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Bruno Dufaÿ
2006-05-01
Full Text Available Cette note présente les premiers résultats des fouilles menées en 2003 et 2004 sur la quasi-totalité du fort Saint-Georges à Chinon (Indre-et-Loire. Celui-ci est l’un des trois éléments de la forteresse médiévale qui domine la ville. La fouille a permis de préciser la fonction du fort, construit dans la deuxième moitié du XIIe s., à l’époque où Chinon est le centre administratif des possessions continentales des Plantagenêt, rois d’Angleterre. Du point de vue militaire, il formait une fortification avancée, protégeant le château principal, selon une structure que Richard Cœur de Lion appliquera au Château Gaillard. À l’intérieur, de vastes bâtiments constituaient des logis, conçus peut-être au départ pour héberger la chancellerie royale.This article presents the first results of the excavations undertaken in 2003 and 2004 over almost all of the Fort Saint-Georges at Chinon (Indre-et-Loire, one of three elements of the medieval fortress which dominates the town. The excavation enabled us to clarify the function of the fort, built in the 2nd half of the 12th century at a time when Chinon was the administrative centre of the continental possesions of the Plantagenet King of England. From a military point of view, it formed an advanced fortification protecting the main castle, within a structure that Richard the Lionheart would apply to the Chayeau Gaillard. Inside, some vast buildings made up the dwellings, designed perhaps initially to house the royal chanceller.
SAChES: Scalable Adaptive Chain-Ensemble Sampling.
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Swiler, Laura Painton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ray, Jaideep [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Ebeida, Mohamed Salah [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Huang, Maoyi [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hou, Zhangshuan [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bao, Jie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ren, Huiying [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
2017-08-01
We present the development of a parallel Markov Chain Monte Carlo (MCMC) method called SAChES, Scalable Adaptive Chain-Ensemble Sampling. This capability is targed to Bayesian calibration of com- putationally expensive simulation models. SAChES involves a hybrid of two methods: Differential Evo- lution Monte Carlo followed by Adaptive Metropolis. Both methods involve parallel chains. Differential evolution allows one to explore high-dimensional parameter spaces using loosely coupled (i.e., largely asynchronous) chains. Loose coupling allows the use of large chain ensembles, with far more chains than the number of parameters to explore. This reduces per-chain sampling burden, enables high-dimensional inversions and the use of computationally expensive forward models. The large number of chains can also ameliorate the impact of silent-errors, which may affect only a few chains. The chain ensemble can also be sampled to provide an initial condition when an aberrant chain is re-spawned. Adaptive Metropolis takes the best points from the differential evolution and efficiently hones in on the poste- rior density. The multitude of chains in SAChES is leveraged to (1) enable efficient exploration of the parameter space; and (2) ensure robustness to silent errors which may be unavoidable in extreme-scale computational platforms of the future. This report outlines SAChES, describes four papers that are the result of the project, and discusses some additional results.
The following organizations provide information on Tay-Sachs disease : US National Library of Medicine -- ghr.nlm.nih.gov/condition/tay-sachs-disease March of Dimes -- www.marchofdimes.org/complications/tay-sachs- ...
Tay-Sachs disease is a rare, inherited disease. It is a type of lipid metabolism disorder. It causes too ... cells, causing mental and physical problems. . Infants with Tay-Sachs disease appear to develop normally for the first few ...
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Ato Kwamena Tetteh
2017-12-01
Material and Methods ― The study was cross-sectional, involving 963 participants who consented to being screened for serum acetylcholinesterase (SAChE activity, using the dry chemistry test strips. The SAChE activity was then categorized into normal, low or high risk of developing symptoms associated with OP poisoning. Results ― The total group included 54.5% females and 45.5% males. Majority were crop farmers (46.3% and students/pupils (30.8%. The remaining 22.9% consisted mainly of traders, teachers, fishermen/fish processors, drivers and dressmakers. Very low SAChE activity unit of 30 U/ml. By this, a significant majority had either low or high risk of developing OP poisoning (χ2=4.43, 95%CI: 4.12–4.65, p=0.014 compared with those with normal activity. Most of the participants were in the 10–19 years age group of which 15.6% were in the high risk category, while 13.6% had low risk of OP poisoning. Reduced SAChE activity was predominant among all age groups compared with those with normal activity of the enzyme. As well, 27.3% who were females had reduced SAChE activity rate <30 U/ml (high risk of OP poisoning. Similarly, 23.4% of males were also at high risk of OP poisoning. There was however no statistical significance between the sex with regards to the numbers at risk of OP poisoning (χ2=4.80, 95% CI: 4.25–4.75, p=0.160. Conclusion ― This study provides some evidence of exposure, deduced from reduced SAChE activity, which potentially puts participants at a high risk of developing symptoms associated with OP poisoning. A follow-up study might be able to suggest to physicians in Ghana considering diagnostics of OP poisoning, especially for clients from farming communities where pesticides are used extensively.
Tallman, John F.; Johnson, William G.; Brady, Roscoe O.
1972-01-01
The catabolism of Tay-Sachs ganglioside, N-acetylgalactosaminyl- (N-acetylneuraminosyl) -galactosylglucosylceramide, has been studied in lysosomal preparations from normal human brain and brain obtained at biopsy from Tay-Sachs patients. Utilizing Tay-Sachs ganglioside labeled with 14C in the N-acetylgalactosaminyl portion or 3H in the N-acetylneuraminosyl portion, the catabolism of Tay-Sachs ganglioside may be initiated by either the removal of the molecule of N-acetylgalactosamine or N-acetylneuraminic acid. The activity of the N-acetylgalactosamine-cleaving enzyme (hexosaminidase) is drastically diminished in such preparations from Tay-Sachs brain whereas the activity of the N-acetylneuraminic acid-cleaving enzyme (neuraminidase) is at a normal level. Total hexosaminidase activity as measured with an artificial fluorogenic substrate is increased in tissues obtained from patients with the B variant form of Tay-Sachs disease and it is virtually absent in the O-variant patients. The addition of purified neuraminidase and various purified hexosaminidases exerted only a minimal synergistic effect on the hydrolysis of Tay-Sachs ganglioside in the lysosomal preparations from the control or patient with the O variant of Tay-Sachs disease. Images PMID:4639018
Ethical Issues with Genetic Testing for Tay-Sachs.
Clayton, Tricia
Several genetic disorders are specific to Jewish heritage; one of the most devastating is Tay-Sachs disease.Tay-Sachs is a fatal hereditary disease, causing progressive neurological problems for which there is no cure. Ethical issues surrounding genetic testing for Tay-Sachs within the Jewish community continue to be complex and multifaceted. A perspective of Tay-Sachs, using rights-based ethics and virtue ethics as a theoretical framework, is explored.
Prenatal Diagnosis Of Tay-Sachs Disease
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Özgür Özyüncü
2010-04-01
CONCLUSION: Tay-Sachs disease can be diagnosed prenatally by measuring hexosaminidase enzyme activity in fetal tissue samples with an acceptable complication rate. Prenatal diagnosis should be offered to families who have affected siblings with Tay-Sachs disease.
Energy in the Kantowski–Sachs space-time using teleparallel ...
Indian Academy of Sciences (India)
Energy in the Kantowski–Sachs space-time using teleparallel geometry ... Kantowski–Sachs metric; teleparallelism; gravitational energy. Abstract. The purpose of this paper is to examine the energy content of the inflationary Universe described by Kantowski–Sachs space-time in quasilocal approach of teleparallel gravity ...
Structural consequences of amino acid substitutions causing Tay-Sachs disease.
Ohno, Kazuki; Saito, Seiji; Sugawara, Kanako; Sakuraba, Hitoshi
2008-08-01
To determine the structural changes in the alpha-subunit of beta-hexosaminidase due to amino acid substitutions causing Tay-Sachs disease, we built structural models of mutant alpha-subunits resulting from 33 missense mutations (24 infantile and 9 late-onset), and analyzed the influence of each amino acid replacement on the structure by calculating the number of atoms affected and determining the solvent-accessible surface area of the corresponding amino acid residue in the wild-type alpha-subunit. In the infantile Tay-Sachs group, the number of atoms influenced by a mutation was generally larger than that in the late-onset Tay-Sachs group in both the main chain and the side chain, and residues associated with the mutations found in the infantile Tay-Sachs group tended to be less solvent-accessible than those in the late-onset Tay-Sachs group. Furthermore, color imaging determined the distribution and degree of the structural changes caused by representative amino acid substitutions, and that there were also differences between the infantile and late-onset Tay-Sachs disease groups. Structural study is useful for elucidating the basis of Tay-Sachs disease.
An inducible mouse model of late onset Tay-Sachs disease.
Jeyakumar, Mylvaganam; Smith, David; Eliott-Smith, Elena; Cortina-Borja, Mario; Reinkensmeier, Gabriele; Butters, Terry D; Lemm, Thorsten; Sandhoff, Konrad; Perry, V Hugh; Dwek, Raymond A; Platt, Frances M
2002-08-01
Mouse models of the G(M2) gangliosidoses, Tay-Sachs and Sandhoff disease, are null for the hexosaminidase alpha and beta subunits respectively. The Sandhoff (Hexb-/-) mouse has severe neurological disease and mimics the human infantile onset variant. However, the Tay-Sachs (Hexa-/-) mouse model lacks an overt phenotype as mice can partially bypass the blocked catabolic pathway and escape disease. We have investigated whether a subset of Tay-Sachs mice develop late onset disease. We have found that approximately 65% of the mice develop one or more clinical signs of the disease within their natural life span (n = 52, P disease at an earlier age (n = 21, P Tay-Sachs mice confirmed that pregnancy induces late onset Tay-Sachs disease. Onset of symptoms correlated with reduced up-regulation of hexosaminidase B, a component of the bypass pathway.
The National Tay Sachs and Allied Diseases Association.
Zeitlin, Paula
1986-01-01
The National Tay-Sachs and Allied Diseases Association is involved in education, research, and prevention of Tay-Sachs, an inherited metabolic disorder which destroys the central nervous system, and over 30 related disorders. The group features a parent peer group network and a support group for carrier couples. (CL)
National Tay-Sachs and Allied Diseases Association, Inc.
Exceptional Parent, 1977
1977-01-01
Reviewed are the history and organization, purpose and programs, and public services of the National Tay-Sachs and Allied Diseases Association, an organization geared toward eradicating Tay-Sachs disease (a hereditary disorder affecting primarily Jewish infants which generally leads to deterioration and death by the child's fifth year). (SBH)
[Tay-Sachs disease in non-Jewish infant in Israel].
Nadim, Nasser
2012-01-01
Tay-Sachs disease, also known as GM2 gangliosidosis or Hexosaminidase A deficiency is an autosomal recessive genetic fatal disorder. The disease is known to appear in East European Ashkenazi Jews, North African Jews, and Quebec French Canadians exclusively, but, with different frequency and type of mutation. Its most common variant is the infantile type Tay-Sachs disease. Juvenile and late-onset forms of the disease are infrequent and slowly progressive. At nearly 3 to 6 months old, a baby with Tay-Sachs progressively loses his motor skills and attentiveness. Startle responses and hyperreflexia become prominent, especially on eliciting deep patellar and Achilles reflexes, as a consequence of neurodegeneration of the upper motor neuron. Other systemic damage ensues gradually; seizures, blindness, spasticity of limbs, inability to swallow and breathe, and eventually the baby dies at 1-4 years of age. All Tay-Sachs patients have a "cherry red spot", easily seen in the macula area of the retina, using an ophthalmoscope. The "cherry red spot" is the only normal part of the retina in these sick babies. The case presented here emphasizes that Tay-Sachs disease is sometimes misdiagnosed at first visits even by an experienced clinician, because of his lack of awareness that this disease is not exclusively a Jewish disease.
Rapid detection of fetal Mendelian disorders: Tay-Sachs disease.
Guetta, Esther; Peleg, Leah
2008-01-01
Tay-Sachs disease is an autosomal recessive storage disease caused by the impaired activity of the lysosomal enzyme hexosaminidase A. In this fatal disease, the sphingolipid GM2 ganglioside accumulates in the neurons. Due to high carrier rates and the severity of the disease, population screening and prenatal diagnosis of Tay-Sachs disease are routinely carried out in Israel. Laboratory diagnosis of Tay-Sachs is carried out with biochemical and DNA-based methods in peripheral and umbilical cord blood, amniotic fluid, and chorionic villi samples. The assay of hexosaminidase A (Hex A) activity is carried out with synthetic substrates, 4-methylumbelliferyl-6-sulfo-N-acetyl-beta-glucosaminide (4-MUGS) and 4-methylumbelliferil-N-acetyl-beta-glucosamine (4-MUG), and the DNA-based analysis involves testing for the presence of specific known mutations in the alpha-subunit gene of Hex A. Prenatal diagnosis of Tay-Sachs disease is accomplished within 24-48 h from sampling. The preferred strategy is to simultaneously carry out enzymatic analysis in the amniotic fluid supernatant or in chorionic villi and molecular DNA-based testing in an amniotic fluid cell-pellet or in chorionic villi.
Tay-Sachs and Sandhoff Diseases
... more common in these groups: Creole of northern Argentina Metis Indians in Saskatchewan, Canada Lebanese If you or your partner is part of these ethnic groups, or you have a family history of Tay-Sachs disease or Sandhoff disease, tell ...
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Albia Josefina Pozo Alonso
Full Text Available La enfermedad de Tay-Sachs es un trastorno neurodegenerativo progresivo de herencia autosómica recesiva. Se debe a la deficiencia de la enzima β-hexosaminidasa A, que provoca una acumulación de gangliósidos GM2 en los lisosomas. Se incluye dentro de las esfingolipidosis. De las esfingolipidosis que presentan mancha rojo cereza en la mácula, la enfermedad de Tay-Sachs es la única en la que no se evidencia hepatoesplenomegalia. La variante más frecuente se inicia en la lactancia. Se presenta un lactante del sexo masculino al que se le realizó el diagnóstico de esta entidad a los 8 meses de edad. A partir de los 4 meses comenzó a presentar una reacción de sobresalto. A los 6 meses comenzó a perder habilidades previamente adquiridas y crisis epilépticas mioclónicas. Se constató una disminución de la actividad específica de la enzima hexosaminidasa A en leucocitos.
Proton MR spectroscopy in three children with Tay-Sachs disease.
Aydin, Kubilay; Bakir, Baris; Tatli, Burak; Terzibasioglu, Ege; Ozmen, Meral
2005-11-01
Tay-Sachs disease is an inherited metabolic disease caused by the accumulation of GM(2) gangliosides in the central nervous system. Deficiency of hexosaminidase A leads to the accumulation of gangliosides in neurons, axons and glial cells. To present the cranial MRI and proton MR spectroscopy findings of children of Tay-Sachs disease. Three children aged 10, 20 and 21 months were examined. On T2-weighted MR images there were hyperintense signal changes in the basal ganglia and cerebral white matter. MR spectroscopy demonstrated an increase in myoinositol/creatine and choline/creatine ratios with a decrease in the N-acetyl aspartate/creatine ratio. The spectroscopy findings support demyelination, gliosis and neuronal loss in the neuropathological process of Tay-Sachs disease.
Proton MR spectroscopy in three children with Tay-Sachs disease
Energy Technology Data Exchange (ETDEWEB)
Aydin, Kubilay; Bakir, Baris; Terzibasioglu, Ege [Istanbul University, Neuroradiology Division, Department of Radiology, Istanbul (Turkey); Tatli, Burak; Ozmen, Meral [Istanbul University, Department of Paediatric Neurology, Istanbul (Turkey)
2005-11-01
Tay-Sachs disease is an inherited metabolic disease caused by the accumulation of GM{sub 2} gangliosides in the central nervous system. Deficiency of hexosaminidase A leads to the accumulation of gangliosides in neurons, axons and glial cells. To present the cranial MRI and proton MR spectroscopy findings of children of Tay-Sachs disease. Three children aged 10, 20 and 21 months were examined. On T2-weighted MR images there were hyperintense signal changes in the basal ganglia and cerebral white matter. MR spectroscopy demonstrated an increase in myoinositol/creatine and choline/creatine ratios with a decrease in the N-acetyl aspartate/creatine ratio. The spectroscopy findings support demyelination, gliosis and neuronal loss in the neuropathological process of Tay-Sachs disease. (orig.)
Proton MR spectroscopy in three children with Tay-Sachs disease
International Nuclear Information System (INIS)
Aydin, Kubilay; Bakir, Baris; Terzibasioglu, Ege; Tatli, Burak; Ozmen, Meral
2005-01-01
Tay-Sachs disease is an inherited metabolic disease caused by the accumulation of GM 2 gangliosides in the central nervous system. Deficiency of hexosaminidase A leads to the accumulation of gangliosides in neurons, axons and glial cells. To present the cranial MRI and proton MR spectroscopy findings of children of Tay-Sachs disease. Three children aged 10, 20 and 21 months were examined. On T2-weighted MR images there were hyperintense signal changes in the basal ganglia and cerebral white matter. MR spectroscopy demonstrated an increase in myoinositol/creatine and choline/creatine ratios with a decrease in the N-acetyl aspartate/creatine ratio. The spectroscopy findings support demyelination, gliosis and neuronal loss in the neuropathological process of Tay-Sachs disease. (orig.)
A critique of Jeffrey D. Sachs's The end of poverty.
Henwood, Doug
2006-01-01
Jeffrey Sachs's The End of Poverty is a manifesto and how-to guide on ending extreme poverty around the world; it promotes the U.N. Millennium Development Goals. Sachs achieved fame with his policy package for the "stabilization" of Bolivia (which did nothing to relieve Bolivia's poverty), and became advisor to the Yeltsin government in Russia and to Poland, Slovenia, and Estonia as they began their transitions to capitalism (the last three mixed successes; Russia a thorough disaster). Sachs later became more prominent as a critic of development orthodoxy, and was economic advisor to the Jubilee 2000 movement. The End of Poverty is full of sharp critiques of Western imperialism, but his views on the rest of the development business are more conventional.
Effective gene therapy in an authentic model of Tay-Sachs-related diseases.
Cachón-González, M Begoña; Wang, Susan Z; Lynch, Andrew; Ziegler, Robin; Cheng, Seng H; Cox, Timothy M
2006-07-05
Tay-Sachs disease is a prototypic neurodegenerative disease. Lysosomal storage of GM2 ganglioside in Tay-Sachs and the related disorder, Sandhoff disease, is caused by deficiency of beta-hexosaminidase A, a heterodimeric protein. Tay-Sachs-related diseases (GM2 gangliosidoses) are incurable, but gene therapy has the potential for widespread correction of the underlying lysosomal defect by means of the secretion-recapture cellular pathway for enzymatic complementation. Sandhoff mice, lacking the beta-subunit of hexosaminidase, manifest many signs of classical human Tay-Sachs disease and, with an acute course, die before 20 weeks of age. We treated Sandhoff mice by stereotaxic intracranial inoculation of recombinant adeno-associated viral vectors encoding the complementing human beta-hexosaminidase alpha and beta subunit genes and elements, including an HIV tat sequence, to enhance protein expression and distribution. Animals survived for >1 year with sustained, widespread, and abundant enzyme delivery in the nervous system. Onset of the disease was delayed with preservation of motor function; inflammation and GM2 ganglioside storage in the brain and spinal cord was reduced. Gene delivery of beta-hexosaminidase A by using adeno-associated viral vectors has realistic potential for treating the human Tay-Sachs-related diseases.
Sachês antimicrobianos em pós-colheita de manga
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Eber Antonio Alves Medeiros
2011-10-01
Full Text Available Objetivou-se com este trabalho desenvolver sachês incorporados com óleos essenciais avaliando as propriedades físico-químicas e microbiológicas de mangas armazenadas em saco de papel contendo estes sachês em seu interior. Os óleos essenciais de orégano (Origanum vulgaris e capim-limão (Cymbopogon citratus foram incorporados em saches, e sua atividade antimicrobiana foi testada nos fungos Colletotrichum gloeosporides, Lasiodiplodia theobromae, Xanthomonas campestris pv. mangiferae indica, Alternaria alternata. Frutos de manga 'Tommy Atkins' foram acondicionados individualmente em sacos de papel contendo em seu interior um sachê antimicrobiano e mantidos a 25 °C ± 2 °C e UR 80% ± 5% por nove dias. Os parâmetros cor da epiderme, firmeza de polpa, sólidos solúveis, acidez titulável e pH sofreram pouca influência dos óleos essenciais de orégano e capim limão, indicando que a presença do óleo essencial não altera as características físico-químicas da polpa de manga. Os sachês ativos incorporados com óleos essenciais de orégano e capim limão apresentaram controle no crescimento dos microrganismos testados, sendo o capim-limão mais eficiente, reduzindo em aproximadamente 2 ciclos Log a contagem de mesófilos aeróbios e fungos filamentosos e leveduras em relação ao tratamento controle empregado.
'Cherry red spot' in a patient with Tay-Sachs disease: case report.
Aragão, Ricardo Evangelista Marrocos de; Ramos, Régia Maria Gondim; Pereira, Felipe Bezerra Alves; Bezerra, Andreya Ferreira Rodrigues; Fernandes, Daniel Nogueira
2009-01-01
Tay-Sachs disease is an autosomal recessive disorder of sphingolipid metabolism, caused by enzyme hexosaminidase A deficiency that leads to an accumulation of GM2 in neurocytes which results in progressive loss of neurological function. The accumulation of lipid in retinal ganglion cells that leads to a chalk-white appearance of the fundus called 'cherry red spot' is the hallmark of Tay-Sachs disease. It is also seen in others neurometabolic diseases as well as in central retinal artery occlusion. This case reports a child with Tay-Sachs disease in a family with four previous similar deaths without diagnostic.
Basic versus applied research: Julius Sachs (1832-1897) and the experimental physiology of plants.
Kutschera, Ulrich
2015-01-01
The German biologist Julius Sachs was the first to introduce controlled, accurate, quantitative experimentation into the botanical sciences, and is regarded as the founder of modern plant physiology. His seminal monograph Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) was published 150 y ago (1865), when Sachs was employed as a lecturer at the Agricultural Academy in Poppelsdorf/Bonn (now part of the University). This book marks the beginning of a new era of basic and applied plant science. In this contribution, I summarize the achievements of Sachs and outline his lasting legacy. In addition, I show that Sachs was one of the first biologists who integrated bacteria, which he considered to be descendants of fungi, into the botanical sciences and discussed their interaction with land plants (degradation of wood etc.). This "plant-microbe-view" of green organisms was extended and elaborated by the laboratory botanist Wilhelm Pfeffer (1845-1920), so that the term "Sachs-Pfeffer-Principle of Experimental Plant Research" appears to be appropriate to characterize this novel way of performing scientific studies on green, photoautotrophic organisms (embryophytes, algae, cyanobacteria).
Von Braun Rocket Team at Fort Bliss, Texas
1940-01-01
The German Rocket Team, also known as the Von Braun Rocket Team, poses for a group photograph at Fort Bliss, Texas. After World War II ended in 1945, Dr. Wernher von Braun led some 120 of his Peenemuende Colleagues, who developed the V-2 rocket for the German military during the War, to the United Sttes under a contract to the U.S. Army Corps as part of Operation Paperclip. During the following five years the team worked on high altitude firings of the captured V-2 rockets at the White Sands Missile Range in New Mexico, and a guided missile development unit at Fort Bliss, Texas. In April 1950, the group was transferred to the Army Ballistic Missile Agency (ABMA) at Redstone Arsenal in Huntsville, Alabama, and continued to work on the development of the guided missiles for the U.S. Army until transferring to a newly established field center of the National Aeronautic and Space Administration (NASA), George C. Marshall Space Flight Center (MSFC).
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Ricardo Evangelista Marrocos de Aragão
2009-08-01
Full Text Available Tay-Sachs disease is an autosomal recessive disorder of sphingolipid metabolism, caused by enzime hexosaminidase A deficiency that leads to an accumulation of GM2 in neurocytes which results in progressive loss of neurological function. The accumulation of lipid in retinal ganglion cells that leads to a chalk-white appearance of the fundus called "cherry red spot" is the hallmark of Tay-Sachs disease. It is also seen in others neurometabolic diseases as well as in central retinal artery occlusion. This case reports a child with Tay-Sachs disease in a family with four previous similar deaths without diagnostic.Tay-Sachs é uma doença autossômica recessiva, caracterizada pela deficiência da enzima hexosaminidase A levando ao acúmulo de esfingolipídios (GM2 em células neuronais que resulta em uma perda progressiva da função neurológica. O acúmulo de lipídios em células ganglionais da retina leva a uma aparência de mácula em cereja, característica do fundo de olho de pessoas acometidas. "Mácula em cereja" também pode ser vista em outras doenças neurometabólicas e em oclusão da artéria central da retina. Este trabalho relata o caso de um paciente com doença de Tay-Sachs em uma família com história de quatro óbitos por causas semelhantes sem diagnóstico.
CMB anisotropies at all orders: the non-linear Sachs-Wolfe formula
Roldan, Omar
2017-01-01
We obtain the non-linear generalization of the Sachs-Wolfe + integrated Sachs-Wolfe (ISW) formula describing the CMB temperature anisotropies. Our formula is valid at all orders in perturbation theory, is also valid in all gauges and includes scalar, vector and tensor modes. A direct consequence of our results is that the maps of the logarithmic temperature anisotropies are much cleaner than the usual CMB maps, because they automatically remove many secondary anisotropies. This can for instan...
Tay-Sach disease with "cherry-red spot"--first reported case in Malaysia.
Chan, L Y; Balasubramaniam, S; Sunder, R; Jamalia, R; Karunakar, T V N; Alagaratnam, J
2011-12-01
We present a rare case of Tay-Sachs disease with retinal 'cherry-red spots' in a 19-month-old Malay child. Molecular genetic studies confirmed the diagnosis. The case highlights that 'cherry-red spot' is a useful clinical clue in Tay-Sachs disease and several other lysosomal storage disorders. It serves as an ideal illustration of the eye as a window to inborn error of metabolism.
Tay Sachs and Related Storage Diseases: Family Planning
Schneiderman, Gerald; And Others
1978-01-01
Based on interviews with 24 families, the article discusses family planning and the choices available to those families in which a child has previously died from Tay-Sachs or related lipid storage diseases. (IM)
Segregation of Tay-Sachs and Sandhoff alleles in a non-Jewish family.
Lane, A B; Young, E; Jenkins, T
1980-01-01
A non-Jewish family is presented in which the genes for Tay-Sachs disease and Sandhoff disease are segregating. Individuals heterozygous for both alleles have low serum and white cell total hexosaminidase levels together with a proportion of heat-labile hexosaminidase A (HEX A) which falls in the normal range. The individuals would not be detected as carriers of Tay-Sachs disease or Sandhoff disease in a population screening program.
Distribution of a pseudodeficiency allele among Tay-Sachs carriers
Energy Technology Data Exchange (ETDEWEB)
Tomczak, J.; Grebner, E.E. (Thomas Jefferson Univ., Philadelphia, PA (United States)); Boogen, C. (Univ. of Essen Medical School (Germany))
1993-08-01
Recently Triggs-Raine et al. (1992) identified a new mutation in the gene coding for the [alpha]-subunit of [beta]-hexosaminidase A (hex A), the enzyme whose deficiency causes Tay-Sachs disease. This mutation, a C[sub 739]-to-T transition in exon 7, results in an altered enzyme that is active (albeit at reduced levels) in cells but that has essentially no activity in serum. This so-called pseudodeficient allele was first detected in compound heterozygotes who also carried a Tay-Sachs disease allele and therefore had no detectable hex A in their serum but who were in good health. Carriers of this apparently benign mutation are generally indistinguishable from carriers of a lethal mutation by means of routine enzyme-based screening tests, because the product of the pseudodeficient allele is not detectable in serum and has decreased activity in cells. This suggests that some individuals who have been classified as Tay-Sachs carriers are actually carriers of the pseudodeficient allele and are not at risk to have a child affected with Tay-Sachs disease. The pseudodeficient allele may also be responsible for some inconclusive diagnoses, where leukocyte values fall below the normal range but are still above the carrier range. The fact that there are now two mutant alleles (the psuedodeficient and the adult) that are indistinguishable from the lethal infantile mutations by means of enzyme assay yet that are phenotypically very different and that together may account for as much as 12% of enzyme-defined carriers on the basis of the data here suggests that DNA analysis should be part of a comprehensive screening program. It will be particularly useful to identify the mutations in couples at risk, before they undergo prenatal diagnosis. DNA analysis will also resolve some inconclusive diagnoses.
Outcomes of arthroscopic "Remplissage": capsulotenodesis of the engaging large Hill-Sachs lesion
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Mayo Lee
2011-06-01
Full Text Available Abstract Background A Hill-Sachs lesion of the humeral head after a shoulder dislocation is clinically insignificant in most cases. However, a sizable defect will engage with the anterior rim of the glenoid and cause instability even after anterior glenoid reconstruction. The purpose of this study was to evaluate the outcome of arthroscopic capsulotenodesis of the posterior capsule and infraspinatus tendon ("remplissage" to seal a large engaging Hill-Sachs lesion in an unstable shoulder. Methods This was a prospective follow-up study of patients who underwent arthroscopic surgery for recurrent shoulder instability with a large engaging Hill-Sachs lesion from 2007 to 2009. The clinical results were measured preoperatively and postoperatively with the Simple Shoulder test (SST and the Rowe score for instability. Results Eleven patients met the inclusion criteria of this study. The mean follow-up time was 30 months (range 24 to 35 months. At the last follow-up, significant improvement was observed in both scores with no recurrent dislocations. The mean SST improved from 6.6 to 11 (p Conclusions Arthroscopic remplissage for shoulder instability is an effective soft tissue technique to seal a large engaging Hill-Sachs lesion with respect to recurrence rate, range of motion and shoulder function.
Raffensperger, Jeff P.; Fleming, Brandon J.; Banks, William S.L.; Horn, Marilee A.; Nardi, Mark R.; Andreasen, David C.
2010-01-01
Increased groundwater withdrawals from confined aquifers in the Maryland Coastal Plain to supply anticipated growth at Fort George G. Meade (Fort Meade) and surrounding areas resulting from the Department of Defense Base Realignment and Closure Program may have adverse effects in the outcrop or near-outcrop areas. Specifically, increased pumping from the Potomac Group aquifers (principally the Patuxent aquifer) could potentially reduce base flow in small streams below rates necessary for healthy biological functioning. Additionally, water levels may be lowered near, or possibly below, the top of the aquifer within the confined-unconfined transition zone near the outcrop area. A three-dimensional groundwater flow model was created to incorporate and analyze data on water withdrawals, streamflow, and hydraulic head in the region. The model is based on an earlier model developed to assess the effects of future withdrawals from well fields in Anne Arundel County, Maryland and surrounding areas, and includes some of the same features, including model extent, boundary conditions, and vertical discretization (layering). The resolution (horizontal grid discretization) of the earlier model limited its ability to simulate the effects of withdrawals on the outcrop and near-outcrop areas. The model developed for this study included a block-shaped higher-resolution local grid, referred to as the child model, centered on Fort Meade, which was coupled to the coarser-grid parent model using the shared node Local Grid Refinement capability of MODFLOW-LGR. A more detailed stream network was incorporated into the child model. In addition, for part of the transient simulation period, stress periods were reduced in length from 1 year to 3 months, to allow for simulation of the effects of seasonally varying withdrawals and recharge on the groundwater-flow system and simulated streamflow. This required revision of the database on withdrawals and estimation of seasonal variations in
Segregation of Tay-Sachs and Sandhoff alleles in a non-Jewish family.
Lane, A B; Young, E; Jenkins, T
1980-01-01
A non-Jewish family is presented in which the genes for Tay-Sachs disease and Sandhoff disease are segregating. Individuals heterozygous for both alleles have low serum and white cell total hexosaminidase levels together with a proportion of heat-labile hexosaminidase A (HEX A) which falls in the normal range. The individuals would not be detected as carriers of Tay-Sachs disease or Sandhoff disease in a population screening program. PMID:7446530
Rozenberg, R; Pereira, L da V
2001-07-05
Tay-Sachs disease is an autosomal recessive disease characterized by progressive neurologic degeneration, fatal in early childhood. In the Ashkenazi Jewish population the disease incidence is about 1 in every 3,500 newborns and the carrier frequency is 1 in every 29 individuals. Carrier screening programs for Tay-Sachs disease have reduced disease incidence by 90% in high-risk populations in several countries. The Brazilian Jewish population is estimated at 90,000 individuals. Currently, there is no screening program for Tay-Sachs disease in this population. To evaluate the importance of a Tay-Sachs disease carrier screening program in the Brazilian Jewish population by determining the frequency of heterozygotes and the acceptance of the program by the community. Laboratory of Molecular Genetics--Institute of Biosciences--Universidade de São Paulo. 581 senior students from selected Jewish high schools. Molecular analysis of Tay-Sachs disease causing mutations by PCR amplification of genomic DNA, followed by restriction enzyme digestion. Among 581 students that attended educational classes, 404 (70%) elected to be tested for Tay-Sachs disease mutations. Of these, approximately 65% were of Ashkenazi Jewish origin. Eight carriers were detected corresponding to a carrier frequency of 1 in every 33 individuals in the Ashkenazi Jewish fraction of the sample. The frequency of Tay-Sachs disease carriers among the Ashkenazi Jewish population of Brazil is similar to that of other countries where carrier screening programs have led to a significant decrease in disease incidence. Therefore, it is justifiable to implement a Tay-Sachs disease carrier screening program for the Brazilian Jewish population.
Digital imaging of autoradiographs from paintings by Georges de La Tour (1593-1652)
Fischer, C O; Laurenze, C; Schmidt, C; Slusallek, K
1999-01-01
The artistic work of the painter Georges de La Tour has been studied very intensively in the last few years, mainly by French and US-American art historians and natural scientists. To support the in-depth analysis of two paintings from the Kimbell Art Museum in Fort Worth, Texas, USA, two similar paintings from the Gemaeldegalerie Berlin have been investigated. The method of neutron activation autoradiography has been applied using imaging plates with digital image processing.
The white matter of the human cerebrum: Part I The occipital lobe by Heinrich Sachs
Forkel, Stephanie J.; Mahmood, Sajedha; Vergani, Francesco; Catani, Marco
2015-01-01
This is the first complete translation of Heinrich Sachs' outstanding white matter atlas dedicated to the occipital lobe. This work is accompanied by a prologue by Prof Carl Wernicke who for many years was Sachs' mentor in Breslau and enthusiastically supported his work. PMID:25527430
Three-dimensional computed tomography measurement accuracy of varying Hill-Sachs lesion size.
Ho, Anthony; Kurdziel, Michael D; Koueiter, Denise M; Wiater, J Michael
2018-02-01
The glenoid track concept has been proposed to correlate shoulder stability with bone loss. Accurate assessment of Hill-Sachs lesion size preoperatively may affect surgical planning and postoperative outcomes; however, no measurement method has been universally accepted. This study aimed to assess the accuracy and reliability of measuring Hill-Sachs lesion sizes using 3-dimensional (3D) computed tomography (CT). Nine polyurethane humerus bone substitutes were used to create Hill-Sachs lesions of varying sizes with a combination of lesion depth (shallow, intermediate, and deep) and width (small, medium, and large). Specimens were scanned with a clinical CT scanner for size measurements and a micro-CT scanner for measurement of true lesion size. Six evaluators repeated measurements twice in a 2-week interval. Scans were measured by use of 3D CT reconstructions for length, width, and Hill-Sachs interval and with use of 2D CT for depth. The interclass correlation coefficient evaluated interobserver and intraobserver variability and percentage error, and Student t-tests assessed measurement accuracy. Interclass correlation coefficient reliability demonstrated strong agreement for all variables measured (0.856-0.975). Percentage error between measured length and measured depth and the true measurement significantly varied with respect to both lesion depth (P = .003 and P = .005, respectively) and lesion size (P = .049 and P = .004, respectively). The 3D CT imaging is effective and reproducible in determining lesion size. Determination of Hill-Sachs interval width is also reliable when it is applied to the glenoid track concept. Measured values on 3D and 2-dimensional imaging using a conventional CT scanner may slightly underestimate true measurements. Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.
[Sandhoff's and Tay-Sachs disease--based on our own cases].
Kokot, Witold; Raczyńska, Krystyna; Krajka-Lauer, Jarosława; Iwaszkiewicz-Bilikiewicz, Barbara; Wierzba, Jolanta
2004-01-01
The authors described two infant with Sandhoff's and Tay-Sachs disease. Tay-Sachs disease is well-known inherited disease leading to an accumulation of gangliosides in the brain and retina. Sandhoffs disease (GM2 gangliosidosis type 0) was diagnosed in an infant, in whom a progressive neurological disorder and cherry-red foveal spots were developed. In addition, to the general clinical examination, indirect ophthalnoscopy, blood white cells enzymatic examination are used to make definitive diagnosis. In this cases, the early eye fundus examination allowed us to make the proper diagnosis. The fundus change is characterized by the "cherry-red spot" in the central area.
Directory of Open Access Journals (Sweden)
Roberto Rozenberg
Full Text Available CONTEXT: Tay-Sachs disease is an autosomal recessive disease characterized by progressive neurologic degeneration, fatal in early childhood. In the Ashkenazi Jewish population the disease incidence is about 1 in every 3,500 newborns and the carrier frequency is 1 in every 29 individuals. Carrier screening programs for Tay-Sachs disease have reduced disease incidence by 90% in high-risk populations in several countries. The Brazilian Jewish population is estimated at 90,000 individuals. Currently, there is no screening program for Tay-Sachs disease in this population. OBJECTIVE: To evaluate the importance of a Tay-Sachs disease carrier screening program in the Brazilian Jewish population by determining the frequency of heterozygotes and the acceptance of the program by the community. SETTING: Laboratory of Molecular Genetics - Institute of Biosciences - Universidade de São Paulo. PARTICIPANTS: 581 senior students from selected Jewish high schools. PROCEDURE: Molecular analysis of Tay-Sachs disease causing mutations by PCR amplification of genomic DNA, followed by restriction enzyme digestion. RESULTS: Among 581 students that attended educational classes, 404 (70% elected to be tested for Tay-Sachs disease mutations. Of these, approximately 65% were of Ashkenazi Jewish origin. Eight carriers were detected corresponding to a carrier frequency of 1 in every 33 individuals in the Ashkenazi Jewish fraction of the sample. CONCLUSION: The frequency of Tay-Sachs disease carriers among the Ashkenazi Jewish population of Brazil is similar to that of other countries where carrier screening programs have led to a significant decrease in disease incidence. Therefore, it is justifiable to implement a Tay-Sachs disease carrier screening program for the Brazilian Jewish population.
Energy Technology Data Exchange (ETDEWEB)
Triggs-Raine, B.L.; Akerman, B.R.; Gravel, R.A. (McGill Univ.-Montreal Children' s Hospital Research Institute, Montreal, Quebec (Canada)); Mules, E.H.; Thomas, G.H.; Dowling, C.E. (Johns Hopkins School of Medicine, Baltimore, MD (United States)); Kaback, M.M.; Lim-Steele, J.S.T. (Univ. of California, San Diego, CA (United States)); Natowicz, M.R. (Eunice Kennedy Shriver Center for Mental Retardation, Waltham, MA (United States)); Grebner, E.E. (Thomas Jefferson Univ., Philadelphia, PA (United States)); Navon, R.R. (Tel-Aviv Univ., Kfar-Sava (Israel)); Welch, J.P. (Dalhousie Univ., Halifax, Nova, Scotia (Canada)); Greenberg, C.R. (Univ. of Manitoba, Winnipeg (Canada))
1992-10-01
Deficiency of [beta]-hexosaminidase A (Hex A) activity typically results in Tay-Sachs disease. However, healthy subjects found to be deficient in Hex A activity (i.e., pseudodeficient) by means of in vitro biochemical tests have been described. The authors analyzed the HEXA gene of one pseudodeficient subject and identified both a C[sub 739]-to-T substitution that changes Arg[sub 247][yields]Trp on one allele and a previously identified Tay-Sachs disease mutation of the second allele. Six additional pseudodeficient subjects were found to have the C[sub 739]-to-T but for none of 36 Jewish enzyme-defined carries who did not have one of three known mutations common to this group. The C[sub 739]-to-T allele, together with a [open quotes]true[close quotes] Tay-Sachs disease allele, causes Hex A pseudodeficiency. Given both the large proportion of non-Jewish carriers with this allele and that standard biochemical screening cannot differentiate between heterozygotes for the C[sub 739]-to-T mutations and Tay-Sachs disease carriers, DNA testing for this mutation in at-risk couples is essential. This could prevent unnecessary or incorrect prenatal diagnoses. 40 refs., 3 figs., 4 tabs.
The white matter of the human cerebrum: part I The occipital lobe by Heinrich Sachs.
Forkel, Stephanie J; Mahmood, Sajedha; Vergani, Francesco; Catani, Marco
2015-01-01
This is the first complete translation of Heinrich Sachs' outstanding white matter atlas dedicated to the occipital lobe. This work is accompanied by a prologue by Prof Carl Wernicke who for many years was Sachs' mentor in Breslau and enthusiastically supported his work. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
Investigation on Adaptive Re-use of Heritage Building in George Town, Penang
Directory of Open Access Journals (Sweden)
Marhamah Abdul Hadi
2013-09-01
Full Text Available Adaptive re-use of heritage buildings in George Town has gained attention from their owners. Their owners either private owners or government, want to adapt their respective buildings to new usage for instance to become a gallery, museum, restaurant, boutique hotel and many more. Every heritage building that is being adapted to paper main objective is to identify the changes made in terms of structure, space and material when adapting the heritage buildings to a new usage specifically into a gallery. Two heritage buildings are chosen as case studies for this paper which are Rumah Teh Bunga and Fort Cornwallis; both buildings located in Penang, Malaysia. The changes made to these two buildings were analyzed using the guidelines provided which are Guideline for Conservation areas and Heritage Buildings and National Heritage Acts 2005. Both buildings will be analyzed using National Heritage Acts, while only Fort Cornwallis will be analyzed using Guideline for Conservation areas and Heritage Buildings. Adaptation of these two heritage buildings requires changes in structure, space and material. The changes in Rumah Teh Bunga focuses more on materials and space while changes in Fort Cornwallis emphasize more to space and addition of other structures. Analysis on the changes are made by using the guideline provided, most of the changes made to both of these heritage buildings comply the rules and regulations stated in the guideline. It was found from the data that some of the reasons on why the owner change Rumah Teh Bunga to gallery are because of its complicated procedure that involves in privatization of this building to other owner and the need to promote the heritage significance of this building to the public. As for Fort Cornwallis, the adaptation is more on strengthening its value as a fort and becoming a tourist attraction.
Planck 2015 results: XXI. The integrated Sachs-Wolfe effect
DEFF Research Database (Denmark)
Ade, P. A R; Aghanim, N.; Arnaud, M.
2016-01-01
This paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives....
CMB anisotropies at all orders: the non-linear Sachs-Wolfe formula
International Nuclear Information System (INIS)
Roldan, Omar
2017-01-01
We obtain the non-linear generalization of the Sachs-Wolfe + integrated Sachs-Wolfe (ISW) formula describing the CMB temperature anisotropies. Our formula is valid at all orders in perturbation theory, is also valid in all gauges and includes scalar, vector and tensor modes. A direct consequence of our results is that the maps of the logarithmic temperature anisotropies are much cleaner than the usual CMB maps, because they automatically remove many secondary anisotropies. This can for instance, facilitate the search for primordial non-Gaussianity in future works. It also disentangles the non-linear ISW from other effects. Finally, we provide a method which can iteratively be used to obtain the lensing solution at the desired order.
CMB anisotropies at all orders: the non-linear Sachs-Wolfe formula
Energy Technology Data Exchange (ETDEWEB)
Roldan, Omar, E-mail: oaroldan@if.ufrj.br [Instituto de Física, Universidade Federal do Rio de Janeiro, 21941-972, Rio de Janeiro, RJ (Brazil)
2017-08-01
We obtain the non-linear generalization of the Sachs-Wolfe + integrated Sachs-Wolfe (ISW) formula describing the CMB temperature anisotropies. Our formula is valid at all orders in perturbation theory, is also valid in all gauges and includes scalar, vector and tensor modes. A direct consequence of our results is that the maps of the logarithmic temperature anisotropies are much cleaner than the usual CMB maps, because they automatically remove many secondary anisotropies. This can for instance, facilitate the search for primordial non-Gaussianity in future works. It also disentangles the non-linear ISW from other effects. Finally, we provide a method which can iteratively be used to obtain the lensing solution at the desired order.
DEFF Research Database (Denmark)
Hejlsted, Annemette
Fortællingen - teori og analyse introducerer til teorier om fortællingen og præsenterer et sæt af analytiske tilgange til fortællinger af enhver art. Bogen lægger vægt på læsersynsvinklen og retter opmærksomheden mod de vilkår for menings- og betydningsdannelse, der kendetegner fortællingen. Begr....... Begreber om plot, fortællingens verden, karakterer, fortæller, modus og genre behandles, og deres anvendelse demonstreres på dansk og nordisk litteratur - med inddragelse af eksempler fra film og tv-reklamer....
Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.
Kodama, Takashi; Togawa, Tadayasu; Tsukimura, Takahiro; Kawashima, Ikuo; Matsuoka, Kazuhiko; Kitakaze, Keisuke; Tsuji, Daisuke; Itoh, Kohji; Ishida, Yo-Ichi; Suzuki, Minoru; Suzuki, Toshihiro; Sakuraba, Hitoshi
2011-01-01
To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2) levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex) B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease.
Tay Sachs disease: an autopsy case report.
Jadhav, Meenal Vitthal; Landge, Meenal P; Sawaimoon, Satyakam K; Harke, Arun B; Deshmukh, Sanjay D
2005-10-01
This report describes a case report of a postmortem performed on a 5-year old patient of Tay-Sachs disease, presenting with failure to thrive, muscular flaccidity, and cherry-red spots on macula on fundoscopy. There was no history of similarly affected sibling or any other family member. The diagnosis was confirmed by enzyme studies. At postmortem, there was no organomegaly. The brain, on microscopy, showed vacuolated swollen neurons.
Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.
Directory of Open Access Journals (Sweden)
Takashi Kodama
Full Text Available To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2 levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease.
Quantum field theory of the universe in the Kantowski-Sachs space-time
International Nuclear Information System (INIS)
Shen, Y.; Tan, Z.
1996-01-01
In this paper, the quantum field theory of the universe in the Kantowski-Sachs space-time is studied. An analogue of proceedings in quantum field theory is applied in curved space-time to the Kantowski-Sachs space-time, obtaining the wave function of the universe satisfied the Wheeler-DeWitt equation. Regarding the wave function as a universe field in the minisuperspace, the authors can not only overcome the difficulty of the probabilistic interpretation in quantum cosmology, but also come to the conclusion that there is multiple production of universes. The average number of the produced universes from nothing is calculated. The distribution of created universe is given. It is the Planckian distribution
Energy in the Kantowski–Sachs space-time using teleparallel ...
Indian Academy of Sciences (India)
Inflation is again considered to be one of the early phases of the Universe [10]. For testing gravitational energy–momentum tensor of the teleparallel theory in quasilocal approach and also in the. Hamiltonian structure of TEGR, it is intended to calculate the total energy of inflationary. Kantowski–Sachs-type Universe. Again ...
Nakamura, Sadao; Saito, Yoshiaki; Ishiyama, Akihiko; Sugai, Kenji; Iso, Takashi; Inagaki, Masumi; Sasaki, Masayuki
2015-01-01
To clarify the evolution of an augmented startle reflex in Tay-Sachs disease and compare the temporal relationship between this reflex and brainstem evoked potentials. Clinical and electrophysiological data from 3 patients with Tay-Sachs disease were retrospectively collected. The augmented startle reflex appeared between the age of 3 and 17 months and disappeared between the age of 4 and 6 years. Analysis of brainstem auditory evoked potentials revealed that poor segregation of peak I, but not peak III, coincided with the disappearance of the augmented startle reflex. A blink reflex with markedly high amplitude was observed in a patient with an augmented startle reflex. The correlation between the augmented startle reflex and the preservation of peak I but not peak III supports the theory that the superior olivary nucleus is dispensable for this reflex. The blink reflex with high amplitudes may represent augmented excitability of reticular formation at the pontine tegmentum in Tay-Sachs disease, where the pattern generators for the augmented startle and blink reflexes may functionally overlap. Copyright © 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
International Nuclear Information System (INIS)
Portugal, R.
1984-01-01
Three processes of solutions of the Einstein-Maxwell equations for Bianchi - I, II, VIII, IX and Kantowski-Sachs-like cosmological models with perfect fluid in magnetohydrolodynamical regimem are presented. Diagonal Bianchi-like models are considered with two anisotropy direction in the maximum. Solutions are found for Bianchi-II and IX-like models with energy conditions to be analyzed. Solutions are found for Bianchi-IX and Kantowski-Sachs-Like models with positive electric conductivity and satisfering to the predominant energy conditions. Solutions are formed for isotropic Kantowski-Sachs-Like models satisfering to the equation of state p=λρ, 0 0, admiting, in addition to the perfect fluid, electric field only. It is shown that a class of Bertotti-Robinson-like solutions is unstable by perturbations and it is carried in Kantowski-Sachs-like models with non-null electric conductivity. (L.C.) [pt
Gravitational, shear and matter waves in Kantowski-Sachs cosmologies
Energy Technology Data Exchange (ETDEWEB)
Keresztes, Zoltán; Gergely, László Á. [Department of Theoretical Physics, University of Szeged, Tisza Lajos krt 84-86, Szeged 6720 (Hungary); Forsberg, Mats; Bradley, Michael [Department of Physics, UmeåUniversity (Sweden); Dunsby, Peter K.S., E-mail: zkeresztes@titan.physx.u-szeged.hu, E-mail: forsberg.mats.a.b@gmail.com, E-mail: michael.bradley@physics.umu.se, E-mail: peter.dunsby@uct.ac.za, E-mail: gergely@physx.u-szeged.hu [Astrophysics, Cosmology and Gravity Centre (ACGC), University of Cape Town, Rondebosch 7701, Cape Town (South Africa)
2015-11-01
A general treatment of vorticity-free, perfect fluid perturbations of Kantowski-Sachs models with a positive cosmological constant are considered within the framework of the 1+1+2 covariant decomposition of spacetime. The dynamics is encompassed in six evolution equations for six harmonic coefficients, describing gravito-magnetic, kinematic and matter perturbations, while a set of algebraic expressions determine the rest of the variables. The six equations further decouple into a set of four equations sourced by the perfect fluid, representing forced oscillations and two uncoupled damped oscillator equations. The two gravitational degrees of freedom are represented by pairs of gravito-magnetic perturbations. In contrast with the Friedmann case one of them is coupled to the matter density perturbations, becoming decoupled only in the geometrical optics limit. In this approximation, the even and odd tensorial perturbations of the Weyl tensor evolve as gravitational waves on the anisotropic Kantowski-Sachs background, while the modes describing the shear and the matter density gradient are out of phase dephased by π /2 and share the same speed of sound.
Neurocognitive testing in late-onset Tay-Sachs disease: a pilot study.
Elstein, D; Doniger, G M; Simon, E; Korn-Lubetzki, I; Navon, R; Zimran, A
2008-08-01
To test neurocognitive function in patients with late-onset Tay-Sachs disease (LOTS) using a computerized system to assess whether cognition is a clinically relevant outcome measure of possible therapeutic intervention in LOTS. Ten adults with Tay-Sachs disease were administered at least one battery of the Mindstreams Neurotrax system for evaluation of cognitive function. Six sub-scores and a Global Cognitive Score (GCS) were tabulated. A disease specific severity score was also devised with six domains. Despite identical genotypes, all patients but the two oldest had > or = 3/6 sub-scores one standard deviation below normal mean (100); verbal and executive functions were most affected. The severity score measured other functions. Because of provocative findings on re-testing in patients exposed to miglustat, and despite the very small cohort, cognitive function may be an appropriate and clinically relevant outcome measure for future therapeutic interventions in LOTS.
1971-10-01
Jack and Bobby Kennedy, Jim Plunkett, George Jackson, the Beatles , Janice Joplin, and the growing number of men who have walked on the moon. It...Executive Summary as an Interim Re- port on the CONARC Training Workshop, which was held 5-7 October 1971 at Fort Gordon, Georgia. 3. The report will be...volume will be sent to each addressee to form two complete sets of the report. Requests for additional copies of the separate volumes will be filled
Tay-Sachs disease with conspicuous cranial computerized tomographic appearances
International Nuclear Information System (INIS)
Watanabe, Kishichiro; Mukawa, Akio; Muto, Kazuhiko; Nishikawa, Jiro; Takahashi, Shigeko.
1985-01-01
An autopsy case of a 3-year-old female infant with Tay-Sachs disease was presented. A cherry red spot in the fundus and a deficiency of N-acetyl-β-hexosaminidase A in the white blood cells were revealed soon after admission at the age of one year. Her parents and sister were found to be healthy carriers. The patient showed a typical clinical course with marked cranial swelling. In addition to the marked ballooning of neurons on light microscope, membranous cytoplasmic body (MCB) on electron microscope and abnormal accumulation of GM 2 ganglioside in the cerebral cortex by thin layer chromatography were confirmed in the autopsy specimens. In the late stage of her clinical course, the cranial computerized tomography (CT) demonstrated symmetric and deep-wavy hyperdense cerebral cortical zones, diffuse hypodensity and diminished volume of cerebral white matter, mild to moderate ventricular dilatation, and a small cerebellum and brainstem. These conspicuous appearances of the cranial CT seem to be characteristic of Tay-Sachs disease in the late stage, and they are derived from abnormal accumulation of GM 2 ganglioside in the cerebral cortex, and diffuse intense demyelination (dysmyelinating demyelination) of the cerebral white matter. (author)
Choroidal Coloboma in a Case of Tay-Sachs Disease
Ahmed, Nasreen Raees; Tripathy, Koushik; Kumar, Vivek; Gogia, Varun
2014-01-01
Coloboma as an ocular finding has been documented in various syndromes. Here we have a case of infantile Tay-Sachs disease associated with unilateral choroidal coloboma. To the best of our knowledge, such an association has not been documented in the literature. Whether such an association is a matter of chance or signifies the involvement of ganglioside metabolism in ocular embryogenesis remains to be elucidated.
Choroidal coloboma in a case of tay-sachs disease.
Ahmed, Nasreen Raees; Tripathy, Koushik; Kumar, Vivek; Gogia, Varun
2014-01-01
Coloboma as an ocular finding has been documented in various syndromes. Here we have a case of infantile Tay-Sachs disease associated with unilateral choroidal coloboma. To the best of our knowledge, such an association has not been documented in the literature. Whether such an association is a matter of chance or signifies the involvement of ganglioside metabolism in ocular embryogenesis remains to be elucidated.
Chamoles, Néstor A; Blanco, Mariana; Gaggioli, Daniela; Casentini, Carina
2002-04-01
Tay-Sachs disease (TSD), Sandhoff disease (SD) and variants are caused by deficient activity of the lysosomal enzymes hexosaminidase A (HA) and total hexosaminidase (TH) (hexosaminidase A plus B), respectively. For diagnosis, these enzymes are usually measured in plasma or extracts of leukocytes. We describe methods for the assay of hexosaminidase A and total hexosaminidase activities in dried blood spots (DBSs) on filter paper. We studied 163 healthy controls, 9 Tay-Sachs patients, 4 Sandhoff patients, 18 obligate carriers and the newborn-screening cards from two patients with Tay-Sachs and one patient with Sandhoff disease. To tubes containing a 3-mm-diameter blood spot, we added elution liquid and substrate solution. After incubation at 37 degrees C, the amount of hydrolyzed product was compared with a calibrator to allow the quantification of enzyme activity. The described methodology is useful to distinguish patients with Tay-Sachs disease or Sandhoff disease from carriers and controls using samples that are sufficiently stable to be transported to the testing laboratory by mail. The diagnosis of both diseases from a newborn-screening card (NSC) was clearly demonstrated, even after storage for up to 38 months at room temperature. The newborn-screening card has been added to the biological materials that allow the identification of patients with Tay-Sachs disease and Sandhoff disease.
Hussein, Norita; Weng, Stephen F; Kai, Joe; Kleijnen, Jos; Qureshi, Nadeem
2018-03-14
Globally, about five per cent of children are born with congenital or genetic disorders. The most common autosomal recessive conditions are thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease, with higher carrier rates in specific patient populations. Identifying and counselling couples at genetic risk of the conditions before pregnancy enables them to make fully informed reproductive decisions, with some of these choices not being available if genetic counselling is only offered in an antenatal setting. This is an update of a previously published review. To assess the effectiveness of systematic preconception genetic risk assessment to improve reproductive outcomes in women and their partners who are identified as carriers of thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease in healthcare settings when compared to usual care. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Registers. In addition, we searched for all relevant trials from 1970 (or the date at which the database was first available if after 1970) to date using electronic databases (MEDLINE, Embase, CINAHL, PsycINFO), clinical trial databases (National Institutes of Health, Clinical Trials Search portal of the World Health Organization, metaRegister of controlled clinical trials), and hand searching of key journals and conference abstract books from 1998 to date (European Journal of Human Genetics, Genetics in Medicine, Journal of Community Genetics). We also searched the reference lists of relevant articles, reviews and guidelines and also contacted subject experts in the field to request any unpublished or other published trials.Date of latest search of the registers: 20 June 2017.Date of latest search of all other sources: 16 November 2017. Any randomised or quasi-randomised controlled trials (published or unpublished) comparing reproductive outcomes of systematic preconception genetic risk assessment for thalassaemia, sickle
İki Kardeşte Görülen Tay-Sachs Hastalığı
KÜÇÜKÖDÜK, Ş.
2010-01-01
In view of two cases of autosomal recessive Tay-Sachs disease which affected two siblings, genetic consultation has been once more emphasized. The clinical features of this entity has been reviewed under the information obtained from recent literature. Otozomal resesif geçiş gösteren ve iki kardeşide etkiliyen Tay-Sachs hastalığında, genetik danışmanın önemi bir kez daha vurgulandı. Bu hastalığın klinik özellikleri literatür bilgilerinin ışığı altında gözden geçirildi....
Tay-Sachs disease: high gene frequency in a non-Jewish population.
Kelly, T E; Chase, G A; Kaback, M M; Kumor, K; McKusick, V A
1975-01-01
A non-Amish "Pennsylvania Dutch" semi-isolate was found to have a high frequency of Tay-Sachs gene. This high frequency could be ascribed to founder effect and may represent, in microcosm, how this mechanism could have produced the high gene frequency among Ashkenazi Jews. PMID:803011
78 FR 24447 - Goldman Sachs Trust, et al.; Notice of Application
2013-04-25
... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30471; 812-14075] Goldman Sachs Trust, et al.; Notice of Application April 19, 2013. AGENCY: Securities and Exchange Commission..., or cause more than 10% of the acquired company's voting stock to be owned by investment companies and...
Diagnosis and molecular characterization of non-classic forms of Tay-Sachs disease in Brazil.
Rozenberg, R; Kok, F; Burin, M G; Sá Miranda, M C; Vasques, C; Henriques-Souza, A M M; Giugliani, R; Vainzof, Mariz; Pereira, L V
2006-06-01
Molecular analysis of five Brazilian families, including eight patients presenting with nonclassic Tay-Sachs disease, was performed to identify frequent causative mutations and their correlation with clinical course. Three patients were affected by the B1 subacute variant and were shown to carry the R178H mutation (the DN allele), which is also common among Portuguese patients. Two of them were compound heterozygotes, whereas the third presented with the mutation in both alleles. Since Brazil was a Portuguese colony for over two centuries, common ancestry might be the probable explanation. The fourth patient presented with a juvenile phenotype and carries the R499H mutation, which has been reported only once worldwide and is associated with residual enzyme activity, responsible for a slower clinical course. The fifth family, of an Ashkenazi Jewish background, showed an extensive intrafamilial clinical variability among three affected sibs presenting with muscle atrophy, ataxia, and psychiatric symptoms. They were first diagnosed as having atypical spinal muscular atrophy and, subsequently, spinocerebellar ataxia, but, recently, the diagnosis of late-onset Tay-Sachs disease was confirmed based on reduced plasma hexosaminidase A activity and the G269S/InsTATC1278 genotype. It is therefore highly recommended to test patients with a similar clinical history for Tay-Sachs disease. In the same family, one first cousin committed suicide at the age of 24 years, presenting with a clinical phenotype that suggested an undiagnosed case and highlighting the effect of the intrafamilial clinical variability in delaying a prompt diagnosis. It is now recognized that his parents are, in fact, a carrier couple. Additionally, another relative had been previously identified as a heterozygote in a Tay-Sachs disease screening program, but the information was not shared among the family. Since this information might anticipate diagnosis and genetic counseling, it is advisable that
Choroidal Coloboma in a Case of Tay-Sachs Disease
Directory of Open Access Journals (Sweden)
Nasreen Raees Ahmed
2014-01-01
Full Text Available Coloboma as an ocular finding has been documented in various syndromes. Here we have a case of infantile Tay-Sachs disease associated with unilateral choroidal coloboma. To the best of our knowledge, such an association has not been documented in the literature. Whether such an association is a matter of chance or signifies the involvement of ganglioside metabolism in ocular embryogenesis remains to be elucidated.
International Nuclear Information System (INIS)
Myerowitz, R.
1988-01-01
Tay-Sachs disease is an inherited disorder in which the α chain of the lysosomal enzyme β-N-acetylhexosaminidase A bears the mutation. Ashkenazi Jews are found to be carriers for a severe type of Tay-Sachs disease, the classic form, 10 times more frequently than the general population. Ashkenazi Jewish patients with classic Tay-Sachs disease have appeared to be clinically and biochemically identical, and the usual assumption has been that they harbor the same α-chain mutation. The author has isolated the α-chain gene from an Ashkenazi Jewish patient, GM2968, with classic Tay-Sachs disease and compared its nucleotide sequences with that of the normal α-chain gene in the promoter region, exon and splice junction regions, and polyadenylylation signal area. Only one difference was observed between these sequences. The alteration is presumed to be functionally significant and to result in aberrant mRNA splicing. Utilizing the polymerase chain reaction to amplify the region encompassing the mutation, the author developed an assay to screen patients and heterozygote carriers for this mutation. Surprisingly, in each of two Ashkenazi patients, only one α-chain allele harbored the splice junction mutation. Only one parent of each of these patients was positive for the defect. Another Ashkenazi patient did not bear this mutation at all nor did either of the subject's parents. The data are consistent with the presence of more than one mutation underlying the classic form of Tay-Sachs disease in the Ashkenazi Jewish population
Energy Technology Data Exchange (ETDEWEB)
Myerowitz, R. (National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD (USA))
1988-06-01
Tay-Sachs disease is an inherited disorder in which the {alpha} chain of the lysosomal enzyme {beta}-N-acetylhexosaminidase A bears the mutation. Ashkenazi Jews are found to be carriers for a severe type of Tay-Sachs disease, the classic form, 10 times more frequently than the general population. Ashkenazi Jewish patients with classic Tay-Sachs disease have appeared to be clinically and biochemically identical, and the usual assumption has been that they harbor the same {alpha}-chain mutation. The author has isolated the {alpha}-chain gene from an Ashkenazi Jewish patient, GM2968, with classic Tay-Sachs disease and compared its nucleotide sequences with that of the normal {alpha}-chain gene in the promoter region, exon and splice junction regions, and polyadenylylation signal area. Only one difference was observed between these sequences. The alteration is presumed to be functionally significant and to result in aberrant mRNA splicing. Utilizing the polymerase chain reaction to amplify the region encompassing the mutation, the author developed an assay to screen patients and heterozygote carriers for this mutation. Surprisingly, in each of two Ashkenazi patients, only one {alpha}-chain allele harbored the splice junction mutation. Only one parent of each of these patients was positive for the defect. Another Ashkenazi patient did not bear this mutation at all nor did either of the subject's parents. The data are consistent with the presence of more than one mutation underlying the classic form of Tay-Sachs disease in the Ashkenazi Jewish population.
Role of the physician in screening for carriers of Tay-Sachs disease.
Lowden, J. A.
1978-01-01
A screening test for carriers of Tay-Sachs disease has been available in Toronto for more than 6 years. In that time more than 11 000 Jewish residents have been tested. Most had requested testing after hearing about the screening program from friends or the media; few had been advised by their physicians to be tested. To sample the attitudes of physicians in Toronto towards carrier screening, we studied questionnaire responses of 42 physicians whose practices were composed largely of Jewish patients. Only 31% regularly advised their young adult Jewish patients to have a carrier screening test but 76% said they had patients who asked if they should be tested. Of the 14 (33%) who had had one or more patients with Tay-Sachs disease 6 did not advise carrier testing. There was a positive correlation between specialty training and support for the screening program. Methods for increasing physician advocacy of these programs are discussed. PMID:709448
Kantowski--Sachs cosmological models as big-bang models
International Nuclear Information System (INIS)
Weber, E.
1985-01-01
In the presence of a nonzero cosmological constant Λ, we classify the anisotropic cosmological models of the Kantowski--Sachs type by means of the quantities epsilon 2 0 , q 0 , summation 0 corresponding, respectively, to the relative root-mean-square deviation from isotropy, the deceleration parameter, and the density parameter of the perfect fluid at a given time t = t 0 . We obtain for Λ>0 a set of big-bang models of zero measure as well as a set of cosmological models of nonzero measure evolving toward the de Sitter solution
Black Hole Entropy from Bondi-Metzner-Sachs Symmetry at the Horizon.
Carlip, S
2018-03-09
Near the horizon, the obvious symmetries of a black hole spacetime-the horizon-preserving diffeomorphisms-are enhanced to a larger symmetry group with a three-dimensional Bondi-Metzner-Sachs algebra. Using dimensional reduction and covariant phase space techniques, I investigate this augmented symmetry and show that it is strong enough to determine the black hole entropy in any dimension.
Rapid identification of HEXA mutations in Tay-Sachs patients.
Giraud, Carole; Dussau, Jeanne; Azouguene, Emilie; Feillet, François; Puech, Jean-Philippe; Caillaud, Catherine
2010-02-19
Tay-Sachs disease (TSD) is a recessively inherited neurodegenerative disorder due to mutations in the HEXA gene resulting in a beta-hexosaminidase A (Hex A) deficiency. The purpose of this study was to characterize the molecular abnormalities in patients with infantile or later-onset forms of the disease. The complete sequencing of the 14 exons and flanking regions of the HEXA gene was performed with a unique technical condition in 10 unrelated TSD patients. Eleven mutations were identified, including five splice mutations, one insertion, two deletions and three single-base substitutions. Four mutations were novel: two splice mutations (IVS8+5G>A, IVS2+4delAGTA), one missense mutation in exon 6 (c.621T>G (p.D207E)) and one small deletion (c.1211-1212delTG) in exon 11 resulting in a premature stop codon at residue 429. The c.621T>G missense mutation was found in a patient presenting an infantile form. Its putative role in the pathogenesis of TSD is suspected as residue 207 is highly conserved in human, mouse and rat. Moreover, structural modelling predicted changes likely to affect substrate binding and catalytic activity of the enzyme. The time-saving procedure reported here could be useful for the characterization of Tay-Sachs-causing mutations, in particular in non-Ashkenazi patients mainly exhibiting rare mutations. Copyright (c) 2010 Elsevier Inc. All rights reserved.
Late-onset Tay-Sachs disease: adverse effects of medications and implications for treatment.
Shapiro, B E; Hatters-Friedman, S; Fernandes-Filho, J A; Anthony, K; Natowicz, M R
2006-09-12
The authors conducted a retrospective and brief prospective study of adverse effects of approximately 350 medications in 44 adults with late-onset Tay-Sachs disease (LOTS). Some medications were relatively safe, whereas others, particularly haloperidol, risperidone, and chlorpromazine, were associated with neurologic worsening.
Udwadia-Hegde, Anaita; Hajirnis, Omkar
2017-01-01
Juvenile Tay-Sachs disease is rarer than other forms of Tay-Sachs disease and is usually seen in children between the age of 2 and 10 years. Pyrimethamine as a pharmacological chaperone was used to increase β-hexosaminidase A activity in this patient. We describe a patient with Tay-Sachs disease from the Indian population, a juvenile case who presented with developmental regression starting at the age of three, initially with motor followed by language regression. She is currently incapacitated with severe behavioral issues. This brief communication gives an insight into the efficacy of pharmacological chaperones. It also describes two unreported mutations in hexosaminidase A gene from the Indian population. After commencing Pyrimethamine, though initial benefits with increase in levels corresponded with briefly halting the motor regression, the observed increase was only transient and not associated with discernible beneficial neurological or psychiatric effects.
DEFF Research Database (Denmark)
Larsen, Gorm
2012-01-01
Siden Gerard Genettes ”Discours du récit” (1972) er distinktionen mellem hvem, der taler, og hvem, der ser, blevet cementeret som et grundparadigme i narratologien og litteraturteorien. Genettes pointe var, at den etablerede narrative teori – som fx Wayne C. Booths The Rhetoric of Fiction (1961...... narratologi blevet forsøgt udfordret, enten fordi det hævdes, at en tekst ikke nødvendigvis er udstyret med en fortæller, eller fordi begrebet om fortæller antages at bero på en misvisende og reduktiv antropomorficering. Eller omvendt fordi der i Genettes begrebsdannelse ligger en forkastelse af...... forestillingen om en implicit forfatter (implied author) og dermed også en afvisning af en upålidelige fortæller. Kapitlet præsenterer begreberne fortæller og synsvinkel i narratologien med afsæt i Genettes bestemmelser og diskutere de problemer, der opstår i kølvandet herpå. Det være sig både de rent...
Tay-Sachs disease: current perspectives from Australia
Directory of Open Access Journals (Sweden)
Lew RM
2015-01-01
Full Text Available Raelia M Lew,1,7 Leslie Burnett,2,3,4 Anné L Proos,2 Martin B Delatycki5,6 1Department of Obstetrics and Gynecology, QEII Research Institute for Mothers and Infants, The University of Sydney, Australia; 2NSW Health Pathology North, Royal North Shore Hospital, St Leonards, Australia; 3SEALS, Prince of Wales Hospital, Randwick, Australia; 4Sydney Medical School-Northern, Royal North Shore Hospital E25, University of Sydney, Sydney, Australia; 5Department of Clinical Genetics, Austin Health, Heidelberg, Australia; 6Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville, Australia; 7Department of Obstetrics and Gynaecology, Dentistry and Health Sciences, Faculty of Medicine, The University of Melbourne, Melbourne, Australia Abstract: Tay-Sachs disease (TSD is a fatal, recessively inherited neurodegenerative condition of infancy and early childhood. Although rare in most other populations, the carrier frequency is one in 25 in Ashkenazi Jews. Australian high-school-based TSD preconception genetic screening programs aim to screen, educate, and optimize reproductive choice for participants. These programs have demonstrated high uptake, low psychological morbidity, and have been shown to result in fewer than expected Jewish TSD-affected births over 18 years of operation. The majority of Jewish individuals of reproductive age outside of the high school screening program setting in Australia have not accessed screening. Recent recommendations advocate supplementing the community high school screening programs with general practitioner- and obstetrician-led genetic screening of Ashkenazi Jewish individuals for TSD and other severe recessive diseases for which this group is at risk. Massively parallel DNA sequencing is expected to become the testing modality of choice over the coming years. Keywords: Tay-Sachs disease, genetic screening, Australia
Barritt, Andrew W; Anderson, Stuart J; Leigh, P Nigel; Ridha, Basil H
2017-10-01
We discuss the assessment and differential diagnoses of a young adult Hungarian man with a 1-year history of a progressive and symmetric amyotrophic lateral sclerosis-like syndrome, along with irregular action tremor and stimulus-sensitive myoclonus of the arms. MR scan of the brain showed isolated cerebellar atrophy and formal neuropsychometric testing identified significant subclinical deficits in attention, processing speed and memory. We suspected a form of GM 2 gangliosidosis, and white cell enzyme analysis showed markedly reduced enzymatic activity of β-hexosaminidase A. Genetic testing subsequently revealed two heterozygous pathogenic mutations in the HEXA gene (c.1499delT p.(Leu500fs) and c.805G>A p.(Gly269Ser)), confirming the very rare diagnosis of adult-onset Tay-Sachs disease. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Address of U.S. President George W. Bush / George W. Bush
Bush, George W., 1946-
2005-01-01
Ilmunud ka: Eesti Päevaleht : Mõte 10. juuni lk. 9-11. Ameerika Ühendriikide presidendi George Bushi Läti visiidi ajal 7. mail peetud kõne. Ajal. Eesti Päevaleht : Möte toodud ka George W. Bushi CV. Ajal. The Baltic Times lüh.
Directory of Open Access Journals (Sweden)
Anaita Udwadia-Hegde MD, DCH, MRCPCH
2017-01-01
Full Text Available Background: Juvenile Tay-Sachs disease is rarer than other forms of Tay-Sachs disease and is usually seen in children between the age of 2 and 10 years. Pyrimethamine as a pharmacological chaperone was used to increase β-hexosaminidase A activity in this patient. Patient: We describe a patient with Tay-Sachs disease from the Indian population, a juvenile case who presented with developmental regression starting at the age of three, initially with motor followed by language regression. She is currently incapacitated with severe behavioral issues. Conclusion: This brief communication gives an insight into the efficacy of pharmacological chaperones. It also describes two unreported mutations in hexosaminidase A gene from the Indian population. After commencing Pyrimethamine, though initial benefits with increase in levels corresponded with briefly halting the motor regression, the observed increase was only transient and not associated with discernible beneficial neurological or psychiatric effects.
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Sajan D George. Articles written in Resonance – Journal of Science Education. Volume 17 Issue 7 July 2012 pp 682-690 General Article. Microfluidics – A Lab in Your Palm · Dileep Mampallil Sajan D George · More Details Fulltext PDF ...
Colaianni, Alessandra; Chandrasekharan, Subhashini; Cook-Deegan, Robert
2010-04-01
Genetic testing for Tay-Sachs and Canavan disease is particularly important for Ashkenazi Jews, because both conditions are more frequent in that population. This comparative case study was possible because of different patenting and licensing practices. The role of DNA testing differs between Tay-Sachs and Canavan diseases. The first-line screening test for Tay-Sachs remains an enzyme activity test rather than genotyping. Genotyping is used for preimplantation diagnosis and confirmatory testing. In contrast, DNA-based testing is the basis for Canavan screening and diagnosis. The HEXA gene for Tay-Sachs was cloned at the National Institutes of Health, and the gene was patented but has not been licensed. The ASPA gene for Canavan disease was cloned and patented by Miami Children's Hospital. Miami Children's Hospital did not inform family members and patient groups that had contributed to the gene discovery that it was applying for a patent, and pursued restrictive licensing practices when a patent issued in 1997. This led to intense controversy, litigation, and a sealed, nonpublic 2003 settlement that apparently allowed for nonexclusive licensing. A survey of laboratories revealed a possible price premium for ASPA testing, with per-unit costs higher than for other genetic tests in the Secretary's Advisory Committee on Genetics, Health, and Society case studies. The main conclusion from comparing genetic testing for Tay-Sachs and Canavan diseases, however, is that patenting and licensing conducted without communication with patients and advocates cause mistrust and can lead to controversy and litigation, a negative model to contrast with the positive model of patenting and licensing for genetic testing of cystic fibrosis.
Arciero, Robert A; Parrino, Anthony; Bernhardson, Andrew S; Diaz-Doran, Vilmaris; Obopilwe, Elifho; Cote, Mark P; Golijanin, Petr; Mazzocca, Augustus D; Provencher, Matthew T
2015-06-01
Bone loss in anterior glenohumeral instability occurs on both the glenoid and the humerus; however, existing biomechanical studies have evaluated glenoid and humeral head defects in isolation. Thus, little is known about the combined effect of these bony lesions in a clinically relevant model on glenohumeral stability. The purpose of this study was to determine the biomechanical efficacy of a Bankart repair in the setting of bipolar (glenoid and humeral head) bone defects determined via computer-generated 3-dimensional (3D) modeling of 142 patients with recurrent anterior shoulder instability. The null hypothesis was that adding a bipolar bone defect will have no effect on glenohumeral stability after soft tissue Bankart repair. Controlled laboratory study. A total of 142 consecutive patients with recurrent anterior instability were analyzed with 3D computed tomography scans. Two Hill-Sachs lesions were selected on the basis of volumetric size representing the 25th percentile (0.87 cm(3); small) and 50th percentile (1.47 cm(3); medium) and printed in plastic resin with a 3D printer. A total of 21 cadaveric shoulders were evaluated on a custom shoulder-testing device permitting 6 degrees of freedom, and the force required to translate the humeral head anteriorly 10 mm at a rate of 2.0 mm/s with a compressive load of 50 N was determined at 60° of glenohumeral abduction and 60° of external rotation. All Bankart lesions were made sharply from the 2- to 6-o'clock positions for a right shoulder. Subsequent Bankart repair with transosseous tunnels using high-strength suture was performed. Hill-Sachs lesions were made in the cadaver utilizing a plastic mold from the exact replica off the 3D printer. Testing was conducted in the following sequence for each specimen: (1) intact, (2) posterior capsulotomy, (3) Bankart lesion, (4) Bankart repair, (5) Bankart lesion with 2-mm glenoid defect, (6) Bankart repair, (7) Bankart lesion with 2-mm glenoid defect and Hill-Sachs lesion
Expanding the spectrum of HEXA mutations in Indian patients with Tay-Sachs disease.
Sheth, Jayesh; Mistri, Mehul; Datar, Chaitanya; Kalane, Umesh; Patil, Shekhar; Kamate, Mahesh; Shah, Harshuti; Nampoothiri, Sheela; Gupta, Sarita; Sheth, Frenny
2014-01-01
Tay-Sachs disease is an autosomal recessive neurodegenerative disorder occurring due to impaired activity of β-hexosaminidase-A (EC 3.2.1.52), resulting from the mutation in HEXA gene. Very little is known about the molecular pathology of TSD in Indian children except for a few mutations identified by us. The present study is aimed to determine additional mutations leading to Tay-Sachs disease in nine patients confirmed by the deficiency of β-hexosaminidase-A (C (D175A) and c.805G>C (p.G269R) in one case; and one small 1 bp deletion c.426delT (p.F142LfsX57) and one splice site mutation c.459+4A>C in the other two cases respectively. None of these mutations were detected in 100 chromosomes from healthy individuals of the same ethnic group. Three previously reported missense mutations, (i) c.532C>T (p.R178C), (ii) c.964G>T (p.D322Y), and (iii) c.1385A>T (p.E462V); two nonsense mutations (i) c.709C>T (p.Q237X) and (ii) c.1528C>T (p.R510X), one 4 bp insertion c.1277_1278insTATC (p.Y427IfsX5) and one splice site mutation c.459+5G>A were also identified in six cases. We observe from this study that novel mutations are more frequently observed in Indian patients with Tay-Sachs disease with clustering of ~ 73% of disease causing mutations in exons 5 to 12. This database can be used for a carrier rate screening in the larger population of the country.
Substrate reduction therapy in the infantile form of Tay-Sachs disease.
Bembi, B; Marchetti, F; Guerci, V I; Ciana, G; Addobbati, R; Grasso, D; Barone, R; Cariati, R; Fernandez-Guillen, L; Butters, T; Pittis, M G
2006-01-24
Substrate reduction therapy (SRT) with miglustat has been proposed for treatment of some lysosomal storage disorders. Based on the positive experience in Gaucher disease and experimental data in Tay-Sachs (TSD) and Sandhoff animal models, the authors investigated the clinical efficacy of SRT in two patients with infantile TSD. SRT could not arrest the patients' neurologic deterioration. However, a significant drug concentration in CSF as well as macrocephaly prevention were observed.
2013-01-01
24.7 Fort Carson 8,677 1.7 9.0 24.8 Fort Drum 5,116 2.5 12.9 25.0 Fort Eustis 3,073 2.5 11.5 25.1 Fort George Meade 1,893 2.4 14.0 25.1 101...Fort George Meade 348 4.04 7.76 24.95 Fort Gordon 1,025 3.04 7.23 25.21 Fort Hood 3,221 2.11 4.47 25.26 Fort Huachuca 558 3.61 5.94 25.04 Fort Irwin...shape public policy (Cobb and Rixford, 1998).6 In 1929, President Herbert Hoover established an ad hoc committee to examine social change in America
Miklyaeva, Elena I; Dong, Weijia; Bureau, Alexandre; Fattahie, Roya; Xu, Yongqin; Su, Meng; Fick, Gordon H; Huang, Jing-Qi; Igdoura, Suleiman; Hanai, Nobuo; Gravel, Roy A
2004-03-19
Tay-Sachs disease is an autosomal recessive neurodegenerative disease resulting from a block in the hydrolysis of GM2 ganglioside, an intermediate in ganglioside catabolism. The mouse model of Tay-Sachs disease (Hexa -/-) has been described as behaviorally indistinguishable from wild type until at least 1 year of age due to a sialidase-mediated bypass of the metabolic defect that reduces the rate of GM2 ganglioside accumulation. In this study, we have followed our mouse model to over 2 years of age and have documented a significant disease phenotype that is reminiscent of the late onset, chronic form of human Tay-Sachs disease. Onset occurs at 11-12 months of age and progresses slowly, in parallel with increasing storage of GM2 ganglioside. The disease is characterized by hind limb spasticity, weight loss, tremors, abnormal posture with lordosis, possible visual impairment, and, late in the disease, muscle weakness, clasping of the limbs, and myoclonic twitches of the head. Immunodetection of GM2 ganglioside showed that storage varies widely in different regions, but is most intense in pyriform cortex, hippocampus (CA3 field, subiculum), amygdala, hypothalamus (paraventricular supraoptic, ventromedial and arcuate nuclei, and mammilary body), and the somatosensory cortex (layer V) in 1- to 2-year-old mutant mice. We suggest that the Tay-Sachs mouse model is a phenotypically valid model of disease and may provide for a reliable indicator of the impact of therapeutic strategies, in particular geared to the late onset, chronic form of human Tay-Sachs disease.
Characterization of two Turkish beta-hexosaminidase mutations causing Tay-Sachs disease.
Ozkara, Hatice Asuman; Sandhoff, Konrad
2003-04-01
Two homoallelic mutations have recently been identified in the alpha-subunit of hexosaminidase A (EC 3.2.1.52) causing the infantile form of Tay-Sachs disease in Turkish patients. Both of these mutations, a 12 bp deletion (1096-1107 or 1098-1108 or 1099-1109) in exon 10 and a point mutation (G1362 to A, Gly454 to Asp) in exon 12, are located in the catalytic domain of the hexosaminidase alpha-chain. In order to determine whether these mutations affect the function of the catalytic domain or result in an instable protein, both mutant cDNAs were overexpressed in COS-1 cells. As judged by Western blotting, transfections of wild-type cDNA produced pro-alpha-chain and mature alpha-chain in parallel with a fivefold increase in cellular hexosaminidase activity using the synthetic substrate 4-methylumbelliferyl beta-N-acetylglucosamine 6-sulfate (MUGS). However, both mutants produced only pro-alpha-chains, although no mature form or detectable hexosaminidase activity towards two different synthetic substrates was observed. These data are consistent with the biochemical phenotype of infantile Tay-Sachs disease. We conclude that the overexpressed mutant pro-alpha-chains were misfolded and could not undergo further proteolytic processing to the active form of the enzyme in the lysosome.
Expanding the spectrum of HEXA mutations in Indian patients with Tay–Sachs disease
Directory of Open Access Journals (Sweden)
Jayesh Sheth
2014-01-01
Full Text Available Tay–Sachs disease is an autosomal recessive neurodegenerative disorder occurring due to impaired activity of β-hexosaminidase-A (EC 3.2.1.52, resulting from the mutation in HEXA gene. Very little is known about the molecular pathology of TSD in Indian children except for a few mutations identified by us. The present study is aimed to determine additional mutations leading to Tay–Sachs disease in nine patients confirmed by the deficiency of β-hexosaminidase-A (C (D175A and c.805G>C (p.G269R in one case; and one small 1 bp deletion c.426delT (p.F142LfsX57 and one splice site mutation c.459+4A>C in the other two cases respectively. None of these mutations were detected in 100 chromosomes from healthy individuals of the same ethnic group. Three previously reported missense mutations, (i c.532C>T (p.R178C, (ii c.964G>T (p.D322Y, and (iii c.1385A>T (p.E462V; two nonsense mutations (i c.709C>T (p.Q237X and (ii c.1528C>T (p.R510X, one 4 bp insertion c.1277_1278insTATC (p.Y427IfsX5 and one splice site mutation c.459+5G>A were also identified in six cases. We observe from this study that novel mutations are more frequently observed in Indian patients with Tay–Sachs disease with clustering of ~73% of disease causing mutations in exons 5 to 12. This database can be used for a carrier rate screening in the larger population of the country.
ACOG committee opinion. Number 318, October 2005. Screening for Tay-Sachs disease.
2005-10-01
Tay-Sachs disease (TSD) is a severe progressive neurologic disease that causes death in early childhood. Carrier screening, should be offered before pregnancy to individuals and couples at high-risk, including those of Ashkenazi Jewish, French-Canadian, or Cajun descent and those with a family history consistent with TSD. If both partners are determined to be carriers of TSD, genetic counseling and prenatal diagnosis should be offered.
Doença de Tay-Sachs em criança de raça negra Tay-Sachs disease in a Negro child
Directory of Open Access Journals (Sweden)
Sérgio Rosemberg
1970-12-01
Full Text Available É relatado um caso de doença de Tay-Sachs em criança da raça negra. O encontro desta entidade em indivíduos não judeus é bastante raro, sendo este o quinto caso descrito em criança negra. Os autores estudam alguns aspectos genéticos, chegando à conclusão de que o cálculo da freqüência do gene mutante é impossível devido ao pequeno número de casos e ao fato de que não há estimativas seguras quanto à taxa de nascimento de indivíduos negros na população, Em que pese o fato de o diagnóstico se assentar em bases puramente clínicas e anatômicas, prescindindo os autores de exames bioquímicos específicos, os dados apresentados são congruentes com os casos clássicos descritos na literatura.A case of Tay-Sachs diseases in a Negro child is reported. The occurrence of this disease in non-Jewish individuals is very rare and this is the fifth case of a Negro-child reported in the litterature. Some genetical aspects are studied and the authors conclude that the frequency calculation of the mutant gene is impossible due to the small number of cases and to the fact that there is reliable information regarding the rate of birth of Negro individuals in the general population. The diagnosis was based on ophtalmological and clinical data. No specific biochemical tests were performed but the data obtained are congruent with other cases reported in the litterature.
Hayase, Tomomi; Shimizu, Jun; Goto, Tamako; Nozaki, Yasuyuki; Mori, Masato; Takahashi, Naoto; Namba, Eiji; Yamagata, Takanori; Momoi, Mariko Y
2010-03-01
We report the case of a girl with Tay-Sachs disease who had convulsions and deteriorated rapidly after an upper respiratory infection at the age of 11 months. At the age of 16 months, her seizures became intractable and magnetic resonance imaging of the brain showed high signal intensity on T2-weighted images and marked swelling in the white matter and basal nucelei of the right hemisphere. Her seizures and right hemisphere lesion improved with glycerol and dexamethasone treatment. When dexamethasone was discontinued, her symptoms worsened and lesions later appeared in the left hemisphere. Her cerebrospinal fluid showed elevated levels of the cytokines TNF-alpha and IL-5. It is considered that inflammation contributes to disease progression in Tay-Sachs disease.
2004-01-01
George Hampton, who died recently, was CERN's Director of Administration in the 1960s and an important member of the team who managed the growth of CERN as it left the construction period and became a world-class physics laboratory. George came to CERN in the 1963, when the laboratory was just starting its main research activities after the intense period of construction for the Proton Synchrotron (PS). At that time the laboratory was passing through a major budget crisis, and the new Director-general, Viki Weisskopf, was faced with a completely new structure set up by his predecessor John Adams, with 12 divisions for running the laboratory reporting directly to him, and with four Directors. With the renewal of the position of Director of Administration in 1963, Weisskopf selected George Hampton from candidates from the Member States. He came from the UK Atomic Energy Authority, but had worked earlier as a delegate to the international Civil Aviation Organization. George's position at the start was to hel...
Neuro-ophthalmology of late-onset Tay-Sachs disease (LOTS).
Rucker, J C; Shapiro, B E; Han, Y H; Kumar, A N; Garbutt, S; Keller, E L; Leigh, R J
2004-11-23
Late-onset Tay-Sachs disease (LOTS) is an adult-onset, autosomal recessive, progressive variant of GM2 gangliosidosis, characterized by involvement of the cerebellum and anterior horn cells. To determine the range of visual and ocular motor abnormalities in LOTS, as a prelude to evaluating the effectiveness of novel therapies. Fourteen patients with biochemically confirmed LOTS (8 men; age range 24 to 53 years; disease duration 5 to 30 years) and 10 age-matched control subjects were studied. Snellen visual acuity, contrast sensitivity, color vision, stereopsis, and visual fields were measured, and optic fundi were photographed. Horizontal and vertical eye movements (search coil) were recorded, and saccades, pursuit, vestibulo-ocular reflex (VOR), vergence, and optokinetic (OK) responses were measured. All patients showed normal visual functions and optic fundi. The main eye movement abnormality concerned saccades, which were "multistep," consisting of a series of small saccades and larger movements that showed transient decelerations. Larger saccades ended earlier and more abruptly (greater peak deceleration) in LOTS patients than in control subjects; these changes can be attributed to premature termination of the saccadic pulse. Smooth-pursuit and slow-phase OK gains were reduced, but VOR, vergence, and gaze holding were normal. Patients with late-onset Tay-Sachs disease (LOTS) show characteristic abnormalities of saccades but normal afferent visual systems. Hypometria, transient decelerations, and premature termination of saccades suggest disruption of a "latch circuit" that normally inhibits pontine omnipause neurons, permitting burst neurons to discharge until the eye movement is completed. These measurable abnormalities of saccades provide a means to evaluate the effects of novel treatments for LOTS.
Atypical presentation of late-onset Tay-Sachs disease.
Deik, Andres; Saunders-Pullman, Rachel
2014-05-01
Late-onset Tay-Sachs disease (LOTS) is a lysosomal storage disease caused by deficient Beta-hexosaminidase A activity. We describe a 53-year-old woman who presented with adult-onset leg weakness, and whose initial diagnosis was progressive muscular atrophy without identifiable etiology. Development of cerebellar ataxia in mid-life prompted reassessment. Beta-hexosaminidase A quantification assay demonstrated absence of the isozyme. Genetic testing identified compound heterozygous mutations in the HEXA gene, confirming the diagnosis of LOTS. The phenotypic spectrum of LOTS includes motor neuronopathy, ataxia, choreoathetosis, neuropathy, and psychiatric symptoms in various combinations. This patient highlights the emergence of different clinical features over many years and emphasizes the need to consider LOTS in the differential diagnosis of progressive muscular atrophy. Copyright © 2013 Wiley Periodicals, Inc.
Generalized Bondi-Sachs equations for characteristic formalism of numerical relativity
Cao, Zhoujian; He, Xiaokai
2013-11-01
The Cauchy formalism of numerical relativity has been successfully applied to simulate various dynamical spacetimes without any symmetry assumption. But discovering how to set a mathematically consistent and physically realistic boundary condition is still an open problem for Cauchy formalism. In addition, the numerical truncation error and finite region ambiguity affect the accuracy of gravitational wave form calculation. As to the finite region ambiguity issue, the characteristic extraction method helps much. But it does not solve all of the above issues. Besides the above problems for Cauchy formalism, the computational efficiency is another problem. Although characteristic formalism of numerical relativity suffers the difficulty from caustics in the inner near zone, it has advantages in relation to all of the issues listed above. Cauchy-characteristic matching (CCM) is a possible way to take advantage of characteristic formalism regarding these issues and treat the inner caustics at the same time. CCM has difficulty treating the gauge difference between the Cauchy part and the characteristic part. We propose generalized Bondi-Sachs equations for characteristic formalism for the Cauchy-characteristic matching end. Our proposal gives out a possible same numerical evolution scheme for both the Cauchy part and the characteristic part. And our generalized Bondi-Sachs equations have one adjustable gauge freedom which can be used to relate the gauge used in the Cauchy part. Then these equations can make the Cauchy part and the characteristic part share a consistent gauge condition. So our proposal gives a possible new starting point for Cauchy-characteristic matching.
Karimzadeh, Parvaneh; Jafari, Narjes; Nejad Biglari, Habibeh; Jabbeh Dari, Sayena; Ahmad Abadi, Farzad; Alaee, Mohammad-Reza; Nemati, Hamid; Saket, Sasan; Tonekaboni, Seyed Hasan; Taghdiri, Mohammad-Mahdi; Ghofrani, Mohammad
2014-01-01
GM2-Gangliosidosis disease is a rare autosomal recessive genetic disorder that includes two disorders (Tay-Sachs and Sandhoff disease).These disorders cause a progressive deterioration of nerve cells and inherited deficiency in creating hexosaminidases A, B, and AB. Patients who were diagnosed withGM2-Gangliosidosis in the Neurology Department of Mofid Children's Hospital in Tehran, Iran from October 2009 to February 2014were included in our study. The disorder was confirmed by neurometabolic and enzyme level detection of hexosaminidases A, B, and AB in reference to Wagnester Laboratory in Germany. We assessed age, gender, past medical history, developmental status, clinical manifestations, and neuroimaging findings of 9 patients with Sandhoff disease and 9 with Tay Sachs disease. 83% of our patients were the offspring of consanguineous marriages. All of them had a developmental disorder as a chief complaint. 38%of patients had a history of developmental delay or regression and 22% had seizures. The patients with Sandhoff and Tay Sachs disease were followed for approximately 5 years and the follow-up showed all patients were bedridden or had expired due to refractory seizures, pneumonia aspiration, or swallowing disorders. Neuro-imaging findings included bilateral thalamic involvement, brain atrophy, and hypo myelination in near half of our patients (48%). According to the results of this study, we suggest that cherry-red spots, hyperacusis, refractory seizures, and relative parents in children with developmental delay and/or regression should be considered for assessment of GM2-Gangliosidosis disease.
Defense.gov Special Report: Fort Hood Shooting
identify possible insider threats, Army Secretary John M. McHugh told lawmakers. Story Obama: Soldiers ," Army Secretary John M. McHugh told lawmakers. Story President Praises Swift Response to Fort Hood Remarks on Fort Hood Shooting at White House McHugh, Odierno Address Fort Hood Shooting Before Congress
Energy Technology Data Exchange (ETDEWEB)
Proia, R.L.; Yamanaka, S.; Johnson, M.D. [and others
1994-09-01
Tay-Sachs disease, the prototype of the G{sub M2} gangliosidoses, is a catastrophic neurodegenerative disorder of infancy. The disease is caused by mutations in the HEXA gene resulting in an absence of the lysosomal enzyme, {beta}-hexosaminidase A. As consequence of the enzyme deficiency, G{sub M2} ganglioside accumulates progressively, beginning early in fetal life, to excessive amounts in the central nervous system (CNS). Rapid mental and motor deterioration starting in the first year of life leads to death by 2 to 4 years of age. Through the targeted disruption of the Hexa gene in embryonic stem cells, we have produced mice with biochemical and neuropathologic features of Tay-Sachs disease. The mutant mice exhibited less than 1% of normal {beta}-hexosaminidase A activity and accumulated G{sub M2} ganglioside in their CNS in an age-dependent manner. The accumulated ganglioside was stored in neurons as membranous cytoplasmic bodies characteristically found in the neurons of Tay-Sachs disease patients. At three to five months of age the mutant mice showed no apparent defects in motor or memory function. These {beta}-hexosaminidase A deficient mice should be useful for devising strategies to introduce functional enzymes and genes into the CNS. This model may also be valuable for studying the biochemical and pathologic changes occurring during the course of the disease.
Fuis, Gary S.; Haeussler, Peter J.; Atwater, Brian F.
2015-01-01
In a long and distinguished career, George Plafker made fundamental advances in understanding of megathrust tectonics, tsunami generation, paleoseismology, crustal neotectonics, and Alaskan geology, chiefly by means of geological field observations. George discovered that giant earthquakes result from tens of meters of seismic slip on subduction megathrusts, and he did this before the theory of plate tectonics had become a paradigm. The discovery was founded on George's comprehensive mapping of land-level changes in the aftermath of the 1964 earthquake in Alaska, and on his follow-up mapping, in 1968, in the region of the 1960 earthquakes in Chile. The mapping showed paired, parallel belts of coseismic uplift largely offshore and coseismic subsidence mostly onshore – a pattern now familiar as the initial condition assumed in simulations of subduction-zone tsunamis. George recognized, moreover, that splay faulting can play a major role in tsunami generation, and he also distinguished carefully between tectonic and landslide sources for the multiple tsunamis that accounted for nearly all the fatalities associated with the 1964 Alaska earthquake. George's classic monographs on the 1964 earthquake include findings on subduction-zone paleoseismology that he soon extended to include stratigraphic evidence for cyclic vertical deformation at the Copper River Delta, as well as recurrent uplift evidenced by flights of marine terraces at Middleton Island. As a geologist of earthquakes, George also clarified the tectonics and hazards of crustal faulting in Alaska, California, and other areas worldwide. All the while, George was mapping bedrock geology in Alaska, where he contributed importantly to today's understanding of how terranes were accreted and modified. Especially important was his documentation of the origin, movement, subduction, and collision of the Yakutat terrane in southern Alaska.
George Chester Stone (1924-2013).
Adler, Nancy
2014-01-01
George Chester Stone was born February 21, 1924, and died on July 13, 2013. A quiet revolutionary, George was a founder of the field of health psychology. George played critical roles conceptualizing the field of health psychology, charting its bounds and potential, promulgating guidelines for training, founding the first doctoral program in health psychology, editing influential volumes defining the new field, launching the flagship journal for the field, and establishing a home for the field within APA. He was able to accomplish all this through his talent for working collaboratively. 2014 APA, all rights reserved
Hawking, Lucy; Parsons, Gary
2009-01-01
George and Annie explore the galaxy in this cosmic adventure from Stephen Hawking and Lucy Hawking, complete with essays from Professor Hawking about the latest in space travel. George is heartbroken when he learns that his friend Annie and her father are moving to the US. Eric has a new job working for the space program, looking for signs of life in the Universe. Eric leaves George with a gift—a book called The User’s Guide to the Universe. But Annie and Eric haven’t been gone for very long when Annie believes that she is being contacted by aliens, who have a terrible warning for her. George joins her in the US to help her with her quest—and before he knows it, he, Annie, Cosmos, and Annie’s annoying cousin Emmett have been swept up in a cosmic treasure hunt, spanning the whole galaxy and beyond. Lucy Hawking's own experiences in zero-gravity flight and interviews with astronauts at Cape Kennedy and the Johnson Space Center lend the book a sense of realism and excitement that is sure to fire up ima...
Shock absorption of below-knee prostheses : A comparison between the SACH and the Multiflex foot
van Leeuwen, J. L.; Speth, L. A W M; Daanen, H. A M
1990-01-01
Shock waves were measured during walking on a treadmill on the metal tube of a below-knee KBM prosthesis, provided either with a SACH foot or with a Multiflex foot. Accelerations were measured in the axial direction and the dorso-ventral direction, about 160 mm proximal to the sole of the shoe. The
Kantowski-Sachs multidimensional cosmological models and dynamical dimensional reduction
International Nuclear Information System (INIS)
Demianski, M.; Rome Univ.; Golda, Z.A.; Heller, M.; Szydlowski, M.
1988-01-01
Einstein's field equations are solved for a multidimensional spacetime (KS) x Tsup(m), where (KS) is a four-dimensional Kantowski-Sachs spacetime and Tsup(m) is an m-dimensional torus. Among all possible vacuum solutions there is a large class of spacetimes in which the macroscopic space expands and the microscopic space contracts to a finite volume. We also consider a non-vacuum case and we explicitly solve the field equations for the matter satisfying the Zel'dovich equation of state. In non-vacuum models, with matter satisfying an equation of state p = γρ, O ≤ γ < 1, at a sufficiently late stage of evolution the microspace always expands and the dynamical dimensional reduction does not occur. (author)
International Nuclear Information System (INIS)
Roth, M.J.
1983-09-01
There are three distinct versions of the WIMS lattice cell program. WIMS-E is the most general, WIMSD4 is restricted to clusters or to one dimensional slab or annular geometry, and LWRWIMS is designed principally for light water reactor geometries. W-FORTE is used to transfer data from WIMSD4 or LWRWIMS to WIMS-E. A description of the W-FORTE module is given, and includes the relevant data for WIMSD4, LWRWIMS and W-FORTE. (UK)
Hawking, Lucy; Parsons, Gary
2012-01-01
George has problems. He has twin baby sisters at home who demand his parents’ attention. His beloved pig Freddy has been exiled to a farm, where he’s miserable. And worst of all, his best friend, Annie, has made a new friend whom she seems to like more than George. So George jumps at the chance to help Eric with his plans to run a big experiment in Switzerland that seeks to explore the earliest moment of the universe. But there is a conspiracy afoot, and a group of evildoers is planning to sabotage the experiment. Can George repair his friendship with Annie and piece together the clues before Eric’s experiment is destroyed forever? This engaging adventure features essays by Professor Stephen Hawking and other eminent physicists about the origins of the universe and ends with a twenty-page graphic novel that explains how the Big Bang happened—in reverse!
Energy Technology Data Exchange (ETDEWEB)
Richard, M.; Triggs-Raine, B. [Univ. of Manitoba, Winnipeg (Canada); Natowicz, M. [E.K. Shriver Center, Waltham, MA (United States)
1994-09-01
Tay-Sachs disease is an autosomal recessive lysosomal storage disorder resulting from mutations in the HEXA gene that cause a deficiency in the activity of that enzyme {beta}-hexosaminidase A (Hex A). This deficiency leads to the build-up of G{sub M2} ganglioside, resulting in neurodegeneration and death. Biochemical analysis of a non-Jewish patient with a late-infantile form of Tay-Sachs disease revealed a substantial level of Hex A activity (38.4%) when 4-MUG was used as the substrate. However, when a substrate (4-MUGS) specific for the {alpha}-subunit of Hex A ({alpha}{beta}) was used, almost no activity was detected in the HEXA gene of the patient using SSCP analysis followed by sequencing. The first mutation, a G533A substitution in exon 5, is previously described and associated with the B1 form of Tay-Sachs disease. The second mutation is a novel a-to-g base change at the +3 position of intron 8. This was confirmed using the AIRS method, whereby a MaeIII site was created in the presence of the mutation. Normal and patient mRNA was reverse transcribed and exons 7 to 9 were PCR-amplified from the cDNA. An abnormally sized amplification product detected only in the patient cDNA was sequenced; exon 8 had been deleted and exons 7 and 9 were spliced together. A substantial level of normally-sized PCR product was also detected in the patient`s cDNA. Experiments are in progress to determine if this is produced from the allele harboring the G533A mutation. Given that previous mutations of this type have been associated with 97-100% abnormal splicing, this mutation is likely to be the cause, together with the G533A mutation, of Tay-Sachs disease in this patient.
International Nuclear Information System (INIS)
Wang, Y. T.; Xu, L. X.; Gui, Y. X.
2010-01-01
In this paper, we investigate the integrated Sachs-Wolfe effect in the quintessence cold dark matter model with constant equation of state and constant speed of sound in dark energy rest frame, including dark energy perturbation and its anisotropic stress. Comparing with the ΛCDM model, we find that the integrated Sachs-Wolfe (ISW)-power spectrums are affected by different background evolutions and dark energy perturbation. As we change the speed of sound from 1 to 0 in the quintessence cold dark matter model with given state parameters, it is found that the inclusion of dark energy anisotropic stress makes the variation of magnitude of the ISW source uncertain due to the anticorrelation between the speed of sound and the ratio of dark energy density perturbation contrast to dark matter density perturbation contrast in the ISW-source term. Thus, the magnitude of the ISW-source term is governed by the competition between the alterant multiple of (1+3/2xc-circumflex s 2 ) and that of δ de /δ m with the variation of c-circumflex s 2 .
Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease.
Optican, Lance M; Rucker, Janet C; Keller, Edward L; Leigh, R John
2008-01-01
In late-onset Tay-Sachs disease (LOTS), saccades are interrupted by one or more transient decelerations. Some saccades reaccelerate and continue on before eye velocity reaches zero, even in darkness. Intervals between successive decelerations are not regularly spaced. Peak decelerations of horizontal and vertical components of oblique saccades in LOTS is more synchronous than those in control subjects. We hypothesize that these decelerations are caused by dysregulation of the fastigial nuclei (FN) of the cerebellum, which fire brain stem inhibitory burst neurons (IBNs).
Tay-Sachs disease: current perspectives from Australia.
Lew, Raelia M; Burnett, Leslie; Proos, Anné L; Delatycki, Martin B
2015-01-01
Tay-Sachs disease (TSD) is a fatal, recessively inherited neurodegenerative condition of infancy and early childhood. Although rare in most other populations, the carrier frequency is one in 25 in Ashkenazi Jews. Australian high-school-based TSD preconception genetic screening programs aim to screen, educate, and optimize reproductive choice for participants. These programs have demonstrated high uptake, low psychological morbidity, and have been shown to result in fewer than expected Jewish TSD-affected births over 18 years of operation. The majority of Jewish individuals of reproductive age outside of the high school screening program setting in Australia have not accessed screening. Recent recommendations advocate supplementing the community high school screening programs with general practitioner- and obstetrician-led genetic screening of Ashkenazi Jewish individuals for TSD and other severe recessive diseases for which this group is at risk. Massively parallel DNA sequencing is expected to become the testing modality of choice over the coming years.
Hill-Sachs lesion location: does it play a role in engagement?
Energy Technology Data Exchange (ETDEWEB)
Gyftopoulos, Soterios; Wang, Annie; Babb, James [NYU Langone Medical Center, Department of Radiology, New York, NY (United States)
2015-08-15
To see if there is an association between engagement on physical examination (PE) and the location of the Hill-Sachs lesion (HSL) as assessed by the modified biceps angle. Sixty-two patients with a history of anterior shoulder dislocation, who underwent preoperative MRI and arthroscopy at our institution and were tested for engagement on PE, were collected. Two musculoskeletal radiologists reviewed the MR studies, noting the presence of an HSL and documenting the location of the HSL with the modified biceps angle. Statistical analysis included the Mann-Whitney (MW) test and ROC (receiver-operating characteristic) curve. Of 62 patients, there were 58 males and 4 females with a mean age of 30 (range 18-59 years). Twenty patients demonstrated engagement on PE, while 42 did not. All patients had evidence of an HSL on MRI and arthroscopy. The mean biceps angle for the engaging group was 151.5 ± 13.9 , and 142.4 ± 17.3 for the non-engaging group. The biceps angle was statistically significantly higher among patients who had engagement compared to those who did not (p = 0.027). Overall, diagnostic accuracy was highest for a biceps angle >149 , which resulted in a sensitivity of 70 % and specificity of 67 %. The modified biceps angle, as measured on MRI, was significantly higher in patients who demonstrated engagement on physical examination than in those who did not. This supports the theory that the location of the Hill-Sachs lesion may play a role in engagement and may be its most important characteristic when determining its significance. (orig.)
Renewable Energy Opportunities at Fort Hood, Texas
Energy Technology Data Exchange (ETDEWEB)
Solana, Amy E.; Warwick, William M.; Orrell, Alice C.; Russo, Bryan J.; Parker, Kyle R.; Weimar, Mark R.; Horner, Jacob A.; Manning, Anathea
2011-11-14
This report presents the results of Pacific Northwest National Laboratory's (PNNL) follow-on renewable energy (RE) assessment of Fort Hood. Fort Hood receives many solicitations from renewable energy vendors who are interested in doing projects on site. Based on specific requests from Fort Hood staff so they can better understand these proposals, and the results of PNNL's 2008 RE assessment of Fort Hood, the following resources were examined in this assessment: (1) Municipal solid waste (MSW) for waste-to-energy (WTE); (2) Wind; (3) Landfill gas; (4) Solar photovoltaics (PV); and (5) Shale gas. This report also examines the regulatory issues, development options, and environmental impacts for the promising RE resources, and includes a review of the RE market in Texas.
Serial MR imaging and 1H-MR spectroscopy in monozygotic twins with Tay-Sachs disease.
Imamura, A; Miyajima, H; Ito, R; Orii, K O
2008-10-01
Four-year-old monozygotic female twins with early onset Tay-Sachs disease are described. The sisters showed similar slowly progressive clinical symptoms and deterioration, however the younger sister also demonstrated intractable myoclonus in the right leg. The serial MR images and (1)H-MR spectroscopy of the brain were obtained in both twins. MR images showed high intensity on T (2)-weighted image in the bilateral white matter, however there were no signal changes in the basal ganglia and thalamus during any of the phases. The ratio of N-acetylaspartate (NAA)/creatine (Cr) was decreased in the both white matter lesions and the corpus striatum, and that of myoinositol (mI)/Cr was increased in the damaged white matter on MR spectroscopy. The elevation of the lactate peak was clearly demonstrated in the left basal ganglia of the younger sister; however it was not shown in cerebral lesions of the elder sister. Changes in metabolites on MR spectroscopy were closely linked to the respective clinical features of each twin. Follow-up examination by (1)H-MR spectroscopy is useful for the evaluation of neuronal changes in children with Tay-Sachs disease.
More than 40 years ago, Georges Charpak invented the multi-wire proportional chamber, which revolutionized the detection of particles and which found applications in medicine. He was awarded the Nobel Prize in physics for this invention in 1992. On March 9, there will be a conference here at CERN to celebrate Georges Charpak’s 85th birthday and to pay tribute to his groundbreaking work. After an introduction by Rolf Heuer, CERN Director-General, Georges Charpak will give a short speech by videoconference. This will be followed by a talk on the invention of the multi-wire proportional chamber by Ioanis Giomataris of CEA-Saclay. You are invited to attend this special conference in the Main Auditorium, from 4.00 pm to 6.00 pm: http://indico.cern.ch/conferenceDisplay.py?confId=53188
[Dr Mavro Sachs (1817-1888): the first lecturer of Zagreb University].
Dugacki, Vladimir
2010-01-01
Mavro Sachs (Jánosháza, Hungary, 1817 % emdash; Rijeka, 1888.) was a Zagreb student since 1828. In 1846 he graduated in medicine from the University of Vienna and returned to Zagreb to be the city physician. In 1849, he started to teach forensic medicine at the School of Law of the Royal Academy of Sciences in Zagreb and continued teaching the same subject at the Zagreb University Faculty of Law in the capacity of docent (corresponds to lecturer in the British system). He also taught medical law at pharmaceutical studies of Zagreb University. From 1855 to 1860, he presided over the Jewish Community of Zagreb.
FOUR YEARS OF OPERATIONS AND RESULTS WITH FORTE
International Nuclear Information System (INIS)
D. ROUSSEL-DUPRE; P. KLINGNER; L. CARLSON; ET AL
2001-01-01
The FORTE (Fast Onboard Recording of Transient Events) satellite was launched on 29 August 1997 and has been in continuous operation since that time. FORTE was placed in a nearly circular, 825-km-altitude, 70 degrees inclination orbit by a Pegasus rocket funded by Air Force Space Test Program. The Department of Energy funded the FORTE satellite, which was designed and built at Los Alamos. FORTE's successful launch and engineered robustness were a result of several years of dedicated work by the joint Los Alamos National Laboratory/Sandia National Laboratory project team, led through mission definition, payload and satellite development, and launch by Dr. Stephen Knox. The project is now led by Dr. Abram Jacobson. FORTE carries a suite of instruments, an optical system and a rf system, for the study of lightning and anthropogenic signals. As a result of this effort, new understandings of lightning events have emerged as well as a more complete understanding of the relationship between optical and rf lightning events. This paper will provide an overview of the FORTE satellite and will discuss the on orbit performance of the subsystems
National Research Council Canada - National Science Library
Edwards, D
1989-01-01
Work assignments under this contract will include a Preliminary Assessment/Site Investigation at the former Gaithersburg NIKE Control and Launch Areas and a Remedial Investigation at the Fort Meade...
Gason, Alexandra A; Aitken, MaryAnne; Delatycki, Martin B; Sheffield, Edith; Metcalfe, Sylvia A
2004-01-01
Tay Sachs disease is a recessively inherited neurodegenerative disorder, for which carrier screening programs exist worldwide. Education for those offered a screening test is essential in facilitating informed decision-making. In Melbourne, Australia, we have designed, developed, and evaluated a computer-based instructional resource for use in the Tay Sachs disease carrier screening program for secondary school students attending Jewish schools. The resource entitled "Genetics in the Community: Tay Sachs disease" was designed on a platform of educational learning theory. The development of the resource included formative evaluation using qualitative data analysis supported by descriptive quantitative data. The final resource was evaluated within the screening program and compared with the standard oral presentation using a questionnaire. Knowledge outcomes were measured both before and after either of the educational formats. Data from the formative evaluation were used to refine the content and functionality of the final resource. The questionnaire evaluation of 302 students over two years showed the multimedia resource to be equally effective as an oral educational presentation in facilitating participants' knowledge construction. The resource offers a large number of potential benefits, which are not limited to the Tay Sachs disease carrier screening program setting, such as delivery of a consistent educational message, short delivery time, and minimum financial and resource commitment. This article outlines the value of considering educational theory and describes the process of multimedia development providing a framework that may be of value when designing genetics multimedia resources in general.
Regional neuro axonal injury detected by 1H 3 Tesla spectroscopic imaging in late onset Tay sachs
International Nuclear Information System (INIS)
Gagoski, Borjan Aleksandar; Eichler, Florian S.
2010-01-01
Late-onset Tay Sachs (LOTS) is a rare lysosomal storage disorder resulting from mutations of the subunit of the lysosomal enzyme β-hexosaminidase A, which catalyzes the degradation of GM2 ganglioside. We have applied the fast encoding spectroscopic imaging technique to LOTS patients to further investigate the neuro degenerative consequences of this disease.(Author)
Kantowski-Sachs Einstein-æther perfect fluid models
Energy Technology Data Exchange (ETDEWEB)
Latta, Joey [Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia, B3H 3J5 (Canada); Leon, Genly [Instituto de Física, Pontificia Universidad de Católica de Valparaíso, Casilla 4950, Valparaíso (Chile); Paliathanasis, Andronikos, E-mail: lattaj@mathstat.dal.ca, E-mail: genly.leon@pucv.cl, E-mail: anpaliat@phys.uoa.gr [Instituto de Ciencias Físicas y Matemáticas, Universidad Austral de Chile, Valdivia (Chile)
2016-11-01
We investigate Kantowski-Sachs models in Einstein-æ ther theory with a perfect fluid source using the singularity analysis to prove the integrability of the field equations and dynamical system tools to study the evolution. We find an inflationary source at early times, and an inflationary sink at late times, for a wide region in the parameter space. The results by A.A. Coley, G. Leon, P. Sandin and J. Latta ( JCAP 12 (2015) 010), are then re-obtained as particular cases. Additionally, we select other values for the non-GR parameters which are consistent with current constraints, getting a very rich phenomenology. In particular, we find solutions with infinite shear, zero curvature, and infinite matter energy density in comparison with the Hubble scalar. We also have stiff-like future attractors, anisotropic late-time attractors, or both, in some special cases. Such results are developed analytically, and then verified by numerics. Finally, the physical interpretation of the new critical points is discussed.
George Washington: A Grounded Leader
2011-04-08
placed in this book two years after the death of his father likely indicating he was now beginning to take possession of key documents that he...these truths would become part of the strong foundation upon which George would continue to build after the death ofhis father. As George moved into...men and women admired. He was both an I impressive horseman at a time when these talents truly counted, and became an extraordinarily graceful
George Soros : sõda terroriga on kohutav viga / George Soros ; interv. Külli-Riin Tigasson
Soros, George, 1930-
2006-01-01
Ilmunud ka: Infopress 15. dets. nr. 50 lk. 149. Miljardär ja filantroop George Soros vastab küsimustele, mis puudutavad tema raamatus "Ekslikkuse ajastu. Sõda terroriga ja selle tagajärjed" esitatud seisukohti. Ta leiab, et sõjakuulutamine terrorismile oli vale reaktsioon 11. septembri rünnakutele. George W. Bushi kursi muutumine Iraagiga seoses on tulnud liiga hilja. USA peab naasma oma traditsioonilise rolli juurde maailmas ja tegelema inimkonna suurimate probleemidega
Hawking, Lucy; Parsons, Gary
2011-01-01
Georges et Annie, sa meilleure amie, sont sur le point d'assister à l'une des plus importantes expériences scientifiques de tous les temps : explorer les premiers instants de l'Univers, le Big Bang ! Grâce à Cosmos, leur super ordinateur, et au Grand Collisionneur de hadrons créé par Éric, le père d'Annie, ils vont enfin pouvoir répondre à cette question essentielle : pourquoi existons nous ? Mais Georges et Annie découvrent qu'un complot diabolique se trame. Pire, c'est toute la recherche scientifique qui est en péril ! Entraîné dans d'incroyables aventures, Georges ira jusqu'aux confins de la galaxie pour sauver ses amis...Une plongée passionnante au coeur du Big Bang. Les toutes dernières théories de Stephen Hawking et des plus grands scientifiques actuels.
2009-01-01
CERN pays tribute to the work of Georges Charpak at a colloquium in honour of his 85th birthday. var flash_video_player=get_video_player_path(); insert_player_for_external('Video/Public/Movies/2009/CERN-MOVIE-2009-008/CERN-MOVIE-2009-008-0753-kbps-480x360-25-fps-audio-64-kbps-44-kHz-stereo', 'mms://mediastream.cern.ch/MediaArchive/Video/Public/Movies/2009/CERN-MOVIE-2009-008/CERN-MOVIE-2009-008-Multirate-200-to-753-kbps-480x360.wmv', 'false', 480, 360, 'https://mediastream.cern.ch/MediaArchive/Video/Public/Movies/2009/CERN-MOVIE-2009-008/CERN-MOVIE-2009-008-posterframe-480x360-at-10-percent.jpg', '1167500', true, 'Video/Public/Movies/2009/CERN-MOVIE-2009-008/CERN-MOVIE-2009-008-0600-kbps-maxH-360-25-fps-audio-128-kbps-48-kHz-stereo.mp4'); Watch the video conference of Georges Charpak. On 9 March CERN’s Main Auditorium was the venue for a fascinating and moving celebration marking the 85th birthday of Georges Charpak, who was awarded the Nobel Prize for Physics in 1992 for his inven...
Tay-Sachs disease: progression of changes on neuroimaging in four cases
International Nuclear Information System (INIS)
Fukumizu, M.; Yoshikawa, H.; Kurokawa, T.; Takashima, S.; Sakuragawa, N.
1992-01-01
The neuroradiological findings in four patients with Tay-Sachs disease are described in three phases of the clinical course. The basal ganglia and cerebral white matter show low density on computed tomography and high signal intensity on T2-weighted magnetic resonance imaging in the initial phase. The caudate nuclei are characteristically enlarged and protrude into the lateral ventricles in the first and second phases. The cerebral white matter shows low density on the CT which varies in extent from the second to third phases, and the whole brain becomes atrophic in the last phase. Thus, central nervous system involvement in the disease may begin in basal ganglia as well as in cerebral white matter. (orig.)
Tay-Sachs disease: progression of changes on neuroimaging in four cases
Energy Technology Data Exchange (ETDEWEB)
Fukumizu, M; Yoshikawa, H; Kurokawa, T [National Center Hospital for Mental, Nervous, and Muscular Disorders, Tokyo (Japan). Div. of Child Neurology; Takashima, S [National Inst. of Neuroscience, National Center of Neurology and Psychiatry, Tokyo (Japan). Div. of Mental Retardation and Birth Defect Research; Sakuragawa, N [National Inst. of Neuroscience, National Center of Neurology and Psychiatry, Tokyo (Japan). Div. of Inherited Metabolic Disease
1992-11-01
The neuroradiological findings in four patients with Tay-Sachs disease are described in three phases of the clinical course. The basal ganglia and cerebral white matter show low density on computed tomography and high signal intensity on T2-weighted magnetic resonance imaging in the initial phase. The caudate nuclei are characteristically enlarged and protrude into the lateral ventricles in the first and second phases. The cerebral white matter shows low density on the CT which varies in extent from the second to third phases, and the whole brain becomes atrophic in the last phase. Thus, central nervous system involvement in the disease may begin in basal ganglia as well as in cerebral white matter. (orig.).
Georges Charpak street sign unveiled
Paola Catapano
2011-01-01
While it might not be the only French street named in honour of the late Georges Charpak, who passed away in September 2010 at the age of 87, the street chosen by the mayor of Saint-Genis-Pouilly is certainly the only one located directly opposite the CERN "campus". The road overlooks buildings on the CERN Meyrin site, where Georges Charpak spent most of his career as a physicist, conducting the research that won him the Nobel Prize in Physics in 1992. From left to right: Sigurd Lettow, Dominique Charpak and the mayor of Saint-Genis-Pouilly. The unveiling took place on 17 October and was organised by the mayor of Saint-Genis-Pouilly. George Charpak’s wife, Dominique, and Sigurd Lettow, CERN Director of Administration and General Infrastructure, attended what was an intimate and touching ceremony. The mayor’s speech at the event praised Georges’ commitment to scientific education. The highlight of the event, however, was a witty and humorous ...
International Nuclear Information System (INIS)
Accioly, A.J.
1985-01-01
Exact solutions of the Einstein-Conformally Invariant Scalar Field Equations are obtained for Kantowski-Sachs and Bianchi types I and III cosmologies. The presence of the conformally invariant scalar field is responsible for some interesting features of the solutions. In particular it is found that the Bianchi I model is consistent with the big-bang theory of cosmology. (Author) [pt
Georges Charpak, Nobel Physics Prize 1992
Energy Technology Data Exchange (ETDEWEB)
Anon.
1992-12-15
Wednesday 14 October looked like being a day like any other for detector specialist Georges Charpak. Except he had an unwelcome appointment with the dentist early that afternoon. Late that morning he was able to telephone to cancel the appointment. 'I have a small problem...', he explained. The problem was the announcement that Georges Charpak receives 1992's most prestigious award for physics.
Bent's Old Fort: Amphibians and Reptiles
Muths, E.
2008-01-01
Bent's Old Fort National Historic Site sits along the Arkansas River in the semi-desert prairie of southeastern Colorado. The USGS provided assistance in designing surveys to assess the variety of herpetofauna (amphibians and reptiles) resident at this site. This brochure is the results of those efforts and provides visitors with information on what frogs, toads, snakes and salamanders might be seen and heard at Bent's Old Fort.
George A. Olah, Carbocation and Hydrocarbon Chemistry
dropdown arrow Site Map A-Z Index Menu Synopsis George A. Olah, Carbocation and Hydrocarbon Chemistry George Olah received the 1994 Nobel Prize in Chemistry "for his contribution to carbocation chemistry" and his 'role in the chemistry of hydrocarbons. In particular, he developed superacids
Georges Charpak, Nobel Physics Prize 1992
International Nuclear Information System (INIS)
Anon.
1992-01-01
Wednesday 14 October looked like being a day like any other for detector specialist Georges Charpak. Except he had an unwelcome appointment with the dentist early that afternoon. Late that morning he was able to telephone to cancel the appointment. 'I have a small problem...', he explained. The problem was the announcement that Georges Charpak receives 1992's most prestigious award for physics
Georges Charpak and his multiwire chamber
1970-01-01
In 1968, Georges Charpak developed the 'multiwire proportional chamber', a gas-filled box with a large number of parallel detector wires, each connected to individual amplifiers. Linked to a computer, it could achieve a counting rate a thousand times better than existing techniques - without a camera in sight. From left to right, Georges Charpak, Fabio Sauli and Jean-Claude Santiard working on a multiwire chamber in 1970.
Neudorfer, Orit; Pastores, Gregory M; Zeng, Bai J; Gianutsos, John; Zaroff, Charles M; Kolodny, Edwin H
2005-02-01
The purpose of this study was to describe the phenotype (and corresponding genotype) of adult patients with late-onset Tay-Sachs disease, a clinical variant of the GM2-gangliosidoses. A comprehensive physical examination, including neurological assessments, was performed to establish the current disease pattern and severity. In addition, the patients' past medical histories were reviewed. The patients' alpha-subunit mutations (beta-Hexosaminidase A genotype) were determined and correlated with their corresponding clinical findings and disease course. Twenty-one patients (current mean age: 27.0 years; range: 14-47 years) were identified. The pedigree revealed a relative with the "classic" infantile or late-onset form of Tay-Sachs disease in four (out of 18) unrelated families. The patients were predominantly male (15/21 individuals) and of Ashkenazi Jewish ancestry (15/18 families). Mean age at onset was 18.1 years; balance problems and difficulty climbing stairs were the most frequent presenting complaints. In several cases, the diagnosis was delayed (mean age at diagnosis: 27.0 years). Analysis of the beta-hex A gene revealed the G269S mutation as the most common disease allele; found in homozygosity (N = 1) or heterozygosity (N = 18; including 2 sib pairs). Disease onset (age 36 years) was delayed and progression relatively slower in the homozygous G269S patient. Two siblings (ages 28 and 31 years), of non-Jewish ancestry, were compound heterozygotes (TATC1278/W474C); their clinical course is dominated by psychiatric problems. Brain imaging studies revealed marked cerebellar atrophy in all patients (N = 18) tested, regardless of disease stage. Late-onset Tay-Sachs disease is an infrequent disorder and the diagnosis is often missed or delayed (by approximately 8 years). Early on, the majority of patients develop signs of either cerebellar or anterior motor neuron involvement. Affected individuals may also develop psychotic episodes. In most cases, the later
George and the unbreakable code
Hawking, Lucy; Parsons, Gary
2014-01-01
George and his best friend Annie haven't had any space adventures for a while and they're missing the excitement. But not for long . . . Seriously strange things start happening. Banks are handing out free money; supermarkets can't charge for their produce so people are getting free food; and aircraft are refusing to fly. It looks like the world's biggest and best computers have all been hacked. George and Annie will travel further into space than ever before in order to find out who is behind it.
Stepien, Karolina M; Lum, Su Han; Wraith, J Edmond; Hendriksz, Christian J; Church, Heather J; Priestman, David; Platt, Frances M; Jones, Simon; Jovanovic, Ana; Wynn, Robert
2017-12-07
Tay-Sachs disease is a rare metabolic disease caused by a deficiency of hexosaminidase A that leads to accumulation of GM2 gangliosides predominantly in neural tissue. Late-onset Tay-Sachs disease variant is associated with a higher level of residual HexA activity. Treatment options are limited, and there are a few described cases who have undergone haematopoietic stem cell transplantation (HSCT) with variable outcome.We describe a case of a 23-year-old male patient who presented with a long-standing tremor since 7 years of age. He had gait ataxia, a speech stammer and swallowing problems. His condition had had a static course apart from his tremor that had been gradually deteriorating. Because of the deterioration in his neurological function, the patient had an uneventful, matched-sibling donor bone marrow transplant at the age of 15 years. Eight years post-HSCT, at the age of 23, he retains full donor engraftment, and his white cell beta-HexA of 191 nmol/mg/h is comparable to normal controls (in-assay control = 187). He continues to experience some intentional tremor that is tolerable for daily life and nonprogressive since HSCT. HSCT is a potential treatment option which might arrest neurodegeneration in patients with LOTS.
Fort Collins Science Center fiscal year 2010 science accomplishments
Wilson, Juliette T.
2011-01-01
The scientists and technical professionals at the U.S. Geological Survey (USGS), Fort Collins Science Center (FORT), apply their diverse ecological, socioeconomic, and technological expertise to investigate complicated ecological problems confronting managers of the Nation's biological resources. FORT works closely with U.S. Department of the Interior (DOI) agency scientists, the academic community, other USGS science centers, and many other partners to provide critical information needed to help answer complex natural-resource management questions. In Fiscal Year 2010 (FY10), FORT's scientific and technical professionals conducted ongoing, expanded, and new research vital to the science needs and management goals of DOI, other Federal and State agencies, and nongovernmental organizations in the areas of aquatic systems and fisheries, climate change, data and information integration and management, invasive species, science support, security and technology, status and trends of biological resources (including the socioeconomic aspects), terrestrial and freshwater ecosystems, and wildlife resources, including threatened and endangered species. This report presents selected FORT science accomplishments for FY10 by the specific USGS mission area or science program with which each task is most closely associated, though there is considerable overlap. The report also includes all FORT publications and other products published in FY10, as well as staff accomplishments, appointments, committee assignments, and invited presentations.
Submission to the Georges Bank Review Panel
Energy Technology Data Exchange (ETDEWEB)
Rankin, E.; Butler, M.; Church, T.
1999-01-01
The Georges Bank, off southwestern Nova Scotia, is one of the most biologically productive continental shelf ecosystems in the world. It supports a wide diversity of species, including many seabirds. In 1988, federal and provincial legislation placed a moratorium on petroleum exploration and drilling on the Georges Bank, directing the ministers of Natural Resources Canada, and of the Nova Scotia Department of Natural Resources to make a decision regarding the moratorium by January 1, 2000. This report by the Ecology Action Centre (EAC) asks the Georges Bank Review Panel to recommend extending the moratorium on Georges Bank and adjacent areas until 2012, in part to match the American moratorium. Other reasons why the panel made this recommendation were explored. The principal reason is the EAC concern that when the moratorium is lifted, several oil and gas developments will proceed in this ecologically significant offshore area that could result in the loss of the ecological integrity of Georges Bank. The EAC contends that before oil and gas development in the region could begin, the following issues would have to be resolved: (1) disposal of drill muds and cuttings, (2) volume and disposal of produced water, (3) effects of small and large spills, (4) impact of seismic activities on whales and turtles, and (5) carbon dioxide emission through venting and flaring. Also, the EAC does not believe that developing Georges Bank will create as many jobs in the affected communities as some people suggest. Lifting the moratorium by Canada would also frustrate American environmental goals, as well as compromise Canada`s position in international environmental partnerships such as the Gulf of Maine Council. 19 refs., tabs., figs.
Submission to the Georges Bank Review Panel
International Nuclear Information System (INIS)
Rankin, E.; Butler, M.; Church, T.
1999-01-01
The Georges Bank, off southwestern Nova Scotia, is one of the most biologically productive continental shelf ecosystems in the world. It supports a wide diversity of species, including many seabirds. In 1988, federal and provincial legislation placed a moratorium on petroleum exploration and drilling on the Georges Bank, directing the ministers of Natural Resources Canada, and of the Nova Scotia Department of Natural Resources to make a decision regarding the moratorium by January 1, 2000. This report by the Ecology Action Centre (EAC) asks the Georges Bank Review Panel to recommend extending the moratorium on Georges Bank and adjacent areas until 2012, in part to match the American moratorium. Other reasons why the panel made this recommendation were explored. The principal reason is the EAC concern that when the moratorium is lifted, several oil and gas developments will proceed in this ecologically significant offshore area that could result in the loss of the ecological integrity of Georges Bank. The EAC contends that before oil and gas development in the region could begin, the following issues would have to be resolved: (1) disposal of drill muds and cuttings, (2) volume and disposal of produced water, (3) effects of small and large spills, (4) impact of seismic activities on whales and turtles, and (5) carbon dioxide emission through venting and flaring. Also, the EAC does not believe that developing Georges Bank will create as many jobs in the affected communities as some people suggest. Lifting the moratorium by Canada would also frustrate American environmental goals, as well as compromise Canada's position in international environmental partnerships such as the Gulf of Maine Council. 19 refs., tabs., figs
NSU Art Museum Fort Lauderdale | Art Museum in Fort Lauderdale
NSU Art Museum Fort Lauderdale Visit Admissions Hours & Admission Policies & Accessibility Airports Shop & Dine About the Café & Store Store Café Menu Art Exhibitions Currently on View Thursday 2-for-1 specials on wine and craft beer in the Museum Café, and hands-on art projects for all
FORTE spacecraft vibration mitigation. Final report
International Nuclear Information System (INIS)
Maly, J.R.
1996-02-01
This report documents work that was performed by CSA Engineering, Inc., for Los Alamos National Laboratory (LANL), to reduce vibrations of the FORTE spacecraft by retrofitting damped structural components into the spacecraft structure. The technical objective of the work was reduction of response at the location of payload components when the structure is subjected to the dynamic loading associated with launch and proto-qualification testing. FORTE is a small satellite that will be placed in orbit in 1996. The structure weighs approximately 425 lb, and is roughly 80 inches high and 40 inches in diameter. It was developed and built by LANL in conjunction with Sandia National Laboratories Albuquerque for the United States Department of Energy. The FORTE primary structure was fabricated primarily with graphite epoxy, using aluminum honeycomb core material for equipment decks and solar panel substrates. Equipment decks were bonded and bolted through aluminum mounting blocks to adjoining structure
Fortælling og fortolkning i Jyske Bank
DEFF Research Database (Denmark)
Albrechtsen, Charlotte
Afhandlingen præsenterer en undersøgelse af et konkret eksempel på storytelling brugt som strategisk ledelses- og kommunikationsredskab i en organisations interne kommunikation. Eksemplet er fortællingen "Slaget ved Vejle", som stammer fra Jyske Bank og udgør under afhandlingens case. De overordn......Afhandlingen præsenterer en undersøgelse af et konkret eksempel på storytelling brugt som strategisk ledelses- og kommunikationsredskab i en organisations interne kommunikation. Eksemplet er fortællingen "Slaget ved Vejle", som stammer fra Jyske Bank og udgør under afhandlingens case. De......, at medarbejderne forholder sig reflekteret, nuanceret og kritisk til den strategiske fortælling, og at der er stor diversitet i deres oplevelser, fortolkninger og vurderinger af fortællingen. Desuden ser afhandlingen nærmere på hvad begrebet "storytelling" dækker over, og hvordan der hidtil er forsket i...
Directory of Open Access Journals (Sweden)
Dominique Iogna-Prat
2006-09-01
Full Text Available Dix ans après le décès du grand maître des études médiévales, le temps est sans nul doute venu de revisiter l’œuvre de Georges Duby et d’en discuter l’actualité du point de vue de l’histoire sociale du Moyen Âge. À une seule exception – Claudie Amado, qui fut son assistante –, les historiens invités n’ont pas travaillé au contact direct de Georges Duby ; il leur a été demandé de faire, chacun dans leur domaine, le bilan des apports du maître et de mettre en perspective ses principales thèses ...
Cancer incidence in Fort Chipewyan, Alberta : 1995-2006
Energy Technology Data Exchange (ETDEWEB)
Chen, Y. [Alberta Cancer Board, Edmonton, AB (Canada). Division of Population Health and Information Surveillance
2009-02-15
A high number of cases of cholangiocarcinoma, a rare form of bile duct cancer, as well as high rates of other cancers were reported by a physician working in Fort Chipewyan, Alberta in 2006. Concerns were raised by local residents, attributing cancers in their community to environmental contamination from a range of industrial development including the oil sands development, uranium mining and pulp mills. However, an initial review of the Alberta Cancer Registry did not confirm an increased incidence of cancer in Fort Chipewyan. In the summer/fall of 2007, a working group was formed to support the Alberta Cancer Board in doing a cluster investigation based on the guidelines of the United States Centre for Disease Control and Prevention. This report presented an investigation to determine if there was an elevated rate of cholangiocarcinoma in Fort Chipewyan and whether there was an elevated rate of cancers overall in Fort Chipewyan. The report provided background information on the Athabasca oil sands, uranium mining, and Fort Chipewyan as well as previous investigations of cancer incidence in Fort Chipewyan. Study methods were also presented with particular reference to study and comparison populations; cancer classification and inclusion criteria; active case ascertainment and verification; methods of analysis; and ethical approval. Results were also presented. The specific cancers that were discussed were cholangiocarcinoma, leukemia, colon cancer, and cancer in First Nations in Alberta. It was concluded that the observed number of cases of cholangiocarcinoma was within the expected range. 121 refs., 12 tabs., 3 figs., 5 appendices.
The philosophy of Hans-Georg Gadamer / Wolfgang Drechsler
Drechsler, Wolfgang, 1963-
1998-01-01
Rets.rmt.: The philosophy of Hans-Georg Gadamer : a review of the philosophy of Hans-Georg Gadamer / Lewis Edwin Hahn, ed. Chicago and La Salle, IL: Open Court, 1997. (The Library of Living Philosophers, vol. XXIV)
Fort Collins Science Center-Fiscal year 2009 science accomplishments
Wilson, Juliette T.
2010-01-01
Public land and natural resource managers in the United States are confronted with increasingly complex decisions that have important ramifications for both ecological and human systems. The scientists and technical professionals at the U.S. Geological Survey Fort Collins Science Center?many of whom are at the forefront of their fields?possess a unique blend of ecological, socioeconomic, and technological expertise. Because of this diverse talent, Fort Collins Science Center staff are able to apply a systems approach to investigating complicated ecological problems in a way that helps answer critical management questions. In addition, the Fort Collins Science Center has a long record of working closely with the academic community through cooperative agreements and other collaborations. The Fort Collins Science Center is deeply engaged with other U.S. Geological Survey science centers and partners throughout the Department of the Interior. As a regular practice, we incorporate the expertise of these partners in providing a full complement of ?the right people? to effectively tackle the multifaceted research problems of today's resource-management world. In Fiscal Year 2009, the Fort Collins Science Center's scientific and technical professionals continued research vital to Department of the Interior's science and management needs. Fort Collins Science Center work also supported the science needs of other Federal and State agencies as well as non-government organizations. Specifically, Fort Collins Science Center research and technical assistance focused on client and partner needs and goals in the areas of biological information management and delivery, enterprise information, fisheries and aquatic systems, invasive species, status and trends of biological resources (including human dimensions), terrestrial ecosystems, and wildlife resources. In the process, Fort Collins Science Center science addressed natural-science information needs identified in the U
On the structure and applications of the Bondi-Metzner-Sachs group
Alessio, Francesco; Esposito, Giampiero
This work is a pedagogical review dedicated to a modern description of the Bondi-Metzner-Sachs (BMS) group. Minkowski space-time has an interesting and useful group of isometries, but, for a generic space-time, the isometry group is simply the identity and hence provides no significant informations. Yet symmetry groups have important role to play in physics; in particular, the Poincaré group describing the isometries of Minkowski space-time plays a role in the standard definitions of energy-momentum and angular-momentum. For this reason alone it would seem to be important to look for a generalization of the concept of isometry group that can apply in a useful way to suitable curved space-times. The curved space-times that will be taken into account are the ones that suitably approach, at infinity, Minkowski space-time. In particular we will focus on asymptotically flat space-times. In this work, the concept of asymptotic symmetry group of those space-times will be studied. In the first two sections we derive the asymptotic group following the classical approach which was basically developed by Bondi, van den Burg, Metzner and Sachs. This is essentially the group of transformations between coordinate systems of a certain type in asymptotically flat space-times. In the third section the conformal method and the notion of “asymptotic simplicity” are introduced, following mainly the works of Penrose. This section prepares us for another derivation of the BMS group which will involve the conformal structure, and is thus more geometrical and fundamental. In the subsequent sections we discuss the properties of the BMS group, e.g. its algebra and the possibility to obtain as its subgroup the Poincaré group, as we may expect. The paper ends with a review of the BMS invariance properties of classical gravitational scattering discovered by Strominger, that are finding application to black hole physics and quantum gravity in the literature.
Undervisning mellem fortælling og feedback
DEFF Research Database (Denmark)
Andersen, Kirsten Margrethe
2016-01-01
Feedback gør det muligt for den enkelte at forstå, hvordan jeg kan blive bedre til det, jeg er ved at lære. Fortællinger gør det muligt for den enkelte at udvide horisonten og derved komme til en forståelse af, hvilke mulige perspektiver der er for at forholde sig til den verden, som fortællingen...
Aktjorõ filma "Georg" vpervõje sobralis vmestje
2006-01-01
Vene näitlejanna Anastasia Makejeva ja eesti laulev näitleja Marko Matvere, kes mängivad Peeter Simmi töös olevas mängufilmis "Georg" Georg Otsa ja tema teist abikaasat Asta Otsa, alustavad homme filmivõtteid
Gilbert ja George lasevad oma kunstiteose alla laadida
2007-01-01
9.05.2007 öösel on kõigil soovijail võimalik tasuta interneti vahendusel omandada Londonis tegutseva kunstnikepaari Gilbert & George (Gilbert Proesch ja George Passmore) teos "Planed". Aadressid: www.bbc.co.uk/imagine ja www.guardian.co.uk/art
Georges Bank: a leaky incubator of Alexandrium fundyense blooms.
McGillicuddy, D J; Townsend, D W; Keafer, B A; Thomas, M A; Anderson, D M
2014-05-01
A series of oceanographic surveys on Georges Bank document variability of populations of the toxic dinoflagellate Alexandrium fundyense on time scales ranging from synoptic to seasonal to interannual. Blooms of A. fundyense on Georges Bank can reach concentrations on the order of 10 4 cells l -1 , and are generally bank-wide in extent. Georges Bank populations of A. fundyense appear to be quasi-independent of those in the adjacent coastal Gulf of Maine, insofar as they occupy a hydrographic niche that is colder and saltier than their coastal counterparts. In contrast to coastal populations that rely on abundant resting cysts for bloom initiation, very few cysts are present in the sediments on Georges Bank. Bloom dynamics must therefore be largely controlled by the balance between growth and mortality processes, which are at present largely unknown for this population. Based on correlations between cell abundance and nutrient distributions, ammonium appears to be an important source of nitrogen for A. fundyense blooms on Georges Bank.
George's secret key to the universe
Hawking, Lucy; Galfard, Christophe; Parsons, Gary
2007-01-01
In their bestselling book for young readers, noted physicist Stephen Hawking and his daughter, Lucy, provide a grand and funny adventure that explains fascinating information about our universe, including Dr. Hawking's latest ideas about black holes. It's the story of George, who's taken through the vastness of space by a scientist, his daughter, and their super-computer named Cosmos. George's Secret Key to the Universe was a New York Times bestseller and a selection of Al's Book Club on the Today show.
Georges Besse 2. A new era for enrichment
International Nuclear Information System (INIS)
2009-01-01
Since 1978, AREVA group subsidiary EURODIF's Georges Besse plant has been using gaseous diffusion to enrich uranium and meet the requirements of electricity utilities. Georges Besse II plant, which will use far less electricity, will replace George Besse not so long. The Georges Besse II plant is located on the Tricastin nuclear site in southern France. AREVA ensure delivery of uranium enrichment services in accordance with customer expectations. AREVA obtained the right to use URENCO's centrifugation technology on July 3, 2006. This is the process to be used at Georges Besse II. The new uranium enrichment plant will comprise two enrichment units, with a total production capacity of 7.5 million separative work units, which can be extended to 11 million if needed. Each enrichment unit will include: a Centrifuge Assembly Building (CAB), a Centrifuge Utility Building (CUB) with offices and control room, annexes for purification, supply and extraction of uranium hexafluoride (UF 6 ), modules containing the halls that house the centrifuge cascades. The modular design of the Georges Besse II plant will allow production in the first cascade where as the others cascades are build. The first cascade should be operational in the first half of 2009. At an overall cost of 3 billion euros, this project is one of the largest investments of the decade in France On November 24, 2003, AREVA and URENCO signed an agreement under which AREVA would buy 50% of the shares in the Enrichment Technology Company (ETC), which designs and manufactures centrifuges
Structural remains at the early mediaeval fort at Raibania, Orissa
Directory of Open Access Journals (Sweden)
Bratati Sen
2013-11-01
Full Text Available The fortifications of mediaeval India occupy an eminent position in the history of military architecture. The present paper deals with the preliminary study of the structural remains at the early mediaeval fort at Raibania in the district of Balasore in Orissa. The fort was built of stone very loosely kept together. The three-walled fortification interspersed by two consecutive moats, a feature evidenced at Raibania, which is unparallel in the history of ancient and mediaeval forts and fortifications in India. Several other structures like the Jay-Chandi Temple Complex, a huge well, numerous tanks and remains of an ancient bridge add to the uniqueness of the Fort in the entire eastern region.
Le Fort I Maxillary Advancement Using Distraction Osteogenesis
Combs, Patrick D.; Harshbarger, Raymond J.
2014-01-01
Treatment of maxillary hypoplasia has traditionally involved conventional Le Fort I osteotomies and advancement. Advancements of greater than 10 mm risk significant relapse. This risk is greater in the cleft lip and palate population, whose anatomy and soft tissue scarring from prior procedures contributes to instability of conventional maxillary advancement. Le Fort I advancement with distraction osteogenesis has emerged as viable, stable treatment modality correction of severe maxillary hypoplasia in cleft, syndromic, and noncleft patients. In this article, the authors provide a review of current data and recommendations concerning Le Fort I advancement with distraction osteogenesis. In addition, they outline their technique for treating severe maxillary hypoplasia with distraction osteogenesis using internal devices. PMID:25383054
Case Study: Fort Mill High School--A Culture of Continuous Improvement
Southern Regional Education Board (SREB), 2014
2014-01-01
This is the latest in a series of case studies highlighting best practices High Schools That Work (HSTW) network schools and districts are implementing to prepare students better for further studies and careers. Fort Mill High School is in Fort Mill, South Carolina, an outlying suburb of Charlotte, North Carolina. Fort Mill links high quality…
Hydrologic Analysis of Fort Leonard Wood, Missouri
2015-08-01
drainage areas are different, hydrological analysis will be conducted on the two basins individually. The results of the two analyses will be combined to...ER D C TR -1 5- 4 Environmental Quality and Installations Hydrologic Analysis of Fort Leonard Wood, Missouri En gi ne er R es ea rc h...Environmental Quality and Installations ERDC TR-15-4 August 2015 Hydrologic Analysis of Fort Leonard Wood, Missouri Michael L. Follum, Darla C. McVan
DEFF Research Database (Denmark)
Reitan, Rolf
Bogen er en kritisk nærlæsning af Gérard Genettes Discours du récit og viser, hvorden den franske teoretiker løser og forenkler en række centrale problemer i traditionel fortælleteori, idet han uudtalt forudsætter et fiktionsbegreb, som han eksplicit afviser som narratologisk relevant. Det...
Fort Valley's early scientists: A legacy of distinction
Andrew J. Sanchez Meador; Susan D. Olberding
2008-01-01
When the Riordan brothers of Flagstaff, Arizona, asked Gifford Pinchot to determine why there was a deficit in ponderosa pine seedlings, neither party understood the historical significance of what they were setting in motion for the field of forest research. The direct result of that professional favor was the establishment of the Fort Valley Experiment Station (Fort...
International Nuclear Information System (INIS)
Marshall, A.C.; Brown, J.R.
1975-01-01
A description is given of a test to measure the axial flux distribution at several radial locations in the Fort St. Vrain core representing unrodded, rodded, and partially rodded regions. The measurements were intended to verify the calculational accuracy of the three-dimensional calculational model used to compute axial power distributions for the Fort St. Vrain core. (U.S.)
Limb anomalies in DiGeorge and CHARGE syndromes
Energy Technology Data Exchange (ETDEWEB)
Prasad, C.; Quackenbush, E.J.; Whiteman, D.; Korf, B. [Harvard Medical School, Boston, MA (United States)
1997-01-20
Limb anomalies are not common in the DiGeorge or CHARGE syndromes. We describe limb anomalies in two children, one with DiGeorge and the other with CHARGE syndrome. Our first patient had a bifid left thumb, Tetralogy of Fallot, absent thymus, right facial palsy, and a reduced number of T-cells. A deletion of 22q11 was detected by fluorescence in situ hybridization (FISH). The second patient, with CHARGE syndrome, had asymmetric findings that included right fifth finger clinodactyly, camptodactyly, tibial hemimelia and dimpling, and severe club-foot. The expanded spectrum of the DiGeorge and CHARGE syndromes includes limb anomalies. 14 refs., 4 figs.
Phenomenological dynamics of loop quantum cosmology in Kantowski-Sachs spacetime
International Nuclear Information System (INIS)
Chiou, D.-W.
2008-01-01
The fundamental theory and the semiclassical description of loop quantum cosmology (LQC) have been studied in the Friedmann-Robertson-Walker and Bianchi I models. As an extension to include both anisotropy and intrinsic curvature, this paper investigates the cosmological model of Kantowski-Sachs spacetime with a free massless scalar field at the level of phenomenological dynamics with the LQC discreteness corrections. The LQC corrections are implemented in two different improved quantization schemes. In both schemes, the big bang and big crunch singularities of the classical solution are resolved and replaced by the big bounces when the area or volume scale factor approaches the critical values in the Planck regime measured by the reference of the scalar field momentum. Symmetries of scaling are also noted and suggest that the fundamental spatial scale (area gap) may give rise to a temporal scale. The bouncing scenarios are in an analogous fashion of the Bianchi I model, naturally extending the observations obtained previously.
Bruneder, Simon; Wallner, Jürgen; Weiglein, Andreas; Kmečová, Ĺudmila; Egger, Jan; Pilsl, Ulrike; Zemann, Wolfgang
2018-05-02
Osteotomies of the Le Fort I segment are routine operations with low complication rates. Ischemic complications are rare, but can have severe consequences that may lead to avascular bone necrosis of the Le Fort I segment. Therefore the aim of this study was to investigate the blood supply and special arterial variants of the Le Fort I segment responsible for arterial hypoperfusion or ischemic avascular necrosis after surgery. The arterial anatomy of the Le Fort I segment's blood supply using 30 halved human cadaver head specimens was analyzed after complete dissection until the submicroscopic level. In all specimens the arterial variants of the Le Fort I segment and also the arterial diameters measured at two points were evaluated. The typical known vascularization pattern was apparent in 90% of all specimens, in which the ascending palatine (D1: 1,2 mm ± 0,34 mm; D2: 0,8 mm ± 0,34 mm) and ascending pharyngeal artery (D1: 1,3 mm ± 0,58 mm; D2: avascular segment necrosis after surgery. An individualized operation plan may prevent ischemic complications in at-risk patients. Copyright © 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
Georges Paillard 1932-2004 - French version only
2004-01-01
J'ai eu le plaisir de rencontrer Georges en juillet 1959 au groupe Magnet de la division PS au moment où le centième et dernier aimant venait d'être installé dans l'anneau. Le groupe commençait déjà à s'orienter vers de nouveaux projets et mon premier travail avec Georges consista dans des essais de tubes flash de puissance pour la future chambre à bulles. Ensuite, bien que travaillant dans des domaines différents, mais toujours dans les mêmes divisions, nous ne nous sommes jamais perdus de vue. J'ai rencontré Georges en janvier 1961 au laboratoire d'électronique de la division NPA. Georges avait déjà six ans de CERN : c'était un ancien. Au début, il y eut la chambre à « boules ». Le chef de la division NPA, M. Colin Ramm, australien, éprouvait une certaine difficulté à prononcer le « u » français et une machine classique de la physique nucléaire est devenue l'unique chambre à « boules » jamais construite. Chambre qui connut son heure de gloire puisqu'elle enreg...
Tay-Sachs disease in Jacob sheep.
Torres, Paola A; Zeng, Bai Jin; Porter, Brian F; Alroy, Joseph; Horak, Fred; Horak, Joan; Kolodny, Edwin H
2010-12-01
Autopsy studies of four Jacob sheep dying within their first 6-8 months of a progressive neurodegenerative disorder suggested the presence of a neuronal storage disease. Lysosomal enzyme studies of brain and liver from an affected animal revealed diminished activity of hexosaminidase A (Hex A) measured with an artificial substrate specific for this component of β-hexosaminidase. Absence of Hex A activity was confirmed by cellulose acetate electrophoresis. Brain lipid analyses demonstrated the presence of increased concentrations of G(M2)-ganglioside and asialo-G(M2)-ganglioside. The hexa cDNA of Jacob sheep was cloned and sequenced revealing an identical number of nucleotides and exons as in human HexA and 86% homology in nucleotide sequence. A missense mutation was found in the hexa cDNA of the affected sheep caused by a single nucleotide change at the end of exon 11 resulting in skipping of exon 11. Transfection of normal sheep hexa cDNA into COS1 cells and human Hex A-deficient cells led to expression of Hex S but no increase in Hex A indicating absence of cross-species dimerization of sheep Hex α-subunit with human Hex β-subunits. Using restriction site analysis, the heterozygote frequency of this mutation in Jacob sheep was determined in three geographically separate flocks to average 14%. This large naturally occurring animal model of Tay-Sachs disease is the first to offer promise as a means for trials of gene therapy applicable to human infants. Copyright © 2010 Elsevier Inc. All rights reserved.
78 FR 17087 - Special Local Regulation; New River Raft Race, New River; Fort Lauderdale, FL
2013-03-20
...-AA08 Special Local Regulation; New River Raft Race, New River; Fort Lauderdale, FL AGENCY: Coast Guard... on the New River in Fort Lauderdale, Florida during the Rotary Club of Fort Lauderdale New River Raft... States during the Rotary Club of Fort Lauderdale New River Raft Race. On March 23, 2013, Fort Lauderdale...
40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.
2010-07-01
... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Metropolitan Fort Smith Interstate Air... Air Quality Control Regions § 81.63 Metropolitan Fort Smith Interstate Air Quality Control Region. The Metropolitan Fort Smith Interstate Air Quality Control Region (Arkansas-Oklahoma) has been revised to consist...
Energy Technology Data Exchange (ETDEWEB)
Mark, Brian L.; Mahuran, Don J.; Cherney, Maia M.; Zhao, Dalian; Knapp, Spencer; James, Michael N.G.
2010-12-01
In humans, two major {beta}-hexosaminidase isoenzymes exist: Hex A and Hex B. Hex A is a heterodimer of subunits {alpha} and {beta} (60% identity), whereas Hex B is a homodimer of {beta}-subunits. Interest in human {beta}-hexosaminidase stems from its association with Tay-Sachs and Sandhoff disease; these are prototypical lysosomal storage disorders resulting from the abnormal accumulation of G{sub M2}-ganglioside (G{sub M2}). Hex A degrades G{sub M2} by removing a terminal N-acetyl-D-galactosamine ({beta}-GalNAc) residue, and this activity requires the G{sub M2}-activator, a protein which solubilizes the ganglioside for presentation to Hex A. We present here the crystal structure of human Hex B, alone (2.4 {angstrom}) and in complex with the mechanistic inhibitors GalNAc-isofagomine (2.2 {angstrom}) or NAG-thiazoline (2.5 {angstrom}). From these, and the known X-ray structure of the G{sub M2}-activator, we have modeled Hex A in complex with the activator and ganglioside. Together, our crystallographic and modeling data demonstrate how {alpha} and {beta}-subunits dimerize to form either Hex A or Hex B, how these isoenzymes hydrolyze diverse substrates, and how many documented point mutations cause Sandhoff disease ({beta}-subunit mutations) and Tay-Sachs disease ({alpha}-subunit mutations).
Moving towards first science with the St. George recoil separator
Meisel, Zachary; Berg, G. P. A.; Gilardy, G.; Moran, M.; Schmitt, J.; Seymour, C.; Stech, E.; Couder, M.
2015-10-01
The St. George recoil mass separator has recently been coupled to the 5MV St. Ana accelerator at the University of Notre Dame's Nuclear Science Lab. St. George is a unique tool designed to measure radiative alpha-capture reactions for nuclei up to A = 40 in inverse kinematics in order to directly obtain cross sections required for astrophysical models of stellar and explosive helium burning. Commissioning of St. George is presently taking place with primary beams of hydrogen, helium, and oxygen. In this presentation, results will be shown for the measured energy acceptance of St. George, which compare favorably to COSY results when employing the calculated optimal ion-optical settings. Additionally, future plans will be discussed, such as assessing the angular acceptance of St. George and the re-integration of HiPPO at the separator target position to provide a dense, windowless helium gas-jet target. The material presented in this work is partially supported by the National Science Foundation Grant No. 1419765.
Energy Technology Data Exchange (ETDEWEB)
Schroer, Bert
2006-04-15
The holographic encoding is generalized to subalgebras of QFT localized in double cones. It is shown that as a result of this radically different spacetime encoding the modular group acts geometrically on the holographic image. As a result we obtain a formula for localization entropy which is identical to the previously derived formula for the wedge-localized subalgebra. The symmetry group in the holographic encoding turns out to be the Bondi-Metzner-Sachs group. (author)
Hunter, Robert S.
2000-01-01
Presents an art project in which students create postmodern portraits of George Washington in the style of Andy Warhol's pop-art portraits. Each portrait incorporates a fact and six symbols associated with Washington. Describes the project in detail and lists the materials and project objectives. (CMK)
Fort St. Vrain circulator operating experience
International Nuclear Information System (INIS)
Brey, H.L.
1988-01-01
Fort St. Vrain, on the system of Public Service Company of Colorado, is the only high-temperature gas-cooled power reactor in the United States. Four helium circulators are utilized in this plant to transfer heat from the reactor to the steam generators. These unique machines have a single stage axial flow helium compressor driven by a single stage steam turbine. A single stage water driven (pelton wheel) turbine is the back-up drive utilizing either feed water, condensate, or fire water as the driving fluid. Developmental testing of the circulators was accomplished prior to installation into Fort St. Vrain. A combined machine operating history of approximately 250,000 hours has shown these machines to be of conservative design and proven mechanical integrity. However, many problems have been encountered in operating the complex auxiliaries which are necessary for successful circulator and plant operation. It has been 15 years since initial installation of the circulators occurred at Fort St. Vrain. During this time, a number of significant issues had to be resolved dealing specifically with machine performance. These events include cavitation damage of the pelton wheels during the initial plant hot functional testing, cracks in the water turbine buckets and cervic coupling, static shutdown seal bellows failure, and, most recently, degradation of components within the steam drive assembly. Unreliable operation particularly with the circulator auxiliaries has been a focus of attention by Public Service Company of Colorado. Actions to replace or significantly modify the existing circulators and their auxiliaries are currently awaiting decisions concerning the long-term future of the Fort St. Vrain plant. (author). 10 refs, 7 figs, 2 tabs
Fort St. Vrain circulator operating experience
Energy Technology Data Exchange (ETDEWEB)
Brey, H. L.
1988-08-15
Fort St. Vrain, on the system of Public Service Company of Colorado, is the only high-temperature gas-cooled power reactor in the United States. Four helium circulators are utilized in this plant to transfer heat from the reactor to the steam generators. These unique machines have a single stage axial flow helium compressor driven by a single stage steam turbine. A single stage water driven (pelton wheel) turbine is the back-up drive utilizing either feed water, condensate, or fire water as the driving fluid. Developmental testing of the circulators was accomplished prior to installation into Fort St. Vrain. A combined machine operating history of approximately 250,000 hours has shown these machines to be of conservative design and proven mechanical integrity. However, many problems have been encountered in operating the complex auxiliaries which are necessary for successful circulator and plant operation. It has been 15 years since initial installation of the circulators occurred at Fort St. Vrain. During this time, a number of significant issues had to be resolved dealing specifically with machine performance. These events include cavitation damage of the pelton wheels during the initial plant hot functional testing, cracks in the water turbine buckets and cervic coupling, static shutdown seal bellows failure, and, most recently, degradation of components within the steam drive assembly. Unreliable operation particularly with the circulator auxiliaries has been a focus of attention by Public Service Company of Colorado. Actions to replace or significantly modify the existing circulators and their auxiliaries are currently awaiting decisions concerning the long-term future of the Fort St. Vrain plant. (author). 10 refs, 7 figs, 2 tabs.
How Do Le Fort-Type Fractures Present in a Pediatric Cohort?
Macmillan, Alexandra; Lopez, Joseph; Luck, J D; Faateh, Muhammad; Manson, Paul; Dorafshar, Amir H
2018-05-01
Le Fort-type fractures are very rare in children, and there is a paucity of literature presenting their frequency and characteristics. The purpose of this study was to determine the etiology, frequency, and fracture patterns of children with severe facial trauma associated with pterygoid plate fractures in a pediatric cohort. We performed a retrospective cohort study of all children aged younger than 16 years with pterygoid plate and facial fractures who presented to our institute between 1990 and 2010. Patient charts and radiologic records were reviewed for demographic and fracture characteristics. Patients were categorized into 2 groups as per facial fracture pattern: non-Le Fort-type fractures (group A) and Le Fort-type fractures (group B). Other variables including dentition age, frontal sinus development, mechanism of injury, injury severity, and concomitant injuries were recorded. Univariate methods were used to compare groups. We identified 24 children; 25% were girls, and 20.8% were of nonwhite race. Most presented with Le Fort-type fracture patterns (group B, 66.7%). Age was significantly different between group A and group B (mean, 5.9 years and 9.9 years, respectively; P = .009). No significant differences in Injury Severity Score, rate of operative repair, and length of stay were found between groups. Most children with severe facial fractures and pterygoid plate fractures presented with Le Fort-type fracture patterns in our cohort. The mean age of children with Le Fort-type fractures was greater than in those with non-Le Fort-type patterns. However, Le Fort-type fractures did occur in younger children with deciduous and mixed dentition. Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
Pathological alterations typical of human Tay-Sachs disease, in the retina of a deep-sea fish
Fishelson, L.; Delarea, Yacov; Galil, Bella S.
Micrographs of retinas from the deep-sea fish Cataetyx laticeps revealed visual cells containing membranous whorls in the ellipsoids of the inner segments resulting from stretching and modifications of the mitochondria membranes and their cristae. These pathological structures seem to be homologous to the whorls observed in retinas of human carriers of Tay-Sachs disease. This disease, a genetic disorder, is found in humans and some mammals. Our findings in fish suggest that the gene responsible can be found throughout the vertebrate evolutionary tree, possibly dormant in most taxa.
Le Fort I Maxillary Advancement Using Distraction Osteogenesis
Combs, Patrick D.; Harshbarger, Raymond J.
2014-01-01
Treatment of maxillary hypoplasia has traditionally involved conventional Le Fort I osteotomies and advancement. Advancements of greater than 10 mm risk significant relapse. This risk is greater in the cleft lip and palate population, whose anatomy and soft tissue scarring from prior procedures contributes to instability of conventional maxillary advancement. Le Fort I advancement with distraction osteogenesis has emerged as viable, stable treatment modality correction of severe maxillary hyp...
International Nuclear Information System (INIS)
1994-05-01
An aerial radiological survey was conducted over the Fort Calhoun Nuclear Power Plant in Fort Calhoun, Nebraska, during the period June 19 through June 28, 1993. The survey was conducted at an altitude of 150 feet (46 meters) over a 25-square-mile (65-square-kilometer) area centered on the power station. The purpose of the survey was to document the terrestrial gamma radiation environment of the Fort Calhoun Nuclear Power Plant and surrounding area. The results of the aerial survey are reported as inferred gamma radiation exposure rates at 1 meter above ground level in the form of a contour map. Outside the plant boundary, exposure rates were found to vary between 6 and 12 microroentgens per hour and were attributed to naturally-occurring uranium, thorium, and potassium. The aerial data were compared to ground-based benchmark exposure rate measurements and radionuclide assays of soil samples obtained within the survey boundary. The ground-based measurements were found to be in good agreement with those inferred from the aerial measuring system. A previous survey was conducted on August 9 and 10, 1972, before the plant began operation. Exposure rates measured in both surveys were consistent with normal terrestrial background
EDITORIAL: George W Series Memorial Essays
Dodd, J. N.
1997-01-01
I would like to recall my experiences when I joined George Series when on study leave from the University of Otago in 1959. Like George, we had decided, some years previously, to pursue the line of research opened up by the double-resonance experiment of Brossel and Bitter. Up to that time both groups had been applying the new technique to traditional spectroscopic problems, those of measuring the fine structure, hyperhe structure, g-factors and nuclear moments. But here, in Oxford, was something new and exciting - experiments that studied the nature of light itself, questioning some long-held views. George had come to the view that, in a double-resonance experiment, one could demonstrate the inner coherence that could exist between superposition states of an atom. He, and his students Wilf Fox and Mike Taylor, had already obtained promising evidence; but he needed more definite results if he was going to allay the doubts and suspicions of some others in the Clarendon. At the time, people generally thought that light, being a superposition of radiations from many atoms with no obvious phase relation to each other, was an incoherent wave phenomenon. One could observe small scale coherence (for example, in the Young interference experiment) but it would be largely concealed by the incoherent nature of the radiation from many atoms in a source. In the experiments that had been performed the coherence was introduced between a pair of excited states (Zeeman sub-states) by the application of an oscillating magnetic field - was it not likely, according to the doubters, that the modulation observed in the fluorescence was due to "pick-up" in the amplifiers from the source of oscillations? George had to prove that this was not the cause. I well remember him saying at the time "I have a hunch that I am correct". That typified his approach to physics. The work of 1959 demonstrated beyond all doubt that substantial coherence, manifested as strong beats in the intensity of the
Fort Carson Wind Resource Assessment
Energy Technology Data Exchange (ETDEWEB)
Robichaud, R.
2012-10-01
This report focuses on the wind resource assessment, the estimated energy production of wind turbines, and economic potential of a wind turbine project on a ridge in the southeastern portion of the Fort Carson Army base.
Nutritional advice from George Orwell
DEFF Research Database (Denmark)
Larsen, Morten Hedegaard
2015-01-01
is historical descriptions (in the form of excerpts) from George Orwell's 1937 book “The Road to Wigan Pier” on the living conditions of the British working classes. These descriptions will be aligned with results from contemporary research into nutritional behaviour. Strong similarities are identified between...... George Orwell's historical descriptions of the working-class's unhealthy diet and the findings from contemporary research into nutritional behaviour of people with a low socio-economic status. The article, on this basis, argues that certain social mechanisms influencing nutritional choices are readily...... identifiable across disciplines, and even partly reproduced in different historical, social and spatial contexts, with stronger negative (ill health) consequences for people with low socio-economic status especially. Finally the article discusses how social mechanisms affecting our nutritional choices could...
Georg Cantor: habitar lo eterno
Penagos, Juan Manuel Rodríguez
2002-01-01
Este artículo pone en discusión la relación entre estructura psíquica y la producción lógica del delirio; para ello, parte de un matemático alemán llamado Georg Cantor. Aquí se discute la relación entre la producción matemática y la instalación de su psicosis. Este artigo coloca em discussão a relação entre estrutura psíquica e a produção lógica do delírio, partindo de um matemático alemão chamado Georg Cantor. Discutese ainda a relação entre a produção matemática e a instalação de sua psi...
Renewable Energy Opportunities at Fort Sill, Oklahoma
Energy Technology Data Exchange (ETDEWEB)
Boyd, Brian K.; Hand, James R.; Horner, Jacob A.; Orrell, Alice C.; Russo, Bryan J.; Weimar, Mark R.; Nesse, Ronald J.
2011-03-31
This document provides an overview of renewable resource potential at Fort Sill, based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. This effort focuses on grid-connected generation of electricity from renewable energy sources and on ground source heat pumps for heating and cooling buildings. The effort was funded by the U.S. Army Installation Management Command (IMCOM) as follow-on to the 2005 Department of Defense (DoD) Renewables Assessment. The site visit to Fort Sill took place on June 10, 2010.
Renewable Energy Opportunities at Fort Polk, Louisiana
Energy Technology Data Exchange (ETDEWEB)
Solana, Amy E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Boyd, Brian K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Horner, Jacob A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gorrissen, Willy J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Orrell, Alice C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Weimar, Mark R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hand, James R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Russo, Bryan J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Williamson, Jennifer L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
2010-11-17
This document provides an overview of renewable resource potential at Fort Polk, based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. This effort focuses on grid-connected generation of electricity from renewable energy sources and also on ground source heat pumps for heating and cooling buildings. The effort was funded by the U.S. Army Installation Management Command (IMCOM) as follow-on to the 2005 Department of Defense (DoD) Renewables Assessment. The site visit to Fort Polk took place on February 16, 2010.
Indian Academy of Sciences (India)
Home; Fellowship. Fellow Profile. Elected: 2003 Honorary. Dodson, Prof. George Guy FRS. Date of birth: 13 January 1937. Date of death: 24 December 2012. Last known address: Division of Protein Structure, National Institute for Medical, Research, Mill Hill, London NW7 1AA, U.K.. YouTube; Twitter; Facebook; Blog ...
Fort Independence: An Eighteenth-Century Frontier Homesite and Militia Post in South Carolina.
1982-12-01
included in this instance as a condiment , but it could also indicate that the Fort Independence garrison was familiar with the strategy employed by the Fort...archeological investigation of Fort Charlotte, McCormick County, South Carolina. Notebook, Institute of Archeology and Anthropology, University of South
The 1995 Georges Bank Stratification Study and Moored Array Measurements
National Research Council Canada - National Science Library
Alessi, C
2001-01-01
.... GLOBEC Northwest Atlantic/Georges Bank field program. The GBSS was designed to investigate the physical processes which control the seasonal development of stratification along the southern flank of Georges Bank during spring and summer...
George Sandi "Consuelo" / Ott Ojamaa
Ojamaa, Ott, 1926-1996
2010-01-01
Arvustus: Sand, George, pseud. Consuelo. 1-2. : romaan / [prantsuse keelest tõlkinud Leili-Maria Kask järelsõna ja märkused: Ott Ojamaa]. Tallinn : Eesti Riiklik Kirjastus, 1961. (Suuri sõnameistreid). 2. tr. ilmus 1988. a.
George Sigerson: Charcot's translator.
Lyons, J B
1997-04-01
Senator George Sigerson (1836-1925), Dublin's first neurologist, was also a significant contributor to Anglo-Irish literature. His medical career and literary accomplishments are outlined, the focus of the article being Sigerson's friendly relationship with Charcot (with whom he corresponded), and whose Leçons sur les maladies du système nerveux he translated.
Goldstein, Evan R.
2008-01-01
In this article, a noted linguist reflects on his tumultuous foray into politics. For years George P. Lakoff has been at the center of some of the biggest intellectual disagreements in linguistics (most famously with Noam Chomsky) and has helped create an important interdisciplinary field of study, cognitive linguistics, that is reshaping people's…
Indian Academy of Sciences (India)
Home; Fellowship. Fellow Profile. Elected: 1984 Honorary. Series, Prof. George William. Date of birth: 22 February 1920. Date of death: 2 January 1995. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...
En fascinerende fortælling om det 20. århundredes musik
DEFF Research Database (Denmark)
Bonde, Lars Ole
2011-01-01
Anmeldelse af Karl Aage Rasmussen: Musik i det tyvende århundrede: En fortælling. Gyldendal 2011.......Anmeldelse af Karl Aage Rasmussen: Musik i det tyvende århundrede: En fortælling. Gyldendal 2011....
Analysis of Delayed Sea Breeze Onset for Fort Ord Prescribed Burning Operations
2015-12-01
DELAYED SEA BREEZE ONSET FOR FORT ORD PRESCRIBED BURNING OPERATIONS by Dustin D. Hocking December 2015 Thesis Advisor: Wendell Nuss Second...AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE ANALYSIS OF DELAYED SEA BREEZE ONSET FOR FORT ORD PRESCRIBED BURNING OPERATIONS 5...release; distribution is unlimited 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) The U.S. Army conducts prescribed burns at Fort Ord
77 FR 1716 - James River National Wildlife Refuge, Prince George County, VA
2012-01-11
... River National Wildlife Refuge, Prince George County, VA AGENCY: Fish and Wildlife Service, Interior... (the refuge, NWR), which is located in Prince George County, Virginia. We provide this notice in... River NWR, in Prince George County, Virginia. This notice complies with our CCP policy to advise other...
Hawking, Lucy
2016-01-01
George and his best friend, Annie have been selected as junior astronauts - part of a programme that trains up young people for a trip to Mars in the future. This is everything they've ever wanted - they get to be a part of up-to-the minute space discoveries and meet a bunch of new friends who are as fascinated by the universe as they are. But when they arrive at space camp, George and Annie quickly learn that strange things are happening - on Earth as well as up in our skies. Mysterious space missions are happening in secret, and the astronaut training they're undertaking gets scarier and scarier . . . The fifth adventure in this series by Lucy and Stephen Hawking - also containing up-to-the-minute scientific facts and information by the world's leading scientists.
Three novel mutations in Iranian patients with Tay-Sachs disease.
Jamali, Solmaz; Eskandari, Nasim; Aryani, Omid; Salehpour, Shadab; Zaman, Talieh; Kamalidehghan, Behnam; Houshmand, Massoud
2014-01-01
Tay-Sachs disease (TSD), or GM2 gangliosidosis, is a lethal autosomal recessive neurodegenerative disorder, which is caused by a deficiency of beta-hexosaminidase A (HEXA), resulting in lysosomal accumulation of GM2 ganglioside. The aim of this study was to identify the TSD-causing mutations in an Iranian population. In this study, we examined 31 patients for TSD-causing mutations using PCR, followed by restriction enzyme digestion. Molecular genetics analysis of DNA from 23 patients of TSD revealed mutations that has been previously reported, including four-base duplications c.1274_1277dupTATC in exon 11 and IVS2+1G>A, deletion TTAGGCAAGGGC in exon 10 as well as a few novel mutations, including C331G, which altered Gln>Glu in HEXB, A>G, T>C, and p.R510X in exon 14, which predicted a termination codon or nonsense mutation. In conclusion, with the discovery of these novel mutations, the genotypic spectrum of Iranian patients with TSD disease has been extended and could facilitate definition of disease-related mutations.
Haghighi, Alireza; Rezazadeh, Jamileh; Shadmehri, Azam Ahmadi; Haghighi, Amirreza; Kornreich, Ruth; Desnick, Robert J
2011-09-01
The β-hexosaminidase A (HEXA) mutations in the first reported cases of infantile Tay-Sachs disease in the Persian population were identified in two unrelated consanguineous families. The clinical diagnoses of the affected infants were confirmed by their markedly deficient levels of HEXA activity in plasma or peripheral leukocytes. The specific causative mutation in each family was determined by sequencing the HEXA alleles in both sets of related parents. Two mutations were identified: c.1A>G (p.MIV), which obliterated the initiating methionine in codon 1, and c.1177C>T (p.R393X), which predicted a termination codon or nonsense mutation.
Fort Peck-Wolf Point transmission line project, Montana
International Nuclear Information System (INIS)
1992-01-01
The primary objective of the project is to replace the existing 36-mile Fort Peck-Wolf Point transmission line which has reached the end of its useful service life. Presently, the overall condition of this existing section of the 47-year-old line is poor. Frequent repairs have been required because of the absence of overhead ground wires. The continued maintenance of the line will become more expensive and customer interruptions will persist because of the damage due to lightning. The expense of replacing shell rotted poles, and the concern for the safety of the maintenance personnel because of hazards caused by severe shell rot are also of primary importance. The operational and maintenance problems coupled with power system simulation studies, demonstrate the need for improvements to the Wolf Point area to serve area loads. Western's Wolf Point Substation is an important point of interconnection for the power output from the Fort Peck Dam to area loads as far away as Williston, North Dakota. The proposed transmission line replacement would assure that there will continue to be reliable transmission capacity available to serve area electrical loads, as well as provide a reliable second high-voltage transmission path from the Fort Peck generation to back-up a loss of the Fort Peck-Wolf Point 115-kV Line No. 1
Georges et les trésors du cosmos
Hawking, Lucy; Parsons, Gary
2011-01-01
Les voisins excentriques de Georges, Annie et Eric, ont déménagé en Floride à l'agence Spatiale Globale. Là-bas, Eric s'occupe de son nouveau robot, Homer, qui doit détécter les signes de vie sur Mars. Mais bientôt, Georges reçoit un e-mail : Annie lui demande de la rejoindre au plus vite pour une " mission cosmique " secrète. La jeune fille est persuadée qu'il se passe de drôles de choses sur Mars, car Homer vient de recevoir un message extraterrestre ! Georges et Anne (avec l'aide d'Emmett, un petit garçon bizarre) décident de réparer Cosmos, leur super-ordinateur, et d'aller voir par eux-mêmes... Emmaillotés dans des combinaisons spéciales, ils se lancent alors dans une fabuleuse chasse aux trésors sur Mars, sur les lunes de Saturne, puis sur Titan, avant de se perdre en orbite autour d'Alpha Centauri B... Mais avant de pouvoir élucider le mystère du message extraterrestre, Georges et Annie devront se livrer à une bataille spatiale acharnée qui mettra leur vie en danger, ainsi que ce...
George Mikenberg honoured by the Sharing Knowledge Foundation
CERN Bulletin
2016-01-01
The Sharing Knowledge Foundation Prize was presented to the ATLAS physicist at a ceremony on 18 March. ATLAS physicist George Mikenberg receives the Sharing Knowledge Foundation Prize. From left to right: Peter Jenni, former ATLAS Spokesperson, Rolf Heuer, former CERN Director-General, Frédérick Bordry, CERN Director for Accelerators and Technology, George Mikenberg, Patrick Fassnacht, CERN International Relations sector, Eliane Jacot-Des-Combes Mikenberg, Herwig Schopper, former CERN Director-General, Constantin Lanaras, treasurer of the Sharing Knowledge Foundation, Robert Klapisch, President of the Sharing Knowledge Foundation, Federico Saldana, logistical support, Catherine Cesarsky, Vice-President of the CERN Council, Eliezer Rabinovici, Vice-President of the CERN Council and of SESAME. (Image: Sophia Bennett/CERN) The Sharing Knowledge Foundation awarded its 2016 prize to George Mikenberg, a member of the LHC's ATLAS experiment who has been...
Targeting Net Zero Energy at Fort Carson: Assessment and Recommendations
Energy Technology Data Exchange (ETDEWEB)
Anderson, K.; Markel, T.; Simpson, M.; Leahey, J.; Rockenbaugh, C.; Lisell, L.; Burman, K.; Singer, M.
2011-10-01
The U.S. Army's Fort Carson installation was selected to serve as a prototype for net zero energy assessment and planning. NREL performed the comprehensive assessment to appraise the potential of Fort Carson to achieve net zero energy status through energy efficiency, renewable energy, and electric vehicle integration. This report summarizes the results of the assessment and provides energy recommendations. This study is part of a larger cross-laboratory effort that also includes an assessment of renewable opportunities at seven other DoD Front Range installations, a microgrid design for Fort Carson critical loads and an assessment of regulatory and market-based barriers to a regional secure smart grid.
Florin, David A; Lawyer, Phillip; Rowton, Edgar; Schultz, George; Wilkerson, Richard; Davies, Stephen J; Lipnick, Robert; Keep, Lisa
2010-09-01
This report describes two male specimens of the sand fly species Lutzomyia shannoni (Dyar) (Diptera: Psychodidae: Phlebotominae) collected at Fort Rucker, AL, and Fort Campbell, KY, in dry ice-baited light traps during September 2005. The specimens were observed to have anomalies to the number of spines on the gonostyli. The taxonomic keys of Young and Perkins (Mosq. News 44: 263-285; 1984) use the number of spines on the gonostylus in the first couplet to differentiate two major groupings of North American sand flies. The two anomalous specimens were identified as L. shannoni based on the following criteria: (1) both specimens possess antennal ascoids with long, distinct proximal spurs (a near diagnostic character of L. shannoni in North America), (2) the sequences of the partial cytochrome c oxidase subunit 1 gene from both specimens indicated L. shannoni, and (3) the sequences of the internal transcribed spacer 2 molecular marker from both specimens indicated L. shannoni. The anomalous features are fundamentally different from each other as the Fort Rucker specimen possesses a fifth spine (basally located) on just one gonostylus, whereas the Fort Campbell specimen possesses five spines (extra spines subterminally located) on both gonostyli. Because the gonostyli are part of the external male genitalia, anomalies in the number of spines on the gonostyli may have serious biological consequences, such as reduced reproductive success, for the possessors. These anomalies are of taxonomic interest as the specimens could easily have been misidentified using available morphological keys.
76 FR 68625 - Establishment of the Fort Monroe National Monument
2011-11-07
... period of slavery in the colonies and, later, this Nation. Two hundred and forty-two years later, Fort... 1863. Thus, Old Point Comfort marks both the beginning and end of slavery in our Nation. The Fort... North Beach area lies the only undeveloped shoreline remaining on Old Point Comfort, providing modern...
Inventory of Forts in Indonesia
Rinandi, N.; Suryaningsih, F.
2015-08-01
The great archipelago in Indonesia with its wealthy and various nature, the products and commodities of tropic agriculture and the rich soil, was through the centuries a region of interest for other countries all over the world. For several reasons some of these countries came to Indonesia to establish their existence and tried to monopolize the trading. These countries such as the Portuguese, the Spanish, the Dutch and the British built strengthened trade stations which later became forts all over Indonesia to defend their interest. The archipelago of Indonesia possesses a great number of fortification-works as legacies of native rulers and those which were built by European trading companies and later became colonial powers in the 16th to the 19th centuries. These legacies include those specific structures built as a defence system during pre and within the period of World War II. These fortresses are nowadaysvaluable subjects, because they might be considered as shared heritage among these countries and Indonesia. It's important to develop a vision to preserve these particular subjects of heritage, because they are an interesting part of the Indonesian history and its cultural treasures. The Government of the Republic of Indonesia has national program to compile a comprehensive documentation of the existing condition of these various types of forts as cultural heritage. The result of the 3 years project was a comprehensive 442 forts database in Indonesia, which will be very valuable to the implementation of legal protection, preservation matters and adaptive re-use in the future.
Cranial nerve injury after Le Fort I osteotomy.
Kim, J-W; Chin, B-R; Park, H-S; Lee, S-H; Kwon, T-G
2011-03-01
A Le Fort I osteotomy is widely used to correct dentofacial deformity because it is a safe and reliable surgical method. Although rare, various complications have been reported in relation to pterygomaxillary separation. Cranial nerve damage is one of the serious complications that can occur after Le Fort I osteotomy. In this report, a 19-year-old man with unilateral cleft lip and palate underwent surgery to correct maxillary hypoplasia, asymmetry and mandibular prognathism. After the Le Fort I maxillary osteotomy, the patient showed multiple cranial nerve damage; an impairment of outward movement of the eye (abducens nerve), decreased vision (optic nerve), and paraesthesia of the frontal and upper cheek area (ophthalmic and maxillary nerve). The damage to the cranial nerve was related to an unexpected sphenoid bone fracture and subsequent trauma in the cavernous sinus during the pterygomaxillary osteotomy. Copyright © 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Burkhart, S S; De Beer, J F
2000-10-01
Our goal was to analyze the results of 194 consecutive arthroscopic Bankart repairs (performed by 2 surgeons with an identical suture anchor technique) in order to identify specific factors related to recurrence of instability. Case series. We analyzed 194 consecutive arthroscopic Bankart repairs by suture anchor technique performed for traumatic anterior-inferior instability. The average follow-up was 27 months (range, 14 to 79 months). There were 101 contact athletes (96 South African rugby players and 5 American football players). We identified significant bone defects on either the humerus or the glenoid as (1) "inverted-pear" glenoid, in which the normally pear-shaped glenoid had lost enough anterior-inferior bone to assume the shape of an inverted pear; or (2) "engaging" Hill-Sachs lesion of the humerus, in which the orientation of the Hill-Sachs lesion was such that it engaged the anterior glenoid with the shoulder in abduction and external rotation. There were 21 recurrent dislocations and subluxations (14 dislocations, 7 subluxations). Of those 21 shoulders with recurrent instability, 14 had significant bone defects (3 engaging Hill-Sachs and 11 inverted-pear Bankart lesions). For the group of patients without significant bone defects (173 shoulders), there were 7 recurrences (4% recurrence rate). For the group with significant bone defects (21 patients), there were 14 recurrences (67% recurrence rate). For contact athletes without significant bone defects, there was a 6.5% recurrence rate, whereas for contact athletes with significant bone defects, there was an 89% recurrence rate. (1) Arthroscopic Bankart repairs give results equal to open Bankart repairs if there are no significant structural bone deficits (engaging Hill-Sachs or inverted-pear Bankart lesions). (2) Patients with significant bone deficits as defined in this study are not candidates for arthroscopic Bankart repair. (3) Contact athletes without structural bone deficits may be treated by
Georges Didi-Huberman, Images malgré tout
Shafto, Sally
2008-01-01
« Pour savoir, il faut s’imaginer. »Georges Didi-Huberman Avec son dernier livre, Images malgré tout, l’historien de l’art et philosophe Georges Didi-Huberman nous livre un texte élégamment écrit et divisé en trois mouvements. Il y a d’abord une réimpression de son article, paru auparavant dans le catalogue, Mémoires des camps. Photographies des camps de concentration et d’extermination nazis 1933-1999. Il s’agit d’une lecture phénoménologique de quatre photographies, prises à Auschwitz en ao...
Generation of HEXA-deficient hiPSCs from fibroblasts of a Tay-Sachs disease patient
Directory of Open Access Journals (Sweden)
Zhong Liu
2016-09-01
Full Text Available Human iPSC line TSD-01-hiPSC was generated from fibroblasts of a patient with infantile Tay-Sachs disease (TSD. The patient is compound heterozygous at the HEXA gene by carrying a 1278insTATC allele and an IVS12+1G>C allele. STEMCCA lentivirus, which expresses OCT4, SOX2, KLF4, and c-MYC from a polycistronic transcript, were used for reprogramming. TSD-01-hiPSC express pluripotency markers such as OCT4, SOX2, NANOG, Tra-1-60, and alkaline phosphatase, and can differentiate into tissues from all the three embryonic germ layers. This TSD patient-derived hiPSC line may serve as a valuable in vitro tool for disease modeling and drug test.
Johann Georg Eisen / Indrek Jürjo
Jürjo, Indrek, 1956-2009
1999-01-01
Rets. rmt.: Johann Georg Eisen (1717-1779). Ausgewählte Schriften. Deutsche Volksaufklärung und Leibeigenschaft im Russischen Reich. Hrsg. von Roger Bartlett und Erich Donnert. Marburg : IHerder-Institut, 1998
Fort Valley's early scientists: A legacy of distinction (P-53)
Andrew J. Sanchez Meador; Susan D. Olberding
2008-01-01
When the Riordan brothers of Flagstaff, Arizona asked Gifford Pinchot to determine why there was a deficit in ponderosa pine seedlings, neither party understood the historical significance of what they were setting in motion for the field of forest research. The direct result of that professional favor was the establishment of the Fort Valley Experiment Station (Fort...
Renewable Energy Opportunities at Fort Campbell, Tennessee/Kentucky
Energy Technology Data Exchange (ETDEWEB)
Hand, James R.; Horner, Jacob A.; Kora, Angela R.; Orrell, Alice C.; Russo, Bryan J.; Weimar, Mark R.; Nesse, Ronald J.
2011-03-31
This document provides an overview of renewable resource potential at Fort Campbell, based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. This effort focuses on grid-connected generation of electricity from renewable energy sources and also on ground source heat pumps for heating and cooling buildings. The effort was funded by the U.S. Army Installation Management Command (IMCOM) as follow-on to the 2005 Department of Defense (DoD) Renewables Assessment. The site visit to Fort Campbell took place on June 10, 2010.
Renewable Energy Opportunities at Fort Drum, New York
Energy Technology Data Exchange (ETDEWEB)
Brown, Scott A.; Orrell, Alice C.; Solana, Amy E.; Williamson, Jennifer L.; Hand, James R.; Russo, Bryan J.; Weimar, Mark R.; Rowley, Steven; Nesse, Ronald J.
2010-10-20
This document provides an overview of renewable resource potential at Fort Drum, based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. This effort focuses on grid-connected generation of electricity from renewable energy sources and also on ground source heat pumps for heating and cooling buildings. The effort was funded by the U.S. Army Installation Management Command (IMCOM) as follow-on to the 2005 Department of Defense (DoD) Renewables Assessment. The site visit to Fort Drum took place on May 4 and 5, 2010.
75 FR 21243 - Marine Mammals; Subsistence Taking of Northern Fur Seals; St. George
2010-04-23
... Mammals; Subsistence Taking of Northern Fur Seals; St. George AGENCY: National Marine Fisheries Service... (APA). The Pribilof Island Community of St. George Island, Traditional Council (Council) petitioned... St. George Island to take male fur seal young of the year during the fall. NMFS solicits public...
International Nuclear Information System (INIS)
Levi, H.
1985-01-01
George de Hevesy (1875-1966) worked with Rutherford in Manchester in the early 1900's and with Niels Bohr in Denmark after the first world war. With Coster he discovered an unknown element, later named Hafrivm. In the 1930's he moved to Copenhagen and developed radiotracer techniques using the new artificially produced radioisotopes. This work found wide application in medicine and biology and other branches of science and technology and for his pioneer work de Hevesy was awarded a Nobel Prize in 1944. (UK)
Microgrid Enabled Distributed Energy Solutions (MEDES) Fort Bliss Military Reservation
2014-02-01
FINAL REPORT Microgrid Enabled Distributed Energy Solutions (MEDES) Fort Bliss Military Reservation ESTCP Project EW-201140 FEBRUARY...TITLE AND SUBTITLE Microgrid Enabled Distributed Energy Solutions (MEDES) 5a. CONTRACT NUMBER W912HQ-11-C-0082 Fort Bliss, Texas...Lockheed Martin’s Intelligent Microgrid Solution can provide more energy security while also lowering electric utility costs and greenhouse gas emissions
Obituary: George Hamilton Bowen Jr. (1925-2009)
Willson, Lee Anne; Struck, Curtis
2011-12-01
Our colleague and collaborator George Hamilton Bowen, Jr., passed away November 1, 2009 in Ames, Iowa. George was born June 20, 1925 in Tulsa, Oklahoma to George and Dorothy (Huntington) Bowen. He married Marjorie Brown June 19, 1948 in Redondo Beach, California; they had five children, with eight grandchildren and five great-grandchildren at the time of his death. George H. Bowen's third or perhaps his fourth career was in astronomy. He was drafted into the navy in 1944, at the end of his first year as a student at Caltech, and ended his war-time service as an electronic technician on the aircraft carrier Shangri-La. He later said "In just nine months, starting from scratch (Ohm's law!), we learned an amazing amount - not by memorization, of course, but by study and real understanding of the basic function of the most advanced AC circuits then being used for instrumentation, measurements, communications, control systems, and much more." He gained a confidence that he could quickly and accurately diagnose and solve technical problems that stood him well in future work. One accomplishment he took particular pride in was figuring out how the radar control used cams and gears to solve the trigonometry for accurate pointing. He also described how the captain was alarmed when weather conditions changed so that refraction no longer showed them distant, small boats around the curvature of Earth. After the war, George Bowen returned to undergraduate and eventually graduate study at Caltech, where he was recruited to the biophysics research group headed by future Nobel Laureate Max Delbrück. George often described his joy in working with these first-rate scientists and finding himself accepted as a part of the effort. He finished his BS with honors in 1949 and his PhD in 1953 with a thesis on "Kinetic Studies on the Mechanism of Photoreactivation of Bacteriophase T2 Inactivated by Ultraviolet Light" involving work with E Coli. This work was supported by grants from the U
George Hoyt Whipple and the Impact of Liver on Anemia
dropdown arrow Site Map A-Z Index Menu Synopsis George Hoyt Whipple and the Impact of Liver on Anemia cases of anemia". George Hoyt Whipple Courtesy of University of Rochester Medical Center Whipple's main research was concerned with anemia and with the physiology and pathology of the liver. He won the
George Sand: últimas novelas, últimos ensueños...
Directory of Open Access Journals (Sweden)
Àngels Santa
2014-04-01
Full Text Available A propósito de la obra de George Sand, Œuvres complètes.Sous la direction de Béatrice Didier. 1870, I :Malgrétout. Édition critique par Dominique Laporte (París, Honoré Champion, 2013, 247 p. ISBN : 9782745322968 y de George Sand, Œuvres complètes.Sous la direction de Béatrice Didier. 1876 :La Tour de Percemont. Édition critique par Dominique Laporte (París, Honoré Champion, 2013, 247 p. ISBN : 9782745322951.
Structural remains at the early mediaeval fort at Raibania, Orissa
Sen, Bratati
2013-01-01
The fortifications of mediaeval India occupy an eminent position in the history of military architecture. The present paper deals with the preliminary study of the structural remains at the early mediaeval fort at Raibania in the district of Balasore in Orissa. The fort was built of stone very loosely kept together. The three-walled fortification interspersed by two consecutive moats, a feature evidenced at Raibania, w...
Generation of HEXA-deficient hiPSCs from fibroblasts of a Tay-Sachs disease patient.
Liu, Zhong; Zhao, Rui
2016-09-01
Human iPSC line TSD-01-hiPSC was generated from fibroblasts of a patient with infantile Tay-Sachs disease (TSD). The patient is compound heterozygous at the HEXA gene by carrying a 1278insTATC allele and an IVS12+1G>C allele. STEMCCA lentivirus, which expresses OCT4, SOX2, KLF4, and c-MYC from a polycistronic transcript, were used for reprogramming. TSD-01-hiPSC express pluripotency markers such as OCT4, SOX2, NANOG, Tra-1-60, and alkaline phosphatase, and can differentiate into tissues from all the three embryonic germ layers. This TSD patient-derived hiPSC line may serve as a valuable in vitro tool for disease modeling and drug test. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
Late-onset Tay-Sachs disease: the spectrum of peripheral neuropathy in 30 affected patients.
Shapiro, Barbara E; Logigian, Eric L; Kolodny, Edwin H; Pastores, Gregory M
2008-08-01
Late-onset Tay-Sachs (LOTS) disease is a chronic, progressive, lysosomal storage disorder caused by a partial deficiency of beta-hexosaminidase A (HEXA) activity. Deficient levels of HEXA result in the intracellular accumulation of GM2-ganglioside, resulting in toxicity to nerve cells. Clinical manifestations primarily involve the central nervous system (CNS) and lower motor neurons, and include ataxia, weakness, spasticity, dysarthria, dysphagia, dystonia, seizures, psychosis, mania, depression, and cognitive decline. The prevalence of peripheral nervous system (PNS) involvement in LOTS has not been well documented, but it has traditionally been thought to be very low. We examined a cohort of 30 patients with LOTS who underwent clinical and electrophysiologic examination, and found evidence of a predominantly axon loss polyneuropathy affecting distal nerve segments in the lower and upper extremities in eight patients (27%).
George Morrison: Anishinaabe Expressionist Artist
Vizenor, Gerald
2006-01-01
In this article, the author discusses the life and works of an Anishinaabe expressionist artist George Morrison. Morrison was an eminent expressionist painter with a singular romantic vision and an erudite sense of natural reason and liberty. He created an elusive shimmer of "endless space," the color and eternal motion of nature. The…
Black Swan Event Assessment for Fort Leonard Wood, Missouri
2016-03-01
ER D C/ CE RL S R- 16 -1 Net Zero Planning for Fort Leonard Wood Black Swan Event Assessment for Fort Leonard Wood, Missouri Co ns...search for other technical reports published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. Net Zero Planning for...1.8 degrees Celsius knots 0.5144444 meters per second miles (US statute) 1,609.347 meters miles per hour 0.44704 meters per second ERDC/CERL SR
2010-07-19
... To Release Airport Property at Fort Smith Regional Airport, Fort Smith, AR AGENCY: Federal Aviation... rule and invites public comment on the release of land at Fort Smith Regional Airport under the.... John Parker, Airport Director, Fort Smith Regional Airport, at the following address: Fort Smith...
The Georg Jensen and Alessi Design
DEFF Research Database (Denmark)
Tanderup, Sisse
2009-01-01
in the design process. Alessi's motivation for involving the concept of memory is that it adds a cultural dimension to the design objects, enabling the objects to make an identity-forming impact. Compared to this, Danish and Scandinavian design practice has traditionally focused on form and function...... The Georg Jensen and Alessi Design A comparative analysis focusing on the use of memory The dimension of memory has become a central theme within several fields of research, including architecture, philosophy, psychology and medicine. However, memory has not yet been explored more substantially...... as an independent identity category in design research. This article deals with the use of the memory theme in design examples from the two companies Georg Jensen and Alessi. Italian design practice is characterized by a tradition of involving memory categories from Italian history, philosophy, art and tradition...
Shapiro, Barbara E; Pastores, Gregory M; Gianutsos, John; Luzy, Cécile; Kolodny, Edwin H
2009-06-01
To evaluate the safety and efficacy of miglustat in patients with GM2 gangliosidosis. A randomized, multicenter, open-label, 12-month study involving patients aged 18 years or older, randomized 2:1 to miglustat (200 mg TID) or "no miglustat treatment." This study was followed by 24 months of extended treatment during which all patients received miglustat. Primary efficacy endpoints were change in eight measures of isometric muscle strength in the limbs and isometric grip strength, evaluated at baseline, and months 12 and 36. Secondary efficacy endpoints included gait, balance, disability, and other neurological assessments. Safety evaluations included adverse event reporting. Thirty patients (67% male, age range 18-56 years) with late-onset Tay-Sachs disease were enrolled; 20 were randomized to miglustat and 10 to "no miglustat treatment." Muscle and grip strength generally decreased over the study period. No differences were observed between the two groups in any efficacy measure, either during the 12-month randomized phase or the full 36 months. The most common treatment-related adverse events were decrease in weight and diarrhea. Miglustat treatment was not shown to lead to measurable benefits in this cohort of patients with late-onset Tay-Sachs disease. The observed safety profile was consistent with that of the approved dose (100 mg TID) in type 1 Gaucher disease.
Liquid radwaste processing history at Fort Calhoun Nuclear Station
International Nuclear Information System (INIS)
Bilau, A.; Rutar, F.
1989-01-01
This report presents a historical perspective of liquid radwaste processing at the Fort Calhoun Unit 1 Nuclear Power Station, located in east central Nebraska. Of particular interest is the textual and graphical comparison of the operational implications of the various waste processing methods employed in the last ten years at the Fort Calhoun Station. Fort Calhoun's waste collection and processing systems are described in detail. These process systems include evaporation and solidification employing an in-plant drum solidification system. This solidification system was later replaced with vendor solidification services which solidified wastes in large liners. Ultimately, the plant converted its processing operation to ion exchange cleanup using ion selective media. The operational and economic impact of each of these process systems is discussed including overall costs, personnel exposure, capital expenditure requirements, burial volumes generated, maintenance and reliability assessments. Operational goals and performance criteria employed in the decision-making process for selection of the optimal technology are discussed, including the impact of various influent and effluent requirements
Library Journal, 2005
2005-01-01
Many movers and shakers inspire admiration and even awe, but those who inspire love are the mentors who have changed lives. That is why many grateful librarians nominated Linda Golian-Lui and George Oberle. Both of them were accidental librarians, work-study students whose supervisors encouraged them to become paraprofessionals, and then…
Sundhedsprofessionelles begejstring for fortællinger fra levet erfaring
DEFF Research Database (Denmark)
Liveng, Anne; Larsen, Christine; Lange, Mads
2018-01-01
I 2013 etablerede psykiatrien i Region Hovedstaden, Danmark, et undervisningsprogram om recovery for sundhedsprofessionelle. Evalueringer af programmet viste et udtalt engagement i fortællingen fra underviseren med levet erfaring. Artiklen diskuterer hvordan dette kan forstås. Evalueringsmaterialet...... analyseres ud fra et læringsteoretisk perspektiv og fokuserer på: 1) Betydningen af fortællingens emotionelle indhold, 2) Rolle-bytningen mellem personen med levet erfaring og sundhedsprofessionelle, og 3) Workshoppene som et læringsrum, der aktiverer refleksioner over strukturer og organisering af...
Fort Saint Vrain operational experience
International Nuclear Information System (INIS)
Fuller, C.H.
1989-01-01
Fort St. Vrain (FSV), on the system of the Public Service Company of Colorado, is the only high temperature gas-cooled (HTGR) power reactor in the United States. The plant features a helium-cooled reactor with a uranium-thorium fuel cycle. The paper describes the experience made during its operation. (author). 2 refs, 4 figs, 2 tabs
DEFF Research Database (Denmark)
Jørgensen, Kenneth Mølbjerg
2008-01-01
Ledelse er et af nøgleordene i fornyelsen af den offentlige sektor. Vi har imidlertid glemt et væsentligt aspekt af ledelse. Dette skyldes ikke mindst, at omgangsformen i dag er reguleret af information, mens den tidligere var reguleret af fortælleevnen. Evnen til dialog, indlevelse og nærvær er...
Kdo byl Georg Placzek (1905-1955)
Czech Academy of Sciences Publication Activity Database
Gottvald, Aleš
2005-01-01
Roč. 55, č. 3 (2005), s. 275-287 ISSN 0009-0700 Institutional research plan: CEZ:AV0Z20650511 Keywords : Georg Placzek * the oretical physics * history of physics * nuclear physics * Manhattan project * spectroscopy Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders
Rumlige fortællinger fra mobilt og web-baseret GIS
DEFF Research Database (Denmark)
Møller-Jensen, Lasse
2009-01-01
Denne artikel handler om begrebet rumlige fortællinger med anvendelse af fortællingshenvisninger, og disses potentielle rolle ved implementation af fleksible og tematiske turistinformationssystemer. Artiklen fokuserer på brugen af mobile, positionsbekendte enheder, såsom visse PDA'er og smartphon......, samt på web-gis. Der præsenteres to anvendelseseksempler: et fra det centrale København og et fra et område nær Accra, Ghana....
Haldusreformist üldiselt / Georg Sootla, Kersten Kattai
Sootla, Georg, 1954-
2016-01-01
Haldusreformi ning Pärnu linna ja Are, Audru, Paikuse ja Tõstamaa valla ühinemise kohta jagavad selgitusi ühinemise konsultandid, Tallinna Ülikooli professor Georg Sootla ja lektor Kersten Kattai
Moessbauer Study of Sedimentary Rocks from King George Island, Antarctica
International Nuclear Information System (INIS)
Kuzmann, E.; Souza, P. A. de; Schuch, L. A.; Oliveira, A. C. de; Garg, R.; Garg, V. K.
2002-01-01
The separation of continents at the periphery of Antarctica occurred about 180 ma ago due to volcanic activity. Geological faults can be very important in the study of geological occurrences. Such geological faults occur across the Admiralty Bay, King George Island, and have been studied in detail previously. Controversial statements were given in earlier works, based on conventional geological investigations, as to whether altered 'Jurassic' and unaltered Tertiary rocks were separated by a major fault which goes across the Admiralty Bay, or whether there is no difference in the alteration of the rocks located at either side of the fault. The aim of our work is to investigate rock samples from the Admiralty Bay of King George Island, Antarctica, from different locations on both sides of the geological fault. For these investigations 57 Fe Moessbauer spectroscopy and X-ray diffractometry were used. We have found that the phase composition, and the iron distribution among the crystallographic sites of iron-bearing minerals, are characteristic of the location of the rock samples from the Admiralty Bay of King George Island. There is a much higher amount of iron oxides in the rocks from the south part of the geological fault than in the north part. The differences in the mineral composition and iron distribution showed that the rocks in the southern part of the geological fault of King George Island are significantly altered compared to the rocks in the northern part. Our present results support and complement well the results obtained earlier on soils from King George Island.
Fort Mason Center: Pier 2 Project
Energy Technology Data Exchange (ETDEWEB)
Nester, Patrick [Fort Mason Center, San Francisco, CA (United States)
2014-08-30
The rooftop Photovoltaic (PV) panels and radiant piping project was constructed by Fort Mason Center as part of its $21 million comprehensive rehabilitation of the Pier 2 shed which include the shed’s electrical, natural gas and water systems. Fort Mason Center improved performance while reducing energy and water usage and costs to demonstrate the efficiencies and opportunities available to large multi-function facilities. The scalable demand of these facilities required a layered approach to conservation, control and production. The project employed a comprehensive retrofit of electrical natural gas, and plumbing systems to maximize efficiency and lower carbon footprint specifically to demonstrate the effectiveness of these strategies in a public setting with varied and diverse use. The project was completed in July 2014 and met the expected outcomes regarding increased comfort and operational efficiency throughout the Pier 2 shed as well as on site electrical generation of current consumption. The entire Pier 2 shed project won a 2015 California Preservation Foundation design award for historic rehabilitation.
Analyzing Street Art to Present the Heritage of George Town, Malaysia
Directory of Open Access Journals (Sweden)
Seyedehelham Sadatiseyedmahalleh
2015-08-01
Full Text Available Street art comprises all kinds of art developed in public locations. This form of art has spread to all heritage streets in George Town, the capital of Penang Island, which is also a known UNESCO World Heritage Site. However, instead of its heritage, food, and interesting past life and structure, the rapid multiplication of street art in George Town has created a new and unusual art that attracts tourists. Street art has spread to small roads and heritage streets in the city. This art increases the awareness of spectators by introducing them to the rich history of these streets and inducing a lively concept in the inner city of George Town. Accordingly, the impact of iron rod sculptures and murals, which comprises approximately 90% of street art in George Town, were determined to explore and identify the effects of this street art on this world heritage site. The findings were obtained from 263 out of 306 questionnaires accomplished by tourists in George Town. The results confirm that tourists prefer murals over iron rod sculptures. Iron rod sculptures are designed to tell the history of the street, whereas murals are designed to create aesthetic value. The findings indicated that similar to iron rod sculptures, more control should be exercised on the subjects of murals.
BRAND EQUITY OF LAHORE FORT AS A TOURISM DESTINATION BRAND
KASHIF, MUHAMMAD; SAMSI, SITI ZAKIAH MELATU; SARIFUDDIN, SYAMSULANG
2015-01-01
ABSTRACTStudies that measure the brand equity of destination brands by using the Customer-Based Brand Equity (CBBE) model in a developing country context are scarce. The present study investigates the destination brand equity of the Lahore Fort by employing the CBBE model in a developing country context of Pakistan. Following the positivist tradition, we adopted a survey-based approach to collect data from 237 tourists visiting the Lahore Fort. Data were collected through a questionnaire deve...
Simultaneous preimplantation genetic diagnosis for Tay-Sachs and Gaucher disease.
Altarescu, Gheona; Brooks, Barry; Margalioth, Ehud; Eldar Geva, Talia; Levy-Lahad, Ephrat; Renbaum, Paul
2007-07-01
Preimplantation genetic diagnosis (PGD) for single gene defects is described for a family in which each parent is a carrier of both Tay-Sachs (TS) and Gaucher disease (GD). A multiplex fluorescent polymerase chain reaction protocol was developed that simultaneously amplified all four familial mutations and 10 informative microsatellite markers. In one PGD cycle, seven blastomeres were analysed, reaching a conclusive diagnosis in six out of seven embryos for TS and in five out of seven embryos for GD. Of the six diagnosed embryos, one was wild type for both TS and GD, and three were wild type for GD and carriers of TS. Two remaining embryos were compound heterozygotes for TS. Two transferable embryos developed into blastocysts (wt/wt and wt GD/carrier TS) and both were transferred on day 5. This single cycle of PGD resulted in a healthy live child. Allele drop-out (ADO) was observed in three of 34 reactions, yielding an 8% ADO rate. The occurrence of ADO in single cell analysis and undetected recombination events are primary causes of misdiagnosis in PGD and emphasize the need to use multiple polymorphic markers. So far as is known, this is the first report of concomitant PGD for two frequent Ashkenazi Jewish recessive disorders.
Comprehensive Inventory and Determinations of Eligibility for Fort Riley Buildings: 1857-1963
2009-09-01
become fashionable . Stone residences built at Fort Riley after the 1850s all have rock-faced walls and most have contrasting smooth-faced lintels...507 is significant as a wood-framed Folk Victorian cottage. While Building 507 is one of four Folk Victorian buildings at Fort Riley, it possesses a
Directory of Open Access Journals (Sweden)
Marta de Toledo Benassi
2006-07-01
Full Text Available Fresh-cut broccoli florets were packed in polypropylene pots containing a sachet with 1- methylcyclopropene (1-MCP and sealed with biodegradable starch-based film. Broccoli was stored for 8 days at 12oC and after this time the color and the texture of the product were similar of the fresh broccoli, with no off-flavor development or decay. Active packaging with 1-MCP in a sachet was efficient to extent shelf life of broccoli florets retarding yellowing and vitamin C losses. It is an alternative of 1-MCP treatment for fresh-cut products and besides, the sachet can absorbs condensed water reducing spoilage and off-odor development.Brócolis minimamente processados foram embalados em bandejas de polipropileno com sachê contendo 1-metilciclopropeno (1-MCP e selado com filme biodegradável de amido. Os brócolis foram armazenados por 8 dias a 12oC e após este tempo a cor e a textura mantiveram-se similares às do produto fresco, sem desenvolvimento de odor não característico ou podridão. A embalagem ativa contendo 1-MCP na forma de sachê foi eficiente no aumento da vida de prateleira de brócolis, retardando o amarelecimento e a perda de vitamina C. Esta é uma alternativa para o tratamento com 1-MCP para produtos minimamente processados e além disso, o sachê pode absorver a água condensada, reduzindo a deterioração e o desenvolvimento de odor não característico.
International Nuclear Information System (INIS)
Taghavi-Chabert, Arman
2011-01-01
Optical (or Robinson) structures are one generalization of four-dimensional shearfree congruences of null geodesics to higher dimensions. They are Lorentzian analogues of complex and CR structures. In this context, we extend the Goldberg-Sachs theorem to five dimensions. To be precise, we find a new algebraic condition on the Weyl tensor, which generalizes the Petrov type II condition, in the sense that it ensures the existence of such congruences on a five-dimensional spacetime, vacuum or under weaker assumptions on the Ricci tensor. This results in a significant simplification of the field equations. We discuss possible degenerate cases, including a five-dimensional generalization of the Petrov type D condition. We also show that the vacuum black ring solution is endowed with optical structures, yet fails to be algebraically special with respect to them. We finally explain the generalization of these ideas to higher dimensions, which has been checked in six and seven dimensions.
The geology and mechanics of formation of the Fort Rock Dome, Yavapai County, Arizona
Fuis, Gary S.
1996-01-01
The Fort Rock Dome, a craterlike structure in northern Arizona, is the erosional product of a circular domal uplift associated with a Precambrian shear zone exposed within the crater and with Tertiary volcanism. A section of Precambrian to Quaternary rocks is described, and two Tertiary units, the Crater Pasture Formation and the Fort Rock Creek Rhyodacite, are named. A mathematical model of the doming process is developed that is consistent with the history of the Fort Rock Dome.
Integrated Sachs-Wolfe effect versus redshift test for the cosmological parameters
Kantowski, R.; Chen, B.; Dai, X.
2015-04-01
We describe a method using the integrated Sachs-Wolfe (ISW) effect caused by individual inhomogeneities to determine the cosmological parameters H0, Ωm , and ΩΛ, etc. This ISW-redshift test requires detailed knowledge of the internal kinematics of a set of individual density perturbations, e.g., galaxy clusters and/or cosmic voids, in particular their density and velocity profiles, and their mass accretion rates. It assumes the density perturbations are isolated and embedded (equivalently compensated) and makes use of the newly found relation between the ISW temperature perturbation of the cosmic microwave background (CMB) and the Fermat potential of the lens. Given measurements of the amplitudes of the temperature variations in the CMB caused by such clusters or voids at various redshifts and estimates of their angular sizes or masses, one can constrain the cosmological parameters. More realistically, the converse is more likely, i.e., if the background cosmology is sufficiently constrained, measurement of ISW profiles of clusters and voids (e.g., hot and cold spots and rings) can constrain dynamical properties of the dark matter, including accretion, associated with such lenses and thus constrain the evolution of these objects with redshift.
Georges et les secrets de l'univers
Hawking, Lucy; Galfard, Christophe; Parsons, Gary
2011-01-01
Un voyage ex-tra-or-di-naire dans l'Univers! Le jour où Georges rencontre ses nouveaux voisins, il est loin d'imaginer que sa vision du monde va être totalement bouleversée. Chez la jeune Annie et Éric, son scientifique de père, le garçon découvre Cosmos, l'ordinateur le plus perfectionné qui soit. Sa super intelligence permet de protéger Georges et ses amis aux quatre coins de l'Univers ! Hélas, quelqu'un nourrit de sombres projets... et quand on sait qu'il n y a rien de plus dangereux dans l'espace qu'un trou noir, il y a du souci à se faire ! Un roman essentiel sur l'Univers avec les découvertes de Stephen Hawking.
Ecological Baseline, Fort Hood, Texas
1980-08-01
cedar eTm (Uiimus crassifolia), Texas ash (Fraxinus texansis), and Texas persimmon ( Diospyros texana). Conversely, the two predominant tree species...Ilex decidua), Mex- ican buckeye (Ungnadia spjeciosa), and Texas persimmon ( Diospyros texana). Vines included greenbrier (Smilax bona-nox) and white...Hedgehey Cactus (Echinocereus sp.) has been observed on Fort Hood. Due to the brief period of flowering for this genus , the individual species were not
Fort Davis National Historic Site : acoustical monitoring
2013-06-01
During the summer of 2010 (September - October 2010), the Volpe Center collected baseline acoustical data at Fort Davis National Historic Site (FODA)at two sites deployed for approximately 30 days each. The baseline data collected during this period ...
George W. Bushi "intellektuaalne armuromaan" / Urmas Kiil
Kiil, Urmas
2005-01-01
Paljude poliitikute arvates kinnitab USA presidendi George Bushi vaimustus Natan Sharanski raamatust "The Case of Democracy: The Power of Freedom to Overcome Tyranny and Terror " fakti, et midagi pole tema poliitikas muutunud ka teisel ametiajal
Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease.
Seyrantepe, Volkan; Demir, Secil Akyildiz; Timur, Zehra Kevser; Von Gerichten, Johanna; Marsching, Christian; Erdemli, Esra; Oztas, Emin; Takahashi, Kohta; Yamaguchi, Kazunori; Ates, Nurselin; Dönmez Demir, Buket; Dalkara, Turgay; Erich, Katrin; Hopf, Carsten; Sandhoff, Roger; Miyagi, Taeko
2018-01-01
Tay-Sachs disease is a severe lysosomal storage disorder caused by mutations in Hexa, the gene that encodes for the α subunit of lysosomal β-hexosaminidase A (HEXA), which converts GM2 to GM3 ganglioside. Unexpectedly, Hexa -/- mice have a normal lifespan and show no obvious neurological impairment until at least one year of age. These mice catabolize stored GM2 ganglioside using sialidase(s) to remove sialic acid and form the glycolipid GA2, which is further processed by β-hexosaminidase B. Therefore, the presence of the sialidase (s) allows the consequences of the Hexa defect to be bypassed. To determine if the sialidase NEU3 contributes to GM2 ganglioside degradation, we generated a mouse model with combined deficiencies of HEXA and NEU3. The Hexa -/- Neu3 -/- mice were healthy at birth, but died at 1.5 to 4.5months of age. Thin-layer chromatography and mass spectrometric analysis of the brains of Hexa -/- Neu3 -/- mice revealed the abnormal accumulation of GM2 ganglioside. Histological and immunohistochemical analysis demonstrated cytoplasmic vacuolation in the neurons. Electron microscopic examination of the brain, kidneys and testes revealed pleomorphic inclusions of many small vesicles and complex lamellar structures. The Hexa -/- Neu3 -/- mice exhibited progressive neurodegeneration with neuronal loss, Purkinje cell depletion, and astrogliosis. Slow movement, ataxia, and tremors were the prominent neurological abnormalities observed in these mice. Furthermore, radiographs revealed abnormalities in the skeletal bones of the Hexa -/- Neu3 -/- mice. Thus, the Hexa -/- Neu3 -/- mice mimic the neuropathological and clinical abnormalities of the classical early-onset Tay-Sachs patients, and provide a suitable model for the future pre-clinical testing of potential treatments for this condition. Copyright © 2017 Elsevier Inc. All rights reserved.
DEFF Research Database (Denmark)
Willert, Søren
2016-01-01
Teksten er bygget op som følger: Jeg starter med fortællingen om hhv systemperspektivets, herunder socialkonstruktionismens, og kompleksitetsperspektivets historiske tilblivelse. Begge disse fortællinger rundes af med en fremstilling af de etiske grundlagsbetragtninger, som – i al deres forskelli...... samfundsfilosof og socialpsykolog George Herbert Mead (1863-1934) leverer vigtig teoretisk baggrundsinspiration til disse afsluttende brobygningsovervejelser....
Electricity Generation from Geothermal Resources on the Fort Peck Reservation in Northeast Montana
Energy Technology Data Exchange (ETDEWEB)
Carlson, Garry J. [Gradient Geophysics Inc., Missoula, MT (United States); Birkby, Jeff [Birkby Consulting LLC, Missoula, MT (United States)
2015-05-12
Tribal lands owned by Assiniboine and Sioux Tribes on the Fort Peck Indian Reservation, located in Northeastern Montana, overlie large volumes of deep, hot, saline water. Our study area included all the Fort Peck Reservation occupying roughly 1,456 sq miles. The geothermal water present in the Fort Peck Reservation is located in the western part of the Williston Basin in the Madison Group complex ranging in depths of 5500 to 7500 feet. Although no surface hot springs exist on the Reservation, water temperatures within oil wells that intercept these geothermal resources in the Madison Formation range from 150 to 278 degrees F.
International Nuclear Information System (INIS)
Little, M P
2004-01-01
Bystander effects following exposure to α-particles have been observed in many experimental systems, and imply that linearly extrapolating low dose risks from high dose data might materially underestimate risk. Brenner and Sachs (2002 Int. J. Radiat. Biol. 78 593-604; 2003 Health Phys. 85 103-8) have recently proposed a model of the bystander effect which they use to explain the inverse dose rate effect observed for lung cancer in underground miners exposed to radon daughters. In this paper we fit the model of the bystander effect proposed by Brenner and Sachs to 11 cohorts of underground miners, taking account of the covariance structure of the data and the period of latency between the development of the first pre-malignant cell and clinically overt cancer. We also fitted a simple linear relative risk model, with adjustment for age at exposure and attained age. The methods that we use for fitting both models are different from those used by Brenner and Sachs, in particular taking account of the covariance structure, which they did not, and omitting certain unjustifiable adjustments to the miner data. The fit of the original model of Brenner and Sachs (with 0 y period of latency) is generally poor, although it is much improved by assuming a 5 or 6 y period of latency from the first appearance of a pre-malignant cell to cancer. The fit of this latter model is equivalent to that of a linear relative risk model with adjustment for age at exposure and attained age. In particular, both models are capable of describing the observed inverse dose rate effect in this data set
Technical evaluation report of the Fort St. Vrain final draft upgraded technical specifications
International Nuclear Information System (INIS)
Kimura, C.Y.
1989-01-01
This report is a technical evaluation of the final draft of the Fort St. Vrain (FSV) Upgraded Technical Specifications (UT/S) as issued by Public Service of Colorado (PSC) on May 27, 1988 with subsequent supplemental updates issued on June 15, 1988 and August 5, 1988. It has been compared for consistency, and safety conservatism with the Fort St. Vrain (FSV) Updated Final Safety Analysis Report (FSAR), the FSV Safety Evaluation Report (SER), the Facility Operating License, DPR-34, and all amendments to the Facility Operating License issued as of June 1, 1988, and Appendix A to the Operating License DPR-34, Technical Specifications. Because of the age of the plant, no supplements to the Fort St. Vrain SER have been issued since the original SER was not issued as a WASH or a NUREG report. This made it necessary to review all amendments to the Facility Operating License since they would contain the safety evaluations done to support changes to the Facility Operating License. The upgraded Fort St. Vrain Technical Specifications were also broadly compared with the latest Westinghouse Standard Technical Specifications (WSTS) to assure that what was proposed for Fort St. Vrain was consistent with the latest NRC staff practices for standard technical specifications
Energy Technology Data Exchange (ETDEWEB)
Rogier, E.
2000-10-01
This article is a short biography of the French man Georges Darrieus (1888-1979) who invented the vertical wind turbine. G.Darrieus can be considered as the first industrial researcher in France, he was a double authority in sciences and in industry machinery. He presented more than 50 patterns and wrote about 700 scientific and technological articles.
Energy Technology Data Exchange (ETDEWEB)
Hou, Y.; Vavougios, G.; Hinek, A. [Univ. of Toronto (Canada)] [and others
1996-07-01
Substitution mutations adversely affecting the {alpha}-subunit of {beta}-hexosaminidase A ({alpha}{beta}) (EC 3.2.1.52) result in Tay-Sachs disease. The majority affect the initial folding of the pro-{alpha} chain in the endoplasmic reticulum, resulting in its retention and degradation. A much less common occurrence is a mutation that specifically affects an {open_quotes}active-site{close_quotes} residue necessary for substrate binding and/or catalysis. In this case, hexosaminidase A is present in the lysosome, but it lacks all {alpha}-specific activity. This biochemical phenotype is referred to as the {open_quotes}B1-variant form{close_quotes} of Tay-Sachs disease. Kinetic analysis of suspected B1-variant mutations is complex because hexosaminidase A is heterodimeric and both subunits possess similar active sites. In this report, we examine a previously identified B1-variant mutation, {alpha}-Val{sup 192}Leu. Chinese hamster ovary cells were permanently cotransfected with an {alpha}-cDNA-construct encoding the substitution and a mutant {beta}-cDNA ({beta}-Arg{sup 211}Lys), encoding a {beta}-subunit that is inactive but normal in all other respects. We were surprised to find that the Val{sup 192}Leu substitution produced a pro-{alpha} chain that did not form {alpha}-{beta} dimers and was not transported to the lysosome. Finally, we reexamined the hexosaminidase activity and protein levels in the fibroblasts from the original patient. These data were also not consistent with the biochemical phenotype of the B1 variant of Tay-Sachs disease previously reported to be present. Thus, we conclude that the Val{sup 192}Leu substitution does not specifically affect the {alpha}-active site. 23 refs., 4 figs., 2 tabs.
DEFF Research Database (Denmark)
Krøjer, Jo; Hutters, Camilla
2009-01-01
Unges valg af videregående uddannelse er omgærdet af forventninger. Forventninger til hvad man skal vælge. Forventninger til hvor lang tid, man skal være om at tage en uddannelse. Og forventninger til, hvad uddannelsen skal føre til. Artiklen præsenterer fortælleværkstedet, en metode til kollekti...... refleksioner over egne og adres forventninger til og tanker om uddannelsesvalg....
2012-09-20
...-Fort Rock Ranger District; Oregon; Withdrawal of Notice for Preparation of an Environmental Impact... Administration, USDOT. ACTION: Notice of withdrawal. SUMMARY: The Bend-Fort Rock Ranger District and FHWA are..., Project Leader, Bend- Fort Rock Ranger District, 63095 Deschutes Market Road, Bend, OR 97701, phone 541...
Georg Cantor: habitar lo eterno
Directory of Open Access Journals (Sweden)
Juan Manuel Rodríguez Penagos
Full Text Available Este artículo pone en discusión la relación entre estructura psíquica y la producción lógica del delirio; para ello, parte de un matemático alemán llamado Georg Cantor. Aquí se discute la relación entre la producción matemática y la instalación de su psicosis.
Noonan's and DiGeorge syndromes with monosomy 22q11.
Wilson, D I; Britton, S B; McKeown, C; Kelly, D; Cross, I E; Strobel, S; Scambler, P J
1993-01-01
A boy with the dysmorphic features of Noonan's syndrome and pulmonary valve stenosis who had evidence of hypoparathyroidism and abnormal T lymphocyte numbers in the neonatal period is reported. He had a normal karyotype but molecular analysis revealed a submicroscopic deletion within chromosome 22q11, the region deleted in DiGeorge syndrome. Thus this child has both Noonan's syndrome and DiGeorge syndrome; 22q11 is a candidate region for a gene defective in Noonan's syndrome.
U.S. GLOBEC Georges Bank Long-Term Moored Program. Part 1. Mooring Configuration
National Research Council Canada - National Science Library
Irish, J. D; Kerry, S; Fucile, P; Beardsley, R. C; Lord, J; Brink, K. H
2005-01-01
As part of the U.S. GLOBEC Northwest Atlantic/Georges Bank program, moorings were deployed on Georges Bank as part of the broad-scale survey component to help measure the temporal variability of both physical...
Cannon Fire Soon to Accompany Bugle Call at Fort Detrick | Poster
Beginning June 14, the familiar bugle calls at Fort Detrick will be joined by a special percussion instrument: a cannon. A single cannon shot will be fired on the first note of “Reveille,” which signals the start of each day and is accompanied by the raising of the American flag. “Reveille” sounds at 6:30 a.m. At 5 p.m., Fort Detrick plays “Retreat,” which alerts the post that
Site-Based Budgeting in Fort Worth, Texas.
Peternick, Lauri; Sherman, Joel
1998-01-01
Examines the Fort Worth Independent School District's decentralized decision-making system through three lenses: a review of site-based decision-making procedures at several schools; an examination of who participates; and stakeholders' perceptions. Some schools operated democratically, significantly including teachers, parents, and community…
Hagelstein, Maud
2012-01-01
Georges Didi-Huberman est un philosophe et un historien de l'art français né à Saint-Étienne le 13 juin 1953. Il a été pensionnaire à l'Académie de France à Rome (Villa Médicis) et résident à la Fondation Berenson de la Villa I Tatti à Florence. Il enseigne à l’École des hautes études en sciences sociales où il est maître de conférences depuis 1990. Bibliographie Invention de l’hystérie. Charcot et l’Iconographie photographique de la Salpêtrière, sur l'École de la Salpêtrière, Macula, 1982. M...
Construction experience on PCRV liners at Fort St. Vrain
International Nuclear Information System (INIS)
Cliff, J.O.; Wunderlich, R.G.
1976-01-01
The construction of the steel liners for the Fort St. Vrain prestressed concrete reactor vessel presented many unique problems for which techniques were developed to satisfy the rigid specification requirements. The PCRV cavity liner was fabricated from 1.9cm carbon steel plate. The liners were partially fabricated by Pittsburgh-Des Moines Steel Company at their Pittsburgh manufacturing facility. The liners were then shipped by rail to within approximately five miles of the jobsite and then trucked the remaining distance. The construction techniques, dimensional control, concrete support and testing utilized on the Fort St. Vrain project are presented in detail and demonstrate the flexibility of the PCRV for field construction. (author)
George Bush peab sõjalist jõudu viimaseks valikuks / George W. Bush ; interv. Kaarel Kaas
Bush, George W., 1946-
2005-01-01
Ilmunud ka: Põhjarannik 7. mai 2005, lk. 2, Severnoje Poberezhje 7. mai, 2005, lk. 2. USA president George Bush andis 5. mail Valges Majas intervjuu kuuele Euroopa ajakirjanikule. 9. mai pidustustest Moskvas, USA-Läti, Venemaa-Balti riikide suhetest, demokraatiast Venemaal, Ameerika Ühendriikide ning Baltimaade viisarežiimist, vabaduse mõistestst, kinnipeetavate kohtlemisest Guantanamo sõjaväebaasis, relvade kasutamise vajadusest, terrorismist. Vt. samas: Kuidas usutlus võimalikuks sai
Directory of Open Access Journals (Sweden)
Mehul Mistri
Full Text Available Tay Sachs disease (TSD is a neurodegenerative disorder due to β-hexosaminidase A deficiency caused by mutations in the HEXA gene. The mutations leading to Tay Sachs disease in India are yet unknown. We aimed to determine mutations leading to TSD in India by complete sequencing of the HEXA gene. The clinical inclusion criteria included neuroregression, seizures, exaggerated startle reflex, macrocephaly, cherry red spot on fundus examination and spasticity. Neuroimaging criteria included thalamic hyperdensities on CT scan/T1W images of MRI of the brain. Biochemical criteria included deficiency of hexosaminidase A (less than 2% of total hexosaminidase activity for infantile patients. Total leukocyte hexosaminidase activity was assayed by 4-methylumbelliferyl-N-acetyl-β-D-glucosamine lysis and hexosaminidase A activity was assayed by heat inactivation method and 4-methylumbelliferyl-N-acetyl-β-D-glucosamine-6-sulphate lysis method. The exons and exon-intron boundaries of the HEXA gene were bidirectionally sequenced using an automated sequencer. Mutations were confirmed in parents and looked up in public databases. In silico analysis for mutations was carried out using SIFT, Polyphen2, MutationT@ster and Accelrys Discovery Studio softwares. Fifteen families were included in the study. We identified six novel missense mutations, c.340 G>A (p.E114K, c.964 G>A (p.D322N, c.964 G>T (p.D322Y, c.1178C>G (p.R393P and c.1385A>T (p.E462V, c.1432 G>A (p.G478R and two previously reported mutations. c.1277_1278insTATC and c.508C>T (p.R170W. The mutation p.E462V was found in six unrelated families from Gujarat indicating a founder effect. A previously known splice site mutation c.805+1 G>C and another intronic mutation c.672+30 T>G of unknown significance were also identified. Mutations could not be identified in one family. We conclude that TSD patients from Gujarat should be screened for the common mutation p.E462V.
Mistri, Mehul; Tamhankar, Parag M; Sheth, Frenny; Sanghavi, Daksha; Kondurkar, Pratima; Patil, Swapnil; Idicula-Thomas, Susan; Gupta, Sarita; Sheth, Jayesh
2012-01-01
Tay Sachs disease (TSD) is a neurodegenerative disorder due to β-hexosaminidase A deficiency caused by mutations in the HEXA gene. The mutations leading to Tay Sachs disease in India are yet unknown. We aimed to determine mutations leading to TSD in India by complete sequencing of the HEXA gene. The clinical inclusion criteria included neuroregression, seizures, exaggerated startle reflex, macrocephaly, cherry red spot on fundus examination and spasticity. Neuroimaging criteria included thalamic hyperdensities on CT scan/T1W images of MRI of the brain. Biochemical criteria included deficiency of hexosaminidase A (less than 2% of total hexosaminidase activity for infantile patients). Total leukocyte hexosaminidase activity was assayed by 4-methylumbelliferyl-N-acetyl-β-D-glucosamine lysis and hexosaminidase A activity was assayed by heat inactivation method and 4-methylumbelliferyl-N-acetyl-β-D-glucosamine-6-sulphate lysis method. The exons and exon-intron boundaries of the HEXA gene were bidirectionally sequenced using an automated sequencer. Mutations were confirmed in parents and looked up in public databases. In silico analysis for mutations was carried out using SIFT, Polyphen2, MutationT@ster and Accelrys Discovery Studio softwares. Fifteen families were included in the study. We identified six novel missense mutations, c.340 G>A (p.E114K), c.964 G>A (p.D322N), c.964 G>T (p.D322Y), c.1178C>G (p.R393P) and c.1385A>T (p.E462V), c.1432 G>A (p.G478R) and two previously reported mutations. c.1277_1278insTATC and c.508C>T (p.R170W). The mutation p.E462V was found in six unrelated families from Gujarat indicating a founder effect. A previously known splice site mutation c.805+1 G>C and another intronic mutation c.672+30 T>G of unknown significance were also identified. Mutations could not be identified in one family. We conclude that TSD patients from Gujarat should be screened for the common mutation p.E462V.
Spontaneous appearance of Tay-Sachs disease in an animal model.
Zeng, B J; Torres, P A; Viner, T C; Wang, Z H; Raghavan, S S; Alroy, J; Pastores, G M; Kolodny, E H
2008-01-01
Tay-Sachs disease (TSD) is a progressive neurodegenerative disorder due to an autosomal recessively inherited deficiency of beta-hexosaminidase A (Hex A). Deficiency of Hex A in TSD is caused by a defect of the alpha-subunit resulting from mutations of the HEXA gene. To date, there is no effective treatment for TSD. Animal models of genetic diseases, similar to those known to exist in humans, are valuable and essential research tools for the study of potentially effective therapies. However, there is no ideal animal model of TSD available for use in therapeutic trials. In the present study, we report an animal model (American flamingo; Phoenicopterus ruber) of TSD with Hex A deficiency occurring spontaneously in nature, with accumulation of G(M2)-ganglioside, deficiency of Hex A enzymatic activity, and a homozygous P469L mutation in exon 12 of the hexa gene. In addition, we have isolated the full-length cDNA sequence of the flamingo, which consists of 1581 nucleotides encoding a protein of 527 amino acids. Its coding sequence indicates approximately 71% identity at the nucleotide level and about 72.5% identity at the amino acid level with the encoding region of the human HEXA gene. This animal model, with many of the same features as TSD in humans, could represent a valuable resource for investigating therapy of TSD.
2012-02-21
... Environmental Impact Statement for Extension of F-Line Streetcar Service to Fort Mason Center, San Francisco, CA... Environmental Impact Statement for the Extension of F-Line Streetcar Service to Fort Mason Center, San Francisco... the extension of the historic streetcar F-line from Fisherman's Wharf to the Fort Mason Center, in San...
Thymus transplantation for complete DiGeorge syndrome
DEFF Research Database (Denmark)
Davies, E Graham; Cheung, Melissa; Gilmour, Kimberly
2017-01-01
BACKGROUND: Thymus transplantation is a promising strategy for the treatment of athymic complete DiGeorge syndrome (cDGS). METHODS: Twelve patients with cDGS underwent transplantation with allogeneic cultured thymus. OBJECTIVE: We sought to confirm and extend the results previously obtained in a ...
BRAND EQUITY OF LAHORE FORT AS A TOURISM DESTINATION BRAND
Directory of Open Access Journals (Sweden)
Muhammad Kashif
2015-06-01
Full Text Available Studies that measure the brand equity of destination brands by using the Customer-Based Brand Equity (CBBE model in a developing country context are scarce. The present study investigates the destination brand equity of the Lahore Fort by employing the CBBE model in a developing country context of Pakistan. Following the positivist tradition, we adopted a survey-based approach to collect data from 237 tourists visiting the Lahore Fort. Data were collected through a questionnaire developed to explain the relationship of brand awareness, brand image, brand association, and brand loyalty with Lahore Fort’s overall brand equity. We used various robust statistical techniques such as correlation, regression and confirmatory factor analysis (using PLS method to reach meaningful conclusions and found that brand image and brand associations positively contribute to brand loyalty. Furthermore, brand loyalty significantly contributes towards overall brand equity. Pragmatically, this study measures the customer based brand equity of the Lahore Fort, a destination brand. The results are useful as they suggest a few strategies that can help policy makers to enhance Lahore Fort’s brand performance.
National Training Center Fort Irwin expansion area aquatic resources survey
Energy Technology Data Exchange (ETDEWEB)
Cushing, C.E.; Mueller, R.P.
1996-02-01
Biologists from Pacific Northwest National Laboratory (PNNL) were requested by personnel from Fort Irwin to conduct a biological reconnaissance of the Avawatz Mountains northeast of Fort Irwin, an area for proposed expansion of the Fort. Surveys of vegetation, small mammals, birds, reptiles, amphibians, and aquatic resources were conducted during 1995 to characterize the populations and habitats present with emphasis on determining the presence of any species of special concern. This report presents a description of the sites sampled, a list of the organisms found and identified, and a discussion of relative abundance. Taxonomic identifications were done to the lowest level possible commensurate with determining the status of the taxa relative to its possible listing as a threatened, endangered, or candidate species. Consultation with taxonomic experts was undertaken for the Coleoptera ahd Hemiptera. In addition to listing the macroinvertebrates found, the authors also present a discussion related to the possible presence of any threatened or endangered species or species of concern found in Sheep Creek Springs, Tin Cabin Springs, and the Amargosa River.
Ueki, Koichiro; Hashiba, Yukari; Marukawa, Kohei; Yoshida, Kan; Shimizu, Chika; Nakagawa, Kiyomasa; Yamamoto, Etsuhide
2007-07-01
To compare postoperative maxillary stability following Le Fort I osteotomy for the correction of occlusal cant as compared with conventional Le Fort I osteotomy for maxillary advancement. The subjects were 40 Japanese adults with jaw deformities. Of these, 20 underwent a Le Fort I osteotomy and intraoral vertical ramus osteotomy (IVRO) to correct asymmetric skeletal morphology and inclined occlusal cant. The other 20 patients underwent a Le Fort I osteotomy and sagittal split ramus osteotomy (SSRO) to advance the maxilla. Lateral and posteroanterior cephalograms were taken postoperatively and assessed statistically. Thereafter, the 2 groups were followed for time-course changes. There was no significant difference between the 2 groups with regard to time-course changes during the immediate postoperative period. This suggests that maxillary stability after Le Fort I osteotomy for cant correction does not differ from that after Le Fort I osteotomy for maxillary advancement.
Magnus Georg von Paucker (1787-1855) / Eckhard Spring
Spring, Eckhard
2013-01-01
Eestis sündinud ja Tartu Ülikoolis õppinud silmapaistvast baltisaksa teadlasest ja tema lapselapsest Alexandrine Pauckerist. 23. novembril 2012 Jelgavas/Mitaus toimunud Magnus Georg von Pauckerile pühendatud teaduskonverentsist
St. George Feast: Relation to Eastern Legends and Cults [In Bulgarian
Directory of Open Access Journals (Sweden)
S. Rulinski
2016-07-01
Full Text Available The article examines George as a counterpart to the Sumerian god Ninurta. Feast St. George boasts Georgy feat - creation of the world. The date of the feast – 6th of May, is commented in its relation to the astronomical arguments and Sumerian ancient texts. The main rituals of the feast are described. The most typical folk songs devoted to St. Georgy are listed in the paper appendix.
Georges Duby et les Études d'histoire rurale
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Laurent Feller
2008-01-01
Full Text Available Comme tous les grands artistes, Georges Duby a eu plusieurs périodes. Les études d’histoire rurale ont été la première d’entre elles. De 1952 au milieu des années 1970, Georges Duby a eu une production soutenue et, à tous points de vue importante. Il y eut d’abord les grands ouvrages, sa thèse, sur le Mâconnais qui est aussi un ouvrage traitant des questions rurales dans ce qu’elles peuvent avoir de plus concret et de plus élémentaire. En 1962, L’économie rurale et la vie des campagnes marque...
Feltarbejde i Thule. Sammenfiltringen af steder, folk og fortællinger
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Kirsten Hastrup
2016-07-01
Full Text Available På baggrund af lang tids arbejde i Thuleregionen i det nordvestligste Grønland vil jeg diskutere, hvordan steder, folk og fortællinger gensidigt former hinanden. ’Felten’ er således formateret af mange forhold, historiske og nutidige, naturlige og kulturelle, og man må besinde sig på feltens flydende form, selv når den ser mest solid ud. Steder er i sig selv flygtige; de opstår i mødet med mennesker, som tillægger dem betydning. Folk kan se nok så traditionelle ud, men de lever i samme verden som antropologen, der kommer for at lære af dem. Endelig er fortællingerne ikke stivnede vidnesbyrd om tidligere tider; de er tværtimod et vigtigt redskab i håndteringen af højst nutidige udfordringer, som kommer til syne i det endnu ufortalte. Bag fortællingen om Thule ligger en større diskussion af enhver felts plasticitet.
Smithsonian Marine Station (SMS) at Fort Pierce
share current Smithsonian research on the plants and animals of the Indian River Lagoon and marine Smithsonian Marine Station at Fort Pierce Website Search Box Search Field: SMS Website Search Twitter SMS Home ⺠Welcome to the Smithsonian Marine Station Homepage slideshow Who We Are... The
George MacDonald's Estimate of Childhood
Pridmore, John
2007-01-01
The nineteenth-century fantasy writer George MacDonald believed that "it is better to be a child in a green field than a knight of many orders." In this paper, I shall explore the bearing of this high estimate of childhood on spiritual education. MacDonald explores the spirituality of the child in his essay "A Sketch of Individual Development" and…
Final Comments from Professors George and Beane.
Beane, James; George, Paul S.
1996-01-01
Concludes this journal focus section on curriculum integration with transcripts of questions asked by conference attendees and answers by Professors Beane and George. Areas addressed included experience levels with children and teachers, studies that point to the failure of curriculum integration, and how teachers can continue curriculum…
2012-09-25
... To Release Airport Property at the St. George Airport, St. George, UT AGENCY: Federal Aviation... rule and invite public comment on the release of land at St. George Airport under the provisions of..., City of St. George, Utah, at the following address: Mr. Gary Esplin, City Manager, City of St. George...
Il Cabinet d'amateur di Georges Perec
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Valeria Cammarata
2011-06-01
Full Text Available In 1979 one year after the publication of La vie mode d’emploi, George Perec wrote Cabinet d’amateur. Histoire d’un tableau, in which he tells the story of a painting belonging to the genre of the cabinet d’amateur, also known as kunst- und wunderkammer. It is a collection of different paintings, usually belonging to a rich man or a notable, portrayed (once again in a single picture celebrating the magnificence of this more or less real collection. As for the pictorial genre, so the short novel is the celebration of the images collected by George Perec in his previous masterpiece, La vie mode d’emploi. This is why I assume this work to be referable to the genre of structural homology more than to that of ékphrasis, being the pictorial structure not only the thematic inspiration or motif of the novel but its own underlying structure
RadNet Air Data From Fort Smith, AR
This page presents radiation air monitoring and air filter analysis data for Fort Smith, AR from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.
Georgiou, Theodoros; Christopoulos, George; Anastasiadou, Violetta; Hadjiloizou, Stavros; Cregeen, David; Jackson, Marie; Mavrikiou, Gavriella; Kleanthous, Marina; Drousiotou, Anthi
2014-12-01
Tay-Sachs disease (TSD) is a recessively inherited neurodegenerative disorder caused by mutations in the HEXA gene resulting in β-hexosaminidase A (HEX A) deficiency and neuronal accumulation of GM2 ganglioside. We describe the first patient with Tay-Sachs disease in the Cypriot population, a juvenile case which presented with developmental regression at the age of five. The diagnosis was confirmed by measurement of HEXA activity in plasma, peripheral leucocytes and fibroblasts. Sequencing the HEXA gene resulted in the identification of two previously described mutations: the nonsense mutation c.78G>A (p.Trp26X) and the silent mutation c.1305C>T (p.=). The silent mutation was reported once before in a juvenile TSD patient of West Indian origin with an unusually mild phenotype. The presence of this mutation in another juvenile TSD patient provides further evidence that it is a disease-causing mutation. Successful preimplantation genetic diagnosis (PGD) and prenatal follow-up were provided to the couple.
Sorose suured soovid / George Soros ; interv. Neeme Raud
Soros, George, 1930-
2006-01-01
Miljardär ja filantroop George Soros vastab küsimustele, mis puudutavad tema raamatut "Ekslikkuse ajastu", kriitika USA kui maailma korratuse ühe põhjustaja suhtes, terroriohu vähendamist maailmas, avatud ühiskonnast
Georg Franz Buquoy und "La famosissima Notte"
Czech Academy of Sciences Publication Activity Database
Konečný, Lubomír
-, 0016 (2011), s. 1-9 ISSN 2190-3328 Institutional research plan: CEZ:AV0Z80330511 Keywords : Georg Franz August de Longueval, Count Buquoy * Antonio Allegri * Il Correggio Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.riha-journal.org/articles/2011/2011-jan-mar/konecny-buquoy-famosissima-notte
In Praise of George Peabody, 1795-1869.
Parker, Franklin
1994-01-01
One of several papers on self-made millionaire and educational philanthropist George Peabody defends Peabody's philanthropy against those who criticized him as miserly, highlighting his establishment of colleges, libraries, museums, hospitals, and other charities. The paper details his life, work, politics, and death, describing the causes that he…
George A. Towns Elementary School. Atlanta, Georgia
Burt, Ralph H.
1976-01-01
A project testing solar heating and cooling in an existing building, the George A. Towns Elementary School, is intended to provide information on system design and performance, allow the identification and correction of problems encountered in installing large units, and gauge community/user reaction to solar equipment. (Author/MLF)
George F. Kennan and the Division of Europe
Czech Academy of Sciences Publication Activity Database
Smetana, Vít
2013-01-01
Roč. 15, č. 4 (2013), s. 225-232 ISSN 1520-3972 Institutional support: RVO:68378114 Keywords : George F. Kennan * Cold War * U.S. foreign policy Subject RIV: AB - History Impact factor: 0.349, year: 2013
Directory of Open Access Journals (Sweden)
Tamara Grigorowitschs
2008-04-01
Full Text Available O artigo apresenta uma leitura das obras de George H. Mead e Georg Simmel a respeito do conceito processos de socialização à luz de questões suscitadas no interior do domínio da sociologia da infância. Aborda o desenvolvimento do conceito processos de socialização em Simmel e correlaciona as concepções simmelinas com a obra de Mead a respeito do desenvolvimento do self, com o objetivo de definir os processos de socialização na infância. Visa demonstrar como as obras de Simmel e Mead permitem pensar a infância como um período específico dos processos de socialização, em que as crianças desempenham papéis ativos na construção de seus selves individuais e da sociedade e cultura em que estão inseridas.This paper presents an analysis of George H. Mead's and Georg Simmel's works about the concept of socialization processes in the light of questions arised in the scope of childhood sociology. It approaches the development of Simmel's socialization processes concept and establishes a correlation between the Simmelian conceptions and Mead's work about the self development, in an attempt to define the socialization processes in childhood. It is intended to demonstrate how Simmel's and Mead's works allow us to think about childhood as a specific period of the socialization processes in which children play active roles in building their individual selves, as well as the society and culture they are in.
Slaget ved Vejle og andre fortællinger fra Jyske Bank
DEFF Research Database (Denmark)
Albrechtsen, Charlotte
Storytelling som ledelsesværktøj er en form for retorik idet formålet med at bruge fortællinger i kommunikationen fra ledelse til medarbejdere er at påvirke modtagerne/medarbejderne. Imidlertid er refleksioner over modtagerinstansen så godt som fraværende både i den populære debat om storytelling...... og i den eksisterende forskning i emnet. Foruden at introducere til forskningen i storytelling præsenterer artiklens forfatter, som er ph.d.-studerende, en modtagerorienteret analyse af en fortælling fra Jyske Bank....
DiGeorge Syndrome: a not so rare disease
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Angela BF Fomin
2010-01-01
Full Text Available INTRODUCTION: The DiGeorge Syndrome was first described in 1968 as a primary immunodeficiency resulting from the abnormal development of the third and fourth pharyngeal pouches during embryonic life. It is characterized by hypocalcemia due to hypoparathyroidism, heart defects, and thymic hypoplasia or aplasia. Its incidence is 1:3000 live births and, despite its high frequency, little is known about its natural history and progression. ←This is probably due to diagnostic difficulties and the great variety of names used to describe it, such as velocardiofacial, Shprintzen, DiGeorge, and CATCH 22 Syndromes, as well as conotruncal facial anomaly. All represent the same genetic condition, chromosome 22q11.2 deletion, which might have several clinical expressions. OBJECTIVES: To describe clinical and laboratorial data and phenotypic characteristics of patients with DiGeorge Syndrome. METHODS: Patients underwent standard clinical and epidemiological protocol and tests to detect heart diseases, facial abnormalities, dimorphisms, neurological or behavioral disorders, recurrent infections and other comorbidities. RESULTS: Of 14 patients (8m - 18y11m, only one did not have 22q11.2 deletion detected. The main findings were: conotruncal malformation (n = 12, facial abnormalities (n = 11, hypocalcemia (n = 5 and low lymphocyte count (n=2. CONCLUSION: The authors pointed out the necessity of DGS suspicion in all patient presenting with heart defects, facial abnormalities (associated or not with hypocalcemia, and immunological disorders because although frequency of DGS is high, few patients with a confirmed diagnosis are followed up.
Briggs, Richard W.; Wesnousky, Steven G.; Brune, James N.; Purvance, Matthew D.; Mahan, Shannon
2013-01-01
The Fort Sage Mountains fault zone is a normal fault in the Walker Lane of the western Basin and Range that produced a small surface rupture (L 5.6 earthquake in 1950. We investigate the paleoseismic history of the Fort Sage fault and find evidence for two paleoearthquakes with surface displacements much larger than those observed in 1950. Rupture of the Fort Sage fault ∼5.6 ka resulted in surface displacements of at least 0.8–1.5 m, implying earthquake moment magnitudes (Mw) of 6.7–7.1. An older rupture at ∼20.5 ka displaced the ground at least 1.5 m, implying an earthquake of Mw 6.8–7.1. A field of precariously balanced rocks (PBRs) is located less than 1 km from the surface‐rupture trace of this Holocene‐active normal fault. Ground‐motion prediction equations (GMPEs) predict peak ground accelerations (PGAs) of 0.2–0.3g for the 1950 rupture and 0.3–0.5g for the ∼5.6 ka paleoearthquake one kilometer from the fault‐surface trace, yet field tests indicate that the Fort Sage PBRs will be toppled by PGAs between 0.1–0.3g. We discuss the paleoseismic history of the Fort Sage fault in the context of the nearby PBRs, GMPEs, and probabilistic seismic hazard maps for extensional regimes. If the Fort Sage PBRs are older than the mid‐Holocene rupture on the Fort Sage fault zone, this implies that current GMPEs may overestimate near‐fault footwall ground motions at this site.
"Georg" : za 13 sjomotshnõhh dnei do filma / Marko Matvere ; intervjueerinud Boris Tuch
Matvere, Marko, 1968-
2006-01-01
Peeter Simmi mängufilmi "Georg" võtteperioodi lõpuni on jäänud loetud päevad. Filmist ja oma tegelaskujust räägivad näitlejad Marko Matvere, Anastasia Makejeva (artiklis ekslikult Matvejeva), laulja Renars Kaupers. Filmi stsenarist Mati Põldre räägib Georg Otsa ja KGB suhetest
Lemieux, M. Joanne; Mark, Brian L.; Cherney, Maia M.; Withers, Stephen G.; Mahuran, Don J.; James, Michael N. G.
2010-01-01
Lysosomal β-hexosaminidase A (Hex A) is essential for the degradation of GM2 gangliosides in the central and peripheral nervous system. Accumulation of GM2 leads to severely debilitating neurodegeneration associated with Tay-Sachs disease (TSD), Sandoff disease (SD) and AB variant. Here, we present the X-ray crystallographic structure of Hex A to 2.8 Å resolution and the structure of Hex A in complex with NAG-thiazoline, (NGT) to 3.25 Å resolution. NGT, a mechanism-based inhibitor, has been shown to act as a chemical chaperone that, to some extent, prevents misfolding of a Hex A mutant associated with adult onset Tay Sachs disease and, as a result, increases the residual activity of Hex A to a level above the critical threshold for disease. The crystal structure of Hex A reveals an αβ heterodimer, with each subunit having a functional active site. Only the α-subunit active site can hydrolyze GM2 gangliosides due to a flexible loop structure that is removed post-translationally from β, and to the presence of αAsn423 and αArg424. The loop structure is involved in binding the GM2 activator protein, while αArg424 is critical for binding the carboxylate group of the N-acetyl-neuraminic acid residue of GM2. The β-subunit lacks these key residues and has βAsp452 and βLeu453 in their place; the β-subunit therefore cleaves only neutral substrates efficiently. Mutations in the α-subunit, associated with TSD, and those in the β-subunit, associated with SD are discussed. The effect of NGT binding in the active site of a mutant Hex A and its effect on protein function is discussed. PMID:16698036
FORT NAMUTONI: FROM MILITARY STRONGHOLD TO TOURIST ...
African Journals Online (AJOL)
STRONGHOLD TO TOURIST CAMP. Col Dr Jan Ploeger*. "... this fortress was not just a white elephant, it was actually occupied and played a major role in the settlement of Germans in the far North." (own translation) - D.W. Krynauw Die Verhaal van. Namutoni, p 3. Introduction. Fort Namutoni, the last White outpost east of ...
Language, literature and theory in Georges Perec
Directory of Open Access Journals (Sweden)
Jacques Fux
2013-07-01
Full Text Available This article approaches some possible relations between space and literature within the work of the French writer Georges Perec. The book Espèces d’espaces, published in 1974, is taken as a major reference for a reflection about how its narrative structure produces displacements in its fictional status.
2013-05-15
...] Notice of Approval of Record of Decision for Extending F-Line Streetcar Service to Fort Mason Center... Environmental Impact Statement (Final EIS) for extending the F-Line historic streetcar service to Fort Mason... turnaround terminus at the Fort Mason Center; and installing appurtenant features such as signals, crossings...
Initial-boundary-value problem of the self-gravitating scalar field in the Bondi-Sachs gauge
International Nuclear Information System (INIS)
Frittelli, Simonetta; Gomez, Roberto
2007-01-01
It is shown that, in the Bondi-Sachs gauge that fixes the speed of incoming light rays to the value 1, the Einstein equations coupled to a scalar field in spherical symmetry are cast into a symmetric-hyperbolic system of equations for the scalar field, lapse and shift as fundamental variables. In this system of equations, the lapse and shift are incoming characteristic fields, and the scalar field has three components: incoming, outgoing and static. A constraint-preserving boundary condition is prescribed by imposing the projection of the Einstein equation normal to the boundary at the outer value of the radial coordinate. The boundary condition specifies one of the two incoming metric fields. The remaining incoming metric field and the incoming scalar field component need to be specified arbitrarily. Numerical simulations of the scattering of the scalar field by a black hole in the nonlinear regime are presented that illustrate interesting facts about black-hole physics and the behavior of the characteristic variables of the problem
2012-12-03
... Smith, AR; Notice of Revised Determination on Reconsideration On August 8, 2012, the Department of Labor... workers and former workers of Huntington Foam LLC, Fort Smith, Arkansas (subject firm). The workers are... reconsideration investigation, I determine that workers of Huntington Foam LLC, Fort Smith, Arkansas, who were...
Bulgaria and Serbia in the historical works of George Akropolites and George Pachymeres
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Stanković Vlada
2009-01-01
Full Text Available The paper analyzes the well-known historical works of George Akropolites and George Pachymeres from the viewpoint of their literary composition structure, lexica and narrative techniques used for describing events and personalities from Bulgaria and Serbia. An attempt is made to surpass the 'traditional' methodology and the usually applied standard approach that focuses almost exclusively to the search for the 'strong' historical facts in these literary works par excellence, in that way overlooking their strong literary character, careful expressions, sometimes evident and sometimes more subtle style differences whose purpose was to underline the focal points and the conclusions of the content of the stories - in short, the information and the stories about Bulgaria and Serbia by Akropolites and Pachymeres are analyzed in their entirety, viewed as the integral parts of the complex literary works, and not as isolated episodes, divided from the rest of the narrative. The ways in which George Akropolites depicted and described deaths of the Bulgarian rulers were studied as one of the best examples of his conscious endeavors to bring the literary style of his History in accord with his own judgments about the rulers of the neighboring country. Scenes of death, conspicuously frequent in Akropolites' relatively short historical work, play an important role in characterizing personalities, and the same principle which Akropolites uses for judging the Byzantines is applied to the Bulgarians as well: generally positive opinion about somebody's life and achievements is emphasized with a depiction of his death in a positive way (Ivan II Asen, and vice versa, Akropolites' 'villains' receive their horrible deaths as a deserved punishment for their bad deeds (Kalojan's death. On the other hand, Akropolites' scarce information about Serbs is supplemented with his depiction of the Serbian king Uroš (1243-1276, and his stance after the death of John Batatzes
Maxillary distraction osteogenesis at Le Fort-I level induces bone apposition at infraorbital rim.
Rattan, Vidya; Jena, Ashok Kumar; Singh, Satinder Pal; Utreja, Ashok Kumar
2014-09-01
The aim of this study is to evaluate whether there is any remodeling of bone at infraorbital rim following maxillary distraction osteogenesis (DO) at Le Fort-I level. Twelve adult subjects in the age range of 17-21 years with complete unilateral cleft lip and palate underwent advancement of the maxilla by DO. The effect of maxillary DO on the infraorbital rim remodeling was evaluated from lateral cephalograms recorded prior to the DO (T0), at the end of DO (T1), and at least 2-years after the DO (T2) by Walker's analysis. The ANOVA and two-tailed t test were used and probability value (P value) 0.05 was considered as statistically significant level. There was anterior movement of maxilla by 9.22 ± 3.27 mm and 7.67 ± 3.99 mm at the end of immediate (T1) and long-term (T2) follow-up of maxillary DO, respectively. The Walker's analysis showed 1.49 ± 1.22 mm and 2.31 ± 1.81 mm anterior movement of the infraorbital margin (Orbitale point) at the end of T1 and T2, respectively (P distraction osteogenesis at Le Fort-I level induced significant bone apposition at infraorbital rim. Patients with mild midface hypoplasia who would otherwise may be candidates for osteotomy at Le Fort-II or Le Fort-III level may benefit from maxillary distraction at Le Fort-I level.
Soros, George, 1930-
2004-01-01
George Soros vastab küsimustele, kas postkommunistlikel riikidel oleks olnud mõttekas ja võimalik valida veidi pehmem tee turumajandusele üleminekul, kas ta usub liberaalse demokraatia lõplikku võidukäiku maailmas, millised on suurimad ohud tänapäeva maailma ees, samuti küsimustele demokraatlike riikide alliansi otstarbe ja mahajäänud ühiskondade jaluleaitamise kohta
Directory of Open Access Journals (Sweden)
Àngels Santa
2014-04-01
Full Text Available A propósito de las obras de George Sand, Œuvres complètes. Sous la direction de Béatrice Didier. 1841-1842.Un hiver à Majorque. Édition critique par Angela Ryan. Horace.Édition critique par Jeanne Brunereau (París, Honoré Champion, 2013, 748 p. ISBN : 9782745319265 y Œuvres complètes. ́Sous la direction de Béatrice Didier. 1849.La petite Fadette. Édition critique par Andrée Mansau (París, Honoré Champion, 2013, 345p. ISBN : 9782745319203
Wood-Fired Boiler System Evaluation at Fort Stewart, GA
National Research Council Canada - National Science Library
Potts, Noel
2002-01-01
Part of the plan to modernize the central energy plant (CEP) at Fort Stewart, GA is focused on the installations wood-fired boiler, which provides steam for heating, cooling, and domestic hot water. The U.S...
Kato, Atsushi; Nakagome, Izumi; Nakagawa, Shinpei; Kinami, Kyoko; Adachi, Isao; Jenkinson, Sarah F; Désiré, Jérôme; Blériot, Yves; Nash, Robert J; Fleet, George W J; Hirono, Shuichi
2017-11-15
The affinity of a series of iminosugar-based inhibitors exhibiting various ring sizes toward Hex A and their essential interactions with the enzyme active site were investigated. All the Hex A-inhibiting iminosugars tested formed hydrogen bonds with Arg178, Asp322, Tyr421 and Glu462 and had the favorable cation-π interaction with Trp460. Among them, DMDP amide (6) proved to be the most potent competitive inhibitor with a K i value of 0.041 μM. We analyzed the dynamic properties of both DMDP amide (6) and DNJNAc (1) in aqueous solution using molecular dynamics (MD) calculations; the distance of the interaction between Asp322 and 3-OH and Glu323 and 6-OH was important for stable interactions with Hex A, reducing fluctuations in the plasticity of the active site. DMDP amide (6) dose-dependently increased intracellular Hex A activity in the G269S mutant cells and restored Hex A activity up to approximately 43% of the wild type level; this effect clearly exceeded the border line treatment for Tay-Sachs disease, which is regarded as 10-15% of the wild type level. This is a significantly greater effect than that of pyrimethamine, which is currently in Phase 2 clinical trials. DMDP amide (6), therefore, represents a new promising pharmacological chaperone candidate for the treatment of Tay-Sachs disease.
Gort, Laura; de Olano, Natalia; Macías-Vidal, Judit; Coll, M A Josep
2012-09-10
The GM2 gangliosidoses are autosomal recessive lysosomal storage diseases caused by a deficiency of the β-hexosaminidase A enzyme. This enzyme is composed of two polypeptide chains designated the α- and β- subunits and it interacts with the GM2 activator protein. The HEXA and HEXB genes encode the α-subunit and the β-subunit, respectively. Mutations in these genes are causative of Tay-Sachs disease (HEXA) and Sandhoff disease (HEXB). We analyzed the complete HEXA gene in 34 Spanish patients with Tay-Sachs disease and the HEXB gene in 14 Spanish patients with Sandhoff disease. We identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB gene, and we attempted to correlate these mutations with the clinical presentation of the patients. We found a high frequency of c.459+5G>A (IVS4+5G>A) mutation in HEXA affected patients, 22 of 68 alleles, which represent the 32.4%. This is the highest percentage found of this mutation in a population. All patients homozygous for mutation c.459+5G>A presented with the infantile form of the disease and, as previously reported, patients carrying mutation p.R178H in at least one of the alleles presented with a milder form. In HEXB affected patients, the novel deletion c.171delG accounts for 21.4% of the mutant alleles (6/28). All patients with this deletion showed the infantile form of the disease. The Spanish GM2 gangliosidoses affected patients show a great mutational heterogeneity as seen in other inherited lisosomal diseases in this country. Copyright © 2012. Published by Elsevier B.V.
Characterization of inducible models of Tay-Sachs and related disease.
Sargeant, Timothy J; Drage, Deborah J; Wang, Susan; Apostolakis, Apostolos A; Cox, Timothy M; Cachón-González, M Begoña
2012-09-01
Tay-Sachs and Sandhoff diseases are lethal inborn errors of acid β-N-acetylhexosaminidase activity, characterized by lysosomal storage of GM2 ganglioside and related glycoconjugates in the nervous system. The molecular events that lead to irreversible neuronal injury accompanied by gliosis are unknown; but gene transfer, when undertaken before neurological signs are manifest, effectively rescues the acute neurodegenerative illness in Hexb-/- (Sandhoff) mice that lack β-hexosaminidases A and B. To define determinants of therapeutic efficacy and establish a dynamic experimental platform to systematically investigate cellular pathogenesis of GM2 gangliosidosis, we generated two inducible experimental models. Reversible transgenic expression of β-hexosaminidase directed by two promoters, mouse Hexb and human Synapsin 1 promoters, permitted progression of GM2 gangliosidosis in Sandhoff mice to be modified at pre-defined ages. A single auto-regulatory tetracycline-sensitive expression cassette controlled expression of transgenic Hexb in the brain of Hexb-/- mice and provided long-term rescue from the acute neuronopathic disorder, as well as the accompanying pathological storage of glycoconjugates and gliosis in most parts of the brain. Ultimately, late-onset brainstem and ventral spinal cord pathology occurred and was associated with increased tone in the limbs. Silencing transgenic Hexb expression in five-week-old mice induced stereotypic signs and progression of Sandhoff disease, including tremor, bradykinesia, and hind-limb paralysis. As in germline Hexb-/- mice, these neurodegenerative manifestations advanced rapidly, indicating that the pathogenesis and progression of GM2 gangliosidosis is not influenced by developmental events in the maturing nervous system.
Characterization of inducible models of Tay-Sachs and related disease.
Directory of Open Access Journals (Sweden)
Timothy J Sargeant
2012-09-01
Full Text Available Tay-Sachs and Sandhoff diseases are lethal inborn errors of acid β-N-acetylhexosaminidase activity, characterized by lysosomal storage of GM2 ganglioside and related glycoconjugates in the nervous system. The molecular events that lead to irreversible neuronal injury accompanied by gliosis are unknown; but gene transfer, when undertaken before neurological signs are manifest, effectively rescues the acute neurodegenerative illness in Hexb-/- (Sandhoff mice that lack β-hexosaminidases A and B. To define determinants of therapeutic efficacy and establish a dynamic experimental platform to systematically investigate cellular pathogenesis of GM2 gangliosidosis, we generated two inducible experimental models. Reversible transgenic expression of β-hexosaminidase directed by two promoters, mouse Hexb and human Synapsin 1 promoters, permitted progression of GM2 gangliosidosis in Sandhoff mice to be modified at pre-defined ages. A single auto-regulatory tetracycline-sensitive expression cassette controlled expression of transgenic Hexb in the brain of Hexb-/- mice and provided long-term rescue from the acute neuronopathic disorder, as well as the accompanying pathological storage of glycoconjugates and gliosis in most parts of the brain. Ultimately, late-onset brainstem and ventral spinal cord pathology occurred and was associated with increased tone in the limbs. Silencing transgenic Hexb expression in five-week-old mice induced stereotypic signs and progression of Sandhoff disease, including tremor, bradykinesia, and hind-limb paralysis. As in germline Hexb-/- mice, these neurodegenerative manifestations advanced rapidly, indicating that the pathogenesis and progression of GM2 gangliosidosis is not influenced by developmental events in the maturing nervous system.
Probing the integrated Sachs-Wolfe effect using embedded lens models
Chen, B.; Kantowski, R.
2015-04-01
The photometry profile of the integrated Sachs-Wolfe (ISW) effect, recently obtained by the Planck consortium by stacking patches of cosmic microwave background (CMB) sky maps around a large number of cosmic voids, contains a cold ring at about half the void's effective radius surrounded by a hot ring near the void's boundary. The source of the temperature structure is assumed to be the ISW effect but the exact cause of the ringed structure is not currently well understood, particularly the outer hot ring. Numerical simulations have suggested that hot/cold ring structures can be produced by motions associated with nonlinear growths of cosmic structures whose gravitational potentials produce the ISW effect. We have recently developed the embedded lens theory and the Fermat potential formalism which can be used to model the ISW effect caused by intervening individual lens inhomogeneities evolving arbitrarily. This theory only requires knowledge of the void's projected mass profile as a function of the passing CMB photons' impact radius and the rate of change of that mass distribution at passage. We present two simple embedded void lens models with evolving mass densities and investigate the ISW effect caused by these lenses. Both models possess expanding mass shells which produce hot rings around central cold regions, consistent with the recent observations. By adding a small overdensity at the void's center we can produce the slight positive temperature excess hinted at in Planck's photometric results. We conclude that the embedded lens theory and the Fermat potential formalism is well suited for modeling the ISW effect.
Wind resource assessment and wind energy system cost analysis: Fort Huachuca, Arizona
Energy Technology Data Exchange (ETDEWEB)
Olsen, T.L. [Tim Olsen Consulting, Denver, CO (United States); McKenna, E. [National Renewable Energy Lab., Golden, CO (United States)
1997-12-01
The objective of this joint DOE and National Renewable Energy Laboratory (NREL) Strategic Environmental Research and Development Program (SERDP) project is to determine whether wind turbines can reduce costs by providing power to US military facilities in high wind areas. In support of this objective, one year of data on the wind resources at several Fort Huachuca sites was collected. The wind resource data were analyzed and used as input to an economic study for a wind energy installation at Fort Huachuca. The results of this wind energy feasibility study are presented in the report.
Surgical risk factors and maxillary nerve function after le fort I osteotomy
DEFF Research Database (Denmark)
Thygesen, Torben Henrik; Jensen, Allan Bardow; Norholt, SE
2009-01-01
PURPOSE: Data on intraoperative risk factors for long-term postoperative complications after Le Fort I osteotomy (LFO) are limited. The aim of this study was to describe prospectively the overall postoperative changes in maxillary nerve function after LFO, and to correlate these changes with a nu......PURPOSE: Data on intraoperative risk factors for long-term postoperative complications after Le Fort I osteotomy (LFO) are limited. The aim of this study was to describe prospectively the overall postoperative changes in maxillary nerve function after LFO, and to correlate these changes...
Let Slip the Dogs of (CYBER) War: Progressing Towards a Warfighting U.S. Cyber Command
2013-04-01
requirements, nor a headquarters building (it is currently housed within NSA facilities on Fort George G. Meade , MD).22 In addition, the DOD cyber...Information Conflict: National Security Law in Cyberspace (Falls Church, VA: Aegis Research Corporation, 2000); Herbert Lin, “Offensive Cyber Operations...this legislation was pocket-vetoed by then President George H.W. Bush due to a lack of consistency between the stated intent of the oversight
2013-12-16
... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Supplemental Environmental Impact Statement for the Route 460 Location Study, Prince George County to Suffolk, Virginia AGENCY: Federal... roughly parallel to the existing Route 460 corridor between Interstate 295 in Prince George County and...
St George the dragon-slayer at Prague Castle - the eternal pilgrim without a home?
Czech Academy of Sciences Publication Activity Database
Benešovská, Klára
2007-01-01
Roč. 55, č. 1 (2007), s. 28-39 ISSN 0049-5123 Institutional research plan: CEZ:AV0Z80330511 Keywords : Gothic bronze sculpture * St George the dragon -slayer * Martin and George of Cluj * Prague Castle Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.umeni-art.cz/cz/soubory/benesovska.pdf
Pinker, Steven
2013-01-01
Presents an obituary for George A. Miller (1920—2012). Miller ranks among the most important psychologists of the 20th century. In addition to writing one of the best known papers in the history of psychology (“The Magical Number Seven, Plus or Minus Two: Some Limits on Our Capacity for Processing Information,” published in Psychological Review in 1956), Miller also fomented the cognitive revolution, invented psycholinguistics and cognitive psychology, imported powerful ideas from the theorie...
Autobiography of Sir George Biddell Airy
Airy, George Biddell; Airy, Wilfred
2010-06-01
Preface; 1. Personal sketch of George Biddell Airy; 2. From his birth to his taking his B.A. degree; 3. At Trinity College, Cambridge; 4. At Cambridge Observatory; 5. At Greenwich Observatory, 1836-1846; 6. At Greenwich Observatory, 1846-1856; 7. At Greenwich Observatory, 1856-1866; 8. At Greenwich Observatory, 1866-1876; 9. At Greenwich Observatory to his resignation in 1881; 10. At the White House, Greewich, to his death; Appendix: List of printed papers; Index.
Status of the Fort St. Vrain decommissioning
International Nuclear Information System (INIS)
Fisher, M.J.
1990-01-01
Fort St. Vrain is a high temperature gas cooled reactor. It has been shut down as a result of financial and technical difficulties. Fort St. Vrain has been planning for defueling and decommissioning for at least three years. The preliminary decommissioning plan, in accordance with the NRC's final rule, has been submitted and is being reviewed by the NRC. The basis of the preliminary decommissioning plan has been SAFSTOR. Public Service Company, who is the owner and operator of FSV, is scheduled to submit a proposed decommissioning plan to the NRC in the fourth quarter of 1990. PSC has gone out for bid on the decontamination and dismantlement of FSV. This paper includes the defueling schedule, the independent spent fuel storage installation status, the probability of shipping fuel to DOE, the status of the preliminary decommissioning plan submittal, the issuance of a possession only license and what are the results of obtaining this license amendment, preliminary decommissioning activities allowed prior to the approval of a proposed decommissioning plan, the preparation of a proposed decommissioning plan and the status of our decision to proceed with SAFSTOR or DECON as identified in the NRC's final decommissioning rule
Strategic Analysis and Plan for Implementing Telemedicine at Fort Greely
National Research Council Canada - National Science Library
Bolton, Karl
2003-01-01
.... To best accomplish this, a strategic analysis and business case analysis was conducted. Introspective strategic analysis tools revealed an organization that is capable of supporting a telemedicine program at Fort Greely...
Catalog of the George Alan Connor Esperanto Collection.
Smith, Karin, Comp.; Haake, Susan, Comp.
This catalog inventories the collection of books, monographs, serials and periodicals, dictionaries, pamphlets, ephemera, and correspondence concerning Esperanto in the collection of George Alan Connor housed at the University of Oregon Library. Overall, the catalog contains approximately 475 serial entries and 3,000 author entries. Connor was a…
The Fort Smith radioactive belt, Northwest Territories
International Nuclear Information System (INIS)
Charbonneau, B.W.
1980-01-01
The Fort Smith Belt is an elongate zone, about 200 km x 50 km, extending from the East Arm of Great Slave Lake southerly into northeastern Alberta. The major feature of the belt is that it is one of the most radioactive regions so far recognized in the Canadian Shield. Potassium, uranium, and thorium are all enriched but the greatest increase is in thorium. The dominant rock type underlying the area is a foliated porphyritic granite. This rock contains an average of about 80 ppm thorium (with areas of tens of square kilometres containing up to 200 ppm) and approximately 11 ppm uranium. In places, dark elongate zones rich in biotite, apatite, and opaque minerals within the porphyritic granite may contain an order of magnitude more uranium and thorium than the porphyry. Radioactive minerals within both the porphyry and the dark zones are principally monazite (containing up to 16% ThO 2 ) and isolated grains of uraninite. This foliated porphyritic granite is interpreted as being pre- or syntectonic with respect to the Hudsonian event because its foliation parallels that of the surrounding rocks. There has been subsequent deformation. The second characteristic feature of the Fort Smith Belt is the development of a peripheral zone where eU is enriched relative to eTh correlating mainly with granitoid rocks which surround the thorium-rich area and wherein ratios of eU/eTh exceed 1:2 (compared to the crustal average of 1:4). Uranium may have moved laterally into this marginal area from the thorium-rich porphyry, possibly in a vapour phase. There is a possibility that concentrations of uranium as well as other metals such as Cu, Mo, Zn, Sn, and W could exist in the porphyry and its margin in appropriate chemical and/or structural traps. The radioactive granite rocks of the Fort Smith Belt are adjacent to uranium-thorium occurrences in the nearby Proterozoic Nonacho sediments but whether or not a genetic relationship exists between the two situations is uncertain. (auth)
2004-06-18
of Sickle,” World War II Magazine, November 2003, 59. 11Ibid., 60. 12Abbeville is 100 miles north of Paris near the English Channel. 13T. N. Mout... catacombs of Fort Eben Emael. A further understanding of the dynamics of the fort and her defenders can be gained by the knowledge that that fort was...Green Devils German Paratroopers 1939-45 ( Paris , France: Histories & Collections, 1997), 27. Helmut Wenzl (Left in photo) Born - 10 March
2010-07-07
... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-73,416] Desoto Mills LLC, Fort... applicable to workers and former workers at Desoto Mills, LLC, a Subsidiary of Fruit of the Loom, Fort Payne... * * * locations outside the Desoto Mills Plant.'' The petitioner compares the situation at this location with...
Christodoulakis, T.; Papadopoulos, G. O.
2002-10-01
Following the spirit of a previous work of ours, we investigate the group of those general coordinate transformations (GCTs) which preserve manifest spatial homogeneity. In contrast to the case of Bianchi type models, here we permit an isometry group of motions G4 = SO(3) ⊗ Tr, where Tr is the translations group, along the radial direction, while SO(3) acts multiply transitively on each hypersurface of simultaneity Σt. The basis 1-forms cannot be invariant under the action of the entire isometry group and hence produce an open Lie algebra. In order for these GCTs to exist and have a nontrivial, well-defined action, certain integrability conditions have to be satisfied; their solutions, exhibiting the maximum expected 'gauge' freedom, can be used to simplify the generic, spatially homogeneous, line element. In this way an alternative proof of the generality of the Kantowski-Sachs (KS) vacuum is given, while its most general, manifestly homogeneous, form is explicitly presented.
FIND: Fort Calhoun Station, Unit 2
International Nuclear Information System (INIS)
Williams, W.H.
1976-07-01
This index is presented for the microfiche material of Docket 50548 which concerns the application of Omaha Public Power District to build and operate Fort Calhoun Station, Unit 2. The information includes both application and review material dated from September 1975 through March 1976. There are five amendments to the PSAR and one supplement to the ER which have been incorporated by reference into the respective reports. Docket RESAR-3 is used as a reference for portions of the PSAR
ALARA and decommissioning: The Fort St. Vrain experience
Energy Technology Data Exchange (ETDEWEB)
Borst, T.; Niehoff, M. [Public Service Co. of Colorado, Platteville, CO (United States); Zachary, M. [Scientific Ecology Group, Platteville, CO (United States)
1995-03-01
The Fort St. Vrain Nuclear Generating Station, the first and only commercial High Temperature Gas Cooled Reactor to operate in the United States, completed initial fuel loading in late 1973 and initial startup in early 1974. Due to a series of non-nuclear technical problems, Fort St. Vrain never operated consistently, attaining a lifetime capacity factor of slightly less than 15%. In August of 1989, the decision was made to permanently shut down the plant due to control rod drive and steam generator ring header failures. Public Service Company of Colorado elected to proceed with early dismantlement (DECON) as opposed to SAFSTOR on the bases of perceived societal benefits, rad waste, and exposure considerations, regulatory uncertainties associated with SAFSTOR, and cost. The decommissioning of Fort St. Vrain began in August of 1992, and is scheduled to be completed in early 1996. Decommissioning is being conducted by a team consisting of Westinghouse, MK-Ferguson, and Scientific Ecology Group. Public Service Company of Colorado as the licensee provides contract management and oversight of contractor functions. An aggressive program to maintain project radiation exposures As Low As Reasonably Achievable (ALARA) has been established, with the following program elements: temporary and permanent shielding contamination control; mockup training; engineering controls; worker awareness; integrated work package reviews communication; special instrumentation; video camera usage; robotics application; and project committees. To date, worker exposures have been less than project estimates. from the start of the project through Februrary of 1994, total exposure has been 98.666 person-rem, compared to the project estimate of 433 person-rem and goal of 347 person-rem. The presentation will discuss the site characterization efforts, the radiological performance indicator program, and the final site release survey plans.
Hans Joas & Daniel R. Huebner (eds.), The Timeliness of George Herbert Mead
Baggio, Guido
2018-01-01
The Timeliness of George Herbert Mead is a significant contribution to the recent “Mead renaissance.” It gathers some contributions first presented at the conference celebrating the 150th anniversary of the birth of George Herbert Mead held in April 2013 at the University of Chicago and organized by Hans Joas, Andrew Abbott, Daniel Huebner, and Christopher Takacs. The volume brings scholarship on G. H. Mead up to date highlighting Mead’s relevance for areas of research completely ignored by p...
Opening remarks for the Fort Valley Centennial Celebration
G. Sam Foster
2008-01-01
The Rocky Mountain Research Station recognizes and values the contributions of our scientists and collaborators for their work over the past century at Fort Valley Experimental Forest. With the help of our partners and collaborators, Rocky Mountain Research Station is working to improve coordination across its research Program Areas and Experimental Forests and Ranges...
Joseph E. Crouse; Peter Z. Fule
2008-01-01
The landscape surrounding the Fort Valley Experimental Forest in northern Arizona has changed dramatically in the past decade due to the Fort Valley Restoration Project, a collaboration between the Greater Flagstaff Forest Partnership, Coconino National Forest, and Rocky Mountain Research Station. Severe wildfires in 1996 sparked community concern to start restoration...
Fortællinger om sorg og tab – når det personlige bliver socialt?
DEFF Research Database (Denmark)
Christensen, Dorthe Refslund; Sandvik, Kjetil
2016-01-01
Vi fortæller om døden, om det at miste og føle sorg. Kulturhistorisk er litteratur, teater og malerkunst scener for netop dette emne. Som socialt fænomen ser vi dog ikke i samme omfang fortællinger om død, tab og sorg, eftersom emnet typisk har været anskuet som et privat anliggende. Bestemte...
International Nuclear Information System (INIS)
Nguyen, C.; Gold, R.J.M.; Mahuran, D.; Lowden, J.A.
1981-01-01
Tay-Sachs disease results from a loss of activity of hexosaminidase A (HEX A) in body tissues and fluids. Heterozygotes for the disease are usually identified by their relatively low ratio of heat-labile HEX A to total hexosaminidase. During pregnancy an intermediate isoenzyme (HEX I) increases in activity in serum and obscures the heterozygote status. HEX I does not increase in leucocytes, tears and other body tissues but because of technical difficulties in these assays the authors examined the feasibility of using a radioimmunoassay for HEX A. By univariate analysis, the heat denaturation assay gave a lower cost of misclassification for non-pregnant normals while RIA did so for pregnant normals. A combination of both tests led to reduced cost of misclassification compared to either alone. Bayesian analysis of bivariate gaussian density functions for heat denaturation and for radioimmunoassays of HEX isoenzymes was employed to calculate misclassification frequencies. Among the parameters examined, HEX A measured by RIA and % HEX A by heat-denaturation assay were the two having the best discriminatory power. (Auth.)
THE ONEIRIC AUTOBIOGRAPHY OF GEORGES PEREC.
Schwartz, Henry P
2016-01-01
Georges Perec's book La Boutique Obscure (1973; translated into English in 2012) serves as the basis for this paper. The book is a collection of dreams that its author dreamed from May 1968 to August 1972. The present author treats these dreams as chapters in a bizarre autobiography, elaborating Perec's life through a discussion of those dreams and using them as a starting point with which to discuss his views of dream interpretation and the role of dreams in psychoanalysis. © 2016 The Psychoanalytic Quarterly, Inc.
Analysis and evaluation of recent operational experience from the Fort St. Vrain HTGR
International Nuclear Information System (INIS)
Moses, D.L.; Lanning, W.D.
1985-05-01
The Fort St. Vrain operating experience to be discussed here includes notable safety-related events which have occurred since late 1981 when ORNL was first contracted to provide technical assistance to AEOD. Earlier Fort St. Vrain operating experience through the time of successful full-power testing in November 1981 has been summarized by the licensee and the reactor vendor, GA Technologies, Inc. (GA), in papers presented at several different forums during 1982. In addition, extensive and very useful detailed evaluations of preoperational and startup testing and of the rise-to-power operating experience through completion of the first refueling outage in August 1979 have been compiled into a series of reports under the sponsorship of the Electric Power Research Institute (EPRI). Finally, the US Department of Energy's Fort St. Vrain Improvement Plan provides a summary of the major operational limits which have affected the plant since start-up. The events discussed here are categorized based on the major systems affected, namely, (1) primary system and reactor vessel, (2) electrical systems, and (3) the reactor building. In all cases to be discussed, the lessons to be learned are vigilance and prevention. These lessons translate into the need for the recognition and control of unexpected situations and of their potential for branching effects. At Fort St. Vrain, these lessons are found in the effects of moisture ingress, in the challenges experienced to the supply of essential electrical power, and in controlling the environment of the reactor building. 13 refs
Hawking, Lucy; Parsons, Gary
2015-01-01
À Foxbridge, Georges et Annie s'ennuient, ils rêvent de repartir dans l'espace pour de nouvelles aventures intergalactiques. Pourtant, sur la terre ferme, il se passe des choses étranges... L'argent s'envole des distributeurs de billets, les avions refusent de décoller et les caisses enregistreuses des supermarchés ne fonctionnent plus... Quel chaos ! Il semblerait qu'un bug planétaire ait déréglé tous les systèmes informatiques. S'ils veulent découvrir ce qui se cache derrière tout ça, les deux amis devront voyager plus loin que jamais dans l'espace...
Georges Perec's literary staging
Directory of Open Access Journals (Sweden)
Ewelina Woźniak-Czech
2017-12-01
Full Text Available The purpose of this sketch to present Georges Perec’s work in the context of drama. As Perec wrote just one play for the theater, it’s hard to call him a dramatist. However, it is easy to see that all the literary tricks he uses in his works are a part of a well-thought-out game. The author of Life a User’s Manual employs and interweaves various literary conventions, prompts dialogue between his own works and draws the reader into the very center of his tricks, nuances and simulations. Perec’s writing could be deemed a pure act of dramatization, where the author himself, to some extent, takes on the role of director, making his audience not so much the recipients of his texts but the actors performing them.
The presence of two different infantile Tay-Sachs disease mutations in a Cajun population
Energy Technology Data Exchange (ETDEWEB)
McDowell, G.A.; Blitzer, M.G. (Univ. of Maryland School of Medicine, Baltimore, MD (United States)); Mules, E.H. (Kennedy Krieger Institute, Baltimore, MD (United States)); Fabacher, P. (Office of Public Health, Shreveport, LA (United States)); Shapira, E. (Tulane Univ. of School of Medicine, New Orleans, LA (United States))
1992-11-01
A study was undertaken to characterize the mutation(s) responsible for Tay-Sachs disease (TSD) in a Cajun population in southwest Louisiana and to identify the origins of these mutations. Eleven of 12 infantile TSD alleles examined in six families had the [beta]-hexosaminidase A (Hex A) [alpha]-subunit exon 11 insertion mutation that is present in approximately 70% of Ashkenazi Jewish TSD heterozygotes. The mutation in the remaining allele was a single-base transition in the donor splice site of the [alpha]-subunit intron 9. To determine the origins of these two mutations in the Cajun population, the TSD carrier status was enzymatically determined for 90 members of four of the six families, and extensive pedigrees were constructed for all carriers. A single ancestral couple from France was found to be common to most of the carriers of the exon 11 insertion. Pedigree data suggest that this mutation has been in the Cajun population since its founding over 2 centuries ago and that it may be widely distributed within the population. In contrast, the intron 9 mutation apparently was introduced within the last century and probably is limited to a few Louisiana families. 29 refs., 4 figs.
High school Tay-Sachs disease carrier screening: 5 to 11-year follow-up.
Curd, Helen; Lewis, Sharon; Macciocca, Ivan; Sahhar, Margaret; Petrou, Vicki; Bankier, Agnes; Lieberman, Sari; Levy-Lahad, Ephrat; Delatycki, Martin B
2014-04-01
The Melbourne high school Tay-Sachs disease (TSD) carrier screening program began in 1997. The aim of this study was to assess the outcomes of this screening program among those who had testing more than 5 years ago, to evaluate the long-term impact of screening. A questionnaire was used for data collection and consisted of validated scales and purposively designed questions. Questionnaires were sent to all carriers and two non-carriers for each carrier who were screened in the program between 1999 and 2005. Twenty-four out of 69 (34.8 %) carriers and 30/138 (21.7 %) non-carriers completed the questionnaire. Most participants (82 %) retained good knowledge of TSD and there was no evidence of a difference in knowledge between carriers and non-carriers. Most participants (83 %) were happy with the timing and setting of screening and thought that education and screening for TSD should be offered during high school. There was no difference between carriers and non-carriers in mean scores for the State Trait Anxiety Inventory and Decision Regret Scale. This evaluation indicated that 5-11 years post high school screening, those who were screened are supportive of the program and that negative consequences are rare.
Lew, Raelia M; Burnett, Leslie; Proos, Anné L; Barlow-Stewart, Kristine; Delatycki, Martin B; Bankier, Agnes; Aizenberg, Harry; Field, Michael J; Berman, Yemima; Fleischer, Ronald; Fietz, Michael
2015-03-01
Internationally, Tay-Sachs disease (TSD) preconception screening of Ashkenazi Jewish (AJ) individuals and couples has led to effective primary prevention of TSD. In Australia, adolescent preconception genetic screening programs operate mainly in Jewish community high schools. These existing programs offer an effective means of primary prevention of TSD, are cost effective and safe. However, in the broader Australian community TSD screening is not systematically performed and cases still occur in unscreened AJ individuals. In order to improve the effectiveness of Australian screening, there is a need for definitive guidelines for healthcare professionals to facilitate extension of the proven benefits of preconception TSD screening to all AJ individuals at risk. We performed a systematic review of the relevant literature relating to AJ pre-conception and antenatal screening for TSD. The evidence was assessed using an established National Health and Medical Research Council evidence grading system. Evaluations of efficacy of TSD screening programs design and execution, cost-benefit and cost-utility health economic evaluation, and population outcomes were undertaken. The results have been used to propose a model for universal AJ TSD preconception and antenatal screening for the primary care setting. © 2014 The Authors. Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
International Nuclear Information System (INIS)
Shabbir, Ghulam; Khan, Suhail
2010-01-01
In this paper we classify Kantowski-Sachs and Bianchi type III space-times according to their teleparallel Killing vector fields using direct integration technique. It turns out that the dimension of the teleparallel Killing vector fields are 4 or 6, which are the same in numbers as in general relativity. In case of 4 the teleparallel Killing vector fields are multiple of the corresponding Killing vector fields in general relativity by some function of t. In the case of 6 Killing vector fields the metric functions become constants and the Killing vector fields in this case are exactly the same as in general relativity. Here we also discuss the Lie algebra in each case. (general)
Directory of Open Access Journals (Sweden)
Jean-Baptiste Velut
2010-03-01
Full Text Available Cet article se propose de dresser un bilan critique de la politique commerciale du Président George W. Bush. Dans un premier temps, il compare les perspectives idéologiques et les ambitions politiques du leader républicain à celles de son prédécesseur démocrate, Bill Clinton, avant de mettre l’accent sur les nouvelles données du contexte politique et économique des années 2000. Ces éléments introductifs serviront de fondations, d’une part, pour l’étude de la gestion des relations commerciales entre les États-Unis et leurs principaux partenaires économiques, et d’autre part pour l’analyse de la stratégie de « libéralisation compétitive » adoptée par George W. Bush aux niveaux multilatéral, régional et bilatéral. L’objectif est double : déterminer les lignes de rupture et de continuité entre le président républicain et son prédécesseur ; et établir un bilan des principales initiatives commerciales lancées par l’administration Bush dans le but de mieux comprendre les nouveaux défis intérieurs et internationaux auxquels son successeur sera confronté.This article offers a critical assessment of American trade policy under George W. Bush. It begins by comparing his views and political ambitions with those of his Democratic predecessor, Bill Clinton, before highlighting the new political and economic context of the 2000s. These elements provide crucial background, first to study the evolution of America’s relations with its top trading partners and second to analyze the strategy of “competitive liberalization” undertaken by the administration at the multilateral, regional and bilateral levels. This article has two objectives: 1 determining trends of continuity and change between George W. Bush and his predecessor; 2 assessing the trade policy initiatives undertaken by the Republican administration in order to understand the domestic and international challenges with which the next President
International Nuclear Information System (INIS)
Barcelo, F.; Bechade, J. L.; Fournier, B.
2010-01-01
EBSD measurements were carried out on four different martensitic steels (T91, P92, EM10 and Eurofer) in various metallurgical conditions (nine different microstructural states). The usual orientation relationships (ORs) between the parent austenitic phase and the resulting martensite in martensitic steels are those of Nishiyama-Wassermann (NW) and Kurjumov-Sachs (KS). The present study first proposes a methodology based on the combined analysis of the misorientation distribution, the pole figures (PFs) and the angle/axis pairs. This methodology leads to the conclusion that neither NW nor KS relationships are able to account for all the features observed whatever the material under study. A third OR proposed by Greninger and Troiano (GT) proves to describe the relationship between austenite and ferrite in all four different martensitic steels much more accurately. (authors)
General of the Army George C. Marshall on Operational Leadership
2007-11-06
145 and he actively pursued it as an end itself, even personally getting involved in the distribution of chocolate and cigarettes.146 When a...Marshall to Mrs. Thomas B. Coles, 26 October 1927, Ibid., 316. Marshall was happy to move and looking forward to the new duty. 51 Lecture, Fort
Fort St. Vrain core performance
International Nuclear Information System (INIS)
McEachern, D.W.; Brown, J.R.; Heller, R.A.; Franek, W.J.
1977-07-01
The Fort St. Vrain High Temperature Gas Cooled Reactor core performance has been evaluated during the startup testing phase of the reactor operation. The reactor is graphite moderated, helium cooled, and uses coated particle fuel and on-line flow control to each of the 37 refueling regions. Principal objectives of startup testing were to determine: core and control system reactivity, radial power distribution, flow control capability, and initial fission product release. Information from the core demonstrates that Technical Specifications are being met, performance of the core and fuel is as expected, flow and reactivity control are predictable and simple for the operator to carry out
Third party testing : new pilot facility for mining processes opens in Fort McKay
International Nuclear Information System (INIS)
Jaremko, D.
2007-01-01
Fort McKay lies 65 kilometres north of Fort McMurray, Alberta and is the centre of operational oilsands mining activity. As such, it was chosen for a pilot testing facility created by the Geneva-based SGS Group. The reputable facility provides an opportunity for mining producers to advance their processes, including environmental performance, by allowing them to test different processes on their own oilsands. The Northern Lights partnership, led by Synenco Energy, was the first client at the facility. Due to outsourcing, clients are not obligated to make substantial capital investment into in-house research. The Northern Lights partnership will be using the facility to test extraction processes on bitumen from its leases. Although the Fort McKay facility is SGS's first venture into the oilsands industry, it operates in more than 140 companies globally, including the mineral industry, and specializes in inspection, verification, testing and certification. SGS took the experience from its minerals extraction business to identify what could be done to help the oilsands industry by using best practices developed from global operations. The facility lies on the Fort McKay industrial park owned by the Fort McKay First Nation. An existing testing facility called McMurray Resources Research and Testing was expanded by the SGS Group to include environmental analysis capabilities. The modular units that lie on 6 acres include refrigerated ore storage to maintain ore integrity; modular ore and materials handling systems; extraction equipment; and, zero discharge process water and waste disposal systems. Froth treatment will be added in the near future to cover the entire upstream side of the mining processing business. A micro-upgrader might be added in the future to manufacture synthetic crude. 3 figs
Third party testing : new pilot facility for mining processes opens in Fort McKay
Energy Technology Data Exchange (ETDEWEB)
Jaremko, D.
2007-12-15
Fort McKay lies 65 kilometres north of Fort McMurray, Alberta and is the centre of operational oilsands mining activity. As such, it was chosen for a pilot testing facility created by the Geneva-based SGS Group. The reputable facility provides an opportunity for mining producers to advance their processes, including environmental performance, by allowing them to test different processes on their own oilsands. The Northern Lights partnership, led by Synenco Energy, was the first client at the facility. Due to outsourcing, clients are not obligated to make substantial capital investment into in-house research. The Northern Lights partnership will be using the facility to test extraction processes on bitumen from its leases. Although the Fort McKay facility is SGS's first venture into the oilsands industry, it operates in more than 140 companies globally, including the mineral industry, and specializes in inspection, verification, testing and certification. SGS took the experience from its minerals extraction business to identify what could be done to help the oilsands industry by using best practices developed from global operations. The facility lies on the Fort McKay industrial park owned by the Fort McKay First Nation. An existing testing facility called McMurray Resources Research and Testing was expanded by the SGS Group to include environmental analysis capabilities. The modular units that lie on 6 acres include refrigerated ore storage to maintain ore integrity; modular ore and materials handling systems; extraction equipment; and, zero discharge process water and waste disposal systems. Froth treatment will be added in the near future to cover the entire upstream side of the mining processing business. A micro-upgrader might be added in the future to manufacture synthetic crude. 3 figs.
International Nuclear Information System (INIS)
1991-01-01
Georges Bank, a large, shallow marine bank with important fishery resources and possibly important oil and gas resources, lies east of Massachusetts in the territorial waters of both the United States and Canada. The Department of the Interior has planned since 1974 to lease parts of the north Atlantic outer continental shelf (OCS)--including part of Georges Bank--for oil and gas exploration. As a result of public concern about the environmental impacts of oil and gas production on the U.S. OCS, Congress declared a moratorium on drilling on Georges Bank and an area to the southwest. The report--by the NRC's Committee to Review the Outer Continental Shelf Environmental Studies Program and its panels on physical oceanography, ecology, and socioeconomics--reviews the adequacy of information bearing on the potential environmental impacts of OCS oil and gas activities for the Georges Bank sale area
Rail Outloading Capability Study, Fort Polk, Louisiana,
1977-06-01
regardless of experience, to avoid wasted man -hours. The main problem at Fort Polk is that no blocking and bracing material stockpile exists and no...ti1 hottul only thtrough the 0111crinost hole; to defect within 20 days after it is determined to -tuit Owt ttrtk in tuse. III thle caste of classes 3...wheels, slipping, or similar trak (meh causes. 1 -------------------- (12) " Shelly spots" means a condition 2 ------------------------ % where a thin
2013-12-26
... completion of an inventory of human remains under the control of Fort Bowie National Historic Site, Bowie, AZ....R50000] Notice of Inventory Completion: U.S. Department of the Interior, National Park Service, Fort... completed an inventory of human remains, in consultation with the appropriate Indian tribes or Native...
Areva's challenge for ''Georges Besse 2''
International Nuclear Information System (INIS)
Jemain, A.
2003-01-01
For its future uranium enrichment plant of its Tricastin site (Drome, France), the world nuclear leader Areva has abandoned the gaseous diffusion technique (of French origin) for the centrifugation technique, more economical and modular. This future plant, named 'Georges Besse 2' will require 3 billions of euros of investment and will supply a world market also estimated to 3 billions of euros and shared between Areva, Urenco (UK), Usec (US), Minatom (Russia), JNC (Japan) and CNNC (China). The first batches of enriched uranium will be produced using a thousand of centrifuges by 2007. (J.S.)
DEFF Research Database (Denmark)
Silleborg, Ellen
2004-01-01
karakter. Denne situation giveruoverensstemmelser i de studerendes følelsesliv, og hovedparten af fortællingerne afspejler en i mange henseender konfliktfyldt eksamensgruppeproces. I fortællingernes betydninger ses en loyal men privatiseret etik, hvor ansvarlighed bliver til selvskyld. Alle implicerede...
The Second Administration of George W. Bush and U.S.-Russia Relations
Directory of Open Access Journals (Sweden)
Rybalko Olga
2014-12-01
Full Text Available This article is devoted to the analysis of changes in the U.S.-Russia relationships during the presidency of George W. Bush and to the detection of the origins of these changes. The attention is paid to conceptual foreign policy views of the most influential members of administration. The renewal of staff in U.S. administration was one of the important factors of toughening the Russian course of the American foreign policy. At the beginning of the second presidency of George Bush the ratio of forces in the American Congress changed. Opposition forces received the majority in the Congress. This circumstance became the other reason of change of the U.S.-Russia relationships. The bilateral relations during the specified period were complicated by aspiration of the USA to strengthen the influence on the territories of the Post-Soviet states. It caused discontent of Moscow. At the same time, some aspects of the Russian-Iranian nuclear cooperation caused criticism of Washington. The role of personal diplomacy is noted as a factor of forming bilateral relations. During the second term of the presidency of George W. Bush this factor didn't lose its value in comparison with the first term. The article gives the assessment of work of the Bush’s second administration at the Russian direction. The author notes the American focus on the strategy of “selective partnership” with Russia. The conclusion is drawn on George Bush's aspiration to preservation of balance in the U.S.-Russia relations under the conditions of increasing strains.
Fonsén, Tuomo, 1976-
2006-01-01
Autori dissertatsioonist, mis tutvustab Justus Georg Schotteliuse ladinakeelset allegoorilist saksa keele grammatikat ja keeleajalugu käsitlevat tööd 17. sajandist. Schottelius, Justus Georg. Horrendum Bellum Grammaticale Teutonum antiquissimorum [...]. Braunschweig : [s.n.], 1673
George W. Bush in Political Time: The Janus Presidency
Magliocca, G.N.
2009-01-01
This essay places George W. Bush's presidency and the Bush administration in some historical context by applying the model of “political time” developed in recent books by Stephen Skowronek (2008) and Keith Whittington (2007). My thesis is that Bush's political failure during his second term was
George Herbert Mead, Um, osoba i društvo
Bačeković, Alica
2004-01-01
Prikaz knjige George Herbert Mead, Um, osoba i društvo sa stajališta socijalnog biheviorista, priredio i uvod napisao Charles W. Morris, s engleskoga preveo Srđan Dvornik, Naklada Jesenski i Turk, Hrvatsko sociološko društvo, Zagreb 2003, xxx + 392 str
Prescient … and Not Always Accounted For: The Wisdom and Foresight of George A. Roeper
Delisle, Jim; Ruff, Marcia
2016-01-01
When George A. Roeper enlisted the aid of Dr. A. Harry Passow and other leaders in the field to help George convert his Michigan independent school to focus on gifted children in 1956, there was only one other elementary school in the country at the time devoted exclusively to gifted child education. Though his wife and school cofounder,…
Bedrosian, Paul A.; Ball, Lyndsay B.; Bloss, Benjamin R.; Buesch, David C.
2014-01-01
From December 2010 to January 2011, the U.S. Geological Survey conducted airborne electromagnetic and magnetic surveys of Leach Lake Basin within the National Training Center, Fort Irwin, California. These data were collected to characterize the subsurface and provide information needed to understand and manage groundwater resources within Fort Irwin. A resistivity stratigraphy was developed using ground-based time-domain electromagnetic soundings together with laboratory resistivity measurements on hand samples and borehole geophysical logs from nearby basins. This report releases data associated with the airborne surveys, as well as resistivity cross-sections and depth slices derived from inversion of the airborne electromagnetic data. The resulting resistivity models confirm and add to the geologic framework, constrain the hydrostratigraphy and the depth to basement, and reveal the distribution of faults and folds within the basin.
2012-06-21
...-AA00 Eighth Coast Guard District Annual Safety Zones; Sound of Independence; Santa Rosa Sound; Fort... Coast Guard will enforce a Safety Zone for the Sound of Independence event in the Santa Rosa Sound, Fort... during the Sound of Independence. During the enforcement period, entry into, transiting or anchoring in...
Forest pathology and entomology at Fort Valley Experimental Forest
Brian W. Geils
2008-01-01
Forest pathology and entomology have been researched at Fort Valley Experimental Forest throughout its history. The pathogens and insects of particular interest are mistletoes, decay and canker fungi, rusts, bark beetles, and various defoliators. Studies on life history, biotic interactions, impacts, and control have been published and incorporated into silvicultural...
Stochastic programming the state of the art in honor of George B. Dantzig
2011-01-01
From the Preface… The preparation of this book started in 2004, when George B. Dantzig and I, following a long-standing invitation by Fred Hillier to contribute a volume to his International Series in Operations Research and Management Science, decided finally to go ahead with editing a volume on stochastic programming. The field of stochastic programming (also referred to as optimization under uncertainty or planning under uncertainty) had advanced significantly in the last two decades, both theoretically and in practice. George Dantzig and I felt that it would be valuable to showcase some of these advances and to present what one might call the state-of- the-art of the field to a broader audience. We invited researchers whom we considered to be leading experts in various specialties of the field, including a few representatives of promising developments in the making, to write a chapter for the volume. Unfortunately, to the great loss of all of us, George Dantzig passed away on May 13, 2005. Encouraged by...
The conceptualization of love in religious thought of George Florovsky and Michael Pomazansky
Directory of Open Access Journals (Sweden)
Pavenkov Oleg Vladimirovich
2015-04-01
Full Text Available The present article is concerned with the question of conceptualization of love in works of Fr. George Florovsky and Fr. Michael Pomazansky, Russian religious thinkers and theologists. We are studying the meaning and appropriacy of two words, ‘love’ (English and ‘любовь’ (Russian, that are the best to represent the agapelogical positive evaluation in Russian religious thought. Data for study was taken from ten different articles and extracts from books written by Fr. George Florovsky and Fr. Michael Pomazansky. On the basis of this analysis we develop semantic explications of words ‘love’ and ‘любовь’ as Christian spiritual concepts within the framework of theoretical approach of Natural Semantic Metalanguage (NSM. In summary we state that this article discusses, describes and determines some similarities and differences in understanding of concept ‘love’ in the affore-referenced works by Fr. George Florovsky and Fr. Michael Pomazansky.
Rountree, J S Shane; Butters, Terry D; Wormald, Mark R; Boomkamp, Stephanie D; Dwek, Raymond A; Asano, Naoki; Ikeda, Kyoko; Evinson, Emma L; Nash, Robert J; Fleet, George W J
2009-03-01
N-Acetylhexosaminidases are of considerable importance in mammals and are involved in various significant biological processes. In humans, deficiencies of these enzymes in the lysosome, resulting from inherited genetic defects, cause the glycolipid storage disorders Tay-Sachs and Sandhoff diseases. One promising therapy for these diseases involves the use of beta-N-acetylhexosaminidase inhibitors as chemical chaperones to enhance the enzyme activity above sub-critical levels. Herein we describe the synthesis and biological evaluation of a potent inhibitor, 2-acetamido-1,4-imino-1,2,4-trideoxy-L-arabinitol (LABNAc), in a high-yielding 11-step procedure from D-lyxonolactone. The N-benzyl and N-butyl analogues were also prepared and found to be potent inhibitors. The enantiomers DABNAc and NBn-DABNAc were synthesised from L-lyxonolactone, and were also evaluated. The L-iminosugar LABNAc and its derivatives were found to be potent noncompetitive inhibitors of some beta-N-acetylhexosaminidases, while the D-iminosugar DABNAc and its derivatives were found to be weaker competitive inhibitors. These results support previous work postulating that D-iminosugar mimics inhibit D-glycohydrolases competitively, and that their corresponding L-enantiomers show noncompetitive inhibition of these enzymes. Molecular modelling studies confirm that the spatial organisation in enantiomeric inhibitors leads to a different overlay with the monosaccharide substrate. Initial cell-based studies suggest that NBn-LABNAc can act as a chemical chaperone to enhance the deficient enzyme's activity to levels that may cause a positive pharmacological effect. LABNAc, NBn-LABNAc, and NBu-LABNAc are potent and selective inhibitors of beta-N-acetylhexosaminidase and may be useful as therapeutic agents for treating adult Tay-Sachs and Sandhoff diseases.
Martino, S; Marconi, P; Tancini, B; Dolcetta, D; De Angelis, M G Cusella; Montanucci, P; Bregola, G; Sandhoff, K; Bordignon, C; Emiliani, C; Manservigi, R; Orlacchio, A
2005-08-01
Therapy for neurodegenerative lysosomal Tay-Sachs (TS) disease requires active hexosaminidase (Hex) A production in the central nervous system and an efficient therapeutic approach that can act faster than human disease progression. We combined the efficacy of a non-replicating Herpes simplex vector encoding for the Hex A alpha-subunit (HSV-T0alphaHex) and the anatomic structure of the brain internal capsule to distribute the missing enzyme optimally. With this gene transfer strategy, for the first time, we re-established the Hex A activity and totally removed the GM2 ganglioside storage in both injected and controlateral hemispheres, in the cerebellum and spinal cord of TS animal model in the span of one month's treatment. In our studies, no adverse effects were observed due to the viral vector, injection site or gene expression and on the basis of these results, we feel confident that the same approach could be applied to similar diseases involving an enzyme defect.
Bioequivalence of fixed-dose combination Myrin®-P Forte and reference drugs in loose combination.
Wang, H F; Wang, R; O'Gorman, M; Crownover, P; Naqvi, A; Jafri, I
2013-12-01
Myrin®-P Forte is a fixed-dose combination (FDC) tablet containing rifampicin (RMP, 150 mg), isoniazid (INH, 75 mg), ethambutol (EMB) hydrochloride (275 mg) and pyrazinamide (PZA, 400 mg) developed for the treatment of tuberculosis (TB). This study was conducted at a single centre--the Pfizer Clinical Research Unit in Singapore. To demonstrate the bioequivalence of each drug component of the Myrin-P Forte FDC and the individual product in loose combination. In a randomized, open-label, single-dose, two-way, crossover study, subjects received single doses of Myrin-P Forte or four individual products under fasting conditions in a crossover fashion with at least 7 days washout between doses. The primary measures for comparison were peak plasma concentration (C(max)) and the area under plasma concentration-time curve (AUC). Of 36 subjects enrolled, 35 completed the study. The adjusted geometric mean ratios and 90% confidence intervals for C(max) and AUC values were completely contained within bioequivalence limits (80%, 125%) for all four drugs in both formulations. Both treatments were generally well tolerated in the study. The Myrin-P Forte FDC tablet formulation is bioequivalent to the four single-drug references for RMP, INH, EMB hydrochloride and PZA at equivalent doses.
International Nuclear Information System (INIS)
Burnette, R.D.; Baldwin, N.L.
1980-11-01
The chemical impurities in the primary coolants of the Peach Bottom and Fort St. Vrain reactors are discussed. The impurity mixtures in the two plants were quite different because the sources of the impurities were different. In the Peach Bottom reactor, the impurities were dominated by H 2 and CH 4 , which are decomposition products of oil. In the Fort St. Vrain reactor, there were high levels of CO, CO 2 , and H 2 O. Although oil ingress at Peach Bottom created carbon deposits on virtually all surfaces, its effect on reactor operation was negligible. Slow outgassing of water from the thermal insulation at Fort St. Vrain caused delays in reactor startup. The overall graphite oxidation in both plants was negligible
International Nuclear Information System (INIS)
Burnette, R.D.; Baldwin, N.L.
1981-01-01
The chemical impurities in the primary coolants of the Peach Bottom and Fort St. Vrain reactors are discussed. The impurity mixtures in the two plants were quite different because the sources of the impurities were different. In the Peach Bottom reactor, the impurities were dominated by H 2 and CH 4 , which are decomposition products of oil. In the Fort St. Vrain reactor, there were high levels of CO, CO 2 , and H 2 O. Although oil ingress at Peach Bottom created carbon deposits on virtually all surfaces, its effect on reactor operation was negligible. Slow outgassing of water from the thermal insulation at Fort St. Vrain caused delays in reactor startup. The overall graphite oxidation in both plants was negligible. (author)
Festschrift Charpak (Georges) on his 65th birthday
Lehmann, Pierre; Rubbia, Carlo; Saudinos, Jean; CERN. Geneva
1989-01-01
On the occasion of the 65th birthday of Georges Charpak and of his retirement, the Director-General and the EP Division invite you to a symposium in his h. Chairman : P. Lehmann. - Opening address : C. Rubbia. - Message from V. Weisskopf. - L. Lederman : Superstrings needs sealing wax. - J. Saudinos : Quelques applications des detecteurs gazeux a la medecine et a la biologie.
Renewable Energy Opportunities at Fort Hood, Texas
Energy Technology Data Exchange (ETDEWEB)
Chvala, William D.; Warwick, William M.; Dixon, Douglas R.; Solana, Amy E.; Weimar, Mark R.; States, Jennifer C.; Reilly, Raymond W.
2008-06-30
The document provides an overview of renewable resource potential at Fort Hood based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. The effort was funded by the U.S. Army Installation Management Command (IMCOM) as follow-on to the 2005 DoD Renewables Assessment. This effort focuses on grid-connected generation of electricity from renewable energy sources and also ground source heat pumps for heating and cooling buildings, as directed by IMCOM.
Tuning the Self : George Herbert's poetry as cognitive behaviour
van Es, Eelco
2013-01-01
This book provides a cognitive analysis of the poetry of George Herbert (1593- 1633). From Herbert’s own thinking, recorded in his prose treatises, can be deduced that his poems should serve a specific function: teaching self-knowledge to his readers. Self-knowledge is a necessary skill, to be
Calculation of Void in the Fort Saint Vrain Material
Energy Technology Data Exchange (ETDEWEB)
Potter, David Charles [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Taylor, Craig Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Coons, James Elmer [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2017-05-11
The percent void of the Fort Saint Vrain (FSV) material is estimated to be 21.1% based on the volume of the gap at the top of the drums, the volume of the coolant channels in the FSV fuel element, and the volume of the fuel handling channel in the FSV fuel element.
Yuretich, Richard F.; Batchelder, Gail L.
1988-01-01
The Fort River watershed in central Massachusetts receives precipitation with a composition similar to that in Hubbard Brook (New Hampshire), yet the average stream water chemistry is substantially different, showing higher pH and TDS. This is largely a function of bedrock and surficial geology, and chemical differences among small streams within the Fort River watershed are apparently controlled by the composition and thickness of the prevailing surficial cover. The surficial deposits determine groundwater and surface water flow paths, thereby affecting the resultant contact time with mineral matter and the chemistry of the runoff. Despite the rural setting, over 95% of the annual sodium and chloride in the streams comes from road salt; after correcting for this factor, cation denudation rates are about equal to those at Hubbard Brook. However, silica removal is occurring at a rate more than 30% greater in the Fort River. When climatic conditions in Hubbard Brook and Fort River are normalized, weathering rates appear consistently higher in the Fort River, reflecting differences in weathering processes (i.e., cation exchange and silicate breakdown) and hydrogeology. Because of uncertainties in mechanisms of cation removal from watersheds, the silica denudation rate may be a better index of weathering intensity.
Sustainability Analysis of the Water Resources and Supply of the Vieux Fort Region of Saint Lucia
Coles, D.; Johnson, B.; Morgan, F.
2005-05-01
In the Vieux Fort region of the Caribbean island of St. Lucia, water needs are becoming acute. The water supply shortfalls during the dry season will continue to grow as population and development increase, unless action is taken. Actions to address the problem should include measures to optimize the present water delivery system and the development of a new supply, through new intakes, groundwater, or reservoir construction. An investigation into the potential for groundwater resources using electrical resistivity soundings indicated a likely pervasive, shallow aquitard of clay materials below the water table; the shallowness of this aquitard virtually precludes the existence of productive perched aquifers. Consequently, a model of Grande Riviere du Vieux Fort (Big Vieux Fort River) seasonal surface-water flow was developed, based on a digital elevation model and rainfall data, allowing us to analyze the possible productivity of any new intakes placed along the river. A specific site downstream of the present intake was recommended for potential development. Recommendations were given for short, medium and long-term development of the resources and supply of the Vieux Fort region of southern St. Lucia.
Energy efficiency campaign for residential housing at the Fort Lewis army installation
Energy Technology Data Exchange (ETDEWEB)
AH McMakin; RE Lundgren; EL Malone
2000-02-23
In FY1999, Pacific Northwest National Laboratory conducted an energy efficiency campaign for residential housing at the Fort Lewis Army Installation near Tacoma, Washington. Preliminary weather-corrected calculations show energy savings of 10{percent} from FY98 for energy use in family housing. This exceeded the project's goal of 3{percent}. The work was funded by the U.S. DOEs Federal Energy Management Program (FEMP), Office of Energy Efficiency and Renewable Energy. The project adapted FEMP's national ``You Have the Power Campaign'' at the local level, tailoring it to the military culture. The applied research project was designed to demonstrate the feasibility of tailored, research-based strategies to promote energy conservation in military family housing. In contrast to many energy efficiency efforts, the campaign focused entirely on actions residents could take in their own homes, as opposed to technology or housing upgrades. Behavioral change was targeted because residents do not pay their own utility bills; thus other motivations must drive personal energy conservation. This campaign augments ongoing energy savings from housing upgrades carried out by Fort Lewis. The campaign ran from September 1998 through August 1999. The campaign strategy was developed based on findings from previous research and on input from residents and officials at Fort Lewis. Energy use, corrected to account for weather differences, was compared with the previous year's use. Survey responses from 377 of Fort Lewis residents of occupied housing showed that the campaign was moderately effective in promoting behavior change. Of those who were aware of the campaign, almost all said they were now doing one or more energy-efficient things that they had not done before. Most people were motivated by the desire to do the right thing and to set a good example for their children. They were less motivated by other factors.
Master Environmental Plan: Fort Wingate Depot Activity, Gallup, New Mexico
Energy Technology Data Exchange (ETDEWEB)
Biang, C.A.; Yuen, C.R.; Biang, R.P.; Antonopoulos, A.A.; Ditmars, J.D.
1990-12-01
The master environmental plan is based on an environmental assessment of the areas requiring environmental evaluation (AREEs) at Fort Wingate Depot Activity near Gallup, New Mexico. The Fort Wingate Depot Activity is slated for closure under the Base Closure and Realignment Act, Public Law 100--526. The MEP assesses the current status, describes additional data requirements, recommends actions for the sites, and establishes a priority order for actions. The plan was developed so that actions comply with hazardous waste and water quality regulations of the State of New Mexico and applicable federal regulations. It contains a brief history of the site, relevant geological and hydrological information, and a description of the current status for each AREE along with a discussion of the available site-specific data that pertain to existing or potential contamination and the impact on the environment. 35 refs., 27 figs., 23 tabs.
Georges Lema\\^itre: Life, Science and Legacy
Mitton, Simon
2016-01-01
This paper celebrates the remarkable life, science and legacy of Abb\\'e Georges Lema\\^itre, the Belgian cleric and professor of physics; he was the architect of the fireworks model for the origin of the universe. He died half a century ago, three days after learning that Arno Penzias and Robert Wilson had discovered the cosmic microwave background. Despite being gravely ill from leukaemia, Lema\\^itre lucidly praised this news, which confirmed the explosive genesis of our universe.
Assessment of DOD Wounded Warrior Matters -- Fort Drum
2011-09-30
their relation to military duties. The six factors that are evaluated are: physical capacity or stamina , upper extremities, lower extremities...Health Net Federal Services contractor. The Fort Drum MEDDAC Referral Management Office created a “Reports Cell ” which was responsible for obtaining...Care Division had created a CLR/Reports Cell group that focused specifically on obtaining CLRs, inputting them into patients’ AHLTA records and
Thunderstorm and Lightning Studies using the FORTE Optical Lightning System (FORTE/OLS)
International Nuclear Information System (INIS)
Argo, P.; Franz, R.; Green, J.; Guillen, J.L.; Jacobson, A.R.; Kirkland, M.; Knox, S.; Spalding, R.; Suszcynsky, D.M.
1999-01-01
Preliminary observations of simultaneous RF and optical emissions from lightning as seen by the FORTE spacecraft are presented. RF/optical pairs of waveforms are routinely collected both as individual lightning events and as sequences of events associated with cloud-to-ground (CG) and intra-cloud (IC) flashes. CG pulses can be distinguished from IC pulses based on the properties of the RF and optical waveforms, but mostly based on the associated RF spectrograms. The RF spectrograms are very similar to previous ground-based VHF observations of lightning and show signatures associated with return strokes, stepped and dart leaders, and attachment processes,. RF emissions are observed to precede the arrival of optical emissions at the satellite by a mean value of 280 microseconds. The dual phenomenology nature of these observations are discussed in terms of their ability to contribute to a satellite-based lightning monitoring mission
Thunderstorm and Lightning Studies using the FORTE Optical Lightning System (FORTE/OLS)
Energy Technology Data Exchange (ETDEWEB)
Argo, P.; Franz, R.; Green, J.; Guillen, J.L.; Jacobson, A.R.; Kirkland, M.; Knox, S.; Spalding, R.; Suszcynsky, D.M.
1999-02-01
Preliminary observations of simultaneous RF and optical emissions from lightning as seen by the FORTE spacecraft are presented. RF/optical pairs of waveforms are routinely collected both as individual lightning events and as sequences of events associated with cloud-to-ground (CG) and intra-cloud (IC) flashes. CG pulses can be distinguished from IC pulses based on the properties of the RF and optical waveforms, but mostly based on the associated RF spectrograms. The RF spectrograms are very similar to previous ground-based VHF observations of lightning and show signatures associated with return strokes, stepped and dart leaders, and attachment processes,. RF emissions are observed to precede the arrival of optical emissions at the satellite by a mean value of 280 microseconds. The dual phenomenology nature of these observations are discussed in terms of their ability to contribute to a satellite-based lightning monitoring mission.
Final Sampling and Analysis Plan for Background Sampling, Fort Sheridan, Illinois
National Research Council Canada - National Science Library
1995-01-01
.... This Background Sampling and Analysis Plan (BSAP) is designed to address this issue through the collection of additional background samples at Fort Sheridan to support the statistical analysis and the Baseline Risk Assessment (BRA...
Serial CT scans and MRI scans of Tay-Sachs disease
International Nuclear Information System (INIS)
Shimoizumi, Hideo; Miyao, Masutomo; Ichihashi, Koh; Sawa, Rituko; Yamamoto, Yoshifumi; Tanaka, Osamu; Yanagisawa, Masayoshi; Kamoshita, Shigehiko.
1986-01-01
Serial X-ray CT and MRI were performed on 2 cases of Tay-Sachs disease. Case 1 : a 3-year-10-month-old girl. Her developmental milestones were normal until the age of 6 months. At the age of 10 months, hypotonia and unduly sensitiveness to sounds were noticed. She had cherry red spots in both fundi, and the serum hexosaminidase A activity was low. Significant clinical features during the next 3 years included regression of developmental milestones to the level of one month, and myoclonic and generalised seizures. After 3 years she showed megalencephaly, unstable body temperature, and respiratory disorders. Case 2 : a 2-year-6-month-old boy. His developmental milestones were normal until the age of 5 months. Then he manifested hyperreaction to noises and further developments ceased. He started to deteriorate from the age of 1 year and 2 months, and had no head control at the age of 1 year and 6 months. Cherry red spots were detected and the serum hexsosaminidase A activity was low, too. X-ray CT at the early stage of cases 1 and 2 showed mild cerebral atrophy and high density areas in bilateral thalami and basal ganglia. At the late stage of Case 1, high density areas appeared in occipital and frontal white matters. MRI in both patients were strikingly similar. In their grey matters, linear light areas were demonstrated on IR images. Their white matters showed extensive dark (long T 1 ) areas on IR images, and extensive light (long T 2 ) areas on SE images. Bilateral thalami and basal ganglia were light on IR images and dark on SE images. The findings of MRI in our patients seemed to correlate well with pathological and biochemical changes in their brains. (author)
George de Hevesy (1885 - 1966), founder of radioanalytical chemistry
International Nuclear Information System (INIS)
Niese, S.
2006-01-01
George de Hevesy has founded Radioanalytical Chemistry and Nuclear Medicine, discovered the element hafnium and first separated stable isotopes. For all these different important achievements he was nominated for the Nobel Prize. On occasion of his discovery of activation analysis 70 years ago his life and work will be illustrated. (author)
International Nuclear Information System (INIS)
Tomida, T.; Wakita, M.; Yasuyama, M.; Sugaya, S.; Tomota, Y.; Vogel, S.C.
2013-01-01
The phenomenon that the transformation texture near the initial texture reproduces after the phase transformation cycle such as ferrite (α, body-centered cubic) → austenite (γ, face-centered cubic) → α is called a texture memory. In this study, the texture change in a 0.1% C–1% Mn hot-rolled steel sheet during the α → γ → α transformation cycle was studied via neutron diffraction and the transformation texture prediction based on a variant selection rule that we call the double Kurdjumov–Sachs (K–S) relation. The texture change observed by neutron diffraction, which clearly showed the texture memory, could be quantitatively reproduced by the proposed variant selection rule adopted into the calculation method based on the spherical harmonics expansion of orientation distribution functions. Therefore, it is most likely that the texture memory in steel is caused by the preferential selection of those K–S variants that reduce the interfacial energy between a precipitate and two adjoining parent phase grains at the same time, which we call the double K–S relation
George Smoot, Blackbody, and Anisotropy of the Cosmic Microwave Background
the Cosmic Microwave Background Radiation Resources with Additional Information * Videos 'George Smoot anisotropy of the cosmic microwave background radiation." '1 Smoot previously won the Ernest Orlando . Smoot, blackbody, and anisotropy of the Cosmic Microwave Background (CMB) radiation is available in full
2010-06-03
... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Rescinding the Notice of Intent for an Environmental Impact Statement: Prince George's County, MD AGENCY: Federal Highway Administration. ACTION... Statement that was issued on June 11, 2008, for a proposed roadway improvement project in Prince George's...
Strategic Energy Management Plan For Fort Buchanan, Puerto Rico
Energy Technology Data Exchange (ETDEWEB)
Parker, Steven A.; Hunt, W. D.
2001-10-31
This document reports findings and recommendations as a result of a design assistance project with Fort Buchanan with the goals of developing a Strategic Energy Management Plan for the Site. A strategy has been developed with three major elements in mind: 1) development of a strong foundation from which to build, 2) understanding technologies that are available, and 3) exploring financing options to fund the implementation of improvements. The objective of this report is to outline a strategy that can be used by Fort Buchanan to further establish an effective energy management program. Once a strategy is accepted, the next step is to take action. Some of the strategies defined in this Plan may be implemented directly. Other strategies may require the development of a more sophisticated tactical, or operational, plan to detail a roadmap that will lead to successful realization of the goal. Similarly, some strategies are not single events. Rather, some strategies will require continuous efforts to maintain diligence or to change the culture of the Base occupants and their efforts to conserve energy resources.
1993-07-01
rod system or through a tremie tube ; both procedures were used interchangeably at Fort Dix to demon- strate the efficiency and effectiveness of each...allows delivery through either a l/4-in.-diam grout tube or a 3/8-in.-diam rout tube . The grout used at Fort Dix consisted of a mixture of water and... microfine , blended Portland cement (Lehigh Geocem’, Leeds, Alabama). The grout is a suspension of a uniformly produced cement clinker interground with
On Some Philosophical Aspects of the Background to Georg Cantor’s theory of sets
Tapp, Christian
2011-01-01
Georg Cantor a cherché à assurer les fondements de sa théorie des ensembles. Cet article présente les differentiations cantoriennes concernant la notion d’infinité et une perspective historique de l’émergence de sa notion d’ensemble. Georg Cantor sought secure foundations for his set theory. This article presents an account of Cantor’s differentiations concerning the notion of infinity and a tentative historical parsepctive on his notion of set.
GÜNEY, Zekeriya; KORKMAZ, Nebiye
2014-01-01
Özet Georg Cantor, kümeler kuramı ve matematiksel biçimciliğin öncüsüdür. Cantor’un özellikle sonsuzluklarla ilgili çalışmaları matematikte devrim niteliğindedir ve başta topoloji olmak üzere matematiğin çeşitli alanlarında önemli gelişmelere yol açmıştır. Cantor Kuramı’nın pür matematiksel karakteri, matematiğe ve matematik eğitimine yeni bir bakış açısı getirmiş ve matematiğin asıl eğitimsel öneminin, bir zihin jimnastiği olmasından geldiği daha iyi anlaşılır olmuştur. Matematiğin, herhang...
Directory of Open Access Journals (Sweden)
Alejandro Peña-Arroyave
2016-01-01
Full Text Available Resumen: Se identificaron algunos aspectos determinantes de la obra poética de Georg Trakl, tomando como punto de partida la conciencia del escritor acerca de la muerte de Dios, desde la perspectiva de Nietzsche. Se hizo un énfasis sobre la melancolía, soporte de la creación, testimonio y reconocimiento del errar y el duelo del hombre, a partir de la cual el autor pudo expresar el desconsuelo por la ruina y el ocaso de Occidente.
Fort Lewis natural gas and fuel oil energy baseline and efficiency resource assessment
International Nuclear Information System (INIS)
Brodrick, J.R.; Daellenbach, K.K.; Parker, G.B.; Richman, E.E.; Secrest, T.J.; Shankle, S.A.
1993-02-01
The mission of the US Department of Energy (DOE) Federal Energy Management Program (FEMP) is to lead the improvement of energy efficiency and fuel flexibility within the federal sector. Through the Pacific Northwest Laboratory (PNL), FEMP is developing a fuel-neutral approach for identifying, evaluating, and acquiring all cost-effective energy projects at federal installations; this procedure is entitled the Federal Energy Decision Screening (FEDS) system. Through a cooperative program between FEMP and the Army Forces Command (FORSCOM) for providing technical assistance to FORSCOM installations, PNL has been working with the Fort Lewis Army installation to develop the FEDS procedure. The natural gas and fuel oil assessment contained in this report was preceded with an assessment of electric energy usage that was used to implement a cofunded program between Fort Lewis and Tacoma Public Utilities to improve the efficiency of the Fort's electric-energy-using systems. This report extends the assessment procedure to the systems using natural gas and fuel oil to provide a baseline of consumption and an estimate of the energy-efficiency potential that exists for these two fuel types at Fort Lewis. The baseline is essential to segment the end uses that are targets for broad-based efficiency improvement programs. The estimated fossil-fuel efficiency resources are estimates of the available quantities of conservation for natural gas, fuel oils number-sign 2 and number-sign 6, and fuel-switching opportunities by level of cost-effectiveness. The intent of the baseline and efficiency resource estimates is to identify the major efficiency resource opportunities and not to identify all possible opportunities; however, areas of additional opportunity are noted to encourage further effort
2012-07-03
...-202-2783, (Formerly: Forensic Toxicology Laboratory Baptist Medical Center) Clinical Reference Lab... Minneapolis Veterans Affairs Medical Center, Forensic Toxicology Laboratory, 1 Veterans Drive, Minneapolis, MN... 65203, 573-882-1273 U.S. Army Forensic Toxicology Drug Testing Laboratory, 2490 Wilson St., Fort George...
2009-07-20
and Obstetrics /Gynecology. Inpatient care includes Obstetrics , Intensive Care, and Post Anesthesia Care/Same Day Surgery. EACH Mission: Delivering...charged with murder in Iraq shooting deaths, 2009). EACH Inpt Psych 13 Fort Carson has not been immune to the increase in suicides and violence among...to identify Soldiers with PTSD symptoms. In 2008, however, attention returned to Fort Carson as a number of local homicides and other violence tied
Leaktightness in HTGRs - experience at Fort St. Vrain
International Nuclear Information System (INIS)
Neylan, A.J.; Barker, R.A.; Deardorff, A.F.
1976-01-01
The Fort St. Vrain Prestressed Concrete Reactor Vessel is the first utilized to contain the helium coolant of a High Temperature Gas-Cooled Reactor. Because the helium coolant contains fission products, leakage from the vessel is limited to 15 percent of vessel inventory per year. This paper describes the fabrication methods and development tests used to assure this leaktightness and the leakage test conducted to verify it. (author)
The health of loblolly pine stands at Fort Benning, GA
Soung-Ryoul Ryu; G. Geoff Wang; Joan L. Walker
2013-01-01
Approximately two-thirds of the red-cockaded woodpecker (Picoides borealis) (RCW) groups at Fort Benning, GA, depend on loblolly pine (Pinus taeda) stands for nesting or foraging. However, loblolly pine stands are suspected to decline. Forest managers want to replace loblolly pine with longleaf pine (P. palustris...
2012-09-17
... Landmark and Museum, U.S. Army Fires Center of Excellence, Fort Sill, OK 73503, telephone (580) 442-6570... trapping, 3 metal rings, 2 metal rivets, 17 metal nails, 53 metal bracelets, 1 metal pail, 1,500 glass... A. Neel, Director, Fort Sill National Historic Landmark and Museum, U.S. Army Fires Center of...
GEORG BRANDES AND THE MODERN PROJECT
Directory of Open Access Journals (Sweden)
Jørgen Veisland
2011-01-01
Full Text Available Georg Brandes’ lecture series on The Main Tendencies in 19th Century Literature was initiated in 1871 and consists of a number of innovative interpretations of European literature. Brandes’ interpretations exemplify his interest in the ideals of the Enlightenment: knowledge, liberation, progress and free thought. The lecture series traces a dialectical movement in European literature, described by Brandes as a dialectics between revolution and liberalism on one hand and conservatism and reactionary tendencies on the other. Brandes includes a dialectics between home, i.e. Danishness, and the ‘foreign’; he opens up a dialogue between nationalism and internationalism with the intention of almost literally placing Europe in Denmark and vice versa. The future was going to be realized in the present. Georg Brandes tried to persuade the young writers of Scandinavia to adopt liberalism and naturalism in their novels and dramas, which some of them proceeded to do, convinced as they were that Brandes’ ideas regarding a new ‘debate’, moral and political, in literature, were right. However, they failed to implement these ideas as we can see by a reading of, for example, Jens Peter Jacobsen’s Niels Lyhne (1880; Henrik Ibsen’s Rosmersholm (1886 and Henrik Pontoppidan’s Lykke-Per (1898–1904. Emanicipating the mind and liberating oneself from the reactionary forces of society turned out to be too difficult for the women and men of what Brandes himself referred to as The Modern Breakthrough. Looking at Brandes today we may conclude that he was ahead of his own time as well as ahead of ours. His ideas regarding a new internationalism and liberalism are far from being realized.
Informal report on measurements of slant TEC by FORTE
International Nuclear Information System (INIS)
Massey, R.S.
1997-01-01
Los Alamos National Laboratory's Space and Atmospheric Sciences group is now operating the FORTE satellite, which has two sets of instruments: optical detectors and radio detectors. In this report the author describes work with one set of radio detectors that allow measurements of the total electron content (TEC) traversed by VHF radiation originating at an electromagnetic pulse (EMP) generator located at Los Alamos
Assessment of DoD Wounded Warrior Matters -- Fort Riley
2013-08-06
acceptable excuses included At Remote Care, Regular Leave, Maternity and Paternity Leave, Terminal Leave, Permanent Change of Station, and Transferred to...risk of negative medication interactions and reactions for Soldiers assigned to the Fort Riley WTB. B.2. Background The Joint Commission, an...reconciliation is to minimize medication errors such as omissions, duplications, dosing errors, and drug interactions . Medical reconciliation should
Tile forts of the Liesbeeck Frontier | Sleigh | Scientia Militaria: South ...
African Journals Online (AJOL)
Scientia Militaria: South African Journal of Military Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 27 (1997) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Tile forts of the Liesbeeck Frontier.
77 FR 24579 - Establishment of the Fort Ord National Monument
2012-04-25
... 1775-1776, Anza established the first overland route from ``New Spain,'' as Mexico was then known, to..., approximately 6 miles of which pass through the Fort Ord area. Although much of the historic route currently... tourists and recreationalists from near and far, and enhance its unique natural resources, for the...
The Forte Kreis : an Attempt to Spiritual Leadership over Europe
Poorthuis, Marcel
2017-01-01
Just before the outbreak of World War 1, a group of writers, artists and philosophers decided to establish a spiritual rule over Europe, the Forte Kreis. The group aimed at a reconciliation in Europe, by establishing pacifism, but also between East and West by creating a new language. Their thoughts
St. George at Prague Castle and Perseus: an Impossible Encounter?
Czech Academy of Sciences Publication Activity Database
Bažant, Jan
2015-01-01
Roč. 19, 1/2 (2015), s. 189-201 ISSN 1212-5865 Institutional support: RVO:67985955 Keywords : Bellerophon * St. George * iconography * Prague Castle * classical tradition Subject RIV: AB - History http://studiahercynia.ff.cuni.cz/wp-content/uploads/sites/79/2016/05/jan_bazant_189-201.pdf
Kurt Alfred Georg Mendelssohn 7 January 1906 - 18 September 1980
International Nuclear Information System (INIS)
Shoenberg, D.
1983-01-01
The life, career and main themes of scientific achievement of Kurt Alfred Georg Mendelssohn are described in detail under the headings: early life in Germany, scientific work, early work in Germany, superconductivity, transport properties of metals, liquid helium, medical physics, Oxford and later life. (U.K.)
Haghighi, Alireza; Masri, Amira; Kornreich, Ruth; Desnick, Robert J
2011-12-01
Tay-Sachs disease (TSD), a pan-ethnic, autosomal recessive, neurodegenerative, lysosomal disease, results from deficient β-hexosaminidase A activity due to β-hexosaminidase α-subunit (HEXA) mutations. Prenatal/premarital carrier screening programs in the Ashkenazi Jewish community have markedly reduced disease occurrence. We report the first Jordanian Arab TSD patient diagnosed by deficient β-hexosaminidase A activity. HEXA mutation analysis revealed homozygosity for a nonsense mutation, c.78G>A (p.W26X). Previously reported in Arab patients, this mutation is a candidate for TSD screening in Arab populations. Copyright © 2011 Elsevier Inc. All rights reserved.
Festschrift Charpak (Georges) on his 65th birthday
Saudinos, Jean; Garwin, Richard L; Uggerhøj, Erik; CERN. Geneva
1989-01-01
On the occasion of the 65th birthday of Georges Charpak and of his retirement, the Director-General and the EP Division invite you to a symposium in his h. Chairman : P. Lehmann. - J. Saudinos : Quelques applications des détecteurs gazeux à la médecine et à la biologie. - E. Uggerhøj : New steps in the channeling of relativistic particles. - R. Garwin : Remarks from the non-physical world. - G. Charpak : Final speech.
DiGeorge Syndrome: a not so rare disease
Fomin,Angela BF; Pastorino,Antonio Carlos; Kim,Chong Ae; Pereira,CA; Carneiro-Sampaio,Magda; Abe-Jacob,Cristina Miuki
2010-01-01
INTRODUCTION: The DiGeorge Syndrome was first described in 1968 as a primary immunodeficiency resulting from the abnormal development of the third and fourth pharyngeal pouches during embryonic life. It is characterized by hypocalcemia due to hypoparathyroidism, heart defects, and thymic hypoplasia or aplasia. Its incidence is 1:3000 live births and, despite its high frequency, little is known about its natural history and progression. ?This is probably due to diagnostic difficulties and the ...
Sampaio, Dayanna Souza; Almeida, Juliana Rodrigues Barboza; de Jesus, Hugo E; Rosado, Alexandre S; Seldin, Lucy; Jurelevicius, Diogo
2017-11-01
Anaerobic diesel fuel Arctic (DFA) degradation has already been demonstrated in Antarctic soils. However, studies comparing the distribution of anaerobic bacterial groups and of anaerobic hydrocarbon-degrading bacteria in Antarctic soils containing different concentrations of DFA are scarce. In this study, functional genes were used to study the diversity and distribution of anaerobic hydrocarbon-degrading bacteria (bamA, assA, and bssA) and of sulfate-reducing bacteria (SRB-apsR) in highly, intermediate, and non-DFA-contaminated soils collected during the summers of 2009, 2010, and 2011 from King George Island, Antarctica. Signatures of bamA genes were detected in all soils analyzed, whereas bssA and assA were found in only 4 of 10 soils. The concentration of DFA was the main factor influencing the distribution of bamA-containing bacteria and of SRB in the analyzed soils, as shown by PCR-DGGE results. bamA sequences related to genes previously described in Desulfuromonas, Lautropia, Magnetospirillum, Sulfuritalea, Rhodovolum, Rhodomicrobium, Azoarcus, Geobacter, Ramlibacter, and Gemmatimonas genera were dominant in King George Island soils. Although DFA modulated the distribution of bamA-hosting bacteria, DFA concentration was not related to bamA abundance in the soils studied here. This result suggests that King George Island soils show functional redundancy for aromatic hydrocarbon degradation. The results obtained in this study support the hypothesis that specialized anaerobic hydrocarbon-degrading bacteria have been selected by hydrocarbon concentrations present in King George Island soils.
George Herbert Mead's Contribution to the Philosophy of American Education.
Renger, Paul, III
1980-01-01
George Herbert Mead's general philsophy showed that he regarded the development of distinctively human behavior as essentially the result of an individual's meaningful participation in the social process of the community to which he belongs. Mead believed that education was a social process involving the meaningful interaction and communication…
22nd Spring Research Festival Showcases Fort Detrick Science | Poster
Rainy weather couldn’t dampen the spirits of visitors to the 2018 Spring Research Festival, which brought together scientists from the Frederick National Laboratory (FNL), NCI at Frederick, and the U.S. Army Medical Research and Materiel Command (USAMRMC) and showcased the important research that takes place every day at Fort Detrick.
Fort Valley studies: A natural laboratory for research and education
Brian W. Geils
2008-01-01
Drought, wildfire, extinction, and invasive species are considered serious threats to the health of our forests. Although these issues have global connections, we most readily see their consequences locally and attempt to respond with management based on science. For 100 years, the Fort Valley Experimental Forest (FVEF) has provided educational and experimental support...
President Arnold Rüütel andis president George W. H. Bushile üle Maarjamaa Risti / Kärt Ulman
Ulman, Kärt
2005-01-01
President Arnold Rüütel andis New Yorgis endisele USA presidendile Georg Bushile Eesti iseseisvuspüüdluste toetamise eest Maarjamaa Risti I klassi ordeni. Vt. samas lühiintervjuud president George W. H. Bushiga. Töövisiit New Yorki 13.-17.09.2005
How confident is Fort McKay that industry can reclaim oil sand development
Energy Technology Data Exchange (ETDEWEB)
Fitzpatrick, C. [Fort McKay First Nations, AB (Canada)
2004-02-05
This presentation described how traditional environmental knowledge (TEK) can provide valuable information for both the reclamation design and assessment of oil sand development in Fort McKay. Conservation is valued by the Fort McKay First Nations communities who claim that current reclamation methods are too slow, and that the land is not being brought back to its original use with the uniqueness of the boreal landscape. Elders have noted that each year the water level in the Athabasca River is lower. The blowing tailings and coke dust are causing trees to dye and driving animals away. There is concern that the animals that remain may not be safe to eat. The Fort McKay First Nation community has stated that it will view reclamation as a success only when it functions with proof over many generations. The major concerns include: salt in the water draining from reclaimed areas; salt in the soils of reclaimed area; muskeg cannot be recreated; and, the issue of whether cranberry, blueberry and streambank forest areas can be recreated, along with traditional medicinal plants. Other concerns include the loss of rivers such as the Beaver Creek and Tar River, and that the water in reclaimed areas may not be suitable for animals to live in or to drink. tabs., figs.
How confident is Fort McKay that industry can reclaim oil sand development
International Nuclear Information System (INIS)
Fitzpatrick, C.
2004-01-01
This presentation described how traditional environmental knowledge (TEK) can provide valuable information for both the reclamation design and assessment of oil sand development in Fort McKay. Conservation is valued by the Fort McKay First Nations communities who claim that current reclamation methods are too slow, and that the land is not being brought back to its original use with the uniqueness of the boreal landscape. Elders have noted that each year the water level in the Athabasca River is lower. The blowing tailings and coke dust are causing trees to dye and driving animals away. There is concern that the animals that remain may not be safe to eat. The Fort McKay First Nation community has stated that it will view reclamation as a success only when it functions with proof over many generations. The major concerns include: salt in the water draining from reclaimed areas; salt in the soils of reclaimed area; muskeg cannot be recreated; and, the issue of whether cranberry, blueberry and streambank forest areas can be recreated, along with traditional medicinal plants. Other concerns include the loss of rivers such as the Beaver Creek and Tar River, and that the water in reclaimed areas may not be suitable for animals to live in or to drink. tabs., figs
The Fort McMurray Demonstration Project in Social Marketing: theory, design, and evaluation.
Guidotti, T L; Ford, L; Wheeler, M
2000-02-01
The Fort McMurray Demonstration Project in Social Marketing is a multifaceted program that applies the techniques of social marketing to health and safety. This paper describes the origins of the project and the principles on which it was based. VENUE: Fort McMurray, in the province of Alberta, Canada, was selected because the community had several community initiatives already underway and the project had the opportunity to demonstrate "value added." The project is distinguished from others by a model that attempts to achieve mutually reinforcing effects from social marketing in the community as a whole and from workplace safety promotion in particular. Specific interventions sponsored by the project include a media campaign on cable television, public activities in local schools, a community safety audit, and media appearance by a mascot that provides visual identity to the project, a dinosaur named "Safetysaurus." The project integrated its activities with other community initiatives. The evaluation component emphasizes outcome measures. A final evaluation based on injury rates and attitudinal surveys is underway. Baseline data from the first round of surveys have been compiled and published. In 1995, Fort McMurray became the first city in North America to be given membership in the World Health Organization's Safe Community Network.
Water quality and hydrology in the Fort Belvoir area, Virginia, 1954-55
Durfor, Charles N.
1961-01-01
This report summarizes the results of an investigation of water quality and hydrology in the Fort Belvoir, Va., area for the period August 1954 to September 1955. It summarizes and evaluates information about the water resources of this area that are pertinent to the choice of location and operation of an Army nuclear power reactor. The quantity, quality, nature, and use of the local water that might be affected by the location and operation of a reactor in the area were subjects of investigation. Variations in the quality of the water caused by variation in streamflow, tidal effects, and pollution were important facets of the investigation. During extended periods of low streamflow in the Potomac River (usually in the late summer months), salty water moves upstream from Chesapeake Bay and increases the dissolved solids content of the surface waters adjacent to Fort Belvoir. When the streamflow is low the concentration of dissolved solids in the water near the river bottom exceeds that near the surface. The waters in Gunston Cove usually contain more dissolved oxygen than those in the Potomac River. During the summer, the content of dissolved oxygen in the cove waters frequently exceeds 100 percent of saturation. Surface floats that were released on a flood tide in Gunston Cove moved toward the inner portion of the cove in the same direction as the wind and the tide. The maximum average velocity of these floats was 0.65 feet per second. On an ebb tide, many surface floats that were released in Gunston Cove moved toward the inner portion of the cove in the direction of the wind, in opposition to the direction of the tidal movement. Floats released near the mouth of the cove on the same tide, moved with the tide out of the cove through a narrow pass at the end of a submerged sandbar extending from the Fort Belvoir shoreline. The maximum average velocity of the floats in the pass on this ebb tide was 0.85 feet per second. Measurements of subsurface flow direction
A shell-derived time history of bomb 14C on Georges Bank and its Labrador Sea implications
International Nuclear Information System (INIS)
Weidman, C.R.; Jones, G.A.
1993-01-01
Bomb-produced radiocarbon has been used in the past as an important tracer of ocean circulation and as a valuable tool for calculating CO 2 air-sea exchange. However, previous studies of the ocean's time-varying bomb 14 C record have been confined exclusively to analyzing banded corals, and thus their application has been limited to the lower latitudes. The first time history of bomb 14 C from the high-latitude North Atlantic Ocean is obtained from a 54-year-old mollusc specimen, (Bivalvia) Arctica islandica, which was collected live from Georges Bank (41 degrees N) in 1990. The annual growth bands of its shell were analyzed for Δ 14 C using accelerator mass spectrometry, producing a Δ 14 C time history from 1939 to 1990. The depleted condition of the Georges Bank bomb 14 C signal relative to two coral-derived North Atlantic Δ 14 C time histories suggests a significant deepwater source for the waters on Georges Bank. Supported by previous work linking the origin of waters on Georges Bank to the Labrador Sea, the Δ 14 C budget on Georges Bank is modeled as Labrador Sea water, which largely becomes confined to the shelf and partially equilibrates with the atmosphere during a 1-year transit time from the Labrador Sea to Georges Bank. This model is also used to estimate a time history of bomb 14 C for the Labrador Sea. Prebomb Δ 14 C values calculated for the surface Labrador Sea suggest that a greater inventory of bomb 14 C has accumulated here than has previously been reported. Deduced variations in the ventilation and/or 14 CO 2 uptake rates in the Labrador Sea correspond with observed changes in surface salinity of the Labrador Sea, suggesting a reduction in deepwater formation during the late 1960s and 1970s. 59 refs., 11 figs., 2 tabs
2009 Federal Emergency Management Agency (FEMA) Topographic LiDAR: Fort Kent, Maine
National Oceanic and Atmospheric Administration, Department of Commerce — Camp Dresser McKee Inc. contracted with Sanborn Map Company to provide LiDAR mapping services for Fort Kent, Maine. Utilizing multi-return systems, Light Detection...
Bastion on the Border: Fort Bliss, 1854-1943
1993-01-01
Journals , Record Group (RG) 165, Records of the War Department General and Special Staffs, National Archives, Washington, D.C. "’Richard Estrada, Border...it was the Fort Bliss garrison and the other troops deployed by Steever in the El Paso Patrol District that would have to provide the figurative glue ...little military value. For example, on March 30 three carloads of oats, flour , corn, and hay were dispatched; on April 7 fourteen carloads of hay, gasoline
76 FR 77684 - Establishment of the Fort Ross-Seaview Viticultural Area
2011-12-14
...; Treasury decision. SUMMARY: This Treasury decision establishes the 27,500-acre ``Fort Ross-Seaview... may purchase. DATES: Effective Date: January 13, 2012. FOR FURTHER INFORMATION CONTACT: Elisabeth C... may purchase. Establishment of a viticultural area is neither an approval nor an endorsement by TTB of...
Directory of Open Access Journals (Sweden)
Furkan Erol Karabekmez
2015-01-01
Full Text Available The objectives of this study are to assess the velopharyngeal dimensions using cephalometric variables of the nasopharynx and oropharynx as well as to compare the Le Fort I osteotomy technique to Zisser’s anterior maxillary osteotomy technique based on patients’ outcomes within early and late postoperative follow-ups. 15 patients with severe maxillary deficiency treated with Le Fort I osteotomy and maxillary segmental osteotomy were assessed. Preoperative, early postoperative, and late postoperative follow-up lateral cephalograms, patient histories, and operative reports are reviewed with a focus on defined cephalometric landmarks for assessing velopharyngeal space dimension and maxillary movement (measured for three different tracing points. A significant change was found between preoperative and postoperative lateral cephalometric measurements regarding the distance between the posterior nasal spine and the posterior pharyngeal wall in Le Fort I osteotomy cases. However, no significant difference was found between preoperative and postoperative measurements in maxillary segmental osteotomy cases regarding the same measurements. The velopharyngeal area calculated for the Le Fort I osteotomy group showed a significant difference between the preoperative and postoperative measurements. Le Fort I osteotomy for advancement of upper jaw increases velopharyngeal space. On the other hand, Zisser’s anterior maxillary segmental osteotomy does not alter the dimension of the velopharyngeal space significantly.
Adeno-Associated Virus Gene Therapy in a Sheep Model of Tay-Sachs Disease.
Gray-Edwards, Heather L; Randle, Ashley N; Maitland, Stacy A; Benatti, Hector R; Hubbard, Spencer M; Canning, Peter F; Vogel, Matthew B; Brunson, Brandon L; Hwang, Misako; Ellis, Lauren E; Bradbury, Allison M; Gentry, Atoska S; Taylor, Amanda R; Wooldridge, Anne A; Wilhite, Dewey R; Winter, Randolph L; Whitlock, Brian K; Johnson, Jacob A; Holland, Merilee; Salibi, Nouha; Beyers, Ronald J; Sartin, James L; Denney, Thomas S; Cox, Nancy R; Sena-Esteves, Miguel; Martin, Douglas R
2018-03-01
Tay-Sachs disease (TSD) is a fatal neurodegenerative disorder caused by a deficiency of the enzyme hexosaminidase A (HexA). TSD also occurs in sheep, the only experimental model of TSD that has clinical signs of disease. The natural history of sheep TSD was characterized using serial neurological evaluations, 7 Tesla magnetic resonance imaging, echocardiograms, electrodiagnostics, and cerebrospinal fluid biomarkers. Intracranial gene therapy was also tested using AAVrh8 monocistronic vectors encoding the α-subunit of Hex (TSD α) or a mixture of two vectors encoding both the α and β subunits separately (TSD α + β) injected at high (1.3 × 10 13 vector genomes) or low (4.2 × 10 12 vector genomes) dose. Delay of symptom onset and/or reduction of acquired symptoms were noted in all adeno-associated virus-treated sheep. Postmortem evaluation showed superior HexA and vector genome distribution in the brain of TSD α + β sheep compared to TSD α sheep, but spinal cord distribution was low in all groups. Isozyme analysis showed superior HexA formation after treatment with both vectors (TSD α + β), and ganglioside clearance was most widespread in the TSD α + β high-dose sheep. Microglial activation and proliferation in TSD sheep-most prominent in the cerebrum-were attenuated after gene therapy. This report demonstrates therapeutic efficacy for TSD in the sheep brain, which is on the same order of magnitude as a child's brain.
Opening remarks for the Fort Valley Centennial Celebration (P-53)
G. Sam Foster
2008-01-01
The Rocky Mountain Research Station recognizes and values the contributions of our scientists and collaborators for their work over the past century at Fort Valley Experimental Forest. With the help of our partners and collaborators, Rocky Mountain Research Station is working to improve coordination across its research Program Areas and Experimental Forests and Ranges...
Mehta, Nikita; Lazarin, Gabriel A; Spiegel, Erica; Berentsen, Kathleen; Brennan, Kelly; Giordano, Jessica; Haque, Imran S; Wapner, Ronald
2016-09-01
Carrier screening for Tay-Sachs disease is performed by sequence analysis of the HEXA gene and/or hexosaminidase A enzymatic activity testing. Enzymatic analysis (EA) has been suggested as the optimal carrier screening method, especially in non-Ashkenazi Jewish (non-AJ) individuals, but its utilization and efficacy have not been fully evaluated in the general population. This study assesses the reliability of EA in comparison with HEXA sequence analysis in non-AJ populations. Five hundred eight Hispanic and African American patients (516 samples) had EA of their leukocytes performed and 12 of these patients who tested positive by EA ("carriers") had subsequent HEXA gene sequencing performed. Of the 508 patients, 25 (4.9%) were EA positive and 40 (7.9%) were inconclusive. Of the 12 patients who were sequenced, 11 did not carry a pathogenic variant and one carried a likely deleterious mutation (NM_000520.4(HEXA):c.1510C>T). High inconclusive rates and poor correlation between positive/inconclusive enzyme results and identification of pathogenic mutations suggest that ethnic-specific recalibration of reference ranges for EA may be necessary. Alternatively, HEXA gene sequencing could be performed.
1992-09-01
APO NY 09052 CDR US ARMY NATICK RD&E CTR DOD PROJ MGR, MOBILE ELECTRIC POWER ATTN: SATNC-US US ARMY TROOP SUPPORT COMMAND NATICK MA 01760-5020 ATUN ...US ARMY QUARTERMASTER SCHOOL ATUN : LOEA-PL (MR LeVAN) I ATTN: ATSM-CDM 1 NEW CUMBERLAND PA 17070 ATSM-PWD I FORT LEE VA 23801 PETROLEUM FIELD OFFICE...ARTILLERY CENTER US ARMY INFANTRY SCHOOL & FORT BLISS ATTN: ATSH-CD-MIS-M I ATUN : ATZC-ISL-PP 3 ATSH-CD-TSM-T 1 ATZC-ISL-MM 3 FORT BENNING GA 31905-5400
International Nuclear Information System (INIS)
Ball, S.J.; Cleveland, J.C.; Harrington, R.M.
1985-01-01
The ORNL safety analysis program for the HTGR was established in 1974 to provide technical assistance to the USNRC on licensing questions for both Fort St. Vrain and advanced plant concepts. The emphasis has been on development of major component and system dynamic simulation codes, and use of these codes to analyze specific licensing-related scenarios. The program has also emphasized code verification, using Fort St. Vrain data where applicable, and comparing results with industry-generated codes. By the use of model and parameter adjustment routines, safety-significant uncertainties have been identified. A major part of the analysis work has been done for the Fort St. Vrain HTGR, and has included analyses of FSAR accident scenario re-evaluations, the core block oscillation problem, core support thermal stress questions, technical specification upgrade review, and TMI action plan applicability studies. The large, 2240-MW(t) cogeneration lead plant design was analyzed in a multi-laboratory cooperative effort to estimate fission product source terms from postulated severe accidents
Magnification-temperature correlation: The dark side of integrated Sachs-Wolfe measurements
International Nuclear Information System (INIS)
LoVerde, Marilena; Hui, Lam; Gaztanaga, Enrique
2007-01-01
Integrated Sachs-Wolfe (ISW) measurements, which involve cross-correlating the microwave background anisotropies with the foreground large-scale structure (e.g. traced by galaxies/quasars), have proven to be an interesting probe of dark energy. We show that magnification bias, which is the inevitable modulation of the foreground number counts by gravitational lensing, alters both the scale dependence and amplitude of the observed ISW signal. This is true especially at high redshifts because (1) the intrinsic galaxy-temperature signal diminishes greatly back in the matter-dominated era, (2) the lensing efficiency increases with redshift and (3) the number count slope generally steepens with redshift in a magnitude limited sample. At z > or approx. 2, the magnification-temperature correlation dominates over the intrinsic galaxy-temperature correlation and causes the observed ISW signal to increase with redshift, despite dark energy subdominance--a result of the fact that magnification probes structures all the way from the observer to the sources. Ignoring magnification bias therefore can lead to (significantly) erroneous conclusions about dark energy. While the lensing modulation opens up an interesting high z window for ISW measurements, high redshift measurements are not expected to add much new information to low redshift ones if dark energy is indeed the cosmological constant. This is because lensing introduces significant covariance across redshifts. The most compelling reasons for pursuing high redshift ISW measurements are to look for potential surprises such as early dark energy domination or signatures of modified gravity. We conclude with a discussion of existing measurements, the highest redshift of which is at the margin of being sensitive to the magnification effect. We also develop a formalism which might be of more general interest: to predict biases in estimating parameters when certain physical effects are ignored in interpreting observations
Operational experience at Fort St. Vrain
International Nuclear Information System (INIS)
Bramblett, G.C.; Fisher, C.R.; Swart, F.E.
1981-01-01
The Fort St. Vrain (FSV) station, a 330-MW(e) single reheat steam cycle powered by a high-temperature gas-cooled reactor (HTGR), is the first HTGR to enter commercial operation. Designed and built by General Atomic Company (GA), the plant is owned and operated by Public Service Company of Colorado (PSC). Many unique design features have been incorporated into this reactor system, including high-pressure helium as the primary system coolant, a graphite-moderated prismatic block core design, fission-product-containing carbide coatings on both fissile and fertile fuel particles, steam-driven helium circulators turning on water bearings, and once-through steam generators. All of these systems are contained in a prestressed concrete reactor vessel (PCRV). Extensive testing has been conducted during the rise to power following first criticality early in 1974 to verify system design performance. During this period, the plant has operated at power levels up to 70% and produced over one billion kilowatt hours of electricity. In 1979, the first refueling was conducted in conjunction with an extensive in-core inspection, the addition of in-core instrumentation, and a planned removal of a circulator for inspection. Later in the year, a scheduled shutdown was undertaken for surveillance tests, insertion of core region constraint devices (RCDs), and other maintenance. Fort St. Vrain has encountered problems of the type that would be expected in a first-of-a-kind system. The plant is currently restricted to 70% of design power by the Nuclear Regulatory Commission (NRC) pending resolution of the core region gas outlet temperature fluctuation problem. Even so, the basic performance of the HTGR concept and all of the unique design features have been successfully demonstrated. The system has been characterized by low personnel radiation exposures, operational flexibility, and long time afforded for status evaluation and response. (author)
Automated Environmental Data Collection at Fort Benning, Georgia, from May 1999 to July 2001
National Research Council Canada - National Science Library
Hahn, Charles
2002-01-01
The Department of Defense, Strategic Environmental Research and Development Program, Ecosystem Management Project, Ecosystem Characterization and Monitoring initiative Program at Fort Benning, Georgia...
1992-04-01
the officers’ quarters, a hospital, and an inspector’s quarters (Greene 1982:128-129). The fort itself was a regular pentagon with bastions at each...Outside of the moat another brick wall was constructed, facing a second ditch. A bridge over the second ditch led southward to a water battery whose...Archaeological Swrveys and Evaluations at Fort Jackson du Pratz, Le Page 1975 The History of Louisiana. Louisiana American Revolution Bicentennial Commission
Drivers Dexterity: George Osodi's Oeuvre on Safety on the Nigerian ...
African Journals Online (AJOL)
This paper attempted a reading of the Nigerian condition using the censure of images culled from an exhibition by the Nigerian photographer George Osodi. Drawing attention to the shapes of the images and imageries that constitute the profile of the condition of a major infrastructure, the road and transportation, I have ...
DIGITAL PRESERVATION OF THE QUON SANG LUNG LAUNDRY BUILDING, FORT MACLEOD, ALBERTA
Directory of Open Access Journals (Sweden)
P. Dawson
2017-08-01
Full Text Available This paper describes the results of an emergency recording and archiving of a historic structure in Southern Alberta and explores the lessons learned. Digital recording of the Quon Sang Lung Laundry building in Fort Macleod, Alberta, was a joint initiative between Alberta Culture and Tourism and the University of Calgary. The Quon Sang Lung Laundry was a boomtown-style wood structure situated in the Fort Macleod Provincial Historic Area, Alberta. Built in the mid-1800s, the structure was one of the four buildings comprising Fort Macleod’s Chinatown. Its association with Chinese immigration, settlement, and emergence of Chinese-owned businesses in early twentieth-century Alberta, made the Quon Sang Lung Laundry a unique and very significant historic resource. In recent years, a condition assessment of the structure indicated that the building was not safe and that the extent of the instability could lead to a sudden collapse. In response, Alberta Culture and Tourism engaged the Departments of Anthropology and Archaeology and Geomatics Engineering from the University of Calgary, to digitally preserve the laundry building. A complete survey including the laser scanning of all the remaining elements of the original structure, was undertaken. Through digital modeling, the work guarantees that a three-dimensional representation of the building is available for future use. This includes accurate 3D renders of the exterior and interior spaces and a collection of architectural drawings comprising floor plans, sections, and elevations.
Le Fort III Distraction With Internal vs External Distractors: A Cephalometric Analysis.
Robertson, Kevin J; Mendez, Bernardino M; Bruce, William J; McDonnell, Brendan D; Chiodo, Michael V; Patel, Parit A
2018-05-01
This study compares the change in midface position following Le Fort III advancement using either rigid external distraction (group 1) or internal distraction (group 2). We hypothesized that, with reference to right-facing cephalometry, internal distraction would result in increased clockwise rotation and inferior displacement of the midface. Le Fort III osteotomies and standardized distraction protocols were performed on 10 cadaveric specimens per group. Right-facing lateral cephalograms were traced and compared across time points to determine change in position at points orbitale, anterior nasal spine (ANS), A-point, and angle ANB. Institutional. Twenty cadaveric head specimens. Standard subcranial Le Fort III osteotomies were performed from a coronal approach and adequately mobilized. The specified distraction mechanism was applied and advanced by 15 mm. Changes of position were calculated at various skeletal landmarks: orbitale, ANS, A-point, and ANB. Group 1 demonstrated relatively uniform x-axis advancement with minimal inferior repositioning at the A-point, ANS, and orbitale. Group 2 demonstrated marked variation in x-axis advancement among the 3 points, along with a significant inferior repositioning and clockwise rotation of the midface ( P External distraction resulted in more uniform advancement of the midface, whereas internal distraction resulted in greater clockwise rotation and inferior displacement. External distraction appears to provide increased vector control of the midface, which is important in creating a customized distraction plan based on the patient's individual occlusal and skeletal needs.
Digital Preservation of the Quon Sang Lung Laundry Building, Fort Macleod, Alberta
Dawson, P.; Baradaran, F.; Jahraus, A.; Rubalcava, E.; Farrokhi, A.; Robinson, C.
2017-08-01
This paper describes the results of an emergency recording and archiving of a historic structure in Southern Alberta and explores the lessons learned. Digital recording of the Quon Sang Lung Laundry building in Fort Macleod, Alberta, was a joint initiative between Alberta Culture and Tourism and the University of Calgary. The Quon Sang Lung Laundry was a boomtown-style wood structure situated in the Fort Macleod Provincial Historic Area, Alberta. Built in the mid-1800s, the structure was one of the four buildings comprising Fort Macleod's Chinatown. Its association with Chinese immigration, settlement, and emergence of Chinese-owned businesses in early twentieth-century Alberta, made the Quon Sang Lung Laundry a unique and very significant historic resource. In recent years, a condition assessment of the structure indicated that the building was not safe and that the extent of the instability could lead to a sudden collapse. In response, Alberta Culture and Tourism engaged the Departments of Anthropology and Archaeology and Geomatics Engineering from the University of Calgary, to digitally preserve the laundry building. A complete survey including the laser scanning of all the remaining elements of the original structure, was undertaken. Through digital modeling, the work guarantees that a three-dimensional representation of the building is available for future use. This includes accurate 3D renders of the exterior and interior spaces and a collection of architectural drawings comprising floor plans, sections, and elevations.
Safety and licensing analyses for the Fort St. Vrain HTGR
International Nuclear Information System (INIS)
Ball, S.J.; Conklin, J.C.; Harrington, R.M.; Cleveland, J.C.; Clapp, N.E. Jr.
1982-01-01
The Oak Ridge National Laboratory (ORNL) safety analysis program for the HTGR includes development and verification of system response simulation codes, and applications of these codes to specific Fort St. Vrain reactor licensing problems. Licensing studies addressed the oscillation problems and the concerns about large thermal stresses in the core support blocks during a postulated accident
Early thinning experiments established by the Fort Valley Experimental Forest
Benjamin P. De Blois; Alex. J. Finkral; Andrew J. Sanchez Meador; Margaret M. Moore
2008-01-01
Between 1925 and 1936, the Fort Valley Experimental Forest (FVEF) scientists initiated a study to examine a series of forest thinning experiments in second growth ponderosa pine stands in Arizona and New Mexico. These early thinning plots furnished much of the early background for the development of methods used in forest management in the Southwest. The plots ranged...
Directory of Open Access Journals (Sweden)
Yoke Mui LIM
2014-12-01
Full Text Available Being inscribed as a UNESCO World Heritage City since 2008, this scenario calls into question the voices, the participation and the aspirations of George Town residents themselves in the process of planning and conserving their city. As an extension of a similar project undertaken in 2006, prior to the UNESCO listing, the present study sought to explore and understand the residents’ perceptions and preferences of George Town as a Heritage City after the UNESCO listing. Using the same set of samples (i.e. 400 inner city residents, the findings from this study revealed the change of residents’ preference as well as their appreciation towards the value of heritage and its economic potential. More respondents are supportive on the protection of heritage buildings and maintaining a heritage city. The older generations are the advocates of the heritage houses and they are more willing to pay higher prices to own a heritage house in the city. heritage awareness, urban conservation, resident perspectives, George Town.
Ambach, Georg, 1952-2006
2004-01-01
Karl Saarmannist ja tema teesidest seoses karistusseadustikuga ja tegevusest kriminaalreformi läbiviimisel. Karistusseadustiku eelnõu väljatöötamisest. Mag. iur. Georg Ambach on professor Karl Saarmanni Seltsi juhatuse esimees
2013-05-31
... to Release Airport Property at the Fort Worth Spinks Airport, Fort Worth, Texas AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of request to release airport property. SUMMARY: The FAA... the provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st...
Feasibility Study for an Off-Post, Primary Care Clinic at Fort Campbell, Kentucky
National Research Council Canada - National Science Library
Kvalevog, Kristen J
2005-01-01
.... Over 90,679 beneficiaries currently live in -the-Fort Campbell-catchment area and receive primary care at Blanchfield Army Community Hospital through the Red, White, Blue, Gold, and Young Eagle Clinics...
Interactions between surface waters in King George Island, Antarctica - a stable isotope perspective
Perşoiu, Aurel; Bădăluşă, Carmen
2017-04-01
In this paper we present a first study of the isotopic composition of surface waters in the southern peninsulas (Barton, Fildes, Weaver and Potter) of King George Island, Antarctica. We have collected > 200 samples of snow and snowmelt, water (lake, river and spring), ice (glacier ice and permafrost) from the four peninsulas in February 2016 and analyzed them for their oxygen and hydrogen stable isotopic composition. Samples from lake water (50+) indicate a clear west-east depletion trend, suggesting a rain-out process as air masses are moving westward (and are progressively depleted in heavy isotopes) from their origin in the Drake Passage. In both Fildes and Barton Peninsulas, permafrost samples have the heaviest isotopic composition, most probably due to preferential incorporation of heavy isotopes in the ice during freezing (and no fractionation during melting). As permafrost melts, the resulting water mixes with isotopically lighter infiltrated snowmelt, and thus the groundwater has a lower isotopic composition. Further, lake and river (the later fed by lakes) water has the lightest isotopic composition, being derived mostly from the melting of light snow and glacier ice. It seems feasible to separate isotopically water in lakes/rivers (largely fed by melting multi-year glaciers and snow) and water from melting of snow/ground ice This preliminary study suggests that it is possible to separate various water sources in the southern peninsulas of King George Island, and this separation could be used to study permafrost degradation, as well as feeding and migration patterns in the bird fauna, with implications for protection purposes. Acknowledgments. The National Institute of Research and Development for Biological Sciences (Bucharest, Romania) and the Korean polar institute financially supported fieldwork in King George Island. We thank the personal at King Sejong (South Korea), Belingshaussen (Russia) and Carlini (Argentina) stations in King George Island for
Craik, Fergus
2017-10-01
Presents an obituary for George Mandler, who died in London on May 6, 2016 at the age of 91. Mandler was one of the pioneers of the cognitive revolution in psychology. He was instrumental in moving the study of human learning from notions based largely on associations to a view of memory as an organized, nested hierarchical structure. Mandler was also a major proponent of the dual-process theory of recognition memory, in which general feelings of familiarity are distinguished from the context-rich experience of recollection. He brought the study of emotion into prominence, suggesting how emotion and cognition are related. Finally, he repatriated the concept of consciousness from its intellectual exile under behaviorism, stating boldly in 1975 that the construct was respectable, useful, and probably necessary. Mandler edited the Psychological Review from 1970 to 1976, chaired the Governing Board of the Psychonomic Society, and was president of APA Divisions 1 (General Psychology) and 3 (Experimental Psychology and Cognitive Science). (PsycINFO Database Record (c) 2017 APA, all rights reserved).
2010-01-01
All of CERN was deeply saddened to learn the news that our friend and colleague, Georges Charpak, passed away on 29 September 2010. There are few people who can honestly be said to have changed the world, but Charpak was one of them. Born in Dabrovika, Poland on 8 March 1924, Charpak fled the Nazi regime under a false identity and moved to France where he joined the resistance. Arrested and deported to Dachau, he returned to France after the war and took French nationality in 1946. A student of Frédéric Joliot-Curie at the Collège de France, he joined CERN in 1959, just five years after the Organization’s foundation, and he certainly left his mark. From the start, Charpak applied himself to the development of new particle detector techniques. His outstanding and pioneering efforts revolutionised particle physics, taking the field into the electronic age. It is fair to say that without the developments pioneered by him, particularly the invention of t...
78 FR 3479 - Notice of Public Meeting of Fort Scott Council
2013-01-16
... submitted on cards that will be provided at the meeting, via mail to Laurie Fox, Presidio Trust, 103... stated prominently at the beginning of the comments. The Trust will make available for public inspection... PRESIDIO TRUST Notice of Public Meeting of Fort Scott Council AGENCY: The Presidio Trust. ACTION...
Plea Bargaining: A Recreation of George Orwell's Animal Farm in ...
African Journals Online (AJOL)
Animal Farm is an allegorical novel by George Orwell in which he depicted social injustice precipitated by the insincerity of leadership and the betrayal of the people by their leaders which has made the novel relevant as the experience depicted therein “seamlessly steps into the realities of everyday life” (Achebe 2012) in ...
The George Wallace Shooting: News Diffusion and the Sleeper Effect.
Steinfatt, Thomas M.; And Others
Previous studies conclude that the assassination attempt on George C. Wallace was a news event of high, but not maximum, importance, implying that the majority of respondents in any sample would report first learning of the attack via mass media sources. The authors interviewed 144 persons in Ann Arbor, Michigan, regarding their awareness of the…
Vehicles to Belief: Aristotle's Enthymeme and George Campbell's Vivacity Compared.
Roob, Andy
The central concepts from two rhetorical systems (the enthymeme in Aristotle's rhetoric and vivacity in George Campbell's) may be understood as the connection between speech act and ascension to belief. A review of the literature indicates a gap in the scholarly works seeking to compare and contrast the periods developed by D. Ehninger's systems…
Fort Hills Oil Sands Project No Net Loss Lake earthfill structure
Energy Technology Data Exchange (ETDEWEB)
Blakely, D.; Sawatsky, L. [Golder Associates Ltd., Calgary, AB (Canada); Wog, K.; Paz, S. [Alberta Environment, Edmonton, AB (Canada). Water Management Operations; Chernys, S. [Petro-Canada, Calgary, AB (Canada)
2007-07-01
The Fort Hills Oil Sands Project (FHOSP) is located north of Fort McMurray, Alberta. The Fort Hills Energy Corporation (FHEC) must compensate for fish habitat lost as a result of mine development that would disturb natural streams and lakes. FHEC planned to construct a fisheries compensation lake on the north end of its leased property, contained in part by an earthfill structure. Unlike most dam structures, the FHOSP No Net Loss Lake (NNLL) earthfill structure was planned solely for the creation of fisheries compensation habitat. Therefore, the NNLL earthfill structure must be designed with robust features that can handle any foreseeable environmental condition without failure, so that it may be accepted as a sustainable feature of the mine closure landscape. This paper discussed the design features of the NNLL earthfill structure. The paper presented information on the background of the project including regulatory criteria for the fisheries compensation habitat; fisheries compensation habitat location; and design criteria for the NNLL. The features of the NNLL earthfill structure were also discussed. In addition, the paper outlined the dam safety classification for earthfill structure and anticipated system performance. The proposed monitoring program and permanent closure plans were also discussed. It was concluded that the earthfill structure was designed with several features that would allow it to become a part of the closure landscape. These included a high width to height ratio, significant erosion protection, and an aggressive reclamation plan. These features will provide a sound basis for FHEC to apply for a reclamation certificate at the end of mine life. 3 refs., 3 tabs., 8 figs.
Fort Hood Building and Landscape Inventory with WWII and Cold War Context
2007-03-01
barracks, 1970s (NARA)........................................................... 112 Figure 37. Palmer Movie Theater (NARA...revised 1953) showing layout of Hood Village and trailer park (Fort Hood...arms ammunition storage building #92012 (ERDC-CERL, 2004). ......... 260 Figure 163: Radio reception building #92063 (ERDC-CERL, 2004
Fort St. Vrain decommissioning project
International Nuclear Information System (INIS)
Fisher, M.
1998-01-01
Public Service Company of Colorado (PSCo), owner of the Fort St. Vrain nuclear generating station, achieved its final decommissioning goal on August 5, 1997 when the Nuclear Regulatory Commission terminated the Part 50 reactor license. PSCo pioneered and completed the world's first successful decommissioning of a commercial nuclear power plant after many years of operation. In August 1989, PSCo decided to permanently shutdown the reactor and proceed with its decommissioning. The decision to proceed with early dismantlement as the appropriate decommissioning method proved wise for all stake holders - present and future - by mitigating potential environmental impacts and reducing financial risks to company shareholders, customers, employees, neighboring communities and regulators. We believe that PSCo's decommissioning process set an exemplary standard for the world's nuclear industry and provided leadership, innovation, advancement and distinguished contributions to other decommissioning efforts throughout the world. (author)
National Research Council Canada - National Science Library
Lane, F
1996-01-01
.... Due to the impending closure of the Defense Accounting Office at Fort Belvoir and the anticipated consolidation to the Rome Operating Location, New York, we did not perform a review of the management...
Revised Geologic Map of the Fort Garland Quadrangle, Costilla County, Colorado
Wallace, Alan R.; Machette, Michael N.
2008-01-01
The map area includes Fort Garland, Colo., and the surrounding area, which is primarily rural. Fort Garland was established in 1858 to protect settlers in the San Luis Valley, then part of the Territory of New Mexico. East of the town are the Garland mesas (basalt-covered tablelands), which are uplifted as horsts with the Central Sangre de Cristo fault zone. The map also includes the northern part of the Culebra graben, a deep structural basin that extends from south of San Luis (as the Sanchez graben) to near Blanca, about 8 km west of Fort Garland. The oldest rocks exposed in the map area are early Proterozic basement rocks (granites in Ikes Creek block) that occupy an intermediate structural position between the strongly uplifted Blanca Peak block and the Culebra graben. The basement rocks are overlain by Oligocene volcanic and volcaniclastic rocks of unknown origin. The volcanic rocks were buried by a thick sequence of basin-fill deposits of the Santa Fe Group as the Rio Grande rift formed about 25 million years ago. The Servilleta Basalt, a regional series of 3.7?4.8 Ma old flood basalts, was deposited within sediment, and locally provides a basis for dividing the group into upper and lower parts. Landslide deposits and colluvium that rest on sediments of the Santa Fe Group cover the steep margins of the mesas. Exposures of the sediment beneath the basalt and within the low foothills east of the Central Sangre de Cristo fault zone are comprised of siltstones, sandstones, and minor fluvial conglomerates. Most of the low ground surrounding the mesas and in the graben is covered by surficial deposits of Quaternary age. The alluvial deposits are subdivided into three Pleistocene-age units and three Holocene-age units. The oldest Pleistocene gravel (unit Qao) is preserved as isolated remnants that cap high surfaces north and east of Fort Garland. The primary geologic hazards in the map area are from earthquakes, landslides, and localized flooding. The Central
George Berkeley’s criticism to John Locke’s representationalism
Directory of Open Access Journals (Sweden)
Alberto Oya
2018-03-01
Full Text Available In his Treatise concerning the Principles of Human Knowledge, George Berkeley offers some arguments in order to criticize the materialist position. My aim in this paper is to expound and analyze in detail these arguments. Given that Berkeley’s criticism to materialism is, at the end, a criticism to John Locke’s representationalism, I will begin this paper explaining which are the core ideas of Locke’s proposal.
Georges Perec and the avant-garde in the visual arts
DEFF Research Database (Denmark)
Ørum, Tania
2006-01-01
Den franske forfatter Georges Perec tilhører 1960ernes avantgarde, og hans værker deler træk med samtidens billedkunst. Perec deler tresseravantgardens interesse for massekultur, dens kritik af den traditionelle kunstnerrolle og dens ønske om at bevæge sig på tværs af grænserne mellem kunst og li...
Fort Carson Building 1860 Biomass Heating Analysis Report
Energy Technology Data Exchange (ETDEWEB)
Hunsberger, Randolph [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tomberlin, Gregg [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gaul, Chris [National Renewable Energy Lab. (NREL), Golden, CO (United States)
2015-09-01
As part of the Army Net-Zero Energy Installation program, the Fort Carson Army Base requested that NREL evaluate the feasibility of adding a biomass boiler to the district heating system served by Building 1860. We have also developed an Excel-spreadsheet-based decision support tool--specific to the historic loads served by Building 1860--with which users can perform what-if analysis on gas costs, biomass costs, and other parameters. For economic reasons, we do not recommend adding a biomass system at this time.
Basewide Energy Study, Fort Wainwright Alaska: Volume 1-Executive Summary
1982-04-01
more accurate condensate wiett?Ing. 2.2 ENERGY OSAGE ANALISIS 4 top~down anay2ts was mad" of FY’•0 ener;’ uxage’ t Fort wrtsvrigFnt. The spporiIonments...vice, at each receptacle cluster . It should be thermally sensitlve. rtdtcing through-put from 600 watts at -SOOT to0soer power at 100? outside air
Flood-inundation maps for the St. Marys River at Fort Wayne, Indiana
Menke, Chad D.; Kim, Moon H.; Fowler, Kathleen K.
2012-01-01
Digital flood-inundation maps for a 9-mile reach of the St. Marys River that extends from South Anthony Boulevard to Main Street at Fort Wayne, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the City of Fort Wayne. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site, depict estimates of the areal extent of flooding corresponding to selected water levels (stages) at the USGS streamgage 04182000 St. Marys River near Fort Wayne, Ind. Current conditions at the USGS streamgages in Indiana may be obtained from the National Water Information System: Web Interface. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system. The NWS forecasts flood hydrographs at many places that are often collocated at USGS streamgages. That forecasted peak-stage information, also available on the Internet, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, water-surface profiles were simulated for the stream reach by means of a hydraulic one-dimensional step-backwater model. The model was calibrated using the most current stage-discharge relation at the USGS streamgage 04182000 St. Marys River near Fort Wayne, Ind. The hydraulic model was then used to simulate 11 water-surface profiles for flood stages at 1-ft intervals referenced to the streamgage datum and ranging from bankfull to approximately the highest recorded water level at the streamgage. The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from Light Detection and Ranging (LiDAR) data) in order to delineate the area flooded at each water level. A flood inundation map was generated for each water-surface profile stage (11 maps in all) so that for any given flood stage users will be
Obstetric patients admitted to the intensive care unit of Dr George ...
African Journals Online (AJOL)
require ICU level of care. S Afr J Crit Care 2017;33(1):12-14. ... at Dr George Mukhari Academic Hospital (DGMAH), Ga-Rankuwa,. SA. DGMAH is a ... day. The median length of ICU stay was 24 hours (range 1 - 17 days). Eighty-seven percent ...
Insurgency and American Foreign Policy: the case of George McGovern
Haar, Roberta
2017-01-01
As a distinct foreign-policy group, neoconservatives emerged in a period of social unrest and political cynicism—a time when insurgent presidential candidates can have profound effects on the outlook and conduct of foreign policy. The George McGovern insurgency is an important historical event that
RECORDANDO LA ESTRATEGIA DE SEGURIDAD DE GEORGE W.BUSH EN LA ERA DE DONALD TRUMP
Directory of Open Access Journals (Sweden)
Nelson Llanos Sierra
2017-12-01
Full Text Available Este trabajo analiza la estrategia de seguridad del presidente George W. Bush y su posible vinculación con el comportamiento internacional de Donald Trump, ahondando en las similitudes de ambos casos, tanto en sus objetivos como contexto internacional. Sobre la base del accionar de Trump durante los primeros meses de su mandato, este trabajo sugiere que el actual mandatario estadounidense está desarrollando, y consolidará, una estrategia de seguridad sustentada en principios, valores y objetivos comparables a aquellos defendidos por George W. Bush a inicios del presente siglo.
Fort St. Vrain improvement program plan. Draft final report
International Nuclear Information System (INIS)
1980-03-01
The restraints are described which inhibit the Fort St. Vrain (FSV) Nuclear Power Station, a high temperature gas cooled reactor (HTGR) plant, from achieving full power operation with high availability. The actions necessary to overcome these restraints are outlined. The restraints originated from problems in both hardware related and institutional areas. The report summarizes what has been accomplished, what is currently being done, and what should be done to resolve the problems
Ramachandran, Rajoo; Babu, Sellappan Rajamanickam; Ilanchezhian, Subramanian; Radhakrishnan, Prabhu Radhan
2015-01-01
DiGeorge syndrome is a congenital genetic disorder that affects the endocrine system, mainly the thymus and parathyroid glands. The syndrome produces different symptoms, which vary in severity and character between patients. It manifests with craniofacial dysmorphism and defects in the heart, parathyroid, and thymus. Patients can present with a palatal deformity and nasal speech. This rare entity is caused mainly due to deletion of chromosome 22q11.2. Radiographic evaluation of DiGeorge syndrome is necessary to define aberrant anatomy, evaluate central nervous system, craniofacial abnormalities, musculoskeletal system, and cardiothoracic contents. It also helps in planning surgical procedures and surgical reconstructions. We report a case of DiGeorge syndrome in a 4-month-old neonate and discuss the clinical, imaging, and cytogenetic findings that helped in the diagnosis of this rare entity.
DEFF Research Database (Denmark)
Taudal Poulsen, René
2014-01-01
Book review of: Rose George: Deep Sea and Foreign Going: Inside Shipping, the Invisible Industry that Brings you 90% of Everything. London :Portobello Books, 2013. 320 pp. ISBN 9781846272639......Book review of: Rose George: Deep Sea and Foreign Going: Inside Shipping, the Invisible Industry that Brings you 90% of Everything. London :Portobello Books, 2013. 320 pp. ISBN 9781846272639...
George Martin Baer, DVM, MPH, 1936-2009. The father of oral rabies vaccination
Directory of Open Access Journals (Sweden)
Paul E. Grunenwald, DVM, MSc
2009-09-01
Full Text Available George Martin Baer, known for his development of the oral rabies vaccine instrumental in rabies control in Europe, died on 2 June 2009 at the age of 73 in Mexico City, Mexico. He was born on 12 January 1936 in London, England, to German immigrants who had fled Nazi Germany. His family emigrated to the United States in 1940 where he grew up in New Rochelle, New York.George had a love of animals, particularly horses, which may have influenced his career path. He earned an undergraduate degree in agricultural sciences in 1954 from Cornell University followed by a degree in veterinary medicine in 1959. He then went on to earn a master’s degree in public health in 1960 from the University of Michigan. During some time in Mexico, George met and fell in love with his wife, Maria Olga Lara. Thanks to James H. Steele, his long-time friend and mentor, he started his public health career with the Centers for Disease Control (CDC and was assigned to the New York State Health Department where he learned epidemiology and virology. He went on to work on bat rabies at the CDC’s Southwest Rabies Investigations Laboratory in New Mexico. From 1966 to 1969, he worked with the National Institute for Livestock Research (Instituto Nacional de Investigaciones Pecuarias: INIP in Mexico and helped develop the Plan Derriengue to control paralytic bovine rabies which became the early work in the development of Mexico’s rabies control programmes. He returned to Atlanta in 1969 to direct the CDC Rabies Laboratory. There, he led a team of researchers in developing an oral rabies vaccine for wildlife, earning him the title ‘The Father of Oral Rabies Vaccination’. His text, The Natural History of Rabies, first published in 1975 and again in 1991, continues to be a definitive international reference for rabies control.After his retirement, George returned to Mexico and continued his research and training, working to develop not only public health programmes, but new
Management of Groin Abcess with Flaminal Forte and KerraMax Care
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Maggie Pugh
2016-04-01
Full Text Available The patient’s dressing plan using Flaminal Forte and KerraMax Care successfully managed the complexities of his wound, absorbing exudate, reducing pain on dressing, malodour and wound bioburden. Moreover, the plan encouraged patient concordance, reduced nursing consultation time and subsequently altered treatment plans for our patients with abscesses
Environmental Impact Statement Addressing Campus Development at Fort George Meade, Maryland
2010-09-01
Dumetella carolinensis), mockingbird (Mimus polyglyottos), Carolina chickadee (Poecile carolinensis), Carolina wren (Thryothorus ludovicianus), house wren...regulations, the MBTA makes it unlawful to pursue, hunt, take, capture, or kill ; attempt to take, capture or kill ; possess, offer to sell, barter...foreign country, any bird, part, nest, or egg that was captured, killed , taken, shipped, transported, or carried contrary to the laws from where it was
Gynecologic Malignancies Post-LeFort Colpocleisis
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Rayan Elkattah
2014-01-01
Full Text Available Introduction. LeFort colpocleisis (LFC is a safe and effective obliterative surgical option for older women with advanced pelvic organ prolapse who no longer desire coital activity. A major disadvantage is the limited ability to evaluate for post-LFC gynecologic malignancies. Methods. We present the first case of endometrioid ovarian cancer diagnosed after LFC and review all reported gynecologic malignancies post-LFC in the English medical literature. Results. This is the second reported ovarian cancer post-LFC and the first of the endometrioid subtype. A total of nine other gynecologic malignancies post-LFC have been reported in the English medical literature. Conclusions. Gynecologic malignancies post-LFC are rare. We propose a simple 3-step strategy in evaluating post-LFC malignancies.
2006-06-01
PHOTOVOLTAIC ENERGY AND FORT BLISS CASE BACKGROUND A. PHOTOVOLTAIC ENERGY The use of photovoltaic power systems is nothing new in the Department...against the Outback MPPT charge controller . This test will be done over a one month timeframe. The Arizona Power ISG test plan is contained in...cost-benefit analysis of conventional power versus emerging photovoltaic energy for the Army’s Fort Bliss in El Paso, TX. The project will also analyze
Neurosensory changes of palatal mucousa following Le Fort I osteotomy
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Bijan Movahedian Attar
2009-09-01
Full Text Available
This is the Final Report for the FRATIS Dallas-Fort Worth DFW prototype system. The FRATIS prototype in : DFW consisted of the following components: optimization algorithm, terminal wait time, route specific : navigation/traffic/weather, and advanced...
76 FR 22338 - Proposed Fort Ross-Seaview Viticultural Area; Comment Period Reopening
2011-04-21
... May 9, 2005, from all interested persons. In response to a request from a local wine industry member... the Fort Ross-Seaview viticultural area. Two local wine industry members supported the petition without qualification; a third industry member supported the viticultural area's establishment while...
Archeological Testing Fort Hood: 1994-1995. Volume 2
1996-10-01
ASSOCI TES, INC. (662-22) Archeological Testing at Fort Hood. 1994-199.5 569 -48-1941.1080-134 1935 -058 Figure 7.17 Selected Perforator Types: Awl and...Department of Anthropology, University of Arkansas. Huskey, V. 1935 An Archeological Survey of the Nueces Canyon of Texas, Bulletin of the Texas... epr 064lL.Tan I lms expected 08-FH1 Yellow 4 expected expedctd cd .9 15.Q W n• I less M 0 ~ *~Tax~on Total Total Inmr 53 nac na Vertebra.es 1. FcAuifnm
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Rajoo Ramachandran
2015-01-01
Full Text Available DiGeorge syndrome is a congenital genetic disorder that affects the endocrine system, mainly the thymus and parathyroid glands. The syndrome produces different symptoms, which vary in severity and character between patients. It manifests with craniofacial dysmorphism and defects in the heart, parathyroid, and thymus. Patients can present with a palatal deformity and nasal speech. This rare entity is caused mainly due to deletion of chromosome 22q11.2. Radiographic evaluation of DiGeorge syndrome is necessary to define aberrant anatomy, evaluate central nervous system, craniofacial abnormalities, musculoskeletal system, and cardiothoracic contents. It also helps in planning surgical procedures and surgical reconstructions. We report a case of DiGeorge syndrome in a 4-month-old neonate and discuss the clinical, imaging, and cytogenetic findings that helped in the diagnosis of this rare entity.
Assessment of pterygomaxillary separation in Le Fort I Osteotomy in class III patients.
Ueki, Koichiro; Hashiba, Yukari; Marukawa, Kohei; Okabe, Katsuhiko; Alam, Shamiul; Nakagawa, Kiyomasa; Yamamoto, Etsuhide
2009-04-01
To examine the separation of the pterygomaxillary region at the posterior nasal spine level after Le Fort I osteotomy in Class III patients. The study group consisted of 37 Japanese patients with mandibular prognathism and asymmetry, with maxillary retrognathism or asymmetry. A total of 74 sides were examined. Le Fort I osteotomy was performed without a pterygoid osteotome, with an ultrasonic curette used to remove interference at the pterygomaxillary region. Postoperative computed tomography (CT) was analyzed for all patients. The separation of the pterygomaxillary region and the location of the descending palatine artery were assessed. Although acceptable separation between the maxilla and pterygoid plates was achieved in all patients, an exact separation of the pterygomaxillary junction at the posterior nasal spine level was found in only 18 of 74 sides (24%). In 29 of 74 sides (39.2%), the separation occurred anterior to the descending palatine artery. In 29 of 74 sides (39.2%), complete separation between the maxilla and lateral and/or medial pterygoid plate was not achieved, but lower level separation of the maxilla and pterygoid plate was always complete. The maxillary segments could be moved to the postoperative ideal position in all cases. Le Fort I osteotomy without an osteotome does not always induce an exact separation at the pterygomaxillary junction at the posterior nasal spine level, but the ultrasonic bone curette can remove the interference between maxillary segment and pterygoid plates more safely.
Energy Technology Data Exchange (ETDEWEB)
Brown, C.A.; Mahuran, D.J. (Univ. of Toronto (Canada))
1993-08-01
In vitro mutagenesis and transient expression in COS cells has been used to associate a missense mutation with a clinical or biochemical phenotype. Mutations affecting the [alpha]-subunit of [beta]-hexosaminidase A ([alpha][beta]) (E.C.3.2.1.52) result in Tay-Sachs disease. Because hexosaminidase A is heterodimeric, analysis of [alpha]-chain mutations is not straightforward. The authors examine three approaches utilizing previously identified mutations affecting [alpha]-chain folding. These involve transfection of (1) the [alpha] cDNA alone; (2) a [beta] cDNA construct encoding a [beta]-subunit substituted at a position homologous to that of the [alpha]-subunit, and (3) both [alpha] and [beta] cDNAs. The latter two procedures amplified residual activity levels over that of patient samples, an effect not previously found with mutations affecting an [open quotes]active[close quotes] [alpha]Arg residue. This effect may help to discriminate between protein-folding and active-site mutations. The authors conclude that, with proper controls, the latter method of cotransfection can be used to evaluate the effects and perhaps to predict the clinical course of some [alpha]-chain mutations. Using this technique, they demonstrate that the adult-onset Tay-Sachs mutation, [alpha]Gly[yields]Ser[sup 269], does not directly affect [alpha][beta] dimerization but exerts an indirect effect on the dimer through destabilizing the folded [alpha]-subunit at physiological temperatures. Two other [alpha] mutations linked to more severe phenotypes appear to inhibit the initial folding of the subunit. 36 refs., 2 figs., 5 tabs.
Energy Technology Data Exchange (ETDEWEB)
Sumner, Dennis [City of Fort Collins Utilities, CO (United States); Vosburg, Tom [City of Fort Collins Utilities, CO (United States); Brunner, Steve [Brendle Group, Fort Collins, CO (United States); Gates, Judy [Woodward, Inc., Fort Collins, CO (United States); Howard, Nathan [Spirae, Inc., Fort Collins, CO (United States); Merton, Andrew [Spirae, Inc., Fort Collins, CO (United States); Wright, Don [Spirae, Inc., Fort Collins, CO (United States); Birlingmair, Doug [Spirae, Inc., Fort Collins, CO (United States)
2015-10-01
This project titled “Research, Development and Demonstration of Peak Load Reduction on Distribution Feeders Using Distributed Energy Resources for the City of Fort Collins” evolved in response to the Department of Energy’s (DOE) Funding Opportunity Announcement (FOA) Number DE-PS26-07NT43119. Also referred to as the Fort Collins Renewable and Distributed System Integration (RDSI) Project, the effort was undertaken by a diverse group of local government, higher education and business organizations; and was driven by three overarching goals: I. Fulfill the requirements of the DOE FOA’s Area of Interest 2: Renewable and Distributed System Integration; most notably, to demonstrate the ability to reduce electric system distribution feeder peak load by 15% or more through the coordinated use of Distributed Energy Resources (DER). II. Advance the expertise, technologies and infrastructure necessary to support the long term vision of the Fort Collins Zero Energy District (FortZED) and move towards creating a zero energy district in the Fort Collins “Old Town” area. III. Further the goals of the City of Fort Collins Energy Policy, including the development of a Smart Grid-enabled distribution system in Fort Collins, expanded use of renewable energy, increased energy conservation, and peak load reduction. Through the collaborative efforts of the partner organizations, the Fort Collins RDSI project was successful in achieving all three of these goals. This report is organized into two distinct sections corresponding to the two phases of the project: • Part 1: Feeder Peak Load Reduction and the FortZED Initiative. • Part 2: Forming and Operating Utility Microgrids and Managing Load and Production Variability The original project scope addressed the Part 1 feeder peak load reduction. That work took place from 2009 through 2011 and was largely complete when the project scope was amended to include a demonstration of microgrid operations. While leveraging the
A non-conventional procedure for the 3D modeling of WWI forts
Nocerino, E.; Fiorillo, F.; Minto, S.; Menna, F.; Remondino, F.
2014-06-01
2014 is the hundredth anniversary of the outbreak of the First World War (WWI) - or Great War - in Europe and a number of initiatives have been planned to commemorate the tragic event. Until 1918, the Italian Trentino - Alto Adige region was under the Austro - Hungarian Empire and represented one of the most crucial and bloody war front between the Austrian and Italian territories. The region borders were constellated of military fortresses, theatre of battles between the two opposite troops. Unfortunately, most of these military buildings are now ruined and their architectures can be hardly appreciated. The paper presents the initial results of the VAST project (VAlorizzazione Storia e Territorio - Valorization of History and Landscape), that aims to digitally reconstruct the forts located on the plateaus of Luserna, Lavarone and Folgaria. An integrated methodology has been adopted to collect and employ all possible source of information in order to derive precise and photo-realistic 3D digital representations of WWI forts.
Georges Bataille and the Transgression of Taboos by Stephan Dedalus
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Shataw Naseri
2014-07-01
Full Text Available James Joyce's A Portrait of the Artist as a Young Man is not a pornographic novel like Georges Bataille' Story of the Eye; however, the present study attempts to trace Bataille's heterological notions in A Portrait. This paper attempts to see whether or not Stephan Dedalus as the main character of Joyce's literary work, has the potential to carry Batatille's heterogeneous elements which shatter any religious, linguistic, economic and political system. In order to reach this goal, the paper first attempts to establish the powerful dominance of the Catholic discourse, one of the strictest religious systems in the world, over Ireland which is the main setting of A Portrait. In the next part it will trace the authoritarian shadow of Catholicism and its impression upon Stephen Dedalus. Here, the principal aim is to indicate the significance of Stephen's transgressive acts in the novel and to see whether these transgressions have Bataillean nature as they shatter a very strict religious structure. Afterward, Stephen's transgressions as well as the implicit reaction of the religious system toward these transgressions will be investigated regarding Georges Bataille's heterogeneous notions.
76 FR 80744 - DoD Mandatory Declassification Review (MDR) Program
2011-12-27
... Component shall consult with DOS as necessary to determine whether the information is subject to a treaty or... the Chairman of the Joint Chiefs of Staff and the Joint Staff, the Combatant Commands, the Office of... Road, Suite 6884, Fort George G. Meade, MD 20755-6884. (17) North American Aerospace Defense Command...
From Myth to Reality: Humanities Study at Prince George's Community College.
Engleberg, Isa N.
In 1989, Prince George's Community College (PGCC) received a grant from the National Endowment for the Humanities to support a 4-week summer seminar in Greek mythology for humanities faculty. The seminar, entitled "The Nature and Function of Greek Mythology," provided enough financial compensation to free the faculty from summer school teaching,…
Planck 2015 results: XXI. The integrated Sachs-Wolfe effect
International Nuclear Information System (INIS)
Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.
2016-01-01
Here, this paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives. The CMB is cross-correlated with different large-scale structure (LSS) tracers: radio sources from the NVSS catalogue; galaxies from the optical SDSS and the infrared WISE surveys; and the Planck 2015 convergence lensing map. The joint cross-correlation of the CMB with the tracers yields a detection at 4σ where most of the signal-to-noise is due to the Planck lensing and the NVSS radio catalogue. In fact, the ISW effect is detected from the Planck data only at ≈3σ (through the ISW-lensing bispectrum), which is similar to the detection level achieved by combining the cross-correlation signal coming from all the galaxy catalogues mentioned above. We study the ability of the ISW effect to place constraints on the dark-energy parameters; in particular, we show that Ω Λ is detected at more than 3σ. This cross-correlation analysis is performed only with the Planck temperature data, since the polarization scales available in the 2015 release do not permit significant improvement of the CMB-LSS cross-correlation detectability. Nevertheless, the Planck polarization data are used to study the anomalously large ISW signal previously reported through the aperture photometry on stacked CMB features at the locations of known superclusters and supervoids, which is in conflict with ΛCDM expectations. We find that the current Planck polarization data do not exclude that this signal could be caused by the ISW effect. In addition, the stacking of the Planck lensing map on the locations of superstructures exhibits a positive cross-correlation with these large-scale structures. Finally, we have improved our previous reconstruction of the ISW temperature fluctuations by combining
Aerosols in King George Island (Antarctic peninsula) using PIXE and alpha spectrometry
International Nuclear Information System (INIS)
Dias da Cunha, K.; Medeiros, G.; Leal, M.A.; Lima, C.; Dalia, K.C.
2009-01-01
The aim of this study was to characterize the airborne particles and particles deposited in the recent snow samples collected at King George Island (Admiralty Bay) in order to evaluate the possible local sources of airborne particles and the aerosol transport from South America to Antarctic at sea level. Airborne particles samples were collected using a cascade impactor and cyclones at several sampling points at Admiralty Bay. Airborne particles were also collected during the ship travel from Rio de Janeiro to Antarctica. The recent snow samples and aerosols collected at several sampling points at Admiralty Bay were analyzed by PIXE for the determination of the elemental mass concentration. Snow samples were analyzed by alpha spectrometry to determine the 232Th, 228Th, 238U and 234U concentrations in snow. The Mass Median Aerodynamic Diameter of airborne particles was determined. The results suggest that there is a correlation between the aerosol samples and the particles deposited in the snow, but the elemental mass distributions are not equal. The snow elemental concentration can be used as an indicator of the elements present in the aerosols. The local aerosol sources (natural and anthropogenic) have been considered to characterize the aerosol transport to Antarctic, mainly King George Island. The main aerosol sources are the marine spray, weathering of local rocks and anthropogenic sources, as the diesel burning in the island. Besides the local aerosol sources the transport of airborne particles from south Atlantic to Antarctic is an important source of airborne particles at King George Island. (author)
Raamidest välja mõtlemine pole piisav / Gabor George Burt ; interv. Harli Uljas
Burt, Gabor George
2006-01-01
Juhtimisstrateegia Blue Ocean Strategy eestkõneleja Gabor George Burti sõnul tuleb edu saavutamiseks keskenduda kliendile ning tegeleda personaalselt kliendi jaoks sobiva lahenduse loomisega. Kommenteerib Priit Põldoja
Die opleiding van bedryfsielkundiges aan die universiteit van Fort Hare
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W. Botha
1977-11-01
Full Text Available Die Departement Bedryfsielkunde aan die Universiteit van Fort Hare is 'n relatiewe jong departement en het eers in 1965 tot stand gekom. Voor hierdie datum is Bedryfsielkunde as 'n kort kursus deur die departement van suiwer Sielkunde aangebied en een van die destydse dosente, Dr. W. Backer, het die inisiatief geneem om 'n selfstandige departement van Bedryfsielkunde in die Fakulteit van Ekonomiese Wetenskappe op die been te bring.
2002-01-01
Estonia kontserdisaalis esineb ERSO ees tippviiuldaja Lara St. John. Holland Music Sessions'i meistrikursustele pääses konkursi korras kuus eesti noort muusikut. Vene Draamateatris 17. III toimuvast kontserdist "Georg Otsa jälgedes"
George Orwell and 1984: a personal view
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ALFREDO SANDOVAL GÓMEZ
2013-11-01
Full Text Available George Orwell´s 1984 is considered a great negative utopia, in the sense it depicts the nightmare of what life might become in an oligarchic collectivism pursued to its logical conclusion. Under a social setup which is nothing but totalitarian barbarism, eternal warfare is the price one pays for an elusive peace. The Party with capital P keeps a total control over all of man´s actions as well as thoughts . The novel is a great satire and it attempts to diagnose man´s alienation in all its aspects, but with special emphasis on the social organization recommended by Marx and practiced by Stalin.
[Georg Friedrich Nicolai: war physician against war].
van Bergen, L
2017-01-01
Georg Friedrich Nicolai was a German professor and heart specialist who was one of the few who protested against the war at the beginning of World War I. As a result, he lost his job and was convicted. After the war, right-wing nationalist students and lack of support from his university superiors made it impossible for him to teach. He left Germany in 1922, never to return. In his book, Die Biologie des Krieges (The Biology of War), which was published in neutral Switzerland in 1917, he contradicted the social Darwinist idea - supported by many physicians as well - that war strengthened humanity, people and races, physically and mentally. On the contrary, he argued, war is biologically counterproductive.
Directory of Open Access Journals (Sweden)
Paolo Di Pietro Martinelli
2016-12-01
Full Text Available Fort360 project is a cultural initiative that receives the main directives of edutainment processes, trying to provide an answer to the necessity of a capillary system of information and awareness about the dismissing cultural heritage. The proposed study – carried out in the Fort Bravetta, Rome – presents a video where the educational aspect, related to the historical and architectural site contents, is strictly connected with the playful and emotional quality, resulted from a VR interaction with a panoramic video. This first case study focuses on the use of low-cost digital instrumentation and tries to improve the value of culture from the bottom, proposing an alternative way of cultural heritage enjoyment, based on participation and on interdisciplinarity of the proposed contents.
76 FR 71611 - Notice of Establishment of the Fort Winfield Scott Advisory Committee
2011-11-18
... (``Committee''). The Committee will advise the Executive Director of the Presidio Trust on matters pertaining... of once every three months. Nominations: The Presidio Trust will consider nominations of all... PRESIDIO TRUST Notice of Establishment of the Fort Winfield Scott Advisory Committee AGENCY: The...
An ecological response model for the Cache la Poudre River through Fort Collins
Shanahan, Jennifer; Baker, Daniel; Bledsoe, Brian P.; Poff, LeRoy; Merritt, David M.; Bestgen, Kevin R.; Auble, Gregor T.; Kondratieff, Boris C.; Stokes, John; Lorie, Mark; Sanderson, John
2014-01-01
The Poudre River Ecological Response Model (ERM) is a collaborative effort initiated by the City of Fort Collins and a team of nine river scientists to provide the City with a tool to improve its understanding of the past, present, and likely future conditions of the Cache la Poudre River ecosystem. The overall ecosystem condition is described through the measurement of key ecological indicators such as shape and character of the stream channel and banks, streamside plant communities and floodplain wetlands, aquatic vegetation and insects, and fishes, both coolwater trout and warmwater native species. The 13- mile-long study area of the Poudre River flows through Fort Collins, Colorado, and is located in an ecological transition zone between the upstream, cold-water, steep-gradient system in the Front Range of the Southern Rocky Mountains and the downstream, warm-water, low-gradient reach in the Colorado high plains.
Directory of Open Access Journals (Sweden)
S. R. Verkulich
2013-01-01
Full Text Available The interstadial marine deposits stratum was described in the Fildes Peninsula (King George Island due to field and laboratory investigations during 2008–2011. The stratum fragments occur in the west and north-west parts of peninsula in following forms: sections of soft sediments, containing fossil shells, marine algae, bones of marine animals and rich marine diatom complexes in situ (11 sites; fragments of shells and bones on the surface (25 sites. According to the results of radiocarbon dating, these deposits were accumulated within the period 19–50 ky BP. Geographical and altitude settings of the sites, age characteristics, taxonomy of fossil flora and fauna, and good safety of the soft deposits stratum allow to make following conclusions: during interstadial, sea water covered significant part of King George Island up to the present altitude of 40 m a.s.l., and the King George Island glaciation had smaller size then; environmental conditions for the interstadial deposit stratum accumulation were at least not colder than today; probably, the King George island territory was covered entirely by ice masses of Last glacial maximum not earlier than 19 ky BP; during Last glacial maximum, King George Island was covered by thin, «cold», not mobile glaciers, which contribute to conservation of the soft marine interstadial deposits filled with fossil flora and fauna.
Fagernes, Therese
2011-01-01
The presidency of George W. Bush was a period of controversy. The foreign policy that the administration implemented would be criticized both inside of the United States and across the world. The purpose of this thesis is to look at how the senior members of the Bush administration’s foreign policy team influenced the foreign policy process during President George Walker Bush’s first term. It will apply the interaction and bitter opposition between these individuals and the defining events th...
Embedded Lensing Time Delays, the Fermat Potential, and the Integrated Sachs-Wolfe Effect
Chen, Bin; Kantowski, Ronald; Dai, Xinyu
2015-05-01
We derive the Fermat potential for a spherically symmetric lens embedded in a Friedman-Lemaître-Robertson-Walker cosmology and use it to investigate the late-time integrated Sachs-Wolfe (ISW) effect, i.e., secondary temperature fluctuations in the cosmic microwave background (CMB) caused by individual large-scale clusters and voids. We present a simple analytical expression for the temperature fluctuation in the CMB across such a lens as a derivative of the lens’ Fermat potential. This formalism is applicable to both linear and nonlinear density evolution scenarios, to arbitrarily large density contrasts, and to all open and closed background cosmologies. It is much simpler to use and makes the same predictions as conventional approaches. In this approach the total temperature fluctuation can be split into a time-delay part and an evolutionary part. Both parts must be included for cosmic structures that evolve and both can be equally important. We present very simple ISW models for cosmic voids and galaxy clusters to illustrate the ease of use of our formalism. We use the Fermat potentials of simple cosmic void models to compare predicted ISW effects with those recently extracted from WMAP and Planck data by stacking large cosmic voids using the aperture photometry method. If voids in the local universe with large density contrasts are no longer evolving we find that the time delay contribution alone predicts values consistent with the measurements. However, we find that for voids still evolving linearly, the evolutionary contribution cancels a significant part of the time delay contribution and results in predicted signals that are much smaller than recently observed.
George Jeffreys: Pentecostal and Contemporary Implications
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William K Kay
2018-02-01
Full Text Available The life and work of the Welsh evangelist George Jeffreys resulted in the planting of two denominations in the UK between 1915 and 1962, when he died. The Elim churches continue to this day to be one of the larger classical Pentecostal denominations in the UK, while the Bible Pattern Fellowship dispersed on Jeffreys’ death. The disputes that led to Jeffreys’ departure from Elim were said to have arisen from his adherence to British Israel doctrine, though his supporters believed they arose from his championing of local church ownership and democracy. This paper considers sociological and other reasons for Jeffreys’ remarkable success in the interwar years and his eventual departure from a denomination he founded. It concludes by reflecting on topics (such as the importance of debate and law that have relevance for contemporary Pentecostalism.
International Nuclear Information System (INIS)
Faisal, K.; Gamal El-Din, M.
2006-01-01
Ambient air trends were assessed using data collected over an 8 year period from monitoring stations in Edmonton and Fort McKay, Alberta. In particular, the study evaluated the short term trends in the concentration of carbon monoxide (CO), nitrogen dioxide (NO 2 ), ozone (O 3 ), and particulate matter (PM 2.5 ) in Edmonton, as well as the NO 2 , O 3 , PM 2.5 , and total hydrocarbons in Fort McKay. In order to evaluate the ambient air trends, this study examined the changes in concentrations of these pollutants between the 50 - 90 percentiles of concentration distributions for a calendar year. These statistics were assumed to be linear over the period of study and fitted using simple linear regression. Hypothesis tests were performed to determine if the slopes of the best-fit lines were greater or less than zero. There was no indication of a statistically significant short-term trend for NO 2 and O 3 for the city of Edmonton. However, statistically pronounced decreasing trends were noted for CO and PM 2.5 . There was no indication of statistically significant trend for any of the pollutants examined at Fort McKay over the study period. It was cautioned that since the period of study over which trends were examined was short, the changes or lack of changes observed do not necessarily indicate long term trends. However, the results suggest that air quality has remained unchanged during the last 6 to 8 years, despite increased economic development in Edmonton and continued oil sands development in Fort McKay
Reseña de HYPER-TEXT-THEORY, ed. George Landow.
García Landa, José Ángel
2010-01-01
Reseña del libro editado por George P. Landow HYPER/TEXT/THEORY (Baltimore: Johns Hopkins UP, 1994), volumen sobre el impacto del hipertexto en teoría literaria, narratología y escritura experimental. La reseña atiende sobre todo a los desarrollos complementarios a la teoría de Landow que podían vislumbrarse en los primeros años del hipertexto global, la World Wide Web.
Cultural keystone species in oil sands mine reclamation, Fort McKay, Alberta, Canada
Energy Technology Data Exchange (ETDEWEB)
Garibaldi, A.; Straker, J. [Stantec Ltd., Sidney, BC (Canada)
2009-07-01
Cultural keystone species (CKS) shape the cultural identify of people through the roles they have in diet, material and spiritual practices. The use of the CKS concept is regarded as a method of addressing linked social and ecological issues. This paper presented the results of using the CKS model in the indigenous community of Fort McKay, Alberta to address, social, ecological and spiritual values in regional mine-land reclamation. Fort McKay is at the epicenter of the existing mine developments. Its residents regard human and environmental health to be be linked and therefore experience the effects of development and subsequent reclamation on both cultural and ecological levels. The community is actively engaged in working with the local mining companies on issues of mine reclamation design. In order to hold meaning to the local people, oil sand operators used the CKS concept in their reclamation efforts to take into account ecological functionality and also address the linked social factors. Five CKS were identified through a literature review and extensive community interviews. The list includes moose, cranberry, blueberry, ratroot and beaver. These 5 CKS were used to focus discussions and make recommendations for relevant land reclamation within Fort McKay traditional territory. The project has influenced the way both the community and oil sands operators engage with reclamation. Lessons learned from this process will help direct reclamation activities on other portions of traditional territory, while offering guidance to other regional developers for addressing cultural values in reclamation on their leases. 15 refs., 1 fig.
Drilling and Testing the DOI041A Coalbed Methane Well, Fort Yukon, Alaska
Clark, Arthur; Barker, Charles E.; Weeks, Edwin P.
2009-01-01
The need for affordable energy sources is acute in rural communities of Alaska where costly diesel fuel must be delivered by barge or plane for power generation. Additionally, the transport, transfer, and storage of fuel pose great difficulty in these regions. Although small-scale energy development in remote Arctic locations presents unique challenges, identifying and developing economic, local sources of energy remains a high priority for state and local government. Many areas in rural Alaska contain widespread coal resources that may contain significant amounts of coalbed methane (CBM) that, when extracted, could be used for power generation. However, in many of these areas, little is known concerning the properties that control CBM occurrence and production, including coal bed geometry, coalbed gas content and saturation, reservoir permeability and pressure, and water chemistry. Therefore, drilling and testing to collect these data are required to accurately assess the viability of CBM as a potential energy source in most locations. In 2004, the U.S. Geological Survey (USGS) and Bureau of Land Management (BLM), in cooperation with the U.S. Department of Energy (DOE), the Alaska Department of Geological and Geophysical Surveys (DGGS), the University of Alaska Fairbanks (UAF), the Doyon Native Corporation, and the village of Fort Yukon, organized and funded the drilling of a well at Fort Yukon, Alaska to test coal beds for CBM developmental potential. Fort Yukon is a town of about 600 people and is composed mostly of Gwich'in Athabascan Native Americans. It is located near the center of the Yukon Flats Basin, approximately 145 mi northeast of Fairbanks.
78 FR 60929 - Notice of Public Meeting of the Fort Scott Council
2013-10-02
.... Such requests must be stated prominently at the beginning of the comments. The Trust will make... PRESIDIO TRUST Notice of Public Meeting of the Fort Scott Council AGENCY: The Presidio Trust... Scott Council (Council) will be held from 10 a.m. to 12:30 p.m. on Thursday, October 17, 2013. The...
The Fort Logan Lodge: Intentional Community for Chronic Mental Patients. Final Report.
Fort Logan Mental Health Center, Denver, CO.
This report attempts to identify important variables affecting the success of the Lodge Program, affiliated with the Fort Logan Mental Health Center. The Lodge Program is a community based, group oriented, social and work program for the rehabilitation of the refractory, long stay mental patient. Findings reported include the following: (1) the…
Possible Location of Gaspar Dias Fort in Relation to the Present River Bank
Digital Repository Service at National Institute of Oceanography (India)
Mascarenhas, A.; Tripati, S.; ManiMurali, R.
, it would be worthwhile to delineate the past river bank with respect to the present one, and to check whether any morphological changes occurred since then. Although the fort is marked by the river side in historical maps, the exact position of the shore...
The extent and causes of stress in teachers in the George region
African Journals Online (AJOL)
Erna Kinsey
The purpose of this particular research project was to establish which aspects of the teaching profession are stress-related in the. George area. ... for teachers to manage their stress are based on these conclusions. ... Positive (good) stress (for example an opportunity, a promotion, .... school classroom (Hanks, 1990:1213).