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Sample records for fp worth evaluation

  1. Lazy evaluation of FP programs: A data-flow approach

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Y.H. [International Business Machines Corp., Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Gaudiot, J.L. [University of Southern California, Los Angeles, CA (United States). Computer Research Inst.

    1988-12-31

    This paper presents a lazy evaluation system for the list-based functional language, Backus` FP in data-driven environment. A superset language of FP, called DFP (Demand-driven FP), is introduced. FP eager programs are transformed into DFP lazy programs which contain the notions of demands. The data-driven execution of DFP programs has the same effects of lazy evaluation. DFP lazy programs have the property of always evaluating a sufficient and necessary result. The infinite sequence generator is used to demonstrate the eager-lazy program transformation and the execution of the lazy programs.

  2. The Distinction Between Merit and Worth in Evaluation.

    Science.gov (United States)

    Lincoln, Yvonna S.; Guba, Egon G.

    Valuing in evaluation encompasses two distinct senses of the word, denoted by the terms merit and worth. Merit may be defined as an entity's inherent, intrinsic, context-free value, while an entity's worth is defined as its contextually determined, place-bound value. Determining an entity's merit may take place whenever a number of experts are…

  3. 38 CFR 3.275 - Criteria for evaluating net worth.

    Science.gov (United States)

    2010-07-01

    ... net worth. 3.275 Section 3.275 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Improved Pension Program Which Became Effective January 1, 1979 § 3.275 Criteria for evaluating net worth. (a) General. The following rules are for application in determining the corpus of estate or net...

  4. Computer program system for evaluation of FP nuclear data for JENDL. Smooth part

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    Nakagawa, Tsuneo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Watanabe, Takashi; Iijima, Shungo

    1997-12-01

    This report describes computer programs used to evaluate nuclear data of fission product (FP) nuclides stored in an evaluated nuclear data library JENDL, especially in the smooth part above the resonance region. Many programs were used for determination of nuclear model parameters, calculation of nuclear data, handling of experimental and/or calculated data, and so on. Among them, reported here are programs for determination of level density parameters (ENSDFRET, LVLPLOT, LEVDES), for making sets of JCL and input data for the theoretical calculation program CASTHY (JOBSETTER, INDES/CASTHY), and for conversion of format of CASTHY output files to the ENDF format (CTOB2). (author). 51 refs.

  5. Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons

    Science.gov (United States)

    Lim, Keunpoong; Labaree, David; Ropchan, Jim; Harris, Paul; Huang, Yiyun; Ichise, Masanori; Carson, Richard E.; Cline, Gary W.

    2017-01-01

    Introduction 18F-Fluoropropyl-(+)-dihydrotetrabenazine (18F-FP-(+)-DTBZ) is a vesicular monoamine transporter type 2 (VMAT2) radiotracer for positron emission tomography (PET) imaging to quantify human β-cell mass. Renal cortex and spleen have been suggested as reference regions, however, little is known about 18F-FP-(+)-DTBZ binding in these regions including the fraction of radiometabolite. We compared the kinetics of 18F-FP-(+)-DTBZ and its inactive enantiomer 18F-FP-(−)-DTBZ in baboons, estimated the non-displaceable binding (VND) of the tracers, and used ex vivo studies to measure radiometabolite fractions. Methods PET scans were conducted for up to 4 h with (+) and (−) enantiomers. Displacement experiments using unlabeled (+) and (−) enantiomers of FP-DTBZ and fluvoxamine (to evaluate sigma-1 receptor binding) were performed. SUV curves were used to calculate displacement values in the pancreas, renal cortex, and spleen. Distribution volumes (VT) were computed, and three approaches for calculation of VND were compared: (1) 18F-FP-(+)-DTBZ reference VT, (2) 18F-FP-(−)-DTBZ pancreatic VT, and (3) a scaled 18F-FP-(+)-DTBZ reference VT values. Ex vivo study was conducted to measure radiometabolite fraction in homogenized tissue samples from baboons at 90 min post-injection. Results Spleen uptake was lowest for both tracers. Highest uptake was in the pancreas with 18F-FP-(+)-DTBZ and renal cortex with 18F-FP-(−)-DTBZ. Substantial displacement effect was observed only with unlabeled FP-(+)-DTBZ in the 18F-FP-(+)-DTBZ studies. Radiometabolite fraction was higher in the renal cortex than the spleen. Approaches (1) and (3) with spleen to estimate VND provided lowest inter-subject variability of BPND. Conclusions VT differences among organs and between enantiomers indicated that scaling of reference region values is needed for quantification of VMAT2 binding in the pancreas with 18F-FP-(+)-DTBZ. Since the kidney PET signal has greater partial volume

  6. ISOS: A job evaluation system to implement comparable worth

    Directory of Open Access Journals (Sweden)

    Albert Corominas

    2008-01-01

    Full Text Available A fair pay structure is an essential element of the personnel policy of a firm. If the pay structure is perceived as arbitrary by the members of the staff, it becomes a cause of disturbance of the labor relations. Particularly, a pay structure is unfair if it discriminates against women. Job evaluation is a traditional tool used by companies to assist in the process of determining pay structures that can be also useful to detect and combat wage discrimination, since allow determining whether two jobs are of comparable worth or not. Although there are many kinds of systems, authors agree when defining point factor methods as the most appropriate and fair job evaluation systems. However, even being well defined from a technical point of view, most existing systems give discriminatory results regarding to gender. ISOS, a new job evaluation system which is described in this paper, has been designed, with the aim to define a neutral system with regard to gender, based on present jobs characteristics, existing job evaluation systems and job description questionnaires, international experts’ knowledge and a wide body of literature on gender discrimination and its relation with job evaluation. Using ISOS can contribute to detect, combat and eliminate part of the existing wage discrimination in general and, in particular, against women. ISOS includes all aspects of the work so no characteristics are omitted. The system can be applied in any company and to evaluate any job, and offers flexibility to be adapted to the specific characteristics of an organization. ISOS can also be used to detect and combat wage discrimination. Furthermore, characteristics of present jobs, such as cross-training or flexible working time, are also included so the system can be considered innovative in a very traditional field of industrial engineering.

  7. Evaluating data worth for ground-water management under uncertainty

    Science.gov (United States)

    Wagner, B.J.

    1999-01-01

    A decision framework is presented for assessing the value of ground-water sampling within the context of ground-water management under uncertainty. The framework couples two optimization models-a chance-constrained ground-water management model and an integer-programing sampling network design model-to identify optimal pumping and sampling strategies. The methodology consists of four steps: (1) The optimal ground-water management strategy for the present level of model uncertainty is determined using the chance-constrained management model; (2) for a specified data collection budget, the monitoring network design model identifies, prior to data collection, the sampling strategy that will minimize model uncertainty; (3) the optimal ground-water management strategy is recalculated on the basis of the projected model uncertainty after sampling; and (4) the worth of the monitoring strategy is assessed by comparing the value of the sample information-i.e., the projected reduction in management costs-with the cost of data collection. Steps 2-4 are repeated for a series of data collection budgets, producing a suite of management/monitoring alternatives, from which the best alternative can be selected. A hypothetical example demonstrates the methodology's ability to identify the ground-water sampling strategy with greatest net economic benefit for ground-water management.A decision framework is presented for assessing the value of ground-water sampling within the context of ground-water management under uncertainty. The framework couples two optimization models - a chance-constrained ground-water management model and an integer-programming sampling network design model - to identify optimal pumping and sampling strategies. The methodology consists of four steps: (1) The optimal ground-water management strategy for the present level of model uncertainty is determined using the chance-constrained management model; (2) for a specified data collection budget, the monitoring

  8. [Quantitative evaluation of 123I-FP-CIT SPECT: validation of a semiautomated method].

    Science.gov (United States)

    Lorenzo Bosquet, C; Cuberas Borrós, G; Miquel Rodríguez, F; Caresia, P; Aguadé Bruix, S; Castell Conesa, J

    2005-01-01

    To assess the utility of a quantification of the 123I-FP-CIT uptake by the definition of some reference values, normal range values and interobserver variation. Fifty patients with a 123I-FP-CIT SPECT: 25 patients had a pathological SPECT with the diagnosis of Parkinson's disease and the remaining had a qualitative normal SPET, with the diagnosis of 14 drug-induced Parkinsonism and 11 with psychogenic Parkinsonism. In the transversal slices, the best central slice that showed the nuclei of the base best was selected and standard ROIs (Region Of Interest) were applied. Specific (caudate and putamen) versus non specific (occipital) and laterality ratios were calculated. A normal statistical analysis for independent quantitative samples was used (mean, standard deviation and range) as well as variation coefficient and correlation coefficient of two observers and the 10th and 90th percentile. The variation coefficient interobserver was 3.24-5.61 and the correlation coefficient was 0.89-0.99. Cut-off values between both populations were established at 2.10 in the right putamen and at 2.05 in the left. Cut-off values definition in caudate were not assessable due to overlapping of ratios of both populations. This quantification method is highly reproducible. It makes it possible to obtain reference values and to define normal range.

  9. Evaluation of Multiple System Atrophy and Early Parkinson's Disease Using {sup 123}I-FP-CIT SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Oh, So Won; Kim, Yu Kyeong; Lee, Byung Chul; Kim, Bom Sahn; Kim, Ji Sun; Kim, Jong Min; Kim, Sang Eun [Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of)

    2009-02-15

    We investigated quantification of dopaminergic transporter (DAT) and serotonergic transporter (SERT) on {sup 123}I-FP-CIT SPECT for differentiating between multiple systemic atrophy (MSA) and idiopathic Parkinson's disease (IPD). N.fluoropropyl-2{beta}-carbomethoxy-3{beta}-4-[{sup 123}I]-iodophenylnortropane SPECT ({sup 123}I-FP-CIT SPECT) was performed in 8 patients with MSA (mean age: 64.0{+-}4.5yrs, m:f=6:2), 13 with early IPD (mean age: 65.5{+-}5.3yrs, m:f=9:4), and 12 healthy controls (mean age: 63.3{+-}5.7yrs, m:f=8:4). Standard regions of interests (ROIs) of striatum to evaluate DAT, and hypothalamus and midbrain for SERT were drawn on standard template images and applied to each image taken 4 hours after radiotracer injection. Striatal specific binding for DAT and hypothalamic and midbrain specific binding for SERT were calculated using region/reference ratio based on the transient equilibrium method. Group differences were tested using ANOVA with the postHoc analysis. DAT in the whole striatum and striatal subregions were significantly decreased in both patient groups with MSA and early IPD, compared with healthy control (p<0.05 in all). In early IPD, a significant increase in the uptake ratio in anterior and posterior putamen and a trend of increase in caudate to putamen ratio was observed. In MSA, the decrease of DAT was accompanied with no difference in the striatal uptake pattern compared with healthy controls. Regarding the brain regions where {sup 123}I-FP-CIT binding was predominant by SERT, MSA patients showed a decrease in the binding of {sup 123}I-FP-CIT in the pons compared with controls as well as early IPD patients (MSA: 0.22{+-}0.1 healthy controls: 0.33{+-}0.19, IPD: 0.29{+-}0.19), however, it did not reach the statistical significance. In this study, the differential patterns in the reduction of DAT in the striatum and the reduction of pontine {sup 123}I- FP-CIT binding predominant by SERT could be observed in MSA patients on {sup 123

  10. Cyclic Codes over Fp + uFp + vFp + uvFp%环Fp+uFp+vFp+uvFp上的循环码

    Institute of Scientific and Technical Information of China (English)

    许小芳; 刘修生

    2013-01-01

    In this paper,cyclic codes over the ring R =Fp + uFp + vFp + uvFp arediscussed,where the ring R is not afinite chain ring.By studying the polynomial ring Rn =(Fp + uFp + vFp + uvFp,) [x]/(xn-1) and using the corresponding relationship between the cyclic codes over the ring R and the ideals in the ringRn,cyclic codes over the ring R are characterized.Finally,a Gray-map is obtained and the images of cyclic codes over the ring R are characterized.%讨论了非有限链环R=Fp+uFp+vFp+uvFp上的循环码.通过环R上的循环码与多项式环Rn=(Fp+uFp+vFp+uvFp)[x]/(xn-1)的理想的对应关系及对Rn的研究给出了R上循环码的刻画.最后定义了一个Gray映射,并刻画了Fp+uFp+vFp+uvFp上的循环码在该映射下的像.

  11. Evaluating the Latent Structure of the MMPI-2 F(p) Scale in a Forensic Sample: A Taxometric Analysis

    Science.gov (United States)

    Strong, David R.; Glassmire, David M.; Frederick, Richard I.; Greene, Roger L.

    2006-01-01

    P. A. Arbisi and Y. S. Ben-Porath (1995) originally proposed that the Infrequency Psychopathology scale, F(p), be used as the final step in an algorithm to determine the validity of a Minnesota Multiphasic Personality Inventory-2 (MMPI-2) protocol. The current study used taxometric procedures to determine the latent structure of F(p) among…

  12. Benchmark Evaluation of the HTR-PROTEUS Absorber Rod Worths (Core 4)

    Energy Technology Data Exchange (ETDEWEB)

    John D. Bess; Leland M. Montierth

    2014-06-01

    PROTEUS was a zero-power research reactor at the Paul Scherrer Institute (PSI) in Switzerland. The critical assembly was constructed from a large graphite annulus surrounding a central cylindrical cavity. Various experimental programs were investigated in PROTEUS; during the years 1992 through 1996, it was configured as a pebble-bed reactor and designated HTR-PROTEUS. Various critical configurations were assembled with each accompanied by an assortment of reactor physics experiments including differential and integral absorber rod measurements, kinetics, reaction rate distributions, water ingress effects, and small sample reactivity effects [1]. Four benchmark reports were previously prepared and included in the March 2013 edition of the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook) [2] evaluating eleven critical configurations. A summary of that effort was previously provided [3] and an analysis of absorber rod worth measurements for Cores 9 and 10 have been performed prior to this analysis and included in PROTEUS-GCR-EXP-004 [4]. In the current benchmark effort, absorber rod worths measured for Core Configuration 4, which was the only core with a randomly-packed pebble loading, have been evaluated for inclusion as a revision to the HTR-PROTEUS benchmark report PROTEUS-GCR-EXP-002.

  13. Benchmark Evaluation of Fuel Effect and Material Worth Measurements for a Beryllium-Reflected Space Reactor Mockup

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, Margaret A. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Center for Space Nuclear Research; Bess, John D. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-02-01

    The critical configuration of the small, compact critical assembly (SCCA) experiments performed at the Oak Ridge Critical Experiments Facility (ORCEF) in 1962-1965 have been evaluated as acceptable benchmark experiments for inclusion in the International Handbook of Evaluated Criticality Safety Benchmark Experiments. The initial intent of these experiments was to support the design of the Medium Power Reactor Experiment (MPRE) program, whose purpose was to study “power plants for the production of electrical power in space vehicles.” The third configuration in this series of experiments was a beryllium-reflected assembly of stainless-steel-clad, highly enriched uranium (HEU)-O2 fuel mockup of a potassium-cooled space power reactor. Reactivity measurements cadmium ratio spectral measurements and fission rate measurements were measured through the core and top reflector. Fuel effect worth measurements and neutron moderating and absorbing material worths were also measured in the assembly fuel region. The cadmium ratios, fission rate, and worth measurements were evaluated for inclusion in the International Handbook of Evaluated Criticality Safety Benchmark Experiments. The fuel tube effect and neutron moderating and absorbing material worth measurements are the focus of this paper. Additionally, a measurement of the worth of potassium filling the core region was performed but has not yet been evaluated Pellets of 93.15 wt.% enriched uranium dioxide (UO2) were stacked in 30.48 cm tall stainless steel fuel tubes (0.3 cm tall end caps). Each fuel tube had 26 pellets with a total mass of 295.8 g UO2 per tube. 253 tubes were arranged in 1.506-cm triangular lattice. An additional 7-tube cluster critical configuration was also measured but not used for any physics measurements. The core was surrounded on all side by a beryllium reflector. The fuel effect worths were measured by removing fuel tubes at various radius. An accident scenario

  14. Fp+uFp+vFp+uvFp上的线性码%Linear Codes Over Fp+uFp+vFp+uvFp

    Institute of Scientific and Technical Information of China (English)

    许小芳

    2013-01-01

    The linear codes over the ring R=Fp+uFp+vFp+uυFp are discussed,where the ring R is not a finite chain ring.The structure of the ring R is analyzed and linear codes over this ring are defined,and the linear code of type (p4)k1 (p3)k2 (u)k3 (v)k4 (u+υ)k5 (p)k6 is characterized.%讨论了有限非链环R=Fp+uFpFp+uυFp上的线性码,分析了环R的结构,给出了此环上线性码的定义,并讨论了环R上(p4)k1 (p3)k2 (u)b(u)k4(u+υ)k5(p)k6型的线性码.

  15. Evaluation of fission product worth margins in PWR spent nuclear fuel burnup credit calculations.

    Energy Technology Data Exchange (ETDEWEB)

    Blomquist, R.N.; Finck, P.J.; Jammes, C.; Stenberg, C.G.

    1999-02-17

    Current criticality safety calculations for the transportation of irradiated LWR fuel make the very conservative assumption that the fuel is fresh. This results in a very substantial overprediction of the actual k{sub eff} of the transportation casks; in certain cases, this decreases the amount of spent fuel which can be loaded in a cask, and increases the cost of transporting the spent fuel to the repository. Accounting for the change of reactivity due to fuel depletion is usually referred to as ''burnup credit.'' The US DOE is currently funding a program aimed at establishing an actinide only burnup credit methodology (in this case, the calculated reactivity takes into account the buildup or depletion of a limited number of actinides). This work is undergoing NRC review. While this methodology is being validated on a significant experimental basis, it implicitly relies on additional margins: in particular, the absorption of neutrons by certain actinides and by all fission products is not taken into account. This provides an important additional margin and helps guarantee that the methodology is conservative provided these neglected absorption are known with reasonable accuracy. This report establishes the accuracy of fission product absorption rate calculations: (1) the analysis of European fission product worth experiments demonstrates that fission product cross-sections available in the US provide very good predictions of fission product worth; (2) this is confirmed by a direct comparison of European and US cross section evaluations; (3) accuracy of Spent Nuclear Fuel (SNF) fission product content predictions is established in a recent ORNL report where several SNF isotopic assays are analyzed; and (4) these data are then combined to establish in a conservative manner the fraction of the predicted total fission product absorption which can be guaranteed based on available experimental data.

  16. Bibliometric performance analysis of publications from Danish researchers linked to FP6 and FP7

    DEFF Research Database (Denmark)

    Schneider, Jesper Wiborg; Ryan, Thomas Kjeldager

    2015-01-01

    This chapter presents an analysis29 of the impact of Danish scientific publications that were the result of FP6 or FP7 funding. The purpose is to gain an insight into the scientific impact researchers can achieve when participating in FP6 and FP7. In order to look at impact we have identified...... citations belonging to scientific publications with at least one Danish author. This is done using data from the international citation database Web of Science (WoS). These results are compared to the results of the bibliometric analyses from the previous evaluations of the Danish National Research...

  17. [Comparative evaluation of speech disorders and verbal and non verbal communication within two groups of patients: patients with facial paralysis (FP) and those who had undergone hypoglosso-facial anastomosis (HFA)].

    Science.gov (United States)

    Gatignol, P; Tankere, F; Clero, D; Lobryau, Ch; Soudant, J; Lamas, G

    2003-01-01

    Speech disorders were often allotted to hypoglossal-facial anastomosis (HFA) without being clearly shown. We have compared patients with a peripheral facial paralysis at those with HFA. Retrospective study comparing verbal communication (articulation) and non-verbal within two groups of patients: patients with patient FP versus with HFA. 10 patients with idiopathic FP versus 7 patients with HFA took part in this study. The series of tests includes an evaluation of the motor possibilities, bilabial pressure measurement (for the patients with FP), speech capacities and finally an evaluation of the verbal and non-verbal communication from a scale of satisfaction. The results highlight: the presence of real speech disorders (permanent) among patients with FP and their absence among patients having profited from HFA; a real satisfaction of the HFA versus FP on the quality of life compared to daily tasks, more specifically concerning verbal and food skills. The HFA is not responsible for speech disorders, and makes undeniable improvements confirmed subsequently by the patients.

  18. Development of a digital reactivity meter for criticality prediction and control rod worth evaluation in pressurized water reactors

    Energy Technology Data Exchange (ETDEWEB)

    Kuramoto, Renato Y.R.; Miranda, Anselmo F.; Valladares, Gastao Lommez; Prado, Adelk C. [Eletrobras Termonuclear S.A. - ELETRONUCLEAR, Angra dos Reis, RJ (Brazil). Central Nuclear Almirante Alvaro Alberto], e-mail: kuramot@eletronuclear.gov.br

    2009-07-01

    In this work, we have proposed the development of a digital reactivity meter in order to monitor subcriticality continuously during criticality approach in a PWR. A subcritical reactivity meter can provide an easy prediction of the estimated critical point prior to reactor criticality, without complicated hand calculation. Moreover, in order to reduce the interval of the Physics Tests from the economical point of view, a subcritical reactivity meter can evaluate the control rod worth from direct subcriticality measurement. In other words, count rate of Source Range (SR) detector recorded during the criticality approach could be used for subcriticality evaluation or control rod worth evaluation. Basically, a digital reactivity meter is based on the inverse solution of the kinetic equations of a reactor with the external neutron source in one-point reactor model. There are some difficulties in the direct application of a digital reactivity meter to the subcriticality measurement. When the Inverse Kinetic method is applied to a sufficiently high power level or to a core without an external neutron source, the neutron source term may be neglected. When applied to a lower power level or in the sub-critical domain, however, the source effects must be taken in account. Furthermore, some treatments are needed in using the count rate of Source Range (SR) detector as input signal to the digital reactivity meter. To overcome these difficulties, we have proposed a digital reactivity meter combined with a methodology of the modified Neutron Source Multiplication (NSM) method with correction factors for subcriticality measurements in PWR. (author)

  19. Investigation of Bias in Job Evaluation Ratings of Comparable Worth Study Participants.

    Science.gov (United States)

    Mount, Michael K.; Ellis, Rebecca A.

    1987-01-01

    Investigated the effects of knowledge of current pay levels and perceived job gender on subsequent job evaluations. Confirmed the hypothesis that jobs with high pay levels would receive higher evaluations than jobs with low pay levels. Found evidence of a pro-female bias in the job evaluation ratings of 53 job evaluators. (Author/ABB)

  20. [Clinical evaluations of neoadjuvant chemotherapy with DN and FP regimens for patients with middle or lower thoracic locally advanced esophageal squamous cell carcinoma].

    Science.gov (United States)

    Yang, Hongxia; Yao, Juan; Wen, Hong; Yu, Lan; Liu, Wu; Liang, Hua; Han, Shuhong

    2015-05-19

    To explore the efficacies and side effects of neoadjuvant chemotherapy with DN (docetaxel plus cisplatin) and FP (nedaplatin plus cisplatin) regimens for patients with upper or middle thoracic locally advanced esophageal squamous cell carcinoma. From January 2008 to January 2012, a total of 124 patients with upper or middle thoracic locally advanced esophageal squamous cell carcinoma were randomized into DN group (n = 64) and FP group (n = 60). Both groups received neoadjuvant chemotherapy. The treatment schedule was recycled every 3 weeks. After 2 cycles, those with potential surgical resection underwent surgery. The 2-year overall, locoregional relapse-free and distant metastasis-free survival rates in DN and FP groups were 71.1% and 66.7%, 65.0% and 63.0%, 78.3% and 74.3% respectively (P > 0.05). The incidence of leucopenia was higher in DN group than that in FP group (P DN group. No perioperative mortality occurred with a low incidence of postoperative complications. The rates of overall response, resection, postoperative complications and pathological complete rates response were similar in two groups. And the rates of downstage and R0 resection were significantly higher in DN group than those in FP group (P < 0.05). For patients with middle or lower thoracic locally advanced esophageal squamous cell carcinoma, neoadjuvant chemotherapies of docetaxel and nedaplatin may achieve excellent outcomes in clinical response and 2-year survival rate. And the side effects are clinically acceptable.

  1. Evaluating item endorsement rates for the MMPI-2-RF F-r and Fp-r scales across ethnic, gender, and diagnostic groups with a forensic inpatient sample.

    Science.gov (United States)

    Glassmire, David M; Jhawar, Amandeep; Burchett, Danielle; Tarescavage, Anthony M

    2017-05-01

    The Minnesota Multiphasic Personality Inventory-2 (MMPI-2) F(p) (Infrequency-Psychopathology) scale was developed to measure overreporting in a manner that was minimally confounded by genuine psychopathology, which was a problem with using the MMPI-2 F (Infrequency) scale among patients with severe mental illness. Although revised versions of both of these scales are included on the MMPI-2-Restructured Form and used in a forensic context, no item-level research has been conducted on their sensitivity to genuine psychopathology among forensic psychiatric inpatients. Therefore, we examined the psychometric properties of the scales in a sample of 438 criminally committed forensic psychiatric inpatients who were adjudicated as not guilty by reason of insanity and had no known incentive to overreport. We found that 20 of the 21 Fp-r items (95.2%) demonstrated endorsement rates ≤ 20%, with 14 of the items (66.7%) endorsed by less than 10% of the sample. Similar findings were observed across genders and across patients with mood and psychotic disorders. The one item endorsed by more than 20% of the sample had a 23.7% overall endorsement rate and significantly different endorsement rates across ethnic groups, with the highest endorsements occurring among Hispanic/Latino (43.3% endorsement rate) patients. Endorsement rates of F-r items were generally higher than for Fp-r items. At the scale level, we also examined correlations with the Restructured Clinical Scales and found that Fp-r demonstrated lower correlations than F-r, indicating that Fp-r is less associated with a broad range of psychopathology. Finally, we found that Fp-r demonstrated slightly higher specificity values than F-r at all T score cutoffs. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  2. [Is rehabilitation worth it? : Review of economic evaluations of rehabilitation in Germany].

    Science.gov (United States)

    Krauth, Christian; Bartling, Tim

    2017-04-01

    Because of demographic change, the rehabilitation sector in Germany is going to face increasing demands in the future. Limited budgets make the optimal allocation of resources a top priority. To support decisions about the optimal scope and design of rehabilitation, studies on health economics are of utmost importance. The aim of this article is to provide an overview of the evaluation of rehabilitation with regard to health economics in Germany.Based on a comprehensive literature research, 17 studies on the cost-effectiveness of rehabilitation in Germany were identified. The health economics evaluation focuses on four main topics: patient education (5 studies), the comparison of outpatient and inpatient rehabilitation (7 studies), medico-occupational rehabilitation programs (2 studies) and aftercare programs (3 studies). All four topics show that innovative rehabilitation technologies can be cost-effective. Significant potential savings in program costs of 25-35% are demonstrated in outpatient rehabilitation (with comparable effectiveness with inpatient care). Designated patient education programs often lead to significant savings with indirect costs, by reducing periods of unfitness to work and extending the long-term ability to work. This review article also points out that some relevant areas of rehabilitation, such as the flexibilization of rehabilitation programs or the efficient organization of access to rehabilitation, have not been evaluated sufficiently on the basis of health economics. This article ends with the requirement to carry out more economics-based rehabilitation studies.

  3. How much is new information worth? Evaluating the financial benefit of resolving management uncertainty

    Science.gov (United States)

    Maxwell, Sean L.; Rhodes, Jonathan R.; Runge, Michael C.; Possingham, Hugh P.; Ng, Chooi Fei; McDonald Madden, Eve

    2015-01-01

    Conservation decision-makers face a trade-off between spending limited funds on direct management action, or gaining new information in an attempt to improve management performance in the future. Value-of-information analysis can help to resolve this trade-off by evaluating how much management performance could improve if new information was gained. Value-of-information analysis has been used extensively in other disciplines, but there are only a few examples where it has informed conservation planning, none of which have used it to evaluate the financial value of gaining new information. We address this gap by applying value-of-information analysis to the management of a declining koala Phascolarctos cinereuspopulation. Decision-makers responsible for managing this population face uncertainty about survival and fecundity rates, and how habitat cover affects mortality threats. The value of gaining new information about these uncertainties was calculated using a deterministic matrix model of the koala population to find the expected population growth rate if koala mortality threats were optimally managed under alternative model hypotheses, which represented the uncertainties faced by koala managers. Gaining new information about survival and fecundity rates and the effect of habitat cover on mortality threats will do little to improve koala management. Across a range of management budgets, no more than 1·7% of the budget should be spent on resolving these uncertainties. The value of information was low because optimal management decisions were not sensitive to the uncertainties we considered. Decisions were instead driven by a substantial difference in the cost efficiency of management actions. The value of information was up to forty times higher when the cost efficiencies of different koala management actions were similar. Synthesis and applications. This study evaluates the ecological and financial benefits of gaining new information to inform a conservation

  4. Reliability and cost/worth evaluation of generating systems utilizing wind and solar energy

    Science.gov (United States)

    Bagen

    The utilization of renewable energy resources such as wind and solar energy for electric power supply has received considerable attention in recent years due to adverse environmental impacts and fuel cost escalation associated with conventional generation. At the present time, wind and/or solar energy sources are utilized to generate electric power in many applications. Wind and solar energy will become important sources for power generation in the future because of their environmental, social and economic benefits, together with public support and government incentives. The wind and sunlight are, however, unstable and variable energy sources, and behave far differently than conventional sources. Energy storage systems are, therefore, often required to smooth the fluctuating nature of the energy conversion system especially in small isolated applications. The research work presented in this thesis is focused on the development and application of reliability and economic benefits assessment associated with incorporating wind energy, solar energy and energy storage in power generating systems. A probabilistic approach using sequential Monte Carlo simulation was employed in this research and a number of analyses were conducted with regards to the adequacy and economic assessment of generation systems containing wind energy, solar energy and energy storage. The evaluation models and techniques incorporate risk index distributions and different operating strategies associated with diesel generation in small isolated systems. Deterministic and probabilistic techniques are combined in this thesis using a system well-being approach to provide useful adequacy indices for small isolated systems that include renewable energy and energy storage. The concepts presented and examples illustrated in this thesis will help power system planners and utility managers to assess the reliability and economic benefits of utilizing wind energy conversion systems, solar energy conversion

  5. Improved visual [(123)I]FP-CIT SPECT interpretation for evaluation of parkinsonism by visual rating of parametric distribution volume ratio images.

    Science.gov (United States)

    Meyer, P T; Winz, O H; Dafotakis, M; Werner, C J; Krohn, T; Schäfer, W M

    2011-06-01

    Imaging of presynaptic dopamine transporters (DAT) by single-photon emission computed tomography (SPECT) and [(123)I]FP-CIT is an established method for differentiating between neurodegenerative and non-neurodegenerative parkinsonism. Whereas a region-of-interest (ROI) analysis is the method of choice for analyzing [(123)I]FP-CIT SPECT studies, visual image interpretations can also provide highly accurate results. The present study was undertaken to validate a visual reading system for parametric volume of distribution (DVR) [(123)I]FP-CIT SPECT images that combines the quantitative nature of ROI analyses and the simplicity of visual readings. A 9-step linear visual rating template for semi-quantitative DVR ratings of caudate nucleus and putamen was developed (VRDVR). The conventional 4-step visual reading system that is mainly based on the [(123)I]FP-CIT uptake pattern was used for comparison (VRP method). Six independent observers retrospectively rated the [(123)I]FP-CIT scans of 30 consecutive parkinsonism and tremor patients (N.=16 neurodegenerative, N.=14 non-neurodegenerative) using VRDVR and VRP. In addition, a highly trained investigator performed manual ROI analyses. The ROI analysis provided complete separation of both patient groups by comparing the lower DAT binding of both putamina (i.e., putamen contralateral to clinically most affected side in neurodegenerative parkinsonism). Using VRP, the two most experienced observers correctly classified all patients while 20 false-positive ratings occurred in the less experienced observers (mean area under the receiver operating characteristic curve [AUCROC] of all observers 0.93±0.07). The VRDVR ratings of the two most experienced observers did not overlap between patient groups, although at different VRDVR score cut-offs. Using the same VRDVR score cut-off for all observers, only six false-negative and one false-positive ratings occurred in total (AUCROC 0.99±0.01). Inter-observer agreement was good for VRP

  6. FUNCTIONAL CORRELATION OF FP AND DC METHODS

    Directory of Open Access Journals (Sweden)

    Marin Kaluža

    2013-02-01

    Full Text Available Most of organizations today use information-communication technologies (ICT for building an information system (IS. IS is assembled of hardware, software, network resources, organizational and human resources. In IS development process, complexity is crucial for evaluating quantities of resources needed (time, people, money, equipment. Complexity of an IS can be evaluated and/or measured in different phases of development. There are many methods for measuring complexity, but mostly used and thoroughly described method is Function Point Analysis (FP. The opposite method, Database Complexity (DC, does not measure all the aspects of IS, but it could evaluate system complexity depending on the database complexity. DC method is intended to be used for measuring semantic complexity of the IS database, and can be shown by counting attributes A and foreign keys F. This paper describes a very high correlation between FP and DC methods, and defines a function which can in 95% of accuracy express FP values from measured DC values.

  7. JENDL FP decay data file 2000

    Energy Technology Data Exchange (ETDEWEB)

    Katakura, Jun-ichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Yoshida, Tadashi [Musashi Inst. of Tech., Tokyo (Japan); Oyamatsu, Kazuhiro [Aichi Shukutoku Univ., Nagakute, Aichi (Japan); Tachibana, Takahiro [Waseda Univ., Tokyo (Japan)

    2001-07-01

    A decay data file of fission product (FP) nuclides has been developed for the use in nuclear technology field as one of special purpose files of JENDL (Japanese Evaluated Nuclear Data Library) in the format of ENDF/B and it is called JENDL FP Decay Data File 2000. The file includes the decay data for 1229 fission product nuclides: 142 stable and 1087 unstable nuclides. The data included for a nuclide are decay modes, their Q values and branching ratios, average decay energy values of beta-rays, gamma-rays and alpha-particles and their spectral data. The primary source of the decay data is ENSDF (Evaluated Nuclear Structure Data File), which is the internationally recognized data file of nuclear structure properties. The data in ENSDF, however, cover only measured ones. The data of the short-lived nuclides needed for the application fields such as decay heat prediction are often incomplete or not measured because of their short half-lives. For such nuclides a theoretical model calculation is applied to derive the needed data such as average decay energies and spectral data. The data in JENDL FP Decay Data File 2000 have been tested by summation calculation comparing its results with measured data of decay heat values and aggregate fission product spectra of various fissioning nuclei. The comparison showed good agreement between the calculated results and the measured values. (author)

  8. European multicentre database of healthy controls for [{sup 123}I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis

    Energy Technology Data Exchange (ETDEWEB)

    Varrone, Andrea [Karolinska University Hospital, R5:02, Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm (Sweden); Dickson, John C. [UCLH NHS Foundation Trust and University College, Institute of Nuclear Medicine, London (United Kingdom); Tossici-Bolt, Livia [University Hospitals Southampton NHS Trust, Department of Medical Physics, Southampton (United Kingdom); Sera, Terez [University of Szeged, Department of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Asenbaum, Susanne [Medical University of Vienna, Department of Nuclear Medicine, Vienna (Austria); Booij, Jan [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Centre, Amsterdam (Netherlands); Kapucu, Ozlem L. [Gazi University, Department of Nuclear Medicine, Faculty of Medicine, Ankara (Turkey); Kluge, Andreas [ABX-CRO, Dresden (Germany); Knudsen, Gitte M. [Rigshospitalet and University of Copenhagen, Neurobiology Research Unit, Copenhagen (Denmark); Koulibaly, Pierre Malick [University of Nice-Sophia Antipolis, Nuclear Medicine Department, Centre Antoine Lacassagne, Nice (France); Nobili, Flavio [University of Genoa, Clinical Neurophysiology Unit, Department of Neuroscience, Ophthalmology and Genetics, Genoa (Italy); Pagani, Marco [Institute of Cognitive Sciences and Technologies, CNR, Rome (Italy); Karolinska University Hospital, Department of Nuclear Medicine, Stockholm (Sweden); Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Borght, Thierry vander [Universite Catholique de Louvain, Nuclear Medicine Division, Mont-Godinne Medical Center, Yvoir (Belgium); Laere, Koen van [University Hospital and K.U. Leuven, Nuclear Medicine, Leuven (Belgium); Tatsch, Klaus [Municipal Hospital of Karlsruhe Inc, Department of Nuclear Medicine, Karlsruhe (Germany)

    2013-02-15

    Dopamine transporter (DAT) imaging with [{sup 123}I]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [{sup 123}I]FP-CIT SPECT scans in healthy controls. SPECT data from 139 healthy controls (74 men, 65 women; age range 20 - 83 years, mean 53 years) acquired in 13 different centres were included. Images were reconstructed using the ordered-subset expectation-maximization algorithm without correction (NOACSC), with attenuation correction (AC), and with both attenuation and scatter correction using the triple-energy window method (ACSC). Region-of-interest analysis was performed using the BRASS software (caudate and putamen), and the Southampton method (striatum). The outcome measure was the specific binding ratio (SBR). A significant effect of age on SBR was found for all data. Gender had a significant effect on SBR in the caudate and putamen for the NOACSC and AC data, and only in the left caudate for the ACSC data (BRASS method). Significant effects of age and gender on striatal SBR were observed for all data analysed with the Southampton method. Overall, there was a significant age-related decline in SBR of between 4 % and 6.7 % per decade. This study provides a large database of [{sup 123}I]FP-CIT SPECT scans in healthy controls across a wide age range and with balanced gender representation. Higher DAT availability was found in women than in men. An average age-related decline in DAT availability of 5.5 % per decade was found for both genders, in agreement with previous reports. The data collected in this study may serve as a reference

  9. FP-soft Boolean Algebra%FP-软布尔代数

    Institute of Scientific and Technical Information of China (English)

    刘卫锋; 许宏伟; 何霞

    2015-01-01

    FP-软集(Fuzzy Parameterized Soft Sets)与布尔代数相结合,定义了FP-软布尔代数、FP-软布尔子代数、FP-软布尔代数的FP-软理想、FP-理想软布尔代数等概念,研究了它们的相关性质.最后,讨论了FP-软布尔代数的同态.

  10. Computer Security: Well fought, FP!

    CERN Multimedia

    Stefan Lueders, Computer Security Team

    2015-01-01

    We are used to spam and phishing emails. But at the end of last year, a very special email struck one of our colleagues in the FP Department.   An accountant was gently asked in an email from “Rolf.Heuer@cern.ch” to prepare a financial transaction - in the strictest confidence. A phone call from the beneficiary to the accountant was made in an attempt to support this request. Despite being instructed not to talk to anyone, the e-mail, the phone conversation and the circumstances were all so suspicious that our colleague consulted his hierarchy, the internal audit service and us. Well done, FP Department! This is a rare case of an attempt at “social engineering”, i.e. luring someone into doing something detrimental to the Organization. The e-mail was fake. While it appeared to come from “Rolf.Heuer@cern.ch”, it actually came from an alleged fraudster outside CERN. The e-mail and the phone call showed that he was well prepared and dire...

  11. Supporting Worth Mapping with Sentence Completion

    Science.gov (United States)

    Cockton, Gilbert; Kujala, Sari; Nurkka, Piia; Hölttä, Taneli

    Expectations for design and evaluation approaches are set by the development practices within which they are used. Worth-Centred Development (WCD) seeks to both shape and fit such practices. We report a study that combined two WCD approaches. Sentence completion gathered credible quantitative data on user values, which were used to identify relevant values and aversions of two player groups for an on-line gambling site. These values provided human value elements for a complementary WCD approach of worth mapping. Initial worth maps were extended in three workshops, which focused on outcomes and user experiences that could be better addressed in the current product and associated marketing materials. We describe how worth maps were prepared for, and presented in, workshops, and how product owners and associated business roles evaluated the combination of WCD approaches. Based on our experiences, we offer practical advice on this combinination.

  12. "Is College Worth It?"

    Science.gov (United States)

    Adam, Michelle

    2012-01-01

    The Pew Research Center asked an important question earlier this year when it embarked on an ambitious project called Is College Worth It?: College Presidents, Public Assess Value, Quality and Mission of Higher Education. While most today believe that getting a good education is key to success in the society, this report revealed surprising issues…

  13. How Much Are Harry Potter's Glasses Worth? Children's Monetary Evaluation of Authentic Objects

    Science.gov (United States)

    Gelman, Susan A.; Frazier, Brandy N.; Noles, Nicholaus S.; Manczak, Erika M.; Stilwell, Sarah M.

    2015-01-01

    Adults attach special value to objects that link to notable people or events--authentic objects. We examined children's monetary evaluation of authentic objects, focusing on four kinds: celebrity possessions (e.g., Harry Potter's glasses), original creations (e.g., the very first teddy bear), personal possessions (e.g., your…

  14. How Much Are Harry Potter's Glasses Worth? Children's Monetary Evaluation of Authentic Objects

    Science.gov (United States)

    Gelman, Susan A.; Frazier, Brandy N.; Noles, Nicholaus S.; Manczak, Erika M.; Stilwell, Sarah M.

    2015-01-01

    Adults attach special value to objects that link to notable people or events--authentic objects. We examined children's monetary evaluation of authentic objects, focusing on four kinds: celebrity possessions (e.g., Harry Potter's glasses), original creations (e.g., the very first teddy bear), personal possessions (e.g., your…

  15. Effects of agricultural management on productivity, soil quality and climate change mitigation - evaluations within the EU Project (FP 7) CATCH-C

    Science.gov (United States)

    Spiegel, Heide; Schlatter, Norman; Haslmayr, Hans-Peter; Baumgarten, Andreas; ten Berge, Hein

    2014-05-01

    Soils are the main basis for the production of food and feed. Furthermore, the production of biomass for energy and material use is becoming increasingly important. Goals for an optimal management of agricultural soils are, on the one hand, the maintenance or improvement of soil quality and, on the other hand, high productivity and climate change mitigation (reduction of GHG emissions and C sequestration). Thus, the EU project CATCH-C aims to evaluate current management practices concerning these three goals based on indicators derived from long-term field experiments of the project partners and from literature data. A maximum of 72 indicators for productivity, soil quality and the potential for carbon storage in the soil and the reduction of greenhouse gas emissions were selected by the project partners. As indicators for productivity, crop yields are determined in almost all field trials. The content of soil organic carbon (SOC) is an indicator for chemical, physical and biological soil quality and was analysed in the topsoil in all field trials. Less data exist for SOC contents in the subsoil. An important physical soil quality indicator is the bulk density, however, it is not determined in all field trials of the project partners. Therefore, information on SOC stocks, with relevance to carbon storage and climate change mitigation, is not available in all field experiments. Other physical indicators, such as penetration resistance, runoff coefficient and soil losses are evaluated. Essential biological indicators are microbial biomass and the number and weight of earthworms, which have been tested in several field trials. The evaluation of all these indicators will help to select "best management practices" and to address trade-offs and synergies for all indicators under consideration of major European farm type zones. CATCH-C is funded within the 7th Framework Programme for Research, Technological Development and Demonstration, Theme 2 - Biotechnologies

  16. Design of Production Test IP-262-A-11-FP -- Evaluation of projection fuel elements for use in ribbed process tubes -- Demonstration loading

    Energy Technology Data Exchange (ETDEWEB)

    Hodgson, W.H.; Hall, R.E.

    1959-06-29

    For several years, a major category of fuel element failures has been the side corrosion type, characterized by localized accelerated fuel element jacket corrosion. Since it has been demonstrated {sup 1} that misalignment of fuel elements in a process tube will produce flow patterns and accelerated corrosion, termed ``hot spots``, failure to align the fuel elements in process tubes is considered a contributing factor in the production of side corrosion failures. Preliminary testing of both self-supporting and ``bumper`` fuel elements is underway. Data on the self-supporting fuel elements have demonstrated that the bridge-rail projections have sufficient support strength, do not of themselves create a corrosion problem and in actuality probably eliminate any hot-spot areas. Although one tube of bumper fuel elements in KW Reactor {sup 3} has been discharged, data are not as yet available. Potentially, the most sever corrosion conditions exist during the summer months when reactor inlet temperatures are high. It is desirable then, provided bumper fuel elements limit hot- spot corrosion, to evaluate the bumper concept for large scale use possibly by the summer of 1960. To accomplish this, a demonstration loading of the bumper type fuel elements must be underway by about July, 1959. The purpose of this report is to present the design of a test to evaluate the fabrication process and irradiation performance of fuel elements having projections, which may prevent misalignment in ribbed process tubes and meet the aforementioned goals.

  17. Usability Evaluation of Spot and Runway Departure Advisor (SARDA) Concept in Dallas/Fort Worth Airport Tower Simulation

    Science.gov (United States)

    Hayashi, Miwa; Hoang, Ty; Jung, Yoon C.; Gupta, Gautam; Malik, Waqar; Dulchinos, Victoria

    2013-01-01

    Spot and Runway Departure Advisor (SARDA) is a proposed decision-support tool for air traffic control tower controllers for reducing taxi delay and optimizing the departure sequence. In the present study, the tool's usability was evaluated to ensure that its claimed performance benefits are not being realized at the cost of increasing the work burden on controllers. For the evaluation, workload ratings and questionnaire responses collected during a human-in-the-loop simulation experiment were analyzed to assess the SARDA advisories' effects on the controllers' ratings on cognitive resources (e.g., workload, spare attention) and satisfaction. The results showed that SARDA reduced the controllers' workload and increased their spare attention. It also made workload and attention levels less susceptible to the effects of increases in the traffic load. The questionnaire responses suggested that the controllers generally were satisfied with the ease of use of the tool and the objectives of the SARDA concept, but with some caution. To gain more trust from controllers, the the reasoning behind advisories may need to be made more transparent to them.

  18. Ultrasound and clinical evaluation of soft-tissue versus hardware biceps tenodesis: is hardware tenodesis worth the cost?

    Science.gov (United States)

    Elkousy, Hussein; Romero, Jose A; Edwards, T Bradley; Gartsman, Gary M; O'Connor, Daniel P

    2014-02-01

    This study assesses the failure rate of soft-tissue versus hardware fixation of biceps tenodesis by ultrasound to determine if the expense of a hardware tenodesis technique is warranted. Seventy-two patients that underwent arthroscopic biceps tenodesis over a 3-year period were evaluated using postoperative ultrasonography and clinical examination. The tenodesis technique employed was either a soft-tissue technique with sutures or an interference screw technique using hardware based on surgeon preference. Patient age was 57.9 years on average with ultrasound and clinical examination done at an average of 9.3 months postoperatively. Thirty-one patients had a hardware technique and 41 a soft-tissue technique. Overall, 67.7% of biceps tenodesis done with hardware were intact, compared with 75.6% for the soft-tissue technique by ultrasound (P = .46). Clinical evaluation indicated that 80.7% of hardware techniques and 78% of soft-tissue techniques were intact. Average material cost to the hospital for the hardware technique was $514.32, compared with $32.05 for the soft-tissue technique. Biceps tenodesis success, as determined by clinical deformity and ultrasound, was not improved using hardware as compared to soft-tissue techniques. Soft-tissue techniques are equally efficacious and more cost effective than hardware techniques.

  19. How much are Harry Potter’s glasses worth? Children’s monetary evaluation of authentic objects

    Science.gov (United States)

    Gelman, Susan A.; Frazier, Brandy N.; Noles, Nicholaus S.; Manczak, Erika M.; Stilwell, Sarah M.

    2014-01-01

    Adults attach special value to objects that link to notable people or events – authentic objects. We examined children’s monetary evaluation of authentic objects, focusing on four kinds: celebrity possessions (e.g., Harry Potter’s glasses), original creations (e.g., the very first teddy bear), personal possessions (e.g., your grandfather’s baseball glove), and merely old items (e.g., an old chair). Children ages 4–12 years and adults (N= 151) were asked how much people would pay for authentic and control objects. Young children consistently placed greater monetary value on celebrity possessions than original creations, even when adults judged the two kinds of items to be equivalent. These results suggest that contact with a special individual may be the foundation for the value placed on authentic objects. PMID:25663829

  20. The worth of land use: a GIS-emergy evaluation of natural and human-made capital.

    Science.gov (United States)

    Mellino, Salvatore; Buonocore, Elvira; Ulgiati, Sergio

    2015-02-15

    Natural systems make their natural capital and ecosystem services available to human economy. A careful analysis of the interplay between natural and human-made capital is needed to prevent natural capital being overexploited for present economic benefits, affecting lifestyles and wellbeing of future generations. In this study, the emergy synthesis is used to evaluate the natural and the human-made capital of Campania region (southern Italy) by accounting for the environmental support directly and indirectly provided by nature to resource generation. Furthermore, geographic information system (GIS) models are integrated with the emergy accounting procedure to generate maps of the spatial patterns of both natural and human-made capital distribution. Regional storages of natural and human-made capital are identified and evaluated in emergy units (seJ). The human-made capital of the Campania region (6.29E+24seJ) results to be about 11 times higher than the natural capital (5.69E+23seJ) due to the past and present exploitation of the natural resources needed to generate it over time. Moreover, by overlaying the total natural capital map and the total human-made capital map with a map of the protected areas within the region, only the 19% of the regional natural capital appears to be concentrated within protected areas, while most of it (81%) is concentrated outside. These findings suggest that the conservation of natural resources is also necessary outside protected areas by means of suitable policies, directives and investments. The human-made capital is mainly concentrated (88%) inside non-protected areas and interacts with the local natural capital. A management of the interactions between the two categories of wealth is crucial to prevent that the growth of human-made storages degrades the natural ecosystems and the environment. The proposed emergy-GIS framework reveals to be a useful tool for environmental planning and resource management aimed to conserve and

  1. [Evaluation of the balance between energy supplement and consumption in patients with serious burn: a problem worth further investigation].

    Science.gov (United States)

    Peng, Xi

    2013-08-01

    The energy expenditure of burn patients can be determined accurately by indirect calorimetry measurement, or estimated approximately with energy expenditure equations. However, the energy requirement is not entirely equal to energy expenditure in the whole process of burn injury. The energy consumption induced by hyper catabolism is increased significantly, and on the other hand, the ability of nutrient absorption and anabolism decreased remarkably in the early phase of burn injury, thus leading to imbalance between energy consumption and demand. However, energy supplement as calculated according to energy consumption may induce overfeeding in the early phase of burn injury. Excessive nutrients intake can not be fully utilized to decrease hypermetabolic reaction, but it might exacerbate metabolic disorder. Therefore, the energy supplement should be lower than energy consumption during the early stage of burns. With the advance of disease course, the internal environment becomes stable gradually, ending in a balance between anabolism and catabolism. Energy supplement should be increased gradually according to energy consumption. During the convalescent period, anabolic metabolism exceeds catabolic metabolism, therefore the quantity of energy supplement should be moderately higher than that of energy consumption. Thus, the energy consumption and energy supplement may reach a balance during the whole course of treatment. The purpose of the article is to analyze and discuss how to estimate energy expenditure precisely and evaluate energy requirement correctly, in order to reach a balance between energy consumption and supplement during a long course of treatment for severe burn patients.

  2. [{sup 125}I]{beta}-CIT-FE and [{sup 125}I]{beta}-CIT-FP are superior to [{sup 125}I]{beta}-CIT for dopamine transporter visualization: Autoradiographic evaluation in the human brain

    Energy Technology Data Exchange (ETDEWEB)

    Guenther, Ilonka; Hall, Haakan; Halldin, Christer; Swahn, Carl-Gunnar; Farde, Lars; Sedvall, Goeran

    1997-10-01

    The binding of the three dopamine transporter radioligands ([{sup 125}I]{beta}-CIT, [{sup 125}I]{beta}-CIT-FE, and [{sup 125}I]{beta}-CIT-FP) was studied using whole-hemisphere autoradiography on postmortem human brains. The autoradiograms revealed an intense and homogeneous labeling of the nucleus caudatus and putamen but also to varying extent to serotonergic and noradrenergic transporters of neocortex and thalamus. The order of specificity estimated (striatum over neocortex ratios) was {beta}-CIT-FP > {beta}-CIT-FE >> {beta}-CIT, suggesting that {beta}-CIT-FE and {beta}-CIT-FP should be preferred for in vivo studies of the dopamine transporter in the human brain.

  3. Women's development key to MCH/FP.

    Science.gov (United States)

    1991-05-01

    The Sri Lankan government has included women in its development process thereby raising literacy levels to 91% for urban women and 87% for rural women. Their successful participation has in turn resulted in improvements in maternal and child health (MCH) and family planning (FP) acceptance. Indeed MCH/FP promotion could not have occurred without their participation in development. Since the 1960s, the Health and Women's Affairs Ministry continues to provide broad support for grass roots health care, such as strengthening the capacity of local clinics to increase coverage of health monitoring for women and children. There fore infant mortality in Sri Lanka has decreased from 47.5 in 1970 to 34 in 1980 to 19 in 1989. In addition, the total fertility rate fell from 5 in 1962-1964 to 3.4 in 1980-1982 to 2.8 in 1982-1987. The Ministry initiated its Integrated FP, Nutrition, and Parasite Control Project (IP) in 8 pilot areas in 1981. IP continues to encourage women's developed and MCH/FP at the grass roots level. In fact, FP acceptance rates increased from 31.8% in 1980 to 59% in 1989 in Nakulugamuwa and from 2.3% in 1980 to 70.5% in 1989 in Galnewa. The MCH component operating from community level clinics includes growth monitoring and immunization. Project activities include construction of latrines and wells, promotion of regular health examinations for mothers and children, FP education, counseling, nutrition promotion for children, and training programs for health staff, community volunteers, mothers' groups, and teachers. The volunteers form a link between the community and government health workers. Mothers' groups participate in school nutrition programs, home gardening, and income generation. Parasite control is consequently accomplished by community health and environmental sanitation promotion.

  4. On FP-small Injectivity And J-injectivity%FP-small内射性与J-内射性

    Institute of Scientific and Technical Information of China (English)

    向跃明; 王树桂

    2013-01-01

    作为FP-内射性的推广,在文中引入了FP-small内射性.研究了右FP-small内射环的一些性质.利用FP-small内射性给出了FP-环与QF-环的一些新刻画.同时,还研究了环模的J-内射性.构造了一些相关例子.

  5. Improving midwives' knowledge and skills. JICA Reproductive Health Project. MCH / FP Center.

    Science.gov (United States)

    Do Thi Mui

    1999-01-01

    The Maternal and Child Health and Family Planning (MCH/FP) Center in Nghe An Province, Vietnam, has contributed to the promotion of family planning throughout the province. The institute's effective work has led to an increase in the contraceptive prevalence rate from 57.8% in 1995 to 76.3% in 1999. In addition, the law has designated the MCH/FP Center to 1) manage the MCH/FP program in Nghe An Province; 2) provide quality contraceptives required in Nghe An Province; 3) provide MCH/FP services in Vinh City; 4) instruct and supervise MCH/FP services rendered by District Health Centers and Commune Health Centers; 5) conduct training for health personnel; 6) conduct research, evaluation and monitoring; and 7) implement national programs. In June 1997, the MCH/FP Center executed a technical cooperation project on reproductive health funded by the Japan International Cooperation Agency. One of its major objectives has been the capacity building of the MCH/FP Center for training and service as a focal point of reproductive health promotion in Nghe An Province. Overall, the training programs provided by the project have been producing good results. Primary and secondary midwives and assistant doctors who participated in the JICA-training course are very pleased to be given the chance to review their knowledge and skills and to learn new techniques, and manage high-risk cases.

  6. What Is Bioethics Worth?

    Science.gov (United States)

    Solomon, Mildred Z

    2016-09-01

    What is bioethics to do when it strives to assess the quality of its research and scholarship and when it needs to justify its work to prospective funders, especially a funder like the National Institutes of Health that privileges empirical discovery? In "A Conceptual Model for the Translation of Bioethics Research and Scholarship," Debra Mathews and colleagues take an important first step at advancing an answer. The authors describe what they call a translational process, whereby bioethics "outputs" are translated into changes of three types: in thinking, practice, and policy. It goes nearly without saying that bioethics research and scholarship must be held accountable for changes in thinking. What raison d'etre do we have if not to deepen thinking, question assumptions, and encourage ourselves and others to examine hard issues from novel approaches? Assuredly it is hard to assess quality, and even harder to assess specific changes in thinking for which high-quality scholarship may be responsible, but it is a necessary goal and one for which we should strive without reservation. Bioethics should also affect policy and practice. We should document how it does and the extent to which it does as often and as prominently as possible. However, let us be wary of pinning too much on practice and policy changes as the primary way of establishing bioethics' worth.

  7. FACTORS AFFECTING MASS MEDIA FP PROGRAMS ON CURRENT USE OF CONTRACEPTION IN BANGLADESH

    OpenAIRE

    Islam, M. Amirul; Kabir, M.

    1998-01-01

    In this paper the significant role of mass media and factors affecting it have been investigated. . Mass media has played an important role in the success of Bangladesh family planning programs. Different mass media are employed to disseminate FP-MCH messages. Evaluation of the impact of mass media exposures on FP-MCH programs would provide new directions and strategy for its effectiveness. In this study a total of 3100 currently married women from all over Bangladesh were interviewed. The ai...

  8. Flu Shots Are Worth It

    Science.gov (United States)

    ... news/fullstory_162776.html Flu Shots Are Worth It Vaccine most important for young kids, seniors, people ... may not keep you from getting the flu, it will limit the severity and duration of the ...

  9. 帕金森病患者临床量表UPDRS与18F-FP-CIT PET-DAT功能显像相关性的研究%A Study of Evaluating the Correlation Between the Subscale Ⅱ, Ⅲ and Ⅴ of UPDRS and the [18F]-FP-CIT PET Dopamine Transports in Parkinsonian Striatum

    Institute of Scientific and Technical Information of China (English)

    王坚; 蒋雨平; 管一晖; 项景德; 陈正平; 赵军; 苏惠琳; 杨莉芹; 郭丽萍; 邬剑军; 丁正同

    2003-01-01

    目的:研究临床中普遍应用的UPDRS量表中第Ⅱ、Ⅲ和Ⅴ部分评分与多巴胺转运体(Dopamine transporter,DAT)PET功能显像的相关性,推断这些评分在帕金森病(Parkinson disease,PD)临床应用的可靠性.方法:以18F标记的FP-CIT为特异性配体,应用PET检测了31例原发性PD患者双侧基底节区(包括尾状核、前壳核和后壳核)DAT数量.将这些患者的UPDRS中第Ⅱ、Ⅲ和Ⅴ部分的临床评分与双侧基底节不同区域DAT均值进行相关性分析.结果:UPDRSⅡ、Ⅲ、Ⅴ评分与尾状核、前壳核和后壳核DAT呈显著负相关.它们与后壳核DAT的相关系数r分别为-0.363,-0.473及-0.532.在UPDRS Ⅲ中的PD主要症状评分中,肌强直评分与上述3个基底节不同区域DAT均呈显著负相关,动作迟缓评分仅与后壳核DAT呈显著负相关,而震颤评分与这3个区域中的任何区域DAT均无相关性.结论:UPDRS Ⅱ、Ⅲ、Ⅴ评分均能客观反映PD患者的严重程度,其中UPDRS Ⅲ相对更全面可靠.PD患者震颤发生的机制可能与黑质纹状体通路障碍无关.

  10. A hybrid Michelson-FP interference fiber sensor

    Science.gov (United States)

    Liu, Zhihai; Zhang, Yaxun; Wang, Zhenzhen; Zhang, Yu; Zhao, Enming; Zhou, Ai; Yuan, Libo

    2015-09-01

    A novel hybrid Michelson-FP (M-FP) interference fiber sensor based on a twin-core fiber has been proposed. It consists of an in-fiber integrated Michelson interferometer and an air FP cavities. The radial strain and axial strain sensing properties are explored and analyzed. By using this novel structure, we can measure radial strain and axial strain simultaneously.

  11. An algorithm for DLP on anomalous elliptic curves over Fp

    Institute of Scientific and Technical Information of China (English)

    祝跃飞; 裴定一

    2002-01-01

    This paper improves the method of discrete logarithm on anomalous elliptic curves, and establishes an isomorphism from E(Fp) to Fp which can be more easily implemented. Fruthermore, we give an optimized algorithm for discrete logarithm on anomalous elliptic curves E(Fp).

  12. Evaluation of a second trimester triple marker screening test for fetal status using alpha-fetoprotein (aFP), human chorionic gonadotropin (hCG) and unconjugated estriol (uE{sub 3})

    Energy Technology Data Exchange (ETDEWEB)

    Mi, Seong Young; Kim, Jong Ho; Choi, Seung Hun [Chung Ang Gil Hospital, Inchon (Korea, Republic of)

    1997-07-01

    Our purpose was to assess the utility of maternal serum triple-marker screening test using alpha-fetoprotein (aFP), human Chorionic Gonadotropin (hCG) and unconjugated Estriol (uE{sub 3}) for fetal chromosomal abnormalities. 1,767 venous blood samples (4ml) between 15 and 20 week's gestation for maternal serum screening from January to October 1996, were tested with Kodak Amerix-M triple marker radioimmunoassay kits. Risk analysis was achieved with interpretive software such as Alpha (LMS, Kodak Clinical Diagnostics). Marker levels are transformed into multiples of median (MOM), which represent an interpretation of (weight regressed) patient marker levels relative to regressed median levels for stated gestation. By multivariate anaysis, the three MOM values are combined to generate a liklihood ratio. Calculation of a patient, risk is the product of liklihood ratio and age-related risk. Risk assessment is weight for maternal age. The median values of aFP, hCG and uE{sub 3} were well correlated with gestational age, respectively (r=0.94, p=0.003; r=-0.97, p=0.029; r=0.99, p<0.001, respectively). The median value of hCG were correlated withmateral age (r=0.13, p=0.04) but those of aFP and eU{sub 3} weren't (r=-0.17, p=0.22; r=0.36, p=0.09, respectively). The values of aFP, CG and uE{sub 3} between pregnancy younger than 35 years-old (n=87) and older than that (n=1640) were 51.67{+-}27.44, vs 54.65{+-}126.36, 46.45{+-}30.08 vs 51.33{+-}38.50 and 8.01{+-}11.01 vs 6.68{+-}7.23, respectively but all of them failed to show significant differences. A second-trimester risk for trisomy 21 > or = 1:270 was considered screen positive. Patients were screen positive for trisomy 21 if aFP < or 0.7 multiples of median (MOM), hCG> or 2.1 MOM and E{sub 3} < or 0.7 MOM. Patients were screen positive for neural tube defect if aFP >2.5 MOM. The initial screen-positive rate for both Down' syndrome and neural tube defect were 1.46% (26/1767); 0.73% (13/1767) with each other

  13. Hilbert-Huang Transformation Based Analyses of FP1, FP2, and Fz Electroencephalogram Signals in Alcoholism.

    Science.gov (United States)

    Lin, Chin-Feng; Su, Jiun-Yi; Wang, Hao-Min

    2015-09-01

    Chronic alcoholism may damage the central nervous system, causing imbalance in the excitation-inhibition homeostasis in the cortex, which may lead to hyper-arousal of the central nervous system, and impairments in cognitive function. In this paper, we use the Hilbert-Huang transformation (HHT) method to analyze the electroencephalogram (EEG) signals from control and alcoholic observers who watched two different pictures. We examined the intrinsic mode function (IMF) based energy distribution features of FP1, FP2, and Fz EEG signals in the time and frequency domains for alcoholics. The HHT-based characteristics of the IMFs, the instantaneous frequencies, and the time-frequency-energy distributions of the IMFs of the clinical FP1, FP2, and Fz EEG signals recorded from normal and alcoholic observers who watched two different pictures were analyzed. We observed that the number of peak amplitudes of the alcoholic subjects is larger than that of the control. In addition, the Pearson correlation coefficients of the IMFs, and the energy-IMF distributions of the clinical FP1, FP2, and Fz EEG signals recorded from normal and alcoholic observers were analyzed. The analysis results show that the energy ratios of IMF4, IMF5, and IMF7 waves of the normal observers to the refereed total energy were larger than 10 %, respectively. In addition, the energy ratios of IMF3, IMF4, and IMF5 waves of the alcoholic observers to the refereed total energy were larger than 10 %. The FP1 and FP2 waves of the normal observers, the FP1 and FP2 waves of the alcoholic observers, and the FP1 and Fz waves of the alcoholic observers demonstrated extremely high correlations. On the other hand, the FP1 waves of the normal and alcoholic observers, the FP1 wave of the normal observer and the FP2 wave of the alcoholic observer, the FP1 wave of the normal observer and the Fz wave of the alcoholic observer, the FP2 waves of the normal and alcoholic FP2 observers, and the FP2 wave of the normal observer and

  14. Removal of transposon target sites from the Autographa californica multiple nucleopolyhedrovirus fp25k gene delays, but does not prevent, accumulation of the few polyhedra phenotype.

    Science.gov (United States)

    Giri, Lopamudra; Li, Huarang; Sandgren, David; Feiss, Michael G; Roller, Richard; Bonning, Bryony C; Murhammer, David W

    2010-12-01

    Low-cost, large-scale production of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) using continuous insect cell culture is seriously hindered by the accumulation of AcMNPV mutants. Specifically, few-polyhedra (FP) mutants, with a reduced yield of occluded virus (polyhedra) and decreased infectivity, usually accumulate upon passaging in cell culture. FP mutations result from transposon insertions in the baculovirus fp25k gene, leading to significantly reduced levels of FP25K protein synthesis. This study evaluated the effects of removing the transposon insertion sites from the wild-type baculovirus fp25k gene; the mutated virus was denoted Ac-FPm. Specifically, this study involved a detailed comparison of wild-type (WT) AcMNPV and Ac-FPm with regard to the proportion of cells having polyhedra, number of polyhedra per cell, the fraction of empty polyhedra, number of occlusion-derived viruses per polyhedron, number of nucleocapsids in the nuclei, FP25K protein synthesis and genetic analysis of the fp25k gene. Removal of TTAA transposon insertion sites from the fp25k gene stabilized FP25K protein synthesis and delayed the appearance of the FP phenotype from passage 5 to passage 10. Electron micrographs revealed that more virus particles were found inside the nuclei of cells infected with Ac-FPm than in the nuclei of cells infected with WT AcMNPV (at passage 10). Abnormalities, however, were observed in envelopment of nucleocapsids and virus particle occlusion within Ac-FPm polyhedra. Thus, the FP phenotype appeared in spite of continued FP25K protein synthesis, suggesting that mechanisms other than fp25k gene disruption can lead to the FP phenotype.

  15. Web Classification Using DYN FP Algorithm

    Directory of Open Access Journals (Sweden)

    Bhanu Pratap Singh

    2014-01-01

    Full Text Available Web mining is the application of data mining techniques to extract knowledge from Web. Web mining has been explored to a vast degree and different techniques have been proposed for a variety of applications that includes Web Search, Classification and Personalization etc. The primary goal of the web site is to provide the relevant information to the users. Web mining technique is used to categorize users and pages by analyzing users behavior, the content of pages and order of URLs accessed. In this paper, proposes an auto-classification algorithm of web pages using data mining techniques. The problem of discovering association rules between terms in a set of web pages belonging to a category in a search engine database, and present an auto – classification algorithm for solving this problem that are fundamentally based on FP-growth algorithm

  16. Network Intrusion Detection Using FP Tree Rules

    Directory of Open Access Journals (Sweden)

    P Srinivasulu

    2009-07-01

    Full Text Available In the faceless world of the Internet, online fraud is one of the greatest reasons of loss for web merchants. Advanced solutions are needed to protect e-businesses from the constant problems of fraud. Many popular fraud detection algorithms require supervised training, which needs human intervention to prepare training cases. Since it is quite often for an online transaction database to have Terabyte-level storage, human investigation to identify fraudulent transactions is very costly. This paper describes the automatic design of user profiling method for the purpose of fraud detection. We use a FP (Frequent Pattern Tree rule-learning algorithm to adaptively profile legitimate customer behavior in a transaction database. Then the incoming transactions are compared against the user profile to uncover the anomalies. The anomaly outputs are used as input to an accumulation system for combining evidence to generate high-confidence fraud alert value. Favorable experimental results are presented.

  17. Network Intrusion Detection Using FP Tree Rules

    CERN Document Server

    Srinivasulu, P; Babu, I Ramesh

    2010-01-01

    In the faceless world of the Internet,online fraud is one of the greatest reasons of loss for web merchants.Advanced solutions are needed to protect e businesses from the constant problems of fraud.Many popular fraud detection algorithms require supervised training,which needs human intervention to prepare training cases.Since it is quite often for an online transaction database to ha e Terabyte level storage,human investigation to identify fraudulent transactions is very costly.This paper describes the automatic design of user profiling method for the purpose of fraud detection.We use a FP (Frequent Pattern) Tree rule learning algorithm to adaptively profile legitimate customer behavior in a transaction database.Then the incoming transactions are compared against the user profile to uncover the anomalies The anomaly outputs are used as input to an accumulation system for combining evidence to generate high confidence fraud alert value. Favorable experimental results are presented.

  18. Mining Maximal Frequent Patterns in a Unidirectional FP-tree

    Institute of Scientific and Technical Information of China (English)

    SONG Jing-jing; LIU Rui-xin; WANG Yan; JIANG Bao-qing

    2006-01-01

    Becausemining complete set of frequent patterns from dense database could be impractical, an interesting alternative has been proposed recently. Instead of mining the complete set of frequent patterns, the new model only finds out the maximal frequent patterns, which can generate all frequent patterns. FP-growth algorithm is one of the most efficient frequent-pattern mining methods published so far. However,because FP-tree and conditional FP-trees must be two-way traversable, a great deal memory is needed in process of mining. This paper proposes an efficient algorithm Unid_FP-Max for mining maximal frequent patterns based on unidirectional FP-tree. Because of generation method of unidirectional FP-tree and conditional unidirectional FP-trees, the algorithm reduces the space consumption to the fullest extent. With the development of two techniques:single path pruning and header table pruning which can cut down many conditional unidirectional FP-trees generated recursively in mining process, Unid_ FP-Max further lowers the expense of time and space.

  19. Dynamic rod worth simulation study for a sodium-cooled TRU burner

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sang Ji; Ha, Pham Nhu Viet, E-mail: phamha@kaeri.re.kr; Lee, Min Jae; Kang, Chang Mu

    2015-12-15

    Highlights: • Dynamic rod worth calculation methodology for a sodium-cooled TRU burner was developed. • The spatial weighting functions were relatively insensitive to control rods position. • The simulated pseudo detector response agreed well with the calculated core power. • The simulated dynamic rod worths compared well against the simulated static values. • Impact of individual detector on the simulated dynamic worth was evaluated. - Abstract: This paper presents a preliminary dynamic rod worth simulation study for a TRU burner core mockup of the PGSFR (Korean Prototype Gen-IV Sodium-cooled Fast Reactor) named BFS-76-1A so as to establish a calculation methodology for evaluating the rod worth of the PGSFR. The simulation method was mainly based on a three-dimensional multi-group nodal diffusion transient code for fast reactors in which the rod drop simulation for the BFS-76-1A was performed and all the fuel assemblies were taken into account for the detector response calculation. Then the dynamic rod worths were inferred from the simulated detector responses using an inverse point kinetics model and compared against the simulated static worths. The results show good agreement between the simulated pseudo detector response and the calculated core power as well as between the simulated dynamic and static rod worths, and thus indicate that the dynamic rod worth simulation method developed in this work can be applied to the rod worth estimation and validation for the PGSFR.

  20. European multicentre database of healthy controls for [(123)I]FP-CIT SPECT (ENC-DAT)

    DEFF Research Database (Denmark)

    Varrone, Andrea; Dickson, John C; Tossici-Bolt, Livia;

    2013-01-01

    Dopamine transporter (DAT) imaging with [(123)I]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect...... of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [(123)I]FP-CIT SPECT scans in healthy controls....

  1. Contingencies of self-worth.

    Science.gov (United States)

    Crocker, J; Wolfe, C T

    2001-07-01

    Research on self-esteem has focused almost exclusively on level of trait self-esteem to the neglect of other potentially more important aspects such as the contingencies on which self-esteem is based. Over a century ago, W. James (1890) argued that self-esteem rises and falls around its typical level in response to successes and failures in domains on which one has staked self-worth. We present a model of global self-esteem that builds on James' insights and emphasizes contingencies of self-worth. This model can help to (a) point the way to understanding how self-esteem is implicated in affect, cognition, and self-regulation of behavior; (b) suggest how and when self-esteem is implicated in social problems; (c) resolve debates about the nature and functioning of self-esteem; (d) resolve paradoxes in related literatures, such as why people who are stigmatized do not necessarily have low self-esteem and why self-esteem does not decline with age; and (e) suggest how self-esteem is causally related to depression. In addition, this perspective raises questions about how contingencies of self-worth are acquired and how they change, whether they are primarily a resource or a vulnerability, and whether some people have noncontingent self-esteem.

  2. Cyclic Codes Over Fp +uFp +vFp%环F_p+uF_p+vF_p上循环码

    Institute of Scientific and Technical Information of China (English)

    唐刚; 许小芳

    2012-01-01

    本文讨论了有限非链环R=Fp+uFp+vFp上的循环码.通过环R上的循环码与多项式环Rn=(Fp+uFp+vFp)[x]/(xn-1)的理想的对应关系给出了R上循环码的刻画.最后定义了一个Gray映射,并刻画了R上的循环码在该映射下的像.%In this paper, cyclic codes over the ring R=Fp +uFp +vFp are discussed, nite chain ring. By using the corresponding relationship between the cyclic codes over the ring R. = (Fp + uFp + vFp ) [x]/(xn- 1 ) cyclic codes over the ring R are characterized. tained and the image of cyclic codes over the ring R is characterized. where the ring R is not a firing R and the idealsin the Finally, a Gray-map is obtained and the image of cyclic codes over the ring R is characterized.

  3. Feasibility of flat-panel volumetric computed tomography (fpVCT) in experimental small animal imaging of osteoporosis - initial experience; Erste Erfahrungen mit einem Flaechendetektor-Volumen-CT (fpVCT) in der experimentellen Osteoporosediagnostik am Kleintiermodell

    Energy Technology Data Exchange (ETDEWEB)

    Valencia, R.; Dullin, C.; Herrmann, K.P.; Kluever, I.; Zaroban, A.; Knollmann, F. [Universitaetsklinikum Goettingen (Germany). Abteilung Diagnostische Radiologie, Goettingen; Stuermer, E.K.; Sehmisch, S. [Universitaetsklinikum Goettingen (Germany). Klinik fuer Unfallchirurgie, Plastische und Wiederherstellungschirurgie; Funke, M. [Klinikum Mittelbaden, Baden-Baden (Germany). Radiologische Klinik an der Stadtklinik

    2006-10-15

    Flat-panel volumetric computed tomography (fpVCT) is a new, noninvasive CT imaging modality with increased isotropic resolution. Technical details, potential applications, and our initial experience with a fpVCT prototype scanner in the imaging of osteoporosis in a rat model are presented. To date, 21 rats have been investigated in vivo with fpVCT. Pharmacologic effects on bone mineral density (BMD) and structure were of special interest. Image evaluation focussed on the second lumbar vertebra and the left femoral bone. To validate measurement results, BMD values calculated with fpVCT were correlated with results of BMD measurements from ashing of the second lumbar vertebra and femoral bones. Our initial results show that fpVCT is capable of detecting differences in BMD between ovariectomized rats treated with estradiol and a control group with high statistical significance (p<0.05), corresponding to ashing as the gold standard. In a rat model, fpVCT imaging is especially useful in longitudinal in vivo investigations of BMD measures. Spatial resolution of up to 150 {mu}m allows imaging of the trabecular structure only in human cadaveric bones. (orig.) [German] Die Flaechendetektor-Volumen-Computertomographie (fpVCT) ist eine neuartige CT-Bildgebungstechnik, die eine gesteigerte isotrope Ortsaufloesung ermoeglicht. In dieser Arbeit wird ueber Technik, Anwendungsmoeglichkeiten und erste Erfahrungen beim Einsatz eines fpVCT-Prototyps in der experimentellen Diagnostik der Osteoporose am Rattenmodell berichtet. Bisher konnten 21 Ratten in vivo am fpVCT untersucht werden. Von besonderem Interesse waren Medikamentenwirkungen auf Knochendichte (''bone mineral density'', BMD) und -struktur. Die Auswertung der gewonnenen Bilddaten fokussierte sich auf den 2. Lendenwirbelkoerper und das linke Femur. Um die Messergebnisse zu ueberpruefen, wurden die mittels fpVCT errechneten BMD-Werte mit den Ergebnissen der Dichtemessung der veraschten 2. LWK und Femora

  4. Social Construction of Skill: Gender, Power, and Comparable Worth.

    Science.gov (United States)

    Steinberg, Ronnie J.

    1990-01-01

    Pressures that contribute to conventional definitions of skill are uncovered through identification of sources of gender bias in job evaluation systems. Pay equity initiatives are examined to highlight process by which new definitions of skill are constructed or blocked. Demonstrates that comparable worth research can engender understanding of…

  5. Unsustainable Growth, Hyper-Competition, and Worth in Life Science Research: Narrowing Evaluative Repertoires in Doctoral and Postdoctoral Scientists' Work and Lives

    Science.gov (United States)

    Fochler, Maximilian; Felt, Ulrike; Müller, Ruth

    2016-01-01

    There is a crisis of valuation practices in the current academic life sciences, triggered by unsustainable growth and "hyper-competition." Quantitative metrics in evaluating researchers are seen as replacing deeper considerations of the quality and novelty of work, as well as substantive care for the societal implications of research.…

  6. Global scaling for semi-quantitative analysis in FP-CIT SPECT.

    Science.gov (United States)

    Kupitz, D; Apostolova, I; Lange, C; Ulrich, G; Amthauer, H; Brenner, W; Buchert, R

    2014-01-01

    Semi-quantitative characterization of dopamine transporter availability from single photon emission computed tomography (SPECT) with 123I-ioflupane (FP-CIT) is based on uptake ratios relative to a reference region. The aim of this study was to evaluate the whole brain as reference region for semi-quantitative analysis of FP-CIT SPECT. The rationale was that this might reduce statistical noise associated with the estimation of non-displaceable FP-CIT uptake. 150 FP-CIT SPECTs were categorized as neurodegenerative or non-neurodegenerative by an expert. Semi-quantitative analysis of specific binding ratios (SBR) was performed with a custom-made tool based on the Statistical Parametric Mapping software package using predefined regions of interest (ROIs) in the anatomical space of the Montreal Neurological Institute. The following reference regions were compared: predefined ROIs for frontal and occipital lobe and whole brain (without striata, thalamus and brainstem). Tracer uptake in the reference region was characterized by the mean, median or 75th percentile of its voxel intensities. The area (AUC) under the receiver operating characteristic curve was used as performance measure. The highest AUC of 0.973 was achieved by the SBR of the putamen with the 75th percentile in the whole brain as reference. The lowest AUC for the putamen SBR of 0.937 was obtained with the mean in the frontal lobe as reference. We recommend the 75th percentile in the whole brain as reference for semi-quantitative analysis in FP-CIT SPECT. This combination provided the best agreement of the semi-quantitative analysis with visual evaluation of the SPECT images by an expert and, therefore, is appropriate to support less experienced physicians.

  7. Properties of the streptomycete temperate bacteriophage FP43.

    Science.gov (United States)

    Hahn, D R; McHenney, M A; Baltz, R H

    1991-06-01

    FP43 is a temperate bacteriophage for Streptomyces griseofuscus that forms plaques on many Streptomyces species. FP43 virions contain 56 kb of double-strand DNA that is circularly permuted and terminally redundant, and contains 65% G + C. A physical map of the FP43 genome was constructed, and the origin for headful packaging (pac) was localized to an 8.8-kb region of the genome (hft) that mediates high-frequency transduction by FP43 of plasmid pRHB101. The phage attachment site (attP), a replication origin (rep), a region that inhibits plaque formation (pin), and a 3-kb deletion (rpt) that caused a 100-fold reduction in plasmid transduction were mapped.

  8. Investigating FP Tau’s protoplanetary disk structure through modeling

    Science.gov (United States)

    Brinjikji, Marah; Espaillat, Catherine

    2017-01-01

    This project presents a study aiming to understand the structure of the protoplanetary disk around FP Tau, a very young, very low mass star in the Taurus star-forming region. We have gathered existing optical, Spitzer, Herschel and submillimeter observations to construct the spectral energy distribution (SED) of FP Tau. We have used the D’Alessio et al (2006) physically self-consistent irradiated accretion disk model including dust settling to model the disk of FP Tau. Using this method, the best fit for the SED of FP Tau is a model that includes a gap located 10-20 AU away from the star. This gap is filled with optically thin dust that separates the optically thick dust in the outer disk from the optically thick dust in the inner disk. These characteristics indicate that FP Tau’s protostellar system is best classified as a pre-transitional disk. Near-infrared interferometry in the K-Band from Willson et al 2016 indicates that FP Tau has a small gap located 10-20 AU from the star, which is consistent with the model we produced, lending further support to the pre-transitional disk interpretation. The most likely explanation for the existence of a gap in the disk is a forming planet.

  9. Quantification of Azospirillum brasilense FP2 Bacteria in Wheat Roots by Strain-Specific Quantitative PCR.

    Science.gov (United States)

    Stets, Maria Isabel; Alqueres, Sylvia Maria Campbell; Souza, Emanuel Maltempi; Pedrosa, Fábio de Oliveira; Schmid, Michael; Hartmann, Anton; Cruz, Leonardo Magalhães

    2015-10-01

    Azospirillum is a rhizobacterial genus containing plant growth-promoting species associated with different crops worldwide. Azospirillum brasilense strains exhibit a growth-promoting effect by means of phytohormone production and possibly by N2 fixation. However, one of the most important factors for achieving an increase in crop yield by plant growth-promoting rhizobacteria is the survival of the inoculant in the rhizosphere, which is not always achieved. The objective of this study was to develop quantitative PCR protocols for the strain-specific quantification of A. brasilense FP2. A novel approach was applied to identify strain-specific DNA sequences based on a comparison of the genomic sequences within the same species. The draft genome sequences of A. brasilense FP2 and Sp245 were aligned, and FP2-specific regions were filtered and checked for other possible matches in public databases. Strain-specific regions were then selected to design and evaluate strain-specific primer pairs. The primer pairs AzoR2.1, AzoR2.2, AzoR5.1, AzoR5.2, and AzoR5.3 were specific for the A. brasilense FP2 strain. These primer pairs were used to monitor quantitatively the population of A. brasilense in wheat roots under sterile and nonsterile growth conditions. In addition, coinoculations with other plant growth-promoting bacteria in wheat were performed under nonsterile conditions. The results showed that A. brasilense FP2 inoculated into wheat roots is highly competitive and achieves high cell numbers (∼10(7) CFU/g [fresh weight] of root) in the rhizosphere even under nonsterile conditions and when coinoculated with other rhizobacteria, maintaining the population at rather stable levels for at least up to 13 days after inoculation. The strategy used here can be applied to other organisms whose genome sequences are available.

  10. Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons

    DEFF Research Database (Denmark)

    Koch, Walter; Unterrainer, Marcus; Xiong, Guoming

    2014-01-01

    PURPOSE: Apart from binding to the dopamine transporter (DAT), [(123)I]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate...... error) of 8.2 ± 1.3 % for the thalamus and 6.8 ± 2.9 % for the pons was shown. CONCLUSION: The potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [(123)I]FP-CIT scans in healthy controls. For both...

  11. Comparable investigation in dopamine transporters with 99mTc-TRODAT-1 and 131I-FP-CIT SPECT in Parkinson's disease patients

    Institute of Scientific and Technical Information of China (English)

    LIU Congjin; LIU Xingdang; ZHANG Guangming; LI Ding; WANG Jian; YANG Liqin; JIANG Yuping

    2007-01-01

    Dopamine transporter (DAT) mediates the regulation of dopaminergic function. Two agents of TRODAT-1and FP-CIT were observed in evaluating DAT change of Parkinson's disease (PD). The relationship between them was also evaluated. The results suggested that 99mTc-TRODAT-1 SPECT and 131I-FP-CIT SPECT may serve as sensitiveand objective in vivo markers to reflect the severity of PD. The 99mTc-TRODAT-1 image is more accurate and clearercompared with 131I-FP-CIT.

  12. Net worth and housing equity in retirement

    OpenAIRE

    Sinai, Todd; Nicholas S. Souleles

    2007-01-01

    This paper documents the trends in the life-cycle profiles of net worth and housing equity between 1983 and 2004. The net worth of older households significantly increased during the housing boom of recent years. However, net worth grew by more than housing equity, in part because other assets also appreciated at the same time. Moreover, the younger elderly offset rising house prices by increasing their housing debt, and used some of the proceeds to invest in other assets. We also consider ho...

  13. CERN in FP7: very successful participation so far

    CERN Multimedia

    2009-01-01

    The first two years of the seventh Framework Programme were very successful for CERN – 27 EU projects were selected for funding in 2007 and 2008, with the total EC contribution exceeding 33 million euros.The seventh European Union Framework Programme for research, technological development and demonstration activities (FP7) started on 1 January 2007 and will cover the period from 2007 to 2013. With a total budget of 50.5 billion euros, FP7 is the largest Framework Programme in the history of the EU. FP7 consists of four major sub-programmes, referred to as "Specific Programmes": "Cooperation" is focused on collaborative research projects and is divided into 10 thematic areas. "Ideas" is a new EU programme for funding frontier research in all fields of science. "Capacities" aims at strengthening the research capacities in Europe, including research infrastructures and e-infrastructures. Finally, "People" succeeds the p...

  14. What are the forests worth?

    Science.gov (United States)

    Fellows, L

    1992-05-30

    The Earth is a finite environment, thus growth cannot occur indefinitely. Eventually we will run out of space, resources, or anything else that is also finite. Once this fact is recognized, it becomes clear that we must develop in a sustainable way so that we can endure into the future. Overpopulation, vegetation destruction, and pollution are all serious threats to our finite environment. Traditionally, change has been to expensive and politically destabilizing. However, extensive changes in our modes of living must be made so that they become sustainable. In both developed and developing countries, consumptive growth must be replaced with sustainable development. Many developing countries are currently selling their natural resources to the developed countries. When they run out of resources, they will be truly poor. All governments must recognize the value of forests. It is estimated that in terms of medical uses for forest products alone, they will be worth US$11-12 billion (1990 dollars) by 2050. This constitutes a large portion of developing countries economies. Also, 80% of the population of developing countries rely on natural, traditional medicines made from forest products. Even in the US 25% of prescription drugs are based on phytochemicals. Now the drug companies are actively pursuing these resources for their products. It is estimated that 95% of the world species have not been assayed for their chemical value. Technology and money are not the obstacles to sustainable development and forest conservation. It is will and attitude that must be radically changed in order to protect the forests for the ecological and economic value.

  15. Detection of thiopurine s-methyltransferase mutations by template directed determinator in incorporation with fluorescence polarization(TDI-FP)

    Institute of Scientific and Technical Information of China (English)

    白玉杰; 赵锦荣; 张文红; 薛丽; 郭晏海; 闫小君

    2003-01-01

    Objective:To develop a new method for the detection of TPMT gene mutations and determine thefrequencies of four TPM alleles,TPMT*1,*3A,*3B and *3C in a healthy Chinese population.Methods:A TDI-FP assay system was set up in out lab.To evaluate this system,220 healthy individuals were analyzed for the polymorphisites at positions 460(G→A)and 719(A→G)of the TPMP gene using our new TDI-FP method.Results:Three TPMP*3C(G460→G719)heterozygotes were identified,TPMP *3A and TPMP *3B were not found.All mutations were confirmed by conventional DNA sequencing analysis.Conclusion:TDI-FP method has proven to be very efficient as a rapid and accurate approach for TPMP genotyping.TPMP *3C was the only polymorphism identified in this clinical samples we have registered.

  16. Uncertainty of Doppler reactivity worth due to uncertainties of JENDL-3.2 resonance parameters

    Energy Technology Data Exchange (ETDEWEB)

    Zukeran, Atsushi [Hitachi Ltd., Hitachi, Ibaraki (Japan). Power and Industrial System R and D Div.; Hanaki, Hiroshi; Nakagawa, Tuneo; Shibata, Keiichi; Ishikawa, Makoto

    1998-03-01

    Analytical formula of Resonance Self-shielding Factor (f-factor) is derived from the resonance integral (J-function) based on NR approximation and the analytical expression for Doppler reactivity worth ({rho}) is also obtained by using the result. Uncertainties of the f-factor and Doppler reactivity worth are evaluated on the basis of sensitivity coefficients to the resonance parameters. The uncertainty of the Doppler reactivity worth at 487{sup 0}K is about 4 % for the PNC Large Fast Breeder Reactor. (author)

  17. Antitumor effects of FP3 in combination with capecitabine on PDTT xenograft models of primary colon carcinoma and related lymphatic and hepatic metastases.

    Science.gov (United States)

    Jin, Ketao; Lan, Huanrong; Xie, Bojian; He, Kuifeng; Xu, Zhenzhen; Li, Guangliang; Han, Na; Teng, Lisong; Cao, Feilin

    2012-07-01

    FP3 is an engineered protein which contains the extracellular domain 2 of VEGF receptor 1 (Flt-1) and extracellular domain 3 and 4 of VEGF receptor 2 (Flk-1, KDR) fused to the Fc portion of human immunoglobulin G 1. Previous studies demonstrated its antiangiogenic effects in vitro and in vivo, and its antitumor activity in vivo. In this study, patient-derived tumor tissue (PDTT) xenograft models of primary colon carcinoma and lymphatic and hepatic metastases were established for assessment of the antitumor activity of FP3 in combination with capecitabine. Xenografts were treated with FP3, capecitabine, alone or in combination. After tumor growth was confirmed, volume and microvessel density in tumors were evaluated. Levels of VEGF, and PCNA in the tumor were examined by immunohistonchamical staining, level of thymidine phosphorylase (TP) was examined by ELISA, and levels of related cell signaling pathways proteins expression were examined by western blotting. FP3 in combination with capecitabine showed significant antitumor activity in three xenograft models (primary colon carcinoma, lymphatic metastasis, and hepatic metastasis). The microvessel density in tumor tissues treated with FP3 in combination with capecitabine was lower than that of the control. Antitumor activity of FP3 in combination with capecitabine was significantly higher than that of each agent alone in three xenograft models (primary colon carcinoma, lymphatic metastasis, and hepatic metastasis). This study indicated that addition of FP3 to capecitabine significantly improved tumor growth inhibition in the PDTT xenograft models of primary colon carcinoma and lymphatic and hepatic metastases.

  18. 12 CFR 263.105 - Statement of net worth.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Statement of net worth. 263.105 Section 263.105... Statement of net worth. (a) General rule. A statement of net worth shall be filed with the application for an award of fees. The statement shall reflect the net worth of the applicant and all affiliates...

  19. 75 FR 78799 - Noise Compatibility Program Notice, Fort Worth Alliance Airport, Fort Worth, TX

    Science.gov (United States)

    2010-12-16

    ... Federal Aviation Administration Noise Compatibility Program Notice, Fort Worth Alliance Airport, Fort... Administration (FAA) announces its findings on the noise compatibility program submitted by the city of Fort Worth, Texas under the provisions of 49 U.S.C. (the Aviation Safety and Noise Abatement Act,...

  20. 78 FR 11094 - Safety Zone; Lake Worth Dredge Operations, Lake Worth Inlet; West Palm Beach, FL

    Science.gov (United States)

    2013-02-15

    ... Guard is establishing a temporary safety zone on Lake Worth Inlet, West Palm Beach, Florida, to provide..., February 20, 2013, dredging operations will be conducted on Lake Worth Inlet in West Palm Beach, Florida... the southwestern corner of Singer Island and then due south across the inlet to Palm Beach...

  1. Do We Need To Train Teachers How To Administer Praise? Self-Worth Theory Says We Do.

    Science.gov (United States)

    Thompson, Ted

    1997-01-01

    The term self-worth protection describes a tendency on the part of certain students to underachieve and at other times to perform well on academic tasks of similar difficulty. The development and maintenance of self-worth protection may be attributed to messages implicit in unproductive evaluative feedback used by teachers. (SLD)

  2. 环F_p+uF_p+…+u~kF_p上的准循环码%Quasi-cyclic codes over Fp+uFp+...+ukFp

    Institute of Scientific and Technical Information of China (English)

    李富林; 朱士信

    2009-01-01

    令R=F_p+uF_p+...+u~kF_p,文章定义了对于n=n_1p~s,环R~n_1到环F~p~kn1p 上的Gray映射,给出了该映射的性质,并由此得出了R环上指数为p~st,长为n=n_1p~s的准循环码与Fp上的准循环码一一对应,其中t|n_1,(n_1,p)=1,从而环R上的准循环码可以看作F_p上的准循环码.%Let R=F_p+uF_p +…+u~kF_p. The Gray map from R~n1 to F~p_p~kn1 is defined,and one of the propositions of this map is given. It is shown that a quasi-cyclic code of length n=n_1p~s with the index p't over R is uniquely equivalent to a quasi-cyclic code of length n=n_1p~s with the index p't over F_p, where t|n_1 ,(n_1,p = 1. Then the quasicyclic code over the ring R can be taken as the quasi-cyclic code over the ring F_p.

  3. Quality care for community-based FP / MCH.

    Science.gov (United States)

    1995-02-01

    The Regional Workshop on Quality Care for Community-based FP/MCH in Asia was organized by the Family Planning Association of Nepal (FPAN) in cooperation with JOICFP and held in Kathmandu, Nepal, December 4-9. Representatives of counterpart organizations in Bangladesh, Laos, Nepal, and the Philippines implementing the UNFPA-supported Sustainable Community-based FP/MCH Project with Special Focus on Women were included among the forty participants. Representatives of China and Vietnam as well as resource persons from Mexico and Japan also attended the event. The workshop was held with the goal of providing participants with effective strategies for promoting quality care for community-based FP/MCH activities based upon the Nepalese experience. The event also provided the opportunity for participants to share experiences, develop strategies for project sustainability, and identify strategies and action plans suitable for their particular country situations. In field trips to Panchkhal, Sunsari, and Morang where the project is being implemented in 26 villages, participants noted the strong community involvement and village leader support. They were also impressed by the communities' awareness of services provided under the project. FPAN has succeeded despite geographical and cultural difficulties in promoting fee-based services toward project sustainability. By paying nominal fees, villagers also enjoy access to drugs and services which may not have been available through the government free of charge. Participants at the end of the workshop recommended the identification of specific indicators and systems for monitoring services and activities, training and orientation at all levels to improve the skills and attitudes of health care workers, the development of potential income-generating activities, the provision of essential FP/MCH equipment, and the equal involvement of men and women at the policy and implementation levels.

  4. Revision of the JENDL FP Fission Yield Data

    Directory of Open Access Journals (Sweden)

    Katakura Jun-ichi

    2016-01-01

    Full Text Available Some fission yields data of JENDL FP Fission Yields Data File 2011 (JENDL/FPY-2011 revealed inadequacies when applied to delayed neutron related subjects. The sensitivity analyses of decay heat summation calculations also showed some problems. From these results the fission yields of JENDL/FPY-2011 have been revised. The present report describes the revision of the yield data by emphasizing the sensitivity analyses.

  5. [{sup 18}F]{beta}-CIT-FP is superior to [{sup 11}C]{beta}-CIT-FP for quantitation of the dopamine transporter

    Energy Technology Data Exchange (ETDEWEB)

    Lundkvist, Camilla; Halldin, Christer; Ginovart, Nathalie; Swahn, Carl-Gunnar; Farde, Lars

    1997-10-01

    {beta}-CIT-FP [N-(3-fluoropropyl)-2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)nortropane] is a cocaine analogue with high affinity for the dopamine transporter. Positron emission tomography (PET) studies with [O-methyl-{sup 11}C]{beta}-CIT-FP ([{sup 11}C]{beta}-CIT-FP) has shown that equilibrium conditions were approached but, however, not reached at the end of measurement. Moreover, metabolite studies of [{sup 11}C]{beta}-CIT-FP in monkey plasma demonstrated a lipophilic-labelled metabolite that may enter the brain. We therefore labelled {beta}-CIT-FP with fluorine-18 in a position that may avoid the formation of labelled lipophilic metabolites. The more long-lived radionuclide ({sup 18}F) was used to allow for measurements over longer time. [N-fluoropropyl-{sup 18}F]{beta}-CIT-FP ([{sup 18}F]{beta}-CIT-FP) was prepared by N-alkylation of nor-{beta}-CIT with [{sup 18}F]fluoropropyl bromide. PET studies were performed in cynomolgus monkeys. [{sup 18}F]{beta}-CIT-FP entered the brain rapidly. There was a high concentration of radioactivity in the striatum and much lower in the thalamus, neocortex, and cerebellum. The striatum-to-cerebellum ratio was about 5 at time of transient equilibrium, which occurred after 60 to 100 min. After pretreatment with GBR 12909, radioactivity in the striatum was markedly reduced, thus indicating specific [{sup 18}F]{beta}-CIT-FP binding to the dopamine transporter. The fraction of unchanged [{sup 18}F]{beta}-CIT-FP determined by HPLC was 10-15% after 140 min. No lipophilic labelled metabolites were detected. The absence of measurable lipophilic labelled metabolites and the occurrence of transient equilibrium within the time of the PET measurement indicate that [{sup 18}F]{beta}-CIT-FP is superior to [{sup 11}C]{beta}-CIT-FP as a PET radioligand for quantification of the dopamine transporter in the human brain.

  6. School Trips: Are They Worth the Effort?

    Science.gov (United States)

    Johnston, Robert

    2015-01-01

    Even the most basic of school trips will require booking places, arranging transport, writing to parents, collecting payments, planning activities, producing worksheets and, of course, endless risk assessments. It always leaves teachers wondering: "is it really worth all this effort?" Robert Johnston believes that every teacher should…

  7. Quantifying data worth toward reducing predictive uncertainty.

    Science.gov (United States)

    Dausman, Alyssa M; Doherty, John; Langevin, Christian D; Sukop, Michael C

    2010-01-01

    The present study demonstrates a methodology for optimization of environmental data acquisition. Based on the premise that the worth of data increases in proportion to its ability to reduce the uncertainty of key model predictions, the methodology can be used to compare the worth of different data types, gathered at different locations within study areas of arbitrary complexity. The method is applied to a hypothetical nonlinear, variable density numerical model of salt and heat transport. The relative utilities of temperature and concentration measurements at different locations within the model domain are assessed in terms of their ability to reduce the uncertainty associated with predictions of movement of the salt water interface in response to a decrease in fresh water recharge. In order to test the sensitivity of the method to nonlinear model behavior, analyses were repeated for multiple realizations of system properties. Rankings of observation worth were similar for all realizations, indicating robust performance of the methodology when employed in conjunction with a highly nonlinear model. The analysis showed that while concentration and temperature measurements can both aid in the prediction of interface movement, concentration measurements, especially when taken in proximity to the interface at locations where the interface is expected to move, are of greater worth than temperature measurements. Nevertheless, it was also demonstrated that pairs of temperature measurements, taken in strategic locations with respect to the interface, can also lead to more precise predictions of interface movement.

  8. Quantifying data worth toward reducing predictive uncertainty

    Science.gov (United States)

    Dausman, A.M.; Doherty, J.; Langevin, C.D.; Sukop, M.C.

    2010-01-01

    The present study demonstrates a methodology for optimization of environmental data acquisition. Based on the premise that the worth of data increases in proportion to its ability to reduce the uncertainty of key model predictions, the methodology can be used to compare the worth of different data types, gathered at different locations within study areas of arbitrary complexity. The method is applied to a hypothetical nonlinear, variable density numerical model of salt and heat transport. The relative utilities of temperature and concentration measurements at different locations within the model domain are assessed in terms of their ability to reduce the uncertainty associated with predictions of movement of the salt water interface in response to a decrease in fresh water recharge. In order to test the sensitivity of the method to nonlinear model behavior, analyses were repeated for multiple realizations of system properties. Rankings of observation worth were similar for all realizations, indicating robust performance of the methodology when employed in conjunction with a highly nonlinear model. The analysis showed that while concentration and temperature measurements can both aid in the prediction of interface movement, concentration measurements, especially when taken in proximity to the interface at locations where the interface is expected to move, are of greater worth than temperature measurements. Nevertheless, it was also demonstrated that pairs of temperature measurements, taken in strategic locations with respect to the interface, can also lead to more precise predictions of interface movement. Journal compilation ?? 2010 National Ground Water Association.

  9. Estimation of irradiated control rod worth

    Energy Technology Data Exchange (ETDEWEB)

    Varvayanni, M., E-mail: melina@ipta.demokritos.g [NCSR ' DEMOKRITOS' , PO Box 60228, 15310 Aghia Paraskevi (Greece); Catsaros, N. [NCSR ' DEMOKRITOS' , PO Box 60228, 15310 Aghia Paraskevi (Greece); Antonopoulos-Domis, M. [School of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki (Greece)

    2009-11-15

    When depleted control rods are planned to be used in new core configurations, their worth has to be accurately predicted in order to deduce key design and safety parameters such as the available shutdown margin. In this work a methodology is suggested for the derivation of the distributed absorbing capacity of a depleted rod, useful in the case that the level of detail that is known about the irradiation history of the control rod does not allow an accurate calculation of the absorber's burnup. The suggested methodology is based on measurements of the rod's worth carried out in the former core configuration and on corresponding calculations based on the original (before first irradiation) absorber concentration. The methodology is formulated for the general case of the multi-group theory; it is successfully tested for the one-group approximation, for a depleted control rod of the Greek Research Reactor, containing five neutron absorbers. The computations reproduce satisfactorily the irradiated rod worth measurements, practically eliminating the discrepancy of the total rod worth, compared to the computations based on the nominal absorber densities.

  10. 基于改进的FP-tree的频繁模式挖掘算法%Frequent pattern mining algorithm based on improved FP-tree

    Institute of Scientific and Technical Information of China (English)

    李也白; 唐辉; 张淳; 贺玉明

    2011-01-01

    FP-growth is an efficient frequent pattern mining algorithm based on the data structure of FP-tree, which does not generate candidate sets. Constructing frequent pattern tree TP-tree requires to scanning data twice. What's more,transactions which only contain non-frequent items are also scanned during the second scanning. In order to solve this problem, after analyzing particularity of FP-tree deeply, this paper improved construction process of FP-tree and employed an auxiliary storage structure that bases on hash table, which saves time of searching items and enhances mining efficiency.%FP-growth算法是一种基于FP-tree数据结构的高效的频繁模式挖掘算法,它不产生候选集.构造频繁模式树FP-tree需扫描数据库两次,在第二遍扫描中还扫描了那些仅包含了非频繁项的事务,针对此问题,在深入分析了FP-tree特性的基础上,改进了FP-tree构造过程,同时用一种基于Hash表的辅助存储结构,节省了项目查找时间,提高了挖掘效率.

  11. Bibliometric performance analysis of publications from Danish researchers linked to FP6 and FP7

    DEFF Research Database (Denmark)

    Schneider, Jesper Wiborg; Ryan, Thomas Kjeldager

    2015-01-01

    citations belonging to scientific publications with at least one Danish author. This is done using data from the international citation database Web of Science (WoS). These results are compared to the results of the bibliometric analyses from the previous evaluations of the Danish National Research...

  12. 12 CFR 747.607 - Statement of net worth.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Statement of net worth. 747.607 Section 747.607... Justice Act in NCUA Board Adjudications § 747.607 Statement of net worth. (a) Each applicant (other than a... net worth of the applicant and any affiliates, as defined in § 747.602(a), when the proceeding...

  13. Capitalizing Central Banks: A Net Worth Approach

    OpenAIRE

    Alain Ize

    2005-01-01

    This paper provides a simple, quantitative, net worth-based, approach to assessing the need for central bank capital. It derives a concept of "core capital" (a function of the central bank's operating expenditures and the carrying cost of its international reserves) as the minimum capital needed by a central bank to ensure the credibility of its inflation target. The approach is illustrated with the published accounts of three loss-making central banks and selected accounting entries for a br...

  14. Challenges in Implementing FP7 Projects in the Public Institutions

    Directory of Open Access Journals (Sweden)

    Viorel VULTURESCU

    2012-06-01

    Full Text Available National Authority for Scientific Research (ANCS and Executive Unit for Higher Education, Research and Development and Innovation Funding (UEFISCDI participate to several projects funded under the Framework Programmes, since 1998. The staff from each the two organisations participating in projects are merely the same, typically from “international cooperation” departments. In each of the two organisations, dedicated teams were set and a distinct specialization emerged. In this respect, dedicated procedures and good practices in project management were developed. Even the Framework Programs had different structures and the focused was different (e.g. knowledge creation, EU problem solving, scientific support for policies and programs, etc., the funding instruments (projects were not radically different from a Framework Program to another, so the staff could gain experience in managing this type of projects. Experience and expertise gained during this long period of time led to definition of a general framework within the two institutions and setting up of a general guideline for participation to this type of projects. The main dimensions of this framework are: project team organization, project management process, managing results and risk, organisational framework, good practices, factors which ensure success in project implementation.The paper presents a specific framework for FP 7 project implementation and how this framework is applied by both organisations, a set of rules and procedures that should be followed by any organisation, in particular governmental ones, participating in FP 7 projects and a set of good practices developed by ANCS and UEFISCDI.

  15. Efficient Incremental Maintenance of Frequent Patterns with FP-Tree

    Institute of Scientific and Technical Information of China (English)

    Xiu-Li Ma; Yun-Hai Tong; Shi-Wei Tang; Dong-Qing Yang

    2004-01-01

    Mining frequent patterns has been studied popularly in data mining area. However, little work has been done on mining patterns when the database has an influx of fresh data constantly. In these dynamic scenarios, efficient maintenance of the discovered patterns is crucial. Most existing methods need to scan the entire database repeatedly, which is an obvious disadvantage. In this paper, an efficient incremental mining algorithm, Incremental-Mining (IM), is proposed for maintenance of the frequent patterns when new incremental data come. Based on the frequent pattern tree (FP-tree) structure, IM gives a way to make the most of the things from the previous mining process, and requires scanning the original data once at most. Furthermore, IM can identify directly the differential set of frequent patterns, which may be more informative to users. Moreover, IM can deal with changing thresholds as well as changing data, thus provide a full maintenance scheme. IM has been implemented and the performance study shows it outperforms three other incremental algorithms: FUP, DB-tree and re-running frequent pattern growth (FP-growth).

  16. Enhancing Moral Conformity and Enhancing Moral Worth.

    Science.gov (United States)

    Douglas, Thomas

    2014-01-01

    It is plausible that we have moral reasons to become better at conforming to our moral reasons. However, it is not always clear what means to greater moral conformity we should adopt. John Harris has recently argued that we have reason to adopt traditional, deliberative means in preference to means that alter our affective or conative states directly-that is, without engaging our deliberative faculties. One of Harris' concerns about direct means is that they would produce only a superficial kind of moral improvement. Though they might increase our moral conformity, there is some deeper kind of moral improvement that they would fail to produce, or would produce to a lesser degree than more traditional means. I consider whether this concern might be justified by appeal to the concept of moral worth. I assess three attempts to show that, even where they were equally effective at increasing one's moral conformity, direct interventions would be less conducive to moral worth than typical deliberative alternatives. Each of these attempts is inspired by Kant's views on moral worth. Each, I argue, fails.

  17. COST-WORTH ASSESSMENT OF AUTOMATED RADIAL DISTRIBUTION SYSTEM BASED ON RELIABILITY

    Directory of Open Access Journals (Sweden)

    E. Vidya Sagar

    2010-11-01

    Full Text Available Power reliability and quality are gaining their greater grounds than ever in the power and industrial market of the times. It has become an essential means for the successful dispatch of quality product, operation, services of any industry. The reliability of power distribution network can be greatly enhanced by the automation of its feeder system and other associated parts. Remotely controlled and automated restoration services can avoid the necessity of executing manual switching schedules and are bound to bring about remarkable levels of system reliability and interruption costs. The reliability cost-worth analysis is the excellent tool for evaluation of interruption costs. Reliability cost-worth analysis is very significant in the power system planning, operation, maintenance andexpansion, for it takes into account the customer concerns in the analysis. This paper deals in due detail with the reliability based cost-worth analysis of automated radial distribution network. The direct method of assessing the worth of reliability is to calculate the user costs relevant to interruptions in the power supply. By the application of failure mode effect analysis and cost-worth analysis byusing direct costing method the reliability of radial distribution network can be evaluated. The customer interruption costs’ indices of a radial distribution network calculated using the analytical method applied to an Indian utility network system with 2000KVA& sixteen nodes and the related results of the study are duly discussed in this paper.

  18. Mining φ-Frequent Itemset Using FP-Tree

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The problem of association rule mining has gained considerableprominence in the data mining community for its use as an important tool of knowledge discovery from large-scale databases. And there has been a spurt of research activities around this problem. However, traditional association rule mining may often derive many rules in which people are uninterested. This paper reports a generalization of association rule mining called φ-association rule mining. It allows people to have different interests on different itemsets that are the need of real application. Also, it can help to derive interesting rules and substantially reduce the amount of rules. An algorithm based on FP-tree for mining φ-frequent itemset is presented. It is shown by experiments that the proposed method is efficient and scalable over large databases.

  19. Transduction of plasmid DNA in Streptomyces spp. and related genera by bacteriophage FP43.

    Science.gov (United States)

    McHenney, M A; Baltz, R H

    1988-05-01

    A segment (hft) of bacteriophage FP43 DNA cloned into plasmid pIJ702 mediated high-frequency transduction of the resulting plasmid (pRHB101) by FP43 in Streptomyces griseofuscus. The transducing particles contained linear concatemers of plasmid DNA. Lysates of FP43 prepared on S. griseofuscus containing pRHB101 also transduced many other Streptomyces species, including several that restrict plaque formation by FP43 and at least two that produce restriction endonucleases that cut pRHB101 DNA. Transduction efficiencies in different species were influenced by the addition of anti-FP43 antiserum to the transduction plates, the temperature for cell growth before transduction, the multiplicity of infection, and the host on which the transducing lysate was prepared. FP43 lysates prepared on S. griseofuscus(pRHB101) also transduced species of Streptoverticillium, Chainia, and Saccharopolyspora.

  20. Baculovirus FP25K Localization: Role of the Coiled-Coil Domain.

    Science.gov (United States)

    Garretson, Tyler A; McCoy, Jason C; Cheng, Xiao-Wen

    2016-11-01

    Two types of viruses are produced during the baculovirus life cycle: budded virus (BV) and occlusion-derived virus (ODV). A particular baculovirus protein, FP25K, is involved in the switch from BV to ODV production. Previously, FP25K from the model alphabaculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) was shown to traffic ODV envelope proteins. However, FP25K localization and the domains involved are inconclusive. Here we used a quantitative approach to study FP25K subcellular localization during infection using an AcMNPV bacmid virus that produces a functional AcMNPV FP25K-green fluorescent protein (GFP) fusion protein. During cell infection, FP25K-GFP localized primarily to the cytoplasm, particularly amorphous structures, with a small fraction being localized in the nucleus. To investigate the sequences involved in FP25K localization, an alignment of baculovirus FP25K sequences revealed that the N-terminal putative coiled-coil domain is present in all alphabaculoviruses but absent in betabaculoviruses. Structural prediction indicated a strong relatedness of AcMNPV FP25K to long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p), which contains an N-terminal coiled-coil domain responsible for cytoplasmic retention. Point mutations and deletions of this domain lead to a change in AcMNPV FP25K localization from cytoplasmic to nuclear. The coiled-coil and C-terminal deletion viruses increased BV production. Furthermore, a betabaculovirus FP25K protein lacking this N-terminal coiled-coil domain localized predominantly to the nucleus and exhibited increased BV production. These data suggest that the acquisition of this N-terminal coiled-coil domain in FP25K is important for the evolution of alphabaculoviruses. Moreover, with the divergence of preocclusion nuclear membrane breakdown in betabaculoviruses and membrane integrity in alphabaculoviruses, this domain represents an alphabaculovirus adaptation for nuclear trafficking

  1. Biodiversity monitoring in Europe: the EU FP7 EBONE project. European biodiversity observation NEtwork

    CSIR Research Space (South Africa)

    Lück-Vogel, Melanie

    2008-09-01

    Full Text Available submission Presentation Poster presentation A) Title Biodiversity Monitoring in Europe: The EU FP7 EBONE project European Biodiversity Observation NEtwork B) Short title EBONE - European Biodiversity Observation NEtwork C) Author(s) Vogel, M. (1..., South Africa F) Biodiversity Monitoring in Europe: The EU FP7 EBONE project European Biodiversity Observation NEtwork On April 1st, 2008 the EU FP7 project EBONE (http://www.ebone.wur.nl/) was launched. The aim of the project...

  2. New Astrophysical Reaction Rates for 18F(p, α)15O and 18F(p, γ)19Ne

    Institute of Scientific and Technical Information of China (English)

    SHU Neng-Chuan(舒能川); D. W. Bardayan; J. C. Blackmon; CHEN Yong-Shou(陈永寿); R. L. Kozub; P. D. Parker; M. S. Smith

    2003-01-01

    The rates of the thermonuclear 18F(p, α)15O and 18F(p,γ)19Ne reactions in hot astrophysical environments are needed to understand gamma-ray emission from nova explosions. The rates for these reactions have been uncertain due to discrepancies in recent measurements, as well as to a lack of a comprehensive examination of the available structure information in the compound nucleus 19Ne. We have examined the latest experimental measurements with radioactive and stable beams, and made estimates of the unmeasured 19Ne nuclear level parameters, to generate new rates with uncertainties for these reactions. The rates are expressed as numerical values over the temperature range relevant for stellar explosions, as well as analytical expressions as functions of temperature in a format suitable for use in astrophysical simulations. Comparisons with the previous rate calculations are carried out, and the astrophysical implications are briefly discussed.

  3. 29 CFR 4062.4 - Determinations of net worth and collective net worth.

    Science.gov (United States)

    2010-07-01

    ... to sell, or offer to purchase or sell the business of the person made on or about the net worth record date. (2) A bona fide sale of, agreement to sell, or offer to purchase or sell stock or a...) The person's economic outlook, as reflected by its earnings and dividend projections,...

  4. 75 FR 48411 - Noise Compatibility Program Notice; Fort Worth Alliance Airport, Fort Worth, TX

    Science.gov (United States)

    2010-08-10

    ... Federal Aviation Administration Noise Compatibility Program Notice; Fort Worth Alliance Airport, Fort... Administration (FAA) announces that it is reviewing a proposed noise compatibility program that was submitted for... Noise Abatement Act, hereinafter referred to as ``the Act'') and 14 CFR Part 150 by the city of...

  5. A Spectrum is Worth a Thousand Pictures

    Science.gov (United States)

    Gelderman, Richard F.

    2006-12-01

    A wise astronomer once pointed out that if a picture is worth a thousand words, then a spectrum is worth a thousand pictures. Unfortunately, spectra are rarely emphasized in the introductory astronomy courses and few students exit such a course with any meaningful understanding or appreciation of spectroscopy. Part of the problem is lack of background knowledge; the typical introductory astronomy student has little experience with spectroscopy or atomic physics. Another issue is that spectra are not pretty pictures and are not intuitively understandable. We present and discuss a series of “minds-on” exercises and activities built into a college-level “stars, galaxies, and cosmology” intro astronomy course. The lessons are structured to help students improve their ability to recognize patterns and improve their ability to really see the details in front of them. Another goal is for students to realize there is “more than meets the eye” to learn how to discover “hidden” diagnostics, such as different sources of light their eyes see as white light. A curriculum that emphasizes spectroscopy also provides the opportunity to stress the story of the “Harvard Women,” a tale that bridges gender gaps and often humanizes scientists in the eyes of non-science majors. Finally, with a solid foundation in spectroscopy, students are better prepared to understand exciting topics such as Hubble’s Law and the importance of primordial nucleosynthesis.

  6. The Relationship of Coping, Self-Worth, and Subjective Well-Being: A Structural Equation Model

    Science.gov (United States)

    Smedema, Susan Miller; Catalano, Denise; Ebener, Deborah J.

    2010-01-01

    The purpose of this study was to determine the relationship between various coping-related variables and the evaluation of self-worth and subjective well-being among persons with spinal cord injury. Positive coping variables included hope, proactive coping style, and sense of humor, whereas negative coping variables included perceptions of stress,…

  7. Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings

    DEFF Research Database (Denmark)

    Buchert, Ralph; Kluge, Andreas; Tossici-Bolt, Livia

    2016-01-01

    reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [(123)I]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis. METHODS: Of 73 healthy subjects from the European Normal Control Database...... of [(123)I]FP-CIT recruited at six centres, 70 aged between 20 and 82 years were included. SPECT images were reconstructed using the QSPECT software package which provides fully automated detection of the outer contour of the head, camera-specific correction for scatter and septal penetration...... by transmission-dependent convolution subtraction, iterative OSEM reconstruction including attenuation correction, and camera-specific "to kBq/ml" calibration. LINK and HERMES reconstruction were used for head-to-head comparison. The specific striatal [(123)I]FP-CIT binding ratio (SBR) was computed using...

  8. Synthesis of Air-Stable Cyclopentadienyl Fe(CO)2 (Fp) Polymers by a Host-Guest Interaction of Cyclodextrin with Air-Sensitive Fp Pendant Groups.

    Science.gov (United States)

    Zhou, Na; Peng, Liao; Salgado, Shehan; Yuan, Jinying; Wang, Xiaosong

    2017-03-13

    Host-guest chemistry is used to address the challenge of the synthesis of air-stable polymers containing air-sensitive metal complexes. The complexation of the CpFe(CO)2 (Fp) pendent group with cyclodextrin (CD) molecules created air-stable poly(Fp-methylstyrene) P(CD/FpMSt). This CD complexation resulted in dimerization of the adjacent Fp groups, which was characterized by NMR, FTIR, and cyclic voltammetry (CV) analyses. P(CD/FpMSt) was soluble in DMSO and remained stable even the solution was exposed to air for months. The host-guest chemistry accounted for the improved stability, because the Fp groups decomposed upon removal of the CD molecules using competing guest molecules. The CD-complexed polymer showed light-trigged properties, including CO release and antimicrobial activity. Host-guest chemistry of air-sensitive organometallic complexes is therefore a promising technique that can be used to broaden the scope of metal-containing polymers (MCPs) with processable novel functions.

  9. Increased brain temserotoneric transporter availability in adult migraineurs: ([18F]FP-CIT PET imaging pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Park, Eun Kyung [Dept. of Nuclear Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul (Korea, Republic of); Hwang, Yu Mi [Center for Research Information, Korea University, Seoul (Korea, Republic of); Chu, Min Kyung [Dept. of Neurology, Sacred Heart Hospital, Hallym University College of Medicine, Anyang (Korea, Republic of); Jung, Ki Young [Dept. of Neurology, Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2016-03-15

    Recent studies have proposed central serotonergic dysfunction as a major pathophysiology of migraine. We investigated serotonin transporter (SERT) availability in migraineurs using F-18-N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([18F]FP-CIT) positron emission tomography (PET). Brain [18F]FP-CIT PET images were obtained in eight women with migraine during headache free phase and 12 healthy adult women, 120 min after injection of 185 MBq. Non-displaceable binding potential (BP ND) of [18F]FP-CIT, which is an estimate of SERT availability, was calculated at the brainstem and compared with clinical parameters. BP ND at the brainstem was significantly higher in adult migraineurs (n = 6, 1.15 ± 0.17) than healthy subjects (0.95 ± 0.14) (p = 0.04). Healthy subjects demonstrated negative correlation between brainstem BP ND and age (r = −0.64, p = 0.02), whereas this age-related decline pattern was not found in the migraineurs. Severity of migraine attack was significantly correlated with brainstem BP ND (r = 0.66, p = 0.02), when age and duration of illness were corrected. Increased SERT availability in the brainstem of adult migraineurs indicates low serotonin neurotransmission during headache-free phase. Patients who experience more painful headaches have lower serotonin neurotransmission. [18F]FP-CIT PET is a useful in vivo imaging technique for evaluating brainstem SERT availability in migraineurs.

  10. ASASSN-17fp rebrightening event and ongoing monitoring

    Science.gov (United States)

    Waagen, Elizabeth O.

    2017-05-01

    ASASSN-17fp, discovered on 2017 April 28 and classified as a helium dwarf nova, was observed to be in outburst again on May 16 after fading 2.5 magnitudes from its original outburst. Dr. Tom Marsh (University of Warwick) and Dr. Elme Breedt (University of Cambridge) requested immediate time-series coverage. Dr. Breedt wrote: "The transient was identified as a helium dwarf nova (also known as an AMCVn star) from a spectrum taken by the PESSTO survey and reported in ATel #10334. Since then, we have been observing the target using the New Technology Telescope on La Silla in Chile. We measured a photometric period of 51 minutes in the first few nights during which the object was bright at g=16.03 (Marsh et al., ATel #10354), and then it faded to about g 18. However last night [ May 16] it brightened back to g 16 again, apparently starting a second outburst. Time series observations during this bright state would be very valuable to determine whether the 51 min period we saw in earlier data returns, and whether it is the orbital period of the binary or related to the distortion of the accretion disc in outburst (superhumps). If the 51 min signal is the orbital period or close to it, this would be the helium dwarf nova with the longest orbital period known. Multiple successive outbursts are not uncommon in binaries like this..." Observers should continue to monitor ASASSN-17fp with nightly snapshots for two weeks after it fades, in case it rebrightens again. It appears to have faded, according to an observation in the AAVSO International Database by F.-J. Hambsch (HMB, Mol, Belgium), who observed it remotely from Chile on 2017 May 24.2252 UT at magnitude 19.944 CV ± 0.595. Continue nightly snapshots through June 6 at least, and if it brightens again, resume time series. Finder charts with sequence may be created using the AAVSO Variable Star Plotter (https://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Databa! se. See full Alert Notice

  11. Research of Improved FP-Growth Algorithm in Association Rules Mining

    Directory of Open Access Journals (Sweden)

    Yi Zeng

    2015-01-01

    with FP-Growth algorithm. Experimental results show that Painting-Growth algorithm is more than 1050 and N Painting-Growth algorithm is less than 10000 in data volume; the performance of the two kinds of improved algorithms is better than that of FP-Growth algorithm.

  12. Current Situations of the Integration of RTIs Prevention and Treatment into Routine FP Program

    Institute of Scientific and Technical Information of China (English)

    Li-xia DOU; Wei YUAN; Meng-ye PENG; Er-sheng GAO

    2007-01-01

    Objective To understand the current situation of the integration of reproductive tract infections (RTIs) prevention and treatment into routine Family planning (FP) program. Methods Literature review, in depth interview and focus group discussion were employed to collect the related information. Questionnaire survey was conducted in 59 county level FP facilities. Results Both central and local governments provide policy supports to RTIs prevention and treatment. Nearly 98.3% of local FP facilities had integrated this work into their routine FP program. A comprehensive network system of family planning has been established in China and there were plenty of FP human resources. The existing FP resource should be effectively used, which could produce great social benefit if RTIs prevention and treatment be integrated into routine FP program. However, some problems still need to be solved in the integrated program, such as insufficient finance support, low quality of service, lack of co-operations between different sectors, etc. Conclusion It is possible and feasible to develop RTIs controlling projects in the family planning system. However, intensive training and close co-operation need to be applied respectively into FP staffs and relative departments.

  13. Gaseous decontamination for major cp, fp and tru

    Energy Technology Data Exchange (ETDEWEB)

    Tatenuma, K.; Hishinuma, T.; Isoyama, N.; Noguchi, T. [Kaken Co. Mito-Institute, Ibaraki (Japan); Suzuki, M. [Tokyo Institute of Technology, Tokyo (Japan)

    1999-07-01

    As an effective decontamination based on dry-base treatment, we have developed two types practical gaseous decontamination technologies, one is based on carbonylation and fluorination reactions using several types of chemically reactive plasmas which have the performances and high efficiencies to decontaminate simultaneously the contaminants of major CP, FP and TRU, and another is based on fluorination reaction using fluoric reagent (i e., ClF{sub 3}, BrF{sub 5}, IF{sub 7}, etc.) to decontaminate the contaminants of major F P and TRU. In this study, it was verified that all of the chemically reactive plasmas of five types, which are electron cyclotron resonance, direct current, radio frequency, down stream micro wave and corona discharge, have high decontamination efficiencies of {sup 60}Co and uranium, and on the other hand the result of highly reactive gas decontamination using ClF{sub 3} as fluoric reagent showed that the contaminants of UF{sub 6} centrifugal concentrator were mostly cleaned up to non-radioactive materials under the treatment conditions of ambient temperature, short time and reduced pressure. The developed gas-phase decontamination technology based on volumes of waste created each year or non-incinerable radioactive waste. (author)

  14. FP7 FUPOL PROJECT – INNOVATION IN POLICY SCIENCE

    Directory of Open Access Journals (Sweden)

    Egils Ginters

    2013-06-01

    Full Text Available Mathematically justified planning of policy is extremely important because any wrong decision can lead to serious consequences. It is no secret that mathematical modelling and other advanced analytical methods are rarely used for policy planning and decision impact forecasting because those require specific knowledge. The FP7 FUPOL project aims at a completely new approach to traditional policy analysis providing direct access for policy decision makers to domain uses cases modelling and verification on FUPOL Simulator and visualisation of the results in the form suitable for beneficiaries. Policy domain uses cases models are versatile, therefore architecture of the simulator must fit to the requirements of complexity and usability that determines involving heterogeneous agent-based and system dynamics simulation technologies and distributed simulation. The article deals with FUPOL approach in policy modelling and simulation, simulator designing, and sustainability assessment of provided technology. The FUPOL approach promotes simultaneously running of heterogeneous use case simulation models enhancing performance of simulation session. Belonging to open source spreads potential users’ network thus reducing errors in simulation and also in policy decision making. Web services SOA based architecture enhances integration with other decision making and service tools.

  15. Research Progress on F-P Interference—Based Fiber-Optic Sensors

    Science.gov (United States)

    Huang, Yi Wen; Tao, Jin; Huang, Xu Guang

    2016-01-01

    We review our works on Fabry-Perot (F-P) interferometric fiber-optic sensors with various applications. We give a general model of F-P interferometric optical fiber sensors including diffraction loss caused by the beam divergence and the Gouy phase shift. Based on different structures of an F-P cavity formed on the end of a single-mode fiber, the F-P interferometric optical sensor has been extended to measurements of the refractive index (RI) of liquids and solids, temperature as well as small displacement. The RI of liquids and solids can be obtained by monitoring the fringe contrast related to Fresnel reflections, while the ambient temperature and small displacement can be obtained by monitoring the wavelength shift of the interference fringes. The F-P interferometric fiber-optic sensors can be used for many scientific and technological applications. PMID:27598173

  16. Projection effects on the FP thickness: a Monte-Carlo exploration

    CERN Document Server

    Lanzoni, B

    2003-01-01

    We study the contribution of projection effects to the intrinsic thickness of the Fundamental Plane (FP) of elliptical galaxies. The Monte-Carlo mapping technique between model properties and observed quantities, introduced by Bertin, Ciotti, and Del Principe (2002), is extended to oblate, two-integrals galaxy models, with non-homologous density profiles, adjustable flattening, variable amount of ordered rotational support, and for which all the relevant projected dynamical quantities can be expressed in fully analytical way. In agreement with previous works, it is found that projection effects move models not exactly parallel to the edge-on FP, by an amount that can be as large as the observed FP thickness. The statistical contribution of projection effects to the FP thickness is however marginal, and the estimated physical FP rms thickness is ~90% of the observed one (when corrected for measurement errors).

  17. Research Progress on F-P Interference-Based Fiber-Optic Sensors.

    Science.gov (United States)

    Huang, Yi Wen; Tao, Jin; Huang, Xu Guang

    2016-01-01

    We review our works on Fabry-Perot (F-P) interferometric fiber-optic sensors with various applications. We give a general model of F-P interferometric optical fiber sensors including diffraction loss caused by the beam divergence and the Gouy phase shift. Based on different structures of an F-P cavity formed on the end of a single-mode fiber, the F-P interferometric optical sensor has been extended to measurements of the refractive index (RI) of liquids and solids, temperature as well as small displacement. The RI of liquids and solids can be obtained by monitoring the fringe contrast related to Fresnel reflections, while the ambient temperature and small displacement can be obtained by monitoring the wavelength shift of the interference fringes. The F-P interferometric fiber-optic sensors can be used for many scientific and technological applications.

  18. Dependence of control rod worth on fuel burnup

    Energy Technology Data Exchange (ETDEWEB)

    Savva, P., E-mail: savvapan@ipta.demokritos.g [NCSR ' DEMOKRITOS' , PoB 60228, 15310 Aghia Paraskevi (Greece); Varvayanni, M., E-mail: melina@ipta.demokritos.g [NCSR ' DEMOKRITOS' , PoB 60228, 15310 Aghia Paraskevi (Greece); Catsaros, N., E-mail: nicos@ipta.demokritos.g [NCSR ' DEMOKRITOS' , PoB 60228, 15310 Aghia Paraskevi (Greece)

    2011-02-15

    Research highlights: Diffusion and MC calculations for rod worth dependence on burnup and Xe in reactors. One-step rod withdrawal/insertion are used for rod worth estimation. The study showed that when Xe is present the rods worth is significantly reduced. Rod worth variation with burnup depends on rod position in core. Rod worth obtained with MC code is higher than that obtained from deterministic. - Abstract: One important parameter in the design and the analysis of a nuclear reactor core is the reactivity worth of the control rods, i.e. their efficiency to absorb excess reactivity. The control rod worth is affected by parameters such as the fuel burnup in the rod vicinity, the Xe concentration in the core, the operational time of the rod and its position in the core. In the present work, two different computational approaches, a deterministic and a stochastic one, were used for the determination of the rods worth dependence on the fuel burnup level and the Xe concentration level in a conceptual, symmetric reactor core, based on the MTR fuel assemblies used in the Greek Research Reactor (GRR-1). For the deterministic approach the neutronics code system composed by the SCALE modules NITAWL and XSDRN and the diffusion code CITATION was used, while for the stochastic one the Monte Carlo code TRIPOLI was applied. The study showed that when Xe is present in the core, the rods worth is significantly reduced, while the rod worth variation with increasing burnup depends on the rods position in the core grid. The rod worth obtained with the use of the Monte Carlo code is higher than the one obtained from the deterministic code.

  19. [{sup 123}]FP-CIT SPECT scans initially rated as normal became abnormal over time in patients with probable dementia with Lewy bodies

    Energy Technology Data Exchange (ETDEWEB)

    Zande, J.J. van der; Scheltens, P.; Lemstra, A.W. [VU Medical Center Alzheimer Center, Amsterdam (Netherlands); Booij, J. [Academic Medical Center, Department of Nuclear Medicine, Amsterdam (Netherlands); Raijmakers, P.G.H.M. [VU Medical Center, Department of Nuclear Medicine, Amsterdam (Netherlands)

    2016-06-15

    Decreased striatal dopamine transporter (DAT) binding on SPECT imaging is a strong biomarker for the diagnosis of dementia with Lewy bodies (DLB). There is still a lot of uncertainty about patients meeting the clinical criteria for probable DLB who have a normal DAT SPECT scan (DLB/S-). The aim of this study was to describe the clinical and imaging follow-up in these patients, and compare them to DLB patients with abnormal baseline scans (DLB/S+). DLB patients who underwent DAT imaging ([{sup 123}I]FP-CIT SPECT) were selected from the Amsterdam Dementia Cohort. All [{sup 123}I]FP-CIT SPECT scans were evaluated independently by two nuclear medicine physicians and in patients with normal scans follow-up imaging was obtained. We matched DLB/S- patients for age and disease duration to DLB/S+ patients and compared their clinical characteristics. Of 67 [{sup 123}I]FP-CIT SPECT scans, 7 (10.4 %) were rated as normal. In five DLB/S- patients, a second [{sup 123}I]FP-CIT SPECT was performed (after on average 1.5 years) and these scans were all abnormal. No significant differences in clinical characteristics were found at baseline. DLB/S- patients could be expected to have a better MMSE score after 1 year. This study was the first to investigate DLB patients with the initial [{sup 123}I]FP-CIT SPECT scan rated as normal and subsequent scans during disease progression rated as abnormal. We hypothesize that DLB/S- scans could represent a relatively rare DLB subtype with possibly a different severity or spread of alpha-synuclein pathology (''neocortical predominant subtype''). In clinical practice, if an alternative diagnosis is not imminent in a DLB/S- patient, repeating [{sup 123}I]FP-CIT SPECT should be considered. (orig.)

  20. Machine learning models for the differential diagnosis of vascular parkinsonism and Parkinson's disease using [{sup 123}I]FP-CIT SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Huertas-Fernandez, I.; Benitez-Rivero, S.; Jesus, S.; Caceres-Redondo, M.T.; Martin-Rodriguez, J.F.; Carrillo, F. [Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Unidad de Trastornos del Movimiento, Servicio de Neurologia y Neurofisiologia Clinica, Seville (Spain); Garcia-Gomez, F.J.; Marin-Oyaga, V.A.; Lojo, J.A. [Hospital Universitario Virgen del Rocio, Servicio de Medicina Nuclear, UDIM, Seville (Spain); Garcia-Solis, D. [Hospital Universitario Virgen del Rocio, Servicio de Medicina Nuclear, UDIM, Seville (Spain); Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Seville (Spain); Mir, P. [Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Unidad de Trastornos del Movimiento, Servicio de Neurologia y Neurofisiologia Clinica, Seville (Spain); Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Seville (Spain)

    2015-01-15

    The study's objective was to develop diagnostic predictive models using data from two commonly used [{sup 123}I]FP-CIT SPECT assessment methods: region-of-interest (ROI) analysis and whole-brain voxel-based analysis. We included retrospectively 80 patients with vascular parkinsonism (VP) and 164 patients with Parkinson's disease (PD) who underwent [{sup 123}I]FP-CIT SPECT. Nuclear-medicine specialists evaluated the scans and calculated bilateral caudate and putamen [{sup 123}I]FP-CIT uptake and asymmetry indices using BRASS software. Statistical parametric mapping (SPM) was used to compare the radioligand uptake between the two diseases at the voxel level. Quantitative data from these two methods, together with potential confounding factors for dopamine transporter availability (sex, age, disease duration and severity), were used to build predictive models following a tenfold cross-validation scheme. The performance of logistic regression (LR), linear discriminant analysis and support vector machine (SVM) algorithms for ROI data, and their penalized versions for SPM data (penalized LR, penalized discriminant analysis and SVM), were assessed. Significant differences were found in the ROI analysis after covariate correction between VP and PD patients in [{sup 123}I]FP-CIT uptake in the more affected side of the putamen and the ipsilateral caudate. Age, disease duration and severity were also found to be informative in feeding the statistical model. SPM localized significant reductions in [{sup 123}I]FP-CIT uptake in PD with respect to VP in two specular clusters comprising areas corresponding to the left and right striatum. The diagnostic predictive accuracy of the LR model using ROI data was 90.3 % and of the SVM model using SPM data was 90.4 %. The predictive models built with ROI data and SPM data from [{sup 123}I]FP-CIT SPECT provide great discrimination accuracy between VP and PD. External validation of these methods is necessary to confirm their

  1. 38 CFR 3.263 - Corpus of estate; net worth.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Corpus of estate; net....263 Corpus of estate; net worth. (a) General. The following rules are for application in determining the corpus of estate of a parent where dependency is a factor under § 3.250, and the net worth of...

  2. 7 CFR 1427.1083 - Bonding requirements for net worth.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Bonding requirements for net worth. 1427.1083 Section 1427.1083 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT... Warehouses for Cotton and Cotton Linters § 1427.1083 Bonding requirements for net worth. A bond furnished...

  3. Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer.

    Science.gov (United States)

    Harding, Thomas C; Long, Li; Palencia, Servando; Zhang, Hongbing; Sadra, Ali; Hestir, Kevin; Patil, Namrata; Levin, Anita; Hsu, Amy W; Charych, Deborah; Brennan, Thomas; Zanghi, James; Halenbeck, Robert; Marshall, Shannon A; Qin, Minmin; Doberstein, Stephen K; Hollenbaugh, Diane; Kavanaugh, W Michael; Williams, Lewis T; Baker, Kevin P

    2013-03-27

    The fibroblast growth factor (FGF) pathway promotes tumor growth and angiogenesis in many solid tumors. Although there has long been interest in FGF pathway inhibitors, development has been complicated: An effective FGF inhibitor must block the activity of multiple mitogenic FGF ligands but must spare the metabolic hormone FGFs (FGF-19, FGF-21, and FGF-23) to avoid unacceptable toxicity. To achieve these design requirements, we engineered a soluble FGF receptor 1 Fc fusion protein, FP-1039. FP-1039 binds tightly to all of the mitogenic FGF ligands, inhibits FGF-stimulated cell proliferation in vitro, blocks FGF- and vascular endothelial growth factor (VEGF)-induced angiogenesis in vivo, and inhibits in vivo growth of a broad range of tumor types. FP-1039 antitumor response is positively correlated with RNA levels of FGF2, FGF18, FGFR1c, FGFR3c, and ETV4; models with genetic aberrations in the FGF pathway, including FGFR1-amplified lung cancer and FGFR2-mutated endometrial cancer, are particularly sensitive to FP-1039-mediated tumor inhibition. FP-1039 does not appreciably bind the hormonal FGFs, because these ligands require a cell surface co-receptor, klotho or β-klotho, for high-affinity binding and signaling. Serum calcium and phosphate levels, which are regulated by FGF-23, are not altered by administration of FP-1039. By selectively blocking nonhormonal FGFs, FP-1039 treatment confers antitumor efficacy without the toxicities associated with other FGF pathway inhibitors.

  4. Structural characterization of IrisFP, an optical highlighter undergoing multiple photo-induced transformations.

    Science.gov (United States)

    Adam, Virgile; Lelimousin, Mickaël; Boehme, Susan; Desfonds, Guillaume; Nienhaus, Karin; Field, Martin J; Wiedenmann, Joerg; McSweeney, Sean; Nienhaus, G Ulrich; Bourgeois, Dominique

    2008-11-25

    Photoactivatable fluorescent proteins (FPs) are powerful fluorescent highlighters in live cell imaging and offer perspectives for optical nanoscopy and the development of biophotonic devices. Two types of photoactivation are currently being distinguished, reversible photoswitching between fluorescent and nonfluorescent forms and irreversible photoconversion. Here, we have combined crystallography and (in crystallo) spectroscopy to characterize the Phe-173-Ser mutant of the tetrameric variant of EosFP, named IrisFP, which incorporates both types of phototransformations. In its green fluorescent state, IrisFP displays reversible photoswitching, which involves cis-trans isomerization of the chromophore. Like its parent protein EosFP, IrisFP also photoconverts irreversibly to a red-emitting state under violet light because of an extension of the conjugated pi-electron system of the chromophore, accompanied by a cleavage of the polypeptide backbone. The red form of IrisFP exhibits a second reversible photoswitching process, which may also involve cis-trans isomerization of the chromophore. Therefore, IrisFP displays altogether 3 distinct photoactivation processes. The possibility to engineer and precisely control multiple phototransformations in photoactivatable FPs offers exciting perspectives for the extension of the fluorescent protein toolkit.

  5. Multiwavelength narrow linewidth erbium-doped fiber laser based on FP-LDs.

    Science.gov (United States)

    Zhang, Aiqin; Jin, Yanbing; Feng, Xinhuan; Zhou, Jingjuan; Li, Zhaohui; Guan, Bai-Ou

    2013-07-15

    In this paper, we propose and demonstrate a technique to realize multiwavelength operation in erbium-doped fiber lasers (EDFLs) by inserting two Fabry Pérot laser diodes (FP-LDs) in the laser cavity respectively in cascaded and parallel way. The FP-LDs not only act as wavelength selection elements, but also offer optical gain or loss for the operation wavelengths in the laser cavity. The gains or losses for the oscillation wavelengths obtained from FP-LDs differ with adjustment of the driving current of the FP-LDs. Thus, the utilization of the FP-LDs in the laser cavity can introduce wavelength dependent gain or loss which can effectively suppress the competition caused by the homogeneous gain broadening of the erbium-doped fiber (EDF). As a result, 16-wavelength and 20-wavelength operation with a wavelength-spacing of 1.25 nm has been achieved respectively in the cascaded and parallel FP-LDs based EDFL schemes. The measured power fluctuation of each wavelength is smaller than 0.4dB for both EDFLs. Furthermore, the injection locking of the FP-LDs ensures a narrow linewidth of the EDFL output and the linewidth is estimated to be narrower than 100 MHz for the cascaded scheme based EDFL.

  6. Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficient mice.

    Science.gov (United States)

    Kawamata, Masaki; Yoshida, Masahide; Sugimoto, Yukihiko; Kimura, Tadashi; Tonomura, Yutaka; Takayanagi, Yuki; Yanagisawa, Teruyuki; Nishimori, Katsuhiko

    2008-02-13

    The dramatic increase of oxytocin (OT) receptor (OTR) in the myometrium as well as circulating progesterone withdrawal has been thought to be the most important factor in the induction and accomplishment of parturition since delivery fails in prostaglandin F2alpha receptor (FP) knockout (FP KO) mice. The expression levels of OTR mRNA/protein were not dramatically increased in the near-term uteri of FP KO mice. However, OT-induced myometrial contractions and the concentration-response curves in FP KO in vitro were almost similar to those in wild-type (WT) mice. OT-infusion (0.3 U/day) enabled FP KO mice to experience successful delivery, and furthermore the duration until the onset was hastened by a higher dose of OT (3 U/day). The plasma progesterone levels of FP KO females were maintained at high levels, but decreased during labor by OT-infusion (3 U/day). These results suggest that OT has potentials to induce strong myometrial contractions in uterus with low expression levels of OTR and luteolysis in ovary, which enabled FP KO females to undergo successful delivery.

  7. Blackness coefficients, effective diffusion parameters, and control rod worths for thermal reactors

    Energy Technology Data Exchange (ETDEWEB)

    Bretscher, M.M.

    1984-09-01

    Simple diffusion theory cannot be used to evaluate control rod worths in thermal reactors because of the strongly absorbing character of the control material. However, good results can be obtained from a diffusion calculation by representing the absorber slab by means of a suitable pair of internal boundary conditions, ..cap alpha.. and ..beta.., which are ratios of neutron flux to neutron current. Methods for calculating ..cap alpha.. and ..beta.. in the P/sub 1/, P/sub 3/, and P/sub 5/ approximations, with and without scattering, are presented. By appropriately weighting the fine-group blackness coefficients, broad group values, <..cap alpha..> and <..beta..>, are obtained. The technique is applied to the calculation of control rod worths of Cd, Ag-In-Cd, and Hf control elements. Results are found to compare very favorably with detailed Monte Carlo calculations. For control elements whose geometry does not permit a thin slab treatment, other methods are needed for determining the effective diffusion parameters. One such method is briefly discussed and applied to the calculation of control rod worths in the Ford Nuclear Reactor at the University of Michigan. Calculated and measured worths are found to be in good agreement.

  8. Something worth remembering: visual discrimination in sharks.

    Science.gov (United States)

    Fuss, Theodora; Schluessel, Vera

    2015-03-01

    This study investigated memory retention capabilities of juvenile gray bamboo sharks (Chiloscyllium griseum) using two-alternative forced-choice experiments. The sharks had previously been trained in a range of visual discrimination tasks, such as distinguishing between squares, triangles and lines, and their corresponding optical illusions (i.e., the Kanizsa figures or Müller-Lyer illusions), and in the present study, we tested them for memory retention. Despite the absence of reinforcement, sharks remembered the learned information for a period of up to 50 weeks, after which testing was terminated. In fish, as in other vertebrates, memory windows vary in duration depending on species and task; while it may seem beneficial to retain some information for a long time or even indefinitely, other information may be forgotten more easily to retain flexibility and save energy. The results of this study indicate that sharks are capable of long-term memory within the framework of selected cognitive skills. These could aid sharks in activities such as food retrieval, predator avoidance, mate choice or habitat selection and therefore be worth being remembered for extended periods of time. As in other cognitive tasks, intraspecific differences reflected the behavioral breadth of the species.

  9. Clinical features and {sup 123}I-FP-CIT SPECT imaging in drug-induced parkinsonism and Parkinson's disease

    Energy Technology Data Exchange (ETDEWEB)

    Diaz-Corrales, Francisco J.; Escobar-Delgado, Teresa [Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Unidad de Trastornos del Movimiento, Servicio de Neurologia, Instituto de Biomedicina de Sevilla, Seville (Spain); Sanz-Viedma, Salome [Hospital Universitario Virgen del Rocio, Unidad Diagnostica de Medicina Nuclear, Seville (Spain); Garcia-Solis, David [Hospital Universitario Virgen del Rocio, Unidad Diagnostica de Medicina Nuclear, Seville (Spain); Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Seville (Spain); Mir, Pablo [Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Unidad de Trastornos del Movimiento, Servicio de Neurologia, Instituto de Biomedicina de Sevilla, Seville (Spain); Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Seville (Spain); Hospital Universitario Virgen del Rocio, Unidad de Trastornos del Movimiento. Servicio de Neurologia, Seville (Spain)

    2010-03-15

    To determine clinical predictors and accuracy of {sup 123}I-FP-CIT SPECT imaging in the differentiation of drug-induced parkinsonism (DIP) and Parkinson's disease (PD). Several clinical features and {sup 123}I-FP-CIT SPECT images in 32 patients with DIP, 25 patients with PD unmasked by antidopaminergic drugs (PDu) and 22 patients with PD without a previous history of antidopaminergic treatment (PDc) were retrospectively evaluated. DIP and PD shared all clinical features except symmetry of parkinsonian signs which was more frequently observed in patients with DIP (46.9%) than in patients with PDu (16.0%, p<0.05) or PDc (4.5%, p<0.01). Qualitatively {sup 123}I-FP-CIT SPECT images were normal in 29 patients with DIP (90.6%) and abnormal in all patients with PD, and this imaging technique showed high levels of accuracy. DIP and PD are difficult to differentiate based on clinical signs. The precision of clinical diagnosis could be reliably enhanced by {sup 123}I-FP-CIT SPECT imaging. (orig.)

  10. Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB

    Science.gov (United States)

    Attems, Johannes; Colloby, Sean J.; O'Brien, John T.; McKeith, Ian; Walker, Rodney; Lee, Lean; Burn, David; Lett, Debra J.; Walker, Zuzana

    2017-01-01

    Objective: To conduct a validation study of 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. Methods: Patients >60 years of age with dementia who had undergone 123I-FP-CIT imaging in research studies and who had donated their brain tissue to the Newcastle Brain Tissue Resource were included. All had structured clinical research assessments, and clinical diagnoses were applied by consensus panels using international diagnostic criteria. All underwent 123I-FP-CIT imaging at baseline, and scans were rated as normal or abnormal by blinded raters. Patients were reviewed in prospective studies and after death underwent detailed autopsy assessment, and neuropathologic diagnoses were applied with the use of standard international criteria. Results: Fifty-five patients (33 with DLB and 22 with Alzheimer disease) were included. Against autopsy diagnosis, 123I-FP-CIT had a balanced diagnostic accuracy of 86% (sensitivity 80%, specificity 92%) compared with clinical diagnosis, which had an accuracy of 79% (sensitivity 87%, specificity 72%). Among patients with DLB, 10% (3 patients) met pathologic criteria for Lewy body disease but had normal 123I-FP-CIT imaging. Conclusions: This large autopsy analysis of 123I-FP-CIT imaging in dementia demonstrates that it is a valid and accurate biomarker for DLB, and the high specificity compared with clinical diagnosis (20% higher) is clinically important. The results need to be replicated with patients recruited from a wider range of settings, including movement disorder clinics and general practice. While an abnormal 123I-FP-CIT scan strongly supports Lewy body disease, a normal scan does not exclude DLB with minimal brainstem involvement. Classification of evidence: This study provides Class I evidence that 123I-FP-CIT dopaminergic neuroimaging accurately identifies patients with DLB

  11. FlowFP: A Bioconductor Package for Fingerprinting Flow Cytometric Data

    OpenAIRE

    Wade T. Rogers; Herbert A. Holyst

    2009-01-01

    A new software package called flowFP for the analysis of flow cytometry data is introduced. The package, which is tightly integrated with other Bioconductor software for analysis of flow cytometry, provides tools to transform raw flow cytometry data into a form suitable for direct input into conventional statistical analysis and empirical modeling software tools. The approach of flowFP is to generate a description of the multivariate probability distribution function of flow cytometry data i...

  12. Biohydrometallurgy applied to exploitation of black shale resources: Overview of Bioshale FP6 European project

    Institute of Scientific and Technical Information of China (English)

    P.D'HUGUES; P.SPOLAORE; Bioshale Consortium

    2008-01-01

    Bioshale project,co-funded by the European Commission (FP6 programme),started in October 2004 and finished in October 2007.The main objective of this project was to define innovative biotechnological processes for "eco-efficient" exploitation of black shale ores.The black shale ores contain base,precious and high-tech metals but also high contents of organic matter that handicap metal recovery by conventional techniques.Three world class black shale deposits were chosen as targets of the R&D actions.These include one deposit that existed under natural conditions (Talvivaara,Finland),one currently in process (Lubin,Poland) and one after mining (Mansfeld,Germany).The main technical aspects of the work plan can be summarized as follows:evaluation of the geological resources and selection of metal-bearing components; selection of biological consortia to be tested for metal recovery; assessment of bioprocessing routes,including hydrometallurgical processing for metals recovery; techno-economic evaluation of new processes including social and environmental impacts.An overview of the main results obtained by the 13 European partners (from 8 countries) involved in this completed research programme is given in this work.

  13. Preliminary results of the PREFER FP7 Project

    Science.gov (United States)

    Fusilli, Lorenzo; Laneve, Giovanni; De Bonis, Roberto; Sebastian, Ana; Ferrucci, Fabrizio; Oliveira, Sandra

    2014-05-01

    The need to improve the information and intelligence support for forest fire prevention is widely recognized. Fire prevention is still the most cost-effective strategy when compared to firefighting and extinguishing that are costly, local, and triggered only in response to already ongoing crises. PREFER project, funded under the EU FP7 (G.A. 312931), intends to contribute at responding to such a pragmatic need of southern Europe's forests by: providing timely information products based on the exploitation of all available spacecraft sensors, offering a portfolio of products focused on pre- and post-crisis forest fire emergency, suitable for the users in the different countries of the European Mediterranean area. The PREFER Service portfolio consists of two main services: 1. Information Support to Fire Preparedness/Prevention Phase" (ISP) Service 2. Information Support to Fire Recovery/Reconstruction Phase" (ISR) Service This service is already at an advanced stage having completed the first year of activity. During this time several products have been consolidated: seasonal fuel maps; daily and seasonal fire hazard maps; seasonal risk maps; prescribed fire maps. This paper aims at presenting the preliminary results of the research activity carried out in the framework of the PREFER project, focusing, in particular, on these recalled above. As for Fire Risk and Hazard assessment, many indexes have been developed in the last years. Hardly any of them uses data derived from satellite images. The FPI index is an exception to this rule which, in addition, makes use of meteorological data. In spite of being a very complete index, the FPI still allows room for improvement which justify the interest of PREFER in it. PREFER's innovative approach to FPI will allow taking into account the effect of solar illumination conditions in determining the humidity present in the dead vegetation, and therefore its proneness to burn. PREFER innovation also focus in allowing the index to

  14. Study: Colonoscopy After 75 May Not Be Worth It

    Science.gov (United States)

    ... Study: Colonoscopy After 75 May Not Be Worth It But, expert says age shouldn't be only ... and remove cancerous growths in the colon, but it may not provide much cancer prevention benefit after ...

  15. RadNet Air Data From Fort Worth, TX

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Fort Worth, TX from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  16. 40 CFR 17.12 - Net worth exhibit.

    Science.gov (United States)

    2010-07-01

    ... JUSTICE ACT IN EPA ADMINISTRATIVE PROCEEDINGS Information Required From Applicants § 17.12 Net worth exhibit. (a) Each applicant except a qualified tax exempt organization or a qualified cooperative...

  17. 7 CFR 1.191 - Net worth exhibit.

    Science.gov (United States)

    2010-01-01

    ... Equal Access to Justice Act in Proceedings Before the Department Information Required from Applicants § 1.191 Net worth exhibit. (a) An applicant, except a qualified tax-exempt organization or...

  18. 45 CFR 13.11 - Net worth exhibits.

    Science.gov (United States)

    2010-10-01

    ... TO JUSTICE ACT IN AGENCY PROCEEDINGS Information Required from Applicants § 13.11 Net worth exhibits... requirement does not apply to a qualified tax-exempt organization or cooperative association. Nor does...

  19. Differential Diagnosis of Patients with Inconclusive Parkinsonian Features Using [{sup 18}F]FP-CIT PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Park, Eunkyung; Hwang, Yu Mi; Lee, Channyoung; Oh, Sun Young; Kim, Young Chul; Choe, Jae Gol; Park, Kun Woo [Korea Univ., Seoul (Korea, Republic of); Kim, Sujin [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2014-06-15

    It is often difficult to differentiate parkinsonism, especially when patients show uncertain parkinsonian features. We investigated the usefulness of dopamine transporter (DAT) imaging for the differential diagnosis of inconclusive parkinsonism using [{sup 18}F]FP-CIT PET. Twenty-four patients with inconclusive parkinsonian features at initial clinical evaluation and nine healthy controls were studied. Patients consisted of three subgroups: nine patients whose diagnoses were unclear concerning whether they had idiopathic Parkinson's disease or drug-induced parkinsonism ('PD/DIP'), nine patients who fulfilled neither the diagnostic criteria of PD nor of essential tremor ('PD/ET'), and six patients who were alleged to have either PD or atypical parkinsonian syndrome ('PD/APS'). Brain PET images were obtained 120 min after injection of 185 MBq [{sup 18}F]FP-CIT. Imaging results were quantified and compared with follow-up clinical diagnoses. Overall, 11 of 24 patients demonstrated abnormally decreased DAT availability on the PET scans, whereas 13 were normal. PET results could diagnose PD/DIP and PD/ET patients as having PD in six patients, DIP in seven, and ET in five; however, the diagnoses of all six PD/APS patients remained inconclusive. Among 15 patients who obtained a final follow-up diagnosis, the image-based diagnosis was congruent with the follow-up diagnosis in 11 patients. Four unsolved cases had normal DAT availability, but clinically progressed to PD during the follow-up period. [{sup 18}F]FP-CIT PET imaging is useful in the differential diagnosis of patients with inconclusive parkinsonian features, except in patients who show atypical features or who eventually progress to PD.

  20. Health care, human worth and the limits of the particular.

    OpenAIRE

    1997-01-01

    An ethics concerned with health care developments and systems must be historically continuous, especially as it concerns the application to managed structures of key moral-epistemic concepts such as care, love and empathy. These concepts are traditionally most at home in the personal, individual domain. Human beings have non-instrumental worth just because they are human beings and not by virtue of their capacities. Managed health care systems tend to abstract from this worth in respect of bo...

  1. Modeling structure and spectra of the kindling fluorescent protein asFP595

    Science.gov (United States)

    Collins, Jack R.; Topol, Igor A.; Savitsky, Alexander P.; Nemukhin, Alexander V.

    2011-03-01

    Modern computational approaches based on quantum mechanical methods to characterize structures and optical spectra of biological chromophores in proteins are intensively used to gain knowledge of events occurring upon of their photoexcitation. Primary attention is paid to the species from the family of the green fluorescent protein applied as biomarkers in living cells. We apply quantum chemical approaches for accurate calculations of the structures of the chromophore binding pockets and to estimate spectral bands corresponding to the S0-S1 optical transitions of the intriguing kindling protein asFP595. Its precursor, the chromoprotein asCP from the sea anemony Anemonia sulcata is characterized by distinctive spectral properties: at low light intensities the wild-type protein is weakly fluorescent with the very low quantum yield, however, high intensity irradiation with green light leads to a drastic increase of quantum yield. This phenomenon is now termed "kindling". In simulations, the model system is designed as a molecular cluster constructed on the basis of available crystal structures of the related protein. The equilibrium geometry of the cluster is optimized using density functional theory approximations. The vertical excitation energies corresponding to the S0-S1 transitions are computed by using the semiempirical ZINDO technique. A special attention is paid to evaluate effects of point mutations in the vicinity of the chromophore group. Theoretical data provide important information on the chromophore properties aiming to interpret the results of experimental studies and applications of this fluorescent protein.

  2. Postoperative radiotherapy for lung cancer: Is it worth the controversy?

    Science.gov (United States)

    Billiet, Charlotte; Peeters, Stéphanie; Decaluwé, Herbert; Vansteenkiste, Johan; Mebis, Jeroen; Ruysscher, Dirk De

    2016-12-01

    The role of postoperative radiation therapy (PORT) in patients with completely resected non-small cell lung cancer (NSCLC) with pathologically involved mediastinal lymph nodes (N2) remains unclear. Despite a reduction of local recurrence (LR), its effect on overall survival (OS) remains unproven. Therefore we conducted a review of the current literature. To investigate the benefit and safety of modern PORT, we identified published phase III trials for PORT. We investigated modern PORT in low-risk (ypN0/1 and R0) and high-risk (ypN2 and/or R1/2) patients with stage III-N2 NSCLC treated with induction chemotherapy and resection. Seventeen phase III trials using PORT were selected. Of all PORT N2 studies, 4 were eligible for evaluation of LR, all in high-risk patients only. In these high-risk patients receiving PORT, the mean LR rate at 5years was 20.9% (95% CI 16-24). Two trials were suitable to assess LR rates after chemotherapy and surgery without PORT. In these low-risk patients, the mean 5-year LR was 33.1% (95% CI 27-39). No significant difference in non-cancer deaths between PORT vs. non-PORT patients was observed in N2 NSCLC. PORT is worth the controversy because data illustrate that PORT may increase the OS. However, prospective randomized trials are needed to verify this. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Matching intermediate-term, multi-angle averages of CIRS FP1+FP3 observations for the He VMR and cloud in Saturn’s atmosphere

    Science.gov (United States)

    Serrano, Joshua; Orton, Glenn S.; Sinclair, James; Fletcher, Leigh N.

    2017-01-01

    IntroductionSaturn’s atmosphere is a complicated system that is affected by many internal and external variables. To better understand these variables and how they affect Saturn’s atmospheric system we rely on data obtained from spacecraft and Earth based observatories. For this particular study, we used data from Cassini’s Composite Infrared Spectrometer (CIRS) instrument.Currently we do not know the exact amount of helium (He) with respect to molecular hydrogen gas (H2) in Saturn’s atmosphere. This He and H2 volume mixing ratio (VMR) is extremely important in understanding the structure and evolution of Saturn’s atmosphere. The CIRS team was not able to identify reliable matching spectra with data obtained from Focal Plane 1 (FP1) and Focal Plane 3 (FP3) of the CIRS instrument.MethodsAll the data sets we have worked with range from the years 2005-2012. Each year’s data sets were organized into 6 month intervals spanning the months January-June and July-December with data for FP1 and FP3 being completely separate. Each data set is also binned by planetographic latitude.Each data point consists of a spectra wavenumber, radiance value, and an emission angle. The emission angle is then converted to the unit μ, the value of this unit is simply the cosine of the emission angle. Initially all data was binned by year, latitude, and calculated µ value. This data was then plotted as a function of radiance and wavenumber to identify areas of spectral overlap data overlap in corresponding FP1 and FP3 data sets. These data sets were then prepped to be processed by a radiative transfer retrieval algorithm called NEMESIS.ResultsFurther binning of the data sets by looking at abundance of spectra values at certain μ values allows us to increase our confidence that these data sets are populated with enough spectra for NEMESIS to work with. NEMESIS has been operating with assumed He and H2 values derived from results of other studies, this means that narrowing down a

  4. Synthesis of β-CIT、β-FP-CIT and Its Precursor nor-β-CIT%β-CIT、β-FP-CIT及其前体nor-β-CIT的合成

    Institute of Scientific and Technical Information of China (English)

    唐刚华; 唐小兰

    2001-01-01

    2-β-甲酯基-3-β-(4-碘苯基)降托烷(nor-β-CIT)是多巴胺转运蛋白正电子显像剂[11C]-2-β-甲酯基-3-β-(4-碘苯基)托品烷([11C]-β-CIT)和[18F]-N-3-氟丙基-2-β-甲酯基-3-β-(4-碘苯基)降托烷([18F]-β-FP-CIT)的前体。本实验以可卡因为原料,经水解、脱水、酯化、格氏化、碘化、脱甲基等步骤合成了nor-β-CIT,总产率为12.9%,并以nor-β-CIT为原料合成了β-CIT和β-FP-CIT,为进一步放射化学合成[11C]-β-CIT和[18F]-β-FP-CIT提供了可靠的技术路线。%[11C]-2-β-Carbomethoxy-3-β-(4-iodophenyl)tropane([11C]-β-CIT)and [18F]-N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl)nortropane([18F]-β-FP-CIT)are the positron imaging agents as dopamine transporters,whose precursor is 2-β-carbomethoxy-3-β-(4-iodophenyl)nortropane(nor-β-CIT).The nor-β-CIT was synthesized from the cocaine as the starting material,which was based on hydrolysis,dehydration,esterification,Grignard reaction,iodination and demethylation,the total yield from the cocaine was 12.9%.The β-CIT was synthesized from the nor-β-CIT reaction with CH3I,and the β-FP-CIT synthesized from the nor-β-CIT reaction with FCH2CH2CH2Br.The study provided a practical method for radiochemical synthesis of [11C]-β-CIT and [18F]-β-FP-CIT.

  5. Blackness coefficients, effective diffusion parameters, and control rod worths for thermal reactors - methods

    Energy Technology Data Exchange (ETDEWEB)

    Bretscher, M.M.

    1984-01-01

    Simple diffusion theory cannot be used to evaluate control rod worths in thermal neutron reactors because of the strongly absorbing character of the control material. However, reliable control rod worths can be obtained within the framework of diffusion theory if the control material is characterized by a set of mesh-dependent effective diffusion parameters. For thin slab absorbers the effective diffusion parameters can be expressed as functions of a suitably-defined pair of blackness coefficients. Methods for calculating these blackness coefficients in the P/sub 1/, P/sub 3/, and P/sub 5/ approximations, with and without scattering, are presented. For control elements whose geometry does not permit a thin slab treatment, other methods are needed for determining the effective diffusion parameters. One such method, based on reaction rate ratios, is discussed.

  6. Whither α-FP in the diagnosis of hepatocellular carcinoma?

    Directory of Open Access Journals (Sweden)

    Kew MC

    2015-08-01

    Full Text Available Michael C Kew1,2 1Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, 2University of the Witwatersrand, Johannesburg, South Africaα-FP is an α1-globulin present in high concentration in the fetal serum of mammals. It is the dominant plasma protein in the developing embryo, and is synthesized by the embryonal liver, by the endodermal cells of the visceral yolk sac, and, in very small amounts, by the embryonal intestine.1 Approximately 80% of fetal hepatocytes synthesize and secrete α-FP. The protein has been closely conserved throughout phylogenesis, suggesting that it has functions essential to the fetus, although precisely what these functions are remains to be learned. There does, however, appear to be an inverse relationship between serum α-FP and albumin levels, suggesting that α-FP might function as fetal albumin.2 Other possible biological properties of the α1-globulin include binding to estrogens and bilirubin, immunosuppressive activity, and a growth-promoting potential.3 The serum level of the protein remains constant until week 32, when it begins to sharply decrease. After birth, production of α-FP normally remains completely repressed, and serum concentrations are correspondingly very low.

  7. Improved dopamine transporter binding activity after bone marrow mesenchymal stem cell transplantation in a rat model of Parkinson's disease: small animal positron emission tomography study with F-18 FP-CIT

    Energy Technology Data Exchange (ETDEWEB)

    Park, Bok-Nam; Lee, Kwanjae; An, Young-Sil [School of Medicine, Ajou University, Department of Nuclear Medicine and Molecular Imaging, Woncheon-dong, Yeongtong-gu, Gyeonggi-do, Suwon (Korea, Republic of); Kim, Jang-Hee; Park, So Hyun [Ajou University School of Medicine, Department of Pathology, Suwon (Korea, Republic of)

    2015-05-01

    We evaluated the effects of bone marrow-derived mesenchymal stem cells (BMSCs) in a model of Parkinson's disease (PD) using serial F-18 fluoropropylcarbomethoxyiodophenylnortropane (FP-CIT) PET. Hemiparkinsonian rats were treated with intravenously injected BMSCs, and animals without stem cell therapy were used as the controls. Serial FP-CIT PET was performed after therapy. The ratio of FP-CIT uptake in the lesion side to uptake in the normal side was measured. The changes in FP-CIT uptake were also analyzed using SPM. Behavioural and histological changes were observed using the rotational test and tyrosine hydroxylase (TH)-reactive cells. FP-CIT uptake ratio was significantly different in the BMSCs treated group (n = 28) at each time point. In contrast, there was no difference in the ratio in control rats (n = 25) at any time point. SPM analysis also revealed that dopamine transporter binding activity was enhanced in the right basal ganglia area in only the BMSC therapy group. In addition, rats that received BMSC therapy also exhibited significantly improved rotational behaviour and preservation of TH-positive neurons compared to controls. The therapeutic effect of intravenously injected BMSCs in a rat model of PD was confirmed by dopamine transporter PET imaging, rotational functional studies, and histopathological evaluation. (orig.)

  8. Parallel FP-Growth Algorithm Based on Constraint Rule%基于规则约束的并行 FP-Growth 算法研究

    Institute of Scientific and Technical Information of China (English)

    杨向荣; 王希武

    2015-01-01

    频繁模式增长(FP-Growth)算法是一种以发现频繁项集为基础的关联规则挖掘算法,从实际应用中发现,该算法需要挖掘出全部频繁项集,导致挖掘效率不高,并且无法适应大数据挖掘。因此,在现有研究的基础上,为适应大数据挖掘,进一步提高该算法的效率,论文针对该算法存在的不足,提出一种基于规则约束的并行 FP-Grow th 算法,即在并行计算模式(SIMD-SM )下对挖掘对象进行规则约束。%Frequent-Pattern Growth Algorithm(FP-Growth) is an association rules mining algorithm based on finding frequent itemsets .According to findings from actual applications ,this algorothm need to find out all frequent itemsets .On this account the mining efficiency becomes low and it can not accommodate big date mining .So ,on the basis of existing re-search ,a parallel FP-Growth algorithm is presented to accommodate big date mining and improve the efficiency of original al-gorithm .Parallel computing model(SIMD-SM ) and constraint rules are adopted in the new algorithm .The new algorithm can find out all frequent itemsets and can deal with mass data very well .

  9. FP-Growth算法在药物相互作用系统中的应用%Application of FP-Growth algorithm in interacting system of medicine

    Institute of Scientific and Technical Information of China (English)

    王殿君; 邵宗凯

    2015-01-01

    针对联合用药多不良反应事件频发的问题,提出使用关联规则挖掘中的FP-Growth算法进行分析运算. 通过FP-Growth算法挖掘药物相互作用数据,得出了药物相互作用的规则,并将此算法成功运用到系统中. 通过对数据库中的药物数据进行分析,对药物是否可以联合用药做出判断,进而对配药工作提供决策支持. 设计并实现了静脉注射药物相互作用分析系统. 结果表明,系统可以提高药物相互作用数据查询的速度95%左右,有利于促进合理用药和用药安全.%Aimed at the adverse drug reactions resulted from the combination of drugs, the FP - Growth in association rules mining was proposed. The drug-interaction rules were obtained by using FP-Growth algo-rithm to mine the data of drug interaction, and the algorithm was applied to the system successfully. By ana-lyzing the drug data in the database, the feasibility of the drug combination could be concluded, which could provide decision support for the work of configuring drugs. Finally, the system of intravenous drug-interaction analysis system was designed. The application results show that the query speed of drug-interaction data in-creases by 95%in the system, which is conducive to rational drug use and medication safety.

  10. Characteristics of self-worth protection in achievement behaviour.

    Science.gov (United States)

    Thompson, T

    1993-11-01

    Two experiments are reported comprising an investigation of individual difference variables associated with self-worth protection. This is a phenomenon whereby students in achievement situations adopt one of a number of strategies, including withdrawing effort, in order to avoid damage to self-esteem which results from attributing failure to inability. Experiment 1 confirmed the adequacy of an operational definition which identified self-worth students on the basis of two criteria. These were deteriorated performance following failure, together with subsequent enhanced performance following a face-saving excuse allowing students to explain failure without implicating low ability. The results of Experiment 2 established that the behaviour of self-worth protective students in achievement situations may be understood in terms of their low academic self-esteem coupled with uncertainty about their level of global self-esteem. Investigation of the manner in which self-worth students explain success and failure outcomes failed to demonstrate a tendency to internalise failure but revealed a propensity on the part of these students to reject due credit for their successes. The implications of these findings in terms of the prevention and modification of self-worth protective reactions in achievement situations are discussed.

  11. 3-5{mu}m F-P Tunable Filter Array based on MEMS technology

    Energy Technology Data Exchange (ETDEWEB)

    Xu Wei; Chen Sihai; Bao Shiwei; Zhou Yifan; Zhao Sangzhi; Luo Huan [College of Optoelectronic Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Meng Qinghua, E-mail: xw198877@gmail.com [Guangxi Normal University, Guilin541002 (China)

    2011-02-01

    In this paper the design, fabrication and test of a MEMS F-P filter operating in 3-5{mu}m range is presented. The initial design of micro-bridge structure was achieved through COMSOL simulation software. In the simulation, the micro-bridge could achieve a displacement of 0.6{mu}m under very low applied voltage of 30V, while still preserving good mirror parallelism. By using surface micromachining techniques, a 200 x 200 array of F-P tunable micro-bridge was fabricated. SEM photographs of the fabricated device and method of optical performance test are also introduced. This MEMS F-P tunable filter can be a potential application in spectroscopic sensing and optical communication system.

  12. The interplay of universities and industry through the FP5 network

    Energy Technology Data Exchange (ETDEWEB)

    Almendral, Juan A [Departamento de Fisica, Universidad Rey Juan Carlos, Tulipan s/n, 28933 Mostoles, Madrid (Spain); Oliveira, J G [Departamento de Fisica, Universidade de Aveiro, Campus Universitario de Santiago, 3810-193 Aveiro (Portugal); Lopez, L [Departamento de IngenierIa Telematica y TecnologIa Electronica, Universidad Rey Juan Carlos, Tulipan s/n, 28933 Mostoles, Madrid (Spain); Sanjuan, Miguel A F [Departamento de Fisica, Universidad Rey Juan Carlos, Tulipan s/n, 28933 Mostoles, Madrid (Spain); Mendes, J F F [Departamento de Fisica, Universidade de Aveiro, Campus Universitario de Santiago, 3810-193 Aveiro (Portugal)

    2007-06-15

    To improve the quality of life in a modern society it is essential to reduce the distance between basic research and applications, whose crucial roles in shaping today's society prompt us to seek their understanding. Existing studies on this subject, however, have neglected the network character of the interaction between universities and industry. Here we use state-of-the-art network theory methods to analyse this interplay in the so-called Framework Programme (FP)-an initiative which sets out the priorities for the European Union's research and technological development. In particular we study in the 5th FP (FP5) the role played by companies and scientific institutions and how they contribute to enhance the relationship between research and industry. Our approach provides quantitative evidence that while firms are size hierarchically organized, universities and research organizations keep the network from falling into pieces, paving the way for an effective knowledge transfer.

  13. Investigation on a fiber optic accelerometer based on FBG-FP interferometer

    Science.gov (United States)

    Lin, Chongyu; Luo, Hong; Xiong, Shuidong; Li, Haitao

    2014-12-01

    A fiber optic accelerometer based on fiber Bragg grating Fabry-Perot (FBG-FP) interferometer is presented. The sensor is a FBG-FP cavity which is formed with two weak fiber Bragg gratings (FBGs) in a single-mode fiber. The reflectivity of the two FBGs is 9.42% and 7.74% respectively, and the fiber between them is 10 meters long. An optical demodulation system was set up to analyze the reflected light of FBG-FP cavity. Acceleration signals of different frequencies and intensities were demodulated correctly and stably by the system. Based on analyzing the optical spectrum of weak FBG based FBG-FP cavity, we got the equivalent length of FBG-FP cavity. We used a path-matching Michelson interferometer (MI) to demodulate the acceleration signal. The visibility of the interference fringe we got was 41%~42% while the theory limit was 50%. This indicated that the difference of interferometer's two arms and the equivalent length of FBG-FP cavity were matched well. Phase generated carrier (PGC) technology was used to eliminate phase fading caused by random phase shift and Faraday rotation mirrors (FRMs) were used to eliminate polarization-induced phase fading. The accelerometer used a compliant cylinder design and its' sensitivity and frequency response were analyzed and simulated based on elastic mechanics. Experiment result showed that the accelerometer had a flat frequency response over the frequency range of 31-630Hz. The sensitivity was about 31dB (0dB=1rad/g) with fluctuation less than 1.5dB.

  14. ALGORITMA PARALEL FP-GROWTH UNTUK PENGGALIAN KAIDAH ASOSIASI PADA JARINGAN KOMPUTER

    Directory of Open Access Journals (Sweden)

    F.X. Arunanto

    2011-07-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Algoritma paralel untuk penggalian kaidah asosiasi pada dataset yang besar sangat dimungkinkan dengan tujuan utama untuk mengurangi waktu eksekusi. Semakin besarnya dataset, rata-rata jumlah item dalam sebuah transaksi dan rata-rata jumlah panjang large itemset yang digunakan akan menambah waktu eksekusi dalam penggalian kaidah asosisasi. Oleh karena itu, berbagai algoritma paralel banyak dikembangkan dengan seiringnya waktu, salah satunya adalah algoritma paralel FP-Growth secara trivial paralellization. Pada penelitian ini, algoritma paralel yang dibentuk akan diimplementasikan terhadap salah satu algoritma penggalian kaidah asosiasi yaitu algoritma FP-Growth. FP-Growth dipilihkarena memiliki banyak keuntungan dengan struktur data FP-Tree sebagai bentuk kompresi dataset dan tidak ada waktu yang terbuang untuk perulangan proses pengamatan dataset dibandingkan algoritma sebelumnnya seperti Apriori. Uji coba dilakukan di lingkungan komputer paralel berbasis jaringan komputer dengan menggunakan Pustaka Massage Passing Interface dan hasilnya membuktikan bahwa algoritma paralel FP-Growth menunjukkan performa yang lebih baik daripada algoritma FP-Growth pada komputer tunggal.

  15. The preclinical pharmacological study of dopamine transporter imaging agent 18F-FP-β-CIT

    Institute of Scientific and Technical Information of China (English)

    LI Xiaomin; CHEN Zhengping; WANG Songpei; TANG Jie; LIN Yansong; ZHU Zhaohui; FANG Ping

    2007-01-01

    The paper is to study pharmacologic characteristics of 18F-FP-β-CIT (18F-N-(3-fluoropropyl)-2β- carbomethoxy-3β- (4-iodophenyl)nortropane) as an imaging agent for dopamine transporter. The radiochemical purity of 18F-FP-β-CIT in aqueous solution was over 95% after standing at room temperature for 4h. Biodistribution displayed rapid uptake in rat brain (1.375 %ID/organ at 5min and 0.100 %ID/organ at 180 min) and the striatal uptake was 1.444,0.731, 0.397, 0.230 and 0.146 %ID/g at 5, 30, 60, 120 and 180 min, respectively. The values of striatum/cerebellum,striatum/frontal cortex and striatum / hippocampus in rat's brain at 30 min were 3.38, 2.17 and 2.40 respectively. The uptake in striatum can be blocked by β-CFT, suggesting that 18F-FP-β-CIT binds to DAT peculiarly. The compound was rapidly cleared from monkey's blood. The striatal uptake was bilaterally decreased in the left-sided lesioned PD rats, compared with normal control. Brain PET imaging studies in normal monkey showed that 18F-FP-β-CIT was concentrated in striatum. The test of undue toxicity showed that the dose received by mice was 1250 times as by human, which indicates that 18F-FP-β-CIT is very safe. So 18F-FP-β-CIT is a promising PET imaging agent for DAT with safety and validity.

  16. Research and Application on Web Information Retrieval Based on Improved FP-Growth Algorithm

    Institute of Scientific and Technical Information of China (English)

    JIAO Minghai; YAN Ping; JIANG Huiyan

    2006-01-01

    A kind of single linked lists named aggregative chain is introduced to the algorithm, thus improving the architecture of FP tree. The new FP tree is a one-way tree and only the pointers that point its parent at each node are kept. Route information of different nodes in a same item are compressed into aggregative chains so that the frequent patterns will be produced in aggregative chains without generating node links and conditional pattern bases. An example of Web key words retrieval is given to analyze and verify the frequent pattern algorithm in this paper.

  17. Experimental study on narrow spectral width FP lasers with a wavelength detuned band-pass filter

    Science.gov (United States)

    Fu, Junwei; Xi, Yanping; Li, Xun; Hong, Wei; Huang, Weiping

    2017-08-01

    In this paper, a 1310 nm InAlGaAs/InP multiple quantum well ridge waveguide FP laser with a built-in wavelength detuned band-pass filter has been fabricated and investigated in experiments. When compared to the reference FP laser fabricated in the same wafer, it is observed that the root-mean-square spectral width can be approximately reduced to half; and moreover, significant improvements on the transmission performances in terms of the power penalty at given transmission distance and the longest transmission distance at given bit error rate, have been achieved for the proposed laser at the same fabrication cost.

  18. Pragmatic sociology and competing orders of worth in organizations

    DEFF Research Database (Denmark)

    Jagd, Søren

    2011-01-01

    sociologists Luc Boltanski and Laurent Thévenot have contributed to this line of research with a sophisticated theoretical framework of orders of worth, which has been applied in an increasing number of empirical studies. This article explores how the order of worth framework has been applied to empirical...... primarily has been related to three main themes in organizational research: non-profit and co-operative organizations, inter-organizational co-operation, and organizational change. Third, I discuss how the pragmatic, process-oriented aspect of the research program, focusing on the intertwining of values...

  19. Trust and Competing Orders of Worth in Organizations

    DEFF Research Database (Denmark)

    Jagd, Søren

    Trust is a multi-dimensional concept. This paper suggests that a fruitful framework for bringing order to this multi-dimensionality of the trust concept is the order of worth framework developed by Luc Boltanski and Laurent Thévenot (Boltanski and Thévenot, 2006). The paper explores how trust is ...... is conceptualized differently in the seven orders of worth highlighted by Boltanski and Thévenot. Last I discuss how this perspective of competing forms of trust may contribute to trust research in organizations....

  20. The worth of radiotherapy in malignant melanomas.

    Science.gov (United States)

    Proppe, A H

    1978-08-01

    A new approach for the evaluation of the effectiveness of various forms of treatment of malignant melanomas is presented. Factors influencing the survival time from initiation of therapy until death were statistically analyzed in 548 patients who died from malignant melanoma. In slowly developing malignancies X-ray therapy was found to be superior to therapeutic methods.

  1. Simultaneous MMW generation and up-conversion for WDM-ROF systems based on FP laser

    Science.gov (United States)

    Zhang, Chan; Ning, TiGang; Li, Jing; Li, Chao; He, Xueqing; Pei, Li

    2016-10-01

    A new wavelength division multiplexing radio-over-fiber (WDM-ROF) scheme based on Fabry-Perot (FP) laser is proposed and demonstrated for simultaneous millimeter-wave (MMW) generation and up-conversion. The tunable optical comb generated by FP laser is served as a cost-effective WDM optical source in central station (CS) and it makes all-optical up-conversion process for all channels simple compared with using a DFB array. All modes from the FP laser are modulated simultaneously by a LiNbO3 Mach-Zehnder modulator (LN-MZM) then. We have systematically compared the performances of MMW generation and up-conversion using LN-MZM based on different modulation schemes. A reflective semiconductor optical amplifiers (RSOA) is used both for the downstream modulation of each channel and for the reduction of mode partition noise (MPN) induced from FP laser. In the scheme, the multiple optical carrier suppression (OCS) modulation shows the highest receiver sensitivity and smallest power penalty over long-distance delivery. In the numerical simulation, 7 WDM channels each carrying 2.5 Gb/s baseband signal have been up-converted to 60 GHz simultaneously with good performance over 25 km single mode fiber (SMF) transmission.

  2. Why does the agonist [{sup 18}F]FP-TZTP bind preferentially to the M{sub 2} muscarinic receptor?

    Energy Technology Data Exchange (ETDEWEB)

    Ravasi, L. [National Institutes of Health, PET Radiochemistry Group, National Institute for Biomedical Imaging and Bioengineering, Bethesda, MD (United States); Universita degli Studi di Milano, Institute of Radiological Sciences, Milan (Italy); Kiesewetter, D.O.; Shimoji, K. [National Institutes of Health, PET Radiochemistry Group, National Institute for Biomedical Imaging and Bioengineering, Bethesda, MD (United States); Lucignani, G. [Universita degli Studi di Milano, Institute of Radiological Sciences, Milan (Italy); European Institute of Oncology, Unit of Molecular Imaging, Division of Radiation Therapy, Milan (Italy); Eckelman, W.C. [National Institutes of Health, PET Department, Clinical Center, Bethesda, MD (United States); Molecular Tracer LLC, Bethesda, MD (United States)

    2006-03-15

    Preferential binding of FP-TZTP at the M{sub 2} receptor in vivo led to investigation of [{sup 18}F]FP-TZTP as a potential PET tracer for Alzheimer's disease, in which a substantial reduction of M{sub 2} receptors has been observed in autopsy studies. We hereby investigated in vitro the FP-TZTP behavior to further elucidate the properties of FP-TZTP that lead to its M{sub 2} selectivity. Chinese hamster ovarian cells expressing the five subtypes of human muscarinic receptor as well as the wild type were harvested in culture to assess equilibrium binding. Specific binding was calculated by subtraction of non-specific binding from total binding. Internal specific binding was calculated by subtraction of external specific binding from the total specific binding. Saturation assays were also performed to calculate B{sub max}, K{sub i}, and IC{sub 50}. In addition, equilibrium binding and dissociation kinetic studies were performed on rat brain tissue. Selected regions of interest were drawn on the digital autoradiograms and [{sup 18}F]FP-TZTP off-rates were determined by measurement of the rate of release into a buffer solution of [{sup 18}F]FP-TZTP from slide-bound cells that had been preincubated with [{sup 18}F]FP-TZTP. At equilibrium in vitro, M{sub 2} subtype selectivity of [{sup 18}F]FP-TZTP was not evident. We demonstrated that ATP-dependent mechanisms are not responsible for FP-TZTP M{sub 2} selectivity. In vitro off-rate studies from rat brain tissue showed that the off-rate of FP-TZTP varied with the percentage of M{sub 2} subtype in the tissue region. The slower dissociation kinetics of FP-TZTP from M{sub 2} receptors compared with the four other muscarinic receptor subtypes may be a factor in its M{sub 2} selectivity. (orig.)

  3. 22 CFR 134.12 - Net worth exhibit.

    Science.gov (United States)

    2010-04-01

    ... adjudicative officer in a sealed envelope labeled “Confidential Financial Information”, accompanied by a motion... Information Required From Applicants § 134.12 Net worth exhibit. (a) Each applicant except a qualifed tax... whether the applicant qualifies under the standards in his part. The adjudicative officer may require an...

  4. 15 CFR 18.12 - Net worth exhibit.

    Science.gov (United States)

    2010-01-01

    ... sealed envelope labeled “Confidential Financial Information,” accompanied by a motion to withhold the... Information Required from Applicants § 18.12 Net worth exhibit. (a) Each applicant except a qualified tax... qualifies under the standards in this part. The adjudicative officer may require an applicant to file...

  5. 42 CFR 422.382 - Minimum net worth amount.

    Science.gov (United States)

    2010-10-01

    ... or 40 percent of the minimum net worth amount in cash or cash equivalents. (2) Intangible assets. An organization may include intangible assets, the value of which is based on Generally Accepted Accounting... assets. Subject to the other provisions of this section, a PSO may apply 100 percent of the GAAP...

  6. Lives Worth Living: Religious Education and Social Movements

    Science.gov (United States)

    Ayres, Jennifer R.

    2013-01-01

    When people of faith participate in movements for social change, how are their religious and moral identities formed, challenged, and transformed? Although they have explicit and tangible goals as they participate in advocacy, protest, and boycotts, religious social activists also, James Jasper argues, craft "lives worth living" (1997).…

  7. Control rod worth calculations using deterministic and stochastic methods

    Energy Technology Data Exchange (ETDEWEB)

    Varvayanni, M. [NCSR ' DEMOKRITOS' , PO Box 60228, 15310 Aghia Paraskevi (Greece); Savva, P., E-mail: melina@ipta.demokritos.g [NCSR ' DEMOKRITOS' , PO Box 60228, 15310 Aghia Paraskevi (Greece); Catsaros, N. [NCSR ' DEMOKRITOS' , PO Box 60228, 15310 Aghia Paraskevi (Greece)

    2009-11-15

    Knowledge of the efficiency of a control rod to absorb excess reactivity in a nuclear reactor, i.e. knowledge of its reactivity worth, is very important from many points of view. These include the analysis and the assessment of the shutdown margin of new core configurations (upgrade, conversion, refuelling, etc.) as well as several operational needs, such as calibration of the control rods, e.g. in case that reactivity insertion experiments are planned. The control rod worth can be assessed either experimentally or theoretically, mainly through the utilization of neutronic codes. In the present work two different theoretical approaches, i.e. a deterministic and a stochastic one are used for the estimation of the integral and the differential worth of two control rods utilized in the Greek Research Reactor (GRR-1). For the deterministic approach the neutronics code system SCALE (modules NITAWL/XSDRNPM) and CITATION is used, while the stochastic one is made using the Monte Carlo code TRIPOLI. Both approaches follow the procedure of reactivity insertion steps and their results are tested against measurements conducted in the reactor. The goal of this work is to examine the capability of a deterministic code system to reliably simulate the worth of a control rod, based also on comparisons with the detailed Monte Carlo simulation, while various options are tested with respect to the deterministic results' reliability.

  8. 76 FR 60364 - Net Worth and Equity Ratio

    Science.gov (United States)

    2011-09-29

    ... acquired credit union's retained earnings when determining the amount of regulatory capital add-on to be... retained earnings before the latter amount is included in the net worth of the acquiring credit union. This proposed correction also limits the difference between the added retained earnings and bargain purchase...

  9. Oxygen transfer coefficient and the kinetic parameters of exo-polygalacturonase production by Aspergillus flavipes FP-500 in shake flasks and bioreactor.

    Science.gov (United States)

    Gómez Sánchez, C E; Martínez-Trujillo, A; Aguilar Osorio, G

    2012-12-01

    To evaluate and compare the sensitivity of Exo-PG production and kinetic parameters of Aspergillus flavipes FP-500 to oxygen transfer condition in shake flasks and bioreactor. Aspergillus flavipes FP-500 was grown on pectin as carbon source in shake flasks and bioreactor at different oxygen transfer conditions. The volumetric coefficient of oxygen transfer (kLa) was modified by changing both, the flask size/medium volume ratio and the agitation speed. Higher biomass concentration, Exo-PG activity, maximum specific growth rate and yield coefficient were obtained in bioreactor at higher kLa value. A strong correlation was found between biomass, Exo-PG activity and growth-associated product coefficient to kLa in bioreactor but does not in shake flasks. The mathematical model provided a good description of growth, pectin consumption and Exo-PG production in submerged batch cultures carried out in bioreactor. Biomass concentration, Exo-PG activity and their kinetics of Aspergillus flavipes FP-500 were strongly influenced by oxygen transfer condition and cultivation system. Significance and Impact of Study The production of enzymes by fungal fermentation is strictly aerobic and understanding the influence of oxygen transfer condition on the production kinetic is of vital importance in order to design, optimize and translate bioprocesses to industrial scale. © 2012 The Society for Applied Microbiology.

  10. Projects and potentialities for Scientific and Technological Cooperation between Mexico and Thailand under the European Union's Seventh Framework Program (FP7: 2007-2013

    Directory of Open Access Journals (Sweden)

    Jürgen Haberleithner

    2012-09-01

    Full Text Available The European Union and Mexico have been cooperating in the field of R&D since the partnership treaty between the Eu and Mexico took effect in 2000. With the Lisbon Strategy put into operation that same year, Europe acknowledged the central role which will be played by knowledge in the economy and society of the future. Accordingly, innovation was emphasized in order to advance mutual efforts to establish innovative research and development projects with Third Countries such as Mexico and Thailand through diverse multilateral framework programs such as the Seventh Framework Program (Fp7. A brief evaluation of the existing projects in Fp7 reveal disposition for intraregional cooperation in spite of the disparities regarding the quantity and extension of projects. Moreover, studied participants share a similar lack of know-how for coordinating projects which is at times crucial for benefiting completely from the program. Potential exists for establishing the necessary links and coordinating points amongst Mexico and Thailand under the given cooperation regional and bilateral mechanisms and the extensive research areas that the program covers. It is these specific potentialities enabled by the Fp7 in both regions that intend to be further researched for their development into multiple and successful projects.

  11. Electric service reliability cost/worth assessment in a developing country

    Science.gov (United States)

    Pandey, Mohan Kumar

    Considerable work has been done in developed countries to optimize the reliability of electric power systems on the basis of reliability cost versus reliability worth. This has yet to be considered in most developing countries, where development plans are still based on traditional deterministic measures. The difficulty with these criteria is that they cannot be used to evaluate the economic impacts of changing reliability levels on the utility and the customers, and therefore cannot lead to an optimum expansion plan for the system. The critical issue today faced by most developing countries is that the demand for electric power is high and growth in supply is constrained by technical, environmental, and most importantly by financial impediments. Many power projects are being canceled or postponed due to a lack of resources. The investment burden associated with the electric power sector has already led some developing countries into serious debt problems. This thesis focuses on power sector issues facing by developing countries and illustrates how a basic reliability cost/worth approach can be used in a developing country to determine appropriate planning criteria and justify future power projects by application to the Nepal Integrated Electric Power System (NPS). A reliability cost/worth based system evaluation framework is proposed in this thesis. Customer surveys conducted throughout Nepal using in-person interviews with approximately 2000 sample customers are presented. The survey results indicate that the interruption cost is dependent on both customer and interruption characteristics, and it varies from one location or region to another. Assessments at both the generation and composite system levels have been performed using the customer cost data and the developed NPS reliability database. The results clearly indicate the implications of service reliability to the electricity consumers of Nepal, and show that the reliability cost/worth evaluation is both

  12. Diagnostic accuracy of Parkinson disease by support vector machine (SVM) analysis of 123I-FP-CIT brain SPECT data: implications of putaminal findings and age.

    Science.gov (United States)

    Palumbo, Barbara; Fravolini, Mario Luca; Buresta, Tommaso; Pompili, Filippo; Forini, Nevio; Nigro, Pasquale; Calabresi, Paolo; Tambasco, Nicola

    2014-12-01

    Brain single-photon-emission-computerized tomography (SPECT) with I-ioflupane (I-FP-CIT) is useful to diagnose Parkinson disease (PD). To investigate the diagnostic performance of I-FP-CIT brain SPECT with semiquantitative analysis by Basal Ganglia V2 software (BasGan), we evaluated semiquantitative data of patients with suspect of PD by a support vector machine classifier (SVM), a powerful supervised classification algorithm.I-FP-CIT SPECT with BasGan analysis was performed in 90 patients with suspect of PD showing mild symptoms (bradykinesia-rigidity and mild tremor). PD was confirmed in 56 patients, 34 resulted non-PD (essential tremor and drug-induced Parkinsonism). A clinical follow-up of at least 6 months confirmed diagnosis. To investigate BasGan diagnostic performance we trained SVM classification models featuring different descriptors using both a "leave-one-out" and a "five-fold" method. In the first study we used as class descriptors the semiquantitative radiopharmaceutical uptake values in the left (L) and right (R) putamen (P) and in the L and R caudate nucleus (C) for a total of 4 descriptors (CL, CR, PL, PR). In the second study each patient was described only by CL and CR, while in the third by PL and PR descriptors. Age was added as a further descriptor to evaluate its influence in the classification performance.I-FP-CIT SPECT with BasGan analysis reached a classification performance higher than 73.9% in all the models. Considering the "Leave-one-out" method, PL and PR were better predictors (accuracy of 91% for all patients) than CL and CR descriptors; using PL, PR, CL, and CR diagnostic accuracy was similar to that of PL and PR descriptors in the different groups. Adding age as a further descriptor accuracy improved in all the models. The best results were obtained by using all the 5 descriptors both in PD and non-PD subjects (CR and CL + PR and PL + age = 96.4% and 94.1%, respectively). Similar results were observed for the "five

  13. Characterization of FP22, a large streptomycete bacteriophage with DNA insensitive to cleavage by many restriction enzymes.

    Science.gov (United States)

    Hahn, D R; McHenney, M A; Baltz, R H

    1990-12-01

    Bacteriophage FP22 has a very broad host range within streptomycetes and appeared to form lysogens of Streptomyces ambofaciens ATCC 15154. FP22 shared strong cross-immunity and antibody cross-reactivity with bacteriophage P23, but not with seven other streptomycete bacteriophages. FP22 particles had a head diameter of 71 nm and a tail length of 307 nm. The FP22 genome was 131 kb, which is the largest bacteriophage genome reported for streptomycetes. The G + C content of the genome was 46 mol% and restriction mapping indicated that FP22 DNA had discrete ends. NaCl- and pyrophosphate-resistant deletion mutants were readily isolated and the extent of the deletions defined at least 23 kb of dispensable DNA in two regions of the genome. The DNA was not cleaved by most restriction endonucleases (or isoschizomers) which have been identified in the streptomycetes, including the tetranucleotide cutter MboI (GATC).

  14. Detailed analysis for a control rod worth of the gas turbine high temperature reactor (GTHTR300)

    Energy Technology Data Exchange (ETDEWEB)

    Nakata, Tetsuo; Katanishi, Shoji; Takada, Shoji; Yan, Xing; Kunitomi, Kazuhiko [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment

    2002-11-01

    GTHTR300 is composed of a simplified and economical power plant based on an inherent safe 600 MWt reactor and a nearly 50% high efficiency gas turbine power conversion cycle. GTHTR300 core consist of annular fuel region, center and outer side reflectors because of cooling it effectively in depressurized accident conditions, and all control rods are located in both side reflectors of annular core. As a thermal neutron spectrum is strongly distorted in reflector regions, an accurate calculation is especially required for the control rod worth evaluation. In this study, we applied the detailed Monte Carlo calculations of a full core model, and confirmed that our design method has enough accuracy. (author)

  15. Prophylactic mastectomy: is it worth it?

    Science.gov (United States)

    de la Peña-Salcedo, Jose Abel; Soto-Miranda, Miguel Angel; Lopez-Salguero, Jose Fernando

    2012-02-01

    Breast cancer is the second mortality-related cancer and the leading cause of general mortality in women aged 40-55. Prophylactic mastectomy has proved to be effective in several clinical scenarios but is still a somewhat controversial procedure. We performed a retrospective study by reviewing the records of all patients who underwent prophylactic mastectomy in a 25-year period. We evaluated the aesthetic and long-term oncologic outcomes, complications, and patient satisfaction. We had 52 patients, 40 of them unilateral cases (contralateral prophylactic mastectomy) and 12 bilateral (bilateral prophylactic mastectomy) for a total of 64 mastectomized breasts. We had 1 (1.56%) case of unexpected breast cancer in the mastectomy specimens. Forty-two (65.62%) cases had a subcutaneous prophylactic mastectomy and 22 (34.37%) cases had a simple total prophylactic mastectomy. Fifty-eight (90.62%) cases underwent reconstruction with alloplastics and 6 (9.37) cases with autologous tissue of which 5 (7.81%) cases received latissimus dorsi flaps with alloplastic implants and 1 (1.56%) case had a TRAM flap. The complications included 4 (6.25%) breasts that developed capsular contracture, 2 (3.12%) cases of hematoma, and 1 (1.56%) infection. Concerning patient satisfaction, 39 (75%) patients reported being highly satisfied, 10 (19.23%) partially satisfied, and 3 (5.76%) unsatisfied. When we performed the aesthetic evaluation according to our scale, we got an overall aesthetic index of 8.8. Prophylactic mastectomy is becoming an increasingly frequent procedure. Plastic surgeons should consider the aesthetic outcome when planning mastectomy and reconstruction. Our ability to predict the high-risk population has improved and it is that population who can get the best benefit from this intervention. The recommendation against subcutaneous prophylactic mastectomy lacks scientific evidence. There is plenty of evidence that prophylactic mastectomy lowers the risk of breast cancer in the

  16. FP-tree association rules algorithm in recommendation system%基于FP-tree算法的推荐系统设计与实现

    Institute of Scientific and Technical Information of China (English)

    刘华; 张亚昕

    2015-01-01

    当前是信息爆炸的时代,推荐系统已成为解决当前网络信息超载的有效工具。文章针对网上书店的电子商务网站的销售特点,详细地设计了推荐系统,并利用挖掘技术中的FP-tree关联规则算法实现数据挖掘运算,很好的实现了在线推荐的系统功能。%This is the era of information explosion, recommendation system has become an effective tool for solving the current network information overload. Aiming at the characteristics of online bookstores sell e-commerce site, a detailed design of the recommendation system, and using mining techniques in FP-tree data mining association rules algorithm computation, to achieve a good online recommendation system functions.

  17. Is it Worth Comparing Different Bankruptcy Models?

    Directory of Open Access Journals (Sweden)

    Miroslava Dolejšová

    2015-01-01

    Full Text Available The aim of this paper is to compare the performance of small enterprises in the Zlín and Olomouc Regions. These enterprises were assessed using the Altman Z-Score model, the IN05 model, the Zmijewski model and the Springate model. The batch selected for this analysis included 16 enterprises from the Zlín Region and 16 enterprises from the Olomouc Region. Financial statements subjected to the analysis are from 2006 and 2010. The statistical data analysis was performed using the one-sample z-test for proportions and the paired t-test. The outcomes of the evaluation run using the Altman Z-Score model, the IN05 model and the Springate model revealed the enterprises to be financially sound, but the Zmijewski model identified them as being insolvent. The one-sample z-test for proportions confirmed that at least 80% of these enterprises show a sound financial condition. A comparison of all models has emphasized the substantial difference produced by the Zmijewski model. The paired t-test showed that the financial performance of small enterprises had remained the same during the years involved. It is recommended that small enterprises assess their financial performance using two different bankruptcy models. They may wish to combine the Zmijewski model with any bankruptcy model (the Altman Z-Score model, the IN05 model or the Springate model to ensure a proper method of analysis.

  18. Household net worth, racial disparities, and hormonal therapy adherence among women with early-stage breast cancer.

    Science.gov (United States)

    Hershman, Dawn L; Tsui, Jennifer; Wright, Jason D; Coromilas, Ellie J; Tsai, Wei Yann; Neugut, Alfred I

    2015-03-20

    Nonadherence to adjuvant hormonal therapy is common and is associated with increased prescription copayment amount and black race. Studies suggest that household wealth may partly explain racial disparities. We investigated the impact of net worth on disparities in adherence and discontinuation. We used the OptumInsight insurance claims database to identify women older than age 50 years diagnosed with early breast cancer, from January 1, 2007, to December 31, 2011, who were using hormonal therapy. Nonadherence was defined as a medication possession ratio of ≤ 80% of eligible days over a 2-year period. We evaluated the association of demographic and clinical characteristics, annual household income, household net worth ( $750,000), insurance type, and copayments ( $20) with adherence to hormonal therapy. Logistic regression analyses were conducted by sequentially adding sociodemographic and financial variables to race. We identified 10,302 patients; 2,473 (24%) were nonadherent. In the unadjusted analyses, adherence was negatively associated with black race (odds ratio [OR], 0.76; P Adherence was positively associated with medium (OR, 1.33; P adherence (OR, 0.76) was reduced by adding net worth to the model (OR, 0.84; P adherence (OR, 0.87; P = .08). The interaction between net worth and race was significant (P adherence. These results suggest that economic factors may contribute to disparities in the quality of care. © 2015 by American Society of Clinical Oncology.

  19. Characterization of control rod worths and fuel rod power peaking factors in the university of Utah TRIGA Mark I reactor

    Directory of Open Access Journals (Sweden)

    Alroumi Fawaz

    2016-01-01

    Full Text Available Control rod reactivity (worths for the three control rods and fuel rod power peaking factors in the University of Utah research reactor (100 kW TRIGA Mark I are characterized using the AGENT code system and the results described in this paper. These values are compared to the MCNP6 and existing experimental measurements. In addition, the eigenvalue, neutron spatial flux distributions and reaction rates are analyzed and discussed. The AGENT code system is widely benchmarked for various reactor types and complexities in their geometric arrangements of the assemblies and reactor core material distributions. Thus, it is used as a base methodology to evaluate neutronics variables of the research reactor at the University of Utah. With its much shorter computation time than MCNP6, AGENT provides agreement with the MCNP6 within a 0.5 % difference for the eigenvalue and a maximum difference of 10% in the power peaking factor values. Differential and integral control rod worths obtained by AGENT show well agreement with MCNP6 and the theoretical model. However, regulating the control rod worth is somewhat overestimated by both MCNP6 and AGENT models when compared to the experimental/theoretical values. In comparison to MCNP6, the total control rod worths and shutdown margin obtained with AGENT show better agreement to the experimental values.

  20. 胶态二氧化硅SYLOID244FP固化肉桂挥发油的研究%Study on solidifying volatile oil of cinnamon with colloidal silicon dioxide SYLOID244FP

    Institute of Scientific and Technical Information of China (English)

    蒋艳荣; 张振海; 胡绍英; 贾晓斌

    2013-01-01

    目的:评价胶态二氧化硅SYLOID244FP固化肉桂挥发油的特性.方法:采用SYLOID244FP固化肉桂挥发油,以桂皮醛收率为指标,优选SYLOID244FP用量;采用差示扫描量热法和扫描电镜法对固化粉末进行物相表征;考察SY-LOID244FP对肉桂挥发油中桂皮醛体外溶出和受热稳定性的影响.结果:SYLOID244FP与肉桂挥发油最佳固化比例1∶1,肉桂挥发油被固化之后,体外溶出速率加快,受热稳定性提高.结论:SYLOID244FP吸附固化中药挥发油值得进一步研究.%Objective:To evaluate the properties of solidifying volatile oil of cinnamon with colloidal silicon dioxide SYLOID244FP.Method:Volatile oil of cinnamon was solidified by SYLOID244FP.The amount of SYLOID244FP was optimized with the cinnamaldehyde yield as criteria.Curing powder was characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC).The effects of SYLOID244FP on dissolution in vitro and thermal stability of cinnamaldehyde were studied.Result:The optimum solidification ratio of SYLOID244FP to volatile oil of cinnamon was 1 ∶ 1.Dissolution rate of cinnamaldehyde increasesd and its thermal stability improved after volatile oil of cinnamon was solidified.Conclusion:Solidifying herbal volatile oil with SY-LOID244FP deserves studying further.

  1. 76 FR 1511 - Amendment of Class D Airspace; Fort Worth NAS JRB (Carswell Field), TX

    Science.gov (United States)

    2011-01-11

    ... Administration 14 CFR Part 71 Amendment of Class D Airspace; Fort Worth NAS JRB (Carswell Field), TX AGENCY... coordinates within the Fort Worth Naval Air Station (NAS) JRB (Carswell Field), TX, area and renames the... Regulations (14 CFR) part 71 by adjusting the geographic coordinates of the Fort Worth NAS JRB (Carswell...

  2. Case Study: A Picture Worth a Thousand Words? Making a Case for Video Case Studies

    Science.gov (United States)

    Pai, Aditi

    2014-01-01

    A picture, they say, is worth a thousand words. If a mere picture is worth a thousand words, how much more are "moving pictures" or videos worth? The author poses this not merely as a rhetorical question, but because she wishes to make a case for using videos in the traditional case study method. She recommends four main approaches of…

  3. Case Study: A Picture Worth a Thousand Words? Making a Case for Video Case Studies

    Science.gov (United States)

    Pai, Aditi

    2014-01-01

    A picture, they say, is worth a thousand words. If a mere picture is worth a thousand words, how much more are "moving pictures" or videos worth? The author poses this not merely as a rhetorical question, but because she wishes to make a case for using videos in the traditional case study method. She recommends four main approaches of…

  4. The Relationship Between Bullying and Self-Worth in Children with Movement Coordination Problems

    Science.gov (United States)

    Piek, J. P.; Barrett, N. C.; Allen, L. S. R.; Jones, A.; Louise, M.

    2005-01-01

    Past research has indicated that there is a negative relationship between victimization and self-worth. Furthermore, children with movement problems such as developmental coordination disorder (DCD) are considered at risk of both victimization and low self-worth. This study investigated the relationship between peer-victimization and self-worth in…

  5. Poor Performance in Mathematics: Is There a Basis for a Self-Worth Explanation for Women?

    Science.gov (United States)

    Thompson, Ted; Dinnel, Dale L.

    2007-01-01

    The self-worth theory of achievement motivation holds that in situations in which poor performance is likely to reveal low ability, certain students (known as self-worth protective students) intentionally withdraw effort in order to avoid the negative implications of poor performance in terms of damage to self-worth. In this study, evidence of…

  6. Clinical correlation of the binding potential with {sup 123}I-FP-CIT in de novo idiopathic Parkinson's disease patients

    Energy Technology Data Exchange (ETDEWEB)

    Berti, Valentina; Pupi, Alberto; Vanzi, Eleonora; Cristofaro, Maria Teresa de; Pellicano, Giannantonio; Mungai, Francesco [University of Florence, Clinical Pathophysiology, Florence (Italy); Ramat, Silvia; Marini, Paolo; Sorbi, Sandro [University of Florence, Neurological and Psychiatric Sciences, Florence (Italy)

    2008-12-15

    The aim of this study was to evaluate the accuracy of different single-photon emission computed tomography (SPECT) reconstruction techniques in measuring striatal N-{omega}-fluoropropyl-2{beta}-carbomethoxy-3{beta}-4-[{sup 123}I]iodophenyl-nortropane ({sup 123}I-FP-CIT) binding in de novo Parkinson's disease (PD) patients, in order to find a correlation with clinical scales of disease severity in the initial phases of disease. Thirty-six de novo PD patients underwent {sup 123}I-FP-CIT SPECT and MRI scan. SPECT data were reconstructed with filtered back projection (FBP), with an iterative algorithm (ordered subset expected maximization, OSEM) and with a method previously developed in our institution, called least-squares (LS) method. The ratio of specific to non-specific striatal {sup 123}I-FP-CIT binding (binding potential, BP) was used as the outcome measure with all the reconstruction methods (BP{sub FBP}, BP{sub OSEM}, BP{sub LS}). The range of values of striatal BP{sub LS} was significantly greater than BP{sub FBP} and BP{sub OSEM}. For all striatal regions, estimates of BP{sub FBP} correlated well with BP{sub OSEM} (r=0.84) and with BP{sub LS} (r=0.64); BP{sub OSEM} correlated significantly with BP{sub LS} (r=0.76). A good correlation was found between putaminal BP{sub LS} and Hoen and Yahr, Unified PD Rating Scale (UPDRS) and lateralized UPDRS motor scores (r=-0.46, r=-0.42, r=-0.39, respectively). Neither putaminal BP{sub FBP} nor putaminal BP{sub OSEM} correlated with any of these motor scores. In de novo PD patients, {sup 123}I-FP-CIT BP values derived from FBP and OSEM reconstruction techniques do not permit to differentiate PD severity. The LS method instead finds a correlation between striatal BP and disease severity scores. The results of this study support the use of {sup 123}I-FP-CIT BP values estimated with the LS method as a biomarker of PD severity. (orig.)

  7. Health care, human worth and the limits of the particular.

    Science.gov (United States)

    Cherry, C

    1997-10-01

    An ethics concerned with health care developments and systems must be historically continuous, especially as it concerns the application to managed structures of key moral-epistemic concepts such as care, love and empathy. These concepts are traditionally most at home in the personal, individual domain. Human beings have non-instrumental worth just because they are human beings and not by virtue of their capacities. Managed health care systems tend to abstract from this worth in respect of both individuals' distinctness and individual identity. The first, a common feature of quantitative approaches to health care assessment and delivery, is avoidable. The second, by contrast, is necessarily sacrificed in impersonally managed structures. Failure to distinguish the two encourages confusion and distress, and the demand for impossible medico-moral relationships.

  8. High spin structure of {sup 35}Cl and the sd-fp shell gap

    Energy Technology Data Exchange (ETDEWEB)

    Kshetri, Ritesh [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Saha Sarkar, M. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India)]. E-mail: maitrayee.sahasarkar@saha.ac.in; Ray, Indrani [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Banerjee, P. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Sarkar, S. [Department of Physics, Bengal Engineering and Science University, Shibpur, Howrah 711103 (India); Raut, Rajarshi [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Goswami, A. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Chatterjee, J.M. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Chattopadhyay, S. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Datta Pramanik, U. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Mukherjee, A. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Dey, C.C. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Bhattacharya, S. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Dasmahapatra, B. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Bhowal, Samit [Department of Physics, Surendranath Evening College, Kolkata 700009 (India); Gangopadhyay, G. [University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata 700009 (India); Datta, P. [Anandamohan College, 102/1, Raja Rammohan Sarani, Kolkata 700009 (India); Jain, H.C. [Tata Institute of Fundamental Research, Mumbai 400005 (India); Bhowmik, R.K. [Inter-University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi 110067 (India); Muralithar, S.; Singh, R.P.; Kumar, R. [Inter-University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi 110067 (India)

    2007-01-15

    The high spin states of {sup 35}Cl have been studied by in-beam {gamma}-spectroscopy following the fusion-evaporation reaction {sup 12}C({sup 28}Si,{alpha}p){sup 35}Cl at E{sub lab}=70 and 88 MeV, using the Indian National Gamma (Clover) Array (INGA). Lifetimes of six new excited states have been estimated for the first time. To understand the underlying structure of the levels and transition mechanisms, experimental results have been compared with those from the large basis cross-shell shell model calculations. Involvement of orbitals from fp shell and squeezing of the sd-fp shell gap seem to be essential for reliable reproduction of high spin states.

  9. A Human "eFP" Browser for Generating Gene Expression Anatograms.

    Science.gov (United States)

    Patel, Rohan V; Hamanishi, Erin T; Provart, Nicholas J

    2016-01-01

    Transcriptomic studies help to further our understanding of gene function. Human transcriptomic studies tend to focus on a particular subset of tissue types or a particular disease state; however, it is possible to collate into a compendium multiple studies that have been profiled using the same expression analysis platform to provide an overview of gene expression levels in many different tissues or under different conditions. In order to increase the knowledge and understanding we gain from such studies, intuitive visualization of gene expression data in such a compendium can be useful. The Human eFP ("electronic Fluorescent Pictograph") Browser presented here is a tool for intuitive visualization of large human gene expression data sets on pictographic representations of the human body as gene expression "anatograms". Pictographic representations for new data sets may be generated easily. The Human eFP Browser can also serve as a portal to other gene-specific information through link-outs to various online resources.

  10. A flexible testing facility for high-power targets (Tiara FP7 program)

    CERN Document Server

    Fusco, Y.; Samec, K.; Kadi, Y.

    2014-01-01

    Building on recent experience in the field of applied physics, TIARA Work package n° 9 focuses on target applications for accelerators in Europe. A roadmap for target development has been derived from major achievements in the EU-FP6 and EU-FP7 programs such as the MEGAPIE and EURISOL experiments. The TIARA management board concluded that a worthwhile continuation of such projects would be in the development of a flexible material irradiation facility easily transportable and which could be installed in different laboratories. The power is limited to 100 kW in a very compact arrangement so as to obtain the best neutron economy from a moderate beam power which is more likely to be found in laboratories across Europe. The challenges posed by such a compact design and accompanying calculations are presented in the current work.

  11. Simulations on the kindling mechanism of the asFP595 fluorescent protein

    Science.gov (United States)

    Grigorenko, Bella L.; Nemukhin, Alexander V.; Savitsky, Alexander P.

    2008-02-01

    We report the results of quantum mechanical - molecular mechanical (QM/MM) simulations aiming to elucidate the mechanism of kindling of the initially non-fluorescent protein asFP595, which is a mutated variant of the chromoprotein asCP from the sea anemone Anemonia sulcata. asFP595 becomes brightly fluorescent (kindles) with emission at 595 nm in response to intense light irradiation at 568 nm. In simulations, we use the flexible effective fragment QM/MM method with the complete active space self-consistent field (CASSCF) wavefunctions in the quantum part and the AMBER force field parameters in the molecular mechanical part. We analyze the computed scans over potential energy surfaces of the ground and excited electronic states and consider details of the working hypothesis that the trans-cis isomerization of the chromophore group inside the protein is responsible for kindling.

  12. Femtosecond laser fabricated in-line micro multicavity fiber FP interferometers sensor

    Science.gov (United States)

    Tian, Ming; Lu, Ping; Chen, Li; Liu, Deming; Yang, Minghong; Zhang, Jiangshan

    2014-04-01

    A compact micro multicavity Fabry-Perot (FP) optical fiber tip sensor is presented. In the end of the single-mode fiber (SMF), we drill a short air hole with femtosecond laser, which forms a multicavity together with the fiber flat face tip. The sensor has been experimentally tested for refractive index (RI) and temperature sensing by monitoring its wavelength shift. Simultaneous measurement of both changes in the ambient temperature and the RI can be realized using the sensitivity matrix. Measurement results show that the in-line FP exhibits the gas RI sensitivity of 867.76 nm/RIU and the temperature sensitivity of 7.8 pm/°C within the range of 24-104 °C, and the device is highly stable over time.

  13. Measurements of control rod worth by modified inverse kinetic method

    Energy Technology Data Exchange (ETDEWEB)

    Bobrov, A. A.; Lebedev, G. V., E-mail: lgv2004@mail.ru; Nechaev, Yu. A. [Russian Research Centre Kurchatov Institute (Russian Federation)

    2011-12-15

    Results of control rod worth measurements on the Astra critical assembly at the Russian Research Centre Kurchatov Institute are presented. The measurements were carried out by the modified inverse kinetics method, which is based on the use of experimental information about the variation of neutron detector readings only after introducing a reactivity perturbation. Calculated corrections are not required. The results of measurements do not depend on the neutron detector position.

  14. Differential diagnosis of Parkinsonism using dual phase F 18 FP CIT PET imaging

    Energy Technology Data Exchange (ETDEWEB)

    Jin, So Young; Oh, Min Young; Ok, Seung Jun; Oh, Jung Su; Lee, Sang Ju; Chung, Sun Ju; Lee, Chong Sik; Kim, Jae Seung [Univ. of Ulsan, Seoul (Korea, Republic of)

    2012-03-15

    Dopamine transporter (DAT) imaging can demonstrate presynaptic dopaminergic neuronal loss in Parkinson's disease (PD). However, differentiating atypical parkinsonism (APD) from PD is often difficult. We investigated the usefulness of dual phase F 18 FP CIT positron emission tomography (PET) imaging in the differential diagnosis of parkinsonism. Ninety eight subjects [five normal, seven drug induced parkinsonism (DIP), five essential tremor (ET), 24 PD, 20 multiple system atrophy parkinson type (MSA-P), 13 multiple system atrophy cerebellar type (MSA-C), 13 progressive supranuclear palsy (PSP), and 11 dementia with Lewy bodies(DLB)] underwent F 18 FP CIT PET. PET images were acquired at 5 min (early phase) and 3 h (late phase) after F 18 FP CIT administration (185MBq). Regional uptake pattern of cerebral and cerebellar hemispheres was assessed on early phase images, using visual, quantitative, and statistical parametric mapping (SPM) analyses. Striatal DAT binding was normal in normal, ET, DIP, and MSA C groups, but abnormal in PD, MSA P PSP, and DLB groups. No difference was found in regional uptake on early phase images among normal DAT binding groups, except in the MSA C group. Abnormal DAT binding groups showed different regional uptake pattern on early phase images compared with PD in SPM analysis (FDR<0.05). When discriminating APD from PD, visual interpretation of the early phase image showed high diagnostic sensitivity and specificity (75.4% and 100%, respectively). Regarding the ability to distinguish specific APD, sensitivities were 81% for MSA P, 77% for MSA C, 23% for PSP, and 54.5% for DLB. Dual phase F 18 FP CIT PET imaging is useful in demonstrating striatal DAT loss in neurodegenerative parkinsonism, and also in differentiating APD, particularly MSA, from PD.

  15. Contingencies of self-worth, academic failure, and goal pursuit.

    Science.gov (United States)

    Park, Lora E; Crocker, Jennifer; Kiefer, Amy K

    2007-11-01

    Two studies examine the effects of failure on explicit and implicit self-esteem, affect, and self-presentation goals as a function of people's trait self-esteem and academic contingency of self-worth. Study 1 shows that participants with low self-esteem (LSE) who receive failure feedback experience lower state self-esteem, less positive affect, and less desire to be perceived as competent the more they base self-worth on academics. In contrast, participants with high self-esteem (HSE) who strongly base self-worth on academics show a slight boost in state self-esteem and desire to be perceived as competent following failure. Study 2 shows that following failure, academically contingent LSE participants downplay the importance of appearing competent to others and associate themselves with failure on an implicit level. Taken together, these findings suggest that academically contingent HSE people show resilience following failure, whereas academically contingent LSE people experience negative outcomes and disengage from the pursuit of competence self-presentation goals.

  16. An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [{sup 18}F]FP-TZTP

    Energy Technology Data Exchange (ETDEWEB)

    Oosten, Erik M. van [Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6 (Canada); PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Wilson, Alan A.; Stephenson, Karin A. [PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Mamo, David C. [PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Geriatric Mental Health Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario, M6J 1H4 (Canada); Pollock, Bruce G.; Mulsant, Benoit H. [Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Geriatric Mental Health Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario, M6J 1H4 (Canada); Yudin, Andrei K. [Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6 (Canada); Houle, Sylvain [PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Vasdev, Neil [PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada); Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8 (Canada)], E-mail: neil.vasdev@camhpet.ca

    2009-04-15

    The radioligand 3-(4-(3-[{sup 18}F]fluoropropylthio)-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5, 6-tetrahydropyridine ([{sup 18}F]FP-TZTP) is an agonist with specificity towards subtype 2 of muscarinic acetylcholine (M2) receptors. It is currently the only radiotracer available for imaging M2 receptors in human subjects with positron emission tomography. The present study reports on an improved method for the synthesis of [{sup 18}F]FP-TZTP, automated using a GE TRACERlab{sup TM} FX{sub FN} radiosynthesis module. A key facet was the use of a new precursor, 3-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-ylthio) propyl 4-methylbenzenesulfonate. The precursor was fluorinated via nucleophilic displacement of the tosyloxy group by potassium cryptand [{sup 18}F]fluoride (K[{sup 18}F]/K{sub 222}) in CH{sub 3}CN at 80 deg. C for 5 min, and purified by HPLC. Formulated [{sup 18}F]FP-TZTP was prepared in an uncorrected radiochemical yield of 29{+-}4%, with a specific activity of 138{+-}41 GBq/{mu}mol (3732{+-}1109 mCi/{mu}mol) at the end of synthesis (35 min; n=3). This methodology offers higher yields, faster synthesis times, an optimized precursor, and simpler automation than previously reported.

  17. Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein IrisFP.

    Science.gov (United States)

    Colletier, Jacques-Philippe; Sliwa, Michel; Gallat, François-Xavier; Sugahara, Michihiro; Guillon, Virginia; Schirò, Giorgio; Coquelle, Nicolas; Woodhouse, Joyce; Roux, Laure; Gotthard, Guillaume; Royant, Antoine; Uriarte, Lucas Martinez; Ruckebusch, Cyril; Joti, Yasumasa; Byrdin, Martin; Mizohata, Eiichi; Nango, Eriko; Tanaka, Tomoyuki; Tono, Kensuke; Yabashi, Makina; Adam, Virgile; Cammarata, Marco; Schlichting, Ilme; Bourgeois, Dominique; Weik, Martin

    2016-03-03

    Reversibly photoswitchable fluorescent proteins find growing applications in cell biology, yet mechanistic details, in particular on the ultrafast photochemical time scale, remain unknown. We employed time-resolved pump-probe absorption spectroscopy on the reversibly photoswitchable fluorescent protein IrisFP in solution to study photoswitching from the nonfluorescent (off) to the fluorescent (on) state. Evidence is provided for the existence of several intermediate states on the pico- and microsecond time scales that are attributed to chromophore isomerization and proton transfer, respectively. Kinetic modeling favors a sequential mechanism with the existence of two excited state intermediates with lifetimes of 2 and 15 ps, the second of which controls the photoswitching quantum yield. In order to support that IrisFP is suited for time-resolved experiments aiming at a structural characterization of these ps intermediates, we used serial femtosecond crystallography at an X-ray free electron laser and solved the structure of IrisFP in its on state. Sample consumption was minimized by embedding crystals in mineral grease, in which they remain photoswitchable. Our spectroscopic and structural results pave the way for time-resolved serial femtosecond crystallography aiming at characterizing the structure of ultrafast intermediates in reversibly photoswitchable fluorescent proteins.

  18. 一个基于兴趣度的FP-Growth算法改进%A Improved Algorithm Based on Interest Degree for FP-Growth

    Institute of Scientific and Technical Information of China (English)

    曾安平; 黄永平; 阳万安; 李广军; 唐远翔

    2008-01-01

    人们已经提出了许多用于高效地发现大规模数据库中关联规则的算法,但它们大多会产生大量的关联规则,这些规则中包含很多用户不感兴趣的垃圾规则,且只能发现正项的关联规则.因此,引入兴趣度的概念,对FP-Growth算法进行改造,发现一些用户真正感兴趣的有用关联规则,这些规则允许包含负项规则.

  19. Implementation of the European multicentre database of healthy controls for [{sup 123}I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

    Energy Technology Data Exchange (ETDEWEB)

    Albert, Nathalie L.; Unterrainer, Marcus; Xiong, Guoming; Bartenstein, Peter; Koch, Walter [University of Munich, Department of Nuclear Medicine, Munich (Germany); Diemling, Markus [Hermes Medical Solutions, Stockholm (Sweden); Varrone, Andrea [Karolinska University Hospital, Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm (Sweden); Dickson, John C. [UCLH NHS Foundation Trust and University College, Institute of Nuclear Medicine, London (United Kingdom); Tossici-Bolt, Livia [University Hospitals Southampton NHS Trust, Department of Medical Physics, Southampton (United Kingdom); Sera, Terez [University of Szeged, Department of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Asenbaum, Susanne [Medical University of Vienna, Department of Neurology, Vienna (Austria); Booij, Jan [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Centre, Amsterdam (Netherlands); Kapucu, L. Oezlem A. [Gazi University, Department of Nuclear Medicine, Faculty of Medicine, Ankara (Turkey); Kluge, Andreas [ABX-CRO, Dresden (Germany); Ziebell, Morten [Rigshospitalet and University of Copenhagen, Neurobiology Research Unit, Copenhagen (Denmark); Darcourt, Jacques [University of Nice-Sophia Antipolis, Nuclear Medicine Department, Centre Antoine Lacassagne, Nice (France); Nobili, Flavio [University of Genoa, Clinical Neurology Unit, Department of Neuroscience (DINOGMI), Genoa (Italy); Pagani, Marco [Institute of Cognitive Sciences and Technologies, CNR, Rome (Italy); Karolinska Hospital, Department of Nuclear medicine, Stockholm (Sweden); Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Hesse, Swen [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Leipzig University Medical Centre, Molecular Neuroimaging IFB Adiposity Diseases, Leipzig (Germany); Borght, Thierry vander [Universite Catholique de Louvain, Nuclear Medicine Division, Mont-Godinne Medical Center, Yvoir (Belgium); Laere, Koen van [University Hospital and K.U. Leuven, Nuclear Medicine, Leuven (Belgium); Tatsch, Klaus [Staedtisches Klinikum Karlsruhe, Department of Nuclear Medicine, Karlsruhe (Germany); La Fougere, Christian [University of Tuebingen, Division of Nuclear Medicine, Department of Radiology, Tuebingen (Germany)

    2016-07-15

    Even though [{sup 123}I]FP-CIT SPECT provides high accuracy in detecting nigrostriatal cell loss in neurodegenerative parkinsonian syndromes (PS), some patients with an inconclusive diagnosis remain. We investigated whether the diagnostic accuracy in patients with clinically uncertain PS with previously inconclusive findings can be improved by the use of iterative reconstruction algorithms and an improved semiquantitative evaluation which additionally implemented a correction algorithm for patient age and gamma camera dependency (EARL-BRASS; Hermes Medical Solutions, Sweden). We identified 101 patients with inconclusive findings who underwent an [{sup 123}I]FP-CIT SPECT between 2003 and 2010 as part of the diagnostic process of suspected PS at the University of Munich, and re-evaluated these scans using iterative reconstruction algorithms and the new corrected EARL-BRASS. Clinical follow-up was obtained in 62 out of the 101 patients and constituted the gold standard for the re-evaluation to assess the possible improvement in diagnostic accuracy. Clinical follow-up confirmed the diagnosis of PS in 11 of the 62 patients. In patients in whom both visual and semiquantitative analysis showed concordant findings (48 patients), a high negative predictive value (93 %), positive predictive value (100 %) and accuracy (94 %) were found, and thus a correct diagnosis was obtained in 45 of the 48 patients. Among the 14 patients with discordant findings, the additional semiquantitative analysis correctly identified all five of nine patients patients without PS by nonpathological semiquantitative findings in visually pathological or inconclusive scans. In contrast, four of the remaining five patients with decreased semiquantitative values but visually normal scans did not show a PS during follow-up. The age-corrected and camera-corrected mode of evaluation using EARL-BRASS provided a notable improvement in the diagnostic accuracy of [{sup 123}I]FP-CIT SPECT in PS patients with

  20. Extrastriatal binding of [{sup 123}I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls

    Energy Technology Data Exchange (ETDEWEB)

    Koch, Walter; Unterrainer, Marcus; Xiong, Guoming; Bartenstein, Peter [University of Munich, Department of Nuclear Medicine, Munich (Germany); Diemling, Markus [Hermes Medical Solutions, Stockholm (Sweden); Varrone, Andrea [Karolinska University Hospital, Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm (Sweden); Dickson, John C. [UCLH NHS Foundation Trust and University College, Institute of Nuclear Medicine, London (United Kingdom); Tossici-Bolt, Livia [University Hospitals Southampton NHS Trust, Department of Medical Physics, Southampton (United Kingdom); Sera, Terez [University of Szeged, Department of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Asenbaum, Susanne [Medical University of Vienna, Department of Neurology, Vienna (Austria); Booij, Jan [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Centre, Amsterdam (Netherlands); Kapucu, Ozlem L. [Gazi University, Department of Nuclear Medicine, Faculty of Medicine, Ankara (Turkey); Kluge, Andreas [ABX-CRO, Dresden (Germany); Ziebell, Morten [Rigshospitalet and University of Copenhagen, Neurobiology Research Unit, Copenhagen (Denmark); Darcourt, Jacques [University of Nice-Sophia Antipolis, Nuclear Medicine Department, Centre Antoine Lacassagne, Nice (France); Nobili, Flavio [University of Genoa, Clinical Neurology Unit, Department of Neuroscience (DINOGMI), Genoa (Italy); Pagani, Marco [CNR, Institute of Cognitive Sciences and Technologies, Rome (Italy); Karolinska Hospital, Department of Nuclear Medicine, Stockholm (Sweden); Hesse, Swen [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Leipzig University Medical Centre, Molecular Neuroimaging IFB Adiposity Diseases, Leipzig (Germany); Borght, Thierry Vander [Universite Catholique de Louvain, Nuclear Medicine Division, CHU Dinant Godinne, Yvoir (Belgium); Laere, Koen van [University Hospital and K.U. Leuven, Nuclear Medicine, Leuven (Belgium); Tatsch, Klaus [Staedtisches Klinikum Karlsruhe, Department of Nuclear Medicine, Karlsruhe (Germany); La Fougere, Christian [University of Munich, Department of Nuclear Medicine, Munich (Germany); University of Tuebingen, Department of Nuclear Medicine, Tuebingen (Germany)

    2014-10-15

    Apart from binding to the dopamine transporter (DAT), [{sup 123}I]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls. SPECT data from 103 healthy controls with well-defined criteria of normality acquired at 13 different imaging centres were analysed for extrastriatal binding using volumes of interest analysis for the thalamus and the pons. Data were examined for gender and age effects as well as for potential influence of striatal DAT radiotracer binding. Thalamic binding was significantly higher than pons binding. Partial correlations showed an influence of putaminal DAT binding on measured binding in the thalamus but not on the pons. Data showed high interindividual variation in extrastriatal binding. Significant gender effects with 31 % higher binding in women than in men were observed in the thalamus, but not in the pons. An age dependency with a decline per decade (±standard error) of 8.2 ± 1.3 % for the thalamus and 6.8 ± 2.9 % for the pons was shown. The potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [{sup 123}I]FP-CIT scans in healthy controls. For both the thalamus and the pons, an age-related decline in radiotracer binding was observed. Gender effects were demonstrated for binding in the thalamus only. As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [{sup 123}I]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors. (orig.)

  1. Monitoring of experimental rat lung transplants by high-resolution flat-panel volumetric computer tomography (fpVCT).

    Science.gov (United States)

    Greschus, Susanne; Kuchenbuch, Tim; Plötz, Christian; Obert, Martin; Traupe, Horst; Padberg, Winfried; Grau, Veronika; Hirschburger, Markus

    2009-01-01

    Noninvasive assessment of experimental lung transplants with high resolution would be favorable to exclude technical failure and to follow up graft outcome in the living animal. Here we describe a flat-panel Volumetric Computed Tomography (fpVCT) technique using a prototype scanner. Lung transplantation was performed in allogeneic as well as in corresponding syngeneic rat strain combinations. At different time points post-transplantation, fpVCT was performed. Lung transplants can be visualized in the living rat with high-spatial resolution. FpVCT allows a detailed analysis of the lung and the bronchi. Infiltrates developing during rejection episodes can be diagnosed and follow-up studies can easily be performed. With fpVCT it is possible to control the technical success of the surgical procedure. Graft rejection can be visualized individually in the living animal noninvasively, which is highly advantageous for studying the pathogenesis of chronic rejection or to monitor new therapies.

  2. Why are infant and child mortality rates lower in the MCH-FP area of Matlab, Bangladesh?

    Science.gov (United States)

    Hale, Lauren; DaVanzo, Julie; Razzaque, Abdur; Rahman, Mizanur

    2006-12-01

    Infant and child mortality rates are significantly lower in the Maternal and Child Health-Family Planning (MCH-FP) area of Matlab, Bangladesh, than in a comparison area. The two areas are similar in terms of socioeconomic characteristics, but the MCH-FP area provides better maternal and child health and family planning services, resulting in different reproductive patterns, including lower fertility rates and longer intervals between pregnancies. We use data from the Matlab Demographic Surveillance System for nearly 126,000 singleton live births that occurred between 1982 and 2002 to investigate the extent to which the different reproductive patterns in the MCH-FP area explain why infant and child mortality rates are lower there. Differences in reproductive patterns account for a small portion (up to 20 percent) of the variation in these rates between the MCH-FP and comparison areas, suggesting that the majority of the difference is due to the quality of MCH services.

  3. Reactivity worth measurements with Caliban and Silene experimental reactors

    Energy Technology Data Exchange (ETDEWEB)

    Casoli, P.; Authier, N. [CEA Valduc, 21 - Is-sur-Tille (France)

    2008-07-01

    Reactivity worth measurements of material samples put in the central cavities of nuclear reactors allow to test cross section nuclear databases or to extract information about the critical masses of fissile elements. Such experiments have already been completed on the CALIBAN and SILENE experimental reactors operated by the Criticality and Neutronics Research Laboratory of Valduc (Cea, France), using the perturbation measurement technique. Feasibility studies have been performed to prepare future experiments on new materials (beryllium, copper, tantalum, {sup 237}Np) and results show that the obtained values for most materials are clearly above the measurement limits and then the perturbation technique can be used even with smaller size samples.

  4. 123I-FP-CIT brain SPECT (DaTSCAN imaging in the diagnosis of patients with movement disorders: First results

    Directory of Open Access Journals (Sweden)

    Jauković Ljiljana

    2012-01-01

    Full Text Available Background/Aim. 123I-FP-CIT brain single-photon emission computed tomography (SPECT, DaTSCAN imaging, offers a possibility to study structural and biochemical integrity of presinaptic dopaminergic neurotransmitter system. The aim of this study was to evaluate the usefulness of 123I-FP-CIT brain SPECT scintigraphy in patients with extrapyramidal diseases. Methods. Fifteen patients (8 males and 7 females, aged 26-81 years, presenting with extrapyramidal symptoms entered the study. Out of them, 7 patients were diagnosed with definite clinical form of idiopathic Parkinson’s disease (PD or clinical probable for PD clinical stage 2-4 using the Hoehn&Yahr scale (H&Y; 6 patients were with atypical parkinsonism (AP, 1 patient with essential, and 1 with psychogenic tremor. SPECT was performed 180 min after injection of 185 MBq 123IFP- CIT using a dual head Gamma camera. Sixty four one minutes’ frames were acquired using a noncircular rotation mode into a 128 × 128 image matrix. Transverse slices were reconstructed using a 0.6 order Butterworth filter. Visual interpretation was based on striatal uptake, left to right asymmetry and substructures most affected. The ratio of binding for the entire striatum, caudate and putamen to nonspecific binding in occipital cortex was calculated. SPECT findings were categorized as normal and abnormal (incipient, moderate and severe presinaptic deficit. Results. 123I-FP-CIT uptake was reduced in the striatum of 6/7 patients with PD and 5/6 patients with AP. Two patients with PD and AP showed a negative finding. The remaining 2 negative results were obtained in the patients diagnosed with essential tremor and psychogenic tremor. The mean striato-occipital ratio (SDR of the most affected side was lower in the patients with PD. Conclusion. Our first results confirm the usefulness of 123I-FPCIT brain SPECT in differential diagnosis of extrapyramidal diseases.

  5. Decreased serotonin transporters in the hypothalamus and midbrain in patients with multiple systemic atrophy: a study with [{sup 123}I]-FP-CITA

    Energy Technology Data Exchange (ETDEWEB)

    Oh, So Won; Kim, Yu Kyeong; Kim, Jon Min; Eo, Jae Seon; Lee, Won Woo; Kim, Sang Eun [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2005-07-01

    We investigated quantification of dopaminergic transporter (DAT) and serotonergic transporter (SERT) for differentiating between multiple systemic atrophy (MSA) and idiopathic Parkinsons disease (IPD). Nfluoropropyl- 2{beta}-carbomethoxy-3{beta}-4-[{sup 123}I]-iodophenylnortropane SPECT ([123I]-FP-CIT SPECT) was performed in 6 patients with MSA, 18 with early IPD, and 6 healthy controls. Standard ROIs (region of interests) of striatal regions to evaluate DAT, and hypothalamus and midbrain for SERT were drawn on standard template images and applied to each image taken 4 hours after radiotracer injection. Striatal V3? for DAT and hypothalamic and midbrain V3? for SERT were calculated using region/reference ration based on the transient equilibrium method. Group differences were tested using ANOVA with the postHoc analysis. DAT in the putamen was significantly decreased in both patients groups with MSA and early IPD, compared with healthy control (p=0.03, p=0.05, respectively). A reduction of DAT in the caudate was significant in MSA patients (p=0.05) and showed a trend in early IPD patient. This implied least involvement of caudate in early IPD. Regarding SERT, MSA patients showed significant reduction of SERT in hypothalamus compared with controls as well as early IPD patients (p=0.05, 0.01, respectively), and also showed a tendency of decrease in SERT of the midbrain (p=0.058 vs, control). In patients with IPD, there was no significant reduction of SERT in the hypothalamus or midbrain when compared with controls. In this study, the decreased SERT in the hypothalamus and midbrain could be demonstrated in MSA patients using [{sup 123}I]-FP-CIT SPECT. We suggest that the quantification of SERT as well as DAT in [{sup 123}I]-FP-CIT SPECT is helpful to differentiate Parkinsonian disorders.

  6. trans and cis Chromophore structures in the kindling fluorescent protein asFP595

    Science.gov (United States)

    Grigorenko, Bella; Savitsky, Alexander; Topol, Igor; Burt, Stanley; Nemukhin, Alexander

    2006-06-01

    The ab initio QM/MM calculations are used to optimize geometry configurations of the chromophore and surrounding residues for the kindling protein asFP595. The time-dependent DFT method is applied to estimate parameters of the S 0-S 1 vertical transition of the chromophore at the protein geometry taking into account effects from the nearest residues. The results of simulations provide a theoretical support to the hypothesis on the possibility of trans-cis izomerization of the chromophore in the mechanism of kindling. The system can absorb light in the trans anion form of the chromophore and emit at longer wavelength in the cis anion form.

  7. Time-series photometry of the O4 I(n)fp star zeta Puppis

    OpenAIRE

    Howarth, Ian D.; Stevens, Ian R.

    2014-01-01

    We report a time-series analysis of the O4 I(n)fp star zeta Pup, based on optical photometry obtained with the SMEI instrument on the Coriolis satellite, 2003--2006. A single astrophysical signal is found, with P = (1.780938 \\pm 0.000093) d and a mean semi-amplitude of (6.9 \\pm 0.3) mmag. There is no evidence for persistent coherent signals with semi-amplitudes in excess of ca. 2~mmag on any of the timescales previously reported in the literature. In particular, there is no evidence for a sig...

  8. Manifestations of Isospin in Nearest Neighbor Spacing Distributions for the f-p Model Space

    CERN Document Server

    Quinonez, Michael; Zamick, Larry

    2016-01-01

    The strong interactions are charge independent. If we limit ourselves to the strong interactions, we have the isospin $T$ as a good quantum number. Here we consider the lack of level repulsion of states of different isospin and how this effect manifests in nearest neighbor spacing (NNS) histograms, which provide a visual and statistical context in which to study distributions of energy level spacings. In particular, we study nucleons in the f-p model space for the nucleus $^{44}$Ti. We also study the effect of the Coulomb interaction on the level spacing distribution.

  9. File Specification for GEOS-5 FP-IT (Forward Processing for Instrument Teams)

    Science.gov (United States)

    Lucchesi, R.

    2013-01-01

    The GEOS-5 FP-IT Atmospheric Data Assimilation System (GEOS-5 ADAS) uses an analysis developed jointly with NOAA's National Centers for Environmental Prediction (NCEP), which allows the Global Modeling and Assimilation Office (GMAO) to take advantage of the developments at NCEP and the Joint Center for Satellite Data Assimilation (JCSDA). The GEOS-5 AGCM uses the finite-volume dynamics (Lin, 2004) integrated with various physics packages (e.g, Bacmeister et al., 2006), under the Earth System Modeling Framework (ESMF) including the Catchment Land Surface Model (CLSM) (e.g., Koster et al., 2000). The GSI analysis is a three-dimensional variational (3DVar) analysis applied in grid-point space to facilitate the implementation of anisotropic, inhomogeneous covariances (e.g., Wu et al., 2002; Derber et al., 2003). The GSI implementation for GEOS-5 FP-IT incorporates a set of recursive filters that produce approximately Gaussian smoothing kernels and isotropic correlation functions. The GEOS-5 ADAS is documented in Rienecker et al. (2008). More recent updates to the model are presented in Molod et al. (2011). The GEOS-5 system actively assimilates roughly 2 × 10(exp 6) observations for each analysis, including about 7.5 × 10(exp 5) AIRS radiance data. The input stream is roughly twice this volume, but because of the large volume, the data are thinned commensurate with the analysis grid to reduce the computational burden. Data are also rejected from the analysis through quality control procedures designed to detect, for example, the presence of cloud. To minimize the spurious periodic perturbations of the analysis, GEOS-5 FP-IT uses the Incremental Analysis Update (IAU) technique developed by Bloom et al. (1996). More details of this procedure are given in Appendix A. The analysis is performed at a horizontal resolution of 0.625-degree longitude by 0.5-degree latitude and at 72 levels, extending to 0.01 hPa. All products are generated at the native resolution of the

  10. Improvements in start system of ETE-RH/FP fans; Melhorias no sistema de partida dos ventiladores da ETE-RH/FP

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, Flavio Costa; Sinzato, Frederico Takashi Di Tanno; Assis, Marcio Souza de [ArcelorMittal Tubarao, ES (Brazil). Dept. de Producao de Gusa e Energia

    2009-11-01

    The present technical contribution presents the results achieved with the improvement of start control of Effluent Treatment Station of RH furnace and Ladle furnace (ETE-RH/FP) fans. This work started from the necessity to find a solution to decrease the constant mechanical breaks of fans on the station, where it has been used two fans per cell in the tower, which means that when one is working, the other in the same cell is turned off. The second fan turns the other way round, and when the same is turned on it causes a 'bang' strong enough to break its elements, such as braces and gears. With the use of soft start, the same, besides to start the motor of the fan in a soft way, still does that the fan stop turning the other way round before the start, preventing the 'bangs' in the equipment. Another important item considered in the solution was the harmonic generation. The soft start generate few harmonic, if compared to a frequency inverter. The introduction of this new start system of fans of station, besides the reduction of costs of the repair maintenance, brought an important electrical energy saving, being aligned with the new projects of the company. (author)

  11. Summary of important results and SCDAP/RELAP5 analysis for OECD LOFT experiment LP-FP-2

    Energy Technology Data Exchange (ETDEWEB)

    Coryell, E.W. [EG and G Idaho, Inc., Idaho Falls, ID (United States)

    1994-04-01

    This report summarizes significant technical findings from the LP-FP-2 Experiment sponsored by the Organization of Economic Cooperation and Development (OECD). It was the second, and final, fission product experiment conducted in the Loss-of-Fluid Test (LOFT) facility at the Idaho National Engineering Laboratory. The overall technical objective of the test was to contribute to the understanding of fuel rod behavior, hydrogen generation, and fission product release, transport, and deposition during a V-sequence accident scenario that resulted in severe core damage. An 11 by 11 test bundle, comprised of 100 prepressurized fuel rods, 11 control rods, and 10 instrumented guide tubes, was surrounded by an insulating shroud and contained in a specially designed central fuel module, that was inserted into the LOFT reactor. The simulated transient was a V-sequence loss-of-coolant accident scenario featuring a pipe break in the low pressure injection system line attached to the hot leg of the LOFT broken loop piping. The transient was terminated by reflood of the reactor vessel when the outer wall shroud temperature reached 1517 K. With sustained fission power and heat from oxidation and metal-water reactions, elevated temperatures resulted in zircaloy melting, fuel liquefaction, material relocation, and the release of hydrogen, aerosols, and fission products. A description and evaluation of the major phenomena, based upon the response of on line instrumentation, analysis of fission product data, postirradiation examination of the fuel bundle, and calculations using the SCDAP/RELAP5 computer code, are presented.

  12. Global properties of fp-shell interactions in many-nucleon systems

    Energy Technology Data Exchange (ETDEWEB)

    Sviratcheva, K.D. [Department of Physics and Astronomy, Louisiana State University, Baton Rouge, Louisiana 70803 (United States)]. E-mail: kristina@baton.phys.lsu.edu; Draayer, J.P. [Department of Physics and Astronomy, Louisiana State University, Baton Rouge, Louisiana 70803 (United States); Vary, J.P. [Department of Physics and Astronomy, Iowa State University, Ames, IA 50011 (United States); Lawrence Livermore National Laboratory, Livermore, California 94551, Stanford Linear Accelerator Center, Stanford University, Stanford, CA 94309 (United States)

    2007-04-15

    Spectral distribution theory, which can be used to compare microscopic interactions over a broad range of nuclei, is applied in an analysis of two modern effective interactions based on the realistic CD-Bonn potential for 0{omega} no-core shell model calculations in the fp shell, as well as in a comparison of these with the realistic shell-model GXPF1 interaction. In particular, we explore the ability of these interaction to account for the development of isovector pairing correlations and collective rotational motion in the fp shell. Our findings expose the similarities of these two-body interactions, especially as this relates to their pairing and rotational characteristics. Further, the GXPF1 interaction is used to determine the strength parameter of a quadrupole term that can be used to augment an isovector-pairing model interaction with Sp(4) dynamical symmetry, which in turn is shown to yield reasonable agreement with the low-lying energy spectra of {sup 58}Ni and {sup 58}Cu.

  13. A Human "eFP" Browser for Generating Gene Expression Anatograms.

    Directory of Open Access Journals (Sweden)

    Rohan V Patel

    Full Text Available Transcriptomic studies help to further our understanding of gene function. Human transcriptomic studies tend to focus on a particular subset of tissue types or a particular disease state; however, it is possible to collate into a compendium multiple studies that have been profiled using the same expression analysis platform to provide an overview of gene expression levels in many different tissues or under different conditions. In order to increase the knowledge and understanding we gain from such studies, intuitive visualization of gene expression data in such a compendium can be useful. The Human eFP ("electronic Fluorescent Pictograph" Browser presented here is a tool for intuitive visualization of large human gene expression data sets on pictographic representations of the human body as gene expression "anatograms". Pictographic representations for new data sets may be generated easily. The Human eFP Browser can also serve as a portal to other gene-specific information through link-outs to various online resources.

  14. A Magnetic Field Sensor Based on a Magnetic Fluid-Filled FP-FBG Structure

    Directory of Open Access Journals (Sweden)

    Ji Xia

    2016-04-01

    Full Text Available Based on the characteristic magnetic-controlled refractive index property, in this paper, a magnetic fluid is used as a sensitive medium to detect the magnetic field in the fiber optic Fabry-Perot (FP cavity. The temperature compensation in fiber Fabry-Perot magnetic sensor is demonstrated and achieved. The refractive index of the magnetic fluid varies with the applied magnetic field and external temperature, and a cross-sensitivity effect of the temperature and magnetic field occurs in the Fabry-Perot magnetic sensor and the accuracy of magnetic field measurements is affected by the thermal effect. In order to overcome this problem, we propose a modified sensor structure. With a fiber Bragg grating (FBG written in the insert fiber end of the Fabry-Perot cavity, the FBG acts as a temperature compensation unit for the magnetic field measurement and it provides an effective solution to the cross-sensitivity effect. The experimental results show that the sensitivity of magnetic field detection improves from 0.23 nm/mT to 0.53 nm/mT, and the magnetic field measurement resolution finally reaches 37.7 T. The temperature-compensated FP-FBG magnetic sensor has obvious advantages of small volume and high sensitivity, and it has a good prospect in applications in the power industry and national defense technology areas.

  15. Modeling trans-cis chromophore isomerization for the asFP595 kindling protein

    Science.gov (United States)

    Grigorenko, Bella L.; Nemukhin, Alexander V.

    2007-02-01

    We present the results of modeling properties of the chromophore, 2-acetyl-4-(p-hydroxybenzylidene)-1-methyl-5- imidazolone (AHBMI), from the newly discovered fluorescent protein asFP595 inside the protein environment by using the combined quantum mechanical - molecular mechanical (QM/MM) method. In this approach, the chromophore unit and the side chains of the nearest amino acid residues are assigned to the quantum subsystem. The starting coordinates of heavy atoms were taken from the relevant crystal structures of the protein. Hydrogen atoms were added manually, and the structure of the model protein system was optimized by using QM/MM energy minimization for the trans-form of the chromophore. The Hartree-Fock/6-31G quantum chemical approximation and the AMBER force field parameters were employed in geometry optimization. The points on potential energy surfaces of the ground and first and second excited electronic states were computed with the complete active space self-consistent field approximation in the quantum subsystem under different choices of the QM/MM partitioning. Possible pathways for the trans-cis photo isomerization presumably responsible for the kindling properties of asFP595 as well as other mechanisms of photo excitation are discussed.

  16. Hybrid wireless-over-fiber transmission system based on multiple injection-locked FP LDs.

    Science.gov (United States)

    Li, Chung-Yi; Lu, Hai-Han; Chu, Chien-An; Ying, Cheng-Ling; Lu, Ting-Chien; Peng, Peng-Chun

    2015-07-27

    A hybrid wireless-over-fiber (WoF) transmission system based on multiple injection-locked Fabry-Perot laser diodes (FP LDs) is proposed and experimentally demonstrated. Unlike the traditional hybrid WoF transmission systems that require multiple distributed feedback (DFB) LDs to support different kinds of services, the proposed system employs multiple injection-locked FP LDs to provide different kinds of applications. Such a hybrid WoF transmission system delivers downstream intensity-modulated 20-GHz microwave (MW)/60-GHz millimeter-wave (MMW)/550-MHz cable television (CATV) signals and upstream phase-remodulated 20-GHz MW signal. Excellent bit error rate (BER), carrier-to-noise ratio (CNR), composite second-order (CSO), and composite triple-beat (CTB) are observed over a 40-km single-mode fiber (SMF) and a 4-m radio frequency (RF) wireless transport. Such a hybrid WoF transmission system has practical applications for fiber-wireless convergence to provide broadband integrated services, including telecommunication, data communication, and CATV services.

  17. A Magnetic Field Sensor Based on a Magnetic Fluid-Filled FP-FBG Structure.

    Science.gov (United States)

    Xia, Ji; Wang, Fuyin; Luo, Hong; Wang, Qi; Xiong, Shuidong

    2016-04-29

    Based on the characteristic magnetic-controlled refractive index property, in this paper, a magnetic fluid is used as a sensitive medium to detect the magnetic field in the fiber optic Fabry-Perot (FP) cavity. The temperature compensation in fiber Fabry-Perot magnetic sensor is demonstrated and achieved. The refractive index of the magnetic fluid varies with the applied magnetic field and external temperature, and a cross-sensitivity effect of the temperature and magnetic field occurs in the Fabry-Perot magnetic sensor and the accuracy of magnetic field measurements is affected by the thermal effect. In order to overcome this problem, we propose a modified sensor structure. With a fiber Bragg grating (FBG) written in the insert fiber end of the Fabry-Perot cavity, the FBG acts as a temperature compensation unit for the magnetic field measurement and it provides an effective solution to the cross-sensitivity effect. The experimental results show that the sensitivity of magnetic field detection improves from 0.23 nm/mT to 0.53 nm/mT, and the magnetic field measurement resolution finally reaches 37.7 T. The temperature-compensated FP-FBG magnetic sensor has obvious advantages of small volume and high sensitivity, and it has a good prospect in applications in the power industry and national defense technology areas.

  18. Space weather in the EU’s FP7 Space Theme

    Directory of Open Access Journals (Sweden)

    Chiarini Paola

    2013-11-01

    Full Text Available Technological infrastructures in space and on ground provide services on which modern society and economies rely. Space weather related research is funded under the 7th Framework Programme for Research and Innovation (FP7 of the European Union in response to the need of protecting such critical infrastructures from the damage which could be caused by extreme space weather events. The calls for proposals published under the topic “Security of space assets from space weather events” of the FP7 Space Theme aimed to improve forecasts and predictions of disruptive space weather events as well as identify best practices to limit the impacts on space- and ground-based infrastructures and their data provision. Space weather related work was also funded under the topic “Exploitation of space science and exploration data”, which aims to add value to space missions and Earth-based observations by contributing to the effective scientific exploitation of collected data. Since 2007 a total of 20 collaborative projects have been funded, covering a variety of physical phenomena associated with space weather, from ionospheric disturbances and scintillation, to geomagnetically induced currents at Earth’s surface, to coronal mass ejections and solar energetic particles. This article provides an overview of the funded projects, touching upon some results and referring to specific websites for a more exhaustive description of the projects’ outcomes.

  19. Control rod reactivity worth determination of a typical MTR research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Rizwan, M.; Raza, S.S.; Khan, R. [Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad (Pakistan). Dept. of Nuclear Engineering

    2015-10-15

    The safe and reliable utilization of research reactor demands the possible accurate information of control rod (CR) worths. The criticality positions of the control rods changes with time due to build up fission products. It is therefore important to determine the reactivity worth of control rods. The aim of this article is to estimate the reactivity worth of controls rods in the equilibrium core of a Materials Testing Reactor (MTR). A deterministic model of the reactor core was developed and confirmed against the reference results of excess reactivity, shutdown margin and combined control rod reactivity worth using the combination of WIMS/D4 and CITATION computer codes.

  20. Production of baculovirus defective interfering particles during serial passage is delayed by removing transposon target sites in fp25k.

    Science.gov (United States)

    Giri, Lopamudra; Feiss, Michael G; Bonning, Bryony C; Murhammer, David W

    2012-02-01

    Accumulation of baculovirus defective interfering particle (DIP) and few polyhedra (FP) mutants is a major limitation to continuous large-scale baculovirus production in insect-cell culture. Although overcoming these mutations would result in a cheaper platform for producing baculovirus biopesticides, little is known regarding the mechanism of FP and DIP formation. This issue was addressed by comparing DIP production of wild-type (WT) Autographa californica multiple nucleopolyhedrovirus (AcMNPV) with that of a recombinant AcMNPV (denoted Ac-FPm) containing a modified fp25k gene with altered transposon insertion sites that prevented transposon-mediated production of the FP phenotype. In addition to a reduction in the incidence of the FP phenotype, DIP formation was delayed on passaging of Ac-FPm compared with WT AcMNPV. Specifically, the yield of DIP DNA in Ac-FPm was significantly lower than in WT AcMNPV up to passage 16, thereby demonstrating that modifying the transposon insertion sites increases the genomic stability of AcMNPV. A critical component of this investigation was the optimization of a systematic method based on the use of pulsed-field gel electrophoresis (PFGE) to characterize extracellular virus DNA. Specifically, PFGE was used to detect defective genomes, determine defective genome sizes and quantify the amount of defective genome within a heterogeneous genome population of passaged virus.

  1. Providers' perspectives on male involvement in family planning in the context of a cluster-randomized controlled trial evaluating integrating family planning into HIV care in Nyanza Province, Kenya.

    Science.gov (United States)

    Tao, Amy R; Onono, Maricianah; Baum, Sarah; Grossman, Daniel; Steinfeld, Rachel; Cohen, Craig R; Bukusi, Elizabeth A; Newmann, Sara J

    2015-01-01

    Integration of family planning (FP) services into HIV care and increasing male partner involvement in FP are being explored as strategies to reduce unmet need for contraception. Providers' views can give valuable insight into current FP care. We evaluated the perspectives of HIV care providers working at HIV clinics in Nyanza Province, Kenya, on male partner involvement in FP. This qualitative study was part of a cluster-randomized controlled trial evaluating the impact of integrating FP into HIV services on contraceptive prevalence among HIV-positive patients in Nyanza Province, Kenya. Thirty individual interviews were conducted among health-care workers at 11 HIV care facilities in Nyanza Province, Kenya. Interviews were conducted from integrated and control sites one year after implementation of FP/HIV integration. Data were transcribed and analyzed using grounded theory methods and ATLAS-ti. Providers supported male partner inclusion when choosing FP and emphasized that decisions should be made collaboratively. Providers believed that men have traditionally played a prohibitive role in FP but identified several benefits to partner involvement in FP decision-making including: reducing relationship conflicts, improving FP knowledge and contraceptive continuation, and increasing partner cohesion. Providers suggested that integrated FP/HIV services facilitate male partner involvement in FP decision-making since HIV-positive men are already established patients in HIV clinics. Some providers stated that women had a right to choose and start FP alone if their partners did not agree with using FP. Integrated FP services may be a useful strategy to help increase male participation to reduce the unmet FP need in sub-Saharan Africa. It is important to determine effective ways to engage male partners in FP, without impinging upon women's autonomy and reproductive rights.

  2. Safety and immunogenicity of the malaria candidate vaccines FP9 CS and MVA CS in adult Gambian men.

    Science.gov (United States)

    Imoukhuede, E B; Berthoud, T; Milligan, P; Bojang, K; Ismaili, J; Keating, S; Nwakanma, D; Keita, S; Njie, F; Sowe, M; Todryk, S; Laidlaw, S M; Skinner, M A; Lang, T; Gilbert, S; Greenwood, B M; Hill, A V S

    2006-10-30

    We assessed the safety and immunogenicity of prime-boost vectors encoding the Plasmodium falciparum circumsporozoite (CS) protein expressed either in the attenuated fowl-pox virus (FP9) or modified vaccinia virus Ankara (MVA). Thirty-two adult Gambians in groups of four to eight received one, two or three doses of FP9 CS and/or MVA CS. No serious adverse event was observed following vaccination. The most immunogenic regimen was two doses of FP9 followed by a single dose of MVA 4 weeks later (an average of 1000 IFN-gamma spot forming units/million PBMCs). This level of effector T-cell responses appears higher than that seen in previously reported studies of CS-based candidate malaria vaccines.

  3. LanFP10-A, first functional fluorescent protein whose chromophore contains the elusive mutation G67A.

    Science.gov (United States)

    Roldán-Salgado, Abigail; Sánchez-Barreto, Celidee; Gaytán, Paul

    2016-11-01

    Since Green Fluorescent Protein (GFP) was first successfully expressed in heterologous systems in 1994, many genes encoding other natural autofluorescent proteins (AFPs) have been cloned and subsequently modified by protein engineering to improve their physicochemical properties. Throughout this twenty-two-year period, glycine 67 (Gly67) has been regarded as the only amino acid in the entire protein family that is essential for the formation of the different reported chromophores. In this work, we demonstrate that a synthetic gene encoding LanFP10-A, a natural protein encoded in the genome of the lancelet Branchiostoma floridae containing the G67A mutation, produces a heterologous, functional yellow fluorescent protein when expressed in E. coli. In contrast to LanFP10-A, LanFP6-A, a second GFP-like protein found in the lancelet genome that also contains the natural G67A mutation, was non-fluorescent.

  4. Correlation between neuromelanin-sensitive MR imaging and {sup 123}I-FP-CIT SPECT in patients with parkinsonism

    Energy Technology Data Exchange (ETDEWEB)

    Kuya, Keita; Shinohara, Yuki; Miyoshi, Fuminori; Fujii, Shinya; Tanabe, Yoshio; Ogawa, Toshihide [Tottori University, Division of Radiology, Department of Pathophysiological Therapeutic Science, Faculty of Medicine, Yonago (Japan)

    2016-04-15

    Neuromelanin-sensitive MR imaging (MRI) can visualize neuromelanin-containing neurons in the substantia nigra pars compacta (SNc), and its utility has been reported in the evaluation of parkinsonism. Conversely, dopamine transporter imaging by {sup 123}I-N-v-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl)nortropane (FP-CIT) SPECT (DaTSCAN) is now an established method for evaluating parkinsonism, detecting presynaptic dopamine neuronal dysfunction. Both methods can assist differentiating neurodegenerative and other forms of parkinsonism. However, to our knowledge, there have been no studies concerning a correlation between the two methods. The aim of this study was to assess the utility of neuromelanin-sensitive MRI for diagnosing parkinsonism by examining a correlation with DaTSCAN. Twenty-three patients with parkinsonism who underwent both neuromelanin-sensitive MRI and DaTSCAN were included. We measured the neuromelanin-positive SNc region volume by manually contouring the high signal intensity region of the SNc on neuromelanin-sensitive MRI and measured the specific binding ratio (SBR) on DaTSCAN. The asymmetry index of neuromelanin-positive SNc volume and the asymmetry index of SBR were also calculated. The volume of the neuromelanin-positive SNc region showed significant correlation with specific binding ratio (SBR) (right P <.001, ρ = 0.78, left P <.001, ρ = 0.86). The asymmetry index of neuromelanin-positive SNc volume also showed significant correlations with the asymmetry index of SBR (P <.001, ρ = 0.73). Decrease of the high signal intensity region of the SNc on neuromelanin-sensitive MRI would indicate damage to the nigrostriatal dopaminergic function as well as loss of dopaminergic neurons. We conclude that neuromelanin-sensitive MRI is a useful diagnostic biomarker for parkinsonism. (orig.)

  5. SACSESS – the EURATOM FP7 project on actinide separation from spent nuclear fuels

    Directory of Open Access Journals (Sweden)

    Bourg Stéphane

    2015-12-01

    Full Text Available Recycling of actinides by their separation from spent nuclear fuel, followed by transmutation in fast neutron reactors of Generation IV, is considered the most promising strategy for nuclear waste management. Closing the fuel cycle and burning long-lived actinides allows optimizing the use of natural resources and minimizing the long-term hazard of high-level nuclear waste. Moreover, improving the safety and sustainability of nuclear power worldwide. This paper presents the activities striving to meet these challenges, carried out under the Euratom FP7 collaborative project SACSESS (Safety of Actinide Separation Processes. Emphasis is put on the safety issues of fuel reprocessing and waste storage. Two types of actinide separation processes, hydrometallurgical and pyrometallurgical, are considered, as well as related aspects of material studies, process modeling and the radiolytic stability of solvent extraction systems. Education and training of young researchers in nuclear chemistry is of particular importance for further development of this field.

  6. Nuclear β --decay half-lives for {fp} and {fpg} shell nuclei

    Science.gov (United States)

    Kumar, Vikas; Srivastava, P. C.; Li, Hantao

    2016-10-01

    In the present work we calculate the allowed {β }--decay half-lives of nuclei with Z=20-30 and N ≤slant 50 systematically under the framework of the nuclear shell model. A recent study shows that some nuclei in this region belong to the island of inversion. We perform calculation for fp shell nuclei using the KB3G effective interaction. In the case of Ni, Cu, and Zn, we used the JUN45 effective interaction. Theoretical results of Q values, half-lives, excitation energies, logft values, and branching fractions are discussed and compared with the experimental data. In the Ni region, we also compared our calculated results with recent experimental data (Xu et al 2014 Phys. Rev. Lett. 113 032505). The present results agree with the experimental data of half-lives in comparison to QRPA.

  7. 2nd FP7 Conference and International Summer School Nanotechnology : From Fundamental Research to Innovations

    CERN Document Server

    Yatsenko, Leonid

    2015-01-01

    This book presents some of the latest achievements in nanotechnology and nanomaterials from leading researchers in Ukraine, Europe, and beyond. It features contributions from participants in the 2nd International Summer School “Nanotechnology: From Fundamental Research to Innovations” and International Research and Practice Conference “Nanotechnology and Nanomaterials”, NANO-2013, which were held in Bukovel, Ukraine on August 25-September 1, 2013. These events took place within the framework of the European Commission FP7 project Nanotwinning, and were organized jointly by the Institute of Physics of the National Academy of Sciences of Ukraine, University of Tartu (Estonia), University of Turin (Italy), and Pierre and Marie Curie University (France). Internationally recognized experts from a wide range of universities and research institutions share their knowledge and key results on topics ranging from nanooptics, nanoplasmonics, and interface studies to energy storage and biomedical applications. Pr...

  8. Selected proceedings of the FP7 International Summer School Nanotechnology: From Fundamental Research to Innovations

    CERN Document Server

    Yatsenko, Leonid; Brodin, Mikhaylo; Nanomaterials imaging techniques, surface studies, and applications

    2013-01-01

    This book presents cutting-edge research on a wide range of nanotechnology techniques and applications.  It features contributions from scientists who participated in the International Summer School “Nanotechnology: From Fundamental Research to Innovations” in Bukovel, Ukraine on August 26 – September 2, 2012 funded by the European Commission FP7 project Nanotwinning implemented by the Institute of Physics of National Academy of Sciences of Ukraine and partner institutions: University of Tartu (Estonia), European Profiles A.E. (Greece), University of Turin (Italy) and Université Pierre et Marie Curie (France).  Worldwide experts present the latest results on such key topics as microscopy of nanostructures; nanocomposites; nanostructured interfaces and surfaces; nanooptics; nanoplasmonics; and enhanced vibrational spectroscopy.  Imaging technique coverage ranges from atomic force microscopy and spectroscopy, multiphoton imagery, and laser diagnostics of nanomaterials and nanostructures, to resonance ...

  9. Study on Commercial Application of FP-DSN Sulfur Transfer Additive in FCC Unit

    Institute of Scientific and Technical Information of China (English)

    Gao Siming; Han Rongxian; Chen Desheng

    2009-01-01

    The FCC unit with addition of various inventories of the FP-DSN type sulfur transfer additive was tested in a commercial scale. The effect of the sulfur transfer additive was analyzed by investigating the indicators related with the regenerator flue gas composition, the dry gas composition before desulfurization, the LPG composition before desulfurization, the acid gas, and the yield of gasoline and diesel. The test results indicated that the sulfur was trans-ferred fi'om the feed stream into the dry gas, LPG and acid gas, and the sulfur transfer effect was obvious only when the inventory of sulfur transfer additive exceeded over 2.0% of total FCC catalyst inventory.

  10. Spectroscopy of the odd-odd fp-shell nucleus 52Sc from secondary fragmentation

    CERN Document Server

    Gade, A; Brown, B A; Campbell, C M; Carpenter, M P; Cook, J M; Deacon, A N; Dinca, D C; Freeman, S J; Glasmacher, T; Janssens, R V F; Kay, B P; Mantica, P F; Müller, W F; Terry, J R; Zhu, S

    2006-01-01

    The odd-odd fp-shell nucleus 52Sc was investigated using in-beam gamma-ray spectroscopy following secondary fragmentation of a 55V and 57Cr cocktail beam. Aside from the known gamma-ray transition at 674(5)keV, a new decay at E_gamma=212(3) keV was observed. It is attributed to the depopulation of a low-lying excited level. This new state is discussed in the framework of shell-model calculations with the GXPF1, GXPF1A, and KB3G effective interactions. These calculations are found to be fairly robust for the low-lying level scheme of 52Sc irrespective of the choice of the effective interaction. In addition, the frequency of spin values predicted by the shell model is successfully modeled by a spin distribution formulated in a statistical approach with an empirical, energy-independent spin-cutoff parameter.

  11. [Contingencies of self-worth in Japanese culture: validation of the Japanese contingencies of self-worth scale].

    Science.gov (United States)

    Uchida, Yukiko

    2008-08-01

    The author developed a Japanese version of the Contingencies of Self-Worth Scale (CSWS) that was originally developed in the United States (Crocker, Luhtanen, Cooper, & Bouvrette, 2003). The Japanese version of the scale measures seven contingencies of self-esteem: Defeating others in competition, appearance, relationship harmony, other's approval, academic competence, virtue, and support of family and friends. Scores on the scale had systematic relationships with related variables, and the scale therefore exhibited satisfactory levels of construct validity: Relationship harmony, other's approval, and support of family and friends were positively correlated with sympathy and interdependence, whereas competitiveness was negatively correlated with sympathy. Moreover, competitiveness and academic achievement contingencies predicted competitive motivation, whereas the support of family and friends contingency predicted self-sufficient motivation. The scale has adequate test-retest reliability and a seven-factor structural model was confirmed. The implications for self-esteem and interpersonal relationships in Japanese culture are discussed.

  12. 基于磁盘表存储FP-TREE的关联规则挖掘算法%Mining Algorithm of Association Rules Based on Disk Table Resident FP-TREE

    Institute of Scientific and Technical Information of China (English)

    申彦; 宋顺林; 朱玉全

    2012-01-01

    随着现实待挖掘数据库规模不断增长,系统可使用的内存成为用FP-GROWTH算法进行关联规则挖掘的瓶颈.为了摆脱内存的束缚,对大规模数据库中的数据进行关联规则挖掘,基于磁盘的关联规则挖掘成为重要的研究方向.对此,改进原始的FP-TREE数据结构,提出了一种新颖的基于磁盘表的DTRFP-GROWTH (disk table resident FP-TREE growth)算法.该算法利用磁盘表存储FPTREE,降低内存使用,在传统FP-GROWTH算法占用过多内存、挖掘工作无法进行时,以独特的磁盘表存储FP-TREE技术,减少内存使用,能够继续完成挖掘工作,适合空间性能优先的场合.不仅如此,该算法还将关联规则挖掘和关系型数据库整合,克服了基于文件系统相关算法效率较低、开发难度较大等问题.在真实数据集上进行了验证实验以及性能分析.实验结果表明,在内存空间有限的情况下,DTRFP-GROWTH算法是一种有效的基于磁盘的关联规则挖掘算法.%As the size of the database to be mined is increasing constantly, the size of physical memory available has become a bottleneck when using FP-GROWTH algorithm for association rules mining. So. it is necessary to tackle space scalability by some new algorithms in order to mine association rules in huge database. Nowadays, disk-resident algorithm has become the main target. Therefore, the original data structure of FP-TREE is improved and a novel algorithm called DTRFP-GROWTH (disk table resident FP-TREE growth) is presented. This algorithm uses disk table for storing FP-TREE to decrease memory usage. When the mining works failed for FP-GROWTH using too much memory, DTRFP GROWTH can continue to mine association rules from huge database by its special skill called disk table resident FP-TREE, which is suitable to occasions of space performance priority. In addition, this algorithm also integrates association rules mining with RDBMS system. It overcomes the problems of

  13. 34 CFR 21.32 - Confidentiality of information about net worth.

    Science.gov (United States)

    2010-07-01

    ... established procedures under the Freedom of Information Act (34 CFR part 5). (Authority: 5 U.S.C. 504(c)(1)) ... 34 Education 1 2010-07-01 2010-07-01 false Confidentiality of information about net worth. 21.32... One Apply for an Award? § 21.32 Confidentiality of information about net worth. (a) In a proceeding...

  14. Is the Poor Performance of Self-Worth Protective Students Linked with Social Comparison Goals?

    Science.gov (United States)

    Thompson, Ted; Perry, Zoe

    2005-01-01

    Students motivated to protect self-worth perform poorly in situations that threaten to reveal low ability while performing well in situations that involve little threat to self-worth. One factor contributing to their poor performance is thought to be their orientation towards social comparison goals (goals that have to do with vindicating their…

  15. 75 FR 73964 - Safety Zone; USS Fort Worth Launch, Marinette, WI

    Science.gov (United States)

    2010-11-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; USS Fort Worth Launch, Marinette, WI AGENCY... launching of the USS Fort Worth in Marinette, WI. The Captain of the Port, Sector Lake Michigan,...

  16. Characteristic analysis of a novel F-P interferometer based on a pair of FBGs with built-in LPFGs

    Institute of Scientific and Technical Information of China (English)

    WANG Chun-bao; ZHANG Wei-gang; RUAN Juan; SHANG Jia-bin; YAN Ai-dong

    2012-01-01

    The transmission characteristics of a Fabry-Pérot (F-P) interferometer based on a fiber Bragg grating (FBG) pair with a built-in long-period fiber grating (LPFG) are theoretically analyzed,and the shift of transmission interference fringe as a function of environmental refractive index is acquired.The influence of the lengths of F-P cavity,LPFG and FBG on the transmission characteristics of the proposed interferometer has been numerically investigated,and the simulation results indicate that the sensitivity of refractive index reaches 2.27 × 10-6 for an optical spectrum analyzer (OSA) with a resolution of 1 pm.

  17. Seeing red: How perceptions of social status and worth influence hostile attributions and endorsement of aggression.

    Science.gov (United States)

    Davis, James R; Reyna, Christine

    2015-12-01

    Within social hierarchies, low social status is associated with increased vigilance, hostile expectations, and reactive aggression. We propose that societal devaluation is common across many low social status groups and produces a sense of threatened social worth. Threatened social worth may lead those of low status to be more vigilant towards social threats, thereby increasing the likelihood of hostile attributions and endorsement of aggression. Integrating theory on belongingness, social rejection, and stigma compensation, two studies test a sequential process model demonstrating that threatened social worth mediates the relationship between status, hostile attributions, and endorsement of aggression. Employing a relative status manipulation, Study 2 reveals a causal effect of status and highlights the importance of perceptions of low social status on threatened social worth. These data demonstrate the role of social worth in explaining the link between status and hostility and have implications for research in the social, health, and developmental domains.

  18. Do CSF levels of t-Tau, p-Tau and β{sub 1-42} amyloid correlate with dopaminergic system impairment in patients with a clinical diagnosis of Parkinson disease? A {sup 123}I-FP-CIT study in the early stages of the disease

    Energy Technology Data Exchange (ETDEWEB)

    Chiaravalloti, Agostino; Fiorentini, Alessandro; Lacanfora, Annamaria [University Tor Vergata, Department of Biomedicine and Prevention, Rome (Italy); Stefani, Alessandro [University Tor Vergata, Department of Neurosciences, Rome (Italy); IRCCS Santa Lucia, Rome (Italy); Stanzione, Paolo [University Tor Vergata, Department of Neurosciences, Rome (Italy); Schillaci, Orazio [University Tor Vergata, Department of Biomedicine and Prevention, Rome (Italy); IRCCS Neuromed, Pozzilli (Italy)

    2014-11-15

    To investigate the relationships among cerebrospinal fluid (CSF) levels of t-Tau, p-Tau and Aβ{sub 1-42} amyloid peptide and {sup 123}I-FP-CIT uptake. The study included 58 subjects (31 men and 27 women, age 67 ± 9 years) with a clinical diagnosis of Parkinson disease diagnosed according to the United Kingdom Parkinson Disease Society Brain Bank criteria. All subjects underwent a CSF assay 28 ± 3 days before {sup 123}I-FP-CIT SPECT scanning. The relationships were evaluated by means of linear regression analysis and Pearson correlation. Striatal {sup 123}I-FP-CIT was positively related to both t-Tau and p-Tau CSF values with low levels of t-Tau and p-Tau being related to a low uptake of {sup 123}I-FP-CIT. In particular, differences with higher statistical significance were found for the striatum between the contralateral side and the side mainly affected on clinical examination (P < 0.001). No significant relationships were found between Aβ{sub 1-42} amyloid peptide and {sup 123}I-FP-CIT binding. The results of our study suggest that the presynaptic dopaminergic system is more involved in Parkinson disease patients with lower t-Tau and p-Tau CSF values while values of Aβ{sub 1-42} amyloid peptide seems not to be related to nigrostriatal degeneration in our series. (orig.)

  19. Polychlorinated biphenyls in aquatic invertebrates and fish and observations about nitrogen and carbon isotope composition in relation to trophic structure and bioaccumulation patterns, Lake Worth and Meandering Road Creek, Fort Worth, Texas, 2007-08

    Science.gov (United States)

    Moring, J. Bruce

    2010-01-01

    During 2007-08 the U.S. Geological Survey, in cooperation with the U.S. Air Force, evaluated the concentration of polychlorinated biphenyls (PCBs) in aquatic invertebrates and fish from one site in the main body of Lake Worth, two sites in a small inlet in Lake Worth (upper and lower Woods Inlet), and one site in Meandering Road Creek in Fort Worth, Texas. The four sites sampled during 2007-08 were located at or near sites where surficial bed-sediment samples had been collected and analyzed for PCBs during previous U.S. Geological Survey studies so that PCB concentrations in aquatic invertebrates and fish and PCB concentrations in surficial bed-sediment samples could be compared. Stable nitrogen and carbon isotopes were used to help assess differences in the amount of these isotopes by species and sampling location. The sum of 15 PCB-congener concentrations was highest for aquatic invertebrates and fish from the upper Woods Inlet site and lowest for the same aquatic invertebrates and fish from Lake Worth site, where PCBs historically had not been detected in lake bed sediment. An increase in the ratio of the heavier nitrogen-15 (15N) isotope to the lighter nitrogen-14 (14N) isotope, referred to as enrichment of 15N, was highest in largemouth bass (representing the highest trophic level sampled) at all sites and lowest for true midge larvae inhabiting surficial bed sediment in the lake (representing the lowest trophic level sampled). Enrichment of 15N was less variable in largemouth bass and other fish from the highest trophic level compared with shorter lived, primary consumer invertebrates from lower trophic levels, such as true midge larvae, mayfly nymphs, and zooplankton. The delta carbon-13 (delta13C) values measured in true midge larvae collected at the Lake Worth and upper and lower Woods Inlet sites were more negative compared with the delta13C values measured for all other taxa, indicating true midge larvae were more depleted of carbon-13 (13C) compared

  20. 123I-FP-CIT SPECT imaging in early diagnosis of dementia in patients with and without a vascular component

    Directory of Open Access Journals (Sweden)

    Marina eGarriga

    2015-07-01

    Full Text Available Alzheimer’s disease (AD and vascular dementia (VaD are the most common cause of dementia. Cerebral ischemia is a major risk factor for development of dementia. 123I-FP-CIT SPECT (DaTScan is a complementary tool in the differential diagnoses of patients with incomplete or uncertain Parkinsonism. Additional application of DaTScan enables the categorization of Parkinsonian disease with dementia (PDD, and its differentiation from pure AD, and may further contribute to change the therapeutic decision. The aim of this study was to analyse the vascular contribution towards dementia and mild cognitive impairment (MCI. We evaluated the utility of DaTScan for the early diagnosis of dementia in patients with and without a clinical vascular component, and the association between neuropsychological function, vascular component and dopaminergic function on DaTScan. 105 patients with MCI or the initial phases of dementia were studied prospectively. We developed an initial assessment using neurologic examination, blood tests, cognitive function tests, structural neuroimaging and DaTScan. The vascular component was later quantified in two ways: clinically, according to the Framingham Risk Score and by structural neuroimaging using Wahlund Scale Total Score (WSTS. Early diagnosis of dementia was associated with an abnormal DaTScan. A significant association was found between a high WSTS and an abnormal DaTScan (p<0.01. Mixed AD was the group with the highest vascular component, followed by the VaD group, while MCI and pure AD showed similar WSTS. No significant associations were found between neuropsychological impairment and DaTScan independently of associated vascular component. DaTScan seems to be a good tool to discriminate, in a first clinical assessment, patients with MCI from those with established dementia. There was bigger general vascular affectation observable in MRI or CT in patients with abnormal dopaminergic uptake seen on DaTScan.

  1. Calibration of gamma camera systems for a multicentre European {sup 123}I-FP-CIT SPECT normal database

    Energy Technology Data Exchange (ETDEWEB)

    Tossici-Bolt, Livia [Southampton Univ. Hospitals NHS Trust, Dept. of Medical Physics and Bioengineering, Southampton (United Kingdom); Dickson, John C. [UCLH NHS Foundation Trust and Univ. College London, Institute of Nuclear Medicine, London (United Kingdom); Sera, Terez [Univ. of Szeged, Dept. of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Nijs, Robin de [Rigshospitalet and Univ. of Copenhagen, Neurobiology Research Unit, Copenhagen (Denmark); Bagnara, Maria Claudia [Az. Ospedaliera Universitaria S. Martino, Medical Physics Unit, Genoa (Italy); Jonsson, Cathrine [Karolinska Univ. Hospital, Dept. of Nuclear Medicine, Medical Physics, Stockholm (Sweden); Scheepers, Egon [Univ. of Amsterdam, Dept. of Nuclear Medicine, Academic Medical Centre, Amsterdam (Netherlands); Zito, Felicia [Fondazione IRCCS Granda, Ospedale Maggiore Policlinico, Dept. of Nuclear Medicine, Milan (Italy); Seese, Anita [Univ. of Leipzig, Dept. of Nuclear Medicine, Leipzig (Germany); Koulibaly, Pierre Malick [Univ. of Nice-Sophia Antipolis, Nuclear Medicine Dept., Centre Antoine Lacassagne, Nice (France); Kapucu, Ozlem L. [Gazi Univ., Faculty of Medicine, Dept. of Nuclear Medicine, Ankara (Turkey); Koole, Michel [Univ. Hospital and K.U. Leuven, Nuclear Medicine, Leuven (Belgium); Raith, Maria [Medical Univ. of Vienna, Dept. of Nuclear Medicine, Vienna (Austria); George, Jean [Univ. Catholique Louvain, Nuclear Medicine Division, Mont-Godinne Medical Center, Mont-Godinne (Belgium); Lonsdale, Markus Nowak [Bispebjerg Univ. Hospital, Dept. of Clinical Physiology and Nuclear Medicine, Copenhagen (Denmark); Muenzing, Wolfgang [Univ. of Munich, Dept. of Nuclear Medicine, Munich (Germany); Tatsch, Klaus [Univ. of Munich, Dept. of Nuclear Medicine, Munich (Germany); Municipal Hospital of Karlsruhe Inc., Dept. of Nuclear Medicine, Karlsruhe (Germany); Varrone, Andrea [Center for Psychiatric Research, Karolinska Inst., Dept. of Clinical Neuroscience, Stockholm (Sweden)

    2011-08-15

    A joint initiative of the European Association of Nuclear Medicine (EANM) Neuroimaging Committee and EANM Research Ltd. aimed to generate a European database of [{sup 123}I]FP-CIT single photon emission computed tomography (SPECT) scans of healthy controls. This study describes the characterization and harmonization of the imaging equipment of the institutions involved. {sup 123}I SPECT images of a striatal phantom filled with striatal to background ratios between 10:1 and 1:1 were acquired on all the gamma cameras with absolute ratios measured from aliquots. The images were reconstructed by a core lab using ordered subset expectation maximization (OSEM) without corrections (NC), with attenuation correction only (AC) and additional scatter and septal penetration correction (ACSC) using the triple energy window method. A quantitative parameter, the simulated specific binding ratio (sSBR), was measured using the ''Southampton'' methodology that accounts for the partial volume effect and compared against the actual values obtained from the aliquots. Camera-specific recovery coefficients were derived from linear regression and the error of the measurements was evaluated using the coefficient of variation (COV). The relationship between measured and actual sSBRs was linear across all systems. Variability was observed between different manufacturers and, to a lesser extent, between cameras of the same type. The NC and AC measurements were found to underestimate systematically the actual sSBRs, while the ACSC measurements resulted in recovery coefficients close to 100% for all cameras (AC range 69-89%, ACSC range 87-116%). The COV improved from 46% (NC) to 32% (AC) and to 14% (ACSC) (p < 0.001). A satisfactory linear response was observed across all cameras. Quantitative measurements depend upon the characteristics of the SPECT systems and their calibration is a necessary prerequisite for data pooling. Together with accounting for partial volume, the

  2. FP-PSO算法在认知无线电频谱分配上的应用研究%The application research on cognitive radio spectrum allocation based FP-PSO algorithm

    Institute of Scientific and Technical Information of China (English)

    刘俊霞; 卞琛

    2016-01-01

    针对认知无线电频谱分配时分配率低、用户满意度不高的问题,提出了适应值预测的粒子群优化算法(FPPSO),利用FP-PSO 算法优化了认知无线电频谱分配过程,设计的适应值预测方法提高了分配效率的同时满足了实时性要求。实验结果表明:FP-PSO 算法在降低部分网络效益的同时,获得了比颜色敏感图着色算法(CSGC)更优的用户满意度、平均分配时间和用户公平性。%As distribution rate and customer satisfaction were not high in the process of the spectrum allocation for cognitive radio, Fitness Prediction of Particle Swarm Optimization (FP-PSO) was proposed , using FP-PSO algorithm to optimize the cognitive radio spectrum allocation process , fitness prediction methods is designed to improve the allocation efficiency while meeting the real-time requirements. The experimental results showed that: FP-PSO algorithm reduced a part of network bandwidth benefit, at the same user satisfaction, allocation efficiency, the average assignment time and the user fairness are better than the color sensitive graph coloring algorithm (CSGC).

  3. 基于有序FP-tree的最大长度频繁项集挖掘算法%Algorithm for mining maximal length frequent itemsets based on order FP-tree

    Institute of Scientific and Technical Information of China (English)

    廖福蓉; 王成良

    2012-01-01

    频繁项集的挖掘受到大量候选频繁项集和较高计算花费的限制,只挖掘最大长度频繁项集已满足很多应用.提出一种基于有序FP-tree结构挖掘最大长度频繁项集的算法.即对有序FP-tree的头表进行改造,增加一个max-level域,记录该项在有序FP-tree中的最大高度.挖掘时仅对max-level大于等于已有最大长度频繁项集长度的项进行遍历,不产生条件模式基,无需递归构造条件FP-tree,且计算出最大长度频繁项集的支持度.实验结果表明该算法挖掘效率高、速度快.%The mining of frequent itemsets has been limited by the large number of resulting itemsets as well as the high computational cost. In many application domains, however, it is often sufficient to mine maximum length frequent itemsets. An order FP-tree-based algorithm is proposed for the mining problem. A field max-level is added in head-table to record the greatest height of item. In the mining process, only the item which max-level value is equal or greater than the length of existing maximum length frequent itemsets is traversed. Neither producing conditional pattern base nor constructing conditional frequent pattern tree recursively is needed, and the support of maximum length frequent itemsets is calculated. The experimental results show that the algorithm accelerates the speed to traverse the tree and improves the mining efficiency.

  4. Recommendations for the spatial assessment of air quality resulting from the FP6 EU project Air4EU

    NARCIS (Netherlands)

    Denby, B.; Larssen, S.; Builtjes, P.; Keuken, M.; Sokhi, R.; Moussiopoulos, N.; Douros, J.; Borrego, C.; Costa, A.M.; Pregger, T.

    2011-01-01

    Air4EU is an FP6 European project with the major aim of providing recommendations on methodologies for the spatial assessment of air quality on local, urban and regional scales. The emphasis is on methodologies that combine monitoring and modelling and on spatial assessment for regulatory purposes,

  5. Calibration of gamma camera systems for a multicentre European ¹²³I-FP-CIT SPECT normal database

    DEFF Research Database (Denmark)

    Tossici-Bolt, Livia; Dickson, John C; Sera, Terez

    2011-01-01

    A joint initiative of the European Association of Nuclear Medicine (EANM) Neuroimaging Committee and EANM Research Ltd. aimed to generate a European database of [(123)I]FP-CIT single photon emission computed tomography (SPECT) scans of healthy controls. This study describes the characterization...

  6. Social Franchising: A Blockbuster to Address Unmet Need for Family Planning and to Advance Toward the FP2020 Goal.

    Science.gov (United States)

    2015-06-17

    Social franchising has scaled-up provision of voluntary family planning, especially long-acting reversible contraceptives, across Africa and Asia at a rapid and remarkable pace. The approach should be pursued vigorously, especially in countries with a significant private-sector presence, to advance the FP2020 goal of providing access to modern contraception to 120 million additional clients by 2020.

  7. Impact of fowlpox-vectored Mycoplasma gallisepticum vaccine Vectormune FP MG on layer hen egg production and egg quality parameters.

    Science.gov (United States)

    Leigh, S A; Branton, S L; Evans, J D; Collier, S D

    2013-12-01

    This study was conducted to determine the impact of vaccination with Vectormune FP MG on egg production and egg quality characteristics of Single Comb White Leghorn hens. Due to questions of the efficacy of this vaccine in preventing Mycoplasma gallisepticum-mediated pathology, the ability of this vaccine to protect against postproduction-peak egg losses associated with F-strain M. gallisepticum (FMG) vaccination was also investigated. Vaccination with Vectormune FP MG did not result in any significant change in egg production or egg quality parameters compared with control (unvaccinated) hens. Subsequent revaccination with FMG at 45 wk of age (woa) yielded no impact on egg production or egg quality parameters of Vectormune FP MG vaccinated hens, unlike prior results for postproduction-peak vaccination of M. gallisepticum-clean hens with FMG, which exhibited a drop in egg production of approximately 6%. No difference in egg size distribution was observed for any of the treatment groups before or after FMG revaccination. These results suggest that hens can be safely vaccinated with Vectormune FP MG as pullets and can be revaccinated with a live M. gallisepticum vaccine such as FMG at a later date with no deleterious effects on egg production or egg or eggshell quality parameters.

  8. [Global lessons of Minamata disease--a man's worth].

    Science.gov (United States)

    Harada, Masazumi

    2009-02-01

    Minamata disease (MD) was first recognized in May 1956. Its first recognized victims were 3 and 5 years old children. Environmental contamination most rapidly and seriously affected the physiologically and socially weak among the residents. Methylmercury (MeHg) had accumulated in fishes and shellfishes and those who ate them had been poisoning with it. MD is an indirect poisoning by MeHg through the food chain as a result of environmental contamination, and is the first known disease to cause abnormalities in the fetus due to a toxic substances passing through the placenta. In 1962 MeHg poisoning through the placenta was found for the first time in the world. It used to be considered that poisoning was caused by direct exposure to a toxic substance, and that toxic substances did not pass the placenta. MD had implications in various fields. Namely it also stirred up legal, ethical, and eugenic arguments concerning fetal protection. Also man thought about a man's worth.

  9. Experiments and analyses on reactivity worth of gas expansion module (GEM) in FCA XX-1. Joint research

    Energy Technology Data Exchange (ETDEWEB)

    Oigawa, Hiroyuki; Andoh, Masaki; Iijima, Susumu [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Takaki, Naoyuki; Uematsu, Mari Marianne [The Japan Atomic Power Company, Tokyo (Japan)

    2001-06-01

    Gas Expansion Module (GEM) will be installed in large scale fast reactors in order to insert negative reactivity feedback in a transition of the primary pump trip. A mock-up experiment was performed at the XX-1 core of the Fast Critical Assembly (FCA) to evaluate and improve the prediction accuracy of the reactivity effect inserted by the GEM (GEM reactivity worth). The GEM was categorized into 'External GEM' and 'In-core GEM' according to its position; the experiment was performed for both cases, and the prediction accuracy was discussed. As for the external GEM reactivity worth, it was indicated that the self-shielding effect for iron used as the structural material of the GEM should be taken into account in the preparation process of the effective cross section of the GEM region. The overestimation of 10-20% was observed when the deterministic calculation was adopted for the transport correction in RZ geometry. When the Monte-Carlo method was used instead, the overestimation was reduced below 10%. As for the in-core GEM reactivity worth, it was pointed out that the cell homogenization should be carefully carried out since the neutron streaming affects the prediction accuracy. The prediction accuracy shows a dependence on the sodium level in the GEM. The prediction accuracy was evaluated by separating it into the non-leakage term and the leakage term by a least-squares fitting. It was found that the non-leakage term shows 10-20% overestimation, while the leakage term agrees well with the measurement within the experimental error. (author)

  10. Calculation of RABBIT and Simulator Worth in the HFIR Hydraulic Tube and Comparison with Measured Values

    Energy Technology Data Exchange (ETDEWEB)

    Slater, CO

    2005-09-08

    To aid in the determinations of reactivity worths for target materials in a proposed High Flux Isotope Reactor (HFIR) target configuration containing two additional hydraulic tubes, the worths of cadmium rabbits within the current hydraulic tube were calculated using a reference model of the HFIR and the MCNP5 computer code. The worths were compared to measured worths for both static and ejection experiments. After accounting for uncertainties in the calculations and the measurements, excellent agreement between the two was obtained. Computational and measurement limitations indicate that accurate estimation of worth is only possible when the worth exceeds 10 cents. Results indicate that MCNP5 and the reactor model can be used to predict reactivity worths of various samples when the expected perturbations are greater than 10 cents. The level of agreement between calculation and experiment indicates that the accuracy of such predictions would be dependent solely on the quality of the nuclear data for the materials to be irradiated. Transients that are approximated by ''piecewise static'' computational models should likewise have an accuracy that is dependent solely on the quality of the nuclear data.

  11. The direct and indirect role of self esteem and procrastination in the relation to fear of failure and self worth

    Directory of Open Access Journals (Sweden)

    Murat Balkıs

    2012-09-01

    Full Text Available The aim of this study was to investigate the direct and indirect role of self esteem and procrastination in the relation between fear of failure and self worth. The participants were 279 students who study different major fields at the Faculty of Education in Pamukkale University. Age range varied from 19 to 34. In this study, Tuckman Procrastination Inventory, Rosenberg Self Esteem Inventory, Activate and Success Based Self Worth Scale, Concern over Mistakes Scale and Personal Information Sheet were used to gather data. Results showed that procrastination had partial mediating effect in relation to fear of failure; performance based self worth, and self worth vulnerability. In other words, the effect of fear of failure on the performance based self worth and self worth vulnerability was decreased when procrastination was added the equation. The results also showed that self esteem had partial mediating role in relation to fear of failure-procrastination, fear of failure- performance based self worth, and self worth vulnerability. In other words, the effect of fear of failure on the procrastination, performance based self worth, and self worth vulnerability was reduced, when self esteem was added the equation. Finally, results showed that self esteem had full mediating role in the relation to procrastination; performance based self worth, and self worth vulnerability. Implications of these findings are discussed and suggestions are presented within the context of literature.

  12. The direct and indirect role of self esteem and procrastination in the relation to fear of failure and self worth

    Directory of Open Access Journals (Sweden)

    Murat Balkıs

    2012-09-01

    Full Text Available The aim of this study was to investigate the direct and indirect role of self esteem and procrastination in the relation between fear of failure and self worth.  The participants were 279 students who study different major fields at the Faculty of Education in Pamukkale University. Age range varied from 19 to 34. In this study, Tuckman Procrastination Inventory, Rosenberg Self Esteem Inventory, Activate and Success Based Self Worth Scale, Concern over Mistakes Scale and Personal Information Sheet were used to gather data. Results showed that procrastination had partial mediating effect in relation to fear of failure; performance based self worth, and self worth vulnerability. In other words, the effect of fear of failure on the performance based self worth and self worth vulnerability was decreased when procrastination was added the equation. The results also showed that self esteem had partial mediating role in relation to fear of failure-procrastination, fear of failure- performance based self worth, and self worth vulnerability. In other words, the effect of fear of failure on the procrastination, performance based self worth, and self worth vulnerability was reduced, when self esteem was added the equation. Finally, results showed that self esteem had full mediating role in the relation to procrastination; performance based self worth, and self worth vulnerability. Implications of these findings are discussed and suggestions are presented within the context of literature.

  13. The discriminating nature of dopamine transporter image in parkinsonism: the competency of dopaminergic transporter imaging in differential diagnosis of parkinsonism {sup 123}I-FP-CIT SPECT study

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bom Sahn; Jang, Sung June; Eo, Jae Seon; Park, Eun Kyung; Kim, Yu Kyeong; Kim, Jong Min; Lee, Won Woo; Kim, Sang Eun [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2007-08-15

    The aim of this study was to evaluate the discriminating nature of {sup 123}I-FP-CIT SPECT in patients with parkinsonism. {sup 123}I-FP-CIT SPECT images acquired from the 18 normal controls; NC (60.4 {+-} 10.0 yr) and 237 patients with parkinsonism (65.9 {+-} 9.2 yr) were analyzed. From spatially normalized images, regional counts of the caudate, putamen, and occipital lobe were obtained using region of interest method. Binding potential (BP) was calculated with the ratio of specific to nonspecific binding activity at equilibrium. Additionally, the BP ratio of putamen to caudate (PCR) and asymmetric index (ASI) were measured. BPs of NC (3.37 {+-} 0.57, 3.10{+-} 0.41, 3.23 {+-} 0.48 for caudate, putamen, whole striatum, respectively) had no significant difference with those of essential tremor; ET (3.31 {+-} 0.64, 3.06 {+-} 0.61, 3.14 {+-} 0.63) and Alzheimer's disease; AD (3.33 {+-} 0.60, 3.29 {+-} 0.79, 3.31 {+-} 0.70), but were higher than those of Parkinson's disease; PD (1.92 {+-} 0.74, 1.39 {+-}0.68, 1.64 {+-} 0.68), multiple system atrophy; MSA (2.36 {+-} 1.07, 2.16 {+-} 0.91, 2.26 {+-} 0.96), and dementia with Lewy body; DLB (1.95{+-} 0.72, 1.64 {+-} 0.65, 1.79 {+-} 0.66)({rho} < 0.005). PD had statistically lower values of PCR and higher values of ASI than those of NC ({rho} < 0.005). And PD had significantly lower value of PCR, higher ASI and lower BP in the putamen and whole striatum than MSA ({rho} < 0.05). Dopamine transporter image of {sup 123}I-FP-CIT SPECT was a good value in differential diagnosis of parkinsonism.

  14. Initiating or changing to a fixed-dose combination of Fluticasone propionate/Formoterol over Fluticasone propionate/Salmeterol: A real-life effectiveness and cost impact evaluation.

    Science.gov (United States)

    Wan Yau Ming, Simon; Haughney, John; Small, Iain; Wolfe, Stephanie; Hamill, John; Gruffydd-Jones, Kevin; Daly, Cathal; Soriano, Joan B; Gardener, Elizabeth; Skinner, Derek; Stagno d'Alcontres, Martina; Price, David B

    2017-08-01

    Asthma has a substantial impact on quality of life and health care resources. The identification of a more cost-effective, yet equally efficacious, treatment could positively influence the economic burden of this disease. Fluticasone propionate/Formoterol (FP/FOR) may be as effective as Fluticasone Salmeterol (FP/SAL). We evaluated non-inferiority of asthma control in terms of the proportion of patients free from exacerbations, and conducted a cost impact analysis. This historical, matched cohort database study evaluated two treatment groups in the Optimum Patient Care Research Database in the UK: 1) an FP/FOR cohort of patients initiating treatment with FP/FOR or changing from FP/SAL to FP/FOR and; 2) an FP/SAL cohort comprising patients initiating, or remaining on FP/SAL pMDI combination therapy. The main outcome evaluated non-inferiority of effectiveness (defined as prevention of severe exacerbations, lower limit of the 95% confidence interval (CI) of the mean difference between groups in patient proportions with no exacerbations is -3.5% or higher) in patients treated with FP/FOR versus FP/SAL. After matching 1:3, we studied a total of 2472 patients: 618 in the FP/FOR cohort (174 patients initiated on FP/FOR and 444 patients changed to FP/FOR) and 1854 in the FP/SAL cohort (522 patients initiated FP/SAL and 1332 continued FP/SAL). The percentage of patients prescribed FP/FOR met non-inferiority as the adjusted mean difference in proportion of no severe exacerbations (95%CI) was 0.008 (-0.032, 0.047) between the two cohorts. No other significant differences were observed except acute respiratory event rates, which were lower for patients prescribed FP/FOR (rate ratio [RR] 0.82, 95% CI 0.71, 0.94). Changing to, or initiating FP/FOR combination therapy, is associated with a non-inferior proportion of patients who are severe exacerbation-free at a lower average annual cost compared with continuing or initiating treatment with FP/SAL. Copyright © 2017 Elsevier Ltd

  15. FP7 HBB-Next, a proposal for a European 7th Framework Project on next-generation Hybrid Broadcast Broadband

    NARCIS (Netherlands)

    Deventer, M.O. van; Niamut, O.A.

    2011-01-01

    This is the FP7 proposal HBB-Next: Next-Generation Hybrid Broadcast Broadband. It was submitted on 18 January 2011 for FP7 call no.7, objective 1.5a. So far, Hybrid Broadcast Internet applications have only linked Internet and broadcast content by offering over‐the‐top On‐Demand content in addition

  16. FP7 HBB-Next, a proposal for a European 7th Framework Project on next-generation Hybrid Broadcast Broadband

    NARCIS (Netherlands)

    Deventer, M.O. van; Niamut, O.A.

    2011-01-01

    This is the FP7 proposal HBB-Next: Next-Generation Hybrid Broadcast Broadband. It was submitted on 18 January 2011 for FP7 call no.7, objective 1.5a. So far, Hybrid Broadcast Internet applications have only linked Internet and broadcast content by offering over‐the‐top On‐Demand content in addition

  17. Performance of 6FDA–6FpDA polyimide for propylene/propane separations

    KAUST Repository

    Das, Mita

    2010-12-01

    This work addresses the challenges faced by previous researchers with 6FDA-6FpDA polyimide for propylene/propane separations due to plasticization. A study of film annealing temperature is reported to optimize plasticization suppression in elevated temperature permeation on properly annealed dense films made with high molecular weight polymer. A detailed analysis of pure and mixed gas results using different permeability models is shown in this work. The annealing effects in terms of plasticization suppression and permeability and selectivity changes are discussed in detail. According to our best knowledge, this is for the first time plasticization suppression for propylene/propane has been reported with any polyimide dense film membrane. Results of pure gas sorption experiments using a pressure decay method with un-annealed and annealed films are discussed and used to analyze the permeation data using the dual-mode model. Mixed gas permeation results also are explained with dual mode and bulk flow transport models. © 2010 Elsevier B.V.

  18. APhoRISM FP7 project: the Multi-platform volcanic Ash Cloud Estimation (MACE) infrastructure

    Science.gov (United States)

    Merucci, Luca; Corradini, Stefano; Bignami, Christian; Stramondo, Salvatore

    2014-05-01

    APHORISM is an FP7 project that aims to develop innovative products to support the management and mitigation of the volcanic and the seismic crisis. Satellite and ground measurements will be managed in a novel manner to provide new and improved products in terms of accuracy and quality of information. The Multi-platform volcanic Ash Cloud Estimation (MACE) infrastructure will exploit the complementarity between geostationary, and polar satellite sensors and ground measurements to improve the ash detection and retrieval and to fully characterize the volcanic ash clouds from source to the atmosphere. The basic idea behind the proposed method consists to manage in a novel manner, the volcanic ash retrievals at the space-time scale of typical geostationary observations using both the polar satellite estimations and in-situ measurements. The typical ash thermal infrared (TIR) retrieval will be integrated by using a wider spectral range from visible (VIS) to microwave (MW) and the ash detection will be extended also in case of cloudy atmosphere or steam plumes. All the MACE ash products will be tested on three recent eruptions representative of different eruption styles in different clear or cloudy atmospheric conditions: Eyjafjallajokull (Iceland) 2010, Grimsvotn (Iceland) 2011 and Etna (Italy) 2011-2012. The MACE infrastructure will be suitable to be implemented in the next generation of ESA Sentinels satellite missions.

  19. APhoRISM FP7 project: the A Priori information for Earthquake damage mapping method

    Science.gov (United States)

    Bignami, Christian; Stramondo, Salvatore; Pierdicca, Nazzareno

    2014-05-01

    The APhoRISM - Advanced PRocedure for volcanIc and Seismic Monitoring - project is an FP7 funded project, which aims at developing and testing two new methods to combine Earth Observation satellite data from different sensors, and ground data for seismic and volcanic risk management. The objective is to demonstrate that this two types of data, appropriately managed and integrated, can provide new improved products useful for seismic and volcanic crisis management. One of the two methods deals with earthquakes, and it concerns the generation of maps to address the detection and estimate of damage caused by a seism. The method is named APE - A Priori information for Earthquake damage mapping. The use of satellite data to investigate earthquake damages is not an innovative issue. Indeed, a wide literature and projects have addressed and focused such issue, but usually the proposed approaches are only based on change detection techniques and/or classifications algorithms. The novelty of APhoRISM-APE relies on the exploitation of a priori information derived by: - InSAR time series to measure surface movements - shakemaps obtained from seismological data - vulnerability information. This a priori information is then integrated with change detection map from earth observation satellite sensors (either Optical or Synthetic Aperture Radar) to improve accuracy and to limit false alarms.

  20. The ULISSE FP7 project new system for data exploration and dissemination

    Science.gov (United States)

    Carotenuto, Luigi; Rothkaehl, Hanna; Berthier, Audrey; Słomińska, Ewa

    2010-05-01

    The ULISSE FP7 project is aimed at providing the users with tools for improving data valorisation and exploitation of European space science experimentation. The activities are aimed at increasing the involvement of specialized communities and the awareness of general public.ULISSE will provide scientific and technical data concerning most scientific disciplines, as Life Sciences including Space Medicine and Exobiology, Biotechnology, Material and Fluid Sciences, Space Science. Data that will be available through ULISSE concern previous space experiments on ISS as well as data from other space platforms, like sounding rockets, Foton capsule, Space Shuttle, etc. This dataset, coming from a wide ensemble of experiments, represents a relevant resource that ULISSE brings to a new life, exploited for testing and demonstrative purposes. A relevant part of the project foresees that data, services and tools are integrated through the ULISSE middleware platform, developing a distributed infrastructure for the distribution of the scientific data coming from space experiments. ULISSE expected benefits maximise the return from scientific space missions by maximizing the exploitation of available data and preparing the exploitation of future space mission and increase the public awareness about space research results and benefits involving a wider community also including educational bodies. The aim of this presentation is also to show the survey of space physics experiments performed on ISS.

  1. EGIDA FP7 European Project: Outcomes of the National Use Cases Workshop

    Science.gov (United States)

    Mazzetti, P.; Bonora, N.; McCallum, I.; Nativi, S.

    2011-12-01

    In the framework of the EGIDA Project (European Commission FP7), that aims to support the implementation of the GEOSS Science and Technology roadmap, a workshop was held for the identification and analysis of European National contributions across a wide range of GEOSS SBAs (Social Benefit Areas), characterised through a bottom-up approach to GEOSS. During the workshop organization phase it was decided to address the activities not only to the identification of further examples showcasing GEOSS at work, but also to provide to the European Commission and GEOSS: a) elements to improve the national/regional contribution to GEOSS; b) elements to make the national contribution sustainable; and c) practices, commonalities and needs for further replication processes. The workshop collected 17 contributions from various European research institutes, programmes, projects and academia. The results of the workshop have been analysed in terms of practices, commonalities and needs, and they have been grouped into nine issues, such as: a) organising & catalysing resources, b) reuse and replication, c) promote data sharing, d) raise awareness for changing culture, e) ICT supporting activities & knowledge transfer, f) national GEO implementation & also governance, g) quick wins, h) scientific engagement in GEOSS and i) possible improvement of GEOSS at the EU level.

  2. FP/FIFO scheduling: coexistence of deterministic and probabilistic QoS guarantees

    Directory of Open Access Journals (Sweden)

    Pascale Minet

    2007-01-01

    Full Text Available In this paper, we focus on applications having quantitative QoS (Quality of Service requirements on their end-to-end response time (or jitter. We propose a solution allowing the coexistence of two types of quantitative QoS garantees, deterministic and probabilistic, while providing a high resource utilization. Our solution combines the advantages of the deterministic approach and the probabilistic one. The deterministic approach is based on a worst case analysis. The probabilistic approach uses a mathematical model to obtain the probability that the response time exceeds a given value. We assume that flows are scheduled according to non-preemptive FP/FIFO. The packet with the highest fixed priority is scheduled first. If two packets share the same priority, the packet arrived first is scheduled first. We make no particular assumption concerning the flow priority and the nature of the QoS guarantee requested by the flow. An admission control derived from these results is then proposed, allowing each flow to receive a quantitative QoS guarantee adapted to its QoS requirements. An example illustrates the merits of the coexistence of deterministic and probabilistic QoS guarantees.

  3. Comparison of LECO FP-228 "nitrogen determinator" with AOAC copper catalyst Kjeldahl method for crude protein.

    Science.gov (United States)

    Sweeney, R A; Rexroad, P R

    1987-01-01

    The LECO FP-228 "Nitrogen Determinator" was compared with the AOAC copper catalyst Kjeldahl method, 7.033-7.037, for the determination of crude protein in feed materials. The completely microprocessor-controlled instrument determines nitrogen by measuring the nitrogen gas following combustion of the sample; it was easy to operate and broadly applicable. A wide variety of feed materials of various nitrogen levels were analyzed in one mixed sequence. Results were precise, accurate, and rapid. Analysis time for one sample was approximately 3 min. Fourteen samples containing 2.5-15.5% N were selected for study and consisted of meals, grains, forages, and standard organic materials. The overall mean for the 14 samples by the LECO combustion method was 8.61% N compared with an overall mean of 8.58% N for the AOAC Kjeldahl method. Within-sample standard deviations for the LECO combustion method ranged from 0.013 to 0.052% N with a pooled standard deviation (SD) of 0.033% N for the 14 samples. Standard deviations for the AOAC Kjeldahl method ranged from 0.006 to 0.035% N with a pooled SD of 0.022% N. Combined average recovery of nitrogen from tryptophan, lysine-HCl, and EDTA determined by the LECO combustion method was 99.94% compared to 99.88% determined by the AOAC Kjeldahl method.

  4. The severe accident research programme PHEBUS F.P.: First results and future tests

    Energy Technology Data Exchange (ETDEWEB)

    Schwarz, M. [Institut de Protection et de Surete Nucleaire IPSN, Saint Paul Lez Durance (France); Hardt, P. von der [Joint Research Centre - Safety Technology Institute, Saint Paul Lez Durance (France)

    1996-03-01

    PHEBUS FP is an international programme, managed by the French Institut de Protection et de Surete Nucleaire, Electricite de France and the European Commission in close collaboration with the USNRC (US), COG (Canada), NUPEC and JAERI (Japan) and KAERI (South Korea). Its objective is to investigate through a series of in-pile integral experiments, key phenomena involved in LWR severe accident such as the degradation of core materials up to molten pool, the subsequent release of fission products and of structural materials, their transport in the cooling system and their deposition in the containment with a special emphasis on the volatility of iodine. After a general programme description, the paper focuses on the status of analysis of the first test FPT-0, which involved trace irradiated fuel and which has shown some quite unexpected results regarding fuel degradation and iodine behaviour, and on the upcoming test FPT-1 which will use irradiated fuel. The status of the preparation of the remaining tests of the programme is also presented.

  5. Data on occurrence of selected trace metals, organochlorines, and semivolatile organic compounds in edible fish tissues from Lake Worth, Fort Worth, Texas, 1999

    Science.gov (United States)

    Moring, J. Bruce

    2002-01-01

    A public-health assessment conducted for the Texas Department of Health and the Agency for Toxic Substances and Disease Registry concluded that exposure to contaminants through the aquatic food chain is an indeterminate human-health hazard in Lake Worth, Fort Worth, Texas. In 1999, the U.S. Geological Survey, in cooperation with the U.S. Air Force and in collaboration with the Texas Department of Health, collected samples of edible fish tissues from Lake Worth for analysis of selected trace metals, organochlorines, and semivolatile organic compounds to support a human-health risk assessment. Left-side, skin-off fillet samples were collected from 10 individuals each of channel catfish, common carp, freshwater drum (gaspergou), largemouth bass, and white crappie but only from five smallmouth buffalo. The U.S. Geological Survey National Water Quality Laboratory analyzed the samples for 22 trace metals, 40 organochlorine pesticides and polychlorinated biphenyls, and 75 semivolatile organic compounds.

  6. A robust computational solution for automated quantification of a specific binding ratio based on [123i]fp-cit SPECT images.

    Science.gov (United States)

    Oliveira, F P M; Borges Faria, D; Campos Costa, D; Tavares, J M R S

    2014-03-01

    The purpose of the current paper is to present a computational solution to accurately quantify a specific to a non-specific uptake ratio in [123I]fP-CIT single photon emission computed tomography (SPECT) images and simultaneously measure the spatial dimensions of the basal ganglia, also known as basal nuclei. A statistical analysis based on a reference dataset selected by the user is also automatically performed. The quantification of the specific to non-specific uptake ratio here is based on regions of interest defined after the registration of the image under study with a template image. The computational solution was tested on a dataset of 38 [123I]FP-CIT SPECT images: 28 images were from patients with Parkinson's disease and the remainder from normal patients, and the results of the automated quantification were compared to the ones obtained by three well-known semi-automated quantification methods. The results revealed a high correlation coefficient between the developed automated method and the three semi-automated methods used for comparison (r ≥0.975). The solution also showed good robustness against different positions of the patient, as an almost perfect agreement between the specific to non-specific uptake ratio was found (ICC=1.000). The mean processing time was around 6 seconds per study using a common notebook PC. The solution developed can be useful for clinicians to evaluate [123I]FP-CIT SPECT images due to its accuracy, robustness and speed. Also, the comparison between case studies and the follow-up of patients can be done more accurately and proficiently since the intra- and inter-observer variability of the semi-automated calculation does not exist in automated solutions. The dimensions of the basal ganglia and their automatic comparison with the values of the population selected as reference are also important for professionals in this area.

  7. Prometheus unbound: A study of the Dallas/Fort Worth Regional Airport. [Socio-economic considerations

    Science.gov (United States)

    Starling, J. D.; Brown, J.; Dominus, M. I.

    1975-01-01

    The history of the controversies in the development of the Dallas/Fort Worth Regional Airport is detailed. Present technological and organizational management problems are outlined. Maps and illustrations are included.

  8. 12 CFR 702.106 - Standard calculation of risk-based net worth requirement.

    Science.gov (United States)

    2010-01-01

    ... AFFECTING CREDIT UNIONS PROMPT CORRECTIVE ACTION Net Worth Classification § 702.106 Standard calculation of...) Allowance. Negative one hundred percent (−100%) of the balance of the Allowance for Loan and Lease...

  9. Integrated Medium for Planetary Exploration (IMPEx): a new EU FP7-SPACE project

    Science.gov (United States)

    Khodachenko, M. L.; Genot, V. N.; Kallio, E. J.; Alexeev, I. I.; Modolo, R.; Al-Ubaidi, T.; André, N.; Gangloff, M.; Schmidt, W.; Belenkaya, E. S.; Topf, F.; Stoeckler, R.

    2011-12-01

    The FP7-SPACE project Integrated Medium for Planetary Exploration (IMPEx) has started in June 2011. It will create an interactive framework for exploitation of space missions' data. Data analysis and visualization will be based on the advanced computational models of the planetary environments. Specifically, the 'modeling sector' of IMPEx is formed of four well established numerical codes and their related computational infrastructures: 1) 3D hybrid modeling platform HYB for the study of planetary plasma environments, hosted at FMI; 2) an alternative 3D hybrid modeling platform, hosted at LATMOS; 3) MHD modelling platform GUMICS for 3D terrestrial magnetosphere, hosted at FMI; and 4) the global 3D Paraboloid Magnetospheric Model for simulation of magnetospheres of different Solar System objects, hosted at SINP. Modelling results will be linked to the corresponding experimental data from space and planetary missions via several online tools: 1/ AMDA (Automated Multi-Dataset Analysis, http://cdpp-amda.cesr.fr/) which provides cross-linked visualization and operation of experimental and numerical modelling data, 2/ 3DView which will propose 3D visualization of spacecraft trajectories in simulated and observed environments, and 3/ "CLWeb" software which enables computation of various micro-scale physical products (spectra, distribution functions, etc.). In practice, IMPEx is going to provide an external user with an access to an extended set of space and planetary missions' data and powerful, world leading computing models, equipped with advanced visualization tools. Via its infrastructure, IMPEx will bring the data and models outside of the mission teams and specialized modelling groups making them accessible and useful for a broad planetary science community.

  10. Low power reconfigurable FP-FFT core with an array of folded DA butterflies

    Science.gov (United States)

    Beulet Paul, Augusta Sophy; Raju, Srinivasan; Janakiraman, Raja

    2014-12-01

    A variable length (32 ~ 2,048), low power, floating point fast Fourier transform (FP-FFT) processor is designed and implemented using energy-efficient butterfly elements. The butterfly elements are implemented using distributed arithmetic (DA) algorithm that eliminates the power-consuming complex multipliers. The FFT computations are scheduled in a quasi-parallel mode with an array of 16 butterflies. The nodes of the data flow graph (DFG) of the FFT are folded to these 16 butterflies for any value of N by the control unit. Register minimization is also applied after folding to decrease the number of scratch pad registers to (log 2 N - 1) × 16. The real and imaginary parts of the samples are represented by 32-bit single-precision floating point notation to achieve high precision in the results. Thus, each sample is represented using 64 bits. Twiddle factor ROM size is reduced by 25% using the symmetry of the twiddle factors. Reconfigurability based on the sample size is achieved by the control unit. This distributed floating point arithmetic (DFPA)-based design of FFT processor implemented in 45-nm process occupies an area of 0.973 mm2 and dissipates a power of 68 mW at an operating frequency of 100 MHz. When compared with FFT processor designed in the same technology with multiplier-based butterflies, this design shows 33% less area and 38% less power. The throughput for 2,048-point FFT is 222 KS/s and the energy spent per FFT is 7.4 to 14 nJ for 64 to 2,048 points being one among the most energy-efficient FFT processors.

  11. Evolution of clinical features in possible DLB depending on FP-CIT SPECT result

    Science.gov (United States)

    Moreno, Emilio; Thomas, Alan; Inglis, Fraser; Tabet, Naji; Stevens, Tim; Whitfield, Tim; Aarsland, Dag; Rainer, Michael; Padovani, Alessandro

    2016-01-01

    Objective: To test the hypothesis that core and suggestive features in possible dementia with Lewy bodies (DLB) would vary in their ability to predict an abnormal dopamine transporter scan and therefore a follow-up diagnosis of probable DLB. A further objective was to assess the evolution of core and suggestive features in patients with possible DLB over time depending on the 123I-FP-CIT SPECT scan result. Methods: A total of 187 patients with possible DLB (dementia plus one core or one suggestive feature) were randomized to have dopamine transporter imaging or to follow-up without scan. DLB features were compared at baseline and at 6-month follow-up according to imaging results and follow-up diagnosis. Results: For the whole cohort, the baseline frequency of parkinsonism was 30%, fluctuations 29%, visual hallucinations 24%, and REM sleep behavior disorder 17%. Clinician-rated presence of parkinsonism at baseline was significantly (p = 0.001) more frequent and Unified Parkinson’s Disease Rating Scale (UPDRS) score at baseline was significantly higher (p = 0.02) in patients with abnormal imaging. There was a significant increase in UPDRS score in the abnormal scan group over time (p < 0.01). There was relatively little evolution of the rest of the DLB features regardless of the imaging result. Conclusions: In patients with possible DLB, apart from UPDRS score, there was no difference in the evolution of DLB clinical features over 6 months between cases with normal and abnormal imaging. Only parkinsonism and dopamine transporter imaging helped to differentiate DLB from non-DLB dementia. PMID:27511183

  12. Analysis of FP aerosol behavior in piping in WIND project. Contract research

    Energy Technology Data Exchange (ETDEWEB)

    Hidaka, Akihide; Maruyama, Yu; Shibazaki, Hiroaki; Maeda, Akio; Harada, Yuhei [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Nagashima, Toshio; Yoshino, Takehito; Sugimoto, Jun

    1998-07-01

    In the analyses of aerosol behavior test in piping in WIND (Wide Range Piping Integrity Demonstration) project at Japan Atomic Energy Research Institute (JAERI), ART code developed by JAERI and VICTORIA code developed by Sandia National Laboratories are used to perform WIND test analysis and to validate the models in the both codes. It is noted that VICTORIA code is supposed to be used as reference code of ART at JAERI. As a part of these activities, WIND Aerosol Deposition tests (WAD4 and 5) and FP aerosol behaviors in safety relief valve (SRV) line during BWR high pressure sequence which will be performed in future WIND experiment were analyzed with ART and VICTORIA codes. The present analyses showed that the portion and mass with relatively large amount of cesium iodide (CsI) deposition observed in WAD4 and 5 tests were reasonably reproduced by ART and VICTORIA codes. A difference was found in condensation and revaporization behaviors of gaseous CsI between the two codes. VICTORIA overestimated the condensed mass of CsI vapor while ART reproduced better the experimental data than the VICTORIA calculation. Further investigation is needed for this issue. Although the deposition mass at the pipe connection part in WAD4 and 5 experiments was not measured, the mass at that portion will be measured from next experiment because relatively large amount of CsI could be deposited there and the measurement is considered to be useful for code verification. The predicted principal aerosol deposition mechanism in SRV line is turbulence. Temperature of SRV line could increase by about 300 K by decay heat from deposited FPs. However, the SRV line made of carbon steel would not be failed because the predicted temperature is still far lower than the melting temperature of carbon steel. (author)

  13. Is It Worth It? - the Economics of Reusable Space Transportation

    Science.gov (United States)

    Webb, Richard

    2016-01-01

    Over the past several decades billions of dollars have been invested by governments and private companies in the pursuit of lower cost access to space through earth-to-orbit (ETO) space transportation systems. Much of that investment has been focused on the development and operation of various forms of reusable transportation systems. From the Space Shuttle to current efforts by private commercial companies, the overarching belief of those making such investments has been that reusing system elements will be cheaper than utilizing expendable systems that involve throwing away costly engines, avionics, and other hardware with each flight. However, the view that reusable systems are ultimately a "better" approach to providing ETO transportation is not held universally by major stakeholders within the space transportation industry. While the technical feasibility of at least some degree of reusability has been demonstrated, there continues to be a sometimes lively debate over the merits and drawbacks of reusable versus expendable systems from an economic perspective. In summary, is it worth it? Based on our many years of direct involvement with the business aspects of several expendable and reusable transportation systems, it appears to us that much of the discussion surrounding reusability is hindered by a failure to clearly define and understand the financial and other metrics by which the financial "goodness" of a reusable or expandable approach is measured. As stakeholders, the different users and suppliers of space transportation have a varied set of criteria for determining the relative economic viability of alternative strategies, including reusability. Many different metrics have been used to measure the affordability of space transportation, such as dollars per payload pound (kilogram) to orbit, cost per flight, life cycle cost, net present value/internal rate of return, and many others. This paper will examine the key considerations that influence

  14. Fast Neutron Spectrum Potassium Worth for Space Power Reactor Design Validation

    Energy Technology Data Exchange (ETDEWEB)

    Bess, John D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Marshall, Margaret A. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Briggs, J. Blair [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tsiboulia, Anatoli [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rozhikhin, Yevgeniy [Idaho National Lab. (INL), Idaho Falls, ID (United States); Mihalczo, John T. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    graphite reflected (2 inches or less) experiments also using the same set of highly enriched uranium metal parts are evaluated in HEU MET FAST 071. Polyethylene-reflected configurations are evaluated in HEU-MET-FAST-076. A stack of highly enriched metal discs with a thick beryllium top reflector is evaluated in HEU-MET-FAST-069, and two additional highly enriched uranium annuli with beryllium cores are evaluated in HEU-MET-FAST-059. Both detailed and simplified model specifications are provided in this evaluation. Both of these fast neutron spectra assemblies were determined to be acceptable benchmark experiments. The calculated eigenvalues for both the detailed and the simple benchmark models are within ~0.26 % of the benchmark values for Configuration 1 (calculations performed using MCNP6 with ENDF/B-VII.1 neutron cross section data), but under-calculate the benchmark values by ~7s because the uncertainty in the benchmark is very small: ~0.0004 (1s); for Configuration 2, the under-calculation is ~0.31 % and ~8s. Comparison of detailed and simple model calculations for the potassium worth measurement and potassium mass coefficient yield results approximately 70 – 80 % lower (~6s to 10s) than the benchmark values for the various nuclear data libraries utilized. Both the potassium worth and mass coefficient are also deemed to be acceptable benchmark experiment measurements.

  15. Long-term orbital period behaviour of low mass ratio contact binaries GR Vir and FP Boo

    Science.gov (United States)

    Ćetinkaya, Halil; Soydugan, Faruk

    2017-02-01

    In this study, we investigated orbital period variations of two low mass ratio contact binaries GR Vir and FP Boo based on published minima times. From the O-C analysis, it was found that FP Boo indicates orbital period decrease while the period of GR Vir is increasing. Mass transfer process was used to explain increase and decrease in the orbital periods. In the O-C diagrams of both systems periodic variations also exist. Cyclic changes can be explained as being the result of a light-travel time effect via a third component around the eclipsing binaries. In order to interpret of cyclic orbital period changes for GR Vir, which has late-type components, possible magnetic activity cycles of the components have been also considered.

  16. Sensitivity analysis for CORSOR models simulating fission product release in LOFT-LP-FP-2 severe accident experiment

    Energy Technology Data Exchange (ETDEWEB)

    Hoseyni, Seyed Mohsen [Islamic Azad Univ., Tehran (Iran, Islamic Republic of). Dept. of Basic Sciences; Islamic Azad Univ., Tehran (Iran, Islamic Republic of). Young Researchers and Elite Club; Pourgol-Mohammad, Mohammad [Sahand Univ. of Technology, Tabriz (Iran, Islamic Republic of). Dept. of Mechanical Engineering; Yousefpour, Faramarz [Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of)

    2017-03-15

    This paper deals with simulation, sensitivity and uncertainty analysis of LP-FP-2 experiment of LOFT test facility. The test facility simulates the major components and system response of a pressurized water reactor during a LOCA. MELCOR code is used for predicting the fission product release from the core fuel elements in LOFT LP-FP-2 experiment. Moreover, sensitivity and uncertainty analysis is performed for different CORSOR models simulating release of fission products in severe accident calculations for nuclear power plants. The calculated values for the fission product release are compared under different modeling options to the experimental data available from the experiment. In conclusion, the performance of 8 CORSOR modeling options is assessed for available modeling alternatives in the code structure.

  17. X-ray diffraction analysis and molecular-replacement solution of the cyan fluorescent protein dsFP483

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Meitian; Patel, Hetal N.; Wachter, Rebekka M., E-mail: rwachter@asu.edu [Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona (United States)

    2005-10-01

    The coral-derived cyan fluorescent protein dsFP483 has been crystallized and diffraction data were collected to 2.1 Å. A molecular-replacement solution is presented for 83% of the protein contents of the asymmetric unit. A novel cyan fluorescent protein, dsFP483 from the coral Discosoma striata, has been crystallized. Diffraction data were collected to 2.1 Å and processed in space group C2. Molecular-replacement methods were applied using the closely related red fluorescent protein DsRed as a search model. The asymmetric unit appears to contain six protein molecules (1.5 tetramers), five of which (83%) could be located by the molecular-replacement searches.

  18. Employing injection-locked FP LDs to set up a hybrid CATV/MW/MMW WDM light wave transmission system.

    Science.gov (United States)

    Lin, Chun-Yu; Lu, Hai-Han; Li, Chung-Yi; Wu, Po-Yi; Peng, Peng-Chun; Jhang, Tai-Wei; Lin, Che-Yu

    2014-07-01

    A hybrid cable television (CATV)/microwave (MW)/millimeter-wave (MMW) wavelength-division-multiplexing (WDM) light wave transmission system based on injection-locked Fabry-Perot laser diodes (FP LDs) is proposed and demonstrated. Different from conventional hybrid WDM light wave transmission systems, which need wavelength-selected distributed feedback laser diodes to support various services, the proposed systems employ injection-locked FP LDs to provide multiple applications. Over a 40 km single-mode fiber transport, impressive performances of carrier-to-noise ratio/composite second-order/composite triple-beat/bit error rate are obtained for 550 MHz CATV/20 GHz MW/40 GHz MMW/60 GHz MMW signal transmissions. Such a hybrid WDM light wave transmission system would be attractive for fiber links to provide broadband integrated services.

  19. Scientific Opinion on the Pest Risk Analysis on Phytophthora ramorum prepared by the FP6 project RAPRA

    DEFF Research Database (Denmark)

    Baker, R.; Candresse, T.; Dormannsné Simon, E.

    2011-01-01

    The Panel on Plant Health was asked to deliver a scientific opinion on the Pest Risk Analysis on Phytophthora ramorum prepared by the FP6 project RAPRA, taking into account comments by Member States and additional information since RAPRA. P. ramorum is the oomycete causing sudden oak death...... research on P. ramorum across Europe. Regulatory work should keep updated with research results on P. ramorum and further development of the Japanese larch outbreaks....

  20. Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine

    OpenAIRE

    Grigoryan, Hasmik; Li, Bin; Anderson, Erica K.; Xue, Weihua; Nachon, Florian; Lockridge, Oksana; Schopfer, Lawrence M.

    2009-01-01

    Organophosphorus esters (OP) are known to bind covalently to the active site serine of enzymes in the serine hydrolase family. It was a surprise to find that proteins with no active site serine are also covalently modified by OP. The binding site in albumin, transferrin, and tubulin was identified as tyrosine. The goal of the present work was to determine whether binding to tyrosine is a general phenomenon. Fourteen proteins were treated with a biotin-tagged organophosphorus agent called FP-b...

  1. Weighted composition operators from F(p, q, s) spaces to Bers-type spaces in the unit ball

    Institute of Scientific and Technical Information of China (English)

    L(U) Xiao-fen

    2009-01-01

    This paper deals with the boundedness and compactness of the weighted compo-sition operators from the F(p, q, s) spaces, including Hardy space, Bergman space, Q~p space,BMOA space, Besov space and α-Bloch space, to Bers-type spaces H_ν~∞( or little Bets-type spaces H_(ν,0)~∞ ), where ν is normal.

  2. Applications research in ultrasonic testing of carbon fiber composite based on an optical fiber F-p sensor

    Science.gov (United States)

    Shan, Ning

    2016-10-01

    Carbon fiber composite is widely applied to the field of aerospace engineering because of its excellent performance. But it will be able to form more defects in the process of manufacturing inevitably on account of unique manufacturing process. Meanwhile it has sophisticated structure and services in the bad environment long time. The existence of defects will be able to cause the sharp decline in component's performance when the defect accumulates to a certain degree. So the reliability and safety test demand of carbon fiber composite is higher and higher. Ultrasonic testing technology is the important means used for characteristics of component inspection of composite materials. Ultrasonic information detection uses acoustic transducer generally. It need coupling agent and is higher demand for the surface of sample. It has narrow frequency band and low test precision. The extrinsic type optical fiber F-P interference cavity structure is designed to this problem. Its optical interference model is studied. The initial length of F-P cavity is designed. The realtime online detection system of carbon fiber composite is established based on optical fiber F-P Ultrasound sensing technology. Finally, the testing experiment study is conducted. The results show that the system can realize real-time online detection of carbon fiber composite's defect effectively. It operates simply and realizes easily. It has low cost and is easy to practical engineering.

  3. Comparison of FP-CIT SPECT with F-DOPA PET in patients with de novo and advanced Parkinson's disease

    Energy Technology Data Exchange (ETDEWEB)

    Eshuis, S.A. [University Hospital Groningen, Department of Neurology, Groningen (Netherlands); University Hospital Groningen, Department of Nuclear Medicine, Groningen (Netherlands); Maguire, R.P.; Leenders, K.L. [University Hospital Groningen, Department of Neurology, Groningen (Netherlands); Jonkman, S.; Jager, P.L. [University Hospital Groningen, Department of Nuclear Medicine, Groningen (Netherlands)

    2006-02-01

    Diagnosis of Parkinson's disease (PD) can be difficult. F-DOPA PET is able to quantify striatal dopa decarboxylase activity and storage capacity of F-dopamine, but is expensive and not generally available. FP-CIT binds to the dopamine transporter, and FP-CIT SPECT is cheaper and more widely available, but has a lower resolution. The aim of this study was to compare these two methods in the same patients with different stages of PD to assess their power in demonstrating deficits of the striatal dopaminergic system. Thirteen patients with de novo PD and 17 patients with advanced PD underwent FP-CIT SPECT and static F-DOPA PET. After data transfer to standard stereotactic space, a template with regions of interest was used to sample values of the caudate, putamen and an occipital reference region. The outcome value was striato-occipital ratios. Patients were clinically examined in the ''off state'' (UPDRS-III and H and Y stage). Good correlations were found between striatal F-DOPA uptake and striatal FP-CIT uptake (r=0.78) and between putaminal F-DOPA uptake and putaminal FP-CIT uptake (r=0.84, both p<0.0001). Both striatal uptake of FP-CIT and that of F-DOPA correlated moderately with H and Y stage ({rho}=-0.52 for both techniques), UPDRS-III ({rho}=-0.38 for F-DOPA; {rho}=-0.45 for FP-CIT) and disease duration ({rho}=-0.59 for F-DOPA; {rho}=-0.49 for FP-CIT, all p<0.05). FP-CIT values correlate well with F-DOPA values. Both methods correlate moderately with motor scores and are equally able to distinguish patients with advanced PD from patients with de novo PD. (orig.)

  4. [O-methyl-{sup 11}C]{beta}-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: Preparation, autoradiography, metabolite studies, and positron emission tomography examinations

    Energy Technology Data Exchange (ETDEWEB)

    Lundkvist, Camilla; Halldin, Christer; Swahn, Carl-Gunnar; Hall, Haakan; Karlsson, Per; Nakashima, Yoshifumi; Wang, Shaoyin; Milius, Richard A.; Neumeyer, John L.; Farde, Lars

    1995-10-01

    {beta}-CIT-FP [N-(3-fluoropropyl)-2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)nortropane] is a cocaine analogue with a high affinity for the dopamine transporter. [O-methyl-{sup 11}C]{beta}-CIT-FP ([{sup 11}C]{beta}-CIT-FP) was prepared byO -alkylation of the free acid with [{sup 11}C]methyl iodide. The total radiochemical yield of [{sup 11}C]{beta}-CIT-FP was 50 to 60% with an overall synthesis time of 30 min. The radiochemical purity was >99%, and the specific radioactivity at time of injection was about 37 GBq/{mu}mol (1000 Ci/mmol). Autoradiographic examination of [{sup 11}C]{beta}-CIT-FP binding in human brain postmortem demonstrated specific binding in the caudate nucleus and putamen. Positron emission tomography (PET) examination of [{sup 11}C]{beta}-CIT-FP in a Cynomolgus monkey demonstrated accumulation in the striatum with a striatum-to-cerebellum ratio of about 8 after 60 min. Equilibrium in the striatum was attained within 70 to 90 min. The radioactivity ratios of thalamus/cerebellum and neocortex/cerebellum were about 2 and 1.5, respectively. In a displacement experiment, radioactivity in the striatum but not in the cerebellum was reduced after injection of {beta}-CIT, indicating that striatal radioactivity following injection of [{sup 11}C]{beta}-CIT-FP is associated with dopamine transporter sites and that the binding is reversible. The fraction of the total radioactivity in plasma representing [{sup 11}C]{beta}-CIT-FP determined by high-performance liquid chromatography (HPLC) was 84% at 15 min and 50% at 95 min. [{sup 11}C]{beta}-CIT-FP should be a useful PET radioligand for the quantitation of dopamine transporters in the human brain in vivo.

  5. Human biodistribution and dosimetry of [{sup 123}I]FP-CIT: a potent radioligand for imaging of dopamine transporters

    Energy Technology Data Exchange (ETDEWEB)

    Booij, J.; Busemann Sokole, E.; De Bruin, K.; Van Royen, E.A. [Graduate School of Neurosciences, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands); Stabin, M.G. [Radiation Internal Dose Information Center, Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee (United States); Janssen, A.G.M. [Amersham Cygne and Eindhoven University of Technology, Eindhoven (Netherlands)

    1998-01-01

    This study reports on the biodistribution and radiation dosimetry of iodine-123-labelled N-{omega}-(flu- oropropyl)-2{beta}-carbomethoxy-3{beta}-(4-iodophenyl)tropane ([{sup 123}I]FP-CIT), a promising radioligand for the imaging of dopamine transporters. In 12 healthy volunteers, conjugate whole-body scans were performed up to 48 h following intravenous injection of approximately 100 MBq [{sup 123}I]FP-CIT. Attenuation correction was performed using a transmission whole-body scan obtained prior to injection of the radioligand, employing a {sup 123}I flood source. Blood samples were taken and urine was freely collected up to 48 h after injection of the radiotracer. For each subject, the percentage of injected activity measured in regions of interest over brain, striatum, lungs and liver were fitted to a multicompartmental model to give time-activity curves. The cumulative urine activity curve was used to model the urinary excretion rate and, indirectly, to predict faecal excretion. Using the MIRD method, nine source organs were considered in estimating absorbed radiation doses for organs of the body. The images showed rapid lung uptake and hepatobiliary excretion. Diffuse uptake and retention of activity was seen in the brain, especially in the striatum. At 48 h following the injection of [{sup 123}I]FP-CIT, mean measured urine excretion was 60%{+-}9% (SD), and mean predicted excretion in faeces was 14%{+-}1%. In general, the striatum received the highest absorbed dose (average 0.23 mGy/MBq), followed by the urinary bladder wall (average 0.054 mGy/MBq) and lungs (average 0.043 mGy/MBq). The average effective dose equivalent of [{sup 123}I]FP-CIT was estimated to be 0.024 mSv/MBq. The amount of [{sup 123}I]FP-CIT required for adequate dopamine transporter imaging results in an acceptable effective dose equivalent to the patient. (orig.) With 3 figs., 4 tabs., 39 refs.

  6. An FP7 "Space" project: Aphorism "Advanced PRocedures for volcanic and Seismic Monitoring"

    Science.gov (United States)

    Di Iorio, A., Sr.; Stramondo, S.; Bignami, C.; Corradini, S.; Merucci, L.

    2014-12-01

    APHORISM project proposes the development and testing of two new methods to combine Earth Observation satellite data from different sensors, and ground data. The aim is to demonstrate that this two types of data, appropriately managed and integrated, can provide new improved GMES products useful for seismic and volcanic crisis management. The first method, APE - A Priori information for Earthquake damage mapping, concerns the generation of maps to address the detection and estimate of damage caused by a seism. The use of satellite data to investigate earthquake damages is not an innovative issue. We can find a wide literature and projects concerning such issue, but usually the approach is only based on change detection techniques and classifications algorithms. The novelty of APE relies on the exploitation of a priori information derived by InSAR time series to measure surface movements, shake maps obtained from seismological data, and vulnerability information. This a priori information is then integrated with change detection map to improve accuracy and to limit false alarms. The second method deals with volcanic crisis management. The method, MACE - Multi-platform volcanic Ash Cloud Estimation, concerns the exploitation of GEO (Geosynchronous Earth Orbit) sensor platform, LEO (Low Earth Orbit) satellite sensors and ground measures to improve the ash detection and retrieval and to characterize the volcanic ash clouds. The basic idea of MACE consists of an improvement of volcanic ash retrievals at the space-time scale by using both the LEO and GEO estimations and in-situ data. Indeed the standard ash thermal infrared retrieval is integrated with data coming from a wider spectral range from visible to microwave. The ash detection is also extended in case of cloudy atmosphere or steam plumes. APE and MACE methods have been defined in order to provide products oriented toward the next ESA Sentinels satellite missions.The project is funded under the European Union FP7

  7. Femtosecond study of light-induced fluorescence increase of the dark chromoprotein asFP595

    Energy Technology Data Exchange (ETDEWEB)

    Schuettrigkeit, Tanja A. [Department Chemie, Technische Universitaet Muenchen, 85747 Garching (Germany); Feilitzsch, Till von [Department Chemie, Technische Universitaet Muenchen, 85747 Garching (Germany); Kompa, Christian K. [Department Chemie, Technische Universitaet Muenchen, 85747 Garching (Germany); Lukyanov, Konstantin A. [Shemiakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow (Russian Federation); Savitsky, Alexander P. [A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow (Russian Federation); Voityuk, Alexander A. [Institucio Catalana de Recerca i Estudis Avancats (ICREA), Institute of Computational Chemistry, Universitat de Girona (Spain); Michel-Beyerle, Maria E. [Department Chemie, Technische Universitaet Muenchen, 85747 Garching (Germany)], E-mail: michel-beyerle@ch.tum.de

    2006-04-21

    Femtosecond time-resolved spectroscopy is applied to study the mechanism of the light-induced increase of fluorescence quantum yield of the initially non-fluorescent (dark) chromoprotein asFP595. Spectroscopic and kinetic characteristics of this unique fluorescence 'kindling' phenomenon are: (i) the small Stokes shift of the dark chromophore consistent with either the zwitterion or the anion; (ii) the singlet excited state of the dark chromophore decaying predominantly with a time constant of {approx}320 fs corresponding to a fluorescence quantum yield {phi} {sub Fl} {<=} 10{sup -4}. Since ground state recovery occurs on the same time scale, this radiationless channel is assigned to internal conversion; (iii) the formation of the fluorescent species depending on the sequential absorption of two photons with a delay significantly exceeding the excitation pulse duration of 150 fs; (iv) the fluorescent species showing a red-shift of {approx}20 nm in absorption and emission, and an excited state lifetime of 2.2 ns. The ultrafast internal conversion of the excited dark state is attributed to the proximity of the S{sub 0} and S{sub 1} potential energy surfaces favored by the non-planarity of the chromophore as revealed in recent X-ray structures. Competing with internal conversion two different transformations of the chromophore structure are suggested which may be identified in a future X-ray structural analysis of the the photoconverted fluorescent state. The predominant kindling mechanism may be either (i) trans-cis isomerization or (ii) proton transfer between an excited zwitterion and the protein cleft. For mechanism (ii) the large dipole moment change of about 11 D upon S{sub 0}-S{sub 1} excitation of the chromophore would be crucial in order to initiate protein relaxation and deprotonation of a zwitterion. Both mechanisms are assumed to lead to a metastable planar structure responsible for the long-lived fluorescence of the chromophore &apos

  8. Evaluating Liberal Learning: Doubts and Explorations.

    Science.gov (United States)

    Green, Thomas F.

    1982-01-01

    In current evaluation practice, the implicit philosophy of value, appraisal, and action is seen as a form of Benthamite utilitarianism. A domain of value called "educational worth" is described. Ways of detecting the presence of educational worth in liberal learning programs are identified. (MLW)

  9. Evaluating Liberal Learning: Doubts and Explorations.

    Science.gov (United States)

    Green, Thomas F.

    1982-01-01

    In current evaluation practice, the implicit philosophy of value, appraisal, and action is seen as a form of Benthamite utilitarianism. A domain of value called "educational worth" is described. Ways of detecting the presence of educational worth in liberal learning programs are identified. (MLW)

  10. No Occasion for Pleasure: The Self-Worth Contingency of a Setback and Coping With Humor

    Directory of Open Access Journals (Sweden)

    Fay Caroline Mary Geisler

    2014-08-01

    Full Text Available Whether or not one uses humor to cope with a setback may depend on the idiosyncratic relation of the setback to feeling of self-worth. All people pursue the higher order goal of self-validation, but people differ in what domains of life their self-worth is contingent upon and to what extent. In this article based on an incongruity theory of humor we argue that the use of humor in coping with a highly self-worth-contingent setback may be impeded by two cognitive-motivational processes: goal-driven activation and goal shielding. From the outlined theory we derived the hypothesis that the more a domain is contingent upon self-worth, the less likely a person will be to use humor to deal with a setback in that domain. We tested this hypothesis in two studies employing two forms of self-report, i.e., ratings of reaction likelihood to setbacks described at an abstract domain level (Study 1, and ranking of reaction likelihood to concrete setbacks from different domains (Study 2. The hypothesis was affirmed in different domains of self-worth contingency controlling for the influence of habitual coping with humor, coping by disengagement, and global self-esteem.

  11. Construction of expression vector and transformation of FpDREB2A gene into Robinia pseudoacacia 'Idaho' mediated with Agrobacterium tumefaciens

    Institute of Scientific and Technical Information of China (English)

    Zeng Hui-ming; Wang Hua-fang

    2006-01-01

    The transcription factor gene FpDREB2A of Fraxinus pennsylvanica Marsh var. subintegerrima (Vahl.) Fern was conmefaciens GV3101. Callus was screened with G418. Morphogenesis of shoots and roots of Idaho locust transformed genes was carried out on antibiotic media. The transformed plants were verified by PCR and Southern blotting tests that the FpDREB2A gene had been inserted into the genome DNA of Idaho locust.

  12. Perfectionism and Contingent Self-Worth in Relation to Disordered Eating and Anxiety.

    Science.gov (United States)

    Bardone-Cone, Anna M; Lin, Stacy L; Butler, Rachel M

    2017-05-01

    Perfectionism has been proposed as a transdiagnostic risk factor linked to eating disorders and anxiety. In the current study, we examine domains of contingent self-worth as potential moderators of the relationships between maladaptive perfectionism and disordered eating and anxiety using two waves of data collection. Undergraduate females (N = 237) completed online surveys of the study's core constructs at two points separated by about 14 months. At a bivariate level, maladaptive perfectionism was positively associated with disordered eating and anxiety. Maladaptive perfectionism and both appearance and relationship contingent self-worth interacted to predict increases in disordered eating. Neither of the interactive models predicted change in anxiety. Findings highlight maladaptive perfectionism as a transdiagnostic construct related to both disordered eating and anxiety. Interactive findings suggest that targeting maladaptive perfectionism and contingent self-worth (appearance, relationship) in prevention and treatment efforts could mitigate risk for the development or increase of disordered eating. Copyright © 2016. Published by Elsevier Ltd.

  13. Contingencies of self-worth and social-networking-site behavior.

    Science.gov (United States)

    Stefanone, Michael A; Lackaff, Derek; Rosen, Devan

    2011-01-01

    Social-networking sites like Facebook enable people to share a range of personal information with expansive groups of "friends." With the growing popularity of media sharing online, many questions remain regarding antecedent conditions for this behavior. Contingencies of self-worth afford a more nuanced approach to variable traits that affect self-esteem, and may help explain online behavior. A total of 311 participants completed an online survey measuring such contingencies and typical behaviors on Facebook. First, exploratory factor analyses revealed an underlying structure to the seven dimensions of self-worth. Public-based contingencies explained online photo sharing (β = 0.158, p self-worth had the strongest relationship with the intensity of online photo sharing (β = 0.242), although no relationship was evident for time spent managing profiles.

  14. Estimation of Control Rod Worth in a VVER-1000 Reactor using DRAGON4 and DONJON4

    Directory of Open Access Journals (Sweden)

    Saadatian-derakhshandeh Farahnaz

    2014-07-01

    Full Text Available One of the main issues in safety and control systems design of power and research reactors is to prevent accidents or reduce the imposed hazard. Control rod worth plays an important role in safety and control of reactors. In this paper, we developed a justifiable approach called D4D4 to estimate the control rod worth of a VVER-1000 reactor that enables to perform the best estimate analysis and reduce the conservatism that utilize DRAGON4 and DONJON4. The results are compared with WIMS-D4/CITATION to show the effectiveness and superiority of the developed package in predicting reactivity worth of the rod and also other reactor physics parameters of the VVER-1000 reactor. The results of this study are in good agreement with the plant's FSAR.

  15. Physical Activity and Global Self-worth in a Longitudinal Study of Children.

    Science.gov (United States)

    Reddon, Hudson; Meyre, David; Cairney, John

    2017-08-01

    Physical activity is associated with an array of physical and mental health benefits among children and adolescents. The development of self-worth/self-esteem has been proposed as a mechanism to explain the mental health benefits derived from physical activity. Despite several studies that have analyzed the association between physical activity and self-worth, the results have been inconsistent. It is also uncertain how related physical health measures, such as sedentary behavior, body composition, and fitness, influence the relationship between physical activity and self-worth over time. In the present study, we 1) analyzed if the association between physical activity and self-worth remained constant over time and whether this relationship varied by sex and 2) investigated if changes in body composition and fitness level mediated the relationship between physical activity and self-worth. Data from the Physical Health Activity Study Team were used for this analysis. The Physical Health Activity Study Team is a prospective cohort study that included 2278 children at baseline (ages 9-10 yr) and included eight follow-up contacts for a 4-yr study period. Linear mixed-effects models were used to estimate global self-worth (GSW) over follow-up. Increased physical activity was associated with greater GSW across all waves of data collection, and this relationship did not vary significantly over time or between sexes. Aerobic fitness was positively associated with GSW, whereas body mass index (BMI) was inversely related to GSW. Both aerobic fitness and BMI appeared to mediate the association between physical activity and GSW. Sedentary behavior was not significantly associated with GSW. Physical activity is associated with greater GSW, and this relationship appears to be mediated by BMI and aerobic fitness. These findings reinforce the importance of physical behaviors and physical characteristics in shaping GSW in children.

  16. A Sense of Worth: Seven Days with Hamlet.

    Science.gov (United States)

    Harrison, Bernard T.

    1984-01-01

    Discusses the effectiveness of a week-long teacher inservice workshop on Shakespeare's "Hamlet" in the context of an analysis of participants' responses to a 10-question evaluation of the inservice. (AEA)

  17. A Sense of Worth: Seven Days with Hamlet.

    Science.gov (United States)

    Harrison, Bernard T.

    1984-01-01

    Discusses the effectiveness of a week-long teacher inservice workshop on Shakespeare's "Hamlet" in the context of an analysis of participants' responses to a 10-question evaluation of the inservice. (AEA)

  18. Non-polio enteroviruses associated with acute flaccid paralysis (AFP) and facial paralysis (FP) cases in Romania, 2001-2008.

    Science.gov (United States)

    Persu, Ana; Băicuş, Anda; Stavri, Simona; Combiescu, Mariana

    2009-01-01

    Acute flaccid paralysis is a complex clinical syndrome, with a wide variety of possible etiologies and with clinical manifestations that can vary according to age or geographical region. Enteroviruses (polioviruses and non-polio enteroviruses) are among the viral agents that can cause AFP. AFP surveillance is important for public health through its use in monitoring poliomyelitis, in the context of the Global Initiative to eradicate this disease. The current paper aims to assess the non-polio enteroviruses (NPEV) association with AFP and FP cases registered in Romania in the period 2001-2008 and to identify prevalent serotypes. Within the framework of Surveillance of AFP Cases Program, were collected samples from 579 children with AFP or FP (3.069 samples). The samples were processed and inoculated onto two types of cell culture (RD and L20B), according to WHO protocol. The identification of isolated viruses has been done by the reaction of seroneutralization with pools of specific antiserum and then with monospecific antiserum for confirmation. NPEV were isolated from 58 cases (123 positive samples). During the analyzed period, 23 NPEV serotypes have circulated (15 Echo serotypes and 8 coxsackie serotypes). The most frequently identified were the Echoviruses 13 and 11 and the coxsackie A viruses. 88% of positive cases have occurred in children between 1 and 5 years. As seasonal distribution, the peak of NPEV circulation was in the months August-September (36.2%). The paper provides information about NPEV circulation in Romania in the past 8 years, about its association with the AFP and FP and it indicates the need for monitoring NPEV circulation even after the eradication of poliomyelitis.

  19. Influence of CT-based attenuation correction on dopamine transporter SPECT with [(123)I]FP-CIT.

    Science.gov (United States)

    Lapa, Constantin; Spehl, Timo S; Brumberg, Joachim; Isaias, Ioannis U; Schlögl, Susanne; Lassmann, Michael; Herrmann, Ken; Meyer, Philipp T

    2015-01-01

    Dopamine transporter (DAT) imaging using single-photon emission computed tomography (SPECT) and (123)I-labelled radiopharmaceuticals like [(123)I]FP-CIT is an established part in the diagnostic work-up of parkinsonism. Guidelines recommend attenuation correction (AC), either by a calculated uniform attenuation matrix (calAC) or by a measured attenuation map (nowadays done by low-dose CT; CTAC). We explored the impact of CTAC compared to conventional calAC on diagnostic accuracy and the use of DAT availability as a biomarker of nigrostriatal integrity.Integrated SPECT/CT studies with [(123)I]FP-CIT were performed in patients with Parkinson's disease (PD; n = 15) and essential tremor (ET; n = 15). SPECT data was reconstructed with calAC, CTAC and without AC (noAC). Regional DAT availability was assessed by uniform volume-of-interest analyses providing striatal binding potential (BP ND) estimates. BP ND values were compared among methods and correlated with clinical parameters. Compared to calAC, both CTAC and noAC provided significantly lower, but highly linearly correlated BP ND estimates (R (2) = 0.96). Diagnostic performance to distinguish between patients with PD and those with ET was very high and did not differ between AC methods. CTAC and noAC data tended so show a stronger correlation with severity and duration of disease in PD and age in ET than did calAC. Defining the reference region on low-dose CT instead of SPECT did not consistently alter findings. [(123)I]FP-CIT SPECT provides a very high diagnostic accuracy for differentiation between PD and ET that is not dependent on the employed AC method. Preliminary correlations analyses suggest that BP ND estimates derived from CTAC represent a superior biomarker of nigrostriatal integrity.

  20. {sup 123}I-FP-CIT SPECT findings and its clinical relevance in prodromal dementia with Lewy bodies

    Energy Technology Data Exchange (ETDEWEB)

    Kasanuki, Koji [Juntendo University School of Medicine, PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo (Japan); Juntendo University School of Medicine, Department of Psychiatry, Tokyo (Japan); Mayo Clinic, Department of Neuroscience, Jacksonville, FL (United States); Iseki, Eizo; Ota, Kazumi [Juntendo University School of Medicine, PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo (Japan); Juntendo University School of Medicine, Department of Psychiatry, Tokyo (Japan); Kondo, Daizo; Sato, Kiyoshi [Juntendo University School of Medicine, PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo (Japan); Ichimiya, Yosuke; Arai, Heii [Juntendo University School of Medicine, Department of Psychiatry, Tokyo (Japan)

    2017-03-15

    Evidence for the prodromal stage of dementia with Lewy bodies (DLB) is very limited. To address this issue, we investigate the {sup 123}I-FP-CIT SPECT measure of dopamine transporter binding finding and its clinical relevance. We enrolled subjects into a prodromal DLB group (PRD-DLB) (n = 20) and clinical DLB group (CLIN-DLB) (n = 18) and compared these groups with an Alzheimer's disease control group (AD) (n = 10). PRD-DLB was defined as patients having the non-motor symptoms associated with Lewy body disease (LBD) [i.e. REM sleep behavior disorder (RBD), olfactory dysfunction, autonomic dysfunction, and depression] and showing characteristic diffuse occipital hypometabolism in {sup 18}F-FDG PET. CLIN-DLB was defined as patients fulfilling the established criteria of probable DLB. Striatal specific binding ratio (SBR) of {sup 123}I-FP-CIT SPECT was used for objective group comparisons. The correlations between SBR and cognitive function (MMSE), motor symptoms (UPDRS3), and duration of LBD-associated non-motor symptoms were compared between the two DLB groups. Mean SBR scores of both PRD-DLB and CLIN-DLB were significantly lower than those of AD. No correlation was found between SBR and MMSE scores. Both in the CLIN-DLB and total DLB groups, SBR scores were negatively correlated with UPDRS3 scores, whereas no correlation was found in PRD-DLB. Among the LBD-related non-motor symptoms, duration of olfactory dysfunction, and RBD demonstrated negative correlation with SBR scores in PRD-DLB. {sup 123}I-FP-CIT SPECT may play a role for detecting DLB among the subjects in prodromal stage. During this stage, long-term olfactory dysfunction and/or RBD may indicate more severe degeneration of the nigro-striatal dopaminergic pathway. (orig.)

  1. The Value of a Purposeful Life: Sense of Purpose Predicts Greater Income and Net Worth.

    Science.gov (United States)

    Hill, Patrick L; Turiano, Nicholas A; Mroczek, Daniel K; Burrow, Anthony L

    2016-12-01

    Having a sense of purpose in life appears valuable across life domains, though it remains unclear whether purpose also provides financial value to individuals. The current study examined sense of purpose as a predictor of concurrent and longitudinal income and net worth levels, using two waves of the MIDUS sample of adults (N = 4660 across both assessments). Participants who reported a higher sense of purpose had higher levels of household income and net worth initially, and were more likely to increase on these financial outcomes over the nine years between assessments. Interaction tests suggested some evidence of age moderation, but gender did not appear to moderate the influence of purpose on economic outcomes.

  2. Cauchy-Matern Model of Sea Surface Wind Speed at the Lake Worth, Florida

    Directory of Open Access Journals (Sweden)

    Ming Li

    2012-01-01

    Full Text Available We study the Cauchy-Matern (CM process with long-range dependence (LRD. The closed form of its power spectrum density (PSD function is given. We apply it to model the autocovariance function (ACF and the PSD of the sea surface wind speed (wind speed for short observed in the Lake Worth, Florida, over the 1984–2006 period. The present results exhibit that the wind speed at the Lake Worth over 1984–2006 is of LRD. The present results exhibit that the CM process may yet be a novel model to fit the wind speed there.

  3. Photon and decay data libraries for ORIGEN2 code based on JENDL FP decay data file 2000

    Energy Technology Data Exchange (ETDEWEB)

    Katakura, Jun-ichi; Yanagisawa, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2002-11-01

    Photon and decay data libraries for the ORIGEN2 code have been updated by using JENDL FP Decay Data File 2000 (JENDL/FPD-00). As for the decay data, half-lives, branching ratios and recoverable energy values have been replaced with those of the JENDL/FPD-00 file. The data of the photon library has been also replaced with those of the JENDL/FPD-00 file in which photon data of the nuclides without measured data are calculated with a theoretical method. Using the updated photon library, the calculation of photon spectrum at a short time after fission event is able to be made. (author)

  4. Silicon-Light: a European FP7 Project Aiming at High Efficiency Thin Film Silicon Solar Cells on Foil

    DEFF Research Database (Denmark)

    Soppe, W.; Haug, F.-J.; Couty, P.

    2011-01-01

    Silicon-Light is a European FP7 project, which started January 1st, 2010 and aims at development of low cost, high-efficiency thin film silicon solar cells on foil. Three main routes are explored to achieve these goals: a) advanced light trapping by implementing nanotexturization through UV Nano...... Imprinting Lithography (UV-NIL); b) growth of crack-free silicon absorber layers on highly textured substrates; c) development of new TCOs which should combine the best properties of presently available materials like ITO and AZO. The paper presents the midterm status of the project results, showing model...

  5. Influence of CT-based attenuation correction on dopamine transporter SPECT with [123I]FP-CIT

    OpenAIRE

    Lapa, Constantin; Spehl, Timo S; Brumberg, Joachim; Isaias, Ioannis U; Schlögl, Susanne; Lassmann, Michael; Herrmann, Ken; Philipp T. Meyer

    2015-01-01

    Dopamine transporter (DAT) imaging using single-photon emission computed tomography (SPECT) and 123I-labelled radiopharmaceuticals like [123I]FP-CIT is an established part in the diagnostic work-up of parkinsonism. Guidelines recommend attenuation correction (AC), either by a calculated uniform attenuation matrix (calAC) or by a measured attenuation map (nowadays done by low-dose CT; CTAC). We explored the impact of CTAC compared to conventional calAC on diagnostic accuracy and the use of DAT...

  6. Intermediate-energy inverse-kinematics one-proton pickup reactions on neutron-deficient $fp$-shell nuclei

    CERN Document Server

    McDaniel, S; Tostevin, J A; Baugher, T; Bazin, D; Brown, B A; Cook, J M; Glasmacher, T; Grinyer, G F; Ratkiewicz, A; Weisshaar, D

    2012-01-01

    Background: Thick-target-induced nucleon-adding transfer reactions onto energetic rare-isotope beams are an emerging spectroscopic tool. Their sensitivity to single-particle structure complements one-nucleon removal reaction capabilities in the quest to reveal the evolution of nuclear shell structure in very exotic nuclei. Purpose: To add intermediate-energy, carbon-target-induced one-proton pickup reactions to the arsenal of $\\gamma$-ray tagged direct reactions applicable in the regime of low beam intensities and to apply these for the first time to $fp$-shell nuclei. Methods: Inclusive and partial cross sections were measured for the $\

  7. Photon and decay data libraries for ORIGEN2 code based on JENDL FP decay data file 2000

    CERN Document Server

    Katakura, J I

    2002-01-01

    Photon and decay data libraries for the ORIGEN2 code have been updated by using JENDL FP Decay Data File 2000 (JENDL/FPD-00). As for the decay data, half-lives, branching ratios and recoverable energy values have been replaced with those of the JENDL/FPD-00 file. The data of the photon library has been also replaced with those of the JENDL/FPD-00 file in which photon data of the nuclides without measured data are calculated with a theoretical method. Using the updated photon library, the calculation of photon spectrum at a short time after fission event is able to be made.

  8. Silicon-Light: a European FP7 Project Aiming at High Efficiency Thin Film Silicon Solar Cells on Foil

    DEFF Research Database (Denmark)

    Soppe, W.; Haug, F.-J.; Couty, P.

    2011-01-01

    Silicon-Light is a European FP7 project, which started January 1st, 2010 and aims at development of low cost, high-efficiency thin film silicon solar cells on foil. Three main routes are explored to achieve these goals: a) advanced light trapping by implementing nanotexturization through UV Nano...... calculations of ideal nanotextures for light trapping in thin film silicon solar cells; the fabrication of masters and the replication and roll-to-roll fabrication of these nanotextures. Further, results on ITO variants with improved work function are presented. Finally, the status of cell fabrication on foils...

  9. CSIR and its activities in the European Union's (EU) framework programmes (FPs): special focus on FP6

    CSIR Research Space (South Africa)

    Meese, G

    2006-02-01

    Full Text Available the CSIR has been the most successful science and technology organisation in South Africa in FP6 and is involved in the following projects: Project acronym Title Theme Co-ordinator Web site Pharma-Planta** Recombinant pharmaceuticals from plants...-Novem, The Netherlands Under development Project acronym Title Theme Co-ordinator Web site BESTUFS Best urban freight solutions 6 NEA Transport Research and Training, The Netherlands www.bestufs.net CSIR acts as a subcontractor SIMBA Strengthening road transport...

  10. Scientific Opinion on the Pest Risk Analysis on Phytophthora ramorum prepared by the FP6 project RAPRA

    DEFF Research Database (Denmark)

    Baker, R.; Candresse, T.; Dormannsné Simon, E.

    2011-01-01

    The Panel on Plant Health was asked to deliver a scientific opinion on the Pest Risk Analysis on Phytophthora ramorum prepared by the FP6 project RAPRA, taking into account comments by Member States and additional information since RAPRA. P. ramorum is the oomycete causing sudden oak death...... is a risk of further entry (of known or new lineages and/or mating types), establishment and […] impact”. It is advisable to avoid introductions of different lineages because of inherent phenotypic differences and the potential for sexual recombination. The Panel supports the management options proposed...

  11. A New Method to Extract Customer Relational Graph Based on Modified FP-Growth Algorithm%基于改进的FP-Growth算法提取客户关系图

    Institute of Scientific and Technical Information of China (English)

    汪欢文; 陆海良; 单宇翔

    2015-01-01

    利用客户关系图可以很清晰地看出企业与客户之间的各类关系,便于企业决策者采取针对性的措施来改善客户关系.该文提出了一种基于改进的FP-Growth算法进行客户关系图提取的方法,通过最小支持度寻找到所有的频繁项集,然后结合最小置信度,筛选出所需要的关联规则来提高算法的效率.本方法已应用于浙江中烟CRM系统,结果证明该改进算法有比较好的效果.%Customer relationships can be clearly seen in customer relationship graph, thus business decision-makers can take spe-cific measures to facilitate customer relationships. This paper presents an improved algorithm based on FP-Growth algorithm to ex-tract customer relationship graph. We find all frequent itemsets through minimum support, then filter out the desired association rules integrated with the minimum confidence, which can improve the efficiency of the algorithm considerably. This method has been applied to Zhejiang Tobacco CRM system, and the results show that the improved algorithm is very effective.

  12. Gr-凝聚环的小有限分次投射维数gr.fp.dimR%Small Finite Graded Projective Dimension gr. fp. dimR of Gr - Coherent Rings

    Institute of Scientific and Technical Information of China (English)

    赵巨涛

    2002-01-01

    文[1],[2]分别研究了Gr-Norether Gr-局部(半局部)环的同调维数,文章主要进一步讨论Gr-凝聚Gr-半局部环的同调性质.在§1中,主要刻画交换Gr-凝聚Gr-半局部环R的分次弱整体维数gr.gl.w.dimR;在§2中,定义了分次环R的小有限分次投射维数gr.fp.dimR.刻画了gr.fp.dimR=gr.gl. w.dimR的Gr-凝聚环.由于Gr-Norether环是Gr-凝聚的,因而本文所得的结果对于Gr-Norether环是自然成立的.同时,本文所得的结果,也可视为文[4]关于一般交换凝聚环相应结论的推广.

  13. Gr-凝聚环的小有限分次投射维数gr.fp.dimR%Small Finite Graded Projective Dimension gr.fp.dimR of Gr-Coherent Rings

    Institute of Scientific and Technical Information of China (English)

    赵巨涛; 黄寄洪

    2004-01-01

    文[1],[2]分别研究了Gr-Noether Gr-局部(半局部)环的同调维数,本文主要进一步讨论Gr-凝聚Gr-半局部环的同调性质. 在§1中,主要刻画交换Gr-凝聚Gr-半局部环R的分次弱整体维数gr.gl.w.dimR; 在§2中,定义了分次环R的小有限分次投射维数gr.fp.dimR. 刻画了gr.fp.dimR=gr.gl.w.dimR的Gr-凝聚环. 由于Gr-Noether环是Gr-凝聚的,因而本文所得的结果对于Gr-Noether环是自然成立的. 同时,本文所得的结果,也可视为文[4]关于一般交换凝聚环相应结论的推广.

  14. Reduction in camera-specific variability in [{sup 123}I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

    Energy Technology Data Exchange (ETDEWEB)

    Buchert, Ralph; Lange, Catharina [Charite - Universitaetsmedizin Berlin, Department of Nuclear Medicine, Berlin (Germany); Kluge, Andreas; Bronzel, Marcus [ABX-CRO advanced pharmaceutical services Forschungsgesellschaft m.b.H., Dresden (Germany); Tossici-Bolt, Livia [University Hospital Southampton NHS Foundation Trust, Department of Medical Physics, Southampton (United Kingdom); Dickson, John [University College London Hospital NHS Foundation Trust, Institute of Nuclear Medicine, London (United Kingdom); Asenbaum, Susanne [Medical University of Vienna, Department of Nuclear Medicine, Vienna (Austria); Booij, Jan [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Centre, Amsterdam (Netherlands); Kapucu, L. Oezlem Atay [Gazi University, Department of Nuclear Medicine, Faculty of Medicine, Ankara (Turkey); Svarer, Claus [Rigshospitalet and University of Copenhagen, Neurobiology Research Unit, Copenhagen (Denmark); Koulibaly, Pierre-Malick [University of Nice-Sophia Antipolis, Nuclear Medicine Department, Centre Antoine Lacassagne, Nice (France); Nobili, Flavio [University of Genoa, Department of Neuroscience (DINOGMI), Clinical Neurology Unit, Genoa (Italy); Pagani, Marco [CNR, Institute of Cognitive Sciences and Technologies, Rome (Italy); Karolinska Hospital, Department of Nuclear Medicine, Stockholm (Sweden); Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Sera, Terez [University of Szeged, Department of Nuclear Medicine and Euromedic Szeged, Szeged (Hungary); Tatsch, Klaus [Municipal Hospital of Karlsruhe Inc, Department of Nuclear Medicine, Karlsruhe (Germany); Borght, Thierry vander [CHU Namur, IREC, Nuclear Medicine Division, Universite catholique de Louvain, Yvoir (Belgium); Laere, Koen van [University Hospital and K.U. Leuven, Nuclear Medicine, Leuven (Belgium); Varrone, Andrea [Karolinska University Hospital, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm (Sweden); Iida, Hidehiro [National Cerebral and Cardiovascular Center - Research Institute, Osaka (Japan)

    2016-07-15

    Quantitative estimates of dopamine transporter availability, determined with [{sup 123}I]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [{sup 123}I]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis. Of 73 healthy subjects from the European Normal Control Database of [{sup 123}I]FP-CIT recruited at six centres, 70 aged between 20 and 82 years were included. SPECT images were reconstructed using the QSPECT software package which provides fully automated detection of the outer contour of the head, camera-specific correction for scatter and septal penetration by transmission-dependent convolution subtraction, iterative OSEM reconstruction including attenuation correction, and camera-specific ''to kBq/ml'' calibration. LINK and HERMES reconstruction were used for head-to-head comparison. The specific striatal [{sup 123}I]FP-CIT binding ratio (SBR) was computed using the Southampton method with binding in the whole brain, occipital cortex or cerebellum as the reference. The correlation between SBR and age was used as the primary quality measure. The fraction of SBR variability explained by age was highest (1) with QSPECT, independently of the reference region, and (2) with whole brain as the reference, independently of the reconstruction algorithm. QSPECT reconstruction appears to be useful for reduction of camera-specific intersubject variability of [{sup 123}I]FP-CIT SPECT in multisite and single-site multicamera settings. Whole brain excluding striatal binding as the reference provides more stable quantitative estimates than occipital or cerebellar binding. (orig.)

  15. No significant effects of single intravenous, single oral and subchronic oral administration of acetylcholinesterase inhibitors on striatal [{sup 123}I]FP-CIT binding in rats

    Energy Technology Data Exchange (ETDEWEB)

    Knol, R.J.J.; Booij, J. [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Center, Amsterdam (Netherlands); Graduate School of Neurosciences, Amsterdam (Netherlands); Bruin, K. de; Eck-Smit, B.L.F. van [University of Amsterdam, Department of Nuclear Medicine, Academic Medical Center, Amsterdam (Netherlands)

    2008-03-15

    [{sup 123}I]FP-CIT SPECT is a valuable diagnostic tool to discriminate Lewy body dementia from Alzheimer's dementia. To date, however, it is uncertain whether the frequently used acetylcholinesterase inhibitors (AChEIs) by demented patients, have an effect on [{sup 123}I]FP-CIT binding to dopamine transporters (DATs). Earlier animal studies showed a decline of DAT availability after acute intravenous injection of AChEIs. The aim of this study was to investigate effects of single intravenous, single oral and subchronic oral administration of AChEIs on DAT availability in the rat brain as measured by [{sup 123}I]FP-CIT. Biodistribution studies were performed in Wistar rats (n = 5-16 per group). Before [{sup 123}I]FP-CIT injection, rats were injected intravenously with a single dose of the AChEI rivastigmine (2.5 mg/kg body weight) or donepezil (0.5 mg/kg), the DAT-blocker methylphenidate (10 mg/kg) or saline. A second group was orally treated with a single dose of rivastigmine or donepezil (2.5 mg/kg), methylphenidate (10 mg/kg) or saline before injection of [{sup 123}I]FP-CIT. Studies were also performed in rats that were orally treated during 14 consecutive days with either rivastigmine (1 mg/kg daily), donepezil (1.5 mg/kg daily), methylphenidate (2.5 mg/kg) or saline. Brain parts were assayed in a gamma counter, and specific striatum/cerebellum ratios were calculated for the [{sup 123}I]FP-CIT binding to DATs. No significant effects of either single intravenous, single oral or subchronic oral administration of AChEIs on striatal FP-CIT binding could be detected. Single pretreatment with methylphenidate resulted in an expected significantly lower striatal FP-CIT binding. We conclude that in rats, single intravenous and single or subchronic oral administration of the tested AChEIs does not lead to an important alteration of [{sup 123}I]FP-CIT binding to striatal DATs. Therefore, it is unlikely that these drugs will induce large effects on the interpretation of

  16. Comparison of two neural network classifiers in the differential diagnosis of essential tremor and Parkinson's disease by {sup 123}I-FP-CIT brain SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Palumbo, Barbara [University of Perugia, Nuclear Medicine Section, Department of Surgical, Radiological and Odontostomatological Sciences, Ospedale S. Maria della Misericordia, Perugia (Italy); Fravolini, Mario Luca [University of Perugia, Department of Electronic and Information Engineering, Perugia (Italy); Nuvoli, Susanna; Spanu, Angela; Madeddu, Giuseppe [University of Sassari, Department of Nuclear Medicine, Sassari (Italy); Paulus, Kai Stephan [University of Sassari, Department of Neurology, Sassari (Italy); Schillaci, Orazio [University Tor Vergata, Department of Biopathology and Diagnostic Imaging, Rome (Italy); IRCSS Neuromed, Pozzilli (Italy)

    2010-11-15

    To contribute to the differentiation of Parkinson's disease (PD) and essential tremor (ET), we compared two different artificial neural network classifiers using {sup 123}I-FP-CIT SPECT data, a probabilistic neural network (PNN) and a classification tree (ClT). {sup 123}I-FP-CIT brain SPECT with semiquantitative analysis was performed in 216 patients: 89 with ET, 64 with PD with a Hoehn and Yahr (H and Y) score of {<=}2 (early PD), and 63 with PD with a H and Y score of {>=}2.5 (advanced PD). For each of the 1,000 experiments carried out, 108 patients were randomly selected as the PNN training set, while the remaining 108 validated the trained PNN, and the percentage of the validation data correctly classified in the three groups of patients was computed. The expected performance of an ''average performance PNN'' was evaluated. In analogy, for ClT 1,000 classification trees with similar structures were generated. For PNN, the probability of correct classification in patients with early PD was 81.9{+-}8.1% (mean{+-}SD), in patients with advanced PD 78.9{+-}8.1%, and in ET patients 96.6{+-}2.6%. For ClT, the first decision rule gave a mean value for the putamen of 5.99, which resulted in a probability of correct classification of 93.5{+-}3.4%. This means that patients with putamen values >5.99 were classified as having ET, while patients with putamen values <5.99 were classified as having PD. Furthermore, if the caudate nucleus value was higher than 6.97 patients were classified as having early PD (probability 69.8{+-}5.3%), and if the value was <6.97 patients were classified as having advanced PD (probability 88.1%{+-}8.8%). These results confirm that PNN achieved valid classification results. Furthermore, ClT provided reliable cut-off values able to differentiate ET and PD of different severities. (orig.)

  17. Is Self-Paced Instruction Really Worth It?

    Science.gov (United States)

    Roberson, J. A.; Crowe, C. T.

    1975-01-01

    Describes a self-paced, learning-for-mastery course in undergraduate fluid mechanics. Includes the method of course assessment, method of student evaluation, and a description of the instructor's role and work load. Summarizes aspects of self-paced instruction considered favorable and unfavorable. (GS)

  18. The Structure of the Heavy Calcium Isotopes and the Effective Interaction in the sd-fp Shell

    CERN Multimedia

    Dorvaux, O; Nowacki, F; Courtin, S; Marechal, F; Siiskonen, T M; Perrot, F; Pietri, S B

    2002-01-01

    Nuclei with 40 $<$ A $<$ 56, near the stability line, are very well described in the frame of the shell model. However, when the number of neutrons increases, the situation becomes more complex which explains why the interaction can be found very dissimilar within different calculations. Heavy Ca isotopes, because of the simplicity of their wave-functions, correspond to the optimal choice to fix unambiguously the interaction in this mass region.\\\\ It is proposed to measure the $\\beta$-decay of $^{51, 52, 53}$K with the help of an utmost performing neutron (TONNERRE array) and $\\gamma$- (Miniball clusters) detection, allowing efficient coincidence measurements. This will allow the lowest lying Gamow-Teller states to be located in $^{51, 52, 53}$Ca, and the still unknown properties of natural parity states to be investigated. The awaited results should allow to settle the n-n interaction in the fp shell and the Gnp matrix accross the sd and fp shells, one step farther from stability, by comparison with fu...

  19. Is binocular vision worth considering in people with low vision?

    Science.gov (United States)

    Uzdrowska, Marta; Crossland, Michael; Broniarczyk-Loba, Anna

    2014-01-01

    In someone with good vision, binocular vision provides benefits which could not be obtained by monocular viewing only. People with visual impairment often have abnormal binocularity. However, they often use both eyes simultaneously in their everyday activities. Much remains to be known about binocular vision in people with visual impairment. As the binocular status of people with low vision strongly influences their treatment and rehabilitation, it should be evaluated and considered before diagnosis and further recommendations.

  20. Self-Worth and Social Support of Children Exposed to Marital Violence

    Science.gov (United States)

    Riesen, Yuriko; Porath, Marion

    2004-01-01

    The purpose of this study was to examine the relationships among global self-worth (GSW), competencies in various domains, discrepancy between these perceptions of competence and their ratings of importance, and perceived social support of children who were exposed to marital violence using Harter's (1985a, 1985b) theoretical model. Participants…

  1. WORTH property, Garc\\'{i}a-Falset coefficient and Opial property of infinite sums

    OpenAIRE

    Hardtke, Jan-David

    2014-01-01

    We prove some results concerning the WORTH property and the Garc\\'{i}a-Falset coefficient of absolute sums of infinitely many Banach spaces. The Opial property/uniform Opial property of infinite $\\ell^p$-sums is also studied and some properties analogous to the Opial property/uniform Opial property for Lebesgue-Bochner spaces $L^p(\\mu,X)$ are discussed.

  2. Long-term investment and net-worth building with limited contract enforcement

    NARCIS (Netherlands)

    Uras, Burak

    This paper develops a firm dynamics model augmented with an endogenous net-worth-building feature at the firm level and investigates how opportunities for entrepreneurs to accumulate wealth can mitigate the implications of limited enforceability for resource allocation, productivity, and

  3. A World Worth Living in ICAE 8th World Assembly Declaration (June 2011)

    Science.gov (United States)

    Adult Learning, 2012

    2012-01-01

    This article presents the International Council of Adult Education (ICAE) 8th World Assembly Declaration (June 2011). This declaration focuses on adult educators' conviction in the possibility of a "world worth living in," and their declaration of their collective determination to work towards making it a reality all around the planet.

  4. 75 FR 17691 - Foreign-Trade Zone 196 - Fort Worth, Texas, Application for Manufacturing Authority, ATC...

    Science.gov (United States)

    2010-04-07

    ... Authority, ATC Logistics & Electronics (Cell Phone Kitting and Distribution), Fort Worth, Texas An application has been submitted to the Foreign-Trade Zones Board (the Board) by ATC Logistics & Electronics... kitting and distribution of cell phones. Components and materials sourced from abroad (representing 96% of...

  5. Older Adults' Perceived Changes in Physical Self-Worth Associated with Resistance Training

    Science.gov (United States)

    Dionigi, Rylee A.; Cannon, Jack

    2009-01-01

    Using Sonstroem, Harlow, and Josephs' (1994) expanded version of the Exercise and Self-Esteem Model (EXSEM; Sonstroem & Morgan, 1989), we explored how 9 older adults (6 women and 3 men, aged 65-72 years) involved in a resistance training program experienced and perceived changes in physical self-worth (i.e., improved strength, functional…

  6. Social Support and Neighborhood Stressors among African American Youth: Networks and Relations to Self-Worth

    Science.gov (United States)

    McMahon, Susan D.; Felix, Erika D.; Nagarajan, Thara

    2011-01-01

    Although neighborhood stressors have a negative impact on youth, and social support can play a protective role, it is unclear what types and sources of social support may contribute to positive outcomes among at-risk youth. We examined the influences of neighborhood disadvantage and social support on global self-worth among low-income, urban…

  7. 38 CFR 3.274 - Relationship of net worth to pension entitlement.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Relationship of net worth to pension entitlement. 3.274 Section 3.274 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS ADJUDICATION Pension, Compensation, and Dependency and Indemnity Compensation Regulations...

  8. Value and Opportunity: Comparable Pay for Comparable Worth. Series on Public Issues No. 10.

    Science.gov (United States)

    Walker, Deborah

    In this booklet, one of a series intended to apply economic principles to major social and political issues, an argument is presented against comparable pay for comparable worth policies for women. Separate subsections present opposing viewpoints on this controversial issue as well as an examination of whether legislation has been a…

  9. Experience and net worth affects optimality in a motor decision task.

    Science.gov (United States)

    Neyedli, Heather F; Welsh, Timothy N

    2015-01-01

    Previous research has shown in a motor decision task involving a target (yielding a reward) and overlapping penalty area (yielding a loss), people initially aim closer to the penalty area than optimal. This risky strategy may be adopted to increase target hits, thereby increasing net worth. The purpose of the current study was to determine whether the starting net worth level (either 5,000 or 0 points) affected the influence of task experience on endpoint selection. It was hypothesized the 5,000-point group should adopt a less risky strategy and aim further from the penalty area than those with 0 points. Net worth affected participants' initial endpoint where the 5,000-point group aimed further from the penalty circle, and closer to the optimal endpoint, than the 0-point group. The 0-point group adapted their endpoint over the course session to aim closer to the optimal endpoint whereas no such change was seen in the 5,000-point group. The results show that changing the participants' reference point through initial net worth can affect the optimality of participants' endpoint and how endpoints change with experience.

  10. Troubled Diversities, Multiple Identities and the Relevance of Royce: What Makes a Community Worth Caring about?

    Science.gov (United States)

    Raposa, Michael

    2012-01-01

    This article raises questions about what it means to be a diverse academic community and about why such diversity is worth struggling to achieve. The controversial arguments of Walter Benn Michaels are critically examined as a stimulus and prelude to considering the more constructive perspectives supplied by Amartya Sen and Josiah Royce. Royce's…

  11. Environmental Assessment for EOD Stand-Up at NAS Fort Worth JRB

    Science.gov (United States)

    2012-03-01

    herbaceous, frequently mowed, lawn areas (NAS Fort Worth JRB, 2004a). These areas provide minimal habitat value for native species of flora and fauna...Jacinto Austin, TX 78701 Mark Wolfe State Historic Preservation Officer Texas Historical Commission 1511 Colorado Austin, TX 78701 Local

  12. Self in Self-Worth Protection: The Relationship of Possible Selves and Self-Protective Strategies

    Science.gov (United States)

    Seli, Helena; Dembo, Myron H.; Crocker, Stephen

    2009-01-01

    This study examined community college students' future-related self-concept, termed "possible selves," in relationship to their current academic behavior with a focus on self-worth protective strategies. As demonstrated via hierarchical regression, possible selves added to understanding the students' self-protective behavior above and beyond their…

  13. WORTH property, Garc\\'{i}a-Falset coefficient and Opial property of infinite sums

    OpenAIRE

    Hardtke, Jan-David

    2014-01-01

    We prove some results concerning the WORTH property and the Garc\\'{i}a-Falset coefficient of absolute sums of infinitely many Banach spaces. The Opial property/uniform Opial property of infinite $\\ell^p$-sums is also studied and some properties analogous to the Opial property/uniform Opial property for Lebesgue-Bochner spaces $L^p(\\mu,X)$ are discussed.

  14. Partnership tools for health promotion: are they worth the effort?

    Science.gov (United States)

    Joss, Nerida; Keleher, Helen

    2011-09-01

    In health promotion and community sector programs, working through partnerships has become a key strategy for capacity building and infrastructure development that is intended to achieve better health outcomes. Government and funding agencies are providing significant support for partnership work in the apparent belief that partnerships are more likely to improve sustainability of programs and their outcomes than single agencies working alone. Online partnership analysis tools are designed for organisations to measure the effectiveness of their collaborative endeavours, and to demonstrate to funding bodies that the partnership was worthwhile. The tools are predominantly self-assessment evaluation tools but there is a lack of clarity about what these tools actually set out to measure. Self-assessment tools assist partners to recognise strengths and weaknesses in their practice, but analysis of their intentions indicates that there are significant problems with the 'snapshot' data that is generated in terms of analysing effectiveness. Partnership work is complex, dynamic and context specific with varying synergistic rewards which cannot always be represented in survey tools. This article reports analysis of online self-assessment partnership tools which have data-generating capacity, to determine just what they measure and to understand how effective they can be in evaluating collaborative practice. Criteria for analysis were developed from a review of the existing literature. The review and analysis has highlighted that practitioners must consider what they are measuring and for what purpose they seek to evaluate before utilising and implementing a partnership analysis tool.

  15. 75 FR 17691 - Foreign-Trade Zone 196 - Fort Worth, Texas, Application for Temporary/Interim Manufacturing...

    Science.gov (United States)

    2010-04-07

    ... Manufacturing Authority, ATC Logistics & Electronics (Cell Phone Kitting and Distribution), Fort Worth, Texas An... Logistics & Electronics, operator of Site 2, FTZ 196, Fort Worth, Texas, requesting temporary/ interim... the kitting and distribution of cell phones (HTSUS 8517.12, duty free) under T/IM procedures at its...

  16. Is Self-Worth Protection Best Regarded as Intentional Self-Handicapping Behaviour or an Outcome of Choking under Pressure?

    Science.gov (United States)

    Thompson, Ted; Dinnel, Dale L.

    2007-01-01

    Self-worth protective students characteristically perform poorly when they anticipate that poor performance is likely to reveal low ability, yet perform well in situations that involve little threat to self-worth. The present study sought a further understanding of this variable pattern of achievement, assessing two possibilities: (1) that the…

  17. 75 FR 79302 - Determination of Nonattainment and Reclassification of the Dallas/Fort Worth 1997 8-Hour Ozone...

    Science.gov (United States)

    2010-12-20

    ... AGENCY 40 CFR Part 81 Determination of Nonattainment and Reclassification of the Dallas/Fort Worth 1997 8.... SUMMARY: EPA is finalizing its determination that the Dallas/Fort Worth (DFW) moderate 8-hour ozone... review of complete, quality assured and certified ambient air quality monitoring data for the 2007-2009...

  18. 75 FR 47746 - Determination of Nonattainment and Reclassification of the Dallas/Fort Worth 1997 8-hour Ozone...

    Science.gov (United States)

    2010-08-09

    ... AGENCY 40 CFR Part 81 Determination of Nonattainment and Reclassification of the Dallas/Fort Worth 1997 8.... SUMMARY: EPA is proposing to determine that the Dallas/Fort Worth (DFW) moderate 8-hour ozone... complete, quality assured and certified ambient air quality monitoring data for the 2007-2009 monitoring...

  19. 78 FR 41911 - Foreign-Trade Zone 39-Dallas-Fort Worth, Texas; CSI Calendering, Inc. (Rubber Coated Textile...

    Science.gov (United States)

    2013-07-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 39--Dallas-Fort Worth, Texas; CSI Calendering, Inc. (Rubber Coated Textile Fabric); Arlington, Texas On March 4, 2013, the Dallas/Fort Worth International...

  20. Life worth living for caregiving and caregiver burden among Japanese caregivers of the disabled elderly in Japan.

    Science.gov (United States)

    Okamoto, Kazushi; Momose, Yumiko; Fujino, Ayumi; Osawa, Yukari

    2009-01-01

    The aim of this study is to determine the relationship between life worth living and caregiver burden among caregivers in Japan. We used 111 caregivers of frail elders who completed a self-administered questionnaire including the 8 items developed by Arai et al. (J-ZBI) used as a scale to measure subjective burdens and psychological factors used as covariates other than life worth living. Total score (0-32) of the J-ZBI was dichotomized into "high burden" (> or =21 points) and "low burden" (worth living was significantly associated with caregiver burden. The direct effect of life worth living on caregiver burden (92.9%) was much greater than the indirect effect (7.1%). Our findings suggest that the increase of the sense of life worth living may play an important role in the prevention of the development of caregiver burden.

  1. Data-worth analysis through probabilistic collocation-based Ensemble Kalman Filter

    Science.gov (United States)

    Dai, Cheng; Xue, Liang; Zhang, Dongxiao; Guadagnini, Alberto

    2016-09-01

    We propose a new and computationally efficient data-worth analysis and quantification framework keyed to the characterization of target state variables in groundwater systems. We focus on dynamically evolving plumes of dissolved chemicals migrating in randomly heterogeneous aquifers. An accurate prediction of the detailed features of solute plumes requires collecting a substantial amount of data. Otherwise, constraints dictated by the availability of financial resources and ease of access to the aquifer system suggest the importance of assessing the expected value of data before these are actually collected. Data-worth analysis is targeted to the quantification of the impact of new potential measurements on the expected reduction of predictive uncertainty based on a given process model. Integration of the Ensemble Kalman Filter method within a data-worth analysis framework enables us to assess data worth sequentially, which is a key desirable feature for monitoring scheme design in a contaminant transport scenario. However, it is remarkably challenging because of the (typically) high computational cost involved, considering that repeated solutions of the inverse problem are required. As a computationally efficient scheme, we embed in the data-worth analysis framework a modified version of the Probabilistic Collocation Method-based Ensemble Kalman Filter proposed by Zeng et al. (2011) so that we take advantage of the ability to assimilate data sequentially in time through a surrogate model constructed via the polynomial chaos expansion. We illustrate our approach on a set of synthetic scenarios involving solute migrating in a two-dimensional random permeability field. Our results demonstrate the computational efficiency of our approach and its ability to quantify the impact of the design of the monitoring network on the reduction of uncertainty associated with the characterization of a migrating contaminant plume.

  2. Current status and Future Works in Dynamic Control Rod Worth Measurement Method in KOREA

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eun-ki; Shin, Ho-chul [Korea Hydro Nuclear Power Co. Central Research Inst, Daejeon (Korea, Republic of)

    2015-10-15

    Actually all ex-core detector signal data processing and extracting the final conclusion about the single control bank was performed by the 3rd generation of Digital Reactivity Computer System (DRCS). From 2006 to 2016, about 250 control bank worths were measured and the difference between measured and calculated worth of individual bank were several % and total rod worth differences of each cycle were less than 3%. However there were a few odd cases showing the individual difference greater than 15% which is the criteria. And some OPR1000 nuclear power plants built recently use fission chambers instead of traditional uncompensated ion chambers. To consider those conditions, any modification of the DCRM method and DRCS were requested. In this paper, short description about DCRM method, current status of DCRM modification and future works are discussed. About 10 cases among about 250 control bank worth measurement with original DCRM method with UIC signals result in very heavy fluctuation on reactivity curve and the difference approaches 15%, the individual limit. The electrometer signals processing method were the main cause. To overcome this problem, a modified reactivity computer system using own current treatment logic was designed. It shows the reactivity fluctuation can be reduced dramatically in case of UIC signal. Recently the modified DRCS coupled INVESE code applied Westinghouse 2 Loop plant and gave very good results except a control bank whose measured rod worth was shown of 18% difference from the estimated value. The results were same for three repeat tests. All possible causes are examined from computer codes to detail data acquisition system.

  3. Comparative Performance Evaluation of Large FPGAs with CNFET-and CMOS-based Switches in Nanoscale

    Institute of Scientific and Technical Information of China (English)

    Mohammad Hossein Moaiyeri; Ali Jahaniana; Keivan Navi

    2011-01-01

    Routing resources are the major bottlenecks in improving the performance and power consumption of the current FPGAs. Recently reported researches have shown that carbon nanotube field effect transistors (CNFETs) have considerable potentials for improving the delay and power consumption of the modern FP-GAs. In this paper, hybrid CNFET-CMOS architecture is presented for FPGAs and then this architecture is evaluated to be used in modern FPGAs. In addition, we have designed and parameterized the CNFET-based FPGA switches and calibrated them for being utilized in FPGAs at 45 nm, 22 nm and 16 nm technology nodes. Simulation results show that the CNFET-based FPGA switches improve the current FPGAs in terms of per-formance, power consumption and immunity to process and temperature variations. Simulation results and analyses also demonstrate that the performance of the FPGAs is improved about 30%, on average and the average and leakage power consumptions are reduced more than 6% and 98% respectively when the CNFET switches are used instead of MOSFET FPGA switches. Moreover, this technique leads to more than 20.31%smaller area. It is worth mentioning that the advantages of CNFET-based FPGAs are more considerable when the size of FPGAs grows and also when the technology node becomes smaller.

  4. Office-based vascular lab: is it worth the effort?

    Science.gov (United States)

    Mansour, M Ashraf; Zwolak, Robert M

    2009-03-01

    The vascular laboratory is an essential part of any contemporary clinical vascular practice. The prototype of the vascular laboratory consisted mainly of instruments designed to understand the hemodynamics of the vascular tree. Earlier versions also played important roles in clinical research. Currently, sophisticated imaging equipments enable clinicians to evaluate the whole range of arterial and venous diseases in the outpatient setting. Both patients and physicians have found this to be very practical and convenient. Furthermore, income generated from performing diagnostic tests in the vascular laboratory helps support a variety of clinical activities and research. However, recent cost-cutting measures by medical insurance carriers are threatening the viability of office-based vascular laboratories

  5. Data acquisition for conservation assessments: is the effort worth it?

    Science.gov (United States)

    Hermoso, Virgilio; Kennard, Mark J; Linke, Simon

    2013-01-01

    When identifying conservation priorities, the accuracy of conservation assessments is constrained by the quality of data available. Despite previous efforts exploring how to deal with imperfect datasets, little is known about how data uncertainty translates into errors in conservation planning outcomes. Here, we evaluate the magnitude of commission and omission error, effectiveness and efficiency of conservation planning outcomes derived from three datasets with increasing data quality. We demonstrate that investing in data acquisition might not always be the best strategy as the magnitude of errors introduced by new sites/species can exceed the benefits gained. There was a trade-off between effectiveness and efficiency due to poorly sampled rare species. Given that data acquisition is limited by the high cost and time required, we recommend focusing on improving the quality of data for those species with the highest level of uncertainty (rare species) when acquiring new data.

  6. Dopaminergic dysfunction and psychiatric symptoms in movement disorders: a {sup 123}I-FP-CIT SPECT study

    Energy Technology Data Exchange (ETDEWEB)

    Di Giuda, Daniela; Cocciolillo, Fabrizio; Bruno, Isabella; Giordano, Alessandro [Universita Cattolica del Sacro Cuore, Istituto di Medicina Nucleare, Rome (Italy); Camardese, Giovanni; Pucci, Lorella; Janiri, Luigi [Universita Cattolica del Sacro Cuore, Istituto di Psichiatria e Psicologia, Rome (Italy); Bentivoglio, Anna Rita; Guidubaldi, Arianna [Universita Cattolica del Sacro Cuore, Istituto di Neurologia, Rome (Italy); Fasano, Alfonso [Universita Cattolica del Sacro Cuore, Istituto di Neurologia, Rome (Italy); AFaR-Associazione Fatebenefratelli per la Ricerca, Rome (Italy)

    2012-12-15

    Psychiatric symptoms frequently occur in patients with movement disorders. They are not a mere reaction to chronic disability, but most likely due to a combination of psychosocial factors and biochemical dysfunction underlying the movement disorder. We assessed dopamine transporter (DAT) availability by means of {sup 123}I-FP-CIT SPECT, and motor and psychiatric features in patients with Parkinson's disease, primary dystonia and essential tremor, exploring the association between SPECT findings and symptom severity. Enrolled in the study were 21 patients with Parkinson's disease, 14 patients with primary dystonia and 15 patients with essential tremor. The severity of depression symptoms was assessed using the Hamilton depression rating scale, anxiety levels using the Hamilton anxiety rating scale and hedonic tone impairment using the Snaith-Hamilton pleasure scale. Specific {sup 123}I-FP-CIT binding in the caudate and putamen was calculated based on ROI analysis. The control group included 17 healthy subjects. As expected, DAT availability was significantly decreased in patients with Parkinson's disease, whereas in essential tremor and dystonia patients it did not differ from that observed in the control group. In Parkinson's disease patients, an inverse correlation between severity of depression symptoms and DAT availability in the left caudate was found (r = -0.63, p = 0.002). In essential tremor patients, levels of anxiety symptoms were inversely correlated with DAT availability in the left caudate (r = -0.69, p = 0.004). In dystonia patients, the severities of both anxiety and depression symptoms were inversely associated with DAT availability in the left putamen (r = -0.71, p = 0.004, and r = -0.75, p = 0.002, respectively). There were no correlations between psychometric scores and {sup 123}I-FP-CIT uptake ratios in healthy subjects. We found association between presynaptic dopaminergic function and affective symptoms in different movement

  7. 重症烧伤患者能量消耗与需求平衡:值得深入研究的问题%Evaluation of the balance between energy supplement and consumption in patients with serious burn: a problem worth further investigation

    Institute of Scientific and Technical Information of China (English)

    彭曦

    2013-01-01

    The energy expenditure of burn patients can be determined accurately by indirect calorimetry measurement,or estimated approximately with energy expenditure equations.However,the energy requirement is not entirely equal to energy expenditure in the whole process of burn injury.The energy consumption induced by hypercatabolism is increased significantly,and on the other hand,the ability of nutrient absorption and anabolism decreased remarkably in the early phase of burn injury,thus leading to imbalance between energy consumption and demand.However,energy supplement as calculated according to energy consumption may induce overfeeding in the early phase of burn injury.Excessive nutrients intake can not be fully utilized to decrease hypermetabolic reaction,but it might exacerbate metabolic disorder.Therefore,the energy supplement should be lower than energy consumption during the early stage of burns.With the advance of disease course,the internal environment becomes stable gradually,ending in a balance between anabolism and catabolism.Energy supplement should be increased gradually according to energy consumption.During the convalescent period,anabolic metabolism exceeds catabolic metabolism,therefore the quantity of energy supplement should be moderately higher than that of energy consumption.Thus,the energy consumption and energy supplement may reach a balance during the whole course of treatment.The purpose of the article is to analyze and discuss how to estimate energy expenditure precisely and evaluate energy requirement correctly,in order to reach a balance between energy consumption and supplement during a long course of treatment for severe burn patients.

  8. Double row repair: is it worth the hassle?

    Science.gov (United States)

    Papalia, Rocco; Franceschi, Francesco; Del Buono, Angelo; Zampogna, Biagio; Maffulli, Nicola; Denaro, Vincenzo

    2011-12-01

    In the operative management of rotator cuff disease, comparable functional results have been reported after open or mini-open repair and arthroscopic fixation. Surgical repair aims to re-establish an anatomical configuration of the tendon-bone construct for restoring its mechanical performance. Single row repair is the most commonly used technique, but recently some authors have proposed to re-establish the rotator cuff footprint with 2 rows of suture anchors ("double row" repair). In regard to imaging assessment, at time zero double row repair results being more anatomic and allows for structurally sound restoration of the rotator cuff footprint. However, this does not seem to translate into superior clinical outcomes for the double row repair when evaluating all different sizes of rotator cuff tears as a whole. The scientific basis for recommending single or double row repair as preferred treatment for patients with rotator cuff tear is questionable, as minimal differences have been measured on clinical and functional rating scales.

  9. Animal Welfare: Freedoms, Dominions and "A Life Worth Living".

    Science.gov (United States)

    Webster, John

    2016-05-24

    This opinion paper considers the relative validity and utility of three concepts: the Five Freedoms (FF), Five Domains (FD) and Quality of Life (QoL) as tools for the analysis of animal welfare. The aims of FF and FD are different but complementary. FD seeks to assess the impact of the physical and social environment on the mental (affective) state of a sentient animal, FF is an outcome-based approach to identify and evaluate the efficacy of specific actions necessary to promote well-being. Both have utility. The concept of QoL is presented mainly as a motivational framework. The FD approach provides an effective foundation for research and evidence-based conclusions as to the impact of the things we do on the mental state of the animals in our care. Moreover, it is one that can evolve with time. The FF are much simpler. They do not attempt to achieve an overall picture of mental state and welfare status, but the principles upon which they are based are timeless. Their aim is to be no more than a memorable set of signposts to right action. Since, so far as the animals are concerned, it is not what we think but what we do that counts, I suggest that they are likely to have a more general impact.

  10. NBS for Drought risks reduction in the Algarve (Portugal): selected achievements from PT FCT ProWaterMan and from EU FP7 MARSOL projects

    Science.gov (United States)

    Lobo-Ferreira, João-Paulo

    2017-04-01

    region. It included the evaluation of willingness of farmers to collaborate and pay for the use of Managed Aquifer Recharge (MAR) as a nature-based solution to minimize the drought impacts and to manage flood risk in the area. Close cooperation has been established between EIP Water Action Group MARsolutions and FP7 MARSOL INNO_DEMO (http://www.eip-water.eu/close-cooperation-between-eip-marsolutions-and-fp7-marsol-inno-demo-project ). In http://www.eip-water.eu/sites/default/files/Rel%20101_15.pdf a LNEC report is available, presenting a descriptive analysis of the responses to a survey about protection and preservation of groundwater conducted with a sample of Portuguese farmers of the Algarve region. It is possible that Direção Regional de Agricultura e Pescas do Algarve is willing to participate on the implementation the nature-based solutions as they will decrease the risk for agriculture losses. The Portuguese Water Agency has precipitation and flow bulletins for the Algarve, e.g. for Faro and Albufeira areas, in http://snirh.pt/index.php?idMain=1&idItem=1.1 . Concerning the climate change impact in Querença-Silves (QS) Aquifer, LNEC/University of Algarve MARSOL project teams presented descriptions regarding respectively groundwater recharge and flow simulations of future scenarios. E.g. Stigter et al. (2009, 2014) summarized achieved conclusions were "(1) (2020-2050) changes in recharge, particularly due to a reduction in autumn rainfall resulting in a longer dry period. More frequent droughts are predicted at the QS aquifer; (2) toward the end of the century (2069-2099), results indicate a significant decrease (mean 25 %) in recharge at QS aquifer, with an high decrease in absolute terms (mean 134 mm/year); and, (3) scenario modelling of groundwater flow shows its response to the predicted decreases in recharge and increases in pumping rates, with strongly reduced outflow into the coastal wetlands, whereas changes due to sea level rise are negligible". These

  11. Computational Study of Absorption Spectra of the Photoconvertible Fluorescent Protein EosFP in Different Protonation States.

    Science.gov (United States)

    Imhof, Petra

    2012-11-13

    Absorption spectra of the green-to-red convertible fluorescent protein EosFP have been computed in a hybrid quantum mechanical/molecular mechanical (QM/MM) framework. The experimentally observed absorption maximum at ∼390 nm is well reproduced by the protein with a neutral chromophore, and the anionic form is computed to absorb close to the experimentally determined maximum at ∼500 nm. Absorption of a zwitterionic form is calculated to lie in the same spectral region; however, this species cannot be unambiguously assigned to the experimental spectra. Variation of the protonation states of residues surrounding the chromophore do not have significant impact on the positions of the absorption maxima. In particular, protonation of Glu212 leaves the calculated spectra largely unaffected. This is consistent with the spectra of the E212Q mutant, which differ from the wild-type spectra only in the intensities but not in the positions of the absorption bands.

  12. Study of the electronic and magnetic properties of EuAlO{sub 3} using FP-LAPW method

    Energy Technology Data Exchange (ETDEWEB)

    Sandeep,, E-mail: sndp.chettri@gmail.com; Shankar, A.; Rai, D. P.; Thapa, R. K. [Department of Physics, Mizoram University, Aizawl, Mizoram, India, 796004 (India); Ghimire, M. P. [National Institute for Material Sciences, Tsukuba (Japan)

    2015-05-15

    The electronic and magnetic properties of EuAlO{sub 3} is calculated by first-principles full-potential linearized augmented plane wave (FP-LAPW) method based on density functional theory (DFT). Density of states (DOS), magnetic moments and band structures of the systems are presented. For the exchange and correlation energy, local spin density approximation (LSDA+U) with the inclusion of Hubbard potential U is used. Our calculation showed an indirect band gap of the order of 4 eV for EuAlO{sub 3} in the spin down channel of the DOS and band structures supporting HMF nature of the system. The effective magnetic moment of 6.00 µ{sub B} also supported the above conclusion with an integral value. The DOS of Eu were found responsible for the HMF nature of the system.

  13. Valorisation of crude glycerol through biological conversion into bioplastics and biofuels in the frame of an FP7 project

    DEFF Research Database (Denmark)

    Varrone, Cristiano; Gavala, Hariklia N.

    for 2011 was over 8.6 million metric tons, but to date an effective use for the glycerol derived from biodiesel production does not exist on the market. In fact, even though high purity glycerol can be used in the cosmetic and pharmaceutical industry, crude glycerol derived from biodiesel production has...... is the valorisation of glycerol streams generated during the biodiesel production process, using microbial mixed culture (MMC) technology. The use of bioconversion into high-value products represents a promising route to achieve economic viability in the biofuel industry. Until now there have been several studies...... of a broader European strategy, in good synergy with other on-going FP7 projects, which can contribute to achieve new solutions for a knowledge-based economy, increasing the economic viability of the biodiesel industry, and developing new international collaborations....

  14. Trojan Horse measurement of the {sup 18}F(p, α){sup 15}O astrophysical S(E)-factor

    Energy Technology Data Exchange (ETDEWEB)

    Pizzone, R.G. [Texas A and M University, Cyclotron Institute, College Station, TX (United States); INFN, Laboratori Nazionali del Sud, Catania (Italy); Roeder, B.T.; McCleskey, M. [Texas A and M University, Cyclotron Institute, College Station, TX (United States); Trache, L. [Texas A and M University, Cyclotron Institute, College Station, TX (United States); IFIN-HH, Bucharest-Magurele (Romania); Tribble, R.E. [Texas A and M University, Cyclotron Institute, College Station, TX (United States); Brookhaven National Laboratory, Upton, New York (United States); Spitaleri, C.; Indelicato, I.; Rapisarda, G.G.; Sparta, R. [INFN, Laboratori Nazionali del Sud, Catania (Italy); Universita degli Studi di Catania, Dipartimento di Fisica e Astronomia, Catania (Italy); Bertulani, C.A. [Texas A and M University-Commerce, Department of Physics and Astronomy, Commerce (United States); Cherubini, S. [INFN, Laboratori Nazionali del Sud, Catania (Italy); Brookhaven National Laboratory, Upton, New York (United States); Gulino, M. [INFN, Laboratori Nazionali del Sud, Catania (Italy); KORE University, Enna (Italy); La Cognata, M. [INFN, Laboratori Nazionali del Sud, Catania (Italy); Lamia, L. [Universita degli Studi di Catania, Dipartimento di Fisica e Astronomia, Catania (Italy)

    2016-02-15

    Crucial information on novae nucleosynthesis is linked to the abundance of {sup 18}F, which, due to great improvements in gamma-ray astronomy, can be detected in explosive environments. Therefore, the reaction network producing and destroying this radioactive isotope has been extensively studied in the last years. Among those reactions, the {sup 18}F(p, α){sup 15}O cross section has been measured by means of several dedicated experiments, both using direct and indirect methods. The presence of resonances in the energy region of astrophysical interest has been reported by many authors. In the present work a report on a recent experiment performed via the Trojan Horse Method (THM) is presented and the results are given and compared with the ones known in the literature, both direct and indirect. Data arising from THM measurements are then averaged and the reaction rate calculated in the novae energy range. (orig.)

  15. Prepulse Inhibition is Associated with Attention, Processing Speed, and 123I-FP-CIT SPECT in Parkinson's Disease

    DEFF Research Database (Denmark)

    Zoetmulder, Marielle; Biernat, Heidi B; Nikolic, Miki;

    2014-01-01

    cognitive information processing deficits such as slowed processing speed. Parkinson's disease is characterised by the degeneration of the midbrain dopaminergic system and is associated with cognitive dysfunction, including slowed information processing. Although sensorimotor processes in Parkinson......'s disease have been extensively studied in relation to motor function, less is known about the potential role of sensorimotor processes in cognitive function. Objective: We investigated the relationship between prepulse inhibition, cognition and nigrostriatal dysfunction, as measured with 123I...... performed better on cognitive measures tapping attention and processing speed than patients with a lower level of prepulse inhibition group. Furthermore, there were significant correlations between prepulse inhibition and 123I-FP-CIT uptake in the striatum. Conclusions: Our results suggest that the level...

  16. Making Use of the Latest Earth Observation Datasets from Copernicus Programme: The SAFI EU-FP7 Project

    Science.gov (United States)

    Vincent, Chloe; Mangin, Antoine; Bryere, Philippe; Serra, Romain; Sicard, Pierre; Lesne, Olivia; Scarrott, Rory; Dunne, Declan; Gault, Jeremy; Lecouffe, Catherine; Rougier, Antoine; Jarry, Etienne; Morales, Jesus; Moreno, Oscar; Duque Perea, Raquel; Jimenez, Carlos; Martinez, Ines; Gaspar, Miguel; Rufino, Marta; Santos, Miguel A.; Garrido, Susana; Bugalho, Lourdes; Marques, Vitor; Shorten, Marc; Smith, Catherine; Maguire, Julie; Amine Taji, Mohamed

    2016-08-01

    The EU-FP7 funded project SAFI ("Supporting our Aquaculture and Fisheries Industries", www.safiservices.eu) is primary focused on the exploitation of Earth Observation (EO) data resources, is specifically targeting the support of fisheries and aquaculture industries in our ocean and near-shore areas. The initiative aims at providing information assistance for marine aquaculture deployment (optimization of cage location with respect to environmental and ecological context) and environmental monitoring during operations. It also targets supporting fisheries providing informative indicator products developed through exploitation of Ocean Colour and Sea Surface Temperature data to derive correlations between the environmental situation and the biological status (maturation stage, recruitment and abundance rates) of the fish and shellfish studied. Developed in close collaboration with key stakeholders in the aquaculture and fishery sectors, the SAFI project proposes synthetic indicators for the species of critical importance to regional fisheries and aquaculture sectors.

  17. Coulomb energy difference as a probe of isospin-symmetry breaking in the upper fp-shell nuclei

    CERN Document Server

    Kaneko, K; Sun, Y; Tazaki, S; de Angelis, G

    2012-01-01

    The anomaly in Coulomb energy differences (CED) between the isospin T=1 states in the odd-odd N=Z nucleus 70Br and the analogue states in its even-even partner 70Se has remained a puzzle. This is a direct manifestation of isospin-symmetry breaking in effective nuclear interactions. Here, we perform large-scale shell-model calculations for nuclei with A=66-78 using the new filter diagonalization method based on the Sakurai-Sugiura algorithm. The calculations reproduce well the experimental CED. The observed negative CED for A=70 are accounted for by the cross-shell neutron excitations from the fp-shell to the g9/2 intruder orbit with the enhanced electromagnetic spin-orbit contribution at this special nucleon number.

  18. Physician Assistant Model for Lung Procurements: A Paradigm Worth Considering

    Science.gov (United States)

    Costa, Joseph; D’Ovidio, Frank; Bacchetta, Matthew; LaVelle, Matthew; Singh, Gopal; Sonett, Joshua R.

    2017-01-01

    evaluation of lung allografts. PMID:24090582

  19. Glaciotectonic deformation and reinterpretation of the Worth Point stratigraphic sequence: Banks Island, NT, Canada

    Science.gov (United States)

    Vaughan, Jessica M.; England, John H.; Evans, David J. A.

    2014-05-01

    Hill-hole pairs, comprising an ice-pushed hill and associated source depression, cluster in a belt along the west coast of Banks Island, NT. Ongoing coastal erosion at Worth Point, southwest Banks Island, has exposed a section (6 km long and ˜30 m high) through an ice-pushed hill that was transported ˜ 2 km from a corresponding source depression to the southeast. The exposed stratigraphic sequence is polydeformed and comprises folded and faulted rafts of Early Cretaceous and Late Tertiary bedrock, a prominent organic raft, Quaternary glacial sediments, and buried glacial ice. Three distinct structural domains can be identified within the stratigraphic sequence that represent proximal to distal deformation in an ice-marginal setting. Complex thrust sequences, interfering fold-sets, brecciated bedrock and widespread shear structures superimposed on this ice-marginally deformed sequence record subsequent deformation in a subglacial shear zone. Analysis of cross-cutting relationships within the stratigraphic sequence combined with OSL dating indicate that the Worth Point hill-hole pair was deformed during two separate glaciotectonic events. Firstly, ice sheet advance constructed the hill-hole pair and glaciotectonized the strata ice-marginally, producing a proximal to distal deformation sequence. A glacioisostatically forced marine transgression resulted in extensive reworking of the strata and the deposition of a glaciomarine diamict. A readvance during this initial stage redeformed the strata in a subglacial shear zone, overprinting complex deformation structures and depositing a glaciotectonite ˜20 m thick. Outwash channels that incise the subglacially deformed strata record a deglacial marine regression, whereas aggradation of glaciofluvial sand and gravel infilling the channels record a subsequent marine transgression. Secondly, a later, largely non-erosive ice margin overrode Worth Point, deforming only the most surficial units in the section and depositing a

  20. Siderophore production by Pseudomonas aeruginosa FP6, a biocontrol strain for Rhizoctonia solani and Colletotrichum gloeosporioides causing diseases in chilli

    Directory of Open Access Journals (Sweden)

    Bakthavatchalu Sasirekha

    2016-07-01

    Full Text Available Siderophores are compounds secreted under low iron stress, which act as specific ferric iron chelating agents. Owing to their potential in the biological control of fungal phytopathogens, they may be used as an alternative strategy to chemical control. Pseudomonas aeruginosa FP6, previously isolated from rhizospheric soil samples was screened for its siderophore production on a chrome-azurol S agar plate. Change in the colour of the chrome-azurol S agar from blue to orange red confirmed the siderophore producing ability of P. aeruginosa FP6. The effects of various physicochemical parameters on siderophore production were studied. The maximum siderophore production was obtained in succinate medium (125 μM followed by King's B medium (105 μM. The presence of sucrose and mannitol increased the siderophore production. Yeast extract proved to be the most suitable nitrogen source. Media supplemented with Pb2+, Mn2+ and Mg2+ showed appreciable siderophore production as well as growth of cultures. An increase in the iron concentration favoured growth but substantially reduced siderophore production. The strain when tested for its in-vitro antagonistic activity against Rhizoctonia solani and Colletotrichum gloeosporioides on King's B media, with and without FeCl3, showed a significant reduction in R. solani growth with FeCl3 supplementation compared to the control (without FeCl3, suggesting the role of siderophore mediated antagonism of R. solani. Antifungal activity was not influenced by FeCl3 in the case of C. gloeosporioides, suggesting the presence of other antagonistic mechanisms.

  1. New Improved Indirect Measurement of the 19F(p, α)16O Reaction at Energies of Astrophysical Relevance

    Science.gov (United States)

    Indelicato, I.; La Cognata, M.; Spitaleri, C.; Burjan, V.; Cherubini, S.; Gulino, M.; Hayakawa, S.; Hons, Z.; Kroha, V.; Lamia, L.; Mazzocco, M.; Mrazek, J.; Pizzone, R. G.; Romano, S.; Strano, E.; Torresi, D.; Tumino, A.

    2017-08-01

    Fluorine abundance determination is of great importance in stellar physics to understand s-elements production and mixing processes in asymptotic giant branch (AGB) stars. Up to now, theoretical models overproduce F abundances in AGB stars with respect to the observed values, thus calling for further investigation of the reactions involving fluorine. In particular, the 19F(p, α)16O reaction is the main destruction channel of fluorine at the bottom of the convective envelope in AGB stars, an H-rich environment where it can experience temperatures high enough to determine its destruction, owing to additional mixing processes. In this paper the Trojan horse method (THM) was used to extract the 19F(p, α 0)16O S-factor in the energy range of astrophysical interest (E cm ≈ 0-1 MeV). This is the most relevant channel at the low temperatures (few 107 K) characterizing the bottom of the convective envelope, according to current knowledge. A previous indirect experiment using the THM has observed three resonances in the energy regions below E cm ≈ 450 keV. These energies correspond to typical AGB temperatures, thus implying a significant increase in the reaction rate. Statistics are scarce for performing an accurate separation between resonances, preventing one from drawing a quantitative conclusion about their total widths and spin parities. Before THM measurement, only extrapolations were available below about 500 keV, showing a non-resonant behavior that sharply contradicts the trend of the astrophysical factor at higher energies. A new experiment has been performed to verify the measured TH astrophysical factor and to perform more accurate spectroscopy of the involved resonances.

  2. Development of methodology for alternative testing strategies for the assessment of the toxicological profile of nanoparticles used in medical diagnostics. NanoTEST - EC FP7 project

    Energy Technology Data Exchange (ETDEWEB)

    Dusinska, Maria; Fjellsbo, Lise Maria; Heimstad, Eldbjorg; Harju, Mikael; Bartonova, Alena [Norwegian Institute for Air Research (Norway)], E-mail: dusinska@szu.sk; Tran, Lang [Institute of Occupational Medicine (United Kingdom); Juillerat-Jeanneret, Lucienne; Halamoda, Blanka [Centre Hospitalier Universitaire Vaudois (Switzerland); Marano, Francelyne; Boland, Sonja [University Paris Diderot Paris7 (France); Saunders, Margaret; Cartwright, Laura; Carreira, Sara; Thawley, Susan [University Hospitals Bristol NHS Foundation Trust (United Kingdom); Whelan, Maurice; Klein, Christoph [EC - Directorate General Joint Research Centre (Italy); Housiadas, Christos [National Centre for Scientific Research Demokritos (Greece); Volkovova, Katarina; Tulinska, Jana; Beno, Milan [Slovak Medical University (Slovakia)] (and others)

    2009-05-01

    Nanoparticles (NPs) have unique, potentially beneficial properties, but their possible impact on human health is still not known. The area of nanomedicine brings humans into direct contact with NPs and it is essential for both public confidence and the nanotech companies that appropriate risk assessments are undertaken in relation to health and safety. There is a pressing need to understand how engineered NPs can interact with the human body following exposure. The FP7 project NanoTEST (www.nanotest-fp7.eu) addresses these requirements in relation to the toxicological profile of NPs used in medical diagnostics.

  3. Comparison of 2015 Medicare relative value units for gender-specific procedures: Gynecologic and gynecologic-oncologic versus urologic CPT coding. Has time healed gender-worth?

    Science.gov (United States)

    Benoit, M F; Ma, J F; Upperman, B A

    2017-02-01

    In 1992, Congress implemented a relative value unit (RVU) payment system to set reimbursement for all procedures covered by Medicare. In 1997, data supported that a significant gender bias existed in reimbursement for gynecologic compared to urologic procedures. The present study was performed to compare work and total RVU's for gender specific procedures effective January 2015 and to evaluate if time has healed the gender-based RVU worth. Using the 2015 CPT codes, we compared work and total RVU's for 50 pairs of gender specific procedures. We also evaluated 2015 procedure related provider compensation. The groups were matched so that the procedures were anatomically similar. We also compared 2015 to 1997 RVU and fee schedules. Evaluation of work RVU's for the paired procedures revealed that in 36 cases (72%), male vs female procedures had a higher wRVU and tRVU. For total fee/reimbursement, 42 (84%) male based procedures were compensated at a higher rate than the paired female procedures. On average, male specific surgeries were reimbursed at an amount that was 27.67% higher for male procedures than for female-specific surgeries. Female procedure based work RVU's have increased minimally from 1997 to 2015. Time and effort have trended towards resolution of some gender-related procedure worth discrepancies but there are still significant RVU and compensation differences that should be further reviewed and modified as surgical time and effort highly correlate. Copyright © 2016. Published by Elsevier Inc.

  4. FP7-ICT-2009-4 WHERE2 D1.1:Scenarios and Parameters

    OpenAIRE

    2011-01-01

    This document species the typical scenarios dened by the WHERE2 consortium that will be used as a reference for the design and evaluation of the positioning and communication techniques to be investigated and demonstrated in this project. One scenario is characterized by an underlying wireless infrastructure deployed in a given context and a validation and test case. The retained solution consists of a heterogeneous wireless infrastructure in which a wide-range centralized system coexists and...

  5. Pattern Discovery using Fuzzy FP-growth Algorithm from Gene Expression Data

    OpenAIRE

    Sabita Barik; Debahuti Mishra; Shruti Mishra; Sandeep Ku. Satapathy; Amiya Ku. Rath; Milu Acharya

    2010-01-01

    Abstract- The goal of microarray experiments is to identify genes that are differentially transcribed with respect to different biological conditions of cell cultures and samples. Hence, method of data analysis needs to be carefully evaluated such as clustering, classification, prediction etc. In this paper, we have proposed an efficient frequent pattern based clustering to find the gene which forms frequent patterns showing similar phenotypes leading to specific symptoms for specific disease...

  6. Reliability worth applied to transmission expansion planning based on ant colony system

    Energy Technology Data Exchange (ETDEWEB)

    Leite da Silva, Armando M.; Rezende, Leandro S. [Institute of Electric Systems and Energy, Federal University of Itajuba, UNIFEI (Brazil); da Fonseca Manso, Luiz A.; de Resende, Leonidas C. [Department of Electrical Engineering, Federal University of Sao Joao del Rei, UFSJ (Brazil)

    2010-12-15

    This paper proposes a new methodology to solve transmission expansion planning (TEP) problems in power system, based on the metaheuristic ant colony optimisation (ACO). The TEP problem includes the search for the least cost solution, bearing in mind investment cost and reliability worth. Reliability worth is considered through the assessment of the interruption costs represented by the index LOLC - loss of load cost. The focus of this work is the development of a tool for the multi-stage planning of transmission systems and how reliability aspects can influence on the decision-making process. The applications of the proposed methodology are illustrated through case studies carried out using a test system and a real sub-transmission network. (author)

  7. "I'm worth more than that": trait positivity predicts increased rejection of unfair financial offers.

    Directory of Open Access Journals (Sweden)

    Barnaby D Dunn

    Full Text Available Humans react strongly to unfairness, sometimes rejecting inequitable proposals even if this sacrifices personal financial gain. Here we explored whether emotional dispositions--trait tendencies to experience positive or negative feelings--shape the rejection of unfair financial offers. Participants played an Ultimatum Game, where the division of a sum of money is proposed and the player can accept or reject this offer. Individuals high in trait positivity and low in trait negativity rejected more unfair offers. These relationships could not be explained by existing accounts which argue that rejection behaviour results from a failure to regulate negative emotions, or serves to arbitrate social relationships and identity. Instead, the relationship between dispositional affect and rejection behaviour may be underpinned by perceived self worth, with those of a positive disposition believing that they are "worth more than that" and those of a negative disposition resigning themselves to "taking the crumbs from under the table".

  8. "I'm worth more than that": trait positivity predicts increased rejection of unfair financial offers.

    Science.gov (United States)

    Dunn, Barnaby D; Makarova, Dasha; Evans, David; Clark, Luke

    2010-12-08

    Humans react strongly to unfairness, sometimes rejecting inequitable proposals even if this sacrifices personal financial gain. Here we explored whether emotional dispositions--trait tendencies to experience positive or negative feelings--shape the rejection of unfair financial offers. Participants played an Ultimatum Game, where the division of a sum of money is proposed and the player can accept or reject this offer. Individuals high in trait positivity and low in trait negativity rejected more unfair offers. These relationships could not be explained by existing accounts which argue that rejection behaviour results from a failure to regulate negative emotions, or serves to arbitrate social relationships and identity. Instead, the relationship between dispositional affect and rejection behaviour may be underpinned by perceived self worth, with those of a positive disposition believing that they are "worth more than that" and those of a negative disposition resigning themselves to "taking the crumbs from under the table".

  9. Connecting the horizontal dimension of social comparison with self-worth and self-confidence.

    Science.gov (United States)

    Locke, Kenneth D

    2005-06-01

    Multilevel modeling of undergraduates (N = 229) event-contingent records of naturalistic social comparison experiences revealed distinct correlates of the horizontal (similar-different) dimension and vertical (better-worse) dimension of comparisons. Complementing past studies showing associations between the horizontal dimension and communal dispositions and experiences, the current study showed that the horizontal dimension also is associated with agentic dispositions and experiences such as self-worth and self-confidence. For example, participants perceived more similarity when comparing with targets' desirable attributes than with targets' undesirable attributes and perceiving similarities with desirable target attributes (and dissimilarities with undesirable target attributes) enhanced their self-confidence. Participants higher in self-worth (high in self-esteem and low in depression) were more discriminating in their experiences of similarity and connection; specifically, they reported more similarity and connection when targets' attributes were desirable but less connection the more targets' attributes were inferior to their own.

  10. Dual worth trade-off method and its application for solving multiple criteria decision making problems

    Institute of Scientific and Technical Information of China (English)

    Feng Junwen

    2006-01-01

    To overcome the limitations of the traditional surrogate worth trade-off (SWT) method and solve the multiple criteria decision making problem more efficiently and interactively, a new method labeled dual worth trade-off (DWT) method is proposed. The DWT method dynamically uses the duality theory related to the multiple criteria decision making problem and analytic hierarchy process technique to obtain the decision maker's solution preference information and finally find the satisfactory compromise solution of the decision maker. Through the interactive process between the analyst and the decision maker, trade-off information is solicited and treated properly, the representative subset of efficient solutions and the satisfactory solution to the problem are found. The implementation procedure for the DWT method is presented. The effectiveness and applicability of the DWT method are shown by a practical case study in the field of production scheduling.

  11. Peter Singer and 'lives not worth living'--comments on a flawed argument from analogy.

    Science.gov (United States)

    Sundström, P

    1995-02-01

    The Australian bioethicist Peter Singer has presented an intriguing argument for the opinion that it is quite proper (morally) to deem the lives of certain individuals not worth living and so to kill them. The argument is based on the alleged analogy between the ordinary clinical judgement that a life with a broken leg is worse than a life with an intact leg (other things being equal), and that the broken leg therefore ought to be mended, on the one hand, and the judgement that the lives of some individuals, for example, severely disabled infants, are not worth living and therefore ought to be terminated, on the other. In the present article it is argued that Singer's argument is flawed, intellectually and/or ethically.

  12. The pursuit of self-esteem: contingencies of self-worth and self-regulation.

    Science.gov (United States)

    Crocker, Jennifer; Brook, Amara T; Niiya, Yu; Villacorta, Mark

    2006-12-01

    Successful self-regulation is defined as the willingness to exert effort toward one's most important goals, while taking setbacks and failures as opportunities to learn, identify weaknesses and address them, and develop new strategies toward achieving those goals. Contingencies of self-worth can facilitate self-regulation because people are highly motivated to succeed and avoid failure in domains of contingency. However, because boosts in self-esteem are pleasurable and drops in self-esteem are painful, protection, maintenance, and enhancement of self-esteem can become the overriding goal. Several pitfalls for self-regulation can result, especially when tasks are difficult and failure is likely. In this article, we describe a program of research examining these self-regulation pitfalls associated with contingent self-worth and suggest that learning orientations, particularly the willingness to embrace failure for the learning it affords, foster successful self-regulation even in people with highly contingent self-esteem.

  13. The changing influences of self-worth and peer deviance on drinking problems in urban American Indian adolescents.

    Science.gov (United States)

    Radin, Sandra M; Neighbors, Clayton; Walker, Patricia Silk; Walker, R Dale; Marlatt, G Alan; Larimer, Mary

    2006-06-01

    This study explored the changing relations among self-worth, peer deviance, and alcohol-related problems in a sample of 224 urban-dwelling, American Indian adolescents. Data were collected annually at 7 time points to test a proposed mediational model. As expected, peer deviance mediated the relation between low self-worth and alcohol-related problems in younger adolescents; however, this relation did not hold as participants became older. In older adolescents, low self-worth and peer deviance directly and independently contributed to alcohol problems. Possible explanations for and implications of these findings are discussed in terms of developmental changes during adolescence.

  14. Prospective Relations among Low-Income African American Adolescents’ Maternal Attachment Security, Self-Worth, and Risk Behaviors

    Science.gov (United States)

    Lockhart, Ginger; Phillips, Samantha; Bolland, Anneliese; Delgado, Melissa; Tietjen, Juliet; Bolland, John

    2017-01-01

    This study examined prospective mediating relations among mother-adolescent attachment security, self-worth, and risk behaviors, including substance use and violence, across ages 13–17 in a sample of 901 low-income African American adolescents. Path analyses revealed that self-worth was a significant mediator between attachment security and risk behaviors, such that earlier attachment security predicted self-worth 1 year later, which in turn, predicted substance use, weapon carrying, and fighting in the 3rd year. Implications for the role of the secure base concept within the context of urban poverty are discussed. PMID:28174548

  15. The Democratic Worth of Celebrity Politics in an Era of Late Modernity

    OpenAIRE

    Wheeler, Mark

    2012-01-01

    Keywords:\\ud \\ud celebrity politicians;\\ud late modernity;\\ud Barack Obama;\\ud political aesthetics\\ud \\ud In a seminal article published in 2004, John Street argued that celebrity politics has provided a greater expression for the enhancement of democratic behaviour. Consequently, this analysis builds on Street's thesis to consider the worth of celebrity politics in an era of late modernity. To this end, it employs Henrik Bang's and John Keane's constructs of Everyday Makers and Monitory Dem...

  16. Social Support and Neighborhood Stressors Among African American Youth: Networks and Relations to Self-Worth

    OpenAIRE

    McMahon, Susan D.; Felix, Erika D.; Nagarajan, Thara

    2010-01-01

    Although neighborhood stressors have a negative impact on youth, and social support can play a protective role, it is unclear what types and sources of social support may contribute to positive outcomes among at-risk youth. We examined the influences of neighborhood disadvantage and social support on global self-worth among low-income, urban African American youth, both concurrently and longitudinally. We examined social support from both a structural and functional perspective, and tested th...

  17. Towards a comparable carbon footprint for local initiatives: The FP7 project TESS

    Science.gov (United States)

    Reusser, Dominik E.; Kropp, Jürgen P.

    2014-05-01

    TESS (Towards European Societal Sustainability -- www.tess-transition.eu) is a three-year, European-wide research project. It aims to reach an understanding of the potential for community-led initiatives to help deliver a truly sustainable, low-carbon future. Transitions to low-carbon societies take place at multiple and complementary scales. Transition processes are highly dependent on the innovative potential of community-based initiatives and their articulation with appropriate institutional architecture. Community-based initiatives are potentially more adaptable and less constrained by current structural circumstances than top-down policies and can give impetus to large-scale and technology driven changes. TESS will provide an understanding on the upscaling possibilities of such high-potential community-based initiatives by addressing two main questions: What is the impact of community-based initiatives in terms of carbon reduction potential and economic effect? What institutional structures (values, policies and mechanisms) support these initiatives in persisting beyond the initial phase and moving into an acceleration phase, spreading desired impacts? Answers will be provided through (1) a novel measuring, reporting and verification (MRV) framework for benchmarking community-based initiatives. This will enable quantifiable, comparable and standardised evaluation, and (2) the identification of success factors for the emergence, persistence and diffusion of promising initiatives, including online initiatives. We will identify these initiatives through case studies across regions and sectors and produce a systemic understanding of their impact on societal transitions towards sustainability. Our research will be integrated and transdisciplinary, with the unique opportunity to bring together social and natural scientists to foster a transition towards European societal sustainability. Our work will feed into and extend the Climate Adapt database to facilitate

  18. An Efficient Data-worth Analysis Framework via Probabilistic Collocation Method Based Ensemble Kalman Filter

    Science.gov (United States)

    Xue, L.; Dai, C.; Zhang, D.; Guadagnini, A.

    2015-12-01

    It is critical to predict contaminant plume in an aquifer under uncertainty, which can help assess environmental risk and design rational management strategies. An accurate prediction of contaminant plume requires the collection of data to help characterize the system. Due to the limitation of financial resources, ones should estimate the expectative value of data collected from each optional monitoring scheme before carried out. Data-worth analysis is believed to be an effective approach to identify the value of the data in some problems, which quantifies the uncertainty reduction assuming that the plausible data has been collected. However, it is difficult to apply the data-worth analysis to a dynamic simulation of contaminant transportation model owning to its requirement of large number of inverse-modeling. In this study, a novel efficient data-worth analysis framework is proposed by developing the Probabilistic Collocation Method based Ensemble Kalman Filter (PCKF). The PCKF constructs polynomial chaos expansion surrogate model to replace the original complex numerical model. Consequently, the inverse modeling can perform on the proxy rather than the original model. An illustrative example, considering the dynamic change of the contaminant concentration, is employed to demonstrate the proposed approach. The Results reveal that schemes with different sampling frequencies, monitoring networks location, prior data content will have significant impact on the uncertainty reduction of the estimation of contaminant plume. Our proposition is validated to provide the reasonable value of data from various schemes.

  19. Polychlorinated Biphenyls in suspended-sediment samples from outfalls to Meandering Road Creek at Air Force Plant 4, Fort Worth, Texas, 2003-08

    Science.gov (United States)

    Braun, Christopher L.; Wilson, Jennifer T.

    2010-01-01

    Meandering Road Creek is an intermittent stream and tributary to Lake Worth, a reservoir on the West Fork Trinity River on the western edge of Fort Worth, Texas. U.S. Air Force Plant 4 (AFP4) is on the eastern shore of Woods Inlet, an arm of Lake Worth. Meandering Road Creek gains inflow from several stormwater outfalls as it flows across AFP4. Several studies have characterized polychlorinated biphenyls (PCBs) in the water and sediments of Lake Worth and Meandering Road Creek; sources of PCBs are believed to originate primarily from AFP4. Two previous U.S. Geological Survey (USGS) reports documented elevated PCB concentrations in surficial sediment samples from Woods Inlet relative to concentrations in surficial sediment samples from other parts of Lake Worth. The second of these two previous reports also identified some of the sources of PCBs to Lake Worth. These reports were followed by a third USGS report that documented the extent of PCB contamination in Meandering Road Creek and Woods Inlet and identified runoff from outfalls 4 and 5 at AFP4 as prominent sources of these PCBs. This report describes the results of a fourth study by the USGS, in cooperation with the Lockheed Martin Corporation, to investigate PCBs in suspended-sediment samples in storm runoff from outfalls 4 and 5 at AFP4 following the implementation of engineering controls designed to potentially alleviate PCB contamination in the drainage areas of these outfalls. Suspended-sediment samples collected from outfalls 4 and 5 during storms on March 2 and November 10, 2008, were analyzed for selected PCBs. Sums of concentrations of 18 reported PCB congeners (Sigma PCBc) in suspended-sediment samples collected before and after implementation of engineering controls are compared. At both outfalls, the Sigma PCBc before engineering controls was higher than the Sigma PCBc after engineering controls. The Sigma PCBc in suspended-sediment samples collected at AFP4 before and after implementation of

  20. Evaluation of hemoglobin A1c measurement from filter paper using high-performance liquid chromatography and immunoturbidimetric assay.

    Science.gov (United States)

    Wu, Yonghua; Yang, Xu; Wang, Haining; Li, Zhenrong; Wang, Tiancheng

    2017-04-01

    Glycated hemoglobin (HbA1c) measurement from whole blood (WB) samples is inconvenient for epidemic surveillance and self-monitoring of glycemic level. We evaluated HbA1c measurement from WB blotted on filter paper (FP), which can be easily transported to central laboratories, with high-performance liquid chromatography (HPLC) and immunoturbidimetric assay (ITA). WB was applied to Whatman filter paper. By using HPLC and WB samples as reference methods, these FP samples were evaluated on HPLC and ITA. Inter- and intra-assay variation, WB vs. FP agreement and sample stability at 20-25 °C and -70 °C were assessed by statistical analysis. Results showed that the coefficient of variation (CV, %) of FP samples for HPLC and ITA were 0.44-1.02% and 1.47-2.72%, respectively (intra-assay); 2.13-3.56% and 3.21-4.82%, respectively (inter-assay). The correlation of WB HPLC with FP analyzed using HPLC and ITA are both significant (p < 0.001). Sample stability showed that FP method up to 5 days at 20-25 °C and 5 weeks at -70 °C is accurate and reproducible. In conclusion, FP samples analyzed by HPLC and ITA can both provide an alternative to WB for HbA1c measurement, supporting the use of FP method in epidemic surveillance and healthcare units.

  1. Women's worth.

    Science.gov (United States)

    Bloch, N

    1992-01-01

    Jill Conway is a feminist historian, writer, teacher, and now-emerita 1st woman president of Smith College. She claims that women today still suffer from a great deal of oppression. Women around the world are currently in a disadvantage position. In 7 countries women do not have the right to vote. In the US less that .5% of top executives are women. The wage gap in the US between 1939 and 1989 has only shrunk $.10, from $.58-$.68. Conway points out that we are all constrained by our social mores, generational attitudes, political events, and economic circumstances. Few people are able to overcome these things in the way that they live their lives. Conway questions the validity of history written from a male dominated point of view. Around the world the value of women's work is almost always lower than that of men. India is just 1 example, there 75% of women are illiterate and 1/2 the population lives in poverty based on a caste system. Female literacy tripled in the 1st 30 years of independence and by 1981 it had reached 25%. The literacy gap is actually growing in India Today with 44% of girls aged 6 to 11, who are eligible to attend school, not doing so. Rural poverty keeps them at home because their domestic work is more valuable than their education. Other cultural tradition compound the problem: arranged marriages often result in motherhood for 14 year old girls. This is done for many reasons, 1 of which is crop failure insurance. When 2 families are combined through marriage, their total land share grows and they are thus more likely to have enough to eat. Education is just 1 necessary step. Developed nations must realize the realities that exist in the countries they provide aid for. In Africa for example, 70% of continent's food is produced by women. Yet the aid programs of the past have only been designed to offer assistant to men and create jobs for men.

  2. Does self-threat promote social connection? The role of self-esteem and contingencies of self-worth.

    Science.gov (United States)

    Park, Lora E; Maner, Jon K

    2009-01-01

    Six studies examined the social motivations of people with high self-esteem (HSE) and low self-esteem (LSE) following a threat to a domain of contingent self-worth. Whether people desired social contact following self-threat depended on an interaction between an individual's trait self-esteem and contingencies of self-worth. HSE participants who strongly based self-worth on appearance sought to connect with close others following a threat to their physical attractiveness. LSE participants who staked self-worth on appearance wanted to avoid social contact and, instead, preferred a less interpersonally risky way of coping with self-threat (wanting to enhance their physical attractiveness). Implications for theories of self-esteem, motivation, and interpersonal processes are discussed.

  3. Implementation of the European multicentre database of healthy controls for [(123)I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

    DEFF Research Database (Denmark)

    Albert, Nathalie L; Unterrainer, Marcus; Diemling, Markus

    2016-01-01

    PURPOSE: Even though [(123)I]FP-CIT SPECT provides high accuracy in detecting nigrostriatal cell loss in neurodegenerative parkinsonian syndromes (PS), some patients with an inconclusive diagnosis remain. We investigated whether the diagnostic accuracy in patients with clinically uncertain PS...

  4. Repeated administration of D-amphetamine induces loss of [{sup 123}I]FP-CIT binding to striatal dopamine transporters in rat brain: a validation study

    Energy Technology Data Exchange (ETDEWEB)

    Booij, Jan [Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam (Netherlands)]. E-mail: j.booij@amc.uva.nl; Bruin, Kora de [Department of Nuclear Medicine, Academic Medical Center, 1105 AZ Amsterdam (Netherlands); Gunning, W. Boudewijn [Department of Neurology, Epilepsy Centre Kempenhaeghe, 5590 AB Heeze (Netherlands)

    2006-04-15

    In recent years, several PET and SPECT studies have shown loss of striatal dopamine transporter (DAT) binding in amphetamine (AMPH) users. However, the use of DAT SPECT tracers to detect AMPH-induced changes in DAT binding has not been validated. We therefore examined if repeated administration of D-AMPH or methamphetamine (METH) may induce loss of binding to striatal DATs in rats by using an experimental biodistribution study design and a SPECT tracer for the DAT ([{sup 123}I]FP-CIT). Methods: Groups of male rats (n=10 per group) were treated with D-AMPH (10 mg/kg body weight), METH (10 mg/kg body weight), or saline, twice a day for 5 consecutive days. Five days later, [{sup 123}I]FP-CIT was injected intravenously, and 2 h later, the rats were sacrificed and radioactivity was assayed. Results: In D-AMPH but not METH-treated rats, striatal [{sup 123}I]FP-CIT uptake was significantly lower (approximately 17%) than in the control group. Conclusion: These data show that [{sup 123}I]FP-CIT can be used to detect AMPH-induced changes in DAT binding and may validate the use of DAT radiotracers to study AMPH-induced changes in striatal DAT binding in vivo.

  5. ENVIRONMENTAL TECHNOLOGY VERIFICATION, TEST REPORT OF CONTROL OF BIOAEROSOLS IN HVAC SYSTEMS, FILTRATION GROUP, AEROSTAR FP-98 MINIPLEAT V-BLANK FILTER

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of the AeroStar FP-98 Minipleat V-Bank Filter air filter for dust and bioaerosol filtration manufactured by Filtration Group. The pressure drop across the filter was 137 Pa clean and 348 Pa ...

  6. Fuzzy-PI-based centralised control of semi-isolated FP-SEPIC/ZETA BDC in a PV/battery hybrid system

    Science.gov (United States)

    Mahendran, Venmathi; Ramabadran, Ramaprabha

    2016-11-01

    Multiport converters with centralised controller have been most commonly used in stand-alone photovoltaic (PV)/battery hybrid system to supply the load smoothly without any disturbances. This study presents the performance analysis of four-port SEPIC/ZETA bidirectional converter (FP-SEPIC/ZETA BDC) using various types of centralised control schemes like Fuzzy tuned proportional integral controller (Fuzzy-PI), fuzzy logic controller (FLC) and conventional proportional integral (PI) controller. The proposed FP-SEPIC/ZETA BDC with various control strategy is derived for simultaneous power management of a PV source using distributed maximum power point tracking (DMPPT) algorithm, a rechargeable battery, and a load by means of centralised controller. The steady state and the dynamic response of the FP-SEPIC/ZETA BDC are analysed using three different types of controllers under line and load regulation. The Fuzzy-PI-based control scheme improves the dynamic response of the system when compared with the FLC and the conventional PI controller. The power balance between the ports is achieved by pseudorandom carrier modulation scheme. The response of the FP-SEPIC/ZETA BDC is also validated experimentally using hardware prototype model of 500 W system. The effectiveness of the control strategy is validated using simulation and experimental results.

  7. No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using (123I)FP-CIT (DaTSCAN) and SPECT

    DEFF Research Database (Denmark)

    Thomsen, G; Knudsen, Gitte Moos; Jensen, PS;

    2013-01-01

    tobacco smoking: (1) non-smokers (n = 64), (2) ex-smokers (n = 39) and (3) active smokers (n = 26). For imaging of the DAT availability, we used [123I]FP-CIT (DaTSCAN) and single photon emission computed tomography (SPECT). Data were collected in collaboration between 13 SPECT centres located in 10...

  8. Potential environmental benefits of improving recycling of polyolefines – LCA of Magnetic density separation (MDS) developed in the EU FP7 funded project W2Plastic

    DEFF Research Database (Denmark)

    Olsen, Stig Irving; Bonou, Alexandra

    2012-01-01

    The core of the EU FP7 funded project W2Plastic is development of a magnetic density separation (MDS) of polyolefines in order to improve the sorting efficiency of these polymer types in different waste fractions. As part of the project a life cycle assessment is performed in order to firstly...

  9. Degree of Contamination and Sources of Polychlorinated Biphenyls in Meandering Road Creek and Woods Inlet of Lake Worth, Fort Worth, Texas, 2004 and 2006-07

    Science.gov (United States)

    Braun, Christopher L.; Wilson, Jennifer T.; Van Metre, Peter C.

    2008-01-01

    Lake Worth is a reservoir on the West Fork Trinity River on the western edge of Fort Worth, Texas. Air Force Plant 4 (AFP4) is on the eastern shore of Woods Inlet, an arm of Lake Worth that extends south from the main body of the lake. Two previous reports documented ele-vated polychlorinated biphenyl (PCB) concentrations in surficial sediment in Woods Inlet relative to those in surficial sediment in other parts of Lake Worth. This report presents the results of another USGS study, done in cooperation with the U.S. Air Force, to indicate the degree of PCB contamination of Meandering Road Creek and Woods Inlet and to identify possible sources of PCBs in Meandering Road Creek and Woods Inlet on the basis of suspended, streambed, and lake-bottom sediment samples collected there in 2004 and 2006-07. About 40 to 80 percent of total PCB concentrations (depending on how total PCB concentration is computed) in suspended sediment exceed the threshold effect concentration, a concentration below which adverse effects to benthic biota rarely occur. About 20 percent of total PCB concentrations (computed as sum of three Aroclors) in suspended sediment exceed the probable effect concentration, a concentration above which adverse effects to benthic biota are expected to occur frequently. About 20 to 30 percent of total PCB concentrations in streambed sediment exceed the threshold effect concentration; and about 6 to 20 percent of total PCB concentrations in lake-bottom (Woods Inlet) sediment exceed the threshold effect concentration. No streambed or lake-bottom sediment concentrations exceed the probable effect concentration. The sources of PCBs to Meandering Road Creek and Woods Inlet were investigated by comparing the relative distributions of PCB congeners of suspended sediment to those of streambed and lake-bottom sediment. The sources of PCBs were identified using graphical analysis of normalized concentrations (congener ratios) of 11 congeners. For graphical analysis, the

  10. Comparison of FP-7 and S-2 Ahmed glaucoma valve implantation in refractory glaucoma patients for short-term follow-up

    Institute of Scientific and Technical Information of China (English)

    BAI Yu-jing; LI Yi-qing; CHAI Fang; YANG Xue-jiao; ZHANG Yi-chong; WEI Yan-tao; HUANG Jing-jing; GE Jian; ZHUO Ye-hong

    2011-01-01

    Background Ahmed glaucoma valves (AGV) has been used for decades, but there is no detailed report about the efficacy of AGV in Chinese glaucoma patients. This study aimed to compare the intraocular pressure (IOP) lowering efficacy and side effects of S-2 polypropylene and PF-7 silicone AGV implantation in Chinese refractory glaucoma patients.Methods Patients were divided into S-2 model AGV group and FP-7 model AGV group. The complete and qualified surgical success rate, change of IOP, number of anti-glaucoma medications used and postoperative complications were recorded and analyzed.Results Average follow-up time was comparable between two groups. IOP was reduced from (37.9±12.7) mmHg preoperatively to (17.3±5.3) mmHg at the last follow-up in S-2 group and reduced from (39.9±14.4) mmHg to (17.7±4.9)mmHg in FP-7 group. Anti-glaucoma medications were reduced from 3.8±0.2 to 1.5±0.2 in S-2 group, and 3.5±0.2 to 0.7±0.2 in FP-7 groups. The cumulative success rates were comparable in two groups, which were 61.2% and 72.1% in S-2 group and FP-7 group respectively. When IOP reduction criteria was used, complete success rates were 30.6% and 51.2% for S-2 and FP-7 groups, and qualified success rates were 86.1% and 92.7% separately. In both groups, the major complication was hypotony, and the previous trabeculectomy of patients was the major risk factor for surgery failure.Conclusions In this short-term retrospective study, S-2 AGV is showed at least as effective as FP-7 AGV in IOP reduction, but associated with higher rate of complications. Previous trabeculectomy is a principle risk factor for AGV implantation failure. These clinical outcomes are important for converting use of the FP-7 silicon AGV in Chinese refractory glaucoma patients.

  11. The direct and indirect role of self esteem and procrastination in the relation to fear of failure and self worth

    OpenAIRE

    Murat Balkıs; Erdinç Duru

    2012-01-01

    The aim of this study was to investigate the direct and indirect role of self esteem and procrastination in the relation between fear of failure and self worth.  The participants were 279 students who study different major fields at the Faculty of Education in Pamukkale University. Age range varied from 19 to 34. In this study, Tuckman Procrastination Inventory, Rosenberg Self Esteem Inventory, Activate and Success Based Self Worth Scale, Concern over Mistakes Scale and Personal Information S...

  12. Applications and Compatibility Laws of Associated Prescriptions of Siwu Tang Based on FP-Growth Algorithm%基于FP-Growth算法的四物汤类方配伍规律及应用研究

    Institute of Scientific and Technical Information of China (English)

    陶静; 范欣生; 张欢; 段金廒; 王崇峻; 刘正

    2010-01-01

    目的:运用数据挖掘方法,挖掘单味药、药对之间的关联关系,分析类方和药对内部的组成关系,探讨四物汤的配伍规律.方法:收集四物汤类方3487首,针对四物汤药物配伍和药对特征,对单味药、药对之间的关联关系,分别采用频繁模式、FP-Growth算法.结果:获得置信度>0.15的四物汤配伍常用药有甘草、人参、肉桂、茯苓,常用药对有当归-甘草、川芎-甘草、地黄-甘草、芍药-甘草、人参-甘草、茯苓-甘草.结论:四物汤常用配伍主要有补益药、行气药、温里药、清热药、活血化瘀药,并由此形成常用药对,在妇科疾病的治疗中得到了广泛的应用.

  13. Combined visual and semi-quantitative assessment of (123)I-FP-CIT SPECT for the diagnosis of dopaminergic neurodegenerative diseases.

    Science.gov (United States)

    Ueda, Jun; Yoshimura, Hajime; Shimizu, Keiji; Hino, Megumu; Kohara, Nobuo

    2017-07-01

    Visual and semi-quantitative assessments of (123)I-FP-CIT single-photon emission computed tomography (SPECT) are useful for the diagnosis of dopaminergic neurodegenerative diseases (dNDD), including Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration. However, the diagnostic value of combined visual and semi-quantitative assessment in dNDD remains unclear. Among 239 consecutive patients with a newly diagnosed possible parkinsonian syndrome who underwent (123)I-FP-CIT SPECT in our medical center, 114 patients with a disease duration less than 7 years were diagnosed as dNDD with the established criteria or as non-dNDD according to clinical judgment. We retrospectively examined their clinical characteristics and visual and semi-quantitative assessments of (123)I-FP-CIT SPECT. The striatal binding ratio (SBR) was used as a semi-quantitative measure of (123)I-FP-CIT SPECT. We calculated the sensitivity and specificity of visual assessment alone, semi-quantitative assessment alone, and combined visual and semi-quantitative assessment for the diagnosis of dNDD. SBR was correlated with visual assessment. Some dNDD patients with a normal visual assessment had an abnormal SBR, and vice versa. There was no statistically significant difference between sensitivity of the diagnosis with visual assessment alone and semi-quantitative assessment alone (91.2 vs. 86.8%, respectively, p = 0.29). Combined visual and semi-quantitative assessment demonstrated superior sensitivity (96.7%) to visual assessment (p = 0.03) or semi-quantitative assessment (p = 0.003) alone with equal specificity. Visual and semi-quantitative assessments of (123)I-FP-CIT SPECT are helpful for the diagnosis of dNDD, and combined visual and semi-quantitative assessment shows superior sensitivity with equal specificity.

  14. Prostaglandin (PG) FP and EP1 receptors mediate PGF2alpha and PGE2 regulation of interleukin-1beta expression in Leydig cell progenitors.

    Science.gov (United States)

    Walch, Laurence; Clavarino, Emanuela; Morris, Patricia L

    2003-04-01

    Prostaglandins (PG) mediate IL-1beta regulation of several interleukin mRNAs in progenitor Leydig cells. PGE(2) and PGF(2alpha) potently reverse indomethacin (INDO; a cyclooxygenase inhibitor) inhibition of IL-1beta autoinduction. IL-1beta increases PGE(2) and PGF(2alpha) production. To determine the PG receptors involved in this regulation, this study established by RT-PCR and Western analyses which specific receptors for PGE(2) (EP receptors) and PGF(2alpha) (FP receptors) are expressed in progenitors. Pharmacological characterization of receptors involved in PGE(2) and PGF(2alpha) regulation of IL-1beta mRNA levels was ascertained using real-time PCR analyses. FP, EP(1), EP(2), and EP(4) receptor mRNAs and proteins, and an EP(3) receptor subtype were detected. IL-1beta treatment (24-h) significantly decreased EP(1) receptor levels; INDO abrogated this down-regulation. FP, EP(2), and EP(4) receptor levels increased after IL-1beta and IL-1beta + INDO. A selective FP agonist, cloprostenol (0.1 micro M), and PGF(2alpha) (10 micro M) had similar effects on IL-1beta mRNA levels in progenitors treated with IL-1beta + INDO. None of the EP(2)/EP(4) agonists [butaprost, misoprostol, or 11-deoxy PGE(1) (10 micro M)] affected IL-1beta mRNA levels. In contrast, EP(1)/EP(3) agonists (17-phenyl trinor PGE(2) and sulprostone) increased IL-1beta mRNAs in a dose-dependent manner. EP(1) receptor subtype-selective antagonist, SC-51322, blocked IL-1beta-induced and [IL-1beta + INDO + 17-phenyl trinor PGE(2)]-induced increases in IL-1beta mRNAs. Taken together, our data demonstrate that FP and EP(1) receptors mediate PGF(2alpha) and PGE(2) induction of progenitor IL-1beta expression.

  15. The implementation of the Open Access paradigm to the EC-FP7 MED-SUV (Mediterranean Supersite Volcanoes) project

    Science.gov (United States)

    Puglisi, Giuseppe; Brito, Fabrice; Caumont, Hervé; D'Auria, Luca; Fernandez, José; Mazzetti, Paolo; Mathieu, Pierre Philippe; Nativi, Stefano; Papeschi, Fabrizio; Pepe, Antonio; Reitano, Danilo; Sangianantoni, Agata; Scarpato, Giovanni; Spampinato, Letizia

    2016-04-01

    The overall goal of the EC-FP7 Mediterranean Supersite Volcanoes (MED-SUV) project is to apply the rationale of the Supersites GEO initiative to Campi Flegrei/Vesuvius and Mt. Etna to reduce the volcanic risk, by improving the understanding of the underlying geophysical processes, through the integration and sharing of the in-situ and Earth Observation (EO) data sets and the implementation of new instruments and monitoring systems. The project involves 24 EU and no-EU partners, including research and academic institutions, space agencies and SMEs. In this framework, the application of the Open Access paradigm has offered the opportunity to study and apply practical solutions concerning the data management (i.e. data polices, foreground exploitation and sustainability), intellectual property rights (i.e., ownership, licences, agreements) and technical issues (i.e., design and implementation of an interoperability e-infrastructure, access systems, etc.). This contribution presents pro and cons encountered in the project, as well as the main outcomes of the implementation of the Open Access to the Italian Supersites. This experience will be exploited in the building of international research infrastructures, such as EPOS, and the outcomes of the project will contribute to foster the Open Access to the research data in a wide context, as the GEO-GEOSS framework.

  16. Study of proton resonances in 18Ne via resonant elastic scattering of 17F+p and its astrophysical implication

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The proton resonant properties in 18Ne, which determine the reaction rate of the key stellar 14O(α,p)17F reaction, have been studied by using a technique of proton resonant elastic scattering of 17F+p. A 4.22 MeV/nucleon 17F radioactive ion (RI) beam was produced via a projectile-fragmentation reaction, and separated by a Radioactive Ion Beam Line in Lanzhou (RIBLL). By bombarding a thick (CH2)n target, the energy spectra of the recoiled protons were measured by two ΔE-E silicon telescopes at the center-of-mass scattering angles of θc.m.≈175°±5°, θc.m.≈152°±8°, respectively. Several proton resonances in 18Ne were ob served clearly. A further R-matrix analysis of the experimental data is under way to determine the resonant parameters. The present work reports the preliminary results briefly.

  17. The FP420 R&D Project: Higgs and New Physics with forward protons at the LHC

    CERN Document Server

    Albrow, M.G.; Arneodo, Michele; Atoian, G.; Barlow, R.; Beaumont, W.; Bonnet, L.; Brandt, A.; Bussey, P.; Buttar, C.; Butterworth, J.M.; Carter, M.; Cox, B.E.; Dattola, D.; Da Via, C.; de Favereau, J.; D'Enterria, David; De Remigis, P.; De Roeck, Albert; De Wolf, Eddi A.; Duarte, P.; Ellis, John R.; Florins, B.; Forshaw, J.R.; Freestone, J.; Goulianos, Konstantin A.; Gronberg, J.; Grothe, M.; Gunion, J.F.; Hasi, J.; Heinemeyer, S.; Hollar, Jonathan J.; Houston, S.; Issakov, V.; Jones, Roger M.; Kelly, M.; Kenney, C.; Khoze, V.A.; Kolya, S.; Konstantinidis, N.; Kowalski, H.; Lanni, F.; Larsen, H.E.; Liu, S.L.; Lyapine, A.; Loebinger, Frederick K.; Marshall, R.; Martin, A.D.; Monk, James William; Nasteva, Irina; Nemegeer, P.; Obertino, M.M.; Orava, R.; O'Shea, V.; Pal, A.; Parker, S.; Pater, J.; Perrot, A.L.; Pierzchala, T.; Pilkington, A.D.; Pinfold, James L.; Piotrzkowski, Krzysztof; Plano, W.; Poblaguev, A.; Popov, V.; Potter, K.M.; Radeka, V.; Rescia, S.; Roncarolo, F.; Rostovtsev, A.; Rouby, X.; Ruspa, M.; Ryskin, M.G.; Santoro, A.; Schul, N.; Sellers, G.; Solano, A.; Spivey, S.; Stirling, W.J.; Swoboda, D.; Tasevsky, M.; Thompson, R.; Tsang, T.; Van Mechelen, P.; Vilela Pereira, A.; Watts, S.J.; Warren, M.R.M.; Weiglein, G.; Wengler, T.; White, Sebastian N.; Winter, B.; Yao, Y.; Zaborov, D.; Zampieri, A.; Zeller, M.; Zhokin, A.

    2009-01-01

    We present the FP420 R&D project, which has been studying the key aspects of the development and installation of a silicon tracker and fast-timing detectors in the LHC tunnel at 420 m from the interaction points of the ATLAS and CMS experiments. These detectors would measure precisely very forward protons in conjunction with the corresponding central detectors as a means to study Standard Model (SM) physics, and to search for and characterise New Physics signals. This report includes a detailed description of the physics case for the detector and, in particular, for the measurement of Central Exclusive Production, pp --> p + phi + p, in which the outgoing protons remain intact and the central system phi may be a single particle such as a SM or MSSM Higgs boson. Other physics topics discussed are gamma-gamma and gamma-p interactions, and diffractive processes. The report includes a detailed study of the trigger strategy, acceptance, reconstruction efficiencies, and expected yields for a particular p p --> ...

  18. Correction of PF in systems with presence of harmonics; Correccion de FP en sistemas con presencia de armonicos

    Energy Technology Data Exchange (ETDEWEB)

    IMELHIA

    2005-07-01

    This document sets an example of a typical industrial plant and everything that this implies such as: an equivalent circuit and the form in which it acts as a source of harmonic currents, the initial problem: correction of the PF, the line current of this device, the current waveform (fundamental, fundamental plus fifth harmonica, h1 + h5 + h7, h1 {yields} h13 or h1 {yields} h25), the representation of harmonics, the Fourier series, the total distortion of the harmonics (THD), the classification of the harmonics, the capacitors, the reactance, the tuned filters h5 and h7, the high tension contaminated network, the extension of the network in LT, the intensities and the reactors banks. [Spanish] Este documento nos pone un ejemplo de una planta industrial tipica y todo lo que esta implica como: un circuito equivalente y la forma en que actua como una fuente de corrientes armonicas, el problema inicial: correccion FP, la corriente de linea de este dispositivo, la forma de onda en corriente (fundamental, fundamental mas quinta armonica, h1 + h5 + h7, h1 ? h13 o h1 ? h25), la representacion de armonicas, las series de Fourier, la distorsion total de las armonicas (THD), la clasificacion de las armonicas, los capacitores, la reactancia, los filtros sintonizados h5 y h7, la red de alta tension contaminada, la extension de red en BT, las intensidades y los bancos reactores.

  19. EUTEMPE-RX, an EC supported FP7 project for the training and education of medical physics experts in radiology.

    Science.gov (United States)

    Bosmans, H; Bliznakova, K; Padovani, R; Christofides, S; Van Peteghem, N; Tsapaki, V; Caruana, C J; Vassileva, J

    2015-07-01

    The core activity of the medical physics expert (MPE) is to ensure optimal use of ionising radiation in healthcare. It is essential that these healthcare professionals are trained to the highest level, defined as European Qualifications Framework for Lifelong Learning (EQF) level 8 by the European Commission's Radiation Protection Report 174 'Guidelines on the MPE'. The main objective of the EUTEMPE-RX project is to provide a model training scheme that allows the medical physicist in diagnostic and interventional radiology (D&IR) to reach this high level. A European network of partners was brought together in this FP7 EC project to ensure sufficient expertise in all aspects of the subject and to create a harmonised course programme. Targeted participants are medical physicists in D&IR in hospitals, engineers and scientists in medical device industries and officers working in regulatory authorities. Twelve course modules will be developed at EQF level 8, with radiation safety and diagnostic effectiveness being prevalent subjects. The modules will combine online with face-to-face teaching using a blended learning approach.

  20. Sustainable introduction of GM crops into european agriculture: a summary report of the FP6 SIGMEA research project*

    Directory of Open Access Journals (Sweden)

    Messéan Antoine

    2009-01-01

    Full Text Available In 2003, the European Commission established the principle of coexistence which refers to “the ability of farmers to make a practical choice between conventional, organic and GM-crop production, in compliance with the legal obligations for labelling and/or purity standards” and laid down guidelines defining the context of this coexistence1. In order to determine what is needed for the sustainable introduction of GM crops in Europe, the cross-disciplinary SIGMEA Research Project was set up to create a science-based framework to inform decision-makers. SIGMEA has (i collated and analysed European data on gene flow and the environmental impacts of the major crop species which are likely to be transgenic in the future (maize, rapeseed, sugar beet, rice, and wheat, (ii designed predictive models of gene flow at the landscape level, (iii analysed the technical feasibility and economic impacts of coexistence in the principal farming regions of Europe, (iv developed novel GMO detection methods, (v addressed legal issues related to coexistence, and (vi proposed public and farm scale decisionmaking tools, as well as guidelines regarding management and governance. This publishable version of the final activity report of the FP6 SIGMEA research project, covers the fourteen major issues under investigation.

  1. Spectral properties of actinide materials: Charge density self-consistent LDA+Hubbard I method in FP-LAPW basis

    Energy Technology Data Exchange (ETDEWEB)

    Kolorenc, Jindrich [Institute of Physics ASCR, Prague (Czech Republic); University of Hamburg, Hamburg (Germany); Shick, Alexander B. [Institute of Physics ASCR, Prague (Czech Republic); Havela, Ladislav [Charles University, Prague (Czech Republic); Lichtenstein, Alexander I. [University of Hamburg, Hamburg (Germany)

    2010-07-01

    We provide a numerically efficient procedure to perform LDA+Hubbard I calculations including self-consistency over the charge density in the FP-LAPW basis. The method is applied to Pu, Am, and PuAm and PuCe alloys. Our results for valence photoemission spectra (PES) agree with experimental data and with previous LDA+DMFT calculations. Analysis of the J=5/2 and J=7/2 contributions to the f-occupation supports the intermediate-coupling picture of f-states in heavy actinides. The electronic specific heat coefficient is calculated for PuAm and PuCe alloys in reasonable agreement with recent experiments. We show that Pu atoms keep their mixed-valence character in these alloys. Next, we study electronic and spectral properties of Pu-based superconductor PuCoGa{sub 5} and obtain good agreement with experimental PES. Finally, we analyze surface effects. In Pu monolayer, we find substantial modification of PES due to 5f-electron localization consistent with experimental observations.

  2. The FP420 R&D Project: Higgs and New Physics with forward protons at the LHC

    CERN Document Server

    Albrow, M G; Arneodo, Michele; Atoian, G; Barlow, R; Beaumont, W; Bonnet, L; Brandt, A; Bussey, P; Buttar, C; Butterworth, J M; Carter, M; Cox, B E; Dattola, D; Da Via, C; de Favereau, J; D'Enterria, David; De Remigis, P; De Roeck, Albert; De Wolf, Eddi A; Duarte, P; Ellis, John R.; Florins, B; Forshaw, J R; Freestone, J; Goulianos, Konstantin A; Gronberg, J; Grothe, M; Gunion, J F; Hasi, J; Heinemeyer, S; Hollar, Jonathan J; Houston, S; Issakov, V; Jones, Roger M; Kelly, M; Kenney, C; Khoze, V A; Kolya, S; Konstantinidis, N; Kowalski, H; Lanni, F; Larsen, H E; Liu, S L; Lyapine, A; Loebinger, Frederick K; Marshall, R; Martin, A D; Monk, James William; Nasteva, Irina; Nemegeer, P; Obertino, M M; Orava, R; O'Shea, V; Pal, A; Parker, S; Pater, J; Perrot, A L; Pierzchala, T; Pilkington, A D; Pinfold, James L; Piotrzkowski, Krzysztof; Plano, W; Poblaguev, A; Popov, V; Potter, K M; Radeka, V; Rescia, S; Roncarolo, F; Rostovtsev, A; Rouby, X; Ruspa, M; Ryskin, M G; Santoro, A; Schul, N; Sellers, G; Solano, A; Spivey, S; Stirling, W J; Swoboda, D; Tasevsky, M; Thompson, R; Tsang, T; Van Mechelen, P; Vilela Pereira, A; Watts, S J; Warren, M R M; Weiglein, G; Wengler, T; White, Sebastian N; Winter, B; Yao, Y; Zaborov, D; Zampieri, A; Zeller, M; Zhokin, A

    2009-01-01

    We present the FP420 R&D project, which has been studying the key aspects of the development and installation of a silicon tracker and fast-timing detectors in the LHC tunnel at 420 m from the interaction points of the ATLAS and CMS experiments. These detectors would measure precisely very forward protons in conjunction with the corresponding central detectors as a means to study Standard Model (SM) physics, and to search for and characterise New Physics signals. This report includes a detailed description of the physics case for the detector and, in particular, for the measurement of Central Exclusive Production, pp --> p + phi + p, in which the outgoing protons remain intact and the central system phi may be a single particle such as a SM or MSSM Higgs boson. Other physics topics discussed are gamma-gamma and gamma-p interactions, and diffractive processes. The report includes a detailed study of the trigger strategy, acceptance, reconstruction efficiencies, and expected yields for a particular p p --> ...

  3. Reduction of polyhedrin mRNA and protein expression levels in Sf9 and Hi5 cell lines, but not in Sf21 cells, infected with Autographa californica multiple nucleopolyhedrovirus fp25k mutants.

    Science.gov (United States)

    Cheng, Xin-Hua; Hillman, Christopher C; Zhang, Chuan-Xi; Cheng, Xiao-Wen

    2013-01-01

    During cell infection, the fp25k gene of baculoviruses frequently mutates, producing the few polyhedra (FP) per cell phenotype with reduced polyhedrin (polh) expression levels compared with wild-type baculoviruses. Here we report that the fp25k gene of the model baculovirus, Autographa californica multiple nucleopolyhedrovirus (AcMNPV), contains two hypermutable seven-adenine (A7) mononucleotide repeats (MNRs) that were mutated to A8 MNRs and a TTAA site that had host DNA insertions, producing fp25k mutants during Sf21 cell infection. The FP phenotype in Sf9 and Hi5 cells was more pronounced than in Sf21 cells. AcMNPV fp25k mutants produced similar levels of polyhedra or enhanced GFP, which were both under the control of the AcMNPV polh promoter for expression, in Sf21 cells but lower levels in Sf9 and Hi5 cells compared with AcMNPV with an intact fp25k gene. This correlated with the polh mRNA levels detected in each cell line. The majority of Sf21 cells infected with fp25 mutants showed high polh promoter-mediated GFP expression levels. Two cell lines subcloned from Sf21 cells that were infected with fp25k mutants showed different GFP expression levels. Furthermore, a small proportion of Hi5 cells infected with fp25k mutants showed higher production of polyhedra and GFP expression than the rest, and the latter was not correlated with increased m.o.i. Therefore, these data suggest that AcMNPV polh promoter-mediated gene expression activities differ in the three cell lines and are influenced by different cells within the cell line.

  4. Feasibility of reactivity worth measurements by perturbation method with Caliban and Silene experimental reactors

    Energy Technology Data Exchange (ETDEWEB)

    Casoli, Pierre; Authier, Nicolas [Commissariat a l' Energie Atomique, Centre d' Etudes de Valduc, 21120 Is-Sur-Tille (France)

    2008-07-01

    Reactivity worth measurements of material samples put in the central cavities of nuclear reactors allow to test cross section nuclear databases or to extract information about the critical masses of fissile elements. Such experiments have already been completed on the Caliban and Silene experimental reactors operated by the Criticality and Neutronics Research Laboratory of Valduc (CEA, France) using the perturbation measurement technique. Calculations have been performed to prepare future experiments on new materials, such as light elements, structure materials, fission products or actinides. (authors)

  5. Exercise Effects on Depressive Symptoms and Self-Worth in Overweight Children: A Randomized Controlled Trial*

    OpenAIRE

    Petty, Karen H.; Davis, Catherine L.; Tkacz, Joseph; Young-Hyman, Deborah; Waller, Jennifer L

    2009-01-01

    Objective To test the dose–response effects of an exercise program on depressive symptoms and self-worth in children. Method Overweight, sedentary children (N = 207, 7–11 years, 58% male, 59% Black) were randomly assigned to low or high dose (20 or 40 min/day) aerobic exercise programs (13 ± 1.6 weeks), or control group. Children completed the Reynolds Child Depression Scale and Self-Perception Profile for Children at baseline and posttest. Results A dose–response benefit of exercise was dete...

  6. Communicating the financial worth of the CNS through the use of fiscal reports.

    Science.gov (United States)

    Ferraro-McDuffie, A; Chan, J S; Jerome, A M

    1993-03-01

    To maintain the clinical nurse specialist's (CNS's) leading role within hospital nursing services, routine communication to hospital administration of the impact of the CNS role on the hospital's budget is imperative. The CNS group at Children's Hospital of The King's Daughters implemented a quarterly Fiscal Report to clarify the financial worth of CNS practice. The Fiscal Report presents cost savings and revenue generating activities utilizing the role components of the CNS. During fiscal year 1991, the CNS group reported a total impact of $1,600,000. This article describes in detail the use of the Fiscal Report.

  7. Analyses of eigenvalue bias and control rod worths in FFTF (Fast Flux Test Facility)

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, J.V.; Dobbin, K.D.; Wootan, D.W.; Campbell, L.R.

    1987-01-01

    The Fast Flux Test Facility (FFTF) core loading during its ninth operating cycle was significantly different from that of previous cycles because of the presence of the Core Demonstration Experiment (CDE). The CDE consists of a number of axially blanketed fuel assemblies and internal blankets prototypic of advanced oxide cores in Liquid Metal Reactors (LMR). In preparation for the Cycle 9 reload design effort, a careful assessment of control rod worth and reactivity calculations for Cycles 1 through 8 was made. The goal of this study was to establish calculational biases and reduce uncertainties factored into the reload design calculations. These analyses helped assure that the operational objectives for Cycle 9 were met.

  8. Are Libraries Worth Investing in?: Finnish University Libraries and their Effect on the National Economy

    Directory of Open Access Journals (Sweden)

    Vesa Kiviniemi

    2009-03-01

    Full Text Available The paper discusses the correlation between the growth of the gross national product (GNP of Finland and the library materials costs of the academic libraries during thirty years (1977–2006. Statistical data were used in the analysis and it was found that there is some correlation between the trends of these two. The paper discusses different possibilities for interpretation of this outcome, but the authors draw the conclusion that it is clearly worth investing in libraries as one tool to improve the knowledge economy.

  9. What Are You Worth? The Value of a Human Life and Its Impact on Personnel Recovery

    Science.gov (United States)

    2014-06-01

    reptiles , who typically have many young and take less care of them afterwards, most mammals only reproduce a small number of live young that must be...nurtured and protected.29 Because the number of offspring is small, each life is valuable and worth protecting.30 If one reptile offspring is lost...concludes with the assertion, “I will trust in my God and in the United States of America .” What does trust in the United States look like— is it trust

  10. The European FP7 ULTimateCO2 project: A comprehensive approach to study the long term fate of CO2 geological storage sites

    Science.gov (United States)

    Audigane, P.; Brown, S.; Dimier, A.; Pearce, J.; Frykman, P.; Maurand, N.; Le Gallo, Y.; Spiers, C. J.; Cremer, H.; Rutters, H.; Yalamas, T.

    2013-12-01

    The European FP7 ULTimateCO2 project aims at significantly advance our knowledge of specific processes that could influence the long-term fate of geologically stored CO2: i) trapping mechanisms, ii) fluid-rock interactions and effects on mechanical integrity of fractured caprock and faulted systems and iii) leakage due to mechanical and chemical damage in the well vicinity, iv) brine displacement and fluid mixing at regional scale. A realistic framework is ensured through collaboration with two demonstration sites in deep saline sandstone formations: the onshore former NER300 West Lorraine candidate in France (ArcelorMittal GeoLorraine) and the offshore EEPR Don Valley (former Hatfield) site in UK operated by National Grid. Static earth models have been generated at reservoir and basin scale to evaluate both trapping mechanisms and fluid displacement at short (injection) and long (post injection) time scales. Geochemical trapping and reservoir behaviour is addressed through experimental approaches using sandstone core materials in batch reactive mode with CO2 and impurities at reservoir pressure and temperature conditions and through geochemical simulations. Collection of data has been generated from natural and industrial (oil industry) analogues on the fluid flow and mechanical properties, structure, and mineralogy of faults and fractures that could affect the long-term storage capacity of underground CO2 storage sites. Three inter-related lines of laboratory experiments investigate the long-term evolution of the mechanical properties and sealing integrity of fractured and faulted caprocks using Opalinus clay of Mont Terri Gallery (Switzerland) (OPA), an analogue for caprock well investigated in the past for nuclear waste disposal purpose: - Characterization of elastic parameters in intact samples by measuring strain during an axial experiment, - A recording of hydraulic fracture flow properties by loading and shearing samples in order to create a 'realistic

  11. Quantitation of dopamine transporter blockade by methylphenidate: first in vivo investigation using [{sup 123}I]FP-CIT and a dedicated small animal SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Nikolaus, Susanne; Wirrwar, Andreas; Antke, Christina; Arkian, Shahram; Mueller, Hans-Wilhelm; Larisch, Rolf [Heinrich-Heine University, Clinic of Nuclear Medicine, Duesseldorf (Germany); Schramm, Nils [Research Center Juelich, Central Laboratory for Electronics, Juelich (Germany)

    2005-03-01

    The aim of this study was to investigate the feasibility of assessing dopamine transporter binding after treatment with methylphenidate in the rat using a recently developed high-resolution small animal single-photon emission computed tomograph (TierSPECT) and [{sup 123}I]FP-CIT. [{sup 123}I]FP-CIT was administered intravenously 1 h after intraperitoneal injection of methylphenidate (10 mg/kg) or vehicle. Animals underwent scanning 2 h after radioligand administration. The striatum was identified by superimposition of [{sup 123}I]FP-CIT scans with bone metabolism and perfusion scans obtained with {sup 99m}Tc-DPD and {sup 99m}Tc-tetrofosmin, respectively. As these tracers do not pass the blood-brain barrier, their distribution permits the identification of extracerebral anatomical landmarks such as the orbitae and the harderian glands. The cerebellum was identified by superimposing [{sup 123}I]FP-CIT scans with images of brain perfusion obtained with {sup 99m}Tc-HMPAO. Methylphenidate-treated animals and vehicle-treated animals yielded striatal equilibrium ratios (V''{sub 3}) of 0.24{+-}0.26 (mean {+-} SD) and 1.09{+-}0.42, respectively (ttest, two-tailed, p<0.0001). Cortical V''{sub 3} values amounted to 0.05{+-}0.28 (methylphenidate) and 0.3{+-}0.39 (saline, p=0.176). This first in vivo study of rat dopamine transporter binding after pre-treatment with methylphenidate showed a mean reduction of 78% in striatal [{sup 123}I]FP-CIT accumulation. The results can be interpreted in terms of a pharmacological blockade in the rat striatum and show that in vivo quantitation of dopamine transporter binding is feasible with [{sup 123}I]FP-CIT and the TierSPECT. This may be of future relevance for in vivo investigations on rat models of attention deficit/hyperactivity disorder. Furthermore, our findings suggest that investigations in other animal models, e.g. of Parkinson's and Huntington's disease, may be feasible using SPECT radioligands and

  12. An Improved FP-Growth with Hybrid MGSO-IRVM Classifier Approach used for Type-2 Diabetes Mellitus Diagnosis

    Directory of Open Access Journals (Sweden)

    K.Vembandasamy

    2015-12-01

    Full Text Available Diabetes is a chronic disease and major problem of morbidity and mortality in developing countries. Type-2 diabetes mellitus (T2DM is the most common type of diabetes and accounts for 90- 95% of all diabetes. In the medical field a predictive data mining association algorithms is used to diagnose the disease at the earlier stage which helps the physicians in the treatment planning procedure. Recently, an improved Frequent Pattern Growth (IFP-Growth with Hybrid Enhanced Artificial Bee Colony-Advanced Kernel Support Vector Machine (EABC-AKSVM classification is introduced with the capability to reduce the number of rules in diagnosing the diabetes. However, the detection accuracy and robust is less. To resolve this problem, an Improved Frequent Pattern Growth (IFP-Growth with Hybrid Modified Glowworm Swarm Optimization-Improved Relevance Vector Machine (MGSO-IRVM Classification based Association Rule Mining (ARM system is proposed in this work to generate effective rules. The proposed work consists of two phases: In first phase, improved FP-growth is proposed to efficiently mine frequent patterns even from uncertain medical database. This is achieved by creating additional array for each item in uncertain transactional database to keep the information of its superitem sets in IFP-tree redundant node generation through this step the computational cost is greatly reduced. In next phase, Hybrid MGSO-IRVM classifier is used to generate the association rules based on the frequent item sets, which avoids rule redundancy and conflicts during the rule mining process. Experimental results show that the proposed model is suitable and alternative model for medical classification to achieve greater accuracy, and to improve medical diagnosis.

  13. Hypoxia monitoring activities within the FP7 EU-project HYPOX: diverse approaches to understand a complex phenomenon

    Science.gov (United States)

    Janssen, F.; Waldmann, C.; Boetius, A.

    2012-04-01

    Hypoxic conditions in aquatic systems and the occurrence of 'dead zones' increase worldwide due to man-made eutrophication and global warming with consequences for biodiversity, ecosystem functions and services such as fisheries, aquaculture and tourism. Monitoring of hypoxia and its consequences has to (1) account for the appropriate temporal and spatial scales, (2) separate anthropogenic from natural drivers and long-term trends from natural variations, (3) assess ecosystem response, (4) use modeling tools for generalization and prediction, and (5) share data and obtained knowledge. In 2009 the EU FP7 project HYPOX (www.hypox.net) started out as a pioneering attempt to improve and integrate hypoxia observation capacities addressing these requirements. Target ecosystems selected for HYPOX cover a broad range of settings (e.g., hydrography, oxygenation status, biological activity, anthropogenic impact) and differ in their sensitivity towards change. Semi-enclosed basins with permanent anoxia (Black Sea, Baltic Sea), are included as well as seasonally or locally hypoxic land-locked systems (fjords, lagoons, lakes) and open ocean systems with high sensitivity to global warming (North Atlantic - Arctic transition). Adopted monitoring approaches involve autonomous, cabled, and shipboard instruments and include static and profiling moorings, benthic observatories, drifters, as well as classical CTD surveys. In order to improve observatory performance, project activities encompass developments of oxygen sensors as well as calibration procedures and technologies to reduce biofouling. Modeling and data assimilation are used to synthesize findings, to obtain an in-depth understanding of hypoxia causes and consequences, and to improve forecasting capacities. For integration of the collected information into a global oxygen observing system, results are disseminated through the HYPOX portal following GEOSS data sharing principles. This presentation will give an overview of

  14. Neutralization of improvised explosive devices by high-power lasers: research results from the FP7 project ENCOUNTER

    Science.gov (United States)

    Osterholz, J.; Lueck, M.; Lexow, B.; Wickert, M.

    2016-10-01

    The development of reliable techniques for the safe neutralization of improvised explosive devices (IEDs) is an active field of research. Recently, innovative approaches for the neutralization of IEDs were developed and tested within the FP7 project ENCOUNTER ("Explosive Neutralisation and Mitigation Countermeasures for IEDs in Urban/Civil Environment") and were compared to existing, established technologies. Here, the ENCOUNTER project is presented with a special focus on the neutralization of IEDs by high-power lasers. The working principle of the application of high-power lasers for the neutralization of explosive devices is based on thermal effects. Heating of the IEDs main charge may occur either by direct irradiation of the explosive material or by heat transfer through the main charge's confinement. The aim of the application of the laser is to achieve a low order burning reaction of the explosive charge and thus a controlled neutralization of the IED. Since laser beams allow for the directed transport of energy, this technique can be applied over long stand-off distances and has thus potential for an increase of the safety of clearing forces and population in the case of terroristic attacks in a civilian environment. Within the ENCOUNTER project, a laboratory environment has been set up which allows for the irradiation of IEDs with a laser power of up to 10 kW. Experiments have been carried out on a broad spectrum of different types of IEDs. The processes during neutralization were studied in detail with high-speed diagnostics. On the basis of these experimental data, the safety and the reliability of the application of the laser was analyzed, and recommendations to end users were given. In addition to the results of the ENCOUNTER project, approaches for the numerical simulation of the neutralization of IEDs are discussed.

  15. An optical pulse width modulation generator based on the injection-locking property of single mode FP-LD

    Science.gov (United States)

    Tran, Quoc Hoai; Nakarmi, Bikash; Won, Yong Hyub

    2013-03-01

    A novel simple optical pulse width modulation generator (OPWMG) based on injection-locking property of a single mode FP-LD (SMFP-LD) has been proposed and experimentally verified. The OPWMG consists of a SMFP-LD (which acts as comparator), an optical sinusoidal wave source (analog input), and a continuous optical beam (control signal). The power required for fully injection-locking the SMFP-LD acts as the referent power whereas the combination power of continuous optical beam and analog optical sinusoidal signals work as control signals for changing the duty cycle of the proposed OPWMG. The presence of only continuous optical beam is not sufficient to suppress the dominant mode of SMFP-LD with high ON/OFF contrast ratio; however, the application of additional sinusoidal wave of constant amplitude and frequency, the dominant mode of SMFP-LD can be suppressed for the certain time window. Since, injection-locking power is dependent with the combined power of input injected continuous beam and sinusoidal optical wave, the time window of injection-locking can be varied by changing input beam power which provides different duty cycle of 13% to 68% at the output. Current available schemes for generating PWM signals are in electrical domain, hence, they need to convert electrical signals into optical domain by using expensive O/E converters for application in optical control and signal processing. The proposed OPWMG scheme has several advantages, such as low cost, low power consumption (~0.5 mW) which can be used for various applications where the effect of EMI/EMR is considered as an important factor such as control circuit for high voltage converters in power plant and electrical vehicles.

  16. Self-compassion moderates body comparison and appearance self-worth's inverse relationships with body appreciation.

    Science.gov (United States)

    Homan, Kristin J; Tylka, Tracy L

    2015-09-01

    Although research on positive body image has increased, little research has explored which variables protect body appreciation during body-related threats. Self-compassion may be one such variable. Individuals high in self-compassion are mindful, kind, and nurturing toward themselves during situations that threaten their adequacy, while recognizing that being imperfect is part of "being human." In this study, we investigated whether two body-related threats (i.e., body comparison and appearance contingent self-worth) were more weakly related to body appreciation when self-compassion was high among an online sample of 263 women (Mage=35.26, SD=12.42). Results indicated that self-compassion moderated the inverse relationships between body related threats and body appreciation. Specifically, when self-compassion was very high, body comparison and appearance contingent self-worth were unrelated to body appreciation. However, when self-compassion was low, these relationships were strong. Self-compassion, then, may help preserve women's body appreciation during body-related threats.

  17. Is It Worth Saving?: The Condition of Archaeological Documentary Record and Strategies for Preservation

    Directory of Open Access Journals (Sweden)

    Douglas R. Givens

    1992-11-01

    Full Text Available "[Historical] objects are events which have finished happening, and conditions [are] no longer in existence. Only when they are no longer perceptible do they become objects of historical thought" (Collingwood 1946:233. Scholars engaged in research in the history of anthropology and archaeology have long been aware of the deplorable conditions in which records as to anthropology's development in time are found and stored. All too often the researcher finds records in individual and institutional hands that are physically degrading because of the lack of proper storage facilities, the fiscal inability to hire professional archivists, the usage of improper methods of acquisition and curation, and dwindling financial resources to properly care for materials. It is now the time to ask if anthropological records are worth saving, and if they are, what are the best strategies to be employed to ensure their survival and protection now and into the future. The purpose of this paper is to suggest that the records of the subdiscipline of archaeology are worth saving and that there is a great sense of urgency to get about the business of identification and preservation before archaeological documentary records are further destroyed due to neglect and the lack of means to ensure their future existence.  This paper will define the problems of identification and preservation of archaeological records as they exist now and suggest strategies to rectify those problems.

  18. The Consequences of State-Level Intrusions: A Risk Worth Taking?

    Directory of Open Access Journals (Sweden)

    Murdoch Watney

    2015-05-01

    Full Text Available Over the years states have intruded the cyberspace of other states. Does the offending state consider the consequences it may face for the intrusion under international law and/or at international level? Is the position at present so uncertain that a state may decide that the risk is worth taking in view of the problems experienced with establishing attribution or is the injured state being second guessed on its reaction? This discussion explores, with reference to examples of state-level intrusions, whether the intrusion is prohibited under the international law or not and the possible consequences the offending state may face. The danger exists that as countries develop and/or improve their cyber capabilities, they may follow the example of countries who had intruded the cyberspace of other countries. It will be difficult for the latter to preach restraint from the moral high ground. Past state behaviour illustrates that states will put national interests and aspirations above trust, openness and transparency in cyberspace. Cyberspace is becoming a crowded place where state behaviour necessitates governance otherwise cyberspace will become lawless to the detriment of all states including those states who in the past may have decided state-intrusion is a risk worth taking.

  19. IS IT WORTH GOING GREEN IN CROATIA? EMPIRICAL EVIDENCE FROM SMEs

    Directory of Open Access Journals (Sweden)

    Dubravka Pekanov Starčević

    2017-01-01

    Full Text Available Technological progress and innovations in production are the basis for increasing productivity and reducing operating costs. On the other hand, rapid development accompanied by neglected environmental issues has resulted in adverse effects on the environment, and thus on the entire society. The consequences on the environment occur in the form of natural disasters, climate change and global warming. In order to reduce the adverse effects on the environment, states have introduced legal provisions, such as pollution charges. Such charges represent the costs incurred by the company that consequently burden its financial result. On the other hand, those charges can be lower for companies that apply more efficient production methods. The question is whether it is worth for a company to be “green” and hence pay a lower charge, or not to take into account “green business” and pay a higher charge for using inefficient production methods. This paper will explore whether it is worth being green, i.e. whether improving production efficiency results in a reduction of production costs. The emphasis is thereby placed on small and medium-sized enterprises as generators of economic growth and green jobs. In order to give an adequate review of green business and green market in Croatia, authors will analyse the Eurobarometer survey Flash Eurobarometer 426, focusing on Croatian data (n=502. It is evident that “green business” is one of the main business areas in the context of sustainable and socially responsible business.

  20. Efficacy of a group-based multimedia HIV prevention intervention for drug-involved women under community supervision: project WORTH.

    Directory of Open Access Journals (Sweden)

    Nabila El-Bassel

    Full Text Available IMPORTANCE: This study is designed to address the need for evidence-based HIV/STI prevention approaches for drug-involved women under criminal justice community supervision. OBJECTIVE: We tested the efficacy of a group-based traditional and multimedia HIV/STI prevention intervention (Project WORTH: Women on the Road to Health among drug-involved women under community supervision. DESIGN, SETTING, PARTICIPANTS, AND INTERVENTION: We randomized 306 women recruited from community supervision settings to receive either: (1 a four-session traditional group-based HIV/STI prevention intervention (traditional WORTH; (2 a four-session multimedia group-based HIV/STI prevention intervention that covered the same content as traditional WORTH but was delivered in a computerized format; or (3 a four-session group-based Wellness Promotion intervention that served as an attention control condition. The study examined whether the traditional or multimedia WORTH intervention was more efficacious in reducing risks when compared to Wellness Promotion; and whether multimedia WORTH was more efficacious in reducing risks when compared to traditional WORTH. MAIN OUTCOMES AND MEASURES: Primary outcomes were assessed over the 12-month post-intervention period and included the number of unprotected sex acts, the proportion of protected sex acts, and consistent condom use. At baseline, 77% of participants reported unprotected vaginal or anal sex (n = 237 and 63% (n = 194 had multiple sex partners. RESULTS: Women assigned to traditional or multimedia WORTH were significantly more likely than women assigned to the control condition to report an increase in the proportion of protected sex acts (β = 0.10; 95% CI = 0.02-0.18 and a decrease in the number of unprotected sex acts (IRR = 0.72; 95% CI = 0.57-0.90. CONCLUSION AND RELEVANCE: The promising effects of traditional and multimedia WORTH on increasing condom use and high participation rates suggest

  1. Efficacy of a group-based multimedia HIV prevention intervention for drug-involved women under community supervision: project WORTH.

    Science.gov (United States)

    El-Bassel, Nabila; Gilbert, Louisa; Goddard-Eckrich, Dawn; Chang, Mingway; Wu, Elwin; Hunt, Tim; Epperson, Matt; Shaw, Stacey A; Rowe, Jessica; Almonte, Maria; Witte, Susan

    2014-01-01

    This study is designed to address the need for evidence-based HIV/STI prevention approaches for drug-involved women under criminal justice community supervision. We tested the efficacy of a group-based traditional and multimedia HIV/STI prevention intervention (Project WORTH: Women on the Road to Health) among drug-involved women under community supervision. We randomized 306 women recruited from community supervision settings to receive either: (1) a four-session traditional group-based HIV/STI prevention intervention (traditional WORTH); (2) a four-session multimedia group-based HIV/STI prevention intervention that covered the same content as traditional WORTH but was delivered in a computerized format; or (3) a four-session group-based Wellness Promotion intervention that served as an attention control condition. The study examined whether the traditional or multimedia WORTH intervention was more efficacious in reducing risks when compared to Wellness Promotion; and whether multimedia WORTH was more efficacious in reducing risks when compared to traditional WORTH. Primary outcomes were assessed over the 12-month post-intervention period and included the number of unprotected sex acts, the proportion of protected sex acts, and consistent condom use. At baseline, 77% of participants reported unprotected vaginal or anal sex (n = 237) and 63% (n = 194) had multiple sex partners. Women assigned to traditional or multimedia WORTH were significantly more likely than women assigned to the control condition to report an increase in the proportion of protected sex acts (β = 0.10; 95% CI = 0.02-0.18) and a decrease in the number of unprotected sex acts (IRR = 0.72; 95% CI = 0.57-0.90). The promising effects of traditional and multimedia WORTH on increasing condom use and high participation rates suggest that WORTH may be scaled up to redress the concentrated epidemics of HIV/STIs among drug-involved women in the criminal justice system. Clinical

  2. Assessing the Effect of Fuel Burnup on Control Rod Worth for HEU and LEU Cores of Gharr-1

    Directory of Open Access Journals (Sweden)

    E.K. Boafo

    2013-02-01

    Full Text Available An important parameter in the design and analysis of a nuclear reactor is the reactivity worth of the control rod which is a measure of the efficiency of the control rod to absorb excess reactivity. During reactor operation, the control rod worth is affected by factors such as the fuel burnup, Xenon concentration, Samarium concentration and the position of the control rod in the core. This study investigates the effect of fuel burnup on the control rod worth by comparing results of a fresh and an irradiated core of Ghana's Miniature Neutron Source Reactor for both HEU and LEU cores. In this study, two codes have been utilized namely BURNPRO for fuel burnup calculation and MCNP5 which uses densities of actinides of the irradiated fuel obtained from BURNPRO. Results showed a decrease of the control rod worth with burnup for the LEU while rod worth increased with burnup for the HEU core. The average thermal flux in both inner and outer irradiation sites also decreased significantly with burnup for both cores.

  3. Difluoro-lambda(5)-phosphinonitrile F(2)P[triple bond]N: matrix isolation and photoisomerization into FP=NF.

    Science.gov (United States)

    Zeng, Xiaoqing; Beckers, Helmut; Willner, Helge

    2009-01-01

    Splendid isolation: Monomeric phosphazene F(2)PN ((1)A(1)) was prepared for the first time through irradiation of F(2)PN(3) in an argon matrix with an ArF excimer laser (lambda=193 nm). Upon subsequent irradiation with a high-pressure mercury arc lamp (lambda=255 nm), F(2)PN undergoes a 1,2-fluorine shift to give iminophosphane cis-FP=NF.

  4. The Italian forest sites of FunDivEUROPE: a new FP7 project on the functional significance of forest biodiversity in Europe

    OpenAIRE

    Bussotti F; Coppi A; Pollastrini M; Feducci M; Baeten L; Scherer-Lorenzen M.; Verheyen K; Selvi F

    2012-01-01

    The Italian forest sites of FunDivEUROPE: a new FP7 project on the functional significance of forest biodiversity in Europe. FunDivEUROPE is a new project aiming at a deeper understanding of the role of forest diversity on ecosystem functions and service provisioning for society. This project combines three scientific platforms: experimental, exploratory and inventory. The exploratory platform is based on the observation of a broad range of properties, traits and ecological processes on a net...

  5. Hydrologic data for urban stormwater studies in the Dallas-Fort Worth area, Texas, 1992-94

    Science.gov (United States)

    Baldys, Stanley; Raines, T.H.; Mansfield, B.L.; Sandlin, J.T.

    1997-01-01

    This report presents precipitation and waterquality data from analyses of 210 samples collected at 30 storm-sewer outfall stations in the Dallas-Fort Worth area, Texas, during February 1992-November 1994. The data were collected to fulfill requirements mandated by the U.S. Environmental Protection Agency to the cities of Arlington, Dallas, Fort Worth, Garland, Irving, Mesquite, and Piano and to the Dallas and Fort Worth Districts of the Texas Department of Transportation to obtain a National Pollution Discharge Elimination System permit. Data were collected at storm-sewer outfall stations in drainage basins classified as singular land use, either residential, commercial, industrial, or highway. Also included are qualityassurance/quality-control data for samples collected in conjunction with the stormwater samples.

  6. The validity and reliability of contingencies of self-worth scale

    Directory of Open Access Journals (Sweden)

    Bayram Çetin

    2011-01-01

    Full Text Available The aim of the present study is to adapt Contingencies of Self-Worth Scale (CSWS, Crocker, Luhtanen, Cooper, & Bouvrette, 2003 which assess to seven domains on which people are likely to state their self-worth according to contingencies of self-worth model to Turkish and examine its psychometric properties. CSWS consists of 35 items constructed in a form of 7 sub-scale. The subscales are called: Other’s approval, Family Support, Appearance, Competition, Academic Competence, God’s Love, and Virtue. The sample consists of 211 (49% were male and 224 (51% were female. Before the validity and reliability studies, to examine the language equivalency of the scale the correlations between Turkish and English forms which were administered to 107 English teachers one-week interval were calculated. Results of language equivalency showed that the correlations between Turkish and English forms for each item ranged from .69 to .97. Exploratory factor analysis was performed to examine the factor structure of the scale according to data obtained Turkish students. EFA revealed a seven-factor solution which accounted for 63% of the variance and eigenvalue over 1.00. Fit index values of the model were RMSEA=.04, NFI=.97, CFI=.98, IFI=.99, RFI= .96, GFI=.96 and AGFI= .94. Depression-Anxiety-Stress Scale and Autonomy Subscale of Psychological Well-Being Scale was used for criterion-related validity. Correlations between subscales of CSWS and DASS were ranged from -.38 to 46. On the other hand, correlations between CSWS and Autonomous Subscale of PSWB were ranged from .-70 to .52. Cronbach Alpha for the subscales were found between .82 and .91 and the test-retest reliability coefficients were ranged from .76 to .89. Item-total correlations ranged from .30 to .46 for appearance, ranged from .32 to .44 for God’s love, ranged from .30 to .61 for competition, ranged from .30 to .43 for virtue, ranged from .31 to .36 for other’s approval, .38 to .72 for family

  7. The validity and reliability of contingencies of self-worth scale

    Directory of Open Access Journals (Sweden)

    Bayram Çetin

    2011-01-01

    Full Text Available The aim of the present study is to adapt Contingencies of Self-Worth Scale (CSWS, Crocker, Luhtanen, Cooper, & Bouvrette, 2003 which assess to seven domains on which people are likely to state their self-worth according to contingencies of self-worth model to Turkish and examine its psychometric properties. CSWS consists of 35 items constructed in a form of 7 sub-scale. The subscales are called: Other’s approval, Family Support, Appearance, Competition, Academic Competence, God’s Love, and Virtue. The sample consists of 211 (49% were male and 224 (51% were female. Before the validity and reliability studies, to examine the language equivalency of the scale the correlations between Turkish and English forms which were administered to 107 English teachers one-week interval were calculated. Results of language equivalency showed that the correlations between Turkish and English forms for each item ranged from .69 to .97. Exploratory factor analysis was performed to examine the factor structure of the scale according to data obtained Turkish students. EFA revealed a seven-factor solution which accounted for 63% of the variance and eigenvalue over 1.00. Fit index values of the model were RMSEA=.04, NFI=.97, CFI=.98, IFI=.99, RFI= .96, GFI=.96 and AGFI= .94. Depression-Anxiety-Stress Scale and Autonomy Subscale of Psychological Well-Being Scale was used for criterion-related validity. Correlations between subscales of CSWS and DASS were ranged from -.38 to 46. On the other hand, correlations between CSWS and Autonomous Subscale of PSWB were ranged from .-70 to .52. Cronbach Alpha for the subscales were found between .82 and .91 and the test-retest reliability coefficients were ranged from .76 to .89. Item-total correlations ranged from .30 to .46 for appearance, ranged from .32 to .44 for God’s love, ranged from .30 to .61 for competition, ranged from .30 to .43 for virtue, ranged from .31 to .36 for other’s approval, .38 to .72 for family

  8. Secondary natural gas recovery: Targeted applications for infield reserve growth in midcontinent reservoirs, Boonsville Field, Fort Worth Basin, Texas. Topical report, May 1993--June 1995

    Energy Technology Data Exchange (ETDEWEB)

    Hardage, B.A.; Carr, D.L.; Finley, R.J.; Tyler, N.; Lancaster, D.E.; Elphick, R.Y.; Ballard, J.R.

    1995-07-01

    The objectives of this project are to define undrained or incompletely drained reservoir compartments controlled primarily by depositional heterogeneity in a low-accommodation, cratonic Midcontinent depositional setting, and, afterwards, to develop and transfer to producers strategies for infield reserve growth of natural gas. Integrated geologic, geophysical, reservoir engineering, and petrophysical evaluations are described in complex difficult-to-characterize fluvial and deltaic reservoirs in Boonsville (Bend Conglomerate Gas) field, a large, mature gas field located in the Fort Worth Basin of North Texas. The purpose of this project is to demonstrate approaches to overcoming the reservoir complexity, targeting the gas resource, and doing so using state-of-the-art technologies being applied by a large cross section of Midcontinent operators.

  9. Alcohol use in college students: effects of level of self-esteem, narcissism, and contingencies of self-worth.

    Science.gov (United States)

    Luhtanen, Riia K; Crocker, Jennifer

    2005-03-01

    The unique effects of level of self-esteem, narcissism, and contingencies of self-worth assessed prior to college on alcohol use during the freshman year were examined in a longitudinal study of 620 college students. Narcissism predicted alcohol use, but level of self-esteem did not. Basing self-worth on appearance predicted more alcohol use, whereas the virtue, God's love, and academic competence contingencies predicted less alcohol use, independent of other personality measures and joining a sorority or a fraternity. Further, the virtue and academic competence contingencies were associated with decreases in alcohol use from the 1st to the 2nd semester.

  10. Astrobiology Road Mapping (AstRoMap) - A project within FP7 of the European Commission: First results

    Science.gov (United States)

    Gomez-Gomez, Felipe; Capria, Maria Teresa; Palomba, Ernesto; Walter, Nicolas; Rettberg, Petra; Muller, Christian; Horneck, Gerda

    AstRoMap (Astrobiology and Planetary Exploration Road Mapping) is a funded project formulated in the 5th Call of the European Commission FP7 framework. The main objectives of the AstRoMap are: 1. Identify the main astrobiology issues to be addressed by Europe in the next decades in relation with space exploration 2. Identify potential mission concepts that would allow addressing these issues 3. Identify the technology developments required to enable these missions 4. Provide a prioritized roadmap integrating science and technology activities as well as ground-based approach 5. Map scientific knowledge related to astrobiology in Europe To reach those objectives, AstRoMap is executed within the following steps: 1. Community consultation. In order to map the European astrobiology landscape and to provide a collaborative networking platform for this community, the AstRoMap project hosts a database of scientists (European and beyond) interested in astrobiology and planetary exploration (see: http://www.astromap.eu/database.html). It reflects the demography and the research and teaching activities of the astrobiology community, as well as their professional profiles and involvement in astrobiology projects. Considering future aspects of astrobiology in Europe, the need for more astrobiology-dedicated funding programmes at the EU level, especially for cross-disciplinary groups, was stressed. This might eventually lead to the creation of a European laboratory of Astrobiology, or even of a European Astrobiology Institute. 2. Workshops organisation. On the basis of the feedbacks from the community consultation, the potential participants and interesting topics are being identified to take part in the following workshops: 1-. Origin of organic compounds, steps to life; 2. Physico-chemical boundary conditions for habitability 3. Biosignatures as facilitating life detection 4. Origin of the Solar system 3. Astrobiology road-mapping. Based on the results and major conclusions

  11. Formación continua en centros de FP y actividades de innovación en las Pymes industriales

    Directory of Open Access Journals (Sweden)

    Lavía, Cristina

    2012-02-01

    Full Text Available The current economic crisis is affecting Spain with special force. Within that context, the relationships between the education system and the economic system become a key issue. The aim of this paper is to make a contribution to the understanding of the relationships between vocational training (VT centres and small and medium-sized firms (SMEs. Our study is based on a survey of industrial SMEs from two Northern Spanish autonomous communities (Basque Country and Navarre. The different types of SME-VT centre relationship are analyzed, and special attention if devoted to new forms of relationships among those agents (mainly continuous training, and to the possible effects of SME-VT centre collaboration upon the firms’ innovation processes. We show that, right now, continuous training activities are a key form of relationship between VT centres and SMEs. That type of relationship acquires an strategic importance from the point of view of the coordination between the training system and the innovation system.

    La crisis actual, que afecta con especial virulencia a España, obliga a reflexionar sobre las relaciones entre el sistema educativo y el sistema económico. En este trabajo, basado en una encuesta a pequeñas y medianas empresas industriales de las comunidades autónomas vasca y navarra, se pretende avanzar en el conocimiento de las relaciones entre los centros de Formación Profesional y las empresas. Se prestará especial atención a las nuevas formas de relación entre ambos agentes (especialmente la formación continua, y al efecto que la colaboración con los centros de FP pueda tener sobre los procesos de innovación de las empresas. Se muestra que, en la actualidad, las actividades de formación continua constituyen una forma de colaboración importante para las empresas y estratégica desde el punto de vista del ajuste entre el sistema de formación y el sistema de innovación.

  12. The ISS SOLAR payload data preservation in the frame of the PERICLES FP-7 project: metadata aspects.

    Science.gov (United States)

    Muller, Christian; Pandey, Praveen

    2016-04-01

    PERICLES (Promoting and Enhancing the Reuse of Information throughout the Content Lifecycle exploiting Evolving Semantics) is an FP7 project started on February 2013. It aims at preserving by design large and complex data sets. PERICLES is coordinated by King's College London, UK and its partners are University of Borås (Sweden), CERTH- ITI (Greece), DotSoft (Greece), Georg-August-Universität Göttingen (Germany), University of Liverpool (UK), Space Application Services (Belgium), XEROX France and University of Edinburgh (UK). Two additional partners provide the two case studies: Tate Gallery (UK) brings the digital art and media case study and B.USOC (Belgian Users Support and Operations Centre) brings the space science case study . PERICLES addresses the life-cycle of large and complex data sets in order to cater for the evolution of context of data sets and user communities, including groups unanticipated when the data was created. Semantics of data sets are thus also expected to evolve and the project includes elements which could address the reuse of data sets at periods where the data providers and even their institutions are not available any more. PERICLES uses the Linked Resources Model (LRM) which will be compared with the OAIS standard. In this study we present the space science case associated with PERICLES. B.USOC supports experiments on the International Space Station and is the curator of the collected data and operations history. B.USOC has chosen to analyse the SOLAR payload flying since 2008 on the ESA COLUMBUS module of the ISS as the PERICLES prime space science case. Solar observation data are prime candidates for long term data preservation as variabilities of the solar spectral irradiance have an influence on earth climate. The nature of the data to be preserved for the reuse of the current SOLAR series is much more extended than a simple set of time tagged tables of spectral irradiances, it is an important inventory of more than 50 classes

  13. Challenges in Evaluating the Severity of Fibropapillomatosis: A Proposal for Objective Index and Score System for Green Sea Turtles (Chelonia mydas) in Brazil.

    Science.gov (United States)

    Rossi, Silmara; Sánchez-Sarmiento, Angélica María; Vanstreels, Ralph Eric Thijl; Dos Santos, Robson Guimarães; Prioste, Fabiola Eloisa Setim; Gattamorta, Marco Aurélio; Grisi-Filho, José Henrique Hildebrand; Matushima, Eliana Reiko

    2016-01-01

    Fibropapillomatosis (FP) is a neoplastic disease that affects marine turtles worldwide, especially green sea turtles (Chelonia mydas). FP tumors can develop on the body surface of marine turtles and also internally in the oral cavity and viscera. Depending on their quantity, size and anatomical distribution, these tumors can interfere with hydrodynamics and the ability to feed, hence scoring systems have been proposed in an attempt to quantify the clinical manifestation of FP. In order to establish a new scoring system adapted to geographic regions, we examined 214 juvenile green sea turtles with FP caught or rescued at Brazilian feeding areas, counted their 7466 tumors and classified them in relation to their size and anatomical distribution. The patterns in quantity, size and distribution of tumors revealed interesting aspects in the clinical manifestation of FP in specimens studied in Brazil, and that FP scoring systems developed for other areas might not perform adequately when applied to sea turtles on the Southwest Atlantic Ocean. We therefore propose a novel method to evaluate the clinical manifestation of FP: fibropapillomatosis index (FPI) that provides the Southwest Atlantic fibropapillomatosis score (FPSSWA). In combination, these indexing and scoring systems allow for a more objective, rapid and detailed evaluation of the severity of FP in green sea turtles. While primarily designed for the clinical manifestation of FP currently witnessed in our dataset, this index and the score system can be adapted for other areas and compare the characteristics of the disease across regions. In conclusion, scoring systems to classify the severity of FP can assist our understanding on the environmental factors that modulate its development and its impacts on the individual and population health of green sea turtles.

  14. Challenges in Evaluating the Severity of Fibropapillomatosis: A Proposal for Objective Index and Score System for Green Sea Turtles (Chelonia mydas) in Brazil

    Science.gov (United States)

    Rossi, Silmara; Sánchez-Sarmiento, Angélica María; Vanstreels, Ralph Eric Thijl; dos Santos, Robson Guimarães; Prioste, Fabiola Eloisa Setim; Gattamorta, Marco Aurélio; Grisi-Filho, José Henrique Hildebrand; Matushima, Eliana Reiko

    2016-01-01

    Fibropapillomatosis (FP) is a neoplastic disease that affects marine turtles worldwide, especially green sea turtles (Chelonia mydas). FP tumors can develop on the body surface of marine turtles and also internally in the oral cavity and viscera. Depending on their quantity, size and anatomical distribution, these tumors can interfere with hydrodynamics and the ability to feed, hence scoring systems have been proposed in an attempt to quantify the clinical manifestation of FP. In order to establish a new scoring system adapted to geographic regions, we examined 214 juvenile green sea turtles with FP caught or rescued at Brazilian feeding areas, counted their 7466 tumors and classified them in relation to their size and anatomical distribution. The patterns in quantity, size and distribution of tumors revealed interesting aspects in the clinical manifestation of FP in specimens studied in Brazil, and that FP scoring systems developed for other areas might not perform adequately when applied to sea turtles on the Southwest Atlantic Ocean. We therefore propose a novel method to evaluate the clinical manifestation of FP: fibropapillomatosis index (FPI) that provides the Southwest Atlantic fibropapillomatosis score (FPSSWA). In combination, these indexing and scoring systems allow for a more objective, rapid and detailed evaluation of the severity of FP in green sea turtles. While primarily designed for the clinical manifestation of FP currently witnessed in our dataset, this index and the score system can be adapted for other areas and compare the characteristics of the disease across regions. In conclusion, scoring systems to classify the severity of FP can assist our understanding on the environmental factors that modulate its development and its impacts on the individual and population health of green sea turtles. PMID:27936118

  15. Because You're Worth It: Women's daily hair care routines in contemporary Britain

    Directory of Open Access Journals (Sweden)

    Sabine Hielscher

    2016-11-01

    Full Text Available Hair care is a significant international industry – estimated to be worth over £1.44 billion in contemporary Britain (Mintel 2015. Given this, it is perhaps not so surprising to learn that British women spend on average £40,000 on their hair over a lifetime (Sharkey 2014. However, despite women's preoccupation with hair, social science research has paid little attention to this area (McCracken 1997; Cox 1999. Most previous studies have examined the changing nature of styles and fashion, offering valuable insights into its symbolic, ritualistic and religious nature and in turn demonstrating the conspicuous aspects of hair (Cox 1999; Biddle-Perry and Cheang 2008. While the public nature of hair has been documented, what is rarely explored is the private world of hair care, often part of a wider network of day-to-day domestic routines (Shove 2003.

  16. A glimpse behind the mask: facets of narcissism and feelings of self-worth.

    Science.gov (United States)

    Zeigler-Hill, Virgil; Besser, Avi

    2013-01-01

    This study examined the connections that the facets of narcissism captured by the Narcissistic Personality Inventory (NPI; Raskin & Hall, 1979) and the Pathological Narcissism Inventory (PNI; Pincus et al., 2009) have with self-esteem. This was accomplished by asking 372 participants to complete measures of narcissism and self-esteem level as well as daily diary measures concerning their state self-esteem and daily experiences. Our analyses found that the facets of narcissism differed in their associations with average level of self-esteem, fluctuations in state self-esteem over time, and self-esteem reactions following daily events. These results suggest that it is important to consider specific facets of narcissism when examining feelings of self-worth rather than relying on broader composite measures of narcissistic personality features. Implications of these results for our understanding of the dynamics of the narcissistic personality are discussed.

  17. Water quality and streamflow data for the West Fork Trinity River in Forth Worth, Texas

    Science.gov (United States)

    McCutcheon, S.C.

    1985-01-01

    Water-quality data were collected on a 13.6-mile reach of the West Fork Trinity River in Fort Worth, Texas to test a dynamic Lagrangian model. Flow was steady. Loads of dissolved constituents varied with time at the beginning of the study reach and in the reach, primarily because of photosynthesis. River quality was fairly good despite low dissolved oxygen measured in the headwaters and the significant sewage load from the tributaries. Diel and longitudinal trends were defined by sampling at fixed sites and by following dyed parcels of water. Nitrification, deoxygenation, reaeration, and photosynthesis affected the dissolved oxygen balance. Independent estimates of some of the rate coefficients were 0.1 to 0.2, 0.8, and 0 to 3.6 , all per day, for deoxygenation, nitrification, and reaeration, respectively. (USGS)

  18. Is it real? Can we win? Is it worth doing? Managing risk and reward in an innovation portfolio.

    Science.gov (United States)

    Day, George S

    2007-12-01

    Minor innovations make up most of a company's development portfolio, on average, but they never generate the growth companies seek. The solution, says Day--the Geoffrey T. Boisi Professor of Marketing and a codirector of the Mack Center for Technological Innovation at Wharton--is for companies to undertake a systematic, disciplined review of their innovation portfolios and increase the number of major innovations at an acceptable level of risk. Two tools can help them do this. The first, called the risk matrix, graphically reveals the distribution of risk across a company's entire innovation portfolio. The matrix allows companies to estimate each project's probability of success or failure, based on how big a stretch it is for the firm to undertake. The less familiar the product or technology and the intended market, the higher the risk. The second tool, dubbed the R-W-W (real-win-worth it) screen, allows companies to evaluate the risks and potential of individual projects by answering six fundamental questions about each one: Is the market real? Explores customers' needs, their willingness to buy, and the size of the potential market. Is the product real? Looks at the feasibility of producing the innovation. Can the product be competitive? and Can our company be competitive? Investigate how well suited the company's resources and management are to compete in the marketplace with the product. Will the product be profitable at an acceptable risk? Explores the financial analysis needed to assess an innovation's commercial viability. Last, Does launching the product make strategic sense? examines the project's fit with company strategy and whether management supports it.

  19. Framework Collaboration Agreement with the Institute of Physics Belgrade (IPB) Dr. Alexandar Belic Framework Collaboration Agreement with the Faculty of Physics of University of Belgrade (FP-UB) Prof. Petar Adzic

    CERN Multimedia

    Pantelia, Anna

    2014-01-01

    Framework Collaboration Agreement with the Institute of Physics Belgrade (IPB) Dr. Alexandar Belic Framework Collaboration Agreement with the Faculty of Physics of University of Belgrade (FP-UB) Prof. Petar Adzic

  20. A Dialogical Epistemology for Educational Evaluation

    Science.gov (United States)

    Penuel, William R.

    2010-01-01

    A central task of evaluation is to use systematic inquiry to judge the merit, worth, and significance of programs. As a field in education, evaluation began to mature during the 1960s, when policy makers began funding researchers to study the impact of Great Society programs. Since that time, evaluation and policy-making have been intertwined,…

  1. A Dialogical Epistemology for Educational Evaluation

    Science.gov (United States)

    Penuel, William R.

    2010-01-01

    A central task of evaluation is to use systematic inquiry to judge the merit, worth, and significance of programs. As a field in education, evaluation began to mature during the 1960s, when policy makers began funding researchers to study the impact of Great Society programs. Since that time, evaluation and policy-making have been intertwined,…

  2. Serotonin transporters in dopamine transporter imaging: a head-to-head comparison of dopamine transporter SPECT radioligands 123I-FP-CIT and 123I-PE2I

    DEFF Research Database (Denmark)

    Ziebell, Morten; Holm-Hansen, Signe; Thomsen, Gerda

    2010-01-01

    the SPECT radioligands (123)I-2-β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane ((123)I-FP-CIT) and (123)I-N-(3-iodoprop-2E-enyl)-2-β-carbomethoxy-3β-(4-methylphenyl) nortropane ((123)I-PE2I), which has a 10-fold higher selectivity than (123)I-FP-CIT for DAT versus SERT [corrected]....

  3. Configurations of actual and perceived motor competence among children: Associations with motivation for sports and global self-worth.

    Science.gov (United States)

    Bardid, Farid; De Meester, An; Tallir, Isabel; Cardon, Greet; Lenoir, Matthieu; Haerens, Leen

    2016-12-01

    The present study used a person-centred approach to examine whether different profiles based on actual and perceived motor competence exist in elementary school children. Multilevel regression analyses were conducted to explore how children with different motor competence-based profiles might differ in their autonomous motivation for sports and global self-worth. Validated questionnaires were administered to 161 children (40% boys; age=8.82±0.66years) to assess their perceived motor competence, global self-worth, and motivation for sports. Actual motor competence was measured with the Körperkoordinationstest für Kinder. Cluster analyses identified four motor competence-based profiles: two groups were characterized by corresponding levels of actual and perceived motor competence (i.e., low-low and high-high) and two groups were characterized by divergent levels of actual and perceived motor competence (i.e., high-low and low-high). Children in the low-low and high-low group displayed significantly lower levels of autonomous motivation for sports and lower levels of global self-worth than children in the low-high and high-high group. These findings emphasize that fostering children's perceived motor competence might be crucial to improve their motivation for sports and their global self-worth. Teachers and instructors involved in physical education and youth sports should thus focus on both actual and perceived motor competence.

  4. 78 FR 37785 - Foreign-Trade Zone (FTZ) 196-Fort Worth, Texas; Notification of Proposed Production Activity...

    Science.gov (United States)

    2013-06-24

    ... Production Activity; Flextronics International USA, Inc. (Mobile Phone Assembly and Kitting); Fort Worth..., testing, packaging, warehousing and distribution of mobile phones. Pursuant to 15 CFR 400.14(b), FTZ... FTZ Board. Production under FTZ procedures could exempt Flextronics from customs duty payments on...

  5. Global Sensitivity and Data-Worth Analyses in iTOUGH2: User's Guide

    Energy Technology Data Exchange (ETDEWEB)

    Wainwright, Haruko Murakami [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Earth Sciences Division; Univ. of California, Berkeley, CA (United States); Finsterle, Stefan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Earth Sciences Division; Univ. of California, Berkeley, CA (United States)

    2016-07-15

    This manual explains the use of local sensitivity analysis, the global Morris OAT and Sobol’ methods, and a related data-worth analysis as implemented in iTOUGH2. In addition to input specification and output formats, it includes some examples to show how to interpret results.

  6. Externally Contingent and Unstable Self-Worth as Predictors of Depression in College Women: A 3-Month Study

    Science.gov (United States)

    Lopez, Frederick G.; Thorne, Brittany; Schoenecker, Sydney; Siffert, Kevin; Chaliman, Rebecca; Castleberry, Erica

    2014-01-01

    Undergraduate women completed measures of externally contingent self-worth, self-esteem instability, and depression at the beginning (Time 1) and again 3 months later near the end (Time 2) of an academic semester. Findings indicated that when Time 1 depression scores were controlled for, each Time 1 facet of self-esteem made significant…

  7. When a Picture Isn't Worth 1000 Words: Learners Struggle to Find Meaning in Data Visualizations

    Science.gov (United States)

    Stofer, Kathryn A.

    2016-01-01

    The oft-repeated phrase "a picture is worth a thousand words" supposes that an image can replace a profusion of words to more easily express complex ideas. For scientific visualizations that represent profusions of numerical data, however, an untranslated academic visualization suffers the same pitfalls untranslated jargon does. Previous…

  8. 77 FR 39343 - Agency Information Collection (Income-Net Worth and Employment Statement) Activity Under OMB Review

    Science.gov (United States)

    2012-07-02

    ... any correspondence. FOR FURTHER INFORMATION CONTACT: Denise McLamb, Enterprise Records Service (005R1B... current employment, dependency, and family income and net worth information to determine a claimant's... Secretary. Denise McLamb, Program Analyst, Enterprise Records Service. BILLING CODE 8320-01-P...

  9. Externally Contingent and Unstable Self-Worth as Predictors of Depression in College Women: A 3-Month Study

    Science.gov (United States)

    Lopez, Frederick G.; Thorne, Brittany; Schoenecker, Sydney; Siffert, Kevin; Chaliman, Rebecca; Castleberry, Erica

    2014-01-01

    Undergraduate women completed measures of externally contingent self-worth, self-esteem instability, and depression at the beginning (Time 1) and again 3 months later near the end (Time 2) of an academic semester. Findings indicated that when Time 1 depression scores were controlled for, each Time 1 facet of self-esteem made significant…

  10. Friendship Predictors of Global Self-Worth and Domain-Specific Self-Concepts in University Students with and without Learning Disability

    Science.gov (United States)

    Shany, Michal; Wiener, Judith; Assido, Michal

    2013-01-01

    This study investigated the association among friendship, global self-worth, and domain-specific self-concepts in 102 university students with and without learning disabilities (LD). Students with LD reported lower global self-worth and academic self-concept than students without LD, and this difference was greater for women. Students with LD also…

  11. Implementation of a worth-oriented monitoring system by means of a medium-sized power supply company; Implementierung eines wertorientierten Steuerungssystems inklusive Beispiel anhand eines mittelgrossen Energieversorgungsunternehmens

    Energy Technology Data Exchange (ETDEWEB)

    Mierzwa, Thomas

    2009-07-01

    The book under consideration reports on a systematization as well as on a theoretical presentation of existing worth-oriented control concepts. The author points out the computation as well as the possibility of an implementation of worth-orientated sizes on the basis of an exemplary power supply company.

  12. Identified versus Introjected Approach and Introjected Avoidance Motivations in School and in Sports: The Limited Benefits of Self-Worth Strivings

    Science.gov (United States)

    Assor, Avi; Vansteenkiste, Maarten; Kaplan, Avi

    2009-01-01

    On the basis of self-determination theory (Ryan & Deci, 2000), the authors examined whether 2 different types of introjected motivation--an avoidant type aimed at avoiding low self-worth and an approach type aimed at attaining high self-worth--are both associated with a less positive pattern of correlates relative to identified…

  13. Associations between the parent-child relationship and adolescent self-worth: a genetically informed study of twin parents and their adolescent children.

    Science.gov (United States)

    McAdams, Tom A; Rijsdijk, Fruhling V; Narusyte, Jurgita; Ganiban, Jody M; Reiss, David; Spotts, Erica; Neiderhiser, Jenae M; Lichtenstein, Paul; Eley, Thalia C

    2017-01-01

    Low self-worth during adolescence predicts a range of emotional and behavioural problems. As such, identifying potential sources of influence on self-worth is important. Aspects of the parent-child relationship are often associated with adolescent self-worth but to date it is unclear whether such associations may be attributable to familial confounding (e.g. genetic relatedness). We set out to clarify the nature of relationships between parental expressed affection and adolescent self-worth, and parent-child closeness and adolescent self-worth. We used data from the Twin and Offspring Study in Sweden, a children-of-twins sample comprising 909 adult twin pairs with adolescent children. Using these data we were able to apply structural equation models with which we could examine whether associations remained after accounting for genetic transmission. Results demonstrated that parent-child closeness and parental-expressed affection were both phenotypically associated with adolescent self-worth. Associations could not be attributed to genetic relatedness between parent and child. Parent-child closeness and parental affection are associated with adolescent self-worth above and beyond effects attributable to genetic relatedness. Data were cross-sectional, so the direction of effects cannot be confirmed but findings support the notion that positive parent-child relationships increase adolescent self-worth. © 2016 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.

  14. Friendship Predictors of Global Self-Worth and Domain-Specific Self-Concepts in University Students with and without Learning Disability

    Science.gov (United States)

    Shany, Michal; Wiener, Judith; Assido, Michal

    2013-01-01

    This study investigated the association among friendship, global self-worth, and domain-specific self-concepts in 102 university students with and without learning disabilities (LD). Students with LD reported lower global self-worth and academic self-concept than students without LD, and this difference was greater for women. Students with LD also…

  15. Comparison of the performance of {sup 18}F-FP-CIT brain PET/MR and simultaneous PET/CT: A preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Sang Don; Chun, Kyung Ah [Dept. of Nuclear Medicine, Yeungnam University Hospital, Daegu (Korea, Republic of)

    2016-09-15

    {sup 18}F-FP-CIT [{sup 1'}8F-fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane] has been well established and used for the differential diagnosis of atypical parkinsonian disorders. Recently, combined positron emission tomography (PET)/magnetic resonance (MR) was proposed as a viable alternative to PET/computed tomography (CT). The aim of this study was to compare the performances of conventional {sup 18}F-FP-CIT brain PET/CT and simultaneous PET/MR by visual inspection and quantitative analysis. Fifteen consecutive patients clinically suspected of having Parkinson's disease were recruited for the study.{sup 18}F-FP-CIT PET was performed during PET/CT and PET/MR. PET/CT image acquisition was started 90 min after intravenous injection of {sup 18}F-FP-CIT and then PET/MR images were acquired. Dopamine transporter (DAT) density in bilateral striatal subregions was assessed visually. Quantitative analyses were performed on bilateral striatal volumes of interest (VOIs) using average standardized uptake values (SUVmeans). Intraclass correlation coefficients (ICCs) and their 95 % confidence intervals (CIs) were assessed to compare PET/CT and PET/MR data. Bland-Altman plots were drawn to perform method-comparisons. All subjects showed a preferential decrease in DAT binding in the posterior putamen (PP), with relative sparing of the ventral putamen (VP). Bilateral striatal subregional binding ratio (BR) determined PET/CT and PET/MR demonstrated close interequipment correspondence (BRright caudate - ICC, 0.944; 95 % CI, 0.835-0.981, BRleft caudate - ICC, 0.917; 95 % CI, 0.753-0.972, BRright putamen - ICC, 0.976; 95 % CI, 0.929-0.992 and BRleft putamen - ICC, 0.970; 95 % CI, 0.911-0.990, respectively), and Bland-Altman plots showed interequipment agreement between the two modalities. It is known that MR provides more information about anatomical changes associated with brain diseases and to enable the anatomical allocations of

  16. FP-LAPW investigation of structural, electronic, linear and nonlinear optical properties of ZnIn2Te4 defect-chalcopyrite

    OpenAIRE

    AYEB, Y.; OUAHRANI, T.; Khenata, R.; Reshak, Ali H.; RACHED, D.; Bouhemadou, A.; ARRAR, R.

    2010-01-01

    A theoretical study of structural, electronic, linear and nonlinear optical properties of ZnIn2Te4 defect-chalcopyrite is presented using the full-potential linearized augmented plane-wave (FP-LAPW) method. The exchange and correlation potential is treated by the generalized-gradient approximation (GGA). Moreover, the Engel and Vosko GGA formalism (EV-GGA) is also used to improve the band gap results. The lattice parameters (a, c) and the atomic positions (x, y and z) are optimized and found ...

  17. Potential environmental benefits of improving recycling of polyolefines – LCA of Magnetic density separation (MDS) developed in the EU FP7 funded project W2Plastic

    DEFF Research Database (Denmark)

    Olsen, Stig Irving; Bonou, Alexandra

    2012-01-01

    The core of the EU FP7 funded project W2Plastic is development of a magnetic density separation (MDS) of polyolefines in order to improve the sorting efficiency of these polymer types in different waste fractions. As part of the project a life cycle assessment is performed in order to firstly...... identify eco-design criteria for the development and secondly to document the potential environmental improvement of polyolefin recycling using the MDS technology. A preliminary study focusing solely on the carbon footprint benefits of recycling plastic waste compared to virgin production of polymers...

  18. A comparison of core degradation phenomena in the CORA, QUENCH, Phébus SFD and Phébus FP experiments

    Energy Technology Data Exchange (ETDEWEB)

    Haste, T., E-mail: tim.haste@irsn.fr [Institut de Radioprotection et de Sûreté Nucléaire, IRSN, BP 3, F-13115 St. Paul-lez-Durance Cedex (France); Steinbrück, M., E-mail: martin.steinbrueck@kit.edu [Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Barrachin, M., E-mail: marc.barrachin@irsn.fr [Institut de Radioprotection et de Sûreté Nucléaire, IRSN, BP 3, F-13115 St. Paul-lez-Durance Cedex (France); Luze, O. de, E-mail: olivier.de-luze@irsn.fr [Institut de Radioprotection et de Sûreté Nucléaire, IRSN, BP 3, F-13115 St. Paul-lez-Durance Cedex (France); Grosse, M., E-mail: mirco.grosse@kit.edu [Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Stuckert, J., E-mail: juri.stuckert@kit.edu [Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany)

    2015-03-15

    Highlights: • The results of the experiments CORA, QUENCH and Phébus SFD/FP are summarised. • All phenomena expected up to melt movement to the lower head are shown consistently. • Separate-effect tests performed at KIT and IRSN aid improve their modelling. • Data from the integral tests help independent validation of new and improved models. • The improved codes will help reduce uncertainties in safety-critical areas for core degradation. - Abstract: Over the past 20 years, integral fuel bundle experiments performed at IRSN Cadarache, France (Phébus-SFD and Phébus FP – fission heated) and at Karlsruhe Institute of Technology, Germany (CORA and QUENCH – electrically heated), accompanied by separate-effect tests, have provided a wealth of detailed information on core degradation phenomena that occur under severe accident conditions, relevant to such safety issues as in-vessel retention of the core, recovery of the core by water reflood, hydrogen generation and fission product release. These data form an important basis for development and validation of severe accident analysis codes such as ASTEC (IRSN/GRS, EC) and MELCOR (USNRC/SNL, USA) that are used to assess the safety of current and future reactor designs, so helping to reduce the uncertainty associated with such code predictions. Following the recent end of the Phébus FP project, it is appropriate now to compare the core degradation phenomena observed in these four major experimental series, indicating the main conclusions that have been drawn. This covers subjects such as early phase degradation up to loss of rod-like geometry (all the series), late phase degradation and the link between fission product release and core degradation (Phébus FP), oxidation phenomena (all the series), reflood behaviour (CORA and QUENCH), as well as particular topics such as the effects of control rod material and fuel burn-up on core degradation. It also outlines the separate-effects experiments performed to

  19. The Validation Activities of the APhoRISM EC 7FP Project, Aimed at Post Seismic Damage Mapping, Through a Combined Use of EOS and Ground Data

    Science.gov (United States)

    Devanthery, N.; Luzi, G.; Stramondo, S.; Bignami, C.; Pierdicca, N.; Wegmuller, U.; Romaniello, V.; Anniballe, R.; Piscini, A.; Albano, M.; Moro, M.; Crosetto, M.

    2016-08-01

    The estimate of damage after an earthquake using spaceborne remote sensing data is one of the main application of the change detection methodologies widely discussed in literature. APhoRISM - Advanced PRocedures for volcanIc and Seismic Monitoring is a collaborative European Commission project (FP7-SP ACE- 2013-1) addressing the development of innovative methods, using space and ground sensors to support the management and mitigation of the seismic and the volcanic risk. In this paper a novel approach aimed at damage assessment based on the use of a priori information derived by different sources in a preparedness phase is described and a preliminary validation is shown.

  20. Evaluation of a single round polymerase chain reaction assay using dried blood spots for diagnosis of HIV-1 infection in infants in an African setting

    Directory of Open Access Journals (Sweden)

    Ng'ayo Musa

    2011-02-01

    Full Text Available Abstract Background The aim of this study was to develop an economical 'in-house' single round polymerase chain reaction (PCR assay using filter paper-dried blood spots (FP-DBS for early infant HIV-1 diagnosis and to evaluate its performance in an African setting. Methods An 'in-house' single round PCR assay that targets conserved regions in the HIV-1 polymerase (pol gene was validated for use with FP-DBS; first we validated this assay using FP-DBS spiked with cell standards of known HIV-1 copy numbers. Next, we validated the assay by testing the archived FP-DBS (N = 115 from infants of known HIV-1 infection status. Subsequently this 'in-house' HIV-1 pol PCR FP-DBS assay was then established in Nairobi, Kenya for further evaluation on freshly collected FP-DBS (N = 186 from infants, and compared with findings from a reference laboratory using the Roche Amplicor® HIV-1 DNA Test, version 1.5 assay. Results The HIV-1 pol PCR FP-DBS assay could detect one HIV-1 proviral copy in 38.7% of tests, 2 copies in 46.9% of tests, 5 copies in 72.5% of tests and 10 copies in 98.1% of tests performed with spiked samples. Using the archived FP-DBS samples from infants of known infection status, this assay was 92.8% sensitive and 98.3% specific for HIV-1 infant diagnosis. Using 186 FP-DBS collected from infants recently defined as HIV-1 positive using the commercially available Roche Amplicor v1.5 assay, 178 FP-DBS tested positive by this 'in-house' single-round HIV-1 pol PCR FP-DBS PCR assay. Upon subsequent retesting, the 8 infant FP-DBS samples that were discordant were confirmed as HIV-1 negative by both assays using a second blood sample. Conclusions HIV-1 was detected with high sensitivity and specificity using both archived and more recently collected samples. This suggests that this 'in-house' HIV-1 pol FP-DBS PCR assay can provide an alternative cost-effective, reliable and rapid method for early detection of HIV-1 infection in infants.

  1. Effect of S-1 chemotherapy and FP chemotherapy on prognosis, imaging characteristics and serum marker levels after operation for gastric carcinoma

    Institute of Scientific and Technical Information of China (English)

    Qing-Hao Gong; Yi-Ting Cai; Hai-Qun Chen; Chao-Feng Zhang; Gang Dai; Song-Ming Zhu

    2016-01-01

    Objective:To analyze the effect of S-1 chemotherapy and FP chemotherapy on prognosis, imaging characteristics and serum marker levels after operation for gastric carcinoma. Methods:A total of 68 patients with gastric cancer who underwent radical surgery were included in the study and divided into observation group and control group patients (n=34) according to random number table. Control group received FP chemotherapy, observation group received S-1 chemotherapy, and then differences in serum tumor markers, illness-related factors, nutrition indexes and T cell immune function values were compared between two groups.Results: After observation group received systematic chemotherapy, serum tumor markers such as MMP-9, MMP-2, MG7-Ag, TSGF, CA72-4, CA19-9, TP and DpD as well as illness-related factors such as DKK1, MK, Leptin, Exosome and OPN were all lower than those of control group (P<0.05); nutrition and cellular immune function indexes such as TP, ALB, PA, CD4+ T and CD4+ T/ CD8+ T values were higher than those of control group and CD8+ T value was lower than that of control group (P<0.05).Conclusions:S-1 chemotherapy after operation for gastric carcinoma can inhibit the tumor activity and optimize patients’ overall condition, and it has positive clinical significance.

  2. Automatic on-line detection system design research on internal defects of metal materials based on optical fiber F-P sensing technology

    Science.gov (United States)

    Xia, Liu; Shan, Ning; Chao, Ban; Caoshan, Wang

    2016-10-01

    Metal materials have been used in aerospace and other industrial fields widely because of its excellent characteristics, so its internal defects detection is very important. Ultrasound technology is used widely in the fields of nondestructive detection because of its excellent characteristic. But the conventional detection instrument for ultrasound, which has shortcomings such as low intelligent level and long development cycles, limits its development. In this paper, the theory of ultrasound detection is analyzed. A computational method of the defects distributional position is given. The non-contact type optical fiber F-P interference cavity structure is designed and the length of origin cavity is given. The real-time on-line ultrasound detecting experiment devices for internal defects of metal materials is established based on the optical fiber F-P sensing system. The virtual instrument of automation ultrasound detection internal defects is developed based on LabVIEW software and the experimental study is carried out. The results show that this system can be used in internal defect real-time on-line locating of engineering structures effectively. This system has higher measurement precision. Relative error is 6.7%. It can be met the requirement of engineering practice. The system is characterized by simple operation, easy realization. The software has a friendly interface, good expansibility, and high intelligent level.

  3. "Not worth doing prenatal care": an ethnographic study of a low-income community

    Directory of Open Access Journals (Sweden)

    Patrícia L. F Santa Rosa

    2015-08-01

    Full Text Available Objective. The aim of this study was to explore the reasons why pregnant women do not seek prenatal care (PNC. Methodology. The ethnographic method was used in a low-income Brazilian community. Ethnographic interviews were performed with 11 postpartum women who did not seek PNC in their last pregnancy. Results. The cultural sub-themes used to express reasons for not seeking PNC included: "I found out I was pregnant too late and did not have enough time to receive PNC," "I did not receive PNC because I had to hide the pregnancy to avoid problems," "I had to address urgent issues and could not seek PNC," "The services are not good and going to the doctor when not ill is only for rich people," and cultural theme: "PNC is not worth pursuing: it is unnecessary and there are too many obstacles to receiving it." Conclusion. The main strategies that should be considered to increase adherence to PNC are better access and integrality through the use of adequate management criteria.

  4. Human dignity in the prophetic traditions: Upholding human worth in a context of dehumanisation

    Directory of Open Access Journals (Sweden)

    L. Claassens

    2011-09-01

    Full Text Available This article proposes that the theme of human dignity offers a fruitful avenue to
    explore the interrelated themes of justice, vocation and human responsibility in the
    biblical traditions. Human dignity is most evident in the notion of the Imago Dei,
    i.e., the claim in Genesis 1:26-27 that humans, both male and female, are created in
    the image of God. This powerful theological claim has led to some rich theological
    reflection by Christian and Jewish interpreters who have argued for the inherent
    worth of every human being whose dignity is a gracious gift bestowed by the Creator
    God. Nevertheless, in the Hebrew Bible there are numerous instances where this
    dignity of individuals and groups are threatened, obscured and violated. And yet, it
    is exactly in the midst of these situations of dehumanisation that the conversation
    on what it means to be human becomes most urgent. For instance, in prophets like
    Isaiah, it is within the depths of the social justice violations that threaten the well
    being of the society’s most vulnerable members that one encounters the prophet’s
    persistent critique that upholds the dignity of each member of the society.

  5. The quantitative precipitation estimation system for Dallas-Fort Worth (DFW) urban remote sensing network

    Science.gov (United States)

    Chen, Haonan; Chandrasekar, V.

    2015-12-01

    The Dallas-Fort Worth (DFW) urban radar network consists of a combination of high resolution X band radars and a standard National Weather Service (NWS) Next-Generation Radar (NEXRAD) system operating at S band frequency. High spatiotemporal-resolution quantitative precipitation estimation (QPE) is one of the important applications of such a network. This paper presents a real-time QPE system developed by the Collaborative Adaptive Sensing of the Atmosphere (CASA) Engineering Research Center for the DFW urban region using both the high resolution X band radar network and the NWS S band radar observations. The specific dual-polarization radar rainfall algorithms at different frequencies (i.e., S- and X-band) and the fusion methodology combining observations at different temporal resolution are described. Radar and rain gauge observations from four rainfall events in 2013 that are characterized by different meteorological phenomena are used to compare the rainfall estimation products of the CASA DFW QPE system to conventional radar products from the national radar network provided by NWS. This high-resolution QPE system is used for urban flash flood mitigations when coupled with hydrological models.

  6. What's Worth Talking About? Information Theory Reveals How Children Balance Informativeness and Ease of Production.

    Science.gov (United States)

    Bannard, Colin; Rosner, Marla; Matthews, Danielle

    2017-07-01

    Of all the things a person could say in a given situation, what determines what is worth saying? Greenfield's principle of informativeness states that right from the onset of language, humans selectively comment on whatever they find unexpected. In this article, we quantify this tendency using information-theoretic measures and report on a study in which we tested the counterintuitive prediction that children will produce words that have a low frequency given the context, because these will be most informative. Using corpora of child-directed speech, we identified adjectives that varied in how informative (i.e., unexpected) they were given the noun they modified. In an initial experiment ( N = 31) and in a replication ( N = 13), 3-year-olds heard an experimenter use these adjectives to describe pictures. The children's task was then to describe the pictures to another person. As the information content of the experimenter's adjective increased, so did children's tendency to comment on the feature that adjective had encoded. Furthermore, our analyses suggest that children balance informativeness with a competing drive to ease production.

  7. Sense of life worth living (ikigai) and incident functional disability in elderly Japanese: The Tsurugaya Project.

    Science.gov (United States)

    Mori, Kentaro; Kaiho, Yu; Tomata, Yasutake; Narita, Mamoru; Tanji, Fumiya; Sugiyama, Kemmyo; Sugawara, Yumi; Tsuji, Ichiro

    2017-04-01

    To test the hypothesis that elderly persons who feel ikigai (a sense of life worth living) have a lower risk of incident functional disability than those who do not. Recent studies have suggested that ikigai impacts on mortality. However, its impact upon disability is unknown. The aim of the present study was to investigate the association between ikigai and incident functional disability among elderly persons. We conducted a prospective cohort study of 830 Japanese elderly persons aged ≥70years as a comprehensive geriatric assessment in 2003. Information on ikigai was collected by self-reported questionnaire. Data on functional disability were retrieved from the public Long-term Care Insurance database in which participants were followed up for 12years. Hazard ratios (HRs) and 95% confidence intervals (CIs) for incidence of functional disability were calculated for three groups delineated according to the presence of ikigai ("no", "uncertain" or "yes") using the Cox proportional hazards regression model. The 12-year incidence of functional disability was 53.3% (442 cases). As compared with the "no" group, the multiple-adjusted HR (95% CI) of incident functional disability was 0.61 (0.36-1.02) for the "uncertain" group and 0.50 (0.30-0.84) for the "yes" group. A stronger degree of ikigai is significantly associated with a lower risk of incident functional disability. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Extending Data Worth Analyses to Select Multiple Observations Targeting Multiple Forecasts.

    Science.gov (United States)

    Vilhelmsen, Troels N; Ferré, Ty P A

    2017-09-15

    Hydrological models are often set up to provide specific forecasts of interest. Owing to the inherent uncertainty in data used to derive model structure and used to constrain parameter variations, the model forecasts will be uncertain. Additional data collection is often performed to minimize this forecast uncertainty. Given our common financial restrictions, it is critical that we identify data with maximal information content with respect to forecast of interest. In practice, this often devolves to qualitative decisions based on expert opinion. However, there is no assurance that this will lead to optimal design, especially for complex hydrogeological problems. Specifically, these complexities include considerations of multiple forecasts, shared information among potential observations, information content of existing data, and the assumptions and simplifications underlying model construction. In the present study, we extend previous data worth analyses to include: simultaneous selection of multiple new measurements and consideration of multiple forecasts of interest. We show how the suggested approach can be used to optimize data collection. This can be used in a manner that suggests specific measurement sets or that produces probability maps indicating areas likely to be informative for specific forecasts. Moreover, we provide examples documenting that sequential measurement election approaches often lead to suboptimal designs and that estimates of data covariance should be included when selecting future measurement sets. © 2017, National Ground Water Association.

  9. Analysis of High Temperature Reactor Control Rod Worth for the Initial and Full Core

    Science.gov (United States)

    Oktajianto, Hammam; Setiawati, Evi; Anam, Khoirul; Sugito, Heri

    2017-01-01

    Control rod is one important component in a nuclear reactor. In nuclear reactor operations the control rod functions to shut down the reactor. This research analyses ten control rods worth of HTR (High Temperature Reactor) at initial and full core. The HTR in this research adopts HTR-10 China and HTR- of pebble bed. Core calculations are performed by using MCNPX code after modelling the entire parts of core in condition of ten control rods fully withdrawn, all control rods in with 20 cm ranges of depth and the use of one control rod. Pebble bed and moderator balls are distributed in the core zone using a Body Centred Cubic (BCC) lattice by ratio of 57:43. The research results are obtained that the use of one control rod will decrease the reactor criticality of 2.04±0.12 %Δk/k at initial core and 1.57±0.10 %Δk/k at full core. The deeper control rods are in, the lesser criticality of reactor is with reactivity of ten control rods of 16.41±0.11 %Δk/k at initial core and 15.43±0.11 %Δk/k at full core. The results show that the use of ten control rods at full core will keep achieving subcritical condition even though the reactivity is smaller than reactivity at initial core.

  10. Investigation of control rod worth and nuclear end of life of BWR control rods

    Energy Technology Data Exchange (ETDEWEB)

    Magnusson, Per

    2008-01-15

    This work has investigated the Control Rod Worth (CRW) and Nuclear End of Life (NEOL) values for BWR control rods. A study of how different parameters affect NEOL was performed with the transport code PHOENIX4. It was found that NEOL, expressed in terms of {sup 10}B depletion, can be generalized beyond the conditions for which the rod is depleted, such as different power densities and void fractions, the corresponding variation in the NEOL will be about 0.2-0.4% {sup 10}B. It was also found that NEOL results for different fuel types and different fuel enrichments have a variation of about 2-3% in {sup 10}B depletion. A comparative study on NHOL and CRW was made between PHOENIX4 and the stochastic Monte Carlo code MCNP. It was found that there is a significant difference, both due to differences in the codes and to limitations in the geometrical modeling in PHOENIX4. Since MCNP is considered more physically correct, a methodology was developed to calculate the nuclear end of life of BWR control rods with MCNP. The advantages of the methodology are that it does not require other codes to perform the depletion of the absorber material, it can describe control rods of any design and it can deplete the control rod absorber material without burning the fuel. The disadvantage of the method is that is it time-consuming.

  11. Worth it? Findings from a study of how academics assess students’ Web 2.0 activities

    Directory of Open Access Journals (Sweden)

    Kathleen Gray

    2012-02-01

    Full Text Available Educational commentators have offered many pedagogical rationales for using Web 2.0 to support learning in higher education, and academics are being encouraged to find ways for their students to use social web technologies. Questions arise as to the value of these activities compared to more conventional assignments, and whether implementing such changes to student assessment is worth the effort. We conducted a survey of academics’ assessment of students’ Web 2.0 activities in Australian universities and found that this form of assessment is being conducted by a small number of academics, in a range of fields of study, but mainly in Humanities and Social Sciences, with varying kinds of intended and actual learning outcomes. Blogging and wiki-writing predominate, low and medium-stakes assessment are most common, and different methods of marking and feedback are in use. Qualitative feedback from the survey and follow-up interviews gave further insights into benefits and challenges of Web 2.0 assessment in relation to pedagogy, policy and practice. It appears that academics’ conservative approaches to conducting assessment and their novice approaches to utilising social web technologies are factors which seriously limit realising the potential of Web 2.0 for medium or high-stakes assessment.

  12. High-resolution Rainfall Mapping in Dallas-Fort Worth (DFW) Urban Network of Radars at Multiple Frequencies

    Science.gov (United States)

    Chandra, Chandrasekar V.; Chen*, Haonan

    2015-04-01

    Urban flash flood is one of the most commonly encountered hazardous weather phenomena. Unfortunately, the rapid urbanization has made the densely populated areas even more vulnerable to flood risks. Hence, accurate and timely monitoring of rainfall at high spatiotemporal resolution is critical to severe weather warning and civil defense, especially in urban areas. However, it is still challenging to produce high-resolution products based on the large S-band National Weather Service (NWS) Next-Generation Weather Radar (NEXRAD), due to the sampling limitations and Earth curvature effect. Since 2012, the U.S. National Science Foundation Engineering Research Center (NSF-ERC) for Collaborative Adaptive Sensing of the Atmosphere (CASA) has initiated the development of Dallas-Fort Worth (DFW) radar remote sensing network for urban weather hazards mitigation. The DFW urban radar network consists of a combination of high-resolution X-band radars and a standard NWS NEXRAD radar operating at S-band frequency. High-resolution quantitative precipitation estimation (QPE) is one of the major research goals in the deployment of this urban radar network. It has been shown in the literature that the dual-polarization radar techniques can improve the QPE accuracy over traditional single-polarization radars by rendering more measurements to enhance the data quality, providing more information about rain drop size distribution (DSD), and implying more characteristics of different hydrometeor types. This paper will present the real-time dual-polarization CASA DFW QPE system, which is developed via fusion of observations from both the high-resolution X band radar network and the S-band NWS radar. The specific dual-polarization rainfall algorithms at different frequencies (i.e., S- and X-band) will be described in details. In addition, the fusion methodology combining observations at different temporal resolution will be presented. In order to demonstrate the capability of rainfall

  13. Determining the mechanical strength of CO2-induced reaction zones in wellbore cement: is it worth it?

    Science.gov (United States)

    Hangx, Suzanne; Marcelis, Fons; van der Linden, Arjan; Liteanu, Emilia

    2015-04-01

    CO2 injection, either for long-term CO2 storage (CCS) or Enhanced Oil Recovery (EOR), strongly hinges on maintaining storage integrity. Injection and legacy wells penetrating the caprock pose one of the most likely points of leakage. In order to be able to predict the long-term integrity of such wellbores, it's important to understand their chemical, hydrological and mechanical behaviour, and how it may change due to CO2 exposure. Generally, in response to CO2/brine/cement interactions, a number of different reaction zones are observed, each with their own chemical, and hence mechanical, signature. To aid mechanical modelling efforts, assessing the risk of cement failure caused by stress and temperature changes, knowledge is required of the strength of each of these zones. We performed experiments on Class G Portland cement to investigate the chemical-mechanical coupling due to CO2-exposure. Batch reaction experiments, in the presence of CO2-rich brine, were performed under typical storage conditions (T = 65° C, PCO2 = 8 MPa) for various periods of time (1, 2, 3, 4, 5 and 6 months). After exposure, mechanical tests were performed on the observed reaction zones, using the so-called core scratching technique, to evaluate the unconfined compressive strength (UCS) as a function of exposure time. Chemical analyses (CT-imaging, SEM microscopy, EDX chemical analysis) showed the formation of three reaction zones, similarly to what has been observed in other studies. Measurements of the mechanical strength of these different zones showed highly variable results. Such variations have also been observed in other studies, using different measurement techniques. The large variability in strength measurements is most likely an inherent result of the heterogenic nature of cement, which affects the extent and location of reaction throughout the sample. This begs the question: is it worth studying the mechanical strength of reaction-induced zones in cement? Or will it suffice to

  14. Environmental Assessment Addressing the 301st Fighter Wing Managed Airspace, Naval Air Station Joint Reserve Base, Fort Worth, Texas

    Science.gov (United States)

    2009-05-01

    Bosque County 317 6 36 22 174 6 7 199 236 22 337 303 254 16 144 108 16 171 6 36 174 171 16 67 190 183 190 281...A-15 Brownwood MOA Brady North MOA Brady High MOA & Brady Low MOA 281 B1 VR1 01 Mason County Bell County Bosque County Brown County Burnet... Bosque County Brown County Comanche County Mineral Wells Weatherford Stephenville Wichita Falls Texas Oklahoma Dallas- Ft. Worth San Antonio Austin

  15. Contingencies of Self-Worth and Psychological Distress in Iranian Patients Seeking Cosmetic Surgery: Integrative Self-Knowledge as Mediator.

    Science.gov (United States)

    Valikhani, Ahmad; Goodarzi, Mohammad Ali

    2017-08-01

    Although previous studies have shown that people applying for cosmetic surgery experience high-intensity psychological distress, important variables that function as protective factors have rarely been the subject of study in this population. Therefore, this study aims to investigate the role of low and high self-knowledge in experiencing psychological distress and contingencies of self-worth to appearance and approval from others and to identify the mediatory role of the integrative self-knowledge in patients seeking cosmetic surgery. Eighty-eight patients seeking cosmetic surgery were selected and completed the contingencies of self-worth and integrative self-knowledge scales, as well as the depression, anxiety and stress scale. Data were analyzed using multivariate analysis of variance (MANOVA) and path analysis using 5000 bootstrap resampling. The results of MANOVA showed that patients seeking cosmetic surgery with high self-knowledge had lower levels of depression, anxiety and stress compared to patients with low self-knowledge. They also gained lower scores in contingencies of self-worth to appearance and approval from others. The results of path analysis indicated that self-knowledge is a complete mediator in the relationship between contingencies of self-worth to appearance and approval from others and psychological distress. Based on the results of this study, it can be concluded that self-knowledge as a protective factor plays a major role in relation to the psychological distress experienced by the patients seeking cosmetic surgery. In fact, by increasing self-knowledge among this group of patients, their psychological distress can be decreased. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

  16. QR Codes in the Library: Are They Worth the Effort? Analysis of a QR Code Pilot Project

    OpenAIRE

    Wilson, Andrew M

    2012-01-01

    The literature is filled with potential uses for Quick Response (QR) codes in the library. Setting, but few library QR code projects have publicized usage statistics. A pilot project carried out in the Eda Kuhn Loeb Music Library of the Harvard College Library sought to determine whether library patrons actually understand and use QR codes. Results and analysis of the pilot project are provided, attempting to answer the question as to whether QR codes are worth the effort for libraries.

  17. Characterization of control rod worths and fuel rod power peaking factors in the university of Utah TRIGA Mark I reactor

    OpenAIRE

    Alroumi Fawaz; Kim Donghoon; Schow Ryan; Jevremovic Tatjana

    2016-01-01

    Control rod reactivity (worths) for the three control rods and fuel rod power peaking factors in the University of Utah research reactor (100 kW TRIGA Mark I) are characterized using the AGENT code system and the results described in this paper. These values are compared to the MCNP6 and existing experimental measurements. In addition, the eigenvalue, neutron spatial flux distributions and reaction rates are analyzed and discussed. The AGENT code system is ...

  18. Sex work and three dimensions of self-esteem: self-worth, authenticity and self-efficacy.

    Science.gov (United States)

    Benoit, Cecilia; Smith, Michaela; Jansson, Mikael; Magnus, Samantha; Flagg, Jackson; Maurice, Renay

    2017-05-26

    Sex work is assumed to have a negative effect on self-esteem, nearly exclusively expressed as low self-worth, due to its social unacceptability and despite the diversity of persons, positions and roles within the sex industry. In this study, we asked a heterogeneous sample of 218 Canadian sex workers delivering services in various venues about how their work affected their sense of self. Using thematic analysis based on a three-dimensional conception of self-esteem - self-worth (viewing oneself in a favourable light), authenticity (being one's true self) and self-efficacy (competency) - we shed light on the relationship between involvement in sex work and self-esteem. Findings demonstrate that the relationship between sex work and self-esteem is complex: the majority of participants discussed multiple dimensions of self-esteem and often spoke of how sex work had both positive and negative effects on their sense of self. Social background factors, work location and life events and experiences also had an effect on self-esteem. Future research should take a more complex approach to understanding these issues by considering elements beyond self-worth, such as authenticity and self-efficacy, and examining how sex workers' backgrounds and individual motivations intersect with these three dimensions.

  19. Long-term sodium and chloride surface water exports from the Dallas/Fort Worth region.

    Science.gov (United States)

    Steele, M K; Aitkenhead-Peterson, J A

    2011-07-15

    Sodium and chloride in surface water are typically related to urbanization and population density and can have a significant impact on drinking water sources and the subsequent salinity of aquatic ecosystems. While the majority of research has focused on the impact of deicing salts on urban surface waters in colder climates, the effect of urbanization on sodium and chloride concentrations has been found to occur in warmer climates. This study investigated long-term exports of sodium and chloride from watersheds with increasing urbanization in the humid subtropical Dallas-Fort Worth region. We compared exports to characteristics of urbanization: urban land cover, impervious surface area, and calculated contributions from wastewater discharges. Long-term data (1980-2008) were obtained from five USGS gages located in and around the cities. Exports were calculated by regression analysis between concentrations and discharge and normalized for time and the watershed area. Grab samples were collected from June 2009 to May 2010 and sodium and chloride concentrations quantified. Our results show a strong positive relationship between the mean annual sodium and chloride exports from each watershed and the percent urban land cover and impervious surface area. Long-term increases in sodium and chloride fluxes were found for the three watersheds with the highest percentage of urban land cover. The single largest contributor was wastewater effluent that was estimated to contribute approximately half of the total loads in the three urbanized watersheds. Atmospheric deposition and deicing salts accounted for small amounts of the total export for urbanized watersheds. The source of the remaining salt load is still unknown and may be a combination of non-point sources. Estimates of urban salt exports were similar to estimates from northern watersheds affected by deicing salts.

  20. Worthing Physiological Score vs Revised Trauma Score in Outcome Prediction of Trauma patients; a Comparative Study

    Science.gov (United States)

    Nakhjavan-Shahraki, Babak; Yousefifard, Mahmoud; Hajighanbari, Mohammad Javad; Karimi, Parviz; Baikpour, Masoud; Mirzay Razaz, Jalaledin; Yaseri, Mehdi; Shahsavari, Kavous; Mahdizadeh, Fatemeh; Hosseini, Mostafa

    2017-01-01

    Introduction: Awareness about the outcome of trauma patients in the emergency department (ED) has become a topic of interest. Accordingly, the present study aimed to compare the rapid trauma score (RTS) and worthing physiological scoring system (WPSS) in predicting in-hospital mortality and poor outcome of trauma patients. Methods: In this comparative study trauma patients brought to five EDs in different cities of Iran during the year 2016 were included. After data collection, discriminatory power and calibration of the models were assessed and compared using STATA 11. Results: 2148 patients with the mean age of 39.50±17.27 years were included (75.56% males). The AUC of RTS and WPSS models for prediction of mortality were 0.86 (95% CI: 0.82-0.90) and 0.91 (95% CI: 0.87-0.94), respectively (p=0.006). RTS had a sensitivity of 71.54 (95% CI: 62.59-79.13) and a specificity of 97.38 (95% CI: 96.56-98.01) in prediction of mortality. These measures for the WPSS were 87.80 (95% CI: 80.38-92.78) and 83.45 (95% CI: 81.75-85.04), respectively. The AUC of RTS and WPSS in predicting poor outcome were 0.81 (95% CI: 0.77-0.85) and 0.89 (95% CI: 0.85-0.92), respectively (p<0.0001). Conclusion: The findings showed a higher prognostic value for the WPSS model in predicting mortality and severe disabilities in trauma patients compared to the RTS model. Both models had good overall performance in prediction of mortality and poor outcome. PMID:28286838

  1. Variable-density effects on the worth of pressure data for characterizing aquifer permeability

    Science.gov (United States)

    Yoon, Seonkyoo; Kang, Peter; Williams, John

    2017-04-01

    We investigate variable-density effects on the worth of pressure data for estimating aquifer permeability. In variable-density flow and transport in porous media, the pressure distribution is transient even without changes in boundary conditions because the variable-density gradient itself can induce gravity currents. This means that the transient pressure distribution is implicitly coupled with additional information from the variable-density gradient, and consequently the data can be more informative than in density invariant cases for aquifer characterization. To systematically investigate the informativeness of the transient pressure data, we analyze the performance of permeability characterization employing the pressure data under various levels of variable-density effects. The variable-density effects can be controlled by a mixed convection ratio, which is a ratio between two characteristic convections: free convection due to a density gradient and forced convection due to a hydraulic gradient. A 2D density-dependent flow and transport model is established to simulate a coastal aquifer system where density flow occurs due to density difference between saline seawater and fresh water. An ensemble Kalman filter (EnKF) with convariance localization and inflation is used to sequentially estimate heterogeneous aquifer permeability fields by conditioning on real-time pressure head data. The performance of the permeability estimation is analyzed in terms of accuracy of estimated permeability fields, and predictability of arrival times of breakthrough curves in a push-pull setting. The analysis shows that the accuracy and predictability of the inverse estimation can be most improved when the free convection is balanced with the forced convection, which corresponds to the mixed convection ratio being one. This demonstrates that the pressure data is most informative for characterizing aquifer permeability fields when the two characteristic convections are balanced.

  2. 'Acupuncture for antenatal depression: It's worth giving it a go' - A qualitative study.

    Science.gov (United States)

    Ormsby, Simone M; Dahlen, Hannah G; Ee, Carolyn C; Keedle, Hazel; Smith, Caroline A

    2017-09-28

    Treatment strategies for the management of antenatal depression are limited by varied and often modest response rates, unpleasant medication side effects and uncertainty regarding foetal safety. Consequently, many pregnant women experiencing depression seek alternative non-pharmaceutical options. Acupuncture may provide a safe and potentially effective additional treatment, however further investigation is required. In this qualitative study, we explored the views of health professionals regarding the possible incorporation of acupuncture into mainstream care. Two separate focus groups were run with 16 midwives. In-depth interviews were conducted with two maternity service managers and nine doctors (3 obstetricians, 2 psychiatrists and 4 general practitioners). Data was analysed using thematic analysis. Participants were generally positive about acupuncture and open to its possible inclusion in conventional care, on the proviso that it was safe and could be shown to be effective. The overarching theme to emerge was 'acupuncture for antenatal depression: it's worth giving it a go', which participants concluded after considering 'the dilemma of mental health' treatment during the antenatal period and the additional limitations this presented, along with the belief that 'if it doesn't do any harm, I'm not against it'. Practical considerations regarding potential 'barriers' and facilitators' to implementation were additionally explored in 'making it mainstream', whereby the different 'philosophical beliefs' held by participants were seen to influence perspectives. Participants expressed an overall positive attitude towards the possible inclusion of acupuncture into mainstream care for antenatal depression, suggesting various hospital barriers could be overcome with further safety and effectiveness evidence. Copyright © 2017 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  3. Formation of nanoporous pyrobitumen residues during maturation processes within the Barnett Shale (Fort Worth Basin)

    Science.gov (United States)

    Bernard, S.; Wirth, R.; Schreiber, A.; Schulz, H.-M.; Horsfield, B.

    2012-04-01

    Hydrocarbon generation processes occur within organic-rich shales as a response to increases in thermal maturation. Shale gas reservoir quality is thought to be largely dependent on the extent to which solid organic material has been converted to pore space during catagenesis. Although pores may drastically vary in variety and abundance within differing shales, the occurrence of nanopores within organic particles has recently been documented for an important number of gas shale systems (i.e., Barnett, Haynesville, Utica, Eagle Ford, Woodford, Horn River, Marcellus, Posidonia …). However, despite their ubiquitous nature, the formation and the geochemical nature of these nanoporous organic compounds remain unclear. Here, we present the characterization of samples from the organic-rich Mississippian Barnett shale gas system (Fort Worth Basin, Texas, USA) at varying stages of thermal maturation. Using a combination of compositional organic geochemistry and spectromicroscopy techniques, including synchrotron-based scanning transmission X-ray microscopy (STXM - data collected using the CLS 10ID-1 STXM beamline) and transmission electron microscopy (TEM), we document a net increase in sample geochemical heterogeneity with increasing maturity. In addition to the presence of bitumen in samples of oil window maturity, very likely genetically derived from thermally degraded kerogen, the formation of nanoporous pyrobitumen has been inferred for samples of gas window maturity, likely resulting from the formation of gaseous hydrocarbons by secondary cracking of bitumen compounds. By providing in-situ insights into the fate of bitumen and pyrobitumen as a response to the thermal evolution of the macromolecular structure of kerogen, the present contribution constitutes an important step towards better constraining hydrocarbon generation processes occurring within unconventional gas shale systems.

  4. First results from SAM-FP: Fabry-Perot observations with ground-layer adaptive optics - the structure and kinematics of the core of 30 Doradus

    Science.gov (United States)

    Mendes de Oliveira, C.; Amram, P.; Quint, Bruno C.; Torres-Flores, S.; Barbá, R.; Andrade, D.

    2017-08-01

    The aim of this paper is to present the first data set obtained with SOAR Adaptive Module-Fabry-Parot (SAM-FP), a Fabry-Perot instrument mounted inside the SOAR telescope Adaptive-Optics Module. This is the only existing imaging Fabry-Perot interferometer using laser-assisted ground-layer adaptive optics. SAM-FP was used to observe the ionized gas, traced by Hα, in the centre of the 30 Doradus starburst (the Tarantula Nebula) in the Large Magellanic Cloud, with high spatial (∼0.6 arcsec, or 0.15 pc) and spectral (R ≃ 11 200) resolution. Radial velocity, velocity dispersion and monochromatic maps were derived. The region displays a mix of narrow, σ ∼ 20 km s-1 profiles and multiple broader profiles with σ ∼ 70-80 km s-1, indicating the complex nature of the nebula kinematics. A comparison with previously obtained VLT/FLAMES spectroscopy demonstrates that the data agree well in the regions of overlap, but the Fabry-Perot data are superior in spatial coverage. A preliminary analysis of the observations finds a new expanding bubble south of R136, with a projected radius of r = 5.6 pc and an expansion velocity of 29 ± 4 km s-1. In addition, the first-time detailed kinematic maps derived here for several complexes and filaments of 30 Doradus allow identification of kinematically independent structures. These data exemplify the power of the combination of a high-order Fabry-Perot with a wide-field imager (3 × 3 arcmin2 GLAO-corrected field of view) for high-resolution spatial and spectral studies. In particular, SAM-FP data cubes are highly advantageous over multifibre or long-slit data sets for nebula structure studies and to search for small-scale bubbles, given their greatly improved spatial coverage. For reference, this paper also presents two appendices with detailed descriptions of the usage of Fabry-Perot devices, including formulae and explanations for understanding Fabry-Perot observations.

  5. Effect of long-term treatment with pramipexole or levodopa on presynaptic markers assessed by longitudinal [123I]FP-CIT SPECT and histochemistry.

    Science.gov (United States)

    Depboylu, Candan; Maurer, Lukas; Matusch, Andreas; Hermanns, Guido; Windolph, Andrea; Béhé, Martin; Oertel, Wolfgang H; Höglinger, Günter U

    2013-10-01

    A previous clinical trial studied the effect of long-term treatment with levodopa (LD) or the dopamine agonist pramipexole (PPX) on disease progression in Parkinson disease using SPECT with the dopamine transporter (DAT)-radioligand [(123)I]β-CIT as surrogate marker. [(123)I]β-CIT binding declined to significantly lower levels in patients receiving LD compared to PPX. However, the interpretation of this difference as LD-induced neurotoxicity, PPX-induced neuroprotection/-regeneration, or only drug-induced regulatory changes of DAT-availability remained controversial. To address this question experimentally, we induced a subtotal lesion of the substantia nigra in mice by bilateral injection of the neurotoxin 6-hydroxydopamine. After 4 weeks, mice were treated for 20 weeks orally with LD (100mg/kg/day) or PPX (3mg/kg/day), or water (vehicle) only. The integrity of nigrostriatal projections was assessed by repeated [(123)I]FP-CIT SPECT in vivo and by immunostaining for DAT and the dopamine-synthesizing enzyme tyrosine hydroxylase (TH) after sacrifice. In sham-lesioned mice, we found that both LD and PPX treatment significantly decreased the striatal FP-CIT binding (LD: -21%; PPX: -14%) and TH-immunoreactivity (LD: -42%; PPX: -45%), but increased DAT-immunoreactivity (LD: +42%; PPX: +33%) compared to controls without dopaminergic treatment. In 6-hydroxydopamine-lesioned mice, however, neither LD nor PPX significantly influenced the stably reduced FP-CIT SPECT signal (LD: -66%; PPX: -66%; controls -66%), TH-immunoreactivity (LD: -70%; PPX: -72%; controls: -77%) and DAT-immunoreactivity (LD: -70%; PPX: -75%; controls: -75%) in the striatum or the number of TH-positive cells in the substantia nigra (LD: -88%; PPX: -88%; controls: -86%), compared to lesioned mice without dopaminergic treatment. In conclusion, chronic dopaminergic stimulation with LD or PPX induced similar adaptive presynaptic changes in healthy mice, but no discernible changes in severely lesioned mice

  6. Friendship predictors of global self-worth and domain-specific self-concepts in university students with and without learning disability.

    Science.gov (United States)

    Shany, Michal; Wiener, Judith; Assido, Michal

    2013-01-01

    This study investigated the association among friendship, global self-worth, and domain-specific self-concepts in 102 university students with and without learning disabilities (LD). Students with LD reported lower global self-worth and academic self-concept than students without LD, and this difference was greater for women. Students with LD also reported that they had more stable friendships than students without LD. Students with LD were more likely to have higher global self-worth and self-perceptions of social acceptance if they had stable friendships and had relationships where they communicated spontaneously and frankly. None of the friendship variables predicted academic self-concept. Thus, having stable and intimate friendships is a protective factor in relation to global self-worth and social self-concept in university students with LD.

  7. Quality and clinical supply considerations of Paediatric Investigation Plans for IV preparations-A case study with the FP7 CloSed project.

    Science.gov (United States)

    Hanning, Sara M; Orlu Gul, Mine; Winslade, Jackie; Baarslag, Manuel A; Neubert, Antje; Tuleu, Catherine

    2016-09-25

    A Paediatric Investigation Plan (PIP) is a development plan that aims to ensure that sufficient data are obtained through studies in paediatrics to support the generation of marketing authorisation of medicines for children. This paper highlights some practical considerations and challenges with respect to PIP submissions and paediatric clinical trials during the pharmaceutical development phase, using the FP7-funded Clonidine for Sedation of Paediatric Patients in the Intensive Care Unit (CloSed) project as a case study. Examples discussed include challenges and considerations regarding formulation development, blinding and randomisation, product labelling and shipment and clinical trial requirements versus requirements for marketing authorisation. A significant quantity of information is required for PIP submissions and it is hoped that future applicants may benefit from an insight into some critical considerations and challenges faced in the CloSed project.

  8. Recent advances on green concrete for structural purposes the contribution of the EU-FP7 project EnCoRe

    CERN Document Server

    Ferrara, Liberato; Martinelli, Enzo

    2017-01-01

    This book is mainly based on the results of the EU-funded UE-FP7 Project EnCoRe, which aimed to characterize the key physical and mechanical properties of a novel class of advanced cement-based materials incorporating recycled powders and aggregates and/or natural ingredients in order to allow partial or even total replacement of conventional constituents. More specifically, the project objectives were to predict the physical and mechanical performance of concrete with recycled aggregates; to understand the potential contribution of recycled fibers as a dispersed reinforcement in concrete matrices; and to demonstrate the feasibility and possible applications of natural fibers as a reinforcement in cementitious composites. All of these aspects are fully covered in the book. The opening chapters explain the material concept and design and discuss the experimental characterization of the physical, chemical, and mechanical properties of the recycled raw constituents, as well as of the cementitious composite incor...

  9. Study on low tempurature demulsifier test for high water- content crude fluid%原油低温破乳剂FP330评价

    Institute of Scientific and Technical Information of China (English)

    宋军; 汪丽

    2007-01-01

    以大庆采油六厂原油为研究对象,考察了不同油水组成乳化油的粘温关系;对低温破乳剂FP330的破乳效果进行了评价,结果表明:40℃时,加入破乳剂的量占乳化油的体积比为80μg·g-1时,脱水效果较好.破乳剂有助于液滴并聚,破乳速率符合一级速率方程.

  10. Probiotic Streptococcus thermophilus FP4 and Bifidobacterium breve BR03 Supplementation Attenuates Performance and Range-of-Motion Decrements Following Muscle Damaging Exercise

    Directory of Open Access Journals (Sweden)

    Ralf Jäger

    2016-10-01

    Full Text Available Probiotics have immunomodulatory effects. However, little is known about the potential benefit of probiotics on the inflammation subsequent to strenuous exercise. In a double-blind, randomized, placebo controlled, crossover design separated by a 21-day washout, 15 healthy resistance-trained men ingested an encapsulated probiotic Streptococcus (S. thermophilus FP4 and Bifidobacterium (B. breve BR03 at 5 bn live cells (AFU concentration each, or a placebo, daily for 3 weeks prior to muscle-damaging exercise (ClinicalTrials.gov NCT02520583. Isometric strength, muscle soreness, range of motion and girth, and blood interleukin-6 (IL-6 and creatine kinase (CK concentrations were measured from pre- to 72 h post-exercise. Statistical analysis was via mixed models and magnitude-based inference to the standardized difference. Probiotic supplementation resulted in an overall decrease in circulating IL-6, which was sustained to 48 h post-exercise. In addition, probiotic supplementation likely enhanced isometric average peak torque production at 24 to 72 h into the recovery period following exercise (probiotic–placebo point effect ±90% CI: 24 h, 11% ± 7%; 48 h, 12% ± 18%; 72 h, 8% ± 8%. Probiotics also likely moderately increased resting arm angle at 24 h (2.4% ± 2.0% and 48 h (1.9% ± 1.9% following exercise, but effects on soreness and flexed arm angle and CK were unclear. These data suggest that dietary supplementation with probiotic strains S. thermophilus FP4 and B. breve BR03 attenuates performance decrements and muscle tension in the days following muscle-damaging exercise.

  11. Effect of fish oil on lateral mobility of prostaglandin F2α (FP) receptors and spatial distribution of lipid microdomains in bovine luteal cell plasma membrane in vitro.

    Science.gov (United States)

    Plewes, M R; Burns, P D; Graham, P E; Hyslop, R M; Barisas, B G

    2017-01-01

    Lipid microdomains are ordered regions on the plasma membrane of cells, rich in cholesterol and sphingolipids, ranging in size from 10 to 200 nm in diameter. These lipid-ordered domains may serve as platforms to facilitate colocalization of intracellular signaling proteins during agonist-induced signal transduction. It is hypothesized that fish oil will disrupt the lipid microdomains, increasing spatial distribution of these lipid-ordered domains and lateral mobility of the prostaglandin (PG) F2α (FP) receptors in bovine luteal cells. The objectives of this study were to examine the effects of fish oil on (1) the spatial distribution of lipid microdomains, (2) lateral mobility of FP receptors, and (3) lateral mobility of FP receptors in the presence of PGF2α on the plasma membrane of bovine luteal cells in vitro. Bovine ovaries were obtained from a local abattoir and corpora lutea were digested using collagenase. In experiment 1, lipid microdomains were labeled using cholera toxin subunit B Alexa Fluor 555. Domains were detected as distinct patches on the plasma membrane of mixed luteal cells. Fish oil treatment decreased fluorescent intensity in a dose-dependent manner (P oil treatment on lateral mobility of FP receptors. Fish oil treatment increased microdiffusion and macrodiffusion coefficients of FP receptors as compared to control cells (P oil-treated cells (P oil treatment. Lateral mobility of receptors was decreased within 5 min following the addition of ligand for control cells (P oil-treated cells (P > 0.10). The data presented provide strong evidence that fish oil causes a disruption in lipid microdomains and affects lateral mobility of FP receptors in the absence and presence of PGF2α.

  12. Is fear of others linked to an uncertain sense of self? The relevance of self-worth, interpersonal self-concepts, and dysfunctional beliefs to paranoia.

    Science.gov (United States)

    Lincoln, Tania M; Mehl, Stephanie; Ziegler, Michael; Kesting, Marie-Luise; Exner, Cornelia; Rief, Winfried

    2010-06-01

    The assumption that a low sense of self-worth can give rise to paranoid delusions is relevant from a therapeutic perspective, but research has been inconsistent. The present study sought to investigate how interpersonal self-concepts and global self-worth relate to psychotic and depressive psychopathology in persons with psychosis. Participants with psychosis (n=83) and healthy controls (n=33) were assessed for global self-worth, interpersonal self-concepts, and dysfunctional beliefs using the Frankfurt Self-Concept Scale and the Dysfunctional Attitude Scale. Symptoms were assessed with the Positive and Negative Syndrome Scale, the Peters et al. Delusions Inventory, the Paranoia Checklist, and the Beck Depression Inventory. We hypothesized that perceived threat to self-worth, as expressed in dysfunctional acceptance beliefs and negative interpersonal self-concepts, would be uniquely associated with persecutory delusions. In contrast, low global self-worth would be strongly associated with symptoms of depression. Multiple regression analyses were used to investigate the association between symptoms and self-concepts. As expected, low global self-worth was associated with depression, whereas the more specific perception of not being accepted by relevant others was most clearly related to psychotic symptoms. Almost half of the variance in paranoia scores was explained by negative interpersonal self-concepts and the interaction between negative interpersonal self-concepts and dysfunctional acceptance beliefs. Thus, cognitive interventions for delusions might be improved by focusing more on interpersonal self-concepts.

  13. Preparation of floating visible-light photocatalyst Fe-N-TiO2/FP-CTS and its application in degradation of dissolved diesel oil%漂浮型可见光催化剂Fe-N-TiO2/FP-CTS的制备及其对溶解性柴油的降解

    Institute of Scientific and Technical Information of China (English)

    黄嘉瑜; 王学江; 卜云洁; 张晶; 马荣荣; 赵建夫

    2015-01-01

    以漂珠为载体,用壳聚糖对漂珠进行改性,并采用溶胶凝胶法,制备了Fe-N共掺杂改性TiO2的漂浮型可见光催化剂(Fe-N-TiO2/FP-CTS),使用X射线衍射(XRD)、紫外可见分光光谱(UV-Vis)、N2吸附-脱附(BET)和扫描电子显微镜(SEM)等分析进行表征.研究结果表明,用壳聚糖改性漂珠可以增加复合光催化剂的比表面积和孔容;相较于N-掺杂TiO2/FP复合光催化剂,Fe-N共掺杂更能促进对复合光催化剂可见光的吸收;光催化4h后,Fe-N-TiO2/FP-CTS对溶解性柴油的降解率达到61.7%,明显优于Fe-N-TiO2/FP和N-TiO2/FP.当初始pH =5,柴油乳化剂浓度=120 mg/L时,复合光催化剂对溶解性柴油的光催化降解效果最佳.

  14. Isothiazolone Volatility Study of a Water Bottom from Fuel Treated with Kathon(trade name) FP1.5 Biocide

    Science.gov (United States)

    1993-11-01

    specific biocides was evaluated. Pure cultures of Hormonoconis resinae (previously Cladosporium resinae ), Yarrowia lipolytica and Pseudomonas...R.A., "Growth of Cladosporium resinae in Sea Water/Fuel Systems", Developments in Industrial Microbiology, 22, 781 (1981). 5 MacGregor C. and Devitt S...Contractor Report CR/87/431, (1987). 8 Hebda A.J. and Jones G.M., "Conditions and Modifications to Conditions for Growth of C. resinae in Canadian

  15. Shale depositional processes: Example from the Paleozoic Barnett Shale, Fort Worth Basin, Texas, USA

    Science.gov (United States)

    Abouelresh, Mohamed; Slatt, Roger

    2011-12-01

    A long held geologic paradigm is that mudrocks and shales are basically the product of `hemipelagic rain' of silt- and/or clay-sized, detrital, biogenic and particulate organic particles onto the ocean floor over long intervals of time. However, recently published experimental and field-based studies have revealed a plethora of micro-sedimentary features that indicate these common fine-grained rocks also could have been transported and/or reworked by unidirectional currents. In this paper, we add to this growing body of knowledge by describing such features from the Paleozoic Barnett Shale in the Fort Worth Basin, Texas, U.S.A. which suggests transport and deposition was from hyperpycnal, turbidity, storm and/or contour currents, in addition to hemipelagic rain. On the basis of a variety of sedimentary textures and structures, six main sedimentary facies have been defined from four 0.3 meter intervals in a 68m (223 ft) long Barnett Shale core: massive mudstone, rhythmic mudstone, ripple and low-angle laminated mudstone, graded mudstone, clay-rich facies, and spicule-rich facies. Current-induced features of these facies include mm- to cmscale cross- and parallel-laminations, scour surfaces, clastic/biogenic particle alignment, and normal- and inverse-size grading. A spectrum of vertical facies transitions and bed types indicate deposition from waxing-waning flows rather than from steady `rain' of particles to the sea floor. Detrital sponge spicule-rich facies suggests transport to the marine environment as hypopycnal or hyperpycnal flows and reversal in buoyancy by transformation from concentrated to dilute flows; alternatively the spicules could have originated by submarine slumping in front of contemporaneous shallow marine sponge reefs, and then transported basinward as turbidity current flows. The occurrence of dispersed biogenic/organic remains and inversely size graded mudstones also support a hyperpycnal and/or turbidity flow origin for a significant part of

  16. Treatment of APP/PS1 Double Transgenic Mice of Alzheimer ‘s Disease by Transplanting pEGFP/A2M (FP6) Transfected Neural Stem Cells into the Hippocampus%pEGFP/A2M(FP6)转染神经干细胞海马移植治疗APP/PS1双转基因AD小鼠的实验观察

    Institute of Scientific and Technical Information of China (English)

    武强; 廖光昊; 李露斯; 范文辉; 黎红华; 濮捷; 徐志鹏; 程鹤; 杨柳; 刘菲

    2013-01-01

    Objective: To observe the migration and differentiation of pEGFP/A2M (FP6) transfected neural stem cells (NSCs), the deposits of Aβ in the brain and the change of learning and memory ability of APP/PS1 double transgenic mice of Alzheimer's Disease (AD) after the NSCs were transplanted into the hippocampus. Methods: APP/PS1 transgenic AD mice were randomly divided into four groups: sham operated (SO) group, artificial cerebrospinal fluid (ACSF) group, transfected pEGFP neural stem cell (pEGFP-NSCs) group and transfected pEGFP/A2M(FP6) neural stem cell (pEGFP/A2M(FP6)-NSCs) group. The ACSF, pEGFP-NSCs or pEGFP/A2M (FP6)-NSCs were transplanted into the CA1 region of the hippocampus of the mice. The learning and memory ability of the mice were assessed with Mirror water maze test. The migration and differentiation of pEGFP/A2M(FP6) transfected NSCs and the deposits of Aβ in the brain of the mice were observed by immuno-histochemistry. Results: The latencies of pEGFP/A2M (FP6)-NSCs group and pEGFP-NSCs group were significantly shorter than that in the SO group and ASCF group (P<0.05). The latency of pEGFP/A2M(FP6)-NSCs group was shorter than that in the pEGFP-NSCs group (P<0.05). Anti-Aβ detection showed Aβ deposits in the hippocampus and cortex of pEGFP/A2M(FP6)-NSCs group and pEGFP-NSCs group were surrounded by transplanted NSCs. The amount and average size of Aβ deposits in the hippocampus and cortex of pEGFP/A2M (FP6)-NSCs group were reduced markedly, compared with the other three groups (P<0.05). The expression of Nestin was detecte after transplantation. Immunofluorescent detection indicated that majority of transplanted cells expressed GFAP while only a few cells expressed MAP-2. Conclusion: Transplantation of pEGFP/A2M (FP6)-NSCs into the hippocampal region of APP/PS1 double transgenic AD mice could reduce the Aβ deposits and promote the learning and memory ability. Partial transplanted NSCs will differentiate into neurons or astro

  17. Atmospheric Boundary Layer Wind Data During the Period January 1, 1998 Through January 31, 1999 at the Dallas-Fort Worth Airport. Volume 1; Quality Assessment

    Science.gov (United States)

    Zak, J. Allen; Rodgers, William G., Jr.

    2000-01-01

    The quality of the Aircraft Vortex Spacing System (AVOSS) is critically dependent on representative wind profiles in the atmospheric boundary layer. These winds observed from a number of sensor systems around the Dallas-Fort Worth airport were combined into single vertical wind profiles by an algorithm developed and implemented by MIT Lincoln Laboratory. This process, called the AVOSS Winds Analysis System (AWAS), is used by AVOSS for wake corridor predictions. During times when AWAS solutions were available, the quality of the resultant wind profiles and variance was judged from a series of plots combining all sensor observations and AWAS profiles during the period 1200 to 0400 UTC daily. First, input data was evaluated for continuity and consistency from criteria established. Next, the degree of agreement among all wind sensor systems was noted and cases of disagreement identified. Finally, the resultant AWAS solution was compared to the quality-assessed input data. When profiles differed by a specified amount from valid sensor consensus winds, times and altitudes were flagged. Volume one documents the process and quality of input sensor data. Volume two documents the data processing/sorting process and provides the resultant flagged files.

  18. Verification and uncertainty evaluation of HELIOS/MASTER nuclear design system

    Energy Technology Data Exchange (ETDEWEB)

    Song, Jae Seung; Kim, J. C.; Cho, B. O. [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-03-01

    A nuclear design system HELIOS/MASTER was established and core follow calculations were performed for Yonggwang Unit 1 cycles 1 through 7 and Yonggwang Unit 3 cycles 1 through 2. The accuracy of HELIOS/MASTER system was evaluated by estimations of uncertainties of reactivity and peaking factors and by comparisons of the maximum differences of isothermal temperature coefficient, inverse boron worth and control rod worth with the CASMO-3/MASTER uncertainties. The reactivity uncertainty was estimated by 362 pcm, and the uncertainties of three-dimensional, axially integrated radial, and planar peaking factors were evaluated by 0.048, 0.034, and 0.044 in relative power unit, respectively. The maximum differences of isothermal temperature coefficient, inverse boron worth and control rod worth were within the CASMO-3/MASTER uncertainties. 17 refs., 17 figs., 10 tabs. (Author)

  19. Fluorescence emission and polarization analyses for evaluating binding of ruthenium metalloglycoclusters to lectins and tetanus toxin C-fragment

    Science.gov (United States)

    Okada, Tomoko; Minoura, Norihiko

    2011-03-01

    We develop a fluorescent ruthenium metalloglycocluster for use as a powerful molecular probe in evaluating the binding between carbohydrates and lectins by fluorescence emission (FE) and fluorescence polarization (FP) analyses. Changes in the FE and FP of these metalloglycoclusters are measured following the addition of lectin [peanut agglutinin (PNA), Ricinus communis agglutinin 120, Concanavalin A (ConA), or wheat germ agglutinin] or tetanus toxin c-fragment (TCF). After the addition of PNA, the FE spectrum of [Ru(bpy-2Gal)3] shows a new emission peak and the FP value of [Ru(bpy-2Gal)3] increases. Similarly, the FE spectrum of [Ru(bpy-2Glc)3] shows a new emission peak and the FP value increases on addition of ConA. Because other combinations of metalloglycoclusters and lectins show little change, specific binding of galactose to PNA and that of glucose to ConA are confirmed by the FE and FP measurements. Resulting dissociation constants (Kd) prove that the metalloglycoclusters with highly clustered carbohydrates show higher affinity for the respective lectins than those with less clustered carbohydrates. Furthermore, specific binding of [Ru(bpy-2Gal)3] to TCF was confirmed by the FP measurement.

  20. Fluorescence emission and polarization analyses for evaluating binding of ruthenium metalloglycocluster to lectin and tetanus toxin c-fragment

    Science.gov (United States)

    Okada, Tomoko; Minoura, Norihiko

    2010-02-01

    We have developed a fluorescent ruthenium metalloglycocluster as a powerful molecular probe for evaluating a binding event between carbohydrates and lectins by fluorescence emission (FE) and fluorescence polarization (FP) analysis. The fluorescent ruthenium metalloglycoclusters, [Ru(bpy-2Gal)3] and [Ru(bpy-2Glc)3], possess clustered galactose and glucose surrounding the ruthenium center. Changes in FE and FP of these metalloglycoclusters were measured by adding each lectin (Peanut agglutinin (PNA), Ricinus communis agglutinin 120 (RCA), Concanavalin A (ConA), or Wheat germ agglutinin (WGA)) or tetanus toxin c-fragment (TCF). Following the addition of PNA, the FE spectrum of [Ru(bpy- 2Gal)3] showed new emission peak and the FP value of [Ru(bpy-2Gal)3] increased. Similarly, the FE spectrum of [Ru(bpy-2Glc)3] showed new emission peak and the FP value increased following the addition of ConA. Since other combinations of the metalloglycoclusters and lectin caused little change, specific bindings of galactose to PNA and glucose to ConA were proved by the FE and FP measurement. From nonlinear least-squares fitting, dissociation constants (Kd) of [Ru(bpy-2Gal)3] to PNA was 6.1 μM, while the Kd values of [Ru(bpy)2(bpy-2Gal)] to PNA was ca. 10-4 M. Therefore, the clustered carbohydrates were proved to increase affinity to lectins. Furthermore, the FP measurements proved specific binding of [Ru(bpy-2Gal)3] to TCF.