy mulching is a potential method for increasing long-term organic C storage in soils for mitigating global climate change.

  6. Geologic and operational summary, COST No. G-2 well, Georges Bank area, North Atlantic OCS

    Science.gov (United States)

    Amato, Roger V.; Simonis, Edvardas K.

    1980-01-01

    The Continental Offshore Stratigraphic Test (COST) No. G-2 well is the second deep well to be drilled in the Georges Bank Basin and the third in a series of COST wells on the Atlantic Outer Continental Shelf (OCS). The G-2 was drilled by Ocean Production Company, acting as the operator for 19 participating companies between January 6 and August 30, 1977. The semisubmersible rig Ocean Victory was used to drill the well to a depth of 21,874 feet at a location 132 statute miles east-southeast of Nantucket Island in 272 feet of water. An earlier deep Stratigraphic test, the COST No. G-l well, was drilled 42 statute miles west of the G-2 well, to a depth of 16,071 feet in 1976 (fig. 1). Geological and engineering data obtained from the well were used by companies and the U.S. Geological Survey (USGS) for evaluating the petroleum potential and possible drilling problems in the U.S. North Atlantic OCS area in preparation for lease sale 42 held on December 18, 1979. The Stratigraphic test was intentionally drilled away from any potential petroleum-bearing feature, but in a block bordering several tracts that were included in the sale area.

  7. Oncogenic c-Myc-induced lymphomagenesis is inhibited non-redundantly by the p19Arf–Mdm2–p53 and RP–Mdm2–p53 pathways

    OpenAIRE

    Meng, X; Carlson, NR; Dong, J; Zhang, Y

    2015-01-01

    The multifaceted oncogene c-Myc plays important roles in the development and progression of human cancer. Recent in vitro and in vivo studies have shown that the p19Arf–Mdm2–p53 and the ribosomal protein (RP)–Mdm2–p53 pathways are both essential in preventing oncogenic c-Myc-induced tumorigenesis. Disruption of each pathway individually by p19Arf deletion or by Mdm2C305F mutation, which disrupts RP-Mdm2 binding, accelerates Eμ-myc transgene-induced pre-B/B-cell lymphoma in mice at seemingly s...

  8. Odontogenic and nonodontogenic cysts: An analysis of 526 cases in ...

    African Journals Online (AJOL)

    There were 406 (77.2%) inflammatory OCs and 103 (19.6%) developmental OCs. Radicular cysts were the most frequent (66.4%), followed by dentigerous (19.2%) and residual (10.8%) cysts. Only nasopalatine duct cyst was found as nOC in this study (3.2%). Conclusion: The distribution of jaw cysts in the Turkish Eastern ...

  9. 10 CFR 218.32 - Review.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Review. 218.32 Section 218.32 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Procedures § 218.32 Review. (a) Purpose and scope. This subpart establishes the procedures for the filing of an application for review of a supply order...

  10. 75 FR 6174 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-02-08

    ... submit to the Office of Management and Budget (OMB) for clearance the following proposal for collection... public employment program for the 2010 and 2011 Annual Survey of Public Employment & Payroll. The... Mickelson, Management Analyst, Office of the Chief Information Officer. [FR Doc. 2010-2658 Filed 2-5-10; 8...

  11. Multiple sexual partners and condom use among 10 - 19 year-olds in four districts in Tanzania: What do we learn?

    Directory of Open Access Journals (Sweden)

    Kweka Khadija

    2011-06-01

    Full Text Available Abstract Background Although some studies in Tanzania have addressed the question of sexuality and STIs among adolescents, mostly those aged 15 - 19 years, evidence on how multiple sexual partners influence condom use among 10 - 19 year-olds is limited. This study attempts to bridge this gap by testing a hypothesis that sexual relationships with multiple partners in the age group 10 - 19 years spurs condom use during sex in four districts in Tanzania. Methods Secondary analysis was performed using data from the Adolescents Module of the cross-sectional household survey on Maternal, Newborn and Child Health (MNCH that was done in Kigoma, Kilombero, Rufiji and Ulanga districts, Tanzania in 2008. A total of 612 adolescents resulting from a random sample of 1200 households participated in this study. Pearson Chi-Square was used as a test of association between multiple sexual partners and condom use. Multivariate logistic regression model was fitted to the data to assess the effect of multiple sexual partners on condom use, having adjusted for potential confounding variables. STATA (10 statistical software was used to carry out this process at 5% two-sided significance level. Results Of the 612 adolescents interviewed, 23.4% reported being sexually active and 42.0% of these reported having had multiple (> 1 sexual partners in the last 12 months. The overall prevalence of condom use among them was 39.2%. The proportion using a condom at the last sexual intercourse was higher among those who knew that they can get a condom if they want than those who did not. No evidence of association was found between multiple sexual partners and condom use (OR = 0.77, 95% CI = 0.35 - 1.67, P = 0.504. With younger adolescents (10 - 14 years being a reference, condom use was associated with age group (15 - 19: OR = 3.69, 95% CI = 1.21 - 11.25, P = 0.022 and district of residence (Kigoma: OR = 7.45, 95% CI = 1.79 - 31.06, P = 0.006; Kilombero: OR = 8.89, 95% CI = 2

  12. 76 FR 66309 - Pilot Program for Parallel Review of Medical Products; Correction

    Science.gov (United States)

    2011-10-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare and Medicaid Services [CMS-3180-N2] Food and Drug Administration [Docket No. FDA-2010-N-0308] Pilot Program for Parallel Review of Medical... 11, 2011 (76 FR 62808). The document announced a pilot program for sponsors of innovative device...

  13. 19p13.3 aberrations are associated with dysmorphic features and deviant psychomotor development.

    Science.gov (United States)

    Siggberg, L; Olsén, P; Näntö-Salonen, K; Knuutila, S

    2011-01-01

    Here, we describe 2 patients with de novo genomic imbalances of 19p13.3. Using high-resolution microarray analysis, we detected a 1.25-Mb deletion in one patient and a 0.81- Mb duplication in another. The resulting phenotypes are quite different; one is a 2-year-old boy with macrocephaly and normal growth, while the other is a 9-year-old boy with microcephaly and growth retardation since birth. Both have dysmorphic features and psychomotor developmental delay. This report gives evidence of the effect of small aberrations of chromosome 19 and describes the phenotypes arising from a duplication and deletion of the same location at 19p13.3. Copyright © 2010 S. Karger AG, Basel.

  14. Sources of the PM10 aerosol in Flanders, Belgium, and re-assessment of the contribution from wood burning.

    Science.gov (United States)

    Maenhaut, Willy; Vermeylen, Reinhilde; Claeys, Magda; Vercauteren, Jordy; Roekens, Edward

    2016-08-15

    From 30 June 2011 to 2 July 2012 PM10 aerosol samples were simultaneously taken every 4th day at four urban background sites in Flanders, Belgium. The sites were in Antwerpen, Gent, Brugge, and Oostende. The PM10 mass concentration was determined by weighing; organic and elemental carbon (OC and EC) were measured by thermal-optical analysis, the wood burning tracers levoglucosan, mannosan and galactosan were determined by gas chromatography/mass spectrometry, 8 water-soluble ions were measured by ion chromatography, and 15 elements were determined by a combination of inductively coupled plasma atomic emission spectrometry and mass spectrometry. The multi-species dataset was subjected to receptor modeling by PMF. The 10 retained factors (with their overall average percentage contributions to the experimental PM10 mass) were wood burning (9.5%), secondary nitrate (24%), secondary sulfate (12.6%), sea salt (10.0%), aged sea salt (19.2%), crustal matter (9.7%), non-ferrous metals (1.81%), traffic (10.3%), non-exhaust traffic (0.52%), and heavy oil burning (3.0%). The average contributions of wood smoke for the four sites were quite substantial in winter and ranged from 12.5 to 20% for the PM10 mass and from 47 to 64% for PM10 OC. Wood burning appeared to be also a notable source of As, Cd, and Pb. The contribution from wood burning to the PM10 mass and OC was also assessed by making use of levoglucosan as single marker compound and the conversion factors of Schmidl et al. (2008), as done in our previous study on wood burning in Flanders (Maenhaut et al., 2012). However, the apportionments were much lower than those deduced from PMF. It seems that the conversion factors of Schmidl et al. (2008) may not be applicable to wood burning in Flanders. From scatter plots of the PMF-derived wood smoke OC and PM versus levoglucosan, we arrived at conversion factors of 9.7 and 22.6, respectively. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Die kunjugative Verbrückung metallorganischer Reaktionszentren Heterozweikernkomplexen [(OC)3ClRe(.mu.-L)MCl(C5Me5)]+, M=Rh oder Ir Spektroskopische Konsequenzen reduktiver Aktivierung

    Czech Academy of Sciences Publication Activity Database

    Kaim, W.; Scheiring, T.; Weber, M.; Fiedler, Jan

    2004-01-01

    Roč. 630, - (2004), s. 1883-1893 ISSN 0044-2313 R&D Projects: GA MŠk OC D15.10; GA MŠk OC D14.20 Institutional research plan: CEZ:AV0Z4040901 Keywords : electrochemistry * iridium * rhenium Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.086, year: 2004

  16. 78 FR 69701 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-11-20

    ... Review Special Emphasis Panel; Bacterial Transcription and Regulation. Date: December 16, 2013. Time: 2... and Reproduction. Date: December 18, 2013. Time: 10:00 a.m. to 6:00 p.m. Agenda: To review and...

  17. Gestational food restriction decreases placental interleukin-10 expression and markers of autophagy and endoplasmic reticulum stress in murine intrauterine growth restriction.

    Science.gov (United States)

    Chu, Alison; Thamotharan, Shanthie; Ganguly, Amit; Wadehra, Madhuri; Pellegrini, Matteo; Devaskar, Sherin U

    2016-10-01

    Intrauterine growth restriction (IUGR) affects up to 10% of pregnancies and often results in short- and long-term sequelae for offspring. The mechanisms underlying IUGR are poorly understood, but it is known that healthy placentation is essential for nutrient provision to fuel fetal growth, and is regulated by immunologic inputs. We hypothesized that in pregnancy, maternal food restriction (FR) resulting in IUGR would decrease the overall immunotolerant milieu in the placenta, leading to increased cellular stress and death. Our specific objectives were to evaluate (1) key cytokines (eg, IL-10) that regulate maternal-fetal tolerance, (2) cellular processes (autophagy and endoplasmic reticulum [ER] stress) that are immunologically mediated and important for cellular survival and functioning, and (3) the resulting IUGR phenotype and placental histopathology in this animal model. After subjecting pregnant mice to mild and moderate FR from gestational day 10 to 19, we collected placentas and embryos at gestational day 19. We examined RNA sequencing data to identify immunologic pathways affected in IUGR-associated placentas and validated messenger RNA expression changes of genes important in cellular integrity. We also evaluated histopathologic changes in vascular and trophoblastic structures as well as protein expression changes in autophagy, ER stress, and apoptosis in the mouse placentas. Several differentially expressed genes were identified in FR compared with control mice, including a considerable subset that regulates immune tolerance, inflammation, and cellular integrity. In summary, maternal FR decreases the anti-inflammatory effect of IL-10 and suppresses placental autophagic and ER stress responses, despite evidence of dysregulated vascular and trophoblast structures leading to IUGR. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Meeting of the Technical Working Group on Fast Reactors (TWG-FR) (39th annual meeting). Working material

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The 39th Annual Meeting of the Technical Working Group on Fast Reactors (TWG FR) was held from 15-19 May 2006 in Beijing, China, at the invitation of the China Institute of Atomic Energy (CIAEA). The meeting was attended by TWG-FR Members and Advisers from the following Member States (MS): Belgium (observer), Brazil, China, France, Germany, India, Italy, Japan, the Republic of Kazakhstan, the Republic of Korea, the Russian Federation, Sweden (observer), the United Kingdom, and the United States. Belarus, Switzerland, the European Commission, and OECD/NEA were unable to participate. Moreover, Prof. Carlo Rubbia, CERN director general emeritus, participated, upon IAEA invitation, in the meeting as distinguished scientist and IAEA expert. Mr. S.C. Chetal, from India (Indira Gandhi Centre for Atomic Research, IGCAR), was appointed chairman. The objectives of the meeting were to: - Exchange information on the national programmes on Fast Reactors (FR) and Accelerator Driven Systems (ADS); - Review the progress since the 38th TWG-FR Annual Meeting, including the status of the actions; - Consider meeting arrangements for 2006 and 2007; - Reviewed the Agency's ongoing information exchange and co-ordinated research activities in the technical fields relevant to the TWG-FR (FRs and ADS), as well as co-ordination of the TWG-FR's activities with other organizations; - Discuss future joint activities in view of the Agency's Programme and Budget Cycle 2008-2009 (and beyond)

  19. A brief overview of the Chemistry-Aerosol Mediterranean Experiment (ChArMEx) database and campaign operation centre (ChOC)

    Science.gov (United States)

    Ferré, Hélène; Dulac, François; Belmahfoud, Nizar; Brissebrat, Guillaume; Cloché, Sophie; Descloitres, Jacques; Fleury, Laurence; Focsa, Loredana; Henriot, Nicolas; Ramage, Karim; Vermeulen, Anne

    2016-04-01

    Initiated in 2010 in the framework of the multidisciplinary research programme MISTRALS (Mediterranean Integrated Studies at Regional and Local Scales; http:www.mistrals-home.org), the Chemistry-Aerosol Mediterranean Experiment (ChArMEx, http://charmex.lsce.ipsl.fr/) aims at federating the scientific community for an updated assessment of the present and future state of the atmospheric environment in the Mediterranean Basin, and of its impacts on the regional climate, air quality, and marine biogeochemistry. The project combines mid- and long-term monitoring, intensive field campaigns, use of satellite data, and modelling studies. In this presentation we provide an overview of the campaign operation centre (http://choc.sedoo.fr/) and project database (http://mistrals.sedoo.fr/ChArMEx), at the end of the first experimental phase of the project that included a series of large campaigns based on airborne means (including balloons and various aircraft) and a network of surface stations. Those campaigns were performed mainly in the western Mediterranean basin in the summer of 2012, 2013 and 2014 with the help of the ChArMEx Operation Centre (ChOC), an open web site that has the objective to gather and display daily quick-looks from model forecasts and near-real time in situ and remote sensing observations of physical and chemical weather conditions relevant for the everyday campaign operation decisions. The ChOC is also useful for post campaign analyses and can be completed with a number of quick-looks of campaign results obtained later in order to offer an easy access to, and comprehensive view of all available data during the campaign period. The items included are selected according to the objectives and location of the given campaigns. The second experimental phase of ChArMEx from 2015 on is more focused on the eastern basin. In addition, the project operation centre is planned to be adapted for a joint MERMEX-ChArMEx oceanographic cruise (PEACETIME) for a study at

  20. 76 FR 1169 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Science.gov (United States)

    2011-01-07

    ... submit a license application for FDA review and approval prior to marketing a biological product for introduction into interstate commerce. In the Federal Register of November 30, 2004 (69 FR 69606), FDA...

  1. Ionic and carbonaceous compositions of PM10, PM2.5 and PM1.0 at Gosan ABC Superstation and their ratios as source signature

    Directory of Open Access Journals (Sweden)

    S. Kim

    2012-02-01

    Full Text Available PM1.0, PM2.5, and PM10 were sampled at Gosan ABC Superstation on Jeju Island from August 2007 to September 2008. The carbonaceous aerosols were quantified with the thermal/optical reflectance (TOR method, which produced five organic carbon (OC fractions, OC1, OC2, OC3, OC4, and pyrolyzed organic carbon (OP, and three elemental carbon (EC fractions, EC1, EC2, and EC3. The mean mass concentrations of PM1.0, PM2.5, and PM10 were 13.7 μg m−3, 17.2 μg m−3, and 28.4 μg m−3, respectively. The averaged mass fractions of OC and EC were 23.0% and 10.4% for PM1.0, 22.9% and 9.8% for PM2.5, and 16.4% and 6.0% for PM10. Among the OC and EC sub-components, OC2 and EC2+3 were enriched in the fine mode, but OC3 and OC4 in the coarse mode. The filter-based PM1.0 EC agreed well with black carbon (BC measured by an Aethalometer, and PM10 EC was higher than BC, implying less light absorption by larger particles. EC was well correlated with sulfate, resulting in good relationships of sulfate with both aerosol scattering coefficient measured by Nephelometer and BC concentration. Our measurements of EC confirmed the definition of EC1 as char-EC emitted from smoldering combustion and EC2+3 as soot-EC generated from higher-temperature combustion such as motor vehicle exhaust and coal combustion (Han et al., 2010. In particular, EC1 was strongly correlated with potassium, a traditional biomass burning indicator, except during the summer, when the ratio of EC1 to EC2+3 was the lowest. We also found the ratios of major chemical species to be a useful tool to constrain the main sources of aerosols, by which the five air masses were well distinguished: Siberia, Beijing, Shanghai, Yellow Sea, and East Sea types. Except Siberian air, the continental background of the study region, Beijing plumes showed the highest EC1 (and OP to sulfate ratio, which implies that this air mass had the highest net warming by aerosols of the four air masses. Shanghai-type air, which was

  2. 78 FR 72139 - Reporting and Recordkeeping Requirements Under OMB Review

    Science.gov (United States)

    2013-12-02

    ... Affairs, Office of Management and Budget, New Executive Office Building, Washington, DC 20503. FOR FURTHER... resulted in changes related to franchise eligibility, character determinations, credit standards, and... Curtis Rich, Management Analyst. [FR Doc. 2013-28805 Filed 11-29-13; 8:45 am] BILLING CODE 8025-01-P ...

  3. Non-Serotonergic Neurotoxicity by MDMA (Ecstasy in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells.

    Directory of Open Access Journals (Sweden)

    Dina Popova

    Full Text Available 3,4-methylenedioxymethamphetamine (MDMA; ecstasy is a commonly abused recreational drug that causes neurotoxic effects in both humans and animals. The mechanism behind MDMA-induced neurotoxicity is suggested to be species-dependent and needs to be further investigated on the cellular level. In this study, the effects of MDMA in neuronally differentiated P19 mouse embryonal carcinoma cells have been examined. MDMA produces a concentration-, time- and temperature-dependent toxicity in differentiated P19 neurons, as measured by intracellular MTT reduction and extracellular LDH activity assays. The P19-derived neurons express both the serotonin reuptake transporter (SERT, that is functionally active, and the serotonin metabolizing enzyme monoamine oxidase A (MAO-A. The involvement of these proteins in the MDMA-induced toxicity was investigated by a pharmacological approach. The MAO inhibitors clorgyline and deprenyl, and the SERT inhibitor fluoxetine, per se or in combination, were not able to mimic the toxic effects of MDMA in the P19-derived neurons or block the MDMA-induced cell toxicity. Oxidative stress has been implicated in MDMA-induced neurotoxicity, but pre-treatment with the antioxidants α-tocopherol or N-acetylcysteine did not reveal any protective effects in the P19 neurons. Involvement of mitochondria in the MDMA-induced cytotoxicity was also examined, but MDMA did not alter the mitochondrial membrane potential (ΔΨm in the P19 neurons. We conclude that MDMA produce a concentration-, time- and temperature-dependent neurotoxicity and our results suggest that the mechanism behind MDMA-induced toxicity in mouse-derived neurons do not involve the serotonergic system, oxidative stress or mitochondrial dysfunction.

  4. Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells.

    Science.gov (United States)

    Popova, Dina; Forsblad, Andréas; Hashemian, Sanaz; Jacobsson, Stig O P

    2016-01-01

    3,4-methylenedioxymethamphetamine (MDMA; ecstasy) is a commonly abused recreational drug that causes neurotoxic effects in both humans and animals. The mechanism behind MDMA-induced neurotoxicity is suggested to be species-dependent and needs to be further investigated on the cellular level. In this study, the effects of MDMA in neuronally differentiated P19 mouse embryonal carcinoma cells have been examined. MDMA produces a concentration-, time- and temperature-dependent toxicity in differentiated P19 neurons, as measured by intracellular MTT reduction and extracellular LDH activity assays. The P19-derived neurons express both the serotonin reuptake transporter (SERT), that is functionally active, and the serotonin metabolizing enzyme monoamine oxidase A (MAO-A). The involvement of these proteins in the MDMA-induced toxicity was investigated by a pharmacological approach. The MAO inhibitors clorgyline and deprenyl, and the SERT inhibitor fluoxetine, per se or in combination, were not able to mimic the toxic effects of MDMA in the P19-derived neurons or block the MDMA-induced cell toxicity. Oxidative stress has been implicated in MDMA-induced neurotoxicity, but pre-treatment with the antioxidants α-tocopherol or N-acetylcysteine did not reveal any protective effects in the P19 neurons. Involvement of mitochondria in the MDMA-induced cytotoxicity was also examined, but MDMA did not alter the mitochondrial membrane potential (ΔΨm) in the P19 neurons. We conclude that MDMA produce a concentration-, time- and temperature-dependent neurotoxicity and our results suggest that the mechanism behind MDMA-induced toxicity in mouse-derived neurons do not involve the serotonergic system, oxidative stress or mitochondrial dysfunction.

  5. Technical meeting (TM) to 'Review of national programmes on fast reactors and accelerator driven systems (ADS)'. Technical Working Group on Fast Reactors (TWG-FR) (37th annual meeting). Working material

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    The objectives of the 37th Annual Meeting of the Technical Working Group on Fast Reactors, were to: 1) exchange information on the national programmes on Fast Reactors (FR) and Accelerator Driven Systems (ADS); 2) review the progress since the 36th TWG-FR Annual Meeting, including the status of the actions; 3) consider meeting arrangements for 2004 and 2005; 4) review the Agency's co-ordinated research activities in the field of FRs and ADS, as well as co-ordination of the TWG-FR's activities with other organizations. The participants made presentations on the status of the respective national programmes on FR and ADS development. A summary of the highlights for the period since the 36th TWG-FR Annual Meeting is included in this proceedings. Annex IV contains the Review of National Programs on Fast Reactors and Accelerator Driven Systems (ADS), and the TWG-FR Activity Report for the Period May 2003-April 2004.

  6. Quemaduras por frío: Revisión de 10 Años

    OpenAIRE

    EULUFÍ M, ALEX; PIÑEROS B, JOSÉ LUIS; CALDERÓN O, WILFREDO; CUADRA C, ÁLVARO; DANILLA E, STEFAN; LÉNIZ M, PATRICIO; ROCO M, HÉCTOR; ROA G, RICARDO; EULUFÍ M, CHRISTIAN

    2006-01-01

    La injuria por frío ha sido objeto de estudio desde la década de 1960, Este trabajo entrega los resultados de una revisión retrospectiva de un grupo de 10 pacientes ingresados al Hospital del Trabajador de Santiago (HTS) en un periodo de 10 años producto de accidentes laborales de distintas etiologías. Cabe señalar que solo encontramos reportes aislados de casos en la literatura revisada. Se revisaron retrospectivamente las fichas clínicas de 10 pacientes en el periodo 1993-2003. Las edades f...

  7. Is Real-World Evidence Used in P&T Monographs and Therapeutic Class Reviews?

    Science.gov (United States)

    Hurwitz, Jason T; Brown, Mary; Graff, Jennifer S; Peters, Loretta; Malone, Daniel C

    2017-06-01

    Payers are faced with making coverage and reimbursement decisions based on the best available evidence. Often these decisions apply to patient populations, provider networks, and care settings not typically studied in clinical trials. Treatment effectiveness evidence is increasingly available from electronic health records, registries, and administrative claims. However, little is known about when and what types of real-world evidence (RWE) studies inform pharmacy and therapeutic (P&T) committee decisions. To evaluate evidence sources cited in P&T committee monographs and therapeutic class reviews and assess the design features and quality of cited RWE studies. A convenience sample of representatives from pharmacy benefit management, health system, and health plan organizations provided recent P&T monographs and therapeutic class reviews (or references from such documents). Two investigators examined and grouped references into major categories (published studies, unpublished studies, and other/unknown) and multiple subcategories (e.g., product label, clinical trials, RWE, systematic reviews). Cited comparative RWE was reviewed to assess design features (e.g., population, data source, comparators) and quality using the Good ReseArch for Comparative Effectiveness (GRACE) Checklist. Investigators evaluated 565 references cited in 27 monographs/therapeutic class reviews from 6 managed care organizations. Therapeutic class reviews mostly cited published clinical trials (35.3%, 155/439), while single-product monographs relied most on manufacturer-supplied information (42.1%, 53/126). Published RWE comprised 4.8% (21/439) of therapeutic class review references, and none (0/126) of the monograph references. Of the 21 RWE studies, 12 were comparative and assessed patient care settings and outcomes typically not included in clinical trials (community ambulatory settings [10], long-term safety [8]). RWE studies most frequently were based on registry data (6), conducted in

  8. Spontaneous hemoperitoneum in pregnancy (SHiP) and endometriosis - A systematic review of the recent literature.

    Science.gov (United States)

    Lier, Marit C I; Malik, Romana F; Ket, Johannes C F; Lambalk, Cornelis B; Brosens, Ivo A; Mijatovic, Velja

    2017-12-01

    Spontaneous Hemoperitoneum in Pregnancy (SHiP), an unprovoked (nontraumatic) intraperitoneal bleeding in pregnancy (up to 42days postpartum), is associated with serious adverse pregnancy outcomes. To evaluate the clinical consequences of SHiP and its association with endometriosis, a systematic review was conducted according to the PRISMA guidelines. PubMed, Embase.com and Thomson Reuters/Web of Science were searched for articles published since the latest review (August 2008) until September 2016. After assessment for eligibility, forty-four articles were included in this systematic review, describing 59 cases of SHiP. Endometriosis was present in 33/59 cases (55.9%), most often diagnosed prior to pregnancy. An association between the severity of SHiP and the stage of endometriosis could not be found. In the majority of cases, SHiP occurred in the third trimester of pregnancy (30/59 cases (50.8%)); women presented with (sub)acute abdominal pain (56/59 cases (94.9%)), hypovolemic shock (28/59 cases (47.5%)) and/or a decreased level of hemoglobin (37/59 cases (62.7%)). Signs of fetal distress were observed in 24/59 cases (40.7%). Imaging confirmed free peritoneal fluid in (37/59 cases (62.7%)). At time of surgery active bleeding was revealed in 51/56 cases (91,1%), originating from endometriotic implants (11/51 cases (21.6%)), ruptured utero-ovarian vessels (29/51 cases (56.8%)), hemorrhagic nodules of decidualized cells (1/51 cases (2.0%)) or a combination (10/51 cases (19.6%)). Median amount of hemoperitoneum was 1600mL (IQR 1000mL-2500mL). From the 45/59 cases (76.3%) in which surgical interventions was carried out during pregnancy, 7/45 cases (15.6%) reported a successful continuation of pregnancy. 5/59 cases reported recurrence of SHiP (recurrence rate 8.5%). The perinatal mortality rate was 26.9% (18/67 fetus), one maternal death was reported (1/59 cases (1,7%)). In conclusion, SHiP is a very serious complication of pregnancy, highly associated with adverse

  9. 77 FR 55851 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-09-11

    ..., [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Systems Development Study Section. Date: October 10-11, 2012. Time: 8 a.m. to 5 p.m. Agenda: To review and...

  10. 75 FR 71122 - Erie Boulevard Hydropower L.P.; Notice of Scoping Meetings and Environmental Site Review

    Science.gov (United States)

    2010-11-22

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 7518-012--New York] Erie Boulevard Hydropower L.P.; Notice of Scoping Meetings and Environmental Site Review November 15, 2010. Commission staff will be conducting two public scoping meetings and an environmental site review in support...

  11. 77 FR 65447 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-10-26

    ... burden estimate, or any other aspect of the information collection, including suggestion for reducing the... contact information from individuals who may be interested in working for the IRS now, or at any time in... Hours: 66,085. Dawn D. Wolfgang, Treasury PRA Clearance Officer. [FR Doc. 2012-26346 Filed 10-25-12; 8...

  12. Infrared Spectroscopy of Two Isomers of the OCS-CS_{2} Complex

    Science.gov (United States)

    Oliaee, J. N.; Dehghany, M.; Afshari, Mahin; Moazzen-Ahmadi, N.; McKellar, A. R. W.

    2009-06-01

    A second isomer of OCS-CS_{2} complex, with a nonplanar cross-shaped structure, has been studied for the first time by analysing an infrared band in the region of the OCS stretching vibration (2062 cm^{-1}). This isomer has C_{s} symmetry and the observed band consists of purely c-type rotational transitions. The ground state rotational parameters are found to be A=0.07306 cm^{-1}, B=0.03325 cm^{-1} and C=0.02879 cm^{-1}, in good agreement with a previous semi-empirical calculation. In addition, a hybrid band with a- and b-type rotational transitions has been assigned to be due to the known planar form of OCS-CS_{2}, as previously studied by microwave spectroscopy. The spectra were recorded using a rapid-scan tunable diode laser spectrometer to probe a pulsed supersonic jet expansion. Calculations indicate that the planar isomer of OCS-CS_{2} is the lowest in energy, in contrast to CO_{2}-CS_{2} where the crossed form is believed to be the lowest. J. J. Newby, M. M. Serafin, R. A. Peebles and S. A. Peebles, Phys. Chem. Chem. Phys. 7, 487 (2005). C. C. Dutton, D. A. Dows, R. Eikey, S. Evans and R. A. Beaudet, J. Phys. Chem. A 102, 6904 (1998).

  13. A high-resolution study of the sup 20 Ne( sup 3 He,t) sup 20 Na reaction and the sup 19 Ne(p,. gamma. ) sup 20 Na reaction rate

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M S; Magnus, P V; Hahn, K I; Howard, A J; Parker, P D [A.W. Wright Nuclear Structure Lab., Yale Univ., New Haven, CT (United States); Champagne, A E; Mao, Z Q [Dept. of Physics, Princeton Univ., NJ (United States)

    1992-01-13

    A high-precision measurement of the {sup 20}Ne({sup 3}He,t){sup 20}Na reaction has been made using implanted {sup 20}Ne transmission targets to obtain pertinent information on the low-energy resonances in the {sup 19}Ne(p,{gamma}){sup 20}Na reaction. Resonance energies (447{+-}5, 658{+-}5, 787{+-}5, and 857{+-}5 keV) and upper limits on total intrinsic widths (<10, <6, <10, and <16 keV) have been measured for four excited states above the 2.199 MeV proton threshold in {sup 20}Na. The stellar {sup 19}Ne(p,{gamma}){sup 20}Na reaction rate is calculated for temperatures between 1x10{sup 8} and 1x10{sup 9} K. When combined with a recent study of the {sup 15}O({alpha},{gamma}){sup 19}Ne reaction, a new estimate is made of the conditions required for breakout from the Hot CNO cylce to the rapid proton capture process. (orig.).

  14. Characterization and origin of EC and OC particulate matter near the Doñana National Park (SW Spain).

    Science.gov (United States)

    de la Campa, A M Sánchez; Pio, C; de la Rosa, J D; Querol, X; Alastuey, A; González-Castanedo, Y

    2009-08-01

    In the South of Spain, major industrial estates (e.g. Huelva) exist alongside ecologically interesting zones (e.g. Doñana National Park). Between June 2005 and June 2006, PM10 and PM2.5 were measured, for total mass, organic carbon (OC) and elemental carbon (EC) chemical composition, at a station in an ecologically interesting area located near Doñana National Park and an urban background area with industrial influence. The mean OC concentration is higher in the urban background (3.5 microg m(-3)) than in the rural monitoring station (2.8 microg m(-3)) as a consequence of local emissions (e.g. traffic). A total of 82% of TC is OC in the rural station, while the urban background station reveals 70% and 73% of TC in the PM10 and PM2.5 mass, respectively. The study of air-mass origin and characterization of carbonaceous species in the course of simultaneous sampling in rural and urban background monitoring stations differentiated three long-range air-mass transports: a North-African dust outbreak, Atlantic Advection and Continental (N-NW) episodes, the origins of the first and last of which are more heavily influenced by the anthropogenic emissions from industrial estates located around the city of Huelva (Punta del Sebo and Nuevo Puerto). Higher values were measured for OC and EC in the study area during the North-African dust outbreak, similar to those obtained during the Continental episode (N-NW), which was clearly influenced by industrial emissions, followed by the Atlantic Advection episodes. The comparison of carbon species with air-mass origin can help to discriminate the origin and source of particulate matter, as well as to determine the urban impact on rural areas.

  15. 77 FR 51033 - Center For Scientific Review; Notice of Closed Meeting

    Science.gov (United States)

    2012-08-23

    ...: Biochemistry. Date: August 27, 2012. Time: 10:45 a.m. to 12:15 p.m. Agenda: To review and evaluate grant... Conference Call). Contact Person: Nuria E. Assa-Munt, Ph.D., Scientific Review Officer, Center for Scientific...

  16. GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.

    Directory of Open Access Journals (Sweden)

    Ying Zhou

    Full Text Available BACKGROUND: Our previous studies showed a down-regulation of GRIM-19 in primary human cervical cancers, and restoration of GRIM-19 induced tumor regression. The induction of tumor suppressor protein p53 ubiquitination and degradation by E6 oncoportein of high risk-HPV through forming a stable complex with E6AP is considered as a critical mechanism for cervical tumor development. The aims of this study were to determine the potential role of GRIM-19 in rescuing p53 protein and inducing cervical cancer cell apoptosis. METHODOLOGY/PRINCIPAL FINDINGS: The protein levels of GRIM-19 and p53 were detected in normal cervical tissues from 45 patients who underwent hysterectomy for reasons other than neoplasias of either the cervix or endometrium, and cervical cancer tissues from 60 patients with non-metastatic squamous epithelial carcinomas. Coimmunoprecipitation and GST pull-down assay were performed to examine the interaction of GRIM-19 with 18E6 and E6AP in vivo and in vitro respectively. The competition of 18E6 with E6AP in binding GRIM-19 by performing competition pull-down assays was designed to examine the disruption of E6/E6AP complex by GRIM-19. The augment of E6AP ubiquitination by GRIM-19 was detected in vivo and in vitro ubiquitination assay. The effects of GRIM-19-dependent p53 accumulation on cell proliferation, cell cycle, apoptosis were explored by MTT, flow cytometry and transmission electron microscopy respectively. The tumor suppression was detected by xenograft mouse model. CONCLUSION/SIGNIFICANCE: The levels of GRIM-19 and p53 were concurrently down regulated in cervical cancers. The restoration of GRIM-19 can induce ubiquitination and degradation of E6AP, and disrupt the E6/E6AP complex through the interaction of N-terminus of GRIM-19 with both E6 and E6AP, which protected p53 from degradation and promoted cell apoptosis. Tumor xenograft studies also revealed the suppression of p53 degradation in presence of GRIM-19. These data

  17. 77 FR 43812 - Information Collection; Submission for OMB Review, Comment Request

    Science.gov (United States)

    2012-07-26

    ... device for the deaf (TTY-TDD) may call 1-800-833-3722 between 8:00 a.m. and 8:00 p.m. Eastern Time...): None. Dated: July 20, 2012. Paul Davis, Director of Program Development, AmeriCorps VISTA. [FR Doc...

  18. 78 FR 66372 - Center for Scientific Review; Amended Notice of Meeting

    Science.gov (United States)

    2013-11-05

    ... September 05, 2013, 78 FR 54664-54665. The meeting will be held at the Hotel Monaco Baltimore, 2 North Charles Street, Baltimore, MD 21201 on November 22, 2013, starting at 08:00 a.m. and ending at 07:00 p.m...

  19. 78 FR 66030 - Center for Scientific Review; Amended Notice of Meeting

    Science.gov (United States)

    2013-11-04

    ... Register on September 09, 2013, 78 FR 174 Pgs. 55086- 55087. The meeting will be held at the Ritz-Carlton Hotel, 1150 22nd Street NW., Washington, DC 20037. The meeting will start on December 12, 2013 at 4:30 p...

  20. 77 FR 25506 - Submission for Review: Expiring Information Collection, Interview Survey Form, INV 10

    Science.gov (United States)

    2012-04-30

    ... OFFICE OF PERSONNEL MANAGEMENT Submission for Review: Expiring Information Collection, Interview... collection request (ICR), Office of Management and Budget (OMB) Control No. 3206- 0106, for the Interview[email protected] . SUPPLEMENTARY INFORMATION: The Interview Survey Form, INV 10, is a questionnaire that OPM...

  1. A systematic review of the effect of oral glucocorticoids on energy intake, appetite, and body weight in humans.

    Science.gov (United States)

    Berthon, Bronwyn S; MacDonald-Wicks, Lesley K; Wood, Lisa G

    2014-03-01

    Obesity is a serious risk factor for chronic disease, and commonly prescribed oral glucocorticoids (OCS) may be contributing to the prevalence of obesity. The objective of this review was to assess the impact of OCS on obesity in humans through effects on body weight (BW), energy intake, appetite, and body composition. An electronic search of English language peer-reviewed studies from 1973 up to March 2012 was conducted using Medline, CINAHL, EMBASE, and Cochrane databases. Original studies that addressed the effects of OCS on appetite, energy intake, BW, or body composition in adults were considered eligible. Data from 21 studies with objectively measured outcomes were extracted and assessed for quality using standardized tools. The publication year varied from 1986 to 2013, and the sample size, from 6 to 189. Energy intake was measured in 6 studies; BW, in 19 studies; energy expenditure, in 3 studies; body composition, in 6 studies; and appetite was evaluated in 3 studies. Short-term oral glucocorticoid therapy may result in small increases in energy intake but does not appear to result in increased BW, possibly due to an increase in energy expenditure. Long-term therapy may result in clinically significant weight gain. Within-subject variation due to metabolism and physical activity levels confounds the relationship. A dose-response relationship of oral glucocorticoid therapy on energy intake, appetite, BW, or body composition was not found. Additional well-designed, double-blind, placebo-controlled clinical trials that use standardized doses of OCS and assess the effects on appetite, energy intake, BW, and composition are strongly justified to confirm the findings of this review. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. 25 CFR 256.19 - Who performs the improvements, repairs, or replacement of my dwelling?

    Science.gov (United States)

    2010-04-01

    ... my dwelling? 256.19 Section 256.19 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... dwelling? Independent or tribal repair or construction trades persons, home building contractors, or construction companies will perform the repairs, renovation, or replacement of your dwelling. [63 FR 10134, Mar...

  3. Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation.

    Science.gov (United States)

    Hosoi, Yoshio; Uno, Yasuhiro; Murayama, Norie; Fujino, Hideki; Shukuya, Mitsunori; Iwasaki, Kazuhide; Shimizu, Makiko; Utoh, Masahiro; Yamazaki, Hiroshi

    2012-12-15

    Cynomolgus monkeys are widely used as primate models in preclinical studies. However, some differences are occasionally seen between monkeys and humans in the activities of cytochrome P450 enzymes. R- and S-warfarin are model substrates for stereoselective oxidation in humans. In this current research, the activities of monkey liver microsomes and 14 recombinantly expressed monkey cytochrome P450 enzymes were analyzed with respect to R- and S-warfarin 6- and 7-hydroxylation. Monkey liver microsomes efficiently mediated both R- and S-warfarin 7-hydroxylation, in contrast to human liver microsomes, which preferentially catalyzed S-warfarin 7-hydroxylation. R-Warfarin 7-hydroxylation activities in monkey liver microsomes were not inhibited by α-naphthoflavone or ketoconazole, and were roughly correlated with P450 2C19 levels and flurbiprofen 4-hydroxylation activities in microsomes from 20 monkey livers. In contrast, S-warfarin 7-hydroxylation activities were not correlated with the four marker drug oxidation activities used. Among the 14 recombinantly expressed monkey P450 enzymes tested, P450 2C19 had the highest activities for R- and S-warfarin 7-hydroxylations. Monkey P450 3A4 and 3A5 slowly mediated R- and S-warfarin 6-hydroxylations. Kinetic analysis revealed that monkey P450 2C19 had high V(max) and low K(m) values for R-warfarin 7-hydroxylation, comparable to those for monkey liver microsomes. Monkey P450 2C19 also mediated S-warfarin 7-hydroxylation with V(max) and V(max)/K(m) values comparable to those for recombinant human P450 2C9. R-warfarin could dock favorably into monkey P450 2C19 modeled. These results collectively suggest high activities for monkey liver P450 2C19 toward R- and S-warfarin 6- and 7-hydroxylation in contrast to the saturation kinetics of human P450 2C9-mediated S-warfarin 7-hydroxylation. Copyright © 2012 Elsevier Inc. All rights reserved.

  4. 78 FR 18342 - Federal Acquisition Regulation; Submission for OMB Review; Change Order Accounting

    Science.gov (United States)

    2013-03-26

    ...; Submission for OMB Review; Change Order Accounting AGENCY: Department of Defense (DOD), General Services... requirement concerning change order accounting. A notice was published in the Federal Register at 77 FR 51804... Collection 9000- 0026, Change Order Accounting, by any of the following methods: Regulations.gov : http://www...

  5. 77 FR 58103 - Federal Acquisition Regulation; Submission for OMB Review; Corporate Aircraft Costs

    Science.gov (United States)

    2012-09-19

    ... is determined that an upward adjustment is not required at this time. The historical estimates remain...; Submission for OMB Review; Corporate Aircraft Costs AGENCY: Department of Defense (DOD), General Services... requirement concerning corporate aircraft costs. A notice was published in the Federal Register at 77 FR 20012...

  6. 75 FR 74069 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-11-30

    ...--Infectious Diseases and Microbiology. Date: December 10, 2010. Time: 1 p.m. to 5 p.m. Agenda: To review and... of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research...

  7. 76 FR 58265 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Science.gov (United States)

    2011-09-20

    ... for review and approval according to the procedures prescribed in 5 CFR 1320.12. On May 9, 2011 (76 FR... of processes used to adjust and improve the physical and aesthetic characteristics of the leather...

  8. Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.

    Science.gov (United States)

    Sherman, D A; Pasion, S G; Forsburg, S L

    1998-07-01

    The members of the MCM protein family are essential eukaryotic DNA replication factors that form a six-member protein complex. In this study, we use antibodies to four MCM proteins to investigate the structure of and requirements for the formation of fission yeast MCM complexes in vivo, with particular regard to Cdc19p (MCM2). Gel filtration analysis shows that the MCM protein complexes are unstable and can be broken down to subcomplexes. Using coimmunoprecipitation, we find that Mis5p (MCM6) and Cdc21p (MCM4) are tightly associated with one another in a core complex with which Cdc19p loosely associates. Assembly of Cdc19p with the core depends upon Cdc21p. Interestingly, there is no obvious change in Cdc19p-containing MCM complexes through the cell cycle. Using a panel of Cdc19p mutants, we find that multiple domains of Cdc19p are required for MCM binding. These studies indicate that MCM complexes in fission yeast have distinct substructures, which may be relevant for function.

  9. 16 CFR 1.19 - Modification of a rule by the Commission at the time of judicial review.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Modification of a rule by the Commission at the time of judicial review. 1.19 Section 1.19 Commercial Practices FEDERAL TRADE COMMISSION... event that a reviewing court determines under section 18(e)(2) of the Federal Trade Commission Act, to...

  10. Activation of endogenous p53 by combined p19Arf gene transfer and nutlin-3 drug treatment modalities in the murine cell lines B16 and C6

    Directory of Open Access Journals (Sweden)

    Zanatta Daniela B

    2010-06-01

    Full Text Available Abstract Background Reactivation of p53 by either gene transfer or pharmacologic approaches may compensate for loss of p19Arf or excess mdm2 expression, common events in melanoma and glioma. In our previous work, we constructed the pCLPG retroviral vector where transgene expression is controlled by p53 through a p53-responsive promoter. The use of this vector to introduce p19Arf into tumor cells that harbor p53wt should yield viral expression of p19Arf which, in turn, would activate the endogenous p53 and result in enhanced vector expression and tumor suppression. Since nutlin-3 can activate p53 by blocking its interaction with mdm2, we explored the possibility that the combination of p19Arf gene transfer and nutlin-3 drug treatment may provide an additive benefit in stimulating p53 function. Methods B16 (mouse melanoma and C6 (rat glioma cell lines, which harbor p53wt, were transduced with pCLPGp19 and these were additionally treated with nutlin-3 or the DNA damaging agent, doxorubicin. Viral expression was confirmed by Western, Northern and immunofluorescence assays. p53 function was assessed by reporter gene activity provided by a p53-responsive construct. Alterations in proliferation and viability were measured by colony formation, growth curve, cell cycle and MTT assays. In an animal model, B16 cells were treated with the pCLPGp19 virus and/or drugs before subcutaneous injection in C57BL/6 mice, observation of tumor progression and histopathologic analyses. Results Here we show that the functional activation of endogenous p53wt in B16 was particularly challenging, but accomplished when combined gene transfer and drug treatments were applied, resulting in increased transactivation by p53, marked cell cycle alteration and reduced viability in culture. In an animal model, B16 cells treated with both p19Arf and nutlin-3 yielded increased necrosis and decreased BrdU marking. In comparison, C6 cells were quite susceptible to either treatment, yet

  11. Activation of endogenous p53 by combined p19Arf gene transfer and nutlin-3 drug treatment modalities in the murine cell lines B16 and C6

    International Nuclear Information System (INIS)

    Merkel, Christian A; Silva Soares, Rafael B da; Carvalho, Anna Carolina V de; Zanatta, Daniela B; Bajgelman, Marcio C; Fratini, Paula; Costanzi-Strauss, Eugenia; Strauss, Bryan E

    2010-01-01

    Reactivation of p53 by either gene transfer or pharmacologic approaches may compensate for loss of p19Arf or excess mdm2 expression, common events in melanoma and glioma. In our previous work, we constructed the pCLPG retroviral vector where transgene expression is controlled by p53 through a p53-responsive promoter. The use of this vector to introduce p19Arf into tumor cells that harbor p53wt should yield viral expression of p19Arf which, in turn, would activate the endogenous p53 and result in enhanced vector expression and tumor suppression. Since nutlin-3 can activate p53 by blocking its interaction with mdm2, we explored the possibility that the combination of p19Arf gene transfer and nutlin-3 drug treatment may provide an additive benefit in stimulating p53 function. B16 (mouse melanoma) and C6 (rat glioma) cell lines, which harbor p53wt, were transduced with pCLPGp19 and these were additionally treated with nutlin-3 or the DNA damaging agent, doxorubicin. Viral expression was confirmed by Western, Northern and immunofluorescence assays. p53 function was assessed by reporter gene activity provided by a p53-responsive construct. Alterations in proliferation and viability were measured by colony formation, growth curve, cell cycle and MTT assays. In an animal model, B16 cells were treated with the pCLPGp19 virus and/or drugs before subcutaneous injection in C57BL/6 mice, observation of tumor progression and histopathologic analyses. Here we show that the functional activation of endogenous p53wt in B16 was particularly challenging, but accomplished when combined gene transfer and drug treatments were applied, resulting in increased transactivation by p53, marked cell cycle alteration and reduced viability in culture. In an animal model, B16 cells treated with both p19Arf and nutlin-3 yielded increased necrosis and decreased BrdU marking. In comparison, C6 cells were quite susceptible to either treatment, yet p53 was further activated by the combination of p19

  12. Fate and effects of nearshore discharges of OCS produced waters. Volume 2. Technical report (Final)

    International Nuclear Information System (INIS)

    Rabalais, N.N.; McKee, B.A.; Reed, D.J.; Means, J.C.

    1991-06-01

    While the number of facilities that discharge OCS produced waters into coastal environments of Louisiana are few in number, they account for large volumes, individually and collectively. Of the 15 facilities which discharge OCS-generated produced water into coastal environments of Louisiana (as of February 1990), 10 discharges in seven areas were studied. The discharge volumes of the study areas range from 3,000 to 106,000/bbl.d. The receiving environments for these effluents are varied, but include the shallow, nearshore continental shelf; high energy, freshwater distributaries of the Mississippi River delta; and brackish and saline coastal environments with moderately to poorly flushed waters. All study areas are within the Mississippi River Deltaic Plain. The study expanded on the initial assessment of Boesch and Rabalais (1989a) with increased temporal and spatial studies of three areas, additional study sites including an abandoned discharge, and additional analytical and field observations

  13. 76 FR 60934 - Proposal Review Panel for Human Resource Development; Notice of Meeting

    Science.gov (United States)

    2011-09-30

    ... NATIONAL SCIENCE FOUNDATION Proposal Review Panel for Human Resource Development; Notice of...; Proposal Review Panel Human Resource Development ( 1199). Date/Time: November 1, 2011; 5 p.m. to 10 p.m...: Part-Open. Contact Person: Kelly Mack, Division of Human Resource Development, Room 815, National...

  14. Competitive bidding for OCS leases and environmental risk

    International Nuclear Information System (INIS)

    Englin, J.E.; Klan, M.S.

    1990-01-01

    In the last few years, the role of environment has become increasingly contentious in the process of competitive bidding for exploration and development rights of offshore petroleum leases in the outer continental shelf (OCS). Although an extensive literature exists on OCS leasing per se, relatively little work focuses on the role of environmental factors. This paper examines the effect on environmental risk on the number of firms (or joint ventures) entering bids for a given tract, which relates to the effective competition for the tracts. The next section outlines a theoretical model of bidding behavior under environmental risk. The third section presents the data used to estimate the model. The fourth section gives empirical results of an analysis of Sale No. 42, conducted in 1979 for Georges Bank in the North Atlantic. The last section provides concluding remarks

  15. Store skadar på poppel

    OpenAIRE

    Talgø, Venche; Sletten, Arild; Gjærum, Halvor B.; Stensvand, Arne

    2009-01-01

    I vekstsesongen 2007 kom det inn fleire rapportar frå Oslo og omegn om poppel (Populus spp.) med visne blad og greiner. Gjennom prosjektet ”Planter for norsk klima” undersøkte vi i 2008 poppel frå fleire lokalitetar på Austlandet og fann ulike skadar. Også poppel frå to lokalitetar i Rogaland vart undersøkte. Store tre stod med visne greiner stikkande ut frå nærast bladlause kroner. Mest alvorleg var kreftsår på greiner og stammer som etter alt å døma skuldast bakterien Xanthomonas populi. I ...

  16. 76 FR 70470 - Extension of Agency Information Collection Activity Under OMB Review: Law Enforcement Officer...

    Science.gov (United States)

    2011-11-14

    ...This notice announces that the Transportation Security Administration (TSA) has forwarded the Information Collection Request (ICR), Office of Management and Budget (OMB) control number 1652-0034, abstracted below to OMB for review and approval of an extension of the currently approved collection under the Paperwork Reduction Act (PRA). The ICR describes the nature of the information collection and its expected burden. TSA published a Federal Register notice, with a 60-day comment period soliciting comments, of the following collection of information on August 10, 2011, 76 FR 49504. The collection involves TSA gathering information from Territorial, Tribal, Federal, municipal, county, state, and authorized railroad law enforcement agencies who have requested the Law Enforcement Officer (LEO) Flying Armed training course.

  17. 78 FR 64981 - Agency Information Collection Activities; Submission for OMB Review; Comment Request...

    Science.gov (United States)

    2013-10-30

    ... seeking to use foreign crewmembers for longshore work when no U.S. workers are available. This ICR has... process for both the stakeholder community interested in these collections and the Federal staff reviewing... notice published in the Federal Register on August 8, 2013 (78 FR 48463). Interested parties are...

  18. Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer.

    Science.gov (United States)

    Majchrzak-Baczmańska, Dominika B; Głowacka, Ewa; Wilczyński, Miłosz; Malinowski, Andrzej

    2018-03-01

    The aim of the study was to compare serum concentration of soluble L- and P-selectins in women with ovarian cancer (OC) and healthy controls, and to investigate sL- and sP-selectin levels with regard to clinical and pathological parameters. Correlation analysis was used to measure the following: sL- and sP-selectin concentration and Ca125; sP-selectin and platelet concentrations; and sL-selectin and serum leukocyte levels in women with OC. The study included 29 patients with OC and 23 healthy controls. Serum concentrations of sL- and sP-selectins were measured in all subjects. Routine diagnostic tests: CBC and USG (both groups) and Ca125 (study group) were performed. Significantly higher serum concentrations of sL- and sP-selectins were found in the study group as compared to controls. Lower levels of serum sL-selectin were observed in women with poorly-differentiated OC (G3) and advanced stages of the disease (FIGO III, IV), but the results were statistically insignificant. No statistically significant relationship was detected between sP-selectin serum concentration in women with OC and tumour differentiation, histological type, and stage of the disease. No significant correlation was found between sL- and sP-selectins and Ca125 levels. A weak correlation was found between serum concentration of sP-selectin in women with OC and platelet count. No statistically significant correlation was observed between sL-selectin concentration and serum leukocyte levels in women with OC. The analysis of sL- and sP-selectin concentrations may be a useful tool in the diagnosis of OC. The levels of sL-selectin decrease with disease progression.

  19. Identification and expression analysis of two interleukin-23α (p19) isoforms, in rainbow trout Oncorhynchus mykiss and Atlantic salmon Salmo salar.

    Science.gov (United States)

    Jiang, Yousheng; Husain, Mansourah; Qi, Zhitao; Bird, Steve; Wang, Tiehui

    2015-08-01

    Interleukin (IL)-23 is a heterodimeric IL-12 family cytokine composed of a p19 α-chain, linked to a p40 β-chain that is shared with IL-12. IL-23 is distinguished functionally from IL-12 by its ability to induce the production of IL-17, and differentiation of Th17 cells in mammals. Three isoforms of p40 (p40a, p40b and p40c) have been found in some 3R teleosts. Salmonids also possess three p40 isoforms (p40b1, p40b2 and p40c) although p40a is missing, and two copies (paralogues) of p40b are present that have presumably been retained following the 4R duplication in this fish lineage. Teleost p19 has been discovered recently in zebrafish, but to date there is limited information on expression and modulation of this molecule. In this report we have cloned two p19 paralogues (p19a and p19b) in salmonids, suggesting that a salmonid can possess six potential IL-23 isoforms. Whilst Atlantic salmon has two active p19 genes, the rainbow trout p19b gene may have been pseudogenized. The salmonid p19 translations share moderate identities (22.8-29.9%) to zebrafish and mammalian p19 molecules, but their identity was supported by structural features, a conserved 4 exon/3 intron gene organisation, and phylogenetic tree analysis. The active salmonid p19 genes are highly expressed in blood and gonad. Bacterial (Yersinia ruckeri) and viral infection in rainbow trout induces the expression of p19a, suggesting pathogen-specific induction of IL-23 isoforms. Trout p19a expression was also induced by PAMPs (poly IC and peptidoglycan) and the proinflammatory cytokine IL-1β in primary head kidney macrophages. These data may indicate diverse functional roles of trout IL-23 isoforms in regulating the immune response in fish. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Drug kinetics release from Eudragit – Tenofovir@SiOC tablets

    Energy Technology Data Exchange (ETDEWEB)

    Tamayo, A., E-mail: aitanath@icv.csic.es [Ceramics and Glass Institute, CSIC, Madrid (Spain); Mazo, M.A. [Ceramics and Glass Institute, CSIC, Madrid (Spain); Veiga, M.D.; Ruiz-Caro, R.; Notario-Pérez, F. [Dpt. Pharmaceutical Technology, Faculty of Pharmacy, Complutense University of Madrid, Madrid (Spain); Rubio, J. [Ceramics and Glass Institute, CSIC, Madrid (Spain)

    2017-06-01

    A novel drug release system has been obtained in form of tablets from Eudragit® RS and tenofovir loaded on porous silicon oxycarbide glasses (SiOC). Active carbon (AC) and mesoporous silica (MCM-41) have also been used for comparative purposes. The porous silicon oxycarbide presents a bimodal mesopore size distribution that is maintained after functionalization with amino groups. We have studied the adsorption kinetics and adsorption equilibrium when the materials are loaded with tenofovir and, in all cases, pseudo-second order kinetics and Langmuir isotherm have been revealed as the most representative models describing the kinetic and thermodynamic parameters. Besides, the tenofovir adsorption on these materials turns out to be a favorable process. In vitro release of tenofovir has been studied in simulated vaginal medium by applying different release models. Continuous tenofovir release for > 20 days has been obtained for the SiOC material functionalized with amine groups. We concluded that the drug release occurs in two steps that involve a drug diffusion step through the material pores and diffusion through the swollen polymer. The interactions between the tenofovir drug and de amine groups of the functionalized silicon oxycarbide also play an important role in the release process. - Highlights: • Kinetic and thermodinamic parameters of the adsorption of tenofovir on porous substrates have been obtained. • Sustained release of TFV for > 20 days in SVF when it is supported on SiOC and manufactured as Eudragit®RS-containing tablets. • Release described by a two-step process involving diffusion through SiOC matrix and subsequent diffusion through the polymer.