WorldWideScience

Sample records for founding early history

  1. F.M. Glenn Willson: Early UCSC History and the Founding of Stevenson College

    OpenAIRE

    Willson, F.M. Glenn; Jarrell, Randall; Regional History Project, UCSC Library

    1989-01-01

    Glenn Willson addresses campus developments from January 1965, when he joined the early faculty, until his resignation in 1975, when he returned home to England. During this period he held a number of campus appointments, including the provostship at Stevenson College from 1967 to 1975, and service as the chair of the Academic Senate; as Vice-Chancellor, College and Student Affairs; and as acting chair of the Theater Arts Committee. Willson focuses on three aspects of UCSC history in...

  2. A History of the Founding and Early Development of the "Journal of School Psychology"

    Science.gov (United States)

    Fagan, Thomas K.; Jack, Sabrina L.

    2012-01-01

    Historical aspects of the founding and early development of the "Journal of School Psychology" are discussed. Emphases are placed on the first decade of the journal, the factors in its founding and development, persons who have served as editors and members of the editorial boards and corporate leadership, and the journal's changing formats. The…

  3. A history of the founding and early development of the Journal of School Psychology.

    Science.gov (United States)

    Fagan, Thomas K; Jack, Sabrina L

    2012-12-01

    Historical aspects of the founding and early development of the Journal of School Psychology are discussed. Emphases are placed on the first decade of the journal, the factors in its founding and development, persons who have served as editors and members of the editorial boards and corporate leadership, and the journal's changing formats. The publication's relationships to the Journal of School Psychology, Inc. and later to the Society for the Study of School Psychology are briefly mentioned. Copyright © 2012 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

  4. Personality over Policy: A Comparative History of the Founding and Early Development of Four Significant American Manuscript Repositories of Business, Industry, and Technology

    Science.gov (United States)

    Nordberg, Erik C.

    2017-01-01

    This dissertation compares and contrasts the founding and early manuscript collecting activities of four publicly accessible American archival repositories known for their extensive holdings in business, industrial, and technological history: the Baker Library at Harvard University in Boston, Massachusetts; the Hagley Library and Museum in…

  5. Mercury's Early Geologic History

    Science.gov (United States)

    Denevi, B. W.; Ernst, C. M.; Klima, R. L.; Robinson, M. S.

    2018-05-01

    A combination of geologic mapping, compositional information, and geochemical models are providing a better understanding of Mercury's early geologic history, and allow us to place it in the context of the Moon and the terrestrial planets.

  6. CERN's Early History Revisited

    CERN Multimedia

    Schopper, Herwig Franz; Krige, Gerhard John

    2005-01-01

    As a member of the group of historians charged to write the history of the founding of CERN, John Krige particularly underlines the important role I.I. Rabi played. The first author, former Director General of CERN add a few comments. S.A. Khan gives precisions about the role played by E. Amaldi and P. Auger; then J. Krige replies

  7. History of early atomic clocks

    International Nuclear Information System (INIS)

    Ramsey, N.F.

    2005-01-01

    This review of the history of early atomic clocks includes early atomic beam magnetic resonance, methods of separated and successive oscillatory fields, microwave absorption, optical pumping and atomic masers. (author)

  8. Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes.

    Science.gov (United States)

    Harduin-Lepers, Anne; Petit, Daniel; Mollicone, Rosella; Delannoy, Philippe; Petit, Jean-Michel; Oriol, Rafael

    2008-09-23

    The animal sialyltransferases, which catalyze the transfer of sialic acid to the glycan moiety of glycoconjugates, are subdivided into four families: ST3Gal, ST6Gal, ST6GalNAc and ST8Sia, based on acceptor sugar specificity and glycosidic linkage formed. Despite low overall sequence identity between each sialyltransferase family, all sialyltransferases share four conserved peptide motifs (L, S, III and VS) that serve as hallmarks for the identification of the sialyltransferases. Currently, twenty subfamilies have been described in mammals and birds. Examples of the four sialyltransferase families have also been found in invertebrates. Focusing on the ST8Sia family, we investigated the origin of the three groups of alpha2,8-sialyltransferases demonstrated in vertebrates to carry out poly-, oligo- and mono-alpha2,8-sialylation. We identified in the genome of invertebrate deuterostomes, orthologs to the common ancestor for each of the three vertebrate ST8Sia groups and a set of novel genes named ST8Sia EX, not found in vertebrates. All these ST8Sia sequences share a new conserved family-motif, named "C-term" that is involved in protein folding, via an intramolecular disulfide bridge. Interestingly, sequences from Branchiostoma floridae orthologous to the common ancestor of polysialyltransferases possess a polysialyltransferase domain (PSTD) and those orthologous to the common ancestor of oligosialyltransferases possess a new ST8Sia III-specific motif similar to the PSTD. In osteichthyans, we have identified two new subfamilies. In addition, we describe the expression profile of ST8Sia genes in Danio rerio. Polysialylation appeared early in the deuterostome lineage. The recent release of several deuterostome genome databases and paralogons combined with synteny analysis allowed us to obtain insight into events at the gene level that led to the diversification of the ST8Sia genes, with their corresponding enzymatic activities, in both invertebrates and vertebrates. The

  9. Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia gene family: Tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes

    Directory of Open Access Journals (Sweden)

    Petit Jean-Michel

    2008-09-01

    Full Text Available Abstract Background The animal sialyltransferases, which catalyze the transfer of sialic acid to the glycan moiety of glycoconjugates, are subdivided into four families: ST3Gal, ST6Gal, ST6GalNAc and ST8Sia, based on acceptor sugar specificity and glycosidic linkage formed. Despite low overall sequence identity between each sialyltransferase family, all sialyltransferases share four conserved peptide motifs (L, S, III and VS that serve as hallmarks for the identification of the sialyltransferases. Currently, twenty subfamilies have been described in mammals and birds. Examples of the four sialyltransferase families have also been found in invertebrates. Focusing on the ST8Sia family, we investigated the origin of the three groups of α2,8-sialyltransferases demonstrated in vertebrates to carry out poly-, oligo- and mono-α2,8-sialylation. Results We identified in the genome of invertebrate deuterostomes, orthologs to the common ancestor for each of the three vertebrate ST8Sia groups and a set of novel genes named ST8Sia EX, not found in vertebrates. All these ST8Sia sequences share a new conserved family-motif, named "C-term" that is involved in protein folding, via an intramolecular disulfide bridge. Interestingly, sequences from Branchiostoma floridae orthologous to the common ancestor of polysialyltransferases possess a polysialyltransferase domain (PSTD and those orthologous to the common ancestor of oligosialyltransferases possess a new ST8Sia III-specific motif similar to the PSTD. In osteichthyans, we have identified two new subfamilies. In addition, we describe the expression profile of ST8Sia genes in Danio rerio. Conclusion Polysialylation appeared early in the deuterostome lineage. The recent release of several deuterostome genome databases and paralogons combined with synteny analysis allowed us to obtain insight into events at the gene level that led to the diversification of the ST8Sia genes, with their corresponding enzymatic

  10. The Early History of Life

    Science.gov (United States)

    Nisbet, E. G.; Fowler, C. M. R.

    2003-12-01

    ago, for the most part the planet was peaceful. Even the most active volcanoes are mostly quiet; meteorites large enough to extinguish all dinosaurs may have hit as often as every few thousand years, but this is not enough to be a nuisance to a bacterium (except when the impact boiled the ocean); while to the photosynthesizer long-term shifts in the solar spectrum may be less of a problem than cloudy hazy days. Though, admittedly, green is junk light to biology, the excretion from the photosynthetic antennae, nevertheless even a green sky would have had other wavelengths also in its spectrum.Most important of all, like all good houses, this planet had location: Earth was just in the right spot. Not too far from the faint young Sun (Sagan and Chyba, 1997), it was also far enough away still to be in the comfort zone ( Kasting et al., 1993) when the mature Sun brightened. As many have pointed out, when Goldilocks arrived, she found everything just right. But what is less obvious is that as she grew and changed, and the room changed too, she commenced to rearrange the furniture to make it ever righter for her. Thus far, the bears have not arrived, though they may have reclaimed Mars from Goldilocks's sister see ( Figure 1). (3K)Figure 1. The habitable zone (Kasting et al., 1993). Too close to the Sun, a planet's surface is too hot to be habitable; too far, it is too cold. Early in the history of the solar system, the Sun was faint and the habitable zone was relatively close; 4.5 Ga later, with a brighter Sun, planets formerly habitable are now too hot, and the habitable zone has shifted out. Note that boundaries can shift. By changing its albedo and by altering the greenhouse gas content of the air, the planet can significantly widen the bounds of the habitable zone (Lovelock, 1979, 1988).

  11. Possible Analog for Early Solar System Disk Found

    Science.gov (United States)

    1998-10-01

    SOCORRO, NM -- The smallest protoplanetary disk ever seen rotating around a young star has been detected by an international team of astronomers using the National Science Foundation's Very Large Array (VLA) radio telescope. If confirmed, this result could provide an "ideal laboratory" for studying potential planet-forming disks of a size similar to the one that formed our Solar System. The researchers used the VLA to image the core of an object known as NGC 2071, some 1300 light years from Earth. The team of astronomers was able to measure the rotation of a disk seen around a young star by tracking water masers - clusters of super-heated molecules that amplify radio emission -- within it. This is the first direct evidence of such motion in a protoplanetary disk. "This result is exciting because only through understanding protoplanetary disks can scientists answer the question of how easy - or hard - it is to create planets," said Jose M. Torrelles of the Institute for Astrophysics of Andalucia in Granada, Spain, leader of the research team. "Other protoplanetary disks have been found, but the system in NGC 2071 is the first that may be comparable to the disk that created our own Solar System. Its size is similar to the orbit of the planet Neptune around our Sun." "Because there is very little matter in one of these protoplanetary disks -- typically less than one hundredth the mass of our Sun -- they are extremely difficult to detect and study" said Paul Ho of the Harvard-Smithsonian Center for Astrophysics and another team member. "We needed the highest possible resolution of the VLA to do this work." The VLA is an array of twenty-seven radio dishes, each 25 meters in diameter, located outside of Socorro. The individual antennas can be moved along tracks to change the array's alignment. The work on NGC 2071 was done when the array was stretched out to over 36 kilometers, thus providing the extremely high resolution necessary to image the system. This disk

  12. The archive effect found footage and the audiovisual experience of history

    CERN Document Server

    Baron, Jaimie

    2013-01-01

    The Archive Effect: Found Footage and the Audiovisual Experience of History examines the problems of representation inherent in the appropriation of archival film and video footage for historical purposes. Baron analyses the way in which the meanings of archival documents are modified when they are placed in new texts and contexts, constructing the viewer's experience of and relationship to the past they portray. Rethinking the notion of the archival document in terms of its reception and the spectatorial experiences it generates, she explores the 'archive effect' as it is produced across the genres of documentary, mockumentary, experimental, and fiction films. This engaging work discusses how, for better or for worse, the archive effect is mobilized to create new histories, alternative histories, and misreadings of history. The book covers a multitude of contemporary cultural artefacts including fiction films like Zelig, Forrest Gump and JFK, mockumentaries such as The Blair Witch Project and Forgotten Silve...

  13. Early Childhood Education: History, Theory, and Practice

    Science.gov (United States)

    Morgan, Harry

    2006-01-01

    In this book, the author covers the history, theory, and practices that influence early childhood education along with an emphasis on infant and toddler care and education. He also presents a comparison of the conflict between education planners who support early childhood studies and state school systems whose cost-saving measures are dismantling…

  14. Early history of military radiology

    International Nuclear Information System (INIS)

    Eisenberg, R.L.

    1991-01-01

    This paper reports that soon after Roentgen's discovery, physicians in the armed services of the major powers grasped the importance of x-ray sin military surgery. By May of 1896, radiographic examinations were being performed on Italian soldiers returning from the ill-fated Ethiopian campaign. Initially, radiographs were used for foreign body localization and the detection of fractures; later, a full range of diagnostic services was offered. The early challenges of obtaining x-ray examinations in the field - fragility of tubes and plates, mobility of machines and patients, and unpredictability of radiation dosage - became the basis for innovations that would fundamentally alter the daily practice of radiology in civilian life

  15. Visual pathway abnormalities were found in most multiple sclerosis patients despite history of previous optic neuritis

    Directory of Open Access Journals (Sweden)

    Stella Maris Costa Castro

    2013-07-01

    Full Text Available Objective It was to investigate visual field (VF abnormalities in a group of multiple sclerosis (MS patients in the remission phase and the presence of magnetic resonance imaging (MRI lesions in the optic radiations. Methods VF was assessed in 60 participants (age range 20-51 years: 35 relapsing-remitting MS patients [20 optic neuritis (+, 15 optic neuritis (-] and 25 controls. MRI (3-Tesla was obtained in all patients. Results Visual parameters were abnormal in MS patients as compared to controls. The majority of VF defects were diffuse. All patients except one had posterior visual pathways lesions. No significant difference in lesion number, length and distribution was noted between patients with and without history of optic neuritis. One patient presented homonymous hemianopsia. Conclusion Posterior visual pathway abnormalities were found in most MS patients despite history of previous optic neuritis.

  16. Early history of physics with accelerators

    International Nuclear Information System (INIS)

    Anderson, H.L.

    1982-01-01

    The early history of physics at accelerators is reviewed, with emphasis on three experiments which have had a profound influence on our veiw of the structure of matter: The Franck and Hertz experiment opening practical ways of studying nuclear disintegration, and the discovery of the del ++ isobar of the proton by Fermi and collaborators, revealing structure in the nucleon. Fermi's work is illustrated by pages from his notebooks

  17. Early history of IVF in Australia

    Directory of Open Access Journals (Sweden)

    Kristina Janežič

    2014-08-01

    Full Text Available Background: The 1970s and 1980s represent the early era of in vitro fertilization (IVF research. This article is a concise review of the early history of IVF, focusing on the contributions made by Australian pioneers.Objectives: To research the history of the early days of IVF in Australia.Search Strategy: ‘IVF history’ was used as a search criteria in PubMed.Selection criteria: We selected articles that were dealing with Australian research on IVF in 1970–1980s and were also statistically sound where applicable.Data collection and analysis: We collected, processed, and analyzed the data, and summed up two decades of IVF research in Australia.Main results: The first ideas about introducing IVF research in Australia started in 1970. Years of trials and hard work bore success and the first baby was born in 1980. IVF procedures then spread quickly across Australia.Conclusions: Australia was a leading force in the early days of IVF and with many innovative approaches contributed greatly to the development of IVF as we know it today.

  18. Music as therapy in early history.

    Science.gov (United States)

    Thaut, Michael H

    2015-01-01

    The notion of music as therapy is based on ancient cross-cultural beliefs that music can have a "healing" effect on mind and body. Explanations for the therapeutic mechanisms in music have almost always included cultural and social science-based causalities about the uses and functions of music in society. However, it is also important to note that the view of music as "therapy" was also always strongly influenced by the view and understanding of the concepts and causes of disease. Magical/mystical concepts of illness and "rational" medicine probably lived side by side for thousands of years. Not until the late-nineteenth and early-twentieth centuries were the scientific foundations of medicine established, which allowed the foundations of music in therapy to progress from no science to soft science and most recently to actual brain science. Evidence for "early music therapy" will be discussed in four broad historical-cultural divisions: preliterate cultures; early civilizations in Mesopotamia, Egypt, Israel; Greek Antiquity; Middle Ages, Renaissance, and Baroque. In reviewing "early music therapy" practice, from mostly unknown periods of early history (using preliterate cultures as a window) to increasingly better documented times, including preserved notation samples of actual "healing" music, five theories and applications of early music therapy can be differentiated. © 2015 Elsevier B.V. All rights reserved.

  19. L'annee psychologique: history of the founding of a 100-year-old.

    Science.gov (United States)

    Nicolas, S; Segui, J; Ferrand, L

    2000-02-01

    The authors present the history of the founding of the French journal L'Annee Psychologique. The names of Theodule Ribot (1839-1916), Henry Beaunis (1830-1921), and Alfred Binet (1857-1911) are closely associated with the journal. Ribot's election to the chair of Experimental and Comparative Psychology at the College de France in 1888 marked the official emancipation of psychology in France. Because there was no laboratory associated with the chair, Beaunis, a physiological psychologist from Nancy, proposed to Ribot the creation of the first French laboratory of experimental psychology (1889). Under Beaunis's direction, this laboratory was established at the Sorbonne in Paris but was in fact dependent on another educational institution, L'Ecole Pratique des Hautes Etudes. In 1893 the laboratory's research was first published in a yearly journal named Travaux du Laboratoire de Psychologie Physiologique (2 volumes: 1893-1894). Binet, who joined the laboratory in 1891, was not satisfied by the form of this publication. With Beaunis's agreement, he then created L'Annee Psychologique in 1894 to develop the reputation of the laboratory's research. The authors present the evolution and vicissitudes of the journal from 1895 to 1912, with a glance up to the present.

  20. William C. Bagley and the Founding of Essentialism: An Untold Story in American Educational History

    Science.gov (United States)

    Null, J. Wesley

    2007-01-01

    Background/Context: Most people who study the history and philosophy of education have heard of essentialism, but few people know the story behind how, when, and why the movement came to exist. This paper tells this story for the first time. Purpose/Conclusions: This essay has three purposes. First, it provides an introduction to the life and…

  1. EARLY HISTORY OF GEOMETRIC PROBABILITY AND STEREOLOGY

    Directory of Open Access Journals (Sweden)

    Magdalena Hykšová

    2012-03-01

    Full Text Available The paper provides an account of the history of geometric probability and stereology from the time of Newton to the early 20th century. It depicts the development of two parallel ways: on one hand, the theory of geometric probability was formed with minor attention paid to other applications than those concerning spatial chance games. On the other hand, practical rules of the estimation of area or volume fraction and other characteristics, easily deducible from geometric probability theory, were proposed without the knowledge of this branch. A special attention is paid to the paper of J.-É. Barbier published in 1860, which contained the fundamental stereological formulas, but remained almost unnoticed both by mathematicians and practicians.

  2. Learning History in Early Childhood: Teaching Methods and Children's Understanding

    Science.gov (United States)

    Skjaeveland, Yngve

    2017-01-01

    This article discusses the teaching of history in early childhood education and care centres and children's understanding of history. Based on interviews with eight Norwegian early childhood education and care teachers and on interpretative phenomenological analysis, the article shows how the early childhood education and care centres teach…

  3. The curious history of relativity how Einstein's theory of gravity was lost and found again

    CERN Document Server

    Eisenstaedt, Jean

    2006-01-01

    Black holes may obliterate most things that come near them, but they saved the theory of general relativity. Einstein's theory was quickly accepted as the true theory of gravity after its publication in 1915, but soon took a back seat in physics to quantum mechanics and languished for decades on the blackboards of mathematicians. Not until the existence of black holes by Stephen Hawking and Roger Penrose in the 1960s, after Einstein's death, was the theory revived. Almost one hundred years after general relativity replaced Newton's theory of gravitation, The Curious History of Relativity tells the story of both events surrounding general relativity and the techniques employed by Einstein and the relativists to construct, develop, and understand his almost impenetrable theory. Jean Eisenstaedt, one of the world's leading experts on the subject, also discusses the theory's place in the evolution of twentieth-century physics. He describes the main stages in the development of general relativity: its beginnings,...

  4. Genomic identification of founding haplotypes reveals the history of the selfing species Capsella rubella.

    Directory of Open Access Journals (Sweden)

    Yaniv Brandvain

    Full Text Available The shift from outcrossing to self-fertilization is among the most common evolutionary transitions in flowering plants. Until recently, however, a genome-wide view of this transition has been obscured by both a dearth of appropriate data and the lack of appropriate population genomic methods to interpret such data. Here, we present a novel population genomic analysis detailing the origin of the selfing species, Capsella rubella, which recently split from its outcrossing sister, Capsella grandiflora. Due to the recency of the split, much of the variation within C. rubella is also found within C. grandiflora. We can therefore identify genomic regions where two C. rubella individuals have inherited the same or different segments of ancestral diversity (i.e. founding haplotypes present in C. rubella's founder(s. Based on this analysis, we show that C. rubella was founded by multiple individuals drawn from a diverse ancestral population closely related to extant C. grandiflora, that drift and selection have rapidly homogenized most of this ancestral variation since C. rubella's founding, and that little novel variation has accumulated within this time. Despite the extensive loss of ancestral variation, the approximately 25% of the genome for which two C. rubella individuals have inherited different founding haplotypes makes up roughly 90% of the genetic variation between them. To extend these findings, we develop a coalescent model that utilizes the inferred frequency of founding haplotypes and variation within founding haplotypes to estimate that C. rubella was founded by a potentially large number of individuals between 50 and 100 kya, and has subsequently experienced a twenty-fold reduction in its effective population size. As population genomic data from an increasing number of outcrossing/selfing pairs are generated, analyses like the one developed here will facilitate a fine-scaled view of the evolutionary and demographic impact of the

  5. History of electromyography and nerve conduction studies: A tribute to the founding fathers.

    Science.gov (United States)

    Kazamel, Mohamed; Warren, Paula Province

    2017-09-01

    The early development of nerve conduction studies (NCS) and electromyography (EMG) was linked to the discovery of electricity. This relationship had been concluded by observing the effect of applying electricity to the body of an animal and discovering that nerves and muscles themselves could produce electricity. We attempt to review the historical evolution of NCS and EMG over the last three centuries by reviewing the landmark publications of Galvani, Adrian, Denny-Brown, Larrabee, and Lambert. In 1771, Galvani showed that electrical stimulation of animal muscle tissue produced contraction and, thereby, the concept of animal electricity was born. In 1929, Adrian devised a method to record a single motor unit potential by connecting concentric needle electrodes to an amplifier and a loud speaker. In 1938, Denny-Brown described the fasciculation potentials and separated them from fibrillations. Toward the end of World War II, Larrabee began measuring the compound muscle action potential in healthy and injured nerves of war victims. In 1957, Lambert and Eaton described the electrophysiologic features of a new myasthenic syndrome associated with lung carcinoma. Overall, research on this topic was previously undertaken by neurophysiologists and then later by neurologists, with Adrian most likely being the first neurologist to be involved. The field greatly benefited from the invention of equipment that was capable of amplifying small bioelectrical currents by the beginning of the 20th century. Significant scientific and technical advances were later made during and after World War II which provided a large patient population with nerve injuries to study. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Gore vidal's early Hollywood: history, fiction and film Gore vidal's early Hollywood: history, fiction and film

    Directory of Open Access Journals (Sweden)

    Thomas LaBorie Burns

    2008-04-01

    Full Text Available Although Gore Vidal has both worked as a Hollywood screenwriter and written criticism on Film—in this regard, he is perhaps best known for a sustained attack on the auteur theory of the magisterial director—I am concerned in this paper mainly with his fiction account of the early days of film-making in his novel Hollywood (1990 and the relation of film to national political life depicted therein. This novel is the sixth in a series that gives a more or less continuous historical picture of the social and political history of the US from colonial times to the present. “Political” for Vidal, however, means primarily the acts of statesmen, diplomats, and high-ranking military personnel, and the social history he presents is that of the upper-class which supplies their ranks, so that what Vidal is in fact offering in these six novels is what one might call the history of the American “movers-and-shakers”. Although Gore Vidal has both worked as a Hollywood screenwriter and written criticism on Film—in this regard, he is perhaps best known for a sustained attack on the auteur theory of the magisterial director—I am concerned in this paper mainly with his fiction account of the early days of film-making in his novel Hollywood (1990 and the relation of film to national political life depicted therein. This novel is the sixth in a series that gives a more or less continuous historical picture of the social and political history of the US from colonial times to the present. “Political” for Vidal, however, means primarily the acts of statesmen, diplomats, and high-ranking military personnel, and the social history he presents is that of the upper-class which supplies their ranks, so that what Vidal is in fact offering in these six novels is what one might call the history of the American “movers-and-shakers”.

  7. Hydra II: A Faint and Compact Milky Way Dwarf Galaxy Found in the Survey of the Magellanic Stellar History

    NARCIS (Netherlands)

    Martin, Nicolas F.; Nidever, David L.; Besla, Gurtina; Olsen, Knut; Walker, Alistair R.; Vivas, A. Katherina; Gruendl, Robert A.; Kaleida, Catherine C.; Muñoz, Ricardo R.; Blum, Robert D.; Saha, Abhijit; Conn, Blair C.; Bell, Eric F.; Chu, You-Hua; Cioni, Maria-Rosa L.; de Boer, Thomas J. L.; Gallart, Carme; Jin, Shoko; Kunder, Andrea; Majewski, Steven R.; Martinez-Delgado, David; Monachesi, Antonela; Monelli, Matteo; Monteagudo, Lara; Noël, Noelia E. D.; Olszewski, Edward W.; Stringfellow, Guy S.; van der Marel, Roeland P.; Zaritsky, Dennis

    We present the discovery of a new dwarf galaxy, Hydra II, found serendipitously within the data from the ongoing Survey of the Magellanic Stellar History conducted with the Dark Energy Camera on the Blanco 4 m Telescope. The new satellite is compact ({{r}h}=68 ± 11 pc) and faint ({{M}V}=-4.8 ± 0.3),

  8. The Hanford Site: An anthology of early histories

    International Nuclear Information System (INIS)

    Gerber, M.S.

    1993-10-01

    This report discusses the following topics: Memories of War: Pearl Harbor and the Genesis of the Hanford Site; safety has always been promoted at the Hanford Site; women have an important place in Hanford Site history; the boom and bust cycle: A 50-year historical overview of the economic impacts of Hanford Site Operations on the Tri-Cities, Washington; Hanford's early reactors were crucial to the sites's history; T-Plant made chemical engineering history; the UO 3 plant has a long history of service. PUREX Plant: the Hanford Site's Historic Workhorse. PUREX Plant Waste Management was a complex challenge; and early Hanford Site codes and jargon

  9. Early modern natural history: Contributions from the Americas

    Indian Academy of Sciences (India)

    Early modern natural history: Contributions from the Americas and India. Rajesh Kochhar. Perspectives Volume 37 Issue ... Keywords. India; medical botany; natural history; scientific botany; the Americas. Author Affiliations. Rajesh Kochhar1. Indian Institute of Science Education and Research, Mohali 140 306 Punjab, India ...

  10. Dinetah: An Early History of the Navajo People.

    Science.gov (United States)

    Sundberg, Lawrence D.

    Originally written for Navajo elementary school students, this book chronicles the history of the Navajo people from prehistory to 1868. The book presents a sympathetic history of a people who depended on their tenacity and creative adaptability to survive troubled times. Chapters examine how Navajo culture changed from that of an early hunting…

  11. Early history of NMR at Los Alamos

    International Nuclear Information System (INIS)

    Jackson, J.A.

    1985-11-01

    Nuclear magnetic resonance (NMR) spectroscopy has developed into an important research tool in chemistry. More recently, NMR imaging and in vivo spectroscopy promise to produce a revolution in medicine and biochemistry. Early experiments at Los Alamos led to DOE programs involving stable isotopes of importance to biology and to medicine. These events are briefly recounted. 2 refs

  12. Early British synchrotrons, an informal history

    International Nuclear Information System (INIS)

    Lawson, J.D.

    1997-02-01

    An historical account of the design and construction of early synchrotrons in the United Kingdom, based partly on personal reminiscences, is presented. Material is also drawn from archives at Birmingham and CERN. The document covers the period from plans for the world's first synchrotron at Malvern after the Second World War to work done at Harwell Laboratory for CERN in the period 1951-1953. (UK)

  13. Hydra II: A Faint and Compact Milky Way Dwarf Galaxy Found in the Survey of the Magellanic Stellar History

    OpenAIRE

    Martin, NF; Nidever, DL; Besla, G; Olsen, K; Walker, AR; Vivas, AK; Gruendl, RA; Kaleida, CC; Muñoz, RR; Blum, RD; Saha, A; Conn, BC; Bell, EF; Chu, YH; Cioni, MRL

    2015-01-01

    © 2015. The American Astronomical Society. All rights reserved.We present the discovery of a new dwarf galaxy, Hydra II, found serendipitously within the data from the ongoing Survey of the Magellanic Stellar History conducted with the Dark Energy Camera on the Blanco 4 m Telescope. The new satellite is compact (rh = 68 ± 11 pc) and faint (MV = -4.8 ± 0.3), but well within the realm of dwarf galaxies. The stellar distribution of Hydra II in the color-magnitude diagram is well-described by a m...

  14. Strong family history and early onset of schizophrenia: about 2 ...

    African Journals Online (AJOL)

    Schizophrenia is a highly heritable psychotic disorder and high genetic loading is associated with early onset of the disease. The outcome of schizophrenia has also been linked with the age of onset as well as the presence of family history of the disease. Therefore families with patients with early onset Schizophrenia are ...

  15. Early Childhood Education: History, Theory, and Practice. Second Edition

    Science.gov (United States)

    Morgan, Harry

    2010-01-01

    Harry Morgan lays the foundations of what early childhood education is by integrating the history of the field with the philosophy and theories behind this discipline. From birth to age eight, when children become integrated into society through their education at school and at home, "Early Childhood Education" examines the education of this age…

  16. Haven't We Found Out All We Can about Children's Early Number?

    Science.gov (United States)

    Foster, Robin

    1998-01-01

    Indicates that there has been a lot of work done and that a great deal needs to be done in the future to explore the world of children's early number. Discusses the counting, the use of algorithm, practical mathematics, the use of manipulatives, individual differences and pedagogical concerns, and classroom applications. Contains 18 references.…

  17. Two different BRCA2 mutations found in a multigenerational family with a history of breast, prostate, and lung cancers

    Directory of Open Access Journals (Sweden)

    Caporale DA

    2014-06-01

    Full Text Available Diane A Caporale, Erica E SwensonDepartment of Biology, University of Wisconsin – Stevens Point, Stevens Point, WI, USAAbstract: Breast and lung cancer are two of the most common malignancies in the United States, causing approximately 40,000 and 160,000 deaths each year, respectively. Over 80% of hereditary breast cancer cases are due to mutations in two breast cancer predisposition genes, BRCA1 and BRCA2. These are tumor-suppressor genes associated with DNA repair. Since the discovery of these two genes in the mid-1990s, several other breast cancer predisposition genes have been identified, such as the CHEK2 gene encoding a regulator of BRCA1. Recently, studies have begun investigating the roles of BRCA1 and BRCA2 gene expression in lung cancer. We conducted a family-based case study that included a bloodline of Italian heritage with several cases of breast cancer and associated cancers (prostate and stomach through multiple generations and on a nonblood relative of Scottish/Irish descent who was consecutively diagnosed with breast and lung cancer. Cancer history and environmental risk factors were recorded for each family member. To investigate possible genetic risks, we screened for mutations in specific hypervariable regions of the BRCA1, BRCA2, and CHEK2 genes. DNA was extracted and isolated from the individuals' hair follicles and cheek cells. Polymerase chain reaction (PCR, allele-specific PCR, and DNA sequencing were performed to identify and verify the presence or absence of mutations in these regions. Genotypes of several family members were determined and carriers of mutations were identified. Here we report for the first time the occurrence of two different BRCA2 frameshift mutations within the same family. Specifically, three Italian family members were found to be carriers of the BRCA2-c.2808_2811delACAA (3036delACAA mutation, a 4-nucleotide deletion in exon 11, which is a truncated mutation that causes deleterious function of

  18. Birth and early history of nuclear power

    International Nuclear Information System (INIS)

    Kenton, J.E.

    1978-01-01

    The history of nuclear generation of electric power is traced from Sir Ernest Rutherford's first pessimistic assessment in 1933 to the present time, when 12% of U.S. electricity comes from nuclear plants. The U.S. Navy is credited with being the first to see the potential for nuclear power reactors for submarine propulsion. The author relates the story of the Manhattan Engineering District during World War II and traces the nuclear submarine development as it paralleled postwar civilian power programs from the first light water reactors to the present controversy over the breeder reactor. The momentum of technology development is seen to have slowed, possibly because the 1955 success of the USS Nautilus prompted world acceptance of the LWR as the dominant power reactor

  19. Parental death and bipolar disorder: a robust association was found in early maternal suicide

    DEFF Research Database (Denmark)

    Tsuchiya, Kenji; Agerbo, Esben; Mortensen, Preben Bo

    2005-01-01

    of a conditional logistic regression analysis. RESULTS: Among 947 subjects with bipolar disorder and 47,350 controls, those having experienced the parental suicide were significantly associated with an increased risk for BPD (incidence rate ratios: 1.83 [95% confidence interval: 1.07 to 3.12] for paternal suicide......BACKGROUND: Previous studies have suggested that early parental death may be associated with the emergence of bipolar disorder in later life. However, it remains unknown whether this association applies specifically to parental death due to suicide or only to early parental death. The present study...... were born in 1960 or later and were first admitted to or had first contact with Danish psychiatric facilities between 1981 and 1998 with a diagnosis of bipolar disorder, and fifty age-matched controls per case were extracted. The effects of the deaths of relatives were estimated by means...

  20. Early history of the concept of autogynephilia.

    Science.gov (United States)

    Blanchard, Ray

    2005-08-01

    Since the beginning of the last century, clinical observers have described the propensity of certain males to be erotically aroused by the thought or image of themselves as women. Because there was no specific term to denote this phenomenon, clinicians' references to it were generally oblique or periphrastic. The closest available word was transvestism. The definition of transvestism accepted by the end of the twentieth century, however, did not just fail to capture the wide range of erotically arousing cross-gender behaviors and fantasies in which women's garments per seplay a small role or none at all; it actually directed attention away from them. The absence of an adequate terminology became acute in the writer's research on the taxonomy of gender identity disorders in biological males. This had suggested that heterosexual, asexual, and bisexual transsexuals are more similar to each other-and to transvestites-than any of them is to the homosexual type, and that the common feature in transvestites and the three types of non-homosexual transsexuals is a history of erotic arousal in association with the thought or image of themselves as women. At the same time, the writer was becoming aware of male patients who are sexually aroused only by the idea of having a woman's body and not at all by the idea of wearing women's clothes. To fill this terminological and conceptual gap, the writer introduced the term autogynephilia(love of oneself as a woman).

  1. The Conservation of Early Post-Medieval Period Coins Found in Estonia

    Directory of Open Access Journals (Sweden)

    Aive Viljus

    2013-02-01

    Full Text Available This article deals with archaeological find material with a low silver content and the problems of conserving such material. The aim of the research was to find the most suitable method for the conservation of poorly preserved early post-medieval period coins with varying composition. For this, first, the composition of both the metal and the corrosion products of the archaeological coins were analysed, after which comparative experiments of different cleaning methods were carried out in order to find out the least harmful and most efficient method. A test was also performed to determine the necessity and efficiency of stabilizing the surface of the coins after cleaning.

  2. Episodes from the Early History of Astronomy

    Science.gov (United States)

    Aaboe, Asger

    The author does not attempt to give a general survey of early astronomy; rather, he chooses to present a few "episodes" and treats them in detail. However, first he provides the necessary astronomical background in his descriptive account of what you can see when you look at the sky with the naked eye, unblinkered by received knowledge, but with curiosity and wit. Chapter 1 deals with the arithmetical astronomy of ancient Mesopotamia where astronomy first was made an exact science. Next are treated Greek geometrical models for planetary motion, culminating in Ptolemy's equant models in his Almagest. Ptolemy does not assign them absolute size in this work, but, as is shown here, if we scale the models properly, they will yield good values, not only of the directions to the planets, but of the distances to them, as well. Thus one can immediately find the dimensions of the Copernican System from parameters in the Almagest - we have evidence that Copernicus did just that. Further, Islamic astronomers' modifications of Ptolemy's models by devices using only uniform circular motion are discussed, as are Copernicus's adoption of some of them. finally, it is made precise which bothersome problem was resolved by the heliocentric hypothesis, as it was by the Tychonic arrangement. Next, the Ptolemaic System, the first cosmological scheme to incorporate quantitative models, is described as Ptolemy himself did it in a recenlty recovered passage from his Planetary Hypotheses. Here he does assign absolute size to his models in order to fit them into the snugly nested spherical shells that made up his universe. This much maligned system was, in fact, a harmonious construct that remained the basis for how educated people thought of their world for a millennium and a half. Finally, after a brief review of the geometry of the ellipse, the author gives an elementary derivation of Kepler's equation, and shows how Kepler solved it, and further proves that a planet moves very nearly

  3. The early history of the placebo.

    Science.gov (United States)

    Jütte, Robert

    2013-04-01

    In the late 18th century the term "placebo" became part of medical jargon. In contrast to the prevailing opinion that it was the Scottish physician and pharmacologist William Cullen (1710-1790) who introduced this expression into medical language in 1772, the credit must be given to another English physician, Alexander Sutherland (born before 1730 - died after 1773). The main reason for administering placebos in late 18th-century medical practice was to satisfy the patient's demand and his expectations. Another reason was obstinancy of the patient: the motivation behind such prescriptions may be summarized as prescribing inert drugs for the satisfaction of the patient's mind, and not with the view of producing any direct remedial effect. In most cases these 18th century physicians did not administer "pure" placebos but resorted to any kind of medicine which they thought simple, feeble, or altogether powerless, non-perturbing medicines. Today we make the distinction between pure placebos (substances with no pharmacological effect, e.g. sugar pills) and impure placebos (substances with pharmacological effect but not on the condition being treated). In the 18th century those physicians who prescribed placebo usually thought of drugs which were considered not very effective in the particular case, e.g. a mild ointment. At the same time, only very few brilliant minds came up with the ingenious idea of using inert substances as placebo. An alternative to milk sugar used as placebo in homeopathy was breadpills. Recent research suggests that expectancy is an integral part of the placebo effect. As early as 1775 the English bishop John Douglas (1721-1807) anticipated the findings of modern research on the placebo effect. Copyright © 2012 Elsevier Ltd. All rights reserved.

  4. The Hanford Site: An anthology of early histories

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, M.S.

    1993-10-01

    This report discusses the following topics: Memories of War: Pearl Harbor and the Genesis of the Hanford Site; safety has always been promoted at the Hanford Site; women have an important place in Hanford Site history; the boom and bust cycle: A 50-year historical overview of the economic impacts of Hanford Site Operations on the Tri-Cities, Washington; Hanford`s early reactors were crucial to the sites`s history; T-Plant made chemical engineering history; the UO{sub 3} plant has a long history of service. PUREX Plant: the Hanford Site`s Historic Workhorse. PUREX Plant Waste Management was a complex challenge; and early Hanford Site codes and jargon.

  5. The Early History of UC Santa Cruz's Farm and Garden

    OpenAIRE

    Lee, Paul; Norris, Phyllis; Martin, Orin; Tamura, Dennis; Hagege, Maya; Jarrell, Randall; Regional History Project, UCSC Library

    2002-01-01

    The Early History of UCSC's Farm and Garden documents the emergence of the organic gardening and farming movement in Santa Cruz. It includes interviews with Paul Lee, Phyllis Norris, Orin Martin, and Dennis Tamura, who were involved in the early years of the Garden. Maya Hagege, a former Farm and Garden apprentice and UCSC alumna, conducted the interviews, which were edited by Jarrell. Established in 1967 by master gardener Alan Chadwick, the original site was a neglected 4-acre plot...

  6. Assembling the dodo in early modern natural history.

    Science.gov (United States)

    Lawrence, Natalie

    2015-09-01

    This paper explores the assimilation of the flightless dodo into early modern natural history. The dodo was first described by Dutch sailors landing on Mauritius in 1598, and became extinct in the 1680s or 1690s. Despite this brief period of encounter, the bird was a popular subject in natural-history works and a range of other genres. The dodo will be used here as a counterexample to the historical narratives of taxonomic crisis and abrupt shifts in natural history caused by exotic creatures coming to Europe. Though this bird had a bizarre form, early modern naturalists integrated the dodo and other flightless birds through several levels of conceptual categorization, including the geographical, morphological and symbolic. Naturalists such as Charles L'Ecluse produced a set of typical descriptive tropes that helped make up the European dodo. These long-lived images were used for a variety of symbolic purposes, demonstrated by the depiction of the Dutch East India enterprise in Willem Piso's 1658 publication. The case of the dodo shows that, far from there being a dramatic shift away from emblematics in the seventeenth century, the implicit symbolic roles attributed to exotic beasts by naturalists constructing them from scant information and specimens remained integral to natural history.

  7. Diptera Brachycera found inside the esophagus of a mummified adult male from the early XIX century, Lisbon, Portugal

    Directory of Open Access Journals (Sweden)

    Márcia Souto Couri

    2008-03-01

    Full Text Available Fly puparia and adult fragments of diptera muscid were found inside the esophagus of a mummified body from the early XIX century, buried inside the crypt of the Sacrament Church (Lisbon, Portugal. The identification of the material revealed a monospecific colonization by Ophyra capensis (Wiedemann (Diptera: Muscidae, a species known to invade corpses in the ammoniacal fermentation wave. This species can be found in corpses kept indoors, not available to the early waves of blowflies (Diptera: Calliphoridae. In the present case, the number of pupae and their developmental stage suggest that the female invaded the mummified corpse through the partially opened mouth and the oviposition took place directly inside the esophagus. This is the first case of O. capensis infesting internal organs of an intact corpse. The use of chemical products for the embalming process probably explains why external colonization did not occur.

  8. Time Development in the Early History of Social Networks

    DEFF Research Database (Denmark)

    Bruun, Jesper; Bearden, Ian

    2014-01-01

    Studies of the time development of empirical networks usually investigate late stages where lasting connections have already stabilized. Empirical data on early network history are rare but needed for a better understanding of how social network topology develops in real life. Studying students who...... are beginning their studies at a university with no or few prior connections to each other offers a unique opportunity to investigate the formation and early development of link patterns and community structure in social networks. During a nine week introductory physics course, first year physics students were...... asked to identify those with whom they communicated about problem solving in physics during the preceding week. We use these students' self reports to produce time dependent student interaction networks. We investigate these networks to elucidate possible effects of different student attributes in early...

  9. A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer.

    Science.gov (United States)

    Ma, Jing; Yang, Jichun; Jian, Wenjing; Wang, Xianming; Xiao, Deyong; Xia, Wenjun; Xiong, Likuan; Ma, Duan

    2017-04-01

    Breast cancer is the most frequent female malignancy worldwide. Among them, some cases have hereditary susceptibility in two leading genes, BRCA1 and BRCA2. Heterozygous germ line mutations in them are related with increased risk of breast, ovarian and other cancer, following autosomal dominant inheritance mode. For purpose of early finding, early diagnosis and early treatment, mutation detecting of BRCA1/2 genes was performed in unselected 300 breast or ovarian patients and unaffected women using next-generation sequencing and then confirmed by Sanger sequencing. A non-previously reported heterozygous mutation c.8946_8947delAG (p.D2983FfsX34) of BRCA2 gene was identified in an unaffected Chinese woman with family history of breast cancer (her breast cancer mother, also carrying this mutation). The BRCA2-truncated protein resulted from the frame shift mutation was found to lose two putative nuclear localization signals and a Rad51-binding motif in the extreme C-terminal region by bioinformatic prediction. And then in vitro experiments showed that nearly all the mutant protein was unable to translocate to the nucleus to perform DNA repair activity. This novel mutant BRCA2 protein is dysfunction. We classify the mutation into disease causing and conclude that it is the risk factor for breast cancer in this family. So, conducting the same mutation test and providing genetic counseling for this family is practically meaningful and significant. Meanwhile, the identification of this new mutation enriches the Breast Cancer Information Core database, especially in China.

  10. Pre-mare cratering and early solar system history

    International Nuclear Information System (INIS)

    Wetherill, G.W.

    1974-01-01

    An evaluation of the application of the high extra-lunar flux in pre-mare times to more general problems of early solar system history is attempted by combining the results of dynamic studies with lunar chronological data. Dynamical studies permit separate evaluation of the possible sources for both the normal flux during the first 600 m.y. years of lunar history as well as the peak which apparently occurred 4.0 b.y. ago. Dynamical studies have been carried out in order to determine the extent to which a heliocentric flux could be confined to the Moon (and Earth). A Monte Carlo method has been used to calculate the relative impact rates of planet-crossing bodies with the moon and the terrestrial planets. It is concluded that the time-variation of the flux on these planets is closely related to that on the moon

  11. Early History of Heavy Isotope Research at Berkeley

    Energy Technology Data Exchange (ETDEWEB)

    Glenn T. Seaborg

    1976-06-01

    I have had the idea for some time that it would be interesting and worthwhile to put together an account of the early work on heavy isotopes at Berkeley. Of a special interest is the discovery of plutonium (atomic number 94) and the isotope U{sup 233}, and the demonstration of their fission with slow neutrons. This work served as a prelude to the subsequent Plutonium Project (Metallurgical Project) centered at the University of Chicago, in connection with which I have also had the idea of putting together a history of the work of my chemistry group. I have decided that it would be an interesting challenge to write this account on a day-to-day basis in a style that would be consistent with the entries having been written at the end of each day. The aim would be to make this history as accurate as possible by going back to the original records and using them with meticulous care.

  12. The History Of Muhammadiyahs Thought And Movement Study On Personality And Idea Of The Founding Figure KH. Ahmad Dahlan

    Directory of Open Access Journals (Sweden)

    Fauji Koda

    2017-08-01

    Full Text Available Muhammadiyah is one of the pioneers of religious renewal in Indonesia. As a religious reformist Muhammadiyah has contributed greatly in the development of the majority of Indonesias people are Muslims. This research is a study of the thought and movement of Muhammadiyah in Indonesia aims to conduct a study in order to understand the history and ideas of the Muhammadiyah movement focused on the personality of the founder KH. Ahmad Dahlan and the idea of social renewal Muhammadiyah movement. Study of this scientific work using qualitative paradigm with historical-phenomenological approach which examines the history and phenomenon of Muhammadiyah from aspects of personality and thoughts and ideas of KH. Ahmad Dahlan revealed in external actions words and deeds in developing Muhammadiyah in Indonesia. The results of this study indicate that the birth of Muhammadiyah in Indonesia is strongly influenced by the Islamic reform movement in the world the basic idea of thinking founder of Muhammadiyah is the unity of humanity which has implications for the doctrine to achieve welfare and peace of all mankind the idea of social reform Muahmmadiyah refers to movement Tajdid which includes purification and renewal modernization.

  13. Telomere biology in aging and cancer: early history and perspectives.

    Science.gov (United States)

    Hayashi, Makoto T

    2018-01-20

    The ends of eukaryotic linear chromosomes are protected from undesired enzymatic activities by a nucleoprotein complex called the telomere. Expanding evidence indicates that telomeres have central functions in human aging and tumorigenesis. While it is undoubtedly important to follow current advances in telomere biology, it is also fruitful to be well informed in seminal historical studies for a comprehensive understanding of telomere biology, and for the anticipation of future directions. With this in mind, I here summarize the early history of telomere biology and current advances in the field, mostly focusing on mammalian studies relevant to aging and cancer.

  14. The quantum defect: Early history and recent developments

    International Nuclear Information System (INIS)

    Rau, A.R.; Inokuti, M.

    1997-01-01

    The notion of the quantum defect is important in atomic and molecular spectroscopy and also in unifying spectroscopy with collision theory. In the latter context, the quantum defect may be viewed as an ancestor of the phase shift. However, the origin of the term open-quotes quantum defectclose quotes does not seem to be explained in standard textbooks. It occurred in a 1921 paper by Schroedinger, preceding quantum mechanics, yet giving the correct meaning as an index of the short-range interactions with the core of an atom. We present the early history of the quantum-defect idea, and sketch its recent developments. copyright 1997 American Association of Physics Teachers

  15. An early history of human breast cancer: West meets East.

    Science.gov (United States)

    Yan, Shou-He

    2013-09-01

    Cancer has been increasingly recognized as a global issue. This is especially true in countries like China, where cancer incidence has increased likely because of changes in environment and lifestyle. However, cancer is not a modern disease; early cases have been recorded in ancient medical books in the West and in China. Here, we provide a brief history of cancer, focusing on cancer of the breast, and review the etymology of ai, the Chinese character for cancer. Notable findings from both Western and Chinese traditional medicine are presented to give an overview of the most important, early contributors to our evolving understanding of human breast cancer. We also discuss the earliest historical documents to record patients with breast cancer.

  16. Charles Darwin’s lost Cinereous Harrier found in the collection of the National Museum of Natural History Leiden

    NARCIS (Netherlands)

    Grouw, van H.; Steinheimer, F.D.

    2008-01-01

    During reorganisation of the Leiden bird collection a mounted harrier was found what seemed to be one of the still lost specimens collected by Darwin. After closer research it turned out it was indeed the last missing harrier of the Darwin collection.

  17. The physics and early history of the intergalactic medium

    International Nuclear Information System (INIS)

    Barkana, Rennan; Loeb, Abraham

    2007-01-01

    The intergalactic medium-the cosmic gas that fills the great spaces between the galaxies-is affected by processes ranging from quantum fluctuations in the very early Universe to radiative emission from newly formed stars. This gives the intergalactic medium a dual role as a powerful probe both of fundamental physics and of astrophysics. The heading of fundamental physics includes conditions in the very early Universe and cosmological parameters that determine the age of the Universe and its matter content. The astrophysics refers to chapters of the long cosmic history of stars and galaxies that are being revealed through the effects of stellar feedback on the cosmic gas. This review describes the physics of the intergalactic medium, focusing on recent theoretical and observational developments in understanding early cosmic history. In particular, the earliest generation of stars is thought to have transformed the Universe from darkness to light and to have had an enormous impact on the intergalactic medium. Half a million years after the Big Bang the Universe was filled with atomic hydrogen. As gravity pulled gas clouds together, the first stars ignited and their radiation turned the surrounding atoms back into free electrons and ions. From the observed spectral absorption signatures of the gas between us and distant sources, we know that the process of reionization pervaded most of space a billion years after the Big Bang, so that only a small fraction of the primordial hydrogen atoms remained between galaxies. Knowing exactly when and how the reionization process happened is a primary goal of cosmologists, because this would tell us when the early stars and black holes formed and in what kinds of galaxies. The distribution and clustering of these galaxies is particularly interesting since it is driven by primordial density fluctuations in the dark matter. Cosmic reionization is beginning to be understood with the help of theoretical models and computer

  18. Early Thermal History of Rhea: The Role of Serpentinization and Liquid State Convection

    OpenAIRE

    Czechowski Leszek; Łosiak Anna

    2016-01-01

    Early thermal history of Rhea is investigated. The role of the following parameters of the model is investigated: time of beginning of accretion, tini, duration of accretion, tac, viscosity of ice close to the melting point, η0, activation energy in the formula for viscosity, E, thermal conductivity of silicate component, ksil, ammonia content, XNH3, and energy of serpentinization, cserp. We found that tini and tac are crucial for evolution. All other parameters are also important, but no dra...

  19. Glycosyltransferase family 43 is also found in early eukaryotes and has three subfamilies in Charophycean green algae.

    Directory of Open Access Journals (Sweden)

    Rahil Taujale

    Full Text Available The glycosyltransferase family 43 (GT43 has been suggested to be involved in the synthesis of xylans in plant cell walls and proteoglycans in animals. Very recently GT43 family was also found in Charophycean green algae (CGA, the closest relatives of extant land plants. Here we present evidence that non-plant and non-animal early eukaryotes such as fungi, Haptophyceae, Choanoflagellida, Ichthyosporea and Haptophyceae also have GT43-like genes, which are phylogenetically close to animal GT43 genes. By mining RNA sequencing data (RNA-Seq of selected plants, we showed that CGA have evolved three major groups of GT43 genes, one orthologous to IRX14 (IRREGULAR XYLEM14, one orthologous to IRX9/IRX9L and the third one ancestral to all land plant GT43 genes. We confirmed that land plant GT43 has two major clades A and B, while in angiosperms, clade A further evolved into three subclades and the expression and motif pattern of A3 (containing IRX9 are fairly different from the other two clades likely due to rapid evolution. Our in-depth sequence analysis contributed to our overall understanding of the early evolution of GT43 family and could serve as an example for the study of other plant cell wall-related enzyme families.

  20. The history of CERN during the early 1950s

    International Nuclear Information System (INIS)

    Amaldi, E.

    1989-01-01

    This paper, written by CERN's first secretary general, looks at the history of CERN, the first example of an intergovernmental research laboratory created in Europe, which has now been operating successfully for more than thirty years. Three distinct periods of development are identified. Early initiatives sprang from a growing sense of European union, and a desire to gain the benefits of collaboration in scale, that United States examples such as Brookhaven National Laboratory had offered. The first big project was to build a 10GeV proton-synchrotron, at that time the largest in the world. The middle era corresponds to the establishment of the organization, with personnel assembling, and buildings and plant coming on line. In October 1954, with Felix Bloch as its director general, CERN entered its final permanent form. The synchrocyclotron operated in 1958 and a proton beam circulated in the proton-synchrotron in November 1959. (UK)

  1. On the early history of the Finnish Meteorological Institute

    Science.gov (United States)

    Nevanlinna, H.

    2014-03-01

    This article is a review of the foundation (in 1838) and later developments of the Helsinki (Finland) magnetic and meteorological observatory, today the Finnish Meteorological Institute (FMI). The main focus of the study is in the early history of the FMI up to the beginning of the 20th century. The first director of the observatory was Physics Professor Johan Jakob Nervander (1805-1848). He was a famous person of the Finnish scientific, academic and cultural community in the early decades of the 19th century. Finland was an autonomously part of the Russian Empire from 1809 to 1917, but the observatory remained organizationally under the University of Helsinki, independent of Russian scientific institutions, and funded by the Finnish Government. Throughout the late-19th century the Meteorological Institute was responsible of nationwide meteorological, hydrological and marine observations and research. The observatory was transferred to the Finnish Society of Sciences and Letters under the name the Central Meteorological Institute in 1881. The focus of the work carried out in the Institute was changed gradually towards meteorology. Magnetic measurements were still continued but in a lower level of importance. The culmination of Finnish geophysical achievements in the 19th century was the participation to the International Polar Year programme in 1882-1883 by setting up a full-scale meteorological and magnetic observatory in Sodankylä, Lapland.

  2. The early history of ideas on brief interventions for alcohol.

    Science.gov (United States)

    McCambridge, Jim; Cunningham, John A

    2014-04-01

    This study explores the early development of brief interventions for alcohol using a history of ideas approach with a particular focus on intervention content. The source publications of the key primary studies published from approximately 1962 to 1992 were examined, followed by a brief review of the earliest reviews in this field. These studies were placed in the context of developments in alcohol research and in public health. After early pioneering work on brief interventions, further advances were not made until thinking about alcohol problems and their treatment, most notably on controlled drinking, along with wider changes in public health, created new conditions for progress. There was then a golden era of rapid advance in the late 1980s and early 1990s, when preventing the development of problem drinking became important for public health reasons, in addition to helping already problematic drinkers. Many research challenges identified at that time remain to be met. The content of brief interventions changed over the period of study, although not in ways well informed by research advances, and there were also obvious continuities, with a renewed emphasis on the facilitation of self-change being one important consequence of the development of internet applications. Ideas about brief interventions have changed in important ways. Brief interventions have been studied with different populations of drinkers, with aims embracing both individual and population-level perspectives, and without well-specified contents. The brief intervention field is an appropriate target for further historical investigations, which may help thinking about addressing alcohol and other problems. © 2013 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.

  3. Rare variants in calcium homeostasis modulator 1 (CALHM1 found in early onset Alzheimer's disease patients alter calcium homeostasis.

    Directory of Open Access Journals (Sweden)

    Fanny Rubio-Moscardo

    Full Text Available Calcium signaling in the brain is fundamental to the learning and memory process and there is evidence to suggest that its dysfunction is involved in the pathological pathways underlying Alzheimer's disease (AD. Recently, the calcium hypothesis of AD has received support with the identification of the non-selective Ca(2+-permeable channel CALHM1. A genetic polymorphism (p. P86L in CALHM1 reduces plasma membrane Ca(2+ permeability and is associated with an earlier age-at-onset of AD. To investigate the role of CALHM1 variants in early-onset AD (EOAD, we sequenced all CALHM1 coding regions in three independent series comprising 284 EOAD patients and 326 controls. Two missense mutations in patients (p.G330D and p.R154H and one (p.A213T in a control individual were identified. Calcium imaging analyses revealed that while the mutation found in a control (p.A213T behaved as wild-type CALHM1 (CALHM1-WT, a complete abolishment of the Ca(2+ influx was associated with the mutations found in EOAD patients (p.G330D and p.R154H. Notably, the previously reported p. P86L mutation was associated with an intermediate Ca(2+ influx between the CALHM1-WT and the p.G330D and p.R154H mutations. Since neither expression of wild-type nor mutant CALHM1 affected amyloid ß-peptide (Aß production or Aß-mediated cellular toxicity, we conclude that rare genetic variants in CALHM1 lead to Ca(2+ dysregulation and may contribute to the risk of EOAD through a mechanism independent from the classical Aß cascade.

  4. From the early history of X-ray documentation

    International Nuclear Information System (INIS)

    Beck, A.

    1988-01-01

    By chance, eight X-ray plates dating from 1899 were found in 1986. Each of these glass plates shows the patient's name and the date of the examinations, which were performed in Vienna by Prof. Franz Exner, who was a friend of W.C. Roentgen. The glass plates are 25x13 cm and 10x18 cm in area and 3 mm thick. One side is coated with silver bromide. Probably these are some of the earliest X-ray records in the history of radiology. Their quality is comparable with the quality that can be achieved today, even though the materials and the imaging method used were somewhat unsophisticated. (orig.) [de

  5. Parents as Change Agents in Their Schools and Communities: The Founding of Families for Early Autism Treatment (FEAT)

    Science.gov (United States)

    Mickahail, Bethany K.

    2010-01-01

    A qualitative research highlights how parent driven "communities of support" create lasting change in schools and communities, through the unique blend of the two methodologies, oral history and educational criticism and connoisseurship. In recent years, schools and communities are unusually impacted by an escalating wave in the diagnosis and…

  6. Genome sequencing highlights the dynamic early history of dogs.

    Directory of Open Access Journals (Sweden)

    Adam H Freedman

    2014-01-01

    Full Text Available To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of dog domestication, two basal dog lineages (Basenji and Dingo and a golden jackal as an outgroup. Analysis of these sequences supports a demographic model in which dogs and wolves diverged through a dynamic process involving population bottlenecks in both lineages and post-divergence gene flow. In dogs, the domestication bottleneck involved at least a 16-fold reduction in population size, a much more severe bottleneck than estimated previously. A sharp bottleneck in wolves occurred soon after their divergence from dogs, implying that the pool of diversity from which dogs arose was substantially larger than represented by modern wolf populations. We narrow the plausible range for the date of initial dog domestication to an interval spanning 11-16 thousand years ago, predating the rise of agriculture. In light of this finding, we expand upon previous work regarding the increase in copy number of the amylase gene (AMY2B in dogs, which is believed to have aided digestion of starch in agricultural refuse. We find standing variation for amylase copy number variation in wolves and little or no copy number increase in the Dingo and Husky lineages. In conjunction with the estimated timing of dog origins, these results provide additional support to archaeological finds, suggesting the earliest dogs arose alongside hunter-gathers rather than agriculturists. Regarding the geographic origin of dogs, we find that, surprisingly, none of the extant wolf lineages from putative domestication centers is more closely related to dogs, and, instead, the sampled wolves form a sister monophyletic clade. This result, in combination with dog-wolf admixture during the process of domestication, suggests that a re-evaluation of past hypotheses regarding dog

  7. Bichordites from the early Eocene of Cuba: significance in the evolutionary history of the spatangoids

    Science.gov (United States)

    Villegas-Martín, Jorge; Netto, Renata Guimarães

    2017-12-01

    The trace fossil Bichordites monastiriensis is found in early Eocene turbiditic sandstones of the upper-slope deposits from the Capdevila Formation in Los Palacios Basin, Pinar del Río region, western Cuba. The potential tracemakers of B. monastiriensis include fossil spatangoids from the family Eupatagidae. The record of Bichordites in the deposits from Cuba allows to suppose that Eupatagidae echinoids were the oldest potential tracemakers of Bichordites isp. and reinforce the hypothesis that the ichnological record are relevant in envisaging the evolutionary history of the spatangoids.

  8. [An early history of Japanese amyotrophic lateral sclerosis (ALS)-related diseases and the current development].

    Science.gov (United States)

    Abe, Koji

    2018-03-28

    The present review focuses an early history of Japanese amyotrophic lateral sclerosis (ALS)-related diseases and the current development. In relation to foreign previous reports, five topics are introduced and discussed on ALS with dementia, ALS/Parkinsonism dementia complex (ALS/PDC), familial ALS (FALS), spinal bulbar muscular atrophy (SBMA), and multisystem involvement especially in cerebellar system of ALS including ALS/SCA (spinocerebellar ataxia) crossroad mutation Asidan. This review found the great contribution of Japanese reports on the above five topics, and confirmed the great development of ALS-related diseases over the past 120 years.

  9. The fascinating early history of optics! Archaeological optics 2009: our knowledge of the early history of lenses, mirrors, and artificial eyes!

    Science.gov (United States)

    Enoch, Jay M.

    2009-08-01

    The early history of optics and vision science (older term: physiological optics) is indeed fascinating. The earliest known true lenses have been found in "eyes" of Egyptian statues which contain superb, complex, and well-polished eye-lens units. The oldest ones known are dated circa 2575 BCE = BC, Dynasty IV, Old Kingdom. These eye-lens units induce a fascinating and powerful visual illusion, but they are just too good to have been the first lenses, or even the first lenses of this design! So saying, no earlier dateable lenses have been found in Egypt or elsewhere. Recently, at the Boston Museum of Fine Arts, the writer noted a previously undetected lens in this series (a first in the Western Hemisphere). Oddly, dateable simpler magnifying lenses and burning glasses seem to have appeared later in time (?)! Manufactured mirrors are quite a bit older, dating from circa 6000 BCE in atal Hyk, located in south-central modern-day Turkey. Using these ancient mirrors, the image quality obtained is remarkable! Recently discovered ancient artificial eyes, located, in situ, in exhumed corpses, have been dated circa 3000 BCE (one discovered in Iran) 5000 BCE (one found in Spain). On the 3000 BCE artificial eye, there are drawn light rays (the writer believes these to be the oldest known depiction of light rays!) spreading out from (or passing into) the iris/ pupil border! Added interesting aspects associated with the early development of light-rays are considered. Thus, early optics can be readily traced back to the Neolithic era (the new stone age), and in some cases before that time period. We have deep roots indeed!

  10. Local adaptation in brown trout early life-history traits: implications for climate change adaptability

    DEFF Research Database (Denmark)

    Jensen, L.F.; Hansen, Michael Møller; Pertoldi, C.

    2008-01-01

    to adapt. Temperature-related adaptability in traits related to phenology and early life history are expected to be particularly important in salmonid fishes. We focused on the latter and investigated whether four populations of brown trout (Salmo trutta) are locally adapted in early life-history traits...

  11. Family history of premature death and risk of early onset cardiovascular disease

    DEFF Research Database (Denmark)

    Ranthe, Mattis Flyvholm; Carstensen, Lisbeth; Oyen, Nina

    2012-01-01

    The purpose of this study was to examine the effect of a family history of premature death, cardiovascular death in particular, on the risk of early cardiovascular disease.......The purpose of this study was to examine the effect of a family history of premature death, cardiovascular death in particular, on the risk of early cardiovascular disease....

  12. Conservative secondary structure motifs already present in early-stage folding (in silico) as found in serpines family.

    Science.gov (United States)

    Brylinski, Michal; Konieczny, Leszek; Kononowicz, Andrzej; Roterman, Irena

    2008-03-21

    The well-known procedure implemented in ClustalW oriented on the sequence comparison was applied to structure comparison. The consensus sequence as well as consensus structure has been defined for proteins belonging to serpine family. The structure of early stage intermediate was the object for similarity search. The high values of W(sequence) appeared to be accordant with high values of W(structure) making possible structure comparison using common criteria for sequence and structure comparison. Since the early stage structural form has been created according to limited conformational sub-space which does not include the beta-structure (this structure is mediated by C7eq structural form), is particularly important to see, that the C7eq structural form may be treated as the seed for beta-structure present in the final native structure of protein. The applicability of ClustalW procedure to structure comparison makes these two comparisons unified.

  13. Family History - An Early Warning for Your Child

    Centers for Disease Control (CDC) Podcasts

    2007-11-14

    Collecting family history information could save your child's life. Listen to learn more about how knowing your family history information could benefit your entire family.  Created: 11/14/2007 by National Center on Birth Defects and Developmental Disabilities.   Date Released: 11/28/2007.

  14. Early Thermal History of Rhea: The Role of Serpentinization and Liquid State Convection

    Science.gov (United States)

    Czechowski, Leszek; Łosiak, Anna

    2016-12-01

    Early thermal history of Rhea is investigated. The role of the following parameters of the model is investigated: time of beginning of accretion, tini, duration of accretion, tac, viscosity of ice close to the melting point, η0, activation energy in the formula for viscosity, E, thermal conductivity of silicate component, ksil, ammonia content, XNH3, and energy of serpentinization, cserp. We found that tini and tac are crucial for evolution. All other parameters are also important, but no dramatic differences are found for realistic values. The process of differentiation is also investigated. It is found that liquid state convection could delay the differentiation for hundreds of My. The results are confronted with observational data from Cassini spacecraft. It is possible that differentiation is fully completed but the density of formed core is close to the mean density. If this interpretation is correct, then Rhea could have accreted any time before 3-4 My after formation of CAI.

  15. Early-Type Galaxy Star Formation Histories in Different Environments

    Science.gov (United States)

    Fitzpatrick, Patrick; Graves, G.

    2014-01-01

    We use very high-S/N stacked spectra of ˜29,000 nearby quiescent early-type galaxies (ETGs) from the Sloan Digital Sky Survey (SDSS) to investigate variations in their star formation histories (SFHs) with environment at fixed position along and perpendicular to the Fundamental Plane (FP). We separate galaxies in the three-dimensional FP space defined by galaxy effective radius Re, central stellar velocity dispersion σ, and surface brightness residual from the FP, ΔIe. We use the SDSS group catalogue of Yang et al. to further separate galaxies into three categories by their “identities” within their respective dark matter halos: central “Brightest Group Galaxies” (BGGs); Satellites; and Isolateds (those which are “most massive” in a dark matter halo with no Satellites). Within each category, we construct high-S/N mean stacked spectra to determine mean singleburst ages, [Fe/H], and [Mg/Fe] based on the stellar population synthesis models of R. Schiavon. This allows us to study variations in the stellar population properties (SPPs) with local group environment at fixed structure (i.e., fixed position in FP-space). We find that the SFHs of quiescent ETGs are almost entirely determined by their structural parameters σ and ΔIe. Any variation with local group environment at fixed structure is only slight: Satellites have the oldest stellar populations, 0.02 dex older than BGGs and 0.04 dex older than Isolateds; BGGs have the highest Fe-enrichments, 0.01 dex higher than Isolateds and 0.02 dex higher than Satellites; there are no differences in Mg-enhancement between BGGs, Isolateds, and Satellites. Our observation that, to zeroth-order, the SFHs of quiescent ETGs are fully captured by their structures places important qualitative constraints on the degree to which late-time evolutionary processes (those which occur after a galaxy’s initial formation and main star-forming lifetime) can alter their SFHs/structures.

  16. Francis Bacon's natural history and the Senecan natural histories of early modern Europe.

    Science.gov (United States)

    Jalobeanu, Dana

    2012-01-01

    At various stages in his career, Francis Bacon claimed to have reformed and changed traditional natural history in such a way that his new "natural and experimental history" was unlike any of its ancient or humanist predecessors. Surprisingly, such claims have gone largely unquestioned in Baconian scholarship. Contextual readings of Bacon's natural history have compared it, so far, only with Plinian or humanist natural history. This paper investigates a different form of natural history, very popular among Bacon's contemporaries, but yet unexplored by contemporary students of Bacon's works. I have provisionally called this form of natural history'Senecan' natural history, partly because it took shape in the Neo-Stoic revival of the sixteenth-century, partly because it originates in a particular cosmographical reading of Seneca's Naturales quaestiones. I discuss in this paper two examples of Senecan natural history: the encyclopedic and cosmographical projects of Pierre de la Primaudaye (1546-1619) and Samuel Purchas (1577-1626). I highlight a number of similarities between these two projects and Francis Bacon's natural history, and argue that Senecan natural history forms an important aspect in the historical and philosophical background that needs to be taken into consideration if we want to understand the extent to which Bacon's project to reform natural history can be said to be new.

  17. Early Life Histories of Fishes: New Developmental, Ecological and ...

    African Journals Online (AJOL)

    ontogeny and life history models revisited' which is an unabridged .... Hamburg, Germany, in August 1984. The papers are ..... Cambridge University Press, Cambridge, New York and ... lessons to be learnt from the well-illustrated keys and for.

  18. Family history influences the early onset of hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Chung-Hwa Park; Seung-Hee Jeong; Hyeon-Woo Yim; Jin Dong Kim; Si Hyun Bae; Jong Young Choi; Seung Kew Yoon

    2012-01-01

    AIM:To evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma (HCC) development in Korean HCC patients.METHODS:We studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008,whose family history of primary liver cancer was clearly described in the medical records.RESULTS:Of the 2242 patients,165 (7.4%) had a positive family history of HCC and 2077 (92.6%) did not.The male to female ratio was 3.6:1,and the major causes of HCC were chronic hepatitis B virus (HBV) infection in 75.1%,chronic hepatitis C virus infection in 13.2% and alcohol in 3.1%.The median ages at diagnosis in the positive-and negative-history groups were 52 years (range:29-79 years) and 57 years (range:18-89 years),respectively (P < 0.0001).Furthermore,among 1713 HCC patients with HBV infection,the number of patients under 45 years of age out of 136 patients with positive family history was 26 (19.1%),whereas those out of 1577 patients with negative family history was 197 (12.5%),suggesting that a positive family history may be associated with earlier development of HCC in the Korean population (P =0.0028).CONCLUSION:More intensive surveillance maybe recommended to those with a positive family history of HCC for earlier diagnosis and proper management especially when HBV infection is present.

  19. Has psychology "found its true path"? Methods, objectivity, and cries of "crisis" in early twentieth-century French psychology.

    Science.gov (United States)

    Carson, John

    2012-06-01

    This article explores how French psychologists understood the state of their field during the first quarter of the twentieth century, and whether they thought it was in crisis. The article begins with the Russian-born psychologist Nicolas Kostyleff and his announcement in 1911 that experimental psychology was facing a crisis. After briefly situating Kostyleff, the article examines his analysis of the troubles facing experimental psychology and his proposed solution, as well as the rather muted response his diagnosis received from the French psychological community. The optimism about the field evident in many of the accounts surveying French psychology during the early twentieth century notwithstanding, a few others did join Kostyleff in declaring that all was not well with experimental psychology. Together their pronouncements suggest that under the surface, important unresolved issues faced the French psychological community. Two are singled out: What was the proper methodology for psychology as a positive science? And what kinds of practices could claim to be objective, and in what sense? The article concludes by examining what these anxieties reveal about the type of science that French psychologists hoped to pursue. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. FDG-PET/CT detection of very early breast cancer in women with breast microcalcification lesions found in mammography screening

    International Nuclear Information System (INIS)

    Peng, Nang-Jing; Chou, Chen-Pin; Pan, Huay-Ben; Chang, Tsung-Hsien; Hu, Chin; Chiu, Yu-Li; Fu, Ting-Ying; Chang, Hong-Tai

    2015-01-01

    To assess the efficacy of positron emission tomography/computed tomography with the glucose analogue 2-[ 18 F]fluoro-2-deoxy-D-glucose (FDG-PET/CT) in Taiwanese women with early breast cancer detected by mammography screening. Dual-time-point imaging of whole-body supine and breast prone scans using FDG-PET/CT were performed sequentially in the pre-operative stage. A total of 11,849 patients underwent screening mammography, of whom 1,209 (10.2%) displayed positive results. After further investigation, 54 patients underwent FDG-PET/CT. Post-operative pathology examinations revealed malignancies in 26 lesions, including invasive breast cancer in 11 cases and non-invasive breast cancer in 15 cases, as well as benign disease in 30 lesions. The FDG-PET/CT findings from the whole-body scans were positive for 9 of 11 invasive breast cancers (81.8%) and 3 of 15 non-invasive cancers (20%), and they were negative for all benign lesions. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of FDG-PET/CT with whole-body supine imaging were 46.2%, 100%, 100% and 68.2%, respectively. Breast prone imaging revealed another patient with ductal carcinoma in situ, increasing the sensitivity to 50%. Importantly, positive PET findings were significantly correlated with tumour histology (P = 0.006), tumour size (P = 0.039) and Ki-67 expression (P = 0.011). FDG-PET/CT with whole-body scanning demonstrated high sensitivity to invasive breast cancer, limited sensitivity to non-invasive breast cancer, and high specificity for breast cancer. FDG-PET/CT might be useful for differentiating tumour invasiveness. However, the good PPV but poor NPV do not allow the physician to discard the biopsy.

  1. LATE-BREAKING ABSTRACT: Early relapse of non-small cell lung cancer (NSCLC) found after CNS-symptoms

    DEFF Research Database (Denmark)

    Hansen, Niels-Chr. G.; Laursen, Christian B.; Jeppesen, Stefan S.

    2016-01-01

    whether the introduction in 2010 of follow-up by CT of thorax and upper abdomen every three months has reduced the incidence of relapse suspected from CNS-symptoms.Results: All 827 NSCLC patients from Funen completing curative treatment from 2005 to 2013 were included. The total number of relapses found...... or III were found.Conclusion: CT-based follow-up has not reduced the incidence of relapse suspected from CNS-symptoms in stage II-IV, and therefore we suggest routine MR of the brain before curative treatment for this group of patients.Number, fractions(%), and [95%CI]Jan. 2005 - June 2010July 2010 - Dec...... after symptoms within 24 months decreased in the 3½ years after the introduction of CT-based follow-up, p < 0,001 (table), but the total fraction presenting with CNS-symptoms did not change, p = 0.296. Relapses after stage I cancer decreased (p = 0.025), while no differences or changes for stages II...

  2. Pathogenic fungi found in wheat seeds and medium early maturity, produced in three parts of Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Anderson Durante Danelli

    2012-03-01

    Full Text Available Seed samples of wheat harvest in 2010 from Santo Augusto, Passo Fundo and Vacaria, RS; were plated on gerbox acrylic sterilized culture medium PSA (potato, sucrose and agar plus antibiotics. Were used 400 seeds of each cultivar total of 45 cultivars. Were distributed equally spaced 25 seeds in each seedling with four replications, totaling 100 seeds per replicate. The seeds were incubated at 25 ± 2°C in an incubator with a photoperiod of 12 hours for 12 days. The experimental design was blocks and the experimental unit consists of four gerbox containing 25 seeds each. Was considered to be infected the seed of conidiophore presence and/or conidia of the fungus. The data were transformed to (x+11/2 and subjected to analysis of variance and means compared by Tukey test at 5% probability. Fungi F. graminearum and Alternaria spp. were detected in high incidence in most lots, performing at respectively 96.0% and 98.0% of samples, thereafter Bipolaris spp. So too, Drechslera siccans was found in 41.5% of samples showing that their incidence is increasing

  3. Writing Chinese art history in early twentieth-century China

    NARCIS (Netherlands)

    Guo, Hui

    2010-01-01

    My dissertation argues that Chinese scholars of the 1920s and ’30s (re)interpreted the traditions of Chinese art in order to build a modern field of Chinese art history. These scholars faced with challenges such as China’s internal needs to develop, her indirect and direct encounters with

  4. Learning Early Twentieth-Century History through First-Person Interviews

    Science.gov (United States)

    Lark, Lisa A.

    2007-01-01

    For many of the students in the author's American history class, early twentieth-century American history seems far removed from their daily lives. Being first and second-generation American citizens, many of the students do not have the luxury of hearing grandparents and great-grandparents telling stories about FDR and Henry Ford. More…

  5. Early history of tree seedling nurseries in the South

    Science.gov (United States)

    James P. Barnett

    2013-01-01

    The forests in the South were devastated by aggressive harvesting that began following the Civil War. By the early in the 20th century, many millions of acres of land needed reforestation. Foresighted individuals began a committed effort to restore this land to a productive condition. This effort required dedication, innovation, cooperation, and leadership. The...

  6. Early Indian History and the Legacy of DD Kosambi1

    Indian Academy of Sciences (India)

    that the beginnings of Hinduism lay in these ideas and practices. Religion was and .... ing from the extension of plough agriculture and the establishing of agrarian ..... tion of early historical urban centres in the Ganges plain and the north-west.

  7. Oral history of Florence Downs; the early years.

    Science.gov (United States)

    Fairman, J; Mahon, M M

    2001-01-01

    Florence Downs is a well-recognized nursing leader, educator, editor, and scholar who helped shape nursing as an intellectual discipline, and wrote extensively about the importance of links between research and practice. Through the use of oral history data garnered over 15 hours of interviews, we constructed a narrative that describes some of Downs' formative experiences. Oral history is used to place the "stories" of an individual into a social and cultural context, in this case, the development of the profession of nursing. From the interviews, several strands emerged that defined Downs' extended career, including the importance of developing a community of scholars both in and outside of nursing, the dangers of parochialism, and the necessity of a perspective on life that melded a keen sense of humor. Factors that affected Downs' style and choice, especially her mother, and her educational experiences, were revealed. From the interviews we gained a sense of how Downs constructed her conceptual universe of nursing, as well as the language and political effectiveness to overcome barriers confronting the intellectual growth of nursing mounted by other nursing leaders as well as traditional academic disciplines.

  8. Informing Educational Decisions in the Early Years: Can Evidence for Improving Pedagogy for Children with Autistic Spectrum Disorder Be Found from Neuroscience?

    Science.gov (United States)

    Peters, Brenda; Forlin, Chris

    2011-01-01

    It is possible that many benefits may be found for all concerned in education and child development in understanding how knowledge of the brain and its development can inform early years practice. This article, written by Brenda Peters and Chris Forlin, both from the Hong Kong Institute of Education, reviews literature based on neuroscience to…

  9. Social Confidence in Early Adulthood among Young People with and without a History of Language Impairment

    Science.gov (United States)

    Durkin, Kevin; Toseeb, Umar; Botting, Nicola; Pickles, Andrew; Conti-Ramsden, Gina

    2017-01-01

    Purpose: The purposes of this study were to test the predictions that lower self-esteem and higher shyness in individuals with a history of language impairment (LI) would continue from adolescence into early adulthood and that those with LI would have lower social self-efficacy in early adulthood. Method: Participants were young people with a…

  10. Diffuse thyroid uptake incidentally found on 1'8{sup F}-Flurodeoxygluse position emission tomography in subjects without cancer history

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ji Young; Choi, Joon Young; Choi, Yoon Ho; Hyun, Seung Hyup; Moon, Seung Hwan; Jang, Su Jin; Cheo, Yeam Seung; Lee, Kyung Han; Kim, Byung Tae [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2013-06-15

    We investigated the clinical significance of incidental diffuse thyroid uptake (DTU) on 1{sup 8F}-FDG PET in subjects without a history of cancer. This study included 2062 studies from adults who underwent 1{sup 8F}-FDG PET as a cancer screening program. Subjects were divided into the following two groups: with (group I) or without (group II) DTU. The presence of DTU and the thyroid visual grading score were compared with thyroid function tests, serum anti-microsomal antibody (AMA) levels, and the presence of diffuse parenchymal change (DPC) on ultrasonography (USG). DTU was found in 6.6% of the scans (137/2062). Serum thyroid stimulating hormone (TSH) and AMA levels were significantly higher in group I than in group II. Increased AMA level (55.1%) and DPC (48.7%) were more frequently found in group I (p < 0.001). The proportion of subjects with any abnormal results in serum free thyroxine, triiodothyronine, TSH, or AMA levels or DPC on USG was significantly higher in group I than in group II (71.5% vs. 10.6%, p < 0.001), and was significantly and gradually increased according to the visual grading score group (0 vs. 1-2 vs. 3-4 = 10.6% vs. 58.5% vs. 90.9%, p < 0.001). TSH and is AMA levels were significantly increased according to the visual grading score. The presence or degree of incidental DTU on 1{sup 8F}-FDG PET is closely correlated with increased serum AMA and TSH levels, and the presence of DPC on USG. Therefore, the most plausible pathological cause of DTU may be cell damage by an autoimmune mechanism.

  11. Early History of BELL'S Theorem Theory and Experiment

    Science.gov (United States)

    Clauser, John F.

    Before 1980 it was unfashionable for a physicist to admit that he either did not understand and/or doubted the Truth and/or Orthodoxy of Quantum Mechanics (QM). Contemporary wisdom deemed it impossible that it may lead to incorrect predictions. Thus, it was foolish to suggest that it warranted further testing. Said wisdom proclaimed that nothing would ever be gained by any such pursuit. Bohr had won his debates with Einstein. Von Neumann had proven all other interpretations wrong. That was the end to it! Only an iconoclast dared think otherwise. Here I provide a brief history of some of my encounters with a few fellow iconoclasts, past denizens of a QM doubter's subculture.

  12. Highlights from the early (and pre-) history of reliability engineering

    International Nuclear Information System (INIS)

    Saleh, J.H.; Marais, K.

    2006-01-01

    Reliability is a popular concept that has been celebrated for years as a commendable attribute of a person or an artifact. From its modest beginning in 1816-the word reliability was first coined by Samuel T. Coleridge-reliability grew into an omnipresent attribute with qualitative and quantitative connotations that pervades every aspect of our present day technologically intensive world. In this short communication, we highlight key events and the history of ideas that led to the birth of Reliability Engineering, and its development in the subsequent decades. We first argue that statistics and mass production were the enablers in the rise of this new discipline, and the catalyst that accelerated the coming of this new discipline was the (unreliability of the) vacuum tube. We highlight the foundational role of AGREE report in 1957 in the birth of reliability engineering, and discuss the consolidation of numerous efforts in the 1950s into a coherent new technical discipline. We show that an evolution took place in the discipline in the following two decades along two directions: first, there was an increased specialization in the discipline (increased sophistication of statistical techniques, and the rise of a new branch focused on the actual physics of failure of components, Reliability Physics); second, there occurred a shift in the emphasis of the discipline from a component-centric to an emphasis on system-level attributes (system reliability, availability, safety). Finally, in selecting the particular events and highlights in the history of ideas that led to the birth and subsequent development of reliability engineering, we acknowledge a subjective component in this work and make no claims to exhaustiveness

  13. YOU CAN TALK ABOUT HISTORY CRITICAL PEDAGOGY TO THINK EARLY CHILDHOOD EDUCATION?

    Directory of Open Access Journals (Sweden)

    Alessandra Arce

    2013-12-01

    Full Text Available This article is the result of the research work been carried on by the research group History of Education and Early Childhood Education at Federal University of São Carlos. The aim of this paper is to present possibilities and paths for the application of the principles of Pedagogia Histórico-Crítica for Early Childhood Education. Therefore we expect that this article generate discussions in order to improve methodologically and pedagogically our Early Childhood Education.

  14. Early history of the Cosmotron and AGS at Brookhaven

    International Nuclear Information System (INIS)

    Courant, E.D.

    1989-01-01

    Early work is described on the design and construction of the two Brookhaven particle accelerators of the 1950s, the Cosmotron and the AGS (alternating-gradient synchrotron). The Cosmotron, finished by the Spring of 1952, was the smaller machine reaching 3GeV and was the first to pass the billion electron volt mark. Suggested alterations to magnet orientations meant that the alternating gradients produced would stabilize the design. This ''strong-focusing'' idea was central to the second AGS machine, which also overcame the problems of resonances and transition energy, with the inclusion of an electron analog accelerator. (UK)

  15. Early history of neutron scattering at Oak Ridge

    International Nuclear Information System (INIS)

    Wilkinson, M.K.

    1985-07-01

    Most of the early development of neutron scattering techniques utilizing reactor neutrons occurred at the Oak Ridge National Laboratory during the years immediately following World War II. C.G. Shull, E.O. Wollan, and their associates systematically established neutron diffraction as a quantitative research tool and then applied this technique to important problems in nuclear physics, chemical crystallography, and magnetism. This article briefly summarizes the very important research at ORNL during this period, which laid the foundation for the establishment of neutron scattering programs throughout the world. 47 refs., 10 figs

  16. History of pancreaticoduodenectomy: early misconceptions, initial milestones and the pioneers.

    Science.gov (United States)

    Are, Chandrakanth; Dhir, Mashaal; Ravipati, Lavanya

    2011-06-01

    Pancreaticoduodenectomy is one of the most challenging surgical procedures which requires the highest level of surgical expertise. This procedure has constantly evolved over the years through the meticulous efforts of a number of surgeons before reaching its current state. This review navigates through some of the early limitations and misconceptions and highlights the initial milestones which laid the foundation of this procedure. The current review also provides a few excerpts from the lives and illuminates on some of the seminal contributions of the three great surgeons: William Stewart Halsted, Walther Carl Eduard Kausch and Allen Oldfather Whipple. These surgeons pioneered the nascent stages of this procedure and paved the way for the modern day pancreaticoduodenectomy. © 2011 International Hepato-Pancreato-Biliary Association.

  17. The SSC dipole: Its conceptual origin and early design history

    International Nuclear Information System (INIS)

    Dahl, P.F.

    1992-05-01

    The magnet system for the Superconducting Super Collider will likely remain the most ambitions-and challenging-application of superconducting technology for the foreseeable future. The centerpiece of the system is the behemoth collider dipole magnet. Its design, still evolving in its detailed features, dates from the mid-1980's when it emerged as the winter in an early technical showdown that occupied the fledgling SSC project. In the present report we chronicle the origins and chief milestones in the development of certain SSC dipole design concepts. Unfortunately, the chronicle must remain incomplete, with the design not yet frozen as we go to press and still subject to important modifications as the SSC Laboratory settles in near its future home in Ellis County, Texas, hard on the heels of a wide-ranging design review in the closing days of the SSC Central Design Group in (CDG) Berkeley. Be that as it may, in what follows we concentrate on the early years in an attempt to recapitulate the birth of the dipole, taking as our point of departure the SSC Reference Designs Study (RDS) of 1984. In Section 3 we touch on the background for the various RDS options, including ISABELLE/CBA and the Tevatron. In Section 4 the narrative focuses on the two final protagonists, a high-field cosine theta (cos θ) magnet and a low-field superferric magnet. Section 5 recounts the circumstances surrounding the selection of a particular magnet ''style'' for further development, and the ups and downs of the first model magnets. We conclude with a smattering of progress highlights in refining the design during the final push under the reign of the CDG. Beyond that, the ongoing chronicle must be left for others to amplify and complete

  18. The SSC dipole: Its conceptual origin and early design history

    International Nuclear Information System (INIS)

    Dahl, P.F.

    1990-06-01

    The magnet system for the Superconducting Super Collider will likely remain the most ambitious -- and challenging -- application of superconducting technology for the foreseeable future. The centerpiece of the system is the behemoth collider dipole magnet. Its design, still evolving in its detailed features, dates from the mid-1980's when it emerged as the winner in an early technical showdown that occupied the fledgling SSC project. However, some of its gross features can be traced back to three path-breaking superconducting accelerator initiatives under way a decade earlier -- on the East Coast, on the West Coast, and in the Midwest. Other features have a still earlier legacy. In the present report we chronicle the origins and chief milestones in the development of certain SSC dipole design concepts. Unfortunately, the chronicle must remain incomplete, with the design not yet frozen as we go to press and still subject to important modifications as the SSC Laboratory settles in near its future home in Ellis County, Texas, hard on the heels of a wide-ranging design review in the closing days of the SSC Central Design Group in (CDG) Berkeley. Be that as it may, in what follows we concentrate on the early years in an attempt to recapitulate the birth of the dipole, taking as our point of departure the SSC Reference Designs Study (RDS) of 1984. In Section 3 we touch on the background for the various RDS options, including ISABELLE/CBA and the Tevatron. In Section 4 the narrative focuses on the two final protagonists, a high-field cosine theta (cos θ) magnet and a low-field superferric magnet. Section 5 recounts the circumstances surrounding the selection of a particular magnet ''style'' for further development, and the ups and downs of the first model magnets. We conclude with a smattering of progress highlights in refining the design during the final push under the reign of the CDG

  19. The invention and early history of the CCD

    International Nuclear Information System (INIS)

    Smith, George E.

    2009-01-01

    As the first practical solid-state imaging device, the invention of the Charge Coupled Device has profoundly affected image sensing technology. They are used in a wide range of applications as both area and linear imaging devices starting with the replacement of imaging tubes used in commercial TV cameras and camcorders. The rapid increase of their use in digital cameras has initiated the demise of film photography and created vast new markets with great economic benefit for many. Other uses include a wide variety of scientific, surveillance and scanning applications. The inception of the device at Bell Labs by Willard S. Boyle and George E. Smith in 1969 was strongly influenced by several unique factors existing both within Bell Labs and the current world state of technology. These factors and their relevance will be discussed along with the train of thought leading to the invention. Early experimental devices and their initial applications were vigorously pursued and will be described. Current applications will be mentioned.

  20. Ptychography: early history and 3D scattering effects

    Science.gov (United States)

    Rodenburg, J. M.

    2012-01-01

    The coherent diffractive imaging method of ptychography is first reviewed from a general historical perspective. Much more recent progress in extending the method to the 3D scattering geometry and the super-resolution configuration is also described. Ptychography was originally conceived by Walter Hoppe as a solution to the X-ray or electron crystallography phase problem. Although the existence of this type of phase information was clearly evident in the early 1970s, the technique was not implemented at atomic-scale wavelengths until the 1990s, and then only in a way that was computationally inefficient, especially in view of the limited size of computers at that time. Fast and efficient ptychographic algorithms were developed much later, in the mid-2000s. The extremes of crystallography ptychography, which only requires two diffraction patterns, and the Wigner Distribution Deconvolution (WDDC) method, which needs a diffraction pattern for every pixel of the final reconstruction, are described. Very recent work relating to the application of serial iterative to 3D inversion are also described.

  1. Early stages in the history of gas chromatography.

    Science.gov (United States)

    Kolomnikov, Ivan G; Efremov, Alexander M; Tikhomirova, Tatyana I; Sorokina, Nadezhda M; Zolotov, Yury A

    2018-02-16

    The creation of gas chromatography is traditionally associated with the names of Nobel Prize winner Archer Martin and his colleagues Richard Synge and Anthony James. However, sometimes references to their predecessors can be found. An investigation conducted by the authors of this article not only confirmed the reliability of these references; but in fact led to the conclusion that by 1952, which is commonly believed to be the year when gas chromatography was born, many research papers had already been devoted to this method, mainly, in its gas-solid version. These papers are considered in this article. Copyright © 2018. Published by Elsevier B.V.

  2. Early East Asian art history in Vienna and its trajectories: Josef Strzygowski, Karl With, Alfred Salmony

    Directory of Open Access Journals (Sweden)

    Julia Orell

    2015-12-01

    Full Text Available In 1912 Josef Strzygowski founded the ‘Section for East Asian Art History’ at the University of Vienna, which attracted many students who would continue their careers in museums and at universities and thus established East Asian art history as an academic field. This paper examines these early art historical engagements with East Asian art: First, I discuss the role of East Asian art in Strzygowski’s agenda of broadening art history’s geographical scope beyond Europe and in his argument about the dominance of ‘Nordic’ artistic traditions in Europe and in Asia. Secondly, I introduce the work of two early students at the ‘Section for East Asian Art History’ in Vienna, Karl With and Alfred Salmony. Their respective approaches to East Asian art exemplify a range of methodological concerns of their time, from stylistic narratives, the concept of ars una, comparative frameworks, to ideas about cultural or national ‘purity’ in the arts, and an interest in cross-cultural adaption and transformation of motifs and symbolism.

  3. Family history of premature death and risk of early onset cardiovascular disease.

    Science.gov (United States)

    Ranthe, Mattis Flyvholm; Carstensen, Lisbeth; Oyen, Nina; Tfelt-Hansen, Jacob; Christiansen, Michael; McKenna, William J; Wohlfahrt, Jan; Melbye, Mads; Boyd, Heather A

    2012-08-28

    The purpose of this study was to examine the effect of a family history of premature death, cardiovascular death in particular, on the risk of early cardiovascular disease. Studies suggest that fatal cardiovascular events and less severe cardiovascular diseases may co-occur in families. Consequently, a family history of premature death may indicate a familial cardiac frailty that predisposes to early cardiovascular disease. We ascertained family history of premature death (age Denmark from 1950 to 2008 and followed this cohort for early cardiovascular disease (age history of premature cardiovascular death in first-degree relatives were 1.72 (95% confidence interval [CI]: 1.68 to 1.77), 2.21 (95% CI: 2.11 to 2.31), and 1.94 (95% CI: 1.70 to 2.20), respectively. With ≥2 cardiovascular deaths in a family, corresponding IRRs were 3.30 (95% CI: 2.77 to 3.94), 5.00 (95% CI: 3.87 to 6.45), and 6.18 (95% CI: 3.32 to 11.50). The IRR for any early cardiovascular disease given a family history of premature noncardiovascular death was significantly lower, 1.12 (95% CI: 1.10 to 1.14) (p(cardiac vs. noncardiac) history of premature cardiovascular death was consistently and significantly associated with a risk of early cardiovascular disease, suggesting an inherited cardiac vulnerability. These results should be kept in mind when assessing cardiovascular disease risk in persons with a family history of premature cardiovascular death. Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  4. Early history of experimental inertial confinement fusion and diagnostics in China

    International Nuclear Information System (INIS)

    Wang Chuanke; Jiang Shao'en; Ding Yongkun

    2014-01-01

    The early history of China's research on experimental laser inertial confinement fusion (ICF) and diagnostics technology is reviewed. The long and difficult path started from scratch, from learning the basics, looking up the literature and copying experiments, to independent research and development of comprehensive experimental facilities. This article fills a gap in the history of China's ICF experimental and diagnostics research. (authors)

  5. Proposals for innovation in teaching of history in early childhood education

    Directory of Open Access Journals (Sweden)

    Pedro Miralles Martínez

    2012-04-01

    Full Text Available The authors advocate the teaching of history at an early age, working about learning of time, (already observed in the current curriculum, and historical contents and procedures to historical research. And from experimental experience with positive results, they establish a series of innovative proposals for an appropriate inclusion of history in school with 3-6 years old pupils, with particular attention to working by projects in the classroom.

  6. Early history and reactivation of the rand thrust, southern California

    Science.gov (United States)

    Postlethwaite, Clay E.; Jacobson, Carl E.

    The Rand thrust of the Rand Mountains in the northwestern Mojave Desert separates an upper plate of quartz monzonite and quartzofeldspathic to amphibolitic gneiss from a lower plate of metagraywacke and mafic schist (Rand Schist). The Rand thrust is considered part of the regionally extensive Vincent/Chocolate Mountain thrust system, which is commonly believed to represent a Late Cretaceous subduction zone. The initial direction of dip and sense of movement along the Vincent/Chocolate Mountain thrust are controversial. Microfabrics of mylonites and quartzites from the Rand Mountains were analyzed in an attempt to determine transport direction for this region, but the results are ambiguous. In addition, the southwestern portion of the Rand thrust was found to have been reactivated as a low-angle normal fault after subduction. Reactivation might have occurred shortly after subduction, in which case it could account for the preservation of high-pressure mineral assemblages in the Rand Schist, or it could be related to mid-Tertiary extension in the western United States. In either event, the reactivation might be responsible for the complicated nature of the microfabrics. The Rand Schist exhibits an inverted metamorphic zonation. Isograds in the schist are not significantly truncated by the reactivated segment of the Rand thrust. This indicates that other segments of the Vincent/Chocolate Mountain thrust should be re-evaluated for the possibility of late movement, even if they show an apparently undisturbed inverted metamorphic zonation.

  7. The Acapulco Parent Planetesimal: An Early Collisional History in the Solar System

    Science.gov (United States)

    Marti, K.; Kim, Y.

    2007-05-01

    The Acapulco, Mexico, meteorite was recovered in 1976 from a crater of approx. 30 cm diameter. An old crystallization age of 4.60 (error 0.03) Ga (Prinzhofer et al., 1992) establishes that its parent object is one of the oldest known planetesimals in the solar system, although not in a pristine form. Other dating systems indicated somewhat younger ages and isotopic variabilities in several elements documented a complex early history. The younger ages date the closure times in secondary minerals. The initial parent object was in a partially molten state when isotopically distinct foreign matter invaded the chondritic parent and some of the isotopic signatures survived. Nitrogen in the primitive achondrite Acapulco was found to have distinct isotopic signatures for the metal and silicate phases and also in different morphologies of graphites (El Goresy, 1995, 2005). The delayed collisional event probably disrupted the parent object, as Acapulco cooled very rapidly. Nitrogen in the injected metal and graphite did not isotopically exchange with the host silicates. We observed nitrogen isotopic signatures of several separated mineral phases which cover a range of delta 15N values from -150 permil to +13 permil. The lightest nitrogen signatures observed in metal separates are comparable to those in some morphologies of Acapulco graphites. The heavy N signatures observed in several silicate minerals are consistent with each other, while nitrogen in chromite is distinctly light (delta 15N of -80 permil), intermediate between those of metal and silicates. The incipient rapid cooling history is well documented down to approx. 120° C, as recorded by U/Th-4He ages in phosphates (Min et al., 2003). The history of the Acapulco parent object was uneventful after its early evolution in an environment where no perturbation by collisions occurred, until the meteorite's recent (6.0 Ma ago) injection into an earth-crossing orbit. References: El Goresy, A., Zinner, E., and Marti, K

  8. The benefit of early treatment without rescreening in women with a history of gestational diabetes.

    LENUS (Irish Health Repository)

    Maher, Nicola

    2013-02-01

    In this center, women with a history of gestational diabetes (GDM) are treated without rescreening from early pregnancy in any subsequent pregnancies, commencing with a low glycemic diet and insulin if and when indicated. The objective of this study was to see if this practice reduced the incidence of macrosomia compared with the index pregnancy.

  9. Teaching the Past in the Early Modern Era: Two Different Ways to Make Use of History

    Science.gov (United States)

    Bruter, Annie

    2012-01-01

    Were teachers, of the early modern era not longing for the present? Most colleges of that time did not offer a history course. Still, they did teach a lot about the past since the teaching consisted in the reading of the works of ancient writers. This is because ancient science and literature were considered much more advanced than the science and…

  10. Building an Evidence-Based Mental Health Program for Children with History of Early Adversity

    Science.gov (United States)

    Kroupina, Maria; Vermeulen, Marlous; Moberg, Stephanie

    2015-01-01

    Adoption is a major intervention in a child's life, however internationally adopted (IA) children remain at risk for long-term neurodevelopmental and mental health issues due to the fact that most of them have a history of early adversity prior to their adoption. In the last 20 years, extensive research with this population has increased the…

  11. Tensions in Constructions of Quality in Australian Early Childhood Education and Care Policy History

    Science.gov (United States)

    Logan, Helen

    2017-01-01

    In pronouncements of early childhood education and care (ECEC) policy the importance of quality appears as a seemingly irrefutable concept. Yet, attention to ECEC policy history reveals tensions between discourses that construct quality in ways that endure whereas other ways are ostensibly forgotten. Drawing on a Foucauldian-influenced…

  12. The Early History of the European Conferences on Science and Religion and of ESSSAT

    NARCIS (Netherlands)

    Drees, W.B.

    The early history of the European Conferences on Science and Religion and ESSSAT, the European Society for the Study of Science And Theology, is documented and discussed. In Europe, there were, and still are, genuine differences in attitude towards methodology, ideas about the reach of knowledge,

  13. Impaired 8-Hydroxyguanine Repair Activity of MUTYH Variant p.Arg109Trp Found in a Japanese Patient with Early-Onset Colorectal Cancer

    Directory of Open Access Journals (Sweden)

    Kazuya Shinmura

    2014-01-01

    Full Text Available Purpose. The biallelic inactivation of the 8-hydroxyguanine repair gene MUTYH leads to MUTYH-associated polyposis (MAP, which is characterized by colorectal multiple polyps and carcinoma(s. However, only limited information regarding MAP in the Japanese population is presently available. Since early-onset colorectal cancer (CRC is a characteristic of MAP and might be caused by the inactivation of another 8-hydroxyguanine repair gene, OGG1, we investigated whether germline MUTYH and OGG1 mutations are involved in early-onset CRC in Japanese patients. Methods. Thirty-four Japanese patients with early-onset CRC were examined for germline MUTYH and OGG1 mutations using sequencing. Results. Biallelic pathogenic mutations were not found in any of the patients; however, a heterozygous p.Arg19*  MUTYH variant and a heterozygous p.Arg109Trp MUTYH variant were detected in one patient each. The p.Arg19* and p.Arg109Trp corresponded to p.Arg5* and p.Arg81Trp, respectively, in the type 2 nuclear-form protein. The defective DNA repair activity of p.Arg5* is apparent, while that of p.Arg81Trp has been demonstrated using DNA cleavage and supF forward mutation assays. Conclusion. These results suggest that biallelic MUTYH or OGG1 pathogenic mutations are rare in Japanese patients with early-onset CRC; however, the p.Arg19* and p.Arg109Trp MUTYH variants are associated with functional impairments.

  14. Geoid and gravity anomaly data of conjugate regions of Bay of Bengal and Enderby Basin: New constraints on breakup and early spreading history between India and Antarctica

    Digital Repository Service at National Institute of Oceanography (India)

    Krishna, K.S.; Michael, L.; Bhattacharyya, R.; Majumdar, T.J.

    the anomalies. Since the magnetic anomalies in the western Enderby Basin have lower amplitude, Gaina et al. (2007) could not identify the anomalies with confidence and found difficulty to correlate the spreading history with that of the central and eastern... Geoid and gravity anomaly data of conjugate regions of Bay of Bengal and Enderby Basin – new constraints on breakup and early spreading history between India and Antarctica K.S. Krishna*, Laju Michael National Institute of Oceanography, Council...

  15. Early life history and habitat ecology of estuarine fishes: responses to natural and human induced change

    Directory of Open Access Journals (Sweden)

    Kenneth Able

    2015-12-01

    Full Text Available Our understanding of the early life history of fishes and their habitats has proceeded from basic natural history to ecology, but we often need to return to natural history to address deficiencies in conceptual and quantitative models of ecosystems. This understanding is further limited by the complex life history of fishes and the lack of appreciation of shifting baselines in estuaries. These inadequacies are especially evident when we try to address the effects of human influences, e.g. fishing, urbanization, and climate change. Often our baselines are inadequate or inaccurate. Our work has detected these along the coasts of the U.S. in extensive time series of larval fish ingress into estuaries, studies of the effects of urbanization, and responses to catastrophes such as the BP oil spill. Long-term monitoring, especially, continues to provide critical insights

  16. The seeds and the worms: Ludwik Fleck and the early history of germ theories

    DEFF Research Database (Denmark)

    Brorson, Stig

    2006-01-01

    -scientific "proto-ideas." In 1935, Fleck proposed that the history of germ theories could be approached through his thesis on proto-ideas. His proposal, however, remained little more than a vague suggestion and was never developed in further detail. This paper introduces the concept of proto-ideas and discusses...... the central epistemological and historiographical implications of Fleck's thesis. The Fleckian approach offers an attractive alternative to positivist reconstructions of the early history of germ theories and provides a useful framework for a deeper understanding of the sociocultural background......The Polish microbiologist and philosopher of science, Ludwik Fleck (1896-1961), was a pioneer in constructivist history and philosophy of science. Based on studies in the history of syphilis, Fleck hypothesized that many established scientific facts are linked, in their development, to pre...

  17. Paternal effects on early life history traits in Northwest Atlantic cod, Gadus morhua

    DEFF Research Database (Denmark)

    Kroll, M.-M.; Peck, M.A.; Butts, Ian A.E.

    2013-01-01

    It is important to understand parental effects on early life history of fish as manifested, for example, in individual fitness of offspring. Immediately after fertilization, parental contributions (both genetic and non-genetic) to embryos will affect larval ontogeny, physiology, morphology...... and survival. In marine fish, rates of natural mortality are highest during early life and are negatively correlated with rates of growth and body size. In these early life stages (eggs, larvae, young juveniles) subtle differences in mortality can cause large differences in recruitment and year-class success...... and can serve as important sources of variation during early life stages in fishes. Overall, these findings have implications for furthering the understanding of recruitment variability and can be used to optimize reproductive output for the aquaculture industry. In addition, the data suggests...

  18. A Third Note: Helmholtz, Palestrina, and the Early History of Musicology.

    Science.gov (United States)

    Kursell, Julia

    2015-06-01

    This contribution focuses on Hermann von Helmholtz's work on Renaissance composer Giovanni Pierluigi da Palestrina. Helmholtz used his scientific concept of distortion to analyze this music and, reversely, to find corroboration for the concept in his musical analyses. In this, his work interlocked with nineteenth-century aesthetic and scholarly ideals. His eagerness to use the latest products of historical scholarship in early music reveals a specific view of music history. Historical documents of music provide the opportunity for the discovery of new experimental research topics and thereby also reveal insights into hearing under different conditions. The essay argues that this work occupies a peculiar position in the history of musicology; it falls under the header of "systematic musicology," which eventually emerged as a discipline of musicology at the end of the nineteenth century. That this discipline has a history at all is easily overlooked, as many of its contributors were scientists with an interest in music. A history of musicology therefore must consider at least the following two caveats: parts of it take place outside the institutionalized field of musicology, and any history of musicology must, in the last instance, be embedded in a history of music.

  19. Approaches to the History of Patients: From the Ancient World to Early Modern Europe.

    Science.gov (United States)

    Stolberg, Michael

    2016-01-01

    This chapter looks from an early modernist's perspective at some of the major questions and methodological issues that writing the history of patients in the ancient world shares with similar work on Patientengeschichte in medieval and early modern Europe. It addresses, in particular, the problem of finding adequate sources that give access to the patients' experience of illness and medicine and highlights the potential as well as the limitations of using physicians' case histories for that purpose. It discusses the doctor-patient relationship as it emerges from these sources, and the impact of the patient's point of view on learned medical theory and practice. In conclusion, it pleads for a cautious and nuanced approach to the controversial issue of retrospective diagnosis, recommending that historians consistently ask in which contexts and in what way the application of modern diagnostic labels to pre-modern accounts of illness can truly contribute to a better historical understanding rather than distort it.

  20. Using GRIDVIEW to Better Understand the Early Bombardment History of the Moon, Mars and Earth

    Science.gov (United States)

    Frey, Herbert

    2012-01-01

    For more than a decade we have used GRIDVIEW to help analyze topographic and related data for Mars and more recently for the Moon. Our focus has been to employ the stretching, contouring, profiling, circle-fitting and other capabilities of GRIDVIEW to search for Quasi-Circular Depressions (CTAs) in MOLA, LOLA and other topographic data, and for Circular Thin Areas (CTAs) in Mars and Moon model crustal thickness data. Both QCDs and CTAs likely represent buried or obscured impact craters not readily visible in image data. We found clear evidence for a much larger population of buried impact craters in the northern lowlands of Mars (Frey et al. 2002), suggesting that part of the Red Planet is not significantly younger than the southern highlands. Edgar and Frey (2008) found that the N(300) crater retention ages of both areas were essentially identical, a conclusion confirmed by Wyatt (unpublished data) using more recent crustal thickness data for Mars. MOLA topographic data and MOLA-derived crustal thickness data were used to both identify a large number of previously unrecognized very large impact basins (D> 1000 km) on Mars and to determine relative crater retention ages for them (Frey, 2008). The distribution of N(300) CRAs suggested most formed in a relatively short interval of time. This dating also suggested the main magnetic field of Mars disappeared during this period (Lillis et al., 2008), because only the youngest basins systematically lack a remagnetized signature. Similar QCD and CTA analysis of first Clementine (Frey, 2011) and more recently LOLA topographic and LOLA-derived crustal thickness data for the Moon (Frey et al., 2011) revealed a significantly larger population of impact basins > 300 km in diameter than previously known. N(50) CRAs suggest a two-peak distribution of ages (Frey, 2012). An improved counting process confirms the two peaks, perhaps indicating both a pre-Nectaris Early Heavy Bombardment (EHB) as well as a Late Heavy Bombardment (LHB

  1. Waiting for the Unicorn: Perception of Time and History in Early Chinese Writings

    OpenAIRE

    Gibas, Piotr Pawel

    2009-01-01

    In this dissertation I examine temporality as conceived in early Chinese historiography, through a systematic examination of four key works: the Mozi, the Zuozhuan, the Rishu;, and the Chu Silk Manuscript, all of them written during 4th through 1st century BCE. Each presents from a different perspective ideas about the mechanism of time and history. While only the Zuozhuan is commonly categorized as historical narrative, all four of these texts depend on records of the past to convey their wo...

  2. Reconstruction of the early invasion history of the quagga mussel (Dreissena rostriformis bugensis) in Western Europe

    OpenAIRE

    Heiler, Katharina; Vaate, Abraham bij de; Ekschmitt, Klemens; Oheimb, Parm von; Albrecht, Christian; Wilke, Thomas

    2013-01-01

    The recent introduction of the quagga mussel into Western European freshwaters marked the beginning of one of the most successful biological invasions during the past years in this region. However, the spatial and temporal origin of the first invasive population(s) in Western Europe as well as subsequent spreading routes still remain under discussion. In this study, we therefore aim at reconstructing the early invasion history of the quagga mussel in Western Europe based on an age-corrected t...

  3. Energetic endpoints provide early indicators of life history effects in a freshwater gastropod exposed to the fungicide, pyraclostrobin

    International Nuclear Information System (INIS)

    Fidder, Bridgette N.; Reátegui-Zirena, Evelyn G.; Olson, Adric D.; Salice, Christopher J.

    2016-01-01

    Organismal energetics provide important insights into the effects of environmental toxicants. We aimed to determine the effects of pyraclostrobin on Lymnaea stagnalis by examining energy allocation patterns and life history traits. Juvenile snails exposed to pyraclostrobin decreased feeding rate and increased apparent avoidance behaviors at environmentally relevant concentrations. In adults, we found that sublethal concentrations of pyraclostrobin did not affect reproductive output, however, there were significant effects on developmental endpoints with longer time to hatch and decreased hatching success in pyraclostrobin-exposed egg masses. Further, there were apparent differences in developmental effects depending on whether mothers were also exposed to pyraclostrobin suggesting this chemical can exert intergenerational effects. Pyraclostrobin also affected protein and carbohydrate content of eggs in mothers that were exposed to pyraclostrobin. Significant effects on macronutrient content of eggs occurred at lower concentrations than effects on gross endpoints such as hatching success and time to hatch suggesting potential value for these endpoints as early indicators of ecologically relevant stress. These results provide important insight into the effects of a common fungicide on important endpoints for organismal energetics and life history. - Highlights: • We exposed a freshwater snail to relevant concentrations of pyraclostrobin. • We monitored energetic and life history endpoints. • Pyraclostrobin affected feeding, hatching success and egg macronutrient content. • Energetic-based endpoints may provide valuable insight to toxic effects. - The fungicide pyraclostrobin at environmentally relevant concentrations effects a range of life history and energetic endpoints in the freshwater snail, Lymnaea stagnalis.

  4. Effects of maternal history of depression and early life maltreatment on children's health-related quality of life.

    Science.gov (United States)

    Dittrich, Katja; Fuchs, Anna; Bermpohl, Felix; Meyer, Justus; Führer, Daniel; Reichl, Corinna; Reck, Corinna; Kluczniok, Dorothea; Kaess, Michael; Hindi Attar, Catherine; Möhler, Eva; Bierbaum, Anna-Lena; Zietlow, Anna-Lena; Jaite, Charlotte; Winter, Sibylle Maria; Herpertz, Sabine C; Brunner, Romuald; Bödeker, Katja; Resch, Franz

    2018-01-01

    There is a well-established link between maternal depression and child mental health. Similar effects have been found for maternal history of early life maltreatment (ELM). However, studies investigating the relationship of children's quality of life and maternal depression are scarce and none have been conducted for the association with maternal ELM. The aim of the present study was to investigate the effects of maternal history of ELM and depression on children's health-related quality of life and to identify mediating factors accounting for these effects. Our study involved 194 mothers with and without history of depression and/or ELM and their children between five and 12 years. Children's health-related quality of life was assessed by maternal proxy- and child self-ratings using the KIDSCREEN. We considered maternal sensitivity and maternal parenting stress as potential mediators. We found an effect of maternal history of depression but not of maternal history of ELM on health-related quality of life. Maternal stress and sensitivity mediated the effects of maternal depression on child global health-related quality of life, as well as on the dimensions Autonomy & Parent Relation, School Environment (maternal and child rating), and Physical Wellbeing (child rating). Due to the cross-sectional design of the study, causal interpretations must be made with caution. Some scales yielded low internal consistency. Maternal impairments in areas of parenting which possibly developed during acute depression persist even after remission of acute affective symptoms. Interventions should target parenting stress and sensitivity in parents with prior depression. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. The Role of Residential Early Parenting Services in Increasing Parenting Confidence in Mothers with A History of Infertility

    Directory of Open Access Journals (Sweden)

    Marjan Lynette

    2016-07-01

    Full Text Available Background Mothers with a history of infertility may experience parenting difficulties and challenges. This study was conducted to investigate the role of residential early parenting services in increasing parenting confidence in mothers with a history of infertility. Materials and Methods This was a retrospective chart review study using the quantitative data from the clients attending the Karitane Residential Units and Parenting Services (known as Karitane RUs during 2013. Parenting confidence (using Karitane Parenting Confidence Scale-KPCS, depression, demographics, reproductive and medical history, as well as child’s information were assessed from a sample of 27 mothers who had a history of infertility and who attended the Karitane RUs for support and assistance. The data were analyzed using SPSS version 19. Results More than half of the women (59.3% reported a relatively low level of parenting confidence on the day of admission. The rate of low parenting confidence, however, dropped to 22.2% after receiving 4-5 days support and training in the Karitane RUs. The mean score of the KPCS increased from 36.9 ± 5.6 before the intervention to 41.1 ± 3.4 after the intervention, indicating an improvement in the parenting confidence of the mothers after attending the Karitane RUs (P<0.0001. No statistically significant association was found between maternal low parenting confidence with parental demographics (including age, country of birth, and employment status, a history of help-seeking, symptoms of depression, as well as child’s information [including gender, age, siblings, diagnosis of gastroesophageal reflux disease (GORD and use of medication]. Conclusion Having a child after a period of infertility can be a stressful experience for some mothers. This can result in low parenting confidence and affect parent-child attachment. Our findings emphasized on the role of the residential early parenting services in promoting the level of

  6. Early parental loss and depression history: associations with recent life stress in major depressive disorder.

    Science.gov (United States)

    Slavich, George M; Monroe, Scott M; Gotlib, Ian H

    2011-09-01

    Although exposure to early adversity and prior experiences with depression have both been associated with lower levels of precipitating life stress in depression, it is unclear whether these stress sensitization effects are similar for all types of stress or whether they are specific to stressors that may be particularly depressogenic, such as those involving interpersonal loss. To investigate this issue, we administered structured, interview-based measures of early adversity, depression history, and recent life stress to one hundred adults who were diagnosed with major depressive disorder. As predicted, individuals who experienced early parental loss or prolonged separation (i.e., lasting one year or longer) and persons with more lifetime episodes of depression became depressed following lower levels of life stress occurring in the etiologically-central time period of three months prior to onset of depression. Importantly, however, additional analyses revealed that these effects were unique to stressors involving interpersonal loss. These data highlight potential stressor-specific effects in stress sensitization and demonstrate for the first time that individuals exposed to early parental loss or separation, and persons with greater histories of MDD, may be selectively sensitized to stressors involving interpersonal loss. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. Tough Adults, Frail Babies: An Analysis of Stress Sensitivity across Early Life-History Stages of Widely Introduced Marine Invertebrates

    Science.gov (United States)

    Pineda, M. Carmen; McQuaid, Christopher D.; Turon, Xavier; López-Legentil, Susanna; Ordóñez, Víctor; Rius, Marc

    2012-01-01

    All ontogenetic stages of a life cycle are exposed to environmental conditions so that population persistence depends on the performance of both adults and offspring. Most studies analysing the influence of abiotic conditions on species performance have focussed on adults, while studies covering early life-history stages remain rare. We investigated the responses of early stages of two widely introduced ascidians, Styela plicata and Microcosmus squamiger, to different abiotic conditions. Stressors mimicked conditions in the habitats where both species can be found in their distributional ranges and responses were related to the selection potential of their populations by analysing their genetic diversity. Four developmental stages (egg fertilisation, larval development, settlement, metamorphosis) were studied after exposure to high temperature (30°C), low salinities (26 and 22‰) and high copper concentrations (25, 50 and 100 µg/L). Although most stressors effectively led to failure of complete development (fertilisation through metamorphosis), fertilisation and larval development were the most sensitive stages. All the studied stressors affected the development of both species, though responses differed with stage and stressor. S. plicata was overall more resistant to copper, and some stages of M. squamiger to low salinities. No relationship was found between parental genetic composition and responses to stressors. We conclude that successful development can be prevented at several life-history stages, and therefore, it is essential to consider multiple stages when assessing species' abilities to tolerate stress. Moreover, we found that early development of these species cannot be completed under conditions prevailing where adults live. These populations must therefore recruit from elsewhere or reproduce during temporal windows of more benign conditions. Alternatively, novel strategies or behaviours that increase overall reproductive success might be

  8. Tough adults, frail babies: an analysis of stress sensitivity across early life-history stages of widely introduced marine invertebrates.

    Directory of Open Access Journals (Sweden)

    M Carmen Pineda

    Full Text Available All ontogenetic stages of a life cycle are exposed to environmental conditions so that population persistence depends on the performance of both adults and offspring. Most studies analysing the influence of abiotic conditions on species performance have focussed on adults, while studies covering early life-history stages remain rare. We investigated the responses of early stages of two widely introduced ascidians, Styela plicata and Microcosmus squamiger, to different abiotic conditions. Stressors mimicked conditions in the habitats where both species can be found in their distributional ranges and responses were related to the selection potential of their populations by analysing their genetic diversity. Four developmental stages (egg fertilisation, larval development, settlement, metamorphosis were studied after exposure to high temperature (30°C, low salinities (26 and 22‰ and high copper concentrations (25, 50 and 100 µg/L. Although most stressors effectively led to failure of complete development (fertilisation through metamorphosis, fertilisation and larval development were the most sensitive stages. All the studied stressors affected the development of both species, though responses differed with stage and stressor. S. plicata was overall more resistant to copper, and some stages of M. squamiger to low salinities. No relationship was found between parental genetic composition and responses to stressors. We conclude that successful development can be prevented at several life-history stages, and therefore, it is essential to consider multiple stages when assessing species' abilities to tolerate stress. Moreover, we found that early development of these species cannot be completed under conditions prevailing where adults live. These populations must therefore recruit from elsewhere or reproduce during temporal windows of more benign conditions. Alternatively, novel strategies or behaviours that increase overall reproductive success

  9. Increased Pre- and Early-Adolescent Stress in Youth with a Family History of Substance Use Disorder and Early Substance Use Initiation.

    Science.gov (United States)

    Charles, Nora E; Mathias, Charles W; Acheson, Ashley; Bray, Bethany C; Ryan, Stacy R; Lake, Sarah L; Liang, Yuanyuan; Dougherty, Donald M

    2015-10-01

    Individuals with a family history of substance use disorders (Family History Positive) are more likely to have early-onset substance use (i.e., prior to age 15), which may contribute to their higher rates of substance use disorders. One factor that may differentiate Family History Positive youth who engage in early-onset substance use from other Family History Positive youth is exposure to stressors. The aim of this study was to quantify how exposure to stressors from age 11-15 varies as a function of family history of substance use disorders and early-onset substance use. Self-reported stressors were prospectively compared in a sample of predominately (78.9%) Hispanic youth that included 68 Family History Positive youth (50% female) who initiated substance use by age 15 and demographically matched non-users with (n = 136; 52.9% female) and without (n = 75; 54.7% female) family histories of substance use disorders. Stressors were assessed at 6-month intervals for up to 4 years. Both the severity of stressors and the degree to which stressors were caused by an individual's own behavior were evaluated. All three groups differed from one another in overall exposure to stressors and rates of increase in stressors over time, with Family History Positive youth who engaged in early-onset substance use reporting the greatest exposure to stressors. Group differences were more pronounced for stressors caused by the participants' behavior. Family History Positive users had higher cumulative severity of stressors of this type, both overall and across time. These results indicate greater exposure to stressors among Family History Positive youth with early-onset substance use, and suggest that higher rates of behavior-dependent stressors may be particularly related to early-onset use.

  10. [Evaluation of quality of life in school children with a history of early severe malnutrition].

    Science.gov (United States)

    De Grandis, E S; Armelini, P A; Cuestas, E

    2014-12-01

    Severe malnutrition in young children may lead to long-term complications, in particular learning and psychosocial disorders linked to health related quality of life (HRQOL). The aim of this study was to evaluate HRQOL in children whit a history of severe malnutrition before 2 years of life, expecting to find lower scores in these patients. A comparative study was performed on schoolchildren between 5 and 12 years with a history of early severe malnutrition, excluding those with chronic diseases. The Controls were healthy siblings of patients. The sample size was estimated as 26 subjects per group (Total=52). Sociodemographic variables were recorded and the HRQOL was assessed with PedsQL4.0. Chi square and Student t test were applied. Significance level: Psocial dimension: 88.80±3.05 vs 95.71±1.52 (P<.0001), and school dimension: 74.58±3.80 vs 85.00±3.51 (P<.0001). Patients with a history of early severe malnutrition, showed significantly lower HRQOL scores compared with controls. Copyright © 2013 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  11. A review of noble gas geochemistry in relation to early Earth history

    Science.gov (United States)

    Kurz, M. D.

    1985-01-01

    One of the most fundamental noble gas constraints on early Earth history is derived from isotopic differences in (129)Xe/(130)Xe between various terrestrial materials. The short half life (17 m.y.) of extinct (129I, parent of (129)Xe, means that these differences must have been produced within the first 100 m.y. after terrestrial accretion. The identification of large anomalies in (129)Xe/(130)Xe in mid ocean ridge basalts (MORB), with respect to atmospheric xenon, suggests that the atmosphere and upper mantle have remained separate since that time. This alone is a very strong argument for early catastrophic degassing, which would be consistent with an early fractionation resulting in core formation. However, noble gas isotopic systematics of oceanic basalts show that the mantle cannot necessarily be regarded as a homogeneous system, since there are significant variations in (3)He/(4)He, (40)Ar/(36)Ar, and (129)Xe/(130)Xe. Therefore, the early degassing cannot be considered to have acted on the whole mantle. The specific mechanisms of degassing, in particular the thickness and growth of the early crust, is an important variable in understanding present day noble gas inventories. Another constraint can be obtained from rocks that are thought to be derived from near the lithosphere asthenosphere boundary: ultramafic xenoliths.

  12. Understanding factors associated with early therapeutic alliance in PTSD treatment: adherence, childhood sexual abuse history, and social support.

    Science.gov (United States)

    Keller, Stephanie M; Zoellner, Lori A; Feeny, Norah C

    2010-12-01

    Therapeutic alliance has been associated with better treatment engagement, better adherence, and less dropout across various treatments and disorders. In treatment of posttraumatic stress disorder (PTSD), it may be particularly important to establish a strong early alliance to facilitate treatment adherence. However, factors such as childhood sexual abuse (CSA) history and poor social support may impede the development of early alliance in those receiving PTSD treatment. We sought to examine treatment adherence, CSA history, and social support as factors associated with early alliance in individuals with chronic PTSD who were receiving either prolonged exposure therapy (PE) or sertraline. At pretreatment, participants (76.6% female; 64.9% Caucasian; mean age = 37.1 years, SD = 11.3) completed measures of trauma history, general support (Inventory of Socially Supportive Behaviors), and trauma-related social support (Social Reactions Questionnaire). Over the course of 10 weeks of PE or sertraline, they completed early therapeutic alliance (Working Alliance Inventory) and treatment adherence measures. Early alliance was associated with PE adherence (r = .32, p history was not predictive of a lower early alliance. Given the associations with adherence, clinicians may find it useful to routinely assess alliance early in treatment. Positive trauma support, not CSA history, may be particularly important in the development of a strong early therapeutic alliance. (c) 2010 APA, all rights reserved.

  13. Thermal expansion and thermal stress in the moon and terrestrial planets - Clues to early thermal history

    Science.gov (United States)

    Solomon, S. C.; Chaiken, J.

    1976-01-01

    The paper discusses how features of the surface geology of the moon and also Mars and Mercury impose constraints on the volumetric expansion or contraction of a planet and consequently provide a test of thermal history models. The moon has changed very little in volume over the last 3.8 b.y. Thermal models satisfying this constraint involve early heating and perhaps melting of the outer 200 km of the moon and an initially cold interior. Mercury has contracted by about 2 km in radius since emplacement of its present surface, so core formation must predate that surface. A hot initial temperature distribution is implied.

  14. The ''Uranium Society''. Looking at the early history of radiation protection

    International Nuclear Information System (INIS)

    Nagel, G.

    2000-01-01

    The contribution initially looks at the early days of research activities conducted inter alia under an ''atomic research programme'' of the Third Reich, highlighting essential steps and experiments in the history, the foundation of the 'Uranverein' (uranium society) and the avtivities of the group of scientists around Heisenberg. The author presents information that answers the question of whether and how the scientists in those days have been thinking of adequate protection against harmful and toxic effects of the uranium material they were handling. The first instructions for on-the-job safety and protective measures recommended at the time are reported, and are also illustrated by some pictures. (orig./CB) [de

  15. A Didactic Approach between Music and History: Military Images in Early 19th-Century Concertos

    Directory of Open Access Journals (Sweden)

    Luca Aversano

    2015-12-01

    Full Text Available This article looks at the representation of military images in the violin and orchestra concerts of the early 19th century in a didactic perspective. It introduces a reflection on methodology that focuses on the way in which school teaching can connect the analysis of past musical forms with the history of European culture. At the same time, the essay provides an example for a possible didactic approach, conceived essentially for upper secondary schools, but also potentially useful for teachers at other school levels.

  16. Rethinking the early history of post-Vygotskian psychology: the case of the Kharkov school.

    Science.gov (United States)

    Yasnitsky, Anton; Ferrari, Michel

    2008-05-01

    Between the death of Vygotsky in 1934 and the discovery of Vygotsky's work in the West in 1962, Vygotskian psychology was developed through research done by the first generation of Vygotsky's students and their followers, primarily associated with the Kharkov School. Surprisingly, these studies carried out in the 1930s, of great importance for the development of virtually all subsequent Vygotskian psychology, still remain largely unknown; this represents a significant gap in understanding the history of Vygotskian psychology as an empirical study of consciousness. This paper provides a systematic overview of the research agenda of the Kharkov group between 1931 and 1941 and provides new insights into the early development of Vygotskian psychology.

  17. (See symbol in text) in early modern discussions of the passions: Stoicism, Christianity and natural history.

    Science.gov (United States)

    Kraye, Jill

    2012-01-01

    This paper examines the reception of the Stoic theory of the passions in the early modern period, highlighting various differences between the way notions such as (see symbol in text) (complete freedom from passions) and(see symbol in text) (pre-passions) were handled and interpreted by Continental and English authors. Both groups were concerned about the compatibility of Stoicism with Christianity, but came to opposing conclusions; and while the Continental scholars drew primarily on ancient philosophical texts, the English ones relied, in addition, on experience and observation, developing a natural history of the passions.

  18. Early history of Earth's crust-mantle system inferred from hafnium isotopes in chondrites

    DEFF Research Database (Denmark)

    Bizzarro, Martin; Haack, Henning; Rosing, M.

    2003-01-01

    for the chondrite-forming event. This ¿176 value indicates that Earth's oldest minerals were derived from melts of a mantle source with a time-integrated history of depletion rather than enrichment. The depletion event must have occurred no later than 320 Myr after planetary accretion, consistent with timing......The Lu to Hf decay series has been widely used to understand the nature of Earth's early crust-mantle system. The interpretation, however, of Lu-Hf isotope data requires accurate knowledge of the radioactive decay constant of Lu (¿176), as well as bulk-Earth reference parameters. A recent...

  19. Early history of inflatable penile prosthesis surgery: a view from someone who was there

    Directory of Open Access Journals (Sweden)

    David F Mobley

    2015-04-01

    Full Text Available The publication of the use of an inflatable penile prosthesis (IPP in 1973 by Dr. FB Scott. changed the world of treatment options for erectile dysfunction (ED. Much has been written since then about techniques, improvements, management of difficult cases, complications and their management, and mechanical and device changes over time. Few reports, if any, are available in the medical literature regarding the early development, surgical techniques, and controversies surrounding its introduction to the world's urological community. This article is, for the most part, the observations of one who was "there" in the early and mid-1970's and was a witness to the history of this remarkable marvel of creativity, engineering, design, and to the personalities involved.

  20. Taming the unknown a history of algebra from antiquity to the early twentieth century

    CERN Document Server

    Katz, Victor J

    2014-01-01

    What is algebra? For some, it is an abstract language of x's and y's. For mathematics majors and professional mathematicians, it is a world of axiomatically defined constructs like groups, rings, and fields. Taming the Unknown considers how these two seemingly different types of algebra evolved and how they relate. Victor Katz and Karen Parshall explore the history of algebra, from its roots in the ancient civilizations of Egypt, Mesopotamia, Greece, China, and India, through its development in the medieval Islamic world and medieval and early modern Europe, to its modern form in the early twentieth century. Defining algebra originally as a collection of techniques for determining unknowns, the authors trace the development of these techniques from geometric beginnings in ancient Egypt and Mesopotamia and classical Greece. They show how similar problems were tackled in Alexandrian Greece, in China, and in India, then look at how medieval Islamic scholars shifted to an algorithmic stage, which was further dev...

  1. Globalising Early Childhood Teacher Education: A Study of Student Life Histories and Course Experience in Teacher Education

    Science.gov (United States)

    Farell, Ann

    2005-01-01

    Globalisation in early childhood teacher education is examined in light of a study of the life histories and course experience of students in early childhood teacher education in Queensland, Australia. Contemporary teacher education is embedded in global economies, new technologies and marketisation, which, in turn, may contribute to students…

  2. Early thermal history of Rhea: the role of serpentinization and liquid state convection

    Science.gov (United States)

    Czechowski, Leszek; Losiak, Anna

    2015-04-01

    SSC is modelled simply by multiplying the coefficient of the heat conduction in the considered layer, i.e.: kconv =Nu k. This approach is used successfully in parameterized theory of convection for SSC in the Earth and other planets (e.g. [3], [4]). Parameterization of liquid state convection (LSC) is even simpler. Ra in molten region is very high (usually higher than 1016). The LSC could be very intensive resulting in almost adiabatic temperature gradient given by: dT-= gαmT-, dr cpm where αm and cpm are thermal expansion coefficient and specific heat in molten region, g is the local gravity. In Enceladus and Mimas the adiabatic gradient is low and therefore LSC region is almost isothermal. 2. Results: 1. We found that time of beginning of accretion and duration of accretion are crucial for early evolution, especially for differentiation. 2. Viscosity of ice close to melting point, activation energy in formula for viscosity E, and ammonia content X are very important for evolution, but not dramatic differences are found if realistic values are considered. 3. The energy of serpentinization is important for evolution, but its role is also not dominant. 4. LSC operating in molten part could delay the differentiation and the core formation for a few hundreds Myr. 5. The gravity data could be interpreted that Rhea is fully differentiated only if its core has high porosity and low density ~1300 kg m-3. In fact, there is not mechanism that could remove the water from molten core and the core of Rhea is probably porous. Acknowledgements: The research is partly supported by National Science Centre (grant 2011/ 01/ B/ ST10/06653). References : [1] Czechowski, L. (2014) Some remarks on the early evolution of Enceladus. Planet. Sp. Sc. 104, 185-199. [2] Merk, R., Breuer, D., Spohn, T. (2002). Numerical modeling of 26Al induced radioactive melting of asteroids concerning accretion. Icarus 199, 183-191. [3] Sharpe, H.N., Peltier, W.R., (1978) Parameterized mantle convection and

  3. Variations in early life history traits of Japanese anchovy Engraulis japonicus in the Yangtze River Estuary.

    Science.gov (United States)

    Liu, Chunlong; Xian, Weiwei; Liu, Shude; Chen, Yifeng

    2018-01-01

    Resources of Japanese anchovy ( Engraulis japonicus Temminck & Schlegel, 1846) are undergoing dramatic recessions in China as the consequence of intensifying anthropogenic activities. Elucidating the influences of local-scale environmental factors on early life history traits is of great importance to design strategies conserving and restoring the declining anchovy resources. In this research, we studied hatching date and early growth of anchovy in the Yangtze River Estuary (YRE) using information obtained from otolith microstructure. Onset of hatching season and growth rates of anchovy was compared to populations in Japan and Taiwan. In YRE, the hatching date of anchovy ranged from February 26th to April 6th and mean growth rate ranged from 0.27 to 0.77 mm/d. Anchovies hatching later had higher growth rates than individuals hatching earlier before the 25th day. Among populations, hatching onsets of anchovy from the higher latitude were later than populations in the lower latitude, and growth rates of anchovy in YRE were much lower than populations in Japan and Taiwan. Variations in hatching onsets and early growth patterns of anchovy thus provide important knowledge on understanding the adaptation of anchovy in YRE and designing management strategies on conserving China's anchovy resources.

  4. Energetic endpoints provide early indicators of life history effects in a freshwater gastropod exposed to the fungicide, pyraclostrobin.

    Science.gov (United States)

    Fidder, Bridgette N; Reátegui-Zirena, Evelyn G; Olson, Adric D; Salice, Christopher J

    2016-04-01

    Organismal energetics provide important insights into the effects of environmental toxicants. We aimed to determine the effects of pyraclostrobin on Lymnaea stagnalis by examining energy allocation patterns and life history traits. Juvenile snails exposed to pyraclostrobin decreased feeding rate and increased apparent avoidance behaviors at environmentally relevant concentrations. In adults, we found that sublethal concentrations of pyraclostrobin did not affect reproductive output, however, there were significant effects on developmental endpoints with longer time to hatch and decreased hatching success in pyraclostrobin-exposed egg masses. Further, there were apparent differences in developmental effects depending on whether mothers were also exposed to pyraclostrobin suggesting this chemical can exert intergenerational effects. Pyraclostrobin also affected protein and carbohydrate content of eggs in mothers that were exposed to pyraclostrobin. Significant effects on macronutrient content of eggs occurred at lower concentrations than effects on gross endpoints such as hatching success and time to hatch suggesting potential value for these endpoints as early indicators of ecologically relevant stress. These results provide important insight into the effects of a common fungicide on important endpoints for organismal energetics and life history. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Some consequences of a liquid water saturated regolith in early Martian history

    Science.gov (United States)

    Fuller, A. O.; Hargraves, R. B.

    1978-01-01

    Flooding of low-lying areas of the Martian regolith may have occurred early in the planet's history when a comparatively dense primitive atmosphere existed. If this model is valid, the following are some pedogenic and mineralogical consequences to be expected. Fluctuation of the water table in response to any seasonal or longer term causes would have resulted in precipitation of ferric oxyhydroxides with the development of a vesicular duricrust (or hardpan). Disruption of such a crust by scarp undercutting or frost heaving accompanied by wind deflation of fines could account for the boulders visible on Utopia Planitia in the vicinity of the second Viking lander site. Laboratory and field evidence on earth suggests that under weakly oxidizing conditions lepidocrocite (rather than goethite) would have preferentially formed in the Martian regolith from the weathering of ferrous silicates, accompanied by montmorillonite, nontronite, and cronstedtite. Maghemite may have formed as a low-temperature dehydrate of lepidocrocite or directly from ferrous precursors.

  6. A history of the early days of personality testing in American industry: an obsession with adjustment.

    Science.gov (United States)

    Gibby, Robert E; Zickar, Michael J

    2008-08-01

    Objective personality testing began with Woodworth's Personal Data Sheet in 1917. That test was developed to identify soldiers prone to nervous breakdowns during enemy bombardment in World War I (WWI). Soon after, many competing personality tests were developed for use in industry. Many of these tests, like Woodworth's, focused on the construct of employee maladjustment and were deemed important in screening out applicants who would create workplace disturbances. In this article, the authors review the history of these early personality tests, especially the Bernreuter Personality Inventory and the Humm-Wadsworth Temperament Scale, and discuss the implications of personality testers' obsession with the construct of employee maladjustment. In addition, the authors discuss the industry's obsession with emotional maladjustment and how this obsession coincided with a cultural shift in norms relating to cultural expression.

  7. DNA fingerprinting on trial: the dramatic early history of a new forensic technique.

    Science.gov (United States)

    Aronson, Jay D

    2005-09-01

    The early history of "DNA fingerprinting" in the UK might have been different were it not for the accounts of two dramatic courtroom trials, made by the participants and the media, in the mid-1980s. But these reports, which misrepresented the importance DNA evidence had in the trials, left a strong impression on the British public and on judges on both sides of the Atlantic. These trials, widely considered to be the first "victories" for DNA fingerprinting, have been frequently cited as proof of the utility and reliability of the technique, in both the UK and beyond. But in reality, it was the threat of DNA evidence being used rather than the integrity or validity of it that resolved these cases. At that time, DNA fingerprinting was still in its infancy, an untried and untested technology.

  8. Early tectonic history of the Marymia Inlier and correlation with the Archaean Yilgarn Craton, Western Australia

    International Nuclear Information System (INIS)

    Bagas, L.

    1999-01-01

    The Archaean granite-greenstone rocks of the Marymia Inlier outcrop within Proterozoic rocks forming the Capricorn Orogen. Five major deformation events are recognised in the rocks of the Plutonic Well and Baumgarten greenstone belts. The first two events were Late Archaean and synchronous with major epithermal gold mineralisation in the belts. Palaeoproterozoic extensional faulting was probably related to the early stages of the Capricorn Orogeny. The fourth event records a compressional phase of the Capricorn Orogeny associated with greenschist-facies metamorphism, whereas the last major event involved wrench faulting associated with minor folding. The Archaean tectonic history, rock types and timing of mineralisation strongly suggest that the Marymia Inlier is part of the Yilgarn Craton, and that each of the provinces in the craton experienced the same geological history since 2.72 Ga. The inlier is now interpreted to include two components, one is the eastern or northern extension of either the Narryer Terrane. Murchison Province or Southern Cross Province, and the other is the northwestern extension of the Eastern Goldfields Province. The Jenkin Fault, which was active in Proterozoic times, separates these two components. Copyright (1999) Blackwell Science Pty Ltd

  9. Earliest evidence of modern human life history in North African early Homo sapiens.

    Science.gov (United States)

    Smith, Tanya M; Tafforeau, Paul; Reid, Donald J; Grün, Rainer; Eggins, Stephen; Boutakiout, Mohamed; Hublin, Jean-Jacques

    2007-04-10

    Recent developmental studies demonstrate that early fossil hominins possessed shorter growth periods than living humans, implying disparate life histories. Analyses of incremental features in teeth provide an accurate means of assessing the age at death of developing dentitions, facilitating direct comparisons with fossil and modern humans. It is currently unknown when and where the prolonged modern human developmental condition originated. Here, an application of x-ray synchrotron microtomography reveals that an early Homo sapiens juvenile from Morocco dated at 160,000 years before present displays an equivalent degree of tooth development to modern European children at the same age. Crown formation times in the juvenile's macrodont dentition are higher than modern human mean values, whereas root development is accelerated relative to modern humans but is less than living apes and some fossil hominins. The juvenile from Jebel Irhoud is currently the oldest-known member of Homo with a developmental pattern (degree of eruption, developmental stage, and crown formation time) that is more similar to modern H. sapiens than to earlier members of Homo. This study also underscores the continuing importance of North Africa for understanding the origins of human anatomical and behavioral modernity. Corresponding biological and cultural changes may have appeared relatively late in the course of human evolution.

  10. REVERSAL OF FORTUNE: INCREASED STAR FORMATION EFFICIENCIES IN THE EARLY HISTORIES OF DWARF GALAXIES?

    International Nuclear Information System (INIS)

    Madau, Piero; Weisz, Daniel R.; Conroy, Charlie

    2014-01-01

    On dwarf galaxy scales, the different shapes of the galaxy stellar mass function and the dark halo mass function require a star-formation efficiency (SFE) in these systems that is currently more than 1 dex lower than that of Milky Way-size halos. Here, we argue that this trend may actually be reversed at high redshift. Specifically, by combining the resolved star-formation histories of nearby isolated dwarfs with the simulated mass-growth rates of dark matter halos, we show that the assembly of these systems occurs in two phases: (1) an early, fast halo accretion phase with a rapidly deepening potential well, characterized by a high SFE; and (2) a late, slow halo accretion phase where, perhaps as a consequence of reionization, the SFE is low. Nearby dwarfs have more old stars than predicted by assuming a constant or decreasing SFE with redshift, a behavior that appears to deviate qualitatively from the trends seen among more massive systems. Taken at face value, the data suggest that at sufficiently early epochs, dwarf galaxy halos above the atomic cooling mass limit can be among the most efficient sites of star formation in the universe

  11. Diagenetic history of late Oligocene-early Miocene carbonates in East Sabah, Malaysia

    Science.gov (United States)

    Zainal Abidin, N. S.; Raymond, R. R.; Bashah, N. S. I.

    2017-10-01

    Limestones are particularly susceptible to drastic early diagenesis modifications, mainly cementation and dissolution. During the early Miocene, a major tectonic deformation has caused a widespread of uplift in Sabah. This has resulted change in depositional environment from deep to shallow marine, which favours the deposition of Gomantong Limestone. This study aims to investigate the diagenetic history of Gomantong Limestone in East Sabah. Thorough understanding of the diagenetic processes may provide data to unravel the tectonic activities which affected the reservoir quality of the carbonates. Combining the data from comprehensive petrographic analysis, and Scanning Electron Microscopy (SEM) of 30 samples, two main cements type were identified. These are microcrystalline cement and Mg-calcite cement of granular and blocky mosaics which are dominantly seen in all samples. The sequence of diagenesis events are determined as (1) micritization; (2) grain scale compaction; (3) cementation (pore-filling); (4) mechanical compaction and cementation infilling fractures and (5) chemical compaction. These diagenetic events are interpreted as reflection of changes in diagenetic environment from shallow marine to deep burial. The massive cementation in the Gomantong Limestone has resulted into a poor reservoir quality.

  12. Reversal of Fortune: Increased Star Formation Efficiencies in the Early Histories of Dwarf Galaxies?

    Science.gov (United States)

    Madau, Piero; Weisz, Daniel R.; Conroy, Charlie

    2014-08-01

    On dwarf galaxy scales, the different shapes of the galaxy stellar mass function and the dark halo mass function require a star-formation efficiency (SFE) in these systems that is currently more than 1 dex lower than that of Milky Way-size halos. Here, we argue that this trend may actually be reversed at high redshift. Specifically, by combining the resolved star-formation histories of nearby isolated dwarfs with the simulated mass-growth rates of dark matter halos, we show that the assembly of these systems occurs in two phases: (1) an early, fast halo accretion phase with a rapidly deepening potential well, characterized by a high SFE; and (2) a late, slow halo accretion phase where, perhaps as a consequence of reionization, the SFE is low. Nearby dwarfs have more old stars than predicted by assuming a constant or decreasing SFE with redshift, a behavior that appears to deviate qualitatively from the trends seen among more massive systems. Taken at face value, the data suggest that at sufficiently early epochs, dwarf galaxy halos above the atomic cooling mass limit can be among the most efficient sites of star formation in the universe.

  13. Time development in the early history of social networks: link stabilization, group dynamics, and segregation.

    Science.gov (United States)

    Bruun, Jesper; Bearden, Ian G

    2014-01-01

    Studies of the time development of empirical networks usually investigate late stages where lasting connections have already stabilized. Empirical data on early network history are rare but needed for a better understanding of how social network topology develops in real life. Studying students who are beginning their studies at a university with no or few prior connections to each other offers a unique opportunity to investigate the formation and early development of link patterns and community structure in social networks. During a nine week introductory physics course, first year physics students were asked to identify those with whom they communicated about problem solving in physics during the preceding week. We use these students' self reports to produce time dependent student interaction networks. We investigate these networks to elucidate possible effects of different student attributes in early network formation. Changes in the weekly number of links show that while roughly half of all links change from week to week, students also reestablish a growing number of links as they progress through their first weeks of study. Using the Infomap community detection algorithm, we show that the networks exhibit community structure, and we use non-network student attributes, such as gender and end-of-course grade to characterize communities during their formation. Specifically, we develop a segregation measure and show that students structure themselves according to gender and pre-organized sections (in which students engage in problem solving and laboratory work), but not according to end-of-coure grade. Alluvial diagrams of consecutive weeks' communities show that while student movement between groups are erratic in the beginning of their studies, they stabilize somewhat towards the end of the course. Taken together, the analyses imply that student interaction networks stabilize quickly and that students establish collaborations based on who is immediately

  14. Dissolved Massive Metal-rich Globular Clusters Can Cause the Range of UV Upturn Strengths Found among Early-type Galaxies

    Science.gov (United States)

    Goudfrooij, Paul

    2018-04-01

    I discuss a scenario in which the ultraviolet (UV) upturn of giant early-type galaxies (ETGs) is primarily due to helium-rich stellar populations that formed in massive metal-rich globular clusters (GCs), which subsequently dissolved in the strong tidal field in the central regions of the massive host galaxy. These massive GCs are assumed to show UV upturns similar to those observed recently in M87, the central giant elliptical galaxy in the Virgo cluster of galaxies. Data taken from the literature reveal a strong correlation between the strength of the UV upturn and the specific frequency of metal-rich GCs in ETGs. Adopting a Schechter function parameterization of GC mass functions, simulations of long-term dynamical evolution of GC systems show that the observed correlation between UV upturn strength and GC specific frequency can be explained by variations in the characteristic truncation mass {{ \\mathcal M }}{{c}} such that {{ \\mathcal M }}{{c}} increases with ETG luminosity in a way that is consistent with observed GC luminosity functions in ETGs. These findings suggest that the nature of the UV upturn in ETGs and the variation of its strength among ETGs are causally related to that of helium-rich populations in massive GCs, rather than intrinsic properties of field stars in massive galactic spheroids. With this in mind, I predict that future studies will find that [N/Fe] decreases with increasing galactocentric radius in massive ETGs, and that such gradients have the largest amplitudes in ETGs with the strongest UV upturns.

  15. Technological and organizational diversity and technical advance in the early history of the American semiconductor industry

    Science.gov (United States)

    Cohen, W.; Holbrook, D.; Klepper, S.

    1994-06-01

    This study examines the early years of the semiconductor industry and focuses on the roles played by different size firms in technologically innovative processes. A large and diverse pool of firms participated in the growth of the industry. Three related technological areas were chosen for in-depth analysis: integrated circuits, materials technology, and device packaging. Large business producing vacuum tubes dominated the early production of semiconductor devices. As the market for new devices grew during the 1950's, new firms were founded and existing firms from other industries, e.g. aircraft builders and instrument makers, began to pursue semiconductor electronics. Small firms began to cater to the emerging industry by supplying materials and equipment. These firms contributed to the development of certain aspects of one thousand firms that were playing some part in the semiconductor industry.

  16. Who are the early adopters of car sharing? A brief history and an analysis of the early adoption of car sharing in Denmark

    DEFF Research Database (Denmark)

    Thøgersen, John; Norre, Lise

    1999-01-01

    After briefly outlining the context, focusing primarily on the economic conditions for car sharing and on the history of the first car sharing initiatives in Denmark, this paper presents results from a study of the early adopters of the car sharing idea in Denmark and some speculations about...... the future of car sharing in this country....

  17. Evidence of late-summer mating readiness and early sexual maturation in migratory tree-roosting bats found dead at wind turbines

    Science.gov (United States)

    Cryan, P.M.; Jameson, J.W.; Baerwald, E.F.; Willis, C.K.R.; Barclay, R.M.R.; Snider, E.A.; Crichton, E.G.

    2012-01-01

    Understanding animal mating systems is an important component of their conservation, yet the precise mating times for many species of bats are unknown. The aim of this study was to better understand the details and timing of reproductive events in species of bats that die most frequently at wind turbines in North America, because such information can help inform conservation strategies. We examined the reproductive anatomy of hoary bats (Lasiurus cinereus), eastern red bats (L. borealis), and silver-haired bats (Lasionycteris noctivagans) found dead beneath industrial-scale wind turbines to learn more about when they mate. We evaluated 103 L. cinereus, 18 L. borealis, and 47 Ln. noctivagans from wind energy facilities in the United States and Canada. Histological analysis revealed that most male L. cinereus and L. borealis, as well as over half the Ln. noctivagans examined had sperm in the caudae epididymides by late August, indicating readiness to mate. Testes regression in male hoary bats coincided with enlargement of seminal vesicles and apparent growth of keratinized spines on the glans penis. Seasonality of these processes also suggests that mating could occur during August in L. cinereus. Spermatozoa were found in the uterus of an adult female hoary bat collected in September, but not in any other females. Ovaries of all females sampled had growing secondary or tertiary follicles, indicating sexual maturity even in first-year females. Lasiurus cinereus, L. borealis, and Ln. noctivagans are the only North American temperate bats in which most first-year young of both sexes are known to sexually mature in their first autumn. Our findings provide the first detailed information published on the seasonal timing of mating readiness in these species most affected by wind turbines.

  18. Evidence of late-summer mating readiness and early sexual maturation in migratory tree-roosting bats found dead at wind turbines.

    Directory of Open Access Journals (Sweden)

    Paul M Cryan

    Full Text Available Understanding animal mating systems is an important component of their conservation, yet the precise mating times for many species of bats are unknown. The aim of this study was to better understand the details and timing of reproductive events in species of bats that die most frequently at wind turbines in North America, because such information can help inform conservation strategies. We examined the reproductive anatomy of hoary bats (Lasiurus cinereus, eastern red bats (L. borealis, and silver-haired bats (Lasionycteris noctivagans found dead beneath industrial-scale wind turbines to learn more about when they mate. We evaluated 103 L. cinereus, 18 L. borealis, and 47 Ln. noctivagans from wind energy facilities in the United States and Canada. Histological analysis revealed that most male L. cinereus and L. borealis, as well as over half the Ln. noctivagans examined had sperm in the caudae epididymides by late August, indicating readiness to mate. Testes regression in male hoary bats coincided with enlargement of seminal vesicles and apparent growth of keratinized spines on the glans penis. Seasonality of these processes also suggests that mating could occur during August in L. cinereus. Spermatozoa were found in the uterus of an adult female hoary bat collected in September, but not in any other females. Ovaries of all females sampled had growing secondary or tertiary follicles, indicating sexual maturity even in first-year females. Lasiurus cinereus, L. borealis, and Ln. noctivagans are the only North American temperate bats in which most first-year young of both sexes are known to sexually mature in their first autumn. Our findings provide the first detailed information published on the seasonal timing of mating readiness in these species most affected by wind turbines.

  19. Evidence of late-summer mating readiness and early sexual maturation in migratory tree-roosting bats found dead at wind turbines.

    Science.gov (United States)

    Cryan, Paul M; Jameson, Joel W; Baerwald, Erin F; Willis, Craig K R; Barclay, Robert M R; Snider, E Apple; Crichton, Elizabeth G

    2012-01-01

    Understanding animal mating systems is an important component of their conservation, yet the precise mating times for many species of bats are unknown. The aim of this study was to better understand the details and timing of reproductive events in species of bats that die most frequently at wind turbines in North America, because such information can help inform conservation strategies. We examined the reproductive anatomy of hoary bats (Lasiurus cinereus), eastern red bats (L. borealis), and silver-haired bats (Lasionycteris noctivagans) found dead beneath industrial-scale wind turbines to learn more about when they mate. We evaluated 103 L. cinereus, 18 L. borealis, and 47 Ln. noctivagans from wind energy facilities in the United States and Canada. Histological analysis revealed that most male L. cinereus and L. borealis, as well as over half the Ln. noctivagans examined had sperm in the caudae epididymides by late August, indicating readiness to mate. Testes regression in male hoary bats coincided with enlargement of seminal vesicles and apparent growth of keratinized spines on the glans penis. Seasonality of these processes also suggests that mating could occur during August in L. cinereus. Spermatozoa were found in the uterus of an adult female hoary bat collected in September, but not in any other females. Ovaries of all females sampled had growing secondary or tertiary follicles, indicating sexual maturity even in first-year females. Lasiurus cinereus, L. borealis, and Ln. noctivagans are the only North American temperate bats in which most first-year young of both sexes are known to sexually mature in their first autumn. Our findings provide the first detailed information published on the seasonal timing of mating readiness in these species most affected by wind turbines.

  20. Mechanisms of Egg Yolk Formation and Implications on Early Life History of White Perch (Morone americana.

    Directory of Open Access Journals (Sweden)

    Justin Schilling

    late stage fish larvae prior to the onset of exogenous feeding and its composition in the egg yolk may relate to different early life histories among this diverse group of animals.

  1. CO2-level Dependent Effects of Ocean Acidification on Squid, Doryteuthis pealeii, Early Life History

    KAUST Repository

    Zakroff, Casey J.

    2013-12-01

    Ocean acidification is predicted to lead to global oceanic decreases in pH of up to 0.3 units within the next 100 years. However, those levels are already being reached currently in coastal regions due to natural CO2 variability. Squid are a vital component of the pelagic ecosystem, holding a unique niche as a highly active predatory invertebrate and major prey stock for upper trophic levels. This study examined the effects of a range of ocean acidification regimes on the early life history of a coastal squid species, the Atlantic longfin squid, Doryteuthis pealeii. Eggs were raised in a flow-through ocean acidification system at CO2 levels ranging from ambient (400ppm) to 2200ppm. Time to hatching, hatching efficiency, and hatchling mantle lengths, yolk sac sizes, and statoliths were all examined to elucidate stress effects. Delays in hatching time of at least a day were seen at exposures above 1300ppm in all trials under controlled conditions. Mantle lengths were significantly reduced at exposures above 1300 ppm. Yolk sac sizes varied between CO2 treatments, but no distinct pattern emerged. Statoliths were increasingly porous and malformed as CO2 exposures increased, and were significantly reduced in surface area at exposures above 1300ppm. Doryteuthis pealeii appears to be able to withstand acidosis stress without major effects up to 1300ppm, but is strongly impacted past that threshold. Since yolk consumption did not vary among treatments, it appears that during its early life stages, D. pealeii reallocates its available energy budget away from somatic growth and system development in order to mitigate the stress of acidosis.

  2. Bipolar affective disorder and borderline personality disorder: Differentiation based on the history of early life stress and psychoneuroendocrine measures.

    Science.gov (United States)

    Mazer, Angela Kaline; Cleare, Anthony J; Young, Allan H; Juruena, Mario F

    2018-04-24

    neglect. A significant negative correlation between the severity of hopelessness vs cortisol; and physical neglect vs cortisol were found in BPD with ELS. The single cortisol sample showed a significant and opposite correlations in the sexual abuse diagnosis-related groups, being a negative correlation in BD and positive in BPD. Considering the need for a multi-factorial analysis, the differential diagnosis between BPD and BD can be facilitated by the study of psychiatric symptoms, which is more severe in the BPD patients with a history of early life stress. The function of the HPA axis assessed by this cortisol measure suggests differences between BPD and BP with ELS history. The integrated analysis of psychopathology, ELS and neuroendocrine function may provide useful indicators to differentiate BPD and BD diagnoses. These preliminary data need to be replicated in a more significant sample with a better assessment and multiple assessments of the HPA axis activity. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. The wondrous eyes of a new technology : A history of the early electroencephalography (EEG) of psychopathy, delinquency, and immorality

    NARCIS (Netherlands)

    Schirmann, Felix

    2014-01-01

    This article presents a history of the early electroencephalography (EEG) of psychopathy, delinquency, and immorality in Great Britain and the United States in the 1940s and 1950s. Then, EEG was a novel research tool that promised ground-breaking insights in psychiatry and criminology. Experts

  4. The relevance of the early history of probability theory to current risk assessment practices in mental health care.

    Science.gov (United States)

    Large, Matthew

    2013-12-01

    Probability theory is at the base of modern concepts of risk assessment in mental health. The aim of the current paper is to review the key developments in the early history of probability theory in order to enrich our understanding of current risk assessment practices.

  5. Early germs of quantum field theory in the history of quantum physics

    International Nuclear Information System (INIS)

    Hund, F.

    1983-01-01

    The main concepts of quantum electrodynamics: duality of fields and particles, field quanta, antiparticles, creation and annihilation of particles, reactions based on a coupling, these concepts are common for all quantum field theory. Roots and germs of them we find already in the early history of quantum physics. Up to creation and physical understanding of quantum mechanics (1927) we can distinguish three steps. The first, ranging from black body radiation to specific heat (1900-1913) was essentially low temperature physics; h became the natural unity for counting cases in statistics. The second step was search for atomic mechanics (19131925): it was guided by a special law of atomic spectra, the combination principle ν=F (n,1...) - F (n',1'...); The third step (1923-1927), De Broglie's transfer of duality from light to matter, Schrodinger's equation, the concept of probability amplitudes, led to a general mathematical formalism and its physical understanding. During the first of these historical steps duality of light was detected and a sort of quantization of the light field took place; during the second step this duality remained in the background; during the third step duality of light and matter were seen as the center of quantum physics

  6. Evolutionary demography and the population history of the European early Neolithic.

    Science.gov (United States)

    Shennan, Stephen

    2009-04-01

    In this paper I propose that evolutionary demography and associated theory from human behavioral ecology provide a strong basis for explaining the available evidence for the patterns observed in the first agricultural settlement of Europe in the 7th-5th millennium cal. BC, linking together a variety of what have previously been disconnected observations and casting doubt on some long-standing existing models. An outline of relevant aspects of life history theory, which provides the foundation for understanding demography, is followed by a review of large-scale demographic patterns in the early Neolithic, which point to rapid population increase and a process of demic diffusion. More localized socioeconomic and demographic patterns suggesting rapid expansion to local carrying capacities and an associated growth of inequality in the earliest farming communities of central Europe (the Linear Pottery Culture, or LBK) are then outlined and shown to correspond to predictions of spatial population ecology and reproductive skew theory. Existing models of why it took so long for farming to spread to northern and northwest Europe, which explain the spread in terms of the gradual disruption of hunter-gatherer ways of life, are then questioned in light of evidence for population collapse at the end of the LBK. Finally, some broader implications of the study are presented, including the suggestion that the pattern of an initial agricultural boom followed by a bust may be relevant in other parts of the world.

  7. Cosmic reionization on computers. II. Reionization history and its back-reaction on early galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Gnedin, Nickolay Y. [Particle Astrophysics Center, Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States); Kaurov, Alexander A., E-mail: gnedin@fnal.gov, E-mail: kaurov@uchicago.edu [Department of Astronomy and Astrophysics, The University of Chicago, Chicago, IL 60637 (United States)

    2014-09-20

    We compare the results from several sets of cosmological simulations of cosmic reionization, produced under the Cosmic Reionization On Computers project, with existing observational data on the high-redshift Lyα forest and the abundance of Lyα emitters. We find good consistency with the observational measurements and previous simulation work. By virtue of having several independent realizations for each set of numerical parameters, we are able to explore the effect of cosmic variance on observable quantities. One unexpected conclusion we are forced into is that cosmic variance is unusually large at z > 6, with both our simulations and, most likely, observational measurements still not fully converged for even such basic quantities as the average Gunn-Peterson optical depth or the volume-weighted neutral fraction. We also find that reionization has little effect on the early galaxies or on global cosmic star formation history, because galaxies whose gas content is affected by photoionization contain no molecular (i.e., star-forming) gas in the first place. In particular, measurements of the faint end of the galaxy luminosity function by the James Webb Space Telescope are unlikely to provide a useful constraint on reionization.

  8. Captive propagation, reproductive biology, and early life history of the Diamond Darter (Crystallaria cincotta)

    Science.gov (United States)

    Ruble, Crystal L.; Rakes, Patrick L.; Shute, John R.; Welsh, Stuart A.

    2014-01-01

    Reproductive biology and early life history data are critical for the conservation and management of rare fishes. During 2008–2012 a captive propagation study was conducted on the Diamond Darter, Crystallaria cincotta, a rare species with a single extant population in the lower Elk River, West Virginia. Water temperatures during spawning ranged from 11.1–23.3 C. Females and males spawned with quick vibrations, burying eggs in fine sand in relatively swift clean depositional areas. Egg size was 1.8–1.9 mm, and embryos developed within 7 to 11 d. Diamond Darters were 6.7–7.2 mm total length (TL) at hatch. Larvae ranged from 9.0–11.0 mm TL following a 5–10 d period of yolk sac absorption. Larvae had relatively large mouth gapes and teeth and were provided brine shrimp Artemia sp., Ceriodaphnia dubia neonates, marine Brachionus rotifers, and powdered foods (50–400 µm) but did not appear to feed in captivity, except for one observation of larval cannibalization. Larvae survived for a maximum of 10 d. To increase larval survival and reduce the possibility of cannibalism, other alternative food sources are needed during captive propagation.

  9. Constraints on early events in Martian history as derived from the cratering record

    International Nuclear Information System (INIS)

    Barlow, N.G.

    1990-01-01

    The shapes and densities of crater size-frequency distribution curves are used to constrain two major events early in Martian history: termination of high obliteration rates and viability of the multiple impact origin of the crustal dichotomy. Distribution curves of fresh craters superposed on uplands, intercrater plains, and ridged plains display shapes and densities indicative of formation prior to the end of heavy bombardment. This observation correlates with other geologic evidence, suggesting a major change in the erosional regime following the last major basin size impact (i.e., Argrye). In addition, the multisloped nature of the curves supports the idea that the downturn in the crater size-frequency distribution curves reflects the size-frequency distribution of the impactors rather than being the result of erosion. The crustal dichotomy formed prior to the heavy bombardment intermediate epoch based on distribution curves of knobby terrain; if the dichotomy resulted from a single gigantic impact, this observation places constraints on when this event happened. An alternate theory for dichotomy formation, the multiple-impact basin idea, is questioned: since distribution curves of large basins as well as heavy bombardment era units are not represented by a -3 differential power law function, this study finds fewer basins missing on Mars compare to the Moon and Mercury than previously reported. The area covered by these missing basins is less than that covered the northern plains

  10. Effects of the herbicide diuron on the early life history stages of coral

    Energy Technology Data Exchange (ETDEWEB)

    Negri, Andrew [Australian Institute of Marine Science, PMB 3 Townsville, QLD 4810 (Australia)]. E-mail: a.negri@aims.gov.au; Vollhardt, Claudia [Australian Institute of Marine Science, PMB 3 Townsville, QLD 4810 (Australia); Humphrey, Craig [Australian Institute of Marine Science, PMB 3 Townsville, QLD 4810 (Australia); Heyward, Andrew [Australian Institute of Marine Science, PMB 3 Townsville, QLD 4810 (Australia); Jones, Ross [Centre for Marine Studies, University of Queensland, St Lucia, QLD 4072 (Australia); Queensland Health Scientific Services, 39 Kessels Road, Coopers Plains 4108 (Australia); Eaglesham, Geoff [Bermuda Biological Station for Research, Inc, Ferry Reach, St George' s GE 01 (Bermuda); Fabricius, Katharina [Australian Institute of Marine Science, PMB 3 Townsville, QLD 4810 (Australia)

    2005-07-01

    The effects of the herbicide diuron on the early life history stages of broadcast spawning and brooding corals were examined in laboratory experiments. Fertilisation of Acropora millepora and Montipora aequituberculata oocytes were not inhibited at diuron concentrations of up to 1000{mu}gl{sup -1}. Metamorphosis of symbiont-free A. millepora larvae was only significantly inhibited at 300{mu}gl{sup -1} diuron. Pocillopora damicornis larvae, which contain symbiotic dinoflagellates, were able to undergo metamorphosis after 24h exposure to diuron at 1000{mu}gl{sup -1}. Two-week old P. damicornis recruits on the other hand were as susceptible to diuron as adult colonies, with expulsion of symbiotic dinoflagellates (bleaching) evident at 10{mu}gl{sup -1} diuron after 96h exposure. Reversible metamorphosis was observed at high diuron concentrations, with fully bleached polyps escaping from their skeletons. Pulse amplitude modulation (PAM) chlorophyll fluorescence techniques demonstrated a reduction in photosynthetic efficiency ({delta}F/F{sub m}{sup '}) in illuminated P. damicornis recruits after a 2h exposure to 1{mu}gl{sup -1} diuron. The dark-adapted quantum yields (F{sub v}/F{sub m}) also declined, indicating chronic photoinhibition and damage to photosystem II.

  11. Effects of the herbicide diuron on the early life history stages of coral

    International Nuclear Information System (INIS)

    Negri, Andrew; Vollhardt, Claudia; Humphrey, Craig; Heyward, Andrew; Jones, Ross; Eaglesham, Geoff; Fabricius, Katharina

    2005-01-01

    The effects of the herbicide diuron on the early life history stages of broadcast spawning and brooding corals were examined in laboratory experiments. Fertilisation of Acropora millepora and Montipora aequituberculata oocytes were not inhibited at diuron concentrations of up to 1000μgl -1 . Metamorphosis of symbiont-free A. millepora larvae was only significantly inhibited at 300μgl -1 diuron. Pocillopora damicornis larvae, which contain symbiotic dinoflagellates, were able to undergo metamorphosis after 24h exposure to diuron at 1000μgl -1 . Two-week old P. damicornis recruits on the other hand were as susceptible to diuron as adult colonies, with expulsion of symbiotic dinoflagellates (bleaching) evident at 10μgl -1 diuron after 96h exposure. Reversible metamorphosis was observed at high diuron concentrations, with fully bleached polyps escaping from their skeletons. Pulse amplitude modulation (PAM) chlorophyll fluorescence techniques demonstrated a reduction in photosynthetic efficiency (ΔF/F m ' ) in illuminated P. damicornis recruits after a 2h exposure to 1μgl -1 diuron. The dark-adapted quantum yields (F v /F m ) also declined, indicating chronic photoinhibition and damage to photosystem II

  12. Metamorphic history and geodynamic significance of the Early Cretaceous Sabzevar granulites (Sabzevar structural zone, NE Iran

    Directory of Open Access Journals (Sweden)

    M. Nasrabady

    2011-11-01

    Full Text Available The Iranian ophiolites are part of the vast orogenic suture zones that mark the Alpine-Himalayan convergence zone. Few petrological and geochronological data are available from these ophiolitic domains, hampering a full assessment of the timing and regimes of subduction zone metamorphism and orogenic construction in the region. This paper describes texture, geochemistry, and the pressure-temperature path of the Early Cretaceous mafic granulites that occur within the Tertiary Sabzevar ophiolitic suture zone of NE Iran. Whole rock geochemistry indicates that the Sabzevar granulites are likely derived from a MORB-type precursor. They are thus considered as remnants of a dismembered dynamo-thermal sole formed during subduction of a back-arc basin (proto-Sabzevar Ocean formed in the upper-plate of the Neotethyan slab. The metamorphic history of the granulites suggests an anticlockwise pressure-temperature loop compatible with burial in a hot subduction zone, followed by cooling during exhumation. Transition from a nascent to a mature stage of oceanic subduction is the geodynamic scenario proposed to accomplish for the reconstructed thermobaric evolution. When framed with the regional scenario, results of this study point to diachronous and independent tectonic evolutions of the different ophiolitic domains of central Iran, for which a growing disparity in the timing of metamorphic equilibration and of pressure-temperature paths can be expected to emerge with further investigations.

  13. Early Depositional History of the Eocene Izu-Bonin Mariana Arc, Western Pacific Ocean

    Science.gov (United States)

    Waldman, R.; Marsaglia, K. M.; Tepley, F. J., III

    2015-12-01

    Expedition 351 of the International Ocean Discovery Program cored an Eocene section at Site U1438 in the Philippine Sea that provides insight into the early history of the Izu-Bonin arc. Subduction here is hypothesized to have initiated spontaneously, leaving a characteristic depositional sequence of post-subduction-initiation localized extension and volcanism. We conducted detailed macroscopic and microscopic study of the cores of the lowermost 100m of volcaniclastic and sedimentary rocks (Unit IV) directly overlying subduction initiation igneous basement, to identify depositional facies and trends. We subdivided Unit IV into three subunits based on lithologic characteristics. Transitions between the subunits are relatively abrupt, occurring within the length of a single core. The lowermost subunit (IVA) consists of 4 meters of laminated pelagic claystone with thin beds of graded volcaniclastic siltstone, and fine-grained tuff laminae composed of plagioclase feldspar and green-brown amphibole. The middle subunit (IVB) comprises 51 meters of texturally variable, thick-bedded, coarse-grained gravity flow deposits. These are composed of volcaniclastic sandstone and conglomerate containing glassy and tachylitic volcanic grains as well as sedimentary lithic fragments, along with traces of shallow-water carbonate bioclasts. Subunit IVB sediments are poorer in feldspar than IVA and contain only trace amphibole. They show variable grain rounding and an upsection increase in vitric components. Tachylite grains range from sub-angular to well rounded throughout, and other volcanic grain types show upward increases in angularity and vesicularity. The abrupt transition from pelagic sediments in subunit IVA to shallow-water-sourced gravity flows in subunit IVB suggests a rapid emergence of shallow-water to subaerial volcanic center early in the arc's development. The upper part of subunit IVB also contains igneous intrusions, providing possible evidence for more proximal

  14. Diverse Early Life-History Strategies in Migratory Amazonian Catfish: Implications for Conservation and Management.

    Directory of Open Access Journals (Sweden)

    Jens C Hegg

    Full Text Available Animal migrations provide important ecological functions and can allow for increased biodiversity through habitat and niche diversification. However, aquatic migrations in general, and those of the world's largest fish in particular, are imperiled worldwide and are often poorly understood. Several species of large Amazonian catfish carry out some of the longest freshwater fish migrations in the world, travelling from the Amazon River estuary to the Andes foothills. These species are important apex predators in the main stem rivers of the Amazon Basin and make up the region's largest fishery. They are also the only species to utilize the entire Amazon Basin to complete their life cycle. Studies indicate both that the fisheries may be declining due to overfishing, and that the proposed and completed dams in their upstream range threaten spawning migrations. Despite this, surprisingly little is known about the details of these species' migrations, or their life history. Otolith microchemistry has been an effective method for quantifying and reconstructing fish migrations worldwide across multiple spatial scales and may provide a powerful tool to understand the movements of Amazonian migratory catfish. Our objective was to describe the migratory behaviors of the three most populous and commercially important migratory catfish species, Dourada (Brachyplatystoma rousseauxii, Piramutaba (Brachyplatystoma vaillantii, and Piraíba (Brachyplatystoma filamentosum. We collected fish from the mouth of the Amazon River and the Central Amazon and used strontium isotope signatures ((87Sr/(86Sr recorded in their otoliths to determine the location of early rearing and subsequent. Fish location was determined through discriminant function classification, using water chemistry data from the literature as a training set. Where water chemistry data was unavailable, we successfully in predicted (87Sr/(86Sr isotope values using a regression-based approach that related

  15. Diverse Early Life-History Strategies in Migratory Amazonian Catfish: Implications for Conservation and Management.

    Science.gov (United States)

    Hegg, Jens C; Giarrizzo, Tommaso; Kennedy, Brian P

    2015-01-01

    Animal migrations provide important ecological functions and can allow for increased biodiversity through habitat and niche diversification. However, aquatic migrations in general, and those of the world's largest fish in particular, are imperiled worldwide and are often poorly understood. Several species of large Amazonian catfish carry out some of the longest freshwater fish migrations in the world, travelling from the Amazon River estuary to the Andes foothills. These species are important apex predators in the main stem rivers of the Amazon Basin and make up the region's largest fishery. They are also the only species to utilize the entire Amazon Basin to complete their life cycle. Studies indicate both that the fisheries may be declining due to overfishing, and that the proposed and completed dams in their upstream range threaten spawning migrations. Despite this, surprisingly little is known about the details of these species' migrations, or their life history. Otolith microchemistry has been an effective method for quantifying and reconstructing fish migrations worldwide across multiple spatial scales and may provide a powerful tool to understand the movements of Amazonian migratory catfish. Our objective was to describe the migratory behaviors of the three most populous and commercially important migratory catfish species, Dourada (Brachyplatystoma rousseauxii), Piramutaba (Brachyplatystoma vaillantii), and Piraíba (Brachyplatystoma filamentosum). We collected fish from the mouth of the Amazon River and the Central Amazon and used strontium isotope signatures ((87)Sr/(86)Sr) recorded in their otoliths to determine the location of early rearing and subsequent. Fish location was determined through discriminant function classification, using water chemistry data from the literature as a training set. Where water chemistry data was unavailable, we successfully in predicted (87)Sr/(86)Sr isotope values using a regression-based approach that related the geology

  16. Early Mongols – the Ethno-Political History to the 13th Century

    Directory of Open Access Journals (Sweden)

    Nenad Vidaković

    2015-04-01

    Full Text Available The paper examines the etnogenesis of the Mongol tribes from the period of the Rouran and Shiwei tribal alliances to the unification in the early 13th century under Genghis Khan’s leadership. The initial period of the ethnogenesis of medieval Mongols’ ancestors is associated with Rouran and Shiwei tribal alliances while news about them are written in Chinese dynastic chronicles. Within the Shiwei association there was the Mengwu tribe that inhabited forest expanses of north-western Manchuria, and the Argun river basin is considered to be the original homeland of the Mongols. The directions and time of migration processes which played an important role in the transformation of part of Mongol tribes from forest hunters to steppe nomads have been further investigated. The ethnic history of the Mongol tribes is closely associated with the Turkic and Tungus-Manchurian tribes. The Turkic tribes, that inhabited the steppes of Mongolia today, had a crucial importance in the development of Mongol nomadic tribes, while the Tungus-Manchu and northern Mongol tribes shared forest expanses of Manchuria and Trans-Baikal. The following text describes the events in the Turkic khaganates and kingdoms in the north of China, which influenced the historical development of the Mongol tribes. The period of the Qidan Liao dynasty (10th ‒ 12th century is of great importance because the core of the Mongol nomadic tribes was formed at that time in the northeastern Mongolia, that were gradually spreading over the steps to the west. During the Jurchen Jin dynasty (12th ‒ 13th century the importance of the Mongol tribes in the steppe increased. The attempts of political unification of the Mongols appeared during that period – for the first time in the mid-12th century, during the reign of Khabul Khan. The final part of the paper describes the struggle of Temujin (Temüjin, the future Genghis Khan, for the unification of the Mongol-Turkic tribes. After victory over

  17. DISSECTING THE RED SEQUENCE. II. STAR FORMATION HISTORIES OF EARLY-TYPE GALAXIES THROUGHOUT THE FUNDAMENTAL PLANE

    International Nuclear Information System (INIS)

    Graves, Genevieve J.; Faber, S. M.; Schiavon, Ricardo P.

    2009-01-01

    This analysis uses spectra of ∼16,000 nearby Sloan Digital Sky Survey quiescent galaxies to track variations in galaxy star formation histories (SFHs) along and perpendicular to the fundamental plane (FP). We sort galaxies by their FP properties (σ, R e , and I e ) and construct high signal-to-noise ratio mean galaxy spectra that span the breadth and thickness of the FP. From these spectra, we determine mean luminosity-weighted ages, [Fe/H], [Mg/H], and [Mg/Fe] based on single stellar population models using the method described in Graves and Schiavon. In agreement with previous work, the SFHs of early-type galaxies are found to form a two-parameter family. The major trend is that mean age, [Fe/H], [Mg/H], and [Mg/Fe] all increase with σ. However, no stellar population property shows any dependence on R e at fixed σ, suggesting that σ and not dynamical mass (M dyn ∝ σ 2 R e ) is the better predictor of past SFH. In addition to the main trend with σ, galaxies also show a range of population properties at fixed σ that are strongly correlated with surface brightness residuals from the FP (Δlog I e ), such that higher surface brightness galaxies have younger mean ages, higher [Fe/H], higher [Mg/H], and lower [Mg/Fe] than lower surface brightness galaxies. These latter trends are a major new constraint on SFHs.

  18. Towards a Social History of Archaeology: The Case of the Excavators of Early Iron Age Burial Mounds in Southern Germany

    Directory of Open Access Journals (Sweden)

    Nils Müller-Scheessel

    2008-05-01

    Full Text Available While the general history of archaeology has received a growing interest lately1, these efforts still lack a common research-guiding agenda. Furthermore, most of the studies still concentrate on biographies and event history. The embedding of archaeology in the structures and conditions of its time is still a kind of terra incognita. The few well known publications (e. g. Hudson 1981; Kristiansen 1981; Patterson 1986; 1995 emphasize the gap only more. The lack of a significant amount of literature especially on the social history of archaeology is all the more surprising as the early interest in archaeology shows a clear social bias: archaeology was (and still is? a recreational activity for the educated and the well-off. While Hudson’s book in particular is very readable, it is clearly meant to provide only a very broad picture. Along with the other publications mentioned above it is now somewhat dated; the lack of recent works on this topic thus highlight the lack of interest in the social history of archaeology even more.2 However, this essay does not deal with this deplorable fact, but seeks to present some ‘hard’ data on only one, albeit important activity of early archaeological excavations, particularly those of burial mounds. Its focus is on Southern Germany and on graves from the early Iron Age.3

  19. Who says this is a modern disorder? The early history of attention deficit hyperactivity disorder

    Science.gov (United States)

    Martinez-Badía, Jose; Martinez-Raga, Jose

    2015-01-01

    Attention-deficit hyperactivity disorder (ADHD) is a complex, heterogeneous and multifactorial neurodevelopmental disorder characterized by persistent symptoms of inattention, hyperactivity and impulsivity. Although the first clinical description of a constellation of symptoms highly resembling to what currently could be diagnosed as ADHD is generally attributed to George F Still in 1902, there are scattered but significant published historical medical, scientific and non-scientific reports, much prior to Still’s lectures, of what is currently conceptualized as ADHD. The present report aimed at exploring the early history of ADHD, prior to the 20th century in the medical literature and in other historical sources, to provide clinicians, researchers and other professionals with a better understanding of the roots and current conceptualization of this disorder. It is possible to find clues and highly suggestive descriptions of individuals presenting symptoms resembling what is currently defined as ADHD in the literature, in paintings or in the Bible. However, the earliest medical reports of individuals with abnormal degrees of inattention, distractibility and overactivity date from the last quarter of the 18th century, included in two of the first textbooks specifically on the subject of mental diseases, published by the German Melchior Adam Weikard and the Scottish Sir Alexander Crichton. During the 19th century some eminent physicians from Germany, France or Great Britain, such as Charles West, Thomas C Albutt, Thomas S Clouston, William W, Ireland, John Haslam, Heinrich Neumann, or Désiré-Magloire Bourneville, among others provided clinical depictions of patients that most likely presently would be diagnosed as having ADHD. Whilst some of the children described by Still and his predecessors may have suffered from a variety of neurological and psychiatric disorders, many of these patients showed clear symptoms of ADHD and may present with comorbid disorders, as

  20. RECONSTRUCTING THE SOLAR WIND FROM ITS EARLY HISTORY TO CURRENT EPOCH

    Energy Technology Data Exchange (ETDEWEB)

    Airapetian, Vladimir S.; Usmanov, Arcadi V., E-mail: vladimir.airapetian@nasa.gov, E-mail: avusmanov@gmail.com [NASA Goddard Space Flight Center, Greenbelt, MD (United States)

    2016-02-01

    Stellar winds from active solar-type stars can play a crucial role in removal of stellar angular momentum and erosion of planetary atmospheres. However, major wind properties except for mass-loss rates cannot be directly derived from observations. We employed a three-dimensional magnetohydrodynamic Alfvén wave driven solar wind model, ALF3D, to reconstruct the solar wind parameters including the mass-loss rate, terminal velocity, and wind temperature at 0.7, 2, and 4.65 Gyr. Our model treats the wind thermal electrons, protons, and pickup protons as separate fluids and incorporates turbulence transport, eddy viscosity, turbulent resistivity, and turbulent heating to properly describe proton and electron temperatures of the solar wind. To study the evolution of the solar wind, we specified three input model parameters, the plasma density, Alfvén wave amplitude, and the strength of the dipole magnetic field at the wind base for each of three solar wind evolution models that are consistent with observational constrains. Our model results show that the velocity of the paleo solar wind was twice as fast, ∼50 times denser and 2 times hotter at 1 AU in the Sun's early history at 0.7 Gyr. The theoretical calculations of mass-loss rate appear to be in agreement with the empirically derived values for stars of various ages. These results can provide realistic constraints for wind dynamic pressures on magnetospheres of (exo)planets around the young Sun and other active stars, which is crucial in realistic assessment of the Joule heating of their ionospheres and corresponding effects of atmospheric erosion.

  1. The early history of glaucoma: the glaucous eye (800 BC to 1050 AD

    Directory of Open Access Journals (Sweden)

    Leffler CT

    2015-02-01

    Full Text Available Christopher T Leffler,1 Stephen G Schwartz,2 Tamer M Hadi,3 Ali Salman,1 Vivek Vasuki1 1Department of Ophthalmology, Virginia Commonwealth University, Richmond, VA, USA; 2Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL, USA; 3Graduate School of Medicine, University of Tennessee Medical Center at Knoxville, TN, USA Abstract: To the ancient Greeks, glaukos occasionally described diseased eyes, but more typically described healthy irides, which were glaucous (light blue, gray, or green. During the Hippocratic period, a pathologic glaukos pupil indicated a media opacity that was not dark. Although not emphasized by present-day ophthalmologists, the pupil in acute angle closure may appear somewhat green, as the mid-dilated pupil exposes the cataractous lens. The ancient Greeks would probably have described a (normal green iris or (diseased green pupil as glaukos. During the early Common Era, eye pain, a glaucous hue, pupil irregularities, and absence of light perception indicated a poor prognosis with couching. Galen associated the glaucous hue with a large, anterior, or hard crystalline lens. Medieval Arabic authors translated glaukos as zarqaa, which also commonly described light irides. Ibn Sina (otherwise known as Avicenna wrote that the zarqaa hue could occur due to anterior prominence of the lens and could occur in an acquired manner. The disease defined by the glaucous pupil in antiquity is ultimately indeterminate, as the complete syndrome of acute angle closure was not described. Nonetheless, it is intriguing that the glaucous pupil connoted a poor prognosis, and came to be associated with a large, anterior, or hard crystalline lens. Keywords: glaucoma, history of ophthalmology, couching

  2. RECONSTRUCTING THE SOLAR WIND FROM ITS EARLY HISTORY TO CURRENT EPOCH

    International Nuclear Information System (INIS)

    Airapetian, Vladimir S.; Usmanov, Arcadi V.

    2016-01-01

    Stellar winds from active solar-type stars can play a crucial role in removal of stellar angular momentum and erosion of planetary atmospheres. However, major wind properties except for mass-loss rates cannot be directly derived from observations. We employed a three-dimensional magnetohydrodynamic Alfvén wave driven solar wind model, ALF3D, to reconstruct the solar wind parameters including the mass-loss rate, terminal velocity, and wind temperature at 0.7, 2, and 4.65 Gyr. Our model treats the wind thermal electrons, protons, and pickup protons as separate fluids and incorporates turbulence transport, eddy viscosity, turbulent resistivity, and turbulent heating to properly describe proton and electron temperatures of the solar wind. To study the evolution of the solar wind, we specified three input model parameters, the plasma density, Alfvén wave amplitude, and the strength of the dipole magnetic field at the wind base for each of three solar wind evolution models that are consistent with observational constrains. Our model results show that the velocity of the paleo solar wind was twice as fast, ∼50 times denser and 2 times hotter at 1 AU in the Sun's early history at 0.7 Gyr. The theoretical calculations of mass-loss rate appear to be in agreement with the empirically derived values for stars of various ages. These results can provide realistic constraints for wind dynamic pressures on magnetospheres of (exo)planets around the young Sun and other active stars, which is crucial in realistic assessment of the Joule heating of their ionospheres and corresponding effects of atmospheric erosion

  3. The complex early life history of a marine estuarine-opportunist fish species, Solea turbynei (Soleidae from temperate South Africa

    Directory of Open Access Journals (Sweden)

    Nadine A. Strydom

    2015-06-01

    Full Text Available The early life history stages and ecology of Solea turbynei, a marine estuarine-opportunist species, is described from nursery areas in Algoa Bay, South Africa. Early life history stages were collected over multiple years from known nursery habitats using plankton, fyke and larval seine nets. The larvae are described using morphometric measurements, meristic counts and pigmentation based on 29 individuals. Solea turbynei is differentiated from other Soleidae by the small size at flexion (3-4 mm, low myomere count and presence of two characteristic blotches of pigment on the dorsal fin. This species has a unique early life history strategy in that the larvae progressively span nearshore, surf zone and estuarine habitats with ontogeny. Abundance of preflexion stages peaks in summer in nearshore waters, indicative of peak spawning period but preflexion larvae are present throughout the year, indicating protracted spawning by adults. At flexion stage, larvae utilize surf zones where metamorphosis and settlement takes place. Early juveniles migrate into the sandy lower reaches of estuaries, after which fish take up residency to adulthood. Warm water is important for larval growth and survival in the nearshore, while turbidity shows a positive relationship with recruitment into estuarine nurseries.

  4. Cumulative Effects of Nutrient Enrichment and Elevated Temperature Compromise the Early Life History Stages of the Coral Acropora tenuis.

    Science.gov (United States)

    Humanes, Adriana; Noonan, Sam H C; Willis, Bette L; Fabricius, Katharina E; Negri, Andrew P

    2016-01-01

    Inshore coral reefs are experiencing the combined pressures of excess nutrient availability associated with coastal activities and warming seawater temperatures. Both pressures are known to have detrimental effects on the early life history stages of hard corals, but studies of their combined effects on early demographic stages are lacking. We conducted a series of experiments to test the combined effects of nutrient enrichment (three levels) and elevated seawater temperature (up to five levels) on early life history stages of the inshore coral Acropora tenuis, a common species in the Indo-Pacific and Red Sea. Gamete fertilization, larval survivorship and larval settlement were all significantly reduced as temperature increased, but only fertilization was further affected by simultaneous nutrient enrichment. Combined high temperatures and nutrient enrichment affected fertilization in an additive manner, whereas embryo abnormalities increased synergistically. Higher than normal temperatures (32°C) increased coral juvenile growth rates 1.6-fold, but mortality also increased by 50%. The co-occurrence of nutrient enrichment with high temperatures reduced juvenile mortality to 36%, ameliorating temperature stress (antagonistic interaction). Overall, the types of effect (additive vs synergistic or antagonistic) and their magnitude varied among life stages. Gamete and embryo stages were more affected by temperature stress and, in some cases, also by nutrient enrichment than juveniles. The data suggest that coastal runoff events might exacerbate the impacts of warming temperatures on fertilization if these events co-occur during corals spawning. The cumulative impacts of simultaneous exposure to nutrient enrichment and elevated temperatures over all early life history stages increases the likelihood for failure of larval supply and recruitment for this coral species. Our results suggest that improving the water quality of river discharges into coastal areas might help to

  5. Cumulative Effects of Nutrient Enrichment and Elevated Temperature Compromise the Early Life History Stages of the Coral Acropora tenuis

    Science.gov (United States)

    Noonan, Sam H. C.; Willis, Bette L.; Fabricius, Katharina E.; Negri, Andrew P.

    2016-01-01

    Inshore coral reefs are experiencing the combined pressures of excess nutrient availability associated with coastal activities and warming seawater temperatures. Both pressures are known to have detrimental effects on the early life history stages of hard corals, but studies of their combined effects on early demographic stages are lacking. We conducted a series of experiments to test the combined effects of nutrient enrichment (three levels) and elevated seawater temperature (up to five levels) on early life history stages of the inshore coral Acropora tenuis, a common species in the Indo-Pacific and Red Sea. Gamete fertilization, larval survivorship and larval settlement were all significantly reduced as temperature increased, but only fertilization was further affected by simultaneous nutrient enrichment. Combined high temperatures and nutrient enrichment affected fertilization in an additive manner, whereas embryo abnormalities increased synergistically. Higher than normal temperatures (32°C) increased coral juvenile growth rates 1.6-fold, but mortality also increased by 50%. The co-occurrence of nutrient enrichment with high temperatures reduced juvenile mortality to 36%, ameliorating temperature stress (antagonistic interaction). Overall, the types of effect (additive vs synergistic or antagonistic) and their magnitude varied among life stages. Gamete and embryo stages were more affected by temperature stress and, in some cases, also by nutrient enrichment than juveniles. The data suggest that coastal runoff events might exacerbate the impacts of warming temperatures on fertilization if these events co-occur during corals spawning. The cumulative impacts of simultaneous exposure to nutrient enrichment and elevated temperatures over all early life history stages increases the likelihood for failure of larval supply and recruitment for this coral species. Our results suggest that improving the water quality of river discharges into coastal areas might help to

  6. Preventing Early Child Maltreatment: Implications from a Longitudinal Study of Maternal Abuse History, Substance Use Problems, and Offspring Victimization

    Science.gov (United States)

    Appleyard, Karen; Berlin, Lisa J.; Rosanbalm, Katherine D.; Dodge, Kenneth A.

    2013-01-01

    In the interest of improving child maltreatment prevention science, this longitudinal, community based study of 499 mothers and their infants tested the hypothesis that mothers’ childhood history of maltreatment would predict maternal substance use problems, which in turn would predict offspring victimization. Mothers (35% White/non-Latina, 34% Black/non-Latina, 23% Latina, 7% other) were recruited and interviewed during pregnancy, and child protective services records were reviewed for the presence of the participants’ target infants between birth and age 26 months. Mediating pathways were examined through structural equation modeling and tested using the products of the coefficients approach. The mediated pathway from maternal history of sexual abuse to substance use problems to offspring victimization was significant (standardized mediated path [ab]=.07, 95% CI [.02, .14]; effect size=.26), as was the mediated pathway from maternal history of physical abuse to substance use problems to offspring victimization (standardized mediated path [ab]=.05, 95% CI [.01, .11]; effect size =.19). There was no significant mediated pathway from maternal history of neglect. Findings are discussed in terms of specific implications for child maltreatment prevention, including the importance of assessment and early intervention for maternal history of maltreatment and substance use problems, targeting women with maltreatment histories for substance use services, and integrating child welfare and parenting programs with substance use treatment. PMID:21240556

  7. History and development of Carboniferous palynology in North America during the early and middle twentieth century

    Energy Technology Data Exchange (ETDEWEB)

    Cross, A.T.; Kosanke, R.M. [Michigan State University, East Lansing, MI (United States). Dept. of Geological Sciences

    1995-12-31

    Three main roots of upper Palaeozoic palynology in North America date from the opening of the twentieth century. These are Gresley`s recognition of spores in Iowa coal balls in 1901, analyses of spores by Sellards from Mazon Creek compressions in 1902, and Thiessen`s analyses of dispersed spores from coal maceration and thin sections in 1913. The Pollen Analysis Circular brought workers into contact in the 1940s and generated interest in older fossils. The Paleobotanical Section of the Botanical Society of America (1936) and the Coal Geology Division of the Geological Society of America (1955) encouraged palynologists to participate in meetings and field trips. Fundamental papers by Schopf et al. in 1944 and Kosanke in 1950 established Carboniferous palynology in North America. Active teaching and research centers at the University of Chicago in the 1920s and the University of Illinois and Coe College in the 1930s spawned new palynological centers, particularly throughout the Midwest. Palynological contributions on dispersed spores, mainly from coals and associated rocks, appeared from educational centers from 1929 through the 1950s. Limited reviews of early researches at early palynologic centers are here included by region. Palynology applied to petroleum exploration appeared in the 1940s and major petroleum companies had palynology laboratories in place by 1960. The first international palynology journals appeared in the 1950s and catalogs first appeared in the mid-1960s, except the Catalog of Fossil Spores and Pollen, which began in 1957. The first specific palynology organization, the American Association of Stratigraphic Palynologisst, was founded in 1968. 304 refs., 38 figs

  8. Unity and Diversity as a Theme in Early Modern Dutch Religious History: an Interpretation

    NARCIS (Netherlands)

    Spaans, J.W.

    1996-01-01

    The Reformation in the Low Countries fascinates both church historians and general historians. Religious change and political revolution went hand in hand. The history of the Reformation is an integral part of the history of the birth of the Dutch nation. Although well-researched, its attraction is

  9. The discovery of radium 100 years ago and the impact on the early history of nuclear science

    Energy Technology Data Exchange (ETDEWEB)

    Adloff, J.P. [University Louis Pasteur, 63 Rue Saint Urbain 67100 Strasbourg (France)

    1999-09-01

    One hundred years ago, Pierre and Marie Curie reawakened the topic of uranic rays and discovered two radioelements, polonium in July 1898 and radium in December. The circumstances of these events which announced the beginning of radiochemistry are reviewed at the light of the laboratory notebooks and the publications of the authors. The role of radium in the early history of radioactivity and nuclear sciences is emphasized. (author)

  10. The discovery of radium 100 years ago and the impact on the early history of nuclear science

    International Nuclear Information System (INIS)

    Adloff, J.P.

    1999-01-01

    One hundred years ago, Pierre and Marie Curie reawakened the topic of uranic rays and discovered two radioelements, polonium in July 1898 and radium in December. The circumstances of these events which announced the beginning of radiochemistry are reviewed at the light of the laboratory notebooks and the publications of the authors. The role of radium in the early history of radioactivity and nuclear sciences is emphasized. (author)

  11. Associations of personal and family preeclampsia history with the risk of early-, intermediate- and late-onset preeclampsia.

    Science.gov (United States)

    Boyd, Heather A; Tahir, Hassaan; Wohlfahrt, Jan; Melbye, Mads

    2013-12-01

    Preeclampsia encompasses multiple conditions of varying severity. We examined the recurrence and familial aggregation of preeclampsia by timing of onset, which is a marker for severity. We ascertained personal and family histories of preeclampsia for women who delivered live singletons in Denmark in 1978-2008 (almost 1.4 million pregnancies). Using log-linear binomial regression, we estimated risk ratios for the associations between personal and family histories of preeclampsia and the risk of early-onset (before 34 weeks of gestation, which is typically the most severe), intermediate-onset (at 34-36 weeks of gestation), and late-onset (after 36 weeks of gestation) preeclampsia. Previous early-, intermediate-, or late-onset preeclampsia increased the risk of recurrent preeclampsia with the same timing of onset 25.2 times (95% confidence interval (CI): 21.8, 29.1), 19.7 times (95% CI: 17.0, 22.8), and 10.3 times (95% CI: 9.85, 10.9), respectively, compared with having no such history. Preeclampsia in a woman's family was associated with a 24%-163% increase in preeclampsia risk, with the strongest associations for early- and intermediate-onset preeclampsia in female relatives. Preeclampsia in the man's family did not affect a woman's risk of early-onset preeclampsia and was only weakly associated with her risks of intermediate- and late-onset preeclampsia. Early-onset preeclampsia appears to have the largest genetic component, whereas environmental factors likely contribute most to late-onset preeclampsia. The role of paternal genes in the etiology of preeclampsia appears to be limited.

  12. Early life history pelagic exposure profiles of selected commercially important fish species in the Gulf of Alaska

    Science.gov (United States)

    Doyle, Miriam J.; Mier, Kathryn L.

    2016-10-01

    A synthesis of nearly four decades of ichthyoplankton survey data from the Gulf of Alaska was undertaken to provide the most comprehensive information available on the early life history ecology of five focal species: Pacific Cod (Gadus macrocephalus), Walleye Pollock (Gadus chalcogrammus), Pacific Ocean Perch (Sebastes alutus), Sablefish (Anoplopoma fimbria), and Arrowtooth Flounder (Atheresthes stomias). This analysis of historical data, along with information from published studies, is presented here in the form of ecological reviews of the species during their planktonic phase. The reviews include descriptions of temporal and spatial patterns of exposure to the environment, and interpretation regarding associated sensitivities to environmental forcing. On a temporal scale, patterns in abundance of eggs and larvae are synthesized that characterize seasonal exposure to the pelagic environment, and interannual variation that is presumed to incorporate responses to long-term environmental forcing. Spatial patterns are synthesized to identify horizontal and vertical extent of egg and larval distributions, delineate areas of primary larval habitat, and illuminate egg and larval drift pathways. The observed patterns are discussed with respect to characterizing species early life history strategies, identifying long-term adaptations to the Gulf of Alaska environment, and associated resilience and vulnerability factors that may modulate early life responses to environmental forcing in this region. For each species, gaps in knowledge are identified and are concerned primarily with the period of transition between the larval and juvenile stage, and feeding habits and ecology across seasons, habitats and sub-intervals of early ontogeny. These early life history reviews advance our ecological understanding of the pelagic phase, and fine-tune our focus for the investigation of potential response mechanisms to environmental forcing at appropriate, species-specific temporal

  13. Factors regulating early life history dispersal of Atlantic cod (Gadus morhua) from coastal Newfoundland.

    Science.gov (United States)

    Stanley, Ryan R E; deYoung, Brad; Snelgrove, Paul V R; Gregory, Robert S

    2013-01-01

    To understand coastal dispersal dynamics of Atlantic cod (Gadus morhua), we examined spatiotemporal egg and larval abundance patterns in coastal Newfoundland. In recent decades, Smith Sound, Trinity Bay has supported the largest known overwintering spawning aggregation of Atlantic cod in the region. We estimated spawning and dispersal characteristics for the Smith Sound-Trinity Bay system by fitting ichthyoplankton abundance data to environmentally-driven, simplified box models. Results show protracted spawning, with sharply increased egg production in early July, and limited dispersal from the Sound. The model for the entire spawning season indicates egg export from Smith Sound is 13%•day(-1) with a net mortality of 27%•day(-1). Eggs and larvae are consistently found in western Trinity Bay with little advection from the system. These patterns mirror particle tracking models that suggest residence times of 10-20 days, and circulation models indicating local gyres in Trinity Bay that act in concert with upwelling dynamics to retain eggs and larvae. Our results are among the first quantitative dispersal estimates from Smith Sound, linking this spawning stock to the adjacent coastal waters. These results illustrate the biophysical interplay regulating dispersal and connectivity originating from inshore spawning of coastal northwest Atlantic.

  14. Factors regulating early life history dispersal of Atlantic cod (Gadus morhua from coastal Newfoundland.

    Directory of Open Access Journals (Sweden)

    Ryan R E Stanley

    Full Text Available To understand coastal dispersal dynamics of Atlantic cod (Gadus morhua, we examined spatiotemporal egg and larval abundance patterns in coastal Newfoundland. In recent decades, Smith Sound, Trinity Bay has supported the largest known overwintering spawning aggregation of Atlantic cod in the region. We estimated spawning and dispersal characteristics for the Smith Sound-Trinity Bay system by fitting ichthyoplankton abundance data to environmentally-driven, simplified box models. Results show protracted spawning, with sharply increased egg production in early July, and limited dispersal from the Sound. The model for the entire spawning season indicates egg export from Smith Sound is 13%•day(-1 with a net mortality of 27%•day(-1. Eggs and larvae are consistently found in western Trinity Bay with little advection from the system. These patterns mirror particle tracking models that suggest residence times of 10-20 days, and circulation models indicating local gyres in Trinity Bay that act in concert with upwelling dynamics to retain eggs and larvae. Our results are among the first quantitative dispersal estimates from Smith Sound, linking this spawning stock to the adjacent coastal waters. These results illustrate the biophysical interplay regulating dispersal and connectivity originating from inshore spawning of coastal northwest Atlantic.

  15. A New Model of the Early Paleozoic Tectonics and Evolutionary History in the Northern Qinling, China

    Science.gov (United States)

    Dong, Yunpeng; Zhang, Guowei; Yang, Zhao; Qu, Hongjun; Liu, Xiaoming

    2010-05-01

    The Qinling Orogenic Belt extends from the Qinling Mountains in the west to the Dabie Mountains in the east. It lies between the North China and South China Blocks, and is bounded on the north by the Lushan fault and on the south by the Mianlue-Bashan-Xiangguang fault (Zhang et al., 2000). The Qinling Orogenic Belt itself is divided into the North and South Qinling Terranes by the Shangdan suture zone. Although the Shangdan zone is thought to represent the major suture separating the two blocks, there still exists debate about the timing and mechanism of convergence between these two blocks. For instance, some authors suggested an Early Paleozoic collision between the North China Block and South China Block (Ren et al., 1991; Kroner et al., 1993; Zhai et al., 1998). Others postulated left-lateral strike-slip faulting along the Shangdan suture at ca. 315 Ma and inferred a pre-Devonian collision between the two blocks (Mattauer et al., 1985; Xu et al., 1988). Geochemistry of fine-grained sediments in the Qinling Mountains was used to argue for a Silurian-Devonian collision (Gao et al., 1995). A Late Triassic collision has also been proposed (Sengor, 1985; Hsu et al., 1987; Wang et al., 1989), based on the formation of ultrahigh-pressure metamorphic rocks in the easternmost part of the Qinling Orogenic Belt at ~230 Ma (e.g., Li et al., 1993; Ames et al., 1996). Paleomagnetic data favor a Late Triassic-Middle Jurassic amalgamation of the North China and South China Blocks (Zhao and Coe, 1987; Enkin et al., 1992). It is clear that most authors thought that the Qinling Mountains are a collisional orogen, even they have different methods about the timing of the orogeny. Based on new detailed investigations, we propose a new model of the Early Paleozoic Tectonics and Evolutionary History between the North China and South China Blocks along the Shangdan Suture. The Shangdan suture is marked by a great number of ophiolites, island-arc volcanic rocks and other related rock

  16. The natural history of early versus late disability accumulation in primary progressive MS.

    Science.gov (United States)

    Koch, Marcus W; Greenfield, Jamie; Javizian, Omid; Deighton, Stephanie; Wall, Winona; Metz, Luanne M

    2015-06-01

    Primary progressive multiple sclerosis (PPMS) is the least common MS disease course and carries the worst prognosis. In relapsing-remitting multiple sclerosis (RRMS) disability accumulation occurs in two distinct phases, but it is unclear whether this is also true for PPMS. Here we investigate factors associated with early and late disability accumulation in PPMS. We used Kaplan-Meier survival analyses and Cox regression to investigate the influence of sex, age at disease onset and onset symptoms on time to, and age at, Expanded Disability Status Scale (EDSS) 4 and 6, as well as the time from EDSS 4 to 6 in patients with PPMS. We identified 500 patients with PPMS. The analyses on time to EDSS 4 included 358 patients, and those on time to EDSS 6 included 392 patients. The median times to EDSS 4 and EDSS 6 were 5 and 9 years. The analyses on age at EDSS 4 included 360 patients, and those on age at EDSS 6 included 402 patients. The median ages at EDSS 4 and EDSS 6 were 51 and 55 years. Older age at onset and bilateral motor onset symptoms were independently associated with a shorter time to both EDSS 4 and EDSS 6. Sex and other onset symptoms were not associated with time to, or age at, landmark disability. Only age at onset was significantly associated with the time from EDSS 4 to EDSS 6. Age at disease onset is the most important predictor of disability accumulation in PPMS. Bilateral motor onset symptoms were associated with quicker disease progression. In contrast to RRMS, we found no evidence for distinct phases of disability accumulation in PPMS. Disability accumulation in PPMS appears to be affected by the same factors throughout its course. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  17. [Anatomia practica: features from the history of early patho-anatomy].

    Science.gov (United States)

    Jensen, Olaf Myhre

    2002-01-01

    Since the anatomy school of Alexandria during the fourth og third century before Christ dissection of the human body seems not to have been practiced until late Medieval or early Renaissance period, undoubtedly due to ethical and religious aversions. The teaching of anatomy was based on Galen using animal dissection. In the fourteenth and fifteenth centuries, however, anatomical examinations of the human body slowly began, seemingly for the purpose of describing both the normal structure and the abnormal structure caused by diseases, maldevelopment or trauma. This latter branch of anatomy was called practical, medical or correlative anatomy and corresponds to what we today name as patho-anatomy. Antonio Benivieni of Florence (1442-1502) is the first one to collect (and publish) a series of clinical observations some of which could be correlated to post mortem findings. It is unknown, however, whether the autopsies were performed by himself; and there is no mentioning of technique or circumstances for sectioning. Studies of the dead body by incision for the purpose of displaying diseased organs (autopsy) seem to have been an accepted practice for which relatives consented in those days. Other medical doctors in the years to follow, as for instance Fernel (1485-1558) in Paris, Eustachius (1524-1574) in Rome, Felix Plater (1536-1614) in Basle and Th. Bartholin (1616-1680) in Copenhagen have used the anatomical method for the study of diseases. Further, Schenck (1530-1598) in Freiburg and Bonet (1620-1689) in Genéva collected and published large series of clinical symptoms which had been related to post mortem findings dating back to ancient observers. This is the scientific background for anatomists as Morgagni, Lieutaud, Baillie, Bichât and others who founded the morbid anatomy on which the study of disease flourished in the classical patho-anatomical era of the nineteenth century with names as Rokitanski and Virchow.

  18. Influencing factors for early acute cerebrovascular accidents in patients with stroke history following off-pump coronary artery bypass grafting.

    Science.gov (United States)

    Wang, Bin; Jia, Ming; Jia, Shijie; Wan, Jiuhe; Zhou, Xiao; Luo, Zhimin; Zhou, Ye; Zhang, Jianqun

    2014-06-01

    To analyse risk factors for early acute cerebrovascular accidents following off-pump coronary artery bypass grafting (OPCAB) in patients with stroke history, and to propose preventive measures to reduce the incidence of these events. A total of 468 patients with a history of stroke underwent OPCAB surgery in Beijing Anzhen Hospital of China from January 2010 to September 2012. They were retrospectively divided into two groups according to the occurrence of early acute cerebrovascular accidents within 48 hours following OPCAB. Multivariate logistic regression analysis was used to find risk or protective factors for early acute cerebrovascular accidents following the OPCAB. Fifty-two patients (11.1%) suffered from early acute cerebrovascular accidents in 468 patients, including 39 cases of cerebral infarction, two cases of cerebral haemorrhage, 11 cases of transient ischaemic attack (TIA). There were significant differences between the two groups in preoperative left ventricular ejection fraction ≤ 35%, severe bilateral carotid artery stenosis, poorly controlled hypertension, intraoperative application of Enclose® II proximal anastomotic device, postoperative acute myocardial infarction, atrial fibrillation, hypotension, ventilation time > 48h, ICU duration >48h and mortality. Multivariate logistic regression analysis showed that preoperative severe bilateral carotid stenosis (OR=6.378, 95%CI: 2.278-20.987) and preoperative left ventricular ejection fraction ≤ 35% (OR=2.737, 95%CI: 1.267-6.389), postoperative acute myocardial infarction (OR=3.644, 95%CI: 1.928-6.876), postoperative atrial fibrillation (OR=3.104, 95%CI:1.135∼8.016) and postoperative hypotension (OR=4.173, 95%CI: 1.836∼9.701) were independent risk factors for early acute cerebrovascular accidents in patients with a history of stroke following OPCAB procedures, while intraoperative application of Enclose® II proximal anastomotic device was protective factor (OR=0.556, 95%CI: 0.337-0.925). This

  19. Life history plasticity of a tropical seabird in response to El Niño anomalies during early life.

    Directory of Open Access Journals (Sweden)

    Sergio Ancona

    Full Text Available Food shortage and other challenges associated with El Niño Southern Oscillation (ENSO experienced early in life may have long-term impacts on life history traits, but these potential impacts remain virtually unexplored. By monitoring 2556 blue-footed boobies from 11 cohorts, we showed that birds facing warm water ENSO conditions (and probably low food availability in the natal year were underweight at fledging, recruited earlier and bred less frequently, but showed no deficit in longevity or breeding success over the first 10 years. Life history impacts of ENSO were substantial when experienced in the prenatal year, the natal year, or the second year of life, and absent when experienced in the third year of life, implying that harsh conditions have greater effects when experienced earlier in life. Sexual differences in impacts depended on the age when warm water conditions were experienced: pre-natal and natal experience, respectively, induced early recruitment and influenced the relationship between age and laying date only in females, whereas second year experience reduced total breeding success only of males. Most surprising were positive transgenerational impacts in females: daughters of females that experienced ENSO conditions in their natal year showed improved breeding success. Developmental plasticity of boobies thus enables them to largely neutralize potential long-term impacts of harsh climatic conditions experienced early in life.

  20. Life history plasticity of a tropical seabird in response to El Niño anomalies during early life.

    Science.gov (United States)

    Ancona, Sergio; Drummond, Hugh

    2013-01-01

    Food shortage and other challenges associated with El Niño Southern Oscillation (ENSO) experienced early in life may have long-term impacts on life history traits, but these potential impacts remain virtually unexplored. By monitoring 2556 blue-footed boobies from 11 cohorts, we showed that birds facing warm water ENSO conditions (and probably low food availability) in the natal year were underweight at fledging, recruited earlier and bred less frequently, but showed no deficit in longevity or breeding success over the first 10 years. Life history impacts of ENSO were substantial when experienced in the prenatal year, the natal year, or the second year of life, and absent when experienced in the third year of life, implying that harsh conditions have greater effects when experienced earlier in life. Sexual differences in impacts depended on the age when warm water conditions were experienced: pre-natal and natal experience, respectively, induced early recruitment and influenced the relationship between age and laying date only in females, whereas second year experience reduced total breeding success only of males. Most surprising were positive transgenerational impacts in females: daughters of females that experienced ENSO conditions in their natal year showed improved breeding success. Developmental plasticity of boobies thus enables them to largely neutralize potential long-term impacts of harsh climatic conditions experienced early in life.

  1. 2013 Early Life History Experiment Data - Snake River sockeye salmon captive propagation

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In the early 1990s, Redfish Lake sockeye salmon from the Sawtooth Basin in Idaho were on the brink of extinction, and they were listed as endangered under the US...

  2. Efficacy of Early Diagnosis and Treatment in Women with a Family History of Breast Cancer

    Directory of Open Access Journals (Sweden)

    Pål Møller

    1999-01-01

    Full Text Available BACKGROUND: Surveillance programmes for women at increased genetic risk of breast cancer are being established worldwide but little is known of their efficacy in early detection of cancers and hence reduction in mortality.

  3. 2012 Early Life History Experiment Data - Snake River sockeye salmon captive propagation

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In the early 1990s, Redfish Lake sockeye salmon from the Sawtooth Basin in Idaho were on the brink of extinction, and they were listed as endangered under the US...

  4. Early Musical Training in Bel Canto Vocal Technique: A Brief History and Philosophy.

    Science.gov (United States)

    Gerstein, Christine Wondolowski

    This paper offers a brief history and philosophy of the origins of bel canto vocal style and describes the pedagogical methods used to achieve bel canto ideals in singing. The document discusses the adoption and development of this technique and how it developed over long periods of preparation in the foregoing centuries before the Baroque era.…

  5. The Legacy of Early Insecurity Histories in Shaping Adolescent Adaptation to Interparental Conflict

    Science.gov (United States)

    Davies, Patrick T.; Sturge-Apple, Melissa L.; Bascoe, Sonnette M.; Cummings, E. Mark

    2014-01-01

    This study tested whether the mediational pathway involving interparental conflict, adolescent emotional insecurity, and their psychological problems was altered by their earlier childhood histories of insecurity. Participants included 230 families, with the first of the five measurement occasions occurring when children were in first grade…

  6. Building a Digital Bookwheel Together: Annotated Books Online and the History of Early Modern Reading Practices

    NARCIS (Netherlands)

    Visser, A.S.Q.|info:eu-repo/dai/nl/120007657; Calis, R. A.

    2014-01-01

    Over the past three decades, the history of reading has become an increasingly lively field of scholarship. Important case studies have documented the freedom that individual readers have enjoyed in handling their books. On a structural level, however, the scholarship has been hampered by limited

  7. Early-Life Characteristics, Psychiatric History, and Cognition Trajectories in Later Life

    Science.gov (United States)

    Brown, Maria Teresa

    2010-01-01

    Purpose of the Study: Although considerable attention has been paid to the relationship between later-life depression and cognitive function, the relationship between a history of psychiatric problems and cognitive function is not very well documented. Few studies of relationships between childhood health, childhood disadvantage, and cognitive…

  8. Early life history and spatiotemporal changes in distribution of the rediscovered Suwannee moccasinshell Medionidus walkeri (Bivalvia: Unionidae)

    Science.gov (United States)

    Johnson, Nathan A.; Mcleod, John; Holcomb, Jordan; Rowe, Matthew T.; Williams, James D.

    2016-01-01

    Accurate distribution data are critical to the development of conservation and management strategies for imperiled species, particularly for narrow endemics with life history traits that make them vulnerable to extinction. Medionidus walkeri is a rare freshwater mussel endemic to the Suwannee River Basin in southeastern North America. This species was rediscovered in 2012 after a 16-year hiatus between collections and is currently proposed for listing under the Endangered Species Act. Our study fills knowledge gaps regarding changes in distribution and early life history requirements of M. walkeri. Spatiotemporal changes in M. walkeri distribution were displayed using a conservation status assessment map incorporating metadata from 98 historical (1916–1999) and 401 recent (2000–2015) site surveys from museums and field notes representing records for 312 specimens. Recent surveys detected M. walkeri only in the middle Suwannee subbasin (n = 86, 22 locations) and lower Santa Fe subbasin (n = 2, 2 locations), and it appears the species may be extirpated from 67% of historically occupied 10-digit HUCs. In our laboratory experiments, M. walkeri successfully metamorphosed on Percina nigrofasciata (56.2% ± 8.9) and Etheostoma edwini (16.1% ± 7.9) but not on Trinectes maculatus, Lepomis marginatus, Notropis texanus, Noturus leptacanthus, Etheostoma fusiforme, or Gambusia holbrooki. We characterize M. walkeri as a lure-displaying host fish specialist and a long-term brooder (bradytictic), gravid from fall to early summer of the following year. The early life history and distribution data presented here provide the baseline framework for listing decisions and future efforts to conserve and recover the species.

  9. Beginnings and early history of the International Conferences on Magnetic Resonance in Biological Systems: development of the basic ideas in the field.

    Science.gov (United States)

    Jardetzky, Oleg

    2010-09-01

    The early history of the principal meeting in the field of biological NMR spectroscopy, the International Conference on Magnetic Resonance in Biological Systems (ICMRBS), is presented from the perspective of one of the founders. (c) 2010. Published by Elsevier Inc.

  10. The early history of research funding in South Africa: From the Research Grant Board to the FRD

    Directory of Open Access Journals (Sweden)

    Ndivhuwo M. Luruli

    2016-05-01

    Full Text Available The South African government has a long tradition of supporting research at public higher education institutions. Such support commenced in the early 20th century, although the exact nature of the support at that time is poorly documented. The oldest research funding model in the country was agency funding, which started as early as 1911 through the Royal Society of South Africa. A few years later, in 1918, a more coordinated funding body called the Research Grant Board (RGB was established in the Union of South Africa. The RGB offered competitive funding to individual academics in the natural and physical sciences. The human sciences were only supported much later with the establishment of the Council for Educational and Social Research in 1929. Here we review the history of research funding in South Africa, with a special focus on the work of the RGB between 1918 and 1938.

  11. How Should Clinicians Counsel a Woman with a Strong Family History of Early-Onset Alzheimer's Disease about Her Pregnancy?

    Science.gov (United States)

    Mapes, Marianna V; O'Brien, Barbara M; King, Louise P

    2017-07-01

    Counseling patients regarding the benefits, harms, and dilemmas of genetic testing is one of the greatest ethical challenges facing reproductive medicine today. With or without test results, clinicians grapple with how to communicate potential genetic risks as patients weigh their reproductive options. Here, we consider a case of a woman with a strong family history of early-onset Alzheimer's disease (EOAD). She is early in her pregnancy and unsure about learning her own genetic status. We address the ethical ramifications of each of her options, which include genetic testing, genetic counseling, and termination versus continuation of the pregnancy. Our analysis foregrounds clinicians' role in helping to ensure autonomous decision making as the patient reflects on these clinical options in light of her goals and values. © 2017 American Medical Association. All Rights Reserved.

  12. Prevalence of pathogenetic MC4R mutations in Italian children with early Onset obesity, tall stature and familial history of obesity

    Directory of Open Access Journals (Sweden)

    Crinò Antonino

    2009-03-01

    Full Text Available Abstract Background Melanocortin-4-receptor (MC4R mutations represent the most frequent genetic cause of non-syndromic early onset obesity. Children carrying MC4R mutations seem to show a particular phenotype characterized by early onset, severe obesity and high stature. To verify whether MC4R mutations are associated with this particular phenotype in the Italian pediatric population, we decided to screen the MC4R gene in a group of obese children selected on the basis of their phenotype. Methods To perform this study, a multicentric approach was designed. Particularly, to be enrolled in the study subjects needed to meet the following criteria: Body mass index ≥ 3 deviation scores according to age and sex, familiar history of obesity (at least one parent obese, obesity onset before the 10 years old, height ≥ 2 deviation scores. The coding region of MC4R gene was screened in 240 obese children (mean age 8.3 ± 3.1, mean BMI 30.8 ± 5.4 and in 200 controls (mean age 8.1 ± 2.8; mean BMI 14.2 ± 2.5. Results Three mutations have been found in five obese children. The S127L (C380T, found in three unrelated children, had been described and functionally characterized previously. The Q307X (C919T and the Y332H (T994C mutations were found in two patients. Functional studies showed that only Q307X impaired protein function. Conclusion The low prevalence of MC4R mutations (1.6% in this group of obese children selected according to the obesity degree, the tall stature and the family history of obesity was similar to the prevalence observed in previous screenings performed in obese adults and in not phenotypically selected obese children.

  13. Climate and history in the late 18th and early 19th centuries

    Science.gov (United States)

    Feldman, Theodore S.

    As in many areas of human knowledge, the notion of climate acquired a deeper historical content around the turn of the 19th century. Natural philosophers, geographers, and others became increasingly aware of climate's own history and its relation to human, plant and animal, and Earth history. This article examines several aspects of this “historicization” of climate.The lively 18th century discussion of the influence of climate on society is well known. Montesquieu is its most famous representative, but Voltaire, Hume, Kant, and others also participated. Their debate was literary more than scientific, their goal the understanding of man, not climate. Partly for this reason and partly because of the lack of good information on climates, they made no attempt to gather substantial climatic data. In fact, the importance of systematically collecting reliable data was scarcely understood in any area of natural philosophy before the last decades of the century [Cf. Frängsmyr et al., 1990; Feldman, 1990]. Instead, participants in the debate repeated commonplaces dating from Aristotle and Hippocrates and based their conclusions on unreliable reports from travelers. As Glacken wrote of Montesquieu, “his dishes are from old and well-tested recipes” [Glacken, 1967, chapter 12]. This is not to say that the debate over climatic influence was not significant—only that its significance lay more in the history of man than in the atmospheric sciences.

  14. Formalization and Interaction: Toward a Comprehensive History of Technology-Related Knowledge in Early Modern Europe.

    Science.gov (United States)

    Popplow, Marcus

    2015-12-01

    Recent critical approaches to what has conventionally been described as "scientific" and "technical" knowledge in early modern Europe have provided a wealth of new insights. So far, the various analytical concepts suggested by these studies have not yet been comprehensively discussed. The present essay argues that such comprehensive approaches might prove of special value for long-term and cross-cultural reflections on technology-related knowledge. As heuristic tools, the notions of "formalization" and "interaction" are proposed as part of alternative narratives to those highlighting the emergence of "science" as the most relevant development for technology-related knowledge in early modern Europe.

  15. The early history of high-temperature helium gas-cooled nuclear power reactors

    International Nuclear Information System (INIS)

    Simnad, M.T.; California Univ., San Diego, La Jolla, CA

    1991-01-01

    The original concepts in the proposals for high-temperature helium gas-cooled power reactors by Farrington Daniels, during the decade 1944-1955, are summarized. The early research on the development of the helium gas-cooled power reactors is reviewed, and the operational experiences with the first generation of HTGRs are discussed. (author)

  16. Teaching about the Influence of the Scientific Revolution and the Enlightenment on Early American History.

    Science.gov (United States)

    Mills, Randy K.; Woods, John C.

    1996-01-01

    Utilizes selections from 17th century philosophical writing as instructional material for a series of learning activities that reveal the influence of the material on early American democratic thought. Activities involve selections from Isaac Newton, John Locke, Montesquieu, Rousseau, The Declaration of Independence, and Bishop Bossuet. (MJP)

  17. Early Childhood Education Teachers: Life History, Life Course, and the Problem of Family-Work Balance

    Science.gov (United States)

    Bullough, Robert V., Jr.

    2016-01-01

    In contrast to the wider education literature, rather little is known about the lives of early childhood education (ECE) teachers and the impact of those lives on their practice. Drawing on surveys completed by Head Start assistant and lead teachers, teacher lifelines, and interviews, and through the lens of life-course theory, the author portrays…

  18. Early Activation of Cardiosurgical Patients: History and Terminology (a review of literature

    Directory of Open Access Journals (Sweden)

    I. A. Kozlov

    2010-01-01

    Full Text Available In foreign countries, the anesthesiological and resuscitative tactics that ensure the maximally rapid discontinuation of mechanical ventilation are regarded as a fundamental therapeutic component of the so-called fast-track cardiac surgery that provides a shorter length of hospital stay, an intensified therapeutic process, and lower-cost treatment. In the Russian literature, this methodic approach is customarily designated early activation, by bearing in mind that discontinuation of mechanical ventilation is a key point of postoperative recovery of the patients’ physical activity. The main Russian and foreign publications on the specific features of therapeutic tactics in early periods after cardiac surgery are historically analyzed. The paper covers the polemic between the supporters and opponents of the earliest activation of patients operated on under extracorporeal circulation, the change of views on a need for obligatory postoperative mechanical ventilation, and the impact of the rate of activation and physical activity on the quality of rehabilitation. Terminology and clinicians’ points of views on the optimum activation periods are analyzed. Key words: early activation, operations under extracorporeal circulation, tracheal extubation in an operating room, early tracheal extubation, postoperative rehabilitation of cardiosurgical patients.

  19. The star-formation histories of early-type galaxies from ATLAS3D

    NARCIS (Netherlands)

    McDermid, Richard M.; Alatalo, Katherine; Blitz, Leo; Bois, Maxime; Bournaud, Frédéric; Bureau, Martin; Cappellari, Michele; Crocker, Alison F.; Davies, Roger L.; Davis, Tim A.; de Zeeuw, P. T.; Duc, Pierre-Alain; Emsellem, Eric; Khochfar, Sadegh; Krajnović, Davor; Kuntschner, Harald; Lablanche, Pierre-Yves; Morganti, Rafaella; Naab, Thorsten; Oosterloo, Tom; Sarzi, Marc; Scott, Nic; Serra, Paolo; Weijmans, Anne-Marie; Young, Lisa M.

    We present an exploration of the integrated stellar populations of early-type galaxies (ETGs) from the ATLAS3D survey. We use two approaches: firstly the application of line-indices interpreted through single stellar population (SSP) models, which provide a single value of age, metallicity and

  20. Uncovering Hidden Dimensions of Australian Early Childhood Policy History: Insights from Interviews with Policy "Elites"

    Science.gov (United States)

    Logan, Helen; Sumsion, Jennifer; Press, Frances

    2014-01-01

    This article considers the value of elite interviews as a frequently overlooked methodology in investigations of policymaking in early childhood education and care (ECEC). We contextualise the discussion within a study that examines constructions of quality in Australian ECEC policymaking between 1972 and 2009. We conclude that, despite their…

  1. Prehistory and early history of the Malpai Borderlands: Archaeological synthesis and recommendations

    Science.gov (United States)

    Paul R. Fish; Suzanne K. Fish; John H. Madsen

    2006-01-01

    Prehispanic and early historic archaeological information for the Malpai Borderlands of southwest New Mexico and southeast Arizona is reviewed using data derived from field reconnaissance, discussion with relevant scholars, archival resources from varied agencies and institutions, and published literature. Previous regional research has focused on late prehistory (A.D...

  2. Tracing the 5000-year recorded history of inorganic thin films from ˜3000 BC to the early 1900s AD

    Science.gov (United States)

    Greene, J. E.

    2014-12-01

    Gold is very likely the first metal discovered by man, more than 11 000 years ago. However, unlike copper (˜9000 BC), bronze (˜3500 BC), and wrought iron (˜2500-3000 BC), gold is too soft for fabrication of tools and weapons. Instead, it was used for decoration, religious artifacts, and commerce. The earliest documented inorganic thin films were gold layers, some less than 3000 Å thick, produced chemi-mechanically by Egyptians approximately 5000 years ago. Examples, gilded on statues and artifacts (requiring interfacial adhesion layers), were found in early stone pyramids dating to ˜2650 BC in Saqqara, Egypt. Spectacular samples of embossed Au sheets date to at least 2600 BC. The Moche Indians of northern Peru developed electroless gold plating (an auto-catalytic reaction) in ˜100 BC and applied it to intricate Cu masks. The earliest published electroplating experiments were ˜1800 AD, immediately following the invention of the dc electrochemical battery by Volta. Chemical vapor deposition (CVD) of metal films was reported in 1649, atmospheric arc deposition of oxides (Priestley) in the mid-1760s, and atmospheric plasmas (Siemens) in 1857. Sols were produced in the mid-1850s (Faraday) and sol-gel films synthesized in 1885. Vapor phase film growth including sputter deposition (Grove, 1852), vacuum arc deposition ("deflagration," Faraday, 1857), plasma-enhanced CVD (Barthelot, 1869) and evaporation (Stefan, Hertz, and Knudsen, 1873-1915) all had to wait for the invention of vacuum pumps whose history ranges from ˜1650 for mechanical pumps, through ˜1865 for mercury pumps that produce ballistic pressures in small systems. The development of crystallography, beginning with Plato in 360 BC, Kepler in 1611, and leading to Miller indices (1839) for describing orientation and epitaxial relationships in modern thin film technology, was already well advanced by the 1780s (Haüy). The starting point for the development of heterogeneous thin film nucleation theory was

  3. 32 New Exoplanets Found

    Science.gov (United States)

    2009-10-01

    , which detects small changes in the radial velocity of a star as it wobbles slightly under the gentle gravitational pull from an (unseen) exoplanet, has been most prolific method in the search for exoplanets. In return for building the instrument, the HARPS consortium was granted 100 observing nights per year during a five-year period to carry out one of the most ambitious systematic searches for exoplanets so far implemented worldwide by repeatedly measuring the radial velocities of hundreds of stars that may harbour planetary systems. The programme soon proved very successful. Using HARPS, Mayor's team discovered - among others - in 2004, the first super-Earth (around µ Ara; in 2006, the trio of Neptunes around HD 69830; in 2007, Gliese 581d, the first super Earth in the habitable zone of a small star (eso0722); and in 2009, the lightest exoplanet so far detected around a normal star, Gliese 581e (eso0915). More recently, they found a potentially lava-covered world, with density similar to that of the Earth's (eso0933). "These observations have given astronomers a great insight into the diversity of planetary systems and help us understand how they can form," says team member Nuno Santos. The HARPS consortium was very careful in their selection of targets, with several sub-programmes aimed at looking for planets around solar-like stars, low-mass dwarf stars, or stars with a lower metal content than the Sun. The number of exoplanets known around low-mass stars - so-called M dwarfs - has also dramatically increased, including a handful of super Earths and a few giant planets challenging planetary formation theory. "By targeting M dwarfs and harnessing the precision of HARPS we have been able to search for exoplanets in the mass and temperature regime of super-Earths, some even close to or inside the habitable zone around the star," says co-author Xavier Bonfils. The team found three candidate exoplanets around stars that are metal-deficient. Such stars are thought to be

  4. Influences of spawning timing, water temperature, and climatic warming on early life history phenology in western Alaska sockeye salmon

    Science.gov (United States)

    Sparks, Morgan M.; Falke, Jeffrey A.; Quinn, Thomas P.; Adkison, Milo D.; Schindler, Daniel E.; Bartz, Krista K.; Young, Daniel B.; Westley, Peter A. H.

    2018-01-01

    We applied an empirical model to predict hatching and emergence timing for 25 western Alaska sockeye salmon (Oncorhynchus nerka) populations in four lake-nursery systems to explore current patterns and potential responses of early life history phenology to warming water temperatures. Given experienced temperature regimes during development, we predicted hatching to occur in as few as 58 d to as many as 260 d depending on spawning timing and temperature. For a focal lake spawning population, our climate-lake temperature model predicted a water temperature increase of 0.7 to 1.4 °C from 2015 to 2099 during the incubation period, which translated to a 16 d to 30 d earlier hatching timing. The most extreme scenarios of warming advanced development by approximately a week earlier than historical minima and thus climatic warming may lead to only modest shifts in phenology during the early life history stage of this population. The marked variation in the predicted timing of hatching and emergence among populations in close proximity on the landscape may serve to buffer this metapopulation from climate change.

  5. A Qualitative Application of the Belsky Model to Explore Early Care and Education Teachers' Mealtime History, Beliefs, and Interactions.

    Science.gov (United States)

    Swindle, Taren M; Patterson, Zachary; Boden, Carrie J

    Studies on factors associated with nutrition practices in early care and education settings often focus on sociodemographic and programmatic characteristics. This qualitative study adapted and applied Belsky's determinants of parenting model to inform a broader exploration of Early Care and Education Teachers (ECETs) practices. Qualitative cross-sectional study with ECETs. The researchers interviewed ECETs in their communities across a Southern state. Purposive sampling was employed to recruit ECETs (n = 28) from Head Start or state-funded centers serving low-income families. Developmental histories of ECETs regarding food and nutrition, beliefs about child nutrition, and teaching interactions related to food. Qualitative interviews were coded using a deductive content analysis approach. Three distinct interrelationships were observed across the themes. First, rules and routines regarding food and mealtime in the educators' childhood often aligned with educator beliefs and behaviors at meals in their classroom. Second, some ECETs described motivations to leave a healthy food legacy for children in their class. Finally, an experience of food insecurity appeared in narratives that also emphasized making sure children got enough through various strategies. The influence of ECET developmental histories and their related beliefs can be addressed through professional development and ongoing support. Future study should quantify model constructs in a larger sample and study their relationships over time. Copyright © 2017 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

  6. Reproductive ecology and early life history traits of the brooding coral, Porites astreoides, from shallow to mesophotic zones

    Science.gov (United States)

    Goodbody-Gringley, Gretchen; Wong, Kevin H.; Becker, Danielle M.; Glennon, Keegan; de Putron, Samantha J.

    2018-06-01

    Early life history traits of brooding corals are often affected by the environmental conditions experienced by parental colonies. Such parental effects can impact offspring survival, which influences the overall success of a population as well as resilience to environmental challenges. This study examines the reproductive ecology and early life history traits of the brooding coral Porites astreoides across a depth gradient in Bermuda. Fecundity, larval size, larval Symbiodinium density, and settlement success, as well as post-metamorphic juvenile survival, growth, and Symbiodinium density were compared across three reef sites representing an inshore patch reef (2-5 m), an offshore rim reef (8-10 m), and an upper-mesophotic reef (30-33 m). Although fecundity did not differ across sites, larvae produced by colonies on the patch reef site were smaller, had lower Symbiodinium densities, and had lower rates of settlement and juvenile survival compared to larvae from colonies on the rim and upper-mesophotic reef sites. Larvae produced by colonies from the rim and upper-mesophotic sites did not differ in size or Symbiodinium densities; however, rates of settlement, growth, and survival were higher for larvae from the upper-mesophotic site compared to those from the rim reef site. These results indicate that offspring quality and success vary among sites with differing environmental conditions and may imply higher recruitment potential and resilience for upper-mesophotic corals.

  7. Early history of European domestic cattle as revealed by ancient DNA.

    Science.gov (United States)

    Bollongino, R; Edwards, C J; Alt, K W; Burger, J; Bradley, D G

    2006-03-22

    We present an extensive ancient DNA analysis of mainly Neolithic cattle bones sampled from archaeological sites along the route of Neolithic expansion, from Turkey to North-Central Europe and Britain. We place this first reasonable population sample of Neolithic cattle mitochondrial DNA sequence diversity in context to illustrate the continuity of haplotype variation patterns from the first European domestic cattle to the present. Interestingly, the dominant Central European pattern, a starburst phylogeny around the modal sequence, T3, has a Neolithic origin, and the reduced diversity within this cluster in the ancient samples accords with their shorter history of post-domestic accumulation of mutation.

  8. Gathering the forgotten voices: an oral history of the CFHT's early years

    Science.gov (United States)

    Laychak, Mary Beth; Bryson, Liz

    2011-06-01

    They came to the Big Island from as far away as Murrumbeena, Australia, and as near by as Hilo, Hawaii. They were progeny of Scottish coal miners, French physicists, Chicago truck drivers, Japanese samurai and Big Island cane workers. Together, these men and women would build and commission one of the most dynamic and productive 3.6 meter telescopes in the world that remains in the forefront of science and technology. The CFHT oral history DVD preserves the stories of the first decade and a half of the observatory.

  9. Space-based gravitational-wave detectors can determine the thermal history of the early Universe

    International Nuclear Information System (INIS)

    Nakayama, Kazunori; Saito, Shun; Suwa, Yudai; Yokoyama, Jun'ichi

    2008-01-01

    It is shown that space-based gravitational-wave detectors such as DECIGO and/or the Big Bang Observer will provide us with invaluable information on the cosmic thermal history after inflation, and they will be able to determine the reheat temperature T R provided that it lies in the range preferred by the cosmological gravitino problem, T R ∼10 5-9 GeV. Therefore it is strongly desired that they will be put into practice as soon as possible

  10. Clostridium difficile infection: Early history, diagnosis and molecular strain typing methods.

    Science.gov (United States)

    Rodriguez, C; Van Broeck, J; Taminiau, B; Delmée, M; Daube, G

    2016-08-01

    Recognised as the leading cause of nosocomial antibiotic-associated diarrhoea, the incidence of Clostridium difficile infection (CDI) remains high despite efforts to improve prevention and reduce the spread of the bacterium in healthcare settings. In the last decade, many studies have focused on the epidemiology and rapid diagnosis of CDI. In addition, different typing methods have been developed for epidemiological studies. This review explores the history of C. difficile and the current scope of the infection. The variety of available laboratory tests for CDI diagnosis and strain typing methods are also examined. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. The ATLAS3D Project - XXX. Star formation histories and stellar population scaling relations of early-type galaxies

    Science.gov (United States)

    McDermid, Richard M.; Alatalo, Katherine; Blitz, Leo; Bournaud, Frédéric; Bureau, Martin; Cappellari, Michele; Crocker, Alison F.; Davies, Roger L.; Davis, Timothy A.; de Zeeuw, P. T.; Duc, Pierre-Alain; Emsellem, Eric; Khochfar, Sadegh; Krajnović, Davor; Kuntschner, Harald; Morganti, Raffaella; Naab, Thorsten; Oosterloo, Tom; Sarzi, Marc; Scott, Nicholas; Serra, Paolo; Weijmans, Anne-Marie; Young, Lisa M.

    2015-04-01

    We present the stellar population content of early-type galaxies from the ATLAS3D survey. Using spectra integrated within apertures covering up to one effective radius, we apply two methods: one based on measuring line-strength indices and applying single stellar population (SSP) models to derive SSP-equivalent values of stellar age, metallicity, and alpha enhancement; and one based on spectral fitting to derive non-parametric star formation histories, mass-weighted average values of age, metallicity, and half-mass formation time-scales. Using homogeneously derived effective radii and dynamically determined galaxy masses, we present the distribution of stellar population parameters on the Mass Plane (MJAM, σe, R^maj_e), showing that at fixed mass, compact early-type galaxies are on average older, more metal-rich, and more alpha-enhanced than their larger counterparts. From non-parametric star formation histories, we find that the duration of star formation is systematically more extended in lower mass objects. Assuming that our sample represents most of the stellar content of today's local Universe, approximately 50 per cent of all stars formed within the first 2 Gyr following the big bang. Most of these stars reside today in the most massive galaxies (>1010.5 M⊙), which themselves formed 90 per cent of their stars by z ˜ 2. The lower mass objects, in contrast, have formed barely half their stars in this time interval. Stellar population properties are independent of environment over two orders of magnitude in local density, varying only with galaxy mass. In the highest density regions of our volume (dominated by the Virgo cluster), galaxies are older, alpha-enhanced, and have shorter star formation histories with respect to lower density regions.

  12. Subsurface water and clay mineral formation during the early history of Mars.

    Science.gov (United States)

    Ehlmann, Bethany L; Mustard, John F; Murchie, Scott L; Bibring, Jean-Pierre; Meunier, Alain; Fraeman, Abigail A; Langevin, Yves

    2011-11-02

    Clay minerals, recently discovered to be widespread in Mars's Noachian terrains, indicate long-duration interaction between water and rock over 3.7 billion years ago. Analysis of how they formed should indicate what environmental conditions prevailed on early Mars. If clays formed near the surface by weathering, as is common on Earth, their presence would indicate past surface conditions warmer and wetter than at present. However, available data instead indicate substantial Martian clay formation by hydrothermal groundwater circulation and a Noachian rock record dominated by evidence of subsurface waters. Cold, arid conditions with only transient surface water may have characterized Mars's surface for over 4 billion years, since the early-Noachian period, and the longest-duration aqueous, potentially habitable environments may have been in the subsurface.

  13. The role of impacts in the history of the early earth

    Science.gov (United States)

    French, Bevan M.

    1991-01-01

    The significant conclusions of a conference called 'Meteorite Impact and the Early Earth' are reported including data which support the notion that extraterrestrial impacts greatly influenced the development of the earth. The cratering of other planetary surfaces is discussed, and the energy added by meteorite impacts is characterized. The primary effects of large impacts are set forth in terms of atmospheric, oceanic, and biological considerations which suggest that the ramifications would have been significant. Contentious issues include the variation of impact rate with time in the early universe, the interpretation of the record of intense bombardment in the lunar highlands, and the effects related to alternative scenarios. Directions of future study are mentioned including the identification of terrestrial impact structures, conducting searches in the Archean, and assessing ancient impact rates.

  14. Connecting the Indies: the hispano-asian Pacific world in early Modern Global History

    Directory of Open Access Journals (Sweden)

    Ryan Dominic Crewe

    Full Text Available Abstract This article reconsiders the place of colonial Latin America in global history by examining the Transpacific interactions, conflicts, and exchanges between Latin America and Asia in the sixteenth and seventeenth centuries. Setting aside earlier imperial histories that present the Pacific as a 'Spanish Lake', I conceptualize a dynamic Hispano-Asian Pacific World that was forged by a myriad of actors in and around the Pacific basin. Instead of a Pacific dominated by far-off Spain, my research reveals a Transpacific world that in fact defied imperial efforts to claim, regulate, or convert it. I structure this study along three broad lines of inquiry: the economic ties that made the Asian-Latin American 'Rim', the consequences of human transits and cultural exchanges along new Transpacific conduits, and the barriers of distance and culture that limited both cosmopolitanism and imperialism. For societies in Latin America, this Hispano-Asian Pacific world provided them with greater autonomy than the Atlantic world. They shared, alongside diverse groups in this maritime world, a common story of circumvention, of freewheeling exchanges, and of checked powers, for no single shoreline, empire, or group predominated. Ultimately, by charting the currents of Hispano-Asian interactions in the Pacific world, I provide a riposte to theories in global historiography that have situated Latin America at the periphery of Western Europe.

  15. Detrital zircon ages in Buller and Takaka terranes, New Zealand : constraints on early Zealandia history

    International Nuclear Information System (INIS)

    Adams, C.J.; Mortimer, N.; Campbell, H.J.; Griffin, W.L.

    2015-01-01

    Detrital zircon ages are presented for 34 early Palaeozoic sandstones from Buller and Takaka terranes, New Zealand, and formerly adjacent parts of Australia-Antarctica. The Buller-Takaka datasets always have two major groups: Ordovician-late Neoproterozoic, 444-700 Ma (but mainly 540-700 Ma), termed 'Gondwana Assembly' (GA), and early Neoproterozoic-Mesoproterozoic, 700-1600 Ma (but mainly 900-1200 Ma), termed 'Rodinia Assembly' (RA). In both terranes, significant age components within these groups are strikingly similar and also have RA/GA ratios, 0.6-1.8. The Cambrian volcanic arc of the Takaka Terrane has contributed little to the zircon patterns. Proportions of Late Cambrian-Early Ordovician zircons, characteristic of granitoid sources in the Ross-Delamerian Orogen are low. The zircons are predominantly reworked with contemporary zircons only evident in a few Buller datasets. The zircon patterns suggest that two major sources (late Mesoproterozoic and late Neoproterozoic), enduring over 120 Ma, were widely distributed and it is postulated they form Precambrian basement beneath southern Zealandia. (author).

  16. The founding of Zemun Hospital

    Directory of Open Access Journals (Sweden)

    Milanović Jasmina

    2014-01-01

    Full Text Available This year Zemun Hospital - Clinical Hospital Center Zemun celebrates 230th anniversary of continuous work, thus becoming the oldest medical facility in Serbia. The exact date of the hospital founding has been often questioned in history. Various dates appeared in the literature, but the most frequent one was 25th of February 1784. Until now, the document which confirms this has never been published. This article represents the first official publication of the document which confirms that Zemun Hospital was indeed founded on this date. The first hospitals started emerging in Zemun when the town became a part of the Habsburg Monarchy. The first sanitary facility ever formed was the “Kontumac” - a quarantine established in 1730. Soon after, two more confessional hospitals were opened. The Serbian (Orthodox Hospital was founded before 1769, whereas the German (Catholic Hospital started working in 1758. Both hospitals were financed, amongst others, by the Town Hall - the Magistrate. In order to improve efficiency of these hospitals, a decision was made to merge them into a single City Hospital. It was founded on 25th February 1784, when the General Command ordered the Magistrate of Zemun to merge the financess of all existing hospitals and initiate the construction of a new building. Although financially united, the hospitals continued working in separate buildings over a certain period of time. The final, physical merging of these hospitals was completed in 1795. [Projekat Ministarstva nauke Republike Srbije, br. 47030

  17. Early Stress History Alters Serum Insulin-Like Growth Factor-1 and Impairs Muscle Mitochondrial Function in Adult Male Rats.

    Science.gov (United States)

    Ghosh, S; Banerjee, K K; Vaidya, V A; Kolthur-Seetharam, U

    2016-09-01

    Early-life adversity is associated with an enhanced risk for adult psychopathology. Psychiatric disorders such as depression exhibit comorbidity for metabolic dysfunction, including obesity and diabetes. However, it is poorly understood whether, besides altering anxiety and depression-like behaviour, early stress also evokes dysregulation of metabolic pathways and enhances vulnerability for metabolic disorders. We used the rodent model of the early stress of maternal separation (ES) to examine the effects of early stress on serum metabolites, insulin-like growth factor (IGF)-1 signalling, and muscle mitochondrial content. Adult ES animals exhibited dyslipidaemia, decreased serum IGF1 levels, increased expression of liver IGF binding proteins, and a decline in the expression of specific metabolic genes in the liver and muscle, including Pck1, Lpl, Pdk4 and Hmox1. These changes occurred in the absence of alterations in body weight, food intake, glucose tolerance, insulin tolerance or insulin levels. ES animals also exhibited a decline in markers of muscle mitochondrial content, such as mitochondrial DNA levels and expression of TFAM (transcription factor A, mitochondrial). Furthermore, the expression of several genes involved in mitochondrial function, such as Ppargc1a, Nrf1, Tfam, Cat, Sesn3 and Ucp3, was reduced in skeletal muscle. Adult-onset chronic unpredictable stress resulted in overlapping and distinct consequences from ES, including increased circulating triglyceride levels, and a decline in the expression of specific metabolic genes in the liver and muscle, with no change in the expression of genes involved in muscle mitochondrial function. Taken together, our results indicate that a history of early adversity can evoke persistent changes in circulating IGF-1 and muscle mitochondrial function and content, which could serve to enhance predisposition for metabolic dysfunction in adulthood. © 2016 British Society for Neuroendocrinology.

  18. Early evolution of the earth - Accretion, atmosphere formation, and thermal history

    Science.gov (United States)

    Abe, Yutaka; Matsui, Takafumi

    1986-01-01

    The thermal and atmospheric evolution of the earth growing planetesimal impacts are studied. The generation of an H2O protoatmosphere is examined, and the surface temperatures are estimated. The evolution of an impact-induced H2O atmosphere is analyzed. Consideration is given to the formation time of a 'magma ocean'and internal water budgets. The thermal history of an accreting earth is reviewed. The wet convection and greenhouse effects are discussed, and the role of Fe oxidation on the evolution of an impact-induced H2O atmopshere is described. The relationship between differentiation processes and core segregation, the H2O and FeO content of the mantle, and the origin of the hydrosphere is also examined.

  19. Constraining the temperature history of the past millennium using early instrumental observations

    Directory of Open Access Journals (Sweden)

    P. Brohan

    2012-10-01

    Full Text Available The current assessment that twentieth-century global temperature change is unusual in the context of the last thousand years relies on estimates of temperature changes from natural proxies (tree-rings, ice-cores, etc. and climate model simulations. Confidence in such estimates is limited by difficulties in calibrating the proxies and systematic differences between proxy reconstructions and model simulations. As the difference between the estimates extends into the relatively recent period of the early nineteenth century it is possible to compare them with a reliable instrumental estimate of the temperature change over that period, provided that enough early thermometer observations, covering a wide enough expanse of the world, can be collected.

    One organisation which systematically made observations and collected the results was the English East India Company (EEIC, and their archives have been preserved in the British Library. Inspection of those archives revealed 900 log-books of EEIC ships containing daily instrumental measurements of temperature and pressure, and subjective estimates of wind speed and direction, from voyages across the Atlantic and Indian Oceans between 1789 and 1834. Those records have been extracted and digitised, providing 273 000 new weather records offering an unprecedentedly detailed view of the weather and climate of the late eighteenth and early nineteenth centuries.

    The new thermometer observations demonstrate that the large-scale temperature response to the Tambora eruption and the 1809 eruption was modest (perhaps 0.5 °C. This provides an out-of-sample validation for the proxy reconstructions – supporting their use for longer-term climate reconstructions. However, some of the climate model simulations in the CMIP5 ensemble show much larger volcanic effects than this – such simulations are unlikely to be accurate in this respect.

  20. Beatrice Hinkle and the Early History of Jungian Psychology in New York

    Directory of Open Access Journals (Sweden)

    Jay Sherry

    2013-08-01

    Full Text Available As the leading proponent of psychoanalysis, Jung made trips to New York in 1912 and 1913. The first was to give his Fordham lectures, the second has escaped notice but was crucial in the early dissemination of Jungian psychology in the U.S. This paper will elaborate on this development by highlighting the career and influence of Beatrice Hinkle, the country’s first Jungian psychoanalyst. She was an M.D. and ardent feminist who introduced Jung to her Greenwich Village circle, translated his magnum opus Transformations and Symbols of the Libido, and helped establish the institutional basis of Jungian psychology in America.

  1. The concept of suggestion in the early history of advertising psychology.

    Science.gov (United States)

    Kuna, D P

    1976-10-01

    As early as 1896, experimental psychologists began studying the mental processes involved in advertising. The first psychological theory of advertising maintained, in effect, that the consumer was a nonrational, suggestible creature under the hypnotic influence of the advertising copywriter. Walter Dill Scott was the major proponent of this theory, and it was largely through his writings that advertising men learned about the psychology of suggestion. Scott's theory was consistent with a growing trend in the advertising profession toward viewing consumer behavior as irrational. Scott's efforts might also be viewed as part of the trend in the advertising profession toward seeking a scientific basis for copywriting theory and practice.

  2. Beatrice Hinkle and the Early History of Jungian Psychology in New York

    Science.gov (United States)

    Sherry, Jay

    2013-01-01

    As the leading proponent of psychoanalysis, Jung made trips to New York in 1912 and 1913. The first was to give his Fordham lectures, the second has escaped notice but was crucial in the early dissemination of Jungian psychology in the U.S. This paper will elaborate on this development by highlighting the career and influence of Beatrice Hinkle, the country’s first Jungian psychoanalyst. She was an M.D. and ardent feminist who introduced Jung to her Greenwich Village circle, translated his magnum opus Transformations and Symbols of the Libido, and helped establish the institutional basis of Jungian psychology in America. PMID:25379251

  3. Lovers, enemies, and friends: The complex and coded early history of lesbian comic strip characters.

    Science.gov (United States)

    McGurk, Caitlin

    2018-05-31

    This article seeks to recuperate four previously unexamined early newspaper comic strip characters that could lay the groundwork for queer comic studies. The titular characters in Lucy and Sophie Say Goodbye (1905), Sanjak in Terry and the Pirates (1939) by Milton Caniff, and Hank O'Hair in Brenda Starr, Reporter (1940) by Dale Messick are analyzed through close readings, supporting archival material, and interviews. The article also theorizes the identification of the creator of Lucy and Sophie Say Goodbye as George O. Frink, and offers an overview of LGBTQ comics holdings at institutions in North America.

  4. Revisiting Einstein's Happiest Thought: On Ernst Mach and the Early History of Relativity

    Science.gov (United States)

    Staley, Richard

    2016-03-01

    This paper argues we should distinguish three phases in the formation of relativity. The first involved relational approaches to perception, and physiological and geometrical space and time in the 1860s and 70s. The second concerned electrodynamics and mechanics (special relativity). The third concerned mechanics, gravitation, and physical and geometrical space and time. Mach's early work on the Doppler effect, together with studies of visual and motor perception linked physiology, physics and psychology, and offered new approaches to physiological space and time. These informed the critical conceptual attacks on Newtonian absolutes that Mach famously outlined in The Science of Mechanics. Subsequently Mach identified a growing group of ``relativists,'' and his critiques helped form a foundation for later work in electrodynamics (in which he did not participate). Revisiting Mach's early work will suggest he was still more important to the development of new approaches to inertia and gravitation than has been commonly appreciated. In addition to what Einstein later called ``Mach's principle,'' I will argue that a thought experiment on falling bodies in Mach's Science of Mechanics also provided a point of inspiration for the happy thought that led Einstein to the equivalence principle.

  5. A gravid lizard from the Cretaceous of China and the early history of squamate viviparity

    Science.gov (United States)

    Wang, Yuan; Evans, Susan E.

    2011-09-01

    Although viviparity is most often associated with mammals, roughly one fifth of extant squamate reptiles give birth to live young. Phylogenetic analyses indicate that the trait evolved more than 100 times within Squamata, a frequency greater than that of all other vertebrate clades combined. However, there is debate as to the antiquity of the trait and, until now, the only direct fossil evidence of squamate viviparity was in Late Cretaceous mosasauroids, specialised marine lizards without modern equivalents. Here, we document viviparity in a specimen of a more generalised lizard, Yabeinosaurus, from the Early Cretaceous of China. The gravid female contains more than 15 young at a level of skeletal development corresponding to that of late embryos of living viviparous lizards. This specimen documents the first occurrence of viviparity in a fossil reptile that was largely terrestrial in life, and extends the temporal distribution of the trait in squamates by at least 30 Ma. As Yabeinosaurus occupies a relatively basal position within crown-group squamates, it suggests that the anatomical and physiological preconditions for viviparity arose early within Squamata.

  6. The Early Awareness and Alert System in Sweden: History and Current Status

    Directory of Open Access Journals (Sweden)

    Irene Eriksson

    2017-10-01

    Full Text Available Introduction: Over the past decades, early awareness and alert (EAA activities and systems have gained importance and become a key early health technology assessment (HTA tool. While a pioneer in HTA, Sweden had no national level EAA activities until 2010. We describe the evolution and current status of the Swedish EAA System.Methods: This was a historical analysis based on the knowledge and experience of the authors supplemented by a targeted review of published and gray literature as well as documents relating to EAA activities in Sweden. Key milestones and a description of the current state of the Swedish EAA System is presented.Results: Initiatives to establish a system for the identification and assessment of emerging health technologies in Sweden date back to the 1980s. In the 1990s, the Swedish Agency for HTA and Assessment of Social Services (SBU supported the development of EuroScan as one of its founder members. In the mid-2000s, an independent regional initiative, driven by the Stockholm County Drug and Therapeutics Committee, resulted in the establishment of a regional horizon scanning function. By 2009, this work had expanded to a collaboration between the four biggest counties in Sweden. The following year it was further expanded to the national level and since then the Swedish EAA System has been carrying out identification, filtration and prioritization of new medicines, early assessment of the prioritized medicines, and dissemination of information. In 2015, the EAA System was incorporated into the Swedish national process for managed introduction and follow-up of new medicines. Outputs from the EAA System are now used to select new medicines for inclusion in this process.Conclusions: The Swedish EAA System started as a regional initiative and rapidly grew to become a national level activity. An important feature of the system today is its complete integration into the national process for managed introduction and follow-up of

  7. Connectivity in the early life history of sandeel inferred from otolith microchemistry

    Science.gov (United States)

    Gibb, Fiona M.; Régnier, Thomas; Donald, Kirsty; Wright, Peter J.

    2017-01-01

    Connectivity is a central issue in the development, sustainability and effectiveness of networks of Marine Protected Areas (MPAs). In populations with site attached adults, connectivity is limited to dispersal in the pelagic larval stage. While biophysical models have been widely used to infer early dispersal, empirical evidence through sources such as otolith microchemistry can provide a means of evaluating model predictions. In the present study, connectivity in the lesser sandeel, Ammodytes marinus, was investigated using LA-ICP-MS otolith microchemistry. Otoliths from juveniles (age 0) were examined from four Scottish spawning areas predicted to differ in terms of larval retention rates and connectivity based on past biophysical models. There were significant spatial differences in otolith post-settled juvenile chemistry among locations at a scale of 100-400 km. Differences in near core chemistry pointed to three chemically distinct natal sources, as identified by a cluster analysis, contributing to settlement locations.

  8. Human radiation studies: Remembering the early years. Oral history of Julie Langham Grilly, February 3, 1995

    International Nuclear Information System (INIS)

    1995-09-01

    Julie Langham Grilly was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE) being the widow of Dr. Wright Langham, an investigator of principal interest of the committee. Her extensive experience with research at LANL was also of interest to the committee. Following a brief biographical sketch, Ms. Grilly relates her early postwar experience and her knowledge of Wright Langham's involvement in animal research at Los Alamos, radiolanthanum tests on monkeys, Eniwetok tissue examinations, research on tritium uptake in humans, plutonium injections, tritium injections, EDTA, and etc. In addition to illuminating her former husband as a researcher and as an individual, she also relates her remembrances of Louis Hempelman, Enrico Fermi, Oppenheimer, Edward Teller, and many others

  9. Human radiation studies: Remembering the early years. Oral history of Julie Langham Grilly, February 3, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    Julie Langham Grilly was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE) being the widow of Dr. Wright Langham, an investigator of principal interest of the committee. Her extensive experience with research at LANL was also of interest to the committee. Following a brief biographical sketch, Ms. Grilly relates her early postwar experience and her knowledge of Wright Langham`s involvement in animal research at Los Alamos, radiolanthanum tests on monkeys, Eniwetok tissue examinations, research on tritium uptake in humans, plutonium injections, tritium injections, EDTA, and etc. In addition to illuminating her former husband as a researcher and as an individual, she also relates her remembrances of Louis Hempelman, Enrico Fermi, Oppenheimer, Edward Teller, and many others.

  10. A Preliminary Report on the Early History and Archaeology of Kahauale'A, Puna, Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, Tommy

    1982-04-14

    The following is a report on the findings of a documentary literature search on the ahupuaa of Kahauale'a in the Puna District of the island of Hawaii. Attention is given to the entirety of the ahupuaa, though the emphasis is on the mauka portions from about 1,500 to 3,800-feet elevation, or roughly three miles inland to the northern terminus of the ahupuaa, just below Kilauea. The report was commissioned by The Estate of James Campbell for purposes of ascertaining what the extent of early Hawaiian activities and/or habitation occurred in the mauka regions of Kahauale'a--specifically to see if proposed geothermal drilling activities in these areas would disturb any archaeological sites.

  11. Principles, exemplars, and uses of history in early 20th century genetics.

    Science.gov (United States)

    Skopek, Jeffrey M

    2011-06-01

    This paper is concerned with the uses of history in science. It focuses in particular on Anglo-American genetics and on university textbooks--where the canon of a science is consolidated, as the heterogeneous approaches and controversies of its practice are rendered unified for its reproduction. Tracing the emergence and eventual standardization of geneticists' use of a case-based method of teaching in the 1920s-1950s, this paper argues that geneticists created historical environments in their textbooks-spaces in which students developed an understanding of the laws of genetics through simulations of their discovery and use. Witnessing the unfolding of Mendel's and Morgan's experiments and performing genetic crosses on paper, students learned not only the rules that were explicitly taught as such, but also the experientially-based, tacit skills needed to find and follow these rules. This didactic system taught them how to go on when confronting new situations, and in doing so, provided geneticists with an important disciplinary tool, freeing the first steps of their student's enculturation from the physical infrastructure of the laboratory. Copyright © 2010 Elsevier Ltd. All rights reserved.

  12. Effects of coal contamination on early life history processes of a reef-building coral, Acropora tenuis.

    Science.gov (United States)

    Berry, Kathryn L E; Hoogenboom, Mia O; Brinkman, Diane L; Burns, Kathryn A; Negri, Andrew P

    2017-01-15

    Successful reproduction and larval dispersal are important for the persistence of marine invertebrate populations, and these early life history processes can be sensitive to marine pollution. Coal is emerging as a contaminant of interest due to the proximity of ports and shipping lanes to coral reefs. To assess the potential hazard of this contaminant, gametes, newly developed embryos, larvae and juveniles of the coral Acropora tenuis were exposed to a range of coal leachate, suspended coal, and coal smothering treatments. Fertilisation was the most sensitive reproductive process tested. Embryo survivorship decreased with increasing suspended coal concentrations and exposure duration, effects on larval settlement varied between treatments, while effects on juvenile survivorship were minimal. Leachate exposures had negligible effects on fertilisation and larval settlement. These results indicate that coral recruitment could be affected by spills that produce plumes of suspended coal particles which interact with gametes and embryos soon after spawning. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  13. A short history of wind power - from its early beginnings to today's installations and its business environment

    International Nuclear Information System (INIS)

    2005-01-01

    This article takes a look at how wind power has developed from its beginnings centuries ago with windmills over early installations in Denmark around 1900 through to the modern wind-parks providing many thousands of megawatts of wind power generated by 100-metre-high units with installed power ratings of up to 5 megawatts. The history of wind power is looked at from the simple windmill to the modern, industrially manufactured mass product. The expected growth of the wind-power market in the twenty-first century is discussed, as are the legal regulations governing their construction and use. Figures are also given on production capacities and installed power in various countries

  14. Church History and the Predicament of the Orthodox Hierarchy in the Russian Empire of the Early 1800s

    Directory of Open Access Journals (Sweden)

    Eugene I. Lyutko

    2017-12-01

    Full Text Available In this article, the author tries to reflect the emergence of the intellectual concept of “Church History” through a number of theoretical frameworks, setting this discursive turn on the map of the epoch using several narratives. The first is the problem of the cultural gap arising during the 18th century between the intellectual elites of the nobility and clergy. Second, we examine the bureaucratization of the empire leading both to the convergence of parallel “ecclesiastical” and “civil” administrative structures and to the emergence of the bureaucratic layer between episcopate and the monarch, who was considered as the formal “head” of the earthly ecclesiastical structure. Third, we consider the establishment of the administrative bonds between governmental authorities and individuals, which were understood as being in competition for the “pastoral” power of the church hierarchy. We next examine the change in the mode of knowledge distribution, which took place within the emergence of the “public sphere” in the early 19th-century Russian Empire. Finally, we look at the problem of the national identity emerging in the late 18th and early 19th centuries, which was centered around the concept of the ethnic community and political body (and its history rather than on the community of believers actualized in the discourse of the epoch as the concept of Church (and its history. All those narratives on social change strive to explain the global change in Orthodox theology, which became centered on ecclesiology. This change might be effectively problematized as a transition between first and second “orders of theology” within the framework proposed by G. Kaufman. This method of explanation may be especially productive when it comes to drawing an analogy between Russian and Western theology in the modern period.

  15. Local adaptation at the transcriptome level in brown trout: evidence from early life history temperature genomic reaction norms.

    Directory of Open Access Journals (Sweden)

    Kristian Meier

    Full Text Available Local adaptation and its underlying molecular basis has long been a key focus in evolutionary biology. There has recently been increased interest in the evolutionary role of plasticity and the molecular mechanisms underlying local adaptation. Using transcriptome analysis, we assessed differences in gene expression profiles for three brown trout (Salmo trutta populations, one resident and two anadromous, experiencing different temperature regimes in the wild. The study was based on an F2 generation raised in a common garden setting. A previous study of the F1 generation revealed different reaction norms and significantly higher QST than FST among populations for two early life-history traits. In the present study we investigated if genomic reaction norm patterns were also present at the transcriptome level. Eggs from the three populations were incubated at two temperatures (5 and 8 degrees C representing conditions encountered in the local environments. Global gene expression for fry at the stage of first feeding was analysed using a 32k cDNA microarray. The results revealed differences in gene expression between populations and temperatures and population × temperature interactions, the latter indicating locally adapted reaction norms. Moreover, the reaction norms paralleled those observed previously at early life-history traits. We identified 90 cDNA clones among the genes with an interaction effect that were differently expressed between the ecologically divergent populations. These included genes involved in immune- and stress response. We observed less plasticity in the resident as compared to the anadromous populations, possibly reflecting that the degree of environmental heterogeneity encountered by individuals throughout their life cycle will select for variable level of phenotypic plasticity at the transcriptome level. Our study demonstrates the usefulness of transcriptome approaches to identify genes with different temperature reaction

  16. Early life history of three pelagic-spawning minnows Macrhybopsis spp. in the lower Missouri River

    Science.gov (United States)

    Long, James M.; Starks, Trevor A.; Miller, M.L.

    2016-01-01

    Life-history characteristics of age-0 sturgeon chub Macrhybopsis gelida, shoal chub Macrhybopsis hyostoma and sicklefin chub Macrhybopsis meeki were compared using several methods. AllMacrhybopsis species consumed mostly midge pupae, but M. meeki had the most general diet (Levins' index, B = 0·22) compared with M. hyostoma (B = 0·02) and M. gelida (B = 0·09). Morisita's diet overlap index among species pairs ranged from 0·62 to 0·97 and was highest between M. hyostoma and M. gelida. Daily ages estimated from lapilli otoliths for each species ranged from 15 to 43 days for M. gelida, 19 to 44 for M. hyostoma and from 16 to 64 days for M. meeki. Mean growth rates ranged from 0·79 mm day−1 for M. meeki to 1·39 mm day−1 for M. gelida. Mortality estimates indicated high daily survivorship rates for M. meeki (0·985), but could not be estimated for the other two species. Hatch date histograms were congruent with the belief that M. hyostoma and M. gelida spawn periodically from June to September. Macrhybopsis meeki, however, appeared to respond to a specific spawning cue as hatch dates were unimodal with a peak in July. These results fill a gap in current knowledge of these imperilled species that can be used to guide management decisions.

  17. Early history of glycine receptor biology in mammalian spinal cord circuits

    Directory of Open Access Journals (Sweden)

    Robert J Callister

    2010-05-01

    Full Text Available In this review we provide an overview of key in vivo experiments, undertaken in the cat spinal cord in the 1950s and 1960s, and point out their contributions to our present understanding of glycine receptor (GlyR function. Importantly, some of these discoveries were made well before an inhibitory receptor, or its agonist, was identified. These contributions include the universal acceptance of a chemical mode of synaptic transmission, that GlyRs are chloride channels, are involved in reciprocal and recurrent spinal inhibition, are selectively blocked by strychnine, and can be distinguished from the GABAA receptor by their insensitivity to bicuculline. The early in vivo work on inhibitory mechanisms in spinal neurons also contributed to several enduring principles on synaptic function, such as the time associated with synaptic delay, the extension of Dale’s hypothesis (regarding the chemical unity of nerve cells and their terminals to neurons within the central nervous system, and the importance of inhibition for synaptic integration in motor and sensory circuits. We hope the work presented here will encourage those interested in GlyR biology and inhibitory mechanisms to seek out and read some of the “classic” articles that document the above discoveries.

  18. A Jurassic avialan dinosaur from China resolves the early phylogenetic history of birds.

    Science.gov (United States)

    Godefroit, Pascal; Cau, Andrea; Dong-Yu, Hu; Escuillié, François; Wenhao, Wu; Dyke, Gareth

    2013-06-20

    The recent discovery of small paravian theropod dinosaurs with well-preserved feathers in the Middle-Late Jurassic Tiaojishan Formation of Liaoning Province (northeastern China) has challenged the pivotal position of Archaeopteryx, regarded from its discovery to be the most basal bird. Removing Archaeopteryx from the base of Avialae to nest within Deinonychosauria implies that typical bird flight, powered by the forelimbs only, either evolved at least twice, or was subsequently lost or modified in some deinonychosaurians. Here we describe the complete skeleton of a new paravian from the Tiaojishan Formation of Liaoning Province, China. Including this new taxon in a comprehensive phylogenetic analysis for basal Paraves does the following: (1) it recovers it as the basal-most avialan; (2) it confirms the avialan status of Archaeopteryx; (3) it places Troodontidae as the sister-group to Avialae; (4) it supports a single origin of powered flight within Paraves; and (5) it implies that the early diversification of Paraves and Avialae took place in the Middle-Late Jurassic period.

  19. Historical DNA reveals the demographic history of Atlantic cod (Gadus morhua) in medieval and early modern Iceland.

    Science.gov (United States)

    Ólafsdóttir, Guðbjörg Ásta; Westfall, Kristen M; Edvardsson, Ragnar; Pálsson, Snæbjörn

    2014-02-22

    Atlantic cod (Gadus morhua) vertebrae from archaeological sites were used to study the history of the Icelandic Atlantic cod population in the time period of 1500-1990. Specifically, we used coalescence modelling to estimate population size and fluctuations from the sequence diversity at the cytochrome b (cytb) and Pantophysin I (PanI) loci. The models are consistent with an expanding population during the warm medieval period, large historical effective population size (NE), a marked bottleneck event at 1400-1500 and a decrease in NE in early modern times. The model results are corroborated by the reduction of haplotype and nucleotide variation over time and pairwise population distance as a significant portion of nucleotide variation partitioned across the 1550 time mark. The mean age of the historical fished stock is high in medieval times with a truncation in age in early modern times. The population size crash coincides with a period of known cooling in the North Atlantic, and we conclude that the collapse may be related to climate or climate-induced ecosystem change.

  20. Evolutionary history of continental southeast Asians: "early train" hypothesis based on genetic analysis of mitochondrial and autosomal DNA data.

    Science.gov (United States)

    Jinam, Timothy A; Hong, Lih-Chun; Phipps, Maude E; Stoneking, Mark; Ameen, Mahmood; Edo, Juli; Saitou, Naruya

    2012-11-01

    The population history of the indigenous populations in island Southeast Asia is generally accepted to have been shaped by two major migrations: the ancient "Out of Africa" migration ∼50,000 years before present (YBP) and the relatively recent "Out of Taiwan" expansion of Austronesian agriculturalists approximately 5,000 YBP. The Negritos are believed to have originated from the ancient migration, whereas the majority of island Southeast Asians are associated with the Austronesian expansion. We determined 86 mitochondrial DNA (mtDNA) complete genome sequences in four indigenous Malaysian populations, together with a reanalysis of published autosomal single-nucleotide polymorphism (SNP) data of Southeast Asians to test the plausibility and impact of those migration models. The three Austronesian groups (Bidayuh, Selatar, and Temuan) showed high frequencies of mtDNA haplogroups, which originated from the Asian mainland ∼30,000-10,000 YBP, but low frequencies of "Out of Taiwan" markers. Principal component analysis and phylogenetic analysis using autosomal SNP data indicate a dichotomy between continental and island Austronesian groups. We argue that both the mtDNA and autosomal data suggest an "Early Train" migration originating from Indochina or South China around the late-Pleistocene to early-Holocene period, which predates, but may not necessarily exclude, the Austronesian expansion.

  1. BRCA1 and BRCA2 germline mutations in Malaysian women with early-onset breast cancer without a family history.

    Directory of Open Access Journals (Sweden)

    Gaik Theng Toh

    Full Text Available BACKGROUND: In Asia, breast cancer is characterised by an early age of onset: In Malaysia, approximately 50% of cases occur in women under the age of 50 years. A proportion of these cases may be attributable, at least in part, to genetic components, but to date, the contribution of genetic components to breast cancer in many of Malaysia's ethnic groups has not been well-characterised. METHODOLOGY: Given that hereditary breast carcinoma is primarily due to germline mutations in one of two breast cancer susceptibility genes, BRCA1 and BRCA2, we have characterised the spectrum of BRCA mutations in a cohort of 37 individuals with early-onset disease (history. Mutational analysis of BRCA1 and BRCA2 was conducted by full sequencing of all exons and intron-exon junctions. CONCLUSIONS: Here, we report a total of 14 BRCA1 and 17 BRCA2 sequence alterations, of which eight are novel (3 BRCA1 and 5 BRCA2. One deleterious BRCA1 mutation and 2 deleterious BRCA2 mutations, all of which are novel mutations, were identified in 3 of 37 individuals. This represents a prevalence of 2.7% and 5.4% respectively, which is consistent with other studies in other Asian ethnic groups (4-9%.

  2. Two possibilities for New Siberian Islands terrane tectonic history during the Early Paleozoic based on paleomagnetic data

    Science.gov (United States)

    Metelkin, Dmitry V.; Chernova, Anna I.; Vernikovsky, Valery A.; Matushkin, Nikolay Yu.

    2017-04-01

    The New Siberian Islands (NSI), located in the East Siberian Sea in the junction region of various structural elements, are a key target for deciphering the tectonic evolution of the Eastern Arctic. In recent years, we went on several expeditions and gathered an extensive geological material for this territory. Among other things, we could prove that the basement of the De Long and Anjou archipelagos structures is Precambrian and the overlying Paleozoic sections formed within the same terrane. The form of the boundaries of the NSI terrane are actively debated and are probably continued from the Lyakhovsky islands in the south-west to the southern parts of the submerged Mendeleev Ridge, for which there is increasing evidence of continental crust. Today there are several models that interpret the Paleozoic-Mesozoic tectonic history and structural affiliation of the NSI terrane. Some propose that the Paleozoic sedimentary section formed in a passive margin setting of the Siberian paleocontinent. Others compare its history with marginal basins of the Baltica and Laurentia continents or consider the NSI terrane as an element of the Chukotka-Alaska microplate. These models are mainly based on results of paleobiogeographical and lithological-facies analyses, including explanations of probable sources for detrital zircons. Our paleomagnetic research on sedimentary, volcanogenic-sedimentary and igneous rocks of the Anjou (Kotelny and Bel'kovsky islands) and De Long (Bennett, Jeannette and Henrietta islands) archipelagos let us calculate an apparent polar wander path for the early Paleozoic interval of geological history, which allows us to conclude that the NSI terrane could not have been a part of the continental plates listed above, but rather had active tectonic boundaries with them. Our paleomagnetic data indicate that the NSI terrane drifted slowly and steadily in the tropical and subtropical regions no higher than 40 degrees. However, the main uncertainty for the

  3. Contribution of outstanding teachers from Western Ukraine of late XIX – early XX century to development of theory and methods of teaching history

    Directory of Open Access Journals (Sweden)

    Zinoviia Nahachevska

    2017-02-01

    Full Text Available The article provides analysis of theses from works of prominent representatives of educational thought in Western Ukraine of late XIX – early XX century, which are related to solving problems of teaching history in elementary and secondary schools in the region. The emphasis is placed on the actualization of content and methods of teaching by V. VilshanetskaZhukovetska, A. Kopystianskyi, M. Korduba, and K. Malytska.Key words: elementary and secondary schools (gymnasia, curricula, content, principles and methods of teaching history, school textbooks, anthropologization and humanization of history, study of local lore.

  4. Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with depressive disorder and healthy controls.

    Science.gov (United States)

    Bandelow, Borwin; Gutermann, Julia; Peter, Helmut; Wedekind, Dirk

    2013-02-01

    Only few studies have compared the frequency of traumatic life events during childhood in inpatients with depression with a healthy control group. Consecutively admitted inpatients with depression (n = 79), most of whom belonged to the melancholic subtype (n = 73; 92.4%), and healthy controls (n = 110) were investigated using a comprehensive retrospective interview with 203 questions regarding childhood traumatic life events, parental attitudes, family history of psychiatric disorders and birth risk factors. Depressed patients had significantly more severe traumatic events (mean score 1.33; SD 1.4) than control subjects (0.85; SD 1.2) on a 0-10 point "severe trauma scale". 70.9% (n = 56) of the depressed patients, but only 48.2% (n = 53) of the controls reported at least one severe traumatic event. When looking at single events, only few differences were found between patients and controls. Compared to controls, patients described significantly higher rates of psychiatric disorders in their families, in particular depression. Parental rearing styles were rated as more unfavorable in the patient group. In a logistic regression model, of all possible etiological factors examined, only a family history of psychiatric disorders showed a significant influence (OR = 3.6). Melancholic depression seems to be less associated with traumatic events than other psychiatric disorders.

  5. Effects of food restriction across stages of juvenile and early adult development on body weight, survival and adult life history.

    Science.gov (United States)

    Wong, J W Y; Kölliker, M

    2014-11-01

    Organisms have to allocate limited resources among multiple life-history traits, which can result in physiological trade-offs, and variation in environmental conditions experienced during ontogeny can influence reproduction later in life. Food restriction may lead to an adaptive reallocation of the limited resources among traits as a phenotypically plastic adjustment, or it can act as an overall constraint with detrimental effects throughout reproductive life. In this study, we investigated experimentally the effects of food restriction during different stages of the juvenile and early adult development on body weight, survival and reproductive success in females and males of the European earwig Forficula auricularia. Individuals either received limited or unlimited access to food across three different stages of development (fully crossed) allowing us to identify sensitive periods during development and to test both additive and interactive effects of food limitation across stages on development and reproduction. Food restriction during the early and late juvenile stage had additive negative effects on juvenile survival and adult body weight. With regard to reproductive success of females which produce up to two clutches in their lifetime, restriction specifically in the late juvenile stage led to smaller first and second clutch size, lower probability of second clutch production and reduced hatching success in the second clutch. Reproductive success of females was not significantly affected when their male mates experienced food restriction during their development. Our findings in general support the 'silver-spoon' hypothesis in that food restriction during juvenile development poses constraints on development and reproduction throughout life. © 2014 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2014 European Society For Evolutionary Biology.

  6. The Hidden History of a Famous Drug : Tracing the Medical and Public Acculturation of Peruvian Bark in Early Modern Western Europe (c. 1650-1720)

    NARCIS (Netherlands)

    Klein, Wouter; Pieters, Toine

    2016-01-01

    The history of the introduction of exotic therapeutic drugs in early modern Europe is usually rife with legend and obscurity and Peruvian bark is a case in point. The famous antimalarial drug entered the European medical market around 1640, yet it took decades before the bark was firmly established

  7. Columbia River White Sturgeon Genetics and Early Life History: Population Segregation and Juvenile Feeding Behavior, 1987 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Brannon, Ernest L.

    1988-06-01

    The geographic area of the genetics study broadly covered the distribution range of sturgeon in the Columbia from below Bonneville Dam at Ilwaco at Lake Roosevelt, the Upper Snake River, and the Kootenai River. The two remote river sections provided data important for enhancement considerations. There was little electrophoretic variation seen among individuals from the Kootenai River. Upper Snake river sturgeon showed a higher percentage of polymorphic loci than the Kootenai fish, but lower than the other areas in the Columbia River we sampled. Sample size was increased in both Lake Roosevelt and at Electrophoretic variation was specific to an individual sampling area in several cases and this shaped our conclusions. The 1987 early life history studies concentrated on the feeding behavior of juvenile sturgeon. The chemostimulant components in prey attractive to sturgeon were examined, and the sensory systems utilized by foraging sturgeon were determined under different environmental conditions. These results were discussed with regard to the environmental changes that have occurred in the Columbia River. Under present river conditions, the feeding mechanism of sturgeon is more restricted to certain prey types, and their feeding range may be limited. In these situations, enhancement measures cannot be undertaken without consideration given to the introduction of food resources that will be readily available under present conditions. 89 refs., 7 figs., 11 tabs.

  8. Morphometric analysis of chameleon fossil fragments from the Early Pliocene of South Africa: a new piece of the chamaeleonid history.

    Science.gov (United States)

    Dollion, Alexis Y; Cornette, Raphaël; Tolley, Krystal A; Boistel, Renaud; Euriat, Adelaïde; Boller, Elodie; Fernandez, Vincent; Stynder, Deano; Herrel, Anthony

    2015-02-01

    The evolutionary history of chameleons has been predominantly studied through phylogenetic approaches as the fossil register of chameleons is limited and fragmented. The poor state of preservation of these fossils has moreover led to the origin of numerous nomen dubia, and the identification of many chameleon fossils remains uncertain. We here examine chameleon fossil fragments from the Early Pliocene Varswater formation, exposed at the locality of Langebaanweg "E" Quarry along the southwestern coast of South Africa. Our aim was to explore whether these fossil fragments could be assigned to extant genera. To do so, we used geometric morphometric approaches based on microtomographic imaging of extant chameleons as well as the fossil fragments themselves. Our study suggests that the fossils from this deposit most likely represent at least two different forms that may belong to different genera. Most fragments are phenotypically dissimilar from the South African endemic genus Bradypodion and are more similar to other chameleon genera such as Trioceros or Kinyongia. However, close phenetic similarities between some of the fragments and the Seychelles endemic Archaius or the Madagascan genus Furcifer suggest that some of these fragments may not contain enough genus-specific information to allow correct identification. Other fragments such as the parietal fragments appear to contain more genus-specific information, however. Although our data suggest that the fossil diversity of chameleons in South Africa was potentially greater than it is today, this remains to be verified based on other and more complete fragments.

  9. The wondrous eyes of a new technology – A history of the early electroencephalography (EEG of psychopathy, delinquency, and immorality

    Directory of Open Access Journals (Sweden)

    Felix eSchirmann

    2014-04-01

    Full Text Available This article presents a history of the early electroencephalography (EEG of psychopathy, delinquency, and immorality in Great Britain and the United States in the 1940s and 1950s. Then, EEG was a novel research tool that promised ground-breaking insights in psychiatry and criminology. Experts explored its potential regarding the diagnosis, classification, etiology, and treatment of unethical and unlawful persons. This line of research yielded tentative and inconsistent findings, which the experts attributed to methodological and theoretical shortcomings. Accordingly, the scientific community discussed the reliability, validity, and utility of EEG, and launched initiatives to calibrate and standardize the novel tool. The analysis shows that knowledge production, gauging of the research tool, and attempts to establish credibility for EEG in the study of immoral persons occurred simultaneously. The paper concludes with a reflection on the similarities between EEG and neuroimaging – the prime research tool in the current neuroscience of morality – and calls for a critical assessment of their potentials and limitations in the study of immorality and crime.

  10. "The wondrous eyes of a new technology"-a history of the early electroencephalography (EEG) of psychopathy, delinquency, and immorality.

    Science.gov (United States)

    Schirmann, Felix

    2014-01-01

    This article presents a history of the early electroencephalography (EEG) of psychopathy, delinquency, and immorality in Great Britain and the United States in the 1940s and 1950s. Then, EEG was a novel research tool that promised ground-breaking insights in psychiatry and criminology. Experts explored its potential regarding the diagnosis, classification, etiology, and treatment of unethical and unlawful persons. This line of research yielded tentative and inconsistent findings, which the experts attributed to methodological and theoretical shortcomings. Accordingly, the scientific community discussed the reliability, validity, and utility of EEG, and launched initiatives to calibrate and standardize the novel tool. The analysis shows that knowledge production, gauging of the research tool, and attempts to establish credibility for EEG in the study of immoral persons occurred simultaneously. The paper concludes with a reflection on the similarities between EEG and neuroimaging-the prime research tool in the current neuroscience of morality-and calls for a critical assessment of their potentials and limitations in the study of immorality and crime.

  11. The Origin of Dust in the Early Universe: Probing the Star Formation History of Galaxies by Their Dust Content

    Science.gov (United States)

    Dwek, Eli; Cherchneff, Isabelle

    2010-01-01

    Two distinct scenarios for the origin of the approximately 4 x 10(exp 8) Solar Mass of dust observed in the high-redshift (z = 6.4) quasar J1148+5251 have been proposed. The first assumes that this galaxy is much younger than the age of the universe at that epoch so that only supernovae, could have produced this dust. The second scenario assumes a significantly older galactic age, so that the dust could have formed in lower-mass AGB stars. Presenting new integral solutions for the chemical evolution of metals and dust in galaxies, we offer a critical evaluation of these two scenarios. ^N;"(,, show that the AGB scenario is sensitive to the details of the galaxy's star formation history (SFH), which must consist of an early intense starburst followed by a period of low stellar activity. The presence or absence of massive amounts of dust in high-redshift galaxies can therefore be used to infer their SFH. However, a problem with the AGB scenario is that it produces a stellar mass that is significantly larger than the inferred dynamical mass of J1148+5251, an yet unresolved discrepancy. If this problem persists, then additional sites for the growth or formation of dust, such as molecular clouds or dense clouds around active galactic nuclei, must be considered.

  12. ["Lingue di seripi", "serpents' tongues" and "glossopetrae". Highlights from the history of popular "cult" medicine in early modern times].

    Science.gov (United States)

    Freller, T

    1997-01-01

    In the 16th, 17th and 18th century "Glossopetrae", popularly known as "Lingue di Serpi", found on the Mediterranean island of Malta, were extensively used for medical purposes as antidotes. These fossil teeth, including specimens of the "Carcharodon Megalodon" (an extinct variant of the great white shark), were ground to powder or used as amulet pendants and "credence" and exported to pharmacies and shops in various cities of Europe. In antiquity, authors like Plinius or Solinus, excluding any religious connotations, had regarded "Glossopetrae" as objects "fallen from heaven on dark moonless nights". However, from the beginning of the 16th century the miraculous antidotic power of the specimens found at Malta was very strongly connected with the Pauline cult there. This cult owed ist origin to the excerpt of the shipwreck of the Apostle of the Gentiles on this island, as recorded in the New Testament. As in so many cases found in medieval and early modern medicine and pharmacy, the renown, collection, distribution and use of the antidote "Glossopetrae" or "Lingue di Serpi" was never limited to its real chemical and pharmaceutical properties. In the period of enlightenment and secular thinking mythic medicine as "Glossopetrae" had lost ist "magical" power. Consequently, with beginning of the late 18th century also the Maltese "Glossopetrae" featured in literature merely as exotic objects of curiosity or symbols of an age bound to medical superstition.

  13. The vital role of the American Journal of Psychology in the early and continuing history of mental chronometry.

    Science.gov (United States)

    O'Shea, Geoffrey; Bashore, Theodore R

    2012-01-01

    The American Journal of Psychology (AJP) was founded in 1887 by G. Stanley Hall during what Edwin G. Boring (1950) called the Period of Mental Chronometry and, consistent with the prevailing interests of the time, featured articles of relevance to scientists in this research domain. Contained in the early volumes of AJP were several articles that examined what have become some of the enduring issues faced by researchers studying the structure and timing of mental processing using reaction time (RT) procedures. Collectively, RT research published in AJP during its early years contributed to establishing mental chronometry as an important subfield of psychology. From 1900 to 1950 interest in mental chronometry waned, during what has been called its Dark Age. Nonetheless, interest in the effects of factors such as age and intelligence on total RT continued unabated. Numerous articles pertinent to these effects appeared in AJP. Finally, with the publication of Neisser's (1963) seminal work on visual search, AJP played an important role in reviving interest in mental chronometry in the latter half of the 20th century and continues in its 125th year of existence to contribute pertinent articles on contemporary research in mental chronometry.

  14. Triglycerides as an early pathophysiological marker of endothelial dysfunction in nondiabetic women with a previous history of gestational diabetes.

    Science.gov (United States)

    Sokup, Alina; Góralczyk, Barbara; Góralczyk, Krzysztof; Rość, Danuta

    2012-02-01

    To investigate whether baseline triglyceride levels are associated with early glucose dysregulation and/or cardiovascular risk in women with a previous history of gestational diabetes. Prospective postpregnancy cohort study. Polish university hospitals. Participants included 125 women with previous gestational diabetes and 40 women with normal glucose regulation during pregnancy. All women were studied 2-24 months (mean 12 ± 10 months) after the index pregnancy. Women with previous gestational diabetes were divided into tertiles in accordance with baseline triglyceride levels. We assessed glucose regulation (oral glucose tolerance test), insulin resistance (homeostasis model assessment), markers of endothelial dysfunction (soluble: intercellular adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin, tissue plasminogen activator antigen, von Willebrand factor antigen), fibrinolysis (plasminogen activator inhibitor antigen), inflammation (high-sensitivity C-reactive protein) and lipid levels. Women with previous gestational diabetes (78% normal glucose regulation, 22% impaired glucose tolerance) had a high cardiometabolic risk profile compared with control women (100% normal glucose regulation). Baseline triglycerides >0.83 mmol/l were associated with a higher prevalence of impaired glucose tolerance, higher high-sensitivity C-reactive protein and triglyceride/high-density lipoprotein-cholesterol ratio. Triglycerides >1.22 mmol/l were associated with higher body fat indexes, higher insulin resistance, higher levels of endothelial dysfunction biomarkers, higher plasminogen activator inhibitor antigen and dyslipidemia. Only E-selectin was independently associated with triglyceride levels. Baseline triglyceride levels are a cardiovascular risk marker as well as a pathophysiological parameter independently associated with endothelial dysfunction in nondiabetic women with previous gestational diabetes at 2-24 months after an index pregnancy. Normalization of

  15. Challenges of Early Childhood education as a children’s right: analysis of the history and legislation of the 1980’s and 1990’s

    OpenAIRE

    Maria Angélica Olivo Francisco Lucas; Maria Cristina Gomes Machado

    2012-01-01

    This article seeks to analyze the role of Early Childhood education in the period between the end of the Brazilian military dictatorship until the enactment of the current Lei de Diretrizes e Bases da Educação Nacional (National Educational Bases and Guidelines Law – LDB). This period represents a major step in the history of Early Childhood Education due to the development of documents that were essential to the acknowledgment of children’s rights, such as the Constituição Federal (Federal C...

  16. List of subscribers as the source of data on book history and the history of reading: case study of book subscribers' lists printed in Dalmatia in the early 19th century

    Directory of Open Access Journals (Sweden)

    Jelena Lakuš

    2013-02-01

    Full Text Available Customer networks or lists of subscribers as a new publishing phenomenon first occurred in Dalmatia in the early 19th century. It was a model of collective funding of book, magazine and newspaper publishing, which gradually replaced the earlier system of individual patronage. It resulted in the publication of lists of subscribers that contained the names of all those who financially supported the printing of a book. The data on names of subscribers, their occupation, place of residence and number of copies ordered, which was the usual content of subscribers, lists, make them very valuable sources for research on the history of books and reading. This paper tries to show the research potential of such lists by presenting a case-study of five preserved and available subscribers' lists found in publications printed between 1835 and 1848 in the Zadar print shop of Battara brothers. The paper analyses the quantitative data on subscribers, their geographical distribution, professional profile and gender, which does not exhaust their research potential in full. The analysis has shown that despite the austere educational opportunities, high incidence of unemployment, and many other limitations, there were people who treasured the written word. The subscribers mostly came from coastal cities like Zadar, Split and Dubrovnik, which were the most important publishing and cultural centres. Even though the subscribers came from Austria, Military Border, Italy, Croatia proper and Slavonia, as well as Bosnia and Herzegovina, which was then part of the Ottoman Empire, they make up only one eight of the total number of subscribers in the corpus. The subscribers are both Roman-Catholic and Orthodox, who mostly subscribed to books printed in the Cyrillic script. The subscribers come from a wide range of professions, mostly from the church circles in Dalmatia, and the fewest of them were professors and teachers, members of the army and the police. As expected

  17. Human radiation studies: Remembering the early years. Oral history of Biochemist Waldo E. Cohn, Ph.D

    International Nuclear Information System (INIS)

    1995-01-01

    In September 1994, the Department of Energy began an oral history project as part of the Openess initiative on the documentation of the human radiation experiments. This paper presents the oral history of Waldo E Cohn, Ph.D., a Biochemist who worked for the Oak Ridge National Laboratory and the Manhattan Project

  18. Evidence for an agitated-aggressive syndrome in early-onset psychosis correlated with antisocial personality disorder, forensic history, and substance use disorder.

    Science.gov (United States)

    Huber, Christian G; Hochstrasser, Lisa; Meister, Klara; Schimmelmann, Benno G; Lambert, Martin

    2016-08-01

    Agitation, aggression, and violence are increased in psychotic disorders. Additionally, an earlier age at onset may be associated with aggressive behavior. However, the relationship of age at onset, an agitated-aggressive syndrome as measured with the Positive And Negative Syndrome Scale for Schizophrenia - Excited Component (PANSS-EC), and its potential correlates in first-episode psychosis (FEP) has not been studied. This study assessed the association between age at onset, an agitated-aggressive syndrome, and its potential correlates in a prospective sample of 52 FEP patients with early-onset and adult-onset followed up for 12months. Twenty-six patients conformed to the criteria of early-onset psychosis. Early age at onset was associated with antisocial personality disorder (p=0.004; φc=0.39), a history of legal involvement (p=0.005; φc=0.39), and higher rates of lifetime substance use disorder (SUD; p=0.002; φc=0.42). Early-onset patients had significantly higher PANSS-EC scores over the course of observation (F(1,44.4)=5.39; p=0.025; d=0.656), but no significant group differences emerged for the remaining PANSS subscores. PANSS-EC scores were correlated positively with antisocial personality disorder and forensic history at 6weeks, 3months, 6months, and 12months, and with lifetime substance use disorder at 3months and 6months. Patients with early onset psychosis may have increased levels of agitation/aggressiveness, and, more likely, antisocial personality disorder, forensic history, and lifetime substance use disorder. These variables were linked to suicidality, aggressiveness, and involuntary treatment. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. A brief history of the American radium industry and its ties to the scientific community of its early Twentieth Century

    International Nuclear Information System (INIS)

    Landa, E.R.

    1993-01-01

    Federally funded remedial action projects are presently underway in New Jersey and Colorado at sites containing 226 Ra and other radionuclides from radium-uranium ore extraction plants that operated during the early twentieth century. They are but the latest chapter in the story of an American industry that emerged and perished in the span of three decades. Major extraction plants were established in or near Denver (CO), Pittsburgh (PA), and New York City (NY) to process radium from ore that came largely from the carnotite deposits of western Colorado and eastern Utah. The staffs of these plants included some of the finest chemists and physicists in the nation, and the highly-refined radium products found a variety of uses in medicine and industry. The discovery of high-grade pitchblende ores in the Belgian Congo and the subsequent opening of an extraction plant near Antwerp, Belgium, in 1992, however, created an economic climate that put an end to the American radium industry. The geologic, chemical, and engineering information gathered during this era formed the basis of the uranium industry of the later part of the century, while the tailings and residues came to be viewed as environmental problems during the same period

  20. Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

    Directory of Open Access Journals (Sweden)

    Liu Lei

    2008-12-01

    Full Text Available Abstract Background Parkinson's disease, the most common adult neurodegenerative movement disorder, demonstrates a brain-wide pathology that begins pre-clinically with alpha-synuclein aggregates ("Lewy neurites" in processes of gut enteric and vagal motor neurons. Rostral progression into substantia nigra with death of dopamine neurons produces the motor impairment phenotype that yields a clinical diagnosis. The vast majority of Parkinson's disease occurs sporadically, and current models of sporadic Parkinson's disease (sPD can utilize directly infused or systemic neurotoxins. Results We developed a differentiation protocol for human SH-SY5Y neuroblastoma that yielded non-dividing dopaminergic neural cells with long processes that we then exposed to 50 nM rotenone, a complex I inhibitor used in Parkinson's disease models. After 21 days of rotenone, ~60% of cells died. Their processes retracted and accumulated ASYN-(+ and UB-(+ aggregates that blocked organelle transport. Mitochondrial movement velocities were reduced by 8 days of rotenone and continued to decline over time. No cytoplasmic inclusions resembling Lewy bodies were observed. Gene microarray analyses showed that the majority of genes were under-expressed. qPCR analyses of 11 mtDNA-encoded and 10 nDNA-encoded mitochondrial electron transport chain RNAs' relative expressions revealed small increases in mtDNA-encoded genes and lesser regulation of nDNA-encoded ETC genes. Conclusion Subacute rotenone treatment of differentiated SH-SY5Y neuroblastoma cells causes process retraction and partial death over several weeks, slowed mitochondrial movement in processes and appears to reproduce the Lewy neuritic changes of early Parkinson's disease pathology but does not cause Lewy body inclusions. The overall pattern of transcriptional regulation is gene under-expression with minimal regulation of ETC genes in spite of rotenone's being a complex I toxin. This rotenone-SH-SY5Y model in a

  1. Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan.

    Science.gov (United States)

    Belsky, Daniel W; Caspi, Avshalom; Cohen, Harvey J; Kraus, William E; Ramrakha, Sandhya; Poulton, Richie; Moffitt, Terrie E

    2017-08-01

    Therapies to extend healthspan are poised to move from laboratory animal models to human clinical trials. Translation from mouse to human will entail challenges, among them the multifactorial heterogeneity of human aging. To inform clinical trials about this heterogeneity, we report how humans' pace of biological aging relates to personal-history characteristics. Because geroprotective therapies must be delivered by midlife to prevent age-related disease onset, we studied young-adult members of the Dunedin Study 1972-73 birth cohort (n = 954). Cohort members' Pace of Aging was measured as coordinated decline in the integrity of multiple organ systems, by quantifying rate of decline across repeated measurements of 18 biomarkers assayed when cohort members were ages 26, 32, and 38 years. The childhood personal-history characteristics studied were known predictors of age-related disease and mortality, and were measured prospectively during childhood. Personal-history characteristics of familial longevity, childhood social class, adverse childhood experiences, and childhood health, intelligence, and self-control all predicted differences in cohort members' adulthood Pace of Aging. Accumulation of more personal-history risks predicted faster Pace of Aging. Because trials of anti-aging therapies will need to ascertain personal histories retrospectively, we replicated results using cohort members' retrospective personal-history reports made in adulthood. Because many trials recruit participants from clinical settings, we replicated results in the cohort subset who had recent health system contact according to electronic medical records. Quick, inexpensive measures of trial participants' early personal histories can enable clinical trials to study who volunteers for trials, who adheres to treatment, and who responds to anti-aging therapies. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  2. The origins of the plebs Sanctae Agathae. Inscriptions lost and rediscovered on the history of Santhià in the Early Middle Ages

    Directory of Open Access Journals (Sweden)

    Marco Aimone

    2014-04-01

    Full Text Available Two fragments of white marble are embedded in the apsis’ wall outside the parish church of St. Agatha in Santhià (near Vercelli, in Piedmont: the first one is engraved with the final part of a dedicatory inscription to a martyr by a clergyman named Vvalpertus (or Alpertus; the second one is a part of a small pillar or a lintel coming from a presbytery enclosure, and is decorated with a motif of intertwined gallons. The inscription stayed in the middle of a pluteus bordered by a carved frame, of which only a part of the lower band survives: the letters and the style of the decorations allow a chronology within the 8th century, while the fragment of pillar is to be traced back to a period between the 8th and the first half of the 9th. Of special interest are the Lombard onomastic of the dedicator and, in the final surviving text, the “signature” of a sculptor, which is present in a second inscription of Lombard age found in Piedmont, adorned with carved decorations as well. The analysis of these artefacts - hitherto unpublished - offered the opportunity to restudy two other inscriptions once existing in the church of St. Agatha, long lost and of uncertain authenticity: all these data allow various deductions about the history of Santhià over the centuries of the early Middle ages, the presence of a clergy in the countryside of the diocese of Vercelli, and the work of sculptors and engravers active between the 8th and 9th century in an area between Lombardy, Piedmont, Liguria and Provence, labelled in the past under the unifying name of “bottega delle Alpi Marittime”.

  3. Influence of family history of colorectal cancer on health behavior and performance of early detection procedures: the SUN Project.

    Science.gov (United States)

    Martínez-Ochoa, Eva; Gómez-Acebo, Ines; Beunza, Juan-José; Rodríguez-Cundín, Paz; Dierssen-Sotos, Trinidad; Llorca, Javier

    2012-07-01

    The aim of this study is to explore the relationship between family history of colorectal cancer and both health behavior and screening procedures in a population cohort. This study is a cross-sectional analysis of 15,169 participants belonging to a prospective cohort study (the SUN Project) based on two self-reported questionnaires: one of them related to lifestyle and the other a semiquantitative food frequency questionnaire. We explored the influence of family history of colorectal cancer in lifestyles (consumption of alcohol, weight, and diet) and medical management behaviors (screening of chronic diseases). People with family history of colorectal cancer increased their number of colorectal cancer screening tests (adjusted odds ratio for fecal occult blood test: 1.98, 95% confidence interval: 1.48-2.65; and adjusted odds ratio for colonoscopy/sigmoidoscopy: 3.42, 2.69-4.36); nevertheless, health behavior changes in diet of relatives of colorectal cancer patients were undetectable. We show that individuals with a family history of colorectal cancer increase their compliance with screening tests, although they exhibit no better health-related behaviors than people without family history of colorectal cancer. Further prospective studies are required to confirm these results and to identify tools to empower the subjects to change their risk profile. Copyright © 2012 Elsevier Inc. All rights reserved.

  4. Early maladaptive schemas of emotional deprivation, social isolation, shame and abandonment are related to a history of suicide attempts among patients with major depressive disorders.

    Science.gov (United States)

    Ahmadpanah, Mohammad; Astinsadaf, Sommayyeh; Akhondi, Amineh; Haghighi, Mohammad; Sadeghi Bahmani, Dena; Nazaribadie, Marzieh; Jahangard, Leila; Holsboer-Trachsler, Edith; Brand, Serge

    2017-08-01

    Patients with psychiatric disorders have an exceptionally high risk of completed or attempted suicide. This holds particularly true for patients with major depressive disorders. The aim of the present study was to explore whether patients with major depressive disorders (MDD) and a history of suicide attempts differed in their early maladaptive schemas from patients with MDD but without such a history or from healthy controls. Ninety participants took part in the study. Of these, 30 were patients with MDD who had made a recent suicide attempt; 30 were patients with MDD but no suicide attempts, and 30 were gender- and age-matched healthy controls. Participants completed questionnaires covering socio-demographic characteristics and the Young Schema Questionnaire (YSQ- RE2R) to assess early maladaptive schemas. Experts rated patients' MDD with the Montgomery-Asberg Depression Rating Scale. Patients did not differ in experts' ratings of symptoms of depression. Compared to healthy controls, patients with MDD recorded higher scores on maladaptive schemas such as recognition seeking, negativity/pessimism, and insufficient self-control. Compared to patients without suicide attempts and healthy controls, those who had made a suicide attempt had higher scores on dimensions such as failure, mistrust, emotional inhibition, social isolation, and abandonment/instability. Compared to healthy controls, patients with MDD had more pronounced maladaptive schemas, but this was more marked in patients with a history of suicide attempts. The results suggest that suicide attempts and poorer psychological functioning are related. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. The early history (1909-1961) of Epilepsia, the journal of the International League Against Epilepsy, and its echoes today.

    Science.gov (United States)

    Shorvon, Simon

    2007-01-01

    This paper records the history of Epilepsia, the journal of the International League Against Epilepsy, from its inception in 1908/1909 until the beginning of its fourth series in 1961. During this time, publication was interrupted on three occasions and so the journal appeared in four series, with a complex numbering system. Over the years, the content and format of the journal has varied. Its role has changed over the years, at times primarily as a scientific organ and at other times as a source of ILAE news and reports. Concerns throughout its history have included its role as an historical record, its international representation, financial vicissitude, quality of papers, the balance between basic and clinical science, the value of clinical papers, and issues of overspecialization. Epilepsia is today the leading clinical epilepsy journal; but these are still significant concerns, and a knowledge of the history of Epilepsia is important for understanding the current position of the journal.

  6. Inferring the star-formation histories of the most massive and passive early-type galaxies at z < 0.3

    Science.gov (United States)

    Citro, Annalisa; Pozzetti, Lucia; Moresco, Michele; Cimatti, Andrea

    2016-07-01

    Context. In the Λ cold dark matter (ΛCDM) cosmological framework, massive galaxies are the end-points of the hierarchical evolution and are therefore key probes for understanding how the baryonic matter evolves within the dark matter halos. Aims: The aim of this work is to use the archaeological approach in order to infer the stellar population properties and star formation histories of the most massive (M > 1010.75 M⊙) and passive early-type galaxies (ETGs) at 0 tests have been performed to assess the reliability of STARLIGHT to retrieve the evolutionary properties of the ETG stellar populations such as the age, metallicity and star formation history. The results indicate that these properties can be derived with accuracy better than 10% at S/N ≳ 10-20, and also that the procedure of stacking galaxy spectra does not introduce significant biases into their retrieval. Results: Based on our spectral analysis, we found that the ETGs of our sample are very old systems - the most massive ones are almost as old as the Universe. The stellar metallicities are slightly supersolar, with a mean of Z ~ 0.027 ± 0.002 and Z ~ 0.029 ± 0.0015 (depending on the spectral synthesis models used for the fit) and do not depend on redshift. Dust extinction is very low, with a mean of AV ~ 0.08 ± 0.030 mag and AV ~ 0.16 ± 0.048 mag. The ETGs show an anti-hierarchical evolution (downsizing) where more massive galaxies are older. The SFHs can be approximated with a parametric function of the form SFR(t) ∝ τ- (c + 1)tc exp(-t/τ), with typical short e-folding times of τ ~ 0.6-0.8 Gyr (with a dispersion of ±0.1 Gyr) and c ~ 0.1 (with a dispersion of ±0.05). Based on the reconstructed SFHs, most of the stellar mass (≳75%) was assembled by z ~ 5 and ≲4% of it can be ascribed to stellar populations younger than ~1 Gyr. The inferred SFHs are also used to place constraints on the properties and evolution of the ETG progenitors. In particular, the ETGs of our samples should have

  7. Uusi andmeid Mihkli kiriku vanemast ajaloost / New data on the early history of the church of Mihkli

    Directory of Open Access Journals (Sweden)

    Ain Mäesalu

    2012-01-01

    Full Text Available The church of Mihkli is located in Pärnumaa County, approximately 40 km north-west of Pärnu. It is unknown when the limestone building of the church was constructed. The current vaulted church was probably built in the fourth quarter of the 13th century.Preparatory works for building a new roof for the church of Mihkli were carried out in August 2011. The removal of a layer of debris, which had cumulated on top of the vaults of the church, uncovered a layer of soil containing human bones. The results of the archaeological excavations there have led to the assumption that the human bones were brought there in the 19th century together with soil taken from the immediate vicinity of the church, where there used to be a cemetery during the Middle Ages and the Early Modern periodSome of the 55 finds were originally grave goods. A bronze ring, three iron knives, an iron belt-buckle and four silver coins can be considered as such. The artefacts have been dated to the 15th and 16th centuries, whereas the coins were minted in 1515 (?, 1577, 1621 and 1664.The 26 shards of window-glass, some with traces of painting, which were found in the soil, are probably remnants of the church windows. The extraordinary finds were two bronze book clasps that are similar to book clasps used in Northern-Germany and the Netherlands in the 16th century.Three three-ponged sconces produced at the end of the 19th century were found in the holes in the walls located 80–90 cm below the top of the northern and southern walls of the church. The sconces were taken apart and hid in these holes in 1943 during the Second World War.It is now clear, as a result of the excavations that the original stone church had been without vaults, with a simple beam ceiling and plastered from the inside. A two metre long passage within the upper part of the northern wall of the church revealed that it had originally been a fortified church.This paper also discusses if priest Henry, the author

  8. The History of Early Literacy Research and Its Effect on the Project "Enriching a Child's Literacy Environment (ECLE)"

    Science.gov (United States)

    Reid, Ethna R.

    2010-01-01

    By presenting a brief general history of educators' efforts and struggles to influence the intellectual and social growth of young children, it will help the reader understand why the Exemplary Center for Reading Instruction (ECRI), a research and consulting group concerned with instructional practices, sought for and obtained funds from the U.S.…

  9. The Role of the Emperor’s University of Kazan in the History of Formation of Tatar Musical Ethnography (XIX – Early ХХ Century

    Directory of Open Access Journals (Sweden)

    Elmira I. Safiullina

    2014-03-01

    Full Text Available The article reveals the role of the Emperor’s University of Kazan of the XIX-early ХХ century in the history of formation of Tatar musical ethnography. Special attention is paid to activities of scientific organizations at the Emperor’s University of Kazan. Based on the study of manuscripts stored at the Department of Manuscripts and Rare Books at the N.I. Lobachevsky Scientific Library, the article gives information concerning the Asian Musical Magazine by I. Dobrovolsky, as well as the Society for Archeology, History and Ethnography. The author concludes that the Emperor’s University of Kazan has an important role in formation of Tatar musical ethnography.

  10. History and Historians in the Soviet Political and Ideological Structure in 1930s – early 1940s (case study: the Siberian Region

    Directory of Open Access Journals (Sweden)

    Dmitry V. Khaminov

    2014-12-01

    Full Text Available In paper deals with the issues of a place and a role of historical knowledge and historians as a special professional community (university professors, researchers and students of the history departments in the political and ideological structure of the Soviet state in the 1930s – early 1940s. The article restores politics of Communist Party and Soviet government in relation to historians on the example of a unique Siberian small region. The Author made an attempt, on the basis of party and government documents as well as archive materials, some of which were for the first time introduced in scientific circles, give a balanced assessment of these processes in the conditions of the most tragic and controversial periods in the Russian history.

  11. Founding Intentions: A Gender Perspective

    DEFF Research Database (Denmark)

    Scheiner, Ch.; Laspita, S.; Brem, Alexander

    2008-01-01

    In contradiction to previous research, which concentrates almost exclusively onentrepreneurs during their professional activity, this study concentrates on an earlier point in time and that is before the working life begins. Therefore, the micro-social environment (family background) and specific ...... and womenequally.We could also show that the self-employment of the parents does have an influence on the founding intention of the children....

  12. Lost and found: the mincer

    OpenAIRE

    Richards, John

    2008-01-01

    This paper discusses the author’s Mincer: an ‘evolved’ sound generating object of which the mechanical properties and physical material of a meat mincer (grinder) are exploited. Through looking at the Mincer in detail, the author suggests a number of characteristics of the device that reflect current trends within the field of live electronics. This includes working with and appropriating found objects, do-it-yourself (DIY) electronics, bricolage, an emphasis on physical gesture, ...

  13. Decision-Making by Precedent and the Founding of American Honda (1948 - 1974)

    OpenAIRE

    Casadesus-Masanell, Ramon; Heilbron, John Wendell

    2017-01-01

    American Honda was founded in 1959 as a wholly owned subsidiary of the Honda Motor Company to facilitate sales and distribution in the United States. The details of American Honda’s early history have long served as evidence in debates among scholars and practitioners about the managerial determinants of the subsidiary’s success. In particular, it is debated whether American Honda operated according to a deliberate or emergent strategy, i.e. whether or not strategic decisions made in the Stat...

  14. Why and how to measure stock market fluctuations? The early history of stock market indices, with special reference to the French case

    OpenAIRE

    Pierre-Cyrille Hautcoeur

    2006-01-01

    Stock market indices are today a vital and daily tool for both economists and actors in the financial world. The multiplication and the very importance given to these indices raise the question of their accuracy and of the reliability of the methods that are used to construct them. We begin an investigation on these questions by studying the early history of these indices. We show that stock market indices appeared in the daily press in the United States at the end of the 19th century; that a...

  15. The role of church history and Byzantine studies in the history of historical sciences, religious and secular education in Ukraine in the late 19th and early 20th centuries

    Directory of Open Access Journals (Sweden)

    I. Y. Medovkina

    2013-12-01

    Full Text Available The historical retrospective of formation of the non­religious phenomenon «new Christianity» in the conteThe article examines the impact of the educational and scientific activities of famous church historians on the expansion of knowledge in the history of church, development of historical studies, religious and secular education in Ukrainian territories in the late 19th and early 20th centuries. The analysis of the biographies, activities and scientific papers of such well­known scientists as Aleksey Dmitriyevskiy, Ivan Sokolov, Kostiantyn Kharlampovych, Vasyl Bidnov and Oleksandr Lototskyi shows that the scholars made a great contribution to the expansion of historical knowledge in the history of church and Byzantine studies. They achieved it by finding and publishing new sources, studying new topics that had not been covered earlier, applying the historical comparative method and analysing the local history within the context of general history of humankind. Furthermore, just by reviewing the list of offices held by the above scholars, subjects they taught, and scientific journals where they worked as authors and editors and understanding what role they played in preserving church antiques during the period when objects of historical importance were expropriated and used for other purposes, you can appreciate not only their contribution to fostering a great number of well­educated broad­minded and scientifically oriented researchers and clergy members, but also the importance of the position they took on social issues. Because of the social principles they defended the scholars were often persecuted by the Bolsheviks, which caused their premature death or forced emigration.

  16. Early stress, parental motivation, and reproductive decision-making: applications of life history theory to parental behavior.

    Science.gov (United States)

    Cabeza de Baca, Tomás; Ellis, Bruce J

    2017-06-01

    This review focuses on the impact of parental behavior on child development, as interpreted from an evolutionary-developmental perspective. We employ psychosocial acceleration theory to reinterpret the effects of variation in parental investment and involvement on child development, arguing that these effects have been structured by natural selection to match the developing child to current and expected future environments. Over time, an individual's development, physiology, and behavior are organized in a coordinated manner (as instantiated in 'life history strategies') that facilitates survival and reproductive success under different conditions. We review evidence to suggest that parental behavior (1) is strategic and contingent on environmental opportunities and constraints and (2) influences child life history strategies across behavioral, cognitive, and physiological domains. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. The early history of x-ray diagnosis with emphasis on the contributions of physics 1895-1915

    International Nuclear Information System (INIS)

    Mould, R.F.

    1995-01-01

    The contribution of physics to the development of X-ray diagnosis was vital in the early years of this century following Rontgen's discovery 1895-1915. The sections are presented in a logical order beginning with the discovery of X-rays, followed by X-ray tube technology to the advent of the hot cathode Coolidge tube, with the third and final section covering diagnostic radiology physics. It has been compiled from personal research over 35 years in libraries worldwide, drawing on textbooks, journals, popular magazines, newspapers, X-ray company catalogues and museum exhibits. I have included a certain amount of anecdotal information, because after all, much of the early commentaries were indeed anecdotal - and make very interesting reading. Finally it is commented that although this review is devoted to X-ray diagnosis, X-ray therapy should not be forgotten, and readers are referred to another review by the author on early therapeutic advances. (Author)

  18. 'GETTING' THE POX: Reflections by an Historian on How to Write the History of Early Modern Disease.

    Science.gov (United States)

    Stein, Claudia

    This article reflects upon the recent return to linear history writing in medical history. It takes as its starting point a critique of the current return to constructivist ideas, suggesting the use of other methodological choices and interpretations to the surviving archival and textural sources of the sixteenth century pox. My investigation analyses the diagnostic act as an effort to bring together a study of medical semiotics. Medical semiotics considers how signs speak through the physical body, coached within a particular epistemology. There are no hidden meanings behind the visible sign or symptom - it is tranparent to the calculative and authoritative gaze and language of the doctor. It concerns how diseases came into being, the relationships they have constituted, the power they have secured and the actual knowledge/power they have eclipsed or are eclipsing. From such a perspective, "getting the pox" is not a bad thing. A methodological turn to medical semiotics reminds us that the history of disease should be an inquiry both into the grounds of our current knowledge and beliefs about disease and how they inspire our writing, as well as the analytical categories that establish their inevitability.

  19. ‘Getting’ the Pox: Reflections by an Historian on How to Write the History of Early Modern Disease

    Directory of Open Access Journals (Sweden)

    Claudia Stein

    2014-06-01

    Full Text Available This article reflects upon the recent return to linear history writing in medical history. It takes as its starting point a critique of the current return to constructivist ideas, suggesting the use of other methodological choices and interpretations to the surviving archival and textural sources of the sixteenth century pox. My investigation analyses the diagnostic act as an effort to bring together a study of medical semiotics. Medical semiotics considers how signs speak through the physical body, coached within a particular epistemology. There are no hidden meanings behind the visible sign or symptom - it is tranparent to the calculative and authoritative gaze and language of the doctor. It concerns how diseases came into being, the relationships they have constituted, the power they have secured and the actual knowledge/power they have eclipsed or are eclipsing. From such a perspective, “getting the pox” is not a bad thing. A methodological turn to medical semiotics reminds us that the history of disease should be an inquiry both into the grounds of our current knowledge and beliefs about disease and how they inspire our writing, as well as the analytical categories that establish their inevitability.

  20. New Plants at Prague Castle and Hradčany in the Early Modern Period. A History of Selected Species

    Czech Academy of Sciences Publication Activity Database

    Beneš, J.; Čulíková, Věra; Kosňovská, J.; Frolík, Jan; Matiášek, Josef

    2012-01-01

    Roč. 3, č. 1 (2012), s. 103-114 ISSN 1804-848X Institutional research plan: CEZ:AV0Z80020508 Keywords : Prague Castle * Early Modern Period * archaeobotany Subject RIV: AC - Archeology, Anthropology, Ethnology http://www.iansa.eu/papers/IANSA-2012-01-benes.pdf

  1. IQ at Age 12 Following a History of Institutional Care: Findings from the Bucharest Early Intervention Project

    Science.gov (United States)

    Almas, Alisa N.; Degnan, Kathryn A.; Nelson, Charles A.; Zeanah, Charles H.; Fox, Nathan A.

    2016-01-01

    Young children removed from institutions and placed into foster care or adoptive homes have been shown to experience significant gains in IQ relative to children who remain in institutions. Less is known about the long-term impact of severe early deprivation on development in late childhood. Data are presented from a follow-up of children at 12…

  2. The ATLAS3D Project - XXX. Star formation histories and stellar population scaling relations of early-type galaxies

    NARCIS (Netherlands)

    McDermid, Richard M.; Alatalo, Katherine; Blitz, Leo; Bournaud, Frédéric; Bureau, Martin; Cappellari, Michele; Crocker, Alison F.; Davies, Roger L.; Davis, Timothy A.; de Zeeuw, P. T.; Duc, Pierre-Alain; Emsellem, Eric; Khochfar, Sadegh; Krajnović, Davor; Kuntschner, Harald; Morganti, Raffaella; Naab, Thorsten; Oosterloo, Tom; Sarzi, Marc; Scott, Nicholas; Serra, Paolo; Weijmans, Anne-Marie; Young, Lisa M.

    We present the stellar population content of early-type galaxies from the ATLAS3D survey. Using spectra integrated within apertures covering up to one effective radius, we apply two methods: one based on measuring line-strength indices and applying single stellar population (SSP) models to derive

  3. Understanding Factors Associated with Early Therapeutic Alliance in PTSD Treatment: Adherence, Childhood Sexual Abuse History, and Social Support

    Science.gov (United States)

    Keller, Stephanie M.; Zoellner, Lori A.; Feeny, Norah C.

    2010-01-01

    Objective: Therapeutic alliance has been associated with better treatment engagement, better adherence, and less dropout across various treatments and disorders. In treatment of posttraumatic stress disorder (PTSD), it may be particularly important to establish a strong early alliance to facilitate treatment adherence. However, factors such as…

  4. How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD.

    Science.gov (United States)

    Needham, Patrick G; Brodsky, Jeffrey L

    2013-11-01

    All newly synthesized proteins are subject to quality control check-points, which prevent aberrant polypeptides from harming the cell. For proteins that ultimately reside in the cytoplasm, components that also reside in the cytoplasm were known for many years to mediate quality control. Early biochemical and genetic data indicated that misfolded proteins were selected by molecular chaperones and then targeted to the proteasome (in eukaryotes) or to proteasome-like particles (in bacteria) for degradation. What was less clear was how secreted and integral membrane proteins, which in eukaryotes enter the endoplasmic reticulum (ER), were subject to quality control decisions. In this review, we highlight early studies that ultimately led to the discovery that secreted and integral membrane proteins also utilize several components that constitute the cytoplasmic quality control machinery. This component of the cellular quality control pathway is known as ER associated degradation, or ERAD. This article is part of a Special Issue entitled: Functional and structural diversity of endoplasmic reticulum. Copyright © 2013 Elsevier B.V. All rights reserved.

  5. The Hidden History of a Famous Drug: Tracing the Medical and Public Acculturation of Peruvian Bark in Early Modern Western Europe (c. 1650-1720).

    Science.gov (United States)

    Klein, Wouter; Pieters, Toine

    2016-10-01

    The history of the introduction of exotic therapeutic drugs in early modern Europe is usually rife with legend and obscurity and Peruvian bark is a case in point. The famous antimalarial drug entered the European medical market around 1640, yet it took decades before the bark was firmly established in pharmaceutical practice. This article argues that the history of Peruvian bark can only be understood as the interplay of its trajectories in science, commerce, and society. Modern research has mostly focused on the first of these, largely due to the abundance of medico-historical data. While appreciating these findings, this article proposes to integrate the medical trajectory in a richer narrative, by drawing particular attention to the acculturation of the bark in commerce and society. Although the evidence we have for these two trajectories is still sketchy and disproportionate, it can nevertheless help us to make sense of sources that have not yet been an obvious focus of research. Starting from an apparently isolated occurrence of the drug in a letter, this article focuses on Paris as the location where medical and public appreciation of the bark took shape, by exploring several contexts of knowledge circulation and medical practice there. These contexts provide a new window on the early circulation of knowledge of the bark, at a time when its eventual acceptance was by no means certain. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. Risk factors for alcoholism in the Oklahoma Family Health Patterns project: impact of early life adversity and family history on affect regulation and personality.

    Science.gov (United States)

    Sorocco, Kristen H; Carnes, Nathan C; Cohoon, Andrew J; Vincent, Andrea S; Lovallo, William R

    2015-05-01

    This study examined the impact of early lifetime adversity (ELA) on affect regulation and personality in persons with family history (FH+) and without (FH-) a family history of alcoholism. We examined the impact of early life adversity in healthy young adults, 18-30 years of age enrolled in a long-term study on risk for alcohol and other substance abuse. ELA was assessed by a composite score of low socioeconomic status and personal experience of physical or sexual abuse and/or separation from parents before age 16, resulting in a score of 0, 1-2, or >3 adverse events. Unstable affect regulation and personality variables were obtained via self-report measures. Higher ELA scores were seen in FH+ (χ(2)=109.2, paffect regulation, negative moods, and have risky drinking and drug abuse tendencies independent of ELA level. ELA predicts reduced stress reactivity and poorer cognitive control over impulsive behaviors as shown elsewhere. The present work shows that FH+ have poor mood regulation and antisocial characteristics. The greater prevalence of ELA in FH+ persons indicates that life experience and FH+ work in tandem to result in risky patterns of alcohol and drug experimentation to elevate risk for alcoholism. Further studies of genetic and environmental contributions to alcoholism are called for. Published by Elsevier Ireland Ltd.

  7. THE CHALLENGES OF INSTITUTIONALIZATION AND IMPLEMENTATION OF HISTORY-CRITICAL PEDAGOGY IN EARLY YEARS OF BASIC EDUCATION ITAIPULÂNDIA-PR

    Directory of Open Access Journals (Sweden)

    Celso Sidinei Balzan

    2013-12-01

    Full Text Available This paper is situated within the history of education and its purpose is to investigate the challenges of institutionalization of historical-critical pedagogy (PHC at the early elementary school years in municipal network Itaipulândia-PR. In it, we try to analyze briefly articulated with the proposals and actions carried out over several years, especially in 2010 itaipulandiense educational trajectory. These achievements currently make up the municipal public education policy that includes training programs that articulate with better working conditions, teaching and learning. Based on documents and literature review, discuss and seek to understand how the teachers of this county propositions developed from the study of the major challenges that the historical-critical pedagogy faces in Brazilian education, using experiences, educational programs and projects of State Governments and federal. In addressing the specific conditions that focus on education, the school and the organization of the teaching work through the analysis of its historical and educational history, we intend to analyze the process of institutionalization and implementation of this pedagogical trend in the early years of basic education in the municipality of Itaipulândia.

  8. The anthropometric history of Argentina, Brazil and Peru during the 19th and early 20th century.

    Science.gov (United States)

    Baten, Joerg; Pelger, Ines; Twrdek, Linda

    2009-12-01

    This anthropometric study focuses on the histories of three important Latin American countries - Brazil, Peru, and Argentina - during the 19th century, and tests hypotheses concerning their welfare trends. While non-farm Brazil and Lima, Peru, started at relatively low height levels, Brazil made substantial progress in nutritional levels from the 1860s to the 1880s. In contrast, Lima remained at low levels. Argentinean men were tall to begin with, but heights stagnated until 1910. The only exception were farmers and landowners, who benefited from the export boom.

  9. Does early use of enzyme replacement therapy alter the natural history of mucopolysaccharidosis I? Experience in three siblings.

    Science.gov (United States)

    Laraway, Sarah; Breen, Catherine; Mercer, Jean; Jones, Simon; Wraith, James E

    2013-07-01

    Enzyme replacement therapy is widely used as treatment for mucopolysaccharidosis I (MPS I), and there is evidence that this produces improvement in certain clinical domains. There does appear to be variation in the response of clinical features to treatment once these are established. In a reported sibling pair, when enzyme replacement therapy was commenced pre-symptomatically in the younger child, the natural history of the condition appeared to be affected. We present data from three siblings treated with enzyme replacement therapy at different ages which supports this finding. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

  11. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    International Nuclear Information System (INIS)

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz's research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments

  12. Lightweight Double Neutron Star Found

    Science.gov (United States)

    Kohler, Susanna

    2018-02-01

    More than forty years after the first discovery of a double neutron star, we still havent found many others but a new survey is working to change that.The Hunt for PairsThe observed shift in the Hulse-Taylor binarys orbital period over time as it loses energy to gravitational-wave emission. [Weisberg Taylor, 2004]In 1974, Russell Hulse and Joseph Taylor discovered the first double neutron star: two compact objects locked in a close orbit about each other. Hulse and Taylors measurements of this binarys decaying orbit over subsequent years led to a Nobel prize and the first clear evidence of gravitational waves carrying energy and angular momentum away from massive binaries.Forty years later, we have since confirmed the existence of gravitational waves directly with the Laser Interferometer Gravitational-Wave Observatory (LIGO). Nonetheless, finding and studying pre-merger neutron-star binaries remains a top priority. Observing such systems before they merge reveals crucial information about late-stage stellar evolution, binary interactions, and the types of gravitational-wave signals we expect to find with current and future observatories.Since the Hulse-Taylor binary, weve found a total of 16 additional double neutron-star systems which represents only a tiny fraction of the more than 2,600 pulsars currently known. Recently, however, a large number of pulsar surveys are turning their eyes toward the sky, with a focus on finding more double neutron stars and at least one of them has had success.The pulse profile for PSR J1411+2551 at 327 MHz. [Martinez et al. 2017]A Low-Mass DoubleConducted with the 1,000-foot Arecibo radio telescope in Puerto Rico, the Arecibo 327 MHz Drift Pulsar Survey has enabled the recent discovery of dozens of pulsars and transients. Among them, as reported by Jose Martinez (Max Planck Institute for Radio Astronomy) and coauthors in a recent publication, is PSR J1411+2551: a new double neutron star with one of the lowest masses ever measured

  13. Human radiation studies: Remembering the early years: Oral history of pathologist Clarence Lushbaugh, M.D., conducted October 5, 1994

    International Nuclear Information System (INIS)

    1995-04-01

    This report provides a transcript of an interview with Dr. Clarance Lushbaugh by representatives of the DOE Office of Human Radiation Experiments. Dr. Lushbaugh was chosen for this interview because of his research involving experimental use of irradiation with human beings at Los Alamos and at the Oak Ridge Institute of Nuclear Science (ORINS). After a brief biographical sketch Dr. Lushbaugh and his assistant Mrs. Ann Swipe defend their use of total body irradiation using the LETBI (Low Exposure Total Body Irradiation) and the LETBI (Medium Energy Total Body Irradiator). Dr. Lushbaugh also discusses his earlier experiments involving use of nitrogen mustards in chemotherapy application, his early interest in the LD50 for man, his early impressions of low-level spray radiation as introduced by Heubline, anedotal information for his duties a pathologist for Los Alamos, and his developing interest in establishing safer radiation limits for human exposure

  14. On some additional recollections, and the absence thereof, about the early history of computer simulations in statistical mechanics

    International Nuclear Information System (INIS)

    Wood, W.W.

    1995-01-01

    This lecture is an extension and correction of a previous lecture given by the author ten years ago at ''Corso 97'' in Varenna. Here again he emphasizes that his early work was exclusively with applications of the Metropolis Monte Carlo method. His only connection with the early work on the molecular dynamics method was in collaboration with Alder and Wainwright in their joint effort to reconcile the results of the Monte Carlo and molecular dynamics methods for hard spheres. Here he amplifies a point suggested by a question asked by Professor Ciccotti: Namely, when was it discovered that the Metropolis method consists in the generation of a realization of a Markov chain, for which there was a large body of mathematical theory that made the justification of the method quite a simple matter?

  15. Does history of childhood maltreatment make a difference in prison? A hierarchical approach on early family events and personality traits.

    Science.gov (United States)

    Sergentanis, Theodoros N; Sakelliadis, Emmanouil I; Vlachodimitropoulos, Dimitrios; Goutas, Nikolaos; Sergentanis, Ioannis N; Spiliopoulou, Chara A; Papadodima, StavroulaA

    2014-12-30

    This study attempts to assess childhood maltreatment in prison through a hierarchical approach. The hierarchical approach principally aims to disentangle the independent effects of childhood maltreatment upon psychiatric morbidity/personality traits, if any, from the burden that the adverse family conditions have already imposed to the mental health of the maltreated individual-prisoner. To this direction, a conceptual framework with five hierarchical levels was constructed, namely: immutable demographic factors; family conditions; childhood maltreatment (physical abuse, neglect and sexual abuse); personality traits, habits and psychiatric morbidity; prison-related variables. A self-administered, anonymous set (battery) of questionnaires was administered to 173 male prisoners in the Chalkida prison, Greece; 26% of prisoners disclosed childhood maltreatment. Psychiatric condition in the family, parental alcoholism and parental divorce correlated with childhood maltreatment. After adjustment for immutable demographic factors and family conditions, childhood maltreatment was associated with aggression (both in terms of Lifetime History of Aggression and Buss–Perry Aggression Questionnaire scores), illicit substance use, personal history of psychiatric condition, current smoking, impulsivity and alcohol abuse. In conclusion, childhood maltreatment represents a pivotal, determining factor in the life course of male prisoners. Delinquents seem to suffer from long-term consequences of childhood maltreatment in terms of numerous mental health aspects.

  16. Maternal History and Uterine Artery Doppler in the Assessment of Risk for Development of Early- and Late-Onset Preeclampsia and Intrauterine Growth Restriction

    Directory of Open Access Journals (Sweden)

    Elisa Llurba

    2009-01-01

    Full Text Available Objective. To examine the value of one-step uterine artery Doppler at 20 weeks of gestation in the prediction pre-eclampsia (PE and/or intrauterine growth restriction (IUGR. Methods. A prospective multicentre study that included all women with singleton pregnancies at 19–22 weeks of gestation (w. The mean pulsatility index (mPI of both uterine arteries was calculated. Receiver-operating characteristics curves (ROC were drawn to compare uterine artery Doppler and maternal risk factors for the prediction of early-onset PE and/or IUGR (before 32 w and late-onset PE and/or IUGR. Results. 6,586 women were included in the study. Complete outcome data was recorded for 6,035 of these women (91.6%. PE developed in 75 (1.2% and IUGR in 69 (1.1% cases. Uterine Doppler mPI was 0.99 and the 90th centile was 1.40. For 10% false-positive rate, uterine Doppler mPI identified 70.6% of pregnancies that subsequently developed early-onset PE and 73.3% of pregnancies that developed early-onset IUGR. The test had a lower detection rate for the late-onset forms of the disease (23.5% for PE and 30% for IUGR. Maternal history has a low sensitivity in the detection of early-onset cases, although it is better at detecting late-onset PE. Conclusion. Uterine artery Doppler and maternal risk factors seem to select two different populations - early and late-onset PE which might suggest a different pathogenesis.

  17. Natural history of bleeding and characteristics of early bleeders among warfarin initiators – a cohort study in Finland

    Directory of Open Access Journals (Sweden)

    Rikala M

    2016-02-01

    Full Text Available Maria Rikala,1 Helena Kastarinen,1,2 Pekka Tiittanen,1 Risto Huupponen,1,3 Maarit Jaana Korhonen1,4,5 1Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 2Social Insurance Institution, Regional Office for Eastern and Northern Finland, Kuopio, 3Unit of Clinical Pharmacology, Turku University Hospital, 4Department of Public Health, University of Turku, Turku, Finland; 5Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, NC, USA Aims: The demand for oral anticoagulant therapy will continue to increase in the future along with the aging of the population. This study aimed to determine the rate of bleeding requiring hospitalization and to characterize early bleeders among persons initiating warfarin therapy. Characterization of those most susceptible to early bleeding is important in order to increase the safety of warfarin initiation. Patients and methods: Using data from nationwide health registers, we identified persons initiating warfarin therapy between January 1, 2009 and June 30, 2012, n=101,588, and followed them until hospitalization for bleeding, death, or administrative end of the study (December 31, 2012. We defined early bleeders as persons with a bleeding requiring hospitalization within 30 days since warfarin initiation. Results: The rate of hospitalization for bleeding during a median follow-up of 1.9 years was 2.6% per person-year (95% confidence interval [CI] 2.5%–2.7%, with a peak within the first 30 days of warfarin initiation (6.5% per person-year, 95% CI 6.0%–7.1%. In a multivariable Cox proportional hazards regression analysis, early bleeders were characterized by prior bleeding (<180 days before initiation, hazard ratio [HR] =13.7, 95% CI 10.9–17.1; during 180 days–7 years before initiation, HR =1.48, 95% CI 1.15–1.90, male sex (HR =1.32, 95% CI 1.10–1.57, older age (HR =1.13, 95% CI 1.04–1

  18. The early history of x-ray diagnosis with emphasis on the contributions of physics 1895-1915.

    Science.gov (United States)

    Mould, R F

    1995-11-01

    The contribution of physics to the development of x-ray diagnosis was vital in the early years of this century following Röntgen's discovery of x-rays in November 1895. This review records some of the highlights during the period 1895-1915. Much of the information presented has been buried in libraries for more than 50 years and the selection of illustrations and text will be largely unknown to today's readership of Physics in Medicine and Biology. It is also a celebration of what could be achieved in physics before the occurrence of the technological revolution involving not only computer applications but also the disappearance of the small independent x-ray companies into today's multinational companies. Research and development is nowadays just too expensive for much independent practical high-technology contributions without financial backing. Hence this review takes us to those bygone years of experimental physics in home laboratories, poorly equipped university physics laboratories and of the lecture-demonstrations of the period. The sections are presented in a logical order beginning with the discovery of x-rays, followed by x-ray tube technology to the advent of the hot cathode Coolidge tube, with the third and final section covering diagnostic radiology physics. It has been compiled from personal research over 35 years in libraries worldwide, drawing on textbooks, journals, popular magazines, newspapers, x-ray company catalogues and museum exhibits. I have included a certain amount of anecdotal information, because after all, much of the early commentaries were indeed anecdotal--and make very interesting reading. Finally it is commented that although this review is devoted to x-ray diagnosis, x-ray therapy should not be forgotten, and readers are referred to another review by the author on early therapeutic advances.

  19. Challenges of Early Childhood education as a children’s right: analysis of the history and legislation of the 1980’s and 1990’s

    Directory of Open Access Journals (Sweden)

    Maria Angélica Olivo Francisco Lucas

    2012-06-01

    Full Text Available This article seeks to analyze the role of Early Childhood education in the period between the end of the Brazilian military dictatorship until the enactment of the current Lei de Diretrizes e Bases da Educação Nacional (National Educational Bases and Guidelines Law – LDB. This period represents a major step in the history of Early Childhood Education due to the development of documents that were essential to the acknowledgment of children’s rights, such as the Constituição Federal (Federal Constitution – 1988, the Estatuto da Criança e do Adolescente (Child and Adolescent Statute – ECA (1990 and the Política Nacional de Educação Infantil (National Policy for Early Childhood Education – PNEI (1994. All of these documents were used as basis for this study. The constitutional text recognized children as citizens, while the ECA has strengthened this commitment from the part of the State. Similarly, the PNEI has defi ned the suitable conditions for children’s overall development. However, the universal implementation of a quality service progresses slowly, since the specifi city of this educational modality is yet to be fully recognized.

  20. Redox history of the Three Gorges region during the Ediacaran and Early Cambrian as indicated by the Fe isotope

    Directory of Open Access Journals (Sweden)

    Yusuke Sawaki

    2018-01-01

    To circumvent this deficiency, we drilled a fossiliferous Ediacaran to Early Cambrian sedimentary succession in the Three Gorges region, South China. We analyzed the iron isotope ratios (δ56/54Fe of pyrite grains in the drill cores using laser ablation multi collector inductively coupled plasma mass spectrometry. The results demonstrate large variations in δ56/54Fe, from −1.6 to 1.6‰, and positive iron isotope ratios are observed in many successions. The presence of positive δ56/54Fe in pyrite indicates that the ferrous iron in the seawater was partially oxidized, suggesting that seawater at Three Gorges was ferruginous during the Ediacaran and Early Cambrian periods. However, aggregated pyrite grains in organic carbon-rich black shales at Member 4 of the Doushantuo Formation and the base of the Shuijingtuo Formation yield near-zero δ56/54Fe values; this suggests that the ocean was transiently dominated by sulfidic conditions during these periods. Notably negative δ56/54Fe values, lower than −1‰, can be interpreted as a signature of DIR. The DIR also might contribute in part to the re-mineralization of organic matter during the largest negative carbon isotope anomaly in the Ediacaran.

  1. Early-Modern Irreligion and Theological Analogy: A Response to Gavin Hyman’s A Short History of Atheism

    Directory of Open Access Journals (Sweden)

    Daniel J Linford

    2016-01-01

    Full Text Available Historically, many Christians have understood God’s transcendence to imply God’s properties categorically differ from any created properties. For multiple historical figures, a problem arose for religious language: how can one talk of God at all if none of our predicates apply to God? What are we to make of creeds and Biblical passages that seem to predicate creaturely properties, such as goodness and wisdom, of God? Thomas Aquinas offered a solution: God is to be spoken of only through analogy (the doctrine of analogy. Gavin Hyman argues Aquinas’s doctrine of analogy was neglected prior to the early-modern period and the neglect of analogy produced the conception of a god vulnerable to atheistic arguments. Contra Hyman, in this paper, I show early-modern atheism arose in a theological context in which there was an active debate concerning analogy. Peter Browne (1665–1735 and William King (1650–1729 offered two competing conceptions of analogical predication that were debated through the 19th century, with interlocutors such as the freethinker Anthony Collins (1676–1729, theologian/philosopher George Berkeley (1685–1753, and skeptic David Hume (1711–1776. Lastly, I discuss the 18th century debate over theological analogy as part of the background relevant to understanding Hume’s 'Dialogues Concerning Natural Religion'.

  2. Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone.

    LENUS (Irish Health Repository)

    Mak, George J

    2012-02-01

    OBJECTIVES: This study was designed to evaluate the impact of eplerenone on collagen turnover in preserved systolic function heart failure (HFPSF). BACKGROUND: Despite growing interest in abnormal collagen metabolism as a feature of HFPSF with diastolic dysfunction, the natural history of markers of collagen turnover and the impact of selective aldosterone antagonism on this natural history remains unknown. METHODS: We evaluated 44 patients with HFPSF, randomly assigned to control (n = 20) or eplerenone 25 mg daily (n = 24) for 6 months, increased to 50 mg daily from 6 to 12 months. Serum markers of collagen turnover and inflammation were analyzed at baseline and at 6 and 12 months and included pro-collagen type-I and -III aminoterminal peptides, matrix metalloproteinase type-2, interleukin-6 and -8, and tumor necrosis factor-alpha. Doppler-echocardiographic assessment of diastolic filling indexes and tissue Doppler analyses were also obtained. RESULTS: The mean age of the patients was 80 +\\/- 7.8 years; 46% were male; 64% were receiving an angiotensin-converting enzyme inhibitor, 34% an angiotensin-II receptor blocker, and 68% were receiving beta-blocker therapy. Pro-collagen type-III and -I aminoterminal peptides, matrix metalloproteinase type-2, interleukin-6 and -8, and tumor necrosis factor-alpha increased with time in the control group. Eplerenone treatment had no significant impact on any biomarker at 6 months but attenuated the increase in pro-collagen type-III aminoterminal peptide at 12 months (p = 0.006). Eplerenone therapy was associated with modest effects on diastolic function without any impact on clinical variables or brain natriuretic peptide. CONCLUSIONS: This study demonstrates progressive increases in markers of collagen turnover and inflammation in HFPSF with diastolic dysfunction. Despite high background utilization of renin-angiotensin-aldosterone modulators, eplerenone therapy prevents a progressive increase in pro-collagen type

  3. Disturbance of recruitment success of mantis shrimp in Tokyo Bay associated with effects of hypoxia on the early life history.

    Science.gov (United States)

    Kodama, Keita; Tajima, Yoshihiro; Shimizu, Takamichi; Ohata, Satoshi; Shiraishi, Hiroaki; Horiguchi, Toshihiro

    2014-08-30

    We investigated effects of severe hypoxia (dissolved oxygen shrimp Oratosquilla oratoria in Tokyo Bay. Ten-year field surveys were conducted to examine quantitative relationships in annual mean densities of larvae and juveniles, and spatial distribution of juveniles and severe hypoxia. There was no significant correlation between annual mean densities of larvae and juveniles, suggesting that mortality during larval or juvenile stages varies among years, which might have regulated abundance of young-of-the-year juveniles. Juvenile density was low in the severely hypoxic area, implying that hypoxia could affect survivals and spatial distribution of juveniles. Meanwhile, there are yearly fluctuations in juvenile density in normoxic areas of both northern and southern part of the bay. This evidence suggests that abundance of post-settled juveniles might have been determined by not only effects of hypoxia, but also other factors influencing mortality during the early life stages. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Human radiation studies: Remembering the early years. Oral history of biochemist John Randolph Totter, Ph.D., January 23, 1995

    International Nuclear Information System (INIS)

    1995-09-01

    This document is a transcript of an interview of Dr. John Randolph Tottler by representatives of the US DOE Office of Human Radiation Experiments. Dr. Tottler was selected for this interview because of his career with the Atomic Energy Commission Division of Biology and Medicine (DBM), particularly as its director from 1967 to 1972. After a short biographical sketch Dr. Tottler discusses his remembrances on a wide range topics including nucleic acid and leukemia research at Oak Ridge, AEC biochemistry training in South America, DBM's research focus on radiation effects, early leadership of DBM, relations with the US Public Health Service, controversies on low-level radiation, iodine from fallout, on John Gofman, and Project Plowshare, funding for AEC Research Programs and for international research, testicular irradiation of prisoners in Washington State and Oregon, Plutonium injections, ethics of government radiation research, and opinions of public misperceptions about radiation and cancer

  5. Paleomagnetic determinations on Lanzarote from magnetic and gravity anomalies: Implications for the early history of the Canary Islands

    Science.gov (United States)

    Blanco-Montenegro, I.; Montesinos, F. G.; GarcíA, A.; Vieira, R.; VillalaíN, J. J.

    2005-12-01

    The Bouguer and aeromagnetic anomaly maps of Lanzarote show a gravity high and a dipolar magnetic anomaly over the central part of the island, indicating one isolated source. Assuming that the structure responsible for both anomalies is the same, a methodology has been designed to estimate the total magnetization vector of the source, which is interpreted as a large intrusive body (mafic core) positioned as a result of magma rising to the surface during the early stages of growth of Lanzarote. Considering its geometry to be known from a previous three-dimensional (3-D) gravity model, the approach proposed in this paper is based on the delineation of magnetic contacts through analysis of the horizontal gradient of the reduced-to-the-pole anomaly map, comparison between the gravity and the pseudogravity anomalies, and 3-D forward magnetic modeling. The total magnetization vector obtained by this method is defined by a module of 4.5 A m-1 and a direction D = -20° and I = 30°. Comparing the paleomagnetic pole, obtained from this direction, with the apparent polar wander path of Africa for the last 160 Myr, it is concluded that the main component of the total magnetization vector is probably a primary natural remanent magnetization (NRM) which could have been acquired between 60 and 100 Ma. This result suggests that the emplacement of magmas at shallow depths linked to the beginning of volcanism in Lanzarote took place during the Upper Cretaceous, thus providing the first evidence of a timeline for the early formative stages of this volcanic island.

  6. Spelling impairments in Italian dyslexic children with and without a history of early language delay. Are there any differences?

    Directory of Open Access Journals (Sweden)

    Paola eAngelelli

    2016-04-01

    Full Text Available Language delay is considered a frequent antecedent of literacy problems and both may be linked to phonological impairment. However, while several studies have examined the relationship between language delay and reading impairment, relatively few have focused on spelling.In this study, spelling performance of 28 children with developmental dyslexia (DD, 14 children with a history of language delay (LD and 14 children without (NoLD and 28 control participants were examined.Spelling was investigated by writing a dictation task that included orthographically regular stimuli (word and nonwords, as well as words with unpredictable transcription.Results indicated that all dyslexic participants underperformed compared to controls on both regular and unpredictable transcription stimuli, but LD performance was generally the worst. Moreover, spelling impairment assumed different characteristics in LD and NoLD children. LD children were more sensitive to acoustic-to-phonological variables, showing relevant failure especially on stimuli containing geminate consonants but also on polysyllabic stimuli and those containing non-continuant consonants. Error analysis confirmed these results, with LD children producing a higher rate of phonological errors respect to NoLD children and controls. Results were coherent with the hypothesis that among dyslexic children, those with previous language delay have more severe spelling deficit, suffering from defective orthographic lexical acquisition together with long-lasting phonological difficulties.

  7. Spelling Impairments in Italian Dyslexic Children with and without a History of Early Language Delay. Are There Any Differences?

    Science.gov (United States)

    Angelelli, Paola; Marinelli, Chiara V; Iaia, Marika; Putzolu, Anna; Gasperini, Filippo; Brizzolara, Daniela; Chilosi, Anna M

    2016-01-01

    Language delay is considered a frequent antecedent of literacy problems and both may be linked to phonological impairment. However, while several studies have examined the relationship between language delay and reading impairment, relatively few have focused on spelling. In this study, spelling performance of 28 children with developmental dyslexia (DD), 14 children with a history of language delay (LD), and 14 children without (NoLD) and 28 control participants were examined. Spelling was investigated by a writing to dictation task that included orthographically regular stimuli (word and non-words), as well as words with unpredictable transcription. Results indicated that all dyslexic participants underperformed compared to controls on both regular and unpredictable transcription stimuli, but LD performance was generally the worst. Moreover, spelling impairment assumed different characteristics in LD and NoLD children. LD children were more sensitive to acoustic-to-phonological variables, showing relevant failure especially on stimuli containing geminate consonants but also on polysyllabic stimuli and those containing non-continuant consonants. Error analysis confirmed these results, with LD children producing a higher rate of phonological errors respect to NoLD children and controls. Results were coherent with the hypothesis that among dyslexic children, those with previous language delay have more severe spelling deficit, suffering from defective orthographic lexical acquisition together with long-lasting phonological difficulties.

  8. Early days in complex dynamics a history of complex dynamics in one variable during 1906-1942

    CERN Document Server

    Alexander, Daniel S; Rosa, Alessandro

    2011-01-01

    The theory of complex dynamics, whose roots lie in 19th-century studies of the iteration of complex function conducted by Kœnigs, Schröder, and others, flourished remarkably during the first half of the 20th century, when many of the central ideas and techniques of the subject developed. This book by Alexander, Iavernaro, and Rosa paints a robust picture of the field of complex dynamics between 1906 and 1942 through detailed discussions of the work of Fatou, Julia, Siegel, and several others. A recurrent theme of the authors' treatment is the center problem in complex dynamics. They present its complete history during this period and, in so doing, bring out analogies between complex dynamics and the study of differential equations, in particular, the problem of stability in Hamiltonian systems. Among these analogies are the use of iteration and problems involving small divisors which the authors examine in the work of Poincaré and others, linking them to complex dynamics, principally via the work of Samuel...

  9. Columbia River White Sturgeon (Acipenser Transmontanus) Early Life History and Genertics Study, August 1, 1984 to December 31, 1985 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Brannon, Ernest L.

    1985-12-01

    Research on Columbia River white sturgeon has been directed at their early life history as it may apply to production and enhancement strategies for management of the species. The river environment in which sturgeon historically migrated, spawned, and reared has changed through development. Habitat changes are expected to precipitate genetic changes in the fish, as well as reduce the fitness in populations. Genetic analysis of samples taken from various locations over the length of the Columbia River have indicated that observed gene frequencies in all areas sampled were not in Hardy-Weinburg equilibrium, which could suggest that the general population is experiencing perturbation in the system. Analysis thus far has exposed few differences between samples from the lower, middle, and upper portions of the system. Allelic differences were identified in fish from the Roosevelt Lake, which may be evidence of unique characteristics among fish from that general area.

  10. War and hunting poisons of the New World. Part 1. Notes on the early history of curare.

    Science.gov (United States)

    Bisset, N G

    1992-02-01

    The history to about 1850 of the muscle-relaxant poison curare is discussed, especially the developments leading to the botanical identification of the plants that yield the alkaloidal active principles: Loganiaceae (Strychnos species) and Menispermaceae (Abuta, Chondrodendron, and Curarea species). One of the earliest encounters with the poison appears to have been during the exploration of the Lake Maracaibo region in Colombia by Alonso Pérez de Tolosa in 1548. It is pointed out (yet again) that Sir Walter Ralegh did not bring back the poison to Europe in 1595 and that it was Keymis who first came across the word ourari when exploring the lower reaches of the Orinoco in 1596. Gumilla, La Condamine, Ulloa, Veigl, and others gave much additional information about the poison during the 18th century. Scientific studies began in the latter part of the century when Schreber listed the botanical identities of four of the plant components entering into the curare prepared by the Akawai Indians of Surinam. As far as is known, none of these people actually saw curare being made. Thereafter, progress was rapid. Humboldt and Bonpland were the first trained scientists to witness the preparation of the poison, at the very beginning of the 19th century. Subsequent exploration by Martius and Spix, Poeppig, Youd, the Schomburgk brothers, De Castelnau and Deville, Spruce, and others, up to the middle of the century, extended and deepened botanical and ethnological knowledge of curare. Study of its physiology started at about that time with the classical experiments of Rudolf von Koelliker and Claude Bernard.

  11. The History of Neurosurgery at the National Hospital, Queen Square, London, with Some Personal Recollections from 1948 Onwards: The Early Years.

    Science.gov (United States)

    Powell, Michael P

    2017-07-01

    The National Hospital, Queen Square, London was founded as a charitable institution in 1860, becoming the first dedicated neuroscience hospital in the world. Sir Victor Horsley, the first neurosurgeon was appointed in 1886, and since that time, Queen Square neurosurgeons have been prominent on the World neurosurgical stage, including Sir Wylie McKissock and Prof Lindsay Symon, inter alia. This article gives the history taken from both published records and personal stories, recorded by a neurosurgeon who has worked at the hospital for thirty five years. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. History and Surface Condition of the Lewis Chessmen in the Collection of the National Museums Scotland (Hebrides, late 12th-early 13th centuries)

    OpenAIRE

    Tate, Jim; Reiche, I.; Pinzari, F.; Clark, J.; Caldwell, D.

    2013-01-01

    This paper summarises on-going work to examine the surface condition of the 11 chess pieces in the collection of the National Museums Scotland. The chess pieces are part of the hoard found on the isle of Lewis on the west coast of Scotland and are remarkable examples of medieval ivory carving. The aim of the work is to characterise surface features that can be used to draw new information about the materials from which the pieces were made, their history from the period of their manufacture u...

  13. Attractiveness of the landscape: Reconstruction of Early to Middle Holocene landscape and occupation history of Flevoland (central Netherlands)

    Science.gov (United States)

    Van den Biggelaar, Don; Kluiving, Sjoerd; Van Balen, Ronald; Kasse, Kees; Kolen, Jan

    2013-04-01

    The onset of the Holocene (11 500 BP) is marked by climate warming. Climate warming induced the growth of vegetation, which in combination with precipitation and a long period of non-deposition resulted in the formation of soils at the top of the Pleistocene deposits. As these soils have been present at the surface in Flevoland (central Netherlands) during most of the Mesolithic and Neolithic period, the top Pleistocene is an important archaeological level. Prior to the 1990s, prehistoric occupation in wetland areas, such as the Flevoland region, was seen as a challenging living environment due to its marginal nature. However, since the early 1990s a different approach was raised concerning the suitability of wetland occupation by Mesolithic and Neolithic people. Instead of adapting to the natural conditions, prehistoric people selected an area suitable to their way of life. The question remains why it took so long (Mesolithic-Neolithic transition period: 5300-4600 cal BC) for the inhabitants of the Lower Rhine Basin to adapt to the Neolithic lifestyle, in contrast to the adaptation in the loess zone and later in Britain. This difference in adaptation of the Neolithic lifestyle during this transition period cannot be solely explained by a difference in attitude or other cultural arguments. As postglacial sea-level rise caused large parts of Flevoland (central Netherlands) to inundate during the Late Mesolithic and Early Neolithic, the availability of natural resources also changed. It is hypothesized that the availability of a wide range of natural resources, and not exclusively the soil type, predominantly determined the suitability and attractiveness of a region for hunter/gatherers and therefore delayed the transition to a Neolithic lifestyle. To test this hypothesis we have compared two selected areas on the basis of the following parameters: elevation, slope gradient relative to sea-level rise, soil type, past vegetation and the number of archaeological

  14. The Discovery of the Tau Lepton: Part 1, The Early History Through 1975; Part 2, Confirmation of the Discovery and Measurement of Major Properties, 1976--1982

    Science.gov (United States)

    Perl, M. L.

    1994-08-01

    Several previous papers have given the history of the discovery of the {tau} lepton at the Stanford Linear Accelerator Center (SLAC). These papers emphasized (a) the experiments which led to our 1975 publication of the first evidence for the existence of the {tau}, (b) the subsequent experiments which confirmed the existence of the r, and (c) the experiments which elucidated the major properties of the {tau}. That history will be summarized in Part 2 of this talk. In this Part 1, I describe the earlier thoughts and work of myself and my colleagues at SLAC in the 1960's and early 1970's which led to the discovery. I also describe the theoretical and experimental events in particle physics in the 1960's in which our work was immersed. I will also try to describe for the younger generations of particle physicists, the atmosphere in the 1960's. That was before the elucidation of the quark model of hadrons, before the development of the concept of particle generations The experimental paths to program we hot as clear as they are today and we had to cast a wide experimental net.

  15. Incubation Period and Early Natural History Events of the Acute Form of Paracoccidioidomycosis: Lessons from Patients with a Single Paracoccidioides spp. Exposure.

    Science.gov (United States)

    Buccheri, Renata; Khoury, Zarifa; Barata, Luis Carlos Barradas; Benard, Gil

    2016-06-01

    Several aspects of the natural history of paracoccidioidomycosis are still poorly understood. Different from the most prevalent, chronic form of the disease, the acute form represents a continuum from the initial respiratory infection to the full-blown disease, thus providing an opportunity to elucidate the pathogenesis of the early phase of this mycosis. We describe, for the first time, two patients with a single time point exposure to Paracoccidioides spp., for whom we were able to determine the time lapsed between exposure to the fungus Paracoccidioides spp. and the onset of signs and symptoms. In case 1, the pulmonary infection was unapparent, and the first manifestations of the acute/subacute form of the disease presented 4 months after Paracoccidioides spp. In case 2, self-limited, non-specific respiratory and systemic symptoms presented 45 days after infection. Thus, our patients confirm that, within a few weeks of infection, Paracoccidioides spp. affects the pulmonary lymphatic system and initially causes no or mild-to-moderate self-limited symptoms, eventually causing abnormalities on a chest X-ray, all of which spontaneously subside. These cases provide some insight into the natural history of this mycosis, the extent of the host exposure to the fungus, and the determination of its incubation period.

  16. The discovery of the tau lepton: Part 1, The early history through 1975; Part 2, Confirmation of the discovery and measurement of major properties, 1976--1982

    International Nuclear Information System (INIS)

    Perl, M.L.

    1994-08-01

    Several previous papers have given the history of the discovery of the τ lepton at the Stanford Linear Accelerator Center (SLAC). These papers emphasized (a) the experiments which led to our 1975 publication of the first evidence for the existence of the τ, (b) the subsequent experiments which confirmed the existence of the r, and (c) the experiments which elucidated the major properties of the τ. That history will be summarized in Part 2 of this talk. In this Part 1, I describe the earlier thoughts and work of myself and my colleagues at SLAC in the 1960's and early 1970's which led to the discovery. I also describe the theoretical and experimental events in particle physics in the 1960's in which our work was immersed. I will also try to describe for the younger generations of particle physicists, the atmosphere in the 1960's. That was before the elucidation of the quark model of hadrons, before the development of the concept of particle generations The experimental paths to program we hot as clear as they are today and we had to cast a wide experimental net

  17. Medical History's Moment in Art Photography (1920 to 1950): How Lejaren à Hiller and Valentino Sarra Created a Fashion for Scenes of Early Surgery.

    Science.gov (United States)

    Hansen, Bert

    2017-10-01

    Two groups of black-and-white photographs are found in medical rare book rooms and the collections of historically minded physicians. They were created by artists Hiller and Sarra to bring medical history to life for members of the health professions and, to some extent, for a wider public. These were not didactic illustrations for a textbook, but elegant scenes of great figures from Antiquity to the nineteenth century, evocation not documentation even though they were based on research. As pieces of fine art, cherished in portfolios or framed on the wall, the quality prints were intended to stimulate curiosity about the achievements of the figures portrayed. While familiar to some archivists and librarians, these photographs have received almost no attention in the scholarship of medical history. Only one short article examined them in 1983. In recent years these photographers have been given new consideration by scholars of advertising and photography. Using those works and primary sources, this article expands both men's biographies, and it explores their working methods, their artistry, and their achievements. An appreciation of these photographs enlarges our understanding of the place of medical history in American culture during the first half of the twentieth century. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  18. The Gondwana Breakup and the History of the Atlantic and Indian Oceans Unveils Two New Clades for Early Neobatrachian Diversification.

    Directory of Open Access Journals (Sweden)

    Annelise Frazão

    Full Text Available The largest anuran diversity belongs to the Neobatrachia, which harbor more than five thousand extant species. Here, we propose a new hypothesis for the historical aspects of the neobatrachian evolution with a formal biogeographical analysis. We selected 12 genes for 144 neobatrachian genera and four archaeobatrachian outgroups and performed a phylogenetic analysis using a maximum likelihood algorithm with the rapid bootstrap test. We also estimated divergence times for major lineages using a relaxed uncorrelated clock method. According to our time scale, the diversification of crown Neobatrachia began around the end of the Early Cretaceous. Our phylogenetic tree suggests that the first split of Neobatrachia is related to the geological events in the Atlantic and Indian Oceans. Hence, we propose names for these clades that indicate this connection, i.e., Atlanticanura and Indianura. The Atlanticanura is composed of three major neobatrachian lineages: Heleophrynidae, Australobatrachia and Nobleobatrachia. On the other hand, the Indianura consists of two major lineages: Sooglossoidea and Ranoides. The biogeographical analysis indicates that many neobatrachian splits occurred as a result of geological events such as the separation between South America and Africa, between India and the Seychelles, and between Australia and South America.

  19. Early history of extended irreversible thermodynamics (1953-1983): An exploration beyond local equilibrium and classical transport theory

    Science.gov (United States)

    Lebon, G.; Jou, D.

    2015-06-01

    This paper gives a historical account of the early years (1953-1983) of extended irreversible thermodynamics (EIT). The salient features of this formalism are to upgrade the thermodynamic fluxes of mass, momentum, energy, and others, to the status of independent variables, and to explore the consistency between generalized transport equations and a generalized version of the second law of thermodynamics. This requires going beyond classical irreversible thermodynamics by redefining entropy and entropy flux. EIT provides deeper foundations, closer relations with microscopic formalisms, a wider spectrum of applications, and a more exciting conceptual appeal to non-equilibrium thermodynamics. We first recall the historical contributions by Maxwell, Cattaneo, and Grad on generalized transport equations. A thermodynamic theory wide enough to cope with such transport equations was independently proposed between 1953 and 1983 by several authors, each emphasizing different kinds of problems. In 1983, the first international meeting on this theory took place in Bellaterra (Barcelona). It provided the opportunity for the various authors to meet together for the first time and to discuss the common points and the specific differences of their previous formulations. From then on, a large amount of applications and theoretical confirmations have emerged. From the historical point of view, the emergence of EIT has been an opportunity to revisit the foundations and to open new avenues in thermodynamics, one of the most classical and well consolidated physical theories.

  20. Fermilab History and Archives Project | Home

    Science.gov (United States)

    Special Events Early Users Meetings (1979 - 1989) The Tevatron Natural History Discoveries Technology Site Fermilab History and Archives Project Fermilab History and Archives Project Fermi National Accelerator Laboratory Home About the Archives History & Archives Online Request Contact Us Site Index

  1. Contributions of dynamic environmental signals during life-cycle transitions to early life-history traits in lodgepole pine (Pinus contorta Dougl.)

    Science.gov (United States)

    Liu, Yang; Wang, Tongli; El-Kassaby, Yousry A.

    2016-05-01

    Environmental signals are important triggers in the life-cycle transitions and play a crucial role in the life-history evolution. Yet very little is known about the leading ecological factors contributing to the variations of life-history traits in perennial plants. This paper explores both the causes and consequences for the evolution of life-history traits (i.e., seed dormancy and size) in lodgepole pine (Pinus contorta Dougl.) across British Columbia (B.C.), Canada. We selected 83 logepole pine populations covering 22 ecosystem zones of B.C. and through their geographic coordinate, 197 climatic variables were generated accordingly for the reference (1961-1990) and future (2041-2070) periods. We found that dynamic climatic variables rather than constant geographic variables are the true environmental driving forces in seed dormancy and size variations and thus provide reliable predictors in response to global climate change. Evapotranspiration and precipitation in the plant-to-seed chronology are the most critical climate variables for seed dormancy and size variations, respectively. Hence, we predicted that levels of seed dormancy in lodgepole pine would increase across large tracts of B.C. in 2050s. Winter-chilling is able to increase the magnitude of life-history plasticity and lower the bet-hedge strategy in the seed-to-plant transition; however, winter-chilling is likely to be insufficient in the north of 49° N in 2050s, which may delay germination while unfavorable conditions during dry summers may result in adverse consequences in the survival of seedlings owing to extended germination span. These findings provide useful information to studies related to assessments of seed transfer and tree adaptation.

  2. Mid-Pliocene to Early Pleistocene land and sea surface temperature history of NW Australia based on organic geochemical proxies

    Science.gov (United States)

    Smith, R. A.; Castañeda, I. S.; Henderiks, J.; Christensen, B. A.; De Vleeschouwer, D.; Renema, W.; Groeneveld, J.; Bogus, K.; Gallagher, S. J.; Fulthorpe, C.; Expedition 356 Scientists, I.

    2017-12-01

    IODP Expedition 356 Site U1463 is located off the coast of NW Australia, and is sensitive to Indonesian Throughflow (ITF) variability. The ITF is a critical ocean gateway that affects global thermohaline circulation, and regulates the movement of water from the Pacific Ocean into the Indian Ocean. However, despite its importance to the global climate system, few SST reconstructions exist for this region that span the Plio-Pleistocene. Here we investigate both the land and sea-surface temperature (SST) history of NW Australia to constrain ITF variability across the Plio-Pleistocene interval. We apply multiple organic geochemical proxies to this site from 3.4-2.6 Ma, which includes the mid-Pliocene warm period, characterized by slightly higher (2-3°C) global temperatures and similar CO2 concentrations to modern values (e.g. Badger et al. 2013; Bartoli et al., 2011; Dowsett et al., 2009; Hönisch et al., 2009; Pagani et al. 2009; Raymo et al., 1996). SST was reconstructed using TEX86, based on isoprenoid glycerol dialkyl glycerol tetraethers (iGDGTs), and the long-chain diol index (LDI), based on the ratio of diols produced by marine diatoms (Rampen et al., 2012). The Uk'37 index, based on long-chain ketones, was analyzed but cannot be applied as a SST proxy at this site due to the influence of coastal alkenone producers. Additionally, a continental air temperature record was developed using the MBT'5ME proxy, based on branched GDGTs (De Jonge et al., 2014; Weijers et al., 2007). We find that TEX86, LDI and MBT'5Me exhibit similar trends and show relatively warm and stable temperatures from 3.5-2.4 Ma followed by a gradual cooling of 3-4°C from 2.4-1.5 Ma. This cooling corresponds with an arid interval previously identified on the same core by Christensen et al. (2017). Furthermore, we find that the TEX86 record agrees closely with the LR04 global benthic δ18O stack (Lisiecki and Raymo, 2005) and captures glacial/interglacial periods including Marine Isotope Stage

  3. Mobility histories of 7th-9th century AD people buried at early medieval Bamburgh, Northumberland, England.

    Science.gov (United States)

    Groves, S E; Roberts, C A; Lucy, S; Pearson, G; Gröcke, D R; Nowell, G; Macpherson, C G; Young, G

    2013-07-01

    Early Medieval England is described historically as a time when people migrated from the Continent to English shores. This study tests the hypothesis that those buried in the Bowl Hole cemetery, Bamburgh, Northumberland were nonlocally born, because of its royal status. Ninety-one male and female adult, and nonadult, skeletons were studied. Isotope ratios of strontium ((87) Sr/(86) Sr) and oxygen (δ(18) O) were generated for 78 individuals (28 females, 27 males, five "adults," 18 nonadults). The mean Sr value for human enamel was 0.71044, standard deviation (sd) 0.001, and the mean O (δw) value is -5.9‰, sd 1.6‰. Additionally, animal tooth enamel (mean Sr value 0.710587, sd 0.001; mean O value -6.5‰, sd 1.5‰), local soil (mean Sr value 0.709184, sd 0.0006), snail shells (mean Sr value 0.708888, sd 0.0001), and soil samples from a 5 km transect heading inland (mean Sr value 0.709121, sd 0.0003), were analyzed for an indication of the isotopic composition of bioavailable Sr in the modern environment and to assess the impact of sea-spray; water samples from a well, local rivers, and standing water were analyzed for local δ(18) O values (mean O value -6.4‰, relative to VSMOW, sd 2.8‰). Over 50% of those buried at Bamburgh were nonlocal. All ages and both sexes produced "nonlocal" signatures; some suggested childhood origins in Scandinavia, the southern Mediterranean or North Africa. Stature and other indicators of health status indicated differences in quality of life between local and migrant groups. These differences did not extend to burial practices. Copyright © 2013 Wiley Periodicals, Inc.

  4. Multiple Polyploidization Events across Asteraceae with Two Nested Events in the Early History Revealed by Nuclear Phylogenomics.

    Science.gov (United States)

    Huang, Chien-Hsun; Zhang, Caifei; Liu, Mian; Hu, Yi; Gao, Tiangang; Qi, Ji; Ma, Hong

    2016-11-01

    Biodiversity results from multiple evolutionary mechanisms, including genetic variation and natural selection. Whole-genome duplications (WGDs), or polyploidizations, provide opportunities for large-scale genetic modifications. Many evolutionarily successful lineages, including angiosperms and vertebrates, are ancient polyploids, suggesting that WGDs are a driving force in evolution. However, this hypothesis is challenged by the observed lower speciation and higher extinction rates of recently formed polyploids than diploids. Asteraceae includes about 10% of angiosperm species, is thus undoubtedly one of the most successful lineages and paleopolyploidization was suggested early in this family using a small number of datasets. Here, we used genes from 64 new transcriptome datasets and others to reconstruct a robust Asteraceae phylogeny, covering 73 species from 18 tribes in six subfamilies. We estimated their divergence times and further identified multiple potential ancient WGDs within several tribes and shared by the Heliantheae alliance, core Asteraceae (Asteroideae-Mutisioideae), and also with the sister family Calyceraceae. For two of the WGD events, there were subsequent great increases in biodiversity; the older one proceeded the divergence of at least 10 subfamilies within 10 My, with great variation in morphology and physiology, whereas the other was followed by extremely high species richness in the Heliantheae alliance clade. Our results provide different evidence for several WGDs in Asteraceae and reveal distinct association among WGD events, dramatic changes in environment and species radiations, providing a possible scenario for polyploids to overcome the disadvantages of WGDs and to evolve into lineages with high biodiversity. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  5. CONCEPTIONS ABOUT THE HISTORY OF SCIENCE PRESENTED IN THE TEXTBOOKS OF THE EARLY YEARS IN THE STATE OF GOIÁS

    Directory of Open Access Journals (Sweden)

    Jenyffer Soares Estival Murça

    2016-07-01

    Full Text Available The approach of the History of Science (HC in science teaching and textbooks (LD has been gaining ground in discussions involving teacher training, may be one way to combat naive conceptions about the Nature of Science (NDC. The present study sought to identify and analyze the presence of HC in the collection of Sciences textbook intended for the early years of elementary school (1st to 5th year, the largest acquisition for public schools in the state of Goiás. The collection of LDs used was approved in PNLD 2013-2015 collection, Open Door Collection (2011. Insertion of HC, by using categorization information for HC were analyzed. The analysis revealed eight inserted in the collection (Human Body, Energy, Evolution, Interaction, Environment, Health, Technology and Universe Theme, where were possible to identify only 17 inserts HC, surface and related mode of knowledge production. Thus, it is concluded that the insertion of the HC in the early years still gives a very modest way, should be reconsidered and discussed in training courses for teachers.

  6. On the history of the early meteoritic bombardment of the Moon: Was there a terminal lunar cataclysm?

    Science.gov (United States)

    Michael, Greg; Basilevsky, Alexander; Neukum, Gerhard

    2018-03-01

    the considered histograms and relative probability plots not only the 3.87 Ga peak (due to Imbrium basin), but also several secondary peaks caused by the formation of other basins distributed between 3.87 and 4.25 Ga. The lunar terminal cataclysm hypothesis is in disagreement with the distribution of K-Ar ages for the highland rocks of the lunar meteorites. The population of lunar meteorites representing localities randomly distributed over the lunar surface, and thus free from the mentioned sampling bias, shows no ∼3.9 Ga peak as it should, if the cataclysm did occur. We conclude that the statistics of sample ages contradict the terminal cataclysm scenario in the bombardment of the Moon. We also see evidence for the formation of several impact basins between 3.87 and 4.25 Ga which is likewise incompatible with the hypothesis of a short interval cataclysm. There remain other basins, including the largest South Pole - Aitken, the ages of which should be determined in future studies to further clarify the impact history. Sample-return missions targeted to date several key basins need to be planned, and the continued study of lunar meteorites may also bring new details to the general view of the impact bombardment of the Moon.

  7. Investigations into the Early Life-history of Naturally Produced Spring Chinook Salmon and Summer Steelhead in the Grande Ronde River Basin, Annual Report 2001.

    Energy Technology Data Exchange (ETDEWEB)

    Reischauer, Alyssa; Monzyk, Frederick; Van Dyke, Erick

    2003-06-01

    We determined migration timing and abundance of juvenile spring chinook salmon Oncorhynchus tshawytscha and juvenile steelhead/rainbow trout Oncorhynchus mykiss using rotary screw traps on four streams in the Grande Ronde River basin during the 2001 migratory year (MY 2001) from 1 July 2000 through 30 June 2001. Based on migration timing and abundance, two distinct life-history strategies of juvenile spring chinook and O. mykiss could be distinguished. An 'early' migrant group left upper rearing areas from 1 July 2000 through 29 January 2001 with a peak in the fall. A 'late' migrant group descended from upper rearing areas from 30 January 2001 through 30 June 2001 with a peak in the spring. The migrant population of juvenile spring chinook salmon in the upper Grande Ronde River in MY 2001 was very low in comparison to previous migratory years. We estimated 51 juvenile spring chinook migrated out of upper rearing areas with approximately 12% of the migrant population leaving as early migrants to overwinter downstream. In the same migratory year, we estimated 16,067 O. mykiss migrants left upper rearing areas with approximately 4% of these fish descending the upper Grande Ronde River as early migrants. At the Catherine Creek trap, we estimated 21,937 juvenile spring chinook migrants in MY 2001. Of these migrants, 87% left upper rearing areas early to overwinter downstream. We also estimated 20,586 O. mykiss migrants in Catherine Creek with 44% leaving upper rearing areas early to overwinter downstream. At the Lostine River trap, we estimated 13,610 juvenile spring chinook migrated out of upper rearing areas with approximately 77% migrating early. We estimated 16,690 O. mykiss migrated out of the Lostine River with approximately 46% descending the river as early migrants. At the Minam River trap, we estimated 28,209 juvenile spring chinook migrated out of the river with 36% migrating early. During the same period, we estimated 28,113 O. mykiss with

  8. 'Candidatus Megaira polyxenophila' gen. nov., sp. nov.: considerations on evolutionary history, host range and shift of early divergent rickettsiae.

    Directory of Open Access Journals (Sweden)

    Martina Schrallhammer

    Full Text Available "Neglected Rickettsiaceae" (i.e. those harboured by non-hematophagous eukaryotic hosts display greater phylogenetic variability and more widespread dispersal than pathogenic ones; yet, the knowledge about their actual host range and host shift mechanism is scarce. The present work reports the characterization following the full-cycle rRNA approach (SSU rRNA sequence, specific in situ hybridization, and ultrastructure of a novel rickettsial bacterium, herewith proposed as 'Candidatus Megaira polyxenophila' gen. nov., sp. nov. We found it in association with four different free-living ciliates (Diophrys oligothrix, Euplotes octocarinatus, Paramecium caudatum, and Spirostomum sp., all belonging to Alveolata, Ciliophora; furthermore it was recently observed as intracellular occurring in Carteria cerasiformis and Pleodorina japonica (Chlorophyceae, Chlorophyta. Phylogenetic analyses demonstrated the belonging of the candidate new genus to the family Rickettsiaceae (Alphaproteobacteria, Rickettsiales as a sister group of the genus Rickettsia. In situ observations revealed the ability of the candidate new species to colonize either nuclear or cytoplasmic compartments, depending on the host organism. The presence of the same bacterial species within different, evolutionary distant, hosts indicates that 'Candidatus Megaira polyxenophila' recently underwent several distinct host shifts, thus suggesting the existence of horizontal transmission pathways. We consider these findings as indicative of an unexpected spread of rickettsial infections in aquatic communities, possibly by means of trophic interactions, and hence propose a new interpretation of the origin and phylogenetic diversification of rickettsial bacteria.

  9. Notes of John Smith as a Source for the Crimean Khanate History in the early 17th century »

    Directory of Open Access Journals (Sweden)

    N.I. Khrapunov

    2015-12-01

    Full Text Available The paper analyses the account of Tataria collected by famous English adventurer John Smith. In 1602, Smith, a mercenary in Transylvania, was captivated by pillagers and, later, sold into slavery. In spring of 1603 he found himself a slave somewhere in the Azov Sea Area, in the land of the Crimean Khanate. A few months later, Smith succeeded to escape, he reached the Moscow czar’s country, and whence returned to Transylvania. Twenty years after, Smith published his life story in short (1625 and then long version (1630. A considerable part of the story was the account of the author’s adventures among the Turks and the Tatars. Smith widely used other travellers’ accounts (William Biddulph, Antony Jenkinson, William of Rubruck, and Martin Broniovius, collected by famous Samuel Purchas, the first publisher of Smith’s own story. Now we can determine original materials by Smith, based on his personal experience, which describe the Crimean Khanate’s daily life and warfare.

  10. The origin of snakes: revealing the ecology, behavior, and evolutionary history of early snakes using genomics, phenomics, and the fossil record.

    Science.gov (United States)

    Hsiang, Allison Y; Field, Daniel J; Webster, Timothy H; Behlke, Adam D B; Davis, Matthew B; Racicot, Rachel A; Gauthier, Jacques A

    2015-05-20

    The highly derived morphology and astounding diversity of snakes has long inspired debate regarding the ecological and evolutionary origin of both the snake total-group (Pan-Serpentes) and crown snakes (Serpentes). Although speculation abounds on the ecology, behavior, and provenance of the earliest snakes, a rigorous, clade-wide analysis of snake origins has yet to be attempted, in part due to a dearth of adequate paleontological data on early stem snakes. Here, we present the first comprehensive analytical reconstruction of the ancestor of crown snakes and the ancestor of the snake total-group, as inferred using multiple methods of ancestral state reconstruction. We use a combined-data approach that includes new information from the fossil record on extinct crown snakes, new data on the anatomy of the stem snakes Najash rionegrina, Dinilysia patagonica, and Coniophis precedens, and a deeper understanding of the distribution of phenotypic apomorphies among the major clades of fossil and Recent snakes. Additionally, we infer time-calibrated phylogenies using both new 'tip-dating' and traditional node-based approaches, providing new insights on temporal patterns in the early evolutionary history of snakes. Comprehensive ancestral state reconstructions reveal that both the ancestor of crown snakes and the ancestor of total-group snakes were nocturnal, widely foraging, non-constricting stealth hunters. They likely consumed soft-bodied vertebrate and invertebrate prey that was subequal to head size, and occupied terrestrial settings in warm, well-watered, and well-vegetated environments. The snake total-group - approximated by the Coniophis node - is inferred to have originated on land during the middle Early Cretaceous (~128.5 Ma), with the crown-group following about 20 million years later, during the Albian stage. Our inferred divergence dates provide strong evidence for a major radiation of henophidian snake diversity in the wake of the Cretaceous-Paleogene (K

  11. Behavioral Impulsivity and Risk-Taking Trajectories Across Early Adolescence in Youths With and Without Family Histories of Alcohol and Other Drug Use Disorders.

    Science.gov (United States)

    Dougherty, Donald M; Lake, Sarah L; Mathias, Charles W; Ryan, Stacy R; Bray, Bethany C; Charles, Nora E; Acheson, Ashley

    2015-08-01

    Youths with family histories of alcohol and other drug use disorders (FH+) are at increased susceptibility for developing substance use disorders relative to those without such histories (FH-). This vulnerability may be related to impaired adolescent development of impulse control and elevated risk-taking. However, no previous studies have prospectively examined impulse control and risk-taking in FH+ youth across adolescence. A total of 386 pre-adolescents (305 FH+, 81 FH-; aged 10 to 12) with no histories of regular alcohol or other drug use were compared on behavioral measures of impulsivity including delay discounting, response initiation (Immediate Memory Task), response inhibition impulsivity (GoStop Impulsivity Paradigm), and risk-taking (Balloon Analogue Risk Task-Youth). Youths completed these laboratory tasks every 6 months, allowing for the examination of 10- to 15-year-olds. Hierarchical linear modeling was used to characterize the development of impulse control and risk-taking as shown in performance of these tasks throughout adolescence. We found that (i) FH+ youths had increased levels of delay discounting and response inhibition impulsivity at study entry; (ii) regardless of FH status, all youths had relatively stable delay discounting across time, improvements in response inhibition and response initiation impulsivity, and increased risk-taking; and (iii) although FH+ youths had increased response inhibition impulsivity at pre-adolescence, these differences were negligible by mid-adolescence. Heightened delay discounting in FH+ pre-adolescents coupled with normal adolescent increases in risk-taking may contribute to their increased susceptibility toward problem substance use in adolescence. Copyright © 2015 by the Research Society on Alcoholism.

  12. A History of Anterior Cruciate Ligament Reconstruction at the National Football League Combine Results in Inferior Early National Football League Career Participation.

    Science.gov (United States)

    Provencher, Matthew T; Bradley, James P; Chahla, Jorge; Sanchez, Anthony; Beaulieu-Jones, Brendin R; Arner, Justin W; Kennedy, Nicholas I; Sanchez, George; Kennedy, Mitchell I; Moatshe, Gilbert; Cinque, Mark E; LaPrade, Robert F

    2018-05-19

    To evaluate whether players with a history of an anterior cruciate ligament reconstruction (ACLR) before the National Football League (NFL) Combine played or started fewer games and/or participated in fewer eligible snaps compared with NFL Combine participants without a history of knee injury or surgery. We performed a retrospective review of all players who participated in the NFL Combine between 2009 and 2015 and who had a history of an ACLR. NFL Combine participants were included if they had a previous ACLR or combined anterior cruciate ligament (ACL) injury and nonoperatively managed medial collateral ligament injury. The number of games started, number of games played, draft number, overall draft pick, and snap percentage for each position were determined. The mean value of each outcome metric was compared between case and control players. We identified 110 players who had an ACL injury (n = 76) or a combined ACL and medial collateral ligament injury (n = 34). Players in the ACLR group had a significantly worse mean draft pick number (difference of 30.2, P = .002) and mean draft round (difference of 0.8, P = .019) versus controls. Compared with control players, players in the ACLR group started and played significantly fewer games in both season 1 (difference of 2.7 games started, P < .001; difference of 2.7 games played, P < .001) and season 2 (difference of 7.4 games started, P < .001; difference of 3.0 games played, P = .003) and had a significantly lower snap percentage in both season 1 (difference of 23.1%, P < .001) and season 2 (difference of 24.0%, P < .001). Athletes at the NFL Combine who previously underwent an ACLR had significantly lower early-career NFL player metrics, including fewer games started, fewer games played, and a lower snap percentage, than uninjured controls. Defensive linemen, defensive backs, and linebackers were the 3 most affected positions. Players with a prior ACLR and combined meniscal-chondral pathology had

  13. An Ecological Analysis of the Effects of Deviant Peer Clustering on Sexual Promiscuity, Problem Behavior, and Childbearing from Early Adolescence to Adulthood: An Enhancement of the Life History Framework

    Science.gov (United States)

    Dishion, Thomas J.; Ha, Thao; Veronneau, Marie-Helene

    2012-01-01

    The authors propose that peer relationships should be included in a life history perspective on adolescent problem behavior. Longitudinal analyses were used to examine deviant peer clustering as the mediating link between attenuated family ties, peer marginalization, and social disadvantage in early adolescence and sexual promiscuity in middle…

  14. An Ecological Analysis of the Effects of Deviant Peer Clustering on Sexual Promiscuity, Problem Behavior, and Childbearing From Early Adolescence to Adulthood: An Enhancement of the Life History Framework

    NARCIS (Netherlands)

    Dishion, T.J.; Ha, P.T.; Veronneau, M.H.

    2012-01-01

    The authors propose that peer relationships should be included in a life history perspective on adolescent problem behavior. Longitudinal analyses were used to examine deviant peer clustering as the mediating link between attenuated family ties, peer marginalization, and social disadvantage in early

  15. Impacts of ocean acidification on early life-history stages and settlement of the coral-eating sea star Acanthaster planci.

    Science.gov (United States)

    Uthicke, Sven; Pecorino, Danilo; Albright, Rebecca; Negri, Andrew Peter; Cantin, Neal; Liddy, Michelle; Dworjanyn, Symon; Kamya, Pamela; Byrne, Maria; Lamare, Miles

    2013-01-01

    Coral reefs are marine biodiversity hotspots, but their existence is threatened by global change and local pressures such as land-runoff and overfishing. Population explosions of coral-eating crown of thorns sea stars (COTS) are a major contributor to recent decline in coral cover on the Great Barrier Reef. Here, we investigate how projected near-future ocean acidification (OA) conditions can affect early life history stages of COTS, by investigating important milestones including sperm motility, fertilisation rates, and larval development and settlement. OA (increased pCO2 to 900-1200 µatm pCO2) significantly reduced sperm motility and, to a lesser extent, velocity, which strongly reduced fertilization rates at environmentally relevant sperm concentrations. Normal development of 10 d old larvae was significantly lower under elevated pCO2 but larval size was not significantly different between treatments. Settlement of COTS larvae was significantly reduced on crustose coralline algae (known settlement inducers of COTS) that had been exposed to OA conditions for 85 d prior to settlement assays. Effect size analyses illustrated that reduced settlement may be the largest bottleneck for overall juvenile production. Results indicate that reductions in fertilisation and settlement success alone would reduce COTS population replenishment by over 50%. However, it is unlikely that this effect is sufficient to provide respite for corals from other negative anthropogenic impacts and direct stress from OA and warming on corals.

  16. A TALE OF A RICH CLUSTER AT z ∼ 0.8 AS SEEN BY THE STAR FORMATION HISTORIES OF ITS EARLY-TYPE GALAXIES

    Energy Technology Data Exchange (ETDEWEB)

    Ferré-Mateu, Anna [Subaru Telescope, Hilo, HI 96720 (United States); Sánchez-Blázquez, Patricia [Departamento de Física Teórica, Universidad Autónoma de Madrid, E-28049 Cantoblanco, Madrid (Spain); Vazdekis, Alexandre; De la Rosa, Ignacio G., E-mail: aferre@naoj.org [Instituto de Astrofísica de Canarias, E-38205 La Laguna, Tenerife (Spain)

    2014-12-20

    We present a detailed stellar population analysis for a sample of 24 early-type galaxies (ETGs) belonging to the rich cluster RX J0152.7-1357 at z = 0.83. We have derived the age, metallicity, abundance pattern, and star formation history (SFH) for each galaxy individually to further characterize this intermediate-z reference cluster. We then study how these stellar population parameters depend on the local environment. This provides a better understanding on the formation timescales and subsequent evolution of the substructures in this cluster. We have also explored the evolutionary link between z ∼ 0.8 ETGs and those in the local universe by comparing the trends that the stellar population parameters followed with galaxy velocity dispersion at each epoch. We find that the ETGs in Coma are consistent with being the (passively evolving) descendants of the ETG population in RX J10152.7-1357. Furthermore, our results favor a downsizing picture, where the subclumps centers were formed first. These central parts contain the most massive galaxies, which formed the bulk of their stars in a short, burst-like event at high z. On the contrary, the cluster outskirts are populated with less-massive, smaller galaxies that show a wider variety of SFHs. In general, they present extended star formation episodes over cosmic time, which seems to be related to their posterior incorporation into the cluster around 4 Gyr after the initial event of formation.

  17. “The wondrous eyes of a new technology”—a history of the early electroencephalography (EEG) of psychopathy, delinquency, and immorality

    Science.gov (United States)

    Schirmann, Felix

    2014-01-01

    This article presents a history of the early electroencephalography (EEG) of psychopathy, delinquency, and immorality in Great Britain and the United States in the 1940s and 1950s. Then, EEG was a novel research tool that promised ground-breaking insights in psychiatry and criminology. Experts explored its potential regarding the diagnosis, classification, etiology, and treatment of unethical and unlawful persons. This line of research yielded tentative and inconsistent findings, which the experts attributed to methodological and theoretical shortcomings. Accordingly, the scientific community discussed the reliability, validity, and utility of EEG, and launched initiatives to calibrate and standardize the novel tool. The analysis shows that knowledge production, gauging of the research tool, and attempts to establish credibility for EEG in the study of immoral persons occurred simultaneously. The paper concludes with a reflection on the similarities between EEG and neuroimaging—the prime research tool in the current neuroscience of morality—and calls for a critical assessment of their potentials and limitations in the study of immorality and crime. PMID:24860464

  18. The Early History of Protocells

    DEFF Research Database (Denmark)

    Hanczyc, Martin

    2008-01-01

    experiments such as the fermentation of sugar into ethanol (a biological process) by the nonliving yeast extracts of the Buchner brothers in 1897 further opened the door to exploration of the grey space that conceptually lies between chemistry and biology (Friedmann, 1997). Here I present a brief historical...

  19. Roman Togatus Statue Found in Salamanca

    Directory of Open Access Journals (Sweden)

    Manuel Carlos JIMÉNEZ GONZÁLEZ

    2016-11-01

    Full Text Available We disclose the finding, during a recent archaeological work in the city of Salamanca, of two marble fragments belonging to a statue of a togatus, which we believe could have been part of the decorative and propagandistic program of the forum in the time of the Early Empire. The data that we have about the location and layout of the forum and the various public spaces and buildings that formed it are indeed very limited. The location of this sculpture would confirm and might even provide some more information in this regard. The discovery was made out of archaeological context, because there is no historical stratigraphic sequence in the basement of the site where it appeared, the material and formal characteristics that can be seen in sculpture, along with the space in which it was found, as well as the archaeological context of the area in a broader sense, allow some clarifications on a number of aspects of formal, chronological and interpretive order relating to it.

  20. Did John B. Watson Really "Found" Behaviorism?

    Science.gov (United States)

    Malone, John C

    2014-05-01

    Developments culminating in the nineteenth century, along with the predictable collapse of introspective psychology, meant that the rise of behavioral psychology was inevitable. In 1913, John B. Watson was an established scientist with impeccable credentials who acted as a strong and combative promoter of a natural science approach to psychology when just such an advocate was needed. He never claimed to have founded "behavior psychology" and, despite the acclaim and criticism attending his portrayal as the original behaviorist, he was more an exemplar of a movement than a founder. Many influential writers had already characterized psychology, including so-called mental activity, as behavior, offered many applications, and rejected metaphysical dualism. Among others, William Carpenter, Alexander Bain, and (early) Sigmund Freud held views compatible with twentieth-century behaviorism. Thus, though Watson was the first to argue specifically for psychology as a natural science, behaviorism in both theory and practice had clear roots long before 1913. If behaviorism really needs a "founder," Edward Thorndike might seem more deserving, because of his great influence and promotion of an objective psychology, but he was not a true behaviorist for several important reasons. Watson deserves the fame he has received, since he first made a strong case for a natural science (behaviorist) approach and, importantly, he made people pay attention to it.

  1. Impact History of the Moon

    Science.gov (United States)

    Cohen, B. A.; Bottke, W. F.; Norman, M. V.; van der Bogert, C. H.; Fassett, C. I.; Hiesinger, H.; Joy, K. H.; Mazrouei, S. A.; Nemchin, A.; Neumann, G. A.; Zellner, N. E. B.

    2018-04-01

    Establishing an absolute planetary chronology has important ramifications for understanding the early structure of the solar system and the geologic history of the planets. The Moon is the cornerstone for understanding this impact history.

  2. An Examination of the Use of Lists of Recent Publications Found in Selected Journals in British and European History for Collection Development and Current Awareness by Librarians and Historians: A Master's Paper for the M.S. in L.S. Degree, July, 1985.

    Science.gov (United States)

    Barringer, Sallie H.

    This master's paper examines the use, by historians and librarians, of lists of recent publications, bibliographies, and reviews appearing in selected British and European history journals. Part 1 contains: (1) an introduction; (2) background information; (3) a literature review; (4) the problem statement; (5) a definition of terms; and (6) the…

  3. Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress.

    Science.gov (United States)

    Myers, Amanda J; Williams, Leanne; Gatt, Justine M; McAuley-Clark, Erica Z; Dobson-Stone, Carol; Schofield, Peter R; Nemeroff, Charles B

    2014-12-01

    Oxytocin is a neuropeptide that is involved in the regulation of mood, anxiety and social biology. Genetic variation in the oxytocin receptor gene (OXTR) has been implicated in anxiety, depression and related stress phenotypes. It is not yet known whether OXTR interacts with other risk factors such as early life trauma to heighten the severity of experienced anxiety and depression. In this study, we examined genotypes in 653 individuals and tested whether SNP variation in OXTR correlates with severity of features of self-reported experience on the Depression Anxiety and Stress Scale (DASS), and whether this correlation is enhanced when early life trauma is taken into account. We also assessed the effects of OXTR SNPs on RNA expression levels in two separate brain tissue cohorts totaling 365 samples. A significant effect of OXTR genotype on DASS anxiety, stress and depression scores was found and ELS events, in combination with several different OXTR SNPs, were significantly associated with differences in DASS scores with one SNP (rs139832701) showing significant association or a trend towards association for all three measures. Several OXTR SNPs were correlated with alterations in OXTR RNA expression and rs3831817 replicated across both sets of tissues. These results support the hypothesis that the oxytocin system plays a role in the pathophysiology of mood and anxiety disorders. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Angiogenic Factor Profiles in Pregnant Women With a History of Early-Onset Severe Preeclampsia Receiving Low-Molecular-Weight Heparin Prophylaxis.

    Science.gov (United States)

    Lecarpentier, Edouard; Gris, Jean Christophe; Cochery-Nouvellon, Eva; Mercier, Erick; Touboul, Cyril; Thadhani, Ravi; Karumanchi, S Ananth; Haddad, Bassam

    2018-01-01

    To evaluate whether daily low-molecular-weight (LMW) heparin prophylaxis during pregnancy alters profile of circulating angiogenic factors that have been linked with the pathogenesis of preeclampsia and fetal growth restriction. This is a planned ancillary study of the Heparin-Preeclampsia trial, a randomized trial in pregnant women with a history of severe early-onset preeclampsia (less than 34 weeks of gestation). In the parent study, all women were treated with aspirin and then randomized to receive LMW heparin or aspirin alone. In this study, we measured serum levels of circulating angiogenic factors (soluble fms-like tyrosine kinase-1, placental growth factor, and soluble endoglin by immunoassay) at the following gestational windows: 10-13 6/7 weeks, 14-17 6/7 weeks, 18-21 6/7 weeks, 22-25 6/7 weeks, 26-29 6/7 weeks, 30-33 6/7 weeks, and 34-37 6/7 weeks. Samples were available from 185 patients: LMW heparin+aspirin (n=92) and aspirin alone (n=93). The two groups had comparable baseline characteristics and had similar adverse composite outcomes (35/92 [38.0%] compared with 36/93 [38.7%]; P=.92). There were no significant differences in serum levels of soluble fms-like tyrosine kinase-1, placental growth factor, and soluble endoglin in the participants who received LMW heparin and aspirin compared with those who received aspirin alone regardless of gestational age period. Finally, women who developed an adverse composite outcome at less than 34 weeks of gestation demonstrated significant alterations in serum angiogenic profile as early as 10-13 6/7 weeks that was most dramatic 6-8 weeks preceding delivery. Prophylactic LMW heparin therapy when beginning from before 14 weeks of gestation with aspirin during pregnancy is not associated with an improved angiogenic profile. This may provide a molecular explanation for the lack of clinical benefit noted in recent trials. ClinicalTrials.gov, NCT00986765.

  5. An ecological analysis of the effects of deviant peer clustering on sexual promiscuity, problem behavior, and childbearing from early adolescence to adulthood: an enhancement of the life history framework.

    Science.gov (United States)

    Dishion, Thomas J; Ha, Thao; Véronneau, Marie-Hélène

    2012-05-01

    The authors propose that peer relationships should be included in a life history perspective on adolescent problem behavior. Longitudinal analyses were used to examine deviant peer clustering as the mediating link between attenuated family ties, peer marginalization, and social disadvantage in early adolescence and sexual promiscuity in middle adolescence and childbearing by early adulthood. Specifically, 998 youths, along with their families, were assessed at age 11 years and periodically through age 24 years. Structural equation modeling revealed that the peer-enhanced life history model provided a good fit to the longitudinal data, with deviant peer clustering strongly predicting adolescent sexual promiscuity and other correlated problem behaviors. Sexual promiscuity, as expected, also strongly predicted the number of children by ages 22-24 years. Consistent with a life history perspective, family social disadvantage directly predicted deviant peer clustering and number of children in early adulthood, controlling for all other variables in the model. These data suggest that deviant peer clustering is a core dimension of a fast life history strategy, with strong links to sexual activity and childbearing. The implications of these findings are discussed with respect to the need to integrate an evolutionary-based model of self-organized peer groups in developmental and intervention science.

  6. Columbia River White Sturgeon (Acipenser Transmontanus) Population Genetics and Early Life History Study, January 1, 1986 to December 31, 1986, Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Brannon, Ernest L.

    1986-12-01

    The 1986 Columbia River white sturgeon investigations continued to assess genetic variability of sturgeon populations isolated in various areas of the Columbia River, and to examine environmental factors in the habitat that may affect early life history success. Baseline data have been collected for three character sets. Twenty-eight loci have been analyzed for differences using electrophoresis, snout shapes were assessed for multivariate distinction, and scute counts have been examined as an index of variability. Fish that reside in the mid-Columbia and lower river have been sufficiently characterized by electrophoresis to compare with up-river areas. To date, few electrophoretic differences have been identified. However, Lake Roosevelt sturgeon sample size will be increased to determine if some of the observed differences from lower river fish are significant. Snout shape has been shown to be easily quantifiable using the digitizing technique. Scute count data initially indicate that variability exists within as well as between areas. Patterns of differentiation of one or more of these data sets may be used to formulate stock transplant guidelines essential for proper management or enhancement of this species. The historical habitat available to sturgeon in the Columbia River has changed through the development of hydroelectric projects. Dams have reduced the velocity and turbulence, and increased light penetration in the water column from less silt. These changes have affected the ability of sturgeon to feed and have made them more vulnerable to predation, which appear to have altered the ability of populations isolated in the reservoirs to sustain themselves. Present studies support the theory that both the biological and physical habitat characteristics of the Columbia River are responsible for reduced sturgeon survival, and justify consideration of enhancement initiatives above Bonneville to improve sturgeon reproductive success.

  7. Cortisol regulation in 12-month-old human infants: Associations with the infants' early history of breastfeeding and co-sleeping

    NARCIS (Netherlands)

    Beijers, R.; Riksen-Walraven, J.M.A.; Weerth, C. de

    2013-01-01

    Experiences during early life are suggested to affect the physiological systems underlying stress responses, including the hypothalamic–pituitary–adrenal axis (HPA axis). While stressful early experiences have been associated with dysregulated HPA-axis functioning, positive early experiences, i.e.

  8. International Research Roundtable “New Approaches to the Study of Eurasian History in the early 21st century: A Comparative Analysis of American, European, and post-Soviet Experiences” (December 19, 2014 »

    Directory of Open Access Journals (Sweden)

    G.E. Sabdenova

    2015-06-01

    Full Text Available The International Research Roundtable “New Approaches to the Study of Eurasian History in the early 21st century: A Comparative Analysis of American, European, and post-Soviet Experiences” was held in Almaty December 19, 2014. The round table was organized by the Faculty of History, Archaeology, and Ethnology of the Al-Farabi Kazakh National University. The conference was attended by renowned experts. Professor Talas Omarbekovich Omarbekov was the moderator of this round table. Each report was followed by a discussion. Among others, the following reports were presented at the conference: Uli Schamiloglu, “The Plague in the Time of Justinian and Central Eurasian History”; G.A. Bordyugov, “An Applied History: Developing Methods of Historical Knowledge in the Situation of an Interdisciplinary Inevitability”; Mehmet Şahingöz, “Problems of Studying the History of Jungar Invasion and Its Influence on the Turkic World in Turkey”; R.R. Gallyamov, “Etnogony as a Way to Study the Early Ethnogenesis and Ethnic History of Turkic Peoples of Central Eurasia”; Mehmet Derviş, “Problems of Studying the History of the Turkic Peoples in the Context of World History”; Roman Hautala, “On the Need of Introduction in Academic Circulation of New Sources on the Golden Horde History”; Ilnur Mirgaleev, “Activities of the Center for Research on the Golden Horde History”; Svetlana Hautala, “About Discrepancy of Information of the Written Sources and Material Artifacts: Herodotus on the Scythian Cauldrons”.

  9. STUDENT’S VIEW ON THE FOUNDING OF THE CITY

    Directory of Open Access Journals (Sweden)

    LYSENKO G. I.

    2017-03-01

    Full Text Available Formulation of the problem. Today in Ukraine, we can observe the process of recovery of historical memory at all levels – national, local, personal. Unfortunately, not every resident of our city knows the history of his native land, although it is known that people who do not know their own history, cannot understand the present and build the future. This statement is particularly relevant for today's youth, living in the era of change, to understand which it is necessary to look into the past of their country and city. Analysis of the research. Among the various studies that reveal in detail the early history of the city on the Dnieper River, an important place belongs to works by D. Yavornytsky, S. Revsky, G. Gulyaev, V. Starostin, M. Kavun and others. The purpose of the article is making a comparative analysis of the causes and consequences of two construction projects of Katerynoslav on the Kilchen’ and on the Dnipro. Conclusion. The early history of our city demonstrates that Russian colonization power understood the strategic importance of its location, as there were here from the sixteenth century Ukrainian settlements such as Samar, Old Kodak, New Kodak and more. The Russian concept of building “the third imperial capital" was defeated, as it was being held only on the personal enthusiasm of Catherine II and her favorite Potemkin, but the real development of the city as an industrial center of Dnieper region began only in the late nineteenth century. Rich historical and cultural heritage on the territory of modern city creates excellent conditions for the development of diverse tourism industry, which can direct metropolis life in a new direction.

  10. History of Asian American psychology.

    Science.gov (United States)

    Leong, Frederick T L; Okazaki, Sumie

    2009-10-01

    An overview of the history of Asian American psychology is provided by reviewing the context for the development of the field as well as the early founding of the Asian American Psychological Association (AAPA). The presidents of AAPA as well as key events and conferences are noted. The involvement of AAPA leaders in national mental health policies and activities are reviewed. The substantive areas of Asian American psychology and the education and training of Asian American psychologists are also discussed. The article ends with some comments about the future of Asian American psychology. Copyright 2009 APA, all rights reserved.

  11. The founding of CEBAF, 1979 to 1987

    International Nuclear Information System (INIS)

    Westfall, C.

    1995-01-01

    In early 1979 a group of physicists assembled at the University of Virginia (UVa) for a conference entitled ''Future Possibilities for Electron Accelerators.'' In the audience sat an organizer of the conference, UVa professor James McCarthy. While listening to talks by Gregory Loew of the Stanford Linear Accelerator Center (SLAC) and Roger Servranckx of the University of Saskatchewan, McCarthy got very excited. Both discussed new approaches to producing an almost continuous stream of electrons with improved designs for pulse stretcher rings that could be built within a reasonable budget. McCarthy saw the possibility of realizing a dream. This dream had its origins in the 1950s, when Robert Hofstadter, McCarthy's thesis advisor, made groundbreaking discoveries at Stanford's High Energy Physics Laboratory (HEPL) about the internal structure of nuclei and nucleons. For these experiments Hofstadter used Mark III, the most advanced in a series of electron accelerators designed by William Hansen, who pioneered methods of high frequency acceleration of electrons. The work by Hofstadter and Hansen led to two productive lines of inquiry. One group of researchers studied particle production using electrons at higher energies, which led to the construction in the 1960s of SLAC at Stanford. Another group of researchers, which included McCarthy, investigated nuclear structure with more modest increases in energy accompanied by increases in the duty factor of the electron beam. This line of inquiry, electro-nuclear physics, led in the 1960s and 1970s to a succession of accelerators, including a $7.2 million high duty factor 400 MeV linear accelerator (linac) completed in 1972 at the Bates Laboratory at the Massachusetts Institute of Technology (Bates-MIT), and ambitious attempts to develop untried technologies to further boost energy and duty factor, most notably the effort to develop superconducting radiofrequency (srf) accelerating technology at HEPL. By 1979 electro

  12. IMPACT OF HATCH-DATE ON EARLY LIFE GROWTH AND SURVIVAL OF MUELLER’S PEARLSIDE (MAUROLICUS MUELLERI) LARVAE, AND LIFE-HISTORY CONSEQUENCES

    KAUST Repository

    Folkvord, Arild; Gundersen, Geir; Albretsen, Jon; Asplin, Lars L; Kaartvedt, Stein; Giske, Jarl

    2015-01-01

    and variable survival due to short term fluctuations in environmental conditions indicate that multiple batch spawning is an adequately evolved life history strategy for marine planktivorous fish such as M. muelleri.

  13. History of Science and History of Philologies.

    Science.gov (United States)

    Daston, Lorraine; Most, Glenn W

    2015-06-01

    While both the sciences and the humanities, as currently defined, may be too heterogeneous to be encompassed within a unified historical framework, there is good reason to believe that the history of science and the history of philologies both have much to gain by joining forces. This collaboration has already yielded striking results in the case of the history of science and humanist learning in early modern Europe. This essay argues that first, philology and at least some of the sciences (e.g., astronomy) remained intertwined in consequential ways well into the modern period in Western cultures; and second, widening the scope of inquiry to include other philological traditions in non-Western cultures offers rich possibilities for a comparative history of learned practices. The focus on practices is key; by shifting the emphasis from what is studied to how it is studied, deep commonalities emerge among disciplines--and intellectual traditions--now classified as disparate.

  14. The impact of family history of breast cancer on knowledge, attitudes, and early detection practices of Mexican women along the Mexico-US border.

    Science.gov (United States)

    Bird, Yelena; Banegas, Matthew P; Moraros, John; King, Sasha; Prapasiri, Surasri; Thompson, Beti

    2011-10-01

    Rates of breast cancer (BC) have increased in Mexico, with the highest incidence and mortality rates observed in the northern Mexican states. This study aimed to describe the BC knowledge, attitudes and screening practices among Mexican women with and without a family history of BC residing along the Mexico-US border, and identify factors associated with screening behaviors. One hundred and twenty eight Mexican women aged 40 and older completed an interviewer-administered questionnaire on sociodemographic characteristics, knowledge, family history, and screening practices. There were no significant differences between Mexican women with and without a family history. Over 60% of women in both groups had never had a mammogram/breast ultrasound, and more than 50% had never obtained a clinical breast exam. Age, marital status, insurance, and breast cancer knowledge significantly influenced BC screening behaviors among Mexican women. Further research is needed to examine other key factors associated with screening utilization, in effort of improving BC rates.

  15. Well-Founded Belief and Perceptual Justification

    DEFF Research Database (Denmark)

    Broncano-Berrocal, Fernando

    2016-01-01

    According to Alan Millar, justified beliefs are well-founded beliefs. Millar cashes out the notion of well-foundedness in terms of having an adequate reason to believe something and believing it for that reason. To make his account of justified belief compatible with perceptual justification he...

  16. Establishment probability in newly founded populations

    Directory of Open Access Journals (Sweden)

    Gusset Markus

    2012-06-01

    Full Text Available Abstract Background Establishment success in newly founded populations relies on reaching the established phase, which is defined by characteristic fluctuations of the population’s state variables. Stochastic population models can be used to quantify the establishment probability of newly founded populations; however, so far no simple but robust method for doing so existed. To determine a critical initial number of individuals that need to be released to reach the established phase, we used a novel application of the “Wissel plot”, where –ln(1 – P0(t is plotted against time t. This plot is based on the equation P0t=1–c1e–ω1t, which relates the probability of extinction by time t, P0(t, to two constants: c1 describes the probability of a newly founded population to reach the established phase, whereas ω1 describes the population’s probability of extinction per short time interval once established. Results For illustration, we applied the method to a previously developed stochastic population model of the endangered African wild dog (Lycaon pictus. A newly founded population reaches the established phase if the intercept of the (extrapolated linear parts of the “Wissel plot” with the y-axis, which is –ln(c1, is negative. For wild dogs in our model, this is the case if a critical initial number of four packs, consisting of eight individuals each, are released. Conclusions The method we present to quantify the establishment probability of newly founded populations is generic and inferences thus are transferable to other systems across the field of conservation biology. In contrast to other methods, our approach disaggregates the components of a population’s viability by distinguishing establishment from persistence.

  17. Investigations into the Early Life History of Naturally Produced Spring Chinook Salmon and Summer Steelhead in the Grande Ronde River Basin : Annual Report 2000 : Project Period 1 October 1999 to 30 November 2000.

    Energy Technology Data Exchange (ETDEWEB)

    Monzyk, Fred R.

    2002-06-01

    The authors determined migration timing and abundance of juvenile spring chinook salmon Oncorhynchus tshawytscha and juvenile steelhead/rainbow trout O. mykiss from three populations in the Grande Ronde River basin. Based on migration timing and abundance, two distinct life-history strategies of juvenile spring chinook and O.mykiss could be distinguished. An early migrant group left upper rearing areas from July through January with a peak in the fall. A late migrant group descended from upper rearing areas from February through June with a peak in the spring.

  18. Investigations into the early life history of naturally produced spring chinook salmon and summer steelhead in the Grande Ronde River Basin : annual report 2000 : project period 1 October 1999 to 30 November 2000.; ANNUAL

    International Nuclear Information System (INIS)

    Monzyk, Fred R.; United States. Bonneville Power Administration. Environment, Fish and Wildlife.

    2002-01-01

    The authors determined migration timing and abundance of juvenile spring chinook salmon Oncorhynchus tshawytscha and juvenile steelhead/rainbow trout O. mykiss from three populations in the Grande Ronde River basin. Based on migration timing and abundance, two distinct life-history strategies of juvenile spring chinook and O.mykiss could be distinguished. An early migrant group left upper rearing areas from July through January with a peak in the fall. A late migrant group descended from upper rearing areas from February through June with a peak in the spring

  19. Bohmian histories and decoherent histories

    International Nuclear Information System (INIS)

    Hartle, James B.

    2004-01-01

    The predictions of the Bohmian and the decoherent (or consistent) histories formulations of the quantum mechanics of a closed system are compared for histories--sequences of alternatives at a series of times. For certain kinds of histories, Bohmian mechanics and decoherent histories may both be formulated in the same mathematical framework within which they can be compared. In that framework, Bohmian mechanics and decoherent histories represent a given history by different operators. Their predictions for the probabilities of histories of a closed system therefore generally differ. However, in an idealized model of measurement, the predictions of Bohmian mechanics and decoherent histories coincide for the probabilities of records of measurement outcomes. The formulations are thus difficult to distinguish experimentally. They may differ in their accounts of the past history of the Universe in quantum cosmology

  20. FOUNDING OF THE DISTRICT HOSPITAL IN NIS

    Directory of Open Access Journals (Sweden)

    Misa Zivic

    2007-01-01

    Full Text Available After the liberation of Nis from the Turks which took place on January 11th, 1878, there were two military hospitals: one was next to The Skull Tower and the other on the road to Leskovac and there was Islahana the civil institution which was not the forerunner of the district hospital in Nis. At first, they founded the military hospital in Nis in 1878 and then they founded The District Hospital on July 17th in 1881. The first director of the District hospital was Anton Zajicek. He is also the first graduated medical doctor in Nis. The District Hospital was situated on the left bank of the Nisava river in a private house.

  1. Bioactive Compounds Found in Brazilian Cerrado Fruits.

    Science.gov (United States)

    Bailão, Elisa Flávia Luiz Cardoso; Devilla, Ivano Alessandro; da Conceição, Edemilson Cardoso; Borges, Leonardo Luiz

    2015-10-09

    Functional foods include any natural product that presents health-promoting effects, thereby reducing the risk of chronic diseases. Cerrado fruits are considered a source of bioactive substances, mainly phenolic compounds, making them important functional foods. Despite this, the losses of natural vegetation in the Cerrado are progressive. Hence, the knowledge propagation about the importance of the species found in Cerrado could contribute to the preservation of this biome. This review provides information about Cerrado fruits and highlights the structures and pharmacologic potential of functional compounds found in these fruits. Compounds detected in Caryocar brasiliense Camb. (pequi), Dipteryx alata Vog. (baru), Eugenia dysenterica DC. (cagaita), Eugenia uniflora L. (pitanga), Genipa americana L. (jenipapo), Hancornia speciosa Gomes (mangaba), Mauritia flexuosa L.f. (buriti), Myrciaria cauliflora (DC) Berg (jabuticaba), Psidium guajava L. (goiaba), Psidium spp. (araçá), Solanum lycocarpum St. Hill (lobeira), Spondias mombin L. (cajá), Annona crassiflora Mart. (araticum), among others are reported here.

  2. Bioactive Compounds Found in Brazilian Cerrado Fruits

    Directory of Open Access Journals (Sweden)

    Elisa Flávia Luiz Cardoso Bailão

    2015-10-01

    Full Text Available Functional foods include any natural product that presents health-promoting effects, thereby reducing the risk of chronic diseases. Cerrado fruits are considered a source of bioactive substances, mainly phenolic compounds, making them important functional foods. Despite this, the losses of natural vegetation in the Cerrado are progressive. Hence, the knowledge propagation about the importance of the species found in Cerrado could contribute to the preservation of this biome. This review provides information about Cerrado fruits and highlights the structures and pharmacologic potential of functional compounds found in these fruits. Compounds detected in Caryocar brasiliense Camb. (pequi, Dipteryx alata Vog. (baru, Eugenia dysenterica DC. (cagaita, Eugenia uniflora L. (pitanga, Genipa americana L. (jenipapo, Hancornia speciosa Gomes (mangaba, Mauritia flexuosa L.f. (buriti, Myrciaria cauliflora (DC Berg (jabuticaba, Psidium guajava L. (goiaba, Psidium spp. (araçá, Solanum lycocarpum St. Hill (lobeira, Spondias mombin L. (cajá, Annona crassiflora Mart. (araticum, among others are reported here.

  3. Human radiation studies: Remembering the early years: Oral history of health physicist Karl Z. Morgan, Ph.D., conducted January 7, 1995

    International Nuclear Information System (INIS)

    1995-06-01

    This report provided a transcript of an interview of Dr. Karl. Z. Morgan by representatives of the DOE Office of Human Radiation Experiments. Dr. Morgan was selected for this interview because of his research for the Manhattan Project at the Metallurgical Laboratory in Chicago and his work at the Oak Ridge National Laboratory (ORNL). The oral history covers Dr. Morgan's work as a pioneer in the field of Health Physics, his research at ORNL and his work since he retired from ORNL

  4. History Matters

    Institute of Scientific and Technical Information of China (English)

    2017-01-01

    In 2002, she began working as alecturer at Minzu University of China.Now, she teaches English, historicalliterature, ancient Chinese history,historical theory and method, ancientsocial history of China, ancient palacepolitical history of China and the historyof the Sui and Tang dynasties and thePeriod of Five Dynasties.

  5. Radioactive substances found on the contaminated fish

    Energy Technology Data Exchange (ETDEWEB)

    Kiba, T; Ohashi, S; Shibata, M; Mizube, T

    1954-01-01

    Radiochemical investigation of the substance collected from the surface of tuna fish which were brought back by the No. 5 Fukuryu Maru was performed. Most of the radioactivity was found on the scales which could not be decontaminated by treating with H/sub 2/O; 80% of the activity was removed by washing the dried scales with 3N HCl. Paper chromatographic separation of the HCl fraction showed the presence of /sup 140/Ba, /sup 89/Sr, /sup 132/Te, and probably /sup 95/Zr, /sup 140/La, and rare earths.

  6. The Morphological Analysis Found in Tempo Magazine

    OpenAIRE

    Lubis, Khairunnisa

    2015-01-01

    A paper entitled “The Morphological Analysis Found in Tempo Magazine” discussed about affixation process that is one of field linguistics, Morphology. The data of this research is five articles in Tempo magazine 1405/September 23-29, 2013. The scope of this writing is to find some kinds of prefixes and suffixes are used in Tempo magazine and to find what the dominant affix is. The method of research applied is descriptive qualitative. After analyzing the data, there are 5 kinds of prefixes, n...

  7. A History of Medicine and the Establishment of Medical Institutions in Middlesex County, New Jersey that Transformed Doctor and Patient Relationships during the Early Twentieth Century

    Science.gov (United States)

    Whitfield-Spinner, Linda

    2011-01-01

    The early twentieth century was a period of tremendous advancements in medicine and technology and as a result experienced a revolutionary change in the delivery of healthcare in America. Modern medicine which encompassed specialized knowledge, technical procedures, and rules of behavior, changed the way medical care was provided in the United…

  8. Histories electromagnetism

    International Nuclear Information System (INIS)

    Burch, Aidan

    2004-01-01

    Working within the HPO (History Projection Operator) Consistent Histories formalism, we follow the work of Savvidou on (scalar) field theory [J. Math. Phys. 43, 3053 (2002)] and that of Savvidou and Anastopoulos on (first-class) constrained systems [Class. Quantum Gravt. 17, 2463 (2000)] to write a histories theory (both classical and quantum) of Electromagnetism. We focus particularly on the foliation-dependence of the histories phase space/Hilbert space and the action thereon of the two Poincare groups that arise in histories field theory. We quantize in the spirit of the Dirac scheme for constrained systems

  9. Middleweight black holes found at last

    Science.gov (United States)

    Clery, Daniel

    2018-06-01

    How did giant black holes grow so big? Astronomers have long had evidence of baby black holes with masses of no more than tens of suns, and of million- or billion-solar-mass behemoths lurking at the centers of galaxies. But middle-size ones, weighing thousands or tens of thousands of suns, seemed to be missing. Their absence forced theorists to propose that supermassive black holes didn't grow gradually by slowly consuming matter, but somehow emerged as ready-made giants. Now, astronomers appear to have located some missing middleweights. An international team has scoured an archive of galaxy spectra and found more than 300 small galaxies that have the signature of intermediate mass black holes in their cores, opening new questions for theorists.

  10. Commentary on Malone: Who Founded Behaviorism?

    Science.gov (United States)

    Reese, Hayne W

    2015-05-01

    Malone (The Behavior Analyst, 37, 1-12 2014) argued that the emergence of behaviorism was inevitable with or without Watson's participation, mainly because protobehavioral ideas and dissatisfaction with classical structuralism were already widespread. However, the first premise is questionable because many of the ideas Malone cited were consistent with structuralism rather than behaviorism, and even if both premises were true they would not make the emergence of behaviorism-or anything else-inevitable. Historical evidence for inevitability is always retrospective and therefore always allows the logical fallacy of "after this, therefore because of this." In the relevant real world Watson existed, he was a psychologist, he was the first to publish an article that described a "behaviorism," and he promoted his behaviorism in later works. Stories about what would have happened without Watson's participation are therefore counterfactual and this lack of historicity makes the stories fictional rather than scientific. In the real world, Watson founded behaviorism.

  11. Human radiation studies: Remembering the early years: Oral history of radiation biologist Marvin Goldman, Ph.D., conducted December 22, 1994

    International Nuclear Information System (INIS)

    1995-09-01

    This report provides a transcript of an interview of Dr. Marvin Goldman by representatives of DOE's Office of Human Radiation Experiments. Dr. Goldman was chosen for this interview because of his work on bone-seeking radionuclides. After a brief biographical sketch Dr. Goldman related his experiences concerning his training and work at Rochester University, his work at Brookhaven National Laboratory, his participation in the Beagle Studies at University of California at Davis, his work with the Chernobyl Nuclear Plant Accident, his consultation work with Russian authorities on the health and ecological effects in their history, and finally his opinions and recommendations on human radiation research and the environmental cleanup of DOE sites

  12. Maternal lifetime history of depression and depressive symptoms in the prenatal and early postnatal period do not predict infant-mother attachment quality in a large, population-based Dutch cohort study.

    Science.gov (United States)

    Tharner, Anne; Luijk, Maartje P C M; van Ijzendoorn, Marinus H; Bakermans-Kranenburg, Marian J; Jaddoe, Vincent W V; Hofman, Albert; Verhulst, Frank C; Tiemeier, Henning

    2012-01-01

    We examined the effects of maternal history of depressive disorder and the effects of depressive symptoms during pregnancy and the early postpartum period on attachment insecurity and disorganization. A total of 627 mother-infant dyads from the Generation R Study participated in a population-based cohort from fetal life onwards. Maternal history of depression was assessed by diagnostic interviews during pregnancy; maternal peri- and postnatal depressive symptoms were assessed with questionnaires in 506 of these women at 20 weeks pregnancy and two months postpartum; and infant-mother attachment security was observed when infants were aged 14 months. A history of maternal depressive disorder, regardless of severity or psychiatric comorbidity, was not associated with an increased risk of infant attachment insecurity or disorganization. Likewise, maternal peri- and postnatal depressive symptoms were not related to attachment insecurity or disorganization at 14 months. These results are important because mothers from otherwise low risk backgrounds often have previously been depressed or are struggling with non-clinical depressive symptoms during pregnancy and after giving birth. Our findings are discussed in terms of protective factors that may limit the potentially negative effects of maternal depressive symptoms on the infant-mother attachment relationship in the general population. The role of selective attrition and lack of information about the mothers' attachment status for the current null-findings are also discussed.

  13. Mitigating Settlement of Structures founded on Peat

    Science.gov (United States)

    Wijeyesekera, D. C.; Numbikannu, L.; Ismail, T. N. H. T.; Bakar, I.

    2016-07-01

    Observations made of two common failures of structures founded on peat/organic soil in Johor, Malaysia is presented. Critical evaluation of current lightweight fill technology to mitigate such settlement is also discussed. Lightweight technology, such as Expanded Polystyrene (EPS), has been used in construction on soft yielding ground for decades. Regrettably, some published information of EPS failures to perform on construction sites are also cited in this paper. This paper outlines some concepts leading to the development of an alternative innovative lightweight fill is that the idealised cellular structure of the GCM permit free flow of water and complemented by the mat structure which evens out any differential settlement A further highlight of this paper is the monitoring of the field performance of this lightweight fill (GCM) as a feasible alternative to fill weight reduction on yielding ground.. Hence, a prime research objective was to compare the fill settlements observed with 1m high fill of surcharge loading on peat ground (comparison of the case of using a partial 0.6m high GCM and that of a total of 1m of conventional sand backfill).

  14. Arago Seamount: The missing hotspot found in the Austral Islands

    Science.gov (United States)

    Bonneville, Alain; Le Suavé, Raymond; Audin, Laurence; Clouard, Valérie; Dosso, Laure; Yves Gillot, Pierre; Janney, Philip; Jordahl, Kelsey; Maamaatuaiahutapu, Keitapu

    2002-11-01

    The Austral archipelago, on the western side of the South Pacific superswell, is composed of several volcanic chains, corresponding to distinct events from 35 Ma to the present, and lies on oceanic crust created between 60 and 85 Ma. In 1982, Turner and Jarrard proposed that the two distinct volcanic stages found on Rurutu Island and dated as 12 Ma and 1 Ma could be due to two different hotspots, but no evidence of any recent aerial or submarine volcanic source has ever been found. In July 1999, expedition ZEPOLYF2 aboard the R/V L'Atalante conducted a geophysical survey of the northern part of the Austral volcanic archipelago. Thirty seamounts were mapped for the first time, including a very shallow one (French Navy ship that discovered its summit in 1993, is the missing hotspot in the Cook-Austral history. This interpretation adds a new hotspot to the already complicated geologic history of this region. We suggest that several hotspots have been active simultaneously on a region of the seafloor that does not exceed 2000 km in diameter and that each of them had a short lifetime (<20 m.y.). These short-lived and closely spaced hotspots cannot be the result of discrete deep-mantle plumes and are likely due to more local upwelling in the upper mantle strongly influenced by weaknesses in the lithosphere.

  15. Comparison of Pilot Medical History and Medications Found In Postmortem Specimens

    National Research Council Canada - National Science Library

    Canfield, Dennis V; Salazar, Guillermo J; Lewis, Russell J; Whinnery, James E

    2006-01-01

    Pilots are required by FAA regulations to report all medications and medical conditions to the FAA Office of Aerospace Medicine for review as to the overall suitability of the pilot for flight activities...

  16. Orphan Stars Found in Long Galaxy Tail

    Science.gov (United States)

    2007-09-01

    Astronomers have found evidence that stars have been forming in a long tail of gas that extends well outside its parent galaxy. This discovery suggests that such "orphan" stars may be much more prevalent than previously thought. The comet-like tail was observed in X-ray light with NASA's Chandra X-ray Observatory and in optical light with the Southern Astrophysical Research (SOAR) telescope in Chile. The feature extends for more than 200,000 light years and was created as gas was stripped from a galaxy called ESO 137-001 that is plunging toward the center of Abell 3627, a giant cluster of galaxies. "This is one of the longest tails like this we have ever seen," said Ming Sun of Michigan State University, who led the study. "And, it turns out that this is a giant wake of creation, not of destruction." Chandra X-ray Image of ESO 137-001 and Tail in Abell 3627 Chandra X-ray Image of ESO 137-001 and Tail in Abell 3627 The observations indicate that the gas in the tail has formed millions of stars. Because the large amounts of gas and dust needed to form stars are typically found only within galaxies, astronomers have previously thought it unlikely that large numbers of stars would form outside a galaxy. "This isn't the first time that stars have been seen to form between galaxies," said team member Megan Donahue, also of MSU. "But the number of stars forming here is unprecedented." The evidence for star formation in this tail includes 29 regions of ionized hydrogen glowing in optical light, thought to be from newly formed stars. These regions are all downstream of the galaxy, located in or near the tail. Two Chandra X-ray sources are near these regions, another indication of star formation activity. The researchers believe the orphan stars formed within the last 10 million years or so. The stars in the tail of this fast-moving galaxy, which is some 220 million light years away, would be much more isolated than the vast majority of stars in galaxies. H-alpha Image of

  17. Blending Words Found In Social Media

    Directory of Open Access Journals (Sweden)

    Giyatmi Giyatmi

    2017-12-01

    Full Text Available There are many new words from the social media such as Netizen, Trentop, and Delcon. Those words include in blending. Blending is one of word formations combining two clipped words to form a brand new word. The researchers are interested in analyzing blend words used in the social media such as Instagram, Twitter, Facebook, and Blackberry Messenger. This research aims at (1 finding blend words used in the social media (2 describing kinds of blend words used in social media (3 describing the process of blend word formation used in the social media. This research uses some theories dealing with definition of blending and kinds of blending. This research belongs to descriptive qualitative research. Data of the research are English blend words used in social media. Data sources of this research are websites consisting of some English words used in social media and some social media users as the informant. Techniques of data collecting in this research are observation and simak catat. Observation is by observing some websites consisting of some English words used in social media. Simak catat is done by taking some notes on the data and encoding in symbols such as No/Blend words/Kinds of Blending. The researchers use source triangulation to check the data from the researchers with the informant and theory triangulation to determine kinds of blending and blend word formation in social media. There are115 data of blend words. Those data consists of 65 data of Instagram, 47 data of Twitter, 1 datum of Facebook, and 2 data of Blackberry Messenger. There are 2 types of blending used in social media;108 data of blending with clipping and 7 data of blending with overlapping. There are 10 ways of blend word formation found in this research.

  18. Early nucleoside reverse transcriptase inhibitors for the treatment of HIV: a brief history of stavudine (D4T) and its comparison with other dideoxynucleosides.

    Science.gov (United States)

    Martin, John C; Hitchcock, Michael J M; De Clercq, Erik; Prusoff, William H

    2010-01-01

    The occasion of this 25th anniversary issue encouraged us to reminisce about the important history of the discovery of the dideoxynucleoside analogues for the treatment of HIV/AIDS and to chronicle our thoughts about a particular exciting and rewarding period of our scientific careers. Following the identification of the anti-HIV activity of zidovudine (AZT), we participated in the urgent quest to discover optimal treatments of HIV infection and AIDS. A number of previously synthesized nucleoside analogues were comparatively evaluated, and stavudine (D4T) emerged as a promising candidate for development. Following clinical evaluation, D4T became a mainstay of the initial antiretroviral combination therapy, prolonging and saving numerous lives. It has only recently been supplanted by better-tolerated treatments. This article forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development, vol. 85, issue 1, 2010. Copyright 2009 Elsevier B.V. All rights reserved.

  19. Entangled histories

    International Nuclear Information System (INIS)

    Cotler, Jordan; Wilczek, Frank

    2016-01-01

    We introduce quantum history states and their mathematical framework, thereby reinterpreting and extending the consistent histories approach to quantum theory. Through thought experiments, we demonstrate that our formalism allows us to analyze a quantum version of history in which we reconstruct the past by observations. In particular, we can pass from measurements to inferences about ‘what happened’ in a way that is sensible and free of paradox. Our framework allows for a richer understanding of the temporal structure of quantum theory, and we construct history states that embody peculiar, non-classical correlations in time. (paper)

  20. A craniometric analysis of early modern Romania and Hungary: The roles of migration and conversion in shaping European Ottoman population history.

    Science.gov (United States)

    Allen, Kathryn Grow; von Cramon-Taubadel, Noreen

    2017-11-01

    Debate persists regarding the biological makeup of European Ottoman communities settled during the expansion of the Ottoman Empire during the 16th and 17th centuries, and the roles of conversion and migration in shaping demography and population history. The aim of this study was to perform an assessment of the biological affinities of three European Ottoman series based on craniometric data. Craniometric data collected from three Ottoman series from Hungary and Romania were compared to European and Anatolian comparative series, selected to represent biological affinity representative of historically recorded migration and conversion influences. Sex-separated samples were analyzed using D 2 -matrices, along with principal coordinates and PERMANOVA analyses to investigate biological affinities. Discriminant function analysis was employed to assign Ottoman individuals to two potential classes: European or Anatolian. Affinity analyses show larger than expected biological differences between males and females within each of the Ottoman communities. Discriminant function analyses show that the majority of Ottoman individuals could be classified as either European or Anatolian with a high probability. Moreover, location within Europe proved influential, as the Ottomans from a location of more geopolitical importance (Budapest) diverged from more hinterland communities in terms of biological affinity patterns. The results suggest that male and female Ottomans may possess distinct population histories, with males and females divergent from each other in terms of their biological affinities. The Ottoman communities appear diverse in terms of constituting a mix of peoples from different biological backgrounds. The greater distances between sexes from the same community, and the differences between communities, may be evidence that the processes of migration and conversion impacted individual people and groups diversely. © 2017 Wiley Periodicals, Inc.

  1. Standard metabolic rates of early life stages of the diamondback terrapin (Malaclemys terrapin), an estuarine turtle, suggest correlates between life history changes and the metabolic economy of hatchlings.

    Science.gov (United States)

    Rowe, Christopher L

    2018-04-01

    I estimated standard metabolic rates (SMR) using measurements of oxygen consumption rates of embryos and unfed, resting hatchlings of the diamondback terrapin (Malaclemys terrapin) three times during embryonic development and twice during the early post-hatching period. The highest observed SMRs occurred during mid to late embryonic development and the early post-hatching period when hatchlings were still reliant on yolk reserves provided by the mother. Hatchlings that were reliant on yolk displayed per capita SMR 135 % higher than when measured 25 calendar days later after they became reliant on exogenous resources. The magnitude of the difference in hatchling SMR between yolk-reliant and exogenously feeding stages was much greater than that attributed to costs of digestion (specific dynamic action) observed in another emydid turtle, suggesting that processing of the yolk was not solely responsible for the observed difference. The pre-feeding period of yolk reliance of hatchlings corresponds with the period of dispersal from the nesting site, suggesting that elevated SMR during this period could facilitate dispersal activities. Thus, I hypothesize that the reduction in SMR after the development of feeding behaviors may reflect an energy optimization strategy in which a high metabolic expenditure in support of development and growth of the embryo and dispersal of the hatchling is followed by a substantial reduction in metabolic expenditure coincident with the individual becoming reliant on exogenous resources following yolk depletion. Copyright © 2018 Elsevier GmbH. All rights reserved.

  2. Intellectual History

    DEFF Research Database (Denmark)

    In the 5 Questions book series, this volume presents a range of leading scholars in Intellectual History and the History of Ideas through their answers to a brief questionnaire. Respondents include Michael Friedman, Jacques le Goff, Hans Ulrich Gumbrecht, Jonathan Israel, Phiip Pettit, John Pocock...

  3. Sea Level History in 3D: Early results of an ultra-high resolution MCS survey across IODP Expedition 313 drillsites

    Science.gov (United States)

    Mountain, G. S.; Kucuk, H. M.; Nedimovic, M. R.; Austin, J. A., Jr.; Fulthorpe, C.; Newton, A.; Baldwin, K.; Johnson, C.; Stanley, J. N.; Bhatnagar, T.

    2015-12-01

    Although globally averaged sea level is rising at roughly 3 mm/yr (and is accelerating), rates of local sea-level change measured at coastlines may differ from this number by a factor of two or more; at some locations, sea level may even be falling. This is due to local processes that can match or even reverse the global trend, making it clear that reliable predictions of future impacts of sea-level rise require a firm understanding of processes at the local level. The history of local sea-level change and shoreline response is contained in the geologic record of shallow-water sediments. We report on a continuing study of sea-level history in sediments at the New Jersey continental margin, where compaction and glacial isostatic adjustment are currently adding 2 mm/yr to the globally averaged rise. We collected 570 sq km of ultra-high resolution 3D MCS data aboard the R/V Langseth in June-July 2015; innovative recording and preliminary results are described by Nedimovic et al. in this same session. The goal was to provide regional context to coring and logging at IODP Exp 313 sites 27-29 that were drilled 750 m into the New Jersey shelf in 2009. These sites recovered a nearly continuous record of post-Eocene sediments from non-marine soils, estuaries, shoreface, delta front, pro-delta and open marine settings. Existing seismic data are good but are 2D high-resolution profiles at line spacings too wide to enable mapping of key nearshore features. The Langseth 3D survey used shallow towing of a tuned air gun array to preserve high frequencies, and twenty-four 50-m PCables each 12.5 apart provided 6.25 x 3.125 m common-midpoint bins along seventy-seven 50-km sail lines. With this especially dense spatial resolution of a pre-stack time migrated volume we expect to map rivers, incised valleys, barrier islands, inlets and bays, pro-delta clinoforms, tidal deltas, sequence boundaries, debris flow aprons, and more. Seismic attributes linked to sedimentary facies and

  4. Human radiation studies: Remembering the early years: Oral history of cell biologist Don Francis Petersen, Ph.D., conducted November 29, 1994

    International Nuclear Information System (INIS)

    1995-08-01

    This report is a transcript of an interview of Dr. Don Francis Petersen by representatives of the US DOE Office of Human Radiation Experiments. Dr. Petersen was selected for this interview because of his long research career at Los Alamos and his knowledge of the Atomic Energy Commission's biomedical program. Dr. Petersen did not personally conduct research on human subjects. After a brief biographical sketch Dr. Petersen discusses his remembrances of the early use of radionuclides as biological tracers, aspects of nuclear weapons testing in the 1940's and 1950's including fallout studies, the means by which research projects were approved, use of humans in the whole-body counter, and the Health Division Biomedical responsibilities

  5. Human radiation studies: Remembering the early years: Oral history of cell biologist Don Francis Petersen, Ph.D., conducted November 29, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    This report is a transcript of an interview of Dr. Don Francis Petersen by representatives of the US DOE Office of Human Radiation Experiments. Dr. Petersen was selected for this interview because of his long research career at Los Alamos and his knowledge of the Atomic Energy Commission`s biomedical program. Dr. Petersen did not personally conduct research on human subjects. After a brief biographical sketch Dr. Petersen discusses his remembrances of the early use of radionuclides as biological tracers, aspects of nuclear weapons testing in the 1940`s and 1950`s including fallout studies, the means by which research projects were approved, use of humans in the whole-body counter, and the Health Division Biomedical responsibilities.

  6. Origins and Early History of Underwater Neutral Buoyancy Simulation of Weightlessness for EVA Procedures Development and Training. Part 2; Winnowing and Regrowth

    Science.gov (United States)

    Charles, John B.

    2013-01-01

    The technique of neutral buoyancy during water immersion was applied to a variety of questions pertaining to human performance factors in the early years of the space age. It was independently initiated by numerous aerospace contractors at nearly the same time, but specific applications depended on the problems that the developers were trying to solve. Those problems dealt primarily with human restraint and maneuverability and were often generic across extravehicular activity (EVA) and intravehicular activity (IVA) worksites. The same groups often also considered fractional gravity as well as weightless settings and experimented with ballasting to achieve lunar and Mars-equivalent loads as part of their on-going research and development. Dr. John Charles reviewed the association of those tasks with contemporary perceptions of the direction of NASA's future space exploration activities and with Air Force assessments of the military value of man in space.

  7. Human radiation studies: Remembering the early years: Oral history of radiologist Hymer L. Friedell, M.D., Ph.D., conducted January 28, 1995

    International Nuclear Information System (INIS)

    Fisher, D.; Melamed, E.

    1995-07-01

    NThis report is a transcript of an interview with Hymer L. Friedell by representatives of the US DOE Office of Human Radiation Experiments. Dr. Friedell was selected for this interview because of his participation in the early stages of the medical use of radioisotopes, his important role in the Manhattan Engineer District Medical Division, and his distinguished medical career and his involvement in the distribution of isotopes and the approval for their use in humans. After a brief biographical sketch Dr. Friedell discusses his remembrances on a wide range of subjects. Topics discussed include pre-war radiation therapy, information provided to patients, the Army Medical Corps and the Manhattan Project, his work at the Chicago Metallurgical Laboratory, inspection visits of Manhattan Project facilities and proposed sites, Plutonium injection studies, and actions of the AEC Isotope Distribution Committee

  8. Early upper paleolithic shell beads at Üçağızlı Cave I (Turkey): technology and the socioeconomic context of ornament life-histories.

    Science.gov (United States)

    Stiner, Mary C; Kuhn, Steven L; Güleç, Erksin

    2013-05-01

    Ten early Upper Paleolithic layers in Üçağızlı Cave I (41-29 uncalibrated ky BP) on the Hatay coast of southern Turkey preserve a rich and varied record of early Upper Paleolithic life, including the production and use of large numbers of shell ornaments. This study examines shell bead production, use, and discard in relation to site function and the diversity of on-site human activities. Four factors are expected to contribute to variation in the ornament assemblages, one environmental and three behavioral. The behavioral factors relate to winnowing for quality as a function of distance from the raw material source, changes in the size of user groups, and symbol standardization. The accumulation rates for shell beads, bones, and stone tools paralleled one another through time, indicating that ornament discard followed the pulse of daily life at this site. All stages of manufacture and use are well represented in each assemblage, and half or more of the ornaments show evidence of extended use. Changes in the local marine environment do not explain much of the variation in the assemblages, pointing instead to behavioral causes. The richness of shell types that were collected as raw material correlates to greater exploitation of edible marine shellfish and greater occupation intensity. Much of this variation in the ornament raw material was eliminated during the manufacture stage, almost certainly reflecting the influence of cultural norms. A focus on basket-shaped shells changed remarkably little over thousands of years, despite significant changes in other domains of technology. This last result suggests that beads were the most irreducible and conservative elements of more complex design traditions. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. FORMATION EPOCHS, STAR FORMATION HISTORIES, AND SIZES OF MASSIVE EARLY-TYPE GALAXIES IN CLUSTER AND FIELD ENVIRONMENTS AT z = 1.2: INSIGHTS FROM THE REST-FRAME ULTRAVIOLET

    International Nuclear Information System (INIS)

    Rettura, Alessandro; Demarco, R.; Ford, H. C.; Rosati, P.; Gobat, R.; Nonino, M.; Fosbury, R. A. E.; Menci, N.; Strazzullo, V.; Mei, S.

    2010-01-01

    We derive stellar masses, ages, and star formation histories (SFHs) of massive early-type galaxies in the z = 1.237 RDCS1252.9-2927 cluster and compare them with those measured in a similarly mass-selected sample of field contemporaries drawn from the Great Observatories Origin Deep Survey South Field. Robust estimates of these parameters are obtained by comparing a large grid of composite stellar population models with 8-9 band photometry in the rest-frame near-ultraviolet, optical, and IR, thus sampling the entire relevant domain of emission of the different stellar populations. Additionally, we present new, deep U-band photometry of both fields, giving access to the critical far-ultraviolet rest frame, in order to empirically constrain the dependence of the most recent star formation processes on the environment. We also analyze the morphological properties of both samples to examine the dependence of their scaling relations on their mass and environment. We find that early-type galaxies, both in the cluster and in the field, show analogous optical morphologies, follow comparable mass versus size relation, have congruent average surface stellar mass densities, and lie on the same Kormendy relation. We also show that a fraction of early-type galaxies in the field employ longer timescales, τ, to assemble their mass than their cluster contemporaries. Hence, we conclude that while the formation epoch of early-type galaxies only depends on their mass, the environment does regulate the timescales of their SFHs. Our deep U-band imaging strongly supports this conclusion. We show that cluster galaxies are at least 0.5 mag fainter than their field contemporaries of similar mass and optical-to-infrared colors, implying that the last episode of star formation must have happened more recently in the field than in the cluster.

  10. IMPACT OF HATCH-DATE ON EARLY LIFE GROWTH AND SURVIVAL OF MUELLER’S PEARLSIDE (MAUROLICUS MUELLERI) LARVAE, AND LIFE-HISTORY CONSEQUENCES

    KAUST Repository

    Folkvord, Arild

    2015-08-11

    Growth and survival of Maurolicus muelleri larvae in Herdlefjorden, Norway were investigated by daily otolith increment analysis. While high egg densities were generally observed throughout the spawning season, three cohorts each with a narrow window of hatching dates were identified. The first of these cohorts was characterized by low growth and poor morphometric condition and disappeared from the fjord during autumn. High resolution drift modeling indicated that Herdlefjorden had a net export of larvae and negligible import in the period cohort 1 disappeared. Yet, the advective loss rate of larvae was not considered high enough to explain the near complete disappearance of the first cohort. An otolith based growth chronology indicated that growth conditions in Herdlefjorden improved noticeably around mid-September, and remained favorable the following month. The analysis of daily otolith increments could thus be used to document within-season variability in larval growth and survival. The low and variable survival due to short term fluctuations in environmental conditions indicate that multiple batch spawning is an adequately evolved life history strategy for marine planktivorous fish such as M. muelleri.

  11. The Interaction of Risk Network Structures and Virus Natural History in the Non-spreading of HIV Among People Who Inject Drugs in the Early Stages of the Epidemic.

    Science.gov (United States)

    Dombrowski, Kirk; Khan, Bilal; Habecker, Patrick; Hagan, Holly; Friedman, Samuel R; Saad, Mohamed

    2017-04-01

    This article explores how social network dynamics may have reduced the spread of HIV-1 infection among people who inject drugs during the early years of the epidemic. Stochastic, discrete event, agent-based simulations are used to test whether a "firewall effect" can arise out of self-organizing processes at the actor level, and whether such an effect can account for stable HIV prevalence rates below population saturation. Repeated simulation experiments show that, in the presence of recurring, acute, and highly infectious outbreaks, micro-network structures combine with the HIV virus's natural history to reduce the spread of the disease. These results indicate that network factors likely played a significant role in the prevention of HIV infection within injection risk networks during periods of peak prevalence. They also suggest that social forces that disturb network connections may diminish the natural firewall effect and result in higher rates of HIV.

  12. Soul, mind and brain in pre-history and early human civilizations / Alma, mente e cérebro na pré-história e nas primeiras civilizações humanas

    Directory of Open Access Journals (Sweden)

    Fabiano dos Santos Castro

    2010-01-01

    Full Text Available Currently, the debate about the nature of the human mind is taking new directions through the development of several studies in the field of neuroscience which investigates the location of brain functions. These studies have contributed to a better understanding of the neural substrates of mental functions and the etiology of various mental disorders. However, the knowledge developed by neuroscience did not occur abruptly. Indeed, the study of mind-brain relationship is not new. From pre-history to the present days, various different types of inquiries have been made about the possible materiality and location of human mental functions. This paper presents, in a historic manner, how prehistoric populations as well as early civilizations located in Egypt, Mesopotamia, India, and China developed and employed concepts related to the soul, the mind and the human brain.

  13. The ACS LCID project. IX. Imprints of the early universe in the radial variation of the star formation history of dwarf galaxies

    International Nuclear Information System (INIS)

    Hidalgo, Sebastian L.; Monelli, Matteo; Aparicio, Antonio; Gallart, Carme

    2013-01-01

    Based on Hubble Space Telescope observations from the Local Cosmology from Isolated Dwarfs project, we present the star formation histories, as a function of galactocentric radius, of four isolated Local Group dwarf galaxies: two dSph galaxies, Cetus and Tucana, and two transition galaxies (dTrs), LGS-3 and Phoenix. The oldest stellar populations of the dSphs and dTrs are, within the uncertainties, coeval (∼13 Gyr) at all galactocentric radii. We find that there are no significative differences between the four galaxies in the fundamental properties (such as the normalized star formation rate or age-metallicity relation) of their outer regions (radii greater than four exponential scale lengths); at large radii, these galaxies consist exclusively of old (≳ 10.5 Gyr) metal-poor stars. The duration of star formation in the inner regions varies from galaxy to galaxy, and the extended central star formation in the dTrs produces the dichotomy between dSph and dTr galaxy types. The dTr galaxies show prominent radial stellar population gradients: The centers of these galaxies host young (≲ 1 Gyr) populations, while the age of the last formation event increases smoothly with increasing radius. This contrasts with the two dSph galaxies. Tucana shows a similar, but milder, gradient, but no gradient in age is detected Cetus. For the three galaxies with significant stellar population gradients, the exponential scale length decreases with time. These results are in agreement with outside-in scenarios of dwarf galaxy evolution, in which a quenching of the star formation toward the center occurs as the galaxy runs out of gas in the outskirts.

  14. Plio-Pleistocene history and phylogeography of Acacia senegal in dry woodlands and savannahs of sub-Saharan tropical Africa: evidence of early colonisation and recent range expansion.

    Science.gov (United States)

    Odee, D W; Telford, A; Wilson, J; Gaye, A; Cavers, S

    2012-12-01

    Drylands are extensive across sub-Saharan Africa, socio-economically and ecologically important yet highly sensitive to environmental changes. Evolutionary history, as revealed by contemporary intraspecific genetic variation, can provide valuable insight into how species have responded to past environmental and population changes and guide strategies to promote resilience to future changes. The gum arabic tree (Acacia senegal) is an arid-adapted, morphologically diverse species native to the sub-Saharan drylands. We used variation in nuclear sequences (internal transcribed spacer (ITS)) and two types of chloroplast DNA (cpDNA) markers (PCR-RFLP, cpSSR) to study the phylogeography of the species with 293 individuals from 66 populations sampled across its natural range. cpDNA data showed high regional and rangewide haplotypic diversity (h(T(cpSSR))=0.903-0.948) and population differentiation (G(ST(RFLP))=0.700-0.782) with a phylogeographic pattern that indicated extensive historical gene flow via seed dispersal. Haplotypes were not restricted to any of the four varieties, but showed significant geographic structure (G(ST(cpSSR))=0.392; R(ST)=0.673; R(ST)>R(ST) (permuted)), with the major division separating East and Southern Africa populations from those in West and Central Africa. Phylogenetic analysis of ITS data indicated a more recent origin for the clade including West and Central African haplotypes, suggesting range expansion in this region, possibly during the Holocene humid period. In conjunction with paleobotanical evidence, our data suggest dispersal to West Africa, and across to the Arabian Peninsula and Indian subcontinent, from source populations located in the East African region during climate oscillations of the Plio-Pleistocene.

  15. Plio-Pleistocene history and phylogeography of Acacia senegal in dry woodlands and savannahs of sub-Saharan tropical Africa: evidence of early colonisation and recent range expansion

    Science.gov (United States)

    Odee, D W; Telford, A; Wilson, J; Gaye, A; Cavers, S

    2012-01-01

    Drylands are extensive across sub-Saharan Africa, socio-economically and ecologically important yet highly sensitive to environmental changes. Evolutionary history, as revealed by contemporary intraspecific genetic variation, can provide valuable insight into how species have responded to past environmental and population changes and guide strategies to promote resilience to future changes. The gum arabic tree (Acacia senegal) is an arid-adapted, morphologically diverse species native to the sub-Saharan drylands. We used variation in nuclear sequences (internal transcribed spacer (ITS)) and two types of chloroplast DNA (cpDNA) markers (PCR-RFLP, cpSSR) to study the phylogeography of the species with 293 individuals from 66 populations sampled across its natural range. cpDNA data showed high regional and rangewide haplotypic diversity (hT(cpSSR)=0.903–0.948) and population differentiation (GST(RFLP)=0.700–0.782) with a phylogeographic pattern that indicated extensive historical gene flow via seed dispersal. Haplotypes were not restricted to any of the four varieties, but showed significant geographic structure (GST(cpSSR)=0.392; RST=0.673; RST>RST (permuted)), with the major division separating East and Southern Africa populations from those in West and Central Africa. Phylogenetic analysis of ITS data indicated a more recent origin for the clade including West and Central African haplotypes, suggesting range expansion in this region, possibly during the Holocene humid period. In conjunction with paleobotanical evidence, our data suggest dispersal to West Africa, and across to the Arabian Peninsula and Indian subcontinent, from source populations located in the East African region during climate oscillations of the Plio-Pleistocene. PMID:22929152

  16. The ACS LCID project. IX. Imprints of the early universe in the radial variation of the star formation history of dwarf galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Hidalgo, Sebastian L.; Monelli, Matteo; Aparicio, Antonio; Gallart, Carme, E-mail: shidalgo@iac.es, E-mail: monelli@iac.es, E-mail: aparicio@iac.es, E-mail: carme@iac.es [Instituto de Astrofísica de Canarias, Vía Láctea s/n, E-38200 La Laguna, Tenerife, Canary Islands (Spain); and others

    2013-12-01

    Based on Hubble Space Telescope observations from the Local Cosmology from Isolated Dwarfs project, we present the star formation histories, as a function of galactocentric radius, of four isolated Local Group dwarf galaxies: two dSph galaxies, Cetus and Tucana, and two transition galaxies (dTrs), LGS-3 and Phoenix. The oldest stellar populations of the dSphs and dTrs are, within the uncertainties, coeval (∼13 Gyr) at all galactocentric radii. We find that there are no significative differences between the four galaxies in the fundamental properties (such as the normalized star formation rate or age-metallicity relation) of their outer regions (radii greater than four exponential scale lengths); at large radii, these galaxies consist exclusively of old (≳ 10.5 Gyr) metal-poor stars. The duration of star formation in the inner regions varies from galaxy to galaxy, and the extended central star formation in the dTrs produces the dichotomy between dSph and dTr galaxy types. The dTr galaxies show prominent radial stellar population gradients: The centers of these galaxies host young (≲ 1 Gyr) populations, while the age of the last formation event increases smoothly with increasing radius. This contrasts with the two dSph galaxies. Tucana shows a similar, but milder, gradient, but no gradient in age is detected Cetus. For the three galaxies with significant stellar population gradients, the exponential scale length decreases with time. These results are in agreement with outside-in scenarios of dwarf galaxy evolution, in which a quenching of the star formation toward the center occurs as the galaxy runs out of gas in the outskirts.

  17. The history of human-induced soil erosion: Geomorphic legacies, early descriptions and research, and the development of soil conservation—A global synopsis

    Science.gov (United States)

    Dotterweich, Markus

    2013-11-01

    This paper presents a global synopsis about the geomorphic evidence of soil erosion in humid and semihumid areas since the beginning of agriculture. Historical documents, starting from ancient records to data from the mid-twentieth century and numerous literature reviews form an extensive assortment of examples that show how soil erosion has been perceived previously by scholars, land surveyors, farmers, land owners, researchers, and policy makers. Examples have been selected from ancient Greek and Roman Times and from central Europe, southern Africa, North America, the Chinese Loess Plateau, Australia, New Zealand, and Easter Island. Furthermore, a comprehensive collection on the development of soil erosion research and soil conservation has been provided, with a particular focus on Germany and the USA. Geomorphic evidence shows that most of the agriculturally used slopes in the Old and New Worlds had already been affected by soil erosion in earlier, prehistoric times. Early descriptions of soil erosion are often very vague. With regard to the Roman Times, geomorphic evidence shows seemingly opposing results, ranging from massive devastation to landscapes remaining stable for centuries. Unfortunately, historical documentation is lacking. In the following centuries, historical records become more frequent and more precise and observations on extreme soil erosion events are prominent. Sometimes they can be clearly linked to geomorphic evidence in the field. The advent of professional soil conservation took place in the late eighteenth century. The first extensive essay on soil conservation known to the Western world was published in Germany in 1815. The rise of professional soil conservation occurred in the late nineteenth and early twentieth centuries. Soil remediation and flood prevention programs were initiated, but the long-term success of these actions remains controversial. In recent years, increasing interest is to recover any traditional knowledge of soil

  18. 3He/4He ratio, noble gas abundance and K-Ar dating of diamonds - an attempt to search for the records of early terrestrial history

    International Nuclear Information System (INIS)

    Ozima, M.; Zashu, S.; Nitoh, O.

    1983-01-01

    The 3 He/ 4 He ratios measured in 27 Southern Africa diamond stones, four from Premier Mine and the rest of unidentified origin, range from 4.2 x 10 -8 to 3.2 x 10 -4 , with three stones above 1 x 10 -4 . We conclude that the initial helium isotopic ratio ( 3 He/ 4 He) 0 in the earth was significantly higher than that of the planetary helium-A ( 3 He/ 4 He = 1.42 x 10 -4 ), but close to the solar helium ( 3 He/ 4 He = approx. 4 x 10 -4 ). The apparent K-Ar ages for the twelve diamonds of unidentified origin show enormously old age, indicating excess argon-40. 3 He/ 4 He evolution in diamonds suggests that the diamonds with the high 3 He/ 4 He ratio (> 2 x 10 -4 ) may be as old as the earth. Noble gas elemental abundance in the diamonds relative to the air noble gas abundance shows monotonic decrease with a decreasing mass number. This paper discusses the implications of these observations on the early solar system and the origin of diamonds. (author)

  19. Identification of a novel PSEN1 mutation (Leu232Pro) in a Korean patient with early-onset Alzheimer's disease and a family history of dementia.

    Science.gov (United States)

    Park, Jiyun; An, Seong Soo A; Giau, Vo Van; Shim, Kyuhwan; Youn, Young Chul; Bagyinszky, Eva; Kim, SangYun

    2017-08-01

    In the present study, a novel mutation in exon 7 of presenilin 1 (Leu232Pro) was discovered in a Korean patient with early-onset Alzheimer's disease, who represented memory decline at 37 years of age, followed by impairment in spatial activity and concentrations and personality changes. Imaging analyses with magnetic resonance scan showed diffuse atrophy in the frontoparietal regions. Targeted next generation sequencing and Sanger sequencing identified a heterozygous T to C transition at position 695 (c.695T>C) of in presenilin 1 gene (PSEN1), resulting in a novel missense mutation at codon 232 from leucine to proline (L232P). Several family members of the patient developed dementia, suggesting an autosomal dominant inheritance; however, we were unable to perform a segregation analysis to confirm this. Since the proline may play a role as a helix breaker, this mutation could significantly disturb the transmembrane helix domain-V of PSEN1 and perturb its protein functions. This hypothesis was supported by the results from the in silico analyses, predicted a major kink on this helix. Several leucine>proline substitutions in other PSEN1 transmembrane helices revealed aggressive AD phenotypes. Future functional studies would be needed to evaluate the pathogenicity of this mutation in AD. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Family History of Early Infant Death Correlates with Earlier Age at Diagnosis But Not Shorter Time to Diagnosis for Severe Combined Immunodeficiency

    Directory of Open Access Journals (Sweden)

    Anderson Dik Wai Luk

    2017-07-01

    Full Text Available BackgroundSevere combined immunodeficiency (SCID is fatal unless treated with hematopoietic stem cell transplant. Delay in diagnosis is common without newborn screening. Family history of infant death due to infection or known SCID (FH has been associated with earlier diagnosis.ObjectiveThe aim of this study was to identify the clinical features that affect age at diagnosis (AD and time to the diagnosis of SCID.MethodsFrom 2005 to 2016, 147 SCID patients were referred to the Asian Primary Immunodeficiency Network. Patients with genetic diagnosis, age at presentation (AP, and AD were selected for study.ResultsA total of 88 different SCID gene mutations were identified in 94 patients, including 49 IL2RG mutations, 12 RAG1 mutations, 8 RAG2 mutations, 7 JAK3 mutations, 4 DCLRE1C mutations, 4 IL7R mutations, 2 RFXANK mutations, and 2 ADA mutations. A total of 29 mutations were previously unreported. Eighty-three of the 94 patients fulfilled the selection criteria. Their median AD was 4 months, and the time to diagnosis was 2 months. The commonest SCID was X-linked (n = 57. A total of 29 patients had a positive FH. Candidiasis (n = 27 and bacillus Calmette–Guérin (BCG vaccine infection (n = 19 were the commonest infections. The median age for candidiasis and BCG infection documented were 3 months and 4 months, respectively. The median absolute lymphocyte count (ALC was 1.05 × 109/L with over 88% patients below 3 × 109/L. Positive FH was associated with earlier AP by 1 month (p = 0.002 and diagnosis by 2 months (p = 0.008, but not shorter time to diagnosis (p = 0.494. Candidiasis was associated with later AD by 2 months (p = 0.008 and longer time to diagnosis by 0.55 months (p = 0.003. BCG infections were not associated with age or time to diagnosis.ConclusionFH was useful to aid earlier diagnosis but was overlooked by clinicians and not by parents. Similarly, typical clinical features of

  1. Family History

    Science.gov (United States)

    Your family history includes health information about you and your close relatives. Families have many factors in common, including their genes, ... as heart disease, stroke, and cancer. Having a family member with a disease raises your risk, but ...

  2. Pregnancy in PCOS women and their history of diabetes

    DEFF Research Database (Denmark)

    Viftrup-Lund, Mette; Gade, Melina; Lauszus, Finn

    2014-01-01

    Objective: Evaluation of the incidence of gestational diabetes in PCOS women treated with metformin before and during early pregnancy and to ascertain their family history of diabetes. Design: Follow-up on all women with PCOS and infertility who received treatment with metformin prior to pregnancy...... (=index pregnancy) during 10 years. Data on diabetes was retrieved by questionnaire and hospital charts. Main outcome measures: Incidence of gestational diabetes, pregnancy outcome, and fetal size Results: In 18 % of the women GDM was diagnosed at some stage. The clinical and obstetrical outcome...... of the women showed no association with family history of diabetes or GDM. No neonatal anthropometric feature was different with respect to family history of diabetes or GDM and no fetal malformations were found Conclusion: GDM and family history of diabetes seem not to be associated with unfavourable...

  3. Life history strategy of the honey bee, Apis mellifera.

    Science.gov (United States)

    Seeley, Thomas D

    1978-01-01

    The feral honey bee queens (colonies) of central New York State (USA) show a K-type life history strategy. Their demographic characteristics include low early life mortality, low reproductive rate, long lifespan, high population stability and repeated reproductions. Identifying the life history strategy of these bees reveals the general pattern of selection for competitive ability, rather than productivity, which has shaped their societies. Selection for competitive power explains the adaptiveness (compared with alternatives found in many other insect societies) of the large perennial colonies, infrequent but expensive offspring, and efficient foraging which characterize the social organization of these bees.

  4. Cytogenetic and molecular genetic analysis of leukemias found in atomic bomb survivors

    International Nuclear Information System (INIS)

    Kamada, Nanao; Tanaka, Kimio; Eguchi, Mariko

    1994-01-01

    Seventy five radiation-related leukemia patients in Hiroshima including 16 patients exposed to more than one Gray were cytogenetically examined. Statistical analysis of data on the frequencies of chromosomal aberrations in the survivor groups according to bone marrow doses by DS86 estimation revealed that the heavily exposed group tended to have significantly higher aberration rates compared to the non-exposed group. Furthermore, the chromosomal aberrations in the survivors were observed to be of a more complex nature and had the characteristic findings of secondary leukemia. These observations therefore suggest that patients with a history of heavy exposure to atomic bomb radiation had leukemic cells originating from a stem cell which had been damaged by irradiation at the time of the bombing as well as cells involved in complex chromosome abnormalities. A higher incidence(p=0.06) of 11q23 abnormality was found in acute leukemia patients who had a history of exposure to A-bomb and developed from 1986 to 1993. However, we could not detect rearrangement of MLL gene in these patients. Break point region on 11q23 of radiation induced leukemias may be different from the common 8.5 kb region. Molecular biologic studies on RAS genes in acute and chronic leukemias and the BCR gene in chronic myelocytic leukemia were performed in exposed and non-exposed groups. So far, no distinctive differences have been observed in the frequency and sites of point mutations in N and K-RAS genes or in the rearrangement of the BCR gene. Further, retrospective analysis using DNA from leukemia patients who developed the disease in the early period from atomic bomb radiation exposure would be useful for elucidation of the mechanisms of radiation-induced leukemia. (author)

  5. A history of homosexuality and organized psychoanalysis.

    Science.gov (United States)

    Drescher, Jack

    2008-01-01

    Today the Academy of Psychoanalysis and Dynamic Psychiatry welcomes its gay and lesbian members. Yet at the time of its 1956 founding, organized psychoanalytic attitudes toward homosexuality could be reasonably characterized as hostile. First there was a transition from Freud's early views of homosexuality as immature to later neofreudian theories that pathologized same-sex attractions and behavior. Following the 1973 decision of the American Psychiatric Association to remove homosexuality from the DSM, homosexuality is now more commonly regarded as a normal variant of human sexuality. The history of psychoanalytic attitudes toward homosexuality reinforces the impression that psychoanalytic theories cannot be divorced from the political, cultural, and personal contexts in which they are formulated. This history also shows that analysts can take positions that either facilitate or obstruct tolerance and acceptance.

  6. Abortion: a history.

    Science.gov (United States)

    Hovey, G

    1985-01-01

    This review of abortion history considers sacred and secular practice and traces abortion in the US, the legacy of the 19th century, and the change that occurred in the 20th century. Abortion has been practiced since ancient times, but its legality and availability have been threatened continuously by forces that would denigrate women's fundamental rights. Currently, while efforts to decrease the need for abortion through contraception and education continue, access to abortion remains crucial for the well-being of millions of women. That access will never be secure until profound changes occur in the whole society. Laws that prohibit absolutely the practice of abortion are a relatively recent development. In the early Roman Catholic church, abortion was permitted for male fetuses in the first 40 days of pregnancy and for female fetuses in the first 80-90 days. Not until 1588 did Pope Sixtus V declare all abortion murder, with excommunication as the punishment. Only 3 years later a new pope found the absolute sanction unworkable and again allowed early abortions. 300 years would pass before the Catholic church under Pius IX again declared all abortion murder. This standard, declared in 1869, remains the official position of the church, reaffirmed by the current pope. In 1920 the Soviet Union became the 1st modern state formally to legalize abortion. In the early period after the 1917 revolution, abortion was readily available in state operated facilities. These facilities were closed and abortion made illegal when it became clear that the Soviet Union would have to defend itself against Nazi Germany. After World War II women were encouraged to enter the labor force, and abortion once again became legal. The cases of the Catholic church and the Soviet Union illustrate the same point. Abortion legislation has never been in the hands of women. In the 20th century, state policy has been determined by the rhythms of economic and military expansion, the desire for cheap

  7. Student Interviews Fifty Years Later: An Oral History

    OpenAIRE

    2018-01-01

    The Regional History Project at UC Santa Cruz has rich collections of interviews with generations of narrators, ranging across the administration, faculty, and staff. In the early years of the campus, founding director Elizabeth Spedding Calciano conducted two rounds of interviews focused on the student experience at what was then the newest campus of the University of California. Those interviews, conducted in 1967 and 1969 as the campus was still adding a new college every year, give a wind...

  8. Environmental history

    DEFF Research Database (Denmark)

    Pawson, Eric; Christensen, Andreas Aagaard

    2017-01-01

    Environmental history is an interdisciplinary pursuit that has developed as a form of conscience to counter an increasingly powerful, forward-looking liberal theory of the environment. It deals with the relations between environmental ideas and materialities, from the work of the geographers George...... risks”. These are exposed by environmental history’s focus on long-run analysis and its narrative form that identifies the stories that we tell ourselves about nature. How a better understanding of past environmental transformations helps to analyse society and agency, and what this can mean...... for solutions and policies, is the agenda for an engaged environmental history from now on....

  9. Ildens historier

    DEFF Research Database (Denmark)

    Lassen, Henrik Roesgaard

    have been written by Andersen. In several chapters the curiously forgotten history of fire-lighting technology is outlined, and it is demonstrated that "Tællelyset" is written by a person with a modern perspective on how to light a candle - among other things. The central argument in the book springs...... from a point-by-point tracing of 'the origins and history' of Hans Christian Andersen's famous fairy tales. Where did the come from? How did they become the iconic texts that we know today? On this background it becomes quite clear that "Tællelyset" is a modern pastiche and not a genuine Hans Christian...

  10. Business History

    DEFF Research Database (Denmark)

    Hansen, Per H.

    2012-01-01

    This article argues that a cultural and narrative perspective can enrich the business history field, encourage new and different questions and answers, and provide new ways of thinking about methods and empirical material. It discusses what culture is and how it relates to narratives. Taking...

  11. LCA History

    DEFF Research Database (Denmark)

    Bjørn, Anders; Owsianiak, Mikołaj; Molin, Christine

    2018-01-01

    The idea of LCA was conceived in the 1960s when environmental degradation and in particular the limited access to resources started becoming a concern. This chapter gives a brief summary of the history of LCA since then with a focus on the fields of methodological development, application...

  12. Rewriting History.

    Science.gov (United States)

    Ramirez, Catherine Clark

    1994-01-01

    Suggests that the telling of vivid stories can help engage elementary students' emotions and increase the chances of fostering an interest in Texas history. Suggests that incorporating elements of the process approach to writing can merge with social studies objectives in creating a curriculum for wisdom. (RS)

  13. Early and extraordinary peaks in physical performance come with a longevity cost

    DEFF Research Database (Denmark)

    van de Vijver, Paul L; van Bodegom, David; Westendorp, Rudi G J

    2016-01-01

    Life history theory postulates a trade-off between development and maintenance. This trade-off is observed when comparing life histories of different animal species. In humans, however, it is debated if variation in longevity is explained by differences in developmental traits. Observational...... studies found a trade-off between early and high fecundity and longevity in women. Development encompasses more than fecundity and also concerns growth and physical performance. Here, we show a life history trade-off between early and above average physical performance and longevity in male Olympic...... suffered a 4.7-year longevity cost. (95% CI 2.1-7.5 years, p=0.001). This is the first time a life history trade-off between physical performance and longevity has been found in humans. This finding deepens our understanding of early developmental influences on the variation of longevity in humans....

  14. [Is there a German history of evidence-based medicine? Methodic standards of therapeutic research in the early 20th century and Paul Martini's "Methodology of therapeutic investigation" (1932)].

    Science.gov (United States)

    Stoll, S; Roelcke, V; Raspe, H

    2005-07-29

    The article addresses the history of evidence-based medicine in Germany. Its aim was to reconstruct the standard of clinical-therapeutic investigation in Germany at the beginning of the 20 (th) century. By a historical investigation of five important German general medical journals for the time between 1918 and 1932 an overview of the situation of clinical investigation is given. 268 clinical trails are identified, and are analysed in view of their methodological design. Heterogeneous results are found: While few examples of sophisticated methodology exist, the design of the majority of the studies is poor. A response to the situation described can be seen in Paul Martini's book "Methodology of Therapeutic Investigation", first published in 1932. Paul Martini's biography, his criticism of the situation of clinical-therapeutic investigation of his time, the major points of his methodology and the reception of the book in Germany and abroad are described.

  15. History of the seronegative spondyloarthropathies

    International Nuclear Information System (INIS)

    Iglesias Gamarra, Antonio; Valle O, Rafael; Restrepo Suarez, Jose Felix

    2004-01-01

    In this paper we made an extensive and real compile about the history of spondyloarthropathies, since the early study of mammalian skeletons until the human being. Several authors demonstrated the presence of these diseases in skeletons from 3000 years BC. We discuss about the possible African or European origin of the spondyloarthropathies, the history about the firsts clinical, radiological and scintigraphic descriptions, the extra-articular findings, the family cases, and their treatment

  16. Business History as Cultural History

    DEFF Research Database (Denmark)

    Lunde Jørgensen, Ida

    The paper engages with the larger question of how cultural heritage becomes taken for granted and offers a complimentary view to the anthropological ʻCopenhagen School’ of business history, one that draws attention to the way corporate wealth directly and indirectly influences the culture available...

  17. Optimal treatment sequence in COPD: Can a consensus be found?

    Directory of Open Access Journals (Sweden)

    J. Ferreira

    2016-01-01

    Full Text Available There is currently no consensus on the treatment sequence in chronic obstructive pulmonary disease (COPD, although it is recognized that early diagnosis is of paramount importance to start treatment in the early stages of the disease. Although it is fairly consensual that initial treatment should be with an inhaled short-acting beta agonist, a short-acting muscarinic antagonist, a long-acting beta-agonist or a long-acting muscarinic antagonist. As the disease progresses, several therapeutic options are available, and which to choose at each disease stage remains controversial. When and in which patients to use dual bronchodilation? When to use inhaled corticosteroids? And triple therapy? Are the existing non-inhaled therapies, such as mucolytic agents, antibiotics, phosphodiesterase-4 inhibitors, methylxanthines and immunostimulating agents, useful? If so, which patients would benefit? Should co-morbitities be taken into account when choosing COPD therapy for a patient?This paper reviews current guidelines and available evidence and proposes a therapeutic scheme for COPD patients. We also propose a treatment algorithm in the hope that it will help physicians to decide the best approach for their patients. The authors conclude that, at present, a full consensus on optimal treatment sequence in COPD cannot be found, mainly due to disease heterogeneity and lack of biomarkers to guide treatment. For the time being, and although some therapeutic approaches are consensual, treatment of COPD should be patient-oriented. Keywords: COPD, Treatment sequence, SABA, SAMA, LABA, LAMA, ICS, Triple therapy, Non-inhaled therapies

  18. The early history of modern ecological economics

    DEFF Research Database (Denmark)

    Røpke, Inge

    2004-01-01

    is inspired by other studies of the emergence of new research areas done by sociologists and historians of science, and includes both cognitive and social aspects, macro trends and the role of individuals. The basis for the paper is a combination of literature studies and interviews with key researchers from...... were given modern formulations, but it took a long gestation period from the beginning of the 1970s to the end of the 1980s, before ecological economics took shape. During this gestation period the personal relationships between the actors were formed, and the meetings that were decisive for the formal...

  19. The early history of modern ecological economics

    DEFF Research Database (Denmark)

    Røpke, Inge

    2004-01-01

    This paper provides a historical perspective for the discussion on ecological economics as a special field of research. By studying the historical background of ecological economics, the present discussions and tensions inside the field might become easier to understand and to relate to. The study...... is inspired by other studies of the emergence of new research areas done by sociologists and historians of science, and includes both cognitive and social aspects, macro trends and the role of individuals. The basis for the paper is a combination of literature studies and interviews with key researchers from...... the field. The story opens with the emergence of the new environmental agenda in the 1960s, which was influenced by the scientific development in biology and ecology. Then it is outlined how the environmental challenge was met by economics in the 1960s. Around 1970 the basic ideas of ecological economics...

  20. Early history of high-altitude physiology.

    Science.gov (United States)

    West, John B

    2016-02-01

    High-altitude physiology can be said to have begun in 1644 when Torricelli described the first mercury barometer and wrote the immortal words "We live submerged at the bottom of an ocean of the element air." Interestingly, the notion of atmospheric pressure had eluded his teacher, the great Galileo. Blaise Pascal was responsible for describing the fall in pressure with increasing altitude, and Otto von Guericke gave a dramatic demonstration of the enormous force that could be developed by atmospheric pressure. Robert Boyle learned of Guericke's experiment and, with Robert Hooke, constructed the first air pump that allowed small animals to be exposed to a low pressure. Hooke also constructed a small low-pressure chamber and exposed himself to a simulated altitude of about 2400 meters. With the advent of ballooning, humans were rapidly exposed to very low pressures, sometimes with tragic results. For example, the French balloon, Zénith, rose to over 8000 m, and two of the three aeronauts succumbed to the hypoxia. Paul Bert was the first person to clearly state that the deleterious effects of high altitude were caused by the low partial pressure of oxygen (PO2), and later research was accelerated by high-altitude stations and expeditions to high altitude. © 2015 New York Academy of Sciences.

  1. Inertial confinement: concept and early history

    International Nuclear Information System (INIS)

    Linhart, J.G.

    1986-01-01

    The concept of inertial confinement is linked to the general theme of energy compression and staging. It is shown how it arose from the ideas and experiments on dynamic pinches towards the end of the fifties and how the important key concept of a linear was further developed during the sixties. THe various attempts at driving linears to speeds in excess of 1 cm/μs are reviewed in chronological order, mentioning the important impetus given to this field by the consideration of laser as a driver. It is concluded that the field of inertial confinement fusion (ICF) is becoming ever richer in possibilities, and the understanding of the physics of high-energy density has reached now a satisfactory level

  2. The early history of polyamine research.

    Science.gov (United States)

    Bachrach, Uriel

    2010-07-01

    In 1678 Antonie van Leeuwenhoek identified crystalline substances in human semen. The structure of these crystals, named "spermine", was not elucidated by Rosenheim until 250 years later. Subsequently a triamine (spermidine) and a diamine (putrescine; 1,4-diaminobutane) were isolated from prokaryotic and eukaryotic systems. Soon it became apparent that polyamines can promote the growth of fastidious bacteria. Subsequently a group in Helsinki studied the accumulation of polyamines in regenerating rat liver, while Caldarera and his group studied polyamine synthesis in the developing chick embryo. These investigations led to metabolic studies. Ornithine decarboxylase was identified as a key enzyme in polyamine biosynthesis, while polyamine and diamine oxidations were studied by Mondovì. alpha-Diflouromethylornithine (DFMO) was synthesized by Merrell-Dow and became a potent inhibitor of ornithine decarboxylase. The findings of Russell that polyamines are excreted in the urine of cancer patients drew the attention of oncologists, who attempted the use new technologies for the detection of cancer and improving therapy. With the advance of molecular biology the structure of polyamine-biosynthetic enzymes was elaborated. Plants served as another important tool to study the physiological functions of polyamines. Bagni and his group at Bologna were pioneers in that field and for more than forty-six years set the foundation of a most interesting discipline. 2010 Elsevier Masson SAS. All rights reserved.

  3. The early history of the HPD

    International Nuclear Information System (INIS)

    Powell, B.

    1994-01-01

    The initial stages of the development of a system for the rapid measurement of bubble chamber photographs are described. At first called the IEP-X and then IEP-Y, the device which came to be known as the HPD was adopted by several groups both in Europe and the USA. Based on a mechanically generated flying spot, it was the first machine to use this technique for bubble chamber film measurement. Operated in the ''road guidance'' mode, it provided considerable measurement capacity combined with excellent precision and very acceptable bubble density measurements. ((orig.))

  4. Early history of cosmic rays at Chicago

    Science.gov (United States)

    Yodh, Gaurang B.

    2013-02-01

    Cosmic ray studies at the University of Chicago were started by Arthur Compton during the late 1920s. The high points of cosmic ray studies at Chicago under Compton and Marcel Schein are the focus of this report, which summarizes the research done at Chicago up to the end of World War II.

  5. Embryonic vaccines against cancer: an early history.

    Science.gov (United States)

    Brewer, Bradley G; Mitchell, Robert A; Harandi, Amir; Eaton, John W

    2009-06-01

    Almost 100 years have passed since the seminal observations of Schöne showing that vaccination of animals with fetal tissue would prevent the growth of transplantable tumors. Many subsequent reports have affirmed the general idea that immunologic rejection of transplantable tumors, as well as prevention of carcinogenesis, may be affected by vaccination with embryonic/fetal material. Following a decade of intense research on this phenomenon during approximately 1964-1974, interest appears to have waned. This earlier experimental work may be particularly pertinent in view of the rising interest in so-called cancer stem cells. We believe that further work - perhaps involving the use of embryonic stem cells as immunogens - is warranted and that the results reviewed herein support the concept that vaccination against the appearance of cancers of all kinds is a real possibility.

  6. River history.

    Science.gov (United States)

    Vita-Finzi, Claudio

    2012-05-13

    During the last half century, advances in geomorphology-abetted by conceptual and technical developments in geophysics, geochemistry, remote sensing, geodesy, computing and ecology-have enhanced the potential value of fluvial history for reconstructing erosional and depositional sequences on the Earth and on Mars and for evaluating climatic and tectonic changes, the impact of fluvial processes on human settlement and health, and the problems faced in managing unstable fluvial systems. This journal is © 2012 The Royal Society

  7. Environmental History

    OpenAIRE

    Kearns, Gerard

    2004-01-01

    There was a time when almost all Western geography could be termed environmental history. In the late nineteenth century, physical geographers explained landscapes by describing how they had evolved. Likewise, human geographers saw society as shaped by the directing hands of the environment. By the 1960s this had very much changed. Process studies shortened the temporal framework in geographical explanation and cut the cord between nature and society. Now, physical and human...

  8. Roots of neuroanatomy, neurology, and neurosurgery as found in the Bible and Talmud.

    Science.gov (United States)

    Tubbs, R Shane; Loukas, Marios; Shoja, Mohammadali M; Cohen-Gadol, Aaron A; Wellons, John C; Oakes, W Jerry

    2008-07-01

    Historical observations and interpretations regarding the treatment of components of the nervous system can be found in the writings of the Bible and Talmud. A review of topics germane to modern neuroanatomy, neurology, and neurosurgery from these early, rich writings is presented herein. These historic writings provide a glimpse into the early understanding, description, and treatment of pathologies of the nervous system.

  9. TEACHERS' GUIDES. WORLD HISTORY FOR THE ACADEMICALLY TALENTED. ADVANCED PLACEMENT EUROPEAN HISTORY.

    Science.gov (United States)

    AUGSPURGER, EVERETT F.; AND OTHERS

    PREPARED BY TEACHERS AND SUPERVISORS WORKING WITH A 2-YEAR DEMONSTRATION PROJECT, THIS DOCUMENT CONTAINS GUIDES FOR A WORLD HISTORY COURSE (PREHISTORY TO EARLY 20TH CENTURY) FOR THE GIFTED AND AN ADVANCED PLACEMENT COURSE IN EUROPEAN HISTORY (ANCIENT CIVILIZATION TO EARLY 20TH CENTURY). STUDENTS ARE EXPECTED TO STUDY HISTORICAL ISSUES AND DEVELOP…

  10. Sommerferiens historie

    DEFF Research Database (Denmark)

    Lützen, Karin

    2011-01-01

    Summer holiday is a pleasure which did not become available to many people until the 20th Century. The article describes the early mountain rambles of the bourgeoisie and their holidays in seaside boarding houses. Outdoor pursuits and stays in boarding houses at bathing resorts also became...

  11. Parental death and bipolar disorder: a robust association was found in early maternal suicide

    DEFF Research Database (Denmark)

    Tsuchiya, Kenji; Agerbo, Esben; Mortensen, Preben Bo

    2005-01-01

    of a conditional logistic regression analysis. RESULTS: Among 947 subjects with bipolar disorder and 47,350 controls, those having experienced the parental suicide were significantly associated with an increased risk for BPD (incidence rate ratios: 1.83 [95% confidence interval: 1.07 to 3.12] for paternal suicide......, 3.44 [1.97 to 6.00] for maternal suicide), whereas the non-suicidal death of parents showed no such association. Those having experienced maternal suicide at some point before reaching 10 years of age were seven times as likely to develop bipolar disorder. LIMITATIONS: The cohort members were...

  12. My brief history

    CERN Document Server

    Hawking, Stephen

    2013-01-01

    My Brief History recounts Stephen Hawking’s improbable journey, from his postwar London boyhood to his years of international acclaim and celebrity. Lavishly illustrated with rarely seen photographs, this concise, witty, and candid account introduces readers to a Hawking rarely glimpsed in previous books: the inquisitive schoolboy whose classmates nicknamed him Einstein; the jokester who once placed a bet with a colleague over the existence of a particular black hole; and the young husband and father struggling to gain a foothold in the world of physics and cosmology. Writing with characteristic humility and humor, Hawking opens up about the challenges that confronted him following his diagnosis of ALS at age twenty-one. Tracing his development as a thinker, he explains how the prospect of an early death urged him onward through numerous intellectual breakthroughs, and talks about the genesis of his masterpiece A Brief History of Time—one of the iconic books of the twentieth century.

  13. The first 800 million years of earth's history

    Science.gov (United States)

    Smith, J. V.

    1981-01-01

    It is pointed out that there is no direct geological information on the first 750 Ma of earth history. Consequently the reported study is based on controversial inferences drawn from the moon, other planets and meteorites, coupled with backward extrapolation from surviving terrestrial rocks, especially those of Archaean age. Aspects of accretion are considered, taking into account cosmochemical and cosmophysical evidence, a new earth model, and convection systems. Attention is given to phase-equilibrium constraints, estimates of heat production, the bombardment history of the moon and implications for the earth, and the nature of the early crust. From a combination of physical, chemical, and petrological arguments, it is concluded that the earth's surface underwent intense volcanism in the pre-Archaean era, and that the rock types were chemically similar to those found in the early Archaean era.

  14. History of Mars

    International Nuclear Information System (INIS)

    Lewis, J.S.

    1988-01-01

    The origin and early history of Mars and the relationship between Mars and the other planets are reviewed. The solar system formation and planetary differentiation are examined using data from planetary missions. Different views of Mars are presented, showing how ideas about the planet have changed as the amount of available observational data has increased. Viking aerography and surface characterization are discussed, including the nature of specific atmospheric components and the implications of surface phenomena. Models for the planetary formation and accretion processes are considered. The value of future missions to Mars is stressed

  15. Uncovering History for Future History Teachers

    Science.gov (United States)

    Fischer, Fritz

    2010-01-01

    The art of history teaching is at a crossroads. Recent scholarship focuses on the need to change the teaching of history so students can better learn history, and insists that history teachers must move beyond traditional structures and methods of teaching in order to improve their students' abilities to think with history. This article presents…

  16. Migrant Men in Misery : Result from a Qualitative Life History Analysis on Individuals and Families Concerning Internal Migration, Health and Life Circumstances in Early 19th Century, Linköping, Sweden

    Directory of Open Access Journals (Sweden)

    Nygren, Victoria

    2007-07-01

    Full Text Available The purpose of this article is to explore and understand under what health and life circumstances internal migrants lived, in a small early 19th century Swedish town during a time of considerable social change, and also how these migrants coped with their everyday lives. By following a small number of men throughout their lives in a family context, using mainly church registers, a group of ‘migrant men in misery’ has been qualitatively discerned. These men´s problems were found to peak in a phase of their lives when they lived in town with wives and children to support. The wives shared the tough life in town with their husbands but the overall impression still support a conclusion which put the spouses´ different gender roles´ in a stressful situation in focus, where a lack of social integration in town could be an additional factor.

  17. The Pattern of Significant Lesions Found in Computerized ...

    African Journals Online (AJOL)

    2017-06-09

    Jun 9, 2017 ... 2017 Nigerian Journal of Clinical Practice | Published by Wolters Kluwer ‑ Medknow. Introduction: ... other neurological findings or history suggestive of their causes. .... among pediatric patients in Enugu, structural lesion was.

  18. History of the National Weather Service - Public Affairs - NOAA's National

    Science.gov (United States)

    enter or select the go button to submit request City, St Go About NWS -Mission -Strategic Plan -History and local government web resources and services. Home >> History History of the National Weather Service The National Weather Service has its beginnings in the early history of the United States. Weather

  19. Geologic data on atmospheric history

    NARCIS (Netherlands)

    Rutten, M.G.

    1966-01-01

    Attention is focussed on the possible existence of an anoxygenic, primeval atmosphere and on the history of atmospheric O2 and CO2. For this purpose, geologic data can be divided into those on fossil remains, on biogenic deposits formed by early life, on “chemicofossils”, and on deposits formed

  20. Cygnus History

    International Nuclear Information System (INIS)

    Henderson, David J.; Gignac, Raymond E.; Good, Douglas E.; Hansen, Mark D.; Mitton, Charles V.; Nelson, Daniel S.; Ormond, Eugene C.; Cordova, Steve R.; Molina, Isidro; Smith, John R.; Rose, Evan A.

    2009-01-01

    The Cygnus Dual Beam Radiographic Facility consists of two identical radiographic sources: Cygnus 1 and Cygnus 2. This Radiographic Facility is located in an underground tunnel test area at the Nevada Test Site. The sources were developed to produce high-resolution images for dynamic plutonium experiments. This work will recount and discuss salient maintenance and operational issues encountered during the history of Cygnus. A brief description of Cygnus systems and rational for design selections will set the stage for this historical narrative. It is intended to highlight the team-derived solutions for technical problems encountered during extended periods of maintenance and operation. While many of the issues are typical to pulsed power systems, some of the solutions are unique. It is hoped that other source teams will benefit from this presentation, as well as other necessary disciplines (e.g., source users, system architects, facility designers and managers, funding managers, and team leaders)

  1. Environmental history

    DEFF Research Database (Denmark)

    Pawson, Eric; Christensen, Andreas Aagaard

    2017-01-01

    Environmental history is an interdisciplinary pursuit that has developed as a form of conscience to counter an increasingly powerful, forward-looking liberal theory of the environment. It deals with the relations between environmental ideas and materialities, from the work of the geographers George...... Perkins Marsh, Carl Sauer, and Clarence Glacken, to more recent global-scale assessments of the impact of the “great acceleration” since 1950. Today’s “runaway world” paradoxically embraces risk management in an attempt to determine its own future whilst generating a whole new category of “manufactured...... risks”. These are exposed by environmental history’s focus on long-run analysis and its narrative form that identifies the stories that we tell ourselves about nature. How a better understanding of past environmental transformations helps to analyse society and agency, and what this can mean...

  2. Found: The Original 1945 Records of Australian Radio Astronomy

    Science.gov (United States)

    Goss, Miller; Ekers, Ron; Sim, Helen

    2015-08-01

    In July 2014, we found the original records of the first published Australian radio astronomy observations. These were obtained by Joseph L. Pawsey and Ruby Payne-Scott in early October 1945. The observations gave strong evidence of a million degree corona as well as frequent radio bursts.These observations followed earlier detections of the radio sun by Stanley Hey, George Southworth, Grote Reber and Elizabeth Alexander. The latter observations (the "Norfolk Island Effect" of March 1945) were the immediate motivation for the campaign carried out by Pawsey and Payne-Scott.These observations formed the basis for a number of pioneering publications: the 9 February 1946 Nature paper of Pawsey, Payne-Scott and McCready which was submitted on the last date on which data was obtained on 23 October 1945, the major publication of the initial Australian radio solar publication in the Proceedings of the Royal Society of London in August 1947 and Pawsey's presentation of the radio properties of the million degree corona in the Nature of 2 November 1946. Contemporaneously with these publications, D. F.Martyn was involved in an independent theoretical study of the properties of the solar corona.(Ginzburg and Shklovsky were also involved in this era in a study of the properties of the corona.) The back-to-back Martyn and Pawsey Nature papers were the first that described the radio properties of the hot corona, due to free-free emission. The division of the observed emission into "bursting" and "quiet" modes was challenging for the novice radio astronomers.These historical records had been recognized by Paul Wild in 1968, who instructed the CSIRO Division of Radiophysics secretary to E.("Taffy") G. Bowen, Ms. Sally Atkinson, to submit these to the Australian Academy of Science. Wild characterized these documents as "of considerable historical interest". Apparently the transmission of the documents was not done; a thorough search of the Australian Academy Library in August 2014

  3. Public History

    Directory of Open Access Journals (Sweden)

    Marta Gouveia de Oliveira Rovai

    2017-04-01

    Full Text Available Este artigo tem como proposta apresentar o conceito e as práticas de História Pública como um novo posicionamento da ciência histórica em diálogo com profissionais da comunicação, no sentido de produzir e divulgar as experiências humanas. Para isso, discute-se a origem do conceito de História Pública e as diferentes formas de educação histórica que a utilização das novas tecnologias podem proporcionar (dentre elas a internet. Nesse sentido, convida-se o leitor para a reflexão sobre as possibilidades de publicização e de democratização do conhecimento histórico e da cultura, ampliando-se a oportunidade de produção, de divulgação e de acesso do público a diferentes formas experiências no tempo. O artigo também intenciona chamar atenção dos profissionais que lidam com a História e com a Comunicação para os perigos de produções exclusivamente submetidas ao mercado que transformam a popularização da História no reforço de estigmas culturais.   PALAVRAS-CHAVE: História Pública; Educação histórica e Comunicação; democratização e estigmatização.     ABSTRACT This article aims to present the concept and practices of Public History as a new positioning of historical science in dialogue with communication professionals, in the sense of producing and disseminating human experiences. For this, the origin of the concept of Public History and the different forms of historical education that the use of the new technologies can provide (among them the Internet is discussed. In this sense, the reader is invited to reflect on the possibilities of publicizing and democratizing historical knowledge and culture, expanding the opportunity for production, dissemination and public access to different forms of experience in time. The article also intends to draw attention from professionals dealing with History and Communication to the dangers of exclusively commercialized productions that transform the popularization

  4. Frequency of ill-founded off-label prescribing in Dutch general practice.

    NARCIS (Netherlands)

    Gijsen, R.; Jochemsen, H.; Dijk, L. van; Caspers, P.

    2009-01-01

    Purpose: The aim of this study is to quantify the extent of ill-founded off-label drug prescriptions in Dutch general practice. The study is based upon information on both the prescription itself and the patient’s medical history. Methods: In total, 48 combinations of drugs and off-label indications

  5. Francis Bacon's natural history and civil history: a comparative survey.

    Science.gov (United States)

    Manzo, Silvia

    2012-01-01

    The aim of this paper is to offer a comparative survey of Bacon's theory and practice of natural history and of civil history, particularly centered on their relationship to natural philosophy and human philosophy. I will try to show that the obvious differences concerning their subject matter encompass a number of less obvious methodological and philosophical assumptions which reveal a significant practical and conceptual convergence of the two fields. Causes or axioms are prescribed as the theoretical end-products of natural history, whereas precepts are envisaged as the speculative outcomes derived from perfect civil history. In spite of this difference, causes and precepts are thought to enable effective action in order to change the state of nature and of man, respectively. For that reason a number of common patterns are to be found in Bacon's theory and practice of natural and civil history.

  6. Palaeogene to Early Miocene sedimentary history of the Sierra Espuña (Malaguide complex, internal zone of the Betic cordilleras, SE Spain. Evidence for extra-Malaguide (Sardinian? provenance of oligocene conglomerates: Palaeogeographic implications

    Directory of Open Access Journals (Sweden)

    Geel, T.

    1996-12-01

    Full Text Available The Sierra Espuña is situated at the northern edge of the Internal Zone in the eastern Betic Cordilleras and is part of the unmetamorphosed Malaguide Complex. Palaeontological and sedimentological analysis of the Eocene to Aquitanian sediments on the northwest side of the Espuña yielded unexpected new information of importance for the reconstruction of the history of the Espuña itself and the Malaguides in general. The socalled Upper Eocene (Auversian rocks are of Early Oligocene (P20 age and contain supermature detritus derived from outside the Malaguide realm. The hundreds of meters thick limestone conglomerate formation of the Espuña is of Middle Oligocene (P21 age and represents a backstepping fan delta complex at the margin of a carbonate platform situated to the northeast of the Espuña. Analysis of the clasts suggests that this platform was a part of the north Sardinian block given the majority of fragments of Upper Jurassic sheltered inner platform (Clypeina-Trocholina limestones and dolomites. Contrary to former views (Paquet, 1966; Lonergan, 1993, the conglomerates cannot be considered to be the erosional products of Malaguide imbricated units. Therefore, one of the main arguments for early (Late Eocene to Oligocene thrusting and nappe emplacement in the Espuña area is not valido Other arguments for early kinematics are discussed, among others the allegedly continuous sedimentation from the Late Eocene until the Langhian northwest of the Espuña. Our data indicate the existence of a stratigraphic gap, comprising the middle Aquitanian to middle Burdigalian. A new model for the development of the Espuña within the Malaguide realm during the Palaeogene to Early Miocene is presented. Main thrusting and nappe emplacement is thought to have been taken place during the late Aquitanian. Finally, the recently proposed 2000 clockwise rotation of the Espuña as a coherent block during the Early to Middle Miocene (AlIerton el al., 1993 is

  7. Oral History as Educational Technology Research

    Science.gov (United States)

    Butler, Rebecca P.

    2008-01-01

    Oral history is a significant type of historical research. Its use in retaining records of the early days of educational technology provides another way to look at the history of this field. The remembrances of its founders inform everyone today of, not only of what went on before, but also of how current and future technologies evolve. There are…

  8. History of Rotating Machine Development and Foresight

    Science.gov (United States)

    Tari, Makoto; Nagano, Susumu; Amemori, Shiro; Aso, Toshiyuki

    The history of electrical rotating machines such as generators and motors in Japan is around one hundred years. At early stage, all machines were imported from foreign countries, but now domestic industries introduce new concept of machines and are leading these kinds of technology. Reviewing of history and development and foresight seems meaningful for further development.

  9. Insights into the Early to Late Oligocene Izu-Bonin Mariana Arc Magmatic History from Volcanic Minerals and Glass within Volcaniclastic Sediments of IODP Site U1438 and DSDP Site 296

    Science.gov (United States)

    Samajpati, E.; Hickey-Vargas, R.

    2017-12-01

    The Kyushu-Palau Ridge (KPR) is a remnant of the early Izu-Bonin-Mariana (IBM) island arc, separated by arc rifting and seafloor spreading. We examine and compare volcanic materials from two sites where the transition from IBM arc building to rifting is well sampled: DSDP Site 296 on the northern KPR crest, and recent IODP Site U1438 in the adjacent Amami-Sankaku basin to the west. The purpose of the study is to understand the origin and depositional regime of volcaniclastic sediments during the arc rifting stage. Site 1438 sedimentary Unit II and the upper part of Unit III (300 and 453 mbsf) correlate in time with sedimentary Units 1G and 2 of DSDP Site 296 (160 and 300 mbsf). The upper part of Site U1438 Unit III and Site 296 Unit 2 consist of early to late Oligocene coarse volcaniclastic sedimentary rocks. These are overlain by late Oligocene nannofossil chalks with volcanic sand and ash-rich layers at Site 296 Unit 1G, and tuffaceous silt, sand, siltstone and sandstone at Site 1438 Unit II. The chemical composition of volcanic glass shards, pyroxenes with melt inclusions and amphiboles separated from volcaniclastic sediments were analyzed by EPMA and LA-ICPMS. Glasses are found at Site 296 only, range from medium-K basalt to rhyolite and have trace element patterns typical of arc volcanics. Clinopyroxene and orthopyroxene are found as detrital grains in sediments from both sites. Mg-numbers range from 58 to 94. Interestingly, the alumina content of pyroxene grain populations from both sites increase and then decrease with decreasing Mg-number. This probably reflects control of Al contents in magma and pyroxene by suppressed plagioclase saturation, which apparently was a consistent feature of KPR volcanoes. Melt-inclusions within the pyroxenes are typically small (30-50 microns) and have similar chemical compositions within one grain. The melt inclusions range from basalt to rhyolite with moderate alkali content. Amphibole is more prevalent in late Oligocene

  10. Alma, mente e cérebro na pré-história e nas primeiras civilizações humanas Soul, mind and brain in pre-history and early human civilizations

    Directory of Open Access Journals (Sweden)

    Fabiano dos Santos Castro

    2010-04-01

    Full Text Available Atualmente, o debate sobre a natureza da mente humana vem tomando novos rumos graças ao desenvolvimento de diversos estudos, no campo das neurociências, que investigam a localização das funções cerebrais. Esses trabalhos vêm contribuindo para uma melhor compreensão dos substratos neurais das funções mentais, bem como da etiologia de diversos transtornos mentais. Entretanto, o conhecimento acumulado pela neurociência não ocorreu de forma súbita. Na verdade, o estudo das relações entre o cérebro e a mente não é recente. Da pré-história aos dias atuais, surgiram vários tipos de questionamentos a respeito da possível materialidade e localização das funções mentais humana. O presente trabalho apresenta, de forma histórica, como populações pré-históricas, assim como as primeiras civilizações, localizadas no Egito, na Mesopotâmia, na Índia e na China, desenvolveram e utilizaram conceitos relacionados com a alma, a mente e o cérebro humano.Currently, the debate about the nature of the human mind is taking new directions through the development of several studies in the field of neuroscience which investigates the location of brain functions. These studies have contributed to a better understanding of the neural substrates of mental functions and the etiology of various mental disorders. However, the knowledge developed by neuroscience did not occur abruptly. Indeed, the study of mind-brain relationship is not new. From pre-history to the present days, various different types of inquiries have been made about the possible materiality and location of human mental functions. This paper presents, in a historic manner, how prehistoric populations as well as early civilizations located in Egypt, Mesopotamia, India, and China developed and employed concepts related to the soul, the mind and the human brain.

  11. QUATERNARY HISTORY OF CEDRUS IN SOUTHERN EUROPE

    Directory of Open Access Journals (Sweden)

    D. Magri

    2012-05-01

    Full Text Available A database of 68 pollen records of Pleistocene age was compiled from the western Mediterranean regions, with the aim of reconstructing the history of Cedrus in south Europe during the last 2 Ma. Marine pollen records from the Alboran Sea suggest that Cedrus was present in Morocco throughout the Quaternary, while it was absent from the Iberian peninsula, except a possible local presence in a coastal site of southern Spain. In France, Cedrus pollen was recorded in Pliocene deposits, but its Quaternary finds are always very sparse and suggest a long distance origin of cedar pollen. Cedrus was widespread in all the Italian sites during the Early Pleistocene, but it is sporadically found in the Middle Pleistocene deposits. Although times and modes of the disappearance of Cedrus from Italy are not known, it appears that the marked climate changes occurred between 0.9 and 0.7 Ma determined its local extinction. A similar trend is found in Greece, where Cedrus may have persisted a little longer than in the Italian Peninsula. On the whole, the history of Cedrus in southern Europe indicates that it is a taxon vulnerable to global climate changes and warns of a future risk of extinction also in the rest of the Mediterranean Basin.

  12. Found Performance”: Towards a Musical Methodology for Exploring the Aesthetics of Care

    Directory of Open Access Journals (Sweden)

    Stuart Wood

    2017-09-01

    Full Text Available Concepts of performance in fine art reflect key processes in music therapy. Music therapy enables practitioners to reframe patients as performers, producing new meanings around the clinical knowledge attached to medical histories and constructs. In this paper, music therapy practices are considered in the wider context of art history, with reference to allied theories from social research. Tracing a century in art that has revised the performativity of found objects (starting with Duchamp’s “Fountain”, and of found sound (crystallised by Cage’s 4′ 33 this paper proposes that music therapy might be a pioneer methodology of “found performance”. Examples from music therapy and contemporary socially engaged art practices are brought as potential links between artistic methodologies and medical humanities research, with specific reference to notions of Aesthetics of Care.

  13. "Found Performance": Towards a Musical Methodology for Exploring the Aesthetics of Care.

    Science.gov (United States)

    Wood, Stuart

    2017-09-18

    Concepts of performance in fine art reflect key processes in music therapy. Music therapy enables practitioners to reframe patients as performers, producing new meanings around the clinical knowledge attached to medical histories and constructs. In this paper, music therapy practices are considered in the wider context of art history, with reference to allied theories from social research. Tracing a century in art that has revised the performativity of found objects (starting with Duchamp's "Fountain"), and of found sound (crystallised by Cage's 4' 33) this paper proposes that music therapy might be a pioneer methodology of "found performance". Examples from music therapy and contemporary socially engaged art practices are brought as potential links between artistic methodologies and medical humanities research, with specific reference to notions of Aesthetics of Care.

  14. Max Hirsch (1875-1941): His forgotten fate and his contributions to the founding of modern rheumatology.

    Science.gov (United States)

    Keitel, Wolfgang; Olsson, Leif; Matteson, Eric L

    2016-09-01

    To elucidate the connections between balneology and rheumatology in the founding period of the discipline of rheumatology, and describe the contributions of Max Hirsch, MD in the formation of professional rheumatology societies. Historical documents from the medical history collection of Vogelsang-Gommern, Germany, and original personal documents of the Hirsch family and information from the medical and historical period literature were used in developing this report. The first efforts at organizing rheumatology as a recognized clinical and academic discipline took place in the 1920s. Many of the first proponents were balneologists who cared for patients with chronic arthritic conditions without the benefit of effective medications. Max Hirsch, MD was a major figure in the development of modern rheumatology as it emerged from the provenance of balneology and orthopedics as a recognized organized medical discipline, contributing to the founding of the German Society for Rheumatology and the International League Against Rheumatism. Max Hirsch made significant contributions to scientific and organized rheumatology in the early days of the discipline. His contributions to the field and his fate as a Jewish physician have only recently come to light.

  15. Early diagnosis and screening for colorectal cancer

    International Nuclear Information System (INIS)

    Laufer, I.

    1986-01-01

    The barium enema has been a neglected tool in the diagnosis of early colon cancer. With appropriate attention to technical detail, the double contrast enema is capable of detecting the smallest malignant and pre-malignant lesions. Many of these early colon cancers are found in asymptomatic patients and these lesions are curable. The goal of a screening program should be to identify by history or by fecal occult blood testing patients at high risk for the development of colon cancer. These patients should be examined by high-quality double contrast enema in the search for these potentially lethal but curable lesions. In addition, we believe that any patient undergoing radiologic examination of the colon for whatever reason, should receive an examination of adequate quality to rule out an early colon cancer. (Author)

  16. Organizing the History of Computing

    Science.gov (United States)

    Misa, Thomas J.

    This paper tries to distill some of the ‘lessons learned’ from the Charles Babbage Institute’s quarter-century experience (1980-present) in organizing the history of computing. It draws on the author’s (recent) experience as CBI director; conversations with Arthur Norberg, CBI’s long-time founding director; and papers delivered at a special symposium appraising CBI’s role in computing history, which appeared in the IEEE Annals of the History of Computing 29 no. 4 (October-December 2007).

  17. Nest Relocation and Colony Founding in the Australian Desert Ant, Melophorus bagoti Lubbock (Hymenoptera: Formicidae

    Directory of Open Access Journals (Sweden)

    Patrick Schultheiss

    2010-01-01

    Full Text Available Even after years of research on navigation in the Red Honey Ant, Melophorus bagoti, much of its life history remains elusive. Here, we present observations on nest relocation and the reproductive and founding stages of colonies. Nest relocation is possibly aided by trail laying behaviour, which is highly unusual for solitary foraging desert ants. Reproduction occurs in synchronised mating flights, which are probably triggered by rain. Queens may engage in multiple matings, and there is circumstantial evidence that males are chemically attracted to queens. After the mating flight, the queens found new colonies independently and singly. Excavation of these founding colonies reveals first insights into their structure.

  18. 50 CFR 25.22 - Lost and found articles.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Lost and found articles. 25.22 Section 25.22 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... Lost and found articles. Lost articles or money found on a national wildlife refuge are to be...

  19. 36 CFR 327.16 - Lost and found articles.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Lost and found articles. 327... CHIEF OF ENGINEERS § 327.16 Lost and found articles. All articles found shall be deposited by the finder at the Manager's office or with a ranger. All such articles shall be disposed of in accordance with...

  20. Larch dwarf mistletoe not found on alpine larch

    Science.gov (United States)

    Robert L. Mathiasen; Brian W. Geils; Clinton E. Carlson; Frank G. Hawksworth

    1995-01-01

    Reports of larch dwarf mistletoe parasitizing alpine larch are based on two collections of this host/parasite combination made by J.R. Weir in Montana during the early 1900s. Examination of host material from these collections indicates that the host is western larch, not alpine larch as previously reported. Attempts to locate larch dwarf mistletoe on alpine larch were...

  1. Celebrate Women's History.

    Science.gov (United States)

    Leonard, Carolyn M.; Baradar, Mariam

    This teachers' guide to activities celebrating Women's History Month focuses on women whose important contributions have been omitted from history textbooks. Women's History Month grew from a 1977 celebration of Women's History Week and is intended to bring women's history into the school curriculum. International Women's Day, celebrated on March…

  2. History of Solid Rockets

    Science.gov (United States)

    Green, Rebecca

    2017-01-01

    Solid rockets are of interest to the space program because they are commonly used as boosters that provide the additional thrust needed for the space launch vehicle to escape the gravitational pull of the Earth. Larger, more advanced solid rockets allow for space launch vehicles with larger payload capacities, enabling mankind to reach new depths of space. This presentation will discuss, in detail, the history of solid rockets. The history begins with the invention and origin of the solid rocket, and then goes into the early uses and design of the solid rocket. The evolution of solid rockets is depicted by a description of how solid rockets changed and improved and how they were used throughout the 16th, 17th, 18th, and 19th centuries. Modern uses of the solid rocket include the Solid Rocket Boosters (SRBs) on the Space Shuttle and the solid rockets used on current space launch vehicles. The functions and design of the SRB and the advancements in solid rocket technology since the use of the SRB are discussed as well. Common failure modes and design difficulties are discussed as well.

  3. History of autostereoscopic cinema

    Science.gov (United States)

    Funk, Walter

    2012-03-01

    This paper covers the history of autostereoscopic cinema, from the beginnings of autostereoscopy in the 1800s, the development of motion capability and it's subsequent evolution to present techniques. Public viewings of autostereoscopic movies have occurred on a semi-ongoing basis since the early 1940s. In Moscow and other cities, theaters were constructed called stereokinos, for showing autostereoscopic films, with specially positioned seating for proper viewing. The Cyclostéréoscope was an autostereoscopic cinema system invented by François Savoye in France. It was based around a drum made of metal bars that revolve around a screen. For several years in the 1940s and 1950s, it was open to the public in Paris. Any film made in a dual film format could be shown. Besides dedicated theaters in Russia and France, exhibits of content have occurred outside devoted theaters. The paper focuses on the history of autostereoscopic technology developed for entertainment, public viewing of content, the individuals involved and the content itself.

  4. Decoding Galactic Merger Histories

    Directory of Open Access Journals (Sweden)

    Eric F. Bell

    2017-12-01

    Full Text Available Galaxy mergers are expected to influence galaxy properties, yet measurements of individual merger histories are lacking. Models predict that merger histories can be measured using stellar halos and that these halos can be quantified using observations of resolved stars along their minor axis. Such observations reveal that Milky Way-mass galaxies have a wide range of stellar halo properties and show a correlation between their stellar halo masses and metallicities. This correlation agrees with merger-driven models where stellar halos are formed by satellite galaxy disruption. In these models, the largest accreted satellite dominates the stellar halo properties. Consequently, the observed diversity in the stellar halos of Milky Way-mass galaxies implies a large range in the masses of their largest merger partners. In particular, the Milky Way’s low mass halo implies an unusually quiet merger history. We used these measurements to seek predicted correlations between the bulge and central black hole (BH mass and the mass of the largest merger partner. We found no significant correlations: while some galaxies with large bulges and BHs have large stellar halos and thus experienced a major or minor merger, half have small stellar halos and never experienced a significant merger event. These results indicate that bulge and BH growth is not solely driven by merger-related processes.

  5. The history of neuromyelitis optica

    Science.gov (United States)

    2013-01-01

    The discovery of a novel serum autoantibody (termed NMO-IgG or AQP4-Ab) in a subset of patients in 2004 has revived interest in neuromyelitis optica (NMO). While the history of classical multiple sclerosis has been extensively studied, only little is known about the history of NMO. In the present article, we provide a comprehensive review of the early history of this rare but intriguing syndrome. We trace the origins of the concept of NMO in the 19th century medical literature and follow its evolution throughout the 20th and into the 21st century. Finally, we discuss recent proposals to revise the concept of NMO and explain why there is indeed a need for a more systematic and descriptive nomenclature. PMID:23320783

  6. Fish Research Project, Oregon, Investigations into the Early Life History of Naturally Produced Spring Chinook Salmon in the Grande Ronde River Basin, Annual Progress Report, Project Period: September 1, 1996 - August 31, 1997; ANNUAL

    International Nuclear Information System (INIS)

    Brian C. Jonasson; J. Vincent Tranquilli; MaryLouise Keefe; Richard W. Carmichael

    1998-01-01

    We have documented two general life history strategies utilized by juvenile spring chinook salmon in the Grande Ronde River basin: (1) juveniles migrate downstream out of summer rearing areas in the fall, overwinter in river valley habitats, and begin their seaward migration in the spring, and (2) juveniles remain in summer rearing areas through the winter and begin seaward migration in the spring. In migration year 96-97, the patterns evident from migrant trap data were similar for the three Grande Ronde River populations studied, with 42% of the Lostine River migrants and 76% of the Catherine Creek migrants leaving upper rearing areas in the fall. Contrary to past years, the majority (98%) of upper Grande Ronde River migrants moved out in the fall. Total trap catch for the upper Grande Ronde River was exceedingly low (29 salmon), indicating that patterns seen this year may be equivocal. As in previous years, approximately 99% of chinook salmon juveniles moved past our trap at the lower end of the Grande Ronde River valley in the spring, reiterating that juvenile chinook salmon overwinter within the Grande Ronde valley section of the river. PIT-tagged fish were recaptured at Grande Ronde River traps and mainstem dams. Recapture data showed that fish that overwintered in valley habitats left as smolts and arrived at Lower Granite Dam earlier than fish that overwintered in upstream rearing areas. Fish from Catherine Creek that overwintered in valley habitats were recaptured at the dams at a higher rate than fish that overwintered upstream. In this first year of data for the Lostine River, fish tagged during the fall migration were detected at a similar rate to fish that overwintered upstream. Abundance estimates for migration year 96-97 were 70 for the upper Grande Ronde River, 4,316 for the Catherine Creek, and 4,323 for the Lostine River populations. Although present in most habitats, juvenile spring chinook salmon were found in the greatest abundance in pool

  7. Was bioethics founded on historical and conceptual mistakes about medical paternalism?

    Science.gov (United States)

    McCullough, Laurence B

    2011-02-01

    Bioethics has a founding story in which medical paternalism, the interference with the autonomy of patients for their own clinical benefit, was an accepted ethical norm in the history of Western medical ethics and was widespread in clinical practice until bioethics changed the ethical norms and practice of medicine. In this paper I show that the founding story of bioethics misreads major texts in the history of Western medical ethics. I also show that a major source for empirical claims about the widespread practice of medical paternalism has been misread. I then show that that bioethics based on its founding story deprofessionalizes medical ethics. The result leaves the sick exposed to the predatory power of medical practitioners and healthcare organizations with only their autonomy-based rights to non-interference, expressed in contracts, to protect them. The sick are stripped of the protection afforded by a professional, fiduciary relationship of physicians to their patients. Bioethics based on its founding story reverts to the older model of a contractual relationship between the sick and medical practitioners not worthy of intellectual or moral trust (because such trust cannot be generated by what I call 'deprofessionalizing bioethics'). On closer examination, bioethics based on its founding story, ironically, eliminates paternalism as a moral category in bioethics, thus causing bioethics to collapse on itself because it denies one of the necessary conditions for medical paternalism. Bioethics based on its founding story should be abandoned. © 2010 Blackwell Publishing Ltd.

  8. Transnational and entangled histories of National Socialism? The Turkish dimension of German interwar history

    OpenAIRE

    Ihrig, Stefan

    2016-01-01

    The history of National Socialism is mostly narrated and researched within its national, German context. While it appears obvious that Germany was interconnected with the broader world at the time, this has had little impact on our understanding of the history of National Socialism. This article investigates the Turkish dimension of especially early National Socialism and shows how debates on Turkey and recent events there influenced and shaped debates in the German media in the early Weimar ...

  9. Decades lost and found: Mexico and Chile since 1980

    OpenAIRE

    Raphael Bergoeing; Patrick J. Kehoe; Timothy J. Kehoe; Raimundo Soto

    2002-01-01

    Both Chile and Mexico experienced severe economic crises in the early 1980s, yet Chile recovered much faster than Mexico. This study analyzes four possible explanations for this difference and rules out three, explanations based on money supply expansion, real wage and real exchange rate declines, and foreign debt overhangs. The fourth explanation is based on government policy reforms in the two countries. Using growth accounting and a calibrated growth model, the study determines that the on...

  10. Characteristics of early psychosis

    NARCIS (Netherlands)

    Schothorst, P.F.; Emck, C.; van Engeland, H.

    2006-01-01

    There is little research on characteristics related to course and prognosis of early-onset psychosis. The present article aims to advance our knowledge of this disorder for the purpose of proper diagnosis and treatment. It focuses on premorbid and prodromal characteristics, treatment history,

  11. Medical Connections and Exchanges in the Early Modern World

    Directory of Open Access Journals (Sweden)

    Michael Naylor Pearson

    2011-12-01

    Full Text Available For most of human history there have been extensive exchanges of medical information all over Eurasia. Some diseases were considered to be geographically determined, and hence had to be cured using local knowledge. Other ailments were found in many places, but cures could differ according to location. Most healers, whether book based or experiential, took a non-judgemental approach to different healing methods, as seen especially in India in the early colonial period.

  12. What Does Dance History Have to Do with Dancing? Making College Dance History Usable for Dancers

    Science.gov (United States)

    Kattner, Elizabeth

    2016-01-01

    This paper explores methods for bringing dance history directly into the studio. It shows how the movement components that have proven successful in introductory courses can be extended to in-depth studies of dance history with dancers who have formal training. Through the example of a research project on the early work of George Balanchine, it…

  13. Simplified Dynamic Structural Time History Response Analysis of Flexible Approach Walls Founded on Clustered Pile Groups Using Impact_Deck

    Science.gov (United States)

    2016-07-01

    wa ll (k ip s) 0 0.5 1 1.5 2 2.5 3 3.5 4 0 100 200 300 400 500 600 ERDC/ITL TR-16-1 7 An alternative formulation incorporated within the PC...Vetterling, and B. P. Flannery. 1996. Numerical recipes in Fortran 77, the art of scientific computing, Second edition, New York, NY. Reddy, J. N...8544. 1 TO 3 70 UNSP S 0.6 0.6 500 . 500 . N 1 TO 3 80 PMAXMOM 324. 324. 1 TO 3 CPGA LOAD-DISPLACEMENT OUTPUT FOR RUN #1 Pinned-head piles PILE CAP

  14. Varjatud ajalugu ehk kuidas eksiilkunst kodu leidis = Hidden history, or how an exiled art found a home / Steven Mansbach

    Index Scriptorium Estoniae

    Mansbach, Steven, 1950-

    2009-01-01

    Euroopa 20. saj. kunsti ajaloo õpetamisest Ameerikas. Pärast Teist maailmasõda Ameerikasse emigreerunud kunstiteadlaste tegevusest. Ignoreerivast suhtumisest Ida-Euroopa maade kunsti. Geograafiliste, ajaliste ja kultuuriliste eripärade ületamise vajadusest

  15. Founding of ''European Mutual Association for Nuclear Insurance'' (EMANI)

    International Nuclear Information System (INIS)

    Gulck, A. van

    1979-01-01

    A brief account is given of the study leading to and the founding of the European pool for Nuclear Insurance concerning the liability for damage to property. The subject is dealt with under the following headings: the structure of insurance guarantee in a nuclear plant, insurances against nuclear risks and fires, founding project of a European Mutual Insurance, following the American experience and founding of ENAMI by the nuclear power plants operators and energy producers of Belgium, Denmark, Finland, France, United Kingdom, Ireland, the Netherlands, Sweden and Switzerland. (AF)

  16. "Brought under the law of the land" : the history, demography and geography of crossculturalism in early modern Izmir, and the Köprülü Project of 1678

    NARCIS (Netherlands)

    Olnon, Merlijn

    2014-01-01

    The port-city of Izmir (old Smyrna) plays a crucial role in modern world history. From the 1570s, that city became subjected to European mercantile interests and quickly developed into the main conductor of an irreversible European takeover of the Ottoman economy – the structural basis of a

  17. History of early abuse as a predictor of treatment response in patients with fibromyalgia : A post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release

    NARCIS (Netherlands)

    Pae, Chi-Un; Masand, Prakash S.; Marks, David M.; Krulewicz, Stan; Han, Changsu; Peindl, Kathleen; Mannelli, Paolo; Patkar, Ashwin A.

    2009-01-01

    Objectives. We conducted a post-hoc analysis to determine whether a history of physical or sexual abuse was associated with response to treatment in a double-blind, randomized, placebo-controlled trial of paroxetine controlled release (CR) in fibromyalgia. Methods. A randomized, double-blind,

  18. Early Islamic Syria

    DEFF Research Database (Denmark)

    Walmsley, Alan

    After more than a century of neglect, a profound revolution is occurring in the way archaeology addresses and interprets developments in the social history of early Islamic Syria-Palestine. This concise book offers an innovative assessment of social and economic developments in Syria-Palestine sh......After more than a century of neglect, a profound revolution is occurring in the way archaeology addresses and interprets developments in the social history of early Islamic Syria-Palestine. This concise book offers an innovative assessment of social and economic developments in Syria......-Palestine shortly before, and in the two centuries after, the Islamic expansion (the later sixth to the early ninth century AD), drawing on a wide range of new evidence from recent archaeological work. Alan Walmsley challenges conventional explanations for social change with the arrival of Islam, arguing...

  19. Appropriate technology: Often, the best answers can be found right ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-10-28

    Oct 28, 2010 ... In each case, however, the technologies have done their job – they have led to lasting solutions ... Appropriate technology: Often, the best answers can be found right at home ... In a Bookless Society, Why Start With Books?

  20. Protective mechanism against cancer found in progeria patient cells

    Science.gov (United States)

    NCI scientists have studied cells of patients with an extremely rare genetic disease that is characterized by drastic premature aging and discovered a new protective cellular mechanism against cancer. They found that cells from patients with Hutchinson Gi