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Sample records for fr18oc10r basis reporting

  1. Safety Basis Report

    R.J. Garrett

    2002-01-01

    As part of the internal Integrated Safety Management Assessment verification process, it was determined that there was a lack of documentation that summarizes the safety basis of the current Yucca Mountain Project (YMP) site characterization activities. It was noted that a safety basis would make it possible to establish a technically justifiable graded approach to the implementation of the requirements identified in the Standards/Requirements Identification Document. The Standards/Requirements Identification Documents commit a facility to compliance with specific requirements and, together with the hazard baseline documentation, provide a technical basis for ensuring that the public and workers are protected. This Safety Basis Report has been developed to establish and document the safety basis of the current site characterization activities, establish and document the hazard baseline, and provide the technical basis for identifying structures, systems, and components (SSCs) that perform functions necessary to protect the public, the worker, and the environment from hazards unique to the YMP site characterization activities. This technical basis for identifying SSCs serves as a grading process for the implementation of programs such as Conduct of Operations (DOE Order 5480.19) and the Suspect/Counterfeit Items Program. In addition, this report provides a consolidated summary of the hazards analyses processes developed to support the design, construction, and operation of the YMP site characterization facilities and, therefore, provides a tool for evaluating the safety impacts of changes to the design and operation of the YMP site characterization activities

  2. Safety Basis Report

    R.J. Garrett

    2002-01-14

    As part of the internal Integrated Safety Management Assessment verification process, it was determined that there was a lack of documentation that summarizes the safety basis of the current Yucca Mountain Project (YMP) site characterization activities. It was noted that a safety basis would make it possible to establish a technically justifiable graded approach to the implementation of the requirements identified in the Standards/Requirements Identification Document. The Standards/Requirements Identification Documents commit a facility to compliance with specific requirements and, together with the hazard baseline documentation, provide a technical basis for ensuring that the public and workers are protected. This Safety Basis Report has been developed to establish and document the safety basis of the current site characterization activities, establish and document the hazard baseline, and provide the technical basis for identifying structures, systems, and components (SSCs) that perform functions necessary to protect the public, the worker, and the environment from hazards unique to the YMP site characterization activities. This technical basis for identifying SSCs serves as a grading process for the implementation of programs such as Conduct of Operations (DOE Order 5480.19) and the Suspect/Counterfeit Items Program. In addition, this report provides a consolidated summary of the hazards analyses processes developed to support the design, construction, and operation of the YMP site characterization facilities and, therefore, provides a tool for evaluating the safety impacts of changes to the design and operation of the YMP site characterization activities.

  3. Authorization basis requirements comparison report

    Brantley, W.M.

    1997-08-18

    The TWRS Authorization Basis (AB) consists of a set of documents identified by TWRS management with the concurrence of DOE-RL. Upon implementation of the TWRS Basis for Interim Operation (BIO) and Technical Safety Requirements (TSRs), the AB list will be revised to include the BIO and TSRs. Some documents that currently form part of the AB will be removed from the list. This SD identifies each - requirement from those documents, and recommends a disposition for each to ensure that necessary requirements are retained when the AB is revised to incorporate the BIO and TSRs. This SD also identifies documents that will remain part of the AB after the BIO and TSRs are implemented. This document does not change the AB, but provides guidance for the preparation of change documentation.

  4. Authorization basis requirements comparison report

    Brantley, W.M.

    1997-01-01

    The TWRS Authorization Basis (AB) consists of a set of documents identified by TWRS management with the concurrence of DOE-RL. Upon implementation of the TWRS Basis for Interim Operation (BIO) and Technical Safety Requirements (TSRs), the AB list will be revised to include the BIO and TSRs. Some documents that currently form part of the AB will be removed from the list. This SD identifies each - requirement from those documents, and recommends a disposition for each to ensure that necessary requirements are retained when the AB is revised to incorporate the BIO and TSRs. This SD also identifies documents that will remain part of the AB after the BIO and TSRs are implemented. This document does not change the AB, but provides guidance for the preparation of change documentation

  5. 14 CFR 152.315 - Reporting on accrual basis.

    2010-01-01

    ...) AIRPORTS AIRPORT AID PROGRAM Accounting and Reporting Requirements § 152.315 Reporting on accrual basis. (a... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Reporting on accrual basis. 152.315 Section... financial reports on an accrual basis. (b) If records are not maintained on an accrual basis by a sponsor or...

  6. PARFUME Theory and Model basis Report

    Darrell L. Knudson; Gregory K Miller; G.K. Miller; D.A. Petti; J.T. Maki; D.L. Knudson

    2009-09-01

    The success of gas reactors depends upon the safety and quality of the coated particle fuel. The fuel performance modeling code PARFUME simulates the mechanical, thermal and physico-chemical behavior of fuel particles during irradiation. This report documents the theory and material properties behind vari¬ous capabilities of the code, which include: 1) various options for calculating CO production and fission product gas release, 2) an analytical solution for stresses in the coating layers that accounts for irradiation-induced creep and swelling of the pyrocarbon layers, 3) a thermal model that calculates a time-dependent temperature profile through a pebble bed sphere or a prismatic block core, as well as through the layers of each analyzed particle, 4) simulation of multi-dimensional particle behavior associated with cracking in the IPyC layer, partial debonding of the IPyC from the SiC, particle asphericity, and kernel migration (or amoeba effect), 5) two independent methods for determining particle failure probabilities, 6) a model for calculating release-to-birth (R/B) ratios of gaseous fission products that accounts for particle failures and uranium contamination in the fuel matrix, and 7) the evaluation of an accident condition, where a particle experiences a sudden change in temperature following a period of normal irradiation. The accident condi¬tion entails diffusion of fission products through the particle coating layers and through the fuel matrix to the coolant boundary. This document represents the initial version of the PARFUME Theory and Model Basis Report. More detailed descriptions will be provided in future revisions.

  7. 75 FR 3666 - Basis Reporting by Securities Brokers and Basis Determination for Stock; Correction

    2010-01-22

    ... Basis Reporting by Securities Brokers and Basis Determination for Stock; Correction AGENCY: Internal... on Thursday, December 17, 2009, relating to reporting sales of securities by brokers and determining... 3, in the preamble, under paragraph heading ``a. Form and Manner of New Broker Reporting...

  8. Exploratory Shaft Facility design basis study report

    Langstaff, A.L.

    1987-01-01

    The Design Basis Study is a scoping/sizing study that evaluated the items concerning the Exploratory Shaft Facility Design including design basis values for water and methane inflow; flexibility of the design to support potential changes in program direction; cost and schedule impacts that could result if the design were changed to comply with gassy mine regulations; and cost, schedule, advantages and disadvantages of a larger second shaft. Recommendations are proposed concerning water and methane inflow values, facility layout, second shaft size, ventilation, and gassy mine requirements. 75 refs., 3 figs., 7 tabs

  9. 76 FR 78182 - Basis Reporting by Securities Brokers and Basis Determination for Debt Instruments and Options...

    2011-12-16

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Part 1 [REG-102988-11] RIN 1545-BK05 Basis Reporting by Securities Brokers and Basis Determination for Debt Instruments and Options..., November 25, 2011 (76 FR 72652) relating to reporting by brokers for transactions related to debt...

  10. Authorization basis status report (miscellaneous TWRS facilities, tanks and components)

    Stickney, R.G.

    1998-04-29

    This report presents the results of a systematic evaluation conducted to identify miscellaneous TWRS facilities, tanks and components with potential needed authorization basis upgrades. It provides the Authorization Basis upgrade plan for those miscellaneous TWRS facilities, tanks and components identified.

  11. Authorization basis status report (miscellaneous TWRS facilities, tanks and components)

    Stickney, R.G.

    1998-01-01

    This report presents the results of a systematic evaluation conducted to identify miscellaneous TWRS facilities, tanks and components with potential needed authorization basis upgrades. It provides the Authorization Basis upgrade plan for those miscellaneous TWRS facilities, tanks and components identified

  12. 75 FR 75896 - Basis Reporting by Securities Brokers and Basis Determination for Stock

    2010-12-07

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR 1 [TD 9504] RIN 1545-BI66 Basis Reporting by Securities Brokers and Basis Determination for Stock Correction In rule document 2010-25504 beginning on page 64072 in the issue of Monday, October 18, 2010, make the following corrections: Sec. 1...

  13. 75 FR 6166 - Basis Reporting by Securities Brokers and Basis Determination for Stock

    2010-02-08

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Parts, 1, 31, and 301 [REG-101896-09] RIN 1545-Bl66 Basis Reporting by Securities Brokers and Basis Determination for Stock Correction In proposed rule document E9-29855 beginning on page 67010 in the issue of Thursday, December 17, 2009, make...

  14. SENTINEL trademark technical basis report for Limerick. Final report

    Burns, E.T.; Lee, L.K.; Mitman, J.T.; Vanover, D.E.; Wilson, D.K.

    1997-12-01

    PECO Energy in cooperation with the Electric Power Research Institute (EPRI) installed the SENTINEL trademark software at its Limerick Generating Station. This software incorporates models of the safety and support systems which are used to display the defense in depth present in the plant and a quantitative assessment of the plant risks during proposed on-line maintenance. During the past year, PECO Energy personnel have used this display to evaluate the safety of proposed on-line maintenance schedules. The report describes the motivation for and the development of the SENTINEL software. It describes the generation of Safety Function Assessment Trees and Plant Transient Assessment Trees and their use in evaluating the level of defense-in-depth of key plant safety functions and the susceptibility of the plant to critical transient events. Their results are displayed by color indicators ranging from green, through yellow and orange to red to show increasingly hazardous conditions. The report describes the use of the Limerick Probabilistic Safety Assessment within the SENTINEL code to calculate an instantaneous core damage frequency and the criteria by which this frequency is translated to a color indicator. Finally, the report describes the Performance Criteria Assessment which tracks and trends system/train unavailability to document conformance to the requirements of the Maintenance Rule

  15. SENTINEL trademark technical basis report for Peach Bottom. Final report

    1998-04-01

    PECO Energy in cooperation with the Electric Power Research Institute (EPRI) installed the SENTINEL trademark software at its Peach Bottom Atomic Power Station (PBAPS). This software incorporates models of the safety and support systems which are used to display the defense in depth present in the plant and a quantitative assessment of the plant risks during proposed on-line maintenance. During the past nine months, PECO Energy personnel have used this display to evaluate the safety of proposed on-line maintenance schedules. The report describes the motivation for and the development of the SENTINEL software. It describes the generation of Safety Function Assessment Trees and Plant Transient Assessment Trees and their use in evaluating the level of defense-in-depth of key plant safety functions and the susceptibility of the plant to critical transient events. Their results are displayed by color indicators ranging from green, through yellow and orange, to red to show increasingly hazardous conditions. The report describes the use of the PBAPS Probabilistic Safety Assessment within the SENTINEL code to calculate an instantaneous core damage frequency and the criteria by which this frequency is translated to a color indicator

  16. Development of the Conceptual Basis for Enterprise Integrated Reporting

    Budko Oksana V.

    2017-09-01

    Full Text Available The aim of the article is to study the conceptual basis for integrated reporting in terms of its drafting principles, taking into account the need to satisfy the information requests of interested parties regarding the company’s value in the long run and the level of implementation of its sustainable development strategy. As a result of the study, the goals of integrated reporting are defined, with consideration for the sustainable development strategy chosen by the company, which can be achieved by accomplishing tasks, among which a special role is played by the support of integrated thinking at making decisions about creating value in the short, medium and long term. It is indicated that the basis for preparing integrated reports is the use of clearly defined principles, both in respect to their list and content. The composition of the principles specified in the International Integrated Reporting Framework (IIRF is analyzed, and it is found that some of them require clarifying (strategic focus and future orientation, or defining as part of quality characteristics or requirements (reliability, comparability, interaction with stakeholders. The list of leading (basic principles is supplemented with additional principles (synergism, neutrality, efficiency, validity, logicality, the observance of which will ensure an increase in the value and content of integrated reporting. A prospect for further research is analysis of the defined by ISIR integrated reporting structure that requires improvement in part of the list of sections and their content, and will take into account the need to provide information in the interdependence of factors of economic, environmental and social influence and financial indicators in making decisions by stakeholders.

  17. Design basis document open-item resolution and reportability

    Gambhir, S.K.; Livingston, B.R.; Purcell, J.J.; Erickson, E.A.

    1989-01-01

    In the process of reconstituting the design bases for older nuclear power plants, information or references may not be available to fully define the design requirements or to document and verify the adequacy of the design. Also, information that is in conflict with other data is identified. The missing and conflicting information must be reconstituted in order to adequately document the design bases of the plant. For these operating facilities, the identification, tracking, and resolution of missing or conflicting information is very important when the reporting requirements stipulated by 10CFR21, 10CFR50.72, and 10CFR50.73 are considered. Additionally, controlled documentation (calculations, drawings, etc.) used to develop the design basis documents may contain conflicting data. In some cases, conflicts between the as-built design and licensing or design basis requirements established in specific commitments to the U.S. Nuclear Regulatory Commission may be identified. Furthermore, concerns regarding the adequacy of safety-related systems or components to perform their required function may be identified that would warrant prompt action by the licensee. The approach discussed in this paper was used by Omaha Public Power District for the ongoing design basis reconstitution effort at the Fort Calhoun nuclear plant

  18. 78 FR 23116 - Basis Reporting by Securities Brokers and Basis Determination for Debt Instruments and Options...

    2013-04-18

    ... in the burden on Form 1099-B, ``Proceeds from Broker and Barter Exchange Transactions,'' when revised... not provide them sufficient time to build and test the systems required to implement the reporting... to allow brokers to test and refine their reporting systems. In response to these comments, as was...

  19. Preventive maintenance basis: Volume 31 -- Relays -- timing. Final report

    Worledge, D.; Hinchcliffe, G.

    1998-07-01

    US nuclear power plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This document provides a program of preventive maintenance tasks suitable for application to timing relays. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used in conjunction with material from other sources, to develop a complete PM program or to improve an existing program

  20. Preventive maintenance basis: Volume 30 -- Relays -- control. Final report

    Worledge, D.; Hinchcliffe, G.

    1998-07-01

    US nuclear power plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This document provides a program of preventive maintenance tasks suitable for application to control relays. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used in conjunction with material from other sources, to develop a complete PM program or to improve an existing program

  1. Exploratory Shaft Seismic Design Basis Working Group report

    Subramanian, C.V.; King, J.L.; Perkins, D.M.; Mudd, R.W.; Richardson, A.M.; Calovini, J.C.; Van Eeckhout, E.; Emerson, D.O.

    1990-08-01

    This report was prepared for the Yucca Mountain Project (YMP), which is managed by the US Department of Energy. The participants in the YMP are investigating the suitability of a site at Yucca Mountain, Nevada, for construction of a repository for high-level radioactive waste. An exploratory shaft facility (ESF) will be constructed to permit site characterization. The major components of the ESF are two shafts that will be used to provide access to the underground test areas for men, utilities, and ventilation. If a repository is constructed at the site, the exploratory shafts will be converted for use as intake ventilation shafts. In the context of both underground nuclear explosions (conducted at the nearby Nevada Test Site) and earthquakes, the report contains discussions of faulting potential at the site, control motions at depth, material properties of the different rock layers relevant to seismic design, the strain tensor for each of the waveforms along the shaft liners, and the method for combining the different strain components along the shaft liners. The report also describes analytic methods, assumptions used to ensure conservatism, and uncertainties in the data. The analyses show that none of the shafts' structures, systems, or components are important to public radiological safety; therefore, the shafts need only be designed to ensure worker safety, and the report recommends seismic design parameters appropriate for this purpose. 31 refs., 5 figs., 6 tabs

  2. Low level mixed waste thermal treatment technical basis report

    Place, B.G.

    1994-12-01

    Detailed characterization of the existing and projected Hanford Site Radioactive Mixed Waste (RMW) inventory was initiated in 1993 (Place 1993). This report presents an analysis of the existing and projected RMW inventory. The subject characterization effort continues to be in support of the following engineering activities related to thermal treatment of Hanford Site RMW: (1) Contracting for commercial thermal treatment; (2) Installation and operation of an onsite thermal treatment facility (Project W-242); (3) Treatment at another Department of Energy (DOE) site. The collation of this characterization information (data) has emphasized the establishment of a common data base for the entire existing RMW inventory so that the specification of feed streams destined for different treatment facilities can be coordinated.

  3. Low level mixed waste thermal treatment technical basis report

    Place, B.G.

    1994-12-01

    Detailed characterization of the existing and projected Hanford Site Radioactive Mixed Waste (RMW) inventory was initiated in 1993 (Place 1993). This report presents an analysis of the existing and projected RMW inventory. The subject characterization effort continues to be in support of the following engineering activities related to thermal treatment of Hanford Site RMW: (1) Contracting for commercial thermal treatment; (2) Installation and operation of an onsite thermal treatment facility (Project W-242); (3) Treatment at another Department of Energy (DOE) site. The collation of this characterization information (data) has emphasized the establishment of a common data base for the entire existing RMW inventory so that the specification of feed streams destined for different treatment facilities can be coordinated

  4. Preventive maintenance basis: Volume 15 -- Rotary screw air compressors. Final report

    Worledge, D.; Hinchcliffe, G.

    1997-07-01

    US nuclear plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This report provides an overview of the PM Basis project and describes use of the PM Basis database. Volume 15 of the report provides a program of PM tasks suitable for application to rotary screw air compressors in nuclear power plants. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used, in conjunction with material from other sources, to develop a complete PM program or to improve an existing program. Users of this information will be utility managers, supervisors, craft technicians, and training instructors responsible for developing, optimizing, or fine-tuning PM programs

  5. Preventive maintenance basis: Volume 16 -- Power operated relief valves, solenoid actuated. Final report

    Worledge, D.; Hinchcliffe, G.

    1997-07-01

    US nuclear plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This report provides an overview of the PM Basis project and describes use of the PM Basis database. This volume 16 of the report provides a program of PM tasks suitable for application to power operated relief valves (PORV's) that are solenoid actuated. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used, in conjunction with material from other sources, to develop a complete PM program or to improve an existing program. Users of this information will be utility managers, supervisors, craft technicians, and training instructors responsible for developing, optimizing, or fine-tuning PM programs

  6. Preventive maintenance basis: Volume 21 -- HVAC, air handling equipment. Final report

    Worledge, D.; Hinchcliffe, G.

    1997-12-01

    US nuclear plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This report provides an overview of the PM Basis project and describes use of the PM Basis database. Volume 21 of the report provides a program of PM tasks suitable for application to HVAC-Air Handling Equipment. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used, in conjunction with material from other sources, to develop a complete PM program or to improve an existing program. Users of this information will be utility managers, supervisors, craft technicians, and training instructors responsible for developing, optimizing, or fine-tuning PM programs

  7. Preliminary tank characterization report for single-shell tank 241-TX-101: best-basis inventory

    Kupfer, M.J.

    1997-01-01

    This document is a preliminary Tank Characterization Report (TCR). It only contains the current best-basis inventory (Appendix D) for single-shell tank 241-TX-101. No TCRs have been previously issued for this tank, and current core sample analyses are not available. The best-basis inventory, therefore, is based on an engineering assessment of waste type, process flowsheet data, early sample data, and/or other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available

  8. Preliminary tank characterization report for single-shell tank 241-TY-102: best-basis inventory

    Place, D.E.

    1997-01-01

    This document is a preliminary Tank Characterization Report (TCR). It only contains the current best-basis inventory (Appendix D) for single-shell tank 241-TY-102. No TCRs have been previously issued for this tank, and current core sample analyses are not available. The best-basis inventory, therefore, is based on an engineering assessment of waste type, process flowsheet data, early sample data, and/or other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available

  9. Preliminary tank characterization report for single-shell tank 241-TX-113: best-basis inventory

    Place, D.E.

    1997-01-01

    This document is a preliminary Tank Characterization Report (TCR). It only contains the current best-basis inventory (Appendix D) for single-shell tank 241-TX-113. No TCRs have been previously issued for this tank, and current core sample analyses are not available. The best-basis inventory, therefore, is based on an engineering assessment of waste type, process flowsheet data, early sample data, and/or other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available

  10. Preventive maintenance basis: Volume 1 -- Air-operated valves. Final report

    Worledge, D.; Hinchcliffe, G.

    1997-07-01

    US nuclear plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This report provides an overview of the PM Basis project and describes use of the PM Basis database. This document provides a program of PM tasks suitable for application to Air Operated Valves (AOV's) in nuclear power plants. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used, in conjunction with material from other sources, to develop a complete PM program or to improve an existing program. Users of this information will be utility managers, supervisors, craft technicians, and training instructors responsible for developing, optimizing, or fine-tuning PM programs

  11. Licensing topical report: application of probabilistic risk assessment in the selection of design basis accidents

    Houghton, W.J.

    1980-06-01

    A probabilistic risk assessment (PRA) approach is proposed to be used to scrutinize selection of accident sequences. A technique is described in this Licensing Topical Report to identify candidates for Design Basis Accidents (DBAs) utilizing the risk assessment results. As a part of this technique, it is proposed that events with frequencies below a specified limit would not be candidates. The use of the methodology described is supplementary to the traditional, deterministic approach and may result, in some cases, in the selection of multiple failure sequences as DBAs; it may also provide a basis for not considering some traditionally postulated events as being DBAs. A process is then described for selecting a list of DBAs based on the candidates from PRA as supplementary to knowledge and judgments from past licensing practice. These DBAs would be the events considered in Chapter 15 of Safety Analysis Reports of high-temperature gas-cooled reactors

  12. [Preparation and assignment of medical reports: basis for settlement of compensation claims].

    Thomann, K D

    2011-03-01

    Medical reporting represents an essential element in the settlement of personal claims. Moreover, the report prepares the basis for determing the compensation which is appropriate to the injury. The practice of instructing the expert medical assessor to obtain the medical documents required has proved a failure and causes delays in completion of the report. The doctor who is the expert medical assessor is often unsuccessful in obtaining these vital documents. In doubtful cases the expert will deliver his report without access to the vital documents. Incomplete reports affect the settlement adversely and promote unnecessary legal disputes. Many errors can be avoided if the officials of the relevant insurance company prepare the report assignment carefully. Such preparation includes clarification of the accident circumstances, requests for copies of the primary diagnosis and requests for hospital and medical reports, including full details of surgery carried out. Printouts of the daily reports by the doctors involved are also required. Of course these doctors must be released from the obligation to treat medical records confidentially. Furthermore, if the original documents are used, results of the injury which may seem insignificant will not be overlooked. The report assignment and primary medical documents should be sent to the medical assessor at the same time. The report assignment contains a detailed questionnaire which takes into account the particular aspects of the individual claim.

  13. Breckinridge Project, initial effort. Report XI, Volume V. Critical review of the design basis. [Critical review

    None

    1982-01-01

    Report XI, Technical Audit, is a compendium of research material used during the Initial Effort in making engineering comparisons and decisions. Volumes 4 and 5 of Report XI present those studies which provide a Critical Review of the Design Basis. The Critical Review Report, prepared by Intercontinental Econergy Associates, Inc., summarizes findings from an extensive review of the data base for the H-Coal process design. Volume 4 presents this review and assessment, and includes supporting material; specifically, Design Data Tabulation (Appendix A), Process Flow Sheets (Appendix B), and References (Appendix C). Volume 5 is a continuation of the references of Appendix C. Studies of a proprietary nature are noted and referenced, but are not included in these volumes. They are included in the Limited Access versions of these reports and may be reviewed by properly cleared personnel in the offices of Ashland Synthetic Fuels, Inc.

  14. Analysis and evaluation of the ASTEC model basis. Relevant experiments. Technical report

    Koppers, V.; Koch, M.K.

    2015-12-01

    The present report is a Technical Report within the research project ''ASMO'', funded by the German Federal Ministry of Economics and Technology (BMWi 1501433) and projected at the Reactor Simulation and Safety Group, Chair of Energy Systems and Energy Economics (LEE) at the Ruhr-Universitaet Bochum (RUB). The project deals with the analysis of the model basis of the Accident Source Term Evaluation Code (ASTEC). This report focuses on the containment part of ASTEC (CPA) and presents the simulation results of the experiment TH20.7. The experimental series TH20 was performed in the test vessel THAI (Thermal-hydraulics, Aerosols, Iodine) to investigate the erosion of a helium layer by a blower generated air jet. Helium is used as a substitute for hydrogen. In the experiment TH20.7 a light-gas layer is established and eroded by a momentum driven jet. The simulation of momentum driven jets is challenging for CPA because there is no model to simulate the kinetic momentum transfer. Subject of this report is the analysis of the capability of the code with the current model basis to model momentum driven phenomena. The jet is modelled using virtual ventilation systems, so called FAN-Systems. The FAN-Systems are adapted to the erosion velocity. The simulation results are compared to the experimental results and a basic calculation using FAN-Systems without any adjustments. For further improvement, different variation calculations are performed. At first, the vertical nodalization is refined. Subsequently, the resistance coefficients are adjusted to support the jet flow pattern and the number of the FAN-Systems is reduced. The analysis shows that the simulation of a momentum driven light-gas layer erosion is possible using adjusted FAN-Systems. A fine selected vertical nodalization and adaption of the resistance coefficients improves the simulation results.

  15. THEORETICAL BASIS FOR RESEARCH OF QUALITY OF ACCOUNTING INSTITUTIONS IN THE ACCOUNTING (FINANCIAL REPORTS

    Horbach Tatiana

    2018-01-01

    Full Text Available Introduction. The main goal of changing accounting systems in different countries today is improving the quality of accounting information and achieving a high level of user confidence in accounting (financial reporting. However, the diversity of user needs is not the main reason why the problem of improving the quality of accounting and reporting data remains relevant. Purpose. Development of separate provisions of the theory of accounting in terms of ensuring high quality of accounting (financial reporting and development of practical recommendations for the assessment of the quality of the process of formation of accounting (financial reporting. Results. The article discloses the features of informational content of accounting (financial reporting in modern conditions. The comprehensive model of accounting information specifies the substantive content of the concept, the methodical approach to the assessment of the quality of accounting (financial reporting, taking into account the peculiarities of the organizational design of the quality management process for reporting and the peculiarities of the operation of the accounting and analytical system of the enterprise. The main identified problem areas are the formation of qualitative accounting (financial reporting. It is shown that the qualitative characteristics of accounting information and accounting (financial reporting can not be only within the framework of the work of the accounting system, but also must be lead by a set of factors that determine the end-user characteristics of accounting information. Conclusions. The internal content and essence of the abstract category “quality” are considered in detail, and it is demonstrated, as in the concretization of the subject, the conceptual design “quality of accounting (financial reporting” can be introduced. On the basis of the studies of Ukrainian and foreign scholars, eight areas are identified, which identify the main issues of

  16. Correlation Model between Economic Development and Environmental Performance on the Basis of Non-Financial Reporting

    Vladimir Dmitrievich Bogdanov

    2016-03-01

    Full Text Available The most common international standards for the non-financial reporting are reviewed. The Global Reporting Initiative (GRI is determined as an optimal standard of sustainability reporting for the use in the Russian conditions. The environmental component of guidance on the compilation of G4 non-financial reporting of GRI standard is analyzed, the contribution of each aspect in terms of the overall picture of sustainability is determined. The progress of economic science has outlined the importance of incorporating natural components. Moreover, the value of biological resources would be increased through time, and therefore, the economic development of the company cannot be in isolation. To determine the degree of harmony between the economic development and ecological condition of the territory where the company carries out the economic activities, the application of new approaches and methods is necessary. Based on the statistical methods, a correlation model between economic development and environmental performance is developed to identify their relationship on the basis of non-financial reporting. The developed model of correlation can be used by a wide range of oil and gas companies and its general principles by the companies of different industries. The results may be of interest to stakeholders, also, it can be used for administrative purposes, to serve as a platform for forecasting and adoption of administrative decisions to achieve harmony between economic development and environmental performance. The model of correlation has been tested for the data of non-financial reporting of the Russian largest oil and gas company JSC “Surgutneftegas”. The testing has shown a positive relationship between the two systems of the company’s sustainable development: economy and ecology. This obtained result demonstrates a high level of social responsibility of the company in terms of environmental protection. A further study in this field can

  17. Grid fault and design-basis for wind turbines - Final report

    Hansen, Anca Daniela; Cutululis, Nicolaos Antonio; Markou, Helen

    , have been performed and compared for two cases, i.e. one when the turbine is immediately disconnected from the grid when a grid fault occurs and one when the turbine is equipped with a fault ride-through controller and therefore it is able to remain connected to the grid during the grid fault......This is the final report of a Danish research project “Grid fault and design-basis for wind turbines”. The objective of this project has been to assess and analyze the consequences of the new grid connection requirements for the fatigue and ultimate structural loads of wind turbines....... The fulfillment of the grid connection requirements poses challenges for the design of both the electrical system and the mechanical structure of wind turbines. The development of wind turbine models and novel control strategies to fulfill the TSO’s requirements are of vital importance in this design. Dynamic...

  18. Analysis and evaluation of the ASTEC model basis on plant simulations. 2. Technical report

    Koppers, Vera; Braehler, Thimo; Koch, Marco K.

    2015-06-01

    The present report is the 2 nd Technical Report of the research project ''Analysis and Evaluation of the ASTEC model basis'' funded by the Federal Ministry for Economic Affairs and Energy (BMWi 1501433) and conducted at the Reactor Simulation and Safety Group, Chair of Energy Systems and Energy Economics (LEE) at Ruhr-Universitaet Bochum. Within this report, the quality of a nuclear power plant simulation with ASTEC is investigated. Different parameters are varied to analyze the simulation stability within the dataset, which describes a generic German Konvoi power plant and is deposit in the program set of ASTEC. Firstly, plant specifications in the data set are checked for plausibility. In addition, the compliance of the data set with the nodalization rules is verified. After that, the stationary phase, in which no accident is calculated, is analyzed and parametric studies are performed in the transient phase, focusing on the primary and secondary circuit as well as on the containment behavior. The performed calculations focusing the primary and secondary circuit indicate a high dependency of the simulation results on the user's input in the data set. There are significant deviations between each simulations results, for example in the different calculated point of time of the reactor pressure vessel failure. Already changes in the stationary phase cause a significantly earlier reactor pressure vessel failure compared to the simulation with the original data. Beyond that, the location of the leakage of the reactor pressure vessel lower head varied and therefore cannot be clearly determined, although there have been no changes by the user on the accident course. A reliable indication of the plant behavior under severe accident conditions is therefore difficult using ASTEC. The results of the parametric studies within the Containment show the same significant influence of certain parameter changes on the simulation results. By using the

  19. Making the decision-making basis for nuclear waste management transparent - A pre-study report

    Andersson, Kjell

    2007-04-01

    The pre-study report proposes that KASAM (Swedish National Council for Nuclear Waste, an independent committee attached to the Swedish Ministry of Environment) uses the RISCOM Model to support the transparency programme. Recurrent elements in the programme would then be: A clear description of background for the issue being addressed; Knowledge building activities; A hearing where the KASAM committee members and staff stretch the stakeholders. The transparency programme can combine the RISCOM Model with other approaches to citizen participation at occasions when this is deemed suitable. For example, focus groups, other forms of working groups and consensus conferences could be organized and linked to a 'RISCOM hearing'. Therefore, the pre-study report contains an overview section about methods for public participation. At this stage of the Swedish programme for nuclear waste management it is believed that KASAM can provide an arena for transparency which other stakeholders can trust not having hidden agendas or vested interested in the results. During the pre-study a number of stakeholders were approached to give their views about the format and contents of the transparency programme. The consultations showed great expectations on the programme and a large number of issues were raised that could be included in transparency creating activities. A typical activity will be relatively resource demanding, especially with respect to the time available for key stakeholders. Therefore, issues to be addressed must be critically prioritised. The pre-study report contains nine issues proposed for special efforts by KASAM: Deep bore holes as a possible alternative method for final disposal; Citizen participation and democracy; The roles of responsible authorities; Decommissioning of nuclear reactors; Site selection - on what basis?; Socioeconomic issues; Local environmental issues and regional environmental goals; Long term storage of spent nuclear fuel; Critical assumptions

  20. Preventive maintenance basis: Volume 10 -- High voltage electric motors (5 kV and greater). Final report

    Worledge, D.; Hinchcliffe, G.

    1997-07-01

    US nuclear plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This report provides an overview of the PM Basis project and describes use of the PM Basis database. Volume 10 of the report provides a program of PM tasks suitable for application to high voltage (5kV and greater) electric motors in nuclear power plants. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used, in conjunction with material from other sources, to develop a complete PM program or to improve an existing program. Users of this information will be utility managers, supervisors, craft technicians, and training instructors responsible for developing, optimizing, or fine-tuning PM programs. Reactor Coolant Pumps motors (RCP's) are not excluded from this report in so far as good PM practices for motors of the appropriate class are concerned. However, the special auxiliary equipment normally associated with RCP's has not been included. Consequently, this report does not provide a complete PM program for RCP's. Industry and vendor programs for RCP's should be consulted for complete definition of RCP motor PM programs

  1. Grid fault and design-basis for wind turbines. Final report

    Hansen, A.D.; Cutululis, N.A.; Markou, H.; Soerensen, Poul; Iov, F.

    2010-01-15

    This is the final report of a Danish research project 'Grid fault and design-basis for wind turbines'. The objective of this project has been to assess and analyze the consequences of the new grid connection requirements for the fatigue and ultimate structural loads of wind turbines. The fulfillment of the grid connection requirements poses challenges for the design of both the electrical system and the mechanical structure of wind turbines. The development of wind turbine models and novel control strategies to fulfill the TSO's requirements are of vital importance in this design. Dynamic models and different fault ride-through control strategies have been developed and assessed in this project for three different wind turbine concepts (active stall wind turbine, variable speed doublyfed induction generator wind turbine, variable speed multipole permanent magnet wind turbine). A computer approach for the quantification of the wind turbines structural loads caused by the fault ride-through grid requirement, has been proposed and exemplified for the case of an active stall wind turbine. This approach relies on the combination of knowledge from complimentary simulation tools, which have expertise in different specialized design areas for wind turbines. In order to quantify the impact of the grid faults and grid requirements fulfillment on wind turbines structural loads and thus on their lifetime, a rainflow and a statistical analysis for fatigue and ultimate structural loads, respectively, have been performed and compared for two cases, i.e. one when the turbine is immediately disconnected from the grid when a grid fault occurs and one when the turbine is equipped with a fault ride-through controller and therefore it is able to remain connected to the grid during the grid fault. Different storm control strategies, that enable variable speed wind turbines to produce power at wind speeds higher than 25m/s and up to 50m/s without substantially increasing

  2. Preliminary tank characterization report for single-shell tank 241-TX-103: Best-basis inventory

    Hendrickson, D.W.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-103 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task. The best-basis inventory is based on an engineering assessment of waste type, process flowsheet data, early sample data, and/or other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes (Kupfer et al. 1997) describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available

  3. Preventive maintenance basis: Volume 37 -- Main turbine EHC hydraulics. Final report

    Worledge, D.; Hinchcliffe, G.

    1998-11-01

    US nuclear power plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This document provides a program of preventive maintenance tasks suitable for application to the main turbine EHC hydraulic fluid and associated components. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used in conjunction with material from other sources, to develop a complete PM program or to improve an existing program

  4. Preliminary tank characterization report for single-shell tank 241-TX-111: Best-basis inventory

    Place, D.E.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-111 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task. The best-basis inventory is based on an engineering assessment of waste type, process flowsheet data, early sample data, and/or other available information. The Standard Inventories of Chemicals and Radionuclides in Hanford Site Tank Wastes (Kupfer et al. 1997) describes standard methodology used to derive the tank-by-tank best-basis inventories. This preliminary TCR will be updated using this same methodology when additional data on tank contents become available

  5. Preventive maintenance basis: Volume 19 -- HVAC -- chillers and compressors. Final report

    Worledge, D.; Hinchcliffe, G.

    1997-12-01

    US nuclear power plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This document provides a program of preventive maintenance tasks suitable for application to HVAC -- Chillers and Compressors. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used in conjunction with material from other sources, to develop a complete PM program or to improve an existing program

  6. 26 CFR 13.11 - Revocation of election to report income on the installment basis.

    2010-04-01

    ... to the provisions of section 453(c)(1) (relating to change from accrual to installment basis), may... income on the amended returns described in this section, the taxpayer shall use the accrual method of accounting. [T.D. 7044, 35 FR 8823, June 6, 1970] ...

  7. Preliminary tank characterization report for single-shell tank 241-TX-110: Best-basis inventory

    Place, D.E.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-110 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  8. Preliminary tank characterization report for single-shell tank 241-BX-102: best-basis inventory

    Kupfer, M.J.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-BX-102 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  9. Prelimainary tank characterization report for single-shell tank 241-TY-103 : Best-Basis inventory

    Hendrickson, D.W.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241'-TY-103 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  10. Preliminary tank characterization report for single-shell tank 241-U-103: best-basis inventory

    Kupfer, M.J.; Stout, R.E.; Winward, R.T.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-U-103 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  11. Preliminary tank characterization report for single-shell tank 241-BY-101: best-basis inventory

    Kupfer, M.J.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-BY-101 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  12. Preliminary tank characterization report for single-shell tank 241-SX-112: Best-basis inventory

    Kupfer, M.J.; Schulz, W.W.; Winward, R.T.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-SX-112 was performed, and a best-basis, inventory was established. This work follows the methodology that was established by the standard inventory task

  13. Preliminary tank characterization report for single-shell tank 241-TX-116: best-basis inventory

    Place, D.E.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TX-116 was performed, and a bost-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  14. Preliminary tank characterization report for single-shell tank 241-TY-101: best-basis inventory

    Lambert, S.L.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-TY-101 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  15. Preliminary tank characterization report for single-shell tank 241-SX-107: Best-basis inventory

    Kupfer, M.J.; Schulz, W.W.; Jones, T.E.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-SX-107 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  16. Preliminary tank characterization report for single-shell tank 241-BX-111: best-basis inventory

    Kupfer, M.J.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort, an evaluation of available information for single-shell tank 241-BX-111 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  17. High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Main report, Volume 2

    Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B.

    1995-06-01

    The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer e following software development and assurance activities: Requirements specification; design; coding; verification and validation, inclukding static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire ran e identification, categorization and prioritization of technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary includes an overview of the framwork and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; this document, Volume 2, is the main report

  18. High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Main report, Volume 2

    Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B. [Mitre Corp., McLean, VA (United States)

    1995-06-01

    The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer e following software development and assurance activities: Requirements specification; design; coding; verification and validation, inclukding static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire ran e identification, categorization and prioritization of technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary includes an overview of the framwork and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; this document, Volume 2, is the main report.

  19. Research and experience report 2012. Developments in the technical and legal basis of nuclear oversight

    2013-04-01

    The Swiss Federal Nuclear Safety Inspectorate (ENSI) acts upon the basis of the latest developments in science and technology. ENSI supports and coordinates safety research, the results of which influence directly its Guidelines, individual decisions and resources. Research projects also serve training purposes and maintain competence within ENSI and its experts. The research in fuels and materials covers the reactor core and the graded approach to barriers used for the confinement of radioactive materials. Based on test results from accidents involving a loss of coolant ENSI instructed the operators of Swiss nuclear power plants to review whether they were relevant to their own facilities. Ageing mechanisms affecting structural materials are crucial to the long-term operation of nuclear power plants. Specialised thematic databases are being created in order to facilitate a systematic analysis of relevant operating experience from numerous countries. In addition to damage that may result from events within nuclear power plants, the safety analyses also reflect external events. ENSI supports international projects conducting complex experiments and simulations of aircraft accidents and earthquakes. It is involved in some projects relating to flood risks. The effect of operator behaviour on accidents in nuclear power plants is the focus point of research into human factors which identifies and analyses certain operator errors influencing negatively the course of an accident. Proposals to improve accident procedures were developed. This research area also focuses on the influence of the control room layout on the performance of operating staff. System behaviour and accident sequences in nuclear power plants are analysed in conditions ranging from normal operations through to accidents resulting in core melt-down. The results are used for the quantitative evaluation of the plant risk in probabilistic safety analyses. Applied research in radiological protection ranges

  20. Preliminary tank characterization report for single-shell tank 241-B-105: best-basis inventory

    Higley, B.A.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the at sign various waste management activities. As part of this effort, an evaluation of available information for singlb-shell tank 241-B-105 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  1. Preliminary tank characterization report for single-shell tank 241-SX-111: Best-basis inventory

    Kupfer, M.J.; Schulz, W.W.; Winward, R.T.

    1997-01-01

    An effort is underway to provide waste inventory estimates that will serve as standard characterization source terms for the various waste management activities. As part of this effort,.an evaluation of available information for single-shell tank 241-SX-111 was performed, and a best-basis inventory was established. This work follows the methodology that was established by the standard inventory task

  2. Survey report of site selection process on the basis of local partnerships. Slovenia and Belgium

    Yoshioka, Tatsuji; Nakata, Hisakazu; Kanzaki, Noriko; Osawa, Hideaki; Hayakawa, Tsuyoshi

    2014-01-01

    Local partnership approach to achieve stakeholder consensus on low-level waste disposal, with particular focus on the siting of repositories are adopted in Europe. Especially in Belgium and Slovenia, final repository site had been decided in each country. The authors investigate on these two cases on the basis of interviews with implementing organizations for final disposal, representatives of local partnerships and citizens concerned so that the problem of introducing a local partnership in Japan can be examined. Its results are used as a reference for studying measures to determine the radioactive final repository site in Japan. (author)

  3. Biochemical basis of drought tolerance in hybrid Populus grown under field production conditions. CRADA final report

    Tschaplinski, T.J.; Tuskan, G.A. [Oak Ridge National Lab., TN (United States); Wierman, C. [Boise Cascade Corp., Wallula, WA (United States)

    1997-04-01

    The purpose of this cooperative effort was to assess the use of osmotically active compounds as molecular selection criteria for drought tolerance in Populus in a large-scale field trial. It is known that some plant species, and individuals within a plant species, can tolerate increasing stress associated with reduced moisture availability by accumulating solutes. The biochemical matrix of such metabolites varies among species and among individuals. The ability of Populus clones to tolerate drought has equal value to other fiber producers, i.e., the wood products industry, where irrigation is used in combination with other cultural treatments to obtain high dry weight yields. The research initially involved an assessment of drought stress under field conditions and characterization of changes in osmotic constitution among the seven clones across the six moisture levels. The near-term goal was to provide a mechanistic basis for clonal differences in productivity under various irrigation treatments over time.

  4. UNIFICATION OF ACCOUNTING PROCEDURES AS A BASIS FOR FORMATION OF CONSOLIDATED SEGMENTARY REPORTING OF AGROHOLDING

    Aleksandra V. Glushchenko

    2018-01-01

    Full Text Available The most important area of sustainable development of agricultural production is the development of agro-industrial integration, which is the economic, informational, organizational and technological association of the enterprises of agriculture with the processing, transportation, servicing and other entities. Complex multi-level management system, diversified operations, the wide geography of markets, territorial fragmentation of integrated agroformations’ participants demand higher information capacity of accounting and reporting, and the formation of discrete and relevant information on the separate components (segments activities of agricultural holdings. Segments of agrostructure activity often include a plurality of interconnected companies that are legally independent entities, that makes it necessary to aggregate the registration information in the whole group of economic entities forming segment presented in the accounting and reporting as a single economic unit. In order to solve this problem, we developed a method of forming the consolidated information by segment feature based on a set of procedures for the four interrelated steps: 1 preparation – definition of reportable segments in accordance with the criteria of segmentation, development of uniform accounting policies for segmental reporting purposes, indicators and the format of segmental reporting; 2 basic – specification of parameters and format worksheets, tables and transformational forms of reporting, collecting the individual statements of the segments, the transformation of the individual reporting data from the analytical forms of the participants segment, followed by elimination of intergroups turnovers; 3 consolidation – the formation of summary reports and correction tables, consolidated statements, transfer of data from the consolidated statements to the form of segmental reporting; 4 analysis – verification of compliance with the principle of consistency

  5. Technical basis for the ITER detailed design report, cost review and safety analysis (DDR)

    1997-01-01

    The ITER Detailed Design Report (DDR), Cost Review and Safety Analysis is the 3rd major milestone representing the progress made in the ITER Engineering Design Activities. With the approval of the Interim Design Report (IDR), it has been possible to freeze the main concepts and system approaches for ITER and to develop the design in more detail for the individual components and sub-systems. This report, although designed to be fully understandable as a separate document, focusses particularly on the main changes since the IDR

  6. Technical basis for the ITER detailed design report, cost review and safety analysis (DDR)

    NONE

    1997-12-01

    The ITER Detailed Design Report (DDR), Cost Review and Safety Analysis is the 3rd major milestone representing the progress made in the ITER Engineering Design Activities. With the approval of the Interim Design Report (IDR), it has been possible to freeze the main concepts and system approaches for ITER and to develop the design in more detail for the individual components and sub-systems. This report, although designed to be fully understandable as a separate document, focusses particularly on the main changes since the IDR. Refs, figs, tabs

  7. THEORETICAL BASIS FOR RESEARCH OF QUALITY OF ACCOUNTING INSTITUTIONS IN THE ACCOUNTING (FINANCIAL) REPORTS

    Horbach Tatiana; Drozd Serhiy; Fedoryk Pavlo

    2018-01-01

    Introduction. The main goal of changing accounting systems in different countries today is improving the quality of accounting information and achieving a high level of user confidence in accounting (financial) reporting. However, the diversity of user needs is not the main reason why the problem of improving the quality of accounting and reporting data remains relevant. Purpose. Development of separate provisions of the theory of accounting in terms of ensuring high quality of accounting...

  8. Research and experience report 2010 - Developments in the technical and legal basis of nuclear oversight

    2011-04-01

    This comprehensive annual report presents a review of the activities carried out by the Swiss Federal Nuclear Safety Inspectorate (ENSI) in the year 2010. The inspectorate's fields of activity - fuels and materials, significant internal and external events and occurrences, human factors, system behaviour and accident sequences, radiological protection and waste disposal - are reviewed. Information on incidents in Swiss nuclear facilities are reviewed in the ENSI Surveillance Report. The Research and Experience Report also provides information on a selection of particularly instructive incidents in nuclear facilities outside Switzerland. Incidents are analysed with a view to identifying any potential relevance to Swiss nuclear facilities. International co-operation is mentioned and current changes and developments related to plant surveillance are noted. Organisational aspects are discussed and various guidelines and directives are presented and discussed

  9. A lack of standardization: the basis for the ethical issues surrounding quality and performance reports.

    Suchy, Kirsten

    2010-01-01

    Consumers in the United States are taking advantage of the proliferation of publicly available, internet-based performance reports and quality appraisals of health plans, healthcare organizations, hospitals, and physicians to aid in their healthcare decision making. However, these appraisal practices have given rise to controversy and debate over certain distinctive ethical issues. This article advocates a standardized ethical framework to guide current and future development and implementation of performance reports. This framework, which would resolve a number of the major issues, includes the following ethical principles to guide the practice of public reporting on the Internet and facilitate enhanced quality improvement in the healthcare industry: legitimacy, data integrity and quality, transparency, informed understanding, equity, privacy and confidentiality, collaboration, accountability, and evaluation and continuous improvement.

  10. Technical basis for the ITER final design report, cost review and safety analysis (FDR)

    NONE

    1998-12-01

    The ITER final design report, cost review and safety analysis (FDR) is the 4th major milestone, representing the progress made in the ITER Engineering Design Activities. With the approval of the Detailed Design Report (DDR), the design work was concentrated on the requirements of operation, with only relatively minor changes to design concepts of major components. The FDR is the culmination of almost 6 years collaborative design and supporting technical work by the ITER Joint Central Team and Home Teams under the terms of the ITER EDA Agreement. Refs, figs, tabs

  11. Technical basis for the ITER final design report, cost review and safety analysis (FDR)

    1998-01-01

    The ITER final design report, cost review and safety analysis (FDR) is the 4th major milestone, representing the progress made in the ITER Engineering Design Activities. With the approval of the Detailed Design Report (DDR), the design work was concentrated on the requirements of operation, with only relatively minor changes to design concepts of major components. The FDR is the culmination of almost 6 years collaborative design and supporting technical work by the ITER Joint Central Team and Home Teams under the terms of the ITER EDA Agreement

  12. Energy savings Measures in Agriculture - Overview on the Basis of National Reports

    Visser, de C.L.M.; Buisonjé, de F.E.; Ellen, H.H.; Stanghellini, C.; Voort, van der M.P.J.

    2012-01-01

    The reduction of energy inputs in agricultural production is a process of practical implementation of a set of energy saving (ES) measures associated with a given type of production, farm infrastructure and managerial or organizational activities. In six national reports from Finland, Germany,

  13. [Molecular basis of the mutagenic and lethal effects of ultraviolet irradiation]: Progress report

    1988-01-01

    Studies on the molecular mechanisms by which Escherichia Coli and Micrococcus luteus repair pyrimidine dimers induced in their DNA by ultraviolet light are reported. The studies involve the isolation and enzymatic activity of the ucr system. The specific roles of ucr A and ucr B proteins are sought. In addition the expression of the ucr genes in mammalian cells is addressed. 35 refs. (DT)

  14. The mechanistic basis for psoriasis immunopathogenesis: translating genotype to phenotype. Report of a workshop, Venice, 2012.

    Bachelez, H; Viguier, M; Tebbey, P W; Lowes, M; Suárez-Fariñas, M; Costanzo, A; Nestle, F O

    2013-08-01

    The International Psoriasis Council, a global nonprofit organization dedicated to advancing psoriasis research and treatment, led an initiative to better define the pathogenic mechanisms that constitute psoriasis. In September 2012, a workshop was held at the 42nd Annual European Society for Dermatological Research in Venice, Italy. By assembling a panel of global dermatology and immunology experts, the objective was to evaluate the current status of the science explaining the mechanism of disease in psoriasis, e.g. dysregulation of the skin immune system and perturbations of epidermal homeostasis. The workshop consisted of four oral presentations, which addressed key topics in psoriasis, delivered by Hervé Bachelez (Paris, France), Antonio Costanzo (Rome, Italy), Michelle Lowes (New York, NY, U.S.A.) and Frank Nestle (London, U.K.). A global expert panel was assembled to stimulate dialogue and debate: Kevin Cooper (Cleveland, OH, U.S.A.), Michel Gilliet (Lausanne, Switzerland), Joerg Prinz (Munich, Germany), Martin Röcken (Tubingen, Germany), Jens Schroeder (Kiel, Germany), Manuelle Viguier (Paris, France), Mayte Suárez-Fariñas (New York, NY, U.S.A.) and Cristina Zielinski (Berlin, Germany). Collectively, the presentations demonstrated the significant advances in understanding immune regulation that have occurred over the past decade by virtue of the study of psoriasis subtypes, phenotypic manifestations and genetic associations. Elucidating the pathogenic and genetic basis of psoriasis holds the promise of a complete understanding of disease mechanisms, predictors of treatment response, novel drug development strategies and customized therapeutic regimens for the individual patient. © 2013 The Authors BJD © 2013 British Association of Dermatologists.

  15. Molecular basis for the mutagenic and lethal effects of ultraviolet irradiation. Progress report

    1977-01-01

    Pathways of DNA repair in bacteria and mammalian cells. Progress is reported on the following studies: genetic control of incision and excision in Escherichia coli; effects of binding proteins on the repair process in vitro; location of endonuclease - uv-irradiated DNA complexes; identification of eukaryotic repair mechanisms; nuclear complementation in HeLa cells; enzyme isolation from repair syndrome skin fibroblasts; and expression of the E. coli - SV40 hybrid DNA

  16. Online Monitoring Technical Basis and Analysis Framework for Large Power Transformers; Interim Report for FY 2012

    Nancy J. Lybeck; Vivek Agarwal; Binh T. Pham; Heather D. Medema; Kirk Fitzgerald

    2012-09-01

    The Light Water Reactor Sustainability program at Idaho National Laboratory (INL) is actively conducting research to develop and demonstrate online monitoring (OLM) capabilities for active components in existing Nuclear Power Plants. A pilot project is currently underway to apply OLM to Generator Step-Up Transformers (GSUs) and Emergency Diesel Generators (EDGs). INL and the Electric Power Research Institute (EPRI) are working jointly to implement the pilot project. The EPRI Fleet-Wide Prognostic and Health Management (FW-PHM) Software Suite will be used to implement monitoring in conjunction with utility partners: the Shearon Harris Nuclear Generating Station (owned by Duke Energy for GSUs, and Braidwood Generating Station (owned by Exelon Corporation) for EDGs. This report presents monitoring techniques, fault signatures, and diagnostic and prognostic models for GSUs. GSUs are main transformers that are directly connected to generators, stepping up the voltage from the generator output voltage to the highest transmission voltages for supplying electricity to the transmission grid. Technical experts from Shearon Harris are assisting INL and EPRI in identifying critical faults and defining fault signatures associated with each fault. The resulting diagnostic models will be implemented in the FW-PHM Software Suite and tested using data from Shearon-Harris. Parallel research on EDGs is being conducted, and will be reported in an interim report during the first quarter of fiscal year 2013.

  17. One explanatory basis for the discrepancy of reported prevalences of sleep paralysis among healthy respondents.

    Fukuda, K

    1993-12-01

    In a previous study, the author and coworkers found 39.8% of healthy young adults had experienced sleep paralysis. Some other studies reported prevalence as about the same or higher (i.e., 40.7% to 62.0%) than that previous estimate, while yet other studies, including Goode's work cited by ASDC and ASDA classifications, suggested much lower prevalences (i.e., 4.7% to 26.2%). The author tested the hypothesis that this discrepancy among the reported prevalences is partly due to the expression used in each questionnaire. University students who answered the questionnaire using the term 'transient paralysis' reported the lower prevalence (26.4%), while the second group of respondents who answered the questionnaire using the term kanashibari, the Japanese folklore expression for sleep paralysis, gave the higher prevalence (39.3%). The third group who answered the questionnaire with the term 'condition,' probably a rather neutral expression, marked the middle (31.0%) of these.

  18. The Second State of the Carbon Cycle Report: A Scientific Basis for Policy and Management Decisions

    Birdsey, R.; Mayes, M. A.; Reed, S.; Najjar, R.; Romero-Lankao, P.

    2017-12-01

    The second "State of the Carbon Cycle of North America Report" (SOCCR-2) includes an overview of the North American carbon budget and future projections, the consequences of changes to the carbon budget, details of the carbon budget in major terrestrial and aquatic ecosystems (including coastal ocean waters), information about anthropogenic drivers, and implications for policy and carbon management. SOCCR-2 includes new focus areas such as soil carbon, arctic and boreal ecosystems, tribal lands, and greater emphasis on aquatic systems and the role of societal drivers and decision making on the carbon cycle. In addition, methane is considered to a greater extent than before. SOCCR-2 will contribute to the next U.S. National Climate Assessment, as well as providing information to support science-based management decisions and policies that include climate change mitigation and adaptation in Canada, the United States, and Mexico. Although the Report is still in the review process, preliminary findings indicate that North America is a net emitter of carbon dioxide and methane to the atmosphere, and that natural sinks offset about 25% of emitted carbon dioxide. Combustion of fossil fuels represents the largest source of emissions, but show a decreasing trend over the last decade and a lower share (20%) of the global total compared with the previous decade. Forests, soils, grasslands, and coastal oceans comprise the largest carbon sinks, while emissions from inland waters are a significant source of carbon dioxide. The Report also documents the lateral transfers of carbon among terrestrial ecosystems and from terrestrial to near-coastal ecosystems, to complete the carbon cycle accounting. Further, the Report explores the consequences of rising atmospheric carbon dioxide on terrestrial and oceanic systems, and the capacity of these systems to continue to act as carbon sinks based on the drivers of future carbon cycle changes, including carbon-climate feedbacks

  19. Research and experience report 2007. Developments in the technical and legal basis of nuclear oversight

    2008-01-01

    This annual report issued by the Swiss Federal Nuclear Inspectorate (HSK) reviews the aims, duties and responsibilities of the inspectorate and the work done during 2007. In the area of reactor safety, the research covered materials and the deterministic and probabilistic analysis of incidents and their consequences. In the area of radiation protection, the protection of persons and the environment in the vicinity of nuclear facilities from ionising radiation is addressed. In this area, accurate metrology and research to improve dosimetry and radiation analysis is discussed. In the area of transport and waste management, the HSK is focussing its efforts on research into the geological strata suitable for the final storage of highly radioactive, long-lived waste. Human factors, organisation and safety culture are quoted as playing a major role in nuclear safety. According to the report, greater attention is being given to these factors by those bodies responsible for nuclear regulation. Appendices present an overview of work done, international activities and publications along with the ENSI's guidelines

  20. Research and experience report 2008. Developments in the technical and legal basis of nuclear oversight

    2009-04-01

    This annual report issued by the Swiss Federal Nuclear Inspectorate (ENSI) reviews research into regulatory safety and the work done during 2008. In the area of reactor safety, research - in addition to research into materials - was concentrated primarily on safety and reliability analyses. ENSI supports projects looking at ageing mechanisms such as fatigue, corrosion, embrittlement and the development of cracks under a range of environmental conditions. Topics such as the interaction between core meltdown and water and concrete as well as the development of methods and computer codes are covered. In the area of transport and waste management, ENSI is focussing its efforts on research into the geological strata suitable for the final storage of highly radioactive, long-lived waste. Human and organisational factors and safety culture now account for an increasing part of the work of this regulatory body. Appendices present an overview of work done, international activities, publications and the basic principles of the new ENSI guidelines

  1. Research and experience report 2015 - Developments in the technical and legal basis for nuclear oversight

    2016-04-01

    Projects in the research programme of the Swiss Federal Nuclear Safety Inspectorate (ENSI) contribute to the clarification of outstanding issues, establish fundamentals and develop the tools required for its regulatory activities. International projects deliver results that Switzerland could not achieve on its own and encourage international networking. The research on fuels and materials covers the reactor core and the multiple barriers for the retainment of radioactive materials. In 2015 the OECD Halden Reactor Project developed new methods for measuring the thermal conductivity of fuel and the creep of cladding materials during irradiation in the reactor and ageing processes. The PISA project of the Paul Scherrer Institute (PSI) focused on the deterministic and probabilistic assessment of the integrity of reactor pressure vessels. Under the auspices of the OECD's Nuclear Energy Agency, specific databases are being created on damage to passive metal components and electrical cables. The OECD FIRE project completed its report into the combination of fires with other events; half of these events are linked to electric arcing. ENSI research projects address external events such as earthquakes, flooding, aircraft crashes and explosions. A project of the American Society of Mechanical Engineers is investigating pre-stressed reinforced concrete slabs under explosive loads. Other OECD projects consider the effects of severe earthquakes on reinforced concrete walls and pipelines. The ROES PSI project is expanding the application of methods for assessing operator errors that can negatively influence the course of an accident. System behaviour and accident sequences in nuclear power plants are analysed in conditions ranging from normal operations through to accidents involving core meltdown. The results of computer models are used for the quantitative identification of plant risk in probabilistic safety analyses. The STARS PSI project improves the basic principles for

  2. Report of task group on the biological basis for dose limitation in the skin

    1989-08-01

    Researchers have drawn attention to what they consider inconsistencies in the manner in which ICRP have considered skin in relation to the effective dose equivalent. They urge that the dose to the skin should be considered routinely for inclusion in the effective dose equivalent in the context of protection of individuals and population groups. They note that even with a weighting factor of only 0.01 that the dose to the skin can be a significant contributor to the effective dose equivalent including skin for practical exposure conditions. In the case of many exposures the risk to the skin can be ignored but exposure in an uniformly contaminated cloud that might occur with 85 Kr the dose to the skin could contribute 60% of the stochastic risk if included in the effective dose equivalent with a W T of 0.01. Through the years and even today the same questions about radiation effects in the skin and dosimetry keep being asked. This report collates the available data and current understanding of radiation effects on the skin, and may make it possible to estimate risks more accurately and to improve the approach to characterizing skin irradiations. 294 refs., 29 figs

  3. Research and experience report 2009. Developments in the technical and legal basis of nuclear oversight

    2010-04-01

    physical transport processes and the management of all radioactive waste. ENSI supports research projects into the influence of human behaviour on incident management together with the development of requirement profiles for staff in the control rooms of nuclear power stations. Incidents in nuclear facilities provide concrete data on shortcomings and the potential for improvements in all areas of design and operation. Information on incidents in Swiss nuclear facilities is included in ENSI's (separate) Surveillance Report. Some incidents in nuclear facilities outside Switzerland were analysed in order to identify any relevance for Swiss nuclear facilities. There has been increase worldwide in the number of incidents involving the transport of loads. In Switzerland also, the Interim Storage Facility of Wuerenlingen AG reported an event in 2009 involving a lifting device. ENSI has increased its surveillance of cranes and other lifting devices. The Ringhals nuclear power plant (NPP) in Sweden had been operating at power for 72 days before it was discovered that the automatic initiation of the containment isolation system was not operational: the bypasses in the reactor protection system were not correctly removed. Investigations identified the absence of a clear demarcation between the responsibilities of operating and maintenance personnel. Although very improbable, a similar incident might occur in Switzerland; however it is very likely that it would be picked up during the obligatory functionality check. Nevertheless, ENSI considered it important that facilities took note of this incident. Following heavy rain, debris blocked the cooling water intake at the Cruas 4 NPP; this caused the main water sink to fail. At the Fessenheim 2 NPP, plant residues found their way into the cooling water system after the cleaning system failed. By such an incident in a Swiss NPP, the plant could be made safe because the Swiss NPPs are fed with water from their own wells or from additional

  4. Design basis for the copper/steel canister. Stage three. Final report

    Bowyer, W.H.

    1997-02-01

    The development of the copper/iron canister proposed for the containment of high-level waste in the Swedish disposal programme has been studied from the points of view of choice of materials, manufacturing technology and Q A. This report describes the observations on progress which has been made between March 1995 and February 1996 and the results of further literature studies. A first trial canister has been produced by SKB using a fabricated steel liner and an extruded copper tubular, a second one using a fabricated tubular is at an advanced stage. A change from a fabricated steel inner canister to a proposed cast canister has been justified by a criticality argument but the technology for producing a cast canister is at present untried. It is considered that such a change will require a significant development programme. The microstructure achieved in the extruded copper tubular for the first canister is unacceptable. An improved microstructure may be achieved by extruding at a lower temperature but this remains to be demonstrated. Similar problems exist with plate used for the fabricated tubular but some more favourable structures have been achieved already by this route. Seam welding of the first tubular failed through a suspected material problem. The second fabricated tubular welded without difficulty. However it was necessary to constrain it during welding and it subsequently distorted during machining. There was some evidence of hot tearing close to the weld. The distortion problem may be overcome by a stress relieving anneal but this could cause further grain size problems. 19 refs

  5. Green Train. Basis for a Scandinavian high-speed train concept. Final report, Pt. A

    Froeidh, Oskar

    2012-11-01

    The Green Train (in Swedish 'Groena Taaget') is a high-speed train concept, that is economical, environmentally friendly and attractive to travellers. It is suited to specific Nordic conditions with a harsh winter climate, often varying demand and mixed passenger and freight operations on non-perfect track. The main proposal is a train for speeds up to 250 km/h equipped with carbody tilt for short travelling times on electrified mainlines. The concept is intended to be a flexible platform for long-distance and fast regional passenger trains, interoperable in Scandinavia, i.e. Denmark, Norway and Sweden. The Groena Taaget programme delivers a collection of ideas, proposals and technical solutions for rail operators, infrastructure managers and industry. This is part A of the final report, dealing with market, economy and service aspects, with an emphasis on the areas where research has been done within the Groena Taaget research and development programme. Passenger valuations and economy in train traffic exposed to competition are controlling factors in the design of the train concept. One important measure to achieve better economy in the train traffic with 15% lower total costs and the possibility to reduce fares is to use wide-bodied trains that can accommodate more seats with good comfort. Travel on some studied routes in Sweden may increase by 30% compared to today's express trains through shorter travelling times, lower fares and more direct connections, which are possible with shorter, flexible trainsets. Groena Taaget will be designed to give good punctuality even during peak load periods. Doors, interior design, luggage handling and vestibules with lifts for disabled travellers must be dimensioned for full trains. A well-considered design reduces dwell times and delays. Capacity utilisation on the lines increases with greater speed differences between express trains and slower trains in mixed traffic. Punctual stops and skip-stop operation

  6. Research and experience report 2016 - Developments in the technical and legal basis for nuclear oversight

    2017-04-01

    Projects in the research programme of the Swiss Federal Nuclear Safety Inspectorate (ENSI) contribute to the clarification of outstanding issues, establish fundamentals and develop the tools required for its regulatory activities. International projects deliver results that Switzerland could not achieve on its own and encourage cross-border networking. The research on fuels and materials covers the reactor core and the multiple barriers for the retainment of radioactive materials especially concerning high burn-up rates and safety criteria. In 2016, the Studsvik Cladding Integrity Project in Sweden commissioned a new test facility to investigate the behaviour of fuel rods in loss of coolant accidents (LOCA). Research into structural materials focuses on ageing processes. In the NORA project at the Paul Scherrer Institute (PSI), platinum is injected into the cooling system with a view to reducing corrosion. Projects conducted under the auspices of the OECD's Nuclear Energy Agency (NEA) and relating to internal events and damage encourage the international exchange of information on incidents, accidents and component damage. Subject-specific databases are created on incidents involving fires or damage to passive metal components. In 2016 the OECD CODAP project prepared a report on reliability and integrity management in pressurised components. ENSI supports research projects on external events such as earthquakes, flooding, aircraft crashes and explosions. Within the OECD MECOS project, the behaviour of pipes subjected to powerful earthquakes was modelled; it showed improvements in the calculation of cyclic loading and on the limits for simulating elastic-plastic material behaviour under high loads. The impact of operator actions on incidents and accidents is the most important human factor in view of reducing uncertainty in probabilistic safety analyses, as well as the interfaces between humans and technical systems. System behaviour and accident sequences in

  7. Final report on 'biological effects of tritium as a basis of research and development in nuclear fusion'

    1987-12-01

    The National Institute of Radiological Sciences, Japan, has undertaken a special study of ''biological effects of tritium as a basis of research and development in nuclear fusion'' over a 5-year period from April 1981 through March 1986. This is a final report, covering incorporation and metabolism of tritium, physical, chemical, and cellular effects of tritium, tritium damage to the mammalian tissue, and human exposure to tritium. The report is organized into five chapters, including ''Study of incorporation of tritium into the living body and its in vivo behavior''; ''Physical and chemical studies for the determination of relative biological effectiveness''; ''Analytical study on biological effects of tritium in cultured mammalian cells''; ''Study of tritium effects on the mammalian tissue, germ cells, and cell transformation''; and ''Changes in the hemopoietic stem cells and lymphocyte subsets in humans after exposure to some internal emitters''. (Namekawa, K.)

  8. Design basis for the copper/steel canister. Stage five. Final report

    Bowyer, W.H.

    1999-05-01

    The development of the copper/iron canister which has been proposed by SKB for the containment of high level nuclear waste in the Swedish Program, has been studied by the present author from the points of view of choice of materials, manufacturing technology and quality assurance. This report describes the observations on progress that has been made between May-1-1998 and April-30-1999 and the result of further literature studies. Cast steel has been rejected in favour of cast iron as a candidate material for the load bearing liner. The nodular iron that was selected has been the subject of casting trials at several foundries. Early trials, using uphill feeding, met with limited success owing to difficulties feeding during solidification. Lessons from this trial led to a modification to the casting design to include extra cores that have the effect of reducing the need for feeding in the heaviest sections. Results using the new design and direct (downhill) casting are very promising. Castings appear to be sound and mechanical test results cast-on bars are within specification. Tensile test results from specimens cut from the casting have reduced ductility compared with the cast-on bars and this may be evidence of microstructural variations within the casting. The material specified for the overpack is OF (Oxygen Free) copper with 50 ppm of phosphorus added. Concentration limits have now been placed on impurity elements which are below those allowed in the OF specification. All current trials are using material from Outokompu produced from cathode on their OF(E) line, which delivers total impurity levels of less than 30 ppm excluding silver and phosphorus. The phosphorus addition is made using a master alloy added to the launder and this does not give good control of phosphorus level either within or between castings. Phosphorus is added to improve creep rates and creep strain to failure. The level is limited to 50 ppm in order to avoid difficulties, which it might

  9. Design basis for the copper/steel canister. Stage five. Final report

    Bowyer, W.H. [Meadow End Farm, Farnham (United Kingdom)

    1999-05-01

    The development of the copper/iron canister which has been proposed by SKB for the containment of high level nuclear waste in the Swedish Program, has been studied by the present author from the points of view of choice of materials, manufacturing technology and quality assurance. This report describes the observations on progress that has been made between May-1-1998 and April-30-1999 and the result of further literature studies. Cast steel has been rejected in favour of cast iron as a candidate material for the load bearing liner. The nodular ironthat was selected has been the subject of casting trials at several foundries. Early trials, using uphill feeding, met with limited success owing to difficulties feeding during solidification. Lessons from this trial led to a modification to the casting design to include extra cores that have the effect of reducing the need for feeding in the heaviest sections. Results using the new design and direct (downhill) casting are very promising. Castings appear to be sound and mechanical test results cast-on bars are within specification. Tensile test results from specimens cut from the casting have reduced ductility compared with the cast-on bars and this may be evidence of microstructural variations within the casting. The material specified for the overpack is OF (Oxygen Free) copper with 50 ppm of phosphorus added. Concentration limits have now been placed on impurity elements which are below those allowed in the OF specification. All current trials are using material from Outokompu produced from cathode on their OF(E) line, which delivers total impurity levels of less than 30 ppm excluding silver and phosphorus. The phosphorus addition is made using a master alloy added to the launder and this does not give good control of phosphorus level either within or between castings. Phosphorus is added to improve creep rates and creep strain to failure. The level is limited to 50 ppm in order to avoid difficulties, which it might

  10. PCDP [Prototypical Spent Fuel Consolidation Equipment Demonstration Project] design basis accident report 9315-P-103, Rev. A

    1987-12-01

    The Department of Energy's Office of Civilian Radioactive Waste Management (OCRWM) has identified a requirement to integrate the spent fuel rod consolidation design activities of each of several proposed geological repository facilities and the Monitored Retrievable Storage (MRS) facility, and to develop efficient and cost-effective equipment for the consolidation process. The equipment to be developed for the rod consolidation system will be required to operate in a dry environment at rates which can be appropriately scaled to approximate the waste management system acceptance rates, irrespective of repository geologic characteristics or the existence of an MRS facility in the waste management system. The purpose of this report is to identify and analyze the range of facility credible events and accident occurrences (from minor to the design basis accidents) and their causes and consequences. For each situation, the considerations to prevent or mitigate the event or accident is addressed

  11. The research project on technical information basis for aging management in Fukui and Kinki area (2nd report)

    Fujimura, Kimiya; Watarumi, Chikae; Toudou, Tsugihiko

    2009-01-01

    The Research Project on Technical Information Basis for Aging Management was initiated in 2006 by the Nuclear and Industrial Safety Agency (NISA) of the Ministry of Economy, Trade and Industry (METI), to promote aging management of domestic nuclear power plants. Its main objective was to improve the technical basis on which aging plants are regulated. Upon taking part in the R and D Roadmaps for Aging Management and Safe Long Term Operation, the experience and results of the participating organizations were considered and the following four topics were extracted. The regional characteristics of the Fukui and Kinki area where 15 nuclear power plants, mainly PWRs, and many nuclear related research institutes and universities are located, were also considered. 1) The improvement of pipe thinning management in nuclear power plants. 2) The development of inspection techniques to monitor the initiation and propagation of defects. 3) The development of a guideline for evaluating weld repair methods. 4) The development of a guideline for evaluating the degradation of main structures. To promote this research project, INSS has established a regional consortium (called the 'Fukui Regional Cluster' in coordination with universities, research institutes, electric utilities and venders in the Fukui and Kinki area. INSS is acting as of coordinator to make a contracts, facilitate execution, and compile annual reports. In FY2008, 11 research subjects were proposed for this project and all were accepted. Of these, 4 subjects were related to the first topic (pipe thinning), 3 subjects were related to the second topic (inspection technique) and I subject was related to each of the other two topics (weld repair and main structures). All the subjects have been completed, fulfilling the requirements and expectations. (author)

  12. The research project on technical information basis for aging management in Fukui and Kinki area. 3rd report

    Fujimura, Kimiya; Watarumi, Chikae; Toudou, Tsugihiko

    2010-01-01

    The Research Project on Technical Information Basis for Aging Management was initiated in FY2006 by the Nuclear and Industrial Safety Agency (NISA) of the Ministry of Economy, Trade and Industry (METI), to promote aging management of domestic nuclear power plants. Its main objective was to improve the technical basis on which aging nuclear power plants are regulated. Upon taking part in the R and D Roadmaps for Aging Management and Safe Long Term Operation, the experiences and achievements of the participating organizations were taken into account and the following four topics were chosen. The regional characteristics of the Fukui and Kinki area where 15 nuclear power plants, mainly PWRs, and many nuclear related research institutes and universities are located, were also considered. (1) The improvement of pipe thinning management in nuclear power plants, (2) The development of inspection techniques to monitor the initiation and propagation of defects, (3) The development of a guideline for evaluating weld repair methods, (4) The development of a guideline for evaluating the degradation of main structures. To promote this research project, INSS has established a regional consortium (called the 'Fukui Regional Cluster' in coordination with universities, research institutes, electric utilities and venders in the Fukui and Kinki area. INSS is acting as a coordinator to make contracts, facilitate execution, and compile annual reports. In FY2009, 11 research subjects were proposed for this project and all were accepted. Of these, 4 subjects were related to the first topic (pipe thinning), 3 subjects to the second topic (inspection technique) and 1 subject to each of the other two topics (weld repair and main structures). All the subjects have been completed, fulfilling the requirements and expectations. (author)

  13. The research project on technical information basis for aging management in Fukui and Kinki area. Final report

    Fujimura, Kimiya; Nagayama, Shigeru; Watarumi, Chikae; Toudou, Tsugihiko

    2011-01-01

    The Research Project on Technical Information Basis for Aging Management was initiated in FY2006 by the Nuclear and Industrial Safety Agency (NISA) of the Ministry of Economy, Trade and Industry (METI) as a five-year program effectively, to promote aging management of domestic nuclear power plants. Its main objective was to improve the technical basis on which aging nuclear power plants are regulated. Upon taking part in the technical strategy map for Aging Management and Safe Long Term Operation, the experiences and achievements of the participating organizations were taken into account and the following four topics were chosen. The regional characteristics of the Fukui and Kinki area where 15 nuclear power plants, mainly PWRs, and many nuclear related research institutes and universities are located, were also considered. 1) The improvement of pipe thinning management in nuclear power plants, 2) The development of inspection techniques to monitor the initiation and propagation of defects, 3) The development of a guideline for evaluating weld repair methods, 4) The development of a guideline for evaluating the degradation of main structures. To promote this research project, INSS has established a regional consortium (called the 'Fukui Regional Cluster' in coordination with universities, research institutes, electric utilities and venders in the Fukui and Kinki area. INSS is acting as a coordinator to make contracts, facilitate execution, and compile annual reports. In FY2010, 11 continuing research subjects were proposed for this project and all were accepted. Of these, 5 subjects were related to the first topic (pipe thinning), 4 subjects to the second topic (inspection technique) and 1 subject to each of the other two topics (weld repair and main structures). All the subjects have been completed, fulfilling the requirements and expectations. (author)

  14. Neurosurgical treatment of drug-resistant epilepsy on the basis of a fusion of MRI and SPECT images - case report

    Jurkiewicz, E.; Bekiesinska-Figatowska, M.; Misko, J.; Kaminska, A.; Kwiatkowski, S.; Terczynska, I.

    2010-01-01

    Background: Epilepsy concerns at least 0.5% of population and in most of the cases (approx. 70%) can be treated pharmacologically, which helps to prevent seizures. In all other patients, such a treatment does not produce the desired results. Their condition may require neurosurgical management. The aim of this work was to fuse anatomical MRI images and functional SPECT images in patients with drug resistant epilepsy, without structural changes on MRI or with changes so severe that it would be impossible to establish which ones are responsible for seizures. The authors presented a case of a child subjected to a neurosurgical procedure carried out on the basis of the fused MRI and SPECT images. Case Report: A seven-year-old boy with an extensive defect of the right hemisphere (cortical dysplasia with multiple balloon-like cells) operated on three times due to a history of treatment-resistant seizures present since the age of one. A subsequent MRI examination was performed with magnetic field intensity of 1.5 T, within a routine epilepsy protocol applying volumetric thin-slice T1-weighted images. Next, in the interictal period, a SPECT examination was performed with the use of the 99mT c-labelled ethyl cysteinate dimer ( 99mT cECD). For fusion and postprocessing, the following software was used: PMOD (Biomedical Image Quantification PMOD Technologies) with PFUS (Flexible Image Matching and Fusion Tool) and a program for a quantitative analysis of counts in the region of interest, so called VOI Constructor (Volume of Interest Constructor). On the basis of the fusion of images, the boy was subjected to the next operation procedure. The remaining fragments of the right frontal and parietal lobe adjacent to the occipital lobe were removed. Seizure remission was obtained and it was already 31 months long when we were writing this article. Conclusions: Owing to this multi-stage procedure, it was possible to avoid a total anatomical and functional hemispherectomy. This

  15. Report of the working group 'Regulatory requirements on AM - Concept of nuclear and radiation safety during beyond-design-basis accidents'

    Bobaly, P.

    2001-01-01

    The developed working group report contains the following main paragraphs: legal basis and basis for regulatory requirements for on-site and off-site Accident Management (AM), regulatory requirements or recommendations for on-site AM and for emergency preparedness, background information concerning the implementation and review of an AM program as a basis for an AM guideline. Overview about AM/SAM implementation in member countries of the SAMINE project; measure and candidates for high level actions based upon US SAMG; interactions of severe accident research and the regulatory positions, relationship between different components of an accident management programme are also given

  16. Assessing participation in the ACL injured population: Selecting a patient reported outcome measure on the basis of measurement properties.

    Letchford, Robert; Sparkes, Valerie; van Deursen, Robert W M

    2015-06-01

    A return to pre injury activity participation remains a common but often elusive goal following ACL injury. Investigations to improve our understanding of participation restrictions are limited by inconsistent use of insufficiently investigated measurement tools. The aim of this study was to follow the consensus based standards for the selection of health measurement instruments (COSMIN) guideline to provide a comparative evaluation of four patient reported outcomes (PROMs) on the basis of measurement properties. This will inform recommendations for measuring participation of ACL injured subjects, particularly in the United Kingdom (UK) National Health Service (NHS). Thirteen criteria were compiled from the COSMIN guideline. These included reliability, measurement error, content validity, construct validity, responsiveness and interpretability. Data from 51 subjects collected as part of a longitudinal observational study of recovery over the first year following ACLR was used in the analysis. Of the thirteen criteria, the required standard was met in 11 for Tegner, 11 for International Knee Documentation Committee (IKDC), 6 for Cincinnati Sports Activity Scale (CSAS) and 6 for Marx. The two weaknesses identified for the Tegner are more easily compensated for during interpretation than those in the IKDC; for this reason the Tegner is the recommended PROM. The Tegner activity rating scale performed consistently well in respect of all measurement properties in this sample, with clear benefits over the other PROMs. The measurement properties presented should be used to inform implementation and interpretation of this outcome measure in clinical practice and research. Level II prospective study. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Patient safety with reference to the occurrence of adverse events in admitted patients on the basis of incident reporting in a tertiary care hospital in North India

    Moonis Mirza; Farooq A. Jan; Rauf Ahmad Wani; Fayaz Ahmad Sofi

    2016-01-01

    Background: A good quality report should lend itself for detailed analysis of the chain of events that lead to the incident. This knowledge can then be used to consider what interventions, and at what level in the chain, can prevent the incident from occurring again. Aim was to study the occurrence of adverse events on the basis of incident reporting. Methods: Critical analysis of incident reporting of adverse events taking place in admitted patients for one year by using WHO Structured q...

  18. Technical basis for the ITER-FEAT outline design. Progress in resolving open design issues from the outline design report

    2000-01-01

    In this publication the technical basis for the ITER-FEAT outline design is presented. It comprises the Plant Design Specifications, the Safety Principles and Environmental Criteria, the Site Requirements and Site Design Assumptions. The outline of the key features of the ITER-FEAT design includes main physical parameters and assessment, design overview and preliminary safety assessment, cost and schedule

  19. Preventive maintenance basis: Volume 24 -- Battery -- flooded lead-acid (lead-calcium, lead antimony, plante). Final report

    Worledge, D.; Hinchcliffe, G.

    1997-12-01

    US nuclear power plants are implementing preventive maintenance (PM) tasks with little documented basis beyond fundamental vendor information to support the tasks or their intervals. The Preventive Maintenance Basis project provides utilities with the technical basis for PM tasks and task intervals associated with 40 specific components such as valves, electric motors, pumps, and HVAC equipment. This document provides a program of preventive maintenance tasks suitable for application to flooded lead-acid batteries. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used in conjunction with material from other sources, to develop a complete PM program or to improve an existing program. This document provides a program of preventive maintenance (PM) tasks suitable for application to flooded lead-acid batteries. The PM tasks that are recommended provide a cost-effective way to intercept the causes and mechanisms that lead to degradation and failure. They can be used, in conjunction with material from other sources, to develop a complete PM program or to improve an existing program. Users of this information will be utility managers, supervisors, system engineers, craft technicians, and training instructors responsible for developing, optimizing, or fine-tuning PM programs

  20. Principles of Textual Communication. On the Basis of Polish Press Reports after President Obama’s 2009 Inauguration

    Piotr P. Chruszczewski

    2009-11-01

    Full Text Available On the basis of the assumption that any discourse is a highly context-dependent, and dynamically changing phenomenon of textual nature, and with reference to the fact that there may be used in linguistic research certain standards of textuality, the paper shows that the standards can be grouped into, e.g., three general sections (text-oriented, sender-oriented and context-oriented which can be used as a starting point for further research in the study of textlinguistics and journalistic discourse.

  1. A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making

    Ågerstrand, Marlene; Christiansen, Sofie; Hanberg, Annika

    2018-01-01

    This is a call for action to scientific journals to introduce reporting requirements for toxicity and ecotoxicity studies. Such reporting requirements will support the use of peer-reviewed research studies in regulatory decision-making. Moreover, this could improve the reliability...... and reproducibility of published studies in general and make better use of the resources spent in research....

  2. A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making

    Ågerstrand, Marlene; Christiansen, Sofie; Hanberg, Annika

    2018-01-01

    This is a call for action to scientific journals to introduce reporting requirements for toxicity and ecotoxicity studies. Such reporting requirements will support the use of peer-reviewed research studies in regulatory decision-making. Moreover, this could improve the reliability and reproducibi...

  3. After Action Report:Idaho National Laboratory (INL) 2014 Multiple Facility Beyond Design Basis (BDBE) Evaluated Drill October 21, 2014

    Barnes, V. Scott [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-12-01

    On October 21, 2014, Idaho National Laboratory (INL), in coordination with local jurisdictions, and Department of Energy (DOE) Idaho Operations Office (DOE ID) conducted an evaluated drill to demonstrate the ability to implement the requirements of DOE O 151.1C, “Comprehensive Emergency Management System” when responding to a beyond design basis event (BDBE) scenario as outlined in the Office of Health, Safety, and Security Operating Experience Level 1 letter (OE-1: 2013-01). The INL contractor, Battelle Energy Alliance, LLC (BEA), in coordination with CH2M-WG Idaho, LLC (CWI), and Idaho Treatment Group LLC (ITG), successfully demonstrated appropriate response measures to mitigate a BDBE event that would impact multiple facilities across the INL while protecting the health and safety of personnel, the environment, and property. Offsite response organizations participated to demonstrate appropriate response measures.

  4. Ground water dating on the basis of the 14C content of dissolved humic and fulvic acids. Final report

    Kim, J.I.; Artinger, R.; Buckau, G.; Kardinal, C.; Geyer, S.; Wolf, M.; Halder, H.; Fritz, P.

    1995-05-01

    The groundwater dating on the basis of the 14 C content of dissolved organic carbon (DOC) is studied. Fulvic acids (FA) and humic acids (HA) are used as DOC fractions. In addition, the groundwaters are dated with the 14 C content of the dissolved inorganic carbon (DIC). The isotopic contents of 2 H, 3 H, 13 C, 15 N, 18 O, and 34 S of groundwater and humic substances are alse determined. The isolated humic substances are characterized with regard to their chemical composition as well as their molecular size and spectroscopic properties. For aquifer systems which have a neglectable content of sedimentary organic carbon (SOC), the 14 C dating of FA show plausible groundwater ages. In aquifer systems with a high SOC content, the mixing of 14 C free FA from sediment partly falsifies the 14 C groundwater age as determined by dissolved FA. Due to the high transfer of HA from sediment to groundwater, HA are less suitable for groundwater dating. The FA characterization allows the distinction between FA of sedimentary origin and FA which infiltrate with seepage water. Several starting points for a correction of the calculated 14 C ages of FA exist. The results indicate, 14 C groundwater dating with fulvic acids is a valuable expansion of groundwater dating methods. (orig.) [de

  5. Molecular basis for the mutagenic and lethal effects of ultraviolet irradiation. Progress report, December 1, 1977--November 30, 1978

    Grossman, L.

    1978-07-01

    Our earlier work on the chemical basis of mutagenesis led to certain chemical generalities necessary to explain how certain mutagens such as UV light and hydroxylamine functioned in information transfer systems (replicative, transcriptive and translational). When such modifications were applied to biologically active DNA in a controlled manner biological expression was non-stoichiometric because much of the damage was removed from the DNA by repair systems. Our efforts were then directed to these systems which led to: the isolation, purification and characterization of endonucleases responsible for the first and controlling step in DNA repair referred to as incision in both M. luteus and E. coli; the isolation, purification and characterization of exonucleases responsible for the removal or excision of damaged nucleotides in M. luteus and human placental trophoblasts; the repair of UV damaged biologically active transforming and transfecting DNAs by purified endonucleases, exonucleases, DNA polymerase I and polynucleotide ligase from M. luteus and E. coli; the characterization of the dual gene control for incision phenomenon in M. luteus and E. coli; and isolation, purification and characterization of repair enzymes from human placenta

  6. Journal maps on the basis of Scopus data: a comparison with the Journal Citation Reports of the ISI

    Leydesdorff, L.; de Moya-Anegon, F.; Guerrero-Bote, V.P.

    2010-01-01

    Using the Scopus dataset (1996-2007) a grand matrix of aggregated journal-journal citations was constructed. This matrix can be compared in terms of the network structures with the matrix contained in the Journal Citation Reports (JCR) of the Institute of Scientific Information (ISI). Because the

  7. The Use of Probability Theory as a Basis for Planning and Controlling Overhead Costs in Education and Industry. Final Report.

    Vinson, R. B.

    In this report, the author suggests changes in the treatment of overhead costs by hypothesizing that "the effectiveness of standard costing in planning and controlling overhead costs can be increased through the use of probability theory and associated statistical techniques." To test the hypothesis, the author (1) presents an overview of the…

  8. Analysis of fuel-handling incidents (safety analysis detailed report no. 5). PEC Brasimone reactor design basis accidents

    1988-01-15

    The features covered by this report deal with the equipment and cells in which the handling, examination, measurement, conditioning and storage of core elements are carried out. The operations covered range from the receiving of new element shipments to their insertion in the vessel (excluding handling inside the vessel itself, which is covered in report no. 2) and removal of the spent-elements from the vessel, transfer to their final storage and their ultimate loading into containers for transport outside the plant. The incident analysis along the path of the spent fuel was conducted with the same method adopted for other plant systems. It is treated separately here because the operation of the handling system is practically autonomous from reactor operation.

  9. Demand of authorization to create the 'Flamanville 3' Basis Nuclear Installation. Synthesis report of the technical examination

    2007-02-01

    The present report has for objective to present to the College of Asn a synthesis of the technical instruction piloted by the services of Asn and realized by their technical supports (I.R.S.N., G.P.R., S.P.N.) during the period 2001-2006. After a reminder of the conditions of the examination of the safety options of the project EPR made between 1993 and 2000, this report explains the progress and the modalities of the instruction realized from 2001 till 2006. It draws up then, besides a notice of the Asn services at request of creation authorization, a synthesis of the technical examination realized according to axes presented on the fig 1. Finally, it presents the main lines of the examination that it would stay to realize if the creation authorization was delivered. (N.C.)

  10. Oral cancer statistics in India on the basis of first report of 29 population-based cancer registries

    Sharma, Swati; Satyanarayana, L; Asthana, Smitha; Shivalingesh, KK; Goutham, Bala Subramanya; Ramachandra, Sujatha

    2018-01-01

    Objectives: To summarize and provide an overview of age-specific oral cancer incidence reported in 29 population-based cancer registry in India. Materials and Methods: Secondary data on age-adjusted rates (AARs) of incidence of oral cancer and other associated sites for all ages (0–75 years) were collected from the report of the National Cancer Registry Programme 2012–2014 in 29 population-based control registries. Results: Among both males and females, mouth cancer had maximum Age adjusted incidence rates (64.8) in the central zone, while oropharynx cancer had minimum AAR (0) in all regions. Conclusion: Oral cancer incidence increases with age with typical pattern of cancer of associated sites of oral cavity seen in the northeast region. PMID:29731552

  11. Measurement as basis for emission reductions: VOC, PAH, PCB and dioxins in air in Ostrava. Final report

    Braathen, O.A.

    1996-12-31

    As part of the cooperation between Norway and the Czech Republic on environment protection, a project was carried out in Ostrava, Czech Republic, to transfer competence to Ostrava such that measurements of selected organic contaminants in air could be measured. The focus was on volatile organic compounds (VOC), polycyclic aromatic hydrocarbons (PAH), polychlorinated biphenyls (PBC) and dioxin. This work also included acquiring and establishing equipment and analysis methodology. This is the final report from the project. 9 figs., 12 tabs.

  12. Analysis and evaluation of the ASTEC model basis on fission product and aerosol release phenomena from melts. 3. Technical report

    Agethen, K.; Koch, M.K.

    2016-04-01

    The present report is the 3 rd Technical Report within the research project ''ASMO'' founded by the German Federal Ministry for Economic Affairs and Energy (BMWi 1501433) and projected at the Chair of Energy Systems and Energy Economics (LEE) within the workgroup Reactor Simulation and Safety at the Ruhr-Universitaet Bochum (RUB). The focus in this report is set on the release of fission products and the contribution to the source term, which is formed in the late phase after failure of the reactor pressure vessel during MCCI. By comparing the RUB simulation results including the fission product release rates with further simulations of GRS and VEIKI it can be indicated that the simulations have a high sensitivity in respect to the melting point temperature. It can be noted that the release rates are underestimated for most fission product species with the current model. Especially semi-volatile fission products and the lanthanum release is underestimated by several orders of magnitude. Based on the ACE experiment L2, advanced considerations are presented concerning the melt temperature, the gas temperature, the segregation and a varied melt configuration. Furthermore, the influence of the gas velocity is investigated. This variation of the gas velocity causes an underestimation of the release rates compared to the RUB base calculation. A model extension to oxidic species for lanthanum and ruthenium shows a significant improvement of the simulation results. In addition, the MEDICIS module has been enhanced to document the currently existing species, are displayed in a *.ist-file. This expansion shows inconsistencies between the melt composition and the fission product composition. Based on these results, there are still some difficulties regarding the release of fission products in the MEDICIS module and the interaction with the material data base (MOB) which needs further investigation.

  13. Musculocutaneous nerve substituting for the distal part of radial nerve: A case report and its embryological basis

    A S Yogesh

    2011-01-01

    Full Text Available In the present case, we have reported a unilateral variation of the radial and musculocutaneous nerves on the left side in a 64-year-old male cadaver. The radial nerve supplied all the heads of the triceps brachii muscle and gave cutaneous branches such as lower lateral cutaneous nerve of the arm and posterior cutaneous nerve of forearm. The radial nerve ended without continuing further. The musculocutaneous nerve supplied the brachioradialis, extensor carpi radialis longus and extensor carpi radialis brevis muscles. The musculocutaneous nerve divided terminally into two branches, superficial and deep. The deep branch of musculocutaneous nerve corresponded to usual deep branch of the radial nerve while the superficial branch of musculocutaneous nerve corresponded to usual superficial branch of the radial nerve. The dissection was continued to expose the entire brachial plexus from its origin and it was found to be normal. The structures on the right upper limb were found to be normal. Surgeons should keep such variations in mind while performing the surgeries of the upper limb.

  14. CHART OF ACCOUNTS OF THE RUSSIAN FEDERATION SHOULD BE DETAILED WITH REFORMING OF AN ACCOUNTING REPORTING ON THE BASIS OF THE INTERNATIONAL FINANCIAL REPORTING STANDARDS (IFRS

    Gegetsik A. Tovmasyan

    2013-01-01

    Full Text Available The article deals with the problem related to information base of accounting (financial reporting, which depends on conducting accounting and creation of detailed classification of chart of accounts of the Russian Federation. It is offered to change the structure of the balance sheet and the report on changes of the capital in the Russian Federation with introduction of “paid-in capital” indicator which not only unifies the reporting according to IFRS, but also will allow objectively estimating and predicting results and risks of both business activity and investment activity.

  15. Theoretical basis for dosimetry

    Carlsson, G.A.

    1985-01-01

    Radiation dosimetry is fundamental to all fields of science dealing with radiation effects and is concerned with problems which are often intricate as hinted above. A firm scientific basis is needed to face increasing demands on accurate dosimetry. This chapter is an attempt to review and to elucidate the elements for such a basis. Quantities suitable for radiation dosimetry have been defined in the unique work to coordinate radiation terminology and usage by the International Commission on Radiation Units and Measurements, ICRU. Basic definitions and terminology used in this chapter conform with the recent ''Radiation Quantities and Units, Report 33'' of the ICRU

  16. Climate Change 2013. The Physical Science Basis. Working Group I Contribution to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change - Abstract for decision-makers

    Stocker, Thomas F.; Qin, Dahe; Plattner, Gian-Kasper; Tignor, Melinda M.B.; Allen, Simon K.; Boschung, Judith; Nauels, Alexander; Xia, Yu; Bex, Vincent; Midgley, Pauline M.; Alexander, Lisa V.; Allen, Simon K.; Bindoff, Nathaniel L.; Breon, Francois-Marie; Church, John A.; Cubasch, Ulrich; Emori, Seita; Forster, Piers; Friedlingstein, Pierre; Gillett, Nathan; Gregory, Jonathan M.; Hartmann, Dennis L.; Jansen, Eystein; Kirtman, Ben; Knutti, Reto; Kumar Kanikicharla, Krishna; Lemke, Peter; Marotzke, Jochem; Masson-Delmotte, Valerie; Meehl, Gerald A.; Mokhov, Igor I.; Piao, Shilong; Plattner, Gian-Kasper; Dahe, Qin; Ramaswamy, Venkatachalam; Randall, David; Rhein, Monika; Rojas, Maisa; Sabine, Christopher; Shindell, Drew; Stocker, Thomas F.; Talley, Lynne D.; Vaughan, David G.; Xie, Shang-Ping; Allen, Myles R.; Boucher, Olivier; Chambers, Don; Hesselbjerg Christensen, Jens; Ciais, Philippe; Clark, Peter U.; Collins, Matthew; Comiso, Josefino C.; Vasconcellos de Menezes, Viviane; Feely, Richard A.; Fichefet, Thierry; Fiore, Arlene M.; Flato, Gregory; Fuglestvedt, Jan; Hegerl, Gabriele; Hezel, Paul J.; Johnson, Gregory C.; Kaser, Georg; Kattsov, Vladimir; Kennedy, John; Klein Tank, Albert M.G.; Le Quere, Corinne; Myhre, Gunnar; Osborn, Timothy; Payne, Antony J.; Perlwitz, Judith; Power, Scott; Prather, Michael; Rintoul, Stephen R.; Rogelj, Joeri; Rusticucci, Matilde; Schulz, Michael; Sedlacek, Jan; Stott, Peter A.; Sutton, Rowan; Thorne, Peter W.; Wuebbles, Donald

    2013-10-01

    The Working Group I contribution to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) provides a comprehensive assessment of the physical science basis of climate change. It builds upon the Working Group I contribution to the IPCC's Fourth Assessment Report in 2007 and incorporates subsequent new findings from the Special Report on Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation, as well as from research published in the extensive scientific and technical literature. The assessment considers new evidence of past, present and projected future climate change based on many independent scientific analyses from observations of the climate system, paleo-climate archives, theoretical studies of climate processes and simulations using climate models. During the process of scoping and approving the outline of its Fifth Assessment Report, the IPCC focussed on those aspects of the current understanding of the science of climate change that were judged to be most relevant to policy-makers. In this report, Working Group I has extended coverage of future climate change compared to earlier reports by assessing near-term projections and predictability as well as long-term projections and irreversibility in two separate chapters. Following the decisions made by the Panel during the scoping and outline approval, a set of new scenarios, the Representative Concentration Pathways, are used across all three Working Groups for projections of climate change over the 21. century. The coverage of regional information in the Working Group I report is expanded by specifically assessing climate phenomena such as monsoon systems and their relevance to future climate change in the regions. The Working Group I Report is an assessment, not a review or a text book of climate science, and is based on the published scientific and technical literature available up to 15 March 2013. Underlying all aspects of the report is a

  17. ITER technical basis

    NONE

    2002-01-01

    Following on from the Final Report of the EDA(DS/21), and the summary of the ITER Final Design report(DS/22), the technical basis gives further details of the design of ITER. It is in two parts. The first, the Plant Design specification, summarises the main constraints on the plant design and operation from the viewpoint of engineering and physics assumptions, compliance with safety regulations, and siting requirements and assumptions. The second, the Plant Description Document, describes the physics performance and engineering characteristics of the plant design, illustrates the potential operational consequences foe the locality of a generic site, gives the construction, commissioning, exploitation and decommissioning schedule, and reports the estimated lifetime costing based on data from the industry of the EDA parties.

  18. ITER technical basis

    2002-01-01

    Following on from the Final Report of the EDA(DS/21), and the summary of the ITER Final Design report(DS/22), the technical basis gives further details of the design of ITER. It is in two parts. The first, the Plant Design specification, summarises the main constraints on the plant design and operation from the viewpoint of engineering and physics assumptions, compliance with safety regulations, and siting requirements and assumptions. The second, the Plant Description Document, describes the physics performance and engineering characteristics of the plant design, illustrates the potential operational consequences foe the locality of a generic site, gives the construction, commissioning, exploitation and decommissioning schedule, and reports the estimated lifetime costing based on data from the industry of the EDA parties

  19. Pleural sarcoidosis diagnosed on the basis of an increased CD4/CD8 lymphocyte ratio in pleural effusion fluid: a case report.

    Kumagai, Toru; Tomita, Yasuhiko; Inoue, Takako; Uchida, Junji; Nishino, Kazumi; Imamura, Fumio

    2015-08-14

    Pleural effusion induced by sarcoidosis is rare, and pleural sarcoidosis is often diagnosed by thoracoscopic surgery. The diagnosis of pleural sarcoidosis using thoracentesis may be less invasive when sarcoidosis is already diagnosed histologically in more than one organ specimen. Here we report the case of a 64-year-old woman with pleural sarcoidosis diagnosed on the basis of an increased CD4/CD8 lymphocyte ratio in pleural effusion fluid obtained by thoracentesis. This case report is important because it highlights the usefulness of the CD4/CD8 lymphocyte ratio in pleural effusion as an indicator of pleural involvement of sarcoidosis. A 64-year-old Japanese woman visited our hospital with an initial symptom of dyspnea on exertion for a period of 4 months. Chest computed tomography showed bilateral hilar and multiple mediastinal lymphadenopathy, multiple small nodular shadows in her bilateral lungs, small nodular shadows along the interlobar pleura, and bilateral pleural effusion. Her serum angiotensin-converting enzyme and soluble interleukin-2 receptor levels were elevated. Histological analysis of a resected subcutaneous nodule, and biopsy specimens from a right mediastinal lymph node and from her right lung revealed non-caseous epithelioid granulomas. Her bronchoalveolar lavage fluid exhibited a predominance of lymphocytes together with an increase in the CD4/CD8 lymphocyte ratio. The lymphocytic predominance and the increased CD4/CD8 lymphocyte ratio were also detected in the right-sided pleural effusion fluid obtained by thoracentesis. We diagnosed sarcoidosis with pleural involvement. Because pleural effusion did not resolve spontaneously and her symptom of dyspnea on exertion worsened, corticosteroid therapy was initiated, which ameliorated the sarcoidosis and the pleuritis. Analysis of the CD4/CD8 lymphocyte ratio in pleural effusion fluid obtained by thoracentesis may be helpful for the diagnosis of pleural sarcoidosis when the diagnosis is already made

  20. Information basis for developing comprehensive waste management system. US-Japan joint nuclear energy action plan waste management working group phase I report (Joint research)

    Yui, Mikazu; Ishikawa, Hirohisa; Umeki, Hiroyuki; Hioki, Kazumasa; Naito, Morimasa; Makino, Hitoshi; Oda, Chie; Tachi, Yukio; Mitsui, Seiichiro; Shibata, Masahiro; Watanabe, Atsuo; Yoshino, Kyoji; Seo, Toshihiro; Miyamoto, Yoichi; Nutt, Mark; Peters, Mark; Bresee, James; Lesica, Sue; Schwab, Patrick; Gomberg, Steve; Jones, Jay; Halsey, Bill; Marra, John; Vienna, John; Gombert, Drik; McMahon, Kevin; James, Scott; Caporuscio, Florie

    2010-05-01

    The activity of Phase I of the Waste Management Working Group under the United States - Japan Joint Nuclear Energy Action Plan started in 2007. The US-Japan JNEAP is a bilateral collaborative framework to support the global implementation of safe, secure, and sustainable, nuclear fuel cycles (referred to in this document as fuel cycles). The Waste Management Working Group was established by strong interest of both parties, which arise from the recognition that development and optimization of waste management and disposal system(s) are central issues of the present and future nuclear fuel cycles. This report summarizes the activity of the Waste Management Working Group that focused on consolidation of the existing technical basis between the U.S. and Japan and the joint development of a plan for future collaborative activities. Firstly, the political/regulatory frameworks related to nuclear fuel cycles in both countries were reviewed. The various advanced fuel cycle scenarios that have been considered in both countries were then surveyed and summarized. The working group established the working reference scenario for the future cooperative activity that corresponds to a fuel cycle scenario being considered both in Japan and the U.S. This working scenario involves transitioning from a once-through fuel cycle utilizing light water reactors to a one-pass uranium-plutonium fuel recycle in light water reactors to a combination of light water reactors and fast reactors with plutonium, uranium, and minor actinide recycle, ultimately concluding with multiple recycle passes primarily using fast reactors. Considering the scenario, current and future expected waste streams, treatment and inventory were discussed, and the relevant information was summarized. Second, the waste management/disposal system optimization was discussed. Repository system concepts were reviewed, repository design concepts for the various classifications of nuclear waste were summarized, and the factors

  1. Information basis for developing comprehensive waste management system-US-Japan joint nuclear energy action plan waste management working group phase I report.

    Nutt, M.; Nuclear Engineering Division

    2010-05-25

    The activity of Phase I of the Waste Management Working Group under the United States - Japan Joint Nuclear Energy Action Plan started in 2007. The US-Japan JNEAP is a bilateral collaborative framework to support the global implementation of safe, secure, and sustainable, nuclear fuel cycles (referred to in this document as fuel cycles). The Waste Management Working Group was established by strong interest of both parties, which arise from the recognition that development and optimization of waste management and disposal system(s) are central issues of the present and future nuclear fuel cycles. This report summarizes the activity of the Waste Management Working Group that focused on consolidation of the existing technical basis between the U.S. and Japan and the joint development of a plan for future collaborative activities. Firstly, the political/regulatory frameworks related to nuclear fuel cycles in both countries were reviewed. The various advanced fuel cycle scenarios that have been considered in both countries were then surveyed and summarized. The working group established the working reference scenario for the future cooperative activity that corresponds to a fuel cycle scenario being considered both in Japan and the U.S. This working scenario involves transitioning from a once-through fuel cycle utilizing light water reactors to a one-pass uranium-plutonium fuel recycle in light water reactors to a combination of light water reactors and fast reactors with plutonium, uranium, and minor actinide recycle, ultimately concluding with multiple recycle passes primarily using fast reactors. Considering the scenario, current and future expected waste streams, treatment and inventory were discussed, and the relevant information was summarized. Second, the waste management/disposal system optimization was discussed. Repository system concepts were reviewed, repository design concepts for the various classifications of nuclear waste were summarized, and the factors

  2. Research and experience report 2012. Developments in the technical and legal basis of nuclear oversight; Erfahrungs- und Forschungsbericht 2012. Entwicklungen im Bereich der Grundlagen der nuklearen Aufsicht

    NONE

    2013-04-15

    The Swiss Federal Nuclear Safety Inspectorate (ENSI) acts upon the basis of the latest developments in science and technology. ENSI supports and coordinates safety research, the results of which influence directly its Guidelines, individual decisions and resources. Research projects also serve training purposes and maintain competence within ENSI and its experts. The research in fuels and materials covers the reactor core and the graded approach to barriers used for the confinement of radioactive materials. Based on test results from accidents involving a loss of coolant ENSI instructed the operators of Swiss nuclear power plants to review whether they were relevant to their own facilities. Ageing mechanisms affecting structural materials are crucial to the long-term operation of nuclear power plants. Specialised thematic databases are being created in order to facilitate a systematic analysis of relevant operating experience from numerous countries. In addition to damage that may result from events within nuclear power plants, the safety analyses also reflect external events. ENSI supports international projects conducting complex experiments and simulations of aircraft accidents and earthquakes. It is involved in some projects relating to flood risks. The effect of operator behaviour on accidents in nuclear power plants is the focus point of research into human factors which identifies and analyses certain operator errors influencing negatively the course of an accident. Proposals to improve accident procedures were developed. This research area also focuses on the influence of the control room layout on the performance of operating staff. System behaviour and accident sequences in nuclear power plants are analysed in conditions ranging from normal operations through to accidents resulting in core melt-down. The results are used for the quantitative evaluation of the plant risk in probabilistic safety analyses. Applied research in radiological protection ranges

  3. Research and experience report 2012. Developments in the technical and legal basis of nuclear oversight; Erfahrungs- und Forschungsbericht 2012. Entwicklungen im Bereich der Grundlagen der nuklearen Aufsicht

    NONE

    2013-04-15

    The Swiss Federal Nuclear Safety Inspectorate (ENSI) acts upon the basis of the latest developments in science and technology. ENSI supports and coordinates safety research, the results of which influence directly its Guidelines, individual decisions and resources. Research projects also serve training purposes and maintain competence within ENSI and its experts. The research in fuels and materials covers the reactor core and the graded approach to barriers used for the confinement of radioactive materials. Based on test results from accidents involving a loss of coolant ENSI instructed the operators of Swiss nuclear power plants to review whether they were relevant to their own facilities. Ageing mechanisms affecting structural materials are crucial to the long-term operation of nuclear power plants. Specialised thematic databases are being created in order to facilitate a systematic analysis of relevant operating experience from numerous countries. In addition to damage that may result from events within nuclear power plants, the safety analyses also reflect external events. ENSI supports international projects conducting complex experiments and simulations of aircraft accidents and earthquakes. It is involved in some projects relating to flood risks. The effect of operator behaviour on accidents in nuclear power plants is the focus point of research into human factors which identifies and analyses certain operator errors influencing negatively the course of an accident. Proposals to improve accident procedures were developed. This research area also focuses on the influence of the control room layout on the performance of operating staff. System behaviour and accident sequences in nuclear power plants are analysed in conditions ranging from normal operations through to accidents resulting in core melt-down. The results are used for the quantitative evaluation of the plant risk in probabilistic safety analyses. Applied research in radiological protection ranges

  4. Genetic and biochemical basis of Gall Midge resistance in some cultivars of Indica Rice. Final report for the period 1 October 1980 - 30 November 1986

    Reddy, G.M.

    1986-01-01

    The stability of high productivity of modern rice varieties is greatly affected by insect pests. Rice gall midge is a serious insect pest of rice that is prevalent in several south eastern asian countries. Gall midge resistance has been mainly attributed to antibiosis. No progress has so far been made in identifying the exact biochemical nature of resistance. In Indica subspecies the understanding of chemical nature of disease would be helpful in the control of the disease and also in breeding programme aimed at developing resistance varieties. Studies were undertaken to establish the biochemical basis of resistance. Biochemical characterization of resistant and susceptible varieties were carried out. The parameters considered were: total sugar and reducing sugar content, total phenol content, amino acid profile, post infectional changes in sugar and phenol, isozyme studies. 2 figs, 6 tabs

  5. Genetic and biochemical basis of Gall Midge resistance in some cultivars of Indica Rice. Final report for the period 1 October 1980 - 30 November 1986

    Reddy, G M [Osmania Univ., Hyderabad (India). Dept. of Genetics

    1987-12-31

    The stability of high productivity of modern rice varieties is greatly affected by insect pests. Rice gall midge is a serious insect pest of rice that is prevalent in several south eastern asian countries. Gall midge resistance has been mainly attributed to antibiosis. No progress has so far been made in identifying the exact biochemical nature of resistance. In Indica subspecies the understanding of chemical nature of disease would be helpful in the control of the disease and also in breeding programme aimed at developing resistance varieties. Studies were undertaken to establish the biochemical basis of resistance. Biochemical characterization of resistant and susceptible varieties were carried out. The parameters considered were: total sugar and reducing sugar content, total phenol content, amino acid profile, post infectional changes in sugar and phenol, isozyme studies. 2 figs, 6 tabs.

  6. How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease : a report of the Surgeon General

    2010-01-01

    .... This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke...

  7. Are there safe answers? A report from a seminar on the scientific basis for the disposal of spent nuclear fuel in Sweden, Saltsjoebaden 5-7 september 1989

    Andersson, T.L.

    1990-02-01

    This is a report from a seminar arranged by the Swedish Consultative Committee for Nuclear Waste Management (KASAM). It contains the full text of the papers presented and the discussions at the seminar. (K.A.E.)

  8. EPA Response to the National Research Council (NRC) Report - A Review of the Technical Basis of the Chemical and Pathogen Regulations for Biosolids

    The NRC published two reports over a twenty year span. They concluded that there is no documented scientific evidence that sewage sludge regulations have failed to protect public health, but identified areas of research.

  9. OSR encapsulation basis -- 100-KW

    Meichle, R.H.

    1995-01-01

    The purpose of this report is to provide the basis for a change in the Operations Safety Requirement (OSR) encapsulated fuel storage requirements in the 105 KW fuel storage basin which will permit the handling and storing of encapsulated fuel in canisters which no longer have a water-free space in the top of the canister. The scope of this report is limited to providing the change from the perspective of the safety envelope (bases) of the Safety Analysis Report (SAR) and Operations Safety Requirements (OSR). It does not change the encapsulation process itself

  10. Research and experience report 2010 - Developments in the technical and legal basis of nuclear oversight; Erfahrungs- und Forschungsbericht 2010 - Entwicklungen im Bereich der Grundlagen der nuklearen Aufsicht

    NONE

    2011-04-15

    This comprehensive annual report presents a review of the activities carried out by the Swiss Federal Nuclear Safety Inspectorate (ENSI) in the year 2010. The inspectorate's fields of activity - fuels and materials, significant internal and external events and occurrences, human factors, system behaviour and accident sequences, radiological protection and waste disposal - are reviewed. Information on incidents in Swiss nuclear facilities are reviewed in the ENSI Surveillance Report. The Research and Experience Report also provides information on a selection of particularly instructive incidents in nuclear facilities outside Switzerland. Incidents are analysed with a view to identifying any potential relevance to Swiss nuclear facilities. International co-operation is mentioned and current changes and developments related to plant surveillance are noted. Organisational aspects are discussed and various guidelines and directives are presented and discussed

  11. Research and experience report 2010 - Developments in the technical and legal basis of nuclear oversight; Erfahrungs- und Forschungsbericht 2010 - Entwicklungen im Bereich der Grundlagen der nuklearen Aufsicht

    NONE

    2011-04-15

    This comprehensive annual report presents a review of the activities carried out by the Swiss Federal Nuclear Safety Inspectorate (ENSI) in the year 2010. The inspectorate's fields of activity - fuels and materials, significant internal and external events and occurrences, human factors, system behaviour and accident sequences, radiological protection and waste disposal - are reviewed. Information on incidents in Swiss nuclear facilities are reviewed in the ENSI Surveillance Report. The Research and Experience Report also provides information on a selection of particularly instructive incidents in nuclear facilities outside Switzerland. Incidents are analysed with a view to identifying any potential relevance to Swiss nuclear facilities. International co-operation is mentioned and current changes and developments related to plant surveillance are noted. Organisational aspects are discussed and various guidelines and directives are presented and discussed

  12. Hanford Generic Interim Safety Basis

    Lavender, J.C.

    1994-09-09

    The purpose of this document is to identify WHC programs and requirements that are an integral part of the authorization basis for nuclear facilities that are generic to all WHC-managed facilities. The purpose of these programs is to implement the DOE Orders, as WHC becomes contractually obligated to implement them. The Hanford Generic ISB focuses on the institutional controls and safety requirements identified in DOE Order 5480.23, Nuclear Safety Analysis Reports.

  13. Hanford Generic Interim Safety Basis

    Lavender, J.C.

    1994-01-01

    The purpose of this document is to identify WHC programs and requirements that are an integral part of the authorization basis for nuclear facilities that are generic to all WHC-managed facilities. The purpose of these programs is to implement the DOE Orders, as WHC becomes contractually obligated to implement them. The Hanford Generic ISB focuses on the institutional controls and safety requirements identified in DOE Order 5480.23, Nuclear Safety Analysis Reports

  14. Research and experience report 2007. Developments in the technical and legal basis of nuclear oversight; Erfahrungs- und Forschungsbericht 2007. Entwicklungen im Bereich der Grundlagen der nuklearen Aufsicht

    NONE

    2008-07-01

    This annual report issued by the Swiss Federal Nuclear Inspectorate (HSK) reviews the aims, duties and responsibilities of the inspectorate and the work done during 2007. In the area of reactor safety, the research covered materials and the deterministic and probabilistic analysis of incidents and their consequences. In the area of radiation protection, the protection of persons and the environment in the vicinity of nuclear facilities from ionising radiation is addressed. In this area, accurate metrology and research to improve dosimetry and radiation analysis is discussed. In the area of transport and waste management, the HSK is focussing its efforts on research into the geological strata suitable for the final storage of highly radioactive, long-lived waste. Human factors, organisation and safety culture are quoted as playing a major role in nuclear safety. According to the report, greater attention is being given to these factors by those bodies responsible for nuclear regulation. Appendices present an overview of work done, international activities and publications along with the ENSI's guidelines.

  15. Research and experience report 2007. Developments in the technical and legal basis of nuclear oversight; Erfahrungs- und Forschungsbericht 2007. Entwicklungen im Bereich der Grundlagen der nuklearen Aufsicht

    NONE

    2008-07-01

    This annual report issued by the Swiss Federal Nuclear Inspectorate (HSK) reviews the aims, duties and responsibilities of the inspectorate and the work done during 2007. In the area of reactor safety, the research covered materials and the deterministic and probabilistic analysis of incidents and their consequences. In the area of radiation protection, the protection of persons and the environment in the vicinity of nuclear facilities from ionising radiation is addressed. In this area, accurate metrology and research to improve dosimetry and radiation analysis is discussed. In the area of transport and waste management, the HSK is focussing its efforts on research into the geological strata suitable for the final storage of highly radioactive, long-lived waste. Human factors, organisation and safety culture are quoted as playing a major role in nuclear safety. According to the report, greater attention is being given to these factors by those bodies responsible for nuclear regulation. Appendices present an overview of work done, international activities and publications along with the ENSI's guidelines.

  16. Research and experience report 2008. Developments in the technical and legal basis of nuclear oversight; Erfahrungs- und Forschungsbericht 2008. Entwicklungen im Bereich der Grundlagen der nuklearen Aufsicht

    NONE

    2009-04-15

    This annual report issued by the Swiss Federal Nuclear Inspectorate (ENSI) reviews research into regulatory safety and the work done during 2008. In the area of reactor safety, research - in addition to research into materials - was concentrated primarily on safety and reliability analyses. ENSI supports projects looking at ageing mechanisms such as fatigue, corrosion, embrittlement and the development of cracks under a range of environmental conditions. Topics such as the interaction between core meltdown and water and concrete as well as the development of methods and computer codes are covered. In the area of transport and waste management, ENSI is focussing its efforts on research into the geological strata suitable for the final storage of highly radioactive, long-lived waste. Human and organisational factors and safety culture now account for an increasing part of the work of this regulatory body. Appendices present an overview of work done, international activities, publications and the basic principles of the new ENSI guidelines.

  17. Research and experience report 2015 - Developments in the technical and legal basis for nuclear oversight; Erfahrungs- und Forschungsbericht 2015 - Entwicklungen im Bereich der Grundlagen der nuklearen Aufsicht

    NONE

    2016-04-15

    Projects in the research programme of the Swiss Federal Nuclear Safety Inspectorate (ENSI) contribute to the clarification of outstanding issues, establish fundamentals and develop the tools required for its regulatory activities. International projects deliver results that Switzerland could not achieve on its own and encourage international networking. The research on fuels and materials covers the reactor core and the multiple barriers for the retainment of radioactive materials. In 2015 the OECD Halden Reactor Project developed new methods for measuring the thermal conductivity of fuel and the creep of cladding materials during irradiation in the reactor and ageing processes. The PISA project of the Paul Scherrer Institute (PSI) focused on the deterministic and probabilistic assessment of the integrity of reactor pressure vessels. Under the auspices of the OECD's Nuclear Energy Agency, specific databases are being created on damage to passive metal components and electrical cables. The OECD FIRE project completed its report into the combination of fires with other events; half of these events are linked to electric arcing. ENSI research projects address external events such as earthquakes, flooding, aircraft crashes and explosions. A project of the American Society of Mechanical Engineers is investigating pre-stressed reinforced concrete slabs under explosive loads. Other OECD projects consider the effects of severe earthquakes on reinforced concrete walls and pipelines. The ROES PSI project is expanding the application of methods for assessing operator errors that can negatively influence the course of an accident. System behaviour and accident sequences in nuclear power plants are analysed in conditions ranging from normal operations through to accidents involving core meltdown. The results of computer models are used for the quantitative identification of plant risk in probabilistic safety analyses. The STARS PSI project improves the basic principles for

  18. Cost optimal building performance requirements. Calculation methodology for reporting on national energy performance requirements on the basis of cost optimality within the framework of the EPBD

    Boermans, T.; Bettgenhaeuser, K.; Hermelink, A.; Schimschar, S. [Ecofys, Utrecht (Netherlands)

    2011-05-15

    On the European level, the principles for the requirements for the energy performance of buildings are set by the Energy Performance of Buildings Directive (EPBD). Dating from December 2002, the EPBD has set a common framework from which the individual Member States in the EU developed or adapted their individual national regulations. The EPBD in 2008 and 2009 underwent a recast procedure, with final political agreement having been reached in November 2009. The new Directive was then formally adopted on May 19, 2010. Among other clarifications and new provisions, the EPBD recast introduces a benchmarking mechanism for national energy performance requirements for the purpose of determining cost-optimal levels to be used by Member States for comparing and setting these requirements. The previous EPBD set out a general framework to assess the energy performance of buildings and required Member States to define maximum values for energy delivered to meet the energy demand associated with the standardised use of the building. However it did not contain requirements or guidance related to the ambition level of such requirements. As a consequence, building regulations in the various Member States have been developed by the use of different approaches (influenced by different building traditions, political processes and individual market conditions) and resulted in different ambition levels where in many cases cost optimality principles could justify higher ambitions. The EPBD recast now requests that Member States shall ensure that minimum energy performance requirements for buildings are set 'with a view to achieving cost-optimal levels'. The cost optimum level shall be calculated in accordance with a comparative methodology. The objective of this report is to contribute to the ongoing discussion in Europe around the details of such a methodology by describing possible details on how to calculate cost optimal levels and pointing towards important factors and

  19. Parallel Algorithms for Groebner-Basis Reduction

    1987-09-25

    22209 ELEMENT NO. NO. NO. ACCESSION NO. 11. TITLE (Include Security Classification) * PARALLEL ALGORITHMS FOR GROEBNER -BASIS REDUCTION 12. PERSONAL...All other editions are obsolete. Productivity Engineering in the UNIXt Environment p Parallel Algorithms for Groebner -Basis Reduction Technical Report

  20. From BASIS to MIRACLES

    Tsapatsaris, Nikolaos; Willendrup, Peter Kjær; E. Lechner, Ruep

    2015-01-01

    Results based on virtual instrument models for the first high-flux, high-resolution, spallation based, backscattering spectrometer, BASIS are presented in this paper. These were verified using the Monte Carlo instrument simulation packages McStas and VITESS. Excellent agreement of the neutron count...... are pivotal to the conceptual design of the next generation backscattering spectrometer, MIRACLES at the European Spallation Source....

  1. Intermediate report. Base for the Broad Public Discussion on Energy Policy in the Netherlands. Het tussenrapport. Basis voor de Brede Maatschappelijke Discussie

    1983-01-01

    The Broad Public Djiscussion on Energy Policy (BMD) in the Netherlands is subdivided in an informative and a discussion stage. This intermediate report gives a summary of the first stage. In Ch. 2 the concept of energy and the utilized unities are discussed. Ch. 3 gives information about the actual energy consumption in the world and in the Netherlands and about the varying estimations for the future energy consumption. In Ch. 4 various possibilities for economization of energy in the Netherlands are discussed. Ch. 5 to 7 give the necessary information about the various energy sources. By source respectively the storages, applications, costs, effects on men and environment and public consequences are under discussion. Ch. 8 presents a comparative summary of the advantages and the drawbacks of various energy sources, the estimations for the future use and possibilities for energy economization. Also some attention is paid to the question on which grounds a choice from the policy possibilities may be based. Ch. 9 and 10 deal with the actual energy policy: how it is realized and what it holds. In Ch. 11 the results are discussed of four scenario-studies: how does the future energy consumption look like under different economical circumstances. What could be the effects of this on the environment at different applications of coal, natural gas, nuclear energy etc.. Furthermore the alternatives, which anounce themselves on the ground of the scenario studies, for the future energy policy are discussed. Finally the discussion questions are presented which following the coordination group will be the centre of interest in the second stage of the BMD. 427 refs.; figs.; tabs.

  2. Toward a better understanding of the cellular basis for cerebrospinal fluid shunt obstruction: report on the construction of a bank of explanted hydrocephalus devices.

    Hanak, Brian W; Ross, Emily F; Harris, Carolyn A; Browd, Samuel R; Shain, William

    2016-08-01

    OBJECTIVE Shunt obstruction by cells and/or tissue is the most common cause of shunt failure. Ventricular catheter obstruction alone accounts for more than 50% of shunt failures in pediatric patients. The authors sought to systematically collect explanted ventricular catheters from the Seattle Children's Hospital with a focus on elucidating the cellular mechanisms underlying obstruction. METHODS In the operating room, explanted hardware was placed in 4% paraformaldehyde. Weekly, samples were transferred to buffer solution and stored at 4°C. After consent was obtained for their use, catheters were labeled using cell-specific markers for astrocytes (glial fibrillary acidic protein), microglia (ionized calcium-binding adapter molecule 1), and choroid plexus (transthyretin) in conjunction with a nuclear stain (Hoechst). Catheters were mounted in custom polycarbonate imaging chambers. Three-dimensional, multispectral, spinning-disk confocal microscopy was used to image catheter cerebrospinal fluid-intake holes (10× objective, 499.2-μm-thick z-stack, 2.4-μm step size, Olympus IX81 inverted microscope with motorized stage and charge-coupled device camera). Values are reported as the mean ± standard error of the mean and were compared using a 2-tailed Mann-Whitney U-test. Significance was defined at p imaged to date, resulting in the following observations: 1) Astrocytes and microglia are the dominant cell types bound directly to catheter surfaces; 2) cellular binding to catheters is ubiquitous even if no grossly visible tissue is apparent; and 3) immunohistochemical techniques are of limited utility when a catheter has been exposed to Bugbee wire electrocautery. Statistical analysis of 24 catheters was performed, after excluding 7 catheters exposed to Bugbee wire cautery, 3 that were poorly fixed, and 2 that demonstrated pronounced autofluorescence. This analysis revealed that catheters with a microglia-dominant cellular response tended to be implanted for shorter

  3. Research and experience report 2016 - Developments in the technical and legal basis for nuclear oversight; Erfahrungs- und Forschungsbericht 2016 - Entwicklungen im Bereich der Grundlagen der nuklearen Aufsicht

    NONE

    2017-04-15

    Projects in the research programme of the Swiss Federal Nuclear Safety Inspectorate (ENSI) contribute to the clarification of outstanding issues, establish fundamentals and develop the tools required for its regulatory activities. International projects deliver results that Switzerland could not achieve on its own and encourage cross-border networking. The research on fuels and materials covers the reactor core and the multiple barriers for the retainment of radioactive materials especially concerning high burn-up rates and safety criteria. In 2016, the Studsvik Cladding Integrity Project in Sweden commissioned a new test facility to investigate the behaviour of fuel rods in loss of coolant accidents (LOCA). Research into structural materials focuses on ageing processes. In the NORA project at the Paul Scherrer Institute (PSI), platinum is injected into the cooling system with a view to reducing corrosion. Projects conducted under the auspices of the OECD's Nuclear Energy Agency (NEA) and relating to internal events and damage encourage the international exchange of information on incidents, accidents and component damage. Subject-specific databases are created on incidents involving fires or damage to passive metal components. In 2016 the OECD CODAP project prepared a report on reliability and integrity management in pressurised components. ENSI supports research projects on external events such as earthquakes, flooding, aircraft crashes and explosions. Within the OECD MECOS project, the behaviour of pipes subjected to powerful earthquakes was modelled; it showed improvements in the calculation of cyclic loading and on the limits for simulating elastic-plastic material behaviour under high loads. The impact of operator actions on incidents and accidents is the most important human factor in view of reducing uncertainty in probabilistic safety analyses, as well as the interfaces between humans and technical systems. System behaviour and accident sequences in

  4. Dynamical basis set

    Blanco, M.; Heller, E.J.

    1985-01-01

    A new Cartesian basis set is defined that is suitable for the representation of molecular vibration-rotation bound states. The Cartesian basis functions are superpositions of semiclassical states generated through the use of classical trajectories that conform to the intrinsic dynamics of the molecule. Although semiclassical input is employed, the method becomes ab initio through the standard matrix diagonalization variational method. Special attention is given to classical-quantum correspondences for angular momentum. In particular, it is shown that the use of semiclassical information preferentially leads to angular momentum eigenstates with magnetic quantum number Vertical BarMVertical Bar equal to the total angular momentum J. The present method offers a reliable technique for representing highly excited vibrational-rotational states where perturbation techniques are no longer applicable

  5. Design basis 2

    Larsen, G.; Soerensen, P. [Risoe National Lab., Roskilde (Denmark)

    1996-09-01

    Design Basis Program 2 (DBP2) is comprehensive fully coupled code which has the capability to operate in the time domain as well as in the frequency domain. The code was developed during the period 1991-93 and succeed Design Basis 1, which is a one-blade model presuming stiff tower, transmission system and hub. The package is designed for use on a personal computer and offers a user-friendly environment based on menu-driven editing and control facilities, and with graphics used extensively for the data presentation. Moreover in-data as well as results are dumped on files in Ascii-format. The input data is organized in a in-data base with a structure that easily allows for arbitrary combinations of defined structural components and load cases. (au)

  6. Radioactive Waste Management Basis

    Perkins, B.K.

    2009-01-01

    The purpose of this Radioactive Waste Management Basis is to describe the systematic approach for planning, executing, and evaluating the management of radioactive waste at LLNL. The implementation of this document will ensure that waste management activities at LLNL are conducted in compliance with the requirements of DOE Order 435.1, Radioactive Waste Management, and the Implementation Guide for DOE Manual 435.1-1, Radioactive Waste Management Manual. Technical justification is provided where methods for meeting the requirements of DOE Order 435.1 deviate from the DOE Manual 435.1-1 and Implementation Guide.

  7. What is important for you? A qualitative interview study of living with diabetes and experiences of diabetes care to establish a basis for a tailored Patient-Reported Outcome Measure for the Swedish National Diabetes Register.

    Svedbo Engström, Maria; Leksell, Janeth; Johansson, Unn-Britt; Gudbjörnsdottir, Soffia

    2016-03-24

    There is a growing emphasis on the perspective of individuals living with diabetes and the need for a more person-centred diabetes care. At present, the Swedish National Diabetes Register (NDR) lacks patient-reported outcome measures (PROMs) based on the perspective of the patient. As a basis for a new PROM, the aim of this study was to describe important aspects in life for adult individuals with diabetes. Semistructured qualitative interviews analysed using content analysis. Hospital-based outpatient clinics and primary healthcare clinics in Sweden. 29 adults with type 1 diabetes mellitus (DM) (n=15) and type 2 DM (n=14). Swedish adults (≥ 18 years) living with type 1 DM or type 2 DM (duration ≥ 5 years) able to describe their situation in Swedish. Purposive sampling generated heterogeneous characteristics. To live a good life with diabetes is demanding for the individual, but experienced barriers can be eased by support from others in the personal sphere, and by professional support from diabetes care. Diabetes care was a crucial resource to nurture the individual's ability and knowledge to manage diabetes, and to facilitate life with diabetes by supplying support, guidance, medical treatment and technical devices tailored to individual needs. The analysis resulted in the overarching theme 'To live a good life with diabetes' constituting the two main categories 'How I feel and how things are going with my diabetes' and 'Support from diabetes care in managing diabetes' including five different categories. Common aspects were identified including the experience of living with diabetes and support from diabetes care. These will be used to establish a basis for a tailored PROM for the NDR. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  8. Advanced Fuel Cycle Cost Basis

    D. E. Shropshire; K. A. Williams; W. B. Boore; J. D. Smith; B. W. Dixon; M. Dunzik-Gougar; R. D. Adams; D. Gombert; E. Schneider

    2009-12-01

    This report, commissioned by the U.S. Department of Energy (DOE), provides a comprehensive set of cost data supporting a cost analysis for the relative economic comparison of options for use in the Advanced Fuel Cycle Initiative (AFCI) Program. The report describes the AFCI cost basis development process, reference information on AFCI cost modules, a procedure for estimating fuel cycle costs, economic evaluation guidelines, and a discussion on the integration of cost data into economic computer models. This report contains reference cost data for 25 cost modules—23 fuel cycle cost modules and 2 reactor modules. The cost modules were developed in the areas of natural uranium mining and milling, conversion, enrichment, depleted uranium disposition, fuel fabrication, interim spent fuel storage, reprocessing, waste conditioning, spent nuclear fuel (SNF) packaging, long-term monitored retrievable storage, near surface disposal of low-level waste (LLW), geologic repository and other disposal concepts, and transportation processes for nuclear fuel, LLW, SNF, transuranic, and high-level waste.

  9. Advanced Fuel Cycle Cost Basis

    D. E. Shropshire; K. A. Williams; W. B. Boore; J. D. Smith; B. W. Dixon; M. Dunzik-Gougar; R. D. Adams; D. Gombert

    2007-04-01

    This report, commissioned by the U.S. Department of Energy (DOE), provides a comprehensive set of cost data supporting a cost analysis for the relative economic comparison of options for use in the Advanced Fuel Cycle Initiative (AFCI) Program. The report describes the AFCI cost basis development process, reference information on AFCI cost modules, a procedure for estimating fuel cycle costs, economic evaluation guidelines, and a discussion on the integration of cost data into economic computer models. This report contains reference cost data for 26 cost modules—24 fuel cycle cost modules and 2 reactor modules. The cost modules were developed in the areas of natural uranium mining and milling, conversion, enrichment, depleted uranium disposition, fuel fabrication, interim spent fuel storage, reprocessing, waste conditioning, spent nuclear fuel (SNF) packaging, long-term monitored retrievable storage, near surface disposal of low-level waste (LLW), geologic repository and other disposal concepts, and transportation processes for nuclear fuel, LLW, SNF, and high-level waste.

  10. Advanced Fuel Cycle Cost Basis

    D. E. Shropshire; K. A. Williams; W. B. Boore; J. D. Smith; B. W. Dixon; M. Dunzik-Gougar; R. D. Adams; D. Gombert; E. Schneider

    2008-03-01

    This report, commissioned by the U.S. Department of Energy (DOE), provides a comprehensive set of cost data supporting a cost analysis for the relative economic comparison of options for use in the Advanced Fuel Cycle Initiative (AFCI) Program. The report describes the AFCI cost basis development process, reference information on AFCI cost modules, a procedure for estimating fuel cycle costs, economic evaluation guidelines, and a discussion on the integration of cost data into economic computer models. This report contains reference cost data for 25 cost modules—23 fuel cycle cost modules and 2 reactor modules. The cost modules were developed in the areas of natural uranium mining and milling, conversion, enrichment, depleted uranium disposition, fuel fabrication, interim spent fuel storage, reprocessing, waste conditioning, spent nuclear fuel (SNF) packaging, long-term monitored retrievable storage, near surface disposal of low-level waste (LLW), geologic repository and other disposal concepts, and transportation processes for nuclear fuel, LLW, SNF, transuranic, and high-level waste.

  11. The biological basis of radiotherapy

    Steel, G.G.; Adams, G.E.; Horwich, A.

    1989-01-01

    The focus of this book is the biological basis of radiotherapy. The papers presented include: Temporal stages of radiation action:free radical processes; The molecular basis of radiosensitivity; and Radiation damage to early-reacting normal tissue

  12. Research and experience report 2009. Developments in the technical and legal basis of nuclear oversight; Erfahrungs- und Forschungsbericht 2009. Entwicklungen im Bereich der Grundlagen der nuklearen Aufsicht/Rapport sur la recherche et les experiences en 2009. Developpements dans les bases techniques et legales pour la surveillance nucleaire/Research and experience report 2009. Developments in the technical and legal basis of nuclear oversight

    NONE

    2010-04-15

    physical transport processes and the management of all radioactive waste. ENSI supports research projects into the influence of human behaviour on incident management together with the development of requirement profiles for staff in the control rooms of nuclear power stations. Incidents in nuclear facilities provide concrete data on shortcomings and the potential for improvements in all areas of design and operation. Information on incidents in Swiss nuclear facilities is included in ENSI's (separate) Surveillance Report. Some incidents in nuclear facilities outside Switzerland were analysed in order to identify any relevance for Swiss nuclear facilities. There has been increase worldwide in the number of incidents involving the transport of loads. In Switzerland also, the Interim Storage Facility of Wuerenlingen AG reported an event in 2009 involving a lifting device. ENSI has increased its surveillance of cranes and other lifting devices. The Ringhals nuclear power plant (NPP) in Sweden had been operating at power for 72 days before it was discovered that the automatic initiation of the containment isolation system was not operational: the bypasses in the reactor protection system were not correctly removed. Investigations identified the absence of a clear demarcation between the responsibilities of operating and maintenance personnel. Although very improbable, a similar incident might occur in Switzerland; however it is very likely that it would be picked up during the obligatory functionality check. Nevertheless, ENSI considered it important that facilities took note of this incident. Following heavy rain, debris blocked the cooling water intake at the Cruas 4 NPP; this caused the main water sink to fail. At the Fessenheim 2 NPP, plant residues found their way into the cooling water system after the cleaning system failed. By such an incident in a Swiss NPP, the plant could be made safe because the Swiss NPPs are fed with water from their own wells or from

  13. Basis Document for Sludge Stabilization

    Risenmay, H R

    2001-01-01

    DOE-RL recently issued Safety Evaluation Report (SER) amendments to the PFP Final Safety Analysis Report, HNF-SD-CP-SAR-021 Rev. 2. The Justification for Continued Operations for 2736-ZB and plutonium oxides in BTCs Safety Basis change (letter DOE-RL ABD-074) was approved by one of the SERs. Also approved by SER was the revised accident analysis for Magnesium Hydroxide Precipitation Process (MHPP) gloveboxes HC-230C-3 and HC-230C-5 containing increased glovebox inventories and corresponding increases in seismic release consequence. Numerous implementing documents require revision and issuance to implement the SER approvals. The SER plutonium oxides into BTCs specifically limited the SER scope to ''pure or clean oxides, i.e., 85 wt% or grater Pu, in this feed change'' (SER Section 3.0 Base Information paragraph 4 [page 11]). Comprehensive USQ Evaluation PFP-2001-12 addressed the packaging of Pu alloy metals into BTCs, and the packaging of Pu alloy oxides (powders) into food pack cans and determined that the ac...

  14. Technical basis for tumbleweed survey requirements and disposal criteria

    J. D. Arana

    2000-01-01

    This technical basis document describes the technique for surveying potentially contaminated tumbleweeds in areas where the Environmental Restoration Contractor has jurisdiction and the disposal criteria based on these survey results. The report also discusses the statistical basis for surveys and the historical basis for the assumptions that are used to interpret the surveys

  15. Technical Basis for Tumbleweed Survey Requirements and Disposal Criteria

    Arana, J.D.

    2000-01-01

    This technical basis document describes the technique for surveying potentially contaminated tumbleweeds in areas where the Environmental Restoration Contractor has jurisdiction and the disposal criteria based on these survey results. The report also discusses the statistical basis for surveys and the historical basis for the assumptions that are used to interpret the surveys

  16. Report of 6th research meeting on basic process of fuel cycle for nuclear fusion reactors, Yayoi Research Group; 3rd expert committee on research of nuclear fusion fuel material correlation basis

    NONE

    1996-03-01

    In this report, the lecture materials of Yayoi Research Group, 6th research meeting on basic process of fuel cycle for nuclear fusion reactors which was held at the University of Tokyo on March 25, 1996, are collected. This workshop was held also as 3rd expert committee on research of nuclear fusion fuel material correlation basis of Atomic Energy Society of Japan. This workshop has the character of the preparatory meeting for the session on `Interface effect in nuclear fusion energy system` of the international workshop `Interface effect in quantum energy system`, and 6 lectures and one comment were given. The topics were deuterium transport in Mo under deuterium ion implantation, the change of the stratum structure of graphite by hydrogen ion irradiation, the tritium behavior in opposing materials, the basic studies of the irradiation effects of solid breeding materials, the research on the behavior of hydroxyl group on the surface of solid breeding materials, the sweep gas effect on the surface of solid breeding materials, and the dynamic behavior of ion-implanted deuterium in proton-conductive oxides. (K.I.)

  17. Development of scientific and technological basis for the fabrication of thin film solar cells on the basis of a-Si:H and {mu}c-Si:H using the 'hot-wire' deposition technique. Final report; Entwicklung wissenschaftlicher und technischer Grundlagen fuer die Herstellung von Duennschichtsolarzellen auf der Basis des a-Si:H und {mu}c-Si:H mit der 'Hot-Wire'-Depositionstechnik. Abschlussbericht

    Schroeder, B.

    2002-01-22

    - and p-type emitters have been fabricated. After a very short development time conversion efficiencies have been obtained ({eta}{sub max} = 15.2%) which are reported for PECVD emitters. (orig.) [German] Zwei neue Anlagen zur vollstaendigen bzw. grossflaechigen Abscheidung von a-Si:H basierenden Solarzellen mit der sog. 'Hot-Wire (HW)' CVD wurden aufgebaut. Die Abscheidebedingungen fuer geeignete n- und p-dotierte a-Si:H- bzw. {mu}c-Si:H-Schichten wurden ermittelt. Weltweit wurde erstmals eine a-Si:H-pin-Zelle vollstaendig mit der HWCVD-Methode hergestellt, ein Anfangswirkungsgrad von {eta}{sub initial} = 8,9% wurde erreicht. Nach Entwicklung eines p/n-Tunnel- bzw. Rekombinationsueberganges ist es weltweit ebenfalls erstmals gelungen, pin-pin-Tandemstrukturen mit a-Si:H-Absorbern vollstaendig mit der HWCVD-Methode abzuscheiden. Nach Teilalterung wurden noch Wirkungsgrade von {eta}{approx}7% ermittelt. Generell ist die Stabilitaet der all-HWCVD-Zellen noch unbedriedigend, was auf strukturell instabile p-Schichten zurueckgefuehrt werden konnte. Erste nip-Solarzellen auf Edelstahlsubstraten wurden ebenfalls vollstaendig mit der HWCVD praepariert ({eta}{sub initial}>6%). Der Einbau von {mu}c-Si:H-Absorberschichten die mit HWCVD bzw. ECWR-PECVD hergestellt wurden, in pin-Solarzellen war bisher wenig erfolgreich. In einer Anlage zur grossflaechigen HWCVD-Abscheidung wurden a-Si:H-Schichten mit guter Qualitaet und einer Schichtdickenuniformitaet von {delta}d = {+-}2,5% hergestellt. Fuer sog. 'Huepfzellen', nur die i-Schicht wurde in der Anlage abgeschieden, wurden auch sehr uniforme Anfangswirkungsgrade {eta}{sub initial}=6,1{+-}0,2% fuer kleinflaechige Zellen auf einer Flaeche von 20 x 20 cm{sup 2} erreicht. Diese Ergebnisse koennen als 'proof of concept' fuer die grossflaechige HWCVD-Abscheidung fuer a-Si:H-basierende Solarzellen betrachtet werden. Erstmals wurde die HWCVD zur Abscheidung von Emitter-Schichten fuer Hetero-Solarzellen auf c-Si-Wafer-Basis

  18. Annual report on the activities of National Reference Centers established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic in 2009

    2010-01-01

    A brief account of activities carried out by the National Reference Centers (NRC) established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic in 2009 is presented. These activities are reported under the headings: (1) NRC for influenza; (2) NRC for arbovirus and hemorrhagic fever; (3) NRC for poliomyelitis; (4) NRC for meningococci; (5) NRC to monitor the resistance of microorganisms to antibiotics; (6) NRC for evaluation of late effects of chemical substances, methods of genetic toxicology; (7) NRC for hydrobiology; (8) NRC for ecotoxicology; (9) NRC for non-ionizing radiation; (10) NRC for hydrothermal microclimate; (11) NRC for exposure tests xenobiotics; (12) NRC for morbilli, rubella and parotitis; (13) NRC for environmental microbiology; (14) NRC on pesticide residues; (15) NRC for salmonella; (16) NRC health issues for urban air pollution; (17) NRC for microbial autovaccines; (18) NRC for noise and vibration; (19) Information Center for bacteriological (biological) and toxin weapons; (20) NRC for impact assessment of ambient air and air of enclosed spaces non-productive nature of population health; (21) NRC for toxoplasmosis; (22) NRC for exposure assessment and health risk; (23) NRC for pertussis and parapertussis; (24) NRC for syphilis; (25) NRC for hygienic drinking water problems; (26) NRC for listeriosis; (27) NRC for intestinal parasitosis; (28) NRC for diphtheria; (29) NRC for vibrionaceae; (30) NRC for environmental mycology; (31) NRC issues for fibrous dusts; (32) NRC for thermotolerant amoebae; (33) NRC issues for coal mines; (34) NRC for articles of daily use and packing materials; (35) NRC for haemophilus infections; (36) NRC for Legionella in the environment.

  19. Annual report on the activities of National Reference Centers established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic in 2008

    2009-02-01

    A brief account of activities carried out by the National Reference Centers (NRC) established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic in 2008 is presented. These activities are reported under the headings: (1) NRC for influenza; (2) NRC for arbovirus and hemorrhagic fever; (3) NRC for poliomyelitis; (4) NRC for meningococci; (5) NRC to monitor the resistance of microorganisms to antibiotics; (6) NRC for evaluation of late effects of chemical substances, methods of genetic toxicology; (7) NRC for hydrobiology; (8) NRC for ecotoxicology; (9) NRC for non-ionizing radiation; (10) NRC for hydrothermal microclimate; (11) NRC for exposure tests xenobiotics; (12) NRC for morbilli, rubella and parotitis; (13) NRC for environmental microbiology; (14) NRC on pesticide residues; (15) NRC for salmonella; (16) NRC for microbial autovaccines; (17) NRC health issues for urban air pollution; (18) NRC for noise and vibration; (19) Information Center for bacteriological (biological) and toxin weapons; (20) NRC for impact assessment of ambient air and air of enclosed spaces non-productive nature of population health; (21) NRC for toxoplasmosis; (22) NRC for exposure assessment and health risk; (23) NRC for pertussis and parapertussis; (24) NRC for syphilis; (25) NRC for hygienic drinking water problems; (26) NRC for listeriosis; (27) NRC for intestinal parasitosis; (28) NRC for diphtheria; (29) NRC for vibrionaceae; (30) NRC for environmental mycology; (31) NRC issues for fibrous dusts; (32) NRC for thermotolerant amoebae; (33) NRC issues for coal mines; (34) NRC for packaging materials; (35) NRC for haemophilus infections; (36) NRC for Legionella.

  20. Annual report of the National Reference Centres established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic. Year 2010

    2011-02-01

    A brief account of activities carried out by the National Reference Centres (NRC) established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic. (UVZ SR) in 2010 is presented. These activities are reported under the headings: (1) NRC for flu; (2) NRC for arbovirus and hemorrhagic fever; (3) NRC for poliomyelitis; (4) NRC for meningococci; (5) NRC to monitor the resistance of microorganisms to antibiotics; (6) NRC for morbilli, rubella and parotitis; (7) NRC for salmonellosis; (8) NRC for evaluation of late effects of chemicals by methods of genetic toxicology; (9) NRC for hydrobiology; (10) NRC for ecotoxicology; (11) NRC for non-ionizing radiation; (12) NRC for hydrothermal microclimate; (13) NRC tests for exposure of xenobiotics; (14) NRC for environmental microbiology; (15) NRC for Legionella in the environment; (16) NRC on pesticide residues; (17) The Information Centre for bacteriological (biological) and toxin weapons; (18) NRC for impact assessment of ambient air pollution and an enclosed non-productive nature of the health of the population; (19) NRC for toxoplasmosis; (20) NRC Assessment of personal exposure and health risk; (21) NRC for pertussis and parapertussis; (22) NRC for syphilis; (23) NRC for hygienic drinking water problems; (24) NRC for listeriosis; (25) NRC for intestinal parasites; (26) NRC for diphtheria; (27) NRC for coagulase-positive staphylococci and their toxins; (28) NRC for Vibrionaceae; (29) NRC for environmental mycology; (30) NRC for noise and vibration; (31) NRC for health issues fibrous dusts; (32) NRC for thermotolerant amoebae; (33) NRC issues for coal mines; (34) NRC for materials in contact with food; (35) NRC for haemophilus infection; (36) Dedicated site for viral hepatitis.

  1. Annual report of the National Reference Centres established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic. Year 2011

    2012-02-01

    A brief account of activities carried out by the National Reference Centres (NRC) established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic. (UVZ SR) in 2011 is presented. These activities are reported under the headings: (1) NRC for flu; (2) NRC for arbovirus and hemorrhagic fever; (3) NRC for poliomyelitis; (4) NRC for meningococci; (5) NRC to monitor the resistance of microorganisms to antibiotics; (6) NRC for morbilli, rubella and parotitis; (7) NRC for salmonellosis; (8) NRC for evaluation of late effects of chemicals by methods of genetic toxicology; (9) NRC for hydrobiology; (10) NRC for ecotoxicology; (11) NRC for non-ionizing radiation; (12) NRC for hydrothermal microclimate; (13) NRC tests for exposure of xenobiotics; (14) NRC for environmental microbiology; (15) NRC for Legionella in the environment; (16) NRC on pesticide residues; (17) The Information Centre for bacteriological (biological) and toxin weapons; (18) NRC for impact assessment of ambient air pollution and an enclosed non-productive nature of the health of the population; (19) NRC for toxoplasmosis; (20) NRC Assessment of personal exposure and health risk; (21) NRC for pertussis and parapertussis; (22) NRC for pneumococcal infection; (23) NRC for syphilis; (24) NRC for hygienic drinking water problems; (25) NRC for listeriosis; (26) NRC for intestinal parasites; (27) NRC for diphtheria; (28) NRC for coagulase-positive staphylococci and their toxins; (29) NRC for Vibrionaceae; (30) NRC for environmental mycology; (31) NRC for noise and vibration; (32) NRC for commonly used items and packaging materials; (33) NRC for thermotolerant amoebae; (34) NRC issues for coal mines; (35) NRC for work physiology and ergonomics; (37) NRC for health issues fibrous dusts; (38) NRC for haemophilus infection.

  2. Annual report of the National Reference Centres established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic. Year 2012

    2013-02-01

    A brief account of activities carried out by the National Reference Centres (NRC) established on the basis of regional public health authorities of the Slovak Republic and the Office of Public Health of the Slovak Republic. (UVZ SR) in 2012 is presented. These activities are reported under the headings: (1) NRC for flu; (2) NRC for arbovirus and hemorrhagic fever; (3) NRC for poliomyelitis; (4) NRC for meningococci; (5) NRC to monitor the resistance of microorganisms to antibiotics; (6) NRC for morbilli, rubella and parotitis; (7) NRC for salmonellosis; (8) NRC for evaluation of late effects of chemicals by methods of genetic toxicology; (9) NRC for hydrobiology; (10) NRC for ecotoxicology; (11) NRC for non-ionizing radiation; (12) NRC for hydrothermal microclimate; (13) NRC tests for exposure of xenobiotics; (14) NRC for environmental microbiology; (15) NRC for Legionella in the environment; (16) NRC on pesticide residues; (17) NRC for impact assessment of ambient air pollution and an enclosed non-productive nature of the health of the population; (18) NRC for toxoplasmosis; (19) NRC Assessment of personal exposure and health risk; (20) NRC for pertussis and parapertussis; (21) NRC for pneumococcal disease; (22) NRC for syphilis; (23) NRC for hygienic drinking water problems; (24) NRC for listeriosis; (25) The National Information Centre for bacteriological (biological) and toxin weapons; (26) NRC for intestinal parasites; (27) NRC for diphtheria; (28) NRC for coagulase-positive staphylococci and their toxins; (29) NRC for Vibrionaceae; (30) NRC for environmental mycology; (31) NRC for noise and vibration; (32) NRC for articles of daily use and packaging materials; (33) NRC for thermotolerant amoebae; (34) NRC issues for coal mines; (35) NRC to work physiology and ergonomics; (36) NRC for health issues fibrous dusts; (37) NRC for haemophilus infection; (38) NRC for cosmetic products.

  3. REFORMASI SISTEM AKUNTANSI CASH BASIS MENUJU SISTEM AKUNTANSI ACCRUAL BASIS

    Yuri Rahayu

    2016-03-01

    Full Text Available Abstract –  Accounting reform movement was born with the aim of structuring the direction of improvement . This movement is characterized by the enactment of the Act of 2003 and Act 1 of 2004, which became the basis of the birth of Government Regulation No.24 of 2005 on Government Accounting Standards ( SAP . The general,  accounting is based on two systems,  the cash basis  and the accrual basis. The facts speak far students still at problem with differences to the two methods that result in a lack of understanding on the treatment system for recording. The purpose method of research is particularly relevant to student references who are learning basic accounting so that it can provide information and more meaningful understanding of the accounting method cash basis and Accrual basis. This research was conducted through a normative approach, by tracing the document that references a study/library that combines source of reference that can be believed either from books and the internet are processed with a foundation of knowledge and experience of the author. The conclusion can be drawn that basically to be able to understand the difference of the system and the Cash Basis accrual student base treatment requires an understanding of both methods. To be able to have the ability and understanding of both systems required reading exercises and reference sources.   Keywords : Reform, cash basis, accrual basis   Abstrak - Gerakan reformasi akuntansi dilahirkan dengan tujuan penataan ke arah perbaikan. Gerakan ini  ditandai dengan dikeluarkannya  Undang-Undang tahun 2003 dan Undang-Undang No.1 Tahun 2004  yang menjadi dasar lahirnya Peraturan Pemerintah No.24 Tahun 2005 tentang Standar Akuntansi Pemerintah (SAP . Pada umumnya pencatatan akuntansi di dasarkan pada dua sistem yaitu basis kas (Cash Basis dan basis akrual  (Accrual Basis. Fakta berbicara Selama ini mahasiswa masih dibinggungkan dengan perbedaan ke dua metode itu sehingga

  4. Regionalisation of the recent and potential future climate of Central Asia. Modelling on the basis of direct climate data. Final report; Regionalisierung der rezenten und potentiell-zukuenftigen Klimaverhaeltnisse Zentralasiens. Modellierung auf Basis von direkten Klimadaten, geomorphologisch-palaeooekologischen Befunden und GCM-Simulationen. Schlussbericht

    Boehner, J; Haselein, F; Hoffmann, H; Klinge, M; Lehmkuhl, F

    2001-07-01

    During the research project, the scientific base for the methodological coupling of GCM-Simulations and relief parametrisations for a spatially distributed downscaling scheme and for the detection of climatic controlled geomorphologic process regions was founded. The results of the application of the downscaling procedure and the detected climatic determinants of the recent geomorphologic process regions serve as the actualistic base for a proxy based climatic reconstruction as well as for the prognosis of potential future climatic impacts on the environment of Central and High Mountain Asia. For the Last Glacial Maximum (LGM), the spatial distribution of temperature and precipitation of Central- and High Mountain Asia was reconstructed and compared to the downscaling results of GCM-Paleo simulations (ECHAM). Due to the possibility of a direct parameterisation of GCM generated circulation variables and complex relief parameters for the regionalisation of climatic variables and geomorphologic process regions, the validation of ECHAM paleo simulations was also possible by comparing the proxy based reconstruction of the late quaternary environment to the modelled environment as derived from the application of ECHAM LGM simulations. For the assessment of potential future climatic impacts on the natural environment, alternative SRES emission scenarios are taken into account to detect the range of possible future changes in the distribution of Central Asia mountain belts and climatic controlled geomorphologic process regions. (orig.) [German] Im Rahmen des Forschungsprojektes wurden die Grundlagen zur methodisch-konzeptionellen Koppelung von GCM-Simulationen mit Reliefparametrisierungen zur raeumlich hochaufloesenden Klimaregionalisierung sowie zur Erfassung und quantitativen Eingrenzung klimatisch determinierter Prozessregionen geschaffen, die die aktualistische Basis fuer Klimarekonstruktionen auf Basis von Proxies aber auch die Grundlage fuer geomorphologisch

  5. BWR NSSS design basis documentation

    Vij, R.S.; Bates, R.E.

    2004-01-01

    In 1985 an incident at Toledo Edison's Davis Besse plant caused the U.S. Nuclear Regulatory Commission (NRC) to re-evaluate the technical information that the utilities had readily available to support the design of their plants. The Design Basis programs, currently on going in most U.S. utilities, have been the nuclear industry's response to the needs identified by this re-evaluation. In order to understand the Design Basis programs which have been implemented by the U.S. nuclear utilities, it is necessary to understand the problem as it was perceived by the nuclear industry (the utilities, the original NSSS designers and the regulators) after the Davis-Besse incident, the subsequent programs undertaken by the industry under the leadership of INPO and NUMARC, the NRC's actions, and the overall evolution of the industry's vision in relation to this problem. This paper presents the history of the design basis efforts from the first recognition of the problem by the NRC after the Davis-Besse incident, describes the actions taken by the NRC, INPO, NUMARC, the U.S. utilities and the NSSS designers, and brings the problem statement up-to-date in relation to the vision presently held by the U.S. nuclear industry. It then presents a technical discussion to develop a detailed definition of design basis information to support the problem statement. The information originally supplied by the NSSS designers during the plant design and construction is discussed as well as its relationship to the previously defined design basis information. This section of the paper concludes by defining the additional information needed by nuclear utilities to satisfy the requirements developed from the problem statement. Having developed a definition of the additional information (i.e., information not originally supplied during design and construction) required to solve the design basis problem as it is presently perceived by the U.S. nuclear industry, the paper then discusses design basis

  6. Genetic basis of chronic pancreatitis

    Jansen, JBMJ; Morsche, RT; van Goor, Harry; Drenth, JPH

    2002-01-01

    Background: Pancreatitis has a proven genetic basis in a minority of patients. Methods: Review of the literature on genetics of pancreatitis. Results: Ever since the discovery that in most patients with hereditary pancreatitis a mutation in the gene encoding for cationic trypsinogen (R122H) was

  7. Ellipsoidal basis for isotropic oscillator

    Kallies, W.; Lukac, I.; Pogosyan, G.S.; Sisakyan, A.N.

    1994-01-01

    The solutions of the Schroedinger equation are derived for the isotropic oscillator potential in the ellipsoidal coordinate system. The explicit expression is obtained for the ellipsoidal integrals of motion through the components of the orbital moment and Demkov's tensor. The explicit form of the ellipsoidal basis is given for the lowest quantum numbers. 10 refs.; 1 tab. (author)

  8. Molecular basis of familial hypercholesterolemia

    Bruikman, Caroline S.; Hovingh, Gerard K.; Kastelein, John J. P.

    2017-01-01

    Purpose of review To provide an overview about the molecular basis of familial hypercholesterolemia. Recent findings Familial hypercholesterolemia is a common hereditary cause of premature coronary heart disease. It has been estimated that 1 in every 250 individuals has heterozygous familial

  9. Basis reduction for layered lattices

    E.L. Torreão Dassen (Erwin)

    2011-01-01

    htmlabstractWe develop the theory of layered Euclidean spaces and layered lattices. With this new theory certain problems that usually are solved by using classical lattices with a "weighting" gain a new, more natural form. Using the layered lattice basis reduction algorithms introduced here these

  10. Mixtures of truncated basis functions

    Langseth, Helge; Nielsen, Thomas Dyhre; Rumí, Rafael

    2012-01-01

    In this paper we propose a framework, called mixtures of truncated basis functions (MoTBFs), for representing general hybrid Bayesian networks. The proposed framework generalizes both the mixture of truncated exponentials (MTEs) framework and the mixture of polynomials (MoPs) framework. Similar t...

  11. Technical basis document for natural event hazards

    CARSON, D.M.

    2003-01-01

    This technical basis document was developed to support the Tank Farms Documented Safety Analysis (DSA), and describes the risk binning process and the technical basis for assigning risk bins for natural event hazards (NEH)-initiated representative accident and associated represented hazardous conditions. The purpose of the risk binning process is to determine the need for safety-significant structures, systems, and components (SSC) and technical safety requirement (TSR)-level controls for a given representative accident or represented hazardous conditions based on an evaluation of the frequency and consequence. Note that the risk binning process is not applied to facility workers, because all facility worker hazardous conditions are considered for safety-significant SSCs and/or TSR-level controls. Determination of the need for safety-class SSCs was performed in accordance with DOE-STD-3009-94, ''Preparation Guide for US Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses'', as described in this report

  12. Theoretical basis for graphite stress analysis in BERSAFE

    Harper, P.G.

    1980-03-01

    The BERSAFE finite element computer program for structural analysis has been extended to deal with structures made from irradiated graphite. This report describes the material behaviour which has been modelled and gives the theoretical basis for the solution procedure. (author)

  13. Quantitative compositional analysis and field-evaporation behavior of ordered Ni4Mo on an atomic plane-by-plane basis: an atom-probe field-ion microscope study. MSC report No. 4802

    Yamamoto, M.; Seidman, D.N.

    1982-10-01

    The (211) fundamental and (101) superlattice planes, of the bct lattice, were analysed chemically on an atomic plane-by-plane basis. It was demonstrated that the composition of each individual plane can be determined as a function of depth without any ambiguity. The overall average Mo concentration was measured to be 17.1 at. % for the (211) fundamental plane. Details of the field evaporation behavior of the (211) fundamental and (101) superlattice planes were studied. The field-evaporation behavior is described in terms of the field-evaporation rate, the order of the field evaporated ions, etc. Each individual atomic plane field evaporated on an atomic plane-by-plane basis for the (211) fundamental plane. While for (101) superlattice plane a group of planes consisting of one plane of Mo atoms and four planes of Ni atoms field-evaporated as a unit. An abnormal increase in the number of Mo atoms was found in the central portion of the (211) fundamental plane. Possible mechanisms for the abnormal field evaporation rate are discussed. It is concluded that the atom probe technique can be used to follow the physics and chemistry of the field-evaporation process and the chemistry of the alloy as a function of position, on a subnanometer scale, throughout the specimen. 13 figures

  14. Probing community nurses' professional basis

    Schaarup, Clara; Pape-Haugaard, Louise; Jensen, Merete Hartun

    2017-01-01

    Complicated and long-lasting wound care of diabetic foot ulcers are moving from specialists in wound care at hospitals towards community nurses without specialist diabetic foot ulcer wound care knowledge. The aim of the study is to elucidate community nurses' professional basis for treating...... diabetic foot ulcers. A situational case study design was adopted in an archetypical Danish community nursing setting. Experience is a crucial component in the community nurses' professional basis for treating diabetic foot ulcers. Peer-to-peer training is the prevailing way to learn about diabetic foot...... ulcer, however, this contributes to the risk of low evidence-based practice. Finally, a frequent behaviour among the community nurses is to consult colleagues before treating the diabetic foot ulcers....

  15. Intracellular recovery - basis of hyperfractionation

    Hagen, U.; Guttenberger, R.; Kummermehr, J.

    1988-01-01

    The radiobiological basis fo a hyperfractionated radiation therapy versus conventional fractionation with respect to therapeutic gain, i.e., improved normal tissue sparing for the same level of tumour cell inactivation, will be presented. Data on the recovery potential of various tissues as well as the kinetics of repair will be given. The problem of incomplete repair with short irradiation intervals will be discussed. (orig.) [de

  16. Canister storage building design basis accident analysis documentation

    KOPELIC, S.D.

    1999-01-01

    This document provides the detailed accident analysis to support HNF-3553, Spent Nuclear Fuel Project Final Safety Analysis Report, Annex A, ''Canister Storage Building Final Safety Analysis Report.'' All assumptions, parameters, and models used to provide the analysis of the design basis accidents are documented to support the conclusions in the Canister Storage Building Final Safety Analysis Report

  17. Canister storage building design basis accident analysis documentation

    KOPELIC, S.D.

    1999-02-25

    This document provides the detailed accident analysis to support HNF-3553, Spent Nuclear Fuel Project Final Safety Analysis Report, Annex A, ''Canister Storage Building Final Safety Analysis Report.'' All assumptions, parameters, and models used to provide the analysis of the design basis accidents are documented to support the conclusions in the Canister Storage Building Final Safety Analysis Report.

  18. Canister Storage Building (CSB) Design Basis Accident Analysis Documentation

    CROWE, R.D.

    1999-01-01

    This document provides the detailed accident analysis to support ''HNF-3553, Spent Nuclear Fuel Project Final Safety, Analysis Report, Annex A,'' ''Canister Storage Building Final Safety Analysis Report.'' All assumptions, parameters, and models used to provide the analysis of the design basis accidents are documented to support the conclusions in the Canister Storage Building Final Safety Analysis Report

  19. Canister Storage Building (CSB) Design Basis Accident Analysis Documentation

    CROWE, R.D.; PIEPHO, M.G.

    2000-01-01

    This document provided the detailed accident analysis to support HNF-3553, Spent Nuclear Fuel Project Final Safety Analysis Report, Annex A, ''Canister Storage Building Final Safety Analysis Report''. All assumptions, parameters, and models used to provide the analysis of the design basis accidents are documented to support the conclusions in the Canister Storage Building Final Safety Analysis Report

  20. Genetic basis of atrial fibrillation

    Oscar Campuzano

    2016-12-01

    Full Text Available Atrial fibrillation is the most common sustained arrhythmia and remains as one of main challenges in current clinical practice. The disease may be induced secondary to other diseases such as hypertension, valvular heart disease, and heart failure, conferring an increased risk of stroke and sudden death. Epidemiological studies have provided evidence that genetic factors play an important role and up to 30% of clinically diagnosed patients may have a family history of atrial fibrillation. To date, several rare variants have been identified in a wide range of genes associated with ionic channels, calcium handling protein, fibrosis, conduction and inflammation. Important advances in clinical, genetic and molecular basis have been performed over the last decade, improving diagnosis and treatment. However, the genetics of atrial fibrillation is complex and pathophysiological data remains still unraveling. A better understanding of the genetic basis will induce accurate risk stratification and personalized clinical treatment. In this review, we have focused on current genetics basis of atrial fibrillation.

  1. 340 Waste Handling Facility interim safety basis

    Bendixsen, R.B.

    1995-01-01

    This document establishes the interim safety basis (ISB) for the 340 Waste Handling Facility (340 Facility). An ISB is a documented safety basis that provides a justification for the continued operation of the facility until an upgraded final safety analysis report is prepared that complies with US Department of Energy (DOE) Order 5480.23, Nuclear Safety Analysis Reports. The ISB for the 340 Facility documents the current design and operation of the facility. The 340 Facility ISB (ISB-003) is based on a facility walkdown and review of the design and operation of the facility, as described in the existing safety documentation. The safety documents reviewed, to develop ISB-003, include the following: OSD-SW-153-0001, Operating Specification Document for the 340 Waste Handling Facility (WHC 1990); OSR-SW-152-00003, Operating Limits for the 340 Waste Handling Facility (WHC 1989); SD-RE-SAP-013, Safety Analysis Report for Packaging, Railroad Liquid Waste Tank Cars (Mercado 1993); SD-WM-TM-001, Safety Assessment Document for the 340 Waste Handling Facility (Berneski 1994a); SD-WM-SEL-016, 340 Facility Safety Equipment List (Berneski 1992); and 340 Complex Fire Hazard Analysis, Draft (Hughes Assoc. Inc. 1994)

  2. Technical basis for internal dosimetry at Hanford

    Sula, M.J.; Carbaugh, E.H.; Bihl, D.E.

    1991-07-01

    The Hanford Internal Dosimetry Program, administered by Pacific Northwest Laboratory for the US Department of Energy, provides routine bioassay monitoring for employees who are potentially exposed to radionuclides in the workplace. This report presents the technical basis for routine bioassay monitoring and the assessment of internal dose at Hanford. The radionuclides of concern include tritium, corrosion products ( 58 Co, 60 Co, 54 Mn, and 59 Fe), strontium, cesium, iodine, europium, uranium, plutonium, and americium,. Sections on each of these radionuclides discuss the sources and characteristics; dosimetry; bioassay measurements and monitoring; dose measurement, assessment, and mitigation and bioassay follow-up treatment. 78 refs., 35 figs., 115 tabs

  3. Technical basis for internal dosimetry at Hanford

    Sula, M.J.; Carbaugh, E.H.; Bihl, D.E.

    1991-07-01

    The Hanford Internal Dosimetry Program, administered by Pacific Northwest Laboratory for the US Department of Energy, provides routine bioassay monitoring for employees who are potentially exposed to radionuclides in the workplace. This report presents the technical basis for routine bioassay monitoring and the assessment of internal dose at Hanford. The radionuclides of concern include tritium, corrosion products ({sup 58}Co, {sup 60}Co, {sup 54}Mn, and {sup 59}Fe), strontium, cesium, iodine, europium, uranium, plutonium, and americium,. Sections on each of these radionuclides discuss the sources and characteristics; dosimetry; bioassay measurements and monitoring; dose measurement, assessment, and mitigation and bioassay follow-up treatment. 78 refs., 35 figs., 115 tabs.

  4. Technical basis for internal dosimetry at Hanford

    Sula, M.J.; Carbaugh, E.H.; Bihl, D.E.

    1989-04-01

    The Hanford Internal Dosimetry Program, administered by Pacific Northwest Laboratory for the US Department of Energy, provides routine bioassay monitoring for employees who are potentially exposed to radionuclides in the workplace. This report presents the technical basis for routine bioassay monitoring and the assessment of internal dose at Hanford. The radionuclides of concern include tritium, corrosion products (/sup 58/Co, /sup 60/Co, /sup 54/Mn, and /sup 59/Fe), strontium, cesium, iodine, europium, uranium, plutonium, and americium. Sections on each of these radionuclides discuss the sources and characteristics; dosimetry; bioassay measurements and monitoring; dose measurement, assessment, and mitigation; and bioassay follow-up treatment. 64 refs., 42 figs., 118 tabs.

  5. Technical basis for internal dosimetry at Hanford

    Sula, M.J.; Carbaugh, E.H.; Bihl, D.E.

    1989-04-01

    The Hanford Internal Dosimetry Program, administered by Pacific Northwest Laboratory for the US Department of Energy, provides routine bioassay monitoring for employees who are potentially exposed to radionuclides in the workplace. This report presents the technical basis for routine bioassay monitoring and the assessment of internal dose at Hanford. The radionuclides of concern include tritium, corrosion products ( 58 Co, 60 Co, 54 Mn, and 59 Fe), strontium, cesium, iodine, europium, uranium, plutonium, and americium. Sections on each of these radionuclides discuss the sources and characteristics; dosimetry; bioassay measurements and monitoring; dose measurement, assessment, and mitigation; and bioassay follow-up treatment. 64 refs., 42 figs., 118 tabs

  6. UP-report. Energy systems studies. Basis of the Development platform. System to the Swedish Energy Agency's strategy work FOKUS; UP-rapport. Energisystemstudier. Underlag fraan Utvecklingsplattformen. System till Energimyndighetens strategiarbete FOKUS

    Ingelstam, Lars; Alm, Maria

    2012-11-01

    The report serves as input to the Swedish Energy Agency's strategies and priorities for research and innovation in the thematic area Energy systems studies for the period 2011 - 2016. The report has been compiled by members of the the Development platform System. This report provides background and circumstances for the energy system studies theme, and proposed priorities and activities for future efforts in this area. The development platform has contributed with valuable experience and knowledge that enabled the Swedish Energy Agency to then develop a strategy that meets the needs of society and business.

  7. UP-report. Buildings in the energy system. Basis of the Development platform. Build to the Swedish Energy Agency's strategy work FOKUS; UP-rapport. Byggnader i energisystemet. Underlag fraan Utvecklingsplattformen. Bygg till Energimyndighetens strategiarbete FOKUS

    NONE

    2012-11-01

    The report serves as input to the Swedish Energy Agency's strategies and priorities for research and innovation in the thematic area buildings in the energy system for the period 2011 - 2016. The report has been compiled by members of the development platform Build. This report provides background and the conditions of the area buildings in the energy system, and proposed priorities and activities for future efforts in this area. The development platform has contributed with valuable experience and knowledge which enabled the Swedish Energy Agency to then develop a strategy that meets the needs of the society and business.

  8. UP-report. Energy intensive industry. Basis of the Development platform. Industry to the Swedish Energy Agency's strategy work FOKUS; UP-rapport. Energiintensiv industri. Underlag fraan Utvecklingsplattformen. Industri till Energimyndighetens strategiarbete FOKUS

    NONE

    2012-11-01

    The report serves as input to the Swedish Energy Agency's strategies and priorities for research and innovation under the thematic area of energy intensive industry for the period 2011 - 2016. The report has been compiled by members of the Development platform Industry. This report provides background and conditions for the energy intensive industry, and proposed priorities and activities for future efforts in this area. The development platform has contributed with valuable experience and knowledge which enabled the Swedish Energy Agency to then develop a strategy that meets needs of the society and business.

  9. UP-report. Fuel-based energy systems. Basis of the Development platform. Fuel to the Swedish Energy Agency's strategy work FOKUS; UP-rapport. Braenslebaserade energisystem. Underlag fraan Utvecklingsplattformen. Braensle till Energimyndighetens strategiarbete FOKUS

    NONE

    2012-11-01

    The report serves as input to the Swedish Energy Agency's strategies and priorities for research and innovation in the fuel-based energy system for the period 2011 - 2016. The report has been compiled by members of the development platform Fuel. This report provides background and conditions for the fuel based energy system, and proposed priorities and activities for future efforts in this area. The development platform has contributed with valuable experience and knowledge which enabled the Swedish Energy Agency to then develop a strategy that meets the needs of the society and business.

  10. UP-report. The power system. Basis of the Development platform. Power to Swedish Energy Agency's strategy work FOKUS; UP-rapport. Kraftsystemet. Underlag fraan Utvecklingsplattformen. Kraft till Energimyndighetens strategiarbete FOKUS

    NONE

    2012-11-01

    The report serves as input to to Swedish Energy Agency's strategies and priorities for research and innovation in the power system for the period 2011 - 2016. The report has been compiled by members of the development platform Kraft. This report provides background and circumstances for the power system theme, and proposed priorities and activities for future efforts in this area. The development platform has contributed with valuable experience and skills that enabled the Swedish Energy Agency to then develop a strategy that meets the needs of society and business.

  11. Thermodynamic basis for cluster kinetics

    Hu, Lina; Bian, Xiufang; Qin, Xubo

    2006-01-01

    Due to the inaccessibility of the supercooled region of marginal metallic glasses (MMGs) within the experimental time window, we study the cluster kinetics above the liquidus temperature, Tl, to acquire information on the fragility of the MMG systems. Thermodynamic basis for the stability...... of locally ordered structure in the MMG liquids is discussed in terms of the two-order-parameter model. It is found that the Arrhenius activation energy of clusters, h, is proportional to the chemical mixing enthalpy of alloys, Hchem. Fragility of the MMG forming liquids can be described by the ratio...

  12. The physical basis of chemistry

    Warren, Warren S

    2000-01-01

    If the text you're using for general chemistry seems to lack sufficient mathematics and physics in its presentation of classical mechanics, molecular structure, and statistics, this complementary science series title may be just what you're looking for. Written for the advanced lower-division undergraduate chemistry course, The Physical Basis of Chemistry, Second Edition, offers students an opportunity to understand and enrich the understanding of physical chemistry with some quantum mechanics, the Boltzmann distribution, and spectroscopy. Posed and answered are questions concerning eve

  13. Quadratic Hedging of Basis Risk

    Hardy Hulley

    2015-02-01

    Full Text Available This paper examines a simple basis risk model based on correlated geometric Brownian motions. We apply quadratic criteria to minimize basis risk and hedge in an optimal manner. Initially, we derive the Föllmer–Schweizer decomposition for a European claim. This allows pricing and hedging under the minimal martingale measure, corresponding to the local risk-minimizing strategy. Furthermore, since the mean-variance tradeoff process is deterministic in our setup, the minimal martingale- and variance-optimal martingale measures coincide. Consequently, the mean-variance optimal strategy is easily constructed. Simple pricing and hedging formulae for put and call options are derived in terms of the Black–Scholes formula. Due to market incompleteness, these formulae depend on the drift parameters of the processes. By making a further equilibrium assumption, we derive an approximate hedging formula, which does not require knowledge of these parameters. The hedging strategies are tested using Monte Carlo experiments, and are compared with results achieved using a utility maximization approach.

  14. 10 CFR 830.202 - Safety basis.

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Safety basis. 830.202 Section 830.202 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.202 Safety basis. (a) The contractor responsible for a hazard category 1, 2, or 3 DOE nuclear facility must establish and maintain the safety basis...

  15. Internal dosimetry technical basis manual

    1990-12-20

    The internal dosimetry program at the Savannah River Site (SRS) consists of radiation protection programs and activities used to detect and evaluate intakes of radioactive material by radiation workers. Examples of such programs are: air monitoring; surface contamination monitoring; personal contamination surveys; radiobioassay; and dose assessment. The objectives of the internal dosimetry program are to demonstrate that the workplace is under control and that workers are not being exposed to radioactive material, and to detect and assess inadvertent intakes in the workplace. The Savannah River Site Internal Dosimetry Technical Basis Manual (TBM) is intended to provide a technical and philosophical discussion of the radiobioassay and dose assessment aspects of the internal dosimetry program. Detailed information on air, surface, and personal contamination surveillance programs is not given in this manual except for how these programs interface with routine and special bioassay programs.

  16. FLAMMABLE GAS TECHNICAL BASIS DOCUMENT

    KRIPPS, L.J.

    2005-02-18

    This document describes the qualitative evaluation of frequency and consequences for double shell tank (DST) and single shell tank (SST) representative flammable gas accidents and associated hazardous conditions without controls. The evaluation indicated that safety-significant SSCs and/or TSRS were required to prevent or mitigate flammable gas accidents. Discussion on the resulting control decisions is included. This technical basis document was developed to support of the Tank Farms Documented Safety Analysis (DSA) and describes the risk binning process for the flammable gas representative accidents and associated represented hazardous conditions. The purpose of the risk binning process is to determine the need for safety-significant structures, systems, and components (SSC) and technical safety requirement (TSR)-level controls for a given representative accident or represented hazardous condition based on an evaluation of the event frequency and consequence.

  17. FLAMMABLE GAS TECHNICAL BASIS DOCUMENT

    KRIPPS, L.J.

    2005-03-03

    This document describes the qualitative evaluation of frequency and consequences for DST and SST representative flammable gas accidents and associated hazardous conditions without controls. The evaluation indicated that safety-significant structures, systems and components (SSCs) and/or technical safety requirements (TSRs) were required to prevent or mitigate flammable gas accidents. Discussion on the resulting control decisions is included. This technical basis document was developed to support WP-13033, Tank Farms Documented Safety Analysis (DSA), and describes the risk binning process for the flammable gas representative accidents and associated represented hazardous conditions. The purpose of the risk binning process is to determine the need for safety-significant structures, systems, and components (SSC) and technical safety requirement (TSR)-level controls for a given representative accident or represented hazardous condition based on an evaluation of the event frequency and consequence.

  18. Internal dosimetry technical basis manual

    1990-01-01

    The internal dosimetry program at the Savannah River Site (SRS) consists of radiation protection programs and activities used to detect and evaluate intakes of radioactive material by radiation workers. Examples of such programs are: air monitoring; surface contamination monitoring; personal contamination surveys; radiobioassay; and dose assessment. The objectives of the internal dosimetry program are to demonstrate that the workplace is under control and that workers are not being exposed to radioactive material, and to detect and assess inadvertent intakes in the workplace. The Savannah River Site Internal Dosimetry Technical Basis Manual (TBM) is intended to provide a technical and philosophical discussion of the radiobioassay and dose assessment aspects of the internal dosimetry program. Detailed information on air, surface, and personal contamination surveillance programs is not given in this manual except for how these programs interface with routine and special bioassay programs

  19. The neurological basis of occupation.

    Gutman, Sharon A; Schindler, Victoria P

    2007-01-01

    The purpose of the present paper was to survey the literature about the neurological basis of human activity and its relationship to occupation and health. Activities related to neurological function were organized into three categories: those that activate the brain's reward system; those that promote the relaxation response; and those that preserve cognitive function into old age. The results from the literature review correlating neurological evidence and activities showed that purposeful and meaningful activities could counter the effects of stress-related diseases and reduce the risk for dementia. Specifically, it was found that music, drawing, meditation, reading, arts and crafts, and home repairs, for example, can stimulate the neurogical system and enhance health and well-being, Prospective research studies are needed to examine the effects of purposeful activities on reducing stress and slowing the rate of cognitive decline.

  20. Infective basis in childhood leukaemia

    Kinlen, Leo

    1995-01-01

    Leukaemia in children has often been suspected of having an infective basis (as specifically identified in certain animal species) but, until recently, formal studies had gone no further than to show that it does not markedly cluster in time and space. Many infective illnesses, however, are uncommon responses to infections that are mainly spread by the majority of infected individuals who are not ill. These include, for example, glandular fever and certain types of meningitis. Such illnesses are not contagious and do not normally cluster. The possibilities that childhood leukamia might belong to this class of infective illnesses and be subject to increases in incidence as a result of epidemics of an underlying infection were suggested by the well-known excesses near Sellafield and Dounreay. (author)

  1. Molecular basis for mitochondrial signaling

    2017-01-01

    This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more re...

  2. Particle Reduction Strategies - PAREST. PM10-cause analysis based on hypothetical emissions scenarios. Sub-report; Strategien zur Verminderung der Feinstaubbelastung - PAREST. PM10-Ursachenanalyse auf der Basis hypothetischer Emissionsszenarien. Teilbericht

    Stern, Rainer [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie, Troposphaerische Umweltforschung

    2013-06-15

    In this report, a PM10 cause analysis is presented, which provides an estimation of the extent to which the emitted substances from ten different source sectors are responsible for the calculated PM10 concentrations in Germany (PM = particulate matter). [German] In diesem Bericht wird eine PM10-Ursachenanalyse vorgestellt, die eine Abschaetzung liefert, in welchem Umfang die in Deutschland von den verschiedenen Verursachergruppen emittierten Stoffe fuer die in Deutschland berechneten PM10-Konzentrationen verantwortlich sind.

  3. ITER task title - source term data, modelling, and analysis. ITER subtask no. S81TT05/5 (SEP 1-1). Global tritium source term analysis basis document. Subtask 1: operational tritium effluents and releases. Final report (1995 TASK)

    Kalyanam, K.M.

    1996-06-01

    This document represents the final report for the global tritium source term analysis task initiated in 1995. The report presents a room-by-room map/table at the subsystem level for the ITER tritium systems, identifying the major equipment, secondary containments, tritium release sources, duration/frequency of tritium releases and the release pathways. The chronic tritium releases during normal operation, as well as tritium releases due to routine maintenance of the Water Distillation Unit, Isotope Separation System and Primary and Secondary Heat Transport Systems, have been estimated for most of the subsystems, based on the IDR design, the Design Description Documents (April - Jun 1995 issues) and the design updates up to December 1995. The report also outlines the methodology and the key assumptions that are adopted in preparing the tritium release estimates. The design parameters for the ITER Basic Performance Phase (BPP) have been used in estimating the tritium releases shown in the room-by-room map/table. The tritium release calculations and the room-by-room map/table have been prepared in EXCEL, so that the estimates can be refined easily as the design evolves and more detailed information becomes available. (author). 23 refs., tabs

  4. Cold Vacuum Drying (CVD) Facility Design Basis Accident Analysis Documentation

    PIEPHO, M.G.

    1999-10-20

    This document provides the detailed accident analysis to support HNF-3553, Annex B, Spent Nuclear Fuel Project Final Safety Analysis Report, ''Cold Vacuum Drying Facility Final Safety Analysis Report (FSAR).'' All assumptions, parameters and models used to provide the analysis of the design basis accidents are documented to support the conclusions in the FSAR.

  5. Cold Vacuum Drying Facility Design Basis Accident Analysis Documentation

    PIEPHO, M.G.

    1999-01-01

    This document provides the detailed accident analysis to support HNF-3553, Annex B, Spent Nuclear Fuel Project Final Safety Analysis Report, ''Cold Vacuum Drying Facility Final Safety Analysis Report (FSAR).'' All assumptions, parameters and models used to provide the analysis of the design basis accidents are documented to support the conclusions in the FSAR

  6. 76 FR 72652 - Basis Reporting by Securities Brokers and Basis Determination for Debt Instruments and Options

    2011-11-25

    ..., acquisition premium, and market discount by assuming that the customer has not made any elections with respect... premium, and market discount. The Treasury Department and the IRS recognize that the section 171 election... to stock were published in the Federal Register on October 18, 2010, in TD 9504. The proposed...

  7. 75 FR 64071 - Basis Reporting by Securities Brokers and Basis Determination for Stock

    2010-10-18

    ... transition rule to allow time for programming and accounting system changes. The final regulations adopt this... Barter Exchange Transactions,'' provides a sufficient confirmation of the transaction. Alternatively, the...

  8. Conceptual basis of outcome measures.

    Keith, R A

    1995-01-01

    Because of its treatment configuration and the assumption of long-term benefit, rehabilitation has had a continuing interest in the measurement of outcomes. The utility of outcome indicators rests on their conceptual foundations, the technical development of measures and validation research. Some measures, particularly of functional status, have become increasingly sophisticated with the application of psychometric and statistical analysis techniques. Less effort has been devoted to an elaboration of their theoretical basis. A first step is an examination of the assumptions underlying outcome measures, the purpose of this article. Central to an understanding is clarification of definitions of key terms such as outcomes, independence, impairment, disability and handicap. All outcome measures must be seen as part of a social context of norms and expectations. However, most norms in rehabilitation are implied rather than explicit. The assumptions behind several common outcomes are examined with suggestions for ways to increase their utility. The ability of rehabilitation to compete in the current climate, stressing cost-effectiveness, will depend heavily on the robustness of outcome measures.

  9. Electron transport code theoretical basis

    Dubi, A.; Horowitz, Y.S.

    1978-04-01

    This report mainly describes the physical and mathematical considerations involved in the treatment of the multiple collision processes. A brief description is given of the traditional methods used in electron transport via Monte Carlo, and a somewhat more detailed description, of the approach to be used in the presently developed code

  10. Feasibility studies for final disposal of low and intermediate radioactive waste - summary with main conclusions and recommendations from three parallel studies. Report to the cross-departmental working group for preparing a decision basis for establishing a Danish radioactive waste disposal facility

    2011-05-01

    In 2003, the Danish Parliament in resolution No. B 48 on the dismantling of the nuclear facilities at Risoe gave consent to the government to begin preparation of a decision basis for a Danish final repository for low and intermediate level waste. As a result, a working group under the Ministry of Health and Prevention in 2008 prepared the report 'Decision basis for a Danish final repository for low and medium level radioactive waste'. In this report it was recommended to prepare three parallel preliminary studies: one about the repository concepts with the aim to obtain the necessary decision-making basis for selecting which concepts to analyze within the process of establishing a final repository, one on transportation of radioactive waste to the depot and one about regional mapping with the aim to characterize areas as suitable or unsuitable for locating a repository. The present report contains the main conclusions of each of the three parallel studies in relation to the further localization process. The preliminary studies suggest 22 areas, of which it is recommended to proceed with six in the selection process. The preliminary studies also show that all investigated storage concepts will be possible solutions from a security standpoint. However, there will be greater risks associated with depots near the surface, because they are more subjected to intentional or accidental intrusion. Overall, a medium deep repository will be the most appropriate solution, but it is also a more expensive solution than the near-surface repository. Both subsurface and the deep repositories may be reversible, but it is estimated to increase overall costs and may increase risk related to accidents. The preliminary studies establishes a set of conclusions and recommendations concerning future studies related to repository concepts and safety analyses, including in relation to the specific geology at the selected locations. The transportation studies show that radio

  11. Leerteoretiese basis van die andragogie

    C. J. A. Simpson

    1991-06-01

    Full Text Available Learning theory basis of andragogy. A cursory glance at andragogy creates the impression that humanistic learning theory plays an all encompassing role in the learner centered approach andragogy espouses. A closer look, however, reveals that Knowles (1973, after having made an intensive study of learning theory, created an extensive framework within which human resource development can take place. The fact that Knowles attracted critique from different areas, led to a need to ascertain the role different learning theories, if any, played in the emergence of andragogy. Having looked at the assumptions displayed by the andragogical approach, as well as a comparison of different learning theories and their connection with andragogy, it became clear that andragogy contains elements of various learning theories in an adapted way. These adaptations resulted in an approach to adult education in which learners are given the opportunity to be part of the learning process in such a way that they themselves contribute to the development which takes place. Opsomming Met 'n eerste oogopslag wil dit voorkom asof humanistiese leerteorie 'n oorheersende rol in die leerdergesentreerde benadering van andragogie speel. By nadere ondersoek blyk dit egter dat Knowles (1973, na 'n deeglike studie van verskillende leerteoretiese beginsels, 'n omvangryke raamwerk geskep het waarbinne, aan die hand van verskeie aangepaste leerteoretiese beginsels, menslike hulpbronontwikkeling kan plaasvind. As gevolg van die feit dat Knowles vanuit verskillende oorde kritiek op die lyf geloop het, is besluit om die rol wat verskillende leerteorieë in andragogie speel, te bestudeer. Dit blyk dat andragogie nie net elemente van verskillende leerteorieë bevat nie, maar dat toepaslike aspekte van die teoriee wat ondersoek is, benut en aangepas is om 'n geintegreerde benadering te bewerkstellig waarin veral volwassene-leerders by leergeleenthede en hulle selfontwikkeling betrek word.

  12. RETROCK Project. Treatment of geosphere retention phenomena in safety assessments. Scientific basis of retention processes and their implementation in safety assessment models (WP2). Work Package 2 report of the RETROCK Concerted Action

    Nykyri, M.

    2004-10-01

    This report considers the present-day understanding and approaches to take into account retention and transport processes in the performance assessment (PA) models used in the evaluation of the long-term safety of deep geological repositories for radioactive waste. It is a product of Work Package 2 in the RETROCK Concerted Action, a part of EURATOM's research and training programme. The processes emphasised in RETROCK are the influences of the flow field, matrix diffusion, and sorption on radionuclide transport characteristics. These processes, and radioactive decay, provide the key terms to the transport equations of the PA models. The following processes are handled more cursorily: colloid-facilitated transport, microbial activity, gas-mediated transport, precipitation/coprecipitation, and off diagonal Onsager processes. The environment in question is saturated sparsely fractured rock in the repository far field. The fracture network offers flow paths for the groundwater transporting radionuclides away from a repository. The radionuclides in various chemical forms interact physically and chemically with other matter in groundwater, fracture surfaces, fracture infills and the rock matrix adjacent to the fractures. These interactions typically result in significant retardation, and decay, of radionuclides compared to the velocity of the groundwater. The PA models usually take into account retention phenomena using simplified concepts that are justified by their conservatism. They are complemented by a large variety of more detailed and realistic process-specific models that can be used to support the choice of data for PA models, as well as specific arguments made in safety cases. While the fundamental understanding, the conceptualisations of the phenomena, the models and the computing resources develop, the extensive data requirements often become a most restrictive factor to the use of a model. The difficulties in obtaining data tend to hinder the utilisation of

  13. RETROCK Project. Treatment of geosphere retention phenomena in safety assessments. Scientific basis of retention processes and their implementation in safety assessment models (WP2). Work Package 2 report of the RETROCK Concerted Action

    Nykyri, M. [Safram Oy, Espoo (Finland)] [and others

    2004-10-01

    This report considers the present-day understanding and approaches to take into account retention and transport processes in the performance assessment (PA) models used in the evaluation of the long-term safety of deep geological repositories for radioactive waste. It is a product of Work Package 2 in the RETROCK Concerted Action, a part of EURATOM's research and training programme. The processes emphasised in RETROCK are the influences of the flow field, matrix diffusion, and sorption on radionuclide transport characteristics. These processes, and radioactive decay, provide the key terms to the transport equations of the PA models. The following processes are handled more cursorily: colloid-facilitated transport, microbial activity, gas-mediated transport, precipitation/coprecipitation, and off diagonal Onsager processes. The environment in question is saturated sparsely fractured rock in the repository far field. The fracture network offers flow paths for the groundwater transporting radionuclides away from a repository. The radionuclides in various chemical forms interact physically and chemically with other matter in groundwater, fracture surfaces, fracture infills and the rock matrix adjacent to the fractures. These interactions typically result in significant retardation, and decay, of radionuclides compared to the velocity of the groundwater. The PA models usually take into account retention phenomena using simplified concepts that are justified by their conservatism. They are complemented by a large variety of more detailed and realistic process-specific models that can be used to support the choice of data for PA models, as well as specific arguments made in safety cases. While the fundamental understanding, the conceptualisations of the phenomena, the models and the computing resources develop, the extensive data requirements often become a most restrictive factor to the use of a model. The difficulties in obtaining data tend to hinder the

  14. RETROCK Project. Treatment of geosphere retention phenomena in safety assessments. Scientific basis of retention processes and their implementation in safety assessment models (WP2). Work Package 2 report of the RETROCK Concerted Action

    Nykyri, M [Safram Oy, Espoo (Finland); and others

    2004-10-01

    This report considers the present-day understanding and approaches to take into account retention and transport processes in the performance assessment (PA) models used in the evaluation of the long-term safety of deep geological repositories for radioactive waste. It is a product of Work Package 2 in the RETROCK Concerted Action, a part of EURATOM's research and training programme. The processes emphasised in RETROCK are the influences of the flow field, matrix diffusion, and sorption on radionuclide transport characteristics. These processes, and radioactive decay, provide the key terms to the transport equations of the PA models. The following processes are handled more cursorily: colloid-facilitated transport, microbial activity, gas-mediated transport, precipitation/coprecipitation, and off diagonal Onsager processes. The environment in question is saturated sparsely fractured rock in the repository far field. The fracture network offers flow paths for the groundwater transporting radionuclides away from a repository. The radionuclides in various chemical forms interact physically and chemically with other matter in groundwater, fracture surfaces, fracture infills and the rock matrix adjacent to the fractures. These interactions typically result in significant retardation, and decay, of radionuclides compared to the velocity of the groundwater. The PA models usually take into account retention phenomena using simplified concepts that are justified by their conservatism. They are complemented by a large variety of more detailed and realistic process-specific models that can be used to support the choice of data for PA models, as well as specific arguments made in safety cases. While the fundamental understanding, the conceptualisations of the phenomena, the models and the computing resources develop, the extensive data requirements often become a most restrictive factor to the use of a model. The difficulties in obtaining data tend to hinder the utilisation of

  15. Oceanographic model and radiological basis for control of radionuclide releases

    Hagen, A.A.

    1984-01-01

    Since it first prepared the provisional Definition of high-level radioactive waste unsuitable for dumping at sea and Recommendations for those radioactive wastes dumped under special permit in 1974, the IAEA has kept the Definition and Recommendations under continuing review. The oceanographic basis for the definition is being re-evaluated, based on a 1983 Report from the IMO/FAO/UNESCO/WMO/WHO/IAEA/UN/UNEP Joint Group of Experts on the Scientific Aspects of Marine Pollution (GESAMP), and the radiological basis is being updated, based on a Report from an IAEA Advisory Group Meeting held in 1982. The differences in the current radiological and oceanographic bases and the updating of both the GESAMP Report on modelling and the review of the radiological basis are delineated. In addition, a discussion of the future course of the Agency's activities in this area is given. (author)

  16. Canister Storage Building (CSB) Design Basis Accident Analysis Documentation

    CROWE, R.D.

    1999-09-09

    This document provides the detailed accident analysis to support ''HNF-3553, Spent Nuclear Fuel Project Final Safety, Analysis Report, Annex A,'' ''Canister Storage Building Final Safety Analysis Report.'' All assumptions, parameters, and models used to provide the analysis of the design basis accidents are documented to support the conclusions in the Canister Storage Building Final Safety Analysis Report.

  17. Agricultural ecosystem modelling. The basis for assessing the impact of possible land-use and climate changes. Final report; Agrooekosystemmodellierung. Grundlage fuer die Abschaetzung von Auswirkungen moeglicher Landnutzungs- und Klimaaenderungen. Abschlussbericht

    Wenkel, K.O. [ed.; Mirschel, W. [ed.

    1995-12-31

    This report presents the results of the BMBF-sponsored project Fundamentals and models for assessing the effect of climate changes on soil, plant development and the crops of an economically significant range of farm products. Its aim was to study, by means of the results obtained for winter wheat, the dependence of plant growth on temperature, radiation and water as well as nutrient supply for other economically important crop types. Building on this, process-oriented, climate-sensitive agricultural ecosystem models for winter rye, winter barley, sugar-beet and winter intercrops were developed, verified and, in some sites, validated. First scenario calculations served to demonstrate the climate sensitivity of these models. (orig./KW) [Deutsch] Im vorliegenden Bericht werden die Ergebnisse des BMBF - Vorhabens `Grundlagen und Modelle zur Abschaetzung von Klimaaenderungen auf den Boden, die Pflanzenentwicklung sowie den verwertbaren Ernteertrag einer wirtschaftlich bedeutenden Marktfruchtfolge` vorgestellt. Ziel des Vorhabens war es, auf der Grundlage der Erkenntnisse zur Fruchtart Winterweizen die Abhaengigkeit des Pflanzenwachstums von Temperatur, Strahlung sowie Wasser- und Naehrstoffversorgung fuer weitere wirtschaftlich bedeutende landwirtschaftliche Fruchtarten zu untersuchen und auf diesen Ergebnissen aufbauend prozessorientierte klimasensitive Agrooekosystemmodelle fuer Winterroggen, Wintergerste, Zuckerrueben und Winterzwischenfruechte zu entwickeln, zu verifizieren und an einigen Standorten zu validieren. Mit Hilfe von ersten Szenariorechnungen war die Klimasensibilitaet dieser Modelle nachzuweisen. (orig./KW)

  18. Basis UST leak detection systems

    Silveria, V.

    1992-01-01

    This paper reports that gasoline and other petroleum products are leaking from underground storage tanks (USTs) at an alarming rate, seeping into soil and groundwater. Buried pipes are an even greater culprit, accounting for most suspected and detected leaks according to Environmental Protection Agency (EPA) estimates. In response to this problem, the EPA issued regulations setting standards for preventing, detecting, reporting, and cleaning up leaks, as well as fiscal responsibility. However, federal regulations are only a minimum; some states have cracked down even harder Plant managers and engineers have a big job ahead of them. The EPA estimates that there are more than 75,000 fuel USTs at US industrial facilities. When considering leak detection systems, the person responsible for making the decision has five primary choices: inventory reconciliation combined with regular precision tightness tests; automatic tank gauging; groundwater monitoring; interstitial monitoring of double containment systems; and vapor monitoring

  19. Genetic basis of endocrine pathology

    T.V. Sorokman

    2017-05-01

    Full Text Available The purpose of the review was analysis of literature data relating to the molecular genetic basis and diagnosis of endocrine pathology. We searched for published and unpublished researches using Pubmed as the search engine by the keywords: ‘genes’, ‘endocrine diseases’, ‘molecular diagnostics’, ‘prohormones’, ‘nuclear receptors and transcription factors’, taking into consideration studies conducted over the last 10 years, citation review of relevant primary and review articles, conference abstracts, personal files, and contact with expert informants. The criterion for the selection of articles for the study was based on their close relevance to the topic, thus out of 144 analyzed articles, the findings of the researchers covered in 32 articles were crucial. The described nosologies presented various heredi­tary forms of hypopituitarism, disturbances of steroid hormone biosynthesis, abnormal gender formation, monogenic forms of diabetes mellitus, endocrine tumors, etc. Pathology is identified that is associated with a mutation of genes encoding protein prohormones, receptors, steroid biosynthesis enzymes, intracellular signaling molecules, transport proteins, ion channels, and transcription factors. Among the endocrine diseases associated with defects in genes encoding protein prohormones, the defects of the GH1 gene are most common, the defects in the gene CYP21A2 (21-hydroxylase are among diseases associated with defects in genes encoding enzymes. More often mutations of genes encoding proteins belong to the class of G-protein coupled receptors. Most of the mutations associated with MEN-2A are concentrated in the rich cysteine region of the Ret receptor. More than 70 monogenic syndromes are known, in which there is a marked tolerance to glucose and some form of diabetes mellitus is diagnosed, diabetes mellitus caused by mutation of the mitochondrial gene (mutation tRNALeu, UUR is also detected. Of all the monogenic forms of

  20. Neurobiological Basis of Alcohol Addiction

    Milagros Lisset León Regal

    2014-02-01

    Full Text Available Alcoholism is a serious social problem due to its impact on individual and collective health. In order to provide an update on the latest findings that explain the development and symptoms of alcohol addiction, the short and long term changes that this disorder causes in the central nervous system are shown in this paper. A total of 52 information sources were consulted, including 43 journal articles, 4 books and statistical reports. The main network managers were used. The interaction of ethanol with various structures of the neuronal membrane affects the cytoarchitecture and brain function associated with the reward system, motor processing, learning and memory, resulting in the development of alcohol dependence. In addition, ethanol-induced changes in excitation/inhibition explain the phenomena of alcohol tolerance and withdrawal.

  1. Closed fringe demodulation using phase decomposition by Fourier basis functions.

    Kulkarni, Rishikesh; Rastogi, Pramod

    2016-06-01

    We report a new technique for the demodulation of a closed fringe pattern by representing the phase as a weighted linear combination of a certain number of linearly independent Fourier basis functions in a given row/column at a time. A state space model is developed with the weights of the basis functions as the elements of the state vector. The iterative extended Kalman filter is effectively utilized for the robust estimation of the weights. A coarse estimate of the fringe density based on the fringe frequency map is used to determine the initial row/column to start with and subsequently the optimal number of basis functions. The performance of the proposed method is evaluated with several noisy fringe patterns. Experimental results are also reported to support the practical applicability of the proposed method.

  2. Neuroimmune Basis of Methamphetamine Toxicity

    Loftis, Jennifer M.; Janowsky, Aaron

    2015-01-01

    Although it is not known which antigen-specific immune responses (or if antigen-specific immune responses) are relevant or required for methamphetamine's neurotoxic effects, it is apparent that methamphetamine exposure is associated with significant effects on adaptive and innate immunity. Alterations in lymphocyte activity and number, changes in cytokine signaling, impairments in phagocytic functions, and glial activation and gliosis have all been reported. These drug-induced changes in immune response, particularly within the CNS, are now thought to play a critical role in the addiction process for methamphetamine dependence as well as for other substance use disorders. In Section 2, methamphetamine's effects on glial cell (e.g., microglia and astrocytes) activity and inflammatory signaling cascades are summarized, including how alterations in immune cell function can induce the neurotoxic and addictive effects of methamphetamine. Section 2 also describes neurotransmitter involvement in the modulation of methamphetamine's inflammatory effects. Section 3 discusses the very recent use of pharmacological and genetic animal models which have helped elucidate the behavioral effects of methamphetamine's neurotoxic effects and the role of the immune system. Section 4 is focused on the effects of methamphetamine on blood–brain barrier integrity and associated immune consequences. Clinical considerations such as the combined effects of methamphetamine and HIV and/or HCV on brain structure and function are included in Section 4. Finally, in Section 5, immune-based treatment strategies are reviewed, with a focus on vaccine development, neuroimmune therapies, and other anti-inflammatory approaches. PMID:25175865

  3. Accelerated Best Basis Inventory Baselining Task

    SASAKI, L.M.

    2001-01-01

    The baselining effort was recently proposed to bring the Best-Basis Inventory (BBI) and Question No.8 of the Tank Interpretive Report (TIR) for all 177 tanks to the current standards and protocols and to prepare a TIR Question No.8 if one is not already available. This plan outlines the objectives and methodology of the accelerated BBI baselining task. BBI baselining meetings held during December 2000 resulted in a revised BBI methodology and an initial set of BBI creation rules to be used in the baselining effort. The objectives of the BBI baselining effort are to: (1) Provide inventories that are consistent with the revised BBI methodology and new BBI creation rules. (2) Split the total tank waste in each tank into six waste phases, as appropriate (Supernatant, saltcake solids, saltcake liquid, sludge solids, sludge liquid, and retained gas). In some tanks, the solids and liquid portions of the sludge and/or saltcake may be combined into a single sludge or saltcake phase. (3) Identify sampling events that are to be used for calculating the BBIs. (4) Update waste volumes for subsequent reconciliation with the Hanlon (2001) waste tank summary. (5) Implement new waste type templates. (6) Include any sample data that might have been unintentionally omitted in the previous BBI and remove any sample data that should not have been included. Sample data to be used in the BBI must be available on TWINS. (7) Ensure that an inventory value for each standard BBI analyte is provided for each waste component. Sample based inventories for supplemental BBI analytes will be included when available. (8) Provide new means and confidence interval reports if one is not already available and include uncertainties in reporting inventory values

  4. The Social Basis of Math Teaching and Learning. Final Report.

    Orvik, James M.; Van Veldhuizen, Philip A.

    This study was designed to identify a set of research questions and testable hypothesis to aid in planning long-range research. Five mathematics teachers were selected. These instructors enrolled in a special project-related seminar, video-taped sessions of their own mathematics classes, and kept field journals. The group met once a week to…

  5. System requirements and design description for the document basis database interface (DocBasis)

    Lehman, W.J.

    1997-01-01

    This document describes system requirements and the design description for the Document Basis Database Interface (DocBasis). The DocBasis application is used to manage procedures used within the tank farms. The application maintains information in a small database to track the document basis for a procedure, as well as the current version/modification level and the basis for the procedure. The basis for each procedure is substantiated by Administrative, Technical, Procedural, and Regulatory requirements. The DocBasis user interface was developed by Science Applications International Corporation (SAIC)

  6. Estimating the CCSD basis-set limit energy from small basis sets: basis-set extrapolations vs additivity schemes

    Spackman, Peter R.; Karton, Amir, E-mail: amir.karton@uwa.edu.au [School of Chemistry and Biochemistry, The University of Western Australia, Perth, WA 6009 (Australia)

    2015-05-15

    Coupled cluster calculations with all single and double excitations (CCSD) converge exceedingly slowly with the size of the one-particle basis set. We assess the performance of a number of approaches for obtaining CCSD correlation energies close to the complete basis-set limit in conjunction with relatively small DZ and TZ basis sets. These include global and system-dependent extrapolations based on the A + B/L{sup α} two-point extrapolation formula, and the well-known additivity approach that uses an MP2-based basis-set-correction term. We show that the basis set convergence rate can change dramatically between different systems(e.g.it is slower for molecules with polar bonds and/or second-row elements). The system-dependent basis-set extrapolation scheme, in which unique basis-set extrapolation exponents for each system are obtained from lower-cost MP2 calculations, significantly accelerates the basis-set convergence relative to the global extrapolations. Nevertheless, we find that the simple MP2-based basis-set additivity scheme outperforms the extrapolation approaches. For example, the following root-mean-squared deviations are obtained for the 140 basis-set limit CCSD atomization energies in the W4-11 database: 9.1 (global extrapolation), 3.7 (system-dependent extrapolation), and 2.4 (additivity scheme) kJ mol{sup –1}. The CCSD energy in these approximations is obtained from basis sets of up to TZ quality and the latter two approaches require additional MP2 calculations with basis sets of up to QZ quality. We also assess the performance of the basis-set extrapolations and additivity schemes for a set of 20 basis-set limit CCSD atomization energies of larger molecules including amino acids, DNA/RNA bases, aromatic compounds, and platonic hydrocarbon cages. We obtain the following RMSDs for the above methods: 10.2 (global extrapolation), 5.7 (system-dependent extrapolation), and 2.9 (additivity scheme) kJ mol{sup –1}.

  7. Estimating the CCSD basis-set limit energy from small basis sets: basis-set extrapolations vs additivity schemes

    Spackman, Peter R.; Karton, Amir

    2015-01-01

    Coupled cluster calculations with all single and double excitations (CCSD) converge exceedingly slowly with the size of the one-particle basis set. We assess the performance of a number of approaches for obtaining CCSD correlation energies close to the complete basis-set limit in conjunction with relatively small DZ and TZ basis sets. These include global and system-dependent extrapolations based on the A + B/L α two-point extrapolation formula, and the well-known additivity approach that uses an MP2-based basis-set-correction term. We show that the basis set convergence rate can change dramatically between different systems(e.g.it is slower for molecules with polar bonds and/or second-row elements). The system-dependent basis-set extrapolation scheme, in which unique basis-set extrapolation exponents for each system are obtained from lower-cost MP2 calculations, significantly accelerates the basis-set convergence relative to the global extrapolations. Nevertheless, we find that the simple MP2-based basis-set additivity scheme outperforms the extrapolation approaches. For example, the following root-mean-squared deviations are obtained for the 140 basis-set limit CCSD atomization energies in the W4-11 database: 9.1 (global extrapolation), 3.7 (system-dependent extrapolation), and 2.4 (additivity scheme) kJ mol –1 . The CCSD energy in these approximations is obtained from basis sets of up to TZ quality and the latter two approaches require additional MP2 calculations with basis sets of up to QZ quality. We also assess the performance of the basis-set extrapolations and additivity schemes for a set of 20 basis-set limit CCSD atomization energies of larger molecules including amino acids, DNA/RNA bases, aromatic compounds, and platonic hydrocarbon cages. We obtain the following RMSDs for the above methods: 10.2 (global extrapolation), 5.7 (system-dependent extrapolation), and 2.9 (additivity scheme) kJ mol –1

  8. Scientific basis for nuclear waste management

    Topp, S.V.

    1982-01-01

    This volume contains the proceedings of the fourth International Symposium on the Scientific Basis for Nuclear Waste Management, held in Boston, Massachusetts, on November 16-19, 1981, as part of the Annual Meeting of the Materials Research Society. The purpose of this Symposium was to provide an interdisciplinary forum for the discussion of scientific research dealing with all levels and types of radioactive wastes and their management. These symposia have been held annually since 1978. The proceedings of the first three meetings were published as Volumes 1, 2, and 3 in a series. With this, the fourth meeting, the volume numbering system is changed to coincide with the system used to number Materials Research Society Annual Meeting Proceedings. The reports presented here give the results of research and development activities from a large number of universities, government laboratories and private industry in nine countries. The 92 papers published in these proceedings have been divided into 92 chapters. These encompass various aspects of high-level and non-high-level radioactive waste management ranging from repository characterization and waste form production to product and performance assessment. All of the papers have been abstracted and indexed for the data base

  9. The basis for the strengthening of safeguards

    Goldschmidt, P.

    1999-01-01

    For the past 30 years, the International Atomic Energy Agency's safeguards system has contributed to the international non-proliferation regime, by providing, inter alia, assurances regarding the peaceful uses of declared nuclear material. However, the discovery of a clandestine nuclear weapons programme in Iraq in 1991 drew world-wide attention to the need to strengthen the system to address the absence of undeclared nuclear material and activities. Efforts to strengthen the IAEA's safeguards system began in 1991 and culminated in 1997 when the IAEA's Board of Governors approved a Model Protocol Additional to IAEA Safeguards Agreements which greatly expands the legal basis and scope of IAEA safeguards. Within this strengthened system it is expected that the IAEA be able to provide assurance not only of the absence of diversion of declared nuclear material but also on the absence of undeclared nuclear material and activities. This is to be done within a safeguards system that uses an optimal combination of all safeguards measures available, thereby achieving maximum effectiveness and efficiency within the available resources. This paper will summarize the evolution of the safeguards system, describe strengthened safeguards, report on the status of implementing the strengthening measures, and outline plans for integrating all available safeguards measures. (author)

  10. Structural basis of kynurenine 3-monooxygenase inhibition.

    Amaral, Marta; Levy, Colin; Heyes, Derren J; Lafite, Pierre; Outeiro, Tiago F; Giorgini, Flaviano; Leys, David; Scrutton, Nigel S

    2013-04-18

    Inhibition of kynurenine 3-monooxygenase (KMO), an enzyme in the eukaryotic tryptophan catabolic pathway (that is, kynurenine pathway), leads to amelioration of Huntington's-disease-relevant phenotypes in yeast, fruitfly and mouse models, as well as in a mouse model of Alzheimer's disease. KMO is a flavin adenine dinucleotide (FAD)-dependent monooxygenase and is located in the outer mitochondrial membrane where it converts l-kynurenine to 3-hydroxykynurenine. Perturbations in the levels of kynurenine pathway metabolites have been linked to the pathogenesis of a spectrum of brain disorders, as well as cancer and several peripheral inflammatory conditions. Despite the importance of KMO as a target for neurodegenerative disease, the molecular basis of KMO inhibition by available lead compounds has remained unknown. Here we report the first crystal structure of Saccharomyces cerevisiae KMO, in the free form and in complex with the tight-binding inhibitor UPF 648. UPF 648 binds close to the FAD cofactor and perturbs the local active-site structure, preventing productive binding of the substrate l-kynurenine. Functional assays and targeted mutagenesis reveal that the active-site architecture and UPF 648 binding are essentially identical in human KMO, validating the yeast KMO-UPF 648 structure as a template for structure-based drug design. This will inform the search for new KMO inhibitors that are able to cross the blood-brain barrier in targeted therapies against neurodegenerative diseases such as Huntington's, Alzheimer's and Parkinson's diseases.

  11. Conceptual basis of the master directed diagram

    Kelly, M.; Billington, D.

    1998-01-01

    This document forms part of a suite of documents describing the Nirex model development programme. The programme is designed to provide a clear audit trail from the identification of significant features, events and processes (FEPs) to the models and modelling processes employed within a detailed safety assessment. A five stage approach has been adopted, which provides a systematic framework for addressing uncertainty and for the documentation of all modelling decisions and assumptions. The five stages are as follows: Stage 1: EP analysis - compilation and structuring of a FEP database; Stage 2: Scenario and conceptual model development; Stage 3: mathematical model development; Stage 4: Software development; Stage 5: confidence building. This report describes the work involved in Stage 1 of the Nirex model development programme, FEP analysis. The aim of FEP analysis is to produce a set of FEPs and FEP interactions that form the basis for the scenario and conceptual model development in Stage 2. There are two requirements for the set of FEPs and FEP interactions; first, all aspects material to the performance of the disposal system should be covered, i.e. the set should be comprehensive, and secondly a clear audit trail of decisions, consensus and analysis should be maintained

  12. Physicochemical and physiological basis of dichromatic colour

    Kreft, Samo; Kreft, Marko

    2007-11-01

    Out of three perceptual characteristics of the colour of any substance, the hue depends mostly on the spectral properties of a substance, while the brightness and saturation depend also on the concentration of a substance and its thickness. Here, we report that evident change of the hue of the colour (i.e., from green to red) is due to a change in concentration or the thickness of a layer in some exceptional substances such as pumpkin seed oil or an aqueous solution of bromophenol blue. In some regions of Central Europe, salad dressing is made preferably with the pumpkin seed oil, which has a strong characteristic nut-like taste and remarkable properties of the colour: it appears red in a bottle, but green when served as a salad dressing. The colour of the pumpkin seed oil was previously described as brownish yellow, dark green, dark green to red ochre or dark reddish brown to light yellow green. We elucidated the physicochemical and physiological basis of such dichromatism by Beer-Lambert law and by the characteristics of human colour perception. Our concept was corroborated by the outcome of calculations of colour from spectral properties using colour matching functions. We found that dichromatism is observed if the absorption spectrum of any substance has at least two local minima: one wide but shallow and one narrow but deep local minimum.

  13. Guidelines for determining design basis ground motions

    1993-11-01

    This report develops and applies a method for estimating strong earthquake ground motion. The emphasis of this study is on ground motion estimation in Eastern North America (east of the Rocky Mountains), with particular emphasis on the Eastern United States and southeastern Canada. Specifically considered are ground motions resulting from earthquakes with magnitudes from 5 to 8, fault distances from 0 to 500 km, and frequencies from 1 to 35 Hz. The two main objectives were: (1) to develop generic relations for estimating ground motion appropriate for site screening; and (2) to develop a guideline for conducting a thorough site investigation needed to define the seismic design basis. For the first objective, an engineering model was developed to predict the expected ground motion on rock sites, with an additional set of amplification factors to account for the response of the soil column over rock at soil sites. The results incorporate best estimates of ground motion as well as the randomness and uncertainty associated with those estimates. For the second objective, guidelines were developed for gathering geotechnical information at a site and using this information in calculating site response. As a part of this development, an extensive set of geotechnical and seismic investigations was conducted at three reference sites. Together, the engineering model and guidelines provide the means to select and assess the seismic suitability of a site

  14. Solar Power Tower Design Basis Document, Revision 0

    ZAVOICO,ALEXIS B.

    2001-07-01

    This report contains the design basis for a generic molten-salt solar power tower. A solar power tower uses a field of tracking mirrors (heliostats) that redirect sunlight on to a centrally located receiver mounted on top a tower, which absorbs the concentrated sunlight. Molten nitrate salt, pumped from a tank at ground level, absorbs the sunlight, heating it up to 565 C. The heated salt flows back to ground level into another tank where it is stored, then pumped through a steam generator to produce steam and make electricity. This report establishes a set of criteria upon which the next generation of solar power towers will be designed. The report contains detailed criteria for each of the major systems: Collector System, Receiver System, Thermal Storage System, Steam Generator System, Master Control System, and Electric Heat Tracing System. The Electric Power Generation System and Balance of Plant discussions are limited to interface requirements. This design basis builds on the extensive experience gained from the Solar Two project and includes potential design innovations that will improve reliability and lower technical risk. This design basis document is a living document and contains several areas that require trade-studies and design analysis to fully complete the design basis. Project- and site-specific conditions and requirements will also resolve open To Be Determined issues.

  15. Riesz basis for strongly continuous groups.

    Zwart, Heiko J.

    Given a Hilbert space and the generator of a strongly continuous group on this Hilbert space. If the eigenvalues of the generator have a uniform gap, and if the span of the corresponding eigenvectors is dense, then these eigenvectors form a Riesz basis (or unconditional basis) of the Hilbert space.

  16. Determination of Design Basis Earthquake ground motion

    Kato, Muneaki

    1997-01-01

    This paper describes principle of determining of Design Basis Earthquake following the Examination Guide, some examples on actual sites including earthquake sources to be considered, earthquake response spectrum and simulated seismic waves. In sppendix of this paper, furthermore, seismic safety review for N.P.P designed before publication of the Examination Guide was summarized with Check Basis Earthquake. (J.P.N.)

  17. Determination of Design Basis Earthquake ground motion

    Kato, Muneaki [Japan Atomic Power Co., Tokyo (Japan)

    1997-03-01

    This paper describes principle of determining of Design Basis Earthquake following the Examination Guide, some examples on actual sites including earthquake sources to be considered, earthquake response spectrum and simulated seismic waves. In sppendix of this paper, furthermore, seismic safety review for N.P.P designed before publication of the Examination Guide was summarized with Check Basis Earthquake. (J.P.N.)

  18. Safeguards agreements - their legal and conceptual basis

    Sanders, B.; Rainer, R.

    1977-01-01

    The application of Agency safeguards requires treaty arrangements (''Safeguards Agreements'') between the State or States concerned and the Agency. The authority for the Agency to conclude such agreements and to implement them is provided for in the Agency's Statute (Articles II, III A.5 and XII). On the basis of the statutory provisions safeguards principles and procedures have been elaborated. These have been laid down in: (a) The Agency's Safeguards System 1965, extended in 1966 and 1968 (INFCIRC/66/Rev.2); and (b) The basis for negotiating safeguards agreements with NNWS pursuant to NPT (INFCIRC/153). The verification of the undertaking by the State concerned not to use items subject to safeguards for purposes contrary to the terms of the agreement is verified through the application of various safeguards measures (design review, records, reports and inspection). Containment and surveillance measures are expected to play an increasingly important role. NPT Safeguards Agreements foresee as one of their specific features the establishment of national systems of accounting and control of nuclear material. The majority of the agreements concluded under document INFCIRC/66/Rev.2 - i.e. the non-NPT safeguards agreements - implement obligations undertaken under co-operation agreements between States for peaceful uses of nuclear energy. These agreements naturally reflect approaches adopted by the parties, in particular as to the circumstances under which safeguards should be applied. Thus, the concepts used in the non-NPT safeguards agreements and the safeguards system of document INFCIRC/66/Rev.2 which is incorporated in these agreements by reference are in continuous evolution. Document INFCIRC/66/Rev.2 continues to be supplemented in practical application and through explicit decision by the Board. The non-NPT safeguards agreements contain, besides technical safeguards provisions from document INFCIRC/66/Rev.2, and further provision for notification, inventories

  19. Understanding and capturing NSSS design basis

    Palo, W.J.; Miller, B.

    1993-01-01

    Changes to, and technical evaluations of nuclear generating station designs are often warranted. Comprehensive documentation and understanding of the NSSS Design Basis are essential to support these activities. Effective configuration management tools are also needed to maintain the plant within design basis limits. Efficient design basis reconstitution can be realized via: In-depth understanding of the design process; Utilization of effective data collection methodology; State of the art data basing tools. A database can be created to generate a Design Basis Manual (DBM). This database can communicate electronically with other plant databases. A living document vice a static snapshot of the plant design is the goal. A design basis database can serve as the cornerstone for a global electronic information control system

  20. Advanced Test Reactor Safety Basis Upgrade Lessons Learned Relative to Design Basis Verification and Safety Basis Management

    G. L. Sharp; R. T. McCracken

    2004-01-01

    The Advanced Test Reactor (ATR) is a pressurized light-water reactor with a design thermal power of 250 MW. The principal function of the ATR is to provide a high neutron flux for testing reactor fuels and other materials. The reactor also provides other irradiation services such as radioisotope production. The ATR and its support facilities are located at the Test Reactor Area of the Idaho National Engineering and Environmental Laboratory (INEEL). An audit conducted by the Department of Energy's Office of Independent Oversight and Performance Assurance (DOE OA) raised concerns that design conditions at the ATR were not adequately analyzed in the safety analysis and that legacy design basis management practices had the potential to further impact safe operation of the facility.1 The concerns identified by the audit team, and issues raised during additional reviews performed by ATR safety analysts, were evaluated through the unreviewed safety question process resulting in shutdown of the ATR for more than three months while these concerns were resolved. Past management of the ATR safety basis, relative to facility design basis management and change control, led to concerns that discrepancies in the safety basis may have developed. Although not required by DOE orders or regulations, not performing design basis verification in conjunction with development of the 10 CFR 830 Subpart B upgraded safety basis allowed these potential weaknesses to be carried forward. Configuration management and a clear definition of the existing facility design basis have a direct relation to developing and maintaining a high quality safety basis which properly identifies and mitigates all hazards and postulated accident conditions. These relations and the impact of past safety basis management practices have been reviewed in order to identify lessons learned from the safety basis upgrade process and appropriate actions to resolve possible concerns with respect to the current ATR safety

  1. TECHNICAL BASIS FOR VENTILATION REQUIREMENTS IN TANK FARMS OPERATING SPECIFICATIONS DOCUMENTS

    BERGLIN, E J

    2003-06-23

    This report provides the technical basis for high efficiency particulate air filter (HEPA) for Hanford tank farm ventilation systems (sometimes known as heating, ventilation and air conditioning [HVAC]) to support limits defined in Process Engineering Operating Specification Documents (OSDs). This technical basis included a review of older technical basis and provides clarifications, as necessary, to technical basis limit revisions or justification. This document provides an updated technical basis for tank farm ventilation systems related to Operation Specification Documents (OSDs) for double-shell tanks (DSTs), single-shell tanks (SSTs), double-contained receiver tanks (DCRTs), catch tanks, and various other miscellaneous facilities.

  2. 26 CFR 1.1014-4 - Uniformity of basis; adjustment to basis.

    2010-04-01

    ...) INCOME TAX (CONTINUED) INCOME TAXES Basis Rules of General Application § 1.1014-4 Uniformity of basis... to property acquired by bequest, devise, or inheritance relate back to the death of the decedent... prescribing a general uniform basis rule for property acquired from a decedent is, on the one hand, to tax the...

  3. 21 CFR 120.9 - Legal basis.

    2010-04-01

    ... CONSUMPTION HAZARD ANALYSIS AND CRITICAL CONTROL POINT (HACCP) SYSTEMS General Provisions § 120.9 Legal basis. Failure of a processor to have and to implement a Hazard Analysis and Critical Control Point (HACCP... implementation of its HACCP system. ...

  4. 29 CFR 541.605 - Fee basis.

    2010-07-01

    ... DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE SALES EMPLOYEES Salary Requirements § 541.605 Fee basis. (a) Administrative and professional employees may be paid on a...

  5. Myelography conducted on an outpatient basis

    Kausch, W

    1981-03-01

    The introduction of the non-ionogenic product metrizamide made lumbosacral myelography a low-risk, invasive diagnostic procedure. Examination carried out on an outpatient basis does not involve greater risks or side effects than examination on a inpatient basis. However, it is essential that - apart from informing the patient properly - the patient shows discipline and remains available for the examining physician during a period of 36 hours.

  6. Advances in the physics basis for the European DEMO design

    Wenninger, R.; Arbeiter, F.; Aubert, J.; Aho-Mantila, L.; Albanese, R.; Ambrosino, R.; Angioni, C.; Artaud, J.-F.; Bernert, M.; Fable, E.; Fasoli, A.; Federici, G.; Garcia, J.; Giruzzi, G.; Jenko, F.; Maget, P.; Mattei, M.; Maviglia, F.; Poli, E.; Ramogida, G.; Reux, C.; Schneider, M.; Sieglin, B.; Villone, F.; Wischmeier, M.; Zohm, H.

    2015-06-01

    In the European fusion roadmap, ITER is followed by a demonstration fusion power reactor (DEMO), for which a conceptual design is under development. This paper reports the first results of a coherent effort to develop the relevant physics knowledge for that (DEMO Physics Basis), carried out by European experts. The program currently includes investigations in the areas of scenario modeling, transport, MHD, heating & current drive, fast particles, plasma wall interaction and disruptions.

  7. Development of new auxiliary basis functions of the Karlsruhe segmented contracted basis sets including diffuse basis functions (def2-SVPD, def2-TZVPPD, and def2-QVPPD) for RI-MP2 and RI-CC calculations.

    Hellweg, Arnim; Rappoport, Dmitrij

    2015-01-14

    We report optimized auxiliary basis sets for use with the Karlsruhe segmented contracted basis sets including moderately diffuse basis functions (Rappoport and Furche, J. Chem. Phys., 2010, 133, 134105) in resolution-of-the-identity (RI) post-self-consistent field (post-SCF) computations for the elements H-Rn (except lanthanides). The errors of the RI approximation using optimized auxiliary basis sets are analyzed on a comprehensive test set of molecules containing the most common oxidation states of each element and do not exceed those of the corresponding unaugmented basis sets. During these studies an unsatisfying performance of the def2-SVP and def2-QZVPP auxiliary basis sets for Barium was found and improved sets are provided. We establish the versatility of the def2-SVPD, def2-TZVPPD, and def2-QZVPPD basis sets for RI-MP2 and RI-CC (coupled-cluster) energy and property calculations. The influence of diffuse basis functions on correlation energy, basis set superposition error, atomic electron affinity, dipole moments, and computational timings is evaluated at different levels of theory using benchmark sets and showcase examples.

  8. The neural basis of bounded rational behavior

    Coricelli, Giorgio

    2012-03-01

    Full Text Available Bounded rational behaviour is commonly observed in experimental games and in real life situations. Neuroeconomics can help to understand the mental processing underlying bounded rationality and out-of-equilibrium behaviour. Here we report results from recent studies on the neural basis of limited steps of reasoning in a competitive setting —the beauty contest game. We use functional magnetic resonance imaging (fMRI to study the neural correlates of human mental processes in strategic games. We apply a cognitive hierarchy model to classify subject’s choices in the experimental game according to the degree of strategic reasoning so that we can identify the neural substrates of different levels of strategizing. We found a correlation between levels of strategic reasoning and activity in a neural network related to mentalizing, i.e. the ability to think about other’s thoughts and mental states. Moreover, brain data showed how complex cognitive processes subserve the higher level of reasoning about others. We describe how a cognitive hierarchy model fits both behavioural and brain data.

    La racionalidad limitada es un fenómeno observado de manera frecuente tanto en juegos experimentales como en situaciones cotidianas. La Neuroeconomía puede mejorar la comprensión de los procesos mentales que caracterizan la racionalidad limitada; en paralelo nos puede ayudar a comprender comportamientos que violan el equilibrio. Nuestro trabajo presenta resultados recientes sobre la bases neuronales del razonamiento estratégico (y sus límite en juegos competitivos —como el juego del “beauty contest”. Estudiamos las bases neuronales del comportamiento estratégico en juegos con interacción entre sujetos usando resonancia magnética funcional (fMRI. Las decisiones de los participantes se clasifican acorde al grado de razonamiento estratégico: el llamado modelo de Jerarquías Cognitivas. Los resultados muestran una correlación entre niveles de

  9. Measurement of basis weight by radiation gauge

    Buchnea, A.

    1981-01-01

    For accurate measurement of the basis weight (mass per unit area) of a material such as paper between a radioactive source and an ionization chamber the apparatus is calibrated by using a plurality of standards of known basis weight to provide a relationship between basis weight and the output current of the chamber which includes at least terms of the second order and preferably terms of higher orders. The major portion of the radiation path is enclosed in airtight chambers which are sufficiently rigid that the density therein is independent of ambient temperature and pressure variations. The accuracy is increased by measuring ambient temperature and pressure fluctuations, and linearly compensating for resultant density variations in the air gap through which the paper web passes. A wheel holding the standards is induced by a motor and a perforated encoding disc. (author)

  10. Coulomb interaction in the supermultiplet basis

    Ruzha, Ya.Kh.; Guseva, T.V.; Tamberg, Yu.Ya.; Vanagas, V.V.

    1989-01-01

    An approximate expression for the matrix elements of the Coulomb interaction operator in the supermultiplet basis has been derived with the account for the orbitally-nonsymmetric terms. From the general expression a simplified formula for the Coulomb interaction energy has been proposed. On the basis of the expression obtained the contribution of the Coulomb interaction to the framework of a strongly restricted dynamic model in the light (4≤A≤40) and heavy (158≤A≤196) nuclei region has been studied. 19 refs.; 4 tabs

  11. The Matlab Radial Basis Function Toolbox

    Scott A. Sarra

    2017-03-01

    Full Text Available Radial Basis Function (RBF methods are important tools for scattered data interpolation and for the solution of Partial Differential Equations in complexly shaped domains. The most straight forward approach used to evaluate the methods involves solving a linear system which is typically poorly conditioned. The Matlab Radial Basis Function toolbox features a regularization method for the ill-conditioned system, extended precision floating point arithmetic, and symmetry exploitation for the purpose of reducing flop counts of the associated numerical linear algebra algorithms.

  12. Heavy quarkonium in a holographic basis

    Yang Li

    2016-07-01

    Full Text Available We study the heavy quarkonium within the basis light-front quantization approach. We implement the one-gluon exchange interaction and a confining potential inspired by light-front holography. We adopt the holographic light-front wavefunction (LFWF as our basis function and solve the non-perturbative dynamics by diagonalizing the Hamiltonian matrix. We obtain the mass spectrum for charmonium and bottomonium. With the obtained LFWFs, we also compute the decay constants and the charge form factors for selected eigenstates. The results are compared with the experimental measurements and with other established methods.

  13. Determination of a Basis for Design of a Yam (Dioscorea Spp ...

    Manual separation is both tedious and expensive, so the work reported here was done to determine a suitable basis for the design of a mechanical minisett sorter. Results from this study showed that the minisetts cut from the regions of the parent tuber can be separated on the basis of characteristic dimensions of arc length ...

  14. TWRS authorization basis configuration control summary

    Mendoza, D.P.

    1997-01-01

    This document was developed to define the Authorization Basis management functional requirements for configuration control, to evaluate the management control systems currently in place, and identify any additional controls that may be required until the TWRS [Tank Waste Remediation System] Configuration Management system is fully in place

  15. Fundamentals of futures, options, basis and derivatives

    Jones, D. [TD Securities Inc., Toronto, ON (Canada)

    1997-08-01

    Characteristic features of futures and options contracts, basis differentials and derivatives were defined and explained. A futures contract refers to an exchange-traded supply contract between a buyer and a seller where the buyer is obligated to take delivery and the seller is obligated to provide delivery of a fixed amount of a commodity at a predetermined price at a specified location. In contrast, an option contract gives the purchaser the right, but not the obligation, to buy or sell the underlying commodity at a certain price on or before an agreed date. Basis differential refers to the discount between two distinct delivery points to reflect the relative value of a commodity, such as natural gas, at those points. Advantages and disadvantages of futures and options contacts, the factors affecting options pricing, and basis differentials, and the methods of calculating basis differentials were described. The nature and intricacies of derivatives, their benefits, in particular their use as a tool for the effective management of the volatilities associated with the oil and gas industry were explained. Their shortcomings such as the high liquidity risk, were also described. Examples of derivative transactions were provided to illustrate the interrelationships of futures/options/derivatives, and their role in financial risk management.

  16. Canonical three-body angular basis

    Matveenko, A.V.

    2001-01-01

    Three-body problems are basic for the quantum mechanics of molecular, atomic, or nuclear systems. We demonstrate that their variational solution for rotational states can be greatly simplified. A special choice of coordinates (hyperspherical) and of the kinematics (body-fixed coordinate frame) allows one to choose basis functions in a form that makes the angular coupling trivial. (author)

  17. M4GB : Efficient Groebner Basis algorithm

    R.H. Makarim (Rusydi); M.M.J. Stevens (Marc)

    2017-01-01

    textabstractWe introduce a new efficient algorithm for computing Groebner-bases named M4GB. Like Faugere's algorithm F4 it is an extension of Buchberger's algorithm that describes: how to store already computed (tail-)reduced multiples of basis polynomials to prevent redundant work in the reduction

  18. Technical basis document for external events

    OBERG, B.D.

    2003-01-01

    This document supports the Tank Farms Documented Safety Analysis and presents the technical basis for the FR-equencies of externally initiated accidents. The consequences of externally initiated events are discussed in other documents that correspond to the accident that was caused by the external event. The external events include aircraft crash, vehicle accident, range fire, and rail accident

  19. PRELIMINARY SELECTION OF MGR DESIGN BASIS EVENTS

    Kappes, J.A.

    1999-01-01

    The purpose of this analysis is to identify the preliminary design basis events (DBEs) for consideration in the design of the Monitored Geologic Repository (MGR). For external events and natural phenomena (e.g., earthquake), the objective is to identify those initiating events that the MGR will be designed to withstand. Design criteria will ensure that radiological release scenarios resulting from these initiating events are beyond design basis (i.e., have a scenario frequency less than once per million years). For internal (i.e., human-induced and random equipment failures) events, the objective is to identify credible event sequences that result in bounding radiological releases. These sequences will be used to establish the design basis criteria for MGR structures, systems, and components (SSCs) design basis criteria in order to prevent or mitigate radiological releases. The safety strategy presented in this analysis for preventing or mitigating DBEs is based on the preclosure safety strategy outlined in ''Strategy to Mitigate Preclosure Offsite Exposure'' (CRWMS M andO 1998f). DBE analysis is necessary to provide feedback and requirements to the design process, and also to demonstrate compliance with proposed 10 CFR 63 (Dyer 1999b) requirements. DBE analysis is also required to identify and classify the SSCs that are important to safety (ITS)

  20. 340 waste handling facility interim safety basis

    VAIL, T.S.

    1999-04-01

    This document presents an interim safety basis for the 340 Waste Handling Facility classifying the 340 Facility as a Hazard Category 3 facility. The hazard analysis quantifies the operating safety envelop for this facility and demonstrates that the facility can be operated without a significant threat to onsite or offsite people.

  1. The Biological Basis of Learning and Individuality.

    Kandel, Eric R.; Hawkins, Robert D.

    1992-01-01

    Describes the biological basis of learning and individuality. Presents an overview of recent discoveries that suggest learning engages a simple set of rules that modify the strength of connection between neurons in the brain. The changes are cited as playing an important role in making each individual unique. (MCO)

  2. The neurocognitive basis of feature integration

    Keizer, André Willem

    2010-01-01

    One of the most striking features of the brain is that it is modular; it consists of often highly specialized areas. This modular organization requires efficient communication in order to integrate the information that is represented in distinct brain areas. In my thesis, I studied the neural basis

  3. The molecular basis of peanut allergy

    Peanut allergens can trigger a potent and sometimes dangerous immune response in an increasing number of people. The molecular structures of these allergens form the basis for understanding this response. This review describes the currently known peanut allergen structures, and discusses how modif...

  4. An evolutionary basis for pollination ecology

    Willemstein, S.C.

    1987-01-01

    In the introduction and chapter 2 the incentives and way of reasoning are given for the description of an evolutionary basis of pollination ecology. Starting from the until recently rather anecdotical character of the study of pollination ecology as a whole, and in the absence of large-scale

  5. 340 waste handling facility interim safety basis

    VAIL, T.S.

    1999-01-01

    This document presents an interim safety basis for the 340 Waste Handling Facility classifying the 340 Facility as a Hazard Category 3 facility. The hazard analysis quantifies the operating safety envelop for this facility and demonstrates that the facility can be operated without a significant threat to onsite or offsite people

  6. The Emotional and Moral Basis of Rationality

    Boostrom, Robert

    2013-01-01

    This chapter explores the basis of rationality, arguing that critical thinking tends to be taught in schools as a set of skills because of the failure to recognize that choosing to think critically depends on the prior development of stable sentiments or moral habits that nourish a rational self. Primary among these stable sentiments are the…

  7. Fundamentals of futures, options, basis and derivatives

    Jones, D.

    1997-01-01

    Characteristic features of futures and options contracts, basis differentials and derivatives were defined and explained. A futures contract refers to an exchange-traded supply contract between a buyer and a seller where the buyer is obligated to take delivery and the seller is obligated to provide delivery of a fixed amount of a commodity at a predetermined price at a specified location. In contrast, an option contract gives the purchaser the right, but not the obligation, to buy or sell the underlying commodity at a certain price on or before an agreed date. Basis differential refers to the discount between two distinct delivery points to reflect the relative value of a commodity, such as natural gas, at those points. Advantages and disadvantages of futures and options contacts, the factors affecting options pricing, and basis differentials, and the methods of calculating basis differentials were described. The nature and intricacies of derivatives, their benefits, in particular their use as a tool for the effective management of the volatilities associated with the oil and gas industry were explained. Their shortcomings such as the high liquidity risk, were also described. Examples of derivative transactions were provided to illustrate the interrelationships of futures/options/derivatives, and their role in financial risk management

  8. Some considerations about Gaussian basis sets for electric property calculations

    Arruda, Priscilla M.; Canal Neto, A.; Jorge, F. E.

    Recently, segmented contracted basis sets of double, triple, and quadruple zeta valence quality plus polarization functions (XZP, X = D, T, and Q, respectively) for the atoms from H to Ar were reported. In this work, with the objective of having a better description of polarizabilities, the QZP set was augmented with diffuse (s and p symmetries) and polarization (p, d, f, and g symmetries) functions that were chosen to maximize the mean dipole polarizability at the UHF and UMP2 levels, respectively. At the HF and B3LYP levels of theory, electric dipole moment and static polarizability for a sample of molecules were evaluated. Comparison with experimental data and results obtained with a similar size basis set, whose diffuse functions were optimized for the ground state energy of the anion, was done.

  9. Rationalization of foundry processes on the basis of simulation experiment

    S. Kukla

    2008-10-01

    Full Text Available The paper presents results of research obtained on the basis of simulation experiment, whose aim was to analyze the performance of cast iron foundry. A simulation model of automobile industry foundry was made. The course of the following processes was analyzedin a computer model: preparation of liquid cast iron, forming and filling the moulds, cooling and stamping the castings, cleaning andfinishing treatment. The sheets of multi-criterion evaluation were prepared, where criteria and variants were assessed by meansof subjective point evaluation and fuzzy character evaluation. The paper presents an analysis example of finishing activities of castings realized in foundry on traditional machines and efficient presses and in cooperation. On the basis of reports from a simulation experiment information was achieved related to activities’ duration, load of accessible resources, the problems of storage and transport, bottle necks in the system and appearing queues in from of workplaces. The research used a universal modelling and simulation packet for productionsystems - ARENA.

  10. Ultrasound beam transmission using a discretely orthogonal Gaussian aperture basis

    Roberts, R. A.

    2018-04-01

    Work is reported on development of a computational model for ultrasound beam transmission at an arbitrary geometry transmission interface for generally anisotropic materials. The work addresses problems encountered when the fundamental assumptions of ray theory do not hold, thereby introducing errors into ray-theory-based transmission models. Specifically, problems occur when the asymptotic integral analysis underlying ray theory encounters multiple stationary phase points in close proximity, due to focusing caused by concavity on either the entry surface or a material slowness surface. The approach presented here projects integrands over both the transducer aperture and the entry surface beam footprint onto a Gaussian-derived basis set, thereby distributing the integral over a summation of second-order phase integrals which are amenable to single stationary phase point analysis. Significantly, convergence is assured provided a sufficiently fine distribution of basis functions is used.

  11. Epidemiologic measures of risk as a basis for legal compensation

    Zeighami, E.A.; Walsh, P.J.; Morris, M.D.; Jones, T.D.

    1983-01-01

    The scientific basis for compensation of persons developing cancer who have a documented history of exposure to radiation or other carcinogens is an important legal issue. The measure Relative Attributable Risk (RAR) has been proposed as a basis for determining eligibility for compensation. The purpose of this report is to present results of an analysis of the magnitude and sources of uncertainty in the RAR measure. The range of 1/10 6 /rad-year to 6/10 6 /rad-year was chosen as a reasonable range of excess-risk estimates for thyroid cancer based on published estimates. The use of such a range in risk estimates produces very wide variability in RAR estimates. Uncertainty in underlying incidence levels and in dosimetry are other major factors contributing to large variability in estimated RAR levels

  12. Technical Details on Beyond Design Basis Event Pilot Evaluations

    None, None

    2013-01-01

    The primary focus of the BDBE pilot project was the review of BDBE analysis and mitigation features at four DOE nuclear facilities representing a range of DOE sites, nuclear facility types/activities, and responsible program offices. The pilots looked at (1) how beyond design basis accidents were evaluated and documented in the facility Documented Safety Analysis, (2) potential BDBE vulnerabilities and margins to failure of facility safety features as obtained from general area and specific system walkdowns and design documents reviews, and (3) preparations made in facility and site emergency management programs to respond to severe accidents. It also evaluated whether draft BDBE guidance on safety analysis and emergency management could be used to improve the analysis of and preparations for mitigating severe and beyond design basis accidents. The details of these activities are organized in this report as described below.

  13. System Design and the Safety Basis

    Ellingson, Darrel

    2008-01-01

    The objective of this paper is to present the Bechtel Jacobs Company, LLC (BJC) Lessons Learned for system design as it relates to safety basis documentation. BJC has had to reconcile incomplete or outdated system description information with current facility safety basis for a number of situations in recent months. This paper has relevance in multiple topical areas including documented safety analysis, decontamination and decommissioning (D and D), safety basis (SB) implementation, safety and design integration, potential inadequacy of the safety analysis (PISA), technical safety requirements (TSR), and unreviewed safety questions. BJC learned that nuclear safety compliance relies on adequate and well documented system design information. A number of PIS As and TSR violations occurred due to inadequate or erroneous system design information. As a corrective action, BJC assessed the occurrences caused by systems design-safety basis interface problems. Safety systems reviewed included the Molten Salt Reactor Experiment (MSRE) Fluorination System, K-1065 fire alarm system, and the K-25 Radiation Criticality Accident Alarm System. The conclusion was that an inadequate knowledge of system design could result in continuous non-compliance issues relating to nuclear safety. This was especially true with older facilities that lacked current as-built drawings coupled with the loss of 'historical knowledge' as personnel retired or moved on in their careers. Walkdown of systems and the updating of drawings are imperative for nuclear safety compliance. System design integration with safety basis has relevance in the Department of Energy (DOE) complex. This paper presents the BJC Lessons Learned in this area. It will be of benefit to DOE contractors that manage and operate an aging population of nuclear facilities

  14. Cold Vacuum Drying facility design basis accident analysis documentation

    CROWE, R.D.

    2000-01-01

    This document provides the detailed accident analysis to support HNF-3553, Annex B, Spent Nuclear Fuel Project Final Safety Analysis Report (FSAR), ''Cold Vacuum Drying Facility Final Safety Analysis Report.'' All assumptions, parameters, and models used to provide the analysis of the design basis accidents are documented to support the conclusions in the FSAR. The calculations in this document address the design basis accidents (DBAs) selected for analysis in HNF-3553, ''Spent Nuclear Fuel Project Final Safety Analysis Report'', Annex B, ''Cold Vacuum Drying Facility Final Safety Analysis Report.'' The objective is to determine the quantity of radioactive particulate available for release at any point during processing at the Cold Vacuum Drying Facility (CVDF) and to use that quantity to determine the amount of radioactive material released during the DBAs. The radioactive material released is used to determine dose consequences to receptors at four locations, and the dose consequences are compared with the appropriate evaluation guidelines and release limits to ascertain the need for preventive and mitigative controls

  15. Cold Vacuum Drying facility design basis accident analysis documentation

    CROWE, R.D.

    2000-08-08

    This document provides the detailed accident analysis to support HNF-3553, Annex B, Spent Nuclear Fuel Project Final Safety Analysis Report (FSAR), ''Cold Vacuum Drying Facility Final Safety Analysis Report.'' All assumptions, parameters, and models used to provide the analysis of the design basis accidents are documented to support the conclusions in the FSAR. The calculations in this document address the design basis accidents (DBAs) selected for analysis in HNF-3553, ''Spent Nuclear Fuel Project Final Safety Analysis Report'', Annex B, ''Cold Vacuum Drying Facility Final Safety Analysis Report.'' The objective is to determine the quantity of radioactive particulate available for release at any point during processing at the Cold Vacuum Drying Facility (CVDF) and to use that quantity to determine the amount of radioactive material released during the DBAs. The radioactive material released is used to determine dose consequences to receptors at four locations, and the dose consequences are compared with the appropriate evaluation guidelines and release limits to ascertain the need for preventive and mitigative controls.

  16. Experimental investigations on the basis for intellectual property rights.

    Fast, Anne A; Olson, Kristina R; Mandel, Gregory N

    2016-08-01

    Lay people routinely misunderstand or do not obey laws protecting intellectual property (IP), leading to a variety of (largely unsuccessful) efforts by policymakers, IP owners, and researchers to change those beliefs and behaviors. The current work tests a new approach, inquiring whether lay people's views about IP protection can be modified by arguments concerning the basis for IP rights. Across 2 experiments, 572 adults (recruited through Amazon Mechanical Turk) read 1 of 6 arguments about the basis for IP protection (incentives, natural rights, expressive rights, plagiarism, commons, or no argument). Participants then reported their general support for IP protection. Participants also reported their evaluations of 2 scenarios that involved infringement of IP rights, including cases in which there were mitigating experiences (e.g., the copier acknowledged the original source), and completed several demographic questions. Three primary findings emerged: (a) exposure to the importance of the public commons (and to a lesser extent, exposure to the argument that plagiarism is the basis of IP protection) led participants to become less supportive of IP protection than the incentives, natural rights, expressive rights, and control conditions; (b) people believed that infringement was more acceptable if the infringer acknowledged the original creator of the work; and (c) older adults and women were especially likely to see infringement as problematic. These findings illustrate several ways in which lay beliefs are at odds with legal doctrine, and suggest that people's views about IP protection can be shaped in certain ways by learning the basis for IP rights. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  17. Organic solvent topical report

    Cowley, W.L.

    1998-04-30

    This report is the technical basis for the accident and consequence analyses used in the Hanford Tank Farms Basis for Interim Operation. The report also contains the scientific and engineering information and reference material needed to understand the organic solvent safety issue. This report includes comments received from the Chemical Reactions Subcommittee of the Tank Advisory Panel.

  18. Organic solvent topical report

    Cowley, W.L.

    1998-01-01

    This report is the technical basis for the accident and consequence analyses used in the Hanford Tank Farms Basis for Interim Operation. The report also contains the scientific and engineering information and reference material needed to understand the organic solvent safety issue. This report includes comments received from the Chemical Reactions Subcommittee of the Tank Advisory Panel

  19. Selection of design basis event for modular high temperature gas-cooled reactor

    Sato, Hiroyuki; Nakagawa, Shigeaki; Ohashi, Hirofumi

    2016-06-01

    Japan Atomic Energy Agency (JAEA) has been investigating safety requirements and basic approach of safety guidelines for modular High Temperature Gas-cooled Reactor (HTGR) aiming to increase internarial contribution for nuclear safety by developing an international HTGR safety standard under International Atomic Energy Agency. In this study, we investigate a deterministic approach to select design basis events utilizing information obtained from probabilistic approach. In addition, selections of design basis events are conducted for commercial HTGR designed by JAEA. As a result, an approach for selecting design basis event considering multiple failures of safety systems is established which has not been considered as design basis in the safety guideline for existing nuclear facility. Furthermore, selection of design basis events for commercial HTGR has completed. This report provides an approach and procedure for selecting design basis events of modular HTGR as well as selected events for the commercial HTGR, GTHTR300. (author)

  20. Radioactive Waste Management BasisApril 2006

    Perkins, B K

    2011-08-31

    This Radioactive Waste Management Basis (RWMB) documents radioactive waste management practices adopted at Lawrence Livermore National Laboratory (LLNL) pursuant to Department of Energy (DOE) Order 435.1, Radioactive Waste Management. The purpose of this Radioactive Waste Management Basis is to describe the systematic approach for planning, executing, and evaluating the management of radioactive waste at LLNL. The implementation of this document will ensure that waste management activities at LLNL are conducted in compliance with the requirements of DOE Order 435.1, Radioactive Waste Management, and the Implementation Guide for DOE Manual 435.1-1, Radioactive Waste Management Manual. Technical justification is provided where methods for meeting the requirements of DOE Order 435.1 deviate from the DOE Manual 435.1-1 and Implementation Guide.

  1. TECHNICAL BASIS DOCUMENT FOR NATURAL EVENT HAZARDS

    KRIPPS, L.J.

    2006-01-01

    This technical basis document was developed to support the documented safety analysis (DSA) and describes the risk binning process and the technical basis for assigning risk bins for natural event hazard (NEH)-initiated accidents. The purpose of the risk binning process is to determine the need for safety-significant structures, systems, and components (SSC) and technical safety requirement (TSR)-level controls for a given representative accident or represented hazardous conditions based on an evaluation of the frequency and consequence. Note that the risk binning process is not applied to facility workers, because all facility worker hazardous conditions are considered for safety-significant SSCs and/or TSR-level controls

  2. Basis of valve operator selection for SMART

    Kang, H. S.; Lee, D. J.; See, J. K.; Park, C. K.; Choi, B. S.

    2000-05-01

    SMART, an integral reactor with enhanced safety and operability, is under development for use of the nuclear energy. The valve operator of SMART system were selected through the data survey and technical review of potential valve fabrication vendors, and it will provide the establishment and optimization of the basic system design of SMART. In order to establish and optimize the basic system design of SMART, the basis of selection for the valve operator type were provided based on the basic design requirements. The basis of valve operator selection for SMART will be used as a basic technical data for the SMART basic and detail design and a fundamental material for the new reactor development in the future

  3. Accelerating GW calculations with optimal polarizability basis

    Umari, P.; Stenuit, G. [CNR-IOM DEMOCRITOS Theory Elettra Group, Basovizza (Trieste) (Italy); Qian, X.; Marzari, N. [Department of Materials Science and Engineering, MIT, Cambridge, MA (United States); Giacomazzi, L.; Baroni, S. [CNR-IOM DEMOCRITOS Theory Elettra Group, Basovizza (Trieste) (Italy); SISSA - Scuola Internazionale Superiore di Studi Avanzati, Trieste (Italy)

    2011-03-15

    We present a method for accelerating GW quasi-particle (QP) calculations. This is achieved through the introduction of optimal basis sets for representing polarizability matrices. First the real-space products of Wannier like orbitals are constructed and then optimal basis sets are obtained through singular value decomposition. Our method is validated by calculating the vertical ionization energies of the benzene molecule and the band structure of crystalline silicon. Its potentialities are illustrated by calculating the QP spectrum of a model structure of vitreous silica. Finally, we apply our method for studying the electronic structure properties of a model of quasi-stoichiometric amorphous silicon nitride and of its point defects. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  4. Doubly stochastic radial basis function methods

    Yang, Fenglian; Yan, Liang; Ling, Leevan

    2018-06-01

    We propose a doubly stochastic radial basis function (DSRBF) method for function recoveries. Instead of a constant, we treat the RBF shape parameters as stochastic variables whose distribution were determined by a stochastic leave-one-out cross validation (LOOCV) estimation. A careful operation count is provided in order to determine the ranges of all the parameters in our methods. The overhead cost for setting up the proposed DSRBF method is O (n2) for function recovery problems with n basis. Numerical experiments confirm that the proposed method not only outperforms constant shape parameter formulation (in terms of accuracy with comparable computational cost) but also the optimal LOOCV formulation (in terms of both accuracy and computational cost).

  5. Basis of valve operator selection for SMART

    Kang, H. S.; Lee, D. J.; See, J. K.; Park, C. K.; Choi, B. S

    2000-05-01

    SMART, an integral reactor with enhanced safety and operability, is under development for use of the nuclear energy. The valve operator of SMART system were selected through the data survey and technical review of potential valve fabrication vendors, and it will provide the establishment and optimization of the basic system design of SMART. In order to establish and optimize the basic system design of SMART, the basis of selection for the valve operator type were provided based on the basic design requirements. The basis of valve operator selection for SMART will be used as a basic technical data for the SMART basic and detail design and a fundamental material for the new reactor development in the future.

  6. Conceptual basis for the european sustainability footprint

    PELLETIER NATHANIEL; MAAS Rob; GORALCZYK MALGORZATA; WOLF Marc-Andree

    2012-01-01

    Sustainability is central to the policy objectives of the European Commission (EC), but a widely accepted integrated sustainability assessment framework in support of policy analysis and development is currently lacking. Here, we describe the conceptual basis for the proposed European Sustainability Footprint (ESF) - an integrated sustainability assessment framework for establishing a baseline and tracking trends with respect to the sustainability of European production and consumption. This ...

  7. Basis of the nuclear magnetic resonance

    Bahceli, S.

    1996-08-01

    The aim of this book which is translated from English language is to explain the physical and mathematical basis of nuclear magnetic resonance (NMR). There are nine chapters covering different aspects of NMR. In the firs chapter fundamental concepts of quantum mechanics are given at a level suitable for readers to understand NMR fully. The remaining chapters discuss the magnetic properties of nucleus, the interactions between atoms and molecules, continuous wave NMR, pulsed NMR, nuclear magnetic relaxation and NMR of liquids

  8. The basis spline method and associated techniques

    Bottcher, C.; Strayer, M.R.

    1989-01-01

    We outline the Basis Spline and Collocation methods for the solution of Partial Differential Equations. Particular attention is paid to the theory of errors, and the handling of non-self-adjoint problems which are generated by the collocation method. We discuss applications to Poisson's equation, the Dirac equation, and the calculation of bound and continuum states of atomic and nuclear systems. 12 refs., 6 figs

  9. Thermodynamic basis for effective energy utilization

    Rogers, J. T.

    1977-10-15

    A major difficulty in a quantitative assessment of effective energy utilization is that energy is always conserved (the First Law of Thermodynamics). However, the Second Law of Thermodynamics shows that, although energy cannot be destroyed, it can be degraded to a state in which it is of no further use for performing tasks. Thus, in considering the present world energy crisis, we are not really concerned with the conservation of energy but with the conservation of its ability to perform useful tasks. A measure of this ability is thermodynamic availability or, a less familiar term, exergy. In a real sense, we are concerned with an entropy-crisis, rather than an energy crisis. Analysis of energy processes on an exergy basis provides significantly different insights into the processes than those obtained from a conventional energy analysis. For example, process steam generation in an industrial boiler may appear quite efficient on the basis of a conventional analysis, but is shown to have very low effective use of energy when analyzed on an exergy basis. Applications of exergy analysis to other systems, such as large fossil and nuclear power stations, are discussed, and the benefits of extraction combined-purpose plants are demonstrated. Other examples of the application of the exergy concept in the industrial and residential energy sectors are also given. The concept is readily adaptable to economic optimization. Examples are given of economic optimization on an availability basis of an industrial heat exchanger and of a combined-purpose nuclear power and heavy-water production plant. Finally, the utility of the concept of exergy in assessing the energy requirements of an industrial society is discussed.

  10. Learning Methods for Radial Basis Functions Networks

    Neruda, Roman; Kudová, Petra

    2005-01-01

    Roč. 21, - (2005), s. 1131-1142 ISSN 0167-739X R&D Projects: GA ČR GP201/03/P163; GA ČR GA201/02/0428 Institutional research plan: CEZ:AV0Z10300504 Keywords : radial basis function networks * hybrid supervised learning * genetic algorithms * benchmarking Subject RIV: BA - General Mathematics Impact factor: 0.555, year: 2005

  11. Establishing 'design basis threat' in Norway

    Maerli, M.B.; Naadland, E.; Reistad, O.

    2002-01-01

    Full text: INFCIRC 225 (Rev. 4) assumes that a state's physical protection system should be based on the state's evaluation of the threat, and that this should be reflected in the relevant legislation. Other factors should also be considered, including the state's emergency response capabilities and the existing and relevant measures of the state's system of accounting for and control of nuclear material. A design basis threat developed from an evaluation by the state of the threat of unauthorized removal of nuclear material and of sabotage of nuclear material and nuclear facilities is an essential element of a state's system of physical protection. The state should continuously review the threat, and evaluate the implications of any changes in that threat for the required levels and the methods of physical protection. As part of a national design basis threat assessment, this paper evaluates the risk of nuclear or radiological terrorism and sabotage in Norway. Possible scenarios are presented and plausible consequences are discussed with a view to characterize the risks. The need for more stringent regulatory requirements will be discussed, together with the (positive) impact of improved systems and procedures of physical protection on nuclear emergency planning. Special emphasis is placed on discussing the design basis threat for different scenarios in order to systemize regulatory efforts to update the current legislation, requirement for operators' contingency planning, response efforts and the need for emergency exercises. (author)

  12. Feasibility studies for final disposal of low and intermediate radioactive waste - summary with main conclusions and recommendations from three parallel studies. Report to the cross-departmental working group for preparing a decision basis for establishing a Danish radioactive waste disposal facility; Forstudier til slutdepot for lav- og mellemaktivt affald - sammendrag indeholdende hovedkonklusionerne og anbefalinger fra tre parallelle studier. Rapport til den tvaerministerielle arbejdsgruppe vedr. udarbejdelse af beslutningsgrundlag med henblik paa etablering af et dansk slutdepot for lav- og mellemaktivt affald

    2011-05-15

    In 2003, the Danish Parliament in resolution No. B 48 on the dismantling of the nuclear facilities at Risoe gave consent to the government to begin preparation of a decision basis for a Danish final repository for low and intermediate level waste. As a result, a working group under the Ministry of Health and Prevention in 2008 prepared the report 'Decision basis for a Danish final repository for low and medium level radioactive waste'. In this report it was recommended to prepare three parallel preliminary studies: one about the repository concepts with the aim to obtain the necessary decision-making basis for selecting which concepts to analyze within the process of establishing a final repository, one on transportation of radioactive waste to the depot and one about regional mapping with the aim to characterize areas as suitable or unsuitable for locating a repository. The present report contains the main conclusions of each of the three parallel studies in relation to the further localization process. The preliminary studies suggest 22 areas, of which it is recommended to proceed with six in the selection process. The preliminary studies also show that all investigated storage concepts will be possible solutions from a security standpoint. However, there will be greater risks associated with depots near the surface, because they are more subjected to intentional or accidental intrusion. Overall, a medium deep repository will be the most appropriate solution, but it is also a more expensive solution than the near-surface repository. Both subsurface and the deep repositories may be reversible, but it is estimated to increase overall costs and may increase risk related to accidents. The preliminary studies establishes a set of conclusions and recommendations concerning future studies related to repository concepts and safety analyses, including in relation to the specific geology at the selected locations. The transportation studies show that radio

  13. A risk-informed framework for establishing a beyond design basis safety basis for external hazards

    Amico, P. [Hughes Associates, Inc, Baltimore, MD (United States); Anoba, R. [Hughes Associates, Inc, Raleigh, NC (United States); Najafi, B. [Hughes Associates, Inc., Los Gatos, CA (United States)

    2014-07-01

    The events at Fukushima Daiichi taught us that meeting a deterministic design basis requirement for external hazards does not assure that the risk is low. As observed at the plant, the two primary reasons for this are failure cliffs above the design basis event and that combined hazard effects are not considered in design. Because the possible combinations of design basis exceedences and external hazard combinations are very large and complex, an approach focusing only on the most important ones is needed. For this reason, a risk informed approach is the most effective approach, which is discussed in this paper. (author)

  14. Technical Basis for Electromagnetic Compatibility Regulatory Guidance Update

    Ewing, Paul D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Korsah, Kofi [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Harrison, Thomas J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wood, Richard Thomas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mays, Gary T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-03-01

    The objective of this report is to serve as the technical basis document for the next, planned revision of this RG that highlights and provides the rationale for the recommended changes. The structure of this document follows and summarizes the several assessment activities undertaken during the course of this project to evaluate new and updated electromagnetic compatibility (EMC) standards, testing methods and limits, and relevant technology developments being incorporated into plant activities that may have EMI/RFI implications, as well as other specific issues, including impacts of electrostatic discharge (ESD) on safety equipment and impacts on increased usage of wireless devices in nuclear power plants.

  15. Evolution of Safety Basis Documentation for the Fernald Site

    Brown, T.; Kohler, S.; Fisk, P.; Krach, F.; Klein, B.

    2004-01-01

    The objective of the Department of Energy's (DOE) Fernald Closure Project (FCP), in suburban Cincinnati, Ohio, is to safely complete the environmental restoration of the Fernald site by 2006. Over 200 out of 220 total structures, at this DOE plant site which processed uranium ore concentrates into high-purity uranium metal products, have been safely demolished, including eight of the nine major production plants. Documented Safety Analyses (DSAs) for these facilities have gone through a process of simplification, from individual operating Safety Analysis Reports (SARs) to a single site-wide Authorization Basis containing nuclear facility Bases for Interim Operations (BIOs) to individual project Auditable Safety Records (ASRs). The final stage in DSA simplification consists of project-specific Integrated Health and Safety Plans (I-HASPs) and Nuclear Health and Safety Plans (N-HASPs) that address all aspects of safety, from the worker in the field to the safety basis requirements preserving the facility/activity hazard categorization. This paper addresses the evolution of Safety Basis Documentation (SBD), as DSAs, from production through site closure

  16. Central waste complex interim safety basis

    Cain, F.G.

    1995-01-01

    This interim safety basis provides the necessary information to conclude that hazards at the Central Waste Complex are controlled and that current and planned activities at the CWC can be conducted safely. CWC is a multi-facility complex within the Solid Waste Management Complex that receives and stores most of the solid wastes generated and received at the Hanford Site. The solid wastes that will be handled at CWC include both currently stored and newly generated low-level waste, low-level mixed waste, contact-handled transuranic, and contact-handled TRU mixed waste

  17. Sense Training as Basis for Aesthetic Experience

    Thomsen, Bente Dahl

    2016-01-01

    . It is a special problem for design engineers, who must guarantee the aesthetic, ethical and utilitarian qualities of products in a product development process. It does not matter whether they or other designers have conceived the product idea. It has been found that sense training can open up to aesthetic...... and train their specification of the basis for aesthetic experiences. The context for the study is a course and a project in interaction design about designing rehabilitation products, where undergraduate students must develop a project program with focus on theoretical scientific research and experiment...

  18. The inherited basis of human radiosensitivity

    Gatti, R.A.

    2001-01-01

    Certain individuals cannot tolerate 'conventional' doses of radiation therapy. This is known to be true of patients with ataxia-telangiectasia and ligase IV deficiency. Although in vitro testing may not correlate completely with clinical radiosensitivity, fibroblasts and lymphoblasts from patients with both of these disorders have been clearly shown to be radiosensitive. Using a colony survival assay (CSA) to test lymphoblastoid cells after irradiation with 1 Gy, a variety of other genetic disorders have been identified as strong candidates for clinical radiosensitivity, such as Nijmegen breakage syndrome, Mre11 deficiency, and Fanconi's anemia. These data are presented and considered as a starting-point for the inherited basis of human radiosensitivity

  19. [Basis for designing a medical course curriculum].

    Villarreal, R; Bojalil, L F; Mercer, H

    1977-01-01

    This article sets forth the reasons for the structure given to the Division of Biology and Health on the Xochimilco campus of Metropolitan Autonomous University in Mexico: to adjust the university to the process of social change going forward in the country and gear the university to the problems of the present by avoiding the rigidity of its structure. The basic aspects of curriculum design are cited against a background of an historical analysis of the socioeconomic structure of education and health. The principles underlying the curriculum and the course work are then described on the basis of that analysis.

  20. The generative basis of natural number concepts.

    Leslie, Alan M; Gelman, Rochel; Gallistel, C R

    2008-06-01

    Number concepts must support arithmetic inference. Using this principle, it can be argued that the integer concept of exactly ONE is a necessary part of the psychological foundations of number, as is the notion of the exact equality - that is, perfect substitutability. The inability to support reasoning involving exact equality is a shortcoming in current theories about the development of numerical reasoning. A simple innate basis for the natural number concepts can be proposed that embodies the arithmetic principle, supports exact equality and also enables computational compatibility with real- or rational-valued mental magnitudes.

  1. Neuroanatomical basis for recognition primed decision making.

    Hudson, Darren

    2013-01-01

    Effective decision making under time constraints is often overlooked in medical decision making. The recognition primed decision making (RPDM) model was developed by Gary Klein based on previous recognized situations to develop a satisfactory solution to the current problem. Bayes Theorem is the most popular decision making model in medicine but is limited by the need for adequate time to consider all probabilities. Unlike other decision making models, there is a potential neurobiological basis for RPDM. This model has significant implication for health informatics and medical education.

  2. Basis of the biological decomposition of xenobiotica

    Mueller, R. von

    1993-01-01

    The ability of micro-organisms to decompose different molecules and to use them as a source of carbon, nitrogen, sulphur or energy is the basis for all biological processes for cleaning up contaminated soil. Therefore, the knowledge of these decomposition processes is an important precondition for judging which contamination can be treated biologically at all and which materials can be decomposed biologically. The decomposition schemes of the most important harmful material classes (aliphatic, aromatic and chlorinated hydrocarbons) are introduced and the consequences which arise for the practical application in biological cleaning up of contaminated soils are discussed. (orig.) [de

  3. Conductance calculations with a wavelet basis set

    Thygesen, Kristian Sommer; Bollinger, Mikkel; Jacobsen, Karsten Wedel

    2003-01-01

    We present a method based on density functional theory (DFT) for calculating the conductance of a phase-coherent system. The metallic contacts and the central region where the electron scattering occurs, are treated on the same footing taking their full atomic and electronic structure into account....... The linear-response conductance is calculated from the Green's function which is represented in terms of a system-independent basis set containing wavelets with compact support. This allows us to rigorously separate the central region from the contacts and to test for convergence in a systematic way...

  4. Basis for calculations in the topological expansion

    Levinson, M.A.

    1982-12-01

    Investigations aimed at putting the topological theory of particles on a more quantitative basis are described. First, the incorporation of spin into the topological structure is discussed and shown to successfully reproduce the observed lowest mass hadron spectrum. The absence of parity-doubled states represents a significant improvement over previous efforts in similar directions. This theory is applied to the lowest order calculation of elementary hadron coupling constant ratios. SU(6)/sub W/ symmetry is maintained and extended via the notions of topological supersymmetry and universality. Finally, efforts to discover a perturbative basis for the topological expansion are described. This has led to the formulation of off-shell Feynman-like rules which provide a calculational scheme for the strong interaction components of the topological expansion once the zero-entropy connected parts are known. These rules are shown to imply a topological asymptotic freedom. Even though the nonlinear zero-entropy problem cannot itself be treated perturbatively, plausible general assumptions about zero-entropy amplitudes allow immediate qualitative inferences concerning physical hadrons. In particular, scenarios for mass splittings beyond the supersymmetric level are described

  5. Spherical radial basis functions, theory and applications

    Hubbert, Simon; Morton, Tanya M

    2015-01-01

    This book is the first to be devoted to the theory and applications of spherical (radial) basis functions (SBFs), which is rapidly emerging as one of the most promising techniques for solving problems where approximations are needed on the surface of a sphere. The aim of the book is to provide enough theoretical and practical details for the reader to be able to implement the SBF methods to solve real world problems. The authors stress the close connection between the theory of SBFs and that of the more well-known family of radial basis functions (RBFs), which are well-established tools for solving approximation theory problems on more general domains. The unique solvability of the SBF interpolation method for data fitting problems is established and an in-depth investigation of its accuracy is provided. Two chapters are devoted to partial differential equations (PDEs). One deals with the practical implementation of an SBF-based solution to an elliptic PDE and another which describes an SBF approach for solvi...

  6. Fast radial basis functions for engineering applications

    Biancolini, Marco Evangelos

    2017-01-01

    This book presents the first “How To” guide to the use of radial basis functions (RBF). It provides a clear vision of their potential, an overview of ready-for-use computational tools and precise guidelines to implement new engineering applications of RBF. Radial basis functions (RBF) are a mathematical tool mature enough for useful engineering applications. Their mathematical foundation is well established and the tool has proven to be effective in many fields, as the mathematical framework can be adapted in several ways. A candidate application can be faced considering the features of RBF:  multidimensional space (including 2D and 3D), numerous radial functions available, global and compact support, interpolation/regression. This great flexibility makes RBF attractive – and their great potential has only been partially discovered. This is because of the difficulty in taking a first step toward RBF as they are not commonly part of engineers’ cultural background, but also due to the numerical complex...

  7. Technical Basis for PNNL Beryllium Inventory

    Johnson, Michelle Lynn

    2014-07-09

    The Department of Energy (DOE) issued Title 10 of the Code of Federal Regulations Part 850, “Chronic Beryllium Disease Prevention Program” (the Beryllium Rule) in 1999 and required full compliance by no later than January 7, 2002. The Beryllium Rule requires the development of a baseline beryllium inventory of the locations of beryllium operations and other locations of potential beryllium contamination at DOE facilities. The baseline beryllium inventory is also required to identify workers exposed or potentially exposed to beryllium at those locations. Prior to DOE issuing 10 CFR 850, Pacific Northwest Nuclear Laboratory (PNNL) had documented the beryllium characterization and worker exposure potential for multiple facilities in compliance with DOE’s 1997 Notice 440.1, “Interim Chronic Beryllium Disease.” After DOE’s issuance of 10 CFR 850, PNNL developed an implementation plan to be compliant by 2002. In 2014, an internal self-assessment (ITS #E-00748) of PNNL’s Chronic Beryllium Disease Prevention Program (CBDPP) identified several deficiencies. One deficiency is that the technical basis for establishing the baseline beryllium inventory when the Beryllium Rule was implemented was either not documented or not retrievable. In addition, the beryllium inventory itself had not been adequately documented and maintained since PNNL established its own CBDPP, separate from Hanford Site’s program. This document reconstructs PNNL’s baseline beryllium inventory as it would have existed when it achieved compliance with the Beryllium Rule in 2001 and provides the technical basis for the baseline beryllium inventory.

  8. Archaeological data as a basis for repository marker design

    Kaplan, M.F.

    1982-10-01

    This report concerns the development of a marking system for a nuclear waste repository which is very likely to survive for 10,000 years. In order to provide a background on the subject, and for the preliminary design presented in this report, a discussion is presented about the issues involved in human interference with the repository system and the communication of information. A separate chapter summarizes six ancient man-made monuments including: materials, effects of associated textual information on our understanding of the monument, and other features of the ancient monument relevant to marking a repository site. The information presented in the two chapters is used to provide the basis and rationale for a preliminary marker system design presented in a final chapter. 86 refs., 22 figs., 1 tab

  9. Archaeological data as a basis for repository marker design

    Kaplan, M.F.

    1982-10-01

    This report concerns the development of a marking system for a nuclear waste repository which is very likely to survive for 10,000 years. In order to provide a background on the subject, and for the preliminary design presented in this report, a discussion is presented about the issues involved in human interference with the repository system and the communication of information. A separate chapter summarizes six ancient man-made monuments including: materials, effects of associated textual information on our understanding of the monument, and other features of the ancient monument relevant to marking a repository site. The information presented in the two chapters is used to provide the basis and rationale for a preliminary marker system design presented in a final chapter. 86 refs., 22 figs., 1 tab.

  10. Aircraft Research Guideline 1999 - 2002: High pressure compressor - preliminary design as a basis for the development of an efficient and environmentally friendly core engine. Final report; Leitlinie Luftfahrtforschung 1999 - 2002: Hochdruckverdichter-Vorauslegung als Grundlagenuntersuchung zur Entwicklung eines Kerntriebwerkes fuer einen effizienten und umweltfreundlichen Antrieb. Schlussbericht

    Klinger, H.

    2001-08-01

    This report completes the documentation for the research project 'High Pressure Compressor - Preliminary Design as Basis for the Development of an Efficient and Environmentally Friendly Core Engine' which was funded by the Ministry of Economics of State Brandenburg. The objective of the project is to deliver a preliminary compressor aerodynamic design as well as design studies for an efficient, weight and cost improved compressor. The increase of stage pressure ratio and improved efficiency, whilst stage and blade count is reduced, has been achieved by advanced 3D methods. Compressor stability also at off-design conditions will be retained. The mechanical design focusses on a cost and weight optimised rotor not only for a conventional bladed discs but also for Blish stages. Various options for split casings have been developed and assessed. Alternative vortex reducers based on different design options have been carried out. The results from this project will be directly exploited in a follow-on project for a new nine-stage compressor. The new high pressure compressor will be a key element of the future two-shaft-engine architecture. (orig.) [German] Der vorliegende Bericht schliesst das vom Land Brandenburg im Rahmen der Leitlinie Luftfahrtforschung gefoerderte Vorhaben 'Hochdruckverdichter - Vorauslegung als Grundlagenuntersuchung zur Entwicklung eines Kerntriebwerkes fuer einen effizienten und umweltfreundlichen Antrieb' ab. Ziel dieses Vorhabens ist es, im Rahmen einer aerodynamischen Vorauslegung sowie Designstudien die notwendigen Technologien zu erarbeiten, um einen hinsichtlich Effizienz, Kosten, Gewicht und Wartungsintervallen verbesserten Hochdruckverdichter auszulegen. Die Erhoehung des Druckverhaeltnisses und des Wirkungsgrads bei verringerter Stufen- und Schaufelzahl sowie ein stabiles Betriebsverhalten auch ausserhalb des Auslegungspunktes wurde dabei durch eine aeusserst fortschrittliche 3D Schaufelauslegung erreicht. Auf der

  11. A Scientific Basis for Climate Policy

    2007-08-01

    The Scientific Council on Climate Issues has been commissioned by the Swedish Government to provide a scientific assessment as a basis for the work of the Climate Committee, the all-party committee for the review of climate policy. An important part of this task is to provide a basis and recommendations for Swedish climate policy targets at national, EU and international level. In the opening chapters, the Council looks at climate change, its reasons and its consequences for ecosystems and society. The Council then makes recommendations concerning Swedish climate policy targets at global, EU and national levels, aimed at averting dangerous impact on the climate. In the concluding chapters, the Council presents a number of possible measures and policy instruments, and outlines the likely costs involved if the goals are to be achieved. Taken as a whole, the document represents a comprehensive basis for policy decisions that consider what needs to be achieved to reduce the risks of climate impact and what is actually achievable, i.e. decisions involving trade-offs between economic benefits and costs. The Council considers: that the EU's GHG emissions compared to the 1990 level should be reduced by 30-40 % by 2020 and by 75-90 % by 2050 if the Union is to take its share of the global responsibility for achievement of the two-degree target; that Sweden's GHG emissions compared to the 1990 level should be reduced by 20-25 % by 2020 and by 70-85 % by 2050 if Sweden is to take its share of the global responsibility for achievement of the two-degree target; that a national emission target for Sweden should be formulated as a target with deductible emissions allowances, i.e., that assessment of target achievement is based on the amount of emission allowances allocated or auctioned by Sweden to activities covered by the EU emissions trading scheme rather than the actual volume of emissions from these activities. The Council has provided an overview of possible measures for

  12. Localifecation of variable-basis topological systems | Solovyov ...

    The paper provides another approach to the notion of variable-basis topological system generalizing the fixed-basis concept of S. Vickers, considers functorial relationships between the categories of modified variable-basis topological systems and variable-basis fuzzy topological spaces in the sense of S.E. Rodabaugh ...

  13. Acceptable risk as a basis for design

    Vrijling, J.K.; Hengel, W. van; Houben, R.J.

    1998-01-01

    Historically, human civilisations have striven to protect themselves against natural and man-made hazards. The degree of protection is a matter of political choice. Today this choice should be expressed in terms of risk and acceptable probability of failure to form the basis of the probabilistic design of the protection. It is additionally argued that the choice for a certain technology and the connected risk is made in a cost-benefit framework. The benefits and the costs including risk are weighed in the decision process. A set of rules for the evaluation of risk is proposed and tested in cases. The set of rules leads to technical advice in a question that has to be decided politically

  14. Configuration management after design basis reconstitution

    Purcell, J.J.; Livingston, B.R.

    1991-01-01

    Over the last few years, Fort Calhoun station (FCS) has implemented a number of programs to enhance plant operability and readiness. The design basis document (DBD) reconstitution project was the cornerstone of this effort. Vendor manual upgrade, operating procedures upgrade, plant equipment data-base verification, equipment labeling, and warehousing improvements were also implemented as part of this improvement program. With the completion of these programs, plant documentation was current to the baselines established by each program, and a configuration management program (CMP) was established to maintain this level of accuracy throughout the remaining life of FCS. Change control throughout the organization has been reviewed and upgraded to ensure that all changes are evaluated for impact to the design bases

  15. The scientific basis for patient blood management.

    Murphy, M F; Goodnough, L T

    2015-08-01

    Patient blood management is an increasingly used term to describe an evidence-based, multidisciplinary approach to optimising the care of patients who might need transfusion. It encompasses measures to avoid transfusion such as anaemia management without transfusion, cell salvage and the use of anti-fibrinolytic drugs to reduce bleeding as well as restrictive transfusion. It ensures that patients receive the optimal treatment, and that avoidable, inappropriate use of blood and blood components is reduced. This paper provides an overview of the scientific basis for patient blood management with a focus on the increasing evidence for restrictive rather than liberal transfusion practice and the use of electronic blood ordering and decision support to facilitate its implementation. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  16. Technical Basis Document (TBD) and user guides

    Chiaro, P.J. Jr.

    1998-09-01

    A Technical Basis Document (TBD) should provide the background information for establishment of an instrument's operational requirements. Due to the amount and location of DOE facilities, no one set of requirements is possible. Operational requirements will vary based on the local environments and missions at each facility. Environmental conditions that can affect an instrument's operations are ambient temperature, humidity, and radio frequency, and to a lesser extent, magnetic fields, and interfering ionizing radiations. Consideration should also be made regarding how an instrument is to be used. If an instrument will be transported around the facility, vibration and shock can cause problems if they are not addressed in the TBD. This document provides guidance for the development of a TBD. This document applies to radiation instruments used for personnel and equipment contamination monitoring, dose rate monitoring, and air monitoring

  17. Radioactive Waste Management BasisSept 2001

    Goodwin, S.S.

    2011-01-01

    This Radioactive Waste Management Basis (RWMB) documents radioactive waste management practices adopted at Lawrence Livermore National Laboratory (LLNL) pursuant to Department of Energy (DOE) Order 435.1, Radioactive Waste Management. The purpose of this RWMB is to describe the systematic approach for planning, executing, and evaluating the management of radioactive waste at LLNL. The implementation of this document will ensure that waste management activities at LLNL are conducted in compliance with the requirements of DOE Order 435.1, Radioactive Waste Management, and the Implementation Guide for DOE manual 435.1-1, Radioactive Waste Management Manual. Technical justification is provided where methods for meeeting the requirements of DOE Order 435.1 deviate from the DOE Manual 435.1-1 and Implementation Guide.

  18. The inherited basis of human radiosensitivity

    Gatti, R.A. [Univ. of California, School of Medicine, Los Angeles, CA (United States). Experimental Pathology

    2001-11-01

    Certain individuals cannot tolerate 'conventional' doses of radiation therapy. This is known to be true of patients with ataxia-telangiectasia and ligase IV deficiency. Although in vitro testing may not correlate completely with clinical radiosensitivity, fibroblasts and lymphoblasts from patients with both of these disorders have been clearly shown to be radiosensitive. Using a colony survival assay (CSA) to test lymphoblastoid cells after irradiation with 1 Gy, a variety of other genetic disorders have been identified as strong candidates for clinical radiosensitivity, such as Nijmegen breakage syndrome, Mre11 deficiency, and Fanconi's anemia. These data are presented and considered as a starting-point for the inherited basis of human radiosensitivity.

  19. Prototype Hanford Surface Barrier: Design basis document

    Myers, D.R.; Duranceau, D.A.

    1994-11-01

    The Hanford Site Surface Barrier Development Program (BDP) was organized in 1985 to develop the technology needed to provide a long-term surface barrier capability for the Hanford Site and other arid sites. This document provides the basis of the prototype barrier. Engineers and scientists have momentarily frozen evolving barrier designs and incorporated the latest findings from BDP tasks. The design and construction of the prototype barrier has required that all of the various components of the barrier be brought together into an integrated system. This integration is particularly important because some of the components of the protective barreir have been developed independently of other barreir components. This document serves as the baseline by which future modifications or other barrier designs can be compared. Also, this document contains the minutes of meeting convened during the definitive design process in which critical decisions affecting the prototype barrier's design were made and the construction drawings

  20. Scoliosis angle. Conceptual basis and proposed definition

    Marklund, T [Linkoepings Hoegskola (Sweden)

    1978-01-01

    The most commonly used methods of assessing the scoliotic deviation measure angles that are not clearly defined in relation to the anatomy of the patient. In order to give an anatomic basis for such measurements it is proposed to define the scoliotic deviation as the deviation the vertebral column makes with the sagittal plane. Both the Cobb and the Ferguson angles may be based on this definition. The present methods of measurement are then attempts to measure these angles. If the plane of these angles is parallel to the film, the measurement will be correct. Errors in the measurements may be incurred by the projection. A hypothetical projection, called a 'rectified orthogonal projection', is presented, which correctly represents all scoliotic angles in accordance with these principles. It can be constructed in practice with the aid of a computer and by performing measurements on two projections of the vertebral column; a scoliotic curve can be represented independent of the kyphosis and lordosis.

  1. Design Load Basis for Offshore Wind turbines

    Natarajan, Anand; Hansen, Morten Hartvig; Wang, Shaofeng

    2016-01-01

    DTU Wind Energy is not designing and manufacturing wind turbines and does therefore not need a Design Load Basis (DLB) that is accepted by a certification body. However, to assess the load consequences of innovative features and devices added to existing offshore turbine concepts or new offshore...... turbine concept developed in our research, it is useful to have a full DLB that follows the current design standard and is representative of a general DLB used by the industry. It will set a standard for the offshore wind turbine design load evaluations performed at DTU Wind Energy, which is aligned...... with the challenges faced by the industry and therefore ensures that our research continues to have a strong foundation in this interaction. Furthermore, the use of a full DLB that follows the current standard can improve and increase the feedback from the research at DTU Wind Energy to the international...

  2. Physics basis of ITER-FEAT

    Shimada, M.; Campbell, D.J.; Wakatani, M.; Ninomiya, H.; Ivanov, N.V.; Mukhovatov, V.

    2001-01-01

    This paper reviews Physics R and D results obtained since the publication of the ITER Physics Basis document. The heating power required for the LH transition has been re-assessed, including recent results from C-Mod and JT-60U and it has been found that the predicted power is a factor of two lower than the previous projection. For predicting ITER-FEAT performance, a conservative scaling IPB98(y,2) has been adopted for the energy confinement, producing confinement times ∼20% lower than those derived from the IPB98(y,1) law. While energy confinement degradation at high density remains a serious issue, recent experiments suggest that good confinement is achievable in ITER at n/n G ∼0.85 with high triangularity. The estimated runaway electron energy has been reduced to ∼20MJ, since recent experiments show that runaway electrons disappear for q 95 leq2. (author)

  3. The Metabolic Basis of Kidney Cancer

    Linehan, W. Marston; Ricketts, Christopher J.

    2012-01-01

    Kidney cancer is not a single disease; it is made up of a number of different types of cancer that occur in the kidney. Each of these different types of kidney cancer can have a different histology, have a different clinical course, can respond differently to therapy and is caused by a different gene. Kidney cancer is essentially a metabolic disease; each of the known genes for kidney cancer, VHL, MET, FLCN, TSC1, TSC2, TFE3, TFEB, MITF, fumarate hydratase (FH), succinate dehydrogenase B (SDHB), succinate dehydrogenase D (SDHD), and PTEN genes is involved in the cells ability to sense oxygen, iron, nutrients or energy. Understanding the metabolic basis of kidney cancer will hopefully provide the foundation for the development of effective forms of therapy for this disease. PMID:22705279

  4. Biochemical Basis of Sestrin Physiological Activities

    Ho, Allison; Cho, Chun-Seok; Namkoong, Sim; Cho, Uhn-Soo; Lee, Jun Hee (Michigan)

    2016-05-10

    Excessive accumulation of reactive oxygen species (ROS) and chronic activation of mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) are well-characterized promoters of aging and age-associated degenerative pathologies. Sestrins, a family of highly conserved stress-inducible proteins, are important negative regulators of both ROS and mTORC1 signaling pathways; however, the mechanistic basis of how Sestrins suppress these pathways remains elusive. In the past couple of years, breakthrough discoveries about Sestrin signaling and its molecular nature have markedly increased our biochemical understanding of Sestrin function. These discoveries have also uncovered new potential therapeutic strategies that may eventually enable us to attenuate aging and age-associated diseases.

  5. Corporate Finance: its organization and epistemological basis

    Luiz Henrique Herling

    2014-08-01

    Full Text Available This study aims to show how they are organized studies in financial management and what is the paradigm that support the theories presented until today, contextualizing how financial management is organized within the science of Directors in historical and evolutionary terms . Based on the decisions of the financial manager of investment , financing and operations , the study seeks to show that the philosophical basis that supports the theories developed . Yet for better understanding separates financial management in personal finance , financial markets and corporate finance , the latter being the main focus of the study . In the literature we can divide and stratify studies in corporate finance for a better understanding . By analyzing under an evolutionary approach notes a growing chains in other studies in finance , such as public finance, behavioral finance and here called green finance.

  6. Technical basis document for internal dosimetry

    Hickman, D P

    1991-01-01

    This document provides the technical basis for the Chem-Nuclear Geotech (Geotech) internal dosimetry program. Geotech policy describes the intentions of the company in complying with radiation protection standards and the as low as reasonably achievable (ALARA) program. It uses this policy and applicable protection standards to derive acceptable methods and levels of bioassay to assure compliance. The models and computational methods used are described in detail within this document. FR-om these models, dose- conversion factors and derived limits are computed. These computations are then verified using existing documentation and verification information or by demonstration of the calculations used to obtain the dose-conversion factors and derived limits. Recommendations for methods of optimizing the internal dosimetry program to provide effective monitoring and dose assessment for workers are provided in the last section of this document. This document is intended to be used in establishing an accredited dosi...

  7. Nuclear energy - basis for hydrogen economy

    Gyoshev, G.

    2004-01-01

    The development of human civilization in general as well as that of every country in particular is in direct relation to the assurance of a cost effective energy balance encompassing all industrial spheres and everyday activities. Unfortunately, the uncontrolled utilization of Earth's energy resources is already causing irreversible damage to various components of the eco-system of the Earth. Nuclear energy used for electricity and hydrogen production has the biggest technological potential for solving of the main energy outstanding issues of the new century: increasing of energy dependence; global warming. Because of good market position the political basis is assured for fast development of new generation nuclear reactors and fuel cycles which can satisfy vigorously increasing needs of affordable and clean energy. Political conditions are created for adequate participation of nuclear energy in the future global energy mix. They must give chance to the nuclear industry to take adequate part in the new energy generation capacity.(author)

  8. Mentoring as the basis for social business

    Artcer Tatiana

    2016-01-01

    Full Text Available In this article the concept of mentoring as a basis for social business is considered. Besides, the ways of increase of efficiency of labor use through the institute of mentoring of young workers are considered by elderly people. Features of employment, work and dismissal of aging employees are also considered. Possibilities of application of mentoring, attraction of experience of pensioners taking into account the high level of their qualification are reflected. Tasks which the institute of mentoring will help to solve are formulated. The article examines the possibility of using mentoring and engaging retired employees with their experience, a high level of their education and professional qualification in the training of young inexperienced workers. Mentoring is presented as an element of social entrepreneurship.

  9. Physiological Basis for Prompt Health Effects

    VINCENT, Andrew

    2006-01-01

    As input to design considerations precluding worker radiological exposure that could lead to an acute health effect from a postulated accident condition, an assessment of the short term health effects was performed. To assure that the impact of the accident scenario on the individual is appropriately considered, both external and internal exposures are included in the evaluation. The focus of this evaluation was to develop a quantitative basis from which to consider the level of exposure postulated in an accident that could lead to a defined physiological impact for short term health effects. This paper does not assess latent health effects of radiological exposure associated with normal operations or emergency response guidelines as these are clearly articulated in existing regulations and ICRP documents. The intent of this paper is to facilitate a dialogue on the appropriate meaning of currently undefined terms such as ''significant'' exposure and ''high-hazard material'' in DSA development

  10. NUUK BASIC: The BioBasis programme

    Bay, Christian; Nymand, Josephine; Aastrup, Peter

    2013-01-01

    The 2011 season was the fourth full season for the BioBasis monitoring programme. Generally, there is a high consistency in data collected during the four years indicating that the data and the procedures used are reliable and sound. A preliminary review of data related to fl owering and plant...... in the beginning of the growing season presumably due to the late snow melt. Generally, all plots functioned as sinks for atmospheric CO2 in August and September, whereas fl uxes were close to zero in June, July and October. Similar to earlier years NEE (Net Ecosystem Exchange) is more negative in C-plots (control...... of gross primary production were generally observed in C-plots, while especially S-plots showed lower GPP (Gross Primary Production) rates compared with other treatments. In general, there are huge variations in the number of trapped arthropod specimen within all taxonomical groups both within the season...

  11. Safeguards agreements - Their legal and conceptual basis

    Sanders, B.; Rainer, R.H.

    1977-01-01

    The application of Agency safeguards requires treaty arrangements (Safeguards Agreements) between the State or States concerned and the Agency. The authority for the Agency to conclude such agreements and to implement them is provided for in the Agency's Statute. On the basis of the statutory provisions safeguards principles and procedures have been elaborated. These have been laid down in: The Agency's Safeguards System 1965, extended in 1966 and 1968; and the basis for negotiating safeguards agreements with NNWS pursuant to NPT. The verification of the undertaking by the State concerned not to use items subject to safeguards for purposes contrary to the terms of the agreement is ensured through the application of various safeguards measures. Containment and surveillance measures are expected to play an increasingly important role. One of the specific features of NPT Safeguards Agreements is the establishment of national systems of accounting and control of nuclear material. The majority of the agreements concluded under the non-NPT safeguards agreements implement obligations undertaken under co-operation agreements between States for peaceful uses of nuclear energy. These agreements naturally reflect approaches adopted by the parties, in particular regarding the circumstances under which safeguards should be applied. Thus, the concepts used in the non-NPT safeguards agreements and the Safeguards System document, which is incorporated in these agreements by reference, are in continuous evolution. The Agency's Safeguards System document (INFCIRC/66/Rev.2) continues to be supplemented in practical application and through explicit decision by the Board. The non-NPT safeguards agreements contain, besides technical safeguards provisions from this document, and further provision for notification, inventories and financial matters, legal and political provisions such as sanctions in the case of non-compliance, and privileges and immunities. The paper discusses the

  12. Safety basis for selected activities in single-shell tanks with flammable gas concerns. Revision 1

    Schlosser, R.L.

    1996-01-01

    This is full revision to Revision 0 of this report. The purpose of this report is to provide a summary of analyses done to support activities performed for single-shell tanks. These activities are encompassed by the flammable gas Unreviewed Safety Question (USQ). The basic controls required to perform these activities involve the identification, elimination and/or control of ignition sources and monitoring for flammable gases. Controls are implemented through the Interim Safety Basis (ISB), IOSRs, and OSDs. Since this report only provides a historical compendium of issues and activities, it is not to be used as a basis to perform USQ screenings and evaluations. Furthermore, these analyses and others in process will be used as the basis for developing the Flammable Gas Topical Report for the ISB Upgrade

  13. Spent Nuclear Fuel (SNF) Project Design Basis Capacity Study

    CLEVELAND, K.J.

    2000-01-01

    This study of the design basis capacity of process systems was prepared by Fluor Federal Services for the Spent Nuclear Fuel Project. The evaluation uses a summary level model of major process sub-systems to determine the impact of sub-system interactions on the overall time to complete fuel removal operations. The process system model configuration and time cycle estimates developed in the original version of this report have been updated as operating scenario assumptions evolve. The initial document released in Fiscal Year (FY) 1996 varied the number of parallel systems and transport systems over a wide range, estimating a conservative design basis for completing fuel processing in a two year time period. Configurations modeling planned operations were updated in FY 1998 and FY 1999. The FY 1998 Base Case continued to indicate that fuel removal activities at the basins could be completed in slightly over 2 years. Evaluations completed in FY 1999 were based on schedule modifications that delayed the start of KE Basin fuel removal, with respect to the start of KW Basin fuel removal activities, by 12 months. This delay resulted in extending the time to complete all fuel removal activities by 12 months. However, the results indicated that the number of Cold Vacuum Drying (CVD) stations could be reduced from four to three without impacting the projected time to complete fuel removal activities. This update of the design basis capacity evaluation, performed for FY 2000, evaluates a fuel removal scenario that delays the start of KE Basin activities such that staffing peaks are minimized. The number of CVD stations included in all cases for the FY 2000 evaluation is reduced from three to two, since the scenario schedule results in minimal time periods of simultaneous fuel removal from both basins. The FY 2000 evaluation also considers removal of Shippingport fuel from T Plant storage and transfer to the Canister Storage Building for storage

  14. Mixing of incompatible materials in waste tanks technical basis document

    SANDGREN, K.R.

    2003-01-01

    This technical basis document was developed to support the Tank Farms Documented Safety Analysis (DSA) and describes the risk binning process, the technical basis for assigning risk bins, and the controls selected for the mixing of incompatible materials representative accident and associated represented hazardous conditions. The purpose of the risk binning process is to determine the need for safety-significant structures, systems, and components (SSCs) and/or technical safety requirement (TSR)-level controls for a given representative accident or represented hazardous conditions based on an evaluation of the FR-equency and consequence. Note that the risk binning process is not applied to facility workers, because all facility worker hazardous conditions are considered for safety-significant SSCs and/or TSR level controls. Determination of the need for safety-class SSCs was performed in accordance with DOE-STD-3009-94, ''Preparation Guide for US Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses'', as described in this report

  15. Advanced Fuel Cycle Cost Basis – 2017 Edition

    Dixon, B. W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ganda, F. [Argonne National Lab. (ANL), Argonne, IL (United States); Williams, K. A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hoffman, E. [Argonne National Lab. (ANL), Argonne, IL (United States); Hanson, J. K. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-09-29

    This report, commissioned by the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), provides a comprehensive set of cost data supporting a cost analysis for the relative economic comparison of options for use in the DOE Nuclear Technology Research and Development (NTRD) Program (previously the Fuel Cycle Research and Development (FCRD) and the Advanced Fuel Cycle Initiative (AFCI)). The report describes the NTRD cost basis development process, reference information on NTRD cost modules, a procedure for estimating fuel cycle costs, economic evaluation guidelines, and a discussion on the integration of cost data into economic computer models. This report contains reference cost data for numerous fuel cycle cost modules (modules A-O) as well as cost modules for a number of reactor types (R modules). The fuel cycle cost modules were developed in the areas of natural uranium mining and milling, thorium mining and milling, conversion, enrichment, depleted uranium disposition, fuel fabrication, interim spent fuel storage, reprocessing, waste conditioning, spent nuclear fuel (SNF) packaging, long-term monitored retrievable storage, managed decay storage, recycled product storage, near surface disposal of low-level waste (LLW), geologic repository and other disposal concepts, and transportation processes for nuclear fuel, LLW, SNF, transuranic, and high-level waste. Since its inception, this report has been periodically updated. The last such internal document was published in August 2015 while the last external edition was published in December of 2009 as INL/EXT-07-12107 and is available on the Web at URL: www.inl.gov/technicalpublications/Documents/4536700.pdf. This current report (Sept 2017) is planned to be reviewed for external release, at which time it will replace the 2009 report as an external publication. This information is used in the ongoing evaluation of nuclear fuel cycles by the NE NTRD program.

  16. Defining meridians: a modern basis of understanding.

    Longhurst, John C

    2010-06-01

    Acupuncture, one of the primary methods of treatment in traditional Oriental medicine, is based on a system of meridians. Along the meridians lie acupuncture points or acupoints, which are stimulated by needling, pressure or heat to resolve a clinical problem. A number of methods have been used to identify meridians and to explain them anatomically. Thus, tendinomuscular structures, primo-vessels (Bonghan ducts), regions of increased temperature and low skin resistance have been suggested to represent meridians or as methods to identify them. However, none of these methods have met the criteria for a meridian, an entity that, when stimulated by acupuncture can result in clinical improvement. More recently, modern physiologists have put forward the "neural hypothesis" stating that the clinical influence of acupuncture is transmitted primarily through stimulation of sensory nerves that provide signals to the brain, which processes this information and then causes clinical changes associated with treatment. Although additional research is warranted to investigate the role of some of the structures identified, it seems clear that the peripheral and central nervous system can now be considered to be the most rational basis for defining meridians. The meridian maps and associated acupoints located along them are best viewed as road maps that can guide practitioners towards applying acupuncture to achieve optimal clinical results. Copyright 2010 Korean Pharmacopuncture Institute. Published by .. All rights reserved.

  17. Framing effects: behavioral dynamics and neural basis.

    Zheng, Hongming; Wang, X T; Zhu, Liqi

    2010-09-01

    This study examined the neural basis of framing effects using life-death decision problems framed either positively in terms of lives saved or negatively in terms of lives lost in large group and small group contexts. Using functional MRI we found differential brain activations to the verbal and social cues embedded in the choice problems. In large group contexts, framing effects were significant where participants were more risk seeking under the negative (loss) framing than under the positive (gain) framing. This behavioral difference in risk preference was mainly regulated by the activation in the right inferior frontal gyrus, including the homologue of the Broca's area. In contrast, framing effects diminished in small group contexts while the insula and parietal lobe in the right hemisphere were distinctively activated, suggesting an important role of emotion in switching choice preference from an indecisive mode to a more consistent risk-taking inclination, governed by a kith-and-kin decision rationality. Copyright 2010 Elsevier Ltd. All rights reserved.

  18. The molecular basis of lactose intolerance.

    Campbell, Anthony K; Waud, Jonathan P; Matthews, Stephanie B

    2009-01-01

    A staggering 4000 million people cannot digest lactose, the sugar in milk, properly. All mammals, apart from white Northern Europeans and few tribes in Africa and Asia, lose most of their lactase, the enzyme that cleaves lactose into galactose and glucose, after weaning. Lactose intolerance causes gut and a range of systemic symptoms, though the threshold to lactose varies considerably between ethnic groups and individuals within a group. The molecular basis of inherited hypolactasia has yet to be identified, though two polymorphisms in the introns of a helicase upstream from the lactase gene correlate closely with hypolactasia, and thus lactose intolerance. The symptoms of lactose intolerance are caused by gases and toxins produced by anaerobic bacteria in the large intestine. Bacterial toxins may play a key role in several other diseases, such as diabetes, rheumatoid arthritis, multiple sclerosis and some cancers. The problem of lactose intolerance has been exacerbated because of the addition of products containing lactose to various foods and drinks without being on the label. Lactose intolerance fits exactly the illness that Charles Darwin suffered from for over 40 years, and yet was never diagnosed. Darwin missed something else--the key to our own evolution--the Rubicon some 300 million years ago that produced lactose and lactase in sufficient amounts to be susceptible to natural selection.

  19. Design basis II: Design for events

    Frisch, W.

    1982-01-01

    In a lecture of this title, it could be expected that all events which are a basis for system and component design are described. According to the title of the Course 'Instrumentation and Control of Nuclear Power Plants' emphasis is put on events originating within the plant (no consideration of external events such as air plane crash or earth-quake). The lecture is divided into the two parts 'Transients' and 'Loss of coolant accidents (LOCAs)'. Due to the complex interaction between systems and components during transients, the first part is the main part of the lecture, while the second part (LOCAs) is only a very brief description of emergency core cooling system functions and the typical course of a large and small LOCA event. The first part on anticipated transients with intact primary coolant system boundary (non-LOCA-transients) covers several aspects of the analysis, such as classification, brief system description, transient description, analysis of anticipated transients without scram (ATWS) and analytical methods. Due to the time restriction necessary within the course, only a small section of the entire area can be presented in this paper. (orig.)

  20. Metabolic syndrome: clinical concept and molecular basis.

    Funahashi, Tohru; Matsuzawa, Yuji

    2007-01-01

    The metabolic syndrome is a cluster of insulin resistance, elevated blood pressure, and atherogenic dyslipidemia and is a common basis of cardiovascular diseases (CVD). Although the precise mechanism remains to be elucidated, a practical definition is needed. A worldwide definition that considers increased waist circumference as an essential component has been settled. Visceral fat locates upstream of the liver. Free fatty acids and glycerol derived from visceral fat reach the liver and stimulate lipoprotein synthesis and gluconeogenesis, respectively. The adipose tissue produces a variety of bioactive substances conceptualized as 'adipocytokines'. Overproduction of plasminogen activator inhibitor-1 and tumor necrosis factor- seems to relate to the thrombotic and inflammatory tendency. On the other hand, adiponectin, which has antiatherogenic and antidiabetic activities, is reduced in subjects with metabolic syndrome. In Japan, the waist circumference criterion based on visceral fat accumulation has been adopted. The concept of this syndrome has been widely publicized, and health promotion programs based on the concept have commenced in various areas of the country. Such 'Adipo-Do-It' movement is an incentive to encourage physical exercise to reduce visceral fat and is a big challenge to prevent life-style-related diseases and CVD.

  1. The neural basis of monitoring goal progress

    Yael eBenn

    2014-09-01

    Full Text Available The neural basis of progress monitoring has received relatively little attention compared to other sub-processes that are involved in goal directed behavior such as motor control and response inhibition. Studies of error-monitoring have identified the dorsal anterior cingulate cortex (dACC as a structure that is sensitive to conflict detection, and triggers corrective action. However, monitoring goal progress involves monitoring correct as well as erroneous events over a period of time. In the present research, 20 healthy participants underwent fMRI while playing a game that involved monitoring progress towards either a numerical or a visuo-spatial target. The findings confirmed the role of the dACC in detecting situations in which the current state may conflict with the desired state, but also revealed activations in the frontal and parietal regions, pointing to the involvement of processes such as attention and working memory in monitoring progress over time. In addition, activation of the cuneus was associated with monitoring progress towards a specific target presented in the visual modality. This is the first time that activation in this region has been linked to higher-order processing of goal-relevant information, rather than low-level anticipation of visual stimuli. Taken together, these findings identify the neural substrates involved in monitoring progress over time, and how these extend beyond activations observed in conflict and error monitoring.

  2. Overview of physics basis for ITER

    Mukhovatov, V; Shimada, M; Chudnovskiy, A N; Costley, A E; Gribov, Y; Federici, G; Kardaun, O; Kukushkin, A S; Polevoi, A; Pustovitov, V D; Shimomura, Y; Sugie, T; Sugihara, M; Vayakis, G

    2003-01-01

    ITER will be the first magnetic confinement device with burning DT plasma and fusion power of about 0.5 GW. Parameters of ITER plasma have been predicted using methodologies summarized in the ITER Physics Basis (1999 Nucl. Fusion 39 2175). During the past few years, new results have been obtained that substantiate confidence in achieving Q>=10 in ITER with inductive H-mode operation. These include achievement of a good H-mode confinement near the Greenwald density at high triangularity of the plasma cross section; improvements in theory-based confinement projections for the core plasma, even though further studies are needed for understanding the transport near the plasma edge; improvement in helium ash removal due to the elastic collisions of He atoms with D/T ions in the divertor predicted by modelling; demonstration of feedback control of neoclassical tearing modes and resultant improvement in the achievable beta values; better understanding of edge localized mode (ELM) physics and development of ELM mitigation techniques; and demonstration of mitigation of plasma disruptions. ITER will have a flexibility to operate also in steady-state and intermediate (hybrid) regimes. The 'advanced tokamak' regimes with weak or negative central magnetic shear and internal transport barriers are considered as potential scenarios for steady-state operation. The paper concentrates on inductively driven plasma performance and discusses requirements for steady-state operation in ITER

  3. The neural basis of the imitation drive.

    Hanawa, Sugiko; Sugiura, Motoaki; Nozawa, Takayuki; Kotozaki, Yuka; Yomogida, Yukihito; Ihara, Mizuki; Akimoto, Yoritaka; Thyreau, Benjamin; Izumi, Shinichi; Kawashima, Ryuta

    2016-01-01

    Spontaneous imitation is assumed to underlie the acquisition of important skills by infants, including language and social interaction. In this study, functional magnetic resonance imaging (fMRI) was used to examine the neural basis of 'spontaneously' driven imitation, which has not yet been fully investigated. Healthy participants were presented with movie clips of meaningless bimanual actions and instructed to observe and imitate them during an fMRI scan. The participants were subsequently shown the movie clips again and asked to evaluate the strength of their 'urge to imitate' (Urge) for each action. We searched for cortical areas where the degree of activation positively correlated with Urge scores; significant positive correlations were observed in the right supplementary motor area (SMA) and bilateral midcingulate cortex (MCC) under the imitation condition. These areas were not explained by explicit reasons for imitation or the kinematic characteristics of the actions. Previous studies performed in monkeys and humans have implicated the SMA and MCC/caudal cingulate zone in voluntary actions. This study also confirmed the functional connectivity between Urge and imitation performance using a psychophysiological interaction analysis. Thus, our findings reveal the critical neural components that underlie spontaneous imitation and provide possible reasons why infants imitate spontaneously. © The Author (2015). Published by Oxford University Press.

  4. Interim Basis for PCB Sampling and Analyses

    BANNING, D.L.

    2001-01-01

    This document was developed as an interim basis for sampling and analysis of polychlorinated biphenyls (PCBs) and will be used until a formal data quality objective (DQO) document is prepared and approved. On August 31, 2000, the Framework Agreement for Management of Polychlorinated Biphenyls (PCBs) in Hanford Tank Waste was signed by the US. Department of Energy (DOE), the Environmental Protection Agency (EPA), and the Washington State Department of Ecology (Ecology) (Ecology et al. 2000). This agreement outlines the management of double shell tank (DST) waste as Toxic Substance Control Act (TSCA) PCB remediation waste based on a risk-based disposal approval option per Title 40 of the Code of Federal Regulations 761.61 (c). The agreement calls for ''Quantification of PCBs in DSTs, single shell tanks (SSTs), and incoming waste to ensure that the vitrification plant and other ancillary facilities PCB waste acceptance limits and the requirements of the anticipated risk-based disposal approval are met.'' Waste samples will be analyzed for PCBs to satisfy this requirement. This document describes the DQO process undertaken to assure appropriate data will be collected to support management of PCBs and is presented in a DQO format. The DQO process was implemented in accordance with the U.S. Environmental Protection Agency EPA QAlG4, Guidance for the Data Quality Objectives Process (EPA 1994) and the Data Quality Objectives for Sampling and Analyses, HNF-IP-0842/Rev.1 A, Vol. IV, Section 4.16 (Banning 1999)

  5. Technical basis document for internal dosimetry

    Hickman, D.P.

    1991-01-01

    This document provides the technical basis for the Chem-Nuclear Geotech (Geotech) internal dosimetry program. Geotech policy describes the intentions of the company in complying with radiation protection standards and the as low as reasonably achievable (ALARA) program. It uses this policy and applicable protection standards to derive acceptable methods and levels of bioassay to assure compliance. The models and computational methods used are described in detail within this document. FR-om these models, dose- conversion factors and derived limits are computed. These computations are then verified using existing documentation and verification information or by demonstration of the calculations used to obtain the dose-conversion factors and derived limits. Recommendations for methods of optimizing the internal dosimetry program to provide effective monitoring and dose assessment for workers are provided in the last section of this document. This document is intended to be used in establishing an accredited dosimetry program in accordance with expected Department of Energy Laboratory Accreditation Program (DOELAP) requirements for the selected radionuclides provided in this document, including uranium mill tailing mixtures. Additions and modifications to this document and procedures derived FR-om this document are expected in the future according to changes in standards and changes in programmatic mission

  6. Electromagnetic Basis of Metabolism and Heredity

    Freund, Friedemann; Stolc, Viktor

    2016-01-01

    Living organisms control their cellular biological clocks to maintain functional oscillation of the redox cycle, also called the "metabolic cycle" or "respiratory cycle". Organization of cellular processes requires parallel processing on a synchronized time-base. These clocks coordinate the timing of all biochemical processes in the cell, including energy production, DNA replication, and RNA transcription. When this universal time keeping function is perturbed by exogenous induction of reactive oxygen species (ROS), the rate of metabolism changes. This causes oxidative stress, aging and mutations. Therefore, good temporal coordination of the redox cycle not only actively prevents chemical conflict between the reductive and oxidative partial reactions; it also maintains genome integrity and lifespan. Moreover, this universal biochemical rhythm can be disrupted by ROS induction in vivo. This in turn can be achieved by blocking the electron transport chain either endogenously or exogenously by various metabolites, e.g. hydrogen sulfide (H2S), highly diffusible drugs, and carbon monoxide (CO). Alternatively, the electron transport in vivo can be attenuated via a coherent or interfering transfer of energy from exogenous ultralow frequency (ULF) and extremely low frequency (ELF) electromagnetic (EM) fields, suggesting that-on Earth-such ambient fields are an omnipresent (and probably crucially important) factor for the time-setting basis of universal biochemical reactions in living cells. Our work demonstrated previously un-described evidence for quantum effects in biology by electromagnetic coupling below thermal noise at the universal electron transport chain (ETC) in vivo.

  7. Proprioception as a basis for individual differences

    Liutsko, Ludmila N.

    2013-09-01

    Full Text Available In this chapter the author summarises the descriptions of proprioceptive sense from different perspectives. The importance of proprioceptive sense has been shown in developmental psychology, in both the earlier and later stages of individuum formation. The author emphasises in this chapter the role of proprioception as a basis of personality and the individual differences construct. The importance of assessing behaviour at multiple levels has been pointed out by experiments of classic and modern researchers that should include not only verbal tests that would be more important for conscious mental description, but also techniques that could assess other behavioural characteristics, including automatic unconscious and pre-reflexive behaviour. The author also describes the effects of altered proprioception in humans, such as the Pinocchio effect, and other spatial perception distortions. In this chapter the importance of proprioception in acquiring new skills (embodied knowledge as automatic and conditioned reflexive behaviour has also been highlighted. Finally, the complete picture of the individuum has been presented as a multi-layered level of a body-mind union approach.

  8. Social enterprise: theoretical basis and perespectives

    Julian Narlev

    2017-07-01

    Full Text Available Since the 1980s the issues of social enterprises have gained particular popularity, practical and applied, as well as scientific significance. For a short period of time - almost half a century - social enterprises have become an integral part of education and academic research; they have turned into factors affecting noticeably the social and economic policy. The formation and development of social enterprises are the consequence of the profound social, demographic, cultural, global and public changes - the result of capitalism and its cornerstone, the enterprise. This contemporary and innovative theory is a natural extension of the strategies for change in societies and the world - both globally, and in response to the non-profit, public and business sectors - in an attempt to solve the topical and important issues of the time. In view of the circumstances given above, the present study aims to study and analyse - in the theoretical plan basis aspects of social enterprises, and on that to draw and systematize their perspectives for development.

  9. Theoretical Basis Of The Company Competitiveness Assessment

    Vladimir Nikiforovich Belkin

    2015-03-01

    Full Text Available The article deals with the basic theoretical questions of the company competitiveness assessment. The state of modern economic thought on this issue is shown. The main factors of the company competitiveness are specified. A specific role of staff of an enterprise is revealed: on the one hand, it is a resource, on the other is a subject, resulting in productive movement all factors of competitiveness, i.e. the staff is a critical factor in the company competitiveness. The criterion of company competitiveness is proposed, on its basis, the concept of “competitive enterprise” is defined. The most well-known approaches for assessing the company competitiveness are analyzed. The author’s method of the company competitiveness assessment based on the dynamics of the integral index of competitiveness is provided. For those cases, when it is impossible to determine the proportion of products on the market, it is proposed to evaluate the company competitiveness on the profitability of its production. The article shows the experience in calculating of the company competitiveness on the proposed author’s methods.

  10. Medical basis for radiation accident preparedness

    Huebner, K.F.; Fry, S.A.

    1980-01-01

    The International Conference on The Medical Basis for Radiation Accident Preparedness was organized by the staff of the Radiation Emergency Assistance Center/Training Site (REAC/TS) of the Medical and Health Sciences Division of Oak Ridge Associated Universities (ORAU). The philosophical importance of relating, through investigation and education, the intellectual resources of higher education to the important social problems associated with energy, health, and the environment was the foundation of the meeting. The symposium, held under the auspices of the US Department of Energy, was the ninth since 1960 of a series of international conferences addressing the various aspects of radiation accidents. The approach of this most recent conference differed somewhat from that of those preceding it, in that it sought an international review of the gamut of the medical aspects of radiation injury, not only for the experts in the field, but also for other physicians and scientists who, in view of current events, have had the need to know thrust upon them. Individual entries were made for the separate papers

  11. Geometrical basis for the Standard Model

    Potter, Franklin

    1994-02-01

    The robust character of the Standard Model is confirmed. Examination of its geometrical basis in three equivalent internal symmetry spaces-the unitary plane C 2, the quaternion space Q, and the real space R 4—as well as the real space R 3 uncovers mathematical properties that predict the physical properties of leptons and quarks. The finite rotational subgroups of the gauge group SU(2) L × U(1) Y generate exactly three lepton families and four quark families and reveal how quarks and leptons are related. Among the physical properties explained are the mass ratios of the six leptons and eight quarks, the origin of the left-handed preference by the weak interaction, the geometrical source of color symmetry, and the zero neutrino masses. The ( u, d) and ( c, s) quark families team together to satisfy the triangle anomaly cancellation with the electron family, while the other families pair one-to-one for cancellation. The spontaneously broken symmetry is discrete and needs no Higgs mechanism. Predictions include all massless neutrinos, the top quark at 160 GeV/ c 2, the b' quark at 80 GeV/ c 2, and the t' quark at 2600 GeV/ c 2.

  12. Accelerator production of tritium authorization basis strategy

    Miller, L.A.; Edwards, J.; Rose, S.

    1996-01-01

    The Accelerator Production of Tritium (APT) project has proposed a strategy to develop the APT authorization basis and safety case based on DOE orders and fundamental requirements for safe operation. The strategy is viable regardless of whether the APT is regulated by DOE or by an external regulatory body. Currently the operation of Department of Energy (DOE) facilities is authorized by DOE and regulated by DOE orders and regulations while meeting the environmental protection requirements of the Environmental Protection Agency (EPA) and the states. In the spring of 1994, Congress proposed legislation and held hearings related to requiring all DOE operations to be subject to external regulation. On January 25, 1995, DOE, with the support of the White House Council on Environmental Quality, created the Advisory Committee on External Regulation of Department of Energy Nuclear Safety. This committee divided its recommendations into three areas: (1) facility safety, (2) worker safety, and (3) environmental protection. In the area of facility safety the committee recommended external regulation of DOE nuclear facilities by either the Nuclear Regulatory Commission (NRC) or a restructured Defense Nuclear Facilities Safety Board (DNFSB). In the area of worker safety, the committee recommended that the Occupational Safety and Health Administration (OSHA) regulate DOE nuclear facilities. In the environmental protection area, the committee did not recommend a change in the regulation by the EPA and the states of DOE nuclear facilities. If these recommendations are accepted, all DOE nuclear facilities will be impacted to some extent

  13. Neuronal basis of amblyopia: A review

    Grigg John

    1996-01-01

    Full Text Available Amblyopia is an acquired defect in vision due to an abnormal visual experience during a sensitive period of visual development. The neuronal basis of amblyopia is the study of the effects of "abnormal" environmental influences on the genetically programmed development of the visual processing system. Visual pathway development commences with ganglion cells forming the optic nerve. The process that guides these neurones initially to the lateral geniculate nucleus (LGN and then onto the visual cortex is genetically programmed. Initially this process is influenced by spontaneously generated impulses and neurotrophic factors. Following birth, visual stimuli modify and refine the genetically programmed process. Exposure to the visual environment includes the risk of abnormal inputs. Abnormal stimuli disrupt the formation of patterned inputs allowing alteration of visual cortical wiring with reduction in ocular dominance columns driven by the abnormal eye. Correction of the abnormal visual input and penalisation of the "normal" input is the mainstay of therapy for amblyopia. Further understanding of the mechanisms involved in the development of a normal visual processing system will allow trialing therapies for amblyopia not responding to occlusion therapy. Levodopa is one agent providing insights into recovery of visual function for short periods in apparently mature visual systems.

  14. Whole-coal versus ash basis in coal geochemistry: a mathematical approach to consistent interpretations

    Geboy, Nicholas J.; Engle, Mark A.; Hower, James C.

    2013-01-01

    Several standard methods require coal to be ashed prior to geochemical analysis. Researchers, however, are commonly interested in the compositional nature of the whole-coal, not its ash. Coal geochemical data for any given sample can, therefore, be reported in the ash basis on which it is analyzed or the whole-coal basis to which the ash basis data are back calculated. Basic univariate (mean, variance, distribution, etc.) and bivariate (correlation coefficients, etc.) measures of the same suite of samples can be very different depending which reporting basis the researcher uses. These differences are not real, but an artifact resulting from the compositional nature of most geochemical data. The technical term for this artifact is subcompositional incoherence. Since compositional data are forced to a constant sum, such as 100% or 1,000,000 ppm, they possess curvilinear properties which make the Euclidean principles on which most statistical tests rely inappropriate, leading to erroneous results. Applying the isometric logratio (ilr) transformation to compositional data allows them to be represented in Euclidean space and evaluated using traditional tests without fear of producing mathematically inconsistent results. When applied to coal geochemical data, the issues related to differences between the two reporting bases are resolved as demonstrated in this paper using major oxide and trace metal data from the Pennsylvanian-age Pond Creek coal of eastern Kentucky, USA. Following ilr transformation, univariate statistics, such as mean and variance, still differ between the ash basis and whole-coal basis, but in predictable and calculated manners. Further, the stability between two different components, a bivariate measure, is identical, regardless of the reporting basis. The application of ilr transformations addresses both the erroneous results of Euclidean-based measurements on compositional data as well as the inconsistencies observed on coal geochemical data

  15. Cortical basis of communication: local computation, coordination, attention.

    Alexandre, Frederic

    2009-03-01

    Human communication emerges from cortical processing, known to be implemented on a regular repetitive neuronal substratum. The supposed genericity of cortical processing has elicited a series of modeling works in computational neuroscience that underline the information flows driven by the cortical circuitry. In the minimalist framework underlying the current theories for the embodiment of cognition, such a generic cortical processing is exploited for the coordination of poles of representation, as is reported in this paper for the case of visual attention. Interestingly, this case emphasizes how abstract internal referents are built to conform to memory requirements. This paper proposes that these referents are the basis for communication in humans, which is firstly a coordination and an attentional procedure with regard to their congeners.

  16. The neural basis of attaining conscious awareness of sad mood.

    Smith, Ryan; Braden, B Blair; Chen, Kewei; Ponce, Francisco A; Lane, Richard D; Baxter, Leslie C

    2015-09-01

    The neural processes associated with becoming aware of sad mood are not fully understood. We examined the dynamic process of becoming aware of sad mood and recovery from sad mood. Sixteen healthy subjects underwent fMRI while participating in a sadness induction task designed to allow for variable mood induction times. Individualized regressors linearly modeled the time periods during the attainment of self-reported sad and baseline "neutral" mood states, and the validity of the linearity assumption was further tested using independent component analysis. During sadness induction the dorsomedial and ventrolateral prefrontal cortices, and anterior insula exhibited a linear increase in the blood oxygen level-dependent (BOLD) signal until subjects became aware of a sad mood and then a subsequent linear decrease as subjects transitioned from sadness back to the non-sadness baseline condition. These findings extend understanding of the neural basis of conscious emotional experience.

  17. Genetic basis of triatomine behavior: lessons from available insect genomes

    Jose Manuel Latorre-Estivalis

    2013-01-01

    Full Text Available Triatomines have been important model organisms for behavioural research. Diverse reports about triatomine host search, pheromone communication in the sexual, shelter and alarm contexts, daily cycles of activity, refuge choice and behavioural plasticity have been published in the last two decades. In recent times, a variety of molecular genetics techniques has allowed researchers to investigate elaborate and complex questions about the genetic bases of the physiology of insects. This, together with the current characterisation of the genome sequence of Rhodnius prolixus allows the resurgence of this excellent insect physiology model in the omics era. In the present revision, we suggest that studying the molecular basis of behaviour and sensory ecology in triatomines will promote a deeper understanding of fundamental aspects of insect and, particularly, vector biology. This will allow uncovering unknown features of essential insect physiology questions for a hemimetabolous model organism, promoting more robust comparative studies of insect sensory function and cognition.

  18. Draft Geologic Disposal Requirements Basis for STAD Specification

    Ilgen, Anastasia G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bryan, Charles R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hardin, Ernest [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-03-25

    This document provides the basis for requirements in the current version of Performance Specification for Standardized Transportation, Aging, and Disposal Canister Systems, (FCRD-NFST-2014-0000579) that are driven by storage and geologic disposal considerations. Performance requirements for the Standardized Transportation, Aging, and Disposal (STAD) canister are given in Section 3.1 of that report. Here, the requirements are reviewed and the rationale for each provided. Note that, while FCRD-NFST-2014-0000579 provides performance specifications for other components of the STAD storage system (e.g. storage overpack, transfer and transportation casks, and others), these have no impact on the canister performance during disposal, and are not discussed here.

  19. Climate Change: The Physical Basis and Latest Results

    CERN. Geneva

    2009-01-01

    The 2007 Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) concludes: "Warming in the climate system is unequivocal." Without the contribution of Physics to climate science over many decades, such a statement would not have been possible. Experimental physics enables us to read climate archives such as polar ice cores and so provides the context for the current changes. For example, today the concentration of CO2 in the atmosphere, the second most important greenhouse gas, is 28% higher than any time during the last 800,000 years. Classical fluid mechanics and numerical mathematics are the basis of climate models from which estimates of future climate change are obtained. But major instabilities and surprises in the Earth System are still unknown. These are also to be considered when the climatic consequences of proposals for geo-engineering are estimated. Only Physics will permit us to further improve our understanding in order to provide the foundation for policy decisions facing the...

  20. The genetic basis of music ability

    Tan, Yi Ting; McPherson, Gary E.; Peretz, Isabelle; Berkovic, Samuel F.; Wilson, Sarah J.

    2014-01-01

    Music is an integral part of the cultural heritage of all known human societies, with the capacity for music perception and production present in most people. Researchers generally agree that both genetic and environmental factors contribute to the broader realization of music ability, with the degree of music aptitude varying, not only from individual to individual, but across various components of music ability within the same individual. While environmental factors influencing music development and expertise have been well investigated in the psychological and music literature, the interrogation of possible genetic influences has not progressed at the same rate. Recent advances in genetic research offer fertile ground for exploring the genetic basis of music ability. This paper begins with a brief overview of behavioral and molecular genetic approaches commonly used in human genetic analyses, and then critically reviews the key findings of genetic investigations of the components of music ability. Some promising and converging findings have emerged, with several loci on chromosome 4 implicated in singing and music perception, and certain loci on chromosome 8q implicated in absolute pitch and music perception. The gene AVPR1A on chromosome 12q has also been implicated in music perception, music memory, and music listening, whereas SLC6A4 on chromosome 17q has been associated with music memory and choir participation. Replication of these results in alternate populations and with larger samples is warranted to confirm the findings. Through increased research efforts, a clearer picture of the genetic mechanisms underpinning music ability will hopefully emerge. PMID:25018744

  1. The neural basis of academic achievement motivation.

    Mizuno, Kei; Tanaka, Masaaki; Ishii, Akira; Tanabe, Hiroki C; Onoe, Hirotaka; Sadato, Norihiro; Watanabe, Yasuyoshi

    2008-08-01

    We have used functional magnetic resonance imaging to study the neural correlates of motivation, concentrating on the motivation to learn and gain monetary rewards. We compared the activation in the brain obtained during reported high states of motivation for learning, with the ones observed when the motivation was based on monetary reward. Our results show that motivation to learn correlates with bilateral activity in the putamen, and that the higher the reported motivation, as derived from a questionnaire that each subject filled prior to scanning, the greater the change in the BOLD signals within the putamen. Monetary motivation also activated the putamen bilaterally, though the intensity of activity was not related to the monetary reward. We conclude that the putamen is critical for motivation in different domains and the extent of activity of the putamen may be pivotal to the motivation that drives academic achievement and thus academic successes.

  2. Cognitive Timing: Neuropsychology and Anatomic Basis

    Coslett, H. Branch; Shenton, Jeff; Dyer, Tamarah; Wiener, Martin

    2008-01-01

    We report data from 31 subjects with focal hemisphere lesions (15 left hemisphere) as well as 16 normal controls on a battery of tasks assessing the estimation, production and reproduction of time intervals ranging from 2–12 seconds. Both visual and auditory stimuli were employed for the estimation and production tasks. First, ANOVAs were performed to assess the effect of stimulus modality on estimation and production tasks; a significant effect of stimulus modality was observed for the produ...

  3. The neural circuit basis of learning

    Patrick, Kaifosh William John

    The astounding capacity for learning ranks among the nervous system's most impressive features. This thesis comprises studies employing varied approaches to improve understanding, at the level of neural circuits, of the brain's capacity for learning. The first part of the thesis contains investigations of hippocampal circuitry -- both theoretical work and experimental work in the mouse Mus musculus -- as a model system for declarative memory. To begin, Chapter 2 presents a theory of hippocampal memory storage and retrieval that reflects nonlinear dendritic processing within hippocampal pyramidal neurons. As a prelude to the experimental work that comprises the remainder of this part, Chapter 3 describes an open source software platform that we have developed for analysis of data acquired with in vivo Ca2+ imaging, the main experimental technique used throughout the remainder of this part of the thesis. As a first application of this technique, Chapter 4 characterizes the content of signaling at synapses between GABAergic neurons of the medial septum and interneurons in stratum oriens of hippocampal area CA1. Chapter 5 then combines these techniques with optogenetic, pharmacogenetic, and pharmacological manipulations to uncover inhibitory circuit mechanisms underlying fear learning. The second part of this thesis focuses on the cerebellum-like electrosensory lobe in the weakly electric mormyrid fish Gnathonemus petersii, as a model system for non-declarative memory. In Chapter 6, we study how short-duration EOD motor commands are recoded into a complex temporal basis in the granule cell layer, which can be used to cancel Purkinje-like cell firing to the longer duration and temporally varying EOD-driven sensory responses. In Chapter 7, we consider not only the temporal aspects of the granule cell code, but also the encoding of body position provided from proprioceptive and efference copy sources. Together these studies clarify how the cerebellum-like circuitry of the

  4. Technical Basis - Spent Nuclear Fuels (SNF) Project Radiation and Contamination Trending Program

    ELGIN, J.C.

    2000-01-01

    This report documents the technical basis for the Spent Nuclear Fuel (SNF) Program radiation and contamination trending program. The program consists of standardized radiation and contamination surveys of the KE Basin, radiation surveys of the KW basin, radiation surveys of the Cold Vacuum Drying Facility (CVD), and radiation surveys of the Canister Storage Building (CSB) with the associated tracking. This report also discusses the remainder of radiological areas within the SNFP that do not have standardized trending programs and the basis for not having this program in those areas

  5. Decision basis for a Danish ultimate storage for low and intermediate radioactive wastes

    2008-11-01

    In 2003 the Danish Parliament consented to let the government start the preparation of a basis for decision on a Danish ultimate storage for low and intermediate radioactive wastes. The present report was prepared by a working group and it presents the final proposal for such a decision basis. The report describes the fundamental safety and environmental principles for establishing an ultimate storage, including determining the principles for site selection, storage construction, and safety analysis. In an appendix, the amount, types, and activity level of the Danish radioactive wastes are presented. (ln)

  6. 9 CFR 590.130 - Basis of billing plants.

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Basis of billing plants. 590.130... of Service § 590.130 Basis of billing plants. Overtime and/or holiday services shall be billed to the official plant on the basis of each 15 minutes of overtime and/or holiday service performed by each...

  7. 26 CFR 1.167(g)-1 - Basis for depreciation.

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Basis for depreciation. 1.167(g)-1 Section 1.167... for depreciation. The basis upon which the allowance for depreciation is to be computed with respect... property at that time, is the basis for computing depreciation. [T.D. 6500, 25 FR 11402, Nov. 26, 1960...

  8. 26 CFR 1.1336-1 - Basis of recovered property.

    2010-04-01

    ... benefits by reason of the basis determined under subparagraph (1) of this paragraph, that it would be... recovered it has an unadjusted basis of $100. After $70 depreciation has been allowed on A, an allocation is sought which would give A an unadjusted basis of $60. Since this is less than the depreciation which is...

  9. The physiognomic basis of sexual stereotyping.

    Nakdimen, K A

    1984-04-01

    Although it is routine for mental status reports to comment on appearance and attractiveness, there is no prevailing theory to explain the psychological impact of physical features. Two perceptual processes are proposed: nonverbal quasi-communication (counterfeit body language) and nonverbal quasi-information (spurious information). Applying this perspective to the sexual dimorphism of anatomy, clothing, and makeup, one finds that appearance fosters the belief that men and women have the personality traits that are stereotypically attributed to them, and this seems to be at the heart of physical attractiveness.

  10. EuroFIR eBASIS: application for health claims submissions and evaluations

    Kiely, M.; Black, L.J.; Plumb, J.

    2010-01-01

    Background: The European Food Information Resource (EuroFIR) network has established the eBASIS (Bioactive Substances in Food Information System) online food composition and biological effects database for plant-derived bioactive compounds (phytochemicals). On the basis of submitted evidence......, the European Food Safety Authority (EFSA) expert panel on Dietetic Products, Nutrition and Allergies assesses whether claims made under articles 13.1, 13.5 or 14 of the Regulation (EC) 1924/2006, which governs the use of nutrition and health claims on foods, are scientifically justified. This report evaluates...... the eBASIS biological effects database in the preparation and evaluation of health claims dossiers. Methods: The eBASIS biological effects database is a compilation of expert-evaluated data extracted from the literature, prioritising human intervention studies to investigate health effects...

  11. Readiness to proceed: Characterization planning basis

    Adams, M.R.

    1998-01-01

    This report summarizes characterization requirements, data availability, and data acquisition plans in support of the Phase 1 Waste Feed Readiness to Proceed Mid-Level Logic. It summarizes characterization requirements for the following program planning documents: Waste Feed Readiness Mid-Level Logic and Decomposition (in development); Master blue print (not available); Tank Waste Remediation System (TWRS) Operations and Utilization Plan and Privatization Contract; Enabling assumptions (not available); Privatization low-activity waste (LAW) Data Quality Objective (DQO); Privatization high-level waste (HLW) DQO (draft); Problem-specific DQOs (in development); Interface control documents (draft). Section 2.0 defines the primary objectives for this report, Section 3.0 discusses the scope and assumptions, and Section 4.0 identifies general characterization needs and analyte-specific characterization needs or potential needs included in program documents and charts. Section 4.0 also shows the analyses that have been conducted, and the archive samples that are available for additional analyses. Section 5.0 discusses current plans for obtaining additional samples and analyses to meet readiness-to-proceed requirements. Section 6.0 summarizes sampling needs based on preliminary requirements and discusses other potential characterization needs. Many requirements documents are preliminary. In many cases, problem-specific DQOs have not been drafted, and only general assumptions about the document contents could be obtained from the authors. As a result, the readiness-to-proceed characterization requirements provided in this document are evolving and may change

  12. The knowledge status EFFEKT: Efficiency shortage. Basis for further research

    Doorman, Gerard; Grande, Ove S.

    2002-02-01

    This report gives a survey of results from the ''Norges forskningsraad'' ( The Norwegian Research Council) program EFFEKT (1996-2000) and some other relevant projects. The report focuses on areas relevant to the efficiency shortage problems and is made as a part of the foundation for the start of the competence project ''Competence Building - Capacity Shortage''. The challenge is to find adequate solutions that satisfies the demands from market participants, systems operators and market actors. This mainly contains problems of both operational and long term strategic character which primarily touches the following main areas: Peak load coverage, operating security and reserves, network capacity and environmental aspects. The results are reported under these headings from several relevant projects. The major challenges in the future will be: 1) Development of mechanisms that bring the right incentives for improved use of the flexibility in the end consumption. 2) Adaptation of the market and organisational conditions in order to improve the consumer flexibility. 3) Further development of the incentive structures for the network owners and systems operators so that the existing transferring capacity is used as well as possible and the macro economic development of the network is encouraged. 4) Profit estimations and financing of larger co-originated connections particularly across the country borders, in deregulated power markets. Particularly the first two challenges are probably a condition for the deregulated power markets as the Nordic one, shall be able to survive in the long run. In an appendix main data studied in the projects as a basis for this report, are referred

  13. Minimization of Basis Risk in Parametric Earthquake Cat Bonds

    Franco, G.

    2009-12-01

    A catastrophe -cat- bond is an instrument used by insurance and reinsurance companies, by governments or by groups of nations to cede catastrophic risk to the financial markets, which are capable of supplying cover for highly destructive events, surpassing the typical capacity of traditional reinsurance contracts. Parametric cat bonds, a specific type of cat bonds, use trigger mechanisms or indices that depend on physical event parameters published by respected third parties in order to determine whether a part or the entire bond principal is to be paid for a certain event. First generation cat bonds, or cat-in-a-box bonds, display a trigger mechanism that consists of a set of geographic zones in which certain conditions need to be met by an earthquake’s magnitude and depth in order to trigger payment of the bond principal. Second generation cat bonds use an index formulation that typically consists of a sum of products of a set of weights by a polynomial function of the ground motion variables reported by a geographically distributed seismic network. These instruments are especially appealing to developing countries with incipient insurance industries wishing to cede catastrophic losses to the financial markets because the payment trigger mechanism is transparent and does not involve the parties ceding or accepting the risk, significantly reducing moral hazard. In order to be successful in the market, however, parametric cat bonds have typically been required to specify relatively simple trigger conditions. The consequence of such simplifications is the increase of basis risk. This risk represents the possibility that the trigger mechanism fails to accurately capture the actual losses of a catastrophic event, namely that it does not trigger for a highly destructive event or vice versa, that a payment of the bond principal is caused by an event that produced insignificant losses. The first case disfavors the sponsor who was seeking cover for its losses while the

  14. Analysis of basis at Eastern hubs and the impact of gas from Sable Island

    Mortensen, P.; Schlesinger, B.; Ratra, A.

    2000-01-01

    The major changes that are happening in natural gas markets in the northeast region of North America can be attributed to the introduction of Sable Island as a new source of gas supply, new domestic industrial markets for gas in Atlantic Canada and Northern New England, and major growth in gas-fired electric power generation. This report presented a long term outlook for new Canadian gas supplies to the northeastern North American market with particular reference to prices and basis relationships that will develop between major existing and potential market centres in the area. The development of pipeline transmission and merchant power plant construction in the region was also reviewed. Four potential scenarios were examined for the period to 2010 via a model-based approach. Emerging basis trends under various market conditions were projected. The key observations from the analysis are that the basis between Northeast city gates and the major producing areas will probably increase greatly by 2010. The rise in basis is mostly due to growth in gas demand while changes in gas supply will have only a minor impact on basis. It was also suggested that reference levels of gas production from Sable Island will not alter prices in a significant manner, but higher levels of gas production from Sable Island will benefit Sable producers and Northeast consumers. Basis impacts are moderated when enough pipeline capacity exists to enable toll discounting. The report also stated that there is little risk to the basis impact when gas demand is greater than forecasted. Fluctuations will occur around the general basis trend. 18 refs., 26 tabs., 39 figs

  15. A convenient basis for the Izergin-Korepin model

    Qiao, Yi; Zhang, Xin; Hao, Kun; Cao, Junpeng; Li, Guang-Liang; Yang, Wen-Li; Shi, Kangjie

    2018-05-01

    We propose a convenient orthogonal basis of the Hilbert space for the quantum spin chain associated with the A2(2) algebra (or the Izergin-Korepin model). It is shown that compared with the original basis the monodromy-matrix elements acting on this basis take relatively simple forms, which is quite similar as that for the quantum spin chain associated with An algebra in the so-called F-basis. As an application of our general results, we present the explicit recursive expressions of the Bethe states in this basis for the Izergin-Korepin model.

  16. Toward a physical basis of attention and self-regulation

    Posner, Michael I.; Rothbart, Mary K.

    2009-06-01

    The concept of self-regulation is central to the understanding of human development. Self-regulation allows effective socialization and predicts both psychological pathologies and levels of achievement in schools. What has been missing are neural mechanisms to provide understanding of the cellular and molecular basis for self-regulation. We show that self-regulation can be measured during childhood by parental reports and by self-reports of adolescents and adults. These reports are summarized by a higher order factor called effortful control, which reflects perceptions about the ability of a given person to regulate their behavior in accord with cultural norms. Throughout childhood effortful control is related to children's performance in computerized conflict related tasks. Conflict tasks have been shown in neuroimaging studies to activate specific brain networks of executive attention. Several brain areas work together at rest and during cognitive tasks to regulate competing brain activity and thus control resulting behavior. The cellular structure of the anterior cingulate and insula contain cells, unique to humans and higher primates that provide strong links to remote brain areas. During conflict tasks, anterior cingulate activity is correlated with activity in remote sensory and emotional systems, depending upon the information selected for the task. During adolescence the structure and activity of the anterior cingulate has been found to be correlated with self-reports of effortful control. Studies have provided a perspective on how genes and environment act to shape the executive attention network, providing a physical basis for self-regulation. The anterior cingulate is regulated by dopamine. Genes that influence dopamine levels in the CNS have been shown to influence the efficiency of self-regulation. For example, alleles of the COMT gene that influence the efficiency of dopamine transmission are related to the ability to resolve conflict. Humans with

  17. Design basis for the NRC Operations Center

    Lindell, M.K.; Wise, J.A.; Griffin, B.N.; Desrosiers, A.E.; Meitzler, W.D.

    1983-05-01

    This report documents the development of a design for a new NRC Operations Center (NRCOC). The project was conducted in two phases: organizational analysis and facility design. In order to control the amount of traffic, congestion and noise within the facility, it is recommended that information flow in the new NRCOC be accomplished by means of an electronic Status Information Management System. Functional requirements and a conceptual design for this system are described. An idealized architectural design and a detailed design program are presented that provide the appropriate amount of space for operations, equipment and circulation within team areas. The overall layout provides controlled access to the facility and, through the use of a zoning concept, provides each team within the NRCOC the appropriate balance of ready access and privacy determined from the organizational analyses conducted during the initial phase of the project.

  18. Physiochemical basis of human degenerative disease.

    Zeliger, Harold I; Lipinski, Boguslaw

    2015-03-01

    The onset of human degenerative diseases in humans, including type 2 diabetes, cardiovascular disease, neurological disorders, neurodevelopmental disease and neurodegenerative disease has been shown to be related to exposures to persistent organic pollutants, including polychlorinated biphenyls, chlorinated pesticides, polybrominated diphenyl ethers and others, as well as to polynuclear aromatic hydrocarbons, phthalates, bisphenol-A and other aromatic lipophilic species. The onset of these diseases has also been related to exposures to transition metal ions. A physiochemical mechanism for the onset of degenerative environmental disease dependent upon exposure to a combination of lipophilic aromatic hydrocarbons and transition metal ions is proposed here. The findings reported here also, for the first time, explain why aromatic hydrocarbons exhibit greater toxicity than aliphatic hydrocarbons of equal carbon numbers.

  19. Structural basis for phosphatidylinositol-phosphate biosynthesis

    Clarke, Oliver B.; Tomasek, David; Jorge, Carla D.; Dufrisne, Meagan Belcher; Kim, Minah; Banerjee, Surajit; Rajashankar, Kanagalaghatta R.; Shapiro, Lawrence; Hendrickson, Wayne A.; Santos, Helena; Mancia, Filippo

    2015-10-01

    Phosphatidylinositol is critical for intracellular signalling and anchoring of carbohydrates and proteins to outer cellular membranes. The defining step in phosphatidylinositol biosynthesis is catalysed by CDP-alcohol phosphotransferases, transmembrane enzymes that use CDP-diacylglycerol as donor substrate for this reaction, and either inositol in eukaryotes or inositol phosphate in prokaryotes as the acceptor alcohol. Here we report the structures of a related enzyme, the phosphatidylinositol-phosphate synthase from Renibacterium salmoninarum, with and without bound CDP-diacylglycerol to 3.6 and 2.5 Å resolution, respectively. These structures reveal the location of the acceptor site, and the molecular determinants of substrate specificity and catalysis. Functional characterization of the 40%-identical ortholog from Mycobacterium tuberculosis, a potential target for the development of novel anti-tuberculosis drugs, supports the proposed mechanism of substrate binding and catalysis. This work therefore provides a structural and functional framework to understand the mechanism of phosphatidylinositol-phosphate biosynthesis.

  20. Physiochemical basis of human degenerative disease

    Zeliger Harold I.

    2015-03-01

    Full Text Available The onset of human degenerative diseases in humans, including type 2 diabetes, cardiovascular disease, neurological disorders, neurodevelopmental disease and neurodegenerative disease has been shown to be related to exposures to persistent organic pollutants, including polychlorinated biphenyls, chlorinated pesticides, polybrominated diphenyl ethers and others, as well as to polynuclear aromatic hydrocarbons, phthalates, bisphenol-A and other aromatic lipophilic species. The onset of these diseases has also been related to exposures to transition metal ions. A physiochemical mechanism for the onset of degenerative environmental disease dependent upon exposure to a combination of lipophilic aromatic hydrocarbons and transition metal ions is proposed here. The findings reported here also, for the first time, explain why aromatic hydrocarbons exhibit greater toxicity than aliphatic hydrocarbons of equal carbon numbers.

  1. Design basis for the NRC Operations Center

    Lindell, M.K.; Wise, J.A.; Griffin, B.N.; Desrosiers, A.E.; Meitzler, W.D.

    1983-05-01

    This report documents the development of a design for a new NRC Operations Center (NRCOC). The project was conducted in two phases: organizational analysis and facility design. In order to control the amount of traffic, congestion and noise within the facility, it is recommended that information flow in the new NRCOC be accomplished by means of an electronic Status Information Management System. Functional requirements and a conceptual design for this system are described. An idealized architectural design and a detailed design program are presented that provide the appropriate amount of space for operations, equipment and circulation within team areas. The overall layout provides controlled access to the facility and, through the use of a zoning concept, provides each team within the NRCOC the appropriate balance of ready access and privacy determined from the organizational analyses conducted during the initial phase of the project

  2. Mixed waste treatment model: Basis and analysis

    Palmer, B.A.

    1995-09-01

    The Department of Energy's Programmatic Environmental Impact Statement (PEIS) required treatment system capacities for risk and cost calculation. Los Alamos was tasked with providing these capacities to the PEIS team. This involved understanding the Department of Energy (DOE) Complex waste, making the necessary changes to correct for problems, categorizing the waste for treatment, and determining the treatment system requirements. The treatment system requirements depended on the incoming waste, which varied for each PEIS case. The treatment system requirements also depended on the type of treatment that was desired. Because different groups contributing to the PEIS needed specific types of results, we provided the treatment system requirements in a variety of forms. In total, some 40 data files were created for the TRU cases, and for the MLLW case, there were 105 separate data files. Each data file represents one treatment case consisting of the selected waste from various sites, a selected treatment system, and the reporting requirements for such a case. The treatment system requirements in their most basic form are the treatment process rates for unit operations in the desired treatment system, based on a 10-year working life and 20-year accumulation of the waste. These results were reported in cubic meters and for the MLLW case, in kilograms as well. The treatment system model consisted of unit operations that are linked together. Each unit operation's function depended on the input waste streams, waste matrix, and contaminants. Each unit operation outputs one or more waste streams whose matrix, contaminants, and volume/mass may have changed as a result of the treatment. These output streams are then routed to the appropriate unit operation for additional treatment until the output waste stream meets the treatment requirements for disposal. The total waste for each unit operation was calculated as well as the waste for each matrix treated by the unit

  3. Psychopathy: clinical features, developmental basis and therapeutic challenges.

    Thompson, D F; Ramos, C L; Willett, J K

    2014-10-01

    Psychopathy is a personality disorder characterized by deficits in personality and behaviour. Personality deficits are marked by interpersonal and affective facets, including pathological lying, grandiose sense of self-worth, lack of remorse and callousness. Behavioural deficits are defined by lifestyle and antisocial deficits, including impulsivity, parasitic lifestyle and poor behavioural controls. The objective of this review is to provide clinicians with (i) an appreciation of the clinical features of psychopathy, (ii) an understanding of the structural and functional derangements and the genetic and environmental factors which serve as the basis for the development of psychopathy and (iii) a summary of published reports of pharmacological approaches to the management of this disorder. A literature search of MEDLINE/PubMed (1966-present) was conducted using the MeSH search terms psychopathy and antisocial personality disorder alone and in combination with the subheading drug therapy. Additional databases included Web of Science (1945-present) and International Pharmaceutical Abstracts (1970-present) using the text words psychopath and antisocial personality were searched. A search of Amazon books using the search terms psychopathy and sociopathy was also performed. Bibliographies of relevant articles were searched for additional citations. All data sources in English were considered for inclusion. For background information, broad subject headings were searched for review articles first. Human and animal drug therapy articles were evaluated giving preference to those papers using a controlled trial methodology. Psychopathy is a personality disorder characterized by a lack of conscience, pathologic lying, manipulative behaviour and often superficial charm. The incidence of psychopathy in the general population is generally considered to be 0·6-4% with a higher proportion of males to females. Brain imaging studies of psychopaths suggest a smaller and less active

  4. Optimized Basis Sets for the Environment in the Domain-Specific Basis Set Approach of the Incremental Scheme.

    Anacker, Tony; Hill, J Grant; Friedrich, Joachim

    2016-04-21

    Minimal basis sets, denoted DSBSenv, based on the segmented basis sets of Ahlrichs and co-workers have been developed for use as environmental basis sets for the domain-specific basis set (DSBS) incremental scheme with the aim of decreasing the CPU requirements of the incremental scheme. The use of these minimal basis sets within explicitly correlated (F12) methods has been enabled by the optimization of matching auxiliary basis sets for use in density fitting of two-electron integrals and resolution of the identity. The accuracy of these auxiliary sets has been validated by calculations on a test set containing small- to medium-sized molecules. The errors due to density fitting are about 2-4 orders of magnitude smaller than the basis set incompleteness error of the DSBSenv orbital basis sets. Additional reductions in computational cost have been tested with the reduced DSBSenv basis sets, in which the highest angular momentum functions of the DSBSenv auxiliary basis sets have been removed. The optimized and reduced basis sets are used in the framework of the domain-specific basis set of the incremental scheme to decrease the computation time without significant loss of accuracy. The computation times and accuracy of the previously used environmental basis and that optimized in this work have been validated with a test set of medium- to large-sized systems. The optimized and reduced DSBSenv basis sets decrease the CPU time by about 15.4% and 19.4% compared with the old environmental basis and retain the accuracy in the absolute energy with standard deviations of 0.99 and 1.06 kJ/mol, respectively.

  5. Strengthening the scientific basis of radiological protection

    Lazo, Edward

    2016-01-01

    The overarching objective of the radiological protection system is to contribute to an appropriate level of protection against the harmful effects of radiation exposure, without unjustifiably limiting the desired results from the human activity causing exposure. Such a balance is achieved by understanding as best as possible the scientific characteristics of radiation exposure and the related health effects, and by taking this knowledge into consideration when judging which protection decisions will ensure the best balance between social and economic aspects and risks. In general, the existing radiological protection system, on which national regulations are built in virtually every country in the world, works well and does not underestimate protection needs for either individuals or exposed populations as a whole. The latest International Commission on Radiological Protection (ICRP) recommendations, which define this protection system, were formed after a long and open dialogue with the public, where expert views were actively collected and discussed at national, regional and international levels. Although the radiological protection system is very effective, and there is no current need for a prompt revision, it is important nonetheless to keep a watchful eye on the latest scientific results, and to work to ensure that the entire radiological protection community is kept up to date on evolving and emerging scientific issues. In this way, potential or actual scientific changes can be appropriately identified and in turn can stimulate reflection on changes that might be needed in the protection system, in policy, in regulation and in practice. Such reflection should benefit from the input of other scientific disciplines and interested stakeholders. To contribute to this process, the NEA Committee on Radiological Protection and Public Health (CRPPH) has periodically reviewed and released reports on the state of the art in radiological protection science (see NEA

  6. Basis set convergence on static electric dipole polarizability calculations of alkali-metal clusters

    Souza, Fabio A. L. de; Jorge, Francisco E.

    2013-01-01

    A hierarchical sequence of all-electron segmented contracted basis sets of double, triple and quadruple zeta valence qualities plus polarization functions augmented with diffuse functions for the atoms from H to Ar was constructed. A systematic study of basis sets required to obtain reliable and accurate values of static dipole polarizabilities of lithium and sodium clusters (n = 2, 4, 6 and 8) at their optimized equilibrium geometries is reported. Three methods are examined: Hartree-Fock (HF), second-order Moeller-Plesset perturbation theory (MP2), and density functional theory (DFT). By direct calculations or by fitting the directly calculated values through one extrapolation scheme, estimates of the HF, MP2 and DFT complete basis set limits were obtained. Comparison with experimental and theoretical data reported previously in the literature is done (author)

  7. Basis set convergence on static electric dipole polarizability calculations of alkali-metal clusters

    Souza, Fabio A. L. de; Jorge, Francisco E., E-mail: jorge@cce.ufes.br [Departamento de Fisica, Universidade Federal do Espirito Santo, 29060-900 Vitoria-ES (Brazil)

    2013-07-15

    A hierarchical sequence of all-electron segmented contracted basis sets of double, triple and quadruple zeta valence qualities plus polarization functions augmented with diffuse functions for the atoms from H to Ar was constructed. A systematic study of basis sets required to obtain reliable and accurate values of static dipole polarizabilities of lithium and sodium clusters (n = 2, 4, 6 and 8) at their optimized equilibrium geometries is reported. Three methods are examined: Hartree-Fock (HF), second-order Moeller-Plesset perturbation theory (MP2), and density functional theory (DFT). By direct calculations or by fitting the directly calculated values through one extrapolation scheme, estimates of the HF, MP2 and DFT complete basis set limits were obtained. Comparison with experimental and theoretical data reported previously in the literature is done (author)

  8. Genetic basis of calcifying cystic odontogenic tumors.

    Akane Yukimori

    Full Text Available Calcifying cystic odontogenic tumors (CCOTs are benign cystic tumors that form abnormally keratinized ghost cells. Mutations in CTNNB1, which encodes beta-catenin, have been implicated in the development of these tumors, but a causal relationship has not been definitively established. Thus, mutational hot spots in 50 cancer genes were examined by targeted next-generation sequencing in 11 samples of CCOT. Mutations in CTNNB1, but not in other genes, were observed in 10 of 11 cases. These mutations constitutively activate beta-catenin signaling by abolishing the phosphorylation sites Asp32, Ser33, or Ser37, and are similar to those reported in pilomatrixoma and adamantinomatous craniopharyngioma. In contrast, BRAF or NRAS mutations were observed in 12 and two control samples of ameloblastoma, respectively. In HEK293 cells, overexpression of mutated CTNNB1 also upregulated hair keratin, a marker of ghost cells. Furthermore, ghost cells were present in two cases of ameloblastoma with BRAF and CTNNB1 mutations, indicating that ghost cells form due to mutations in CTNNB1. The data suggest that mutations in CTNNB1 are the major driver mutations of CCOT, and that CCOT is the genetic analog of pilomatrixoma and adamantinomatous craniopharyngioma in odontogenic tissue.

  9. Cognitive timing: neuropsychology and anatomic basis.

    Coslett, H Branch; Shenton, Jeff; Dyer, Tamarah; Wiener, Martin

    2009-02-13

    We report data from 31 subjects with focal hemisphere lesions (15 left hemisphere) as well as 16 normal controls on a battery of tasks assessing the estimation, production and reproduction of time intervals ranging from 2-12 s. Both visual and auditory stimuli were employed for the estimation and production tasks. First, ANOVAs were performed to assess the effect of stimulus modality on estimation and production tasks; a significant effect of stimulus modality was observed for the production but not the estimation task. Second, accuracy was significantly different for the 2 s interval as compared to longer intervals. Subsequent analyses of the data from 4-12 s stimuli demonstrated that patients with brain lesions were more variable than controls on the estimation and reproduction tasks. Additionally, patients with brain lesions but not controls exhibited significant differences in performance on the different tasks; patients with brain lesions under-produced but over-estimated time intervals of 4-12 s but performed relatively well on the reproduction task, a pattern of performance consistent with a "fast clock". There was a significant correlation between impaired performance and lesions of the parietal lobe but there was no effect of laterality of lesion or correlation between lateral frontal lobe lesions and impairment on any task.

  10. The Genetic Basis of Graves' Disease

    Płoski, Rafał; Szymański, Konrad; Bednarczuk, Tomasz

    2011-01-01

    The presented comprehensive review of current knowledge about genetic factors predisposing to Graves’ disease (GD) put emphasis on functional significance of observed associations. In particular, we discuss recent efforts aimed at refining diseases associations found within the HLA complex and implicating HLA class I as well as HLA-DPB1 loci. We summarize data regarding non-HLA genes such as PTPN22, CTLA4, CD40, TSHR and TG which have been extensively studied in respect to their role in GD. We review recent findings implicating variants of FCRL3 (gene for FC receptor-like-3 protein), SCGB3A2 (gene for secretory uteroglobin-related protein 1- UGRP1) as well as other unverified possible candidate genes for GD selected through their documented association with type 1 diabetes mellitus: Tenr–IL2–IL21, CAPSL (encoding calcyphosine-like protein), IFIH1(gene for interferon-induced helicase C domain 1), AFF3, CD226 and PTPN2. We also review reports on association of skewed X chromosome inactivation and fetal microchimerism with GD. Finally we discuss issues of genotype-phenotype correlations in GD. PMID:22654555

  11. Structural Basis for Differential Neutralization of Ebolaviruses

    John M. Dye

    2012-04-01

    Full Text Available There are five antigenically distinct ebolaviruses that cause hemorrhagic fever in humans or non-human primates (Ebola virus, Sudan virus, Reston virus, Taï Forest virus, and Bundibugyo virus. The small handful of antibodies known to neutralize the ebolaviruses bind to the surface glycoprotein termed GP1,2. Curiously, some antibodies against them are known to neutralize in vitro but not protect in vivo, whereas other antibodies are known to protect animal models in vivo, but not neutralize in vitro. A detailed understanding of what constitutes a neutralizing and/or protective antibody response is critical for development of novel therapeutic strategies. Here, we show that paradoxically, a lower affinity antibody with restricted access to its epitope confers better neutralization than a higher affinity antibody against a similar epitope, suggesting that either subtle differences in epitope, or different characteristics of the GP1,2 molecules themselves, confer differential neutralization susceptibility. Here, we also report the crystal structure of trimeric, prefusion GP1,2 from the original 1976 Boniface variant of Sudan virus complexed with 16F6, the first antibody known to neutralize Sudan virus, and compare the structure to that of Sudan virus, variant Gulu. We discuss new structural details of the GP1-GP2 clamp, thermal motion of various regions in GP1,2 across the two viruses visualized, details of differential interaction of the crystallized neutralizing antibodies, and their relevance for virus neutralization.

  12. Biological basis of total body irradiation

    Dubray, B.; Helfre, S.; Dendale, R.; Cosset, J.M.; Giraud, P.

    1999-01-01

    A comprehensive understanding of the radiobiological bases of total body irradiation (TBI) is made difficult by the large number of normal and malignant tissues that must be taken into account. In addition, tissue responses to irradiation are also sensitive to associated treatments, type of graft and a number of patient characteristics. Experimental studies have yielded a large body of data, the clinical relevance of which still requires definite validation through randomized trials. Fractionated TBI schemes are able to reduce late normal tissue toxicity, but the ultimate consequences of the fractional dose reduction do not appear to be equivocal. Thus, leukemia and lymphoma cells are probably more radio-biologically heterogeneous than previously thought, with several cell lines displaying relatively high radioresistance and repair capability patterns. The most primitive host-type hematopoietic stem cells are likely to be at least partly protected by TBI fractionation and may hamper late engraftment. Similarly, but with possibly conflicting consequences on the probability of engraftment, the persistence of a functional marrow stroma may also be fractionation-sensitive, while higher rejection rates have been reported after T-depletion grafts and fractionated TBI. in clinical practice (as for performance of relevant clinical trials), the influence of these results are rather limited by the heavy logistic constraints created by a sophisticated and time-consuming procedure. Lastly, clinicians are now facing an increasing incidence of second cancers, at least partly induced by irradiation, which jeopardize the long-term prospects of otherwise cured patients. (authors)

  13. Structural Basis of Mitochondrial Transcription Initiation.

    Hillen, Hauke S; Morozov, Yaroslav I; Sarfallah, Azadeh; Temiakov, Dmitry; Cramer, Patrick

    2017-11-16

    Transcription in human mitochondria is driven by a single-subunit, factor-dependent RNA polymerase (mtRNAP). Despite its critical role in both expression and replication of the mitochondrial genome, transcription initiation by mtRNAP remains poorly understood. Here, we report crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mtRNAP to achieve promoter-dependent initiation. TFAM tethers the N-terminal region of mtRNAP to recruit the polymerase to the promoter whereas TFB2M induces structural changes in mtRNAP to enable promoter opening and trapping of the DNA non-template strand. Structural comparisons demonstrate that the initiation mechanism in mitochondria is distinct from that in the well-studied nuclear, bacterial, or bacteriophage transcription systems but that similarities are found on the topological and conceptual level. These results provide a framework for studying the regulation of gene expression and DNA replication in mitochondria. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. FY 2000 survey report on the project for preparation of the international energy utilization rationalization basis. 1st volume. Survey/study for the spread of energy conservation technology; 2000 nendo chosa hokokusho. Kokusai energy shiyo gorika kiban seibi jigyo (Sho energy gijutsu no fukyu no tameno chosa kenkyu to - 1)

    NONE

    2001-03-01

    In China which is the largest energy consumption country in the Asian region and has much room for the spread of energy conservation technology, investigational study was made with the aim of widely spreading energy conservation technology and solving environmental problems. To grasp energy supply/demand in China, environmental problems, industrial structure and social system, it is necessary to have process for establishment of data monitoring method, construction of database and model simulation. Proposal for model simulation was made. Further, to make macro-basis assessment of potentiality of energy conservation and environmental effect by sector in China, following the previous fiscal year, study was made on the electric power industry, where there is big potentiality of heightening energy utilization efficiency but the rationalization is not proceeded with. Moreover, in this fiscal year, energy demand is expected to increase with the growing economy, and the traffic field which has a great effect on the environment was added to the investigational research. (NEDO)

  15. Structural basis for the enhanced activity of cyclic antimicrobial peptides : The case of BPC194

    Mika, Jacek T.; Moiset, Gemma; Cirac, Anna D.; Feliu, Lidia; Bardaji, Eduard; Planas, Marta; Sengupta, Durba; Marrink, Siewert J.; Poolman, Bert

    We report the molecular basis for the differences in activity of cyclic and linear antimicrobial peptides. We iteratively performed atomistic molecular dynamics simulations and biophysical measurements to probe the interaction of a cyclic antimicrobial peptide and its inactive linear analogue with

  16. What the voice reveals : Within- and between-category stereotyping on the basis of voice

    Ko, SJ; Judd, CM; Blair, [No Value; Blair, I.V

    The authors report research that attempts to shift the traditional focus of visual cues to auditory cues as a basis for stereotyping. Moreover, their approach examines whether gender-signaling vocal cues lead not only to between-category but also to within-category gender stereotyping. Study 1

  17. Stringed converters on a basis of Ge1-xSix monocrystals

    Abbasov, Sh.M.; Abbasov, Sh. I.; Baytsar, R.I

    2003-01-01

    Full Text: The representing electromechanical resonator on elastic vibrations of monocrystal strings from semiconductor materials rather simple in manufacturing of stringed tenzoconverter on the basis of Ge-Si monocrystals was described. The examples os such class of converters using in concrete designs of devices for measurement of various physical parameters were reported

  18. Formulation of the fundamental basis for the evaluation of the comparability of different measuring method for the determination of ground air radon concentration. Vol. 1. Final report; Erarbeitung fachlicher Grundlagen zur Beurteilung der Vergleichbarkeit unterschiedlicher Messmethoden zur Bestimmung der Radonbodenluftkonzentration. Bd. 1. Abschlussbericht

    Kemski, J.; Klingel, R.; Siehl, A.; Neznal, M.; Matolin, M.

    2012-03-15

    The final report on report on ground air radon measurements includes the following chapters: Scope of the research program; Concept of the research project; Development of a passive method for ground air measurement; Sampling and measuring methods; Measured areas; Field measurements; results of geophysical investigations: Castle Lede, Messdorfer Field; Lounovice; Procedural method; Results of ground air radon concentration measurements, meteorological and geophysical parameters; Evaluation, discussion and conclusions.

  19. Integral Monitored Retrievable Storage (MRS) Facility conceptual basis for design

    1985-10-01

    The purpose of the Conceptual Basis for Design is to provide a control document that establishes the basis for executing the conceptual design of the Integral Monitored Retrievable Storage (MRS) Facility. This conceptual design shall provide the basis for preparation of a proposal to Congress by the Department of Energy (DOE) for construction of one or more MRS Facilities for storage of spent nuclear fuel, high-level radioactive waste, and transuranic (TRU) waste. 4 figs., 25 tabs

  20. Knowledge basis in safety culture for researchers and practitioners

    Vieira Neto, Antonio S.; Barroso, Antonio C.O.; Goncalves, Adriana

    2009-01-01

    This paper presents the main characteristics of the knowledge basis in safety culture which is being developed at the IPEN-CNEN/SP, one of the Brazilian nuclear institutes of research. The main objective of this basis is to organize the information about safety culture found in the literature and to make it available to researchers and practitioners. The first stage of the development of this basis is already finished being the subject of this work. (author)

  1. Organic Solvent Tropical Report

    COWLEY, W.L.

    2000-01-01

    This report provides the basis for closing the organic solvent safety issue. Sufficient information is presented to conclude that risk posed by an unmitigated organic solvent fire is within risk evaluation guidelines

  2. FY 2000 report on the survey of the project for arrangement of the basis of the international energy utilization rationalization. Survey of diagnosis of energy conservation in main industries of ASEAN countries; 2000 nendo kokusai energy shiyo gorika kiban seibi jigyo chosa hokokusho. ASEAN shokoku shuyo sangyo ni okeru sho energy shindan chosa

    NONE

    2001-03-01

    For the purpose of securing the stable energy supply/demand and contributing to the sustainable economic growth in ASEAN countries, survey of the diagnosis of energy conservation was conducted. In this survey, the diagnosis on energy conservation was made in terms of typical plants/works jointly with ASEAN-side engineers to grasp the actual state of energy consumption of each of the plants and to give advice on energy conservation policies. The countries and companies selected as objects in this fiscal year are a fiber plant in Malaysia (Arab-Malaysian Development Berhad), a paper mill in Indonesia (P.T.Kertas Leces Pulp Paper Mill) and a cement plant in Brunei (Butra Djajanti Cement SDN BHD). Diagnosis was made for each of them on January 15-19, on January 22-26 and on February 5-9, 2001, respectively. Through Workshops No. 1 (November 2000) and No. 2 (December 2000), this diagnosis program was carried out in 2001. On the basis of the results of the diagnosis, presented were the necessary energy conservation policies to be taken. (NEDO)

  3. Cultural influences on neural basis of intergroup empathy.

    Cheon, Bobby K; Im, Dong-Mi; Harada, Tokiko; Kim, Ji-Sook; Mathur, Vani A; Scimeca, Jason M; Parrish, Todd B; Park, Hyun Wook; Chiao, Joan Y

    2011-07-15

    Cultures vary in the extent to which people prefer social hierarchical or egalitarian relations between individuals and groups. Here we examined the effect of cultural variation in preference for social hierarchy on the neural basis of intergroup empathy. Using cross-cultural neuroimaging, we measured neural responses while Korean and American participants observed scenes of racial ingroup and outgroup members in emotional pain. Compared to Caucasian-American participants, Korean participants reported experiencing greater empathy and elicited stronger activity in the left temporo-parietal junction (L-TPJ), a region previously associated with mental state inference, for ingroup compared to outgroup members. Furthermore, preferential reactivity within this region to the pain of ingroup relative to outgroup members was associated with greater preference for social hierarchy and ingroup biases in empathy. Together, these results suggest that cultural variation in preference for social hierarchy leads to cultural variation in ingroup-preferences in empathy, due to increased engagement of brain regions associated with representing and inferring the mental states of others. Copyright © 2011 Elsevier Inc. All rights reserved.

  4. Unravelling the genetic basis of simplex Retinitis Pigmentosa cases

    Bravo-Gil, Nereida; González-del Pozo, María; Martín-Sánchez, Marta; Méndez-Vidal, Cristina; Rodríguez-de la Rúa, Enrique; Borrego, Salud; Antiñolo, Guillermo

    2017-01-01

    Retinitis Pigmentosa (RP) is the most common form of inherited retinal dystrophy (IRD) characterized ultimately by photoreceptors degeneration. Exhibiting great clinical and genetic heterogeneity, RP can be inherited as an autosomal dominant (ad), autosomal recessive (ar) and X-linked (xl) disorder. Although the relative prevalence of each form varies somewhat between populations, a major proportion (41% in Spain) of patients represent simplex cases (sRP) in which the mode of inheritance is unknown. Molecular genetic diagnostic is crucial, but also challenging, for sRP patients because any of the 81 RP genes identified to date may be causative. Herein, we report the use of a customized targeted gene panel consisting of 68 IRD genes for the molecular characterization of 106 sRP cases. The diagnostic rate was 62.26% (66 of 106) with a proportion of clinical refinements of 30.3%, demonstrating the high efficiency of this genomic approach even for clinically ambiguous cases. The high number of patients diagnosed here has allowed us to study in detail the genetic basis of the sRP. The solved sRP cohort is composed of 62.1% of arRP cases, 24.2% of adRP and 13.6% of xlRP, which implies consequences for counselling of patients and families. PMID:28157192

  5. The Pharmacological Basis of Cannabis Therapy for Epilepsy.

    Reddy, Doodipala Samba; Golub, Victoria M

    2016-04-01

    Recently, cannabis has been suggested as a potential alternative therapy for refractory epilepsy, which affects 30% of epilepsy, both adults and children, who do not respond to current medications. There is a large unmet medical need for new antiepileptics that would not interfere with normal function in patients with refractory epilepsy and conditions associated with refractory seizures. The two chief cannabinoids are Δ-9-tetrahyrdrocannabinol, the major psychoactive component of marijuana, and cannabidiol (CBD), the major nonpsychoactive component of marijuana. Claims of clinical efficacy in epilepsy of CBD-predominant cannabis or medical marijuana come mostly from limited studies, surveys, or case reports. However, the mechanisms underlying the antiepileptic efficacy of cannabis remain unclear. This article highlights the pharmacological basis of cannabis therapy, with an emphasis on the endocannabinoid mechanisms underlying the emerging neurotherapeutics of CBD in epilepsy. CBD is anticonvulsant, but it has a low affinity for the cannabinoid receptors CB1 and CB2; therefore the exact mechanism by which it affects seizures remains poorly understood. A rigorous clinical evaluation of pharmaceutical CBD products is needed to establish the safety and efficacy of their use in the treatment of epilepsy. Identification of mechanisms underlying the anticonvulsant efficacy of CBD is also critical for identifying other potential treatment options. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

  6. Report: Fiscal Year 2009 Federal Information Security Management Act Report

    Report #10-P-0030, November 18, 2009. We believe the evidence obtained provides a reasonable basis for our findings and conclusions, and in all material respects meets the FISMA reporting requirements prescribed by OMB.

  7. TreeBASIS Feature Descriptor and Its Hardware Implementation

    Spencer Fowers

    2014-01-01

    Full Text Available This paper presents a novel feature descriptor called TreeBASIS that provides improvements in descriptor size, computation time, matching speed, and accuracy. This new descriptor uses a binary vocabulary tree that is computed using basis dictionary images and a test set of feature region images. To facilitate real-time implementation, a feature region image is binary quantized and the resulting quantized vector is passed into the BASIS vocabulary tree. A Hamming distance is then computed between the feature region image and the effectively descriptive basis dictionary image at a node to determine the branch taken and the path the feature region image takes is saved as a descriptor. The TreeBASIS feature descriptor is an excellent candidate for hardware implementation because of its reduced descriptor size and the fact that descriptors can be created and features matched without the use of floating point operations. The TreeBASIS descriptor is more computationally and space efficient than other descriptors such as BASIS, SIFT, and SURF. Moreover, it can be computed entirely in hardware without the support of a CPU for additional software-based computations. Experimental results and a hardware implementation show that the TreeBASIS descriptor compares well with other descriptors for frame-to-frame homography computation while requiring fewer hardware resources.

  8. 26 CFR 1.1014-3 - Other basis rules.

    2010-04-01

    ... inheritance or transmission taxes shall be deemed to be its fair market value and no alternate valuation date... Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Basis Rules of General Application § 1.1014-3 Other basis rules. (a) Fair market value. For...

  9. 7 CFR 58.132 - Basis for classification.

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Basis for classification. 58.132 Section 58.132 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Milk § 58.132 Basis for classification. The quality classification of raw milk for manufacturing...

  10. 42 CFR 417.470 - Basis and scope.

    2010-10-01

    ...) MEDICARE PROGRAM HEALTH MAINTENANCE ORGANIZATIONS, COMPETITIVE MEDICAL PLANS, AND HEALTH CARE PREPAYMENT PLANS Medicare Contract Requirements § 417.470 Basis and scope. (a) Basis. This subpart implements those... section 1876(c), (g), (h), and (i) of the Act that pertain to the contract between CMS and an HMO or CMP...

  11. Transuranic waste storage and assay facility (TRUSAF) interim safety basis

    Gibson, K.D.

    1995-09-01

    The TRUSAF ISB is based upon current facility configuration and procedures. The purpose of the document is to provide the basis for interim operation or restrictions on interim operations and the authorization basis for the TRUSAF at the Hanford Site. The previous safety analysis document TRUSAF hazards Identification and Evaluation (WHC 1977) is superseded by this document

  12. 26 CFR 1.996-5 - Adjustment to basis.

    2010-04-01

    ... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Adjustment to basis. 1.996-5 Section 1.996-5 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Domestic International Sales Corporations § 1.996-5 Adjustment to basis. (a) Addition to...

  13. Constitutional Basis for the Enforcement of ''Executive'' Policies that ...

    Although "executive" policies remain an important governance tool, there appears to be confusion on the status and possible basis for their judicial enforcement in South Africa. The aim of this article is to critically reflect on the status and possible constitutional basis for the enforceability of "executive" policies that give effect ...

  14. The resonating group method in an harmonic oscillator basis

    Silvestre-Brac, B.; Gignoux, C.; Ayant, Y.

    1987-05-01

    The scattering states for a general many body system is formulated within the resonating group method. The resulting Lippman-Schwinger equation is solved in an harmonic oscillator basis for which a number of advantages are emphasized. The analytical formula giving the free propagator in that basis is fully derived

  15. 42 CFR 438.700 - Basis for imposition of sanctions.

    2010-10-01

    ... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE Sanctions § 438.700 Basis for imposition of... among enrollees on the basis of their health status or need for health care services. This includes termination of enrollment or refusal to reenroll a recipient, except as permitted under the Medicaid program...

  16. Using piecewise sinusoidal basis functions to blanket multiple wire segments

    Lysko, AA

    2009-06-01

    Full Text Available This paper discusses application of the piecewise sinusoidal (PWS) basis function (BF) over a chain of several wire segments, for example as a multiple domain basis function. The usage of PWS BF is compared to results based on the piecewise linear...

  17. 42 CFR 403.200 - Basis and scope.

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and scope. 403.200 Section 403.200 Public... PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental Policies § 403.200 Basis and scope. (a... intent of that section is to enable Medicare beneficiaries to identify Medicare supplemental policies...

  18. 45 CFR 148.306 - Basis and scope.

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Basis and scope. 148.306 Section 148.306 Public... FOR THE INDIVIDUAL HEALTH INSURANCE MARKET Grants to States for Operation of Qualified High Risk Pools § 148.306 Basis and scope. This subpart implements section 2745 of the Public Health Service Act (PHS...

  19. Commentaries on Hilbert's Basis Theorem | Apine | Science World ...

    The famous basis theorem of David Hilbert is an important theorem in commutative algebra. In particular the Hilbert's basis theorem is the most important source of Noetherian rings which are by far the most important class of rings in commutative algebra. In this paper we have used Hilbert's theorem to examine their unique ...

  20. Optimization of the variational basis in the three body problem

    Simenog, I.V.; Pushkash, O.M.; Bestuzheva, A.B.

    1995-01-01

    The procedure of variational oscillator basis optimization is proposed to the calculation the energy spectra of three body systems. The hierarchy of basis functions is derived and energies of ground and excited states for three gravitating particles is obtained with high accuracy. 12 refs

  1. Localized atomic basis set in the projector augmented wave method

    Larsen, Ask Hjorth; Vanin, Marco; Mortensen, Jens Jørgen

    2009-01-01

    We present an implementation of localized atomic-orbital basis sets in the projector augmented wave (PAW) formalism within the density-functional theory. The implementation in the real-space GPAW code provides a complementary basis set to the accurate but computationally more demanding grid...

  2. Experimental investigations for provision of a data basis for optimization of active surge control. Final report; Experimentelle Untersuchungen zur Bereitstellung einer Datenbasis fuer die Optimierung der aktiven Stabilitaetsverbesserung. Teilverbund-Projekt: Aktive Stabilitaetsverbesserung - Analyseverfahren der Arbeitsgemeinschaft AG Turbo II. Abschlussbericht zum Vorhaben 1.1.4

    Seume, J.; Reissner, A.

    2001-07-01

    Presently axial compressors have to run with considerable distance to operation points of high load although usually the best efficiencies can be obtained there. In those areas there is high danger of surge which brings high damaging potential to the compressor. The prediction time to surge presently is very short (<<1s) and depends on the load and rotor rotation of the compressor. The goal of this project is the production of a data basis to investigate stall inception (which is the precursor of surge) and to develop and test better precursory warning algorithms. An extensive set of data as well in stable as in unstable operating points in different load areas was developed which now is ready for use in research, verification and for comparison of forewarning systems. (orig.) [German] Zur Zeit ist es notwendig, Axialverdichter mit deutlichem Abstand von den hoch belasteten Betriebspunkten zu betreiben, obwohl haeufig dort die besten Wirkungsgrade zu erzielen waeren. In diesen Bereichen kann es leicht zu sog. Pumpen kommen, wodurch der Verdichter einem extremen Schaedigungspotential ausgesetzt ist. Die Vorwarnzeiten fuer das Pumpen sind bisher noch sehr kurz. Sie liegen in einem Bereich von deutlich weniger als einer Sekunde (abhaengig von der Belastung und der Drehzahl des Verdichters). Ziel dieser Untersuchungen ist es, eine Datenbasis zu liefern, anhand derer die Entstehungsmechanismen untersucht und moeglichst fruehzeitige Vorwarnalgorithmen entwickelt bzw. erprobt werden koennen. Es wurde eine umfangreiche Datenbasis sowohl an verschiedenen stabilen als auch instabilen Betriebspunkten in unterschiedlichen Lastbereichen erstellt, die nun zur Entwicklung, zur Verifizierung und zum Vergleich von Fruehwarnsystemen zur Verfuegung steht. (orig.)

  3. The bioenergy village - preconditions and consequences of autonomous heat and power supply on the basis of biomass for agricultrue, ecology and lifestyle in rural regions. Final report phase I; Das Bioenergiedorf - Voraussetzungen und Folgen einer eigenstaendigen Waerme- und Stromversorgung durch Biomasse fuer Landwirtschaft, Oekologie und Lebenskultur im laendlichen Raum. Endbericht Phase I

    Ruppert, H.; Ahl, C.; Girschner, W.; Krumbein, W.; Marggraf, R.; Scheffer, K.; Schmuck, P. (eds.)

    2003-07-01

    With support from the Federal Minister of Consumer Protection, Nutrition and Agriculture through the Fachagentur Nachwachsende Rohstoffe e.V. (Renewable Fuels Agency), a project group of Goettingen University was able to demonstrate how complete conversion to biomass of heat and power supply can be achieved for a whole village with maximum social acceptance, environmental compatibility, and economic and technical efficiency. This and further projects will provide flexible, generally applicable concepts for wider use and are expected to give new impetus to bioenergy and help reduce CO2 emissions. This documentation presents the results of the first project phase, which lasted from October 2000 through November 2002. After describing the criteria for which the model village was selected, the work carried out by the various scientific disciplines cooperating in the project (environmental geoscience, crop research, soil research, agricultural economy, psychology, sociology and political science) is described, and the current project status is outlined. (orig.) [German] Mit Unterstuetzung des Bundesministeriums fuer Verbraucherschutz, Ernaehrung und Landwirtschaft durch die Fachagentur Nachwachsende Rohstoffe e.V. konnte die Projektgruppe der Universitaet damit beginnen, beispielhaft in einem Dorf zu demonstrieren, wie eine komplette Umstellung der Strom- und Waermeversorgung auf den Energietraeger Biomasse sozial, umweltvertraeglich, wirtschaftlich und technisch erfolgen kann. Auf der Basis dieser konkreten Umstellugsarbeiten und Erfahrungen aus anderen aehnlichen Projekten sollen uebertragbare, flexible Konzepte erarbeitet werden, die der Nutzung der Bioenergie einen deutlichen Auftrieb geben und dadurch auch erhebliche Kohlendioxid-Einsparpotentiale erschliessen koennen. In dieser Dokumentation sind die Ergebnisse der ersten Phase des Projektes 'Das Bioenergiedorf' vom Oktober 2000 bis November 2002 niedergelegt. Es wird zunaechst in einem Ueberblick

  4. Analysis and chemometry of heavy metal concentrations in the Saale, Ilm and Unstrut as a basis for assessing the pollutant level and the prospects for success of sanitation measures. Final report; Analyse und chemometrische Bewertung von Schwermetallgehalten der Saale, Ilm und Unstrut als Bestandsaufnahme und zur Abschaetzung der Auswirkungen von Sanierungsmassnahmen. Abschlussbericht

    Einax, J.W.; Truckenbrodt, D.; Kampe, O.

    1997-09-01

    Since the mid-1980`s, heavy metal characterisation was carried out on sediments of selected sections of the river Saale and methodical work was done on the analysis of flowing water at the Friedrich Schiller University at Jena. However, there was no comprehensive and current information about the state of contamination along the whole course of the river before. The most important aim was therefore the first and current stocktaking of this extent of contamination of the water, sediment and suspended matter of the Saale. The basis of these considerations was formed by about 15,000 determined features in water samples and more than 1,000 examinations of suspended matter and 4,600 examinations of sediment. In the characterisation of contamination of flowing watercourses, it was generally usual to evaluate the change of individual features according to geographic or time aspects. The application of methods of multi-variate statistics makes it possible to identify anthropogenic and geogenic sources and to discover latent connections. A comprehensive evaluation of the actual contamination situation is possible in this way. (orig./SR) [Deutsch] Seit Mitte der achtziger Jahre werden an der Friedrich-Schiller-Universitaet Jena Schwermetallcharakterisierungen an Sedimenten ausgewaehlter Flussabschnitte der Saale sowie methodische Arbeiten zur Fliessgewaesseranalytik durchgefuehrt. Umfassende und aktuelle Informationen ueber den Belastungszustand entlang des gesamten Flussablaufes gab es jedoch bisher nicht. Wichtigstes Ziel war deshalb eine in diesem Umfang erstmalige und aktuelle Bestandsaufnahme zur Belastung von Wasser, Sediment und Schwebstoffe der Saale. Die Grundlage dieser Betrachtungen bilden ca. 15.000 bestimmte Merkmale in Wasserproben und mehr als 1.000 Schwebstoff- und 4.600 Sedimentuntersuchungen. Bei der Belastungscharakterisierung von Fliessgewaessern ist es derzeit allgemein ueblich, die Aenderung einzelner Merkmale nach geographischen oder zeitlichen

  5. Demand of authorization to create the 'Flamanville 3' Basis Nuclear Installation. Synthesis report of the technical examination; Demande d'autorisation de creation de l'INB 'Flamanville 3'. Rapport de synthese de l'examen technique

    NONE

    2007-02-15

    The present report has for objective to present to the College of Asn a synthesis of the technical instruction piloted by the services of Asn and realized by their technical supports (I.R.S.N., G.P.R., S.P.N.) during the period 2001-2006. After a reminder of the conditions of the examination of the safety options of the project EPR made between 1993 and 2000, this report explains the progress and the modalities of the instruction realized from 2001 till 2006. It draws up then, besides a notice of the Asn services at request of creation authorization, a synthesis of the technical examination realized according to axes presented on the fig 1. Finally, it presents the main lines of the examination that it would stay to realize if the creation authorization was delivered. (N.C.)

  6. Large-Scale Cubic-Scaling Random Phase Approximation Correlation Energy Calculations Using a Gaussian Basis.

    Wilhelm, Jan; Seewald, Patrick; Del Ben, Mauro; Hutter, Jürg

    2016-12-13

    We present an algorithm for computing the correlation energy in the random phase approximation (RPA) in a Gaussian basis requiring [Formula: see text] operations and [Formula: see text] memory. The method is based on the resolution of the identity (RI) with the overlap metric, a reformulation of RI-RPA in the Gaussian basis, imaginary time, and imaginary frequency integration techniques, and the use of sparse linear algebra. Additional memory reduction without extra computations can be achieved by an iterative scheme that overcomes the memory bottleneck of canonical RPA implementations. We report a massively parallel implementation that is the key for the application to large systems. Finally, cubic-scaling RPA is applied to a thousand water molecules using a correlation-consistent triple-ζ quality basis.

  7. Structural basis for target protein recognition by the protein disulfide reductase thioredoxin

    Maeda, Kenji; Hägglund, Per; Finnie, Christine

    2006-01-01

    Thioredoxin is ubiquitous and regulates various target proteins through disulfide bond reduction. We report the structure of thioredoxin (HvTrxh2 from barley) in a reaction intermediate complex with a protein substrate, barley alpha-amylase/subtilisin inhibitor (BASI). The crystal structure...... of this mixed disulfide shows a conserved hydrophobic motif in thioredoxin interacting with a sequence of residues from BASI through van der Waals contacts and backbone-backbone hydrogen bonds. The observed structural complementarity suggests that the recognition of features around protein disulfides plays...... a major role in the specificity and protein disulfide reductase activity of thioredoxin. This novel insight into the function of thioredoxin constitutes a basis for comprehensive understanding of its biological role. Moreover, comparison with structurally related proteins shows that thioredoxin shares...

  8. FY 2000 survey report on the project for preparation of the international energy utilization rationalization basis. 2nd volume. Survey/study for the spread of energy conservation technology; 2000 nendo chosa hokokusho. Kokusai energy shiyo gorika kiban seibi jigyo (Sho energy gijutsu no fukyu no tameno chosa kenkyu to - 2)

    NONE

    2001-03-01

    In China which is the largest energy consumption country in the Asian region and has much room for the spread of energy conservation technology, investigational study was made with the aim of widely spreading energy conservation technology and solving environmental problems. This report summed up the tackling with environmental problems for making improvement in energy conservation. In the study of the CDM introduction based on the heat supply in Beijing city, conducted were the report on the research on the CDM introduction to coal-fired heat supply facilities and small gas boilers and the consideration of possibility/conditions/method of Japan's transfer of technically advanced space heating technology to China. In the study of 'advanced traffic system - Tsinghua University Green Campus Project,' carried out were the simulative study for grasp of the traffic flow in university, consideration of characteristics of exhaust gas at the time of car running on road and the road pollution mechanism, consideration of the study of electric cars considered of the environment. (NEDO)

  9. Organizing the engineering basis of works during NPP construction

    Gorodinskij, Yu.Kh.; Finberg, L.K.; Shapiro, V.I.

    1988-01-01

    Experience in organization of the system of engineering basis of works during the Khmelnitskij NPP construction, aimed at providing the applicability of the software complex realized with a computer when solving the problems arising before the service of engineering basis of works, is described. Calculational complex for solving the problems on the engineering basis of works includes the SM-2420 processor, immediate access and external storages on MD with capacity not less than 1 and 60 Mbit correspondignly, terminal multiplexer, VTA 2000-15 video terminals, not less than 10 pieces of videotons and not less than two SM-6315 alphanumerical printers

  10. Spent Nuclear Fuel (SNF) Project Safety Basis Implementation Strategy

    TRAWINSKI, B.J.

    2000-01-01

    The objective of the Safety Basis Implementation is to ensure that implementation of activities is accomplished in order to support readiness to move spent fuel from K West Basin. Activities may be performed directly by the Safety Basis Implementation Team or they may be performed by other organizations and tracked by the Team. This strategy will focus on five key elements, (1) Administration of Safety Basis Implementation (general items), (2) Implementing documents, (3) Implementing equipment (including verification of operability), (4) Training, (5) SNF Project Technical Requirements (STRS) database system

  11. Total Positivity of the Cubic Trigonometric Bézier Basis

    Xuli Han

    2014-01-01

    Full Text Available Within the general framework of Quasi Extended Chebyshev space, we prove that the cubic trigonometric Bézier basis with two shape parameters λ and μ given in Han et al. (2009 forms an optimal normalized totally positive basis for λ,μ∈(-2,1]. Moreover, we show that for λ=-2 or μ=-2 the basis is not suited for curve design from the blossom point of view. In order to compute the corresponding cubic trigonometric Bézier curves stably and efficiently, we also develop a new corner cutting algorithm.

  12. Gaussian basis sets for use in correlated molecular calculations. IV. Calculation of static electrical response properties

    Woon, D.E.; Dunning, T.H. Jr.

    1994-01-01

    An accurate description of the electrical properties of atoms and molecules is critical for quantitative predictions of the nonlinear properties of molecules and of long-range atomic and molecular interactions between both neutral and charged species. We report a systematic study of the basis sets required to obtain accurate correlated values for the static dipole (α 1 ), quadrupole (α 2 ), and octopole (α 3 ) polarizabilities and the hyperpolarizability (γ) of the rare gas atoms He, Ne, and Ar. Several methods of correlation treatment were examined, including various orders of Moller--Plesset perturbation theory (MP2, MP3, MP4), coupled-cluster theory with and without perturbative treatment of triple excitations [CCSD, CCSD(T)], and singles and doubles configuration interaction (CISD). All of the basis sets considered here were constructed by adding even-tempered sets of diffuse functions to the correlation consistent basis sets of Dunning and co-workers. With multiply-augmented sets we find that the electrical properties of the rare gas atoms converge smoothly to values that are in excellent agreement with the available experimental data and/or previously computed results. As a further test of the basis sets presented here, the dipole polarizabilities of the F - and Cl - anions and of the HCl and N 2 molecules are also reported

  13. Physical Basis for Interfacial Traction-Separation Models

    Neville R. Moody

    2002-01-01

    Many weapon components contain interfaces between dissimilar materials where cracks can initiate and cause failure. In recent years many researchers in the fracture community have adopted a cohesive zone model for simulating crack propagation (based upon traction-separation relations) Sandia is implementing this model in its ASCI codes. There is, however, one important obstacle to using a cohesive zone modeling approach. At the present time traction-separation relations are chosen in an ad hoc manner. The goal of the present work is to determine a physical basis for Traction-Separation (T-U) relations. This report presents results of a program aimed at determining the dependence of such relations on adhesive and bulk properties. The work focused on epoxy/solid interfaces, although the approach is applicable to a broad range of materials. Asymmetric double cantilevered beam and free surface film nanoindentation fracture toughness tests were used to generate a unique set of data spanning length scales, applied mode mixities, and yield (plastic) zone constraint. The crucial roles of crack tip plastic zone size and interfacial adhesion were defined by varying epoxy layer thickness and using coupling agents or special self-assembled monolayers in preparing the samples. The nature of the yield zone was probed in collaborative experiments run at the Advanced Photon Source. This work provides an understanding of the major phenomena governing polymer/solid interfacial fracture and identifies the essential features that must be incorporated in a T-U based cohesive zone failure model. We believe that models using physically based T-U relations provide a more accurate and widely applicable description of interface cracking than models using ad hoc relations. Furthermore, these T-U relations provide an essential tool for using models to tailor interface properties to meet design needs

  14. The molecular basis of hereditary enamel defects in humans.

    Wright, J T; Carrion, I A; Morris, C

    2015-01-01

    The formation of human enamel is highly regulated at the molecular level and involves thousands of genes. Requisites for development of this highly mineralized tissue include cell differentiation; production of a unique extracellular matrix; processing of the extracellular matrix; altering of cell function during different stages of enamel formation; cell movement and attachment; regulation of ion and protein movement; and regulation of hydration, pH, and other conditions of the microenvironment, to name just a few. Not surprising, there is a plethora of hereditary conditions with an enamel phenotype. The objective of this review was to identify the hereditary conditions listed on Online Mendelian Inheritance in Man (OMIM) that have an associated enamel phenotype and whether a causative gene has been identified. The OMIM database was searched with the terms amelogenesis, enamel, dental, and tooth, and all results were screened by 2 individuals to determine if an enamel phenotype was identified. Gene and gene product function was reviewed on OMIM and from publications identified in PubMed. The search strategy revealed 91 conditions listed in OMIM as having an enamel phenotype, and of those, 71 have a known molecular etiology or linked genetic loci. The purported protein function of those conditions with a known genetic basis included enzymes, regulatory proteins, extracellular matrix proteins, transcription factors, and transmembrane proteins. The most common enamel phenotype was a deficient amount of enamel, or enamel hypoplasia, with hypomineralization defects being reported less frequently. Knowing these molecular defects allows an initial cataloging of molecular pathways that lead to hereditary enamel defects in humans. This knowledge provides insight into the diverse molecular pathways involved in enamel formation and can be useful when searching for the genetic etiology of hereditary conditions that involve enamel. © International & American Associations for

  15. The genetic basis of hair whorl, handedness, and other phenotypes

    Hatfield, J.S.

    2006-01-01

    Evidence is presented that RHO, RHCE, and other RH genes, may be interesting candidates to consider when searching for the genetic basis of hair whorl rotation (i.e., clockwise or counterclockwise), handedness (i.e., right handed, left handed or ambidextrous), speech laterality (i.e., right brained or left brained), speech dyslexia (e.g., stuttering), sexual orientation (i.e., heterosexual, homosexual, bisexual, or transsexual), schizophrenia, bipolar disorder, and autism spectrum disorder. Such evidence involves the need for a genetic model that includes maternal immunization to explain some of the empirical results reported in the literature. The complex polymorphisms present among the maternally immunizing RH genes can then be used to explain other empirical results. Easily tested hypotheses are suggested, based upon genotypic (but not phenotypic) frequencies of the RH genes. In particular, homozygous dominant individuals are expected to be less common or lacking entirely among the alternative phenotypes. If it is proven that RH genes are involved in brain architecture, it will have a profound effect upon our understanding of the development and organization of the asymmetrical vertebrate brain and may eventually lead to a better understanding of the developmental processes which occur to produce the various alternative phenotypes discussed here. In addition, if RH genes are shown to be involved in the production of these phenotypes, then the evolutionary studies can be performed to demonstrate the beneficial effect of the recessive alleles of RHO and RHCE, and why human evolution appears to be selecting for the recessive alleles even though an increase in the frequency of such alleles may imply lower average fecundity among some individuals possessing them.

  16. The Molecular Basis of Hereditary Enamel Defects in Humans

    Carrion, I.A.; Morris, C.

    2015-01-01

    The formation of human enamel is highly regulated at the molecular level and involves thousands of genes. Requisites for development of this highly mineralized tissue include cell differentiation; production of a unique extracellular matrix; processing of the extracellular matrix; altering of cell function during different stages of enamel formation; cell movement and attachment; regulation of ion and protein movement; and regulation of hydration, pH, and other conditions of the microenvironment, to name just a few. Not surprising, there is a plethora of hereditary conditions with an enamel phenotype. The objective of this review was to identify the hereditary conditions listed on Online Mendelian Inheritance in Man (OMIM) that have an associated enamel phenotype and whether a causative gene has been identified. The OMIM database was searched with the terms amelogenesis, enamel, dental, and tooth, and all results were screened by 2 individuals to determine if an enamel phenotype was identified. Gene and gene product function was reviewed on OMIM and from publications identified in PubMed. The search strategy revealed 91 conditions listed in OMIM as having an enamel phenotype, and of those, 71 have a known molecular etiology or linked genetic loci. The purported protein function of those conditions with a known genetic basis included enzymes, regulatory proteins, extracellular matrix proteins, transcription factors, and transmembrane proteins. The most common enamel phenotype was a deficient amount of enamel, or enamel hypoplasia, with hypomineralization defects being reported less frequently. Knowing these molecular defects allows an initial cataloging of molecular pathways that lead to hereditary enamel defects in humans. This knowledge provides insight into the diverse molecular pathways involved in enamel formation and can be useful when searching for the genetic etiology of hereditary conditions that involve enamel. PMID:25389004

  17. Genetic association, seasonal infections and autoimmune basis of narcolepsy

    Singh, Abinav Kumar; Mahlios, Josh; Mignot, Emmanuel

    2014-01-01

    In recent years, a growing number of potential autoimmune disorders affecting neurons in the central nervous system have been identified, including narcolepsy. Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness with irresistible sleep attacks, cataplexy (sudden bilateral loss of muscle tone), hypnagogic hallucinations, and abnormalities of Rapid Eye Movement sleep. Narcolepsy is generally a sporadic disorder and is caused by the loss of hypocretin (orexin)-producing neurons in the hypothalamus region of the brain. Studies have established that more than 90% of patients have a genetic association with HLA DQB1*06:02. Genome-wide association analysis shows a strong association between narcolepsy and polymorphisms in the TCRα locus and weaker associations within TNFSF4 (also called OX40L), Cathepsin H and the P2RY11-DNMT1 (purinergic receptor subtype P2Y11 to DNMT1, a DNA methytransferase) loci, suggesting an autoimmune basis. Mutations in DNMT1 have also been reported to cause narcolepsy in association with a complex neurological syndrome, suggesting the importance of DNA methylation in the pathology. More recently, narcolepsy was identified in association with seasonal streptococcus, H1N1 infections and following AS03-adjuvanted pH1N1 influenza vaccination in Northern Europe. Potential immunological pathways responsible for the loss of hypocretin producing neurons in these cases may be molecular mimicry or bystander activation. Specific autoantibodies or T cells cross-reactive with hypocretin neurons have not yet been identified, however, thus narcolepsy does not meet Witebsky’s criteria for an autoimmune disease. As the brain is not an easily accessible organ, mechanisms of disease initiation and progression remain a challenge to researchers. PMID:23497937

  18. Further development and data basis for safety and accident analyses of nuclear front end and back end facilities and actualization and revision of calculation methods for nuclear safety analyses. Final report; Weiterentwicklung von Methoden und Datengrundlagen zu Sicherheits- und Stoerfallanalysen fuer Anlagen der nuklearen Ver- und Entsorgung sowie Aktualisierung und Ueberpruefung von Rechenmethoden zu nuklearen Sicherheitsanalysen. Abschlussbericht

    Kilger, Robert; Peters, Elisabeth; Sommer, Fabian; Moser, Eberhard-Franz; Kessen, Sven; Stuke, Maik

    2016-07-15

    This report briefly describes the activities carried out under the project 3613R03350 on the GRS ''Handbook on Accident Analysis for Nuclear Front and Back End Facilities'', and in detail the continuing work on the revision and updating of the GRS ''Handbook on Criticality'', which here focused on fissile systems with plutonium and {sup 233}U. The in previous projects started and ongoing literature study on innovative fuel concepts is continued. Also described are the review and qualification of computational methods by research and active benchmark participation, and the results of tracking the state of science and technology in the field of computational methods for criticality safety analysis. Special in-depth analyzes of selected criticality-relevant occurrences in the past are also documented.

  19. 45 CFR 170.400 - Basis and scope.

    2010-10-01

    ... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Temporary Certification Program for HIT § 170.400 Basis and scope...

  20. Generalized Aliasing as a Basis for Program Analysis Tools

    O'Callahan, Robert

    2000-01-01

    .... This dissertation describes the design of a system, Ajax, that addresses this problem by using semantics-based program analysis as the basis for a number of different tools to aid Java programmers...

  1. Contributions of polarizabilities to four basis polarizations of electromagnetic media

    Bukina, E.N.; Dubovik, V.M.

    1999-01-01

    All contributions to four basis polarizations of an arbitrary electromagnetic medium at the expense of mixed polarizabilities up to fourth rank tensors are presented. Some concrete examples are considered

  2. Management of efficiency of agricultural production on the basis of ...

    Management of efficiency of agricultural production on the basis of margin approach. ... Journal of Fundamental and Applied Sciences ... and systematized to the management of production costs of agricultural products, the proposed definition ...

  3. 47 CFR 64.4000 - Basis and purpose.

    2010-10-01

    ..., termination, and billing of customer telephone service accounts. ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Basis and purpose. 64.4000 Section 64.4000 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) MISCELLANEOUS...

  4. Groebner basis, resultants and the generalized Mandelbrot set

    Geum, Young Hee [Centre of Research for Computational Sciences and Informatics in Biology, Bioindustry, Environment, Agriculture and Healthcare, University of Malaya, 50603 Kuala Lumpur (Malaysia)], E-mail: conpana@empal.com; Hare, Kevin G. [Department of Pure Mathematics, University of Waterloo, Waterloo, Ont., N2L 3G1 (Canada)], E-mail: kghare@math.uwaterloo.ca

    2009-10-30

    This paper demonstrates how the Groebner basis algorithm can be used for finding the bifurcation points in the generalized Mandelbrot set. It also shows how resultants can be used to find components of the generalized Mandelbrot set.

  5. Groebner basis, resultants and the generalized Mandelbrot set

    Geum, Young Hee; Hare, Kevin G.

    2009-01-01

    This paper demonstrates how the Groebner basis algorithm can be used for finding the bifurcation points in the generalized Mandelbrot set. It also shows how resultants can be used to find components of the generalized Mandelbrot set.

  6. Discerning The Motivational Basis For Trade Unionism In Public And ...

    Discerning The Motivational Basis For Trade Unionism In Public And Private ... private businesses are very clear to the actors of industrial relations; those of their ... selfish interests; unions in the public sector ought to function as uplift unions, ...

  7. Weighing the legal basis for housing rights in Zimbabwe | IDRC ...

    2016-12-13

    Dec 13, 2016 ... Weighing the legal basis for housing rights in Zimbabwe ... through the Safe and Inclusive Cities partnership with the UK's Department for International Development. ... Transforming the slum: The case of Mumbai's M-Ward.

  8. Genetic diversity of maize genotypes on the basis of morpho ...

    Genetic diversity of maize genotypes on the basis of morpho-physiological and simple sequence repeat (SSR) markers. Ashish Kumar, Arunita Rakshit, Naresh K Mangilipelli, Y Varalaxmi, T Vijayalakshmi, Jainender M Vanaja, SK Yadav, B Venkateswarlu, M Maheswari ...

  9. Birth registration is the basis for advancing gender equality and ...

    2018-02-22

    Feb 22, 2018 ... Birth registration is the basis for advancing gender equality and children's rights ... family ties and relationships, and an important tool for social protection. ... a health facility or government provider, and enrollment in school.

  10. Simulation of the BWR experiments CORA-17 and CORA-28 using ATHLET-CD and assessment of BWR modelling. 1{sup st} Technical report. Validation and interpretation of the ATHLET-CD model basis; Simulation der SWR-Versuche CORA-17 und CORA-28 mit dem Programmsystem ATHLET-CD und Bewertung der SWR-Modellbasis. 1. Technischer Fachbericht. Validierung und Interpretation der ATHLET-CD Modellbasis

    Hoffmann, M.; Gremme, F.; Koch, M.K.

    2013-08-15

    The 1st Technical Report was prepared for the research project ''Validation and Interpretation of the ATHLET-CD Model Basis'' funded by the Federal Ministry of Economics and Technology (BMWi1501385) and carried out at the Chair of Energy Systems and Energy Economics at Ruhr-Universitaet Bochum (RUB). This report provides results of the simulation of the Boiling Water Reactor (BWR) experiments CORA-17 and -28 with ATHLET-CD Mod. 2.2A. The system code ATHLET-CD (Analysis of Thermal-hydraulics of Leaks and Transients - Core Degradation) is developed by the German Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH. Code results are compared to measurements in order to assess and to analyze the capabilities of the current code version with regard to the modeling of BWR components. The CORA test series was carried out between the years 1987 and 1993 at the former Kernforschungszentrum Karlsruhe (KfK), now Karlsruhe Institute of Technology (KIT). The investigations provided experimental data regarding the material behavior during the early phase of core degradation in Light Water Reactors (LWR). The tests CORA17 and -28 represented a typical BWR arrangement of the fuel rod bundle and provided insights about the bundle behavior during the quenching process (CORA-17) and regarding the influence of a preoxidized bundle (CORA-28), respectively. The simulation results are analyzed and discussed in terms of the thermal bundle behavior, the zirconium oxidation in steam and the resulting hydrogen generation as well as the material relocation. In particular, the recently extended modeling capabilities of the code in terms of the relocation of BWR components like the absorber blade and the canister wall are assessed. The analysis shows that the code captures the thermal behavior in good agreement in both experiments. An even enhanced reproduction of the test CORA-28 is obtained in comparison to a calculation using the previous code version ATHLET-CD Mod

  11. 12 CFR 505.1 - Basis and scope.

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Basis and scope. 505.1 Section 505.1 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FREEDOM OF INFORMATION ACT § 505.1 Basis and scope. (a) This part is issued by the Office of Thrift Supervision (“OTS”) as a supplement to the...

  12. Technical Basis Document for PFP Area Monitoring Dosimetry Program

    Cooper, J R

    2000-01-01

    This document describes the phantom dosimetry used for the PFP Area Monitoring program and establishes the basis for the Plutonium Finishing Plant's (PFP) area monitoring dosimetry program in accordance with the following requirements: Title 10, Code of Federal Regulations (CFR), part 835, ''Occupational Radiation Protection'' Part 835.403; Hanford Site Radiological Control Manual (HSRCM-1), Part 514; HNF-PRO-382, Area Dosimetry Program; and PNL-MA-842, Hanford External Dosimetry Technical Basis Manual.

  13. Assessment of WWER fuel condition in design basis accident

    Bibilashvili, Yu.; Sokolov, N.; Andreeva-Andrievskaya, L.; Vlasov, Yu.; Nechaeva, O.; Salatov, A.

    1994-01-01

    The fuel behaviour in design basis accidents is assessed by means of the verified code RAPTA-5. The code uses a set of high temperature physico-chemical properties of the fuel components as determined for commercially produced materials, fuel rod simulators and fuel rod bundles. The WWER fuel criteria available in Russia for design basis accidents do not generally differ from the similar criteria adopted for PWR's. 12 figs., 11 refs

  14. PFP total operating efficiency calculation and basis of estimate

    SINCLAIR, J.C.

    1999-01-01

    The purpose of the Plutonium Finishing Plant (PFP) Total Operating Efficiency Calculation and Basis of Estimate document is to provide the calculated value and basis of estimate for the Total Operating Efficiency (TOE) for the material stabilization operations to be conducted in 234-52 Building. This information will be used to support both the planning and execution of the Plutonium Finishing Plant (PFP) Stabilization and Deactivation Project's (hereafter called the Project) resource-loaded, integrated schedule

  15. Cellular Basis for ADT-Induced Acceleration of Sarcopenia

    2015-10-01

    1 AWARD NUMBER: W81XWH-14-1-0454 TITLE: Cellular Basis for ADT-Induced Acceleration of Sarcopenia PRINCIPAL INVESTIGATOR: Joe V...AND SUBTITLE Cellular Basis for ADT-Induced Acceleration of Sarcopenia 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-14-1-0454 5c. PROGRAM...cell function and thereby regenerative capability contribute to the acceleration of sarcopenia observed in prostate cancer patients undergoing ADT

  16. The finite element method its basis and fundamentals

    Zienkiewicz, Olek C; Zhu, JZ

    2013-01-01

    The Finite Element Method: Its Basis and Fundamentals offers a complete introduction to the basis of the finite element method, covering fundamental theory and worked examples in the detail required for readers to apply the knowledge to their own engineering problems and understand more advanced applications. This edition sees a significant rearrangement of the book's content to enable clearer development of the finite element method, with major new chapters and sections added to cover: Weak forms Variational forms Multi-dimensional field prob

  17. The Oblique Basis Method from an Engineering Point of View

    Gueorguiev, V G

    2012-01-01

    The oblique basis method is reviewed from engineering point of view related to vibration and control theory. Examples are used to demonstrate and relate the oblique basis in nuclear physics to the equivalent mathematical problems in vibration theory. The mathematical techniques, such as principal coordinates and root locus, used by vibration and control theory engineers are shown to be relevant to the Richardson - Gaudin pairing-like problems in nuclear physics.

  18. Technical Basis Document for PFP Area Monitoring Dosimetry Program

    COOPER, J.R.

    2000-01-01

    This document describes the phantom dosimetry used for the PFP Area Monitoring program and establishes the basis for the Plutonium Finishing Plant's (PFP) area monitoring dosimetry program in accordance with the following requirements: Title 10, Code of Federal Regulations (CFR), part 835, ''Occupational Radiation Protection'' Part 835.403; Hanford Site Radiological Control Manual (HSRCM-1), Part 514; HNF-PRO-382, Area Dosimetry Program; and PNL-MA-842, Hanford External Dosimetry Technical Basis Manual

  19. The pointer basis and the feedback stabilization of quantum systems

    Li, L; Chia, A; Wiseman, H M

    2014-01-01

    The dynamics for an open quantum system can be ‘unravelled’ in infinitely many ways, depending on how the environment is monitored, yielding different sorts of conditioned states, evolving stochastically. In the case of ideal monitoring these states are pure, and the set of states for a given monitoring forms a basis (which is overcomplete in general) for the system. It has been argued elsewhere (Atkins et al 2005 Europhys. Lett. 69 163) that the ‘pointer basis’ as introduced by Zurek et al (1993 Phys. Rev. Lett. 70 1187), should be identified with the unravelling-induced basis which decoheres most slowly. Here we show the applicability of this concept of pointer basis to the problem of state stabilization for quantum systems. In particular we prove that for linear Gaussian quantum systems, if the feedback control is assumed to be strong compared to the decoherence of the pointer basis, then the system can be stabilized in one of the pointer basis states with a fidelity close to one (the infidelity varies inversely with the control strength). Moreover, if the aim of the feedback is to maximize the fidelity of the unconditioned system state with a pure state that is one of its conditioned states, then the optimal unravelling for stabilizing the system in this way is that which induces the pointer basis for the conditioned states. We illustrate these results with a model system: quantum Brownian motion. We show that even if the feedback control strength is comparable to the decoherence, the optimal unravelling still induces a basis very close to the pointer basis. However if the feedback control is weak compared to the decoherence, this is not the case. (paper)

  20. Assessment of WWER fuel condition in design basis accident

    Bibilashvili, Yu; Sokolov, N; Andreeva-Andrievskaya, L; Vlasov, Yu; Nechaeva, O; Salatov, A [Vsesoyuznyj Nauchno-Issledovatel` skij Inst. Neorganicheskikh Materialov, Moscow (Russian Federation)

    1994-12-31

    The fuel behaviour in design basis accidents is assessed by means of the verified code RAPTA-5. The code uses a set of high temperature physico-chemical properties of the fuel components as determined for commercially produced materials, fuel rod simulators and fuel rod bundles. The WWER fuel criteria available in Russia for design basis accidents do not generally differ from the similar criteria adopted for PWR`s. 12 figs., 11 refs.

  1. Identification and Structural Basis of Binding to Host Lung Glycogen by Streptococcal Virulence Factors

    Lammerts van Bueren,A.; Higgins, M.; Wang, D.; Burke, R.; Boraston, A.

    2007-01-01

    The ability of pathogenic bacteria to recognize host glycans is often essential to their virulence. Here we report structure-function studies of previously uncharacterized glycogen-binding modules in the surface-anchored pullulanases from Streptococcus pneumoniae (SpuA) and Streptococcus pyogenes (PulA). Multivalent binding to glycogen leads to a strong interaction with alveolar type II cells in mouse lung tissue. X-ray crystal structures of the binding modules reveal a novel fusion of tandem modules into single, bivalent functional domains. In addition to indicating a structural basis for multivalent attachment, the structure of the SpuA modules in complex with carbohydrate provides insight into the molecular basis for glycogen specificity. This report provides the first evidence that intracellular lung glycogen may be a novel target of pathogenic streptococci and thus provides a rationale for the identification of the streptococcal {alpha}-glucan-metabolizing machinery as virulence factors.

  2. Basic research on energy conservation in developing countries. Joint research on oil conservation (research report on the industrial basis of Socialist Republic of Vietnam); Hatten tojokoku energy shohi koritsuka kiso chosanado jigyo sekiyu shohi koritsuka kyoryoku chosa. Betonamu shakai shugi kyowakoku sangyo kiso chosa hokokusho

    NONE

    1996-03-01

    The field research of oil conservation was conducted in developing countries, in particular, Vietnam where a steep increase in oil consumption is anticipated in the future. Energy conservation is the most effective direct measures to control combustion of fossil fuels, and an important issue to be promoted by all countries in the world to prevent global warming and reserve energy resources. In fiscal 1994, main industries in the northern part of Vietnam were researched. In fiscal 1995, the report meeting of plant survey results in the northern part and the technical seminar of energy-saving in industrial field were held, and plants around Ho Chi Minh City in the southern part of Vietnam were researched. Although Vietnam has recently acquired membership in ASEAN and is undergoing dramatic economic growth, has many problems in environmental measures. Japan has top-ranking results on energy-saving in industrial field, and the transfer of such superior technologies and techniques will greatly contribute to resource and global warming problems as well as pollution control measures in Vietnam. 13 refs., 25 figs., 26 tabs.

  3. The genetic basis of pectoralis major myopathies in modern broiler chicken lines

    Bailey, Richard A.; Watson, Kellie A.; Bilgili, S. F.; Avendano, Santiago

    2015-01-01

    This is the first report providing estimates of the genetic basis of breast muscle myopathies (BMM) and their relationship with growth and yield in broiler chickens. In addition, this paper addresses the hypothesis that genetic selection for increase breast yield has contributed to the onset of BMM. Data were analyzed from ongoing recording of BMM within the Aviagen breeding program. This study focused on three BMM: deep pectoral myopathy (DPM; binary trait), white striping (WS; 4 categories)...

  4. A probabilistic risk assessment of the LLNL Plutonium facility's evaluation basis fire operational accident

    Brumburgh, G.

    1994-01-01

    The Lawrence Livermore National Laboratory (LLNL) Plutonium Facility conducts numerous involving plutonium to include device fabrication, development of fabrication techniques, metallurgy research, and laser isotope separation. A Safety Analysis Report (SAR) for the building 332 Plutonium Facility was completed rational safety and acceptable risk to employees, the public, government property, and the environment. This paper outlines the PRA analysis of the Evaluation Basis Fire (EDF) operational accident. The EBF postulates the worst-case programmatic impact event for the Plutonium Facility

  5. Technical basis for nuclear accident dosimetry at the Oak Ridge National Laboratory

    Kerr, G.D.; Mei, G.T.

    1993-08-01

    The Oak Ridge National Laboratory (ORNL) Environmental, Safety, and Health Emergency Response Organization has the responsibility of providing analyses of personnel exposures to neutrons and gamma rays from a nuclear accident. This report presents the technical and philosophical basis for the dose assessment aspects of the nuclear accident dosimetry (NAD) system at ORNL. The issues addressed are regulatory guidelines, ORNL NAD system components and performance, and the interpretation of dosimetric information that would be gathered following a nuclear accident

  6. Ground motion following selection of SRS design basis earthquake and associated deterministic approach

    1991-03-01

    This report summarizes the results of a deterministic assessment of earthquake ground motions at the Savannah River Site (SRS). The purpose of this study is to assist the Environmental Sciences Section of the Savannah River Laboratory in reevaluating the design basis earthquake (DBE) ground motion at SRS during approaches defined in Appendix A to 10 CFR Part 100. This work is in support of the Seismic Engineering Section's Seismic Qualification Program for reactor restart

  7. Recommendation for basis for decision on a Danish ultimate storage for low and intermediate radioactive wastes

    2006-12-01

    In 2003 the Danish Parliament consented to let the government start the preparation of a basis for decision on a Danish ultimate storage for low and intermediate radioactive wastes. The present report is the result of the preparation process, and it describes the fundamental safety and environmental principles for establishing an ultimate storage, including determining the principles for the site selection, storage construction, and safety analyses. (LN)

  8. Theoretical basis for a transient thermal elastic-plastic stress analysis of nuclear reactor fuel elements

    Hsu, T.R.; Bertels, A.W.M.; Banerjee, S.; Harrison, W.C.

    1976-07-01

    This report presents the theoretical basis for a transient thermal elastic-plastic stress analysis of a nuclear reactor fuel element subject to severe transient thermo-mechanical loading. A finite element formulation is used for both the non-linear stress analysis and thermal analysis. These two major components are linked together to form an integrated program capable of predicting fuel element transient behaviour in two dimensions. Specific case studies are presented to illustrate capabilities of the analysis. (author)

  9. Super-leading logarithms in non-global observables in QCD colour basis independent calculation

    Forshaw, J R; Seymour, M H

    2008-01-01

    In a previous paper we reported the discovery of super-leading logarithmic terms in a non-global QCD observable. In this short update we recalculate the first super-leading logarithmic contribution to the 'gaps between jets' cross-section using a colour basis independent notation. This sheds light on the structure and origin of the super-leading terms and allows them to be calculated for gluon scattering processes for the first time.

  10. Report on gas sales regulated tariffs of historical providers (others than GDF Suez). Analysis of supply costs and of non-supply related costs - May 2015. Deliberation of the Commission for Energy Regulation of the 27 May 2015 bearing approval of the report of analysis of supply and non-supply related costs used as a basis for the calculation of the evolution of natural gas sales regulated tariffs of historical providers

    Edwige, Catherine; Padova, Yann; Sotura, Jean-Pierre

    2015-05-01

    After a presentation of the context and objectives of works performed by the CRE (the French commission for energy regulation), and a synthetic presentation of the main conclusions, this report first proposes an assessment for 2014 by presenting and discussing the distribution of costs taken into account in regulated tariffs of historic providers, and by noticing that the CRE is able to give its opinion on cost coverage by revenues only for a limited number of providers. The second part proposes an analysis of provider supply conditions and their evolution perspectives. The last part addresses the perspectives of evolution of non-supply related costs

  11. Basis set construction for molecular electronic structure theory: natural orbital and Gauss-Slater basis for smooth pseudopotentials.

    Petruzielo, F R; Toulouse, Julien; Umrigar, C J

    2011-02-14

    A simple yet general method for constructing basis sets for molecular electronic structure calculations is presented. These basis sets consist of atomic natural orbitals from a multiconfigurational self-consistent field calculation supplemented with primitive functions, chosen such that the asymptotics are appropriate for the potential of the system. Primitives are optimized for the homonuclear diatomic molecule to produce a balanced basis set. Two general features that facilitate this basis construction are demonstrated. First, weak coupling exists between the optimal exponents of primitives with different angular momenta. Second, the optimal primitive exponents for a chosen system depend weakly on the particular level of theory employed for optimization. The explicit case considered here is a basis set appropriate for the Burkatzki-Filippi-Dolg pseudopotentials. Since these pseudopotentials are finite at nuclei and have a Coulomb tail, the recently proposed Gauss-Slater functions are the appropriate primitives. Double- and triple-zeta bases are developed for elements hydrogen through argon. These new bases offer significant gains over the corresponding Burkatzki-Filippi-Dolg bases at various levels of theory. Using a Gaussian expansion of the basis functions, these bases can be employed in any electronic structure method. Quantum Monte Carlo provides an added benefit: expansions are unnecessary since the integrals are evaluated numerically.

  12. Efficient computation of smoothing splines via adaptive basis sampling

    Ma, Ping

    2015-06-24

    © 2015 Biometrika Trust. Smoothing splines provide flexible nonparametric regression estimators. However, the high computational cost of smoothing splines for large datasets has hindered their wide application. In this article, we develop a new method, named adaptive basis sampling, for efficient computation of smoothing splines in super-large samples. Except for the univariate case where the Reinsch algorithm is applicable, a smoothing spline for a regression problem with sample size n can be expressed as a linear combination of n basis functions and its computational complexity is generally O(n3). We achieve a more scalable computation in the multivariate case by evaluating the smoothing spline using a smaller set of basis functions, obtained by an adaptive sampling scheme that uses values of the response variable. Our asymptotic analysis shows that smoothing splines computed via adaptive basis sampling converge to the true function at the same rate as full basis smoothing splines. Using simulation studies and a large-scale deep earth core-mantle boundary imaging study, we show that the proposed method outperforms a sampling method that does not use the values of response variables.

  13. Efficient computation of smoothing splines via adaptive basis sampling

    Ma, Ping; Huang, Jianhua Z.; Zhang, Nan

    2015-01-01

    © 2015 Biometrika Trust. Smoothing splines provide flexible nonparametric regression estimators. However, the high computational cost of smoothing splines for large datasets has hindered their wide application. In this article, we develop a new method, named adaptive basis sampling, for efficient computation of smoothing splines in super-large samples. Except for the univariate case where the Reinsch algorithm is applicable, a smoothing spline for a regression problem with sample size n can be expressed as a linear combination of n basis functions and its computational complexity is generally O(n3). We achieve a more scalable computation in the multivariate case by evaluating the smoothing spline using a smaller set of basis functions, obtained by an adaptive sampling scheme that uses values of the response variable. Our asymptotic analysis shows that smoothing splines computed via adaptive basis sampling converge to the true function at the same rate as full basis smoothing splines. Using simulation studies and a large-scale deep earth core-mantle boundary imaging study, we show that the proposed method outperforms a sampling method that does not use the values of response variables.

  14. Proposal for a novel management of indeterminate thyroid nodules on the basis of cytopathological subclasses.

    Rossi, Martina; Lupo, Sabrina; Rossi, Roberta; Franceschetti, Paola; Trasforini, Giorgio; Bruni, Stefania; Tagliati, Federico; Buratto, Mattia; Lanza, Giovanni; Damiani, Luca; Degli Uberti, Ettore; Zatelli, Maria Chiara

    2017-07-01

    Indeterminate thyroid nodules include heterogeneous lesions that could benefit from a differential management. Our aim is to better define the management of the Bethesda System for Reporting Thyroid Cytopathology class III and IV nodules, by identifying cytological subcategories among Bethesda System for Reporting Thyroid Cytopathology class III associated with different clinical risk, by means of ultrasound, repeated FNAB, and BRAFV600E molecular analysis. We also evaluated the outcome of nodules not operated, over a 5-year follow-up. Out of 460 nodules (269 Bethesda System for Reporting Thyroid Cytopathology class III and 191 Bethesda System for Reporting Thyroid Cytopathology class IV), 344 were operated on surgical group and 116 followed-up conservatively (follow-up group). Bethesda System for Reporting Thyroid Cytopathology class III was divided into four subcategories on the basis of cytomorphological features (III-1, III-2, III-3, III-4). Clinical risk was defined on the basis of histological, cytological, and ultrasound data. Malignancy was higher in Bethesda System for Reporting Thyroid Cytopathology class III vs. Bethesda System for Reporting Thyroid Cytopathology class IV (34.4 vs. 26.2 %; p management of Bethesda System for Reporting Thyroid Cytopathology III and IV classes and related subcategories: surgery may be indicated in Bethesda System for Reporting Thyroid Cytopathology class III-1, III-4, and IV; a conservative follow-up avoiding repeated FNAB may be appropriated in class III-3, while repeated FNAB may be useful in class III-2.

  15. Point Set Denoising Using Bootstrap-Based Radial Basis Function.

    Khang Jie Liew

    Full Text Available This paper examines the application of a bootstrap test error estimation of radial basis functions, specifically thin-plate spline fitting, in surface smoothing. The presence of noisy data is a common issue of the point set model that is generated from 3D scanning devices, and hence, point set denoising is one of the main concerns in point set modelling. Bootstrap test error estimation, which is applied when searching for the smoothing parameters of radial basis functions, is revisited. The main contribution of this paper is a smoothing algorithm that relies on a bootstrap-based radial basis function. The proposed method incorporates a k-nearest neighbour search and then projects the point set to the approximated thin-plate spline surface. Therefore, the denoising process is achieved, and the features are well preserved. A comparison of the proposed method with other smoothing methods is also carried out in this study.

  16. Point Set Denoising Using Bootstrap-Based Radial Basis Function.

    Liew, Khang Jie; Ramli, Ahmad; Abd Majid, Ahmad

    2016-01-01

    This paper examines the application of a bootstrap test error estimation of radial basis functions, specifically thin-plate spline fitting, in surface smoothing. The presence of noisy data is a common issue of the point set model that is generated from 3D scanning devices, and hence, point set denoising is one of the main concerns in point set modelling. Bootstrap test error estimation, which is applied when searching for the smoothing parameters of radial basis functions, is revisited. The main contribution of this paper is a smoothing algorithm that relies on a bootstrap-based radial basis function. The proposed method incorporates a k-nearest neighbour search and then projects the point set to the approximated thin-plate spline surface. Therefore, the denoising process is achieved, and the features are well preserved. A comparison of the proposed method with other smoothing methods is also carried out in this study.

  17. The Evidential Basis of Decision Making in Plant Disease Management.

    Hughes, Gareth

    2017-08-04

    The evidential basis for disease management decision making is provided by data relating to risk factors. The decision process involves an assessment of the evidence leading to taking (or refraining from) action on the basis of a prediction. The primary objective of the decision process is to identify-at the time the decision is made-the control action that provides the best predicted end-of-season outcome, calculated in terms of revenue or another appropriate metric. Data relating to disease risk factors may take a variety of forms (e.g., continuous, discrete, categorical) on measurement scales in a variety of units. Log 10 -likelihood ratios provide a principled basis for the accumulation of evidence based on such data and allow predictions to be made via Bayesian updating of prior probabilities.

  18. Interim safety basis compliance matrix for Trenches 31 and 34

    Ames, R.R.

    1994-01-01

    The tables provided in this document identify the specific requirements and basis for the administrative controls established in the Westinghouse Hanford Company (WHC) Solid Waste Burial Ground (SWBG) Interim Safety Basis (ISB) for operation of the Project W-025, Mixed Waste Lined Landfill (Trenches 31 and 34). The tables document the necessary controls and implementing procedures to ensure compliance with the requirements of the ISB. These requirements provide a basis for future Unreviewed Safety Questions (USQ) screening of applicable procedure changes, proposed physical modifications, tests, experiments, and occurrences. Table 1 provides the SWBG interim Operational Safety Requirements administrative controls matrix. The specific assumptions and commitments used in the safety analysis documents applicable to disposal of mixed wastes in Trenches 31 and 34 are provided in Table 2. Table 3 is provided to document the potential engineered and administrative mitigating features identified in the Preliminary Hazard Analysis (PHA) for disposal of mixed waste

  19. Simulant Basis for the Standard High Solids Vessel Design

    Peterson, Reid A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fiskum, Sandra K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Suffield, Sarah R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Daniel, Richard C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gauglitz, Phillip A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wells, Beric E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-09-30

    The Waste Treatment and Immobilization Plant (WTP) is working to develop a Standard High Solids Vessel Design (SHSVD) process vessel. To support testing of this new design, WTP engineering staff requested that a Newtonian simulant and a non-Newtonian simulant be developed that would represent the Most Adverse Design Conditions (in development) with respect to mixing performance as specified by WTP. The majority of the simulant requirements are specified in 24590-PTF-RPT-PE-16-001, Rev. 0. The first step in this process is to develop the basis for these simulants. This document describes the basis for the properties of these two simulant types. The simulant recipes that meet this basis will be provided in a subsequent document.

  20. Speech/Nonspeech Detection Using Minimal Walsh Basis Functions

    Pwint Moe

    2007-01-01

    Full Text Available This paper presents a new method to detect speech/nonspeech components of a given noisy signal. Employing the combination of binary Walsh basis functions and an analysis-synthesis scheme, the original noisy speech signal is modified first. From the modified signals, the speech components are distinguished from the nonspeech components by using a simple decision scheme. Minimal number of Walsh basis functions to be applied is determined using singular value decomposition (SVD. The main advantages of the proposed method are low computational complexity, less parameters to be adjusted, and simple implementation. It is observed that the use of Walsh basis functions makes the proposed algorithm efficiently applicable in real-world situations where processing time is crucial. Simulation results indicate that the proposed algorithm achieves high-speech and nonspeech detection rates while maintaining a low error rate for different noisy conditions.

  1. Report on gas sales regulated tariffs of GDF Suez. Audit of supply costs and of non-supply related costs - May 2015. Deliberation of the Commission for Energy Regulation of the 13 May 2015 bearing approval of the report of analysis of supply and non-supply related costs used as a basis for the calculation of the evolution of natural gas sales regulated tariffs of GDF Suez

    Gassin, Helene; Padova, Yann; Sotura, Jean-Pierre; Monteil, Anne; Casadei, Cecile

    2015-05-01

    After a presentation of the context and objectives of works performed by the CRE (the French commission for energy regulation), and a synthetic presentation of the main conclusions, this report first proposes an assessment for 2014 by presenting and discussing the fact that regulated tariffs have followed a downward trend since the beginning of 2014, that sales at regulated tariffs have strongly decreased, and that GDF Suez costs have been covered by revenues from sales at regulated tariffs. The second part proposes an analysis of the evolution perspectives for supply costs by commenting the calculation formula, the difference between gas market price and LT contract prices, the always stronger indexing of contracts on gas market prices. The last part addresses the perspectives of evolution of non-supply related costs by commenting the taking of infrastructure cost evolution into account, the steadiness of provisional commercial costs, and the consequence of the customer portfolio evolution on the distribution of commercial force costs. Some recommendations are made on the evolution perspectives for supply and non-supply related costs, and on the modalities of assignment of commercial costs among the different types of customers (regulated tariffs or market price)

  2. Report on ENGIE's regulated tariffs for gas sale - Audit supply costs and non-supply related costs. Deliberation of the Commission for energy regulation on the 25 May 2016 bearing approval of the audit report on supply costs and non-supply related costs as basis for the calculation of the evolution of ENGIE's regulated tariffs for natural gas sale

    Ladoucette, Philippe De; Edwige, Catherine; Gassin, Helene; Padova, Yann; Sotura, Jean-Pierre

    2016-05-01

    After a recall of the context and objectives of the analysis performed by the French Commission for Energy Regulation (CRE), and a synthetic presentation of the main conclusions, this report first proposes an assessment for 2015 by discussing the share of consumptions provided under the regulated tariff with respect to those provided on the retail market, the evolution of these tariffs, by noticing that ENGIE costs have been covered by income associated with sales at regulated tariffs. The second part addresses perspectives of evolution for supply costs by outlining the existence of market indexing, the lack of factors which would justify an evolution of gas price indexing level, and a possible reviewing of indices at the moment of revision of the indexing formula. The third part addresses the perspectives of evolution of non-supply related costs. It notices the impact of recent evolution of infrastructure costs, some lack of information regarding provisional trade costs, and a significant decrease of these costs for 2016

  3. Empirical projection-based basis-component decomposition method

    Brendel, Bernhard; Roessl, Ewald; Schlomka, Jens-Peter; Proksa, Roland

    2009-02-01

    Advances in the development of semiconductor based, photon-counting x-ray detectors stimulate research in the domain of energy-resolving pre-clinical and clinical computed tomography (CT). For counting detectors acquiring x-ray attenuation in at least three different energy windows, an extended basis component decomposition can be performed in which in addition to the conventional approach of Alvarez and Macovski a third basis component is introduced, e.g., a gadolinium based CT contrast material. After the decomposition of the measured projection data into the basis component projections, conventional filtered-backprojection reconstruction is performed to obtain the basis-component images. In recent work, this basis component decomposition was obtained by maximizing the likelihood-function of the measurements. This procedure is time consuming and often unstable for excessively noisy data or low intrinsic energy resolution of the detector. Therefore, alternative procedures are of interest. Here, we introduce a generalization of the idea of empirical dual-energy processing published by Stenner et al. to multi-energy, photon-counting CT raw data. Instead of working in the image-domain, we use prior spectral knowledge about the acquisition system (tube spectra, bin sensitivities) to parameterize the line-integrals of the basis component decomposition directly in the projection domain. We compare this empirical approach with the maximum-likelihood (ML) approach considering image noise and image bias (artifacts) and see that only moderate noise increase is to be expected for small bias in the empirical approach. Given the drastic reduction of pre-processing time, the empirical approach is considered a viable alternative to the ML approach.

  4. SAFETY BASIS DESIGN DEVELOPMENT CHALLENGES IMECE2007-42747

    RYAN GW

    2007-01-01

    'Designing in Safety' is a desired part of the development of any new potentially hazardous system, process, or facility. It is a required part of nuclear safety activities as specified in the U.S. Department of Energy (DOE) Order 420.B, Facility Safety. This order addresses the design of nuclear related facilities developed under federal regulation IOCFR830, Nuclear Safety Management. IOCFR830 requires that safety basis documentation be provided to identify how nuclear safety is being adequately addressed as a condition for system operation (e.g., the safety basis). To support the development of the safety basis, a safety analysis is performed. Although the concept of developing a design that addresses 'Safety is simple, the execution can be complex and challenging. This paper addresses those complexities and challenges for the design activity of a system to treat sludge, a corrosion product of spent nuclear fuel, at DOE's Hanford Site in Washington State. The system being developed is referred to as the Sludge Treatment Project (STP). This paper describes the portion of the safety analysis that addresses the selection of design basis events using the experience gained from the STP and the development of design requirements for safety features associated with those events. Specifically, the paper describes the safety design process and the application of the process for two types of potential design basis accidents associated with the operation of the system, (1) flashing spray leaks and (2) splash and splatter leaks. Also presented are the technical challenges that are being addressed to develop effective safety features to deal with these design basis accidents

  5. SAFETY BASIS DESIGN DEVELOPMENT CHALLENGES IMECE2007-42747

    RYAN GW

    2007-09-24

    'Designing in Safety' is a desired part of the development of any new potentially hazardous system, process, or facility. It is a required part of nuclear safety activities as specified in the U.S. Department of Energy (DOE) Order 420.B, Facility Safety. This order addresses the design of nuclear related facilities developed under federal regulation IOCFR830, Nuclear Safety Management. IOCFR830 requires that safety basis documentation be provided to identify how nuclear safety is being adequately addressed as a condition for system operation (e.g., the safety basis). To support the development of the safety basis, a safety analysis is performed. Although the concept of developing a design that addresses 'Safety is simple, the execution can be complex and challenging. This paper addresses those complexities and challenges for the design activity of a system to treat sludge, a corrosion product of spent nuclear fuel, at DOE's Hanford Site in Washington State. The system being developed is referred to as the Sludge Treatment Project (STP). This paper describes the portion of the safety analysis that addresses the selection of design basis events using the experience gained from the STP and the development of design requirements for safety features associated with those events. Specifically, the paper describes the safety design process and the application of the process for two types of potential design basis accidents associated with the operation of the system, (1) flashing spray leaks and (2) splash and splatter leaks. Also presented are the technical challenges that are being addressed to develop effective safety features to deal with these design basis accidents.

  6. PFP total process throughput calculation and basis of estimate

    SINCLAIR, J.C.

    1999-01-01

    The PFP Process Throughput Calculation and Basis of Estimate document provides the calculated value and basis of estimate for process throughput associated with material stabilization operations conducted in 234-52 Building. The process throughput data provided reflects the best estimates of material processing rates consistent with experience at the Plutonium Finishing Plant (PFP) and other U.S. Department of Energy (DOE) sites. The rates shown reflect demonstrated capacity during ''full'' operation. They do not reflect impacts of building down time. Therefore, these throughput rates need to have a Total Operating Efficiency (TOE) factor applied

  7. Gaussian basis functions for highly oscillatory scattering wavefunctions

    Mant, B. P.; Law, M. M.

    2018-04-01

    We have applied a basis set of distributed Gaussian functions within the S-matrix version of the Kohn variational method to scattering problems involving deep potential energy wells. The Gaussian positions and widths are tailored to the potential using the procedure of Bačić and Light (1986 J. Chem. Phys. 85 4594) which has previously been applied to bound-state problems. The placement procedure is shown to be very efficient and gives scattering wavefunctions and observables in agreement with direct numerical solutions. We demonstrate the basis function placement method with applications to hydrogen atom–hydrogen atom scattering and antihydrogen atom–hydrogen atom scattering.

  8. Technical Basis Document for PFP Area Monitoring Dosimetry Program

    COOPER, J.R.

    2000-04-17

    This document describes the phantom dosimetry used for the PFP Area Monitoring program and establishes the basis for the Plutonium Finishing Plant's (PFP) area monitoring dosimetry program in accordance with the following requirements: Title 10, Code of Federal Regulations (CFR), part 835, ''Occupational Radiation Protection'' Part 835.403; Hanford Site Radiological Control Manual (HSRCM-1), Part 514; HNF-PRO-382, Area Dosimetry Program; and PNL-MA-842, Hanford External Dosimetry Technical Basis Manual.

  9. Scientific basis for a safety case of deep geological repositories

    Noseck, Ulrich; Becker, Dirk-Alexander; Brasser, Thomas [and others

    2012-11-15

    Within this project strategies and methods to build a safety case for deep geological repositories are further developed. This includes also the scientific fundamentals as a basis of the safety case. In the international framework the methodology of the Safety Case is frequently applied and continuously improved. According to definitions from IAEA and NEA the Safety Case is a compilation of arguments and facts, which describe, quantify and support the safety and the degree of confidence in the safety of the geological repository. The safety of the geological repository should be demonstrated by the safety case. The safety case is the basis for essential decisions during a repository programme. It comprises the results of safety assessments in combination with additional information like multiple lines of evidence and a discussion of robustness and quality of the repository, its design and the quality of all safety assessments including the basic assumptions. A crucial element of the Safety Case is the long-term safety analysis, i.e. the systematic analysis of the hazards connected with the facility and the capability of site and repository design to ensure the required safety functions and to fulfill the technical claims. Long-term safety analysis requires a powerful and qualified programme package, which contains appropriate hardware and software as well as well trained and experienced modellers performing the model calculations. The calculation tools used within safety cases need to be checked and verified and continuously adapted to the state-of-the-art science and technology. Especially it needs to be applicable to a real repository system. For the assessment of safety a deep process understanding is necessary. The R and D work performed within this project will contribute to the improvement of process and system understanding as well as to the further development of methods and strategies applied in the safety case. Emphasis was put on the following aspects

  10. Scientific basis for a safety case of deep geological repositories

    Noseck, Ulrich; Becker, Dirk-Alexander; Brasser, Thomas

    2012-11-01

    Within this project strategies and methods to build a safety case for deep geological repositories are further developed. This includes also the scientific fundamentals as a basis of the safety case. In the international framework the methodology of the Safety Case is frequently applied and continuously improved. According to definitions from IAEA and NEA the Safety Case is a compilation of arguments and facts, which describe, quantify and support the safety and the degree of confidence in the safety of the geological repository. The safety of the geological repository should be demonstrated by the safety case. The safety case is the basis for essential decisions during a repository programme. It comprises the results of safety assessments in combination with additional information like multiple lines of evidence and a discussion of robustness and quality of the repository, its design and the quality of all safety assessments including the basic assumptions. A crucial element of the Safety Case is the long-term safety analysis, i.e. the systematic analysis of the hazards connected with the facility and the capability of site and repository design to ensure the required safety functions and to fulfill the technical claims. Long-term safety analysis requires a powerful and qualified programme package, which contains appropriate hardware and software as well as well trained and experienced modellers performing the model calculations. The calculation tools used within safety cases need to be checked and verified and continuously adapted to the state-of-the-art science and technology. Especially it needs to be applicable to a real repository system. For the assessment of safety a deep process understanding is necessary. The R and D work performed within this project will contribute to the improvement of process and system understanding as well as to the further development of methods and strategies applied in the safety case. Emphasis was put on the following aspects

  11. Real-space local polynomial basis for solid-state electronic-structure calculations: A finite-element approach

    Pask, J.E.; Klein, B.M.; Fong, C.Y.; Sterne, P.A.

    1999-01-01

    We present an approach to solid-state electronic-structure calculations based on the finite-element method. In this method, the basis functions are strictly local, piecewise polynomials. Because the basis is composed of polynomials, the method is completely general and its convergence can be controlled systematically. Because the basis functions are strictly local in real space, the method allows for variable resolution in real space; produces sparse, structured matrices, enabling the effective use of iterative solution methods; and is well suited to parallel implementation. The method thus combines the significant advantages of both real-space-grid and basis-oriented approaches and so promises to be particularly well suited for large, accurate ab initio calculations. We develop the theory of our approach in detail, discuss advantages and disadvantages, and report initial results, including electronic band structures and details of the convergence of the method. copyright 1999 The American Physical Society

  12. Optimal choice of basis functions in the linear regression analysis

    Khotinskij, A.M.

    1988-01-01

    Problem of optimal choice of basis functions in the linear regression analysis is investigated. Step algorithm with estimation of its efficiency, which holds true at finite number of measurements, is suggested. Conditions, providing the probability of correct choice close to 1 are formulated. Application of the step algorithm to analysis of decay curves is substantiated. 8 refs

  13. Basis and rational for standardization in radiation protection

    Besar, Idris

    1985-08-01

    The historical background for the standardization in radiation protection with special reference to the dose limits recommended by the ICRP which include tolerance dose, maximum permissible dose, and the present recommendation based on the ICRP 26 are presented. The basis and rational for the establishment of these limits are discussed.

  14. Application of radial basis neural network for state estimation of ...

    An original application of radial basis function (RBF) neural network for power system state estimation is proposed in this paper. The property of massive parallelism of neural networks is employed for this. The application of RBF neural network for state estimation is investigated by testing its applicability on a IEEE 14 bus ...

  15. Seismic methodology in determining basis earthquake for nuclear installation

    Ameli Zamani, Sh.

    2008-01-01

    Design basis earthquake ground motions for nuclear installations should be determined to assure the design purpose of reactor safety: that reactors should be built and operated to pose no undue risk to public health and safety from earthquake and other hazards. Regarding the influence of seismic hazard to a site, large numbers of earthquake ground motions can be predicted considering possible variability among the source, path, and site parameters. However, seismic safety design using all predicted ground motions is practically impossible. In the determination of design basis earthquake ground motions it is therefore important to represent the influences of the large numbers of earthquake ground motions derived from the seismic ground motion prediction methods for the surrounding seismic sources. Viewing the relations between current design basis earthquake ground motion determination and modem earthquake ground motion estimation, a development of risk-informed design basis earthquake ground motion methodology is discussed for insight into the on going modernization of the Examination Guide for Seismic Design on NPP

  16. 7 CFR 330.102 - Basis for certain regulations.

    2010-01-01

    ... of the Plant Protection Act, the Secretary may prohibit or restrict the importation, entry... 7 Agriculture 5 2010-01-01 2010-01-01 false Basis for certain regulations. 330.102 Section 330.102 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION...

  17. Conceptual basis for developing of trainig models in complex ...

    This paper presents conceptual basis for developing of training models of interactive assembling system for automatic building of application software systems, ... software generation, such as: program module compatibility, formalization of computer interaction and choosing of formal model for human machine interface.

  18. 50 CFR 18.70 - Basis and purpose.

    2010-10-01

    ... importing of animals from each species of marine mammals under his jurisdiction; and (3) prescribe... PLANTS (CONTINUED) MARINE MAMMALS Notice and Hearing on Section 103 Regulations § 18.70 Basis and purpose. (a) Sections 101(a)(2), 101(a)(3)(A), and 101(b) of the Marine Mammal Protection Act of 1972 (16 U.S...

  19. 50 CFR 228.1 - Basis and purpose.

    2010-10-01

    ... regulations with respect to the taking and importing of animals from each species of marine mammals under the... Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS NOTICE AND HEARING ON SECTION 103(d) REGULATIONS § 228.1 Basis and...

  20. 42 CFR 494.1 - Basis and scope.

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Basis and scope. 494.1 Section 494.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS... or adopted by voluntary consensus standards bodies, unless their use would be inconsistent with...